Science.gov

Sample records for societal alignment strategy

  1. “Working to shape what society's expectations of us should be”: Philip Morris' societal alignment strategy

    PubMed Central

    Yang, J S; Malone, R E

    2009-01-01

    Background A key element of Philip Morris's (PM's) corporate social responsibility initiatives is “societal alignment”, defined as “strategies and programs to meet society's expectations of a responsible tobacco company”. This study explored the genesis and implementation of Philip Morris' (PM) societal alignment efforts. Methods The study retrieved and analysed approximately 375 previously undisclosed PM documents now available electronically. Using an iterative process, the study categorised themes and prepared a case analysis. Results Beginning in 1999, PM sought to become “societally aligned” by identifying expectations of a responsible tobacco company through public opinion research and developing and publicising programs to meet those expectations. Societal alignment was undertaken within the US and globally to ensure an environment favourable to PM's business objectives. Despite PM's claims to be “changing”, however, societal alignment in practice was highly selective. PM responded to public “expectations” largely by retooling existing positions and programs, while entirely ignoring other expectations that might have interfered with its business goals. It also appears that convincing employees of the value and authenticity of societal alignment was difficult. Conclusions As implementation of the Framework Convention on Tobacco Control proceeds, tobacco control advocates should closely monitor development of such “alignment” initiatives and expose the motivations and contradictions they reveal. PMID:18845623

  2. Aligning for Innovation - Alignment Strategy to Drive Innovation

    NASA Technical Reports Server (NTRS)

    Johnson, Hurel; Teltschik, David; Bussey, Horace, Jr.; Moy, James

    2010-01-01

    With the sudden need for innovation that will help the country achieve its long-term space exploration objectives, the question of whether NASA is aligned effectively to drive the innovation that it so desperately needs to take space exploration to the next level should be entertained. Authors such as Robert Kaplan and David North have noted that companies that use a formal system for implementing strategy consistently outperform their peers. They have outlined a six-stage management systems model for implementing strategy, which includes the aligning of the organization towards its objectives. This involves the alignment of the organization from the top down. This presentation will explore the impacts of existing U.S. industrial policy on technological innovation; assess the current NASA organizational alignment and its impacts on driving technological innovation; and finally suggest an alternative approach that may drive the innovation needed to take the world to the next level of space exploration, with NASA truly leading the way.

  3. Strategies for active alignment of lenses

    NASA Astrophysics Data System (ADS)

    Langehanenberg, Patrik; Heinisch, Josef; Wilde, Chrisitan; Hahne, Felix; Lüerß, Bernd

    2015-10-01

    Today's optical systems require up-to-date assembly and joining technology. The trend of keeping dimensions as small as possible while maintaining or increasing optical imaging performance leaves little to no room for mechanical lens adjustment equipment that may remain in the final product. In this context active alignment of optical elements opens up possibilities for the fast and cost-economic manufacturing of lenses and lens assemblies with highest optical performance. Active alignment for lens manufacturing is the precise alignment of the optical axis of a lens with respect to an optical or mechanical reference axis (e.g. housing) including subsequent fixation by glue. In this contribution we will describe different approaches for active alignment and outline strengths and limitations of the different methods. Using the SmartAlign principle, highest quality cemented lenses can be manufactured without the need for high precision prealignment, while the reduction to a single alignment step greatly reduces the cycle time. The same strategies can also be applied to bonding processes. Lenses and lens groups can be aligned to both mechanical and optical axes to maximize the optical performance of a given assembly. In hybrid assemblies using both mechanical tolerances and active alignment, SmartAlign can be used to align critical lens elements anywhere inside the system for optimized total performance. Since all geometrical parameters are re-measured before each alignment, this process is especially suited for complex and time-consuming production processes where the stability of the reference axis would otherwise be critical. For highest performance, lenses can be actively aligned using up to five degrees of freedom. In this way, SmartAlign enables the production of ultra-precise mounted lenses with an alignment precision below 1 ?m.

  4. A Method for Recommending Ontology Alignment Strategies

    NASA Astrophysics Data System (ADS)

    Tan, He; Lambrix, Patrick

    In different areas ontologies have been developed and many of these ontologies contain overlapping information. Often we would therefore want to be able to use multiple ontologies. To obtain good results, we need to find the relationships between terms in the different ontologies, i.e. we need to align them. Currently, there already exist a number of different alignment strategies. However, it is usually difficult for a user that needs to align two ontologies to decide which of the different available strategies are the most suitable. In this paper we propose a method that provides recommendations on alignment strategies for a given alignment problem. The method is based on the evaluation of the different available alignment strategies on several small selected pieces from the ontologies, and uses the evaluation results to provide recommendations. In the paper we give the basic steps of the method, and then illustrate and discuss the method in the setting of an alignment problem with two well-known biomedical ontologies. We also experiment with different implementations of the steps in the method.

  5. Alignment strategy for the ATLAS tracker

    SciTech Connect

    ATLAS; Golling, T.

    2007-09-23

    The ATLAS experiment is a multi-purpose particle detector that will study high-energy particle collisions produced by the Large Hadron Collider. For the reconstruction of charged particles, and their production and their decay vertices, ATLAS is equipped with a sophisticated tracking system, unprecedented in size and complexity. Full exploitation of both the Inner Detector and the muon spectrometer requires an accurate alignment. The challenge of aligning the ATLAS tracking devices is discussed, and the ATLAS alignment strategy is presented and illustrated with both data and Monte Carlo results.

  6. Strategies and tools for whole genome alignments

    SciTech Connect

    Couronne, Olivier; Poliakov, Alexander; Bray, Nicolas; Ishkhanov,Tigran; Ryaboy, Dmitriy; Rubin, Edward; Pachter, Lior; Dubchak, Inna

    2002-11-25

    The availability of the assembled mouse genome makespossible, for the first time, an alignment and comparison of two largevertebrate genomes. We have investigated different strategies ofalignment for the subsequent analysis of conservation of genomes that areeffective for different quality assemblies. These strategies were appliedto the comparison of the working draft of the human genome with the MouseGenome Sequencing Consortium assembly, as well as other intermediatemouse assemblies. Our methods are fast and the resulting alignmentsexhibit a high degree of sensitivity, covering more than 90 percent ofknown coding exons in the human genome. We have obtained such coveragewhile preserving specificity. With a view towards the end user, we havedeveloped a suite of tools and websites for automatically aligning, andsubsequently browsing and working with whole genome comparisons. Wedescribe the use of these tools to identify conserved non-coding regionsbetween the human and mouse genomes, some of which have not beenidentified by other methods.

  7. Aligning IT and Business Strategy: An Australian University Case Study

    ERIC Educational Resources Information Center

    Dent, Alan

    2015-01-01

    Alignment with business objectives is considered to be an essential outcome of information technology (IT) strategic planning. This case study examines the process of creating an IT strategy for an Australian university using an industry standard methodology. The degree of alignment is determined by comparing the strategic priorities supported by…

  8. Aligning IT and Business Strategy: An Australian University Case Study

    ERIC Educational Resources Information Center

    Dent, Alan

    2015-01-01

    Alignment with business objectives is considered to be an essential outcome of information technology (IT) strategic planning. This case study examines the process of creating an IT strategy for an Australian university using an industry standard methodology. The degree of alignment is determined by comparing the strategic priorities supported by…

  9. Chemical strategies for die/wafer submicron alignment and bonding.

    SciTech Connect

    Martin, James Ellis; Baca, Alicia I.; Chu, Dahwey; Rohwer, Lauren Elizabeth Shea

    2010-09-01

    This late-start LDRD explores chemical strategies that will enable sub-micron alignment accuracy of dies and wafers by exploiting the interfacial energies of chemical ligands. We have micropatterned commensurate features, such as 2-d arrays of micron-sized gold lines on the die to be bonded. Each gold line is functionalized with alkanethiol ligands before the die are brought into contact. The ligand interfacial energy is minimized when the lines on the die are brought into registration, due to favorable interactions between the complementary ligand tails. After registration is achieved, standard bonding techniques are used to create precision permanent bonds. We have computed the alignment forces and torque between two surfaces patterned with arrays of lines or square pads to illustrate how best to maximize the tendency to align. We also discuss complex, aperiodic patterns such as rectilinear pad assemblies, concentric circles, and spirals that point the way towards extremely precise alignment.

  10. An alignment strategy for the optics of LINC-NIRVANA

    NASA Astrophysics Data System (ADS)

    Meschke, Daniel; Bertram, Thomas; Bizenberger, Peter

    2012-09-01

    LINC-NIRVANA is an instrument to combine the light from both LBT primary mirrors in an imaging Fizeau interferometer. The goals in terms of resolution and field of view are quite ambitious, which leads to a complex instrument consisting of a bunch of subsystems. The layer oriented MCAO system alone is already quite complicated and to get everything working together properly is not a small challenge. As we are reaching the completion of LINC-NIRVANA's subsystems, it becomes more and more important to define a strategy to align all these various subsystems. The specific layout of LINC-NIRVANA imposes some restrictions and difficulties on the sequence and the method of this alignment. The main problem for example is that we have to get two perfectly symmetrical focal planes to be able to properly combine them interferometrically. This is the major step on which all further alignment is based on, since all the subsystems (collimator and camera optics, wavefront sensors, cold IR optics, etc.) rely on these focal planes as a reference. I will give a small introduction on the optics of the instrument and line out the resulting difficulties as well as the strategy that we want to apply in order to overcome these.

  11. Business Alignment: Measurement-Based Alignment of Software Strategies and Business Goals

    NASA Astrophysics Data System (ADS)

    Münch, Jürgen; Heidrich, Jens; Mandi?, Vladimir

    Most of today’s products and services are software-based. Organizations that develop software want to maintain and improve their competitiveness by controlling software-related risks. To do this, they need to align their business goals with software development strategies and translate them into quantitative project management. There is also an increasing need to justify cost and resources for software and system development and other IT services by demonstrating their impact on an organization’s higher-level goals. For both, linking business goals and software-related efforts in an organization is necessary. However, this is a challenging task, and there is a lack of methods addressing this gap.

  12. Buckling of aligned carbon nanotubes as stretchable conductors: a new manufacturing strategy.

    PubMed

    Zhu, Yong; Xu, Feng

    2012-02-21

    A new manufacturing strategy for buckling of aligned carbon nanotubes is developed, which does not involve prestretching the substrate but relies on the interface interaction between the nanotubes and the substrate. More specifically, upon stretching the substrate the nanotubes slide on the substrate, but upon releasing the nanotubes buckle. Following this manufacturing strategy, stretchable conductors based on aligned carbon nanotubes are demonstrated. PMID:22271642

  13. Aligning Transition and Standards-Based Education: Issues and Strategies.

    ERIC Educational Resources Information Center

    Kochhar-Bryant, Carol, Ed.; Bassett, Diane S., Ed.

    Eleven papers address issues in the alignment of standards-based education and individualized transition planning and service development for students with disabilities including differences in assumptions and principles, the transition planning model as a framework for achieving this alignment, and educational practices resulting from this…

  14. An Analysis of Strategies for Teaching Standards-Based Lesson Plan Alignment to Preservice Teachers

    ERIC Educational Resources Information Center

    Drost, Bryan R.; Levine, Anita C.

    2015-01-01

    Research consistently shows that well-aligned lesson plans lead to better student learning outcomes. The development of these plans challenges both preservice teachers and the teacher educators who instruct them. This exploratory study examined strategies for teaching lesson plan alignment utilized by 87 teacher educators in the United States.…

  15. An Analysis of Strategies for Teaching Standards-Based Lesson Plan Alignment to Preservice Teachers

    ERIC Educational Resources Information Center

    Drost, Bryan R.; Levine, Anita C.

    2015-01-01

    Research consistently shows that well-aligned lesson plans lead to better student learning outcomes. The development of these plans challenges both preservice teachers and the teacher educators who instruct them. This exploratory study examined strategies for teaching lesson plan alignment utilized by 87 teacher educators in the United States.…

  16. Educational Leaders' Doctoral Research That Informed Strategies to Steer Their Organizations towards Cultural Alignment

    ERIC Educational Resources Information Center

    Taysum, Alison

    2016-01-01

    This research generates new knowledge about how 24 educational leaders in the USA and England used their doctoral research to build narrative capital to inform strategies to steer their organizations towards cultural alignment. Cultural alignment prevents forms of segregation rooted in nation-states' wider historiography of education segregation…

  17. Electron Beam Alignment Strategy in the LCLS Undulators

    SciTech Connect

    Nuhn, H.-D.; Emma, P.J.; Gassner, G.L.; LeCocq, C.M.; Peters, E.; Ruland, R.E.; /SLAC

    2007-01-03

    The x-ray FEL process puts very tight tolerances on the straightness of the electron beam trajectory (2 {micro}m rms) through the LCLS undulator system. Tight but less stringent tolerances of 80 {micro}m rms vertical and 140 {micro}m rms horizontally are to be met for the placement of the individual undulator segments with respect to the beam axis. The tolerances for electron beam straightness can only be met through beam-based alignment (BBA) based on electron energy variations. Conventional alignment will set the start conditions for BBA. Precision-fiducialization of components mounted on remotely adjustable girders and the use of beam-finder wires (BFW) will satisfy placement tolerances. Girder movement due to ground motion and temperature changes will be monitored continuously by an alignment monitoring system (ADS) and remotely corrected. This stabilization of components as well as the monitoring and correction of the electron beam trajectory based on BPMs and correctors will increase the time between BBA applications. Undulator segments will be periodically removed from the undulator Hall and measured to monitor radiation damage and other effects that might degrade undulator tuning.

  18. The Alignment of Global Management Strategies, International Communication Approaches, and Individual Rhetorical Choices.

    ERIC Educational Resources Information Center

    Leininger, Carol

    1997-01-01

    Suggests that thinking about international communication within a framework that aligns an organization's global management strategies with international communication practices enhances not only consulting practice but teaching as well. Describes the framework, and argues it introduces ways of thinking about global management strategies and their…

  19. Organizational performance, Marketing strategy, and Financial strategic alignment: an empirical study on Iranian pharmaceutical firms

    PubMed Central

    2013-01-01

    Background Strategic Functional-level planning should be aligned with business level and other functional strategies of a company. It is presumed that assimilating the strategies could have positive contribution to business performance, in this regard alignment between marketing strategy and financial strategy seems to be the most important strategies being studied. An empirical work in generic pharmaceutical manufacturing companies for evaluating effect of alignment between these two functions on organizational performance was developed in this paper. Methods All Iranian pharmaceutical generic manufactures listed in Tehran stock market have been tested for period of five years between 2006–2010 and their marketing strategies were determined by using Slater and Olson taxonomy and their financial strategies have been developed by calculating total risk and total return of sample companies for five years based on rate of risk and return in the frame of a 2 × 2 matrix. For the business performance three profitability indices including Q-Tubin (Rate of market value to net asset value), ROA (Return on Asset), ROE (Return on Equity) have been tested. For analysis, a series of one-way ANOVAs as a collection of statistical models within marketing strategies considering financial strategy as independent variable and the three performance measures as dependent variables was used. Results Results show strategic alignment between financial and marketing has significant impact on profitability of company resulting in arise of all three profitability indices. Q tubing’s rate were 2.33,2.09,2.29,2.58 and rate of ROA were 0.21,0.194,0.25,0.22 and rate of ROE were 0.44,0.46,0.45,0.42 for matched strategy types, respectively the rates shown here are more than average meaning that specific type of marketing strategy is fitted with specific type of financial strategy. Conclusion Managers should not consider decisions regarding marketing strategy independently of their financial strategy. PMID:23915467

  20. Decomposition strategies for self-aligned double patterning

    NASA Astrophysics Data System (ADS)

    Ma, Yuansheng; Sweis, Jason; Bencher, Chris; Dai, Huixiong; Chen, Yongmei; Cain, Jason P.; Deng, Yunfei; Kye, Jongwook; Levinson, Harry J.

    2010-03-01

    Spacer technology, a self-aligned double patterning (SADP) technique, has been drawing more and more attention due to its less stringent overlay requirements compared to other double-patterning methods. However, use of SADP techniques was previously limited by the lack of flexibility in terms of decomposition options , and significant developments were mainly implemented for 1D-type applications for memory. In this paper, we extend the SADP technique into the logic field. A matrix of design rule extraction structures was created by GLOBALFOUNDRIES, which was then decomposed into 2-mask SADP patterning solutions by Cadence Design Systems, and wafers were manufactured by Applied Materials. The wafers were processed in both positive and negative spacer tones, and then we evaluate the design capabilities of SADP for logic BEOL patterning on pitches from 56nm to 64nm. It shows that the SADP has big advantage over other pitch splitting techniques such as LELE in terms of design rules, overlay, and CD uniformity control. With SADP, the most challenging design rules for BEOL such as tip-to-tip and tip-to-line can be reduced 50% from 80 nm to 40 nm.

  1. Aligning USGS senior leadership structure with the USGS science strategy

    USGS Publications Warehouse

    U.S. Geological Survey

    2010-01-01

    The U.S. Geological Survey (USGS) is realigning its management and budget structure to further enhance the work of its science programs and their interdisciplinary focus areas related to the USGS Science Strategy as outlined in 'Facing Tomorrow's Challenges-U.S. Geological Survey Science in the Decade 2007-2017' (U.S. Geological Survey, 2007). In 2007, the USGS developed this science strategy outlining major natural-science issues facing the Nation and focusing on areas where natural science can make a substantial contribution to the well being of the Nation and the world. These areas include global climate change, water resources, natural hazards, energy and minerals, ecosystems, and data integration.

  2. Managing the Right Projects: Best Practices to Align Project and Corporate Strategies

    NASA Technical Reports Server (NTRS)

    Watkins, Bobby

    2012-01-01

    If there's a human endeavor that exemplifies teamwork, it is space exploration. And that teamwork absolutely cannot happen effectively if the boots on the ground the people doing the work - don't understand how their work aligns with the larger goal. This presentation will discuss some best management practices from NASA's Marshall Space Flight Center that have succeeded in helping employees become informed, engaged and committed to the space agency's important missions. Specific topics include: Alignment Criteria: Linking Projects To Corporate Strategy. Resource Management: Best Practices For Resource Management. Strategic Analysis: Supporting Decision Making In A Changing Environment. Communication Strategies: Best Practices To Communicate Change. Benefits Achieved And Lessons Learned.

  3. Alignment strategies for the entrainment of music and movement rhythms.

    PubMed

    Moens, Bart; Leman, Marc

    2015-03-01

    Theories of entrainment assume that spontaneous entrainment emerges from dynamic laws that operate via mediators on interactions, whereby entrainment is facilitated if certain conditions are fulfilled. In this study, we show that mediators can be built that affect the entrainment of human locomotion to music. More specifically, we built D-Jogger, a music player that functions as a mediator between music and locomotion rhythms. The D-Jogger makes it possible to manipulate the timing differences between salient moments of the rhythms (beats and footfalls) through the manipulation of the musical period and phase, which affect the condition in which entrainment functions. We conducted several experiments to explore different strategies for manipulating the entrainment of locomotion and music. The results of these experiments showed that spontaneous entrainment can be manipulated, thereby suggesting different strategies on how to embark. The findings furthermore suggest a distinction among different modalities of entrainment: finding the beat (the most difficult part of entrainment), keeping the beat (easier, as a temporal scheme has been established), and being in phase (no entrainment is needed because the music is always adapted to the human rhythm). This study points to a new avenue of research on entrainment and opens new perspectives for the neuroscience of music. PMID:25773621

  4. Embedding strategies for effective use of information from multiple sequence alignments.

    PubMed Central

    Henikoff, S.; Henikoff, J. G.

    1997-01-01

    We describe a new strategy for utilizing multiple sequence alignment information to detect distant relationships in searches of sequence databases. A single sequence representing a protein family is enriched by replacing conserved regions with position-specific scoring matrices (PSSMs) or consensus residues derived from multiple alignments of family members. In comprehensive tests of these and other family representations, PSSM-embedded queries produced the best results overall when used with a special version of the Smith-Waterman searching algorithm. Moreover, embedding consensus residues instead of PSSMs improved performance with readily available single sequence query searching programs, such as BLAST and FASTA. Embedding PSSMs or consensus residues into a representative sequence improves searching performance by extracting multiple alignment information from motif regions while retaining single sequence information where alignment is uncertain. PMID:9070452

  5. DNA Familial Binding Profiles Made Easy: Comparison of Various Motif Alignment and Clustering Strategies

    PubMed Central

    Mahony, Shaun; Auron, Philip E; Benos, Panayiotis V

    2007-01-01

    Transcription factor (TF) proteins recognize a small number of DNA sequences with high specificity and control the expression of neighbouring genes. The evolution of TF binding preference has been the subject of a number of recent studies, in which generalized binding profiles have been introduced and used to improve the prediction of new target sites. Generalized profiles are generated by aligning and merging the individual profiles of related TFs. However, the distance metrics and alignment algorithms used to compare the binding profiles have not yet been fully explored or optimized. As a result, binding profiles depend on TF structural information and sometimes may ignore important distinctions between subfamilies. Prediction of the identity or the structural class of a protein that binds to a given DNA pattern will enhance the analysis of microarray and ChIP–chip data where frequently multiple putative targets of usually unknown TFs are predicted. Various comparison metrics and alignment algorithms are evaluated (a total of 105 combinations). We find that local alignments are generally better than global alignments at detecting eukaryotic DNA motif similarities, especially when combined with the sum of squared distances or Pearson's correlation coefficient comparison metrics. In addition, multiple-alignment strategies for binding profiles and tree-building methods are tested for their efficiency in constructing generalized binding models. A new method for automatic determination of the optimal number of clusters is developed and applied in the construction of a new set of familial binding profiles which improves upon TF classification accuracy. A software tool, STAMP, is developed to host all tested methods and make them publicly available. This work provides a high quality reference set of familial binding profiles and the first comprehensive platform for analysis of DNA profiles. Detecting similarities between DNA motifs is a key step in the comparative study of transcriptional regulation, and the work presented here will form the basis for tool and method development for future transcriptional modeling studies. PMID:17397256

  6. Societal assessment overview

    NASA Technical Reports Server (NTRS)

    Bloomquist, C. E.

    1980-01-01

    The decision to proceed with SPS depends on a political determination that commitment of the economic, institutional, and social energies required for its implementation is a worthwhile investment. This determination is national (and international) in scope and is based on knowledge of the environmental and societal impacts of the SPS, its projected economics and technological risks, expressed through the influence of contending segments of society. To assist the decision makers, an assessment of societal issues associated with the SPS was undertaken as part of the Concept Development and Evaluation Program. Results of the assessment are reported. The primary societal assessment objectives are to determine if the societal ramifications of an SPS might significantly impede its development, and to establish an information base regarding these issues. Estimates regarding SPS impacts commensurate with its stage of development and the needs of the decision makers are provided.

  7. Octree-Based SIMD Strategy for Icp Registration and Alignment of 3d Point Clouds

    NASA Astrophysics Data System (ADS)

    Eggert, D.; Dalyot, S.

    2012-07-01

    Matching and fusion of 3D point clouds, such as close range laser scans, is important for creating an integrated 3D model data infrastructure. The Iterative Closest Point algorithm for alignment of point clouds is one of the most commonly used algorithms for matching of rigid bodies. Evidently, scans are acquired from different positions and might present different data characterization and accuracies, forcing complex data-handling issues. The growing demand for near real-time applications also introduces new computational requirements and constraints into such processes. This research proposes a methodology to solving the computational and processing complexities in the ICP algorithm by introducing specific performance enhancements to enable more efficient analysis and processing. An Octree data structure together with the caching of localized Delaunay triangulation-based surface meshes is implemented to increase computation efficiency and handling of data. Parallelization of the ICP process is carried out by using the Single Instruction, Multiple Data processing scheme - based on the Divide and Conquer multi-branched paradigm - enabling multiple processing elements to be performed on the same operation on multiple data independently and simultaneously. When compared to the traditional non-parallel list processing the Octree-based SIMD strategy showed a sharp increase in computation performance and efficiency, together with a reliable and accurate alignment of large 3D point clouds, contributing to a qualitative and efficient application.

  8. Does alignment of constructivist teaching, curriculum, and assessment strategies promote meaningful learning?

    NASA Astrophysics Data System (ADS)

    Jimarez, Teresa

    Despite our national efforts to attract more students to the science, technology, engineering, and mathematics (STEM) fields, the number of students continues to be small. Empirical studies have suggested that in order to actively engage students in the science learning processes, lessons need to be designed which consider student prior experiences and provide a sound curriculum, within an environment promoting social interaction---that is, allowing for sharing and negotiation of those ideas which promote reflective thinking. These premises require an embedded assessment system that continuously provides feedback to both student and teacher. This technique allows adaptation and modification of lessons to better facilitate conceptual understanding. This study focused on the use of constructivist strategies that, when aligned, promoted conceptual understanding while facilitating development of science process skills. Skill development leads to meaningful learning, known to promote a change of attitude toward science. A mixed research design embedded in a case study approach was used to understand the complexity of the variables examined in this study. Both quantitative and qualitative methods of data collection were used to strengthen the validity and interpretation of the findings. Students from one of three ninth-grade physical science classes were selected for this study. The students numbered 29, 13 boys and 16 girls; the majority of these students were of Hispanic background. The analysis of data suggested that the use of constructivist strategies promotes conceptual understanding of science concepts and development of science process skills and a change of attitude towards science. This study concluded that selecting teaching and multiple assessment strategies is vital to engage students in science careers. Due to the limited nature of this case study, the researcher recommends a replication or followup with a different teacher and school, including a control group and student interviews to add validity to student written pieces of work.

  9. Societal costs of insomnia.

    PubMed

    Léger, Damien; Bayon, Virginie

    2010-12-01

    Insomnia is the most common sleeping disorder and has been recognized as a major public health issue, associated with a high societal cost. The aim of this review is firstly to understand how the socio-demographic and career characteristics of insomniacs may influence the economical consequences of this disease. Secondly, it also tries to explain how patients seek help to cope with their insomnia. The review aims to carefully describe the possible links between insomnia and public health concerns as to point out what are the certitudes and the missing data on the consequences of insomnia on work, economics, accidents, costs and health related quality of life (HrQol). PMID:20359916

  10. Alignment Strategies in Verbal Accounts of Problematic Conduct: The Case of Abortion.

    ERIC Educational Resources Information Center

    Zimmerman, Mary

    This paper reports the results of a survey on the attitudes of women who had just had voluntary abortions. The paper focuses on the attempt on the part of the women to bring their abortion-seeking behaviors in line with opposing cultural standards. The existing literature suggests that alignment can be accomplished through reducing the negative…

  11. A Multi-Objective Method to Align Human Resource Allocation with University Strategy

    ERIC Educational Resources Information Center

    Bouillard, Philippe

    2016-01-01

    Universities are currently under considerable pressure to reach their stakeholders' expectations. Management tools that use strategic plans, key performance indicators and quality assurance methods are increasingly deployed. This paper aims to demonstrate how resource allocation can be aligned with institutional strategic plans with a very simple…

  12. A Multi-Objective Method to Align Human Resource Allocation with University Strategy

    ERIC Educational Resources Information Center

    Bouillard, Philippe

    2016-01-01

    Universities are currently under considerable pressure to reach their stakeholders' expectations. Management tools that use strategic plans, key performance indicators and quality assurance methods are increasingly deployed. This paper aims to demonstrate how resource allocation can be aligned with institutional strategic plans with a very simple…

  13. Vertebrate gene finding from multiple-species alignments using a two-level strategy

    PubMed Central

    Carter, David; Durbin, Richard

    2006-01-01

    Background One way in which the accuracy of gene structure prediction in vertebrate DNA sequences can be improved is by analyzing alignments with multiple related species, since functional regions of genes tend to be more conserved. Results We describe DOGFISH, a vertebrate gene finder consisting of a cleanly separated site classifier and structure predictor. The classifier scores potential splice sites and other features, using sequence alignments between multiple vertebrate species, while the structure predictor hypothesizes coding transcripts by combining these scores using a simple model of gene structure. This also identifies and assigns confidence scores to possible additional exons. Performance is assessed on the ENCODE regions. We predict transcripts and exons across the whole human genome, and identify over 10,000 high confidence new coding exons not in the Ensembl gene set. Conclusion We present a practical multiple species gene prediction method. Accuracy improves as additional species, up to at least eight, are introduced. The novel predictions of the whole-genome scan should support efficient experimental verification. PMID:16925840

  14. Strategy Precedes Operational Effectiveness: Aligning High Graduation Rankings with Competitive Graduation Grade Point Averages

    ERIC Educational Resources Information Center

    Apprey, Maurice; Bassett, Kimberley C.; Preston-Grimes, Patrice; Lewis, Dion W.; Wood, Beverly

    2014-01-01

    Two pivotal and interconnected claims are addressed in this article. First, strategy precedes program effectiveness. Second, graduation rates and rankings are insufficient in any account of academic progress for African American students. In this article, graduation is regarded as the floor and not the ceiling, as it were. The ideal situation in…

  15. A Therapeutic Strategy for Spinal Cord Defect: Human Dental Follicle Cells Combined with Aligned PCL/PLGA Electrospun Material

    PubMed Central

    Yang, Chao; Li, Lei; Xiong, Jie; Xie, Li; Yang, Bo; Yu, Mei; Feng, Lian; Jiang, Zongting; Guo, Weihua; Tian, Weidong

    2015-01-01

    Stem cell implantation has been utilized for the repair of spinal cord injury; however, it shows unsatisfactory performance in repairing large scale lesion of an organ. We hypothesized that dental follicle cells (DFCs), which possess multipotential capability, could reconstruct spinal cord defect (SCD) in combination with biomaterials. In the present study, mesenchymal and neurogenic lineage characteristics of human DFCs (hDFCs) were identified. Aligned electrospun PCL/PLGA material (AEM) was fabricated and it would not lead to cytotoxic reaction; furthermore, hDFCs could stretch along the oriented fibers and proliferate efficiently on AEM. Subsequently, hDFCs seeded AEM was transplanted to restore the defect in rat spinal cord. Functional observation was performed but results showed no statistical significance. The following histologic analyses proved that AEM allowed nerve fibers to pass through, and implanted hDFCs could express oligodendrogenic lineage maker Olig2 in vivo which was able to contribute to remyelination. Therefore, we concluded that hDFCs can be a candidate resource in neural regeneration. Aligned electrospun fibers can support spinal cord structure and induce cell/tissue polarity. This strategy can be considered as alternative proposals for the SCD regeneration studies. PMID:25695050

  16. Quality improvement education to improve performance on ulcerative colitis quality measures and care processes aligned with National Quality Strategy priorities.

    PubMed

    Greene, Laurence; Moreo, Kathleen

    2015-01-01

    Studies on inflammatory bowel disease (IBD) have reported suboptimal approaches to patient care. In the United States, the findings have motivated leading gastroenterology organizations to call for initiatives that support clinicians in aligning their practices with quality measures for IBD and priorities of the National Quality Strategy (NQS). We designed and implemented a quality improvement (QI) education program on ulcerative colitis in which patient charts were audited for 30 gastroenterologists before (n = 300 charts) and after (n = 290 charts) they participated in QI-focused educational activities. Charts were audited for nine measures, selected for their alignment with four NQS priorities: making care safer, ensuring patient engagement, promoting communication, and promoting effective treatment practices. Four of the measures, including guideline-directed vaccinations and assessments of disease type and activity, were part of the CMS Physician Quality Reporting System (PQRS). The other five measures involved counseling patients on various topics in ulcerative colitis management, documentation of side effects, assessment of adherence status, and simplification of dosing. The gastroenterologists also completed baseline and post-education surveys designed to assess qualitative outcomes. One of the educational interventions was a private audit feedback session conducted for each gastroenterologist. The sessions were designed to support participants in identifying measures reflecting suboptimal care quality and developing action plans for improvement. In continuous improvement cycles, follow-up interventions included QI tools and educational monographs. Across the nine chart variables, post-education improvements ranged from 0% to 48%, with a mean improvement of 15.9%. Survey findings revealed improvements in self-reported understanding of quality measures and intentions to apply them to practice, and lower rates of perceived significant barriers to high-quality care. The findings indicate the potential for QI education to support gastroenterologists in improving their performance on key measures of care quality for patients with ulcerative colitis. PMID:26732044

  17. Quality improvement education to improve performance on ulcerative colitis quality measures and care processes aligned with National Quality Strategy priorities

    PubMed Central

    Greene, Laurence; Moreo, Kathleen

    2015-01-01

    Studies on inflammatory bowel disease (IBD) have reported suboptimal approaches to patient care. In the United States, the findings have motivated leading gastroenterology organizations to call for initiatives that support clinicians in aligning their practices with quality measures for IBD and priorities of the National Quality Strategy (NQS). We designed and implemented a quality improvement (QI) education program on ulcerative colitis in which patient charts were audited for 30 gastroenterologists before (n = 300 charts) and after (n = 290 charts) they participated in QI-focused educational activities. Charts were audited for nine measures, selected for their alignment with four NQS priorities: making care safer, ensuring patient engagement, promoting communication, and promoting effective treatment practices. Four of the measures, including guideline-directed vaccinations and assessments of disease type and activity, were part of the CMS Physician Quality Reporting System (PQRS). The other five measures involved counseling patients on various topics in ulcerative colitis management, documentation of side effects, assessment of adherence status, and simplification of dosing. The gastroenterologists also completed baseline and post-education surveys designed to assess qualitative outcomes. One of the educational interventions was a private audit feedback session conducted for each gastroenterologist. The sessions were designed to support participants in identifying measures reflecting suboptimal care quality and developing action plans for improvement. In continuous improvement cycles, follow-up interventions included QI tools and educational monographs. Across the nine chart variables, post-education improvements ranged from 0% to 48%, with a mean improvement of 15.9%. Survey findings revealed improvements in self-reported understanding of quality measures and intentions to apply them to practice, and lower rates of perceived significant barriers to high-quality care. The findings indicate the potential for QI education to support gastroenterologists in improving their performance on key measures of care quality for patients with ulcerative colitis.

  18. History: Cooling and societal change

    NASA Astrophysics Data System (ADS)

    Haldon, John

    2016-03-01

    The rise and fall of civilizations over the past two millennia was set against a backdrop of climate change. High-resolution climate records evince a link between societal change and a period of cooling in the sixth and seventh centuries.

  19. "Children's Digest" and Societal Trends.

    ERIC Educational Resources Information Center

    Eckart, Karen Sue

    The purpose of this research project was to determine if, like books, the content of children's magazines changes to reflect current societal trends. The study used the method of content analysis and was limited to one children's magazine, "Children's Digest." Certain trends in children's literature were identified through the literature search,…

  20. Societal Development and Social Change

    ERIC Educational Resources Information Center

    Nderu-Boddington, Eulalee

    2008-01-01

    This article compares and contrasts the theories of three major writers on societal change: Chirot discusses the economic power struggles within and among core, peripheral, and semiperipheral societies, Toffler exposes a future in which major power shifts could have cataclysmic results, and Bruner emphasizes the importance of education to temper…

  1. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.

    PubMed

    Thompson, J D; Gibson, T J; Plewniak, F; Jeanmougin, F; Higgins, D G

    1997-12-15

    CLUSTAL X is a new windows interface for the widely-used progressive multiple sequence alignment program CLUSTAL W. The new system is easy to use, providing an integrated system for performing multiple sequence and profile alignments and analysing the results. CLUSTAL X displays the sequence alignment in a window on the screen. A versatile sequence colouring scheme allows the user to highlight conserved features in the alignment. Pull-down menus provide all the options required for traditional multiple sequence and profile alignment. New features include: the ability to cut-and-paste sequences to change the order of the alignment, selection of a subset of the sequences to be realigned, and selection of a sub-range of the alignment to be realigned and inserted back into the original alignment. Alignment quality analysis can be performed and low-scoring segments or exceptional residues can be highlighted. Quality analysis and realignment of selected residue ranges provide the user with a powerful tool to improve and refine difficult alignments and to trap errors in input sequences. CLUSTAL X has been compiled on SUN Solaris, IRIX5.3 on Silicon Graphics, Digital UNIX on DECstations, Microsoft Windows (32 bit) for PCs, Linux ELF for x86 PCs, and Macintosh PowerMac. PMID:9396791

  2. Individual Empowerment. Global Societal Trends to 2030: Thematic Report 3

    ERIC Educational Resources Information Center

    Graf, Marlon; Ghez, Jeremy; Khodyakov, Dmitry; Yaqub, Ohid

    2015-01-01

    This Research Report forms part of our series on global societal trends and their impact on the EU in 2030. This analysis is embedded within the framework of the European Strategy and Policy Analysis System (ESPAS) set up to develop a lasting framework to assess global trends and to develop policy responses across EU institutions over the next…

  3. Individual Empowerment. Global Societal Trends to 2030: Thematic Report 3

    ERIC Educational Resources Information Center

    Graf, Marlon; Ghez, Jeremy; Khodyakov, Dmitry; Yaqub, Ohid

    2015-01-01

    This Research Report forms part of our series on global societal trends and their impact on the EU in 2030. This analysis is embedded within the framework of the European Strategy and Policy Analysis System (ESPAS) set up to develop a lasting framework to assess global trends and to develop policy responses across EU institutions over the next…

  4. Practical study on the electron-beam-only alignment strategy for the electron beam direct writing technology

    NASA Astrophysics Data System (ADS)

    Kojima, Yoshinori; Takahashi, Yasushi; Ohshio, Shuzo; Sugatani, Shinji; Kon, Junichi

    2013-03-01

    Techniques to introduce of electron beam direct writing (EBDW) technology into the volume production lines for the 65 nm process technology are shown and discussed. In order to apply these techniques in a harmonious way, partial modifications to the current production line infrastructures are required, because those infrastructures have been optimized for the conventional photolithography technology. One of the large differences is with the alignment. For the gate layer, the appropriate solution is to have an additional process step to remove SiO2 material filled in the shallow trench isolation alignment marks before the patterning. For the dual damascene process at the metal layers, careful consideration of the choice between the indirect alignment or the direct alignment is necessary, when the metal layer is aligned to the previous via layer underneath. We expect that these techniques can be used for the advanced node devices as well, while some new structures would be applied on these devices. In addition to the optimizing the alignment mark structures, the appropriate adjustment of EBDW system parameters by advanced process control (APC) is required, in order to have enough overlay accuracy at the actual production use. Although such process control systems are normally optimized to photolithography, we have confirmed that APC system can be also used for the EBDW technology for appropriate overlay accuracy control. Furthermore, the alignment budget in our systems is created and the alignment accuracy in our future system is estimated based on it. Based on the findings from these discussions, we expect that the EBDW with e-beam-only alignment will be applicable for the production of the 11 nm half-pitch process technology node and the beyond.

  5. Strategy-aligned fuzzy approach for market segment evaluation and selection: a modular decision support system by dynamic network process (DNP)

    NASA Astrophysics Data System (ADS)

    Mohammadi Nasrabadi, Ali; Hosseinpour, Mohammad Hossein; Ebrahimnejad, Sadoullah

    2013-05-01

    In competitive markets, market segmentation is a critical point of business, and it can be used as a generic strategy. In each segment, strategies lead companies to their targets; thus, segment selection and the application of the appropriate strategies over time are very important to achieve successful business. This paper aims to model a strategy-aligned fuzzy approach to market segment evaluation and selection. A modular decision support system (DSS) is developed to select an optimum segment with its appropriate strategies. The suggested DSS has two main modules. The first one is SPACE matrix which indicates the risk of each segment. Also, it determines the long-term strategies. The second module finds the most preferred segment-strategies over time. Dynamic network process is applied to prioritize segment-strategies according to five competitive force factors. There is vagueness in pairwise comparisons, and this vagueness has been modeled using fuzzy concepts. To clarify, an example is illustrated by a case study in Iran's coffee market. The results show that success possibility of segments could be different, and choosing the best ones could help companies to be sure in developing their business. Moreover, changing the priority of strategies over time indicates the importance of long-term planning. This fact has been supported by a case study on strategic priority difference in short- and long-term consideration.

  6. Survey research and societal change.

    PubMed

    Tourangeau, Roger

    2004-01-01

    Surveys reflect societal change in a way that few other research tools do. Over the past two decades, three developments have transformed surveys. First, survey organizations have adopted new methods for selecting telephone samples; these new methods were made possible by the creation of large databases that include all listed telephone numbers in the United States. A second development has been the widespread decline in response rates for all types of surveys. In the face of this problem, survey researchers have developed new theories of nonresponse that build on the persuasion literature in social psychology. Finally, surveys have adopted many new methods of data collection; the new modes reflect technological developments in computing and the emergence of the Internet. Research has spawned several theories that examine how characteristics of the data collection method shape the answers obtained. Rapid change in survey methods is likely to continue in the coming years. PMID:14744234

  7. Cultural diversity, economic development and societal instability

    USGS Publications Warehouse

    Nettle, D.; Grace, J.B.; Choisy, M.; Cornell, H.V.; Guegan, J.-F.; Hochberg, M.E.

    2007-01-01

    Background. Social scientists have suggested that cultural diversity in a nation leads to societal instability. However, societal instability may be affected not only by within-nation on ?? diversity, but also diversity between a nation and its neighbours or ?? diversity. It is also necessary to distinguish different domains of diversity, namely linguistic, ethnic and religious, and to distinguish between the direct effects of diversity on societal instability, and effects that are mediated by economic conditions. Methodology/Principal Findings. We assembled a large cross-national dataset with information on ?? and ?? cultural diversity, economic conditions, and indices of societal instability. Structural equation modeling was used to evaluate the direct and indirect effects of cultural diversity on economics and societal stability. Results show that different type and domains of diversity have interacting effects. As previously documented, linguistic ?? diversity has a negative effect on economic performance, and we show that it is largely through this economic mechanism that it affects societal instability. For ?? diversity, the higher the linguistic diversity among nations in a region, the less stable the nation. But, religious ?? diversity has the opposite effect, reducing instability, particularly in the presence of high linguistic diversity. Conclusions. Within-nation linguistic diversity is associated with reduced economic performance, which, in turn, increases societal instability. Nations which differ linguistically from their neighbors are also less stable. However, religious diversity between, neighboring nations has the opposite effect, decreasing societal instability.

  8. Cultural Diversity, Economic Development and Societal Instability

    PubMed Central

    Nettle, Daniel; Grace, James B.; Choisy, Marc; Cornell, Howard V.; Guégan, Jean-François; Hochberg, Michael E.

    2007-01-01

    Background Social scientists have suggested that cultural diversity in a nation leads to societal instability. However, societal instability may be affected not only by within-nation or ? diversity, but also diversity between a nation and its neighbours or ? diversity. It is also necessary to distinguish different domains of diversity, namely linguistic, ethnic and religious, and to distinguish between the direct effects of diversity on societal instability, and effects that are mediated by economic conditions. Methodology/Principal Findings We assembled a large cross-national dataset with information on ? and ? cultural diversity, economic conditions, and indices of societal instability. Structural equation modeling was used to evaluate the direct and indirect effects of cultural diversity on economics and societal stability. Results show that different types and domains of diversity have interacting effects. As previously documented, linguistic ? diversity has a negative effect on economic performance, and we show that it is largely through this economic mechanism that it affects societal instability. For ? diversity, the higher the linguistic diversity among nations in a region, the less stable the nation. But, religious ? diversity has the opposite effect, reducing instability, particularly in the presence of high linguistic diversity. Conclusions Within-nation linguistic diversity is associated with reduced economic performance, which, in turn, increases societal instability. Nations which differ linguistically from their neighbors are also less stable. However, religious diversity between neighboring nations has the opposite effect, decreasing societal instability. PMID:17895970

  9. MC64-ClustalWP2: a highly-parallel hybrid strategy to align multiple sequences in many-core architectures.

    PubMed

    Díaz, David; Esteban, Francisco J; Hernández, Pilar; Caballero, Juan Antonio; Guevara, Antonio; Dorado, Gabriel; Gálvez, Sergio

    2014-01-01

    We have developed the MC64-ClustalWP2 as a new implementation of the Clustal W algorithm, integrating a novel parallelization strategy and significantly increasing the performance when aligning long sequences in architectures with many cores. It must be stressed that in such a process, the detailed analysis of both the software and hardware features and peculiarities is of paramount importance to reveal key points to exploit and optimize the full potential of parallelism in many-core CPU systems. The new parallelization approach has focused into the most time-consuming stages of this algorithm. In particular, the so-called progressive alignment has drastically improved the performance, due to a fine-grained approach where the forward and backward loops were unrolled and parallelized. Another key approach has been the implementation of the new algorithm in a hybrid-computing system, integrating both an Intel Xeon multi-core CPU and a Tilera Tile64 many-core card. A comparison with other Clustal W implementations reveals the high-performance of the new algorithm and strategy in many-core CPU architectures, in a scenario where the sequences to align are relatively long (more than 10 kb) and, hence, a many-core GPU hardware cannot be used. Thus, the MC64-ClustalWP2 runs multiple alignments more than 18x than the original Clustal W algorithm, and more than 7x than the best x86 parallel implementation to date, being publicly available through a web service. Besides, these developments have been deployed in cost-effective personal computers and should be useful for life-science researchers, including the identification of identities and differences for mutation/polymorphism analyses, biodiversity and evolutionary studies and for the development of molecular markers for paternity testing, germplasm management and protection, to assist breeding, illegal traffic control, fraud prevention and for the protection of the intellectual property (identification/traceability), including the protected designation of origin, among other applications. PMID:24710354

  10. MC64-ClustalWP2: A Highly-Parallel Hybrid Strategy to Align Multiple Sequences in Many-Core Architectures

    PubMed Central

    Díaz, David; Esteban, Francisco J.; Hernández, Pilar; Caballero, Juan Antonio; Guevara, Antonio

    2014-01-01

    We have developed the MC64-ClustalWP2 as a new implementation of the Clustal W algorithm, integrating a novel parallelization strategy and significantly increasing the performance when aligning long sequences in architectures with many cores. It must be stressed that in such a process, the detailed analysis of both the software and hardware features and peculiarities is of paramount importance to reveal key points to exploit and optimize the full potential of parallelism in many-core CPU systems. The new parallelization approach has focused into the most time-consuming stages of this algorithm. In particular, the so-called progressive alignment has drastically improved the performance, due to a fine-grained approach where the forward and backward loops were unrolled and parallelized. Another key approach has been the implementation of the new algorithm in a hybrid-computing system, integrating both an Intel Xeon multi-core CPU and a Tilera Tile64 many-core card. A comparison with other Clustal W implementations reveals the high-performance of the new algorithm and strategy in many-core CPU architectures, in a scenario where the sequences to align are relatively long (more than 10 kb) and, hence, a many-core GPU hardware cannot be used. Thus, the MC64-ClustalWP2 runs multiple alignments more than 18x than the original Clustal W algorithm, and more than 7x than the best x86 parallel implementation to date, being publicly available through a web service. Besides, these developments have been deployed in cost-effective personal computers and should be useful for life-science researchers, including the identification of identities and differences for mutation/polymorphism analyses, biodiversity and evolutionary studies and for the development of molecular markers for paternity testing, germplasm management and protection, to assist breeding, illegal traffic control, fraud prevention and for the protection of the intellectual property (identification/traceability), including the protected designation of origin, among other applications. PMID:24710354

  11. Societal health and urban sustainability indicators

    SciTech Connect

    Petrich, C.H.; Tonn, B.E.

    1996-08-27

    Without the social will, no city can successfully Undertake the planning and programs necessary for meaningful progress toward sustainability. Social will derives from wellsprings of vital societal health. This paper presents an approach to helping cities in APEC member economies initiate a program for developing indicators of sustainability. Representative indicators of social capital and other aspects of civic engagement, as proxies for societal health, are presented.

  12. The effect of recent trends in vehicle design on U.S. societal fatality risk per vehicle mile traveled, and their projected future relationship with vehicle mass.

    PubMed

    Wenzel, Tom

    2013-07-01

    The National Highway Traffic Safety Administration (NHTSA) recently updated its 2003 and 2010 logistic regression analyses of the effect of a reduction in light-duty vehicle mass on US fatality risk per vehicle mile traveled (VMT). The current NHTSA analysis is the most thorough investigation of this issue to date. LBNL's assessment of the analysis indicates that the estimated effect of mass reduction on risk is smaller than in the previous studies, and statistically non-significant for all but the lightest cars. The effects three recent trends in vehicle designs and technologies have on societal fatality risk per VMT are estimated, and whether these changes might affect the relationship between vehicle mass and fatality risk in the future. Side airbags are found to reduce fatality risk in cars, but not necessarily light trucks or CUVs/minivans, struck in the side by another light-duty vehicle; reducing the number of fatalities in cars struck in the side is predicted to reduce the estimated detrimental effect of footprint reduction, but increase the detrimental effect of mass reduction, in cars on societal fatality risk. Better alignment of light truck bumpers with those of other vehicles appears to result in a statistically significant reduction in risk imposed on car occupants; however, reducing this type of fatality will likely have little impact on the estimated effect of mass or footprint reduction on risk. Finally, shifting light truck drivers into safer, car-based vehicles, such as sedans, CUVs, and minivans, would result in larger reductions in societal fatalities than expected from even substantial reductions in the masses of light trucks. A strategy of shifting drivers from truck-based to car-based vehicles would reduce fuel use and greenhouse gas emissions, while improving societal safety. PMID:23631906

  13. Making Health System Performance Measurement Useful to Policy Makers: Aligning Strategies, Measurement and Local Health System Accountability in Ontario

    PubMed Central

    Veillard, Jeremy; Huynh, Tai; Ardal, Sten; Kadandale, Sowmya; Klazinga, Niek S.; Brown, Adalsteinn D.

    2010-01-01

    This study examined the experience of the Ontario Ministry of Health and Long-Term Care in enhancing its stewardship and performance management role by developing a health system strategy map and a strategy-based scorecard through a process of policy reviews and expert consultations, and linking them to accountability agreements. An evaluation of the implementation and of the effects of the policy intervention has been carried out through direct policy observation over three years, document analysis, interviews with decision-makers and systematic discussion of findings with other authors and external reviewers. Cascading strategies at health and local health system levels were identified, and a core set of health system and local health system performance indicators was selected and incorporated into accountability agreements with the Local Health Integration Networks. despite the persistence of such challenges as measurement limitations and lack of systematic linkage to decision-making processes, these activities helped to strengthen substantially the ministry's performance management function. PMID:21286268

  14. Integration of Aerial and long-range Terrestrial Laser Scanner: alignment strategies and 3D models for landslide/rockslide description

    NASA Astrophysics Data System (ADS)

    Bertacchini, Eleonora; Rivola, Riccardo; Castagnetti, Cristina; Capra, Alessandro; Parmeggiani, Erika

    2013-04-01

    The purpose of this work is to integrate airborne and long-range (up to some kilometers) terrestrial laser scanning data in order to obtain a good and reliable description of the geomorphology of unstable slopes. 3D models derived from the integrated point clouds can be particularly useful to study and analyze complex morphology, vertical walls of rockslides and surfaces with sparse vegetation. Terrestrial Laser Scanning (TLS) and Airborne Laser Scanning (ALS) are very efficient techniques for characterizing the morphostructure of slopes; although both techniques individually show some limits, their integration can overcome these limits. For example, for vertical walls of rock, the TLS could be recommended because of its "frontal" point of view, that permits a description of vertical walls with a higher point density than ALS can reach. On the other hand, the power of the ALS methodology is highlighted when a large and flat area is involved and/or when a lot of vegetation covers the area. The ALS can easily reach the ground with respect to TLS due to its vertical position of measurement and this allows a more reliable result even if the last generation of terrestrial laser scanners has the skill to penetrate inside the vegetation thanks to a multi-echo technology. All the problems and difficulties encountered will be fully described. When a reliable description of the morphology is requested and involved distances are of some kilometers, the alignment strategies, the point cloud management and filtering, along with the DTM generation are crucial aspects that cannot be underestimate. Thus, different alignment techniques were examined (ICP - Iterative Closest Point, backsigthing orientation with GPS positioning, alignment with targets or homologous points). Results could be optimized only combining the different alignment approaches. In addition, the DTM generation was deeply analyzed, comparing TIN (Triangular Irregular Network) and grid mesh format, different point cloud densities, different grid dimensions and algorithms of interpolation. The challenge was the definition of a quantitative method for comparing 3D models obtained with the different approaches.

  15. Aligned-or Not?

    ERIC Educational Resources Information Center

    Roseman, Jo Ellen; Koppal, Mary

    2015-01-01

    When state leaders and national partners in the development of the Next Generation Science Standards met to consider implementation strategies, states and school districts wanted to know which materials were aligned to the new standards. The answer from the developers was short but not sweet: You won't find much now, and it's going to…

  16. Aligned-or Not?

    ERIC Educational Resources Information Center

    Roseman, Jo Ellen; Koppal, Mary

    2015-01-01

    When state leaders and national partners in the development of the Next Generation Science Standards met to consider implementation strategies, states and school districts wanted to know which materials were aligned to the new standards. The answer from the developers was short but not sweet: You won't find much now, and it's going to…

  17. Atomoxetine's Effect on Societal Costs in Sweden

    ERIC Educational Resources Information Center

    Myren, Karl-Johan; Thernlund, Gunilla; Nylen, Asa; Schacht, Alexander; Svanborg, Par

    2010-01-01

    Objective: To compare societal costs between patients treated with atomoxetine and placebo in Sweden. Method: Ninety-nine pediatric ADHD patients were randomized to a 10-week double-blind treatment with atomoxetine (n = 49) or placebo (n = 50). All parents received four sessions of psycho-education. Parents filled out a resource utilization…

  18. Atomoxetine's Effect on Societal Costs in Sweden

    ERIC Educational Resources Information Center

    Myren, Karl-Johan; Thernlund, Gunilla; Nylen, Asa; Schacht, Alexander; Svanborg, Par

    2010-01-01

    Objective: To compare societal costs between patients treated with atomoxetine and placebo in Sweden. Method: Ninety-nine pediatric ADHD patients were randomized to a 10-week double-blind treatment with atomoxetine (n = 49) or placebo (n = 50). All parents received four sessions of psycho-education. Parents filled out a resource utilization…

  19. The societal impact value of risk

    SciTech Connect

    Simpson, D.E.

    1995-04-01

    A key ill-defined issue in the management and regulation of potentially hazardous conditions is that of the value to be associated with a reduction (or existence) of human health risks, such as radiation exposure or hazardous substance ingestion. Empirical observations of societal behavior patterns lead to a relationship for the quantitative value of societal risk impact which is consistent with general societal risk acceptance, is not inconsistent with ``de facto`` risk regulation, and is suitable and appropriate as a specification or guide for risk management and risk regulation. This societal risk impact expression is: Impact ($/year) = (8 {times} 10{sup 7}) NR{sub i}{sup 4/3} where Ri = individual annual mortality risk; N = number of persons in the population sharing the risk and benefits. The change in Impact which can be derived from a regulation or risk management activity is the value of annual benefit which society would expect to forego (or annual equivalent cost to incur) in consideration of the activity.

  20. Alignment validation

    SciTech Connect

    ALICE; ATLAS; CMS; LHCb; Golling, Tobias

    2008-09-06

    The four experiments, ALICE, ATLAS, CMS and LHCb are currently under constructionat CERN. They will study the products of proton-proton collisions at the Large Hadron Collider. All experiments are equipped with sophisticated tracking systems, unprecedented in size and complexity. Full exploitation of both the inner detector andthe muon system requires an accurate alignment of all detector elements. Alignmentinformation is deduced from dedicated hardware alignment systems and the reconstruction of charged particles. However, the system is degenerate which means the data is insufficient to constrain all alignment degrees of freedom, so the techniques are prone to converging on wrong geometries. This deficiency necessitates validation and monitoring of the alignment. An exhaustive discussion of means to validate is subject to this document, including examples and plans from all four LHC experiments, as well as other high energy experiments.

  1. Societal landslide and flood risk in Italy

    NASA Astrophysics Data System (ADS)

    Salvati, P.; Bianchi, C.; Rossi, M.; Guzzetti, F.

    2010-03-01

    We assessed societal landslide and flood risk to the population of Italy. The assessment was conducted at the national (synoptic) and at the regional scales. For the assessment, we used an improved version of the catalogue of historical landslide and flood events that have resulted in loss of life, missing persons, injuries and homelessness in Italy, from 1850 to 2008. This is the recent portion of a larger catalogue spanning the 1941-year period from 68 to 2008. We started by discussing uncertainty and completeness in the historical catalogue, and we performed an analysis of the temporal and geographical pattern of harmful landslide and flood events, in Italy. We found that sites affected by harmful landslides or floods are not distributed evenly in Italy, and we attributed the differences to different physiographical settings. To determine societal risk, we investigated the distribution of the number of landslide and flood casualties (deaths, missing persons, and injured people) in Italy, and in the 20 Italian Regions. Using order statistics, we found that the intensity of a landslide or flood event - measured by the total number of casualties in the event - follows a general negative power law trend. Next, we modelled the empirical distributions of the frequency of landslide and flood events with casualties in Italy and in each Region using a Zipf distribution. We used the scaling exponent s of the probability mass function (PMF) of the intensity of the events, which controls the proportion of small, medium, and large events, to compare societal risk levels in different geographical areas and for different periods. Lastly, to consider the frequency of the events with casualties, we scaled the PMF obtained for the individual Regions to the total number of events in each Region, in the period 1950-2008, and we used the results to rank societal landslide and flood risk in Italy. We found that in the considered period societal landslide risk is largest in Trentino-Alto Adige and Campania, and societal flood risk is highest in Piedmont and Sicily.

  2. Accurate and rapid alignment of laser scanned 3D surface using TSK-type neural-fuzzy network-based coarse-to-fine strategy

    NASA Astrophysics Data System (ADS)

    Chang, Jyun-Wei; Lin, Sheng-Fuu; Hsu, Chi-Yao

    2012-10-01

    Aligning a laser scanned three-dimensional (3D) surface is considered a critical step in object recognition, shape analysis, and automatic visual inspection. Two major concerns for the alignment task are execution time and alignment accuracy. Recently, neural network-based methods have become very popular due to their high efficiency. However, such methods experience difficulty in reaching high accuracy because the use of principal component analysis (PCA) to perform coarse alignment causes a large alignment error. Thus, a TSK-type neural-fuzzy network (TNFN)-based coarse-to-fine 3D surface alignment scheme is proposed in the current paper. Compared with traditional neural network-based approaches, the proposed method provides a coarse-to-fine alignment approach to ensure the accurate pose estimated by TNFN in the coarse phase, as well the high alignment speed provided by TNFN-based surface modeling in the fine phase. Experimental results demonstrate the superior performance of the proposed 3D surface alignment system over existing systems.

  3. Education, Technology and Connectedness. Global Societal Trends to 2030: Thematic Report 2

    ERIC Educational Resources Information Center

    Horvath, Veronika; Ghez, Jeremy; Khodyakov, Dmitry; Yaqub, Ohid

    2015-01-01

    This Research Report forms part of our series on global societal trends and their impact on the EU in 2030. This analysis is embedded within the framework of the European Strategy and Policy Analysis System (ESPAS) set up to develop a lasting framework to assess global trends and to develop policy responses across EU institutions over the next…

  4. Education, Technology and Connectedness. Global Societal Trends to 2030: Thematic Report 2

    ERIC Educational Resources Information Center

    Horvath, Veronika; Ghez, Jeremy; Khodyakov, Dmitry; Yaqub, Ohid

    2015-01-01

    This Research Report forms part of our series on global societal trends and their impact on the EU in 2030. This analysis is embedded within the framework of the European Strategy and Policy Analysis System (ESPAS) set up to develop a lasting framework to assess global trends and to develop policy responses across EU institutions over the next…

  5. Awareness of Societal Issues Among High School Biology Teachers Teaching Genetics

    NASA Astrophysics Data System (ADS)

    Lazarowitz, Reuven; Bloch, Ilit

    2005-12-01

    The purpose of this study was to investigate how aware high school biology teachers are of societal issues (values, moral, ethic, and legal issues) while teaching genetics, genetics engineering, molecular genetics, human heredity, and evolution. The study includes a short historical review of World War II atrocities during the Holocaust when scientists from all the above-mentioned disciplines had been involved in trying to support and develop the eugenics theories. It investigates pre- and postwar theories of the eugenics movement in the United States which were implemented successfully in Germany and a literature survey of the studies of societal issues related to these subjects. The sample consisted of 30 male and female biology teachers. Enclosed are teachers' answers in favor or against including debates about societal issues in their classrooms while teaching the disciplines mentioned above. Teachers' answers were analyzed in relation to three variables: years of teaching experience, gender, and religion faith. Data were collected from questionnaires and personal interviews and analyzed according to qualitative and quantitative methods. The results show that amongst the teachers there is a medium to low level of awareness of societal issues, while mainly emphasizing scientific subjects in preparation of matriculation examinations. The majority of the teachers do not include societal issues in their teaching, but if students raise these issues, teachers claimed to address them. No differences in teachers' opinions to societal issues were found in relation to gender or religious faith. Teachers with more years of teaching experience tend to teach with a more Science, Technology, and Society (STS) approach than novice teachers. The results are discussed in relation to teachers' professional development and teaching strategies are suggested to be used in their classrooms based on a STS approach, which includes the societal issues as a main goal.

  6. Alignment fixture

    DOEpatents

    Bell, Grover C. (Norris, TN); Gibson, O. Theodore (Lenoir City, TN)

    1980-01-01

    A part alignment fixture is provided which may be used for precise variable lateral and tilt alignment relative to the fixture base of various shaped parts. The fixture may be used as a part holder for machining or inspection of parts or alignment of parts during assembly and the like. The fixture includes a precisely machined diameter disc-shaped hub adapted to receive the part to be aligned. The hub is nested in a guide plate which is adapted to carry two oppositely disposed pairs of positioning wedges so that the wedges may be reciprocatively positioned by means of respective micrometer screws. The sloping faces of the wedges contact the hub at respective quadrants of the hub periphery. The lateral position of the hub relative to the guide plate is adjusted by positioning the wedges with the associated micrometer screws. The tilt of the part is adjusted relative to a base plate, to which the guide plate is pivotally connected by means of a holding plate. Two pairs of oppositely disposed wedges are mounted for reciprocative lateral positioning by means of separate micrometer screws between flanges of the guide plate and the base plate. Once the wedges are positioned to achieve the proper tilt of the part or hub on which the part is mounted relative to the base plate, the fixture may be bolted to a machining, inspection, or assembly device.

  7. Curriculum Alignment.

    ERIC Educational Resources Information Center

    Crowell, Ronald; Tissot, Paula

    Curriculum alignment (CA) refers to the congruence of all the elements of a school's curriculum: curriculum goals; instructional program--what is taught and the materials used; and tests used to judge outcomes. CA can be a very powerful can be a very powerful factor in improving schools. Although further research is needed on CA, there is…

  8. Improvement of the Thermostability and Activity of a Pectate Lyase by Single Amino Acid Substitutions, Using a Strategy Based on Melting-Temperature-Guided Sequence Alignment? †

    PubMed Central

    Xiao, Zhizhuang; Bergeron, Hélène; Grosse, Stephan; Beauchemin, Manon; Garron, Marie-Line; Shaya, David; Sulea, Traian; Cygler, Miroslaw; Lau, Peter C. K.

    2008-01-01

    In the vast number of random mutagenesis experiments that have targeted protein thermostability, single amino acid substitutions that increase the apparent melting temperature (Tm) of the enzyme more than 1 to 2°C are rare and often require the creation of a large library of mutated genes. Here we present a case where a single beneficial mutation (R236F) of a hemp fiber-processing pectate lyase of Xanthomonas campestris origin (PLXc) produced a 6°C increase in Tm and a 23-fold increase in the half-life at 45°C without compromising the enzyme's catalytic efficiency. This success was based on a variation of sequence alignment strategy where a mesophilic amino acid sequence is matched with the sequences of its thermophilic counterparts that have established Tm values. Altogether, two-thirds of the nine targeted single amino acid substitutions were found to have effects either on the thermostability or on the catalytic activity of the enzyme, evidence of a high success rate of mutation without the creation of a large gene library and subsequent screening of clones. Combination of R236F with another beneficial mutation (A31G) resulted in at least a twofold increase in specific activity while preserving the improved Tm value. To understand the structural basis for the increased thermal stability or activity, the variant R236F and A31G R236F proteins and wild-type PLXc were purified and crystallized. By structure analysis and computational methods, hydrophobic desolvation was found to be the driving force for the increased stability with R236F. PMID:18156340

  9. Image alignment

    DOEpatents

    Dowell, Larry Jonathan

    2014-04-22

    Disclosed is a method and device for aligning at least two digital images. An embodiment may use frequency-domain transforms of small tiles created from each image to identify substantially similar, "distinguishing" features within each of the images, and then align the images together based on the location of the distinguishing features. To accomplish this, an embodiment may create equal sized tile sub-images for each image. A "key" for each tile may be created by performing a frequency-domain transform calculation on each tile. A information-distance difference between each possible pair of tiles on each image may be calculated to identify distinguishing features. From analysis of the information-distance differences of the pairs of tiles, a subset of tiles with high discrimination metrics in relation to other tiles may be located for each image. The subset of distinguishing tiles for each image may then be compared to locate tiles with substantially similar keys and/or information-distance metrics to other tiles of other images. Once similar tiles are located for each image, the images may be aligned in relation to the identified similar tiles.

  10. MUSE optical alignment procedure

    NASA Astrophysics Data System (ADS)

    Laurent, Florence; Renault, Edgard; Loupias, Magali; Kosmalski, Johan; Anwand, Heiko; Bacon, Roland; Boudon, Didier; Caillier, Patrick; Daguisé, Eric; Dubois, Jean-Pierre; Dupuy, Christophe; Kelz, Andreas; Lizon, Jean-Louis; Nicklas, Harald; Parès, Laurent; Remillieux, Alban; Seifert, Walter; Valentin, Hervé; Xu, Wenli

    2012-09-01

    MUSE (Multi Unit Spectroscopic Explorer) is a second generation VLT integral field spectrograph (1x1arcmin² Field of View) developed for the European Southern Observatory (ESO), operating in the visible wavelength range (0.465-0.93 μm). A consortium of seven institutes is currently assembling and testing MUSE in the Integration Hall of the Observatoire de Lyon for the Preliminary Acceptance in Europe, scheduled for 2013. MUSE is composed of several subsystems which are under the responsibility of each institute. The Fore Optics derotates and anamorphoses the image at the focal plane. A Splitting and Relay Optics feed the 24 identical Integral Field Units (IFU), that are mounted within a large monolithic instrument mechanical structure. Each IFU incorporates an image slicer, a fully refractive spectrograph with VPH-grating and a detector system connected to a global vacuum and cryogenic system. During 2011, all MUSE subsystems were integrated, aligned and tested independently in each institute. After validations, the systems were shipped to the P.I. institute at Lyon and were assembled in the Integration Hall This paper describes the end-to-end optical alignment procedure of the MUSE instrument. The design strategy, mixing an optical alignment by manufacturing (plug and play approach) and few adjustments on key components, is presented. We depict the alignment method for identifying the optical axis using several references located in pupil and image planes. All tools required to perform the global alignment between each subsystem are described. The success of this alignment approach is demonstrated by the good results for the MUSE image quality. MUSE commissioning at the VLT (Very Large Telescope) is planned for 2013.

  11. Genetic Diversity and Societally Important Disparities

    PubMed Central

    Rosenberg, Noah A.; Kang, Jonathan T. L.

    2015-01-01

    The magnitude of genetic diversity within human populations varies in a way that reflects the sequence of migrations by which people spread throughout the world. Beyond its use in human evolutionary genetics, worldwide variation in genetic diversity sometimes can interact with social processes to produce differences among populations in their relationship to modern societal problems. We review the consequences of genetic diversity differences in the settings of familial identification in forensic genetic testing, match probabilities in bone marrow transplantation, and representation in genome-wide association studies of disease. In each of these three cases, the contribution of genetic diversity to social differences follows from population-genetic principles. For a fourth setting that is not similarly grounded, we reanalyze with expanded genetic data a report that genetic diversity differences influence global patterns of human economic development, finding no support for the claim. The four examples describe a limit to the importance of genetic diversity for explaining societal differences while illustrating a distinction that certain biologically based scenarios do require consideration of genetic diversity for solving problems to which populations have been differentially predisposed by the unique history of human migrations. PMID:26354973

  12. Genetic Diversity and Societally Important Disparities.

    PubMed

    Rosenberg, Noah A; Kang, Jonathan T L

    2015-09-01

    The magnitude of genetic diversity within human populations varies in a way that reflects the sequence of migrations by which people spread throughout the world. Beyond its use in human evolutionary genetics, worldwide variation in genetic diversity sometimes can interact with social processes to produce differences among populations in their relationship to modern societal problems. We review the consequences of genetic diversity differences in the settings of familial identification in forensic genetic testing, match probabilities in bone marrow transplantation, and representation in genome-wide association studies of disease. In each of these three cases, the contribution of genetic diversity to social differences follows from population-genetic principles. For a fourth setting that is not similarly grounded, we reanalyze with expanded genetic data a report that genetic diversity differences influence global patterns of human economic development, finding no support for the claim. The four examples describe a limit to the importance of genetic diversity for explaining societal differences while illustrating a distinction that certain biologically based scenarios do require consideration of genetic diversity for solving problems to which populations have been differentially predisposed by the unique history of human migrations. PMID:26354973

  13. BatAlign: an incremental method for accurate alignment of sequencing reads

    PubMed Central

    Lim, Jing-Quan; Tennakoon, Chandana; Guan, Peiyong; Sung, Wing-Kin

    2015-01-01

    Structural variations (SVs) play a crucial role in genetic diversity. However, the alignments of reads near/across SVs are made inaccurate by the presence of polymorphisms. BatAlign is an algorithm that integrated two strategies called ‘Reverse-Alignment’ and ‘Deep-Scan’ to improve the accuracy of read-alignment. In our experiments, BatAlign was able to obtain the highest F-measures in read-alignments on mismatch-aberrant, indel-aberrant, concordantly/discordantly paired and SV-spanning data sets. On real data, the alignments of BatAlign were able to recover 4.3% more PCR-validated SVs with 73.3% less callings. These suggest BatAlign to be effective in detecting SVs and other polymorphic-variants accurately using high-throughput data. BatAlign is publicly available at https://goo.gl/a6phxB. PMID:26170239

  14. Societal and Economic Impact of Anterior Cruciate Ligament Tears

    PubMed Central

    Mather, Richard C.; Koenig, Lane; Kocher, Mininder S.; Dall, Timothy M.; Gallo, Paul; Scott, Daniel J.; Bach, Bernard R.; Spindler, Kurt P.

    2013-01-01

    Background: An anterior cruciate ligament (ACL) tear is a common knee injury, particularly among young and active individuals. Little is known, however, about the societal impacts of ACL tears, which could be large given the typical patient age and increased lifetime risk of knee osteoarthritis. This study evaluates the cost-effectiveness of ACL reconstruction compared with structured rehabilitation only. Methods: A cost-utility analysis of ACL reconstruction compared with structured rehabilitation only was conducted with use of a Markov decision model over two time horizons: the short to intermediate term (six years), on the basis of Level-I evidence derived from the KANON Study and the Multicenter Orthopaedic Outcomes Network (MOON) database; and the lifetime, on the basis of a comprehensive literature review. Utilities were assessed with use of the SF-6D. Costs (in 2012 U.S. dollars) were estimated from the societal perspective and included the effects of the ACL tear on work status, earnings, and disability. Effectiveness was expressed as quality-adjusted life years (QALYs) gained. Results: In the short to intermediate term, ACL reconstruction was both less costly (a cost reduction of $4503) and more effective (a QALY gain of 0.18) compared with rehabilitation. In the long term, the mean lifetime cost to society for a typical patient undergoing ACL reconstruction was $38,121 compared with $88,538 for rehabilitation. ACL reconstruction resulted in a mean incremental cost savings of $50,417 while providing an incremental QALY gain of 0.72 compared with rehabilitation. Effectiveness gains were driven by the higher probability of an unstable knee and associated lower utility in the rehabilitation group. Results were most sensitive to the rate of knee instability after initial rehabilitation. Conclusions: ACL reconstruction is the preferred cost-effective treatment strategy for ACL tears and yields reduced societal costs relative to rehabilitation once indirect cost factors, such as work status and earnings, are considered. The cost of an ACL tear over the lifetime of a patient is substantial, and resources should be directed to developing innovations for injury prevention and for altering the natural history of an ACL injury. PMID:24088967

  15. The Influence Factors and Mechanism of Societal Risk Perception

    NASA Astrophysics Data System (ADS)

    Zheng, Rui; Shi, Kan; Li, Shu

    Risk perception is one of important subjects in management psychology and cognitive psychology. It is of great value in the theory and practice to investigate the societal hazards that the public cares a lot especially in Socio-economic transition period. A survey including 30 hazards and 6 risk attributes was designed and distributed to about 2, 485 residents of 8 districts, Beijing. The major findings are listed as following: Firstly, a scale of societal risk perception was designed and 2 factors were identified (Dread Risk & Unknown Risk). Secondly, structural equation model was used to analyze the influence factors and mechanism of societal risk perception. Risk preference, government support and social justice could influence societal risk perception directly. Government support fully moderated the relationship between government trust and societal risk perception. Societal risk perception influenced life satisfaction, public policy preferences and social development belief.

  16. Aligned nanotubes.

    PubMed

    Dai, Liming; Patil, Ajeeta; Gong, Xiaoyi; Guo, Zhixin; Liu, Luqi; Liu, Yong; Zhu, Daoben

    2003-11-14

    Since the discovery of carbon nanotubes by lijima in 1991, various carbon nanotubes with either a single- or multilayered graphene cylinder(s) have been produced, along with their noncarbon counterparts (for example, inorganic and polymer nanotubes). These nanostructured materials often possess size-dependent properties and show new phenomena related to the nanosize confinement of the charge carriers inside, which leads to the possibility of developing new materials with useful properties and advanced devices with desirable features for a wide range of applications. In particular, carbon nanotubes have been shown to exhibit superior properties attractive for various potential applications, ranging from their use as novel electron emitters in flat-panel displays to electrodes in electrochemical sensors. For many of the applications, it is highly desirable to have aligned/patterned forms of carbon nanotubes so that their structure/property can be easily assessed and so that they can be effectively incorporated into devices. In this Review, we present an overview on the development of aligned and micropatterned nanotubes, with an emphasis on carbon nanotubes. PMID:14652993

  17. Extreme space weather studies: Addressing societal needs

    NASA Astrophysics Data System (ADS)

    Ngwira, C. M.

    2014-12-01

    Extreme space weather events can adversely impact the operations of critical modern-day technological infrastructure such as high-voltage electric power transmission grids. Understanding of coupled magnetosphere-ionosphere dynamics under extreme solar wind driving conditions is still a major challenge mainly because of a lack of data during such time intervals. This presentation will highlight some of the past and on-going investigations on extreme space weather events, and how these investigations are used to address societal needs. Particularly, I will describe how first principles physics-based 3-D global MHD models are playing a major role in advancing our knowledge on extreme geomagnetically induced currents. These MHD models represent a very important component of attempts to understand the response of the magnetosphere-ionosphere system to varying solar wind conditions.

  18. Applications and societal benefits of plastics.

    PubMed

    Andrady, Anthony L; Neal, Mike A

    2009-07-27

    This article explains the history, from 1600 BC to 2008, of materials that are today termed 'plastics'. It includes production volumes and current consumption patterns of five main commodity plastics: polypropylene, polyethylene, polyvinyl chloride, polystyrene and polyethylene terephthalate. The use of additives to modify the properties of these plastics and any associated safety, in use, issues for the resulting polymeric materials are described. A comparison is made with the thermal and barrier properties of other materials to demonstrate the versatility of plastics. Societal benefits for health, safety, energy saving and material conservation are described, and the particular advantages of plastics in society are outlined. Concerns relating to littering and trends in recycling of plastics are also described. Finally, we give predictions for some of the potential applications of plastic over the next 20 years. PMID:19528050

  19. Applications and societal benefits of plastics

    PubMed Central

    Andrady, Anthony L.; Neal, Mike A.

    2009-01-01

    This article explains the history, from 1600 BC to 2008, of materials that are today termed ‘plastics’. It includes production volumes and current consumption patterns of five main commodity plastics: polypropylene, polyethylene, polyvinyl chloride, polystyrene and polyethylene terephthalate. The use of additives to modify the properties of these plastics and any associated safety, in use, issues for the resulting polymeric materials are described. A comparison is made with the thermal and barrier properties of other materials to demonstrate the versatility of plastics. Societal benefits for health, safety, energy saving and material conservation are described, and the particular advantages of plastics in society are outlined. Concerns relating to littering and trends in recycling of plastics are also described. Finally, we give predictions for some of the potential applications of plastic over the next 20 years. PMID:19528050

  20. IUS prerelease alignment

    NASA Technical Reports Server (NTRS)

    Evans, F. A.

    1978-01-01

    Space shuttle orbiter/IUS alignment transfer was evaluated. Although the orbiter alignment accuracy was originally believed to be the major contributor to the overall alignment transfer error, it was shown that orbiter alignment accuracy is not a factor affecting IUS alignment accuracy, if certain procedures are followed. Results are reported of alignment transfer accuracy analysis.

  1. Societal Benefits of Ocean Altimetry Data

    NASA Technical Reports Server (NTRS)

    Srinivasen, Margaret; Leben, Robert

    2004-01-01

    The NASA/CNES Jason satellite, follow-on to the highly successful TOPEX/Poseidon mission, continues to provide oceanographers and marine operators across the globe with a continuous twelve-year, high quality stream of sea surface height data. The mission is expected to extend through 2007, when the NASA/NOAA/CNES follow-on mission, OSTM, will be launched with the wide-swath ocean altimeter on board. This unprecedented resource of valuable ocean data is being used to map sea surface height, geostrophic velocity, significant wave height, and wind speed over the global oceans. Altimeter data products are currently used by hundreds of researchers and operational users to monitor ocean circulation and improve our understanding of the role of the oceans in climate and weather. Ocean altimeter data has many societal benefits and has proven invaluable in many practical applications including; a) Ocean forecasting systems; b) Climate research and forecasting; c) Ship routing; d) Fisheries management; e) Marine mammal habitat monitoring; f) Hurricane forecasting and tracking; g) Debris tracking; and h) Precision marine operations such as cable-laying and oil production. The data has been cited in nearly 2,000 research and popular articles since the launch of TOPEX/Poseidon in 1992, and almost 200 scientific users receive the global coverage altimeter data on a monthly basis. In addition to the scientific and operational uses of the data, the educational community has seized the unique concepts highlighted by these altimeter missions as a resource for teaching ocean science to students from grade school through college. This presentation will highlight societal benefits of ocean altimetry data in the areas of climate studies, marine operations, marine research, and non-ocean investigations.

  2. Critical Zone Science and Global Societal Challenges

    NASA Astrophysics Data System (ADS)

    Goldhaber, M. B.; Banwart, S. A.

    2014-12-01

    Earth's Critical Zone (CZ) is the thin outer veneer of our planet from the top of the tree canopy to the bottom of our drinking water aquifers that supports almost all human activity. Despite its fundamental importance to terrestrial life, understanding of the operation of the coupled geologic, hydrologic, topographic, and biotic CZ processes across time and space is far from complete. These interactions are complex and they establish a mechanistic 'chain of impact' that transmits the effects of environmental change throughout the CZ. Characterization of these processes is made more urgent by the fact that globally, the CZ is experiencing ever-increasing pressure from growth in human population and wealth. Within the next four decades, demand for food and fuel is expected to double along with a more than 50% increase in demand for clean water. Understanding, predicting and managing intensification of land use and associated economic services, while mitigating and adapting to rapid climate change, is now one of the most pressing societal challenges of the 21st century. In this talk we summarize the profound global societal impacts to the Earth's near surface arising from exponential human population growth, increasing affluence, and technological advance, to provide context for discussions on constructing an array of CZ observatories to both characterize fundamental critical zone processes and forecast the effects of planetary change. We will suggest goals and options relevant to planning for a future international array of CZ observatories and a research agenda that matches the urgency of the projected resource demands and environmental pressures of the coming four decades.

  3. Reducing societal vulnerability to drought: A methodology

    SciTech Connect

    Wilhite, D.A.

    1995-12-31

    Given worldwide experience with drought during the past several decades and the magnitude of associated impacts, it is apparent that vulnerability to extended periods of water shortage is escalating. Developing a national or provincial drought policy and preparedness plan is a complicated but essential first step toward reducing societal vulnerability. Until recently, nations had devoted little effort to drought preparedness, preferring instead the reactive or crisis management approach. Presently, an increasing number of nations are pursuing a more proactive approach that emphasizes the principles of risk management and sustainable development. Because of the multitude of impacts associated with drought and the numerous governmental agencies that have responsibility for some aspect of monitoring, assessment, mitigation, and planning, developing a policy and plan must be an integrated process within and between levels of government. This paper outlines a generic process that can be adopted by governments that desire to develop a more comprehensive and long-term approach to drought management and planning. Countries and states or provincial authorities that have adopted this approach is presented as case studies. This process is timely, given the declaration of the 1990s as the International Decade for Natural Disaster Reduction and the recent International Convention to Combat Desertification and Drought (June, 1994), an offshoot of deliberations at the United Nations Conference on Environment and Development.

  4. Computer ethics education: Impact from societal norms

    SciTech Connect

    White, G.B.

    1994-12-31

    Discussions have occurred on the best way to implement the horizontal and vertical integration of education on the social, ethical and professional issues relating to computer science. These discussions have not only included debates on the subject matter and what manner to approach it (i.e. integrated among all computer science courses taught, as a separate required course, or a combination of both), but have also involved debates over who is best qualified to address the subject. What has seldom been addressed, however, is how societal impressions of what is ethical have impacted both those who develop software and those who use it. In light of the experience of such institutions as the U.S. Air Force Academy which recently instituted a program called the Center for Character Development (due to a perceived erosion of the core values of its recruits), should academia and industry expect more from computer scientists than from the population as a whole? It is the integration of ethics courses in the computer science curriculum in light of a general erosion of ethical values in society as a whole that is addressed in this paper.

  5. Satellite Power System (SPS) societal assessment

    SciTech Connect

    Not Available

    1980-12-01

    Construction and operation of a 60-unit (300 GW) domestic SPS over the period 2000 to 2030 would stress many segments of US society. A significant commitment of resources (land, energy, materials) would be required, and a substantial proportion of them would have to be committed prior to the production of any SPS electricity. Estimated resource demands, however, seem to be within US capabilities. Modifications will be required of institutions called upon to deal with SPS. These include financial, managerial and regulatory entities and, most particularly, the utility industry. Again, the required changes, while certainly profound, seem to be well within the realm of possibility. Enhanced cooperation in international affairs will be necessary to accommodate development and operation of the SPS. To remove its potential as a military threat and to reduce its vulnerability, either the SPS itself must become an international enterprise, or it must be subject to unrestricted international inspection. How either of these objectives could, in fact, be achieved, or which is preferable, remains unclear. Forty-four concerns about the SPS were identified via a public outreach experiment involving 9000 individuals from three special interest organizations. The concerns focused on environmental impacts (particularly the effects of microwave radiation) and the centralizing tendency of the SPS on society. The interim results of the public outreach experiment influenced the scope and direction of the CDEP; the final results will be instrumental in defining further societal assessment efforts.

  6. Economics and societal impacts of tornadoes

    NASA Astrophysics Data System (ADS)

    Bluestein, Howard B.

    2011-08-01

    During the spring of 2011, there were a record number of unusually strong and devastating tornadoes in the United States, which killed more than 500 people, the most in the country since 1953. Tornadoes are responsible for more than $1 billion annually (adjusted to 2007 U.S. dollars) in property damage and for disrupting thousands of lives and businesses. The most notable tornado this past spring devastated Joplin, Mo.; tornadoes also struck such diverse locations as Springfield, Mass.; Tuscaloosa, Ala.; Raleigh, N. C.; communities near Oklahoma City, Okla.; Minneapolis, Minn.; central and east Texas; Philadelphia, Pa.; and St. Louis, Mo. It is therefore timely to assess the economic and societal impacts of tornadoes. In this book the authors use various statistical techniques to evaluate the cost of tornadoes to society. They begin by reviewing the methodologies of formulating a tornado climatology across diverse regions according to tornado intensity, deaths, injuries, and property damage, and they then provide a history of the U.S. National Weather Service's (NWS) public warning efforts, describe tornado shelters and how the public responds to warnings, and suggest ways to reduce tornado risk.

  7. Convenient meat and meat products. Societal and technological issues.

    PubMed

    Leroy, Frédéric; Degreef, Filip

    2015-11-01

    In past and contemporary foodscapes, meat and meat products have not only been following convenience trends, they have been at the heart of them. Historically, the first substantial demands for meat convenience must have been for the outsourcing of hunting or domestication, as well as slaughtering activities. In its turn, this prompted concerns for shelf-life stabilisation and the development of preservation strategies, such as meat fermentation. Demands for ease of preparation and consumption can be traced back to Antiquity but have gained in importance over the centuries, especially with the emergence of novel socio-cultural expectations and (perceived) time scarcity. Amongst other trends, this has led to the creation of ready meals and meat snacks and the expansion of urban fast food cultures. Additionally, contemporary requirements focus on the reduction of mental investments, via the "convenient" concealment of slaughtering, the optimisation of nutritional qualities, and the instant incorporation of more intangible matters, such as variety, hedonistic qualities, reassurance, and identity. An overview is given of the technological issues related to the creation of meat convenience, in its broadest sense, along with their societal implications. PMID:25656303

  8. DNA Align Editor: DNA Alignment Editor Tool

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The SNPAlignEditor is a DNA sequence alignment editor that runs on Windows platforms. The purpose of the program is to provide an intuitive, user-friendly tool for manual editing of multiple sequence alignments by providing functions for input, editing, and output of nucleotide sequence alignments....

  9. Human initiated cascading failures in societal infrastructures.

    PubMed

    Barrett, Chris; Channakeshava, Karthik; Huang, Fei; Kim, Junwhan; Marathe, Achla; Marathe, Madhav V; Pei, Guanhong; Saha, Sudip; Subbiah, Balaaji S P; Vullikanti, Anil Kumar S

    2012-01-01

    In this paper, we conduct a systematic study of human-initiated cascading failures in three critical inter-dependent societal infrastructures due to behavioral adaptations in response to a crisis. We focus on three closely coupled socio-technical networks here: (i) cellular and mesh networks, (ii) transportation networks and (iii) mobile call networks. In crises, changes in individual behaviors lead to altered travel, activity and calling patterns, which influence the transport network and the loads on wireless networks. The interaction between these systems and their co-evolution poses significant technical challenges for representing and reasoning about these systems. In contrast to system dynamics models for studying these interacting infrastructures, we develop interaction-based models in which individuals and infrastructure elements are represented in detail and are placed in a common geographic coordinate system. Using the detailed representation, we study the impact of a chemical plume that has been released in a densely populated urban region. Authorities order evacuation of the affected area, and this leads to individual behavioral adaptation wherein individuals drop their scheduled activities and drive to home or pre-specified evacuation shelters as appropriate. They also revise their calling behavior to communicate and coordinate among family members. These two behavioral adaptations cause flash-congestion in the urban transport network and the wireless network. The problem is exacerbated with a few, already occurring, road closures. We analyze how extended periods of unanticipated road congestion can result in failure of infrastructures, starting with the servicing base stations in the congested area. A sensitivity analysis on the compliance rate of evacuees shows non-intuitive effect on the spatial distribution of people and on the loading of the base stations. For example, an evacuation compliance rate of 70% results in higher number of overloaded base stations than the evacuation compliance rate of 90%. PMID:23118847

  10. Utilizing Earth Observations for Societal Issues

    NASA Technical Reports Server (NTRS)

    Habib, Shahid

    2010-01-01

    Over the last four decades a tremendous progress has been made in the Earth science space-based remote sensing observations, technologies and algorithms. Such advancements have improved the predictability by providing lead-time and accuracy of forecast in weather, climate, natural hazards, and natural resources. It has further reduced or bounded the overall uncertainties by partially improving our understanding of planet Earth as an integrated system that is governed by non-linear and chaotic behavior. Many countries such as the US, European Community, Japan, China, Russia, India has and others have invested billions of dollars in developing and launching space-based assets in the low earth (LEO) and geostationary (GEO) orbits. However, the wealth of this scientific knowledge that has potential of extracting monumental socio-economic benefits from such large investments have been slow in reaching the public and decision makers. For instance, there are a number of areas such as water resources and availability, energy forecasting, aviation safety, agricultural competitiveness, disaster management, air quality and public health, which can directly take advantage. Nevertheless, we all live in a global economy that depends on access to the best available Earth Science information for all inhabitants of this planet. This presentation discusses a process to transition Earth science data and products for societal needs including NASA's experience in achieving such objectives. It is important to mention that there are many challenges and issues that pertain to a number of areas such as: (1) difficulties in making a speedy transition of data and information from observations and models to relevant Decision Support Systems (DSS) or tools, (2) data and models inter-operability issues, (3) limitations of spatial, spectral and temporal resolution, (4) communication limitations as dictated by the availability of image processing and data compression techniques. Additionally, the most critical element amongst all is the organizational and management boundaries that must be resolved at local, state, national and international levels to implement and realize free flow of such vital information.

  11. Human Initiated Cascading Failures in Societal Infrastructures

    PubMed Central

    Barrett, Chris; Channakeshava, Karthik; Huang, Fei; Kim, Junwhan; Marathe, Achla; Marathe, Madhav V.; Pei, Guanhong; Saha, Sudip; Subbiah, Balaaji S. P.; Vullikanti, Anil Kumar S.

    2012-01-01

    In this paper, we conduct a systematic study of human-initiated cascading failures in three critical inter-dependent societal infrastructures due to behavioral adaptations in response to a crisis. We focus on three closely coupled socio-technical networks here: (i) cellular and mesh networks, (ii) transportation networks and (iii) mobile call networks. In crises, changes in individual behaviors lead to altered travel, activity and calling patterns, which influence the transport network and the loads on wireless networks. The interaction between these systems and their co-evolution poses significant technical challenges for representing and reasoning about these systems. In contrast to system dynamics models for studying these interacting infrastructures, we develop interaction-based models in which individuals and infrastructure elements are represented in detail and are placed in a common geographic coordinate system. Using the detailed representation, we study the impact of a chemical plume that has been released in a densely populated urban region. Authorities order evacuation of the affected area, and this leads to individual behavioral adaptation wherein individuals drop their scheduled activities and drive to home or pre-specified evacuation shelters as appropriate. They also revise their calling behavior to communicate and coordinate among family members. These two behavioral adaptations cause flash-congestion in the urban transport network and the wireless network. The problem is exacerbated with a few, already occurring, road closures. We analyze how extended periods of unanticipated road congestion can result in failure of infrastructures, starting with the servicing base stations in the congested area. A sensitivity analysis on the compliance rate of evacuees shows non-intuitive effect on the spatial distribution of people and on the loading of the base stations. For example, an evacuation compliance rate of 70% results in higher number of overloaded base stations than the evacuation compliance rate of 90%. PMID:23118847

  12. Physical, Ecological, and Societal Indicators for the National Climate Assessment

    NASA Technical Reports Server (NTRS)

    Kenney, Melissa A.; Chen, Robert; Baptista, Sandra R.; Quattrochi, Dale; O'Brien, Sheila

    2011-01-01

    The National Climate Assessment (NCA) is being conducted under the auspices of the U.S. Global Change Research Program (USGCRP), pursuant to the Global Change Research Act of 1990, Section 106, which requires a report to Congress every 4 years. The current NCA (http://globalchange.gov/what-we-do/assessment/) differs in multiple ways from previous U.S. climate assessment efforts, being: (1) more focused on supporting the Nation s activities in adaptation and mitigation and on evaluating the current state of scientific knowledge relative to climate impacts and trends; (2) a long-term, consistent process for evaluation of climate risks and opportunities and providing information to support decision-making processes within regions and sectors; and (3) establishing a permanent assessment capacity both inside and outside of the federal government. As a part of ongoing, long-term assessment activities, the NCA intends to develop an integrated strategic framework and deploy climate-relevant physical, ecological, and societal indicators. The NCA indicators framework is underdevelopment by the NCA Development and Advisory Committee Indicators Working Group and are envisioned as a relatively small number of policy-relevant integrated indicators designed to provide a consistent, objective, and transparent overview of major variations in climate impacts, vulnerabilities, adaptation, and mitigation activities across sectors, regions, and timeframes. The potential questions that could be addressed by these indicators include: How do we know that there is a changing climate and how is it expected to change in the future? Are important climate impacts and opportunities occurring or predicted to occur in the future? Are we adapting successfully? What are the vulnerabilities and resiliencies given a changing climate? Are we preparing adequately for extreme events? It is not expected that the NCA societal indicators would be linked directly to a single decision or portfolio of decisions, but subsets of indicators, or the data supporting the indicator, might be used to inform decision-making processes such as the development and implementation of climate adaptation strategies in a particular sector or region.

  13. Risk management: Role of societal factors in major industrial accidents

    SciTech Connect

    Hovden, J.; Rausand, M.; Sergeev, G.

    1995-12-31

    The paper discusses factors influencing the occurrence of major accidents in complex technological systems. Societal factors are identified as most significant in this context. Important types of societal factors are pin-pointed and discussed. The safety situation in the former Soviet Union and in today`s Russian is described. The calamities at Chernobyl, Three Mile Island, and partly also Bhopal are discussed, and the role of societal factors identified. A main point of view is that it is not surprising that these catastrophes happened in the then existing conditions. What is surprising is that they did not happen earlier!

  14. Teacher Perception of the Alignment of Enhancing Missouri's Instructional Networked Teaching Strategies (eMINTS) with the National Staff Development Council (NSDC) Standards

    ERIC Educational Resources Information Center

    Stanfill, Diana L.

    2010-01-01

    This study used the National Staff Development Council (NSDC) standards for staff development as a framework for measuring specific aspects of the enhancing Missouri's Instructional Networked Teaching Strategies (eMINTS) educational technology professional development program, as perceived by eMINTS teachers. The Technology Integration Cycle…

  15. Teacher Perception of the Alignment of Enhancing Missouri's Instructional Networked Teaching Strategies (eMINTS) with the National Staff Development Council (NSDC) Standards

    ERIC Educational Resources Information Center

    Stanfill, Diana L.

    2010-01-01

    This study used the National Staff Development Council (NSDC) standards for staff development as a framework for measuring specific aspects of the enhancing Missouri's Instructional Networked Teaching Strategies (eMINTS) educational technology professional development program, as perceived by eMINTS teachers. The Technology Integration Cycle…

  16. The next decade of vaccines: societal and scientific challenges.

    PubMed

    Moxon, E Richard; Siegrist, Claire-Anne

    2011-07-23

    Vaccines against microbial diseases have improved the health of millions of people. In the next decade and beyond, many conceptual and technological scientific advances offer extraordinary opportunities to expand the portfolio of immunisations against viral and bacterial diseases and to pioneer the first vaccines against human parasitic and fungal diseases. Scientists in the public and private sectors are motivated as never before to bring about these innovations in immunisation. Many societal factors threaten to compromise realisation of the public health gains that immunisation can achieve in the next decade and beyond--understanding these factors is imperative. Vaccines are typically given to healthy individuals and safety issues loom high on the list of public concerns. The public needs to regain confidence in immunisation and trust the organisations responsible for the research, development, and implementation of vaccines. In the past, by use of a judicious amalgam of knowledge and empiricism, successful vaccines were largely developed by microbiologists who identified antigens that induced immune responses to conserved pathogen components. In the future, vaccines need to be developed against deadly diseases for which this strategy is often not feasible because of the extensive antigenic variability of relevant pathogens. High microbial diversity means that immunity after natural infection is often ineffective for prevention of disease on subsequent exposure, for example in HIV infection and malaria. Additionally, vaccines need to be generated to protect the people who are most vulnerable because of age or underlying diseases. Thus, in the future, a much deeper understanding of the immunological challenges--including the diversifying role of host genetics and environmental factors, leading perhaps to more personalised approaches-will be the touchstone for rational design and development of adjuvants that result in novel safe and effective vaccines. PMID:21664685

  17. Social connectedness, conformity, and internalization of societal standards of attractiveness.

    PubMed

    Vartanian, Lenny R; Hopkinson, Meghan M

    2010-01-01

    Internalization of societal standards of attractiveness is known to play a role in the development of body dissatisfaction and disordered eating, and researchers are now working toward identifying factors that influence the internalization of those societal standards. The present study examined to what extent social connectedness and conformity were related to internalization. Female college students (n=300) completed measures of social connectedness, conformity, and internalization, as well as measures of body image concerns, dietary restraint, and bulimic symptoms. Path analysis showed that social connectedness was negatively related to conformity, and that conformity was positively related to internalization. Consistent with past research, internalization predicted body image concerns and dietary restraint, which in turn predicted bulimic symptoms. Conformity appears to be a risk factor for the internalization of societal standards of attractiveness, and could be targeted in efforts to reduce internalization, negative body image, and disordered eating. PMID:19910270

  18. Societal interventions to prevent child abuse and neglect.

    PubMed

    Hay, T; Jones, L

    1994-01-01

    A framework for understanding child maltreatment in terms of complex and interacting factors from the individual to the societal level can aid in conceptualizing and implementing prevention efforts. Research on interventions at the societal level can guide a broad range of activities, increasing their effectiveness and viability. Fundamental approaches include evaluation of specific interventions and systems-level research on implementation and development of best practice in prevention activities for different portions of society. Research can indicate the roles that each individual, agency, organization, community, and level of government can play. The U.N. Convention on the Rights of the Child provides a useful framework for societal level change to improve the welfare of children and families. PMID:7924560

  19. Societal influences on health and life-styles.

    PubMed

    Ulmer, D D

    1984-12-01

    Strong sociocultural forces affect individual attitudes toward health and choice of life-style. Economic deprivation fosters negative health behaviors. Positive health habits are reinforced by discrete societal groups. The news media, particularly television, disseminate much useful health information, though the overall educational value is diminished by the content of commercial messages and programming. The automobile is a major societal influence, but neither individual drivers nor the car manufacturers give enough priority to highway safety, leaving that role to governmental regulation. American industry is becoming a positive influence in the encouragement of good health habits, and fashion is lately an important ally in personal health maintenance. PMID:6523860

  20. Societal Influences on Health and Life-styles

    PubMed Central

    Ulmer, David D.

    1984-01-01

    Strong sociocultural forces affect individual attitudes toward health and choice of life-style. Economic deprivation fosters negative health behaviors. Positive health habits are reinforced by discrete societal groups. The news media, particularly television, disseminate much useful health information, though the overall educational value is diminished by the content of commercial messages and programming. The automobile is a major societal influence, but neither individual drivers nor the car manufacturers give enough priority to highway safety, leaving that role to governmental regulation. American industry is becoming a positive influence in the encouragement of good health habits, and fashion is lately an important ally in personal health maintenance. PMID:6523860

  1. Fast Statistical Alignment

    PubMed Central

    Bradley, Robert K.; Roberts, Adam; Smoot, Michael; Juvekar, Sudeep; Do, Jaeyoung; Dewey, Colin; Holmes, Ian; Pachter, Lior

    2009-01-01

    We describe a new program for the alignment of multiple biological sequences that is both statistically motivated and fast enough for problem sizes that arise in practice. Our Fast Statistical Alignment program is based on pair hidden Markov models which approximate an insertion/deletion process on a tree and uses a sequence annealing algorithm to combine the posterior probabilities estimated from these models into a multiple alignment. FSA uses its explicit statistical model to produce multiple alignments which are accompanied by estimates of the alignment accuracy and uncertainty for every column and character of the alignment—previously available only with alignment programs which use computationally-expensive Markov Chain Monte Carlo approaches—yet can align thousands of long sequences. Moreover, FSA utilizes an unsupervised query-specific learning procedure for parameter estimation which leads to improved accuracy on benchmark reference alignments in comparison to existing programs. The centroid alignment approach taken by FSA, in combination with its learning procedure, drastically reduces the amount of false-positive alignment on biological data in comparison to that given by other methods. The FSA program and a companion visualization tool for exploring uncertainty in alignments can be used via a web interface at http://orangutan.math.berkeley.edu/fsa/, and the source code is available at http://fsa.sourceforge.net/. PMID:19478997

  2. Research and Evaluations of the Health Aspects of Disasters, Part IV: Framework for Societal Structures: the Societal Systems.

    PubMed

    Birnbaum, Marvin L; Daily, Elaine K; O'Rourke, Ann P

    2015-12-01

    For the purposes of research and/or evaluation, a community/society is organized into 13 Societal Systems under the umbrella of an overall Coordination and Control System. This organization facilitates descriptions of a community/society or a component of a community for assessment at any designated time across the Temporal Phases of a disaster. Such assessments provide a picture of the functional status of one or more Systems that comprise a community. Since no system operates in isolation from the other systems, information of the concomitant status of several Societal Systems is crucial to gaining a complete understanding of compromised functions, as well as the effects and side effects of any intervention directed at restoring the functional state of the affected community or risk-reduction interventions of a community-at-risk. The 13 Societal Systems include: (1) Public Health; (2) Medical Care; (3) Water and Sanitation; (4) Shelter and Clothing; (5) Food and Nutrition; (6) Energy Supply; (7) Public Works and Engineering; (8) Social Structures; (9) Logistics and Transportation; (10) Security; (11) Communications; (12) Economy; and (13) Education. Many functions and sub-functions of the Systems overlap, or share some common sub-functions with other systems. For the purposes of research/evaluation, it is necessary to assign functions and sub-functions to only one of the Societal Systems. Birnbaum ML , Daily EK , O'Rourke AP . Research and evaluations of the health aspects of disasters, part IV: framework for societal structures: the Societal Systems. Prehosp Disaster Med. 2015;30(6):633-647. PMID:26568075

  3. Biodiesel and Integrated STEM: Vertical Alignment of High School Biology/Biochemistry and Chemistry

    ERIC Educational Resources Information Center

    Burrows, Andrea C.; Breiner, Jonathan M.; Keiner, Jennifer; Behm, Chris

    2014-01-01

    This article explores the vertical alignment of two high school classes, biology and chemistry, around the core concept of biodiesel fuel production. High school teachers and university faculty members investigated biodiesel as it relates to societal impact through a National Science Foundation Research Experience for Teachers. Using an action…

  4. Biodiesel and Integrated STEM: Vertical Alignment of High School Biology/Biochemistry and Chemistry

    ERIC Educational Resources Information Center

    Burrows, Andrea C.; Breiner, Jonathan M.; Keiner, Jennifer; Behm, Chris

    2014-01-01

    This article explores the vertical alignment of two high school classes, biology and chemistry, around the core concept of biodiesel fuel production. High school teachers and university faculty members investigated biodiesel as it relates to societal impact through a National Science Foundation Research Experience for Teachers. Using an action…

  5. Girder Alignment Plan

    SciTech Connect

    Wolf, Zackary; Ruland, Robert; LeCocq, Catherine; Lundahl, Eric; Levashov, Yurii; Reese, Ed; Rago, Carl; Poling, Ben; Schafer, Donald; Nuhn, Heinz-Dieter; Wienands, Uli; ,

    2010-11-18

    The girders for the LCLS undulator system contain components which must be aligned with high accuracy relative to each other. The alignment is one of the last steps before the girders go into the tunnel, so the alignment must be done efficiently, on a tight schedule. This note documents the alignment plan which includes efficiency and high accuracy. The motivation for girder alignment involves the following considerations. Using beam based alignment, the girder position will be adjusted until the beam goes through the center of the quadrupole and beam finder wire. For the machine to work properly, the undulator axis must be on this line and the center of the undulator beam pipe must be on this line. The physics reasons for the undulator axis and undulator beam pipe axis to be centered on the beam are different, but the alignment tolerance for both are similar. In addition, the beam position monitor must be centered on the beam to preserve its calibration. Thus, the undulator, undulator beam pipe, quadrupole, beam finder wire, and beam position monitor axes must all be aligned to a common line. All relative alignments are equally important, not just, for example, between quadrupole and undulator. We begin by making the common axis the nominal beam axis in the girder coordinate system. All components will be initially aligned to this axis. A more accurate alignment will then position the components relative to each other, without incorporating the girder itself.

  6. MP-Align: alignment of metabolic pathways

    PubMed Central

    2014-01-01

    Background Comparing the metabolic pathways of different species is useful for understanding metabolic functions and can help in studying diseases and engineering drugs. Several comparison techniques for metabolic pathways have been introduced in the literature as a first attempt in this direction. The approaches are based on some simplified representation of metabolic pathways and on a related definition of a similarity score (or distance measure) between two pathways. More recent comparative research focuses on alignment techniques that can identify similar parts between pathways. Results We propose a methodology for the pairwise comparison and alignment of metabolic pathways that aims at providing the largest conserved substructure of the pathways under consideration. The proposed methodology has been implemented in a tool called MP-Align, which has been used to perform several validation tests. The results showed that our similarity score makes it possible to discriminate between different domains and to reconstruct a meaningful phylogeny from metabolic data. The results further demonstrate that our alignment algorithm correctly identifies subpathways sharing a common biological function. Conclusion The results of the validation tests performed with MP-Align are encouraging. A comparison with another proposal in the literature showed that our alignment algorithm is particularly well-suited to finding the largest conserved subpathway of the pathways under examination. PMID:24886436

  7. Technology Alignment and Portfolio Prioritization (TAPP)

    NASA Technical Reports Server (NTRS)

    Funaro, Gregory V.; Alexander, Reginald A.

    2015-01-01

    Technology Alignment and Portfolio Prioritization (TAPP) is a method being developed by the Advanced Concepts Office, at NASA Marshall Space Flight Center. The TAPP method expands on current technology assessment methods by incorporating the technological structure underlying technology development, e.g., organizational structures and resources, institutional policy and strategy, and the factors that motivate technological change. This paper discusses the methods ACO is currently developing to better perform technology assessments while taking into consideration Strategic Alignment, Technology Forecasting, and Long Term Planning.

  8. Physical, Ecological, and Societal Indicators for the National Climate Assessment

    NASA Astrophysics Data System (ADS)

    O'Brien, S.; Kenney, M.; Chen, R. S.; Baptista, S. R.; Quattrochi, D. A.

    2011-12-01

    The National Climate Assessment (NCA) is being conducted under the auspices of the U.S. Global Change Research Program (USGCRP), pursuant to the Global Change Research Act of 1990, Section 106, which requires a report to Congress every 4 years. The current NCA (http://globalchange.gov/what-we-do/assessment/) differs in multiple ways from previous U.S. climate assessment efforts, being: (1) more focused on supporting the Nation's activities in adaptation and mitigation and on evaluating the current state of scientific knowledge relative to climate impacts and trends; (2) a long-term, consistent process for evaluation of climate risks and opportunities and providing information to support decision-making processes within regions and sectors; and (3) establishing a permanent assessment capacity both inside and outside of the federal government. As a part of ongoing, long-term assessment activities, the NCA intends to develop an integrated strategic framework and deploy climate-relevant physical, ecological, and societal indicators. The NCA indicators framework is underdevelopment by the NCA Development and Advisory Committee Indicators Working Group and are envisioned as a relatively small number of policy-relevant integrated indicators designed to provide a consistent, objective, and transparent overview of major variations in climate impacts, vulnerabilities, adaptation, and mitigation activities across sectors, regions, and timeframes. The potential questions that could be addressed by these indicators include: -How do we know that there is a changing climate and how is it expected to change in the future? -Are important climate impacts and opportunities occurring or predicted to occur in the future? -Are we adapting successfully? -What are the vulnerabilities and resiliencies given a changing climate? -Are we preparing adequately for extreme events? It is not expected that the NCA indicators would be linked directly to a single decision or portfolio of decisions, but subsets of indicators, or the data supporting the indicator, might be used to inform decision-making processes such as the development and implementation of climate adaptation strategies in a particular sector or region.

  9. Taking a Societal Sector Perspective on Youth Learning and Development

    ERIC Educational Resources Information Center

    McLaughlin, Milbrey; London, Rebecca A.

    2013-01-01

    A societal sector perspective looks to a broad array of actors and agencies responsible for creating the community contexts that affect youth learning and development. We demonstrate the efficacy of this perspective by describing the Youth Data Archive, which allows community partners to define issues affecting youth that transcend specific…

  10. Examining the Societal Impacts of Nanotechnology through Simulation: NANO SCENARIO

    ERIC Educational Resources Information Center

    Jarmon, Leslie; Keating, Elizabeth; Toprac, Paul

    2008-01-01

    This article describes a university-sponsored experiential-based simulation, the NANO SCENARIO, to increase the public's awareness and affect attitudes on the societal implications of nanoscience and nanotechnology by bringing together diverse stakeholders' perspectives in a participatory learning environment. Nanotechnology has the potential for…

  11. Factors influencing societal response of nanotechnology: an expert stakeholder analysis.

    PubMed

    Gupta, Nidhi; Fischer, Arnout R H; van der Lans, Ivo A; Frewer, Lynn J

    2012-05-01

    Nanotechnology can be described as an emerging technology and, as has been the case with other emerging technologies such as genetic modification, different socio-psychological factors will potentially influence societal responses to its development and application. These factors will play an important role in how nanotechnology is developed and commercialised. This article aims to identify expert opinion on factors influencing societal response to applications of nanotechnology. Structured interviews with experts on nanotechnology from North West Europe were conducted using repertory grid methodology in conjunction with generalized Procrustes analysis to examine the psychological constructs underlying societal uptake of 15 key applications of nanotechnology drawn from different areas (e.g. medicine, agriculture and environment, chemical, food, military, sports, and cosmetics). Based on expert judgement, the main factors influencing societal response to different applications of nanotechnology will be the extent to which applications are perceived to be beneficial, useful, and necessary, and how 'real' and physically close to the end-user these applications are perceived to be by the public. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11051-012-0857-x) contains supplementary material, which is available to authorized users. PMID:22822302

  12. United States societal experiments via the Communications Technology Satellite

    NASA Technical Reports Server (NTRS)

    Donoughe, P. L.

    1976-01-01

    After a brief description of the Communication Technology Satellite and its U.S. coverage, the U.S. societal experiments via the CTS are discussed. These include education (college curriculum sharing, and project interchange), health care (biomedical communications, health communications, and communication support for decentralized education), and community and special experiments (satellite library information network, and transportable earth terminal).

  13. Societal Boundaries on Cybernetic Action or Decision-Making.

    ERIC Educational Resources Information Center

    Schulman, Rosalind; Steg, Doreen E.

    This paper discusses the development, application, and implications of a statistical technique--a concordance index--for measuring the restrictions and constrictions (legal and societal) which inhibit individual decision making and adapting behavior. It was found that as sophistication sets in there will be less and less tolerance of these…

  14. Character and Citizenship Education: Conversations between Personal and Societal Values

    ERIC Educational Resources Information Center

    Sim, Jasmine B.-Y.; Low, Ee Ling

    2012-01-01

    The theme of this special issue is "Character and Citizenship Education: Conversations between Personal and Societal Values." Character education and citizenship education, taken separately or as a single entity are currently riding high on the political and educational policy agendas of several governments (Arthur, 2003; Berkowitz & Bier, 2007;…

  15. White University Students' Responses to Societal Racism: A Qualitative Investigation

    ERIC Educational Resources Information Center

    Spanierman, Lisa A.; Oh, Euna; Poteat, V. Paul; Hund, Anita R.; McClair, Vetisha L.; Beer, Amanda M.; Clarke, Alexis M.

    2008-01-01

    The purpose of this investigation was to extend earlier conceptual and empirical literature on the ways in which White individuals respond to societal racism. To this end, the authors conducted in-depth interviews to examine 11 midwestern, non-Hispanic, White university students' reactions and experiences related to individual and institutional…

  16. Examining the Societal Impacts of Nanotechnology through Simulation: NANO SCENARIO

    ERIC Educational Resources Information Center

    Jarmon, Leslie; Keating, Elizabeth; Toprac, Paul

    2008-01-01

    This article describes a university-sponsored experiential-based simulation, the NANO SCENARIO, to increase the public's awareness and affect attitudes on the societal implications of nanoscience and nanotechnology by bringing together diverse stakeholders' perspectives in a participatory learning environment. Nanotechnology has the potential for…

  17. Education in Alberta: Some Major Societal Trends. Revised.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Planning and Policy Secretariat.

    The major societal trends happening in Alberta, Canada, have an impact on educational effectiveness in the region. Statistics are provided in the areas of demographics, family and society, Alberta's youth, labor force, and advances in science and technology. The section on demographics includes data on population growth, births, fertility rates,…

  18. Education in Alberta: Some Major Societal Trends. Revised.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Planning and Policy Secretariat.

    The major societal trends happening in Alberta, Canada, have an impact on educational effectiveness in the region. Statistics are provided in the areas of demographics, family and society, Alberta's youth, labor force, and advances in science and technology. The section on demographics includes data on population growth, births, fertility rates,…

  19. Economic and Societal Factors Instructional Guide. Student Materials.

    ERIC Educational Resources Information Center

    Hendrix, Mary W.

    These student materials are designed to accompany the Economic and Societal Factors Instructional Guide. Page numbers are consistent with the numbering in that guide. The guide's nine units deal with the following topics: (1) job acquisition (sources of employment, job application, completing the application form, resume, job interview, follow-up…

  20. Economic and Societal Factors Instructional Guide. Spanish Student Materials.

    ERIC Educational Resources Information Center

    Hendrix, Mary W.; And Others

    This document is the Spanish language version of the student materials component designed to accompany the Economic and Societal Factors Instructional Guide. Page numbers are consistent with the numbering in that guide. The guide's nine units deal with the following topics: (1) job acquisition (sources of employment, job application, completing…

  1. Teaching about Societal Issues in Science Classrooms. ERIC Digest.

    ERIC Educational Resources Information Center

    McCann, Wendy Sherman

    This digest reviews information in the science education literature on teaching about societal issues in science classes. Reasons for including a discussion of social issues in science classrooms are given, and instructional approaches for teaching about science and society are presented. Several Internet resources related to teaching about…

  2. Taking a Societal Sector Perspective on Youth Learning and Development

    ERIC Educational Resources Information Center

    McLaughlin, Milbrey; London, Rebecca A.

    2013-01-01

    A societal sector perspective looks to a broad array of actors and agencies responsible for creating the community contexts that affect youth learning and development. We demonstrate the efficacy of this perspective by describing the Youth Data Archive, which allows community partners to define issues affecting youth that transcend specific…

  3. Teachers' Conceptions about Their Understanding of Societal Science Issues.

    ERIC Educational Resources Information Center

    Martins, Isabel P.

    Teachers' scientific knowledge about societal science issues must be one of the prerequisites for the process of science teaching. Innovation in science teaching and its implications for students' scientific literacy depends on the understanding that teachers bring with them into the classroom. The purpose of this study was to investigate how…

  4. Societal Complexity and Familial Complexity: Evidence for the Curvilinear Hypothesis

    ERIC Educational Resources Information Center

    Blumberg, Rae Lesser; Winch, Robert F.

    1972-01-01

    The hypothesis is supported that the most extended, complex familial systems should be found among societies in an intermediate range of societal complexity, particularly among settled agricultural peoples. Among the simple hunting-gathering groups and in modern industrial states is found the nuclear family system: small, independent, nonextended…

  5. Assessing the impact on chronic disease of incorporating the societal cost of greenhouse gases into the price of food: an econometric and comparative risk assessment modelling study

    PubMed Central

    Briggs, Adam D M; Kehlbacher, Ariane; Tiffin, Richard; Garnett, Tara; Rayner, Mike; Scarborough, Peter

    2013-01-01

    Objectives To model the impact on chronic disease of a tax on UK food and drink that internalises the wider costs to society of greenhouse gas (GHG) emissions and to estimate the potential revenue. Design An econometric and comparative risk assessment modelling study. Setting The UK. Participants The UK adult population. Interventions Two tax scenarios are modelled: (A) a tax of £2.72/tonne carbon dioxide equivalents (tCO2e)/100?g product applied to all food and drink groups with above average GHG emissions. (B) As with scenario (A) but food groups with emissions below average are subsidised to create a tax neutral scenario. Outcome measures Primary outcomes are change in UK population mortality from chronic diseases following the implementation of each taxation strategy, the change in the UK GHG emissions and the predicted revenue. Secondary outcomes are the changes to the micronutrient composition of the UK diet. Results Scenario (A) results in 7770 (95% credible intervals 7150 to 8390) deaths averted and a reduction in GHG emissions of 18?683 (14?665to 22?889) ktCO2e/year. Estimated annual revenue is £2.02 (£1.98 to £2.06) billion. Scenario (B) results in 2685 (1966 to 3402) extra deaths and a reduction in GHG emissions of 15?228 (11?245to 19?492) ktCO2e/year. Conclusions Incorporating the societal cost of GHG into the price of foods could save 7770 lives in the UK each year, reduce food-related GHG emissions and generate substantial tax revenue. The revenue neutral scenario (B) demonstrates that sustainability and health goals are not always aligned. Future work should focus on investigating the health impact by population subgroup and on designing fiscal strategies to promote both sustainable and healthy diets. PMID:24154517

  6. Anticipating the Future, Influencing the Present: Assessing the Societal Implications of Emerging Technologies

    NASA Astrophysics Data System (ADS)

    Michelson, Evan S.

    A growing challenge for the American policymaking system is to respond effectively to a wide range of interconnected, complex, long-term science and technology issues. Simultaneously, current approaches and institutions of governance are ill suited to address these multidimensional challenges. As the next generation of innovations in science and technology is arriving at an accelerating rate, the governance system is lagging behind. This realization leads to a vital overarching consideration that steers this study: What approaches are well suited to anticipate the longer-term societal implications of emerging technologies in the 21st Century? This study identifies and examines strategies for anticipating the longer-term societal implications of emerging technologies by way of a qualitative case study. It explores one area of technology (nanotechnology), in one particular governance system (the United States), and with a focus on one high profile non-governmental organization (NGO) involved in addressing a range of nanotechnology's societal and policy implications: the Project on Emerging Nanotechnologies (PEN). Based at the Woodrow Wilson International Center for Scholars, PEN's goal was to ensure "that as nanotechnologies advance, possible risks are minimized, public and consumer engagement remains strong, and the potential benefits of these new technologies are realized." The conceptual framework of anticipatory governance guides the research, which offers a real-world example about how anticipatory governance applies in the nongovernmental sector and shows how this idea links to broader theoretical debates about the policymaking process. The study's main conclusion is that PEN utilized a set of interconnected strategies related to advancing foresight, operating in a boundary-spanning role, and promoting communications and public engagement in its attempt to influence, anticipate, and shape the societal implications of emerging technologies. The findings are informed by evidence from a range of sources, including document analysis, semi-structured interviews, and multiple media analyses. Finally, this study highlights a set of cross-cutting, transferable lessons that can be applied as future emerging technologies arise over time. The intention is that the insights gained from this study can help address these pressing issues as they rapidly unfold.

  7. Implementation of a parallel protein structure alignment service on cloud.

    PubMed

    Hung, Che-Lun; Lin, Yaw-Ling

    2013-01-01

    Protein structure alignment has become an important strategy by which to identify evolutionary relationships between protein sequences. Several alignment tools are currently available for online comparison of protein structures. In this paper, we propose a parallel protein structure alignment service based on the Hadoop distribution framework. This service includes a protein structure alignment algorithm, a refinement algorithm, and a MapReduce programming model. The refinement algorithm refines the result of alignment. To process vast numbers of protein structures in parallel, the alignment and refinement algorithms are implemented using MapReduce. We analyzed and compared the structure alignments produced by different methods using a dataset randomly selected from the PDB database. The experimental results verify that the proposed algorithm refines the resulting alignments more accurately than existing algorithms. Meanwhile, the computational performance of the proposed service is proportional to the number of processors used in our cloud platform. PMID:23671842

  8. Increasing Influence of Societal Response Variables in Coastal Evolution Projections (Invited)

    NASA Astrophysics Data System (ADS)

    Gayes, P. T.; McCoy, C. A.; Pietrafesa, L. J.

    2010-12-01

    Recent efforts to project changes in coastal erosion and vulnerability of the state of South Carolina’s (SC’s) oceanfront for different scenarios of future sea level have reinforced the significance of the influence of societal modifications and response to past and anticipated coastal change in these systems. For large reaches of the SC coast human interactions have been a dominant signal driving coastal change across annual to decadal scales. Over the last 20 years, SC’s shoreline has been advanced seawards in many areas due to a combination of sustained societal commitment to beach nourishment and to a lull in atmospheric storms; reversing the long-term erosional trend of shoreline change. Adjacent areas not yet threatened or where coastal defense is unsupported economically have continued to migrate landwards. Locally, efforts focused on stabilizing the subaerial beach have not moderated long-term shoreward migration of the shoreface changing the overall morphology of the coastal boundary waves and currents are operating against. These societal effects, coupled with realistic, substative assessments of future atmospheric storm activity and sea level variability, both over scales of seasons to multi-decades, require consideration to realistically project future coastal behavior across time and spatial scales for planning and resource management. As with future climate and sea level variability effects on the shoreline, the scale and intensity of societal response is not static or precisely projected spatially and temporally into the future. With continued expansion of coastal development and erosion into previously lightly developed and defended coastal areas, societal influences should be expected to increase. Increasing cost of larger scale defenses will likely drive pressure for hardened structures to enhance ”softer” nourishment strategies. However, this strategy would further modify the ability of nature to respond to natural forces. Nourishment programs are strongly cyclic and can act in or out of phase with natural cyclic (inlet migration, sea level variability) or stochastic (storms) drivers with significant effects on coastal response and predictions of coastal behavior. Economic cycles and events may similarly moderate timing and scale of coastal defense relative to natural drivers. Societal decisions to not, enhance and or even abandon and remove existing engineering structures as future forces and costs increase, can result in a disproportional response and potentially failure of a section of coast. Some communities have expressed confidence in the ability to maintain the oceanfront shoreline against most projections of sea level rise over the next 100 years. The long-term trend in sea level change may be less important than naturally occurring regional scale, seasonal to inter-annual to multi-decadal variability in sea level; and these are complex but deterministic. There is less confidence, however, in the ability to combat passive submergence and associated flooding issues behind the immediate oceanfront. To the extent that may influence commitment to defend the oceanfront could strongly influence coastal behavior and stability in the long term.

  9. Information Technology Governance Maturity: Examining the Moderating Effect on the Relationship between Strategic Alignment Maturity and Information Technology Effectiveness

    ERIC Educational Resources Information Center

    Kouakou, Claude N.

    2013-01-01

    The positive contribution of information technology (IT) in an organization is undeniable. Most organizations take advantage of that contributive benefit by aligning their business strategy with their IT strategy. This alignment is known as IT-business strategic alignment. Strategic alignment involves making the best possible use of corporate IT…

  10. Information Technology Governance Maturity: Examining the Moderating Effect on the Relationship between Strategic Alignment Maturity and Information Technology Effectiveness

    ERIC Educational Resources Information Center

    Kouakou, Claude N.

    2013-01-01

    The positive contribution of information technology (IT) in an organization is undeniable. Most organizations take advantage of that contributive benefit by aligning their business strategy with their IT strategy. This alignment is known as IT-business strategic alignment. Strategic alignment involves making the best possible use of corporate IT…

  11. Advances in understanding societal vulnerability to tsunamis in the United States

    NASA Astrophysics Data System (ADS)

    Wood, N. J.

    2009-12-01

    Loss of life and property damage from future tsunamis can be reduced if officials develop risk-reduction strategies and education programs that address how at-risk populations and communities are specifically vulnerable to tsunamis. Prior to the 2004 Indian Ocean tsunami, information concerning societal vulnerability to tsunamis in the U.S. was largely limited to state-level summaries of the number of residents within one kilometer of the coast. Since 2004, the U.S. Geological Survey has furthered the Nation’s understanding of societal vulnerability to tsunamis with several studies that describe the exposure, sensitivity, and adaptive capacity of at-risk populations in tsunami-hazard zones. Community-level assessments have been completed in Hawaii, Oregon, and Washington to document variations in the number and types of people, businesses, and critical facilities in tsunami-prone areas. A method using midresolution satellite imagery was developed to identify community variations in the amount of developed land in tsunami-prone areas. Factor analysis and geospatial analysis were integrated to model variations in demographic sensitivity to tsunamis. Public workshops have been held to examine community sensitivity, adaptive capacity and post-tsunami recovery. Results demonstrate that social vulnerability to tsunamis varies throughout a community or region and that certain areas are likely to suffer disproportionately due to differences in pre-tsunami socioeconomic conditions and other demographic attributes. This presentation will summarize advances in understanding societal vulnerability in the U.S. to tsunamis since the 2004 Indian Ocean tsunami, as well as discuss opportunities and needs for further work.

  12. Beyond Climate and Weather Science: Expanding the Forecasting Family to Serve Societal Needs

    NASA Astrophysics Data System (ADS)

    Barron, E. J.

    2009-05-01

    The ability to "anticipate" the future is what makes information from the Earth sciences valuable to society - whether it is the prediction of severe weather or the future availability of water resources in response to climate change. An improved ability to anticipate or forecast has the potential to serve society by simultaneously improving our ability to (1) promote economic vitality, (2) enable environmental stewardship, (3) protect life and property, as well as (4) improve our fundamental knowledge of the earth system. The potential is enormous, yet many appear ready to move quickly toward specific mitigation and adaptation strategies assuming that the science is settled. Five important weakness must be addressed first: (1) the formation of a true "climate services" function and capability, (2) the deliberate investment in expanding the family of forecasting elements to incorporate a broader array of environmental factors and impacts, (3) the investment in the sciences that connect climate to society, (4) a deliberate focus on the problems associated with scale, in particular the difference between the scale of predictive models and the scale associated with societal decisions, and (5) the evolution from climate services and model predictions to the equivalent of "environmental intelligence centers." The objective is to bring the discipline of forecasting to a broader array of environmental challenges. Assessments of the potential impacts of global climate change on societal sectors such as water, human health, and agriculture provide good examples of this challenge. We have the potential to move from a largely reactive mode in addressing adverse health outcomes, for example, to one in which the ties between climate, land cover, infectious disease vectors, and human health are used to forecast and predict adverse human health conditions. The potential exists for a revolution in forecasting, that entrains a much broader set of societal needs and solutions. The argument is made that (for example) the current capabilities in the prediction of environmental health is similar to the capabilities (and potential) of weather forecasting in the 1960's.

  13. The Societal and Economic Value of Rotator Cuff Repair

    PubMed Central

    Mather, Richard C.; Koenig, Lane; Acevedo, Daniel; Dall, Timothy M.; Gallo, Paul; Romeo, Anthony; Tongue, John; Williams, Gerald

    2013-01-01

    Background: Although rotator cuff disease is a common musculoskeletal problem in the United States, the impact of this condition on earnings, missed workdays, and disability payments is largely unknown. This study examines the value of surgical treatment for full-thickness rotator cuff tears from a societal perspective. Methods: A Markov decision model was constructed to estimate lifetime direct and indirect costs associated with surgical and continued nonoperative treatment for symptomatic full-thickness rotator cuff tears. All patients were assumed to have been unresponsive to one six-week trial of nonoperative treatment prior to entering the model. Model assumptions were obtained from the literature and data analysis. We obtained estimates of indirect costs using national survey data and patient-reported outcomes. Four indirect costs were modeled: probability of employment, household income, missed workdays, and disability payments. Direct cost estimates were based on average Medicare reimbursements with adjustments to an all-payer population. Effectiveness was expressed in quality-adjusted life years (QALYs). Results: The age-weighted mean total societal savings from rotator cuff repair compared with nonoperative treatment was $13,771 over a patient’s lifetime. Savings ranged from $77,662 for patients who are thirty to thirty-nine years old to a net cost to society of $11,997 for those who are seventy to seventy-nine years old. In addition, surgical treatment results in an average improvement of 0.62 QALY. Societal savings were highly sensitive to age, with savings being positive at the age of sixty-one years and younger. The estimated lifetime societal savings of the approximately 250,000 rotator cuff repairs performed in the U.S. each year was $3.44 billion. Conclusions: Rotator cuff repair for full-thickness tears produces net societal cost savings for patients under the age of sixty-one years and greater QALYs for all patients. Rotator cuff repair is cost-effective for all populations. The results of this study should not be interpreted as suggesting that all rotator cuff tears require surgery. Rather, the results show that rotator cuff repair has an important role in minimizing the societal burden of rotator cuff disease. PMID:24257656

  14. Orthodontics and Aligners

    MedlinePLUS

    ... Procedures Dental Implants Dentures Direct Bonding Implants versus Bridges Orthodontics and Aligners Periodontal Plastic Surgery Porcelain Crowns Porcelain Fixed Bridges Porcelain Veneers Repairing Chipped Teeth Teeth Whitening Tooth- ...

  15. Algorithms for Automatic Alignment of Arrays

    NASA Technical Reports Server (NTRS)

    Chatterjee, Siddhartha; Gilbert, John R.; Oliker, Leonid; Schreiber, Robert; Sheffler, Thomas J.

    1996-01-01

    Aggregate data objects (such as arrays) are distributed across the processor memories when compiling a data-parallel language for a distributed-memory machine. The mapping determines the amount of communication needed to bring operands of parallel operations into alignment with each other. A common approach is to break the mapping into two stages: an alignment that maps all the objects to an abstract template, followed by a distribution that maps the template to the processors. This paper describes algorithms for solving the various facets of the alignment problem: axis and stride alignment, static and mobile offset alignment, and replication labeling. We show that optimal axis and stride alignment is NP-complete for general program graphs, and give a heuristic method that can explore the space of possible solutions in a number of ways. We show that some of these strategies can give better solutions than a simple greedy approach proposed earlier. We also show how local graph contractions can reduce the size of the problem significantly without changing the best solution. This allows more complex and effective heuristics to be used. We show how to model the static offset alignment problem using linear programming, and we show that loop-dependent mobile offset alignment is sometimes necessary for optimum performance. We describe an algorithm with for determining mobile alignments for objects within do loops. We also identify situations in which replicated alignment is either required by the program itself or can be used to improve performance. We describe an algorithm based on network flow that replicates objects so as to minimize the total amount of broadcast communication in replication.

  16. On the societal nature of praxis and organic research

    NASA Astrophysics Data System (ADS)

    Roth, Wolff-Michael

    2014-09-01

    In its focus on social practices, the feature article presents an interesting theoretical framework for rethinking not only where and how knowing and learning in science education exhibit themselves but also we might change our own research practice. The framework is not new to me, as I have advocated it explicitly for more than 15 years. But over time it became apparent to me that some particularities of participation in practice may be grounded more strongly in an orientation towards the societal nature of any human praxis. In this forum contribution, I present a theoretical approach built on societal-historical activity theory that also takes activism as a major category for theorizing participation. This approach not only covers the extent of the social practice framework but also allows us to make thematic the production of inequity and restrictions to access science and engineering that are characteristic of many societies.

  17. On the societal nature of praxis and organic research

    NASA Astrophysics Data System (ADS)

    Roth, Wolff-Michael

    2016-03-01

    In its focus on social practices, the feature article presents an interesting theoretical framework for rethinking not only where and how knowing and learning in science education exhibit themselves but also we might change our own research practice. The framework is not new to me, as I have advocated it explicitly for more than 15 years. But over time it became apparent to me that some particularities of participation in practice may be grounded more strongly in an orientation towards the societal nature of any human praxis. In this forum contribution, I present a theoretical approach built on societal-historical activity theory that also takes activism as a major category for theorizing participation. This approach not only covers the extent of the social practice framework but also allows us to make thematic the production of inequity and restrictions to access science and engineering that are characteristic of many societies.

  18. Valuing QALY gains by applying a societal perspective.

    PubMed

    Bobinac, Ana; van Exel, N Job A; Rutten, Frans F H; Brouwer, Werner B F

    2013-10-01

    Interpreting the outcomes of cost utility analyses requires an appropriately defined threshold for costs per quality-adjusted life year (QALY). A common view is that the threshold should represent the (consumption) value a society attaches to a QALY. So far, individual valuations of personal health gains have mainly been studied rather than potentially relevant social values. In this study, we present the first direct empirical estimates of the willingness to pay for a QALY from a societal perspective. We used the contingent valuation approach, valuing QALYs under uncertainty and correcting for probability weighting. The estimates obtained in a representative sample of the Dutch population (n = 1004) range from €52,000 to €83,000, depending on the specification of the societal perspective. The scale sensitivity was weak, however. PMID:23080321

  19. Physician alignment strategies and real estate.

    PubMed

    Czerniak, Thomas A

    2012-06-01

    When addressing locations of facilities after acquiring physician practices, hospitals should: Acknowledge the hospital's ambulatory plan is the driver rather than real estate assumed with the physician practices, Review the hospital ambulatory service plan for each submarket, Review the location of facilities within the service area and their proximity to one another, Sublease or sell existing facilities that are not appropriate, Ensure that the size and characteristics of each facility in the market are appropriate and consistent with the hospital's image. PMID:22734329

  20. Aligning parallel arrays to reduce communication

    NASA Technical Reports Server (NTRS)

    Sheffler, Thomas J.; Schreiber, Robert; Gilbert, John R.; Chatterjee, Siddhartha

    1994-01-01

    Axis and stride alignment is an important optimization in compiling data-parallel programs for distributed-memory machines. We previously developed an optimal algorithm for aligning array expressions. Here, we examine alignment for more general program graphs. We show that optimal alignment is NP-complete in this setting, so we study heuristic methods. This paper makes two contributions. First, we show how local graph transformations can reduce the size of the problem significantly without changing the best solution. This allows more complex and effective heuristics to be used. Second, we give a heuristic that can explore the space of possible solutions in a number of ways. We show that some of these strategies can give better solutions than a simple greedy approach proposed earlier. Our algorithms have been implemented; we present experimental results showing their effect on the performance of some example programs running on the CM-5.

  1. ORFEUS alignment concept

    NASA Astrophysics Data System (ADS)

    Graue, R.; Kampf, D.; Rippel, H.; Witte, G.

    1991-09-01

    The alignment concept of ORFEUS, a short-term scientific space payload scheduled for launching by the STS in January 1993, is discussed. ORFEUS comprises two alternatively operating spectrometers (Echelle and Rowland) implemented in a CFC telescope with a 4-m tube length and an aperture of 1000 mm. The lightweight primary mirror has a focal length of 2426 mm. In order to achieve the required spectrometric high telescope resolution in the UV range (40-125 nm), a sophisticated alignment concept was developed. The centering of the alignment diaphragm (diameter: 15 microns) in the focus of the primary mirror has to be provided in the vertical tube position by means of an autocollimation telescope. The spectrometers have to be integrated into the horizontal telescope aligned within a special antigravity device to reduce optical surface deformations and to ensure the optical performance of the primary. The alignment of all optical components is to be performed in the visible spectral range.

  2. Societal transformation and adaptation necessary to manage dynamics in flood hazard and risk mitigation (TRANS-ADAPT)

    NASA Astrophysics Data System (ADS)

    Fuchs, Sven; Thaler, Thomas; Bonnefond, Mathieu; Clarke, Darren; Driessen, Peter; Hegger, Dries; Gatien-Tournat, Amandine; Gralepois, Mathilde; Fournier, Marie; Mees, Heleen; Murphy, Conor; Servain-Courant, Sylvie

    2015-04-01

    Facing the challenges of climate change, this project aims to analyse and to evaluate the multiple use of flood alleviation schemes with respect to social transformation in communities exposed to flood hazards in Europe. The overall goals are: (1) the identification of indicators and parameters necessary for strategies to increase societal resilience, (2) an analysis of the institutional settings needed for societal transformation, and (3) perspectives of changing divisions of responsibilities between public and private actors necessary to arrive at more resilient societies. This proposal assesses societal transformations from the perspective of changing divisions of responsibilities between public and private actors necessary to arrive at more resilient societies. Yet each risk mitigation measure is built on a narrative of exchanges and relations between people and therefore may condition the outputs. As such, governance is done by people interacting and defining risk mitigation measures as well as climate change adaptation are therefore simultaneously both outcomes of, and productive to, public and private responsibilities. Building off current knowledge this project will focus on different dimensions of adaptation and mitigation strategies based on social, economic and institutional incentives and settings, centring on the linkages between these different dimensions and complementing existing flood risk governance arrangements. The policy dimension of adaptation, predominantly decisions on the societal admissible level of vulnerability and risk, will be evaluated by a human-environment interaction approach using multiple methods and the assessment of social capacities of stakeholders across scales. As such, the challenges of adaptation to flood risk will be tackled by converting scientific frameworks into practical assessment and policy advice. In addressing the relationship between these dimensions of adaptation on different temporal and spatial scales, this project is both scientifically innovative and policy relevant, thereby supporting climate policy needs in Europe towards a concept of risk governance. Key words: climate change adaptation; transformation; flood risk management; resilience; vulnerability; innovative bottom-up developments; multifunctional use

  3. Precision alignment device

    DOEpatents

    Jones, N.E.

    1988-03-10

    Apparatus for providing automatic alignment of beam devices having an associated structure for directing, collimating, focusing, reflecting, or otherwise modifying the main beam. A reference laser is attached to the structure enclosing the main beam producing apparatus and produces a reference beam substantially parallel to the main beam. Detector modules containing optical switching devices and optical detectors are positioned in the path of the reference beam and are effective to produce an electrical output indicative of the alignment of the main beam. This electrical output drives servomotor operated adjustment screws to adjust the position of elements of the structure associated with the main beam to maintain alignment of the main beam. 5 figs.

  4. Precision alignment device

    DOEpatents

    Jones, Nelson E. (Huntington Beach, CA)

    1990-01-01

    Apparatus for providing automatic alignment of beam devices having an associated structure for directing, collimating, focusing, reflecting, or otherwise modifying the main beam. A reference laser is attached to the structure enclosing the main beam producing apparatus and produces a reference beam substantially parallel to the main beam. Detector modules containing optical switching devices and optical detectors are positioned in the path of the reference beam and are effective to produce an electrical output indicative of the alignment of the main beam. This electrical output drives servomotor operated adjustment screws to adjust the position of elements of the structure associated with the main beam to maintain alignment of the main beam.

  5. Galaxy Alignments: An Overview

    NASA Astrophysics Data System (ADS)

    Joachimi, Benjamin; Cacciato, Marcello; Kitching, Thomas D.; Leonard, Adrienne; Mandelbaum, Rachel; Schäfer, Björn Malte; Sifón, Cristóbal; Hoekstra, Henk; Kiessling, Alina; Kirk, Donnacha; Rassat, Anais

    2015-11-01

    The alignments between galaxies, their underlying matter structures, and the cosmic web constitute vital ingredients for a comprehensive understanding of gravity, the nature of matter, and structure formation in the Universe. We provide an overview on the state of the art in the study of these alignment processes and their observational signatures, aimed at a non-specialist audience. The development of the field over the past one hundred years is briefly reviewed. We also discuss the impact of galaxy alignments on measurements of weak gravitational lensing, and discuss avenues for making theoretical and observational progress over the coming decade.

  6. Hybrid vehicle motor alignment

    DOEpatents

    Levin, Michael Benjamin (Ann Arbor, MI)

    2001-07-03

    A rotor of an electric motor for a motor vehicle is aligned to an axis of rotation for a crankshaft of an internal combustion engine having an internal combustion engine and an electric motor. A locator is provided on the crankshaft, a piloting tool is located radially by the first locator to the crankshaft. A stator of the electric motor is aligned to a second locator provided on the piloting tool. The stator is secured to the engine block. The rotor is aligned to the crankshaft and secured thereto.

  7. Overview of female middle childhood in societal context: implications for research and practice.

    PubMed

    Doswell, Willa M

    2002-12-01

    Preadolescence represents a time of becoming and of change less emphasized in popular and empirical literature than adolescence. Yet it is an important period and a critical time to teach children, while they are still sufficiently adult-dependent and adult-centered, to help that learning to persist. These are formative years during which children experience marked increases in development (physical, cognitive, and psychosocial) and knowledge and an incremental shaping of values, attitudes, and behaviors that they will carry into adulthood. This period of life can also be called the "tween" years, as children during this period are transitioning to adolescence. The purpose of this article is to present an overview of the societal context in which preteen girls are developing and provide some suggestions for testing and implementing health promotion strategies that may contribute toward a safe and successful transition for these children through adolescence to adulthood in this fast-paced society. PMID:12518279

  8. It's All about Alignment.

    ERIC Educational Resources Information Center

    Barron, Tom

    2003-01-01

    Many corporations have initiated learning initiatives during the past few years. Training managers are successfully aligning organizational learning with business objectives and bringing about recognition of the relationship between work force development and corporate performance. (Author/JOW)

  9. VLTI image alignment monitoring

    NASA Astrophysics Data System (ADS)

    Gitton, Philippe B.; Cantzler, Michael; Koehler, Bertrand; Kervella, P.

    2003-02-01

    In its current configuration, the VLT Interferometer (VLTI) combines the light collected by two telescopes and directs it towards the commissioning instrument called VINCI. In an interferometer, the optical path ranging from a telescope to the point where beams are combined is referred as an arm of the interferometer. This arm contains a large number of optics that have to be aligned at installation time and kept aligned during the period of use of the interferometer. The method used to perform the initial alignment is reported in a separate article. This paper is focussed on the methods used to assess the stability of the image alignment of each interferometer arm. Collected data sets are presented and interpreted.

  10. Geospatial decision support systems for societal decision making

    USGS Publications Warehouse

    Bernknopf, R.L.

    2005-01-01

    While science provides reliable information to describe and understand the earth and its natural processes, it can contribute more. There are many important societal issues in which scientific information can play a critical role. Science can add greatly to policy and management decisions to minimize loss of life and property from natural and man-made disasters, to manage water, biological, energy, and mineral resources, and in general, to enhance and protect our quality of life. However, the link between science and decision-making is often complicated and imperfect. Technical language and methods surround scientific research and the dissemination of its results. Scientific investigations often are conducted under different conditions, with different spatial boundaries, and in different timeframes than those needed to support specific policy and societal decisions. Uncertainty is not uniformly reported in scientific investigations. If society does not know that data exist, what the data mean, where to use the data, or how to include uncertainty when a decision has to be made, then science gets left out -or misused- in a decision making process. This paper is about using Geospatial Decision Support Systems (GDSS) for quantitative policy analysis. Integrated natural -social science methods and tools in a Geographic Information System that respond to decision-making needs can be used to close the gap between science and society. The GDSS has been developed so that nonscientists can pose "what if" scenarios to evaluate hypothetical outcomes of policy and management choices. In this approach decision makers can evaluate the financial and geographic distribution of potential policy options and their societal implications. Actions, based on scientific information, can be taken to mitigate hazards, protect our air and water quality, preserve the planet's biodiversity, promote balanced land use planning, and judiciously exploit natural resources. Applications using the GDSS have demonstrated the benefits of utilizing science for policy decisions. Investment in science reduces decision-making uncertainty and reducing that uncertainty has economic value.

  11. Integrating Socioeconomic Data into GEOSS to Enable Societal Benefits

    NASA Astrophysics Data System (ADS)

    Chen, R. S.; Yetman, G.

    2009-12-01

    Achieving the GEOSS vision of societal benefits from Earth observation data is a multi-faceted challenge. Linking Earth observation systems into an interoperable system of systems is an important first step, but not sufficient on its own to fulfill the ambitious GEOSS goal of improving decision making for disaster mitigation, public health, ecosystem and resource management, agriculture, and the other societal benefit areas. Significant attention needs to be given to interdisciplinary data integration, especially with regard to incorporating data and information on human activities and welfare into monitoring, modeling, and prediction activities. For example, the ability to assess, monitor, and predict the risks posed by different natural hazards is predicated on an understanding of the underlying exposure and vulnerability of different human populations and their economic assets to past, present, and future hazardous events. The NASA Socioeconomic Data and Applications Center (SEDAC) has pioneered the integration of socioeconomic data with remote sensing data within the NASA Earth Observing System Data and Information System (EOSDIS) and has contributed actively to both phase 1 and 2 of the GEOSS Architecture Implementation Pilot. We present here several use cases for socioeconomic data integration in GEOSS and recent experience in developing an interoperable Web Processing Service (WPS) for estimating population exposure as part of the GEOSS initial operating capability. We also discuss key scientific, technical, and policy challenges to developing GEOSS products and services that will be able to meet the needs of both interdisciplinary and applied users and in so doing help achieve the GEOSS goal of generating significant societal benefits.

  12. Comprehensive safeguards evaluation methods and societal risk analysis

    SciTech Connect

    Richardson, J.M.

    1982-03-01

    Essential capabilities of an integrated evaluation methodology for analyzing safeguards systems are discussed. Such a methodology must be conceptually meaningful, technically defensible, discriminating and consistent. A decompostion of safeguards systems by function is mentioned as a possible starting point for methodology development. The application of a societal risk equation to safeguards systems analysis is addressed. Conceptual problems with this approach are discussed. Technical difficulties in applying this equation to safeguards systems are illustrated through the use of confidence intervals, information content, hypothesis testing and ranking and selection procedures.

  13. Neuroethics: the ethical, legal, and societal impact of neuroscience.

    PubMed

    Farah, Martha J

    2012-01-01

    Advances in cognitive, affective, and social neuroscience raise a host of new questions concerning the ways in which neuroscience can and should be used. These advances also challenge our intuitions about the nature of humans as moral and spiritual beings. Neuroethics is the new field that grapples with these issues. The present article surveys a number of applications of neuroscience to such diverse arenas as marketing, criminal justice, the military, and worker productivity. The ethical, legal, and societal effects of these applications are discussed. Less practical, but perhaps ultimately more consequential, is the impact of neuroscience on our worldview and our understanding of the human person. PMID:19575613

  14. Societal Statistics by virtue of the Statistical Drake Equation

    NASA Astrophysics Data System (ADS)

    Maccone, Claudio

    2012-09-01

    The Drake equation, first proposed by Frank D. Drake in 1961, is the foundational equation of SETI. It yields an estimate of the number N of extraterrestrial communicating civilizations in the Galaxy given by the product N=Ns×fp×ne×fl×fi×fc×fL, where: Ns is the number of stars in the Milky Way Galaxy; fp is the fraction of stars that have planetary systems; ne is the number of planets in a given system that are ecologically suitable for life; fl is the fraction of otherwise suitable planets on which life actually arises; fi is the fraction of inhabited planets on which an intelligent form of life evolves; fc is the fraction of planets inhabited by intelligent beings on which a communicative technical civilization develops; and fL is the fraction of planetary lifetime graced by a technical civilization. The first three terms may be called "the astrophysical terms" in the Drake equation since their numerical value is provided by astrophysical considerations. The fourth term, fl, may be called "the origin-of-life term" and entails biology. The last three terms may be called "the societal terms" inasmuch as their respective numerical values are provided by anthropology, telecommunication science and "futuristic science", respectively. In this paper, we seek to provide a statistical estimate of the three societal terms in the Drake equation basing our calculations on the Statistical Drake Equation first proposed by this author at the 2008 IAC. In that paper the author extended the simple 7-factor product so as to embody Statistics. He proved that, no matter which probability distribution may be assigned to each factor, if the number of factors tends to infinity, then the random variable N follows the lognormal distribution (central limit theorem of Statistics). This author also proved at the 2009 IAC that the Dole (1964) [7] equation, yielding the number of Habitable Planets for Man in the Galaxy, has the same mathematical structure as the Drake equation. So the number of Habitable Planets follows the lognormal distribution as well. But the Dole equation is described by the first FOUR factors of the Drake equation. Thus, we may "divide" the 7-factor Drake equation by the 4-factor Dole equation getting the probability distribution of the last-3-factor Drake equation, i.e. the probability distribution of the SOCIETAL TERMS ONLY. These we study in detail in this paper, achieving new statistical results about the SOCIETAL ASPECTS OF SETI.

  15. Pairwise Sequence Alignment Library

    Energy Science and Technology Software Center (ESTSC)

    2015-05-20

    Vector extensions, such as SSE, have been part of the x86 CPU since the 1990s, with applications in graphics, signal processing, and scientific applications. Although many algorithms and applications can naturally benefit from automatic vectorization techniques, there are still many that are difficult to vectorize due to their dependence on irregular data structures, dense branch operations, or data dependencies. Sequence alignment, one of the most widely used operations in bioinformatics workflows, has a computational footprintmore » that features complex data dependencies. The trend of widening vector registers adversely affects the state-of-the-art sequence alignment algorithm based on striped data layouts. Therefore, a novel SIMD implementation of a parallel scan-based sequence alignment algorithm that can better exploit wider SIMD units was implemented as part of the Parallel Sequence Alignment Library (parasail). Parasail features: Reference implementations of all known vectorized sequence alignment approaches. Implementations of Smith Waterman (SW), semi-global (SG), and Needleman Wunsch (NW) sequence alignment algorithms. Implementations across all modern CPU instruction sets including AVX2 and KNC. Language interfaces for C/C++ and Python.« less

  16. Pairwise Sequence Alignment Library

    SciTech Connect

    2015-05-20

    Vector extensions, such as SSE, have been part of the x86 CPU since the 1990s, with applications in graphics, signal processing, and scientific applications. Although many algorithms and applications can naturally benefit from automatic vectorization techniques, there are still many that are difficult to vectorize due to their dependence on irregular data structures, dense branch operations, or data dependencies. Sequence alignment, one of the most widely used operations in bioinformatics workflows, has a computational footprint that features complex data dependencies. The trend of widening vector registers adversely affects the state-of-the-art sequence alignment algorithm based on striped data layouts. Therefore, a novel SIMD implementation of a parallel scan-based sequence alignment algorithm that can better exploit wider SIMD units was implemented as part of the Parallel Sequence Alignment Library (parasail). Parasail features: Reference implementations of all known vectorized sequence alignment approaches. Implementations of Smith Waterman (SW), semi-global (SG), and Needleman Wunsch (NW) sequence alignment algorithms. Implementations across all modern CPU instruction sets including AVX2 and KNC. Language interfaces for C/C++ and Python.

  17. ATLAS Muon Endcap Alignment

    NASA Astrophysics Data System (ADS)

    Bensinger, James R.

    2006-01-01

    To align the endcap muon chambers of the ATLAS experiment, an optical grid is set up between aluminum "alignment bars" nested in each layer of chambers. Optical lines are made of laser diodes and CCD cameras that form an alignment grid. The alignment bars are self-aligning. They are then carefully measured using a large coordinate measuring machine (CMM). The subsequent shape changes of the bar are determined by calculations that are corrected by the readings of the internal monitors. The relationship between the bars is then established by a network of sensors that measure the bearing angle of light sources on the other parts of the system. The system is over-determined and the location and orientation of each bar is determined using a fitting program. Chambers are then referenced to the alignment grid using proximity sensors. This information is used to provide corrections to the nominal chamber positions before calculating track momentum. The performance of the system has been validated in a test beam at CERN. We have been able to track changes in muon sagitta's to an accuracy of about 15 microns under normal temperature variation and controlled movements. The system is stable over a period of months.

  18. PDV Probe Alignment Technique

    SciTech Connect

    Whitworth, T L; May, C M; Strand, O T

    2007-10-26

    This alignment technique was developed while performing heterodyne velocimetry measurements at LLNL. There are a few minor items needed, such as a white card with aperture in center, visible alignment laser, IR back reflection meter, and a microscope to view the bridge surface. The work was performed on KCP flyers that were 6 and 8 mils wide. The probes used were Oz Optics manufactured with focal distances of 42mm and 26mm. Both probes provide a spot size of approximately 80?m at 1550nm. The 42mm probes were specified to provide an internal back reflection of -35 to -40dB, and the probe back reflections were measured to be -37dB and -33dB. The 26mm probes were specified as -30dB and both measured -30.5dB. The probe is initially aligned normal to the flyer/bridge surface. This provides a very high return signal, up to -2dB, due to the bridge reflectivity. A white card with a hole in the center as an aperture can be used to check the reflected beam position relative to the probe and launch beam, and the alignment laser spot centered on the bridge, see Figure 1 and Figure 2. The IR back reflection meter is used to measure the dB return from the probe and surface, and a white card or similar object is inserted between the probe and surface to block surface reflection. It may take several iterations between the visible alignment laser and the IR back reflection meter to complete this alignment procedure. Once aligned normal to the surface, the probe should be tilted to position the visible alignment beam as shown in Figure 3, and the flyer should be translated in the X and Y axis to reposition the alignment beam onto the flyer as shown in Figure 4. This tilting of the probe minimizes the amount of light from the bridge reflection into the fiber within the probe while maintaining the alignment as near normal to the flyer surface as possible. When the back reflection is measured after the tilt adjustment, the level should be about -3dB to -6dB higher than the probes specified back reflection. This 3 to 6dB increase in back reflection from the surface relative to the probes specified back reflection is the optimal level for acquiring data from the flyer. Data obtained with the LLNL system is shown in Figure 5.

  19. Curriculum Alignment Research Suggests that Alignment Can Improve Student Achievement

    ERIC Educational Resources Information Center

    Squires, David

    2012-01-01

    Curriculum alignment research has developed showing the relationship among three alignment categories: the taught curriculum, the tested curriculum and the written curriculum. Each pair (for example, the taught and the written curriculum) shows a positive impact for aligning those results. Following this, alignment results from the Third…

  20. Cultural estrangement: the role of personal and societal value discrepancies.

    PubMed

    Bernard, Mark M; Gebauer, Jochen E; Maio, Gregory R

    2006-01-01

    Study 1 examined whether cultural estrangement arises from discrepancies between personal and societal values (e.g., freedom) rather than from discrepancies in attitudes toward political (e.g., censorship) or mundane (e.g., pizza) objects. The relations between different types of value discrepancies, estrangement, subjective well-being, and need for uniqueness also were examined. Results indicated that personal-societal discrepancies in values and political attitudes predicted estrangement, whereas mundane attitude discrepancies were not related to estrangement. As expected, value discrepancies were the most powerful predictor of estrangement. Value discrepancies were not related to subjective well-being but fulfilled a need for uniqueness. Study 2 replicated the relations between value discrepancies, subjective well-being, and need for uniqueness while showing that a self-report measure of participants' values and a peer-report measure of the participants' values yielded the same pattern of value discrepancies. Together, the studies reveal theoretical and empirical benefits of conceptualizing cultural estrangement in terms of value discrepancies. PMID:16317190

  1. PSAR-Align: improving multiple sequence alignment using probabilistic sampling

    PubMed Central

    Kim, Jaebum; Ma, Jian

    2014-01-01

    Summary:?We developed PSAR-Align, a multiple sequence realignment tool that can refine a given multiple sequence alignment based on suboptimal alignments generated by probabilistic sampling. Our evaluation demonstrated that PSAR-Align is able to improve the results from various multiple sequence alignment tools. Availability and implementation:?The PSAR-Align source code (implemented mainly in C++) is freely available for download at http://bioen-compbio.bioen.illinois.edu/PSAR-Align. Contact:?jbkim@konkuk.ac.kr or jianma@illinois.edu PMID:24222208

  2. libgapmis: extending short-read alignments

    PubMed Central

    2013-01-01

    Background A wide variety of short-read alignment programmes have been published recently to tackle the problem of mapping millions of short reads to a reference genome, focusing on different aspects of the procedure such as time and memory efficiency, sensitivity, and accuracy. These tools allow for a small number of mismatches in the alignment; however, their ability to allow for gaps varies greatly, with many performing poorly or not allowing them at all. The seed-and-extend strategy is applied in most short-read alignment programmes. After aligning a substring of the reference sequence against the high-quality prefix of a short read--the seed--an important problem is to find the best possible alignment between a substring of the reference sequence succeeding and the remaining suffix of low quality of the read--extend. The fact that the reads are rather short and that the gap occurrence frequency observed in various studies is rather low suggest that aligning (parts of) those reads with a single gap is in fact desirable. Results In this article, we present libgapmis, a library for extending pairwise short-read alignments. Apart from the standard CPU version, it includes ultrafast SSE- and GPU-based implementations. libgapmis is based on an algorithm computing a modified version of the traditional dynamic-programming matrix for sequence alignment. Extensive experimental results demonstrate that the functions of the CPU version provided in this library accelerate the computations by a factor of 20 compared to other programmes. The analogous SSE- and GPU-based implementations accelerate the computations by a factor of 6 and 11, respectively, compared to the CPU version. The library also provides the user the flexibility to split the read into fragments, based on the observed gap occurrence frequency and the length of the read, thereby allowing for a variable, but bounded, number of gaps in the alignment. Conclusions We present libgapmis, a library for extending pairwise short-read alignments. We show that libgapmis is better-suited and more efficient than existing algorithms for this task. The importance of our contribution is underlined by the fact that the provided functions may be seamlessly integrated into any short-read alignment pipeline. The open-source code of libgapmis is available at http://www.exelixis-lab.org/gapmis. PMID:24564250

  3. Cell Alignment Driven by Mechanically Induced Collagen Fiber Alignment in Collagen/Alginate Coatings.

    PubMed

    Chaubaroux, Christophe; Perrin-Schmitt, Fabienne; Senger, Bernard; Vidal, Loïc; Voegel, Jean-Claude; Schaaf, Pierre; Haikel, Youssef; Boulmedais, Fouzia; Lavalle, Philippe; Hemmerlé, Joseph

    2015-09-01

    For many years it has been a major challenge to regenerate damaged tissues using synthetic or natural materials. To favor the healing processes after tendon, cornea, muscle, or brain injuries, aligned collagen-based architectures are of utmost interest. In this study, we define a novel aligned coating based on a collagen/alginate (COL/ALG) multilayer film. The coating exhibiting a nanofibrillar structure is cross-linked with genipin for stability in physiological conditions. By stretching COL/ALG-coated polydimethylsiloxane substrates, we developed a versatile method to align the collagen fibrils of the polymeric coating. Assays on cell morphology and alignment were performed to investigate the properties of these films. Microscopic assessments revealed that cells align with the stretched collagen fibrils of the coating. The degree of alignment is tuned by the stretching rate (i.e., the strain) of the COL/ALG-coated elastic substrate. Such coatings are of great interest for strategies that require aligned nanofibrillar biological material as a substrate for tissue engineering. PMID:25658028

  4. Severe Space Weather Events--Understanding Societal and Economic Impacts: A Workshop Report - Extended Summary

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The effects of space weather on modern technological systems are well documented in both the technical literature and popular accounts. Most often cited perhaps is the collapse within 90 seconds of northeastern Canada's Hydro-Quebec power grid during the great geomagnetic storm of March 1989, which left millions of people without electricity for up to 9 hours. This event exemplifies the dramatic impact that severe space weather can have on a technology upon which modern society critically depends. Nearly two decades have passed since the March 1989 event. During that time, awareness of the risks of severe space weather has increased among the affected industries, mitigation strategies have been developed, new sources of data have become available, new models of the space environment have been created, and a national space weather infrastructure has evolved to provide data, alerts, and forecasts to an increasing number of users. Now, 20 years later and approaching a new interval of increased solar activity, how well equipped are we to manage the effects of space weather? Have recent technological developments made our critical technologies more or less vulnerable? How well do we understand the broader societal and economic impacts of severe space weather events? Are our institutions prepared to cope with the effects of a 'space weather Katrina,' a rare, but according to the historical record, not inconceivable eventuality? On May 22 and 23, 2008, a one-and-a-half-day workshop held in Washington, D.C., under the auspices of the National Research Council's (NRC's) Space Studies Board brought together representatives of industry, the federal government, and the social science community to explore these and related questions. The key themes, ideas, and insights that emerged during the presentations and discussions are summarized in 'Severe Space Weather Events--Understanding Societal and Economic Impacts: A Workshop Report' (The National Academies Press, Washington, D.C., 2008), which was prepared by the Committee on the Societal and Economic Impacts of Severe Space Weather Events: A Workshop. The present document is an expanded summary of that report.

  5. Optics Alignment Panel

    NASA Technical Reports Server (NTRS)

    Schroeder, Daniel J.

    1992-01-01

    The Optics Alignment Panel (OAP) was commissioned by the HST Science Working Group to determine the optimum alignment of the OTA optics. The goal was to find the position of the secondary mirror (SM) for which there is no coma or astigmatism in the camera images due to misaligned optics, either tilt or decenter. The despace position was reviewed of the SM and the optimum focus was sought. The results of these efforts are as follows: (1) the best estimate of the aligned position of the SM in the notation of HDOS is (DZ,DY,TZ,TY) = (+248 microns, +8 microns, +53 arcsec, -79 arcsec), and (2) the best focus, defined to be that despace which maximizes the fractional energy at 486 nm in a 0.1 arcsec radius of a stellar image, is 12.2 mm beyond paraxial focus. The data leading to these conclusions, and the estimated uncertainties in the final results, are presented.

  6. Magnetically Aligned Supramolecular Hydrogels

    PubMed Central

    Wallace, Matthew; Cardoso, Andre Zamith; Frith, William J; Iggo, Jonathan A; Adams, Dave J

    2014-01-01

    The magnetic-field-induced alignment of the fibrillar structures present in an aqueous solution of a dipeptide gelator, and the subsequent retention of this alignment upon transformation to a hydrogel upon the addition of CaCl2 or upon a reduction in solution pH is reported. Utilising the switchable nature of the magnetic field coupled with the slow diffusion of CaCl2, it is possible to precisely control the extent of anisotropy across a hydrogel, something that is generally very difficult to do using alternative methods. The approach is readily extended to other compounds that form viscous solutions at high pH. It is expected that this work will greatly expand the utility of such low-molecular-weight gelators (LMWG) in areas where alignment is key. PMID:25345918

  7. The use of individual and societal risk criteria within the Dutch flood safety policy--nationwide estimates of societal risk and policy applications.

    PubMed

    Jonkman, Sebastiaan N; Jongejan, Ruben; Maaskant, Bob

    2011-02-01

    The Dutch government is in the process of revising its flood safety policy. The current safety standards for flood defenses in the Netherlands are largely based on the outcomes of cost-benefit analyses. Loss of life has not been considered separately in the choice for current standards. This article presents the results of a research project that evaluated the potential roles of two risk metrics, individual and societal risk, to support decision making about new flood safety standards. These risk metrics are already used in the Dutch major hazards policy for the evaluation of risks to the public. Individual risk concerns the annual probability of death of a person. Societal risk concerns the probability of an event with many fatalities. Technical aspects of the use of individual and societal risk metrics in flood risk assessments as well as policy implications are discussed. Preliminary estimates of nationwide levels of societal risk are presented. Societal risk levels appear relatively high in the southwestern part of the country where densely populated dike rings are threatened by a combination of river and coastal floods. It was found that cumulation, the simultaneous flooding of multiple dike rings during a single flood event, has significant impact on the national level of societal risk. Options for the application of the individual and societal risk in the new flood safety policy are presented and discussed. PMID:20883529

  8. Alignment system for high-power large aperture laser systems

    NASA Astrophysics Data System (ADS)

    Ziano, Roberto; Accary, Jean-Baptiste; Ploetzeneder, Birgit; Versaci, Roberto; LeGarrec, Bruno

    2015-05-01

    The ELI-beamlines facility1 is being built within the Extreme Light Infrastructure (ELI) project based on the European ESFRI (European Strategy Forum on Research Infrastructures) process. The alignment of the high power lasers is an essential operation to be performed before shooting. A critical part of the alignment procedure is the definition of the references for the alignment. The most common procedure is to insert a cross shaped mask into the beam path. The centre of the cross defines the optical axis. Because of the difficulties in automatizing this procedure, a semi-automatic procedure is being used in many facilities. During such procedure an operator has to interact with the alignment system. The purpose of this work is to present the alignment process and to show how to use light sources as references for a fully automated alignment system.1, 2

  9. Space-based societal applications—Relevance in developing countries

    NASA Astrophysics Data System (ADS)

    Bhaskaranarayana, A.; Varadarajan, C.; Hegde, V. S.

    2009-11-01

    Space technology has the vast potential for addressing a variety of societal problems of the developing countries, particularly in the areas of communication, education and health sectors, land and water resources management, disaster management and weather forecasting. Both remote sensing and communication technologies can be used to achieve this goal. With its primary emphasis on application of space technology, on an end-to-end basis, towards national development, the Indian Space Programme has distinguished itself as one of the most cost-effective and development-oriented space programmes in the world. Developing nations are faced with the enormous task of carrying development-oriented education to the masses at the lower strata of their societies. One important feature of these populations is their large number and the spread over vast and remote areas of these nations, making the reaching out to them a difficult task. Satellite communication (Satcom) technology offers the unique capability of simultaneously reaching out to very large numbers, spread over vast areas, including the remote corners of the country. It is a strong tool to support development education. India has been amongst the first few nations to explore and put to use the Satcom technology for education and development-oriented services to the rural masses. Most of the developing countries have inadequate infrastructure to provide proper medical care to the rural population. Availability of specialist doctors in rural areas is a major bottleneck. Use of Satcom and information technology to connect rural clinics to urban hospitals through telemedicine systems is one of the solutions; and India has embarked upon an effective satellite-based telemedicine programme. Space technology is also useful in disaster warning and management related applications. Use of satellite systems and beacons for locating the distressed units on land, sea or air is well known to us. Indian Space Research Organisation (ISRO) is already a part of the International initiative called Satellite Aided Search and Rescue System. The programme to set up satellite-based Village Resource Centres (VRCs) across India, for providing a variety of services relevant to the rural communities, is also a unique societal application of space technology. The VRCs are envisaged as single window delivery mechanism for a variety of space-based products and services, such as tele-education; telemedicine; information on natural resources for planning and development at local level; interactive advisories on agriculture, fisheries, land and water resources management, livestock management, etc.; interactive vocational training towards alternative livelihood; e-governance; weather information; etc. This paper describes the various possibilities and potentials of Satcom and Remote Sensing technologies for societal applications. The initiatives taken by Indian Space Research Organisation in this direction are highlighted.

  10. Influence of societal and practice contexts on health professionals’ clinical reasoning: a scoping study protocol

    PubMed Central

    Carrier, Annie; Levasseur, Mélanie; Freeman, Andrew; Mullins, Gary; Quénec'hdu, Suzanne; Lalonde, Louise; Gagnon, Michaël; Lacasse, Francis

    2013-01-01

    Introduction In a context of constrained resources, the efficacy of interventions is a pivotal aim of healthcare systems worldwide. Efficacy of healthcare interventions is highly compromised if clinical reasoning (CR), the process that practitioners use to plan, direct, perform and reflect on client care, is not optimal. The CR process of health professionals is influenced by the institutional dimension (ie, legal, regulatory, administrative and organisational aspects) of their societal and practice contexts. Although several studies have been conducted with respect to the institutional dimension influencing health professionals’ CR, no clear integration of their results is yet available. The aim of this study is to synthesise and disseminate current knowledge on the influence of the institutional dimension of contexts on health professionals’ CR. Methods and analysis A scoping study of the scientific literature from January 1980 to March 2013 will be undertaken to summarise and disseminate research findings about the influence of the institutional dimension on CR. Numerous databases (n=18) from three relevant fields (healthcare, health law and politics and management) will be searched. Extended search strategies will include the manual search of bibliographies, health-related websites, public registries and journals of interest. Data will be collected and analysed using a thematic chart and content analysis. A systematic multidisciplinary team approach will allow optimal identification of relevant studies, as well as effective and valid content analysis and dissemination of the results. Discussion This scoping study will provide a rigorous, accurate and up-to-date synthesis of existing knowledge regarding: (1) those aspects of the institutional dimension of health professionals’ societal and practice contexts that impact their CR and (2) how these aspects influence health professionals’ CR. Through the synergy of a multidisciplinary research team from a wide range of expertise, clinical pertinence and an exhaustive dissemination of results to knowledge-users will be ensured. PMID:23633422

  11. Linking levels of societal and ecosystems metabolism of water in a Mediterranean watershed

    NASA Astrophysics Data System (ADS)

    Cabello, V.

    2014-12-01

    Water resources degradation is a complex environmental problem that involves multiple dimensions and scales of analysis. The Socio-Ecological Systems Water Metabolism has been proposed as a general holistic framework to deal with integrated analysis of water use sustainability (Madrid and Giampietro 2014). The innovation of the approach is that it sets the research focus beyond the classical supply-demand modeling to societal integrity and ecosystems integrity. To do so, it integrates quantitative grammars of water use (relating water exchange to societal and ecosystems organization) and qualitative methods (discourse analysis). This work presents the first case study focused at a river basin extent: the Upper Andarax, in South-East Spain. Water metabolism is indicated at multiple levels for ecosystems and society. To deal with the interfaces among them, relational indicators of water exploitation, water use and impact over ecosystems are used alongside policies and narratives analysis.While being a rather not intensively exploited river basin (year Water Exploitation Index~0.3 blue water,~0.15 green water), impacts over water bodies are yet important (periodic aquifer overdraft, biological degradation of the river) especially during dry season. Perceived mayor problems of water sustainability are generated by the not integration of different policies at European, national and regional scales: while the water authority establishes a compulsory reduction over water withdrawal to attend environmental flows, agricultural markets force to raise productivity increasing water demands. Adaptation strategies are divided among irrigation efficiency improvement and a reorientation of the economy towards touristic activities. Both of them entail specific trade-offs to be deemed. Aquifer-river interactions and climate change impacts are yet mayor research challenges.

  12. Segment alignment control system

    NASA Technical Reports Server (NTRS)

    Aubrun, JEAN-N.; Lorell, Ken R.

    1988-01-01

    The segmented primary mirror for the LDR will require a special segment alignment control system to precisely control the orientation of each of the segments so that the resulting composite reflector behaves like a monolith. The W.M. Keck Ten Meter Telescope will utilize a primary mirror made up of 36 actively controlled segments. Thus the primary mirror and its segment alignment control system are directly analogous to the LDR. The problems of controlling the segments in the face of disturbances and control/structures interaction, as analyzed for the TMT, are virtually identical to those for the LDR. The two systems are briefly compared.

  13. Orientation and Alignment Echoes

    NASA Astrophysics Data System (ADS)

    Karras, G.; Hertz, E.; Billard, F.; Lavorel, B.; Hartmann, J.-M.; Faucher, O.; Gershnabel, Erez; Prior, Yehiam; Averbukh, Ilya Sh.

    2015-04-01

    We present one of the simplest classical systems featuring the echo phenomenon—a collection of randomly oriented free rotors with dispersed rotational velocities. Following excitation by a pair of time-delayed impulsive kicks, the mean orientation or alignment of the ensemble exhibits multiple echoes and fractional echoes. We elucidate the mechanism of the echo formation by the kick-induced filamentation of phase space, and provide the first experimental demonstration of classical alignment echoes in a thermal gas of CO2 molecules excited by a pair of femtosecond laser pulses.

  14. Spatiotemporal Alignment of Visual Signals on a Special Manifold.

    PubMed

    Li, Ruonan; Chellappa, Rama

    2013-03-01

    We investigate the problem of spatiotemporal alignment of videos, signals, or feature sequences extracted from them. Specifically, we consider the scenario where the spatiotemporal misalignments can be characterized by parametric transformations. Using a nonlinear analytical structure referred to as an alignment manifold, we formulate the alignment problem as an optimization problem on this nonlinear space. We focus our attention on semantically meaningful videos or signals, e.g., those describing or capturing human motion or activities, and propose a new formalism for temporal alignment accounting for executing rate variations among instances of the same video event. The strategy taken in this effort bridges the family of geometric optimization and the family of stochastic algorithms: We regard the search for optimal alignment parameters as a recursive state estimation problem for a particular dynamic system evolving on the alignment manifold. Subsequently, a Sequential Importance Sampling procedure on the alignment manifold is designed for effective alignment. We further extend the basic Sequential Importance Sampling algorithm into a new version called Stochastic Gradient Sequential Importance Sampling, in which we incorporate a steepest descent structure on the alignment manifold and provide a more efficient particle propagation mechanism. We demonstrate the performance of alignment using manifolds on several types of input data that arise in vision problems. PMID:22778150

  15. AIMFAST: Alignment Implementation for Manufacturing

    Energy Science and Technology Software Center (ESTSC)

    2012-09-13

    AIMFAST is a software code used to align facets on a dish concentrator to a specific aimpoint strategy to minimize peak fluxes and maximize system optical performance. AIMFAST uses a large monitor or projections screen to display fringe patterns, and a machine vision camera to image the reflection of these patterns in the subject dish mirrors. From these images, a detailed map of surface normals can be generated and compared to design or fitted mirrormore » shapes. This fitted comparison is then used to develop a single vector representing the orientation of the facets relative to the design orientation, and provide near-real-time adjustment information to a communicating computer. The communicating computer can display adjustments or directly interface with adjustment tools. The software for the communicating computer is specific to the implementation and is not a part of AIMFAST.« less

  16. AIMFAST: Alignment Implementation for Manufacturing

    SciTech Connect

    2012-09-13

    AIMFAST is a software code used to align facets on a dish concentrator to a specific aimpoint strategy to minimize peak fluxes and maximize system optical performance. AIMFAST uses a large monitor or projections screen to display fringe patterns, and a machine vision camera to image the reflection of these patterns in the subject dish mirrors. From these images, a detailed map of surface normals can be generated and compared to design or fitted mirror shapes. This fitted comparison is then used to develop a single vector representing the orientation of the facets relative to the design orientation, and provide near-real-time adjustment information to a communicating computer. The communicating computer can display adjustments or directly interface with adjustment tools. The software for the communicating computer is specific to the implementation and is not a part of AIMFAST.

  17. Estimating sign-dependent societal preferences for quality of life.

    PubMed

    Attema, Arthur E; Brouwer, Werner B F; l'Haridon, Olivier; Pinto, Jose Luis

    2015-09-01

    This paper is the first to apply prospect theory to societal health-related decision making. In particular, we allow for utility curvature, equity weighting, sign-dependence, and loss aversion in choices concerning quality of life of other people. We find substantial inequity aversion, both for gains and losses, which can be attributed to both diminishing marginal utility and differential weighting of better-off and worse-off. There are also clear framing effects, which violate expected utility. Moreover, we observe loss aversion, indicating that subjects give more weight to one group's loss than another group's gain of the same absolute magnitude. We also elicited some information on the effect of the age of the studied group. The amount of inequity aversion is to some extent influenced by the age of the considered patients. In particular, more inequity aversion is observed for gains of older people than gains of younger people. PMID:26263893

  18. Traditional acupuncturists and higher education in Britain: the dual, paradoxical impact of biomedical alignment on the holistic view.

    PubMed

    Givati, Assaf; Hatton, Kieron

    2015-04-01

    Traditional acupuncturists' quest for external legitimacy in Britain involves the standardization of their knowledge bases through the development of training schools and syllabi, formal educational structures, and, since the 1990s, the teaching of undergraduate courses within (or validated by) Higher Education Institutions (HEIs), a process which entails biomedical alignment of the curriculum. However, as holistic discourses were commonly used as a rhetorical strategy by CAM practitioners to distance themselves from biomedicine and as a source of public appeal, this 'mainstreaming' process evoked practitioners' concerns that their holistic claims are being compromised. An additional challenge is being posed by a group of academics and scientists in Britain who launched an attack on CAM courses taught in HEIs, accusing them of being 'unscientific' and 'non-academic' in nature. This paper explores the negotiation of all these challenges during the formalization of traditional acupuncture education in Britain, with a particular focus on the role of HEIs. The in-depth qualitative investigation draws on several data sets: participant observation in a university validated acupuncture course; in-depth interviews; and documentary analysis. The findings show how, as part of the formalization process, acupuncturists in Britain (re)negotiate their holistic, anti-reductionist discourses and claims in relation to contemporary societal, political and cultural forces. Moreover, the teaching and validation of acupuncture courses by HEIs may contribute to broadening acupuncturists' 'holistic awareness' of societal and cultural influences on individuals' and communities' ill-health. This investigation emphasises the dynamic and context-specific (rather than fixed and essentialized) nature of acupuncture practice and knowledge. PMID:25779622

  19. Development of an Updated Societal-Risk Goal for Nuclear Power Safety

    SciTech Connect

    Vicki Bier; Michael Corradini; Robert Youngblood; Caleb Roh; Shuji Liu

    2014-07-01

    This report briefly summarizes work done in FY 2013 on the subject LDRD. The working hypothesis is that societal disruption should be addressed in a safety goal. This is motivated by the point that the Fukushima disaster resulted in very little public dose, but enormous societal disruption; a goal that addressed societal disruption would fill a perceived gap in the US NRC safety goal structure. This year's work entailed analyzing the consequences of postulated accidents at various reactor sites in the US, specifically with a view to quantifying the number of people relocated and the duration of their relocation, to see whether this makes sense as a measure of societal disruption.

  20. Optically Aligned Drill Press

    NASA Technical Reports Server (NTRS)

    Adderholdt, Bruce M.

    1994-01-01

    Precise drill press equipped with rotary-indexing microscope. Microscope and drill exchange places when turret rotated. Microscope axis first aligned over future hole, then rotated out of way so drill axis assumes its precise position. New procedure takes less time to locate drilling positions and produces more accurate results. Apparatus adapted to such other machine tools as milling and measuring machines.

  1. Curriculum Alignment: Establishing Coherence

    ERIC Educational Resources Information Center

    Gagné, Philippe; Dumont, Laurence; Brunet, Sabine; Boucher, Geneviève

    2013-01-01

    In this paper, we present a step-by-step guide to implement a curricular alignment project, directed at professional development and student support, and developed in a higher education French as a second language department. We outline best practices and preliminary results from our experience and provide ways to adapt our experience to other…

  2. Aligning brains and minds

    PubMed Central

    Tong, Frank

    2012-01-01

    In this issue of Neuron, Haxby and colleagues describe a new method for aligning functional brain activity patterns across participants. Their study demonstrates that objects are similarly represented across different brains, allowing for reliable classification of one person’s brain activity based on another’s. PMID:22017984

  3. Aligning Post-Secondary Educational Choices to Societal Needs: A New Scholarship System for Qatar. Technical Report

    ERIC Educational Resources Information Center

    Augustine, Catherine H.; Krop, Cathy

    2008-01-01

    Qatar is experiencing previously unprecedented social and economic development, linked to increased participation in the global market. Growing employment opportunities for Qatari nationals require greater attention to post-secondary education and the development of specific high-demand skills. Since the 1970s, Qatar has complemented its…

  4. Aligning Post-Secondary Educational Choices to Societal Needs: A New Scholarship System for Qatar. Technical Report Summary

    ERIC Educational Resources Information Center

    Augustine, Catherine H.; Krop, Cathy

    2008-01-01

    Qatar is experiencing previously unprecedented social and economic development, linked to increased participation in the global market. Growing employment opportunities for Qatari nationals require greater attention to post-secondary education and the development of specific high-demand skills. Since the 1970s, Qatar has complemented its…

  5. Intervention Strategies for Sexual Abuse.

    ERIC Educational Resources Information Center

    Rencken, Robert H.

    This book provides a framework for understanding the dimensions (scope, taxonomy, philosophy) and dynamics (individual, familial, and societal) of child sexual abuse. The major focus is on integrated intervention strategies for any professional who must work with incomplete information. Chapter 1 provides an overview of the problem of child sexual…

  6. Intervention Strategies for Sexual Abuse.

    ERIC Educational Resources Information Center

    Rencken, Robert H.

    This book provides a framework for understanding the dimensions (scope, taxonomy, philosophy) and dynamics (individual, familial, and societal) of child sexual abuse. The major focus is on integrated intervention strategies for any professional who must work with incomplete information. Chapter 1 provides an overview of the problem of child sexual…

  7. MUSE alignment onto VLT

    NASA Astrophysics Data System (ADS)

    Laurent, Florence; Renault, Edgard; Boudon, Didier; Caillier, Patrick; Daguisé, Eric; Dupuy, Christophe; Jarno, Aurélien; Lizon, Jean-Louis; Migniau, Jean-Emmanuel; Nicklas, Harald; Piqueras, Laure

    2014-07-01

    MUSE (Multi Unit Spectroscopic Explorer) is a second generation Very Large Telescope (VLT) integral field spectrograph developed for the European Southern Observatory (ESO). It combines a 1' x 1' field of view sampled at 0.2 arcsec for its Wide Field Mode (WFM) and a 7.5"x7.5" field of view for its Narrow Field Mode (NFM). Both modes will operate with the improved spatial resolution provided by GALACSI (Ground Atmospheric Layer Adaptive Optics for Spectroscopic Imaging), that will use the VLT deformable secondary mirror and 4 Laser Guide Stars (LGS) foreseen in 2015. MUSE operates in the visible wavelength range (0.465-0.93 μm). A consortium of seven institutes is currently commissioning MUSE in the Very Large Telescope for the Preliminary Acceptance in Chile, scheduled for September, 2014. MUSE is composed of several subsystems which are under the responsibility of each institute. The Fore Optics derotates and anamorphoses the image at the focal plane. A Splitting and Relay Optics feed the 24 identical Integral Field Units (IFU), that are mounted within a large monolithic structure. Each IFU incorporates an image slicer, a fully refractive spectrograph with VPH-grating and a detector system connected to a global vacuum and cryogenic system. During 2012 and 2013, all MUSE subsystems were integrated, aligned and tested to the P.I. institute at Lyon. After successful PAE in September 2013, MUSE instrument was shipped to the Very Large Telescope in Chile where that was aligned and tested in ESO integration hall at Paranal. After, MUSE was directly transported, fully aligned and without any optomechanical dismounting, onto VLT telescope where the first light was overcame the 7th of February, 2014. This paper describes the alignment procedure of the whole MUSE instrument with respect to the Very Large Telescope (VLT). It describes how 6 tons could be move with accuracy better than 0.025mm and less than 0.25 arcmin in order to reach alignment requirements. The success of the MUSE alignment is demonstrated by the excellent results obtained onto MUSE image quality and throughput directly onto the sky.

  8. Societal views and animal welfare science: understanding why the modified cage may fail and other stories.

    PubMed

    Weary, D M; Ventura, B A; von Keyserlingk, M A G

    2016-02-01

    The innovations developed by scientists working on animal welfare are often not adopted in practice. In this paper, we argue that one important reason for this failure is that the solutions proposed do not adequately address the societal concerns that motivated the original research. Some solutions also fail because they do not adequately address perceived constraints within the industry. Using examples from our own recent work, we show how research methods from the social sciences can address both of these limitations. For example, those who persist in tail-docking cattle (despite an abundance of evidence showing that the practice has no benefits) often justify their position by citing concern for cow cleanliness. This result informs the nature of new extension efforts directed at farmers that continue to tail dock, suggesting that these efforts will be more effective if they focus on providing producers with methods (of proven efficacy) for keeping cows clean. Work on pain mitigation for dehorning shows that some participants reluctant to provide pain relief believe that the pain from this procedure is short lasting and has little impact on the calf. This result informs the direction of new biological research efforts to understand both the magnitude and duration of any suffering that result from this type of procedure. These, and other examples, illustrate how social science methodologies can document the shared and divergent values of different stakeholders (to ensure that proposed solutions align with mainstream values), beliefs regarding the available evidence (to help target new scientific research that meets the perceived gaps), and barriers in implementing changes (to ease adoption of ideas by addressing these barriers). PMID:26206166

  9. Inflation by alignment

    SciTech Connect

    Burgess, C.P.; Roest, Diederik

    2015-06-08

    Pseudo-Goldstone bosons (pGBs) can provide technically natural inflatons, as has been comparatively well-explored in the simplest axion examples. Although inflationary success requires trans-Planckian decay constants, f≳M{sub p}, several mechanisms have been proposed to obtain this, relying on (mis-)alignments between potential and kinetic energies in multiple-field models. We extend these mechanisms to a broader class of inflationary models, including in particular the exponential potentials that arise for pGB potentials based on noncompact groups (and so which might apply to moduli in an extra-dimensional setting). The resulting potentials provide natural large-field inflationary models and can predict a larger primordial tensor signal than is true for simpler single-field versions of these models. In so doing we provide a unified treatment of several alignment mechanisms, showing how each emerges as a limit of the more general setup.

  10. Nuclear reactor alignment plate configuration

    DOEpatents

    Altman, David A; Forsyth, David R; Smith, Richard E; Singleton, Norman R

    2014-01-28

    An alignment plate that is attached to a core barrel of a pressurized water reactor and fits within slots within a top plate of a lower core shroud and upper core plate to maintain lateral alignment of the reactor internals. The alignment plate is connected to the core barrel through two vertically-spaced dowel pins that extend from the outside surface of the core barrel through a reinforcement pad and into corresponding holes in the alignment plate. Additionally, threaded fasteners are inserted around the perimeter of the reinforcement pad and into the alignment plate to further secure the alignment plate to the core barrel. A fillet weld also is deposited around the perimeter of the reinforcement pad. To accomodate thermal growth between the alignment plate and the core barrel, a gap is left above, below and at both sides of one of the dowel pins in the alignment plate holes through with the dowel pins pass.

  11. Ontology Alignment Repair through Modularization and Confidence-Based Heuristics

    PubMed Central

    Santos, Emanuel; Faria, Daniel; Pesquita, Catia; Couto, Francisco M.

    2015-01-01

    Ontology Matching aims at identifying a set of semantic correspondences, called an alignment, between related ontologies. In recent years, there has been a growing interest in efficient and effective matching methods for large ontologies. However, alignments produced for large ontologies are often logically incoherent. It was only recently that the use of repair techniques to improve the coherence of ontology alignments began to be explored. This paper presents a novel modularization technique for ontology alignment repair which extracts fragments of the input ontologies that only contain the necessary classes and relations to resolve all detectable incoherences. The paper presents also an alignment repair algorithm that uses a global repair strategy to minimize both the degree of incoherence and the number of mappings removed from the alignment, while overcoming the scalability problem by employing the proposed modularization technique. Our evaluation shows that our modularization technique produces significantly small fragments of the ontologies and that our repair algorithm produces more complete alignments than other current alignment repair systems, while obtaining an equivalent degree of incoherence. Additionally, we also present a variant of our repair algorithm that makes use of the confidence values of the mappings to improve alignment repair. Our repair algorithm was implemented as part of AgreementMakerLight, a free and open-source ontology matching system. PMID:26710335

  12. Ontology Alignment Repair through Modularization and Confidence-Based Heuristics.

    PubMed

    Santos, Emanuel; Faria, Daniel; Pesquita, Catia; Couto, Francisco M

    2015-01-01

    Ontology Matching aims at identifying a set of semantic correspondences, called an alignment, between related ontologies. In recent years, there has been a growing interest in efficient and effective matching methods for large ontologies. However, alignments produced for large ontologies are often logically incoherent. It was only recently that the use of repair techniques to improve the coherence of ontology alignments began to be explored. This paper presents a novel modularization technique for ontology alignment repair which extracts fragments of the input ontologies that only contain the necessary classes and relations to resolve all detectable incoherences. The paper presents also an alignment repair algorithm that uses a global repair strategy to minimize both the degree of incoherence and the number of mappings removed from the alignment, while overcoming the scalability problem by employing the proposed modularization technique. Our evaluation shows that our modularization technique produces significantly small fragments of the ontologies and that our repair algorithm produces more complete alignments than other current alignment repair systems, while obtaining an equivalent degree of incoherence. Additionally, we also present a variant of our repair algorithm that makes use of the confidence values of the mappings to improve alignment repair. Our repair algorithm was implemented as part of AgreementMakerLight, a free and open-source ontology matching system. PMID:26710335

  13. The Globalization of Higher Education as a Societal and Cultural Security Problem

    ERIC Educational Resources Information Center

    Samier, Eugenie A.

    2015-01-01

    In this article, I propose a theory of the globalization of higher education as societal and cultural security problems for many regions of the world. The first section examines the field of security studies for theoretical frameworks appropriate to critiquing globalized higher education, including critical human, societal and cultural security…

  14. Societal and Economic Engagement of Universities in Finland: An Evaluation Model

    ERIC Educational Resources Information Center

    Ritsila, Jari; Nieminen, Mika; Sotarauta, Markku; Lahtonen, Jukka

    2008-01-01

    This paper is based on the work of an expert team invited by the Ministry of Education of Finland to develop criteria and an evaluation framework for societal and economic engagement for use in university performance management. The paper maps out possible indicators for the societal and economic engagement of universities in the light of national…

  15. Societal Culture and Teachers' Responses to Curriculum Reform: Experiences from China

    ERIC Educational Resources Information Center

    Yin, Hong-biao

    2013-01-01

    Educational change is intrinsically bound to the cultural characteristics of the society. However, the relationship between educational change and societal culture is rarely explored, especially in the context of mainland China. Following a 3-year qualitative research project, the present study explored the influence of societal culture on…

  16. The Societal Dimension in German Science Education--From Tradition towards Selected Cases and Recent Developments

    ERIC Educational Resources Information Center

    Marks, Ralf; Stuckey, Marc; Belova, Nadja; Eilks, Ingo

    2014-01-01

    This paper reflects the theory and practice of societal-oriented science education in the past and present of German science teaching. Starting from a quite unique German justification for more thorough societal-oriented science education and some historical reflections a model for socio-scientific issues-based science teaching will be presented.…

  17. The Globalization of Higher Education as a Societal and Cultural Security Problem

    ERIC Educational Resources Information Center

    Samier, Eugenie A.

    2015-01-01

    In this article, I propose a theory of the globalization of higher education as societal and cultural security problems for many regions of the world. The first section examines the field of security studies for theoretical frameworks appropriate to critiquing globalized higher education, including critical human, societal and cultural security…

  18. Knowledge as a Common Good: The Societal Relevance of Scientific Research

    ERIC Educational Resources Information Center

    Bouter, Lex M.

    2010-01-01

    Universities are, to a large extent, publicly funded. It is reasonable to expect that society should benefit as a result. This means that scientific research should at least have a potential societal impact. Universities and individual researchers should therefore give serious thought to the societal relevance of their research activities and…

  19. The Need for Change in Industrial Arts Based on Societal and Industrial Conditions.

    ERIC Educational Resources Information Center

    Barry, Owen J.

    The author has presented a historical review of societal/industrial conditions affecting the development of manual education to determine if a need for change in industrial arts exists at the present time. Societal conditions, industrial conditions, and the resulting educational response are examined in: Russia (mid-19th century), Sweden (19th…

  20. The Societal Dimension in German Science Education--From Tradition towards Selected Cases and Recent Developments

    ERIC Educational Resources Information Center

    Marks, Ralf; Stuckey, Marc; Belova, Nadja; Eilks, Ingo

    2014-01-01

    This paper reflects the theory and practice of societal-oriented science education in the past and present of German science teaching. Starting from a quite unique German justification for more thorough societal-oriented science education and some historical reflections a model for socio-scientific issues-based science teaching will be presented.…

  1. Alignment reference device

    DOEpatents

    Patton, Gail Y. (Sunnyvale, CA); Torgerson, Darrel D. (Palo Alto, CA)

    1987-01-01

    An alignment reference device provides a collimated laser beam that minimizes angular deviations therein. A laser beam source outputs the beam into a single mode optical fiber. The output end of the optical fiber acts as a source of radiant energy and is positioned at the focal point of a lens system where the focal point is positioned within the lens. The output beam reflects off a mirror back to the lens that produces a collimated beam.

  2. MROI's Automated Alignment System

    NASA Astrophysics Data System (ADS)

    Shtromberg, Alisa V.; Jurgenson, C. A.; Paz, M. T.; Steenson, J. M.; Berger, L.

    2007-12-01

    The Magdalena Ridge Observatory Interferometer (MROI) will be a reconfigurable (7.5-345 meter baselines) 10 element optical/near-infrared imaging interferometer atop Magdalena Ridge, 30 miles west of Socorro, NM. Depending on the location of each unit telescope, light can travel distances ranging from 460 to 660 meters via several reflections that redirect the beam's path through the beam relay trains, delay lines, beam reducing telescope, switchyards and finally to the beam combiners. All of these sub-systems comprise the three major optical axes of the MROI defined by the unit telescope (UT), the delay lines and the beam reducer (DL/BR), and the beam combiners (BC). The purpose of the alignment system is to provide a method of coaligning these three axes. One major obstacle in designing the automated alignment system (AAS) is the required simultaneous measurements from the visible through near-IR wavelengths. Another difficulty is making it fully automated, which has not been accomplished at other optical/near-IR interferometers. The conceptual design of the AAS has been completed and is currently in its preliminary design phase with some prototyping already commenced. Here is presented the current outline and progress of MROI's automated alignment system design and some results of the prototyping.

  3. Information Assurance Alignment: A Study of Performance Impacts

    ERIC Educational Resources Information Center

    Ghezal, Said

    2011-01-01

    The positive effect on performance of the alignment between a business strategy and its different functional strategies has a wide support in the literature. As an emerging functional area, information assurance has come to play a strategic role by providing all departments and functions across an organization with a reliable, safe, and efficient…

  4. Alignment and alignment transition of bent core nematics

    NASA Astrophysics Data System (ADS)

    Elamain, Omaima; Hegde, Gurumurthy; Komitov, Lachezar

    2013-07-01

    We report on the alignment of nematics consisting of bimesogen bent core molecules of chlorine substituent of benzene derivative and their binary mixture with rod like nematics. It was found that the alignment layer made from polyimide material, which is usually used for promoting vertical (homeotropic) alignment of rod like nematics, promotes instead a planar alignment of the bent core nematic and its nematic mixtures. At higher concentration of the rod like nematic component in these mixtures, a temperature driven transition from vertical to planar alignment was found near the transition to isotropic phase.

  5. Societal and economic valuation of technology-transfer deals

    NASA Astrophysics Data System (ADS)

    Holmes, Joseph S., Jr.

    2009-09-01

    The industrial adoption of concepts such as open innovation brings new legitimacy to activities technology-transfer professionals have conducted for over 20 years. This movement highlights the need for an increased understanding of the valuation of intellectual property (IP) and technology-transfer deals. Valuation, though a centerpiece of corporate finance, is more challenging when applied to the inherent uncertainty surrounding innovation. Technology-transfer professionals are often overwhelmed by the complexity and data requirements of valuation techniques and skeptical of their applicability to and utility for technology transfer. The market longs for an approach which bridges the gap between valuation fundamentals and technology-transfer realities. This paper presents the foundations of a simple, flexible, precise/accurate, and useful framework for considering the valuation of technology-transfer deals. The approach is predicated on a 12-factor model—a 3×4 value matrix predicated on categories of economic, societal, and strategic value. Each of these three categories consists of three core subcategories followed by a fourth "other" category to facilitate inevitable special considerations. This 12-factor value matrix provides a framework for harvesting data during deals and for the application of best-of-breed valuation techniques which can be employed on a per-factor basis. Future work will include framework implementation within a database platform.

  6. The influence of societal factors on female body image.

    PubMed

    Monteath, S A; McCabe, M P

    1997-12-01

    This study was designed to identify factors associated with the perceptual and attitudinal components of female body image. The influence of society and factors thought to mediate the relationship between body image and society (field dependence, locus of control, and self-esteem) were investigated. Age and body mass index (BMI) were also included as independent variables. A total of 101 female university students in Australia ranging in age from 18 to 55 years (M = 24.11) participated in the study. A video camera apparatus (VCA) was used to assess perceptual distortion of body size. The VCA, the Body Esteem Scale, and the Appearance Evaluation subscale of the Multidimensional Body Self Relations Questionnaire were used to assess body satisfaction. On average, women underestimated their body sizes by 4%, and they typically wanted to be smaller than their actual body sizes. About two fifths of the women expressed moderate to strong negative feelings about both individual body parts and their bodies as a whole. Multiple regression analyses revealed that perceptual distortion of body size could not be predicted from the independent variables. Body satisfaction was best explained by societal factors, self-esteem, and BMI. PMID:9414624

  7. Catchment Classification and Services, Considering Societal Needs in Classification

    NASA Astrophysics Data System (ADS)

    Wagener, T.

    2008-12-01

    Hydrologists do not yet possess a generally accepted catchment classification system. A general framework for catchment classification should consider variability in relevant physical and behavioral characteristics, increasing human impacts on catchments, and the assumption that our climate is changing. Any classification system should explicitly account for uncertainty and have predictive power, rather than just being descriptive. A potential extension to catchment classification lies in the inclusion of catchment services and disservices, which would explicitly link hydrology to current and future societal issues. Such a framework can describe catchment climate and form to map these on catchment function (include partition, storage and release of water, energy and matter). Climate, form, and function can be described using indices, distributions, or even conceptual models; and uncertainty needs to be preserved in individual descriptors as well as in their mapping onto each other. Descriptors of catchment function are discussed as signatures of catchment behavior, which in turn are related to catchment services and disservices. This mapping ultimately provides predictive skill by constraining the expected function at ungauged locations, even under potential nonstationarity, through knowledge of form and/or climate. Establishing this framework would provide an organizing principle, create a common language, guide modeling and measurement efforts, provide constraints on predictions in ungauged basins, and allow estimates of environmental change impacts.

  8. Alignment uncertainty and genomic analysis.

    PubMed

    Wong, Karen M; Suchard, Marc A; Huelsenbeck, John P

    2008-01-25

    The statistical methods applied to the analysis of genomic data do not account for uncertainty in the sequence alignment. Indeed, the alignment is treated as an observation, and all of the subsequent inferences depend on the alignment being correct. This may not have been too problematic for many phylogenetic studies, in which the gene is carefully chosen for, among other things, ease of alignment. However, in a comparative genomics study, the same statistical methods are applied repeatedly on thousands of genes, many of which will be difficult to align. Using genomic data from seven yeast species, we show that uncertainty in the alignment can lead to several problems, including different alignment methods resulting in different conclusions. PMID:18218900

  9. Atlas Inner Detector Alignment

    NASA Astrophysics Data System (ADS)

    Bocci, A.

    2008-06-01

    The ATLAS experiment is a multi-purpose particle detector that will study high-energy particle collisions produced by the Large Hadron Collider at CERN. In order to achieve its physics goals, the ATLAS tracking requires that the positions of the silicon detector elements have to be known to a precision better than 10 μm. Several track-based alignment algorithms have been developed for the Inner Detector. An extensive validation has been performed with simulated events and real data coming from the ATLAS. Results from such validation are reported in this paper.

  10. Self-Aligning Coupler

    NASA Technical Reports Server (NTRS)

    Cooney, Earl T.

    1990-01-01

    Joint reduces assembly time and eliminates fumbling. Self-aligning coupler easy to use for people wearing heavy gloves or other restrictive clothing. Consists of two threaded sections, one with blade, other with slot - joined by threaded collar. Blade fits precisely in slot. Notch in blade engages pin in slot to form temporary attachment. Collar turned on continuous thread of joined sections to form tight, rigid joint. Designed for assembly of structures by astronauts in space suits, coupler used on Earth by firefighters wearing protective garments, technicians handling hazardous materials, and others working underwater or in other difficult environments.

  11. Analysis of Critical Earth Observation Priorities for Societal Benefit

    NASA Astrophysics Data System (ADS)

    Zell, E. R.; Huff, A. K.; Carpenter, A. T.; Friedl, L.

    2011-12-01

    To ensure that appropriate near real-time (NRT) and historical Earth observation data are available to benefit society and meet end-user needs, the Group on Earth Observations (GEO) sponsored a multi-disciplinary study to identify a set of critical and common Earth observations associated with 9 Societal Benefit Areas (SBAs): Agriculture, Biodiversity, Climate, Disasters, Ecosystems, Energy, Health, Water, and Weather. GEO is an intergovernmental organization working to improve the availability, access, and use of Earth observations to benefit society through a Global Earth Observation System of Systems (GEOSS). The study, overseen by the GEO User Interface Committee, focused on the "demand" side of Earth observation needs: which users need what types of data, and when? The methodology for the study was a meta-analysis of over 1,700 publicly available documents addressing Earth observation user priorities, under the guidance of expert advisors from around the world. The result was a ranking of 146 Earth observation parameters that are critical and common to multiple SBAs, based on an ensemble of 4 statistically robust methods. Within the results, key details emerged on NRT observations needed to serve a broad community of users. The NRT observation priorities include meteorological parameters, vegetation indices, land cover and soil property observations, water body and snow cover properties, and atmospheric composition. The results of the study and examples of NRT applications will be presented. The applications are as diverse as the list of priority parameters. For example, NRT meteorological and soil moisture information can support monitoring and forecasting for more than 25 infectious diseases, including epidemic diseases, such as malaria, and diseases of major concern in the U.S., such as Lyme disease. Quickly evolving events that impact forests, such as fires and insect outbreaks, can be monitored and forecasted with a combination of vegetation indices, fuel moisture content, burn scars, and meteorological parameters. Impacts to public health and livelihoods due to food insecurity, algal blooms, and air pollution can be addressed through NRT monitoring of specific events utilizing land cover, atmospheric composition, water quality, and meteorological observations. More broadly, the assessment of water availability for drinking and agriculture and the development of floods and storms rely on continuous feeds of NRT meteorological and atmospheric composition observations. Overall, this multi-disciplinary study of user needs for NRT data and products can inform the design and operation of NRT data systems. Follow-on work for this study will also be presented, focusing on the availability of current and future satellite measurements (including NRT) of the 30 most critical Earth observation priorities, as well as a detailed analysis of users' needs for precipitation data. The results of this study summarize the priorities for critical Earth observations utilized globally for societal benefit.

  12. Is Smokeless Tobacco Use an Appropriate Public Health Strategy for Reducing Societal Harm from Cigarette Smoking?

    PubMed Central

    Tomar, Scott L.; Fox, Brion J.; Severson, Herbert H.

    2009-01-01

    Four arguments have been used to support smokeless tobacco (ST) for harm reduction: (1) Switching from cigarettes to ST would reduce health risks; (2) ST is effective for smoking cessation; (3) ST is an effective nicotine maintenance product; and (4) ST is not a “gateway” for cigarette smoking. There is little evidence to support the first three arguments and most evidence suggests that ST is a gateway for cigarette smoking. There are ethical challenges to promoting ST use. Based on the precautionary principle, the burden of proof is on proponents to provide evidence to support their position; such evidence is lacking. PMID:19440266

  13. August 2014 Hiroshima landslide disaster and its societal impact

    NASA Astrophysics Data System (ADS)

    Fukuoka, Hiroshi; Sassa, Kyoji; Wang, Chunxiang

    2015-04-01

    In the early morning of August 20, 2014, Hiroshima city was hit by a number of debris flows along a linear rain band which caused extreme downpour. This disaster claimed 74 death, although this city experienced very similar disaster in 1999, claiming more than 30 residents lives. In the most severely affected debris flow torrent, more than 50 residents were killed. Most of the casualties arose in the wooden, vulnerable houses constructed in front of the exit of torrents. Points and lessons learnt from the disaster are as follows: 1. Extreme rainfall events : geology and geomorphology does not much affect the distribution of landslides initiation sites. 2. Area of causative extreme rainfall is localized in 2 km x 10 km along the rain band. 3. Authors collected two types of sands from the source scar of the initial debris slides which induced debris flows. Tested by the ring shear apparatus under pore-pressure control condition, clear "Sliding surface liquefaction" was confirmed for both samples even under small normal stress, representing the small thickness of the slides. These results shows even instant excess pore pressure could initiate the slides and trigger slide-induced debris flow by undrained loading onto the torrent deposits. 4. Apparently long-term land-use change affected the vulnerability of the community. Residential area had expanded into hill-slope (mountainous / semi-mountainous area) especially along the torrents. Those communities were developed on the past debris flow fan. 5. As the devastated area is very close to downtown of Hiroshima city, it gave gigantic societal impact to the Japanese citizens. After 1999 Hiroshima debris flow disaster, the Landslide disaster reduction law which intends to promote designation of landslide potential risk zones, was adopted in 2000. Immediately after 2014 disaster, national diet approved revision of the bill.

  14. AMISR in the Africa: Scientific and Societal Importance

    NASA Astrophysics Data System (ADS)

    Damtie, B.; Moldwin, M.; Yizengaw, E.; Coster, A. J.; Hysell, D. L.

    2012-12-01

    Much of our understanding of equatorial electrodynamics is primarily based on observations from the Jicamarca incoherent scatter radar (ISR) observatory (JRO), the only ISR in the equatorial region. The JRO is located in the American sector that is characterized by the large off-set in the magnetic to geodectic equators and the shift of the magnetic equator from the southern hemisphere to the northern hemisphere. In the African sector, the geomagnetic and geodetic equators are approximately parallel, separated by at most 10 degrees. Data from satellites (e.g. ROCSAT, C/NOFS, DMSP) have indicated that the equatorial ionosphere in the African sector responds differently than other sectors. For example, ionospheric bubbles have been observed to be much deeper and to occur more frequently in the African sector. It has also been reported that ionospheric depletions more frequently rise to higher altitudes (up to 1000+ km) in the African sector than those in other longitude sectors. However, these observations have not been confirmed, validated or studied in detail by observations from the ground due to lack of suitable ground-based instrumentation in Africa. Thus, the causes or driving mechanisms of the unique density irregularities, bubbles, and depletions in the African sector remain unresolved. To address these issues, the U.S. National Science Foundation recently sponsored a workshop that held at Boston College to consider the possibility of relocating an Advanced Modular Incoherent Scatter Radar (AMISR) to Ethiopia. Adding the ISR to the recently growing number of ground-based space science instruments on the continent, such as GPS, magnetometers, VHF, and Ionosonde, would be of significant scientific benefit and have a huge societal impact on the African space science community in particular and the science and engineering fields in general. The primary purpose of this workshop was to define the science goals motivating such a move and to examine the technical and logistical issues involved. This talk will summarize the findings of this workshop.

  15. Global challenges for e-waste management: the societal implications.

    PubMed

    Magalini, Federico

    2016-03-01

    Over the last decades the electronics industry and ICT Industry in particular has revolutionized the world: electrical and electronic products have become ubiquitous in today's life around the planet. After use, those products are discarded, sometimes after re-use cycles in countries different from those where they were initially sold; becoming what is commonly called e-waste. Compared to other traditional waste streams, e-waste handling poses unique and complex challenges. e-Waste is usually regarded as a waste problem, which can cause environmental damage and severe human health consequences if not safely managed. e-Waste contains significant amounts of toxic and environmentally sensitive materials and is, thus, extremely hazardous to humans and the environment if not properly disposed of or recycled. On the other hand, e-waste is often seen as a potential source of income for individuals and entrepreneurs who aim to recover the valuable materials (metals in particular) contained in discarded equipment. Recently, for a growing number of people, in developing countries in particular, recycling and separation of e-waste has become their main source of income. In most cases, this is done informally, with no or hardly any health and safety standards, exposing workers and the surrounding neighborhoods to extensive health dangers as well as leading to substantial environmental pollution. Treatment processes of e-waste aim to remove the hazardous components and recover as much reusable material (e.g. metals, glass and plastics) as possible; achieving both objectives is most desired. The paper discuss societal implications of proper e-waste management and key elements to be considered in the policy design at country level. PMID:26812759

  16. Critical Infrastructure for Ocean Research and Societal Needs in 2030

    SciTech Connect

    National Research Council

    2011-04-22

    The United States has jurisdiction over 3.4 million square miles of ocean—an expanse greater than the land area of all fifty states combined. This vast marine area offers researchers opportunities to investigate the ocean’s role in an integrated Earth system, but also presents challenges to society, including damaging tsunamis and hurricanes, industrial accidents, and outbreaks of waterborne diseases. The 2010 Gulf of Mexico Deepwater Horizon oil spill and 2011 Japanese earthquake and tsunami are vivid reminders that a broad range of infrastructure is needed to advance our still-incomplete understanding of the ocean. The National Research Council (NRC)’s Ocean Studies Board was asked by the National Science and Technology Council’s Subcommittee on Ocean Science and Technology, comprised of 25 U.S. government agencies, to examine infrastructure needs for ocean research in the year 2030. This request reflects concern, among a myriad of marine issues, over the present state of aging and obsolete infrastructure, insufficient capacity, growing technological gaps, and declining national leadership in marine technological development; issues brought to the nation’s attention in 2004 by the U.S. Commission on Ocean Policy. A 15-member committee of experts identified four themes that encompass 32 future ocean research questions–enabling stewardship of the environment, protecting life and property, promoting economic vitality, and increasing fundamental scientific understanding. Many of the questions in the report (e.g., sea level rise, sustainable fisheries, the global water cycle) reflect challenging, multidisciplinary science questions that are clearly relevant today, and are likely to take decades of effort to solve. As such, U.S. ocean research will require a growing suite of ocean infrastructure for a range of activities, such as high quality, sustained time series observations or autonomous monitoring at a broad range of spatial and temporal scales. Consequently, a coordinated national plan for making future strategic investments becomes an imperative to address societal needs. Such a plan should be based upon known priorities and should be reviewed every 5-10 years to optimize the federal investment. The committee examined the past 20 years of technological advances and ocean infrastructure investments (such as the rise in use of self-propelled, uncrewed, underwater autonomous vehicles), assessed infrastructure that would be required to address future ocean research questions, and characterized ocean infrastructure trends for 2030. One conclusion was that ships will continue to be essential, especially because they provide a platform for enabling other infrastructure – autonomous and remotely operated vehicles; samplers and sensors; moorings and cabled systems; and perhaps most importantly, the human assets of scientists, technical staff, and students. A comprehensive, long-term research fleet plan should be implemented in order to retain access to the sea. The current report also calls for continuing U.S. capability to access fully and partially ice-covered seas; supporting innovation, particularly the development of biogeochemical sensors; enhancing computing and modeling capacity and capability; establishing broadly accessible data management facilities; and increasing interdisciplinary education and promoting a technically-skilled workforce. The committee also provided a framework for prioritizing future investment in ocean infrastructure. They recommend that development, maintenance, or replacement of ocean research infrastructure assets should be prioritized in terms of societal benefit, with particular consideration given to usefulness for addressing important science questions; affordability, efficiency, and longevity; and ability to contribute to other missions or applications. These criteria are the foundation for prioritizing ocean research infrastructure investments by estimating the economic costs and benefits of each potential infrastructure investment, and funding those investments that collectively produce the largest expected net benefit over time. While this type of process is clearly subject to budget constraints, it could quantify the often informal evaluation of linkages between infrastructure, ocean research, the value of information produced, societal objectives, and economic benefits. Addressing the numerous complex science questions facing the entire ocean research enterprise in 2030–from government to academia, industry to nonprofits, local to global scale–represents a major challenge, requiring collaboration across the breadth of the ocean sciences community and nearly seamless coordination between ocean-related federal agencies.

  17. Conditional alignment random fields for multiple motion sequence alignment.

    PubMed

    Kim, Minyoung

    2013-11-01

    We consider the multiple time-series alignment problem, typically focusing on the task of synchronizing multiple motion videos of the same kind of human activity. Finding an optimal global alignment of multiple sequences is infeasible, while there have been several approximate solutions, including iterative pairwise warping algorithms and variants of hidden Markov models. In this paper, we propose a novel probabilistic model that represents the conditional densities of the latent target sequences which are aligned with the given observed sequences through the hidden alignment variables. By imposing certain constraints on the target sequences at the learning stage, we have a sensible model for multiple alignments that can be learned very efficiently by the EM algorithm. Compared to existing methods, our approach yields more accurate alignment while being more robust to local optima and initial configurations. We demonstrate its efficacy on both synthetic and real-world motion videos including facial emotions and human activities. PMID:24051737

  18. Perception of Societal Stigma and Discrimination Towards People Living with HIV/AIDS in Lagos, Nigeria: a Qualitative Study

    PubMed Central

    Olalekan, Adebimpe Wasiu; Akintunde, Akindele Rasaq; Olatunji, Mabayoje Victor

    2014-01-01

    Introduction: The perception of People Living with HIV/AIDS (PLWHAs) on how the public feels about them could influence their willingness to seek medical care, interaction with the society and their coping strategies. Material and methods: This study assessed the perception and behavior of PLWHAs towards societal stigma and discrimination in Lagos, Nigeria. This was a qualitative, descriptive cross sectional study among PLWHAs from three of the three senatorial districts in Lagos State selected using simple random sampling. Six focus group discussions (FGDs), consisting of eight eligible respondents each were held using structured FGD guide. Results: Collected data were analyzed using simple content analysis. About three quarter of all the discussants said life had become miserable following episodes of stigma and discrimination against their personality in public, family, health care settings and the work-place. Some had feelings of guilt and depression towards these actions. About three quarter had coped with the situation by living a low-keyed lifestyle, dissociating themselves from the public and avoiding seeking care in HIV care centers. Majority of respondents were not willing to come out to publicly discuss their positive HIV status for fear of discrimination. Conclusion: Discussants recommended continuous awareness campaigns about HIV to further educate the general public towards reduction of societal stigma and discrimination against PLWHAs. PMID:25126015

  19. Societal output and use of research performed by health research groups

    PubMed Central

    2010-01-01

    The last decade has seen the evaluation of health research pay more and more attention to societal use and benefits of research in addition to scientific quality, both in qualitative and quantitative ways. This paper elaborates primarily on a quantitative approach to assess societal output and use of research performed by health research groups (societal quality of research). For this reason, one of the Dutch university medical centres (i.e. the Leiden University Medical Center (LUMC)) was chosen as the subject of a pilot study, because of its mission to integrate top patient care with medical, biomedical and healthcare research and education. All research departments were used as units of evaluation within this university medical centre. The method consisted of a four-step process to reach a societal quality score per department, based on its (research) outreach to relevant societal stakeholders (the general public, healthcare professionals and the private sector). For each of these three types of stakeholders, indicators within four modes of communication were defined (knowledge production, knowledge exchange, knowledge use and earning capacity). These indicators were measured by a bottom-up approach in a qualitative way (i.e. all departments of the LUMC were asked to list all activities they would consider to be of societal relevance), after which they were converted into quantitative scores. These quantitative scores could then be compared to standardised scientific quality scores that are based on scientific publications and citations of peer-reviewed articles. Based on the LUMC pilot study, only a weak correlation was found between societal and scientific quality. This suggests that societal quality needs additional activities to be performed by health research groups and is not simply the consequence of high scientific quality. Therefore we conclude that scientific and societal evaluation should be considered to be synergistic in terms of learning for the future, accountability and advocacy. This quantitative approach to assess societal quality in a quantitative sense is based on indicators that function as proxies for society quality on different levels, based on the communication of researchers with their societal stakeholders (i.e. knowledge production, knowledge exchange and knowledge use). The methodology presented is just a first attempt to compare scientific quality scores (publication and citation scores) with societal quality scores in a quantitative way. This comparison can be used by organisations (e.g. university medical centres) in their planning and control cycle. PMID:20939915

  20. The debate over food biotechnology in the United States: is a societal consensus achievable?

    PubMed

    Groth, E

    2001-07-01

    Unless the public comes to agree that the benefits of food biotechnology are desirable and the associated risks are acceptable, our society may fail to realize much of the potential benefits. Three historical cases of major technological innovations whose benefits and risks were the subject of heated public controversy are examined, in search of lessons that may suggest a path toward consensus in the biotechnology debate. In each of the cases--water fluoridation, nuclear power and pesticides--proponents of the technology gathered scientific evidence that they believed established that the innovations were safe. In each case, the federal government was heavily involved in oversight, safety regulation, and in the first two cases, active promotion of the technology. Supporters of the technologies employed a variety of communications strategies, ranging from massive "educational" campaigns (e.g. "Our Friend The Atom") to vituperative ad hominem attacks on leading opponents. None of these strategies succeeded in achieving broad societal acceptance of the technologies. Fluoridation today is opposed as vigorously by activist groups as it was when first introduced around 1950; it has not been universally adopted even in the U.S., and it has been rejected in most other countries. The American nuclear power industry is moribund, and the public has essentially rejected the technology. The pesticide industry is thriving, with new generations of products succeeding older more hazardous chemicals in a constant cycle. However, strong regulation has failed to prevent adverse health and ecological effects, which have been empirically associated with pesticide uses after the chemicals were dispersed in the environment. Debate over whether risks of such effects are acceptable has been heated for four decades, with scientists and the public divided. PMID:11506421

  1. GASOLINE: a Cytoscape app for multiple local alignment of PPI networks

    PubMed Central

    Micale, Giovanni; Continella, Andrea; Ferro, Alfredo; Giugno, Rosalba; Pulvirenti, Alfredo

    2014-01-01

    Comparing protein interaction networks can reveal interesting patterns of interactions for a specific function or process in distantly related species. In this paper we present GASOLINE, a Cytoscape app for multiple local alignments of PPI (protein-protein interaction) networks. The app is based on the homonymous greedy and stochastic algorithm. GASOLINE starts with the identification of sets of similar nodes, called seeds of the alignment. Alignments are then extended in a greedy manner and finally refined. Both the identification of seeds and the extension of alignments are performed through an iterative Gibbs sampling strategy. GASOLINE is a Cytoscape app for computing and visualizing local alignments, without requiring any post-processing operations. GO terms can be easily attached to the aligned proteins for further functional analysis of alignments. GASOLINE can perform the alignment task in few minutes, even for a large number of input networks. PMID:25324964

  2. Alignment-Free Design of Highly Discriminatory Diagnostic Primer Sets for Escherichia coli O104:H4 Outbreak Strains

    PubMed Central

    Bielaszewska, Martina; Karch, Helge; Toth, Ian K.

    2012-01-01

    Background An Escherichia coli O104:H4 outbreak in Germany in summer 2011 caused 53 deaths, over 4000 individual infections across Europe, and considerable economic, social and political impact. This outbreak was the first in a position to exploit rapid, benchtop high-throughput sequencing (HTS) technologies and crowdsourced data analysis early in its investigation, establishing a new paradigm for rapid response to disease threats. We describe a novel strategy for design of diagnostic PCR primers that exploited this rapid draft bacterial genome sequencing to distinguish between E. coli O104:H4 outbreak isolates and other pathogenic E. coli isolates, including the historical hæmolytic uræmic syndrome (HUSEC) E. coli HUSEC041 O104:H4 strain, which possesses the same serotype as the outbreak isolates. Methodology/Principal Findings Primers were designed using a novel alignment-free strategy against eleven draft whole genome assemblies of E. coli O104:H4 German outbreak isolates from the E. coli O104:H4 Genome Analysis Crowd-Sourcing Consortium website, and a negative sequence set containing 69 E. coli chromosome and plasmid sequences from public databases. Validation in vitro against 21 ‘positive’ E. coli O104:H4 outbreak and 32 ‘negative’ non-outbreak EHEC isolates indicated that individual primer sets exhibited 100% sensitivity for outbreak isolates, with false positive rates of between 9% and 22%. A minimal combination of two primers discriminated between outbreak and non-outbreak E. coli isolates with 100% sensitivity and 100% specificity. Conclusions/Significance Draft genomes of isolates of disease outbreak bacteria enable high throughput primer design and enhanced diagnostic performance in comparison to traditional molecular assays. Future outbreak investigations will be able to harness HTS rapidly to generate draft genome sequences and diagnostic primer sets, greatly facilitating epidemiology and clinical diagnostics. We expect that high throughput primer design strategies will enable faster, more precise responses to future disease outbreaks of bacterial origin, and help to mitigate their societal impact. PMID:22496820

  3. Robust temporal alignment of multimodal cardiac sequences

    NASA Astrophysics Data System (ADS)

    Perissinotto, Andrea; Queirós, Sandro; Morais, Pedro; Baptista, Maria J.; Monaghan, Mark; Rodrigues, Nuno F.; D'hooge, Jan; Vilaça, João. L.; Barbosa, Daniel

    2015-03-01

    Given the dynamic nature of cardiac function, correct temporal alignment of pre-operative models and intraoperative images is crucial for augmented reality in cardiac image-guided interventions. As such, the current study focuses on the development of an image-based strategy for temporal alignment of multimodal cardiac imaging sequences, such as cine Magnetic Resonance Imaging (MRI) or 3D Ultrasound (US). First, we derive a robust, modality-independent signal from the image sequences, estimated by computing the normalized cross-correlation between each frame in the temporal sequence and the end-diastolic frame. This signal is a resembler for the left-ventricle (LV) volume curve over time, whose variation indicates different temporal landmarks of the cardiac cycle. We then perform the temporal alignment of these surrogate signals derived from MRI and US sequences of the same patient through Dynamic Time Warping (DTW), allowing to synchronize both sequences. The proposed framework was evaluated in 98 patients, which have undergone both 3D+t MRI and US scans. The end-systolic frame could be accurately estimated as the minimum of the image-derived surrogate signal, presenting a relative error of 1.6 +/- 1.9% and 4.0 +/- 4.2% for the MRI and US sequences, respectively, thus supporting its association with key temporal instants of the cardiac cycle. The use of DTW reduces the desynchronization of the cardiac events in MRI and US sequences, allowing to temporally align multimodal cardiac imaging sequences. Overall, a generic, fast and accurate method for temporal synchronization of MRI and US sequences of the same patient was introduced. This approach could be straightforwardly used for the correct temporal alignment of pre-operative MRI information and intra-operative US images.

  4. Nuclear reactor internals alignment configuration

    DOEpatents

    Gilmore, Charles B.; Singleton, Norman R.

    2009-11-10

    An alignment system that employs jacking block assemblies and alignment posts around the periphery of the top plate of a nuclear reactor lower internals core shroud to align an upper core plate with the lower internals and the core shroud with the core barrel. The distal ends of the alignment posts are chamfered and are closely received within notches machined in the upper core plate at spaced locations around the outer circumference of the upper core plate. The jacking block assemblies are used to center the core shroud in the core barrel and the alignment posts assure the proper orientation of the upper core plate. The alignment posts may alternately be formed in the upper core plate and the notches may be formed in top plate.

  5. Lunar Alignments - Identification and Analysis

    NASA Astrophysics Data System (ADS)

    González-García, A. César

    Lunar alignments are difficult to establish given the apparent lack of written accounts clearly pointing toward lunar alignments for individual temples. While some individual cases are reviewed and highlighted, the weight of the proof must fall on statistical sampling. Some definitions for the lunar alignments are provided in order to clarify the targets, and thus, some new tools are provided to try to test the lunar hypothesis in several cases, especially in megalithic astronomy.

  6. Carbon Dioxide Measurements from Space: Scientific Advance and Societal Benefit

    NASA Astrophysics Data System (ADS)

    Boland, S. W.; Duren, R. M.; Miller, C. E.

    2009-04-01

    The dawn of the 21st Century finds spaceborne sensors poised to revolutionize the atmospheric CO2 record by providing high-quality measurements with unprecedented spatio-temporal coverage and density. Space-based CO2 observations will augment local and regional measurements from ground and airborne sensors, providing global context for existing measurements and covering regions not readily accessible or instrumented by other means. Hyperspectral data from the Atmospheric Infrared Sounder (AIRS), launched in 2002, have been used to produce global maps of CO2 concentrations in the mid-troposphere. These data provide important new constraints on the global distribution and transport of CO2. Future satellite missions dedicated to CO2 observations will collect precise global measurements, enabling more detailed process studies and contributing to further improvements in coupled carbon-climate model development, initialization, and validation. Japan's GOSAT mission, scheduled for launch in January 2009 will measure CO2 and CH4 spectral radiances via thermal and near infrared spectrometry to study the transport mechanisms of greenhouse gases with an emphasis on identification of CO2 sources and sinks on sub-continental scales in support of the Kyoto protocol. NASA's Orbiting Carbon Observatory (OCO), scheduled to launch in February 2009, will deliver measurements of column-averaged CO2 dry air mole fraction, XCO2, with the precision, temporal and spatial resolution, and coverage needed to characterize the variability of CO2 sources and sinks on regional spatial scales and seasonal to interannual time scales. Satellite CO2 observations, combined with continued ground and airborne measurements, will improve our understanding of the natural processes and human activities that regulate the atmospheric abundance and distribution of this important greenhouse gas, generating both scientific advance and societal benefit. Deriving actionable information from these observation sources further requires coordinated efforts in carbon-cycle modeling, data assimilation, and data analysis - spanning multiple networks, spatial scales, disciplines, and agencies. A preliminary interdisciplinary planning effort was initiated in 2008 by the authors in concert with representatives of other government agencies, academia, and non-governmental organizations to identify the mechanisms and systems needed to facilitate such end-to-end coordination. In this paper we present a status of this effort, key findings, and future plans.

  7. 4. The transectional structure of society: the basic societal functions.

    PubMed

    2014-05-01

    For the purposes of research and/or evaluation, a society is organised into 13 basic societal functions (BSFs) within an overall Coordination and Control system. This organisation facilitates transectional descriptions of society or a component of a society for assessment at any given time across the longitudinal phases of a disaster. An assessment results in a picture or description of function(s) limited to the point in time of the assessment. Together with simultaneous assessments of the functional status of all, some, or one of the other BSFs, such assessments deliver a transectional picture of the situation of a society. Since no function operates in isolation from the other functions, information of the concomitant status of several BSFs is crucial to gain a better understanding of functional losses and of the effects and side effects of an intervention. The 13 BSFs include: (1) Public Health (dominantly preventive); (2) Medical Care (dominantly curative); (3) Water and Sanitation; (4) Shelter and Clothing; (5) Food and Nutrition; (6) Energy Supplies; (7) Public Works and Engineering; (8) Social Structure; (9) Logistics And Transportation; (10) Security; (11) Communications; (12); Economy; and (13) Education. These BSFs relate with each other through the Coordination and Control function. Many functions of the BSFs and their respective subfunctions and elements overlap (they share some common subfunctions and elements). However, for the purposes of research/evaluation, it is necessary to assign subfunctions and elements to only one of the BSFs. Just as in the practice of clinical medicine, the sum of assessments provides the transectional description of the status of each of these BSFs at a given time. From this information, compared to the pre-event description of the society, interventions are selected that are likely to meet the defined objectives and their overarching goal(s), and respective plans are developed and implemented. The effects of each intervention are evaluated in reference to these goals and objectives and to their eventual effects on other BSFs or subfunctions of a BSF. PMID:24785801

  8. Critical Infrastructure for Ocean Research and Societal Needs in 2030

    NASA Astrophysics Data System (ADS)

    Glickson, D.; Barron, E. J.; Fine, R. A.; Bellingham, J. G.; Boss, E.; Boyle, E. A.; Edwards, M.; Johnson, K. S.; Kelley, D. S.; Kite-Powell, H.; Ramberg, S. E.; Rudnick, D. L.; Schofield, O.; Tamburri, M.; Wiebe, P. H.; Wright, D. J.; Committee on an Ocean Infrastructure StrategyU. S. Ocean Research in 2030

    2011-12-01

    At the request of the Subcommittee on Ocean Science and Technology, an expert committee was convened by the National Research Council to identify major research questions anticipated to be at the forefront of ocean science in 2030, define categories of infrastructure that should be included in planning, provide advice on criteria and processes that could be used to set priorities, and recommend ways to maximize the value of investments in ocean infrastructure. The committee identified 32 future ocean research questions in four themes: enabling stewardship of the environment, protecting life and property, promoting economic vitality, and increasing fundamental scientific understanding. Many of the questions reflect challenging, multidisciplinary science questions that are clearly relevant now and are likely to take decades to solve. U.S. ocean research will require a growing suite of ocean infrastructure for a range of activities, such as high quality, sustained time series observations and autonomous monitoring at a broad range of spatial and temporal scales. A coordinated national plan for making future strategic investments will be needed and should be based upon known priorities and reviewed every 5-10 years. After assessing trends in ocean infrastructure and technology development, the committee recommended implementing a comprehensive, long-term research fleet plan in order to retain access to the sea; continuing U.S. capability to access fully and partially ice-covered seas; supporting innovation, particularly the development of biogeochemical sensors; enhancing computing and modeling capacity and capability; establishing broadly accessible data management facilities; and increasing interdisciplinary education and promoting a technically-skilled workforce. They also recommended that development, maintenance, or replacement of ocean research infrastructure assets should be prioritized in terms of societal benefit. Particular consideration should be given to usefulness for addressing important science questions; affordability, efficiency, and longevity; and ability to contribute to other missions or applications. Estimating the economic costs and benefits of each potential infrastructure investment using these criteria would allow funding of investments that produce the largest expected net benefit over time.

  9. Aligned Defrosting Dunes

    NASA Technical Reports Server (NTRS)

    2004-01-01

    17 August 2004 This July 2004 Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a group of aligned barchan sand dunes in the martian north polar region. At the time, the dunes were covered with seasonal frost, but the frost had begun to sublime away, leaving dark spots and dark outlines around the dunes. The surrounding plains exhibit small, diffuse spots that are also the result of subliming seasonal frost. This northern spring image, acquired on a descending ground track (as MGS was moving north to south on the 'night' side of Mars) is located near 78.8oN, 34.8oW. The image covers an area about 3 km (1.9 mi) across and sunlight illuminates the scene from the upper left.

  10. Societal impacts of regenerative medicine: reflections on the views of orthopedic professionals.

    PubMed

    Niemansburg, Sophie L; Tempels, Tjidde H; Dhert, Wouter J A; van Delden, Johannes J M; Bredenoord, Annelien L

    2015-01-01

    As the amount of clinical studies in orthopedic regenerative medicine (RM) is increasing, it is time to take into account its impact on society. A total of 36 biomedical professionals working at the front row of orthopedic RM were interviewed to explore their attitudes, opinions and expectations regarding the societal impacts of RM. Professionals mainly recognized the societal impacts of counteraction of aging, prevention of disease and social justice. The 'soft' sides of these impacts were hardly mentioned. Whereas they did not perceive themselves in the position to mitigate these impacts, professionals should take up their role as actor and become involved in the societal debate. This is important as they can co-shape the societal impacts during the developmental process of technologies and thereby stimulate responsible innovation. PMID:25562349

  11. Who watches the watchmen? An appraisal of benchmarks for multiple sequence alignment.

    PubMed

    Iantorno, Stefano; Gori, Kevin; Goldman, Nick; Gil, Manuel; Dessimoz, Christophe

    2014-01-01

    Multiple sequence alignment (MSA) is a fundamental and ubiquitous technique in bioinformatics used to infer related residues among biological sequences. Thus alignment accuracy is crucial to a vast range of analyses, often in ways difficult to assess in those analyses. To compare the performance of different aligners and help detect systematic errors in alignments, a number of benchmarking strategies have been pursued. Here we present an overview of the main strategies-based on simulation, consistency, protein structure, and phylogeny-and discuss their different advantages and associated risks. We outline a set of desirable characteristics for effective benchmarking, and evaluate each strategy in light of them. We conclude that there is currently no universally applicable means of benchmarking MSA, and that developers and users of alignment tools should base their choice of benchmark depending on the context of application-with a keen awareness of the assumptions underlying each benchmarking strategy. PMID:24170395

  12. Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis

    PubMed Central

    Nakayama, Karina H.; Hong, Guosong; Lee, Jerry C.; Patel, Jay; Edwards, Bryan; Zaitseva, Tatiana S.; Paukshto, Michael V.; Dai, Hongjie; Cooke, John P.; Woo, Y. Joseph; Huang, Ngan F.

    2016-01-01

    The objective of this study was to enhance the angiogenic capacity of endothelial cells (ECs) using nano-scale signaling cues from aligned nanofibrillar scaffolds in the setting of tissue ischemia. Thread-like nanofibrillar scaffolds with porous structure were fabricated from aligned-braided membranes generated under shear from liquid crystal collagen solution. Human ECs showed greater outgrowth from aligned scaffolds than from non-patterned scaffolds. Integrin ?1 was in part responsible for the enhanced cellular outgrowth on aligned nanofibrillar scaffolds, as the effect was abrogated by integrin ?1 inhibition. To test the efficacy of EC-seeded aligned nanofibrillar scaffolds in improving neovascularization in vivo, the ischemic limbs of mice were treated with: EC-seeded aligned nanofibrillar scaffold; EC-seeded non-patterned scaffold; ECs in saline; aligned nanofibrillar scaffold alone; or no treatment. After 14 days, laser Doppler blood spectroscopy demonstrated significant improvement in blood perfusion recovery when treated with EC-seeded aligned nanofibrillar scaffolds, in comparison to ECs in saline or no treatment. In ischemic hindlimbs treated with scaffolds seeded with human ECs derived from induced pluripotent stem cells (iPSC-ECs), single-walled carbon nanotube (SWNT) fluorophores were systemically delivered to quantify microvascular density after 28 days. Near infrared-II (NIR-II, 1000–1700 nm) imaging of SWNT fluorophores demonstrated that iPSC-EC-seeded aligned scaffolds group showed significantly higher microvascular density than the saline or cells groups. These data suggest that treatment with EC-seeded aligned nanofibrillar scaffolds improved blood perfusion and arteriogenesis, when compared to treatment with cells alone or scaffold alone, and have important implications in the design of therapeutic cell delivery strategies PMID:26061869

  13. Re-alignment of the unmapped reads with base quality score

    PubMed Central

    2015-01-01

    Motivation Based on the next generation genome sequencing technologies, a variety of biological applications are developed, while alignment is the first step once the sequencing reads are obtained. In recent years, many software tools have been developed to efficiently and accurately align short reads to the reference genome. However, there are still many reads that can't be mapped to the reference genome, due to the exceeding of allowable mismatches. Moreover, besides the unmapped reads, the reads with low mapping qualities are also excluded from the downstream analysis, such as variance calling. If we can take advantages of the confident segments of these reads, not only can the alignment rates be improved, but also more information will be provided for the downstream analysis. Results This paper proposes a method, called RAUR (Re-align the Unmapped Reads), to re-align the reads that can not be mapped by alignment tools. Firstly, it takes advantages of the base quality scores (reported by the sequencer) to figure out the most confident and informative segments of the unmapped reads by controlling the number of possible mismatches in the alignment. Then, combined with an alignment tool, RAUR re-align these segments of the reads. We run RAUR on both simulated data and real data with different read lengths. The results show that many reads which fail to be aligned by the most popular alignment tools (BWA and Bowtie2) can be correctly re-aligned by RAUR, with a similar Precision. Even compared with the BWA-MEM and the local mode of Bowtie2, which perform local alignment for long reads to improve the alignment rate, RAUR also shows advantages on the Alignment rate and Precision in some cases. Therefore, the trimming strategy used in RAUR is useful to improve the Alignment rate of alignment tools for the next-generation genome sequencing. Availability All source code are available at http://netlab.csu.edu.cn/bioinformatics/RAUR.html. PMID:25860434

  14. Calibration and Alignment.

    NASA Astrophysics Data System (ADS)

    Grassotti, Christopher; Iskenderian, Haig; Hoffman, Ross N.

    1999-06-01

    Discrepancies between estimates of rainfall from ground-based radar and satellite observing systems can be attributed to either calibration differences or to geolocation and sampling differences. These latter include differences due to radar or satellite misregistration, differences in observation times, or variations in instrument and retrieval algorithm sensitivities. A new methodology has been developed and tested for integrating radar- and satellite-based estimates of precipitation using a feature calibration and alignment (FCA) technique. The parameters describing the calibration and alignment are found using a variational approach, and are composed of displacement and amplitude adjustments to the satellite rainfall retrievals, which minimize the differences with respect to the radar data and satisfy additional smoothness and magnitude constraints. In this approach the amplitude component represents a calibration of the satellite estimate to the radar, whereas the displacement components correct temporal and/or geolocation differences between the radar and satellite data.The method has been tested on a number of cases of the NASA WetNet PIP-2 dataset. These data consist of coincident estimates of rainfall by ground-based radar and the DMSP SSM/I. Sensitivity tests were conducted to tune the parameters of the algorithm. Results indicate the effectiveness of the technique in minimizing the discrepancies between radar and satellite observations of rainfall for a variety of rainfall events ranging from midlatitude frontal precipitation to heavy convection associated with a tropical cyclone (Hurricane Andrew). A remaining issue to be resolved is the incorporation of knowledge about location dependencies in the errors of the radar and microwave estimates.Once the satellite data have been adjusted to match the radar observations, the two independent estimates (radar and adjusted SSM/I rain rates) may be blended to improve the overall depiction of the rainfall event in a single analysis. The FCA technique also has potential applications in 1) the development of satellite rainfall retrieval algorithms that may be tuned to radar rain rates and 2) error assessment of rainfall predictions using radar or satellite rain rates as verification.

  15. Well-pump alignment system

    DOEpatents

    Drumheller, Douglas S. (Cedar Crest, NM)

    1998-01-01

    An improved well-pump for geothermal wells, an alignment system for a well-pump, and to a method for aligning a rotor and stator within a well-pump, wherein the well-pump has a whistle assembly formed at a bottom portion thereof, such that variations in the frequency of the whistle, indicating misalignment, may be monitored during pumping.

  16. Lexical alignment in triadic communication.

    PubMed

    Foltz, Anouschka; Gaspers, Judith; Thiele, Kristina; Stenneken, Prisca; Cimiano, Philipp

    2015-01-01

    Lexical alignment refers to the adoption of one's interlocutor's lexical items. Accounts of the mechanisms underlying such lexical alignment differ (among other aspects) in the role assigned to addressee-centered behavior. In this study, we used a triadic communicative situation to test which factors may modulate the extent to which participants' lexical alignment reflects addressee-centered behavior. Pairs of naïve participants played a picture matching game and received information about the order in which pictures were to be matched from a voice over headphones. On critical trials, participants did or did not hear a name for the picture to be matched next over headphones. Importantly, when the voice over headphones provided a name, it did not match the name that the interlocutor had previously used to describe the object. Participants overwhelmingly used the word that the voice over headphones provided. This result points to non-addressee-centered behavior and is discussed in terms of disrupting alignment with the interlocutor as well as in terms of establishing alignment with the voice over headphones. In addition, the type of picture (line drawing vs. tangram shape) independently modulated lexical alignment, such that participants showed more lexical alignment to their interlocutor for (more ambiguous) tangram shapes compared to line drawings. Overall, the results point to a rather large role for non-addressee-centered behavior during lexical alignment. PMID:25762955

  17. Lexical alignment in triadic communication

    PubMed Central

    Foltz, Anouschka; Gaspers, Judith; Thiele, Kristina; Stenneken, Prisca; Cimiano, Philipp

    2015-01-01

    Lexical alignment refers to the adoption of one’s interlocutor’s lexical items. Accounts of the mechanisms underlying such lexical alignment differ (among other aspects) in the role assigned to addressee-centered behavior. In this study, we used a triadic communicative situation to test which factors may modulate the extent to which participants’ lexical alignment reflects addressee-centered behavior. Pairs of naïve participants played a picture matching game and received information about the order in which pictures were to be matched from a voice over headphones. On critical trials, participants did or did not hear a name for the picture to be matched next over headphones. Importantly, when the voice over headphones provided a name, it did not match the name that the interlocutor had previously used to describe the object. Participants overwhelmingly used the word that the voice over headphones provided. This result points to non-addressee-centered behavior and is discussed in terms of disrupting alignment with the interlocutor as well as in terms of establishing alignment with the voice over headphones. In addition, the type of picture (line drawing vs. tangram shape) independently modulated lexical alignment, such that participants showed more lexical alignment to their interlocutor for (more ambiguous) tangram shapes compared to line drawings. Overall, the results point to a rather large role for non-addressee-centered behavior during lexical alignment. PMID:25762955

  18. On the alignment of quasars

    NASA Astrophysics Data System (ADS)

    Zhu, Xing-fen

    1986-06-01

    Taking the two Savage-Bolton 5° × 5° regions of optical quasar patrol as samples, I made a systematic analysis of the number of aligned quasars and compared with the random data generated by Monte Carlo method. The statistical result is that, at least for these two samples, there is no clear evidence for alignment.

  19. On the alignment of quasars

    NASA Astrophysics Data System (ADS)

    Zhu, X.-F.

    1986-06-01

    Taking the two Savage-Bolton 5 deg x 5 deg regions of optical quasar patrol as samples, a systematic analysis of the number of aligned quasars was made and compared with the random data generated by Monte Carlo method. The statistical result is that, at least for these two samples, there is no clear evidence for alignment.

  20. Drive alignment pays maintenance dividends

    SciTech Connect

    Fedder, R.

    2008-12-15

    Proper alignment of the motor and gear drive on conveying and processing equipment will result in longer bearing and coupling life, along with lower maintenance costs. Selecting an alignment free drive package instead of a traditional foot mounted drive and motor is a major advancement toward these goals. 4 photos.

  1. Reconciling societal and scientific definitions for the monsoon

    NASA Astrophysics Data System (ADS)

    Reeve, Mathew; Stephenson, David

    2014-05-01

    Science defines the monsoon in numerous ways. We can apply these definitions to forecast data, reanalysis data, observations, GCMs and more. In a basic research setting, we hope that this work will advance science and our understanding of the monsoon system. In an applied research setting, we often hope that this work will benefit a specific stakeholder or community. We may want to inform a stakeholder when the monsoon starts, now and in the future. However, what happens if the stakeholders cannot relate to the information because their perceptions do not align with the monsoon definition we use in our analysis? We can resolve this either by teaching the stakeholders or learning from them about how they define the monsoon and when they perceive it to begin. In this work we reconcile different scientific monsoon definitions with the perceptions of agricultural communities in Bangladesh. We have developed a statistical technique that rates different scientific definitions against the people's perceptions of when the monsoon starts and ends. We construct a probability mass function (pmf) around each of the respondent's answers in a questionnaire survey. We can use this pmf to analyze the time series of monsoon onsets and withdrawals from the different scientific definitions. We can thereby quantitatively judge which definition may be most appropriate for a specific applied research setting.

  2. Magnetic Alignment of Block Copolymer Microdomains by Intrinsic Chain Anisotropy

    NASA Astrophysics Data System (ADS)

    Rokhlenko, Yekaterina; Gopinadhan, Manesh; Osuji, Chinedum O.; Zhang, Kai; O'Hern, Corey S.; Larson, Steven R.; Gopalan, Padma; Majewski, Paweł W.; Yager, Kevin G.

    2015-12-01

    We examine the role of intrinsic chain susceptibility anisotropy in magnetic field directed self-assembly of a block copolymer using in situ x-ray scattering. Alignment of a lamellar mesophase is observed on cooling across the disorder-order transition with the resulting orientational order inversely proportional to the cooling rate. We discuss the origin of the susceptibility anisotropy, Δ χ , that drives alignment and calculate its magnitude using coarse-grained molecular dynamics to sample conformations of surface-tethered chains, finding Δ χ ≈2 ×1 0-8. From field-dependent scattering data, we estimate that grains of ≈1.2 μ m are present during alignment. These results demonstrate that intrinsic anisotropy is sufficient to support strong field-induced mesophase alignment and suggest a versatile strategy for field control of orientational order in block copolymers.

  3. Magnetic Alignment of Block Copolymer Microdomains by Intrinsic Chain Anisotropy.

    PubMed

    Rokhlenko, Yekaterina; Gopinadhan, Manesh; Osuji, Chinedum O; Zhang, Kai; O'Hern, Corey S; Larson, Steven R; Gopalan, Padma; Majewski, Paweł W; Yager, Kevin G

    2015-12-18

    We examine the role of intrinsic chain susceptibility anisotropy in magnetic field directed self-assembly of a block copolymer using in situ x-ray scattering. Alignment of a lamellar mesophase is observed on cooling across the disorder-order transition with the resulting orientational order inversely proportional to the cooling rate. We discuss the origin of the susceptibility anisotropy, Δχ, that drives alignment and calculate its magnitude using coarse-grained molecular dynamics to sample conformations of surface-tethered chains, finding Δχ≈2×10^{-8}. From field-dependent scattering data, we estimate that grains of ≈1.2  μm are present during alignment. These results demonstrate that intrinsic anisotropy is sufficient to support strong field-induced mesophase alignment and suggest a versatile strategy for field control of orientational order in block copolymers. PMID:26722950

  4. Stellar Alignments - Identification and Analysis

    NASA Astrophysics Data System (ADS)

    Ruggles, Clive L. N.

    Fortuitous stellar alignments can be fitted to structural orientations with relative ease by the unwary. Nonetheless, cautious approaches taking into account a broader range of cultural evidence, as well as paying due attention to potential methodological pitfalls, have been successful in identifying credible stellar alignments—and constructing plausible assessments of their cultural significance—in a variety of circumstances. These range from single instances of alignments upon particular asterisms where the corroborating historical or ethnographic evidence is strong to repeated instances of oriented structures with only limited independent cultural information but where systematic, data-driven approaches can be productive. In the majority of cases, the identification and interpretation of putative stellar alignments relates to groups of similar monuments or complex single sites and involves a balance between systematic studies of the alignments themselves, backed up by statistical analysis where appropriate, and the consideration of a range of contextual evidence, either derived from the archaeological record alone or from other relevant sources.

  5. Alignment of the MINOS FD

    SciTech Connect

    Becker, B.; Boehnlein, D.; /Fermilab

    2004-11-01

    The results and procedure of the alignment of the MINOS Far Detector are presented. The far detector has independent alignments of SM1 and SM2. The misalignments have an estimated uncertainty of {approx}850 {micro}m for SM1 and {approx}750 {micro}m for SM2. The alignment has as inputs the average rotations of U and V as determined by optical survey and strip positions within modules measured from the module mapper. The output of this is a module-module correction for transverse mis-alignments. These results were verified by examining an independent set of data. These alignment constants on average contribute much less then 1% to the total uncertainty in the transverse strip position.

  6. Alignment-Annotator web server: rendering and annotating sequence alignments

    PubMed Central

    Gille, Christoph; Fähling, Michael; Weyand, Birgit; Wieland, Thomas; Gille, Andreas

    2014-01-01

    Alignment-Annotator is a novel web service designed to generate interactive views of annotated nucleotide and amino acid sequence alignments (i) de novo and (ii) embedded in other software. All computations are performed at server side. Interactivity is implemented in HTML5, a language native to web browsers. The alignment is initially displayed using default settings and can be modified with the graphical user interfaces. For example, individual sequences can be reordered or deleted using drag and drop, amino acid color code schemes can be applied and annotations can be added. Annotations can be made manually or imported (BioDAS servers, the UniProt, the Catalytic Site Atlas and the PDB). Some edits take immediate effect while others require server interaction and may take a few seconds to execute. The final alignment document can be downloaded as a zip-archive containing the HTML files. Because of the use of HTML the resulting interactive alignment can be viewed on any platform including Windows, Mac OS X, Linux, Android and iOS in any standard web browser. Importantly, no plugins nor Java are required and therefore Alignment-Anotator represents the first interactive browser-based alignment visualization. Availability: http://www.bioinformatics.org/strap/aa/ and http://strap.charite.de/aa/. PMID:24813445

  7. Space Mirror Alignment System

    NASA Technical Reports Server (NTRS)

    Jau, Bruno M.; McKinney, Colin; Smythe, Robert F.; Palmer, Dean L.

    2011-01-01

    An optical alignment mirror mechanism (AMM) has been developed with angular positioning accuracy of +/-0.2 arcsec. This requires the mirror s linear positioning actuators to have positioning resolutions of +/-112 nm to enable the mirror to meet the angular tip/tilt accuracy requirement. Demonstrated capabilities are 0.1 arc-sec angular mirror positioning accuracy, which translates into linear positioning resolutions at the actuator of 50 nm. The mechanism consists of a structure with sets of cross-directional flexures that enable the mirror s tip and tilt motion, a mirror with its kinematic mount, and two linear actuators. An actuator comprises a brushless DC motor, a linear ball screw, and a piezoelectric brake that holds the mirror s position while the unit is unpowered. An interferometric linear position sensor senses the actuator s position. The AMMs were developed for an Astrometric Beam Combiner (ABC) optical bench, which is part of an interferometer development. Custom electronics were also developed to accommodate the presence of multiple AMMs within the ABC and provide a compact, all-in-one solution to power and control the AMMs.

  8. Alignment positioning mechanism

    NASA Technical Reports Server (NTRS)

    Fantasia, Peter M. (inventor)

    1991-01-01

    An alignment positioning mechanism for correcting and compensating for misalignment of structures to be coupled is disclosed. The mechanism comprises a power screw with a base portion and a threaded shank portion. A mounting fixture is provided for rigidly coupling said base portion to the mounting interface of a supporting structure with the axis of the screw perpendicular thereto. A traveling ball nut threaded on the power screw is formed with an external annular arcuate surface configured in the form of a spherical segment and enclosed by a ball nut housing with a conforming arcuate surface for permitting gimballed motion thereon. The ball nut housing is provided with a mounting surface which is positionable in cooperable engagement with the mounting interface of a primary structure to be coupled to the supporting structure. Cooperative means are provided on the ball nut and ball nut housing, respectively, for positioning the ball nut and ball nut housing in relative gimballed position within a predetermined range of relative angular relationship whereby severe structural stresses due to unequal loadings and undesirable bending moments on the mechanism are avoided.

  9. Grid alignment in entorhinal cortex.

    PubMed

    Si, Bailu; Kropff, Emilio; Treves, Alessandro

    2012-10-01

    The spatial responses of many of the cells recorded in all layers of rodent medial entorhinal cortex (mEC) show mutually aligned grid patterns. Recent experimental findings have shown that grids can often be better described as elliptical rather than purely circular and that, beyond the mutual alignment of their grid axes, ellipses tend to also orient their long axis along preferred directions. Are grid alignment and ellipse orientation aspects of the same phenomenon? Does the grid alignment result from single-unit mechanisms or does it require network interactions? We address these issues by refining a single-unit adaptation model of grid formation, to describe specifically the spontaneous emergence of conjunctive grid-by-head-direction cells in layers III, V, and VI of mEC. We find that tight alignment can be produced by recurrent collateral interactions, but this requires head-direction (HD) modulation. Through a competitive learning process driven by spatial inputs, grid fields then form already aligned, and with randomly distributed spatial phases. In addition, we find that the self-organization process is influenced by any anisotropy in the behavior of the simulated rat. The common grid alignment often orients along preferred running directions (RDs), as induced in a square environment. When speed anisotropy is present in exploration behavior, the shape of individual grids is distorted toward an ellipsoid arrangement. Speed anisotropy orients the long ellipse axis along the fast direction. Speed anisotropy on its own also tends to align grids, even without collaterals, but the alignment is seen to be loose. Finally, the alignment of spatial grid fields in multiple environments shows that the network expresses the same set of grid fields across environments, modulo a coherent rotation and translation. Thus, an efficient metric encoding of space may emerge through spontaneous pattern formation at the single-unit level, but it is coherent, hence context-invariant, if aided by collateral interactions. PMID:22892761

  10. Testing the tidal alignment model of galaxy intrinsic alignment

    SciTech Connect

    Blazek, Jonathan; Seljak, Uroš; McQuinn, Matthew E-mail: mmcquinn@berkeley.edu

    2011-05-01

    Weak gravitational lensing has become a powerful probe of large-scale structure and cosmological parameters. Precision weak lensing measurements require an understanding of the intrinsic alignment of galaxy ellipticities, which can in turn inform models of galaxy formation. It is hypothesized that elliptical galaxies align with the background tidal field and that this alignment mechanism dominates the correlation between ellipticities on cosmological scales (in the absence of lensing). We use recent large-scale structure measurements from the Sloan Digital Sky Survey to test this picture with several statistics: (1) the correlation between ellipticity and galaxy overdensity, w{sub g+}; (2) the intrinsic alignment auto-correlation functions; (3) the correlation functions of curl-free, E, and divergence-free, B, modes, the latter of which is zero in the linear tidal alignment theory; (4) the alignment correlation function, w{sub g}(r{sub p},θ), a recently developed statistic that generalizes the galaxy correlation function to account for the angle between the galaxy separation vector and the principle axis of ellipticity. We show that recent measurements are largely consistent with the tidal alignment model and discuss dependence on galaxy luminosity. In addition, we show that at linear order the tidal alignment model predicts that the angular dependence of w{sub g}(r{sub p},θ) is simply w{sub g+}(r{sub p})cos (2θ) and that this dependence is consistent with recent measurements. We also study how stochastic nonlinear contributions to galaxy ellipticity impact these statistics. We find that a significant fraction of the observed LRG ellipticity can be explained by alignment with the tidal field on scales ∼> 10 \\hMpc. These considerations are relevant to galaxy formation and evolution.

  11. Extreme Weather Events on the Last Frontier: Meteorological Analyses and Societal Impacts

    NASA Astrophysics Data System (ADS)

    Zuromski, L.; Walsh, J. E.; Thoman, R.

    2014-12-01

    The National Weather Service lacks a comprehensive compilation of major weather events in Alaska. Creating a repository of the effects of past storms and other extreme weather events on society, together with documentation of the meteorological evolution of the events, will facilitate the NWS and other government agencies to analyze this data. Such analysis will improve their strategies, such as sharpening local and state responses to extreme weather and enhancing forecasts for the events, to create a more weather-ready society in Alaska. This research examines six high-impact weather events in Alaska, ranging in dates from 1974 until 2012. Atmospheric data was gathered from the Earth System Research Laboratory (ESRL)'s 6-Hour National Centers for Environmental Prediction (NCEP) and National Center for Atmospheric Research (NCAR) Data Reanalysis Composites and from 3-Hour NCEP North American Regional Reanalysis (NARR) Composites. Reanalysis composites of sea-level pressure, temperature, geopotential height, and vector wind allowed for the storms to be tracked and for weather pattern anomalies to be recognized. Societal impacts were investigated by using the National Climactic Data Center (NCDC)'s online Storm Events Database and by utilizing microfilms of Alaskan newspapers detailing the events. Synthesizing facts from NCDC and newspapers, along with incorporating meteorological knowledge from the atmospheric reanalysis composites, summaries of the events could then be created. In the future, this research will be continued to include a broader range of high-impact Alaskan weather events. This work will further serve as a basis for analysis for decision-makers to better plan for extreme events and their aftermath. The completed research, though a small portion of the anticipated project, provides a template for future data assimilation, and it initiates the efforts towards a more weather-prepared Alaska.

  12. Automated whole-genome multiple alignment of rat, mouse, and human

    SciTech Connect

    Brudno, Michael; Poliakov, Alexander; Salamov, Asaf; Cooper, Gregory M.; Sidow, Arend; Rubin, Edward M.; Solovyev, Victor; Batzoglou, Serafim; Dubchak, Inna

    2004-07-04

    We have built a whole genome multiple alignment of the three currently available mammalian genomes using a fully automated pipeline which combines the local/global approach of the Berkeley Genome Pipeline and the LAGAN program. The strategy is based on progressive alignment, and consists of two main steps: (1) alignment of the mouse and rat genomes; and (2) alignment of human to either the mouse-rat alignments from step 1, or the remaining unaligned mouse and rat sequences. The resulting alignments demonstrate high sensitivity, with 87% of all human gene-coding areas aligned in both mouse and rat. The specificity is also high: <7% of the rat contigs are aligned to multiple places in human and 97% of all alignments with human sequence > 100kb agree with a three-way synteny map built independently using predicted exons in the three genomes. At the nucleotide level <1% of the rat nucleotides are mapped to multiple places in the human sequence in the alignment; and 96.5% of human nucleotides within all alignments agree with the synteny map. The alignments are publicly available online, with visualization through the novel Multi-VISTA browser that we also present.

  13. Galaxy Alignments: Theory, Modelling & Simulations

    NASA Astrophysics Data System (ADS)

    Kiessling, Alina; Cacciato, Marcello; Joachimi, Benjamin; Kirk, Donnacha; Kitching, Thomas D.; Leonard, Adrienne; Mandelbaum, Rachel; Schäfer, Björn Malte; Sifón, Cristóbal; Brown, Michael L.; Rassat, Anais

    2015-11-01

    The shapes of galaxies are not randomly oriented on the sky. During the galaxy formation and evolution process, environment has a strong influence, as tidal gravitational fields in the large-scale structure tend to align nearby galaxies. Additionally, events such as galaxy mergers affect the relative alignments of both the shapes and angular momenta of galaxies throughout their history. These "intrinsic galaxy alignments" are known to exist, but are still poorly understood. This review will offer a pedagogical introduction to the current theories that describe intrinsic galaxy alignments, including the apparent difference in intrinsic alignment between early- and late-type galaxies and the latest efforts to model them analytically. It will then describe the ongoing efforts to simulate intrinsic alignments using both N-body and hydrodynamic simulations. Due to the relative youth of this field, there is still much to be done to understand intrinsic galaxy alignments and this review summarises the current state of the field, providing a solid basis for future work.

  14. BAYESIAN PROTEIN STRUCTURE ALIGNMENT1

    PubMed Central

    RODRIGUEZ, ABEL; SCHMIDLER, SCOTT C.

    2015-01-01

    The analysis of the three-dimensional structure of proteins is an important topic in molecular biochemistry. Structure plays a critical role in defining the function of proteins and is more strongly conserved than amino acid sequence over evolutionary timescales. A key challenge is the identification and evaluation of structural similarity between proteins; such analysis can aid in understanding the role of newly discovered proteins and help elucidate evolutionary relationships between organisms. Computational biologists have developed many clever algorithmic techniques for comparing protein structures, however, all are based on heuristic optimization criteria, making statistical interpretation somewhat difficult. Here we present a fully probabilistic framework for pairwise structural alignment of proteins. Our approach has several advantages, including the ability to capture alignment uncertainty and to estimate key “gap” parameters which critically affect the quality of the alignment. We show that several existing alignment methods arise as maximum a posteriori estimates under specific choices of prior distributions and error models. Our probabilistic framework is also easily extended to incorporate additional information, which we demonstrate by including primary sequence information to generate simultaneous sequence–structure alignments that can resolve ambiguities obtained using structure alone. This combined model also provides a natural approach for the difficult task of estimating evolutionary distance based on structural alignments. The model is illustrated by comparison with well-established methods on several challenging protein alignment examples.

  15. Sequence Alignment as Hypothesis Testing

    PubMed Central

    Meng, Lu; Sun, Fengzhu; Zhang, Xuegong

    2011-01-01

    Abstract Sequence alignment depends on the scoring function that defines similarity between pairs of letters. For local alignment, the computational algorithm searches for the most similar segments in the sequences according to the scoring function. The choice of this scoring function is important for correctly detecting segments of interest. We formulate sequence alignment as a hypothesis testing problem, and conduct extensive simulation experiments to study the relationship between the scoring function and the distribution of aligned pairs within the aligned segment under this framework. We cut through the many ways to construct scoring functions and showed that any scoring function with negative expectation used in local alignment corresponds to a hypothesis test between the background distribution of sequence letters and a statistical distribution of letter pairs determined by the scoring function. The results indicate that the log-likelihood ratio scoring function is statistically most powerful and has the highest accuracy for detecting the segments of interest that are defined by the statistical distribution of aligned letter pairs. PMID:21554016

  16. Advanced Mask Aligner Lithography (AMALITH)

    NASA Astrophysics Data System (ADS)

    Voelkel, Reinhard; Vogler, Uwe; Bramati, Arianna

    2015-03-01

    Mask aligner lithography is very attractive for less-critical lithography layers and is widely used for LED, display, CMOS image sensor, micro-fluidics and MEMS manufacturing. Mask aligner lithography is also a preferred choice the semiconductor back-end for 3D-IC, TSV interconnects, advanced packaging (AdP) and wafer-level-packaging (WLP). Mask aligner lithography is a mature technique based on shadow printing and has not much changed since the 1980s. In shadow printing lithography a geometric pattern is transferred by free-space propagation from a photomask to a photosensitive layer on a wafer. The inherent simplicity of the pattern transfer offers ease of operation, low maintenance, moderate capital expenditure, high wafers-per-hour (WPH) throughput, and attractive cost-of-ownership (COO). Advanced mask aligner lithography (AMALITH) comprises different measures to improve shadow printing lithography beyond current limits. The key enabling technology for AMALITH is a novel light integrator systems, referred to as MO Exposure Optics® (MOEO). MOEO allows to fully control and shape the properties of the illumination light in a mask aligner. Full control is the base for accurate simulation and optimization of the shadow printing process (computational lithography). Now photolithography enhancement techniques like customized illumination, optical proximity correction (OPC), phase masks (AAPSM), half-tone lithography and Talbot lithography could be used in mask aligner lithography. We summarize the recent progress in advanced mask aligner lithography (AMALITH) and discuss possible measures to further improve shadow printing lithography.

  17. A rank-based sequence aligner with applications in phylogenetic analysis.

    PubMed

    Dinu, Liviu P; Ionescu, Radu Tudor; Tomescu, Alexandru I

    2014-01-01

    Recent tools for aligning short DNA reads have been designed to optimize the trade-off between correctness and speed. This paper introduces a method for assigning a set of short DNA reads to a reference genome, under Local Rank Distance (LRD). The rank-based aligner proposed in this work aims to improve correctness over speed. However, some indexing strategies to speed up the aligner are also investigated. The LRD aligner is improved in terms of speed by storing [Formula: see text]-mer positions in a hash table for each read. Another improvement, that produces an approximate LRD aligner, is to consider only the positions in the reference that are likely to represent a good positional match of the read. The proposed aligner is evaluated and compared to other state of the art alignment tools in several experiments. A set of experiments are conducted to determine the precision and the recall of the proposed aligner, in the presence of contaminated reads. In another set of experiments, the proposed aligner is used to find the order, the family, or the species of a new (or unknown) organism, given only a set of short Next-Generation Sequencing DNA reads. The empirical results show that the aligner proposed in this work is highly accurate from a biological point of view. Compared to the other evaluated tools, the LRD aligner has the important advantage of being very accurate even for a very low base coverage. Thus, the LRD aligner can be considered as a good alternative to standard alignment tools, especially when the accuracy of the aligner is of high importance. Source code and UNIX binaries of the aligner are freely available for future development and use at http://lrd.herokuapp.com/aligners. The software is implemented in C++ and Java, being supported on UNIX and MS Windows. PMID:25133391

  18. A Rank-Based Sequence Aligner with Applications in Phylogenetic Analysis

    PubMed Central

    2014-01-01

    Recent tools for aligning short DNA reads have been designed to optimize the trade-off between correctness and speed. This paper introduces a method for assigning a set of short DNA reads to a reference genome, under Local Rank Distance (LRD). The rank-based aligner proposed in this work aims to improve correctness over speed. However, some indexing strategies to speed up the aligner are also investigated. The LRD aligner is improved in terms of speed by storing -mer positions in a hash table for each read. Another improvement, that produces an approximate LRD aligner, is to consider only the positions in the reference that are likely to represent a good positional match of the read. The proposed aligner is evaluated and compared to other state of the art alignment tools in several experiments. A set of experiments are conducted to determine the precision and the recall of the proposed aligner, in the presence of contaminated reads. In another set of experiments, the proposed aligner is used to find the order, the family, or the species of a new (or unknown) organism, given only a set of short Next-Generation Sequencing DNA reads. The empirical results show that the aligner proposed in this work is highly accurate from a biological point of view. Compared to the other evaluated tools, the LRD aligner has the important advantage of being very accurate even for a very low base coverage. Thus, the LRD aligner can be considered as a good alternative to standard alignment tools, especially when the accuracy of the aligner is of high importance. Source code and UNIX binaries of the aligner are freely available for future development and use at http://lrd.herokuapp.com/aligners. The software is implemented in C++ and Java, being supported on UNIX and MS Windows. PMID:25133391

  19. Going Mobile: Perspectives on Aligning Learning and Teaching in Geography

    ERIC Educational Resources Information Center

    Jarvis, Claire H.; Dickie, Jennifer; Brown, Gavin

    2013-01-01

    There has been little consideration to date regarding how we might best adjust our assessment protocols so that the overall learning experience remains appropriately aligned to both content and teaching approach when adopting location-specific mobile learning. This paper explores the success of a novel strategy to design an assessment regime that…

  20. Fusion bonding and alignment fixture

    DOEpatents

    Ackler, Harold D. (Sunnyvale, CA); Swierkowski, Stefan P. (Livermore, CA); Tarte, Lisa A. (Livermore, CA); Hicks, Randall K. (Stockton, CA)

    2000-01-01

    An improved vacuum fusion bonding structure and process for aligned bonding of large area glass plates, patterned with microchannels and access holes and slots, for elevated glass fusion temperatures. Vacuum pumpout of all the components is through the bottom platform which yields an untouched, defect free top surface which greatly improves optical access through this smooth surface. Also, a completely non-adherent interlayer, such as graphite, with alignment and location features is located between the main steel platform and the glass plate pair, which makes large improvements in quality, yield, and ease of use, and enables aligned bonding of very large glass structures.

  1. The how and why of societal publications for citizen science projects and scientists

    NASA Astrophysics Data System (ADS)

    van Vliet, Arnold J. H.; Bron, Wichertje A.; Mulder, Sara

    2014-05-01

    In the scientific community, the importance of communication to society is often underestimated. Scientists and scientific organisations often lack the skills to organise such communication effectively. The Dutch citizen science phenology network Nature's Calendar has been successful in communicating to the general public via numerous newspaper articles, television appearances, presentations, websites and social media. We refer to these publications as societal publications. Due to active communication to mass media, we frequently reach millions of people. This communication helped us to involve thousands of volunteers in recording the timing of phenological events like the start of flowering, leaf unfolding and bird migration, but also several health-related events like hay fever symptoms and tick bites. In this paper, we analyse and present our experiences with the Nature's Calendar project regarding societal publications. Based on this analysis, we explain the importance of societal publications for citizen science projects and scientists in general, and we show how scientists can increase the newsworthiness of scientific information and what factors and activities can increase the chances of media paying attention to this news. We show that societal publications help phenological networks by facilitating the recruitment, retention and instruction of observers. Furthermore, they stimulate the generation of new ideas and partners that lead to an increase in knowledge, awareness and behavioural change of the general public or specific stakeholders. They make projects, and scientists involved, better known to the public and increase their credibility and authority. Societal publications can catalyse the production of new publications, thereby enforcing the previous mentioned points.

  2. Laser beam alignment apparatus and method

    DOEpatents

    Gruhn, Charles R. (Martinez, CA); Hammond, Robert B. (Los Alamos, NM)

    1981-01-01

    The disclosure relates to an apparatus and method for laser beam alignment. Thermoelectric properties of a disc in a laser beam path are used to provide an indication of beam alignment and/or automatic laser alignment.

  3. Theory of grain alignment in molecular clouds

    NASA Technical Reports Server (NTRS)

    Roberge, Wayne G.

    1993-01-01

    Research accomplishments are presented and include the following: (1) mathematical theory of grain alignment; (2) super-paramagnetic alignment of molecular cloud grains; and (3) theory of grain alignment by ambipolar diffusion.

  4. Fixture for aligning motor assembly

    SciTech Connect

    Shervington, Roger M.; Vaghani, Vallabh V.; Vanek, Laurence D.; Christensen, Scott A.

    2009-12-08

    An alignment fixture includes a rotor fixture, a stator fixture and a sensor system which measures a rotational displacement therebetween. The fixture precisely measures rotation of a generator stator assembly away from a NULL position referenced by a unique reference spline on the rotor shaft. By providing an adjustable location of the stator assembly within the housing, the magnetic axes within each generator shall be aligned to a predetermined and controlled tolerance between the generator interface mounting pin and the reference spline on the rotor shaft. Once magnetically aligned, each generator is essentially a line replaceable unit which may be readily mounted to any input of a multi-generator gearbox assembly with the assurance that the magnetic alignment will be within a predetermined tolerance.

  5. Geological mapping goes 3-D in response to societal needs

    USGS Publications Warehouse

    Thorleifson, H.; Berg, R.C.; Russell, H.A.J.

    2010-01-01

    The transition to 3-D mapping has been made possible by technological advances in digital cartography, GIS, data storage, analysis, and visualization. Despite various challenges, technological advancements facilitated a gradual transition from 2-D maps to 2.5-D draped maps to 3-D geological mapping, supported by digital spatial and relational databases that can be interrogated horizontally or vertically and viewed interactively. Challenges associated with data collection, human resources, and information management are daunting due to their resource and training requirements. The exchange of strategies at the workshops has highlighted the use of basin analysis to develop a process-based predictive knowledge framework that facilitates data integration. Three-dimensional geological information meets a public demand that fills in the blanks left by conventional 2-D mapping. Two-dimensional mapping will, however, remain the standard method for extensive areas of complex geology, particularly where deformed igneous and metamorphic rocks defy attempts at 3-D depiction.

  6. Major osteoporotic fragility fractures: Risk factor updates and societal impact.

    PubMed

    Pisani, Paola; Renna, Maria Daniela; Conversano, Francesco; Casciaro, Ernesto; Di Paola, Marco; Quarta, Eugenio; Muratore, Maurizio; Casciaro, Sergio

    2016-03-18

    Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a major public health burden, by means of both social cost and health condition of the elderly because these fractures are one of the main causes of morbidity, impairment, decreased quality of life and mortality in women and men. The aim of this review is to analyze the most important factors related to the enormous impact of osteoporotic fractures on population. Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders (for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associated with augmented risk of fragility fracture. The increasing trend of osteoporosis is accompanied by an underutilization of the available preventive strategies and only a small number of patients at high fracture risk are recognized and successively referred for therapy. This report provides analytic evidences to assess the best practices in osteoporosis management and indications for the adoption of a correct healthcare strategy to significantly reduce the osteoporosis burden. Early diagnosis is the key to resize the impact of osteoporosis on healthcare system. In this context, attention must be focused on the identification of high fracture risk among osteoporotic patients. It is necessary to increase national awareness campaigns across countries in order to reduce the osteoporotic fractures incidence. PMID:27004165

  7. Major osteoporotic fragility fractures: Risk factor updates and societal impact

    PubMed Central

    Pisani, Paola; Renna, Maria Daniela; Conversano, Francesco; Casciaro, Ernesto; Di Paola, Marco; Quarta, Eugenio; Muratore, Maurizio; Casciaro, Sergio

    2016-01-01

    Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a major public health burden, by means of both social cost and health condition of the elderly because these fractures are one of the main causes of morbidity, impairment, decreased quality of life and mortality in women and men. The aim of this review is to analyze the most important factors related to the enormous impact of osteoporotic fractures on population. Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders (for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associated with augmented risk of fragility fracture. The increasing trend of osteoporosis is accompanied by an underutilization of the available preventive strategies and only a small number of patients at high fracture risk are recognized and successively referred for therapy. This report provides analytic evidences to assess the best practices in osteoporosis management and indications for the adoption of a correct healthcare strategy to significantly reduce the osteoporosis burden. Early diagnosis is the key to resize the impact of osteoporosis on healthcare system. In this context, attention must be focused on the identification of high fracture risk among osteoporotic patients. It is necessary to increase national awareness campaigns across countries in order to reduce the osteoporotic fractures incidence. PMID:27004165

  8. Well-pump alignment system

    DOEpatents

    Drumheller, D.S.

    1998-10-20

    An improved well-pump for geothermal wells, an alignment system for a well-pump, and to a method for aligning a rotor and stator within a well-pump are disclosed, wherein the well-pump has a whistle assembly formed at a bottom portion thereof, such that variations in the frequency of the whistle, indicating misalignment, may be monitored during pumping. 6 figs.

  9. National Ignition Facility system alignment.

    PubMed

    Burkhart, S C; Bliss, E; Di Nicola, P; Kalantar, D; Lowe-Webb, R; McCarville, T; Nelson, D; Salmon, T; Schindler, T; Villanueva, J; Wilhelmsen, K

    2011-03-10

    The National Ignition Facility (NIF) is the world's largest optical instrument, comprising 192 37?cm square beams, each generating up to 9.6?kJ of 351?nm laser light in a 20?ns beam precisely tailored in time and spectrum. The Facility houses a massive (10?m diameter) target chamber within which the beams converge onto an ?1?cm size target for the purpose of creating the conditions needed for deuterium/tritium nuclear fusion in a laboratory setting. A formidable challenge was building NIF to the precise requirements for beam propagation, commissioning the beam lines, and engineering systems to reliably and safely align 192 beams within the confines of a multihour shot cycle. Designing the facility to minimize drift and vibration, placing the optical components in their design locations, commissioning beam alignment, and performing precise system alignment are the key alignment accomplishments over the decade of work described herein. The design and positioning phases placed more than 3000 large (2.5?m×2?m×1?m) line-replaceable optics assemblies to within ±1?mm of design requirement. The commissioning and alignment phases validated clear apertures (no clipping) for all beam lines, and demonstrated automated laser alignment within 10?min and alignment to target chamber center within 44?min. Pointing validation system shots to flat gold-plated x-ray emitting targets showed NIF met its design requirement of ±50??m rms beam pointing to target chamber. Finally, this paper describes the major alignment challenges faced by the NIF Project from inception to present, and how these challenges were met and solved by the NIF design and commissioning teams. PMID:21394186

  10. SYNBIOSAFE e-conference: online community discussion on the societal aspects of synthetic biology.

    PubMed

    Schmidt, Markus; Torgersen, Helge; Ganguli-Mitra, Agomoni; Kelle, Alexander; Deplazes, Anna; Biller-Andorno, Nikola

    2008-06-01

    As part of the SYNBIOSAFE project, we carried out an open electronic conference (e-conference), with the aim to stimulate an open debate on the societal issues of synthetic biology in a proactive way. The e-conference attracted 124 registered participants from 23 different countries and different professional backgrounds, who wrote 182 contributions in six different categories: (I) Ethics; (II) Safety; (III) Security; (IV) IPR; (V) Governance and regulation; (VI) and Public perception. In this paper we discuss the main arguments brought up during the e-conference and provide our conclusions about how the community thinks, and thinks differently on the societal impact of synthetic biology. Finally we conclude that there is a chance for an open discourse on the societal issues of synthetic biology happening, and that the rules to govern such a discourse might be set up much easier and be respected more readily than many would suggest. PMID:19003430

  11. Binocular collimation vs conditional alignment

    NASA Astrophysics Data System (ADS)

    Cook, William J.

    2012-10-01

    As binocular enthusiasts share their passion, topics related to collimation abound. Typically, we find how observers, armed only with a jeweler's screwdriver, can "perfectly collimate" his or her binocular, make it "spot on," or other verbiage of similar connotation. Unfortunately, what most are addressing is a form of pseudo-collimation I have referred to since the mid-1970s as "Conditional Alignment." Ignoring the importance of the mechanical axis (hinge) in the alignment process, this "condition," while having the potential to make alignment serviceable, or even outstanding—within a small range of IPD (Interpupillary Distance) settings relative to the user's spatial accommodation (the ability to accept small errors in parallelism of the optical axes)—may take the instrument farther from the 3-axis collimation conscientious manufacturers seek to implement. Becoming more optically savvy—and especially with so many mechanically inferior binoculars entering the marketplace— the consumer contemplating self-repair and alignment has a need to understand the difference between clinical, 3-axis "collimation" (meaning both optical axes are parallel with the axis of the hinge) and "conditional alignment," as differentiated in this paper. Furthermore, I believe there has been a long-standing need for the term "Conditional Alignment," or some equivalent, to be accepted as part of the vernacular of those who use binoculars extensively, whether for professional or recreational activities. Achieving that acceptance is the aim of this paper.

  12. BinAligner: a heuristic method to align biological networks.

    PubMed

    Yang, Jialiang; Li, Jun; Grünewald, Stefan; Wan, Xiu-Feng

    2013-01-01

    The advances in high throughput omics technologies have made it possible to characterize molecular interactions within and across various species. Alignments and comparison of molecular networks across species will help detect orthologs and conserved functional modules and provide insights on the evolutionary relationships of the compared species. However, such analyses are not trivial due to the complexity of network and high computational cost. Here we develop a mixture of global and local algorithm, BinAligner, for network alignments. Based on the hypotheses that the similarity between two vertices across networks would be context dependent and that the information from the edges and the structures of subnetworks can be more informative than vertices alone, two scoring schema, 1-neighborhood subnetwork and graphlet, were introduced to derive the scoring matrices between networks, besides the commonly used scoring scheme from vertices. Then the alignment problem is formulated as an assignment problem, which is solved by the combinatorial optimization algorithm, such as the Hungarian method. The proposed algorithm was applied and validated in aligning the protein-protein interaction network of Kaposi's sarcoma associated herpesvirus (KSHV) and that of varicella zoster virus (VZV). Interestingly, we identified several putative functional orthologous proteins with similar functions but very low sequence similarity between the two viruses. For example, KSHV open reading frame 56 (ORF56) and VZV ORF55 are helicase-primase subunits with sequence identity 14.6%, and KSHV ORF75 and VZV ORF44 are tegument proteins with sequence identity 15.3%. These functional pairs can not be identified if one restricts the alignment into orthologous protein pairs. In addition, BinAligner identified a conserved pathway between two viruses, which consists of 7 orthologous protein pairs and these proteins are connected by conserved links. This pathway might be crucial for virus packing and infection. PMID:24266981

  13. Circumferentially aligned fibers guided functional neoartery regeneration in vivo.

    PubMed

    Zhu, Meifeng; Wang, Zhihong; Zhang, Jiamin; Wang, Lina; Yang, Xiaohu; Chen, Jingrui; Fan, Guanwei; Ji, Shenglu; Xing, Cheng; Wang, Kai; Zhao, Qiang; Zhu, Yan; Kong, Deling; Wang, Lianyong

    2015-08-01

    An ideal vascular graft should have the ability to guide the regeneration of neovessels with structure and function similar to those of the native blood vessels. Regeneration of vascular smooth muscle cells (VSMCs) with circumferential orientation within the grafts is crucial for functional vascular reconstruction in vivo. To date, designing and fabricating a vascular graft with well-defined geometric cues to facilitate simultaneously VSMCs infiltration and their circumferential alignment remains a great challenge and scarcely reported in vivo. Thus, we have designed a bi-layered vascular graft, of which the internal layer is composed of circumferentially aligned microfibers prepared by wet-spinning and an external layer composed of random nanofibers prepared by electrospinning. While the internal circumferentially aligned microfibers provide topographic guidance for in vivo regeneration of circumferentially aligned VSMCs, the external random nanofibers can offer enhanced mechanical property and prevent bleeding during and after graft implantation. VSMCs infiltration and alignment within the scaffold was then evaluated in vitro and in vivo. Our results demonstrated that the circumferentially oriented VSMCs and longitudinally aligned ECs were successfully regenerated in vivo after the bi-layered vascular grafts were implanted in rat abdominal aorta. No formation of thrombosis or intimal hyperplasia was observed up to 3 month post implantation. Further, the regenerated neoartery exhibited contraction and relaxation property in response to vasoactive agents. This new strategy may bring cell-free small diameter vascular grafts closer to clinical application. PMID:26001073

  14. Long Read Alignment with Parallel MapReduce Cloud Platform.

    PubMed

    Al-Absi, Ahmed Abdulhakim; Kang, Dae-Ki

    2015-01-01

    Genomic sequence alignment is an important technique to decode genome sequences in bioinformatics. Next-Generation Sequencing technologies produce genomic data of longer reads. Cloud platforms are adopted to address the problems arising from storage and analysis of large genomic data. Existing genes sequencing tools for cloud platforms predominantly consider short read gene sequences and adopt the Hadoop MapReduce framework for computation. However, serial execution of map and reduce phases is a problem in such systems. Therefore, in this paper, we introduce Burrows-Wheeler Aligner's Smith-Waterman Alignment on Parallel MapReduce (BWASW-PMR) cloud platform for long sequence alignment. The proposed cloud platform adopts a widely accepted and accurate BWA-SW algorithm for long sequence alignment. A custom MapReduce platform is developed to overcome the drawbacks of the Hadoop framework. A parallel execution strategy of the MapReduce phases and optimization of Smith-Waterman algorithm are considered. Performance evaluation results exhibit an average speed-up of 6.7 considering BWASW-PMR compared with the state-of-the-art Bwasw-Cloud. An average reduction of 30% in the map phase makespan is reported across all experiments comparing BWASW-PMR with Bwasw-Cloud. Optimization of Smith-Waterman results in reducing the execution time by 91.8%. The experimental study proves the efficiency of BWASW-PMR for aligning long genomic sequences on cloud platforms. PMID:26839887

  15. Long Read Alignment with Parallel MapReduce Cloud Platform

    PubMed Central

    Al-Absi, Ahmed Abdulhakim; Kang, Dae-Ki

    2015-01-01

    Genomic sequence alignment is an important technique to decode genome sequences in bioinformatics. Next-Generation Sequencing technologies produce genomic data of longer reads. Cloud platforms are adopted to address the problems arising from storage and analysis of large genomic data. Existing genes sequencing tools for cloud platforms predominantly consider short read gene sequences and adopt the Hadoop MapReduce framework for computation. However, serial execution of map and reduce phases is a problem in such systems. Therefore, in this paper, we introduce Burrows-Wheeler Aligner's Smith-Waterman Alignment on Parallel MapReduce (BWASW-PMR) cloud platform for long sequence alignment. The proposed cloud platform adopts a widely accepted and accurate BWA-SW algorithm for long sequence alignment. A custom MapReduce platform is developed to overcome the drawbacks of the Hadoop framework. A parallel execution strategy of the MapReduce phases and optimization of Smith-Waterman algorithm are considered. Performance evaluation results exhibit an average speed-up of 6.7 considering BWASW-PMR compared with the state-of-the-art Bwasw-Cloud. An average reduction of 30% in the map phase makespan is reported across all experiments comparing BWASW-PMR with Bwasw-Cloud. Optimization of Smith-Waterman results in reducing the execution time by 91.8%. The experimental study proves the efficiency of BWASW-PMR for aligning long genomic sequences on cloud platforms. PMID:26839887

  16. The construction and use of log-odds substitution scores for multiple sequence alignment.

    PubMed

    Altschul, Stephen F; Wootton, John C; Zaslavsky, Elena; Yu, Yi-Kuo

    2010-01-01

    Most pairwise and multiple sequence alignment programs seek alignments with optimal scores. Central to defining such scores is selecting a set of substitution scores for aligned amino acids or nucleotides. For local pairwise alignment, substitution scores are implicitly of log-odds form. We now extend the log-odds formalism to multiple alignments, using Bayesian methods to construct "BILD" ("Bayesian Integral Log-odds") substitution scores from prior distributions describing columns of related letters. This approach has been used previously only to define scores for aligning individual sequences to sequence profiles, but it has much broader applicability. We describe how to calculate BILD scores efficiently, and illustrate their uses in Gibbs sampling optimization procedures, gapped alignment, and the construction of hidden Markov model profiles. BILD scores enable automated selection of optimal motif and domain model widths, and can inform the decision of whether to include a sequence in a multiple alignment, and the selection of insertion and deletion locations. Other applications include the classification of related sequences into subfamilies, and the definition of profile-profile alignment scores. Although a fully realized multiple alignment program must rely upon more than substitution scores, many existing multiple alignment programs can be modified to employ BILD scores. We illustrate how simple BILD score based strategies can enhance the recognition of DNA binding domains, including the Api-AP2 domain in Toxoplasma gondii and Plasmodium falciparum. PMID:20657661

  17. The Construction and Use of Log-Odds Substitution Scores for Multiple Sequence Alignment

    PubMed Central

    Altschul, Stephen F.; Wootton, John C.; Zaslavsky, Elena; Yu, Yi-Kuo

    2010-01-01

    Most pairwise and multiple sequence alignment programs seek alignments with optimal scores. Central to defining such scores is selecting a set of substitution scores for aligned amino acids or nucleotides. For local pairwise alignment, substitution scores are implicitly of log-odds form. We now extend the log-odds formalism to multiple alignments, using Bayesian methods to construct “BILD” (“Bayesian Integral Log-odds”) substitution scores from prior distributions describing columns of related letters. This approach has been used previously only to define scores for aligning individual sequences to sequence profiles, but it has much broader applicability. We describe how to calculate BILD scores efficiently, and illustrate their uses in Gibbs sampling optimization procedures, gapped alignment, and the construction of hidden Markov model profiles. BILD scores enable automated selection of optimal motif and domain model widths, and can inform the decision of whether to include a sequence in a multiple alignment, and the selection of insertion and deletion locations. Other applications include the classification of related sequences into subfamilies, and the definition of profile-profile alignment scores. Although a fully realized multiple alignment program must rely upon more than substitution scores, many existing multiple alignment programs can be modified to employ BILD scores. We illustrate how simple BILD score based strategies can enhance the recognition of DNA binding domains, including the Api-AP2 domain in Toxoplasma gondii and Plasmodium falciparum. PMID:20657661

  18. Emergent Societal Effects of Crimino-Social Forces in an Animat Agent Model

    NASA Astrophysics Data System (ADS)

    Scogings, Chris J.; Hawick, Ken A.

    Societal behaviour can be studied at a causal level by perturbing a stable multi-agent model with new microscopic behaviours and observing the statistical response over an ensemble of simulated model systems. We report on the effects of introducing criminal and law-enforcing behaviours into a large scale animat agent model and describe the complex spatial agent patterns and population changes that result. Our well-established predator-prey substrate model provides a background framework against which these new microscopic behaviours can be trialled and investigated. We describe some quantitative results and some surprising conclusions concerning the overall societal health when individually anti-social behaviour is introduced.

  19. A fair approach to discounting future effects: taking a societal perspective.

    PubMed

    Brouwer, W; van Hout, B; Rutten, F

    2000-04-01

    It is usually recommended that future costs and health effects are discounted at the same rate, usually 5%. In this paper it is argued that, from a societal perspective, this approach may be inappropriate for health effects. Instead of basing the discount rate for health effects on that for costs, it should be based on the real change in the (societal) valuation of health effects over time. Such valuation may change because of increasing life-expectancy and diminishing marginal utility of additional health effects over time. PMID:10947546

  20. Business and IS/IT Strategic Alignment Framework

    NASA Astrophysics Data System (ADS)

    Cuenca, Llanos; Ortiz, Angel; Boza, Andres

    Incorporating information systems and information technology (IS/IT) in the organizations have considerable risks, and these risks are increased when a strategic plan for its incorporation is not done. The objective of this research is to contribute in the alignment between business and IS/IT strategies using concepts and techniques from engineering and enterprise architecture. To achieve this objective, this research proposes to define a modeling framework for business and IS/IT strategic alignment. The implementation of this proposal in a ceramic tile company has helped to validate its usefulness.

  1. Strategies for Success

    ERIC Educational Resources Information Center

    Pruitt, Lisa; McGeough, David

    2011-01-01

    "Training" magazine taps 2011 Training Top 125 winners to provide their learning and development best practices in each issue. This article looks at strategies for aligning training with business goals and creating models to measure return-on-investment (ROI) and other financial metrics pertaining to training.

  2. Gene order alignment on trees with multiOrthoAlign

    PubMed Central

    2014-01-01

    We relate the comparison of gene orders to an alignment problem. Our evolutionary model accounts for both rearrangement and content-modifying events. We present a heuristic based on dynamic programming for the inference of the median of three genomes and apply it in a phylogenetic framework. multiOrthoAlign is shown accurate on simulated and real datasets, and shown to significantly improve the running-time of DupLoCut, an "almost" exact algorithm based on linear programming, developed recently for the same problem. PMID:25572278

  3. DIDA: Distributed Indexing Dispatched Alignment.

    PubMed

    Mohamadi, Hamid; Vandervalk, Benjamin P; Raymond, Anthony; Jackman, Shaun D; Chu, Justin; Breshears, Clay P; Birol, Inanc

    2015-01-01

    One essential application in bioinformatics that is affected by the high-throughput sequencing data deluge is the sequence alignment problem, where nucleotide or amino acid sequences are queried against targets to find regions of close similarity. When queries are too many and/or targets are too large, the alignment process becomes computationally challenging. This is usually addressed by preprocessing techniques, where the queries and/or targets are indexed for easy access while searching for matches. When the target is static, such as in an established reference genome, the cost of indexing is amortized by reusing the generated index. However, when the targets are non-static, such as contigs in the intermediate steps of a de novo assembly process, a new index must be computed for each run. To address such scalability problems, we present DIDA, a novel framework that distributes the indexing and alignment tasks into smaller subtasks over a cluster of compute nodes. It provides a workflow beyond the common practice of embarrassingly parallel implementations. DIDA is a cost-effective, scalable and modular framework for the sequence alignment problem in terms of memory usage and runtime. It can be employed in large-scale alignments to draft genomes and intermediate stages of de novo assembly runs. The DIDA source code, sample files and user manual are available through http://www.bcgsc.ca/platform/bioinfo/software/dida. The software is released under the British Columbia Cancer Agency License (BCCA), and is free for academic use. PMID:25923767

  4. DIDA: Distributed Indexing Dispatched Alignment

    PubMed Central

    Mohamadi, Hamid; Vandervalk, Benjamin P; Raymond, Anthony; Jackman, Shaun D; Chu, Justin; Breshears, Clay P; Birol, Inanc

    2015-01-01

    One essential application in bioinformatics that is affected by the high-throughput sequencing data deluge is the sequence alignment problem, where nucleotide or amino acid sequences are queried against targets to find regions of close similarity. When queries are too many and/or targets are too large, the alignment process becomes computationally challenging. This is usually addressed by preprocessing techniques, where the queries and/or targets are indexed for easy access while searching for matches. When the target is static, such as in an established reference genome, the cost of indexing is amortized by reusing the generated index. However, when the targets are non-static, such as contigs in the intermediate steps of a de novo assembly process, a new index must be computed for each run. To address such scalability problems, we present DIDA, a novel framework that distributes the indexing and alignment tasks into smaller subtasks over a cluster of compute nodes. It provides a workflow beyond the common practice of embarrassingly parallel implementations. DIDA is a cost-effective, scalable and modular framework for the sequence alignment problem in terms of memory usage and runtime. It can be employed in large-scale alignments to draft genomes and intermediate stages of de novo assembly runs. The DIDA source code, sample files and user manual are available through http://www.bcgsc.ca/platform/bioinfo/software/dida. The software is released under the British Columbia Cancer Agency License (BCCA), and is free for academic use. PMID:25923767

  5. Global Alignment System for Large Genomic Sequencing

    Energy Science and Technology Software Center (ESTSC)

    2002-03-01

    AVID is a global alignment system tailored for the alignment of large genomic sequences up to megabases in length. Features include the possibility of one sequence being in draft form, fast alignment, robustness and accuracy. The method is an anchor based alignment using maximal matches derived from suffix trees.

  6. Space-Based Sensor Web for Earth Science Applications: An Integrated Architecture for Providing Societal Benefits

    NASA Technical Reports Server (NTRS)

    Habib, Shahid; Talabac, Stephen J.

    2004-01-01

    There is a significant interest in the Earth Science research and user remote sensing community to substantially increase the number of useful observations relative to the current frequency of collection. The obvious reason for such a push is to improve the temporal, spectral, and spatial coverage of the area(s) under investigation. However, there is little analysis available in terms of the benefits, costs and the optimal set of sensors needed to make the necessary observations. Classic observing system solutions may no longer be applicable because of their point design philosophy. Instead, a new intelligent data collection system paradigm employing both reactive and proactive measurement strategies with adaptability to the dynamics of the phenomena should be developed. This is a complex problem that should be carefully studied and balanced across various boundaries including: science, modeling, applications, and technology. Modeling plays a crucial role in making useful predictions about naturally occurring or human-induced phenomena In particular, modeling can serve to mitigate the potentially deleterious impacts a phenomenon may have on human life, property, and the economy. This is especially significant when one is interested in learning about the dynamics of, for example, the spread of forest fires, regional to large-scale air quality issues, the spread of the harmful invasive species, or the atmospheric transport of volcanic plumes and ash. This paper identifies and examines these challenging issues and presents architectural alternatives for an integrated sensor web to provide observing scenarios driving the requisite dynamic spatial, spectral, and temporal characteristics to address these key application areas. A special emphasis is placed on the observing systems and its operational aspects in serving the multiple users and stakeholders in providing societal benefits. We also address how such systems will take advantage of technological advancement in small spacecraft and emerging information technologies, and how sensor web options may be realized and made affordable. Specialized detector subsystems and precision flying techniques may still require substantial innovation, development time and cost: we have presented the considerations for these issues. Finally, data and information gathering and compression techniques are also briefly described.

  7. Carbon Nanotube Based Nanotechnology for NASA Mission Needs and Societal Applications

    NASA Technical Reports Server (NTRS)

    Li, Jing; Meyyappan, M.

    2011-01-01

    Carbon nanotubes (CNT) exhibit extraordinary mechanical properties and unique electronic properties and therefore, have received much attention for more than a decade now for a variety of applications ranging from nanoelectronics, composites to meeting needs in energy, environmental and other sectors. In this talk, we focus on some near term potential of CNT applications for both NASA and other Agency/societal needs. The most promising and successful application to date is a nano chem sensor at TRL 6 that uses a 16-256 sensor array in the construction of an electronic nose. Pristine, doped, functionalized and metal-loaded SWCNTs are used as conducting materials to provide chemical variation across the individual elements of the sensor array. This miniaturized sensor has been incorporated in an iPhone for homeland security applications. Gases and vapors relevant to leak detection in crew vehicles, biomedical, mining, chemical threats, industrial spills and others have been demonstrated. SWCNTs also respond to radiation exposure via a change in conductivity and therefore, a similar strategy is being pursued to construct a radiation nose to identify radiation sources (gamma, protons, neutrons, X-ray, etc.) with their energy levels. Carbon nanofibers (CNFs) grown using plasma enhanced CVD typically are vertical, individual, freestanding structures and therefore, are ideal for construction of nanoelectrodes. A nanoelectrode array (NEA) can be the basis for an affinity-based biosensor to meet the needs in applications such as lab-on-a-chip, environmental monitoring, cancer diagnostics, biothreat monitoring, water and food safety and others. A couple of demonstrations including detection of e-coli and ricin will be discussed. The NEA is also useful for implantation in the brain for deep brain stimulation and neuroengineering applications. Miniaturization of payload such as science instrumentation and power sources is critical to reduce launch costs. High current density (greater than 100 mA/per square centimeters) field emission capabilities of CNTs can be exploited for construction of electron gun for electron microscopy and X-ray tubes for spectrometers and baggage screening. A CNT pillar array configuration has been demonstrated, not only meeting the high current density needs but more importantly providing long term emitter stability. Finally, supercapacitors hold the promise to combine the high energy density of a battery with the high power density of capacitors. Traditional graphite electrodes have not delivered this promise yet. A novel design and processing approach using MWCNTs has shown a record 550 F/g capacitance along with significant device endurance. This supercapacitor is suitable for railgun launch application for NASA, powering rovers and robots, consumer electronics and future hybrid vehicles.

  8. Alignment method for parabolic trough solar concentrators

    DOEpatents

    Diver, Richard B. (Albuquerque, NM)

    2010-02-23

    A Theoretical Overlay Photographic (TOP) alignment method uses the overlay of a theoretical projected image of a perfectly aligned concentrator on a photographic image of the concentrator to align the mirror facets of a parabolic trough solar concentrator. The alignment method is practical and straightforward, and inherently aligns the mirror facets to the receiver. When integrated with clinometer measurements for which gravity and mechanical drag effects have been accounted for and which are made in a manner and location consistent with the alignment method, all of the mirrors on a common drive can be aligned and optimized for any concentrator orientation.

  9. Combining Multiple Pairwise Structure-based Alignments

    SciTech Connect

    2014-11-12

    CombAlign is a new Python code that generates a gapped, one-to-many, multiple structure-based sequence alignment(MSSA) given a set of pairwise structure-based alignments. In order to better define regions of similarity among related protein structures, it is useful to detect the residue-residue correspondences among a set of pairwise structure alignments. Few codes exist for constructing a one-to-many, multiple sequence alignment derived from a set of structure alignments, and we perceived a need for creating a new tool for combing pairwise structure alignments that would allow for insertion of gaps in the reference structure.

  10. The Inter-Temporal Aspect of Well-Being and Societal Progress

    ERIC Educational Resources Information Center

    Sicherl, Pavle

    2007-01-01

    The perceptions on well-being and societal progress are influenced also by the quantitative indicators and measures used in the measurement, presentation and semantics of discussing these issues. The article presents a novel generic statistical measure S-time-distance, with clear interpretability that delivers a broader concept to look at data, to…

  11. NANO SCENARIO: Role-Playing to Appreciate the Societal Effects of Nanotechnology

    ERIC Educational Resources Information Center

    Jarmon, Leslie; Keating, Elizabeth

    2008-01-01

    This article describes a university-sponsored experiential-based simulation, the NANO SCENARIO, to increase the public's awareness and affect attitudes on the societal implications of nanoscience and nanotechnology by bringing together diverse stakeholders' perspectives in a participatory learning environment. Nanotechnology has the potential for…

  12. Teaching Societal and Ethical Implications of Nanotechnology to Engineering Students through Science Fiction

    ERIC Educational Resources Information Center

    Berne, Rosalyn W.; Schummer, Joachim

    2005-01-01

    Societal and ethical implications of nanotechnology have become a hot topic of public debates in many countries because both revolutionary changes and strong public concerns are expected from its development. Because nanotechnology is, at this point, mostly articulated in visionary and futuristic terms, it is difficult to apply standard methods of…

  13. Piecing Together the Puzzle: Development of the Societal Attitudes towards Autism (SATA) Scale

    ERIC Educational Resources Information Center

    Flood, Luci N.; Bulgrin, Amanda; Morgan, Betsy L.

    2013-01-01

    The rise in the prevalence of autism creates a need for a reliable and valid measure of attitudes towards autism. The current study describes the development of a brief 16-item measure of Societal Attitudes towards Autism (SATA) that exhibits sound psychometric properties and has a demonstrated ability to discriminate between expert and general…

  14. Media Use and Children's Perceptions of Societal Threat and Personal Vulnerability

    ERIC Educational Resources Information Center

    Comer, Jonathan S.; Furr, Jami M.; Beidas, Rinad S.; Babyar, Heather M.; Kendall, Philip C.

    2008-01-01

    This study examined children's media use (i.e., amount of television and Internet usage) and relationships to children's perceptions of societal threat and personal vulnerability. The sample consisted of 90 community youth aged 7 to 13 years (M = 10.8; 52.2% male) from diverse economic backgrounds. Analyses found children's television use to be…

  15. A Study of Societal Factors Influencing the Growth of Castleton State College: Implications for Future Trends.

    ERIC Educational Resources Information Center

    Forest, Robert F.

    Analyzed are certain societal factors--political, demographic, financial, public relations, student profiles, and mission statements as they have influenced the growth of Castleton State College since becoming a member of the Vermont State College system in 1961. Data for the study were gathered from a literature review of one of the daily…

  16. Information System for Societal Cost and Benefit Analysis of Vocational and Manpower Programs. Final Report.

    ERIC Educational Resources Information Center

    Arora, Mehar

    The study was directed toward developing a manual for establishing societal benefits and costs of vocational and manpower programs in Wisconsin. After first outlining the background of benefit-cost analysis, problems in establishing cost functions in education are presented along with some important cost concepts and uses of cost information in…

  17. Social Change, Competition and Inequality: Macro Societal Patterns Reflected in Curriculum Practices of Turkish Schools

    ERIC Educational Resources Information Center

    Somel, Rahsan Nazli; Nohl, Arnd-Michael

    2015-01-01

    Curriculum reforms provide a unique opportunity to investigate how in times of social change education is not only influenced by, but also itself a driver of, competition and inequality. This article sheds light on a specific instance of how macro-societal patterns in education intermingle in twenty-first century Turkey by inquiring into a major…

  18. Societal Burden of Clinically Anxious Youth Referred for Treatment: A Cost-of-Illness Study

    ERIC Educational Resources Information Center

    Bodden, Denise H. M.; Dirksen, Carmen D.; Bogels, Susan M.

    2008-01-01

    A prevalence-based cost-of-illness study using a societal perspective was conducted to investigate the cost-of-illness in clinically anxious youth aged 8-18 in The Netherlands. Discriminant validity of the cost diary used was obtained by comparing costs of families with an anxious child (n=118) to costs of families from the general population…

  19. Societal Burden of Clinically Anxious Youth Referred for Treatment: A Cost-of-Illness Study

    ERIC Educational Resources Information Center

    Bodden, Denise H. M.; Dirksen, Carmen D.; Bogels, Susan M.

    2008-01-01

    A prevalence-based cost-of-illness study using a societal perspective was conducted to investigate the cost-of-illness in clinically anxious youth aged 8-18 in The Netherlands. Discriminant validity of the cost diary used was obtained by comparing costs of families with an anxious child (n=118) to costs of families from the general population…

  20. Soil Carbon Sequestration in Grazing Lands: Societal Benefits and Policay Implications

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Here we examine the importance of ‘grazinglands’ in relation to the sequestration of soil organic carbon. Global estimates are that grazinglands occupy~ 3.6 billion ha and account for about one-fourth of potential C sequestration in world soils. Many environmental and societal benefits are provide...

  1. Barriers to Considering Ethical and Societal Implications of Research: Perceptions of Life Scientists.

    PubMed

    McCormick, Jennifer Blair; Boyce, Angie M; Ladd, Jennifer M; Cho, Mildred

    2012-01-01

    BACKGROUND: As part of an empirical study investigating how life scientists think about ethical and societal implications of their work, and about life science research in general, we sought to elucidate barriers that scientists might face in considering such implications. METHOD: Between 2005 and 2007, we conducted a study consisting of phone interviews, focus groups, and a national survey of life scientists at biomedical research institutions. The study population included graduate students, postdoctoral fellows, faculty, clinical instructors, and research staff. We analyzed data through qualitative and quantitative methods. RESULTS: In analyzing the data, we found that life scientists do, in fact, face barriers to considering ethical and societal implications of research. We categorized these barriers as falling into four broad domains: (1) lack of awareness of ethical and societal implications; (2) lack of relevance of such concerns to their specific research; (3) self-confidence in their ability to resolve such concerns; and (4) aspects of the daily practice of science itself. CONCLUSIONS: Life science researchers experience elements inherent in their training and in the conduct of science as barriers to thinking about ethical and societal implications related to their work. These findings suggest areas in which research ethics educators, bioethicists, and the scientific community can focus their efforts to improve social and ethical accountability in research. PMID:22866239

  2. Citizens of the Academic Community? A Societal Perspective on Leadership in UK Higher Education

    ERIC Educational Resources Information Center

    Bolden, Richard; Gosling, Jonathan; O'Brien, Anne

    2014-01-01

    This paper presents a societal perspective on academic leadership by exploring the preoccupations of academics as citizens rather than as employees, managers or individuals. It uses a listening post methodology to ask "what is it like to be a citizen of an academic institution in contemporary Britain?" Three listening posts, comprising…

  3. Teaching Societal and Ethical Implications of Nanotechnology to Engineering Students through Science Fiction

    ERIC Educational Resources Information Center

    Berne, Rosalyn W.; Schummer, Joachim

    2005-01-01

    Societal and ethical implications of nanotechnology have become a hot topic of public debates in many countries because both revolutionary changes and strong public concerns are expected from its development. Because nanotechnology is, at this point, mostly articulated in visionary and futuristic terms, it is difficult to apply standard methods of…

  4. APPLICATION OF BEST AVAILABLE SCIENCE TO SOCIETAL DECISIONS: ENVIRONMENTAL PROTECTION BASED ON BEST AVAILABLE SCIENCE

    SciTech Connect

    MOGHISSI, A ALAN; LOVE, BETTY R; STRAJA, SORIN R

    2007-06-30

    This grant covered several areas of significant societal interest. It included an evaluation of the validity of scientific claims; developed an approach for stakeholder participation; and demonstrated the validity of the developed methods through the performance of a number of independent peer reviews.

  5. Social Change, Competition and Inequality: Macro Societal Patterns Reflected in Curriculum Practices of Turkish Schools

    ERIC Educational Resources Information Center

    Somel, Rahsan Nazli; Nohl, Arnd-Michael

    2015-01-01

    Curriculum reforms provide a unique opportunity to investigate how in times of social change education is not only influenced by, but also itself a driver of, competition and inequality. This article sheds light on a specific instance of how macro-societal patterns in education intermingle in twenty-first century Turkey by inquiring into a major…

  6. Societal Duty and Resource Allocation for Persons with Severe Traumatic Brain Injury.

    ERIC Educational Resources Information Center

    DeJong, Gerben; Batavia, Andrew I.

    1989-01-01

    The article considers eight values and factors that enter into decisions regarding resource allocation for persons with brain injury including the quality of life, moral culpability of the brain-injured person, the social contribution of the person, allocation of family and societal responsibilities, justice, the nature of health care, and…

  7. National Contexts Influencing Principals' Time Use and Allocation: Economic Development, Societal Culture, and Educational System

    ERIC Educational Resources Information Center

    Lee, Moosung; Hallinger, Philip

    2012-01-01

    This study examines the impact of macro-context factors on the behavior of school principals. More specifically, the article illuminates how a nation's level of economic development, societal culture, and educational system influence the amount of time principals devote to their job role and shape their allocation of time to instructional…

  8. Media Use and Children's Perceptions of Societal Threat and Personal Vulnerability

    ERIC Educational Resources Information Center

    Comer, Jonathan S.; Furr, Jami M.; Beidas, Rinad S.; Babyar, Heather M.; Kendall, Philip C.

    2008-01-01

    This study examined children's media use (i.e., amount of television and Internet usage) and relationships to children's perceptions of societal threat and personal vulnerability. The sample consisted of 90 community youth aged 7 to 13 years (M = 10.8; 52.2% male) from diverse economic backgrounds. Analyses found children's television use to be…

  9. Piecing Together the Puzzle: Development of the Societal Attitudes towards Autism (SATA) Scale

    ERIC Educational Resources Information Center

    Flood, Luci N.; Bulgrin, Amanda; Morgan, Betsy L.

    2013-01-01

    The rise in the prevalence of autism creates a need for a reliable and valid measure of attitudes towards autism. The current study describes the development of a brief 16-item measure of Societal Attitudes towards Autism (SATA) that exhibits sound psychometric properties and has a demonstrated ability to discriminate between expert and general…

  10. Societal Uplift and Productive Efficiency: Corporate Use of Vocational Education in Ellsworth, Pennsylvania, 1900-1915.

    ERIC Educational Resources Information Center

    Hyser, Raymond M.

    About 1900, James W. Ellsworth created the educational system of Ellsworth, Pennsylvania. His aim was to have the system serve a dual purpose: the societal uplift of foreign miners to make them better citizens and the improvement of the company's productive efficiency. Ellsworth's school offered traditional courses along with training in English…

  11. Contributions of Societal Modernity to Cognitive Development: A Comparison of Four Cultures

    ERIC Educational Resources Information Center

    Gauvain, Mary; Munroe, Robert L.

    2009-01-01

    This study examined how societal changes associated with modernization are related to cognitive development. Data were from 4 cultural communities that represented a broad range of traditional and modern elements: the Garifuna (Belize), Logoli (Kenya), Newars (Nepal), and Samoans (American Samoa). Naturalistic observations and the performances of…

  12. Incorporation of Ethical and Societal Issues in Biochemistry into a Senior Seminar Course

    ERIC Educational Resources Information Center

    Caspers, Mary Lou; Roberts-Kirchhoff, Elizabeth S.

    2003-01-01

    In their senior year, biochemistry majors at the University of Detroit Mercy take a senior seminar course entitled "Recent Advances in Biochemistry Related to Societal Issues." Students read papers selected from the current literature and take turns presenting these papers to the class. Papers are grouped into units dealing with molecular biology,…

  13. Societal Factors Affecting Communication and Cooperation Between Industry and Accounting Education at Castleton State College.

    ERIC Educational Resources Information Center

    O'Neil, Bryan L.

    The purpose of the practicum was to determine the societal factors existing in the accounting industry and accounting education, with the aim of integrating the changing regulations and environment of the industry into the classroom at Castleton State College (Vermont). A group of certified public accountants were surveyed by Likert scale to learn…

  14. Incorporation of Ethical and Societal Issues in Biochemistry into a Senior Seminar Course

    ERIC Educational Resources Information Center

    Caspers, Mary Lou; Roberts-Kirchhoff, Elizabeth S.

    2003-01-01

    In their senior year, biochemistry majors at the University of Detroit Mercy take a senior seminar course entitled "Recent Advances in Biochemistry Related to Societal Issues." Students read papers selected from the current literature and take turns presenting these papers to the class. Papers are grouped into units dealing with molecular biology,…

  15. Awareness of Societal Issues among High School Biology Teachers Teaching Genetics

    ERIC Educational Resources Information Center

    Lazarowitz, Reuven; Bloch, Ilit

    2005-01-01

    The purpose of this study was to investigate how aware high school biology teachers are of societal issues (values, moral, ethic, and legal issues) while teaching genetics, genetics engineering, molecular genetics, human heredity, and evolution. The study includes a short historical review of World War II atrocities during the Holocaust when…

  16. NANO SCENARIO: Role-Playing to Appreciate the Societal Effects of Nanotechnology

    ERIC Educational Resources Information Center

    Jarmon, Leslie; Keating, Elizabeth

    2008-01-01

    This article describes a university-sponsored experiential-based simulation, the NANO SCENARIO, to increase the public's awareness and affect attitudes on the societal implications of nanoscience and nanotechnology by bringing together diverse stakeholders' perspectives in a participatory learning environment. Nanotechnology has the potential for…

  17. National Contexts Influencing Principals' Time Use and Allocation: Economic Development, Societal Culture, and Educational System

    ERIC Educational Resources Information Center

    Lee, Moosung; Hallinger, Philip

    2012-01-01

    This study examines the impact of macro-context factors on the behavior of school principals. More specifically, the article illuminates how a nation's level of economic development, societal culture, and educational system influence the amount of time principals devote to their job role and shape their allocation of time to instructional…

  18. Local spatial and temporal factors influencing population and societal vulnerability to natural disasters.

    PubMed

    Zhou, Yang; Li, Ning; Wu, Wenxiang; Wu, Jidong; Shi, Peijun

    2014-04-01

    The identification of societal vulnerable counties and regions and the factors contributing to social vulnerability are crucial for effective disaster risk management. Significant advances have been made in the study of social vulnerability over the past two decades, but we still know little regarding China's societal vulnerability profiles, especially at the county level. This study investigates the county-level spatial and temporal patterns in social vulnerability in China from 1980 to 2010. Based on China's four most recent population censuses of 2,361 counties and their corresponding socioeconomic data, a social vulnerability index for each county was created using factor analysis. Exploratory spatial data analysis, including global and local autocorrelations, was applied to reveal the spatial patterns of county-level social vulnerability. The results demonstrate that the dynamic characteristics of China's county-level social vulnerability are notably distinct, and the dominant contributors to societal vulnerability for all of the years studied were rural character, development (urbanization), and economic status. The spatial clustering patterns of social vulnerability to natural disasters in China exhibited a gathering-scattering-gathering pattern over time. Further investigations indicate that many counties in the eastern coastal area of China are experiencing a detectable increase in social vulnerability, whereas the societal vulnerability of many counties in the western and northern areas of China has significantly decreased over the past three decades. These findings will provide policymakers with a sound scientific basis for disaster prevention and mitigation decisions. PMID:24673569

  19. Social Cohesion and the Labour Market: Societal Regimes of Civic Attitudes and Labour Market Regimes

    ERIC Educational Resources Information Center

    Dimeglio, Isabelle; Janmaat, Jan Germen; Mehaut, Philippe

    2013-01-01

    The aim of this paper is to test the connections between the indicators used in the literature on social cohesion, which usually reflect "general" values or behaviours, and indicators specific to a particular space, namely the labour market. A key question is the stability of the social cohesion's indicators when moving from a societal level to…

  20. Awareness of Societal Issues among High School Biology Teachers Teaching Genetics

    ERIC Educational Resources Information Center

    Lazarowitz, Reuven; Bloch, Ilit

    2005-01-01

    The purpose of this study was to investigate how aware high school biology teachers are of societal issues (values, moral, ethic, and legal issues) while teaching genetics, genetics engineering, molecular genetics, human heredity, and evolution. The study includes a short historical review of World War II atrocities during the Holocaust when…

  1. The Teaching and Societal Services Nexus: Academics' Experiences in Three Disciplines

    ERIC Educational Resources Information Center

    Holmén, Magnus; Ljungberg, Daniel

    2015-01-01

    In this paper, we investigate the perception of academics regarding how their experiences from societal interaction (third mission) inform their teaching and vice versa. We report on a phone survey of Swedish academics in three engineering-related disciplines. The findings show that there is a perceived positive and bidirectional relationship…

  2. Multiple sequence alignment with hierarchical clustering.

    PubMed Central

    Corpet, F

    1988-01-01

    An algorithm is presented for the multiple alignment of sequences, either proteins or nucleic acids, that is both accurate and easy to use on microcomputers. The approach is based on the conventional dynamic-programming method of pairwise alignment. Initially, a hierarchical clustering of the sequences is performed using the matrix of the pairwise alignment scores. The closest sequences are aligned creating groups of aligned sequences. Then close groups are aligned until all sequences are aligned in one group. The pairwise alignments included in the multiple alignment form a new matrix that is used to produce a hierarchical clustering. If it is different from the first one, iteration of the process can be performed. The method is illustrated by an example: a global alignment of 39 sequences of cytochrome c. PMID:2849754

  3. High-performance Flexible Photodetectors based on Aligned Cadmium Sulfide Nanowire Networks

    NASA Astrophysics Data System (ADS)

    Cho, Dong-Guk; Heo, Kwang; Lee, Hyungwoo; Park, Yongju; Park, Jinho; Lim, Hyun-Jin; Yoon, Duhee; Lee, Changhee; Kim, Miyoung; Cheong, Hyeonsik; Park, Jonghyurk; Jian, Jikang; Hong, Seunghun

    2013-03-01

    We developed a method to mass-produce aligned cadmium sulfide (CdS) nanowire (NW) network channels for highly flexible and high-performance photodetectors. In this method, CdS NWs were aligned along the molecular patterns on flexible substrates by a directed assembly strategy. The aligned CdS NW patterns were utilized as the channel of flexible photodetectors. The photodetectors based on aligned CdS NWs showed ~ 10 times higher photosensitivity and ~ 100 times faster photoresponse than those based on randomly-oriented CdS NW networks. Additionally, the stable photoconductive characteristics of our flexible photodetectors were maintained even when the photodetectors were bent down to a 0.2 mm radius of curvature. This simple but efficient strategy should pave the way for the large-scale fabrication of low-cost and high-performance flexible photodetectors based on the aligned CdS NW networks.

  4. Analysis of Water Conflicts across Natural and Societal Boundaries: Integration of Quantitative Modeling and Qualitative Reasoning

    NASA Astrophysics Data System (ADS)

    Gao, Y.; Balaram, P.; Islam, S.

    2009-12-01

    Water issues and problems have bewildered humankind for a long time yet a systematic approach for understanding such issues remain elusive. This is partly because many water-related problems are framed from a contested terrain in which many actors (individuals, communities, businesses, NGOs, states, and countries) compete to protect their own and often conflicting interests. We argue that origin of many water problems may be understood as a dynamic consequence of competition, interconnections, and feedback among variables in the Natural and Societal Systems (NSSs). Within the natural system, we recognize that triple constraints on water- water quantity (Q), water quality (P), and ecosystem (E)- and their interdependencies and feedback may lead to conflicts. Such inherent and multifaceted constraints of the natural water system are exacerbated often at the societal boundaries. Within the societal system, interdependencies and feedback among values and norms (V), economy (C), and governance (G) interact in various ways to create intractable contextual differences. The observation that natural and societal systems are linked is not novel. Our argument here, however, is that rigid disciplinary boundaries between these two domains will not produce solutions to the water problems we are facing today. The knowledge needed to address water problems need to go beyond scientific assessment in which societal variables (C, G, and V) are treated as exogenous or largely ignored, and policy research that does not consider the impact of natural variables (E, P, and Q) and that coupling among them. Consequently, traditional quantitative methods alone are not appropriate to address the dynamics of water conflicts, because we cannot quantify the societal variables and the exact mathematical relationships among the variables are not fully known. On the other hand, conventional qualitative study in societal domain has mainly been in the form of individual case studies and therefore, the knowledge generated from these studies cannot be easily generalized or transferred to other basins. Here, we present an approach to integrate the quantitative and qualitative methods to study water issues and capture the contextual knowledge of water management- by combining the NSSs framework and an area of artificial intelligence called qualitative reasoning. Using the Apalachicola-Chattahoochee-Flint (ACF) River Basin dispute as an example, we demonstrate how quantitative modeling and qualitative reasoning can be integrated to examine the impact of over abstraction of water from the river on the ecosystem and the role of governance in shaping the evolution of the ACF water dispute.

  5. Grain alignment in starless cores

    SciTech Connect

    Jones, T. J.; Bagley, M.; Krejny, M.; Andersson, B.-G.; Bastien, P.

    2015-01-01

    We present near-IR polarimetry data of background stars shining through a selection of starless cores taken in the K band, probing visual extinctions up to A{sub V}?48. We find that P{sub K}/?{sub K} continues to decline with increasing A{sub V} with a power law slope of roughly ?0.5. Examination of published submillimeter (submm) polarimetry of starless cores suggests that by A{sub V}?20 the slope for P versus ? becomes ??1, indicating no grain alignment at greater optical depths. Combining these two data sets, we find good evidence that, in the absence of a central illuminating source, the dust grains in dense molecular cloud cores with no internal radiation source cease to become aligned with the local magnetic field at optical depths greater than A{sub V}?20. A simple model relating the alignment efficiency to the optical depth into the cloud reproduces the observations well.

  6. Sequence Alignment Tools: One Parallel Pattern to Rule Them All?

    PubMed Central

    2014-01-01

    In this paper, we advocate high-level programming methodology for next generation sequencers (NGS) alignment tools for both productivity and absolute performance. We analyse the problem of parallel alignment and review the parallelisation strategies of the most popular alignment tools, which can all be abstracted to a single parallel paradigm. We compare these tools to their porting onto the FastFlow pattern-based programming framework, which provides programmers with high-level parallel patterns. By using a high-level approach, programmers are liberated from all complex aspects of parallel programming, such as synchronisation protocols, and task scheduling, gaining more possibility for seamless performance tuning. In this work, we show some use cases in which, by using a high-level approach for parallelising NGS tools, it is possible to obtain comparable or even better absolute performance for all used datasets. PMID:25147803

  7. Is the Societal burden of fatal occupational injury different among NORA industry sectors?

    PubMed Central

    Biddle, Elyce Anne

    2015-01-01

    Problem Since the implementation of the Occupational Safety and Health Act, safety and health in the work environment has seen marked improvement. Although these improvements are laudable, workplace hazards continue to plague the American worker. Understanding the economic burden of fatalities by industry sector is important to setting broad occupational safety and health research priorities. Cost estimates provide additional information about how fatal injuries affect society and hence can improve injury prevention program planning, policy analysis, evaluation, and advocacy. Method This study estimated the total, mean, and median societal costs by worker and case characteristic in 2003–2006 for the industry sectors identified in the National Institute for Occupational Safety and Health National Occupational Research Agenda (NORA). Analyses were conducted with restricted access to the Bureau of Labor Statistics Census of Fatal Occupational Injuries data. These data exclude military personnel, decedents with unknown age or sex, and fatalities occurring in New York City. Societal costs were estimated using the cost-of-illness approach, which combines direct and indirect costs to yield an overall cost of an fatal occupational injury. Results During this period, the cost of the 22,197 fatal occupational injuries exceeded $21 billion. The mean and median costs of these fatalities were $960,000 and $944,000 respectively. Total societal costs by NORA sector ranged from a high of $5.8 billion in Services to a low of $530 million in Healthcare and Social Assistance with mean costs ranging from the nearly $800,000 in Agriculture, Forestry, and Fishing to almost $1.1 million in Mining. Discussion The societal costs—total, mean, and median costs—of case and worker characteristics for occupational fatal injuries varied within each NORA sector. Impact on Industry To have the greatest societal impact, these costs can be used to target resources for public and private sector research by industry. PMID:23398699

  8. Optimization of PSA Screening Policies: a Comparison of the Patient and Societal Perspectives

    PubMed Central

    Zhang, Jingyu; Denton, Brian T.; Balasubramanian, Hari; Shah, Nilay D.; Inman, Brant A.

    2011-01-01

    Objective To estimate the benefit of PSA-based screening for prostate cancer from the patient and societal perspectives. Method A partially observable Markov decision process (POMDP) model was used to optimize PSA screening decisions. We considered age-specific prostate cancer incidence rates and the mortality rates from prostate cancer and competing causes. Our model trades off the potential benefit of early detection with the cost of screening and loss of patient quality of life due to screening and treatment. PSA testing and biopsy decisions are made based on the patient’s probability of having prostate cancer. Probabilities are inferred based on the patient’s complete PSA history using Bayesian updating. Data Sources The results of all PSA tests and biopsies done in Olmsted County, Minnesota from 1993 to 2005 (11,872 men and 50,589 PSA test results). Perspective and Outcome Measures Patients’ perspective: maximize expected quality-adjusted life years (QALYs); societal perspective: maximize the expected monetary value based on societal willingness to pay for QALYs and the cost of PSA testing, prostate biopsies and treatment. Results From the patient perspective the optimal policy recommends stopping PSA testing and biopsy at age 76. From the societal perspective the stopping age is 71. The expected incremental benefit of optimal screening over the traditional guideline of annual PSA screening with threshold 4.0 ng/mL for biopsy is estimated to be 0.165 QALYs per person from the patient perspective, and 0.161 QALYs per person from the societal perspective. PSA screening based on traditional guidelines is found to be worse than no screening at all. Conclusions PSA testing done with traditional guidelines underperforms and therefore underestimates the potential benefit of screening. Optimal screening guidelines differ significantly depending on the perspective of the decision maker. PMID:21933990

  9. Graceful Failure and Societal Resilience Analysis Via Agent-Based Modeling and Simulation

    NASA Astrophysics Data System (ADS)

    Schopf, P. S.; Cioffi-Revilla, C.; Rogers, J. D.; Bassett, J.; Hailegiorgis, A. B.

    2014-12-01

    Agent-based social modeling is opening up new methodologies for the study of societal response to weather and climate hazards, and providing measures of resiliency that can be studied in many contexts, particularly in coupled human and natural-technological systems (CHANTS). Since CHANTS are complex adaptive systems, societal resiliency may or may not occur, depending on dynamics that lack closed form solutions. Agent-based modeling has been shown to provide a viable theoretical and methodological approach for analyzing and understanding disasters and societal resiliency in CHANTS. Our approach advances the science of societal resilience through computational modeling and simulation methods that complement earlier statistical and mathematical approaches. We present three case studies of social dynamics modeling that demonstrate the use of these agent based models. In Central Asia, we exmaine mutltiple ensemble simulations with varying climate statistics to see how droughts and zuds affect populations, transmission of wealth across generations, and the overall structure of the social system. In Eastern Africa, we explore how successive episodes of drought events affect the adaptive capacity of rural households. Human displacement, mainly, rural to urban migration, and livelihood transition particularly from pastoral to farming are observed as rural households interacting dynamically with the biophysical environment and continually adjust their behavior to accommodate changes in climate. In the far north case we demonstrate one of the first successful attempts to model the complete climate-permafrost-infrastructure-societal interaction network as a complex adaptive system/CHANTS implemented as a ``federated'' agent-based model using evolutionary computation. Analysis of population changes resulting from extreme weather across these and other cases provides evidence for the emergence of new steady states and shifting patterns of resilience.

  10. The how and why of societal publications for citizen science projects and scientists.

    PubMed

    van Vliet, Arnold J H; Bron, Wichertje A; Mulder, Sara

    2014-05-01

    In the scientific community, the importance of communication to society is often underestimated. Scientists and scientific organisations often lack the skills to organise such communication effectively. The Dutch citizen science phenology network Nature's Calendar has been successful in communicating to the general public via numerous newspaper articles, television appearances, presentations, websites and social media. We refer to these publications as societal publications. Due to active communication to mass media, we frequently reach millions of people. This communication helped us to involve thousands of volunteers in recording the timing of phenological events like the start of flowering, leaf unfolding and bird migration, but also several health-related events like hay fever symptoms and tick bites. In this paper, we analyse and present our experiences with the Nature's Calendar project regarding societal publications. Based on this analysis, we explain the importance of societal publications for citizen science projects and scientists in general, and we show how scientists can increase the news worthiness of scientific information and what factors and activities can increase the chances of media paying attention to this news. We show that societal publications help phenological networks by facilitating the recruitment, retention and instruction of observers. Furthermore, they stimulate the generation of new ideas and partners that lead to an increase in knowledge, awareness and behavioural change of the general public or specific stakeholders. They make projects, and scientists involved, better known to the public and increase their credibility and authority. Societal publications can catalyse the production of new publications, thereby enforcing the previous mentioned points. PMID:24705824

  11. Model Based Reasoning by Introductory Students When Analyzing Earth Systems and Societal Challenges

    NASA Astrophysics Data System (ADS)

    Holder, L. N.; Herbert, B. E.

    2014-12-01

    Understanding how students use their conceptual models to reason about societal challenges involving societal issues such as natural hazard risk assessment, environmental policy and management, and energy resources can improve instructional activity design that directly impacts student motivation and literacy. To address this question, we created four laboratory exercises for an introductory physical geology course at Texas A&M University that engages students in authentic scientific practices by using real world problems and issues that affect societies based on the theory of situated cognition. Our case-study design allows us to investigate the various ways that students utilize model based reasoning to identify and propose solutions to societally relevant issues. In each of the four interventions, approximately 60 students in three sections of introductory physical geology were expected to represent and evaluate scientific data, make evidence-based claims about the data trends, use those claims to express conceptual models, and use their models to analyze societal challenges. Throughout each step of the laboratory exercise students were asked to justify their claims, models, and data representations using evidence and through the use of argumentation with peers. Cognitive apprenticeship was the foundation for instruction used to scaffold students so that in the first exercise they are given a partially completed model and in the last exercise students are asked to generate a conceptual model on their own. Student artifacts, including representation of earth systems, representation of scientific data, verbal and written explanations of models and scientific arguments, and written solutions to specific societal issues or environmental problems surrounding earth systems, were analyzed through the use of a rubric that modeled authentic expertise and students were sorted into three categories. Written artifacts were examined to identify student argumentation and justifications of solutions through the use of evidence and reasoning. Higher scoring students justified their solutions through evidence-based claims, while lower scoring students typically justified their solutions using anecdotal evidence, emotional ideologies, and naive and incomplete conceptions of earth systems.

  12. Alignment Tool For Inertia Welding

    NASA Technical Reports Server (NTRS)

    Snyder, Gary L.

    1991-01-01

    Compact, easy-to-use tool aligns drive bar of inertia welder over hole in stub. Ensures drive bar concentric to hole within 0.002 in. (0.051 mm.). Holds two batteries and light bulb. Electrical circuit completed, providing current to bulb when pin in contact with post. When pin centered in post hole, it does not touch post, and lamp turns off. Built for use in making repair welds on liquid-oxygen-injector posts in Space Shuttle main engine. Version having suitably modified dimensions used to facilitate alignment in other forests of post.

  13. XUV ionization of aligned molecules

    SciTech Connect

    Kelkensberg, F.; Siu, W.; Gademann, G.; Rouzee, A.; Vrakking, M. J. J.; Johnsson, P.; Lucchini, M.; Lucchese, R. R.

    2011-11-15

    New extreme-ultraviolet (XUV) light sources such as high-order-harmonic generation (HHG) and free-electron lasers (FELs), combined with laser-induced alignment techniques, enable novel methods for making molecular movies based on measuring molecular frame photoelectron angular distributions. Experiments are presented where CO{sub 2} molecules were impulsively aligned using a near-infrared laser and ionized using femtosecond XUV pulses obtained by HHG. Measured electron angular distributions reveal contributions from four orbitals and the onset of the influence of the molecular structure.

  14. Measurements of magnetic field alignment

    SciTech Connect

    Kuchnir, M.; Schmidt, E.E.

    1987-11-06

    The procedure for installing Superconducting Super Collider (SSC) dipoles in their respective cryostats involves aligning the average direction of their field with the vertical to an accuracy of 0.5 mrad. The equipment developed for carrying on these measurements is described and the measurements performed on the first few prototypes SSC magnets are presented. The field angle as a function of position in these 16.6 m long magnets is a characteristic of the individual magnet with possible feedback information to its manufacturing procedure. A comparison of this vertical alignment characteristic with a magnetic field intensity (by NMR) characteristic for one of the prototypes is also presented. 5 refs., 7 figs.

  15. The alignment-distribution graph

    NASA Technical Reports Server (NTRS)

    Chatterjee, Siddhartha; Gilbert, John R.; Schreiber, Robert

    1993-01-01

    Implementing a data-parallel language such as Fortran 90 on a distributed-memory parallel computer requires distributing aggregate data objects (such as arrays) among the memory modules attached to the processors. The mapping of objects to the machine determines the amount of residual communication needed to bring operands of parallel operations into alignment with each other. We present a program representation called the alignment distribution graph that makes these communication requirements explicit. We describe the details of the representation, show how to model communication cost in this framework, and outline several algorithms for determining object mappings that approximately minimize residual communication.

  16. The alignment-distribution graph

    NASA Technical Reports Server (NTRS)

    Chatterjee, Siddhartha; Gilbert, John R.; Schreiber, Robert

    1993-01-01

    Implementing a data-parallel language such as Fortran 90 on a distributed-memory parallel computer requires distributing aggregate data objects (such as arrays) among the memory modules attached to the processors. The mapping of objects to the machine determines the amount of residual communication needed to bring operands of parallel operations into alignment with each other. We present a program representation called the alignment-distribution graph that makes these communication requirements explicit. We describe the details of the representation, show how to model communication cost in this framework, and outline several algorithms for determining object mappings that approximately minimize residual communication.

  17. XUV ionization of aligned molecules

    NASA Astrophysics Data System (ADS)

    Kelkensberg, F.; Rouzée, A.; Siu, W.; Gademann, G.; Johnsson, P.; Lucchini, M.; Lucchese, R. R.; Vrakking, M. J. J.

    2011-11-01

    New extreme-ultraviolet (XUV) light sources such as high-order-harmonic generation (HHG) and free-electron lasers (FELs), combined with laser-induced alignment techniques, enable novel methods for making molecular movies based on measuring molecular frame photoelectron angular distributions. Experiments are presented where CO2 molecules were impulsively aligned using a near-infrared laser and ionized using femtosecond XUV pulses obtained by HHG. Measured electron angular distributions reveal contributions from four orbitals and the onset of the influence of the molecular structure.

  18. Quantum Interference in Aligned Molecules

    NASA Astrophysics Data System (ADS)

    Vozzi, C.; Benedetti, E.; Calegari, F.; Caumes, J.-P.; Sansone, G.; Stagira, S.; Nisoli, M.; Torres, R.; Heesel, E.; Kajumba, N.; Marangos, J. P.; Altucci, C.; Velotta, R.

    High-order harmonic generation (HHG) in aligned molecules is an important area in strong field ultrafast physics [1]-[3]. It has been shown that the dependence of HHG on the molecular structure can give new insights into measuring molecular structure on a subfemtosecond timescale [3]. A unique aspect of HHG in a simple molecular system is the possibility to observe quantum interference phenomena related to the shape of the molecular wavefimction [4],[5]. Recently this effect has been observed in HHG from aligned CO2 molecules by Kanai et al. [6] and by Vozzi et al. [7].

  19. A Comparison of Thailand and New Zealand Students' Ideas about Energy Related to Technological and Societal Issues

    ERIC Educational Resources Information Center

    Yuenyong, Chokchai; Jones, Alister; Yutakom, Naruemon

    2008-01-01

    This study is a cross-cultural comparison between the ideas of 49 Thai Grade 9 students and the 30 New Zealand Grade 9 students (approximately 15 years old), about energy related to technological and societal issues. Students' ideas were explored using the Questionnaire for exploring Students' ideas about Energy, Technological, and Societal issues…

  20. Alignment of protein sequences by their profiles.

    PubMed

    Marti-Renom, Marc A; Madhusudhan, M S; Sali, Andrej

    2004-04-01

    The accuracy of an alignment between two protein sequences can be improved by including other detectably related sequences in the comparison. We optimize and benchmark such an approach that relies on aligning two multiple sequence alignments, each one including one of the two protein sequences. Thirteen different protocols for creating and comparing profiles corresponding to the multiple sequence alignments are implemented in the SALIGN command of MODELLER. A test set of 200 pairwise, structure-based alignments with sequence identities below 40% is used to benchmark the 13 protocols as well as a number of previously described sequence alignment methods, including heuristic pairwise sequence alignment by BLAST, pairwise sequence alignment by global dynamic programming with an affine gap penalty function by the ALIGN command of MODELLER, sequence-profile alignment by PSI-BLAST, Hidden Markov Model methods implemented in SAM and LOBSTER, pairwise sequence alignment relying on predicted local structure by SEA, and multiple sequence alignment by CLUSTALW and COMPASS. The alignment accuracies of the best new protocols were significantly better than those of the other tested methods. For example, the fraction of the correctly aligned residues relative to the structure-based alignment by the best protocol is 56%, which can be compared with the accuracies of 26%, 42%, 43%, 48%, 50%, 49%, 43%, and 43% for the other methods, respectively. The new method is currently applied to large-scale comparative protein structure modeling of all known sequences. PMID:15044736

  1. Development of deterrence strategies

    SciTech Connect

    Pilgrim, M.K.; Fineberg, M.L.; Ely, R.S.; Smith, M.A.; Mengel, R.W.

    1981-09-01

    The development of deterrence strategies requires an in-depth understanding of the characteristics and decision-making processes of all categories of potential adversaries to DOE facilities and programs. A second component needed is recognition of the strengths and vulnerabilities of the safeguards system surrounding the target since each contributes significantly to the adversaries' perception of risk and attractiveness associated with that target. An understanding of the local and national societal conditions which might create or exacerbate terrorism, criminal activity or other types of malevolent action is a third analytic element necessary to support develoment of deterrents. Knowledge of the dynamics of these three components provides the analytical basis upon which initial definition of the types and approaches to deterrence can be arrived at. The analyses and results described in this report address each of these components and provide a solid conceptual, qualitative and quantitative base from which to develop specific deterrence strategies. 16 figures, 8 tables.

  2. Cost-Effectiveness Analysis of the Bivalent and Quadrivalent Human Papillomavirus Vaccines from a Societal Perspective in Colombia

    PubMed Central

    Aponte-González, Johanna; Fajardo-Bernal, Luisa; Diaz, Jorge; Eslava-Schmalbach, Javier; Gamboa, Oscar; Hay, Joel W.

    2013-01-01

    Objective To compare costs and effectiveness of three strategies used against cervical cancer (CC) and genital warts: (i) Screening for CC; (ii) Bivalent Human Papillomavirus (HPV) 16/18 vaccine added to screening; (iii) Quadrivalent HPV 6/11/16/18 vaccine added to screening. Methods A Markov model was designed in order to simulate the natural history of the disease from 12 years of age (vaccination) until death. Transition probabilities were selected or adjusted to match the HPV infection profile in Colombia. A systematic review was undertaken in order to derive efficacy values for the two vaccines as well as for the operational characteristics of the cytology test. The societal perspective was used. Effectiveness was measured in number of averted Disability Adjusted Life Years (DALYS). Results At commercial prices reported for 2010 the two vaccines were shown to be non-cost-effective alternatives when compared with the existing screening strategy. Sensitivity analyses showed that results are affected by the cost of vaccines and their efficacy values, making it difficult to determine with certainty which of the two vaccines has the best cost-effectiveness profile. To be ‘cost-effective’ vaccines should cost between 141 and 147 USD (Unite States Dollars) per vaccinated girl at the most. But at lower prices such as those recommended by WHO or the price of other vaccines in Colombia, HPV vaccination could be considered very cost-effective. Conclusions HPV vaccination could be a convenient alternative for the prevention of CC in Colombia. However, the price of the vaccine should be lower for this vaccination strategy to be cost-effective. It is also important to take into consideration the willingness to pay, budgetary impact, and program implications, in order to determine the relevance of a vaccination program in this country, as well as which vaccine should be selected for use in the program. PMID:24260441

  3. Cosmic rays and grain alignment

    NASA Astrophysics Data System (ADS)

    Lazarian, A.; Roberge, W. G.

    1997-06-01

    The recent detection of interstellar polarization in the solid CO feature near 4.67mum shows that CO-mantled grains can be aligned in cold molecular clouds. These observations conflict with a theory of grain alignment which attributes the polarization in molecular clouds to the effects of cosmic rays: according to this theory, oblate spheroidal grains with H_2O- and CO_2-dominated ice mantles are spun up to suprathermal energies by molecular evaporation from cosmic ray impact sites, but spin-up does not occur for CO-mantled grains. Motivated by this conflict, we re-examine the effects of cosmic rays on the alignment of icy grains. We show that the systematic torques produced by cosmic rays are insufficient to cause suprathermal spin. In principle, the random torques due to cosmic rays can enhance the efficiency of Davis-Greenstein alignment by raising the grain rotational temperature. However, a significant enhancement would require cosmic ray fluxes 6-7 orders of magnitude larger than the flux in a typical cold cloud.

  4. Laser-Beam-Alignment Controller

    NASA Technical Reports Server (NTRS)

    Krasowski, M. J.; Dickens, D. E.

    1995-01-01

    In laser-beam-alignment controller, images from video camera compared to reference patterns by fuzzy-logic pattern comparator. Results processed by fuzzy-logic microcontroller, which sends control signals to motor driver adjusting lens and pinhole in spatial filter.

  5. Tonal Alignment in Irish Dialects

    ERIC Educational Resources Information Center

    Dalton, Martha; Ni Chasaide, Ailbhe

    2005-01-01

    A comparison of the contour alignment of nuclear and initial prenuclear accents was carried out for the Irish dialects of Gaoth Dobhair in Ulster (GD-U) and Cois Fharraige in Connaught (CF-C). This was done across conditions where the number of unstressed syllables following the nuclear and preceding the initial prenuclear accents was varied from…

  6. Earth Observation in Environmental and Societal Impacts of Mineral Resources Exploitation

    NASA Astrophysics Data System (ADS)

    Chevrel, Stephane

    Several national and international initiatives, both from the private or the institutional sectors, arised to address the sustainable development of the extractive industry and the reduction of its environmental footprint. Meanwhile, the extractive industry is facing increasing environmental and societal pressures, being regulatory or not, during all phases of a project, from exploration to exploitation and closure. The social acceptability of a project is among the major key issues to be dealt with. The EO-MINERS project (Earth Observation for Monitoring and Observing Environmental and Societal Impacts of Mineral Resources Exploration and Exploitation) is a newly EU funded Research and Technological Development project started in February 2010. EO-MINERS scientific and technical objectives are to: i) assess policy requirements at macro (public) and micro (mining companies) levels and define environmental, socio-economic, societal and sustainable development criteria and indicators to be possibly dealt using EO (Earth Observation); ii) use existing EO knowledge and carry out new developments on demonstration sites to further demonstrate the capabilities of integrated EO-based methods and tools in monitoring, managing and contributing reducing the environmental and societal footprints of the extractive industry during all phases of a mining project, from the exploration to the exploitation and closure stages; iii) contribute making reliable and objective information about affected ecosystems, populations and societies, to serve as a basis for a sound "trialogue" between industrialists, governmental organisations and stakeholders. EO-MINERS also is designed to embed the outcomes of the project firmly in the GEO process through a review the existing GEO Tasks covering the 9 societal benefit and 5 transverse areas defined by GEO work plan 2007-2009. This analysis will be used to identify synergies and gaps between EO-MINERS and GEO, with the aim of mapping mining and environmental observa-tion systems into the 9 GEOSS Societal Benefit Areas, identifying EO-MINERS contributions to existing GEOSS targets and defining new, EO-MINERS activities in support of GEOSS. EO-MINERS will run a minerals workshop with GEO members and/or the GEO Secretariat.

  7. Minimal-effort planning of active alignment processes for beam-shaping optics

    NASA Astrophysics Data System (ADS)

    Haag, Sebastian; Schranner, Matthias; Müller, Tobias; Zontar, Daniel; Schlette, Christian; Losch, Daniel; Brecher, Christian; Roßmann, Jürgen

    2015-03-01

    In science and industry, the alignment of beam-shaping optics is usually a manual procedure. Many industrial applications utilizing beam-shaping optical systems require more scalable production solutions and therefore effort has been invested in research regarding the automation of optics assembly. In previous works, the authors and other researchers have proven the feasibility of automated alignment of beam-shaping optics such as collimation lenses or homogenization optics. Nevertheless, the planning efforts as well as additional knowledge from the fields of automation and control required for such alignment processes are immense. This paper presents a novel approach of planning active alignment processes of beam-shaping optics with the focus of minimizing the planning efforts for active alignment. The approach utilizes optical simulation and the genetic programming paradigm from computer science for automatically extracting features from a simulated data basis with a high correlation coefficient regarding the individual degrees of freedom of alignment. The strategy is capable of finding active alignment strategies that can be executed by an automated assembly system. The paper presents a tool making the algorithm available to end-users and it discusses the results of planning the active alignment of the well-known assembly of a fast-axis collimator. The paper concludes with an outlook on the transferability to other use cases such as application specific intensity distributions which will benefit from reduced planning efforts.

  8. Effect of allergist intervention on patient-centered and societal outcomes: allergists as leaders, innovators, and educators.

    PubMed

    Zeiger, R S; Schatz, M

    2000-12-01

    Atopic disorders, which afflict millions of Americans and hundreds of millions worldwide, are at epidemic levels with concomitant increases in morbidity and mortality. Environmental and lifestyle changes over the past three to five decades are proposed causes for this pandemic and as such present major burdens to reverse. The scope of allergy practice bridges directly on this challenge. Allergy as a specialty is a major leader in developing effective strategies to confront this epidemic. Allergists have made major contributions to the understanding of the risk factors, immunology, pathophysiology, immunomodulation, and prevention of atopic and immunologic disorders. Allergist epidemiologists and clinicians have helped develop and implement national and international guidelines in the recognition, management, and prevention of asthma and rhinitis. Allergist clinical researchers are active in (1) outcomes research that demonstrates convincingly the value of allergy as a specialty in asthma, allergic rhinitis, anaphylaxis, drug and food allergy, and other atopic disorders, (2) National Institutes of Health clinical trials that will form the basis for the future treatment of asthma and allergic disease, and (3) pharmaceutical trials that evaluate new, effective, and safe medication to treat atopic disease. Allergist educators, comprising academic and practicing allergists, supported by allied health professionals, national associations, and affiliated lay organizations, provide comprehensive education to fellows, residents, colleague physicians, media, the public, and patients. Documentation of the value of allergists in improving patient-centered and societal outcomes in their core domain, allergy, is the appropriate final topic contribution in the important series "New millennium: The conquest of allergy." PMID:11112881

  9. Forecasting Significant Societal Events Using The Embers Streaming Predictive Analytics System

    PubMed Central

    Katz, Graham; Summers, Kristen; Ackermann, Chris; Zavorin, Ilya; Lim, Zunsik; Muthiah, Sathappan; Butler, Patrick; Self, Nathan; Zhao, Liang; Lu, Chang-Tien; Khandpur, Rupinder Paul; Fayed, Youssef; Ramakrishnan, Naren

    2014-01-01

    Abstract Developed under the Intelligence Advanced Research Project Activity Open Source Indicators program, Early Model Based Event Recognition using Surrogates (EMBERS) is a large-scale big data analytics system for forecasting significant societal events, such as civil unrest events on the basis of continuous, automated analysis of large volumes of publicly available data. It has been operational since November 2012 and delivers approximately 50 predictions each day for countries of Latin America. EMBERS is built on a streaming, scalable, loosely coupled, shared-nothing architecture using ZeroMQ as its messaging backbone and JSON as its wire data format. It is deployed on Amazon Web Services using an entirely automated deployment process. We describe the architecture of the system, some of the design tradeoffs encountered during development, and specifics of the machine learning models underlying EMBERS. We also present a detailed prospective evaluation of EMBERS in forecasting significant societal events in the past 2 years. PMID:25553271

  10. Contributions of societal modernity to cognitive development: a comparison of four cultures.

    PubMed

    Gauvain, Mary; Munroe, Robert L

    2009-01-01

    This study examined how societal changes associated with modernization are related to cognitive development. Data were from 4 cultural communities that represented a broad range of traditional and modern elements: the Garifuna (Belize), Logoli (Kenya), Newars (Nepal), and Samoans (American Samoa). Naturalistic observations and the performances of 3-, 5-, 7-, and 9-year-old children (N = 192) on 7 cognitive measures were examined. Results replicated age-related improvement on all measures. Contributions of modernity were evident in children's play behaviors and cognitive performances, especially in skills related to schooling. Modernization and schooling independently predicted differences on most of the measures. Results are discussed in relation to the Flynn effect, the worldwide increase in cognitive scores across generations, and the ways in which societal modernization may contribute to cognitive development. PMID:19930342

  11. Should a criminal receive a heart transplant? Medical justice vs. societal justice.

    PubMed

    Schneiderman, L J; Jecker, N S

    1996-03-01

    Should the nation provide expensive care and scarce organs to convicted felons? We distinguish between two fields of justice: Medical Justice and Societal Justice. Although there is general acceptance within the medical profession that physicians may distribute limited treatments based solely on potential medical benefits without regard to nonmedical factors, that does not mean that society cannot impose limits based on societal factors. If a society considers the convicted felon to be a full member, then that person would be entitled to at least a "decent minimum" level of care--which might include access to scarce life-saving organs. However, if criminals forfeit their entitlement to the same level of medical care afforded to all members of society, they still would be entitled to a kind of "rudimentary decent minimum" granted to all persons on simple humanitarian grounds. Almost certainly this entitlement would not include access to organ transplants. PMID:8992645

  12. United States societal experiments via the Communications Technology Satellite. [antenna coverage

    NASA Technical Reports Server (NTRS)

    Donoughe, P. L.

    1976-01-01

    The Communications Technology Satellite (CTS) is a cooperative experimental program of the United States and Canadian governments. The CTS uses a high-power transponder at the frequencies of 14/12 GHz for two-way television and voice communication. The United States and Canada have agreed to share equally in the use of CTS. The U.S. program includes a variety of societal experiments. The ground stations for these experiments are located from the Atlantic to the Pacific. The satellite communications capabilities and the antenna coverage for the U.S. are summarized. Emphasis is placed on the U.S. societal experiments in the areas of education, health care, and community and special services; nine separate experiments are discussed.

  13. Media use and children's perceptions of societal threat and personal vulnerability.

    PubMed

    Comer, Jonathan S; Furr, Jami M; Beidas, Rinad S; Babyar, Heather M; Kendall, Philip C

    2008-07-01

    This study examined children's media use (i.e., amount of television and Internet usage) and relationships to children's perceptions of societal threat and personal vulnerability. The sample consisted of 90 community youth aged 7 to 13 years (M = 10.8; 52.2% male) from diverse economic backgrounds. Analyses found children's television use to be associated with elevated perceptions of personal vulnerability to world threats (i.e., crime, terrorism, earthquakes, hurricanes, and floods). An interactive model of television use and child anxiety in accounting for children's personal threat perceptions was supported, in which the strength of television consumption in predicting children's personal threat perceptions was greater for children with greater anxiety. Relationships were found neither between children's Internet use and threat perceptions nor between media use and perceptions of societal threat. PMID:18645752

  14. Societal and ethical issues in human biomonitoring – a view from science studies

    PubMed Central

    Bauer, Susanne

    2008-01-01

    Background Human biomonitoring (HBM) has rapidly gained importance. In some epidemiological studies, the measurement and use of biomarkers of exposure, susceptibility and disease have replaced traditional environmental indicators. While in HBM, ethical issues have mostly been addressed in terms of informed consent and confidentiality, this paper maps out a larger array of societal issues from an epistemological perspective, i.e. bringing into focus the conditions of how and what is known in environmental health science. Methods In order to analyse the effects of HBM and the shift towards biomarker research in the assessment of environmental pollution in a broader societal context, selected analytical frameworks of science studies are introduced. To develop the epistemological perspective, concepts from "biomedical platform sociology" and the notion of "epistemic cultures" and "thought styles" are applied to the research infrastructures of HBM. Further, concepts of "biocitizenship" and "civic epistemologies" are drawn upon as analytical tools to discuss the visions and promises of HBM as well as related ethical problematisations. Results In human biomonitoring, two different epistemological cultures meet; these are environmental science with for instance pollution surveys and toxicological assessments on the one hand, and analytical epidemiology investigating the association between exposure and disease in probabilistic risk estimation on the other hand. The surveillance of exposure and dose via biomarkers as envisioned in HBM is shifting the site of exposure monitoring to the human body. Establishing an HBM platform faces not only the need to consider individual decision autonomy as an ethics issue, but also larger epistemological and societal questions, such as the mode of evidence demanded in science, policy and regulation. Conclusion The shift of exposure monitoring towards the biosurveillance of human populations involves fundamental changes in the ways environment, health and disease are conceptualised; this may lead to an individualisation of responsibilities for health risks and preventive action. Attention to the conditions of scientific knowledge generation and to their broader societal context is critical in order to make HBM contribute to environmental justice. PMID:18541064

  15. The total assessment profile, volume 1. [including societal impact cost effectiveness, and economic analysis

    NASA Technical Reports Server (NTRS)

    Leininger, G.; Jutila, S.; King, J.; Muraco, W.; Hansell, J.; Lindeen, J.; Franckowiak, E.; Flaschner, A.

    1975-01-01

    A methodology is described for the evaluation of societal impacts associated with the implementation of a new technology. Theoretical foundations for the methodology, called the total assessment profile, are established from both the economic and social science perspectives. The procedure provides for accountability of nonquantifiable factors and measures through the use of a comparative value matrix by assessing the impacts of the technology on the value system of the society.

  16. Balancing consumer and societal requirements for sheep meat production: an Australasian perspective.

    PubMed

    Ferguson, D M; Schreurs, N M; Kenyon, P R; Jacob, R H

    2014-11-01

    Although there has been a decline in sheep numbers in Australia and New Zealand, both countries remain significant producers and exporters of sheep meat. The ongoing demand for more sustainable and ethical animal farming systems and practices requires sheep production industries to be both vigilant and responsive to consumer and the broader societal needs. Demonstration of continuous improvement in animal welfare is paramount and the welfare risks and challenges confronting Australasian sheep industries now and into the future are discussed. PMID:25015875

  17. The interplay between societal concerns and the regulatory frame on GM crops in the European Union.

    PubMed

    Devos, Yann; Reheul, Dirk; De Waele, Danny; Van Speybroeck, Linda

    2006-01-01

    Recapitulating how genetic modification technology and its agro-food products aroused strong societal opposition in the European Union, this paper demonstrates how this opposition contributed to shape the European regulatory frame on GM crops. More specifically, it describes how this opposition contributed to a de facto moratorium on the commercialization of new GM crop events in the end of the nineties. From this period onwards, the regulatory frame has been continuously revised in order to slow down further erosion of public and market confidence. Various scientific and technical reforms were made to meet societal concerns relating to the safety of GM crops. In this context, the precautionary principle, environmental post-market monitoring and traceability were adopted as ways to cope with scientific uncertainties. Labeling, traceability, co-existence and public information were installed in an attempt to meet the general public request for more information about GM agro-food products, and the specific demand to respect the consumers' and farmers' freedom of choice. Despite these efforts, today, the explicit role of public participation and/or ethical consultation during authorization procedures is at best minimal. Moreover, no legal room was created to progress to an integral sustainability evaluation during market procedures. It remains to be seen whether the recent policy shift towards greater transparency about value judgments, plural viewpoints and scientific uncertainties will be one step forward in integrating ethical concerns more explicitly in risk analysis. As such, the regulatory frame stands open for further interpretation, reflecting in various degrees a continued interplay with societal concerns relating to GM agro-food products. In this regard, both societal concerns and diversely interpreted regulatory criteria can be inferred as signaling a request - and even a quest - to render more explicit the broader-than-scientific dimension of the actual risk analysis. PMID:17445510

  18. Lost in Translation: Aligning Strategies for Research in New Zealand

    ERIC Educational Resources Information Center

    Billot, Jennie; Codling, Andrew

    2012-01-01

    In New Zealand, the funding of higher education research has been influenced by revised policy-driven imperatives. Amidst the institutional reactions to new criteria for governmental funding, individual academics are being asked to increase their productivity in order for their employing institution to access public funding. For this to occur,…

  19. CMS alignment and calibration framework

    NASA Astrophysics Data System (ADS)

    Edelhoff, Matthias; CMS Collaboration

    2012-12-01

    Precise and prompt alignment and calibration will be crucial to the performance of the CMS detector. A software and computing infrastructure has been commissioned, which accomplishes both tasks in a swift and reliable manner. First, incoming data from the experiment is processed and skimmed automatically at the Tier-0 site. Reduction of data size is of prime interest in this stage, to ensure efficient use of computing facilities and fast turnaround-times. Second, a versatile computing farm (CERN Analysis Farm) enables a fast execution of the alignment and calibration workflows. Both steps are coordinated and carried out for a large number of interdependent processes. The resulting database payloads are used for all subsequent reconstruction steps, providing optimised measurement precision to physics analysis. The framework is described alongside to the validation of its implementation. To this end some results using cosmic data taken in 2008 are shown.

  20. Prism Window for Optical Alignment

    NASA Technical Reports Server (NTRS)

    Tang, Hong

    2008-01-01

    A prism window has been devised for use, with an autocollimator, in aligning optical components that are (1) required to be oriented parallel to each other and/or at a specified angle of incidence with respect to a common optical path and (2) mounted at different positions along the common optical path. The prism window can also be used to align a single optical component at a specified angle of incidence. Prism windows could be generally useful for orienting optical components in manufacture of optical instruments. "Prism window" denotes an application-specific unit comprising two beam-splitter windows that are bonded together at an angle chosen to obtain the specified angle of incidence.

  1. Aligned mesoporous architectures and devices.

    SciTech Connect

    Brinker, C. Jeffrey; Lu, Yunfeng

    2011-03-01

    This is the final report for the Presidential Early Career Award for Science and Engineering - PECASE (LDRD projects 93369 and 118841) awarded to Professor Yunfeng Lu (Tulane University and University of California-Los Angeles). During the last decade, mesoporous materials with tunable periodic pores have been synthesized using surfactant liquid crystalline as templates, opening a new avenue for a wide spectrum of applications. However, the applications are somewhat limited by the unfavorabe pore orientation of these materials. Although substantial effort has been devoted to align the pore channels, fabrication of mesoporous materials with perpendicular pore channels remains challenging. This project focused on fabrication of mesoporous materials with perpendicularly aligned pore channels. We demonstrated structures for use in water purification, separation, sensors, templated synthesis, microelectronics, optics, controlled release, and highly selective catalysts.

  2. Emerging research in micro and nano systems: opportunities and challenges for societal impact

    NASA Astrophysics Data System (ADS)

    Gianchandani, Yogesh B.

    2010-02-01

    In just a few decades, micro and nano technologies have changed the way that we live - how we work and communicate; the food and medicine that we consume; the clothing that we use; and the entertainment that we seek. While these technologies are being actively investigated in several research communities, the potential for continued societal impact is constrained by resources available for system-level research. Given the long time-lines and levels of investment that are typically necessary to develop functional systems, strategic prioritization of research directions from the perspective of societal needs can be helpful. This paper outlines the findings of an NSF-sponsored road-mapping workshop that was held in 2009, with the intention of initiating a conversation about the opportunities and challenges for micro and nano systems. Four areas of need were discussed: environmental sensing; health care; infrastructure monitoring; and energy alternatives. Possible research trajectories were identified by envisioning technological goals for the year 2040, and linking these to horizons for 2015 and 2025. This paper also provides few examples of current research in each of the four application domains. It is noted that a systems perspective can help to keep the research focused, accelerating and amplifying the societal gain with available resources. Practical and affordable solutions at the system level will require partnerships between specialists, and also between academia and industry.

  3. SIM Lite: ground alignment of the instrument

    NASA Astrophysics Data System (ADS)

    Dekens, Frank G.; Goullioud, Renaud; Nicaise, Fabien; Kuan, Gary; Morales, Mauricio

    2010-07-01

    We present the start of the ground alignment plan for the SIM Lite Instrument. We outline the integration and alignment of the individual benches on which all the optics are mounted, and then the alignment of the benches to form the Science and Guide interferometers. The Instrument has a guide interferometer with only a 40 arc-seconds field of regard, and 200 arc-seconds of alignment adjustability. This requires each sides of the interferometer to be aligned to a fraction of that, while at the same time be orthogonal to the baseline defined by the External Metrology Truss. The baselines of the Science and Guide interferometers must also be aligned to be parallel. The start of these alignment plans is captured in a SysML Instrument System model, in the form of activity diagrams. These activity diagrams are then related to the hardware design and requirements. We finish with future plans for the alignment and integration activities and requirements.

  4. B-MIC: An Ultrafast Three-Level Parallel Sequence Aligner Using MIC.

    PubMed

    Cui, Yingbo; Liao, Xiangke; Zhu, Xiaoqian; Wang, Bingqiang; Peng, Shaoliang

    2016-03-01

    Sequence alignment is the central process for sequence analysis, where mapping raw sequencing data to reference genome. The large amount of data generated by NGS is far beyond the process capabilities of existing alignment tools. Consequently, sequence alignment becomes the bottleneck of sequence analysis. Intensive computing power is required to address this challenge. Intel recently announced the MIC coprocessor, which can provide massive computing power. The Tianhe-2 is the world's fastest supercomputer now equipped with three MIC coprocessors each compute node. A key feature of sequence alignment is that different reads are independent. Considering this property, we proposed a MIC-oriented three-level parallelization strategy to speed up BWA, a widely used sequence alignment tool, and developed our ultrafast parallel sequence aligner: B-MIC. B-MIC contains three levels of parallelization: firstly, parallelization of data IO and reads alignment by a three-stage parallel pipeline; secondly, parallelization enabled by MIC coprocessor technology; thirdly, inter-node parallelization implemented by MPI. In this paper, we demonstrate that B-MIC outperforms BWA by a combination of those techniques using Inspur NF5280M server and the Tianhe-2 supercomputer. To the best of our knowledge, B-MIC is the first sequence alignment tool to run on Intel MIC and it can achieve more than fivefold speedup over the original BWA while maintaining the alignment precision. PMID:26358141

  5. Semantic alignment and number comparison.

    PubMed

    Campbell, Jamie I D; Sacher, Sean G

    2012-01-01

    Are the quantity representations activated by Arabic digits influenced by semantic context? We developed a novel paradigm to examine semantic alignment effects (e.g., Bassok et al. in J Exp Psychol Learn Mem Cogn 34:343-352, 2008) in number comparison. A horizontal word pair (either less more or few many) appeared for 480 ms to prime either relative magnitude (less more) or quantity (few many). Then a horizontal pair of single digits that were either successors (near) or differed by at least four (far) appeared above the word pair. Participants indicated verbally whether or not the word and digit pairs were congruent with respect to left-to-right ascending or descending relative magnitude. The RT advantage for far number pairs compared to near pairs (the distance effect) was greater with magnitude primes (81 ms) than quantity primes (17 ms), demonstrating a semantic alignment effect. This effect disappeared in Experiment 2 in which participants received identical stimuli but named the larger of the two digits and were free to ignore the primes. Nonetheless, mean RT in Experiment 2 was faster with prime and target pairs both ascending or both descending, but only with quantity primes. This prime-dependent order-congruity effect suggests that semantic alignment with respect to numerical order affected number comparison in Experiment 2. The results thereby demonstrate that number comparison exhibits task-dependent semantic alignment effects and recruits distinct numerical representations as a function of semantic context (e.g., Cohen Kadosh and Walsh in Behav Brain Sci 32:313-373, 2009). PMID:21461771

  6. Fiber alignment apparatus and method

    DOEpatents

    Kravitz, S.H.; Warren, M.E.; Snipes, M.B. Jr.; Armendariz, M.G.; Word, J.C. V

    1997-08-19

    A fiber alignment apparatus includes a micro-machined nickel spring that captures and locks arrays of single mode fibers into position. The design consists of a movable nickel leaf shaped spring and a fixed pocket where fibers are held. The fiber is slid between the spring and a fixed block, which tensions the spring. When the fiber reaches the pocket, it automatically falls into the pocket and is held by the pressure of the leaf spring. 8 figs.

  7. Fiber alignment apparatus and method

    DOEpatents

    Kravitz, Stanley H. (Placitas, NM); Warren, Mial Evans (Albuquerque, NM); Snipes, Jr., Morris Burton (Albuquerque, NM); Armendariz, Marcelino Guadalupe (Albuquerque, NM); Word, V., James Cole (Albuqueruqe, NM)

    1997-01-01

    A fiber alignment apparatus includes a micro-machined nickel spring that captures and locks arrays of single mode fibers into position. The design consists of a movable nickel leaf shaped spring and a fixed pocket where fibers are held. The fiber is slid between the spring and a fixed block, which tensions the spring. When the fiber reaches the pocket, it automatically falls into the pocket and is held by the pressure of the leaf spring.

  8. Alignment in double capture processes

    SciTech Connect

    Moretto-Capelle, P.; Benhenni, M.; Bordenave-Montesquieu, A.; Benoit-Cattin, P.; Gleizes, A. )

    1993-06-05

    The electron spectra emitted when a double capture occurs in N[sup 7+]+He and Ne[sup 8+]+He systems at 10 qkeV collisional energy, allow us to determine the angular distributions of the 3[ell]3[ell] [prime] lines through a special spectra fitting procedure which includes interferences between neighbouring states. It is found that the doubly excited states populated in double capture processes are generally aligned.

  9. Conflict and fear over the impacts of science and technology may retard, or may hasten, societal progress

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Rapidly changing societal and individual values impact the course of man's future with accompanying conflict, tension and alienation. Conflict and fear over the impacts of science and technology may retard, or may hasten, societal progress. The broadening of the concept of equality of opportunity to an equality of outcome manifests itself by distributing the rewards of society based not on performance but simply on membership in the society. It is concluded that institutional failure caused by organizational and bureaucratic ineffectiveness inhibits change necessary for the solution of societal problems.

  10. Vertically aligned carbon based varactors

    NASA Astrophysics Data System (ADS)

    Ghavanini, Farzan A.; Enoksson, Peter; Bengtsson, Stefan; Lundgren, Per

    2011-07-01

    This paper gives an assessment of vertically aligned carbon based varactors and validates their potential for future applications. The varactors discussed here are nanoelectromechanical devices which are based on either vertically aligned carbon nanofibers or vertically aligned carbon nanotube arrays. A generic analytical model for parallel plate nanoelectromechanical varactors based on previous works is developed and is used to formulate a universal expression for their voltage-capacitance relation. Specific expressions for the nanofiber based and the nanotube based varactors are then derived separately from the generic model. This paper also provides a detailed review on the fabrication of carbon based varactors and pays special attention to the challenges in realizing such devices. Finally, the performance of the carbon based varactor is assessed in accordance with four criteria: the static capacitance, the tuning ratio, the quality factor, and the operating voltage. Although the reported performance is still far inferior to other varactor technologies, our prognosis which stems from the analytical model shows a promise of a high quality factor as well as a potential for high power handling for carbon based varactors.

  11. Aligning Plasma-Arc Welding Oscillations

    NASA Technical Reports Server (NTRS)

    Norris, Jeff; Fairley, Mike

    1989-01-01

    Tool aids in alignment of oscillator probe on variable-polarity plasma-arc welding torch. Probe magnetically pulls arc from side to side as it moves along joint. Tensile strength of joint depends on alignment of weld bead and on alignment of probe. Operator installs new tool on front of torch body, levels it with built-in bubble glass, inserts probe in slot on tool, and locks probe in place. Procedure faster and easier and resulting alignment more accurate and repeatable.

  12. Jig Aligns Shadow Mask On CCD

    NASA Technical Reports Server (NTRS)

    Matus, Carlos V.

    1989-01-01

    Alignment viewed through microscope. Alignment jig positions shadow mask on charge-coupled device (CCD) so metal film deposited on it precisely. Allows CCD package to be inserted and removed without disturbing alignment of mask. Holds CCD packages securely and isolates it electrostatically while providing electrical contact to each of its pins. When alignment jig assembled with CCD, used to move mask under micrometer control.

  13. Alignment 2.0: Strategic Use of New Internet Technologies in Government

    ERIC Educational Resources Information Center

    Meijer, Albert; Thaens, Marcel

    2010-01-01

    This paper challenges the view that strategies for using Web 2.0 should primarily be based upon technological characteristics. The value of the organizational strategic alignment approach for developing specific operational Web 2.0 strategies for government organizations is explored both theoretically and empirically. On the basis of a review of…

  14. Physician-Hospital Alignment in Orthopedic Surgery.

    PubMed

    Bushnell, Brandon D

    2015-09-01

    The concept of "alignment" between physicians and hospitals is a popular buzzword in the age of health care reform. Despite their often tumultuous histories, physicians and hospitals find themselves under increasing pressures to work together toward common goals. However, effective alignment is more than just simple cooperation between parties. The process of achieving alignment does not have simple, universal steps. Alignment will differ based on individual situational factors and the type of specialty involved. Ultimately, however, there are principles that underlie the concept of alignment and should be a part of any physician-hospital alignment efforts. In orthopedic surgery, alignment involves the clinical, administrative, financial, and even personal aspects of a surgeon's practice. It must be based on the principles of financial interest, clinical authority, administrative participation, transparency, focus on the patient, and mutual necessity. Alignment can take on various forms as well, with popular models consisting of shared governance and comanagement, gainsharing, bundled payments, accountable care organizations, and other methods. As regulatory and financial pressures continue to motivate physicians and hospitals to develop alignment relationships, new and innovative methods of alignment will also appear. Existing models will mature and evolve, with individual variability based on local factors. However, certain trends seem to be appearing as time progresses and alignment relationships deepen, including regional and national collaboration, population management, and changes in the legal system. This article explores the history, principles, and specific methods of physician-hospital alignment and its critical importance for the future of health care delivery. PMID:26375539

  15. Automated Alignment And Inspection Of Duct Welds

    NASA Technical Reports Server (NTRS)

    Cross, George S.

    1993-01-01

    Machine vision system being developed for use in aligning ends of two round ducts before welding ends together and inspecting welded ducts for alignment after welding. System makes consistent, objective measurements quickly. Improves quality and reliability of welds, reduces need for rework, and reduces alignment and inspection time, thereby reducing cost of manufacture.

  16. Quick Check Of Butt-Weld Alignment

    NASA Technical Reports Server (NTRS)

    Smith, Matthew A.

    1990-01-01

    Proposed tool measures alignments of plates before butt-welded. Provides nearly instantaneous check on alignment, thereby facilitating repetitive measurements along length of weld joint. Reduces risk of contamination of weld from dirty measuring tools. Middle photodetector indicates acceptable alignment when position of transmitter fiber preciously matches that of center receiver fiber. If plates offset, other photodetectors signal misalignment.

  17. Aligning Performance: Improving People, Systems, and Organizations.

    ERIC Educational Resources Information Center

    Langdon, Danny

    Performance is the actual work that is done to assure that an organization achieves its mission, and aligning that performance assures that the path to the mission is harmonious. Alignment exists when all people involved understand the dimensions of the work and want to achieve and improve alignment. This book presents the "Language of Work" model…

  18. Vertically aligned nanostructure scanning probe microscope tips

    DOEpatents

    Guillorn, Michael A.; Ilic, Bojan; Melechko, Anatoli V.; Merkulov, Vladimir I.; Lowndes, Douglas H.; Simpson, Michael L.

    2006-12-19

    Methods and apparatus are described for cantilever structures that include a vertically aligned nanostructure, especially vertically aligned carbon nanofiber scanning probe microscope tips. An apparatus includes a cantilever structure including a substrate including a cantilever body, that optionally includes a doped layer, and a vertically aligned nanostructure coupled to the cantilever body.

  19. Alignment mechanisms of paramagnetic grains revisited

    NASA Technical Reports Server (NTRS)

    Seki, Munezo

    1989-01-01

    Taking into account the tight coupling of grain axis with angular momentum due to effective dissipation of rotation energy, the alignment of spheroidal grains was investigated by paramagnetic relaxation. Alignment degree will be significantly improved in diffuse clouds. The inclusions of superparamagnetic (SPM) substances may play a key role in grain alignment in dark clouds as well as in diffuse clouds.

  20. Ultrafast electron diffraction from aligned molecules

    SciTech Connect

    Centurion, Martin

    2015-08-17

    The aim of this project was to record time-resolved electron diffraction patterns of aligned molecules and to reconstruct the 3D molecular structure. The molecules are aligned non-adiabatically using a femtosecond laser pulse. A femtosecond electron pulse then records a diffraction pattern while the molecules are aligned. The diffraction patterns are then be processed to obtain the molecular structure.

  1. Alignment of Short Reads: A Crucial Step for Application of Next-Generation Sequencing Data in Precision Medicine

    PubMed Central

    Ye, Hao; Meehan, Joe; Tong, Weida; Hong, Huixiao

    2015-01-01

    Precision medicine or personalized medicine has been proposed as a modernized and promising medical strategy. Genetic variants of patients are the key information for implementation of precision medicine. Next-generation sequencing (NGS) is an emerging technology for deciphering genetic variants. Alignment of raw reads to a reference genome is one of the key steps in NGS data analysis. Many algorithms have been developed for alignment of short read sequences since 2008. Users have to make a decision on which alignment algorithm to use in their studies. Selection of the right alignment algorithm determines not only the alignment algorithm but also the set of suitable parameters to be used by the algorithm. Understanding these algorithms helps in selecting the appropriate alignment algorithm for different applications in precision medicine. Here, we review current available algorithms and their major strategies such as seed-and-extend and q-gram filter. We also discuss the challenges in current alignment algorithms, including alignment in multiple repeated regions, long reads alignment and alignment facilitated with known genetic variants. PMID:26610555

  2. Encouraging Spontaneous Synchronisation with D-Jogger, an Adaptive Music Player That Aligns Movement and Music

    PubMed Central

    Moens, Bart; Muller, Chris; van Noorden, Leon; Franěk, Marek; Celie, Bert; Boone, Jan; Bourgois, Jan; Leman, Marc

    2014-01-01

    In this study we explore how music can entrain human walkers to synchronise to the musical beat without being instructed to do so. For this, we use an interactive music player, called D-Jogger, that senses the user's walking tempo and phase. D-Jogger aligns the music by manipulating the timing difference between beats and footfalls. Experiments are reported that led to the development and optimisation of four alignment strategies. The first strategy matched the music's tempo continuously to the runner's pace. The second strategy matched the music's tempo at the beginning of a song to the runner's pace, keeping the tempo constant for the remainder of the song. The third alignment starts a song in perfect phase synchrony and continues to adjust the tempo to match the runner's pace. The fourth and last strategy additionally adjusts the phase of the music so each beat matches a footfall. The first two strategies resulted in a minor increase of steps in phase synchrony with the main beat when compared to a random playlist, the last two strategies resulted in a strong increase in synchronised steps. These results may be explained in terms of phase-error correction mechanisms and motor prediction schemes. Finding the phase-lock is difficult due to fluctuations in the interaction, whereas strategies that automatically align the phase between movement and music solve the problem of finding the phase-locking. Moreover, the data show that once the phase-lock is found, alignment can be easily maintained, suggesting that less entrainment effort is needed to keep the phase-lock, than to find the phase-lock. The different alignment strategies of D-Jogger can be applied in different domains such as sports, physical rehabilitation and assistive technologies for movement performance. PMID:25489742

  3. Encouraging spontaneous synchronisation with D-Jogger, an adaptive music player that aligns movement and music.

    PubMed

    Moens, Bart; Muller, Chris; van Noorden, Leon; Fran?k, Marek; Celie, Bert; Boone, Jan; Bourgois, Jan; Leman, Marc

    2014-01-01

    In this study we explore how music can entrain human walkers to synchronise to the musical beat without being instructed to do so. For this, we use an interactive music player, called D-Jogger, that senses the user's walking tempo and phase. D-Jogger aligns the music by manipulating the timing difference between beats and footfalls. Experiments are reported that led to the development and optimisation of four alignment strategies. The first strategy matched the music's tempo continuously to the runner's pace. The second strategy matched the music's tempo at the beginning of a song to the runner's pace, keeping the tempo constant for the remainder of the song. The third alignment starts a song in perfect phase synchrony and continues to adjust the tempo to match the runner's pace. The fourth and last strategy additionally adjusts the phase of the music so each beat matches a footfall. The first two strategies resulted in a minor increase of steps in phase synchrony with the main beat when compared to a random playlist, the last two strategies resulted in a strong increase in synchronised steps. These results may be explained in terms of phase-error correction mechanisms and motor prediction schemes. Finding the phase-lock is difficult due to fluctuations in the interaction, whereas strategies that automatically align the phase between movement and music solve the problem of finding the phase-locking. Moreover, the data show that once the phase-lock is found, alignment can be easily maintained, suggesting that less entrainment effort is needed to keep the phase-lock, than to find the phase-lock. The different alignment strategies of D-Jogger can be applied in different domains such as sports, physical rehabilitation and assistive technologies for movement performance. PMID:25489742

  4. Accelerator and transport line survey and alignment

    SciTech Connect

    Ruland, R.E.

    1991-10-01

    This paper summarizes the survey and alignment processes of accelerators and transport lines and discusses the propagation of errors associated with these processes. The major geodetic principles governing the survey and alignment measurement space are introduced and their relationship to a lattice coordinate system shown. The paper continues with a broad overview about the activities involved in the step sequence from initial absolute alignment to final smoothing. Emphasis is given to the relative alignment of components, in particular to the importance of incorporating methods to remove residual systematic effects in surveying and alignment operations. Various approaches to smoothing used at major laboratories are discussed. 47 refs., 19 figs., 1 tab.

  5. Alignment method for solar collector arrays

    DOEpatents

    Driver, Jr., Richard B

    2012-10-23

    The present invention is directed to an improved method for establishing camera fixture location for aligning mirrors on a solar collector array (SCA) comprising multiple mirror modules. The method aligns the mirrors on a module by comparing the location of the receiver image in photographs with the predicted theoretical receiver image location. To accurately align an entire SCA, a common reference is used for all of the individual module images within the SCA. The improved method can use relative pixel location information in digital photographs along with alignment fixture inclinometer data to calculate relative locations of the fixture between modules. The absolute locations are determined by minimizing alignment asymmetry for the SCA. The method inherently aligns all of the mirrors in an SCA to the receiver, even with receiver position and module-to-module alignment errors.

  6. Combining Multiple Pairwise Structure-based Alignments

    Energy Science and Technology Software Center (ESTSC)

    2014-11-12

    CombAlign is a new Python code that generates a gapped, one-to-many, multiple structure-based sequence alignment(MSSA) given a set of pairwise structure-based alignments. In order to better define regions of similarity among related protein structures, it is useful to detect the residue-residue correspondences among a set of pairwise structure alignments. Few codes exist for constructing a one-to-many, multiple sequence alignment derived from a set of structure alignments, and we perceived a need for creating a newmore »tool for combing pairwise structure alignments that would allow for insertion of gaps in the reference structure.« less

  7. FOGSAA: Fast Optimal Global Sequence Alignment Algorithm

    NASA Astrophysics Data System (ADS)

    Chakraborty, Angana; Bandyopadhyay, Sanghamitra

    2013-04-01

    In this article we propose a Fast Optimal Global Sequence Alignment Algorithm, FOGSAA, which aligns a pair of nucleotide/protein sequences faster than any optimal global alignment method including the widely used Needleman-Wunsch (NW) algorithm. FOGSAA is applicable for all types of sequences, with any scoring scheme, and with or without affine gap penalty. Compared to NW, FOGSAA achieves a time gain of (70-90)% for highly similar nucleotide sequences (> 80% similarity), and (54-70)% for sequences having (30-80)% similarity. For other sequences, it terminates with an approximate score. For protein sequences, the average time gain is between (25-40)%. Compared to three heuristic global alignment methods, the quality of alignment is improved by about 23%-53%. FOGSAA is, in general, suitable for aligning any two sequences defined over a finite alphabet set, where the quality of the global alignment is of supreme importance.

  8. Antares beam-alignment-system performance

    SciTech Connect

    Appert, Q.D.; Bender, S.C.

    1983-01-01

    The beam alignment system for the 24-beam-sector Antares CO/sub 2/ fusion laser automatically aligns more than 200 optical elements. A visible-wavelength alignment technique is employed which uses a telescope/TV system to view point-light sources appropriately located down the beamline. The centroids of the light spots are determined by a video tracker, which generates error signals used by the computer control system to move appropriate mirrors in a closed-loop system. Final touch-up alignment is accomplished by projecting a CO/sub 2/ alignment laser beam through the system and sensing its position at the target location. The techniques and control algorithms employed have resulted in alignment accuracies exceeding design requirements. By employing video processing to determine the centroids of diffraction images and by averaging over multiple TV frames, we achieve alignment accuracies better than 0.1 times system diffraction limits in the presence of air turbulence.

  9. Ridge effect and alignment phenomenon

    SciTech Connect

    Lokhtin, I. P. Managadze, A. K. Snigirev, A. M.

    2013-05-15

    It is assumed that the ridge effect observed by the CMS Collaboration in proton-proton collisions at the LHC and the phenomenon observed by the Pamir Collaboration in emulsion experiments with cosmic rays and characterized by the alignment of spots on a film is a manifestation of the same as-yet-unknown mechanism of the emergence of a coplanar structure of events. A large coplanar effect at the LHC in the region of forward rapidities is predicted on the basis of this hypothesis and an analysis of experimental data.

  10. Aligned interactions in cosmic rays

    NASA Astrophysics Data System (ADS)

    Kempa, J.

    2015-12-01

    The first clean Centauro was found in cosmic rays years many ago at Mt Chacaltaya experiment. Since that time, many people have tried to find this type of interaction, both in cosmic rays and at accelerators. But no one has found a clean cases of this type of interaction.It happened finally in the last exposure of emulsion at Mt Chacaltaya where the second clean Centauro has been found. The experimental data for both the Centauros and STRANA will be presented and discussed in this paper. We also present our comments to the intriguing question of the existence of a type of nuclear interactions at high energy with alignment.

  11. MEANS FOR DETERMINING CENTRIFUGE ALIGNMENT

    DOEpatents

    Smith, W.Q.

    1958-08-26

    An apparatus is presented for remotely determining the alignment of a centrifuge. The centrifage shaft is provided with a shoulder, upon which two followers ride, one for detecting radial movements, and one upon the shoulder face for determining the axial motion. The followers are attached to separate liquid filled bellows, and a tube connects each bellows to its respective indicating gage at a remote location. Vibrations produced by misalignment of the centrifuge shaft are transmitted to the bellows, and tbence through the tubing to the indicator gage. This apparatus is particularly useful for operation in a hot cell where the materials handled are dangerous to the operating personnel.

  12. Method for protein structure alignment

    DOEpatents

    Blankenbecler, Richard; Ohlsson, Mattias; Peterson, Carsten; Ringner, Markus

    2005-02-22

    This invention provides a method for protein structure alignment. More particularly, the present invention provides a method for identification, classification and prediction of protein structures. The present invention involves two key ingredients. First, an energy or cost function formulation of the problem simultaneously in terms of binary (Potts) assignment variables and real-valued atomic coordinates. Second, a minimization of the energy or cost function by an iterative method, where in each iteration (1) a mean field method is employed for the assignment variables and (2) exact rotation and/or translation of atomic coordinates is performed, weighted with the corresponding assignment variables.

  13. MACSE: Multiple Alignment of Coding SEquences Accounting for Frameshifts and Stop Codons

    PubMed Central

    Ranwez, Vincent; Harispe, Sébastien; Delsuc, Frédéric; Douzery, Emmanuel J. P.

    2011-01-01

    Until now the most efficient solution to align nucleotide sequences containing open reading frames was to use indirect procedures that align amino acid translation before reporting the inferred gap positions at the codon level. There are two important pitfalls with this approach. Firstly, any premature stop codon impedes using such a strategy. Secondly, each sequence is translated with the same reading frame from beginning to end, so that the presence of a single additional nucleotide leads to both aberrant translation and alignment. We present an algorithm that has the same space and time complexity as the classical Needleman-Wunsch algorithm while accommodating sequencing errors and other biological deviations from the coding frame. The resulting pairwise coding sequence alignment method was extended to a multiple sequence alignment (MSA) algorithm implemented in a program called MACSE (Multiple Alignment of Coding SEquences accounting for frameshifts and stop codons). MACSE is the first automatic solution to align protein-coding gene datasets containing non-functional sequences (pseudogenes) without disrupting the underlying codon structure. It has also proved useful in detecting undocumented frameshifts in public database sequences and in aligning next-generation sequencing reads/contigs against a reference coding sequence. MACSE is distributed as an open-source java file executable with freely available source code and can be used via a web interface at: http://mbb.univ-montp2.fr/macse. PMID:21949676

  14. Air Quality Management Using Modern Remote Sensing and Spatial Technologies and Associated Societal Costs

    PubMed Central

    Uddin, Waheed

    2006-01-01

    This paper presents a study of societal costs related to public health due to the degradation of air quality and the lack of physical activity, both affected by our built environment. The paper further shows road safety as another public health concern. Traffic fatalities are the number one cause of death in the world. Traffic accidents result in huge financial loss to the people involved and the related public health cost is a significant part of the total societal cost. Motor vehicle exhausts and industrial emissions, gasoline vapors, and chemical solvents as well as natural sources emit nitrogen oxides and volatile organic compounds, which are precursors to the formation of ground-level Ozone. High concentration values of ground-level Ozone in hot summer days produce smog and lead to respiratory problems and loss in worker’s productivity. These factors and associated economic costs to society are important in establishing public policy and decision-making for sustainable transportation and development of communities in both industrialized and developing countries. This paper presents new science models for predicting ground-level Ozone and related air quality degradation. The models include predictor variables of daily climatological data, traffic volume and mix, speed, aviation data, and emission inventory of point sources. These models have been implemented in the user friendly AQMAN computer program and used for a case study in Northern Mississippi. Life-cycle benefits from reduced societal costs can be used to implement sustainable transportation policies, enhance investment decision-making, and protect public health and the environment. PMID:16968969

  15. Hydrogen Vehicles: Impacts of DOE Technical Targets on Market Acceptance and Societal Benefits

    SciTech Connect

    Lin, Zhenhong; Dong, Jing; Greene, David L

    2013-01-01

    Hydrogen vehicles (H2V), including H2 internal combustion engine, fuel cell and fuel cell plugin hybrid, could greatly reduce petroleum consumption and greenhouse gas (GHG) emissions in the transportation sector. The U.S. Department of Energy has adopted targets for vehicle component technologies to address key technical barriers towidespread commercialization of H2Vs. This study estimates the market acceptance of H2Vs and the resulting societal benefits and subsidy in 41 scenarios that reflect a wide range of progress in meeting these technical targets. Important results include: (1) H2Vs could reach 20e70% market shares by 2050, depending on progress in achieving the technical targets.With a basic hydrogen infrastructure (w5% hydrogen availability), the H2V market share is estimated to be 2e8%. Fuel cell and hydrogen costs are the most important factors affecting the long-term market shares of H2Vs. (2) Meeting all technical targets on time could result in about an 80% cut in petroleumuse and a 62% (or 72% with aggressive electricity de-carbonization) reduction in GHG in 2050. (3) The required hydrogen infrastructure subsidy is estimated to range from $22 to $47 billion and the vehicle subsidy from $4 to $17 billion. (4) Long-term H2V market shares, societal benefits and hydrogen subsidies appear to be highly robust against delay in one target, if all other targets are met on time. R&D diversification could provide insurance for greater societal benefits. (5) Both H2Vs and plug-in electric vehicles could exceed 50% market shares by 2050, if all targets are met on time. The overlapping technology, the fuel cell plug-in hybrid electric vehicle, appears attractive both in the short and long runs, but for different reasons.

  16. Velocity-aligned Doppler spectroscopy

    SciTech Connect

    Xu, Z.; Koplitz, B.; Wittig, C.

    1989-03-01

    The technique of velocity-aligned Doppler spectrosocopy (VADS) is presented and discussed. For photolysis/probe experiments with pulsed initiation, VADS can yield Doppler profiles for nascent photofragments that allow detailed center-of-mass (c.m.) kinetic energy distributions to be extracted. When compared with traditional forms of Doppler spectroscopy, the improvement in kinetic energy resolution is dramatic. Changes in the measured profiles are a consequence of spatial discrimination (i.e., focused and overlapping photolysis and probe beams) and delayed observation. These factors result in the selective detection of species whose velocities are aligned with the wave vector of the probe radiation k/sub pr/, thus revealing the speed distribution along k/sub pr/ rather than the distribution of nascent velocity components projected upon this direction. Mathematical details of the procedure used to model VADS are given, and experimental illustrations for HI, H/sub 2/S, and NH/sub 3/ photodissociation are presented. In these examples, pulsed photodissociation produces H atoms that are detected by sequential two-photon, two-frequency ionization via Lyman-..cap alpha.. with a pulsed laser (121.6+364.7 nm), and measuring the Lyman-..cap alpha.. Doppler profile as a function of probe delay reveals both internal and c.m. kinetic energy distributions for the photofragments. Strengths and weaknesses of VADS as a tool for investigating photofragmentation phenomena are also discussed.

  17. Measuring alignment of loading fixture

    DOEpatents

    Scavone, Donald W.

    1989-01-01

    An apparatus and method for measuring the alignment of a clevis and pin type loading fixture for compact tension specimens include a pair of substantially identical flat loading ligaments. Each loading ligament has two apertures for the reception of a respective pin of the loading fixture and a thickness less than one-half of a width of the clevis opening. The pair of loading ligaments are mounted in the clevis openings at respective sides thereof. The loading ligaments are then loaded by the pins of the loading fixture and the strain in each loading ligament is measured. By comparing the relative strain of each loading ligament, the alignment of the loading fixture is determined. Preferably, a suitable strain gage device is located at each longitudinal edge of a respective loading ligament equidistant from the two apertures in order to determine the strain thereat and hence the strain of each ligament. The loading ligaments are made substantially identical by jig grinding the loading ligaments as a matched set. Each loading ligament can also be individually calibrated prior to the measurement.

  18. Generating alignments of genetic sequences

    SciTech Connect

    Butler, R.; Butler, T.; Foster, I.; Karonis, N.; Olson, R.; Overbeek, R.; Pfluger, N.; Price, M.; Tuecke, S.

    1989-06-01

    Molecular biologists have recently developed the technology required to determine the genetic information of complete organisms. They are now faced with a number of interesting computational problems as they attempt to process data. We are interested in developing a software environment to support molecular biologists. As their computational problems are frequently complex and computation-intensive, we believe that such an environment must both support rapid prototyping of new algorithms and allow high performance execution on a variety of multiprocessor configurations. We believe that this can be achieved using a bilingual approach, in which the upper levels of programs are coded in a concurrent logic programming language and the lower levels in C. The concurrent language provides ease of parallel programming and portability over a range of parallel computers; C provides efficient implementation of low-level algorithms. To explore the suitability of this approach, we have investigated its use in attacking a prototypical computational problem, the problem of aligning a set of sequences of genetic material. This report introduces the algorithm used to generate alignments, outlines the techniques used to develop the bilingual program, and describes initial experiments in parallel execution of this program. 7 refs., 2 tabs.

  19. The chief strategy officer.

    PubMed

    Breene, R Timothy S; Nunes, Paul F; Shill, Walter E

    2007-10-01

    They're nominally and ultimately responsible for strategy, but today's CEOs have less and less time to devote to it. As a result, CEOs are appointing "chief strategy officers"--executives specifically tasked with creating, communicating, executing, and sustaining a company's strategic initiatives. In this article, three authors from Accenture share the results of their research on this emerging organizational role. The typical CSO or top strategy executive is not a pure strategist, conducting long-range planning in relative isolation. Most CSOs consider themselves doers first, with the mandate, credentials, and desire to act as well as advise. They are seasoned executives with a strong strategy orientation who have usually worn many operations hats before taking on the role. Strategy executives are charged with three critical jobs that together form the very definition of strategy execution. First, they must clarify the company's strategy for themselves and for every business unit and function, ensuring that all employees understand the details of the strategic plan and how their work connects to corporate goals. Second, CSOs must drive immediate change. The focus of the job almost always quickly evolves from creating shared alignment around a vision to riding herd on the ensuing change effort. Finally, a CSO must drive decision making that sustains organizational change. He or she must be that person who, in the CEO's stead, can walk into any office and test whether the decisions being made are aligned with the strategy and are creating the desired results. When decisions below the executive suite aren't being made in accordance with strategy, much of the CSO's job involves learning why and quickly determining whether to stay the course or change tack. PMID:17972497

  20. Societal and ethical implications of anti-spoofing technologies in biometrics.

    PubMed

    Rebera, Andrew P; Bonfanti, Matteo E; Venier, Silvia

    2014-03-01

    Biometric identification is thought to be less vulnerable to fraud and forgery than are traditional forms of identification. However biometric identification is not without vulnerabilities. In a 'spoofing attack' an artificial replica of an individual's biometric trait is used to induce a system to falsely infer that individual's presence. Techniques such as liveness-detection and multi-modality, as well as the development of new and emerging modalities, are intended to secure biometric identification systems against such threats. Unlike biometrics in general, the societal and ethical issues raised by spoofing and anti-spoofing techniques have not received much attention. This paper examines these issues. PMID:23579470

  1. Meeting the societal need for new antibiotics: the challenges for the pharmaceutical industry

    PubMed Central

    O'Brien, Seamus

    2015-01-01

    The rise of antibiotic resistance is leading to clinicians being increasingly faced with clinical failure due to the lack of effective and safe treatment options. New antibiotics are needed now for current multi-drug resistant infections but also in preparation for emerging and anticipated threats. There are significant challenges for the pharmaceutical industry to discover and develop new antibiotics including a business model that balances reasonable reimbursement with appropriate use. This summary reviews the key challenges and collaborative interventions that may contribute to addressing a societal problem. PMID:25601037

  2. Alcohol-Related Antigay Aggression: Theoretical Considerations for Individual-and Societal-Level Interventions

    PubMed Central

    Parrott, Dominic J.; Miller, Cameron A.

    2008-01-01

    A substantial literature has identified risk factors for intoxicated aggression and the mechanisms by which these effects are exerted. This theoretical and empirical foundation is a valuable resource for the development of treatment inventions. In contrast, a comparable literature is not available to guide development of clinical interventions for intoxicated antigay aggression. To address this gap in the literature, the present article 1) identifies risk factors and mechanisms pertinent to alcohol-related antigay aggression, 2) advances predictions regarding how alcohol will increase antigay aggression, and 3) reviews societal- and individual-level considerations for intervention based upon these hypotheses. PMID:19938923

  3. Being who I am: effective teaching, learning, student support, and societal change through LGBQ faculty freedom.

    PubMed

    Orlov, Janice M; Allen, Katherine R

    2014-01-01

    Framed within the context of a heterosexist society in which not all sexual minority faculty feel professionally and/or personally safe stepping out of the classroom closet, this qualitative study examines the phenomenon of non-heterosexual faculty disclosing their sexual orientation to students in their classrooms. Findings demonstrate the depth and magnitude of impact the disclosure has on teaching, learning, student support, and societal change. Overarching is that faculty do not necessarily view the experience as "coming out in the classroom," but rather as "being who I am" in terms of freedom to present an authentic self, if so desired, to students. PMID:24325330

  4. Alignment of the ATLAS inner detector

    NASA Astrophysics Data System (ADS)

    Wang, Jike; ATLAS Collaboration

    2012-06-01

    In order to reach the track parameter accuracy motivated by the physics goals of the experiment, the ATLAS tracking system needs to determine accurately its almost 700,000 degrees of freedom. The demanded precision for the alignment of the silicon sensors is below 10 ?m. The implementation of the track based alignment within the ATLAS software framework unifies different alignment approaches and allows the alignment of all tracking subsystems together. The alignment software relies on the tracking information (track-hit residuals) but also includes the capability to set constraints on the beam-spot and primary vertex as well as the momentum measured by the Muon System or the E/p using the calorimetry information. The alignment chain starts at the trigger level where a stream of high pT isolated tracks is selected online. Also a cosmic ray trigger is enabled while ATLAS is recording collision data, thus a stream of cosmic-ray tracks is recorded exactly with the same detector operating conditions as the normal collision tracks. We will present results of the alignment of the ATLAS tracker using the 2011 collision data. The validation of the alignment is performed using track-hit residuals as well as using more advanced physics observables. The results of the alignment with real data reveals that the attained precision for the alignment parameters is approximately 5 ?m.

  5. Quantifying cellular alignment on anisotropic biomaterial platforms

    PubMed Central

    Nectow, Alexander R.; Kilmer, Misha E.; Kaplan, David L.

    2014-01-01

    How do we quantify cellular alignment? Cellular alignment is an important technique used to study and promote tissue regeneration in vitro and in vivo. Indeed, regenerative outcomes are often strongly correlated with the efficacy of alignment, making quantitative, automated assessment an important goal for the field of tissue engineering. There currently exist various classes of algorithms, which effectively address the problem of quantifying individual cellular alignments using Fourier methods, kernel methods, and elliptical approximation; however, these algorithms often yield population distributions and are limited by their inability to yield a scalar metric quantifying the efficacy of alignment. The current work builds on these classes of algorithms by adapting the signal processing methods previously used by our group to study the alignment of cellular processes. We use an automated, ellipse-fitting algorithm to approximate cell body alignment with respect to a silk biomaterial scaffold, followed by the application of the normalized cumulative periodogram criterion to produce a scalar value quantifying alignment. The proposed work offers a generalized method for assessing cellular alignment in complex, two-dimensional environments. This method may also offer a novel alternative for assessing the alignment of cell types with polarity, such as fibroblasts, endothelial cells, and mesenchymal stem cells, as well as nuclei. PMID:23520051

  6. Modified alignment CGHs for aspheric surface test

    NASA Astrophysics Data System (ADS)

    Song, Jae-Bong; Yang, Ho-Soon; Rhee, Hyug-Gyo; Lee, Yun-Woo

    2009-08-01

    Computer Generated Holograms (CGH) for optical test are commonly consisted of one main pattern for testing aspheric surface and some alignment patterns for aligning the interferometer, CGH, and the test optics. To align the CGH plate and the test optics, we designed the alignment CGHs modified from the cat's eye alignment method, which are consisted of a couple of CGH patterns. The incident beam passed through the one part of the alignment CGH pattern is focused onto the one radius position of the test aspheric surface, and is reflected to the other part, and vice versa. This method has several merits compared to the conventional cat's eye alignment method. First, this method can be used in testing optics with a center hole, and the center part of CGH plate can be assigned to the alignment pattern. Second, the alignment pattern becomes a concentric circular arc pattern. The whole CGH patterns including the main pattern and alignment patterns are consisted of only concentric circular fringes. This concentric circular pattern can be easily made by the polar coordinated writer with circular scanning. The required diffraction angle becomes relatively small, so the 1st order diffraction beams instead of the 3rd order diffraction beam can be used as alignment beams, and the visibility can be improved. This alignment method also is more sensitive to the tilt and the lateral shift of the test aspheric surface. Using this alignment pattern, a 200 mm diameter F/0.5 aspheric mirror and a 600 mm diameter F/0.9 mirror were tested.

  7. CYLINDER LENS ALIGNMENT IN THE LTP

    SciTech Connect

    TAKACS, P.Z.

    2005-07-26

    The Long Trace Profiler (LTP), is well-suited for the measurement of the axial figure of cylindrical mirrors that usually have a long radius of curvature in the axial direction but have a short radius of curvature in the sagittal direction. The sagittal curvature causes the probe beam to diverge in the transverse direction without coming to a focus on the detector, resulting in a very weak signal. It is useful to place a cylinder lens into the optical system above the mirror under test to refocus the sagittal divergence and increase the signal level. A positive cylinder lens can be placed at two positions above the surface: the Cat's Eye reflection position and the Wavefront-Matching position. The Cat's Eye position, is very tolerant to mirror misalignment, which is not good if absolute axial radius of curvature is to be measured. Lateral positioning and rotational misalignments of lens and the mirror combine to produce unusual profile results. This paper looks at various alignment issues with measurements and by raytrace simulations to determine the best strategy to minimize radius of curvature errors in the measurement of cylindrical aspheres.

  8. SAGA: sequence alignment by genetic algorithm.

    PubMed Central

    Notredame, C; Higgins, D G

    1996-01-01

    We describe a new approach to multiple sequence alignment using genetic algorithms and an associated software package called SAGA. The method involves evolving a population of alignments in a quasi evolutionary manner and gradually improving the fitness of the population as measured by an objective function which measures multiple alignment quality. SAGA uses an automatic scheduling scheme to control the usage of 22 different operators for combining alignments or mutating them between generations. When used to optimise the well known sums of pairs objective function, SAGA performs better than some of the widely used alternative packages. This is seen with respect to the ability to achieve an optimal solution and with regard to the accuracy of alignment by comparison with reference alignments based on sequences of known tertiary structure. The general attraction of the approach is the ability to optimise any objective function that one can invent. PMID:8628686

  9. Automated interferometric alignment system for paraboloidal mirrors

    DOEpatents

    Maxey, L.C.

    1993-09-28

    A method is described for a systematic method of interpreting interference fringes obtained by using a corner cube retroreflector as an alignment aid when aligning a paraboloid to a spherical wavefront. This is applicable to any general case where such alignment is required, but is specifically applicable in the case of aligning an autocollimating test using a diverging beam wavefront. In addition, the method provides information which can be systematically interpreted such that independent information about pitch, yaw and focus errors can be obtained. Thus, the system lends itself readily to automation. Finally, although the method is developed specifically for paraboloids, it can be seen to be applicable to a variety of other aspheric optics when applied in combination with a wavefront corrector that produces a wavefront which, when reflected from the correctly aligned aspheric surface will produce a collimated wavefront like that obtained from the paraboloid when it is correctly aligned to a spherical wavefront. 14 figures.

  10. Laminar silk scaffolds for aligned tissue fabrication

    PubMed Central

    Mandal, Biman B.; Gil, Eun Seok; Panilaitis, Bruce; Kaplan, David L.

    2013-01-01

    3D biomaterial scaffolds with aligned architecture are of vital importance in tissue regeneration to mimic native tissue hierarchy and hence function. We demonstrate a generic method to produce aligned biomaterial scaffolds using the physics of directional ice freezing. Homogeneously aligned 3D silk scaffold with high porosity and alignment was demonstrated. The method can be adapted to a wide range of polymers and is devoid of any chemical reactions, thus avoiding potential complications associated with by-products and purification procedures. Subsequently, the 3D aligned system was tested for mechanical properties and cellular responses with chondrocytes and bone marrow derived human mesenchymal stem cells, assessing survival, proliferation and differentiation. In vivo tests suggested biocompatibility of the matrices for future tissue engineering applications, specifically in areas where high cellular alignment is needed. PMID:23161731

  11. Aligning Business Motivations in a Services Computing Design

    NASA Astrophysics Data System (ADS)

    Roach, T.; Low, G.; D'Ambra, J.

    The difficulty in aligning business strategies with the design of enterprise systems has been recognised as a major inhibitor of successful IT initiatives. Service-oriented architecture (SOA) initiatives imply an entirely new approach to enterprise process enablement and require significant architectural redesign. Successful SOA deployments are highly dependent on the degree to which flexible support for evolving business strategies is embedded into their designs. This chapter addresses the challenge of modelling business strategies in support of SOA designs. The proposed framework is derived from conceptual elements introduced in the OMG business motivation model and delivers an architectural view for business stakeholders in a computational-independent model (CIM). This model represents the first of three layers that will define a complete reference architecture for a service-based computing model.

  12. The Upper San Pedro Partnership: A Case Study of Successful Strategies to Connect Science to Societal Needs

    NASA Astrophysics Data System (ADS)

    Goodrich, D. C.; Richter, H.; Varady, R.; Browning-Aiken, A.; Shuttleworth, J.

    2006-12-01

    The Upper San Pedro Partnership (USPP) (http://www.usppartnership.com/) has been in existence since 1998. Its purpose is to coordinate and cooperate in the implementation of comprehensive policies and projects to meet the long-term water needs of residents within the U.S. side of the basin and of the San Pedro Riparian National Conservation Area. The Partnership consists of 21 local, state, and Federal agencies, NGO's and a private water company. In 2004 it was recognized by Congress in Section 321 of Public Law 108-136 and required to make annual reports to Congress on its progress in bringing the basin water budget into balance by 2011. The Partnership is dedicated to science-based decision making. This presentation will provide an overview of the evolution of natural resources research in the binational (U.S.-Mexico) San Pedro Basin into a mature example of integrated science and decision making embodied in the USPP. It will discuss the transition through science and research for understanding; to science for addressing a need; to integrated policy development and science. At each stage the research conducted becomes more interdisciplinary, first across abiotic disciplines (hydrology, remote sensing, atmospheric science), then a merging of abiotic and biotic disciplines (adding ecology and plant physiology), and finally a further merging with the social sciences and policy and decision making for resource management. Federal, university, and NSF SAHRA Science and Technology Center research has been planned and conducted directly with the USPP. Because of the success the San Pedro has been designated as an operational HELP (Hydrology for the Environment, Life, and Policy) demonstration basin—the most advanced category. Lessons learned from this experience will be reviewed with the intent providing guidance to ensure that hydrologic and watershed research is socially and scientifically relevant and will directly address the needs of policy makers and resource managers. Additionally, the successful examples of science-society linkages can provide helpful models for basins, especially transnational basins, elsewhere.

  13. The San Pedro Basin: A Case Study of US and Mexican Strategies to Connect Science to Societal Needs 1917

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The San Pedro River originates in northern Sonora near the town of Cananea and spans the U.S. – Mexico border into southeastern Arizona. The San Pedro Basin and perennial portions of its river support one of the most ecological diverse regions in the world. The regional groundwater aquifer which l...

  14. Optoelectronic Alignment And Ultrasonic Ranging Apparatus

    NASA Technical Reports Server (NTRS)

    Collins, J. David; Rivera, Jorge; Youngquist, Robert; Moerk, J. Steven; Haskell, William; Cox, Robert; Rose, Kenneth

    1995-01-01

    Beam of light guides alignment, then range measured by use of ultrasound. Optoelectronic/ultrasonic apparatus facilitates three-dimensional alignment of spot on one object with respect to facing (but not touching) spot on another nearby object. Designed to help in positioning external tank of space shuttle between two solid rocket boosters. Useful in other applications to align large components to be locked together in assemblies.

  15. Role of liability preferences in societal technology choices: results of a pilot study

    SciTech Connect

    Cantor, R.; Rayner, S.; Braid, B.

    1985-01-01

    At the 1984 Annual Meeting of the Society for Risk Analysis, Steve Rayner presented a paper that challenged the conventional wisdom of risk management research. In that paper, he argued that resolving the question, ''How safe is safe enough.'' is less important in making societal technology choices than ''How fair is safe enough.'' Adopting the fairness question as the concern of risk management would imply that the process of technology choice explicitly recognize the preferred principles different parties hold with respect to obtaining consent from those affected by the risks, distributing the liabilities, and justifying trust in the relevant institutions. This paper discusses a recent empirical pilot study which explored the fairness hypothesis in the context of nuclear power. Individual interviews and focus groups were conducted to examine whether or not preferred principles for liability distributions were consistent with those suggested by the cultural characteristics of the constituency. The results suggest that for this type of societal technology choice, violation of these preferred principles may be a major source of the conflict between different constituencies. Additionally, the study contributes towards the development of a new approach in risk management that combines the cultural model of risk perceptions with the decision-theoretic approaches found in economics and psychology.

  16. Optimizing Societal Benefit using a Systems Engineering Approach for Implementation of the GEOSS Space Segment

    NASA Technical Reports Server (NTRS)

    Killough, Brian D., Jr.; Sandford, Stephen P.; Cecil, L DeWayne; Stover, Shelley; Keith, Kim

    2008-01-01

    The Group on Earth Observations (GEO) is driving a paradigm shift in the Earth Observation community, refocusing Earth observing systems on GEO Societal Benefit Areas (SBA). Over the short history of space-based Earth observing systems most decisions have been made based on improving our scientific understanding of the Earth with the implicit assumption that this would serve society well in the long run. The space agencies responsible for developing the satellites used for global Earth observations are typically science driven. The innovation of GEO is the call for investments by space agencies to be driven by global societal needs. This paper presents the preliminary findings of an analysis focused on the observational requirements of the GEO Energy SBA. The analysis was performed by the Committee on Earth Observation Satellites (CEOS) Systems Engineering Office (SEO) which is responsible for facilitating the development of implementation plans that have the maximum potential for success while optimizing the benefit to society. The analysis utilizes a new taxonomy for organizing requirements, assesses the current gaps in spacebased measurements and missions, assesses the impact of the current and planned space-based missions, and presents a set of recommendations.

  17. Alternative futures for societal change: The Shared Socio-Economic Pathways (SSPs) (Invited)

    NASA Astrophysics Data System (ADS)

    O'Neill, B. C.

    2013-12-01

    Deciding how best to respond to the challenge of climate change requires anticipating not only how climate might change in the future, but how society might change as well. Changes in population and economic growth, innovation, technological development, governance, culture, and lifestyle all will affect the energy use and land use that drive climate change, as well as society's capacity to reduce emissions or adapt to climate change impacts. Developing a set of alternative scenarios for societal development is one way to capture and explore the uncertainty in future conditions. The climate change research community has produced a new set of five such scenarios, called Shared Socio-Economic Pathways (SSPs), that is intended to underpin scientific studies, assessments, and policy dialogues for the next decade or more. The SSPs include both qualitative narratives and quantitative projections of key elements such as population, economic growth, urbanization, and educational attainment. They are designed to span a wide range of future conditions in terms of the challenges they present to both adaptation and mitigation. The SSPs are one component of a larger scenario framework which also includes a set of radiative forcing pathways and climate model simulations based on them. Alternative climate futures will be integrated with the alternative societal futures represented by the SSPs to investigate climate change impacts as well as mitigation and adaptation response options.

  18. The Alignment of Galaxy Structures

    NASA Astrophysics Data System (ADS)

    Biernacka, M.; Panko, E.; Bajan, K.; Godłowski, W.; Flin, P.

    2015-11-01

    We analyzed the orientation of the sample of ACO galaxy clusters. We examined the alignment in a subsample of 1056 galaxy structures taken from the Panko-Flin (2006) Catalog with known BM morphological types. We were looking for a correlation between the orientation of the cluster and the positions of neighboring clusters. The Binggeli effect (the excess of small values of the Δθ angles between the direction toward neighboring clusters and the cluster position angle) is observed, having a range up to about 45 h-1 Mpc. The strongest effect was found for elongated BM type I clusters. This is probably connected with the origins of the supergiant galaxy and with cluster formation along a long filament or plane in a supercluster.

  19. Tonal alignment in Irish dialects.

    PubMed

    Dalton, Martha; Chasaide, Ailbhe Ní

    2005-01-01

    A comparison of the contour alignment of nuclear and initial prenuclear accents was carried out for the Irish dialects of Gaoth Dobhair in Ulster (GD-U) and Cois Fharraige in Connaught (CF-C). This was done across conditions where the number of unstressed syllables following the nuclear and preceding the initial prenuclear accents was varied from 2-0. This tests a variable peak hypothesis prompted by findings for other languages, that peak timing drifts as a function of the number of syllables preceding (the prenuclear) and following (the nuclear) accent. These data also test a second hypothesis that the L*+H dominant accent of GD-U might be viewed as being underlyingly the same as the dominant H* or H*+L accent of the CF-C dialect. According to this realignment hypothesis, the difference between these Ulster and Connaught dialects lies in the way that the melodic tier is aligned to the segmental tier: GD-U would be viewed as having a delayed realization of the peak relative to the Connaught dialect. Results do not support the variable peak hypothesis for Irish, as in either dialect, the peak appeared to be rather fixed across the three conditions examined (though not necessarily identical for prenuclear and nuclear positions). The results also militate against the realignment hypothesis, which rather than providing a more simple unifying account, would greatly complicate it. One reason is that there is a peak timing difference between the nuclear and prenuclear accents of CF-C, not mirrored in GD-U. Furthermore, even if one were to limit consideration to a single (e.g., prenuclear) context, a simple realignment of the accents in one dialect does not generate the appropriate contour in the other. PMID:16715684

  20. Laser optics accurately measure running shaft alignment

    SciTech Connect

    Bloch, H.P.

    1990-11-05

    This paper discusses how laser-optic alignment systems can be employed effectively to detect and accurately measure rotary machinery shaft alignment while the machinery is running. These measurements can be used to maintain proper alignment at operating conditions. One of the many significant factors influencing machinery reliability in process plants is alignment accuracy. When driven process machines operate in misaligned condition with respect to their drivers, equipment bearings are exposed to additional loads. Vibration severity may increase, bearings will be more highly loaded, and equipment life expectancy will diminish as a result.

  1. DNAAlignEditor: DNA alignment editor tool

    PubMed Central

    Sanchez-Villeda, Hector; Schroeder, Steven; Flint-Garcia, Sherry; Guill, Katherine E; Yamasaki, Masanori; McMullen, Michael D

    2008-01-01

    Background With advances in DNA re-sequencing methods and Next-Generation parallel sequencing approaches, there has been a large increase in genomic efforts to define and analyze the sequence variability present among individuals within a species. For very polymorphic species such as maize, this has lead to a need for intuitive, user-friendly software that aids the biologist, often with naïve programming capability, in tracking, editing, displaying, and exporting multiple individual sequence alignments. To fill this need we have developed a novel DNA alignment editor. Results We have generated a nucleotide sequence alignment editor (DNAAlignEditor) that provides an intuitive, user-friendly interface for manual editing of multiple sequence alignments with functions for input, editing, and output of sequence alignments. The color-coding of nucleotide identity and the display of associated quality score aids in the manual alignment editing process. DNAAlignEditor works as a client/server tool having two main components: a relational database that collects the processed alignments and a user interface connected to database through universal data access connectivity drivers. DNAAlignEditor can be used either as a stand-alone application or as a network application with multiple users concurrently connected. Conclusion We anticipate that this software will be of general interest to biologists and population genetics in editing DNA sequence alignments and analyzing natural sequence variation regardless of species, and will be particularly useful for manual alignment editing of sequences in species with high levels of polymorphism. PMID:18366684

  2. Optimal network alignment with graphlet degree vectors.

    PubMed

    Milenković, Tijana; Ng, Weng Leong; Hayes, Wayne; Przulj, Natasa

    2010-01-01

    Important biological information is encoded in the topology of biological networks. Comparative analyses of biological networks are proving to be valuable, as they can lead to transfer of knowledge between species and give deeper insights into biological function, disease, and evolution. We introduce a new method that uses the Hungarian algorithm to produce optimal global alignment between two networks using any cost function. We design a cost function based solely on network topology and use it in our network alignment. Our method can be applied to any two networks, not just biological ones, since it is based only on network topology. We use our new method to align protein-protein interaction networks of two eukaryotic species and demonstrate that our alignment exposes large and topologically complex regions of network similarity. At the same time, our alignment is biologically valid, since many of the aligned protein pairs perform the same biological function. From the alignment, we predict function of yet unannotated proteins, many of which we validate in the literature. Also, we apply our method to find topological similarities between metabolic networks of different species and build phylogenetic trees based on our network alignment score. The phylogenetic trees obtained in this way bear a striking resemblance to the ones obtained by sequence alignments. Our method detects topologically similar regions in large networks that are statistically significant. It does this independent of protein sequence or any other information external to network topology. PMID:20628593

  3. VIRUS spectrograph assembly and alignment procedures

    NASA Astrophysics Data System (ADS)

    Prochaska, Travis; Allen, Richard D.; Boster, Emily; DePoy, D. L.; Herbig, Benjamin; Hill, Gary J.; Lee, Hanshin; Marshall, Jennifer L.; Martin, Emily C.; Meador, William; Rheault, Jean-Philippe; Tuttle, Sarah E.; Vattiat, Brian L.

    2012-09-01

    We describe the mechanical assembly and optical alignment processes used to construct the Visual Integral-Field Replicable Unit Spectrograph (VIRUS) instrument. VIRUS is a set of 150+ optical spectrographs designed to support observations for the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX). To meet the instrument's manufacturing constraints, a production line will be set up to build subassemblies in parallel. To aid in the instrument's assembly and alignment, specialized fixtures and adjustment apparatuses have been developed. We describe the design and operations of the various optics alignment apparatuses, as well as the mirrors' alignment and bonding fixtures.

  4. Advancements of vertically aligned liquid crystal displays.

    PubMed

    Kumar, Pankaj; Jaggi, Chinky; Sharma, Vandna; Raina, Kuldeep Kumar

    2016-02-01

    This review describes the recent advancements in the field of the vertical aligned (VA) liquid crystal displays. The process and formation of different vertical alignment modes such as conventional VA, patterned VA, multi-domain VA, and polymer stabilised VA etc are widely discussed. Vertical alignment of liquid crystal due to nano particle dispersion in LC host, bifunctional PR-SAM formed by silane coupling reaction to oxide surfaces, azo dye etc., are also highlighted and discussed. Overall, the article highlights the advances in the research of vertical aligned liquid crystal in terms of their scientific and technological aspects. PMID:26800482

  5. Optimal Network Alignment with Graphlet Degree Vectors

    PubMed Central

    Milenkovi?, Tijana; Ng, Weng Leong; Hayes, Wayne; Pržulj, Nataša

    2010-01-01

    Important biological information is encoded in the topology of biological networks. Comparative analyses of biological networks are proving to be valuable, as they can lead to transfer of knowledge between species and give deeper insights into biological function, disease, and evolution. We introduce a new method that uses the Hungarian algorithm to produce optimal global alignment between two networks using any cost function. We design a cost function based solely on network topology and use it in our network alignment. Our method can be applied to any two networks, not just biological ones, since it is based only on network topology. We use our new method to align protein-protein interaction networks of two eukaryotic species and demonstrate that our alignment exposes large and topologically complex regions of network similarity. At the same time, our alignment is biologically valid, since many of the aligned protein pairs perform the same biological function. From the alignment, we predict function of yet unannotated proteins, many of which we validate in the literature. Also, we apply our method to find topological similarities between metabolic networks of different species and build phylogenetic trees based on our network alignment score. The phylogenetic trees obtained in this way bear a striking resemblance to the ones obtained by sequence alignments. Our method detects topologically similar regions in large networks that are statistically significant. It does this independent of protein sequence or any other information external to network topology. PMID:20628593

  6. Anisotropic light emission from aligned luminophores

    NASA Astrophysics Data System (ADS)

    Verbunt, Paul P. C.; de Jong, Ties M.; de Boer, Dick K. G.; Broer, Dirk J.; Debije, Michael G.

    2014-07-01

    The emission of aligned dichroic dyes in a luminescent solar concentrator (LSC) illuminated from one side with collimated light results in a non-isotropic light distribution. We develop a model to describe emission profiles for dichroic dyes aligned at a general tilt angle with respect to a lightguide surface (including planar and homeotropic alignments) for various order parameters. We compare calculations with experimental results, demonstrating the dichroic nature of the dyes can have significant impact on the surface loss of luminescent solar concentrators. Including this dichroic nature is essential in correctly simulating the preferred edge emissions demonstrated experimentally in dyes aligned planarly on the surface of a lightguide.

  7. Liquid crystal alignment in cylindrical microcapillaries

    NASA Astrophysics Data System (ADS)

    Chychłowski, M.; Yaroshchuk, O.; Kravchuk, R.; Woliński, T.

    2012-03-01

    A variety of alignment configurations of liquid crystals (LCs) inside the glassy cylindrical capillaries is realized by using alignment materials providing different anchoring. The radial configuration with central disclination line is obtained for homeotropic boundary conditions. In turn, the axial, transversal and tilted alignment structures are realized by using materials for planar anchoring. The uniformity and controlling of the latter structures were provided by photoalignment method. This approach can be further used to control LC alignment in the photonic crystal fibers recognized as advanced elements for different optical devices.

  8. The twilight zone of cis element alignments.

    PubMed

    Sebastian, Alvaro; Contreras-Moreira, Bruno

    2013-02-01

    Sequence alignment of proteins and nucleic acids is a routine task in bioinformatics. Although the comparison of complete peptides, genes or genomes can be undertaken with a great variety of tools, the alignment of short DNA sequences and motifs entails pitfalls that have not been fully addressed yet. Here we confront the structural superposition of transcription factors with the sequence alignment of their recognized cis elements. Our goals are (i) to test TFcompare (http://floresta.eead.csic.es/tfcompare), a structural alignment method for protein-DNA complexes; (ii) to benchmark the pairwise alignment of regulatory elements; (iii) to define the confidence limits and the twilight zone of such alignments and (iv) to evaluate the relevance of these thresholds with elements obtained experimentally. We find that the structure of cis elements and protein-DNA interfaces is significantly more conserved than their sequence and measures how this correlates with alignment errors when only sequence information is considered. Our results confirm that DNA motifs in the form of matrices produce better alignments than individual sequences. Finally, we report that empirical and theoretically derived twilight thresholds are useful for estimating the natural plasticity of regulatory sequences, and hence for filtering out unreliable alignments. PMID:23268451

  9. Fast DNA sequence alignment using optical computing

    SciTech Connect

    Yee, M.L.; Craft, D.C.

    1996-11-01

    Alignment of DNA sequences is a necessary step prior to comparison of sequence data. High-speed alignment is needed due to the large size of DNA databases. Correlation, a standard pattern recognition technique, can be used to perform alignment. Correlation can be performed rapidly using optical techniques. Thus, optical correlation offers the potential for high-speed processing of DNA sequence data. This report describes research efforts to apply one-dimensional acousto-optical correlation methods to the problem of DNA sequence alignment. Experimental results are presented.

  10. Triangular Alignment (TAME). A Tensor-based Approach for Higher-order Network Alignment

    SciTech Connect

    Mohammadi, Shahin; Gleich, David F.; Kolda, Tamara G.; Grama, Ananth

    2015-11-01

    Network alignment is an important tool with extensive applications in comparative interactomics. Traditional approaches aim to simultaneously maximize the number of conserved edges and the underlying similarity of aligned entities. We propose a novel formulation of the network alignment problem that extends topological similarity to higher-order structures and provide a new objective function that maximizes the number of aligned substructures. This objective function corresponds to an integer programming problem, which is NP-hard. Consequently, we approximate this objective function as a surrogate function whose maximization results in a tensor eigenvalue problem. Based on this formulation, we present an algorithm called Triangular AlignMEnt (TAME), which attempts to maximize the number of aligned triangles across networks. We focus on alignment of triangles because of their enrichment in complex networks; however, our formulation and resulting algorithms can be applied to general motifs. Using a case study on the NAPABench dataset, we show that TAME is capable of producing alignments with up to 99% accuracy in terms of aligned nodes. We further evaluate our method by aligning yeast and human interactomes. Our results indicate that TAME outperforms the state-of-art alignment methods both in terms of biological and topological quality of the alignments.

  11. The estimated effect of mass or footprint reduction in recent light-duty vehicles on U.S. societal fatality risk per vehicle mile traveled.

    PubMed

    Wenzel, Tom

    2013-10-01

    The National Highway Traffic Safety Administration (NHTSA) recently updated its 2003 and 2010 logistic regression analyses of the effect of a reduction in light-duty vehicle mass on US societal fatality risk per vehicle mile traveled (VMT; Kahane, 2012). Societal fatality risk includes the risk to both the occupants of the case vehicle as well as any crash partner or pedestrians. The current analysis is the most thorough investigation of this issue to date. This paper replicates the Kahane analysis and extends it by testing the sensitivity of his results to changes in the definition of risk, and the data and control variables used in the regression models. An assessment by Lawrence Berkeley National Laboratory (LBNL) indicates that the estimated effect of mass reduction on risk is smaller than in Kahane's previous studies, and is statistically non-significant for all but the lightest cars (Wenzel, 2012a). The estimated effects of a reduction in mass or footprint (i.e. wheelbase times track width) are small relative to other vehicle, driver, and crash variables used in the regression models. The recent historical correlation between mass and footprint is not so large to prohibit including both variables in the same regression model; excluding footprint from the model, i.e. allowing footprint to decrease with mass, increases the estimated detrimental effect of mass reduction on risk in cars and crossover utility vehicles (CUVs)/minivans, but has virtually no effect on light trucks. Analysis by footprint deciles indicates that risk does not consistently increase with reduced mass for vehicles of similar footprint. Finally, the estimated effects of mass and footprint reduction are sensitive to the measure of exposure used (fatalities per induced exposure crash, rather than per VMT), as well as other changes in the data or control variables used. It appears that the safety penalty from lower mass can be mitigated with careful vehicle design, and that manufacturers can reduce mass as a strategy to increase their vehicles' fuel economy and reduce greenhouse gas emissions without necessarily compromising societal safety. PMID:23850544

  12. BCL::Align-sequence alignment and fold recognition with a custom scoring function online.

    PubMed

    Dong, Elizabeth; Smith, Jarrod; Heinze, Sten; Alexander, Nathan; Meiler, Jens

    2008-10-01

    BCL::Align is a multiple sequence alignment tool that utilizes the dynamic programming method in combination with a customizable scoring function for sequence alignment and fold recognition. The scoring function is a weighted sum of the traditional PAM and BLOSUM scoring matrices, position-specific scoring matrices output by PSI-BLAST, secondary structure predicted by a variety of methods, chemical properties, and gap penalties. By adjusting the weights, the method can be tailored for fold recognition or sequence alignment tasks at different levels of sequence identity. A Monte Carlo algorithm was used to determine optimized weight sets for sequence alignment and fold recognition that most accurately reproduced the SABmark reference alignment test set. In an evaluation of sequence alignment performance, BCL::Align ranked best in alignment accuracy (Cline score of 22.90 for sequences in the Twilight Zone) when compared with Align-m, ClustalW, T-Coffee, and MUSCLE. ROC curve analysis indicates BCL::Align's ability to correctly recognize protein folds with over 80% accuracy. The flexibility of the program allows it to be optimized for specific classes of proteins (e.g. membrane proteins) or fold families (e.g. TIM-barrel proteins). BCL::Align is free for academic use and available online at http://www.meilerlab.org/. PMID:18601985

  13. Self-aligned quadruple patterning-aware routing

    NASA Astrophysics Data System (ADS)

    Nakajima, Fumiharu; Kodama, Chikaaki; Ichikawa, Hirotaka; Nakayama, Koichi; Nojima, Shigeki; Kotani, Toshiya

    2014-03-01

    Self-Aligned Quadruple Patterning (SAQP) is one of the most leading techniques in 14 nm node and beyond. However, the construction of feasible layout configurations must follow stricter constraints than in LELELE triple patterning process. Some SAQP layout decomposition methods were recently proposed. However, due to strict constraints required for feasible SAQP layout, the decomposition strategy considering an arbitrary layout does not seem realistic. In this paper, we propose a new routing method for feasible SAQP layout requiring no decomposition. Our method performs detailed routing by correct-by-construction approach and offers compliant layout configuration without any pitch conflict.

  14. Cost-effectiveness analysis of inactivated virosomal subunit influenza vaccination in children aged 3-14 years from the provider and societal perspectives.

    PubMed

    Navas, E; Salleras, L; Domínguez, A; Ibáñez, D; Prat, A; Sentís, J; Garrido, P

    2007-04-20

    The costs and benefits of vaccinating a theoretical cohort of 1000 preschool and school age children (3-14 years) with one dose of inactivated virosomal subunit influenza vaccine in primary health care centers of the Catalan Health Service during the fall annual health examination were compared with the current strategy of no routine vaccination. The economic analysis was carried out from the provider perspective (cost-effectiveness analysis) and from the societal perspective (cost-effectiveness and cost-benefit analysis). The time horizon of the study was established at 6 months. In the base case (cost of vaccination of euro 9.425, cost of paediatric visit plus antibiotic and antipyretic treatment of euro 42.50, cost of 1 day of hospital stay of euro 454.25, cost of the work lost by the mother to take care of her ill child of euro 29.2 and cost of 1 year of quality adjusted life year lost of euro 10,662), the vaccination does not save money from the provider perspective (net present value=euro-1460.51), but the cost-effectiveness ratios are very reasonable (euro 5.80 per episode of acute febrile respiratory process avoided and euro 18.26 per quality adjusted life year saved). From the societal perspective, the vaccination saves money (net present value=euro+7587.03) and the benefit-cost ratio is 1.80, meaning that euro 0.80 is saved per euro invested. Our study shows that vaccination of children 3-14 years old with a single dose of inactivated subunit influenza vaccine in primary health care centers during the fall annual health examination provides socioeconomic benefits to the society in addition to substantial health benefits for the child. PMID:17324489

  15. Precision aligned split V-block

    DOEpatents

    George, Irwin S. (3240 Siringo Rd., Santa Fe, NM 87501)

    1984-01-01

    A precision aligned split V-block for holding a workpiece during a milling operation having an expandable frame for allowing various sized workpieces to be accommodated, is easily secured directly to the mill table and having key lugs in one base of the split V-block that assures constant alignment.

  16. Probabilistic sequence alignment of stratigraphic records

    NASA Astrophysics Data System (ADS)

    Lin, Luan; Khider, Deborah; Lisiecki, Lorraine E.; Lawrence, Charles E.

    2014-10-01

    The assessment of age uncertainty in stratigraphically aligned records is a pressing need in paleoceanographic research. The alignment of ocean sediment cores is used to develop mutually consistent age models for climate proxies and is often based on the δ18O of calcite from benthic foraminifera, which records a global ice volume and deep water temperature signal. To date, δ18O alignment has been performed by manual, qualitative comparison or by deterministic algorithms. Here we present a hidden Markov model (HMM) probabilistic algorithm to find 95% confidence bands for δ18O alignment. This model considers the probability of every possible alignment based on its fit to the δ18O data and transition probabilities for sedimentation rate changes obtained from radiocarbon-based estimates for 37 cores. Uncertainty is assessed using a stochastic back trace recursion to sample alignments in exact proportion to their probability. We applied the algorithm to align 35 late Pleistocene records to a global benthic δ18O stack and found that the mean width of 95% confidence intervals varies between 3 and 23 kyr depending on the resolution and noisiness of the record's δ18O signal. Confidence bands within individual cores also vary greatly, ranging from ~0 to >40 kyr. These alignment uncertainty estimates will allow researchers to examine the robustness of their conclusions, including the statistical evaluation of lead-lag relationships between events observed in different cores.

  17. Galaxy Alignments: Observations and Impact on Cosmology

    NASA Astrophysics Data System (ADS)

    Kirk, Donnacha; Brown, Michael L.; Hoekstra, Henk; Joachimi, Benjamin; Kitching, Thomas D.; Mandelbaum, Rachel; Sifón, Cristóbal; Cacciato, Marcello; Choi, Ami; Kiessling, Alina; Leonard, Adrienne; Rassat, Anais; Schäfer, Björn Malte

    2015-11-01

    Galaxy shapes are not randomly oriented, rather they are statistically aligned in a way that can depend on formation environment, history and galaxy type. Studying the alignment of galaxies can therefore deliver important information about the physics of galaxy formation and evolution as well as the growth of structure in the Universe. In this review paper we summarise key measurements of galaxy alignments, divided by galaxy type, scale and environment. We also cover the statistics and formalism necessary to understand the observations in the literature. With the emergence of weak gravitational lensing as a precision probe of cosmology, galaxy alignments have taken on an added importance because they can mimic cosmic shear, the effect of gravitational lensing by large-scale structure on observed galaxy shapes. This makes galaxy alignments, commonly referred to as intrinsic alignments, an important systematic effect in weak lensing studies. We quantify the impact of intrinsic alignments on cosmic shear surveys and finish by reviewing practical mitigation techniques which attempt to remove contamination by intrinsic alignments.

  18. Nonvisual Cues for Aligning to Cross Streets

    ERIC Educational Resources Information Center

    Scott, Alan C.; Barlow, Janet M.; Guth, David A.; Bentzen, Billie Louise; Cunningham, Christopher M.; Long, Richard

    2011-01-01

    Accurately aligning to a crosswalk is an important component of safe street crossing for pedestrians who are blind. Six alignment cues were evaluated in a simulated crosswalk environment in which the angle of the crosswalk was not always in line with the slope of the ramp. The effectiveness of each cue is reported and implications are discussed.…

  19. Achieving Organisational Change through Values Alignment

    ERIC Educational Resources Information Center

    Branson, Christopher M.

    2008-01-01

    Purpose: The purpose of this paper is to, first, establish the interdependency between the successful achievement of organisational change and the attainment of values alignment within an organisation's culture and then, second, to describe an effective means for attaining such values alignment. Design/methodology/approach: Literature from the…

  20. Partial Automated Alignment and Integration System

    NASA Technical Reports Server (NTRS)

    Kelley, Gary Wayne (Inventor)

    2014-01-01

    The present invention is a Partial Automated Alignment and Integration System (PAAIS) used to automate the alignment and integration of space vehicle components. A PAAIS includes ground support apparatuses, a track assembly with a plurality of energy-emitting components and an energy-receiving component containing a plurality of energy-receiving surfaces. Communication components and processors allow communication and feedback through PAAIS.

  1. Phylogenetic Inference From Conserved sites Alignments

    SciTech Connect

    grundy, W.N.; Naylor, G.J.P.

    1999-08-15

    Molecular sequences provide a rich source of data for inferring the phylogenetic relationships among species. However, recent work indicates that even an accurate multiple alignment of a large sequence set may yield an incorrect phylogeny and that the quality of the phylogenetic tree improves when the input consists only of the highly conserved, motif regions of the alignment. This work introduces two methods of producing multiple alignments that include only the conserved regions of the initial alignment. The first method retains conserved motifs, whereas the second retains individual conserved sites in the initial alignment. Using parsimony analysis on a mitochondrial data set containing 19 species among which the phylogenetic relationships are widely accepted, both conserved alignment methods produce better phylogenetic trees than the complete alignment. Unlike any of the 19 inference methods used before to analyze this data, both methods produce trees that are completely consistent with the known phylogeny. The motif-based method employs far fewer alignment sites for comparable error rates. For a larger data set containing mitochondrial sequences from 39 species, the site-based method produces a phylogenetic tree that is largely consistent with known phylogenetic relationships and suggests several novel placements.

  2. Achieving Organisational Change through Values Alignment

    ERIC Educational Resources Information Center

    Branson, Christopher M.

    2008-01-01

    Purpose: The purpose of this paper is to, first, establish the interdependency between the successful achievement of organisational change and the attainment of values alignment within an organisation's culture and then, second, to describe an effective means for attaining such values alignment. Design/methodology/approach: Literature from the…

  3. Evaluating Content Alignment in Computerized Adaptive Testing

    ERIC Educational Resources Information Center

    Wise, Steven L.; Kingsbury, G. Gage; Webb, Norman L.

    2015-01-01

    The alignment between a test and the content domain it measures represents key evidence for the validation of test score inferences. Although procedures have been developed for evaluating the content alignment of linear tests, these procedures are not readily applicable to computerized adaptive tests (CATs), which require large item pools and do…

  4. Evaluating Content Alignment in Computerized Adaptive Testing

    ERIC Educational Resources Information Center

    Wise, Steven L.; Kingsbury, G. Gage; Webb, Norman L.

    2015-01-01

    The alignment between a test and the content domain it measures represents key evidence for the validation of test score inferences. Although procedures have been developed for evaluating the content alignment of linear tests, these procedures are not readily applicable to computerized adaptive tests (CATs), which require large item pools and do…

  5. Automated alignment of optical components for high-power diode lasers

    NASA Astrophysics Data System (ADS)

    Brecher, C.; Pyschny, N.; Haag, S.; Guerrero Lule, V.

    2012-03-01

    Despite major progress in developing brilliant laser sources a huge potential for cost reductions can be found in simpler setups and automated assembly processes, especially for large volume applications. In this presentation, a concept for flexible automation in optics assembly is presented which is based on standard micro assembly systems with relatively large workspace and modular micromanipulators to enhance the system with additional degrees of freedom and a very high motion resolution. The core component is a compact flexure-based micromanipulator especially designed for the alignment of micro optical components which will be described in detail. The manipulator has been applied in different scenarios to develop and investigate automated alignment processes. This paper focuses on the automated alignment of fast axis collimation (FAC) lenses which is a crucial step during the production of diode lasers. The handling and positioning system, the measuring arrangement for process feedback during active alignment as well as the alignment strategy will be described. The fine alignment of the FAC lens is performed with the micromanipulator under concurrent analysis of the far and the near field intensity distribution. An optimization of the image processing chains for the alignment of a FAC in front of a diode bar led to cycle times of less than 30 seconds. An outlook on other applications and future work regarding the development of automated assembly processes as well as new ideas for flexible assembly systems with desktop robots will close the talk.

  6. AIMFAST : an alignment tool based on fringe reflection methods applied to dish concentrators.

    SciTech Connect

    Yellowhair, Julius; Stone, Brad; Myer, Brian; Hunt, Kirby; Trapeznikov, Kirill; Andraka, Charles E.; Carlson, Jeffrey J.

    2010-08-01

    The proper alignment of facets on a dish engine concentrated solar power system is critical to the performance of the system. These systems are generally highly concentrating to produce high temperatures for maximum thermal efficiency so there is little tolerance for poor optical alignment. Improper alignment can lead to poor performance and shortened life through excessively high flux on the receiver surfaces, imbalanced power on multicylinder engines, and intercept losses at the aperture. Alignment approaches used in the past are time consuming field operations, typically taking 4-6 h per dish with 40-80 facets on the dish. Production systems of faceted dishes will need rapid, accurate alignment implemented in a fraction of an hour. In this paper, we present an extension to our Sandia Optical Fringe Analysis Slope Technique mirror characterization system that will automatically acquire data, implement an alignment strategy, and provide real-time mirror angle corrections to actuators or labor beneath the dish. The Alignment Implementation for Manufacturing using Fringe Analysis Slope Technique (AIMFAST) has been implemented and tested at the prototype level. In this paper we present the approach used in AIMFAST to rapidly characterize the dish system and provide near-real-time adjustment updates for each facet. The implemented approach can provide adjustment updates every 5 s, suitable for manual or automated adjustment of facets on a dish assembly line.

  7. ?-? interaction-induced vertical alignment of silica mesochannels templated by a discotic lyotropic liquid crystal.

    PubMed

    Hara, Mitsuo; Nagano, Shusaku; Seki, Takahiro

    2010-10-01

    The development of vertically aligned mesochannels in organic/inorganic hybrid films is in high demand and a challenging issue. However, there are no clear guiding principles to attain the surface-mediated vertical alignment. This work proposes the first clear versatile strategy to achieve the vertical alignment by utilizing the ?-? interaction between the organic template molecule of a planar discotic liquid crystalline and 2D ?-plane of graphite. The crucial role of the ?-? interaction can be verified by the exploration with other substrates such as silicon wafer surfaces with varied surface energy (water contact angle: 5°-105°), quartz plates, and polymer films, which provided common parallel alignment with respect to the substrate plane. PMID:20836502

  8. The Ribosomal Database Project: improved alignments and new tools for rRNA analysis.

    PubMed

    Cole, J R; Wang, Q; Cardenas, E; Fish, J; Chai, B; Farris, R J; Kulam-Syed-Mohideen, A S; McGarrell, D M; Marsh, T; Garrity, G M; Tiedje, J M

    2009-01-01

    The Ribosomal Database Project (RDP) provides researchers with quality-controlled bacterial and archaeal small subunit rRNA alignments and analysis tools. An improved alignment strategy uses the Infernal secondary structure aware aligner to provide a more consistent higher quality alignment and faster processing of user sequences. Substantial new analysis features include a new Pyrosequencing Pipeline that provides tools to support analysis of ultra high-throughput rRNA sequencing data. This pipeline offers a collection of tools that automate the data processing and simplify the computationally intensive analysis of large sequencing libraries. In addition, a new Taxomatic visualization tool allows rapid visualization of taxonomic inconsistencies and suggests corrections, and a new class Assignment Generator provides instructors with a lesson plan and individualized teaching materials. Details about RDP data and analytical functions can be found at http://rdp.cme.msu.edu/. PMID:19004872

  9. The Ribosomal Database Project: improved alignments and new tools for rRNA analysis

    PubMed Central

    Cole, J. R.; Wang, Q.; Cardenas, E.; Fish, J.; Chai, B.; Farris, R. J.; Kulam-Syed-Mohideen, A. S.; McGarrell, D. M.; Marsh, T.; Garrity, G. M.; Tiedje, J. M.

    2009-01-01

    The Ribosomal Database Project (RDP) provides researchers with quality-controlled bacterial and archaeal small subunit rRNA alignments and analysis tools. An improved alignment strategy uses the Infernal secondary structure aware aligner to provide a more consistent higher quality alignment and faster processing of user sequences. Substantial new analysis features include a new Pyrosequencing Pipeline that provides tools to support analysis of ultra high-throughput rRNA sequencing data. This pipeline offers a collection of tools that automate the data processing and simplify the computationally intensive analysis of large sequencing libraries. In addition, a new Taxomatic visualization tool allows rapid visualization of taxonomic inconsistencies and suggests corrections, and a new class Assignment Generator provides instructors with a lesson plan and individualized teaching materials. Details about RDP data and analytical functions can be found at http://rdp.cme.msu.edu/. PMID:19004872

  10. Bilinear decomposition based alignment of chromatographic profiles.

    PubMed

    Tistaert, Christophe; Vander Heyden, Yvan

    2012-07-01

    A novel alignment procedure for chromatographic signals with photodiode array detection is presented. At first, the complexity of the chromatographic signals is reduced by chemometric resolution of the pure constituents. For this, the application of multivariate curve resolution-alternating least squares leads to the decomposition of the multiway data block into a chemically meaningful bilinear model representing the chromatographic profiles and their spectral signatures. The flexible implementation of a spectral selectivity constraint allows the background to be differentiated from the constituent spectra. Hereby, the pure concentration profiles are obtained which are consequently individually aligned by correlation optimized warping. In its final step, the procedure reconstitutes the original data with the aligned chromatographic profiles and their corresponding spectra. The alignment is evaluated for two sets of chromatographic signals. The new procedure improves the original application of correlation optimized warping minimizing the risks of aligning noncorresponding chromatographic information. PMID:22724456

  11. Automated interferometric alignment system for paraboloidal mirrors

    DOEpatents

    Maxey, L. Curtis (Powell, TN)

    1993-01-01

    A method is described for a systematic method of interpreting interference fringes obtained by using a corner cube retroreflector as an alignment aid when aigning a paraboloid to a spherical wavefront. This is applicable to any general case where such alignment is required, but is specifically applicable in the case of aligning an autocollimating test using a diverging beam wavefront. In addition, the method provides information which can be systematically interpreted such that independent information about pitch, yaw and focus errors can be obtained. Thus, the system lends itself readily to automation. Finally, although the method is developed specifically for paraboloids, it can be seen to be applicable to a variety of other aspheric optics when applied in combination with a wavefront corrector that produces a wavefront which, when reflected from the correctly aligned aspheric surface will produce a collimated wavefront like that obtained from the paraboloid when it is correctly aligned to a spherical wavefront.

  12. Vane segment support and alignment device

    DOEpatents

    McLaurin, L.D.; Sizemore, J.D.

    1999-07-13

    A support and alignment assembly for supporting and aligning a vane segment is provided. The support and alignment assembly comprises a torque plate which defines an opening for receiving an eccentric pin and a locking end member for receiving a lock socket member. An eccentric pin adjustably supported by the torque plate opening for supporting and aligning a vane segment is provided. A lock socket member adapted to securely receive the eccentric pin and rotated therewith, and adjustably engage the torque plate locking end is provided. The lock socket member receives the eccentric pin, such that when the eccentric pin is adjusted to align the vane segment, the lock socket member engages the torque plate locking end to secure the vane segment in the desired position. 5 figs.

  13. Vane segment support and alignment device

    DOEpatents

    McLaurin, Leroy Dixon (Winter Springs, FL); Sizemore, John Derek (Orlando, FL)

    1999-01-01

    A support and alignment assembly for supporting and aligning a vane segment is provided. The support and alignment assembly comprises a torque plate which defines an opening for receiving an eccentric pin and a locking end member for receiving a lock socket member. An eccentric pin adjustably supported by the torque plate opening for supporting and aligning a vane segment is provided. A lock socket member adapted to securely receive the eccentric pin and rotated therewith, and adjustably engage the torque plate locking end is provided. The lock socket member receives the eccentric pin, such that when the eccentric pin is adjusted to align the vane segment, the lock socket member engages the torque plate locking end to secure the vane segment in the desired position.

  14. Aligning Greek-English parallel texts

    NASA Astrophysics Data System (ADS)

    Galiotou, Eleni; Koronakis, George; Lazari, Vassiliki

    2015-02-01

    In this paper, we discuss issues concerning the alignment of parallel texts written in languages with different alphabets based on an experiment of aligning texts from the proceedings of the European Parliament in Greek and English. First, we describe our implementation of the k-vec algorithm and its application to the bilingual corpus. Then the output of the algorithm is used as a starting point for an alignment procedure at a sentence level which also takes into account mark-ups of meta-information. The results of the implementation are compared to those of the application of the Church and Gale alignment algorithm on the Europarl corpus. The conclusions of this comparison can give useful insights as for the efficiency of alignment algorithms when applied to the particular bilingual corpus.

  15. R3D Align: global pairwise alignment of RNA 3D structures using local superpositions

    PubMed Central

    Rahrig, Ryan R.; Leontis, Neocles B.; Zirbel, Craig L.

    2010-01-01

    Motivation: Comparing 3D structures of homologous RNA molecules yields information about sequence and structural variability. To compare large RNA 3D structures, accurate automatic comparison tools are needed. In this article, we introduce a new algorithm and web server to align large homologous RNA structures nucleotide by nucleotide using local superpositions that accommodate the flexibility of RNA molecules. Local alignments are merged to form a global alignment by employing a maximum clique algorithm on a specially defined graph that we call the ‘local alignment’ graph. Results: The algorithm is implemented in a program suite and web server called ‘R3D Align’. The R3D Align alignment of homologous 3D structures of 5S, 16S and 23S rRNA was compared to a high-quality hand alignment. A full comparison of the 16S alignment with the other state-of-the-art methods is also provided. The R3D Align program suite includes new diagnostic tools for the structural evaluation of RNA alignments. The R3D Align alignments were compared to those produced by other programs and were found to be the most accurate, in comparison with a high quality hand-crafted alignment and in conjunction with a series of other diagnostics presented. The number of aligned base pairs as well as measures of geometric similarity are used to evaluate the accuracy of the alignments. Availability: R3D Align is freely available through a web server http://rna.bgsu.edu/R3DAlign. The MATLAB source code of the program suite is also freely available for download at that location. Supplementary information: Supplementary data are available at Bioinformatics online. Contact: r-rahrig@onu.edu PMID:20929913

  16. Clear aligners for orthodontic treatment?

    PubMed

    Javidi, Hanieh; Graham, Elizabeth

    2015-12-01

    Data sourcesPubMed/Medline, Embase, Cochrane Central Register of Controlled Clinical trials (CENTRAL), Web of Knowledge, SCOPUS, Google Scholar and LILACS databases.Study selectionClinical prospective and retrospective studies of orthodontic treatment with clear aligners on patients over the age of 15 that included clear descriptions of the materials and applied technique were included. Selection was undertaken independently by two reviewers.Data extraction and synthesisTwo reviewers extracted data independently with study quality being assessed using the grading system described by the Swedish Council on Technology Assessment in Health Care (SBU). A narrative summary of the findings was presented.ResultsEleven studies involving a total of 480 patients were included consisting of two randomised controlled trials, five prospective studies and four retrospective studies. Six studies were considered to be of moderate quality, the remainder of limited quality.ConclusionsMost of the studies presented with methodological problems: small sample size, bias and confounding variables, lack of method error analysis, blinding in measurements, and deficient or missing statistical methods. The quality level of the studies was not sufficient to draw any evidence-based conclusions. PMID:26680520

  17. Learning Peptide-Spectrum Alignment Models for Tandem Mass Spectrometry.

    PubMed

    Halloran, John T; Bilmes, Jeff A; Noble, William S

    2014-01-01

    We present a peptide-spectrum alignment strategy that employs a dynamic Bayesian network (DBN) for the identification of spectra produced by tandem mass spectrometry (MS/MS). Our method is fundamentally generative in that it models peptide fragmentation in MS/MS as a physical process. The model traverses an observed MS/MS spectrum and a peptide-based theoretical spectrum to calculate the best alignment between the two spectra. Unlike all existing state-of-the-art methods for spectrum identification that we are aware of, our method can learn alignment probabilities given a dataset of high-quality peptide-spectrum pairs. The method, moreover, accounts for noise peaks and absent theoretical peaks in the observed spectrum. We demonstrate that our method outperforms, on a majority of datasets, several widely used, state-of-the-art database search tools for spectrum identification. Furthermore, the proposed approach provides an extensible framework for MS/MS analysis and provides useful information that is not produced by other methods, thanks to its generative structure. PMID:25298752

  18. Learning Peptide-Spectrum Alignment Models for Tandem Mass Spectrometry

    PubMed Central

    Halloran, John T.; Bilmes, Jeff A.; Noble, William S.

    2014-01-01

    We present a peptide-spectrum alignment strategy that employs a dynamic Bayesian network (DBN) for the identification of spectra produced by tandem mass spectrometry (MS/MS). Our method is fundamentally generative in that it models peptide fragmentation in MS/MS as a physical process. The model traverses an observed MS/MS spectrum and a peptide-based theoretical spectrum to calculate the best alignment between the two spectra. Unlike all existing state-of-the-art methods for spectrum identification that we are aware of, our method can learn alignment probabilities given a dataset of high-quality peptide-spectrum pairs. The method, moreover, accounts for noise peaks and absent theoretical peaks in the observed spectrum. We demonstrate that our method outperforms, on a majority of datasets, several widely used, state-of-the-art database search tools for spectrum identification. Furthermore, the proposed approach provides an extensible framework for MS/MS analysis and provides useful information that is not produced by other methods, thanks to its generative structure. PMID:25298752

  19. A Statistical Algorithm for Assessing Cellular Alignment

    PubMed Central

    Nectow, Alexander R.; Gil, Eun Seok; Kaplan, David L.; Kilmer, Misha E.

    2013-01-01

    Current statistical techniques for analyzing cellular alignment data in the fields of biomaterials and tissue engineering are limited due to heuristic and less quantitative approaches. For example, generally a cut-off degree limit (commonly 20 degrees), is arbitrarily defined within which cells are considered ‘aligned.’ The effectiveness of a patterned biomaterial in guiding the alignment of cells, such as neurons, is often critical to predict relationships between the biomaterial design and biological outcomes, both in vitro and in vivo. This becomes particularly important in the case of peripheral neurons, which require precise axon guidance to obtain successful regenerative outcomes. To address this issue, we have developed a protocol for processing cellular alignment data sets, which implicitly determines an ‘angle of alignment.’ This was accomplished as follows: cells ‘aligning’ with an underlying, anisotropic scaffold display uniformly distributed angles up to a cut-off point determined by how effective the biomaterial is in aligning cells. Therefore, this fact was then used to determine where an alignment angle data set diverges from a uniform distribution. This was accomplished by measuring the spacing between the collected, increasingly ordered angles and analyzing their underlying distributions using a normalized cumulative periodogram (NCP)-criterion. The proposed protocol offers a novel way to implicitly define cellular alignment, with respect to various anisotropic biomaterials. This method may also offer an alternative to assess cellular alignment, which could offer improved predictive measures related to biological outcomes. Further, the approach described can be used for a broad range of cell types grown on 2D surfaces, but would not be applicable to 3D scaffold systems in the present format. PMID:23008168

  20. Aligned Nanofibers for Regenerating Arteries, Nerves, and Muscles

    NASA Astrophysics Data System (ADS)

    McClendon, Mark Trosper

    Cells are the fundamental unit of the human body, and therefore the ability to control cell behavior is the most important challenge in regenerative medicine. Peptides are the language of biology which is why synthetic peptide amphiphile (PA) molecules hold great potential as a biomaterial. The work presented in this dissertation explores a variety of liquid crystalline PA nanofibers as a means for directing cell growth. Shaping the alignment of these nanofiber networks requires a deep understanding of their rheological properties which presents a difficult challenge as they exist in complex solid and liquid environments. Using PA molecules that self-assemble into high aspect ratio nanofibers and liquid crystalline solutions, this work investigates the influence of shear flow on macroscopic and microscopic nanofiber alignment. To this end, a shear force applied to PA solutions was systematically varied while the alignment was probed using small angle x-ray scattering. Nanofibers were found to respond to shear flow by aligning parallel to the flow direction. By changing pH and PA chemical sequence it was observed that increasing the interfiber electrostatic repulsive interactions resulted in a greater dependence on shear rate. Nanofiber solutions having greater repulsion did not drastically increase in alignment when the applied strain was increased by two orders of magnitude (1 s -1 to 100 s-1), while solutions with nanofibers having less repulsion increased there alignment four fold with the same strain increase. say exactly what you mean by resulted in greater dependence: did it result in fibers aligning under lower shear rates or higher rates--give the results Anionic PA solutions typically used to encapsulate living cells at neutral pH were found to require minimal shear rates, <1s-1, to achieve significant nanofiber alignment. In an effort to produce tubular hydrogels composed of circumferentially aligned nanofibers, a procedure was designed that used an annular gap containing PA solution with a rotating rod. Using the shear aligning properties of PA solutions this rotating surface in contact with the PA solution induced a high degree of alignment in the nanofibers which was subsequently locked in place by introducing gelating calcium ions. again say something about what this fabrication procedure entails Cells encapsulated within these tubes responded to the alignment by extending in the circumferential direction mimicking the same cellular alignment observed in native arteries. A similar design strategy was also used to align nanofibers within the core of biopolymer nerve conduits, and these scaffolds were implanted in a rat sciatic nerve model. Histological and behavioral observations confirmed that PA implants sustained regeneration rates comparable to autologous grafts and significantly better than empty biopolymer grafts. Furthermore, these nanofiber gels were used as a vehicle to deliver stem cells into muscle tissue. A specialized injector was designed to introduce aligned PA gels into mouse leg muscles in a 1cm long channel. Bioluminescence and histology showed that stem cell engraftment into myofibers was greatly enhanced when delivered by PA gels compared to saline solution. The final section of this thesis describes a new series of PA molecules designed to degrade upon exposure to UV lightstate here why is this of interest in the context of the work described in the thesis. This was done to understand the degradation behavior of PA nanofibers and provide a controlled approach to changing the rheological properties post gelation.The three PA molecules in this series contained the same peptide sequence V3A3E3, while varying the location of a nitrobenzyl UV-reactive group along the backbone of the molecule. This system allowed for a quick reaction that cleaves the molecule at the reactive nitrobenzyl site without introducing any other reactive molecules. While all three molecules produced nanofibers that remained intact upon UV exposure, the PA having its cleavage point nearest to the hydrophobic core resulted in the most dramatic drop in storage modulus. This work has demonstrated the control of alignment, macroscopic shape, and rheological properties of nanofiber gels tailored to assist in the regeneration of tissues with orientational order such as blood vessels, peripheral nerves, and muscle tissue.

  1. When Weather Matters: Science and Service to Meet Critical Societal Needs

    NASA Technical Reports Server (NTRS)

    2010-01-01

    The goal of weather prediction is to provide information people and organizations can use to reduce weather-related losses and enhance societal benefits, including protection of life and property, public health and safety, and support of economic prosperity and quality of life. In economic terms, the benefit of the investment in public weather forecasts and warnings is substantial: the estimated annualized benefit is about $31.5 billion, compared to the $5.1 billion cost of generating the information. Between 1980 and 2009, 96 weather disasters in the United States each caused at least $1 billion in damages, with total losses exceeding $700 billion. Between 1999 and 2008, there were an average of 629 direct weather fatalities per year. The annual impacts of adverse weather on the national highway system and roads are staggering: 1.5 million weather-related crashes with 7,400 deaths, more than 700,000 injuries, and $42 billion in economic losses.

  2. The changing face of work in the United States: implications for individual, institutional, and societal survival.

    PubMed

    Sue, D W; Parham, T A; Santiago, G B

    1998-01-01

    Changes in the world of work are posing major challenges to workers, institutions, and society. Not only has the nature of work been affected by the changing work environment, increased global competition, and technological revolutions, but the characteristics of the workforce can only be described as revolutionary. Societal forces have resulted in what the authors call the "changing complexion of the workforce", the "feminization of the workforce", and the "graying of the workforce". Traditional theories of work motivation, employer-employee relations, and the role of psychology must also evolve to accommodate this challenge. The collision of these structural and demographic forces has resulted in major upheaval in society and the world of work. The authors discuss implications of these changes and urge psychologists to use their accumulated knowledge and wisdom to positively impact social policy for the greater good of people, institutions, and society. PMID:9713157

  3. The Societal Impacts of a Mars Mission in the Future of Space Exploration

    NASA Astrophysics Data System (ADS)

    Shaghaghi, Azam; Antonakopoulos, Konstantinos

    The human race has evolved, grown and expanded through the exploration of Earth. After initial steps on the Moon, our next challenge is to explore the solar system. From the Mars mission viewpoint stepping on this planet will bring social impacts which may influence the society to a great extent. Never before have there been so complex mission settings. This implies as an inherent impediment for the future of space exploration since it is most likely to be scrutinized and challenged by the public. The goal of this paper is to outline the societal impacts of a Mars mission in the future of space exploration by first introducing the existing challenges and then identifying the primary groups that form public opinion and concludes where efforts should be focused.

  4. Senior Seminar Focusing on Societal Issues Related to Chemistry and Biochemistry

    NASA Astrophysics Data System (ADS)

    White, Harold B., III; Johnston, Murray V.; Panar, Manuel

    2000-12-01

    The lack of a clearly defined content or structure provided the opportunity to transform a one-credit, pass-fail senior seminar course into a meaningful capstone experience for chemistry and biochemistry majors. In addition to individual and class exercises associated with employment, graduate school, communication skills, and professional ethics, small groups of students worked together to create informative Web sites that took positions on important societal issues related to chemistry. Each group presented a seminar and responded to questions from their peers and two or more unannounced visitors, "wild cards" who often had expertise in the seminar topic. Throughout the course, the instructors placed particular emphasis on developing students' ability to work cooperatively, locate and evaluate information, make informed judgments based on available information, and logically develop and defend their positions. Input from a retired industrial chemist helped define these skill elements.

  5. The Societal Impact of Extraterrestrial Life: The Relevance of History and the Social Sciences

    NASA Astrophysics Data System (ADS)

    Dick, Steven J.

    This chapter reviews past studies on the societal impact of extraterrestrial life and offers four related ways in which history is relevant to the subject: the history of impact thus far, analogical reasoning, impact studies in other areas of science and technology, and studies on the nature of discovery and exploration. We focus particularly on the promise and peril of analogical arguments, since they are by necessity widespread in the field. This chapter also summarizes the relevance of the social sciences, particularly anthropology and sociology, and concludes by taking a closer look at the possible impact of the discovery of extraterrestrial life on theology and philosophy. In undertaking this study we emphasize three bedrock principles: (1) we cannot predict the future; (2) society is not monolithic, implying many impacts depending on religion, culture and worldview; (3) the impact of any discovery of extraterrestrial life is scenario-dependent.

  6. Societal impact of bilirubin-induced hearing impairment in resource-limited nations.

    PubMed

    Olusanya, Bolajoko O

    2015-02-01

    Infants with bilirubin-induced neurologic dysfunction (BIND) are characterized by several developmental disabilities including auditory impairments. This paper explores the societal impact of bilirubin-induced auditory impairments, inclusive of hearing impairments and auditory neuropathy spectrum disorders, on these infants, their families, and on the community in resource-limited countries (per capita income of US$6,000 or less). Auditory impairments have substantial emotional, social, and economic impact on the affected infants, their families and communities. The burden is exacerbated by widespread poverty, unfavorable community attitudes towards disabilities, and lack of requisite health, educational, and social services. Curtailing the incidence of avoidable severe hyperbilirubinemia through proactive and effective management of infants at risk or with severe hyperbilirubinemia is necessary at all levels of healthcare delivery. Early detection and intervention for unavoidable auditory impairments should be widely promoted to provide improved developmental trajectories for the affected infants. PMID:25573775

  7. A priority paper for the societal and ethical aspects of synthetic biology.

    PubMed

    Schmidt, Markus; Ganguli-Mitra, Agomoni; Torgersen, Helge; Kelle, Alexander; Deplazes, Anna; Biller-Andorno, Nikola

    2009-12-01

    As synthetic biology develops into a promising science and engineering field, we need to have clear ideas and priorities regarding its safety, security, ethical and public dialogue implications. Based on an extensive literature search, interviews with scientists, social scientists, a 4 week long public e-forum, and consultation with several stakeholders from science, industry and civil society organisations, we compiled a list of priority topics regarding societal issues of synthetic biology for the years ahead. The points presented here are intended to encourage all stakeholders to engage in the prioritisation of these issues and to participate in a continuous dialogue, with the ultimate goal of providing a basis for a multi-stakeholder governance in synthetic biology. Here we show possible ways to solve the challenges to synthetic biology in the field of safety, security, ethics and the science-public interface. PMID:19816794

  8. Hotspots of coastal vulnerability: A DPSIR analysis to find societal pathways and responses

    NASA Astrophysics Data System (ADS)

    Newton, Alice; Weichselgartner, Juergen

    2014-03-01

    Dramatic loss of life and economic losses in coastal zones have focused attention on natural and man-made hazards. The paper starts with a review of the coastal vulnerability terminology. Coastal zones are then presented as complex, socio-ecological systems. Four main coastal hotspots of vulnerability; namely Arctic coasts, small islands, river-mouth systems and urban coasts (including megacities) are analysed to demonstrate the complexity of coastal vulnerability. A DPSIR framework is used to explore the causes and consequences of coastal vulnerability. The paper then focuses in particular on societal, as well as floods, storm-surges and tsunamis to technological and engineering solutions. These include raising awareness, advancing forecasting, enhancing preparedness and improving governance.

  9. Impact of changing societal trends on the spread of infections in American and Canadian homes.

    PubMed

    Sattar, S A; Tetro, J; Springthorpe, V S

    1999-12-01

    Infectious diseases continue to exert a heavy toll on human health even in industrialized countries. Recent data from the World Health Organization suggests that infectious diseases are the leading cause of death in the world. Many changing trends in our society have a known or potential impact on infectious disease spread and may have an impact on the normal routine of home hygiene. Important amongst these societal trends are increasing population and life expectancy, changes in urbanization, grouping of susceptibles, increased ambulatory and home care, increased immunosuppression, increased and faster travel, changes in technology, increasing antibiotic resistance as a result of misuse of antibiotics, changes in food and water consumption, and changes in personal cleaning, washing, and laundry practices. This review will highlight these factors and their impact on home hygiene and steps that may be needed to reduce the risk from infections. PMID:10586141

  10. Structural determinants of the abortion rate: a cross-societal analysis.

    PubMed

    Trent, K; Hoskin, A W

    1999-01-01

    Data for a sample of 89 countries are used to examine societal-level predictors of the legal status of abortion and its incidence as indicated by abortion rates. Measures of socioeconomic development, women's labor force participation, and dominant religion are considered as predictors of abortion. Logistic regression analysis reveals that socioeconomic development has a positive effect on the probability of abortion being legal. Both a greater dominance of Catholicism and Islam in a society reduce the probability that abortion is legal. Results of tobit analyses show that development has curvilinear effects on abortion rates, with lower rates of abortion at both the lower and higher ends of development. Findings also indicate a positive effect of female labor force participation on the abortion rate that initially grows stronger with increases in socioeconomic development, but weakens with further increases. Finally, a greater proportion of Catholics in a population lowers the abortion rate. PMID:10842502

  11. High quality protein sequence alignment by combining structural profile prediction and profile alignment using SABERTOOTH

    PubMed Central

    2010-01-01

    Background Protein alignments are an essential tool for many bioinformatics analyses. While sequence alignments are accurate for proteins of high sequence similarity, they become unreliable as they approach the so-called 'twilight zone' where sequence similarity gets indistinguishable from random. For such distant pairs, structure alignment is of much better quality. Nevertheless, sequence alignment is the only choice in the majority of cases where structural data is not available. This situation demands development of methods that extend the applicability of accurate sequence alignment to distantly related proteins. Results We develop a sequence alignment method that combines the prediction of a structural profile based on the protein's sequence with the alignment of that profile using our recently published alignment tool SABERTOOTH. In particular, we predict the contact vector of protein structures using an artificial neural network based on position-specific scoring matrices generated by PSI-BLAST and align these predicted contact vectors. The resulting sequence alignments are assessed using two different tests: First, we assess the alignment quality by measuring the derived structural similarity for cases in which structures are available. In a second test, we quantify the ability of the significance score of the alignments to recognize structural and evolutionary relationships. As a benchmark we use a representative set of the SCOP (structural classification of proteins) database, with similarities ranging from closely related proteins at SCOP family level, to very distantly related proteins at SCOP fold level. Comparing these results with some prominent sequence alignment tools, we find that SABERTOOTH produces sequence alignments of better quality than those of Clustal W, T-Coffee, MUSCLE, and PSI-BLAST. HHpred, one of the most sophisticated and computationally expensive tools available, outperforms our alignment algorithm at family and superfamily levels, while the use of SABERTOOTH is advantageous for alignments at fold level. Our alignment scheme will profit from future improvements of structural profiles prediction. Conclusions We present the automatic sequence alignment tool SABERTOOTH that computes pairwise sequence alignments of very high quality. SABERTOOTH is especially advantageous when applied to alignments of remotely related proteins. The source code is available at http://www.fkp.tu-darmstadt.de/sabertooth_project/, free for academic users upon request. PMID:20470364

  12. Cost-Effectiveness of Treatments for Relapsing Remitting Multiple Sclerosis: A French Societal Perspective

    PubMed Central

    Chevalier, Julie; Chamoux, Catherine; Hammès, Florence; Chicoye, Annie

    2016-01-01

    Objectives The paper aimed to estimate the incremental cost-effectiveness ratio (ICER) at the public published price for delayed-release dimethyl fumarate versus relevant Multiple Sclerosis disease-modifying therapies available in France in June 2015. Methods The economic model was adapted to the French setting in accordance with the Haute Autorité de Santé guidelines using a model previously developed for NICE. A cohort of Relapsing Remitting Multiple Sclerosis patients was simulated over a 30-year time horizon. Twenty one health states were taken into account: Kurtzke Expanded Disability Status Scale (EDSS) 0–9 for Relapsing Remitting Multiple Sclerosis patients, EDSS 0–9 for Secondary Progressive Multiple Sclerosis patients, and death. Estimates of relative treatment efficacy were determined using a mixed-treatment comparison. Probabilities of events were derived from the dimethyl fumarate pivotal clinical trials and the London Ontario Dataset. Costs and utilities were extracted from the published literature from both the payer and societal perspectives. Univariate and probabilistic sensitivity analyses were performed to assess the robustness of the model results. Results From both perspectives, dimethyl fumarate and interferon beta-1a (IFN beta-1a) 44mcg were the two optimal treatments, as the other treatments (IFN beta-1a 30mcg, IFN beta-1b 250mcg, teriflunomide, glatiramer acetate, fingolimod) were dominated on the efficiency frontier. From the societal perspective, dimethyl fumarate versus IFN beta-1a 44mcg incurred an incremental cost of €3,684 and an incremental quality-adjusted life year (QALY) of 0.281, corresponding to an ICER of €13,110/QALY. Conclusions Despite no reference threshold for France, dimethyl fumarate can be considered as a cost-effective option as it is on the efficiency frontier. PMID:26987055

  13. Societal preferences for standard health insurance coverage in the Netherlands: a cross-sectional study

    PubMed Central

    van den Hout, Wilbert B; de Vries, Marieke; Stiggelbout, Anne M; van den Akker-van Marle, Elske M

    2012-01-01

    Introduction Cost-effectiveness is an important criterion in the decision to cover interventions in health insurance packages. One of the outcome measures, the quality-adjusted life year, has been criticised on its assumptions and implications concerning life expectancy and quality of life. Several studies have been conducted that measured societal preferences concerning healthcare rationing decisions. These studies mainly focused on one attribute. To adjust quality-adjusted life year maximisation in accordance with societal preferences, the relative importance of attributes should be studied. The present study aims to measure the relative importance of age, gender, socioeconomic status, pre-intervention health state, treatment effect, chance of treatment success and number of people in need of the intervention. A secondary objective is to compare the validity of the willingness to pay method with the validity of a relatively new preference elicitation method, best–worst scaling. Methods and analysis A representative sample of 2000 Dutch citizens, over 18 years of age, are recruited to complete a web-based survey containing treatment scenarios. The scenarios present different levels of attributes. Respondents are asked to select one of the four scenarios that they prefer to be covered by the Dutch standard health insurance package and one that they prefer not to be covered. They are also asked to indicate how much they are willing to pay for each treatment scenario. At the end of the survey, respondents are asked to rate every attribute on a 1–10 scale. Two versions of the questionnaire are developed which differ on the framing, that is, treatments can be added to or removed from the insurance package. The data will be analysed by means of sequential conditional logit analysis (best–worst scaling) and analysis of variance (willingness to pay). Ethics and dissemination The protocol is reviewed and approved by the medical ethical committee of the University Medical Center Leiden. PMID:22492390

  14. The healthcare and societal burden associated with influenza in vaccinated and unvaccinated European and Israeli children.

    PubMed

    Ambrose, C S; Antonova, E N

    2014-04-01

    Few data exist regarding the healthcare and societal burden of culture-confirmed influenza illness in European and Israeli children. The current analysis describes this burden in vaccinated and unvaccinated children 2-17 years of age. Healthcare and societal burden outcomes were prospectively collected for culture-confirmed influenza illness in three previous randomized studies: a study of live attenuated influenza vaccine (LAIV) versus placebo in children aged <48 months attending day care (N = 846-973), and studies of LAIV versus inactivated influenza vaccine (IIV) in children aged <72 months with recurrent respiratory infections (N = 1,609) and in children aged 6-17 years with asthma (N = 2,211). The incidence of each endpoint among enrolled subjects and subjects with influenza was determined by treatment group and by country. Among subjects with influenza, 57-91% missed school or day care, 45-90% used non-antibiotic medications, 29-55% of parents missed work, 17-55% used antibiotics, 11-62% had additional provider visits, and 9-20% had acute otitis media. Where evaluated, rates of outcomes were generally similar between countries. Among all children enrolled, LAIV recipients missed 324-902 and 150 fewer days of day care per 1,000 children than those of placebo and IIV recipients, respectively; parents of LAIV recipients missed 197-340 and 76 fewer days of work per 1,000 children than those of placebo and IIV recipients, respectively. Influenza illness in European and Israeli children 2-17 years of age resulted in a considerable absenteeism and healthcare utilization that was similar across the countries studied. These data underscore the potential benefits of annual vaccination of children against influenza. PMID:24091746

  15. Climate Change Impacts and Responses: Societal Indicators for the National Climate Assessment

    NASA Technical Reports Server (NTRS)

    Kenney, Melissa A.; Chen, Robert S.; Maldonado, Julie; Quattrochi, Dale

    2011-01-01

    The Climate Change Impacts and Responses: Societal Indicators for the National Climate Assessment workshop, sponsored by the National Aeronautics and Space Administration (NASA) for the National Climate Assessment (NCA), was held on April 28-29, 2011 at The Madison Hotel in Washington, DC. A group of 56 experts (see list in Appendix B) convened to share their experiences. Participants brought to bear a wide range of disciplinary expertise in the social and natural sciences, sector experience, and knowledge about developing and implementing indicators for a range of purposes. Participants included representatives from federal and state government, non-governmental organizations, tribes, universities, and communities. The purpose of the workshop was to assist the NCA in developing a strategic framework for climate-related physical, ecological, and socioeconomic indicators that can be easily communicated with the U.S. population and that will support monitoring, assessment, prediction, evaluation, and decision-making. The NCA indicators are envisioned as a relatively small number of policy-relevant integrated indicators designed to provide a consistent, objective, and transparent overview of major variations in climate impacts, vulnerabilities, adaptation, and mitigation activities across sectors, regions, and timeframes. The workshop participants were asked to provide input on a number of topics, including: (1) categories of societal indicators for the NCA; (2) alternative approaches to constructing indicators and the better approaches for NCA to consider; (3) specific requirements and criteria for implementing the indicators; and (4) sources of data for and creators of such indicators. Socioeconomic indicators could include demographic, cultural, behavioral, economic, public health, and policy components relevant to impacts, vulnerabilities, and adaptation to climate change as well as both proactive and reactive responses to climate change. Participants provided inputs through in-depth discussion in breakout sessions, plenary sessions on break-out results, and several panels that provided key insights about indicators, lessons learned through experience with developing and implementing indicators, and thoughts on how the NCA could proceed to develop indicators for the NCA.

  16. Societal costs of air pollution-related health hazards: A review of methods and results

    PubMed Central

    Pervin, Tanjima; Gerdtham, Ulf-G; Lyttkens, Carl Hampus

    2008-01-01

    This paper aims to provide a critical and systematic review of the societal costs of air pollution-related ill health (CAP), to explore methodological issues that may be important when assessing or comparing CAP across countries and to suggest ways in which future CAP studies can be made more useful for policy analysis. The methodology includes a systematic search based on the major electronic databases and the websites of a number of major international organizations. Studies are categorized by origin – OECD countries or non-OECD countries – and by publication status. Seventeen studies are included, eight from OECD countries and nine from non-OECD countries. A number of studies based on the ExternE methodology and the USA studies conducted by the Institute of Transportation are also summarized and discussed separately. The present review shows that considerable societal costs are attributable to air pollution-related health hazards. Nevertheless, given the variations in the methodologies used to calculate the estimated costs (e.g. cost estimation methods and cost components included), and inter-country differences in demographic composition and health care systems, it is difficult to compare CAP estimates across studies and countries. To increase awareness concerning the air pollution-related burden of disease, and to build links to health policy analyses, future research efforts should be directed towards theoretically sound and comprehensive CAP estimates with use of rich data. In particular, a more explicit approach should be followed to deal with uncertainties in the estimations. Along with monetary estimates, future research should also report all physical impacts and source-specific cost estimates, and should attempt to estimate 'avoidable cost' using alternative counterfactual scenarios. PMID:18786247

  17. Societal-level Risk Factors Associated with Pediatric Hearing Loss: A Systematic Review

    PubMed Central

    Vasconcellos, Adam P.; Colello, Stephanie; Kyle, Meghann E.; Shin, Jennifer J.

    2015-01-01

    Objective To determine if the current body of evidence describes specific threshold values of concern for modifiable societal-level risk factors for pediatric hearing loss, with the overarching goal of providing actionable guidance for the prevention and screening of audiological deficits in children. Data Sources Three related systematic reviews were performed. Computerized PubMed, Embase, and Cochrane Library searches were performed from inception through October 2013 and were supplemented with manual searches. Review Methods Inclusion/exclusion criteria were designed to determine specific threshold values of societal-level risk factors on hearing loss in the pediatric population. Searches and data extraction were performed by independent reviewers. Results There were 20 criterion-meeting studies with 29,128 participants. Infants less than 2 standard deviations below standardized weight, length, or body mass index were at increased risk. Specific nutritional deficiencies related to iodine and thiamine may also increase risk, although data are limited and threshold values of concern have not been quantified. Blood lead levels above 10 ?g/dL were significantly associated with pediatric sensorineural loss, and mixed findings were noted for other heavy metals. Hearing loss was also more prevalent among children of socioeconomically disadvantaged families, as measured by a poverty income ratio less than 0.3 to 1, higher deprivation category status, and head of household employment as a manual laborer. Conclusions Increasing our understanding of specific thresholds of risk associated with causative factors forms the foundation for preventive and targeted screening programs as well as future research endeavors. PMID:24671458

  18. An Improved Inertial Frame Alignment Algorithm Based on Horizontal Alignment Information for Marine SINS

    PubMed Central

    Che, Yanting; Wang, Qiuying; Gao, Wei; Yu, Fei

    2015-01-01

    In this paper, an improved inertial frame alignment algorithm for a marine SINS under mooring conditions is proposed, which significantly improves accuracy. Since the horizontal alignment is easy to complete, and a characteristic of gravity is that its component in the horizontal plane is zero, we use a clever method to improve the conventional inertial alignment algorithm. Firstly, a large misalignment angle model and a dimensionality reduction Gauss-Hermite filter are employed to establish the fine horizontal reference frame. Based on this, the projection of the gravity in the body inertial coordinate frame can be calculated easily. Then, the initial alignment algorithm is accomplished through an inertial frame alignment algorithm. The simulation and experiment results show that the improved initial alignment algorithm performs better than the conventional inertial alignment algorithm, and meets the accuracy requirements of a medium-accuracy marine SINS. PMID:26445048

  19. Pin-Align: a new dynamic programming approach to align protein-protein interaction networks.

    PubMed

    Amir-Ghiasvand, Farid; Nowzari-Dalini, Abbas; Momenzadeh, Vida

    2014-01-01

    To date, few tools for aligning protein-protein interaction networks have been suggested. These tools typically find conserved interaction patterns using various local or global alignment algorithms. However, the improvement of the speed, scalability, simplification, and accuracy of network alignment tools is still the target of new researches. In this paper, we introduce Pin-Align, a new tool for local alignment of protein-protein interaction networks. Pin-Align accuracy is tested on protein interaction networks from IntAct, DIP, and the Stanford Network Database and the results are compared with other well-known algorithms. It is shown that Pin-Align has higher sensitivity and specificity in terms of KEGG Ortholog groups. PMID:25435900

  20. An Improved Inertial Frame Alignment Algorithm Based on Horizontal Alignment Information for Marine SINS.

    PubMed

    Che, Yanting; Wang, Qiuying; Gao, Wei; Yu, Fei

    2015-01-01

    In this paper, an improved inertial frame alignment algorithm for a marine SINS under mooring conditions is proposed, which significantly improves accuracy. Since the horizontal alignment is easy to complete, and a characteristic of gravity is that its component in the horizontal plane is zero, we use a clever method to improve the conventional inertial alignment algorithm. Firstly, a large misalignment angle model and a dimensionality reduction Gauss-Hermite filter are employed to establish the fine horizontal reference frame. Based on this, the projection of the gravity in the body inertial coordinate frame can be calculated easily. Then, the initial alignment algorithm is accomplished through an inertial frame alignment algorithm. The simulation and experiment results show that the improved initial alignment algorithm performs better than the conventional inertial alignment algorithm, and meets the accuracy requirements of a medium-accuracy marine SINS. PMID:26445048

  1. Phylo: A Citizen Science Approach for Improving Multiple Sequence Alignment

    PubMed Central

    Kam, Alfred; Kwak, Daniel; Leung, Clarence; Wu, Chu; Zarour, Eleyine; Sarmenta, Luis; Blanchette, Mathieu; Waldispühl, Jérôme

    2012-01-01

    Background Comparative genomics, or the study of the relationships of genome structure and function across different species, offers a powerful tool for studying evolution, annotating genomes, and understanding the causes of various genetic disorders. However, aligning multiple sequences of DNA, an essential intermediate step for most types of analyses, is a difficult computational task. In parallel, citizen science, an approach that takes advantage of the fact that the human brain is exquisitely tuned to solving specific types of problems, is becoming increasingly popular. There, instances of hard computational problems are dispatched to a crowd of non-expert human game players and solutions are sent back to a central server. Methodology/Principal Findings We introduce Phylo, a human-based computing framework applying “crowd sourcing” techniques to solve the Multiple Sequence Alignment (MSA) problem. The key idea of Phylo is to convert the MSA problem into a casual game that can be played by ordinary web users with a minimal prior knowledge of the biological context. We applied this strategy to improve the alignment of the promoters of disease-related genes from up to 44 vertebrate species. Since the launch in November 2010, we received more than 350,000 solutions submitted from more than 12,000 registered users. Our results show that solutions submitted contributed to improving the accuracy of up to 70% of the alignment blocks considered. Conclusions/Significance We demonstrate that, combined with classical algorithms, crowd computing techniques can be successfully used to help improving the accuracy of MSA. More importantly, we show that an NP-hard computational problem can be embedded in casual game that can be easily played by people without significant scientific training. This suggests that citizen science approaches can be used to exploit the billions of “human-brain peta-flops” of computation that are spent every day playing games. Phylo is available at: http://phylo.cs.mcgill.ca. PMID:22412834

  2. Proper alignment of the microscope.

    PubMed

    Rottenfusser, Rudi

    2013-01-01

    The light microscope is merely the first element of an imaging system in a research facility. Such a system may include high-speed and/or high-resolution image acquisition capabilities, confocal technologies, and super-resolution methods of various types. Yet more than ever, the proverb "garbage in-garbage out" remains a fact. Image manipulations may be used to conceal a suboptimal microscope setup, but an artifact-free image can only be obtained when the microscope is optimally aligned, both mechanically and optically. Something else is often overlooked in the quest to get the best image out of the microscope: Proper sample preparation! The microscope optics can only do its job when its design criteria are matched to the specimen or vice versa. The specimen itself, the mounting medium, the cover slip, and the type of immersion medium (if applicable) are all part of the total optical makeup. To get the best results out of a microscope, understanding the functions of all of its variable components is important. Only then one knows how to optimize these components for the intended application. Different approaches might be chosen to discuss all of the microscope's components. We decided to follow the light path which starts with the light source and ends at the camera or the eyepieces. To add more transparency to this sequence, the section up to the microscope stage was called the "Illuminating Section", to be followed by the "Imaging Section" which starts with the microscope objective. After understanding the various components, we can start "working with the microscope." To get the best resolution and contrast from the microscope, the practice of "Koehler Illumination" should be understood and followed by every serious microscopist. Step-by-step instructions as well as illustrations of the beam path in an upright and inverted microscope are included in this chapter. A few practical considerations are listed in Section 3. PMID:23931502

  3. Sparse alignment for robust tensor learning.

    PubMed

    Lai, Zhihui; Wong, Wai Keung; Xu, Yong; Zhao, Cairong; Sun, Mingming

    2014-10-01

    Multilinear/tensor extensions of manifold learning based algorithms have been widely used in computer vision and pattern recognition. This paper first provides a systematic analysis of the multilinear extensions for the most popular methods by using alignment techniques, thereby obtaining a general tensor alignment framework. From this framework, it is easy to show that the manifold learning based tensor learning methods are intrinsically different from the alignment techniques. Based on the alignment framework, a robust tensor learning method called sparse tensor alignment (STA) is then proposed for unsupervised tensor feature extraction. Different from the existing tensor learning methods, L1- and L2-norms are introduced to enhance the robustness in the alignment step of the STA. The advantage of the proposed technique is that the difficulty in selecting the size of the local neighborhood can be avoided in the manifold learning based tensor feature extraction algorithms. Although STA is an unsupervised learning method, the sparsity encodes the discriminative information in the alignment step and provides the robustness of STA. Extensive experiments on the well-known image databases as well as action and hand gesture databases by encoding object images as tensors demonstrate that the proposed STA algorithm gives the most competitive performance when compared with the tensor-based unsupervised learning methods. PMID:25291733

  4. Database searching by flexible protein structure alignment

    PubMed Central

    Ye, Yuzhen; Godzik, Adam

    2004-01-01

    We have recently developed a flexible protein structure alignment program (FATCAT) that identifies structural similarity, at the same time accounting for flexibility of protein structures. One of the most important applications of a structure alignment method is to aid in functional annotations by identifying similar structures in large structural databases. However, none of the flexible structure alignment methods were applied in this task because of a lack of significance estimation of flexible alignments. In this paper, we developed an estimate of the statistical significance of FATCAT alignment score, allowing us to use it as a database-searching tool. The results reported here show that (1) the distribution of the similarity score of FATCAT alignment between two unrelated protein structures follows the extreme value distribution (EVD), adding one more example to the current collection of EVDs of sequence and structure similarities; (2) introducing flexibility into structure comparison only slightly influences the sensitivity and specificity of identifying similar structures; and (3) the overall performance of FATCAT as a database searching tool is comparable to that of the widely used rigid-body structure comparison programs DALI and CE. Two examples illustrating the advantages of using flexible structure alignments in database searching are also presented. The conformational flexibilities that were detected in the first example may be involved with substrate specificity, and the conformational flexibilities detected in the second example may reflect the evolution of structures by block building. PMID:15215527

  5. Improved approximation algorithms for tree alignment

    SciTech Connect

    Wang, Lusheng; Gusfield, D.

    1996-12-31

    Multiple sequence alignment is a task at the heart of much of current computational biology. Several different objective functions have been proposed to formalize the task of multiple sequence alignment, but efficient algorithms are lacking in each case. Thus multiple sequence alignment is one of the most critical, essentially unsolved problems in computational biology. In this paper the authors consider one of the more compelling objective functions for multiple sequence alignment, formalized as the tree alignment problems. Previously, a factor-of-two approximation method was developed for the tree alignment, which ran in cubic time (as a function of the number of fixed length strings to be aligned), along with a polynomial time approximation scheme (PTAS) for the problem. However, the PTAS had a running time which made it impractical to reduce the error bound much below two for small size biological sequences (100 characters long). In this paper the authors first develop a factor-of-two approximation algorithm which runs in quadratic time, and then use it to develop a PTAS which has a smaller guaranteed error bound and a vastly improved worst case running time compared to other schemes. With the new approximation scheme, it is now practical to guarantee an error bound of 1.583 for strings of lengths 200 characters or less. 15 refs., 5 figs., 1 tab.

  6. Alignment Cube with One Diffractive Face

    NASA Technical Reports Server (NTRS)

    Ohl, Raymond G.; Sampler, Henry P.; Strojny, Carl R.; Hagopian, John G.; McMann, Joseph C.

    2006-01-01

    An enhanced alignment cube has been invented for use in a confined setting (e.g., a cryogenic chamber) in which optical access may be limited to a single line of sight. Whereas traditional alignment-cube practice entails the use of two theodolites aimed along two lines of sight, the enhanced alignment cube yields complete alignment information through use of a single theodolite aimed along a single line of sight. Typically, an alignment cube is placed in contact with a datum surface or other reference feature on a scientific instrument during assembly or testing of the instrument. The alignment cube is then used in measuring a small angular deviation of the feature from a precise required orientation. Commonly, the deviation is expressed in terms of rotations (Rx,Ry,Rz) of the cube about the corresponding Cartesian axes (x,y,z). In traditional practice, in order to measure all three rotations, it is necessary to use two theodolites aimed at two orthogonal faces of the alignment cube, as shown in the upper part of the figure. To be able to perform such a measurement, one needs optical access to these two faces. In the case of an alignment cube inside a cryogenic chamber or other enclosed space, the optical-access requirement translates to a requirement for two windows located along the corresponding two orthogonal lines of sight into the chamber. In a typical application, it is difficult or impossible to provide two windows. The present enhanced version of the alignment cube makes it possible to measure all three rotations by use of a single line of sight, thereby obviating a second window.

  7. Engineering of aligned skeletal muscle by micropatterning

    PubMed Central

    Huang, Ngan F; Lee, Randall J; Li, Song

    2010-01-01

    Tissue engineered skeletal muscle has tremendous potential for the treatment of muscular injury or muscular dysfunction. However, in vitro methods to generate skeletal muscle with physiologically aligned myofiber structure remains limited. To develop a robust in vitro model that resembles the physiologically aligned structure of muscle fibers, we fabricated micropatterned polymer membranes of poly(dimethylsiloxane) (PDMS) with parallel microgrooves, and then examined the effect of micropatterning on myoblast cellular organization and the cell fusion process. In comparison to the myoblasts on non-patterned PDMS films, myoblasts on micropatterned PDMS films had well-organized F-actin assembly in close proximity to the direction of microgrooves, along with enhanced levels of myotube formation at early time points. The increase of cell cycle regulator p21WAF/Cip1 and the organized interactions of N-cadherin in myoblasts on micropatterned surfaces may contribute to the enhanced formation of myotubes. Similar results of cellular alignment was observed when myoblasts were cultured on microfluidically patterned poly(2-hydroxyethyl methacrylate) (pHEMA) microgrooves, and the micropatterns were found to detach from the Petri dish over time. To apply this technology for generating aligned tissue-like muscle constructs, we developed a methodology to transfer the aligned myotubes to biodegradable collagen gels. Histological analysis revealed the persistence of aligned cellular organization in the collagen gels. Together, these results demonstrate that micropatterned PDMS or pHEMA can promote cell alignment and fusion along the direction of the microgrooves, and this platform can be utilized to transfer aligned myotubes on biodegradable hydrogels. This study highlights the importance of spatial cues in creating aligned skeletal muscle for tissue engineering and muscular regeneration applications. PMID:20182581

  8. Children's Reasoning about Spatial Relational Similarity: The Effect of Alignment and Relational Complexity

    ERIC Educational Resources Information Center

    Hribar, Alenka; Haun, Daniel B. M.; Call, Josep

    2012-01-01

    We investigated 4- and 5-year-old children's mapping strategies in a spatial task. Children were required to find a picture in an array of three identical cups after observing another picture being hidden in another array of three cups. The arrays were either aligned one behind the other in two rows or placed side by side forming one line.…

  9. Out of Focus: Aligning a Donor's Vision with Institutional Needs Is a Tricky Balancing Act

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2011-01-01

    For years, development officers have cultivated prospective donors by listening to their deepest desires. Now, development officers' work increasingly involves devising a strategy for aligning the donor's desires with the mission, goals, and needs of their institution. It is possible, even amid signs of changing donor agendas and attitudes, but it…

  10. Redesigning and Aligning Assessment and Evaluation for a Federally Funded Math and Science Teacher Educational Program

    ERIC Educational Resources Information Center

    Hardre, Patricia L.; Slater, Janis; Nanny, Mark

    2010-01-01

    This paper examines the redesign of evaluation components for a teacher professional development project funded by the National Science Foundation. It focuses on aligning evaluation instrumentation and strategies with program goals, research goals and program evaluation best practices. The study identifies weaknesses in the original (year 1)…

  11. Self-aligning biaxial load frame

    DOEpatents

    Ward, M.B.; Epstein, J.S.; Lloyd, W.R.

    1994-01-18

    An self-aligning biaxial loading apparatus for use in testing the strength of specimens while maintaining a constant specimen centroid during the loading operation. The self-aligning biaxial loading apparatus consists of a load frame and two load assemblies for imparting two independent perpendicular forces upon a test specimen. The constant test specimen centroid is maintained by providing elements for linear motion of the load frame relative to a fixed cross head, and by alignment and linear motion elements of one load assembly relative to the load frame. 3 figures.

  12. Self-aligning biaxial load frame

    DOEpatents

    Ward, Michael B.; Epstein, Jonathan S.; Lloyd, W. Randolph

    1994-01-01

    An self-aligning biaxial loading apparatus for use in testing the strength of specimens while maintaining a constant specimen centroid during the loading operation. The self-aligning biaxial loading apparatus consists of a load frame and two load assemblies for imparting two independent perpendicular forces upon a test specimen. The constant test specimen centroid is maintained by providing elements for linear motion of the load frame relative to a fixed crosshead, and by alignment and linear motion elements of one load assembly relative to the load frame.

  13. Alignment and stability of future machines

    SciTech Connect

    Shiltsev, V.D.

    1996-06-01

    Leading accelerator laboratories mount serious efforts in alignment and vibration studies concerning stability of future accelerator facilities such as photon and meson factories, future linear colliders (LCs), and hadron supercolliders (HCs). Some 200 publications covered the topic since late 80s, following pioneering works of G.E. Fischer. Four International workshops on accelerator alignment were held since 1989 at SLAC, DESY, CERN and KEK. The SSCL hosted the workshop on vibration control and dynamic alignment (1992). This article briefly covers some present achievements and issues in the field. We discuss major effects and tolerances for the future accelerators, results of measurements up-to-date, correction techniques and make some conclusions.

  14. HETDEX: VIRUS Spectrographs Assembly and Alignment

    NASA Astrophysics Data System (ADS)

    Prochaska, Travis; Marshall, J. L.; DePoy, D. L.; Boster, E.; Meador, W.; Allen, R.; Hill, G. J.; HETDEX Collaboration

    2012-01-01

    We describe the assembly and optical alignment process used to construct the Visual Integral-Field Replicable Unit Spectrograph (VIRUS) instrument. VIRUS is a set of 150+ optical spectrographs designed to support observations for the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX). To meet the accuracy, interchangeability, time and cost constraints, a production line will be set up to construct and test modular subassemblies in parallel. To facilitate the VIRUS production, fixtures and adjustment mechanisms have been designed to aid in assembly and alignment. This poster describes the details and operations of the camera mirror, collimator mirror and grating adjustment mechanisms, as well as the fold flat mirror alignment fixture.

  15. Alignment of chirped-pulse compressor

    SciTech Connect

    Yakovlev, I V

    2012-11-30

    An original method of alignment of grating compressors for ultrahigh-power CPA laser systems is proposed. The use of this method for adjustment of the grating compressor of a PEARL subpetawatt laser complex made it possible to align the diffraction gratings with a second accuracy in all three angular degrees of freedom, including alignment of the grooves, and to adjust the angles of beam incidence on the grating with a high accuracy. A simple method for measuring the difference in the groove densities of gratings with accuracy better than 0.005 lines mm{sup -1} is proposed and tested. (control of laser radiation parameters)

  16. Line of sight methods of alignment

    NASA Astrophysics Data System (ADS)

    Parks, Robert E.

    2008-08-01

    Three methods of line of sight alignment are compared and contrasted for ease of use, accuracy of alignment and cost of equipment and fixtures. The three methods are the classical use of an alignment telescope, use of a laser beam to establish an axis, something impossible until the invention of the CW laser, and an autostigmatic microscope used in conjunction with mechanical means to establish an axis or points in space. While the method of choice is usually a pragmatic one of using the equipment at hand, this paper will demonstrate the flexibility of the autostigmatic microscope approach.

  17. Integration, alignment, testing, and field support of a multisensor system

    NASA Astrophysics Data System (ADS)

    Hall, Stephen L.

    2004-07-01

    The phase of the development engineering life cycle in which the greatest risk traditionally emerges is that of integration and test, culminating in final acceptance. Attention is often paid to integration and test aspects too late to influence the earlier phases of the life cycle, where the seeds are sown for success or failure. This paper presents a strategy that actively addresses integration aspects as early as possible, to mitigate these risks, where possible, well ahead of commencement of the implementation of the integration phase. A multi-sensor Naval fire-control system is taken as an example, and this is used to focus on the essential elements of the strategy for the successful integration of Radar and EO sensors. These include: design for integration, a robust and accurate method of aligning the sensors, and test cases which reflect the in service usage of the system. The methods of alignment both in the dockyard and at sea are described, together with a threads analysis approach to determining system functionality, user operational requirements and hence determining system functional test coverage. Finally conclusions are drawn, comparing the classical approach to the one described in the paper, showing the benefits to de-risking the engineering life cycle and achieving an in-service system which has the functionality and performance the user is expecting.

  18. Global multiple protein-protein interaction network alignment by combining pairwise network alignments

    PubMed Central

    2015-01-01

    Background A wealth of protein interaction data has become available in recent years, creating an urgent need for powerful analysis techniques. In this context, the problem of finding biologically meaningful correspondences between different protein-protein interaction networks (PPIN) is of particular interest. The PPIN of a species can be compared with that of other species through the process of PPIN alignment. Such an alignment can provide insight into basic problems like species evolution and network component function determination, as well as translational problems such as target identification and elucidation of mechanisms of disease spread. Furthermore, multiple PPINs can be aligned simultaneously, expanding the analytical implications of the result. While there are several pairwise network alignment algorithms, few methods are capable of multiple network alignment. Results We propose SMAL, a MNA algorithm based on the philosophy of scaffold-based alignment. SMAL is capable of converting results from any global pairwise alignment algorithms into a MNA in linear time. Using this method, we have built multiple network alignments based on combining pairwise alignments from a number of publicly available (pairwise) network aligners. We tested SMAL using PPINs of eight species derived from the IntAct repository and employed a number of measures to evaluate performance. Additionally, as part of our experimental investigations, we compared the effectiveness of SMAL while aligning up to eight input PPINs, and examined the effect of scaffold network choice on the alignments. Conclusions A key advantage of SMAL lies in its ability to create MNAs through the use of pairwise network aligners for which native MNA implementations do not exist. Experiments indicate that the performance of SMAL was comparable to that of the native MNA implementation of established methods such as IsoRankN and SMETANA. However, in terms of computational time, SMAL was significantly faster. SMAL was also able to retain many important characteristics of the native pairwise alignments, such as the number of aligned nodes and edges, as well as the functional and homologene similarity of aligned nodes. The speed, flexibility and the ability to retain prior correspondences as new networks are aligned, makes SMAL a compelling choice for alignment of multiple large networks. PMID:26423128

  19. Subjective Well-Being, Societal Condition and Social Policy--The Case Study of a Rich Chinese Society

    ERIC Educational Resources Information Center

    Wong, Chack Kie; Wong, Ka Ying; Mok, Bong Ho

    2006-01-01

    The article looks at whether or not social policy and other societal-condition variables contribute to the subjective well-being of life satisfaction. It firstly argues that social policy needs to pay more attention to the study of subjective well-being. Then, it reviews the literature and finds that people in rich societies generally have higher…

  20. Perceptions of the News Media's Societal Roles: How the Views of U.K. Journalism Students Changed during Their Education

    ERIC Educational Resources Information Center

    Hanna, Mark; Sanders, Karen

    2012-01-01

    A longitudinal study of U.K. journalism undergraduates records how their attitudes on societal roles of the news media changed during university education. Students became more likely to endorse an adversarial approach toward public officials and businesses as extremely important. Yet students did not support these roles as strongly as an older…