Co-expression of HoxA9 and bcr-abl genes in chronic myeloid leukemia.

PubMed

Tedeschi, Fabián A; Cardozo, Maria A; Valentini, Rosanna; Zalazar, Fabián E

2010-05-01

We have analyzed the co-expression of the bcr-abl and HoxA9 genes in the follow-up of patients with chronic myeloid leukemia (CML). In the present work we measured the HoxA9 and bcr-abl gene expression in sequential samples. In all patients, bcr-abl and HoxA9 were expressed at detectable levels in every sample. When the results were expressed in relation to abl, two different situations were found: (a) patients clinically stable at second sampling, with low relative risk at diagnosis (low Sokal's score), did not show significant differences in both bcr-abl and HoxA9 levels in the sequential samples analyzed, and (b) patients with poor prognosis (showing intermediate or high Sokal's score at diagnosis) had increased expression of bcr-abl as well as HoxA9 genes (p < 0.05). Since HoxA9 gene expression remains at relatively constant levels throughout adult life, our results could reflect actual changes in the expression rate of this gene associated with bcr-abl during the progression of CML.

Clustering, Dimensionality Reduction, and Side Information

DTIC Science & Technology

2006-01-01

Steinhaus in 1955 [243], Lloyd in 1957 [174], and MacQueen in 1967 [178]. The ISODATA algorithm by Ball and Hall in 1965 [8] can be regarded as an adaptive...1958. [242] R.R. Sokal and P.H.A. Sneath. Principles of Numerical Taxonomy. San Francisco, W. H. Freeman, 1963. [243] H. Steinhaus . Sur la division

Shared meal between STS-84 and Mir 23 crews

NASA Image and Video Library

1997-06-23

STS084-360-010 (15-24 May 1997) --- On Russia's Mir Space Station's Base Block, Mir-23 flight engineer Aleksandr I. Lazutkin greets his STS-84 counterpart, Carlos I. Noriega, soon after hatch opening. Partially visible at left is Vasili V. Tsibliyev, Mir-23 commander.

Soils regulate and mitigate climate change

USDA-ARS?s Scientific Manuscript database

Background/Question/Methods: The interaction of soil science and ecology can be traced back to the origins of soil science as an independent discipline within the natural sciences. Vasili Dokuchaev, the founder of modern soil science, identified five soil forming factors: parent material, climate, o...

Environmental Gradient Analysis, Ordination, and Classification in Environmental Impact Assessments.

DTIC Science & Technology

1987-09-01

agglomerative clustering algorithms for mainframe computers: (1) the unweighted pair-group method that V uses arithmetic averages ( UPGMA ), (2) the...hierarchical agglomerative unweighted pair-group method using arithmetic averages ( UPGMA ), which is also called average linkage clustering. This method was...dendrograms produced by weighted clustering (93). Sneath and Sokal (94), Romesburg (84), and Seber• (90) also strongly recommend the UPGMA . A dendrogram

Very Large Scale Distributed Information Processing Systems

DTIC Science & Technology

1991-09-27

USENIX Conference Proceedings, pp. 31-43. USENIX, February 1988. [KLA90] Michael L. Kazar, Bruce W. Leverett, Owen T. Anderson, Vasilis Apos- tolides, Beth...will be selected if cost is the curlcron Iorsleettin- IfFigure 2 R DistribUted Database lSgtam and its we combin the abolve two pit , n r-itcrr

To Megali Idea - Dead or Alive? The Domestic Determinants of Greek Foreign Policy

DTIC Science & Technology

1994-03-01

protecting powers were involved in war, with France and England pitted against Russia. This brought upon the Greek leadership the wrath of the Allies, France...Building 684 Bachelor Officer Quarters NETC Newport, RI 02841 6. Vasilis Fotopoulos 1227 Leahy Road Monterey, CA 93940 7. Dr. Paul Stockton, Code 38 Naval Postgraduate School Monterey, CA 93943-5002 63

Values Education in the Soviet State: The Lasting Contribution of V. A. Sukhomlinsky

ERIC Educational Resources Information Center

Cockerill, Alan

2011-01-01

Vasily Sukhomlinsky (1918-1970) was arguably the most influential Soviet educator of the post-war period. He was a practising teacher, and from 1947 to 1970 was principal of a school in the Ukrainian village of Pavlysh. One of Sukhomlinsky's primary concerns was to inculcate in his students the values of compassion and service, combined with…

Compilation of 1986 Annual Reports of the Navy ELF (Extremely Low Frequency) Communications System Ecological Monitoring Program. Volume 3. TABS H-J.

DTIC Science & Technology

1987-07-01

yearly trends, and the effect of population size and abiotic factors on growth will be completed when the 1984-1986 scales are completed. Fish condition...settling of suspended particles on substrates in its absence. The pumps were powered by a heavy duty marine battery which had to be exchanged and...computer using procedures available in SPSS (Hull and Nie 1981) and programs available in the BIOM statistical package (Rohlf). Sokal and Rohlf (1981

TEM verification of the <111>-type 4-arm multi-junction in [001]-Mo single crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsiung, L

2005-03-14

To investigate and verify the formation of <111>-type 4-arm multi-junction by the dislocation reaction of 1/2[111] [b1] + 1/2[{bar 1}1{bar 1}] [b2] + 1/2[{bar 1}{bar 1}1] [b3] = 1/2[{bar 1}11] [b4], which has recently been discovered through computer simulations conducted by Vasily Bulatov and his colleagues.

STS-84 and Mir 23 crewmembers exchange gifts during welcome ceremony after docking

NASA Image and Video Library

1997-05-17

STS084-376-005 (15-24 May 1997) --- Onboard the Core Module of Russia's Mir Space Station, the American Space Shuttle commander exchanges gifts with the Mir-23 crew. Astronaut Charles J. Precourt has just handed two picture albums, documenting several months of interface between the Americans and Russians, to cosmonauts Aleksandr I. Lazutkin (left), flight engineer; and Vasili Tsibliyev, commander.

An Analysis of Alternatives to Verbal FM Radio Tactical Command and Control Communications

DTIC Science & Technology

1975-06-06

specialist’s ,, , nwarted by these means even more reliablv than by conventional weapons.16 renaoiy an enemy attack can be th1 Marshal Vasili ...Mort Pit Squad(4) FDC F0(3) LDR FAC Bn LN0(2) Conmel Cff Survl Sec Sgt Commo Pit Gnd Survl Sec(6) Spt Pit Co Maint Sec AVLB Sec Med Sec Bn

Reconnaissance-Pul - Seeking the Path of Least Resistance

DTIC Science & Technology

1990-12-15

Carl von Clausewitz, the great eighteenth century military theorist, also professed pitting friendly strength against enemy weakness. Addressing "the...izortance of reconnaissance, its relation to intelligence, and the advantage of pitting friendly strength against enemy weaknesses. The Soviets use a...64. Ibid. 65. Vasily Gerasimovich Reznichenko, "Taktika" (Tactics), translated by Foreign Broadcast Information Service (Moscow, 1988):p.55. 66

One Is Not Born a Mathematician: In Conversation with Vasily Davydov

ERIC Educational Resources Information Center

Fellus, Osnat; Biton, Yaniv

2017-01-01

That mathematics education has been one of the central concerns of educational systems worldwide is no secret. It is also an established consensus that as far back as eighty years ago, Russian psychologists such as Vygotsky, Luria, Meshcheryakov, and Davydov have pioneered work that contributed to the understanding of teaching and learning and…

STS-102 / Expedition 1 Crew Return Ceremony at Ellington Field.

NASA Image and Video Library

2001-03-22

JSC2001-E-08325 (22 March 2001) --- Some of the participants of the Expedition One and STS-102 crew return ceremony applaud one of the speakers. Pictured from the left are cosmonaut Vasily Tsibliev, Deputy Director of the Gagarin Cosmonaut Training Center in Star City; cosmonaut Sergei K. Krikalev, Expedition One flight engineer; astronaut William M. (Bill) Shepherd, mission commander; and Yuri P. Gidzenko, Soyuz commander.

The Tank-Attack Helicopter in the European Mid-Intensity Conflict Environment: An Operational Effectiveness Analysis of Competitiveness/ Compatibility

DTIC Science & Technology

1975-06-06

that the warp and woof of the whole cloth will not become discernible until the attack helicopter Is pitted against the tank In actual combat. The...This authoritative book on Soviet military thinking, a product of fifteen leading Soviet military theoreticians headed by Marshal Vasily ...the principal armor-defeating weapons systems ...Most people think in terms of two attack helicopters pitted against an enemy target, perhaps with

Voxel-Wise Time-Series Analysis of Quantitative MRI in Relapsing-Remitting MS: Dynamic Imaging Metrics of Disease Activity Including Pre-Lesional Changes

DTIC Science & Technology

2015-12-01

other parameters match the previous simulation. A third simulation was performed to evaluate the effect of gradient and RF spoiling on the accuracy of...this increase also offers an opportunity to increase the length of the spoiler gradient and improve the accuracy of FA quanti - fication (27). To...Relaxation Pouria Mossahebi,1 Vasily L. Yarnykh,2 and Alexey Samsonov3* Purpose: Cross-relaxation imaging (CRI) is a family of quanti - tative

Various candid views of STS-84 crew after hatch opening

NASA Image and Video Library

1997-05-17

STS084-379-034 (15-24 May 1997) --- Two mission commanders greet and shake hands moments after hatch-opening on docking day, of the Space Shuttle Atlantis and Russia's Mir Space Station. Charles J. Precourt (left), STS-84 commander, and Vasili V. Tsibliyev, Mir-23 commander, along with their respective flight crews went on to spend several days sharing joint activities in Earth-orbit. This is the sixth Atlantis/Mir docking mission.

Generation of Space Debris from Explosion of Spacecrafts’ Fuel Tanks

DTIC Science & Technology

1994-01-01

parui a (2.21):11i",tta pit of jiibl 21 ; n&’(-23)A ineectionl ’On-.,Ar bola (2.191),point 411-ouepnstoti on D id (b~ior time eain le co~didi~-higli...4.4). (4,5) (1111 be vasily solved itow. At first we find: A10 (4.9) and then according m (1.-4) all VjY van bi- (1vt(’rmlne(. 4 Notice that if we

Repressive States and Insurgencies: Implications for Future Campaigns

DTIC Science & Technology

2006-03-12

dissatisfied with the legitimacy of their government who sought to overthrow the ruling power by force. In contrast, “liberation insurgencies” pit insurgents...nuclear war. The history of the fighting behind the German lines, pitting various German security divisions, commands, and leaders against Soviet...Russian revolution was to Vasili Bliukher, who received the Order of the Red Banner for leading his 6,000 man ‘Urals Partisan Army’ on a 900-mile raid

Archeointensities in Greece during the Neolithic period: New insights into material selection and secular variation curve

NASA Astrophysics Data System (ADS)

Fanjat, G.; Aidona, E.; Kondopoulou, D.; Camps, P.; Rathossi, C.; Poidras, T.

2013-02-01

Numerous archeomagnetic studies have provided high quality data for both the direction and the intensity of the geomagnetic field, essentially in Europe for the last 10 millennia. In particular, Greece supplies a lot of archeological materials due to its impressive cultural heritage and volcanic activity, so that numerous data have been obtained from burnt clays or historical lava flows. The most recent Greek secular variation curves are available for the last 8 millennia for the intensity and the last 6 millennia for the direction. Nevertheless, the coverage still presents several gaps for periods older than 2500 BC. In an effort to complete the Greek curve and extend it to older times, we present the archeointensity results from three Neolithic settlements in Northern Greece. The samples are of two different natures: burnt structures from Avgi (5250 ± 150 BC) and Vasili (4800 ± 200 BC), as well as ceramics from Dikili Tash (4830 ± 80 BC) and Vasili (4750 ± 250 BC). The samples have been subjected to standard rock magnetic analyses in order to estimate the thermal stability and the domain state of the magnetic carriers before archeointensity measurements. Surprisingly, very few ceramic samples provided reliable archeointensities whereas samples from burnt structures presented a very good success rate. Complementary studies showed that a detailed examination of the matrix color, following archeological information and classification standards can be a decisive test for pre-selection of sherds. In spite of these unsuccessful measurements from ceramics, we obtained an intensity value of 73.5 ± 1.1 μT for Dikili Tash, a higher value than the other data obtained in the same area, during the same period. However we do not have evidences for a technical artefact during the experiment. The burnt structures yielded two reliable archeointensities of 36.1 ± 1.8 μT and 46.6 ± 3.4 μT for Avgi and Vasili, respectively. Finally, we achieved a new archeomagnetic dating

STS-106 ISS Overview Briefing

NASA Technical Reports Server (NTRS)

2000-01-01

Dwayne Brown, NASA Public Affairs, introduces Bob Cabana of NASA, Mikhail Sinelshikov of PKA, Vasily Tsibliev of GCTC, Steve Mozes of CSA, Ian Pryke of ESA, and Masaaki Komatsu of NASDA. Each man gives an overview of the status of the International Space Station (ISS), including details on the current configuration, future missions and what they will bring to the ISS, and each space agency's contribution to the ISS. They then answer questions from the press.

STS-102 / Expedition 1 Crew Return Ceremony at Ellington Field.

NASA Image and Video Library

2001-03-22

JSC2001-E-08317 (22 March 2001) --- Members of the Expedition One crew await opportunities to individually address a crowd gathered at Ellington Field to honor their return to Houston. return. Pictured from the left are cosmonaut Vasily Tsibliev, Deputy Director of the Gagarin Cosmonaut Training Center in Star City; cosmonaut Sergei K. Krikalev, Expedition One flight engineer; astronaut William M. (Bill) Shepherd, mission commander; and Yuri P. Gidzenko, Soyuz commander; along with Joseph Rothenberg, NASA Associate Administrator for Space Flight.

An underdiscussed aspect of chomsky (1959).

PubMed

Adelman, Barry Eshkol

2007-01-01

Chomsky's (1959) review of Skinner's (1957)Verbal Behavior has been influential and attributed with a role in the cognitive revolution. However, while counter reviews from within behavior analysis have noted that Chomsky misunderstood the subject matter, certain aspects of his scholarship have been underdiscussed. This includes several instances where Chomsky misquotes Skinner or takes his quotes out of context. Similar to the findings of Sokal (1996a, 1996b), it is speculated that the problems with Chomsky were overlooked by cognitive psychologists because his general outlook was accepted. Implications for the editorial review process are discussed.

An Underdiscussed Aspect of Chomsky (1959)

PubMed Central

Adelman, Barry Eshkol

2007-01-01

Chomsky's (1959) review of Skinner's (1957) Verbal Behavior has been influential and attributed with a role in the cognitive revolution. However, while counter reviews from within behavior analysis have noted that Chomsky misunderstood the subject matter, certain aspects of his scholarship have been underdiscussed. This includes several instances where Chomsky misquotes Skinner or takes his quotes out of context. Similar to the findings of Sokal (1996a, 1996b), it is speculated that the problems with Chomsky were overlooked by cognitive psychologists because his general outlook was accepted. Implications for the editorial review process are discussed. PMID:22477378

The Burdenko Neurosurgery Institute: past, present, future.

PubMed

Konovalov, A N; Yartsev, V V; Likhterman, L B

1997-01-01

The Moscow Institute of Neurosurgery was established in 1932. The institute's founders were Nikolai Nilovich Burdenko, the surgeon (his name was later conferred on the institute), and Vasily Vasilyevich Kramer, the neurologist. This article presents the institute's history and its activities in different periods, including scientific and practical achievements in neuro-oncology, cerebrovascular surgery, and neurotraumatology. The institute gave birth to such widely recognized trends as neuropsychology, endovasal neurosurgery, neuroreanimatology (intensive care), and quantitative neuroanatomy. The institute's current problems and prospects for the future are described.

Lineger and Tsibliev during EVA outside Mir Space Station

NASA Image and Video Library

1997-04-29

NM23-48-009 (29 April 1997) --- United States astronaut Jerry M. Linenger, cosmonaut guest researcher, works outside the Russian Mir Space Station during a joint United States-Russian space walk on April 29, 1997. He was joined by Mir-23 commander Vasili V. Tsibliyev (out of frame) for the five-hour Extravehicular Activity (EVA) designed to deploy scientific instruments and retrieve other science hardware. At the top of the frame is a Russian Progress re-supply capsule docked to the Mir’s Kvant-1 module.

STS-111 & Expedition 4 Crew Return Ceremony

NASA Image and Video Library

2002-06-24

JSC2002-E-26023 (21 June 2002) --- Johnson Space Center’s (JSC) Director Jefferson Davis Howell, Jr. speaks from the lectern in Hangar 990 at Ellington Field during the STS-111 and Expedition Four crew return ceremonies. Seated (from left) are General Vasily Tsiblyiev, Deputy Director of the Gagarin Cosmonaut Training Center; cosmonaut Yury I. Onufrienko, Expedition Four mission commander; astronauts Carl E. Walz and Daniel W. Bursch, both Expedition Four flight engineers; and NASA Administrator Sean O'Keefe. Tsiblyiev and Onufrienko represent Rosaviakosmos.

Lineger and Tsibliev during EVA outside Mir Space Station

NASA Image and Video Library

1997-04-29

NM23-48-009 (29 April 1997) --- United States astronaut Jerry M. Linenger, cosmonaut guest researcher, works outside the Russian Mir Space Station during a joint United States-Russian space walk on April 29, 1997. He was joined by Mir-23 commander Vasili V. Tsibliyev (out of frame) for the five-hour Extravehicular Activity (EVA) designed to deploy scientific instruments and retrieve other science hardware. At the top of the frame is a Russian Progress re-supply capsule docked to the Mir’s Kvant-1 module.

110th Anniversary of the Engelhardt Astronomical Observatory

NASA Astrophysics Data System (ADS)

Nefedyev, Y.

2012-09-01

The Engelhardt Astronomical Observatory (EAO) was founded in September 21, 1901. The history of creation of the Engelhard Astronomical Observatory was begun in 1897 with transfer a complimentary to the Kazan University of the unique astronomical equipment of the private observatory in Dresden by known astronomer Vasily Pavlovichem Engelgardt. Having stopped astronomical activity owing to advanced years and illnesses Engelgardt has decided to offer all tools and library of the Astronomical observatory of the Kazan University. Vasily Pavlovich has put the first condition of the donation that his tools have been established as soon as possible and on them supervision are started. In 1898 the decree of Emperor had been allocated means and the ground for construction of the Astronomical observatory is allocated. There is the main historical telescope of the Engelhard Astronomical Observatory the 12-inch refractor which was constructed by English master Grubbom in 1875. The unique tool of the Engelhard Astronomical Observatory is unique in the world now a working telescope heliometer. It's one of the first heliometers, left workshops Repsolda. It has been made in 1874 and established in Engelgardt observatory in 1908 in especially for him the constructed round pavilion in diameter of 3.6 m. Today the Engelhard Astronomical Observatory is the only thing scientifically - educational and cultural - the cognitive astronomical center, located on territory from Moscow up to the most east border of Russia. Currently, the observatory is preparing to enter the protected UNESCO World Heritage List.

Portrait of the Mir 23 crew in the Base Block

NASA Image and Video Library

1997-02-26

NM23-48-003 (29 April 1997) --- Cosmonaut Vasili V. Tsibliyev, Mir-23 commander, operates at the end of the Russian Mir Space Station’s STRELA boom during a space walk on April 29, 1997. He was joined by United States astronaut Jerry M. Linenger, cosmonaut guest researcher, in an effort to deploy scientific instruments and retrieve other science hardware. At the lower left of the picture is the Kvant-1 module. Hovering above it is the Sofora tower, which was once used for an experiment in attitude control of the Mir.

STS-84 and Mir 23 crews take portraits in the Spacehab

NASA Image and Video Library

1997-05-20

STS084-704-015 (15-24 May 1997) --- Crewmembers from Mir-23 and STS-84 assemble for a group portrait onboard the Spacehab Double Module, as they tie a record (ten) for number of persons aboard a single orbiting spacecraft at one time. They are (from the left, front) Jerry M. Linenger, Vasili V. Tsibliyev, Charles J. Precourt, Aleksandr I. Lazutkin and C. Michael Foale. On the back row, from the left, are Edward T. Lu, Eileen M. Collins, Jean-Francois Clervoy, Elena V. Kondakova and Carlos I. Noriega.

Group portrait of STS-84 and Mir 23 crewmembers in the Spacehab

NASA Image and Video Library

1997-06-24

STS084-366-015 (15-24 May 1997) --- Crewmembers from Mir-23 and STS-84 assemble for a group portrait onboard the Spacehab Double Module, as they tie a record (ten) for number of persons aboard a single orbiting spacecraft at one time. They are (from the left, front) Jerry M. Linenger, Vasili V. Tsibliyev, Charles J. Precourt, Aleksandr I. Lazutkin and C. Michael Foale. On the back row, from the left, are Edward T. Lu, Eileen M. Collins, Jean-Francois Clervoy, Elena V. Kondakova and Carlos I. Noriega.

78 FR 51803 - Culturally Significant Objects Imported for Exhibition Determinations: “Vasily Kandinsky: From...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... of Authority No. 234 of October 1, 1999, and Delegation of Authority No. 236-3 of August 28, 2000.... Department of State, SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC 20522-0505. Dated: August 14, 2013...

Interferon-alpha in chronic myeloid leukemia revisited: a long-term retrospective study in Central and Northern Moravia.

PubMed

Faber, Edgar; Kuba, Adam; Zapletalova, Jana; Divoka, Martina; Rohon, Peter; Holzerova, Milena; Jarosova, Marie; Indrak, Karel

2013-09-01

We assessed the long-term outcome of consecutive patients in the chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (INF-α) in Central and Northern Moravia between 1989 and 2006. A retrospective study focused on the response, prognostic factors and side-effects of INF-α. 118 patients (67 males and 51 females, median age 50 years; range 18-71) were analyzed. The median follow-up was 82.6 months (12.4-212.6). Thirty-six patients (30.5%) achieved major cytogenetic response (CyR) in median of 18.3 months (3.7-47.3) and maintained it for a median of 64.0 months (7.0-176.0). Sixty-one patients treated with INF-α for more than 12 months had an overall survival (OS) of 137.0 months (95% CI 117.6-156.4). Eighteen (29.5%) achieved complete CyR (CCyR). 109 patients discontinued the treatment with INF-α because of hematologic or cytogenetic resistance in 53 (48.7%), progression of CML in 31 (28.4%) and intolerance to INF-α in 17 (15.6%) patients. The percentage of peripheral blasts, leukocyte count (>50x10(9)/L), splenomegaly, anemia (Hgb≤110 g/L) and Sokal score had statistical impact on the OS in univariate assessment but only the Sokal score remained significant in multivariate analysis. Additional cytogenetic abnormalities at diagnosis were associated with poor prognosis. In most patients, treatment with INF-α had to be stopped because of a failure to induce response, progression of CML or side-effects but nearly one third of patients treated at least for one year had a long-term benefit from INF-α. The best prognosis was associated with achievement of CCyR and negativity of BCR-ABL in nested RT-PCR.

STS-84 and Mir 23 crewmembers exchange gifts during meal after docking

NASA Image and Video Library

1997-05-17

STS084-377-026 (15-24 May 1997) --- Cosmonaut Elena V. Kondakova opens a gift box and a number of tiny chocolate Space Shuttles free-float in Russia's Mir Space Station's Base Block. The STS-84 mission specialist and her crew mates had earlier presented the gift to the Mir-23 crew members, including Vasili Tsibliyev (right), mission commander. In the background are astronauts Eileen M. Collins, STS-84 pilot, and Jerry M. Linenger, mission specialist. Linenger was in his last days aboard Mir prior to returning to Earth with the STS-84 crew aboard the Space Shuttle Atlantis.

Summary of Meteorological Observations, Surface (SMOS) for Misawa, Japan.

DTIC Science & Technology

1985-03-01

SPECLIAL DATE ACCESSIONED DISTRIBUTION STAMP _ _ _ _ _ _ _DATE RETURNED 85 3 25 098 DATE RBCEIE IN DK REGISTERED OR CERTIFIED NO. PIT OGRAPH THS IBMT AMD...SPIED .1MEAN tINTS) I .3 4 7 10 11 16 17 21I 22 27 20 33 34 40 41 47 48 55 ~ 56 % WINO pit SPEED TE ± ---- -. ---- -- - - --------- SIR 4_4. WSW Sw L.1...8217 IT. 4 ____ 2. nnnm ~ ___nn ___mlln u .unm m _ - 1. 4.1 WNW 1e__ 3 1 VASILi - CALMA >ɚ ____ _ 1____ 2 2 ,3 Z. 1 .3 b- TOTAL NUMIN OF OSSEt VATIO#46

HOXA9 gene expression in the chronic myeloid leukemia progression.

PubMed

Tedeschi, Fabian A; Zalazar, Fabian E

2006-11-01

In the present work we study the HOXA9 expression in sequential samples of patients with CML using RT-PCR. To obtain a semi-quantitative value, the HOXA9 expression was referred to the ABL gene in the same sample. The relative HOXA9 expression was higher in patients in the accelerated phase of the disease (p<0.005). Interestingly, a patient with poorer prognosis (high Sokal's score), showing the highest HOXA9/ABL ratio, quickly entered a blast crisis and died 5 months later. These first results could be considered as an evidence of an actual biological phenomenon that could provide additional information about the HOXA9 role in the CML progression.

Chronic myeloid leukemia patients in Tunisia: epidemiology and outcome in the imatinib era (a multicentric experience).

PubMed

Ben Lakhal, Raihane; Ghedira, Hela; Bellaaj, Hatem; Ben Youssef, Yosra; Menif, Samia; Manai, Zeineb; Bedoui, Manel; Lakhal, Amel; M'Sadek, Fehmi; Elloumi, Moez; Khélif, Abderrahmane; Ben Romdhane, Neila; Laatiri, Mohamed Adnène; Ben Othmen, Tarek; Meddeb, Balkis

2018-04-01

Data are limited in developing countries regarding the clinicopathologic features and response to therapy of chronic myeloid leukemia (CML) in the era of imatinib (IM). The objective of this study is to report on the clinicoepidemiologic features of CML in Tunisia, to evaluate the long-term outcome of patients in chronic (CP) or accelerated phase (AP) treated with IM 400 mg daily as frontline therapy, and to determine imatinib's efficacy and safety. From October 2002 to December 2014, 410 CML patients were treated with IM in six Tunisian departments of hematology. Response (hematologic, cytogenetic, and molecular responses) and outcome-overall survival (OS), event-free survival (EFS), and progression-free survival (PFS)-were evaluated. The following prognostic factors were analyzed for their impact on the European leukemia net (ELN) response, OS, EFS, and PFS at 5 years: age, sex, leukocyte count, Sokal score, European Treatment and Outcome Study (EUTOS) score, CML phase, time to starting IM, and impact of adverse events. The median age was 45 years (3-85 years). Two hundred ten (51.2%) patients were male. Splenomegaly was present in 322 of the 410 (79%). Additional cytogenetic abnormalities were encountered in 25 (6.3%) patients. At diagnosis, 379 (92.4%) patients were in CP, 31 (7.6%) were in AP. The Sokal risk was low in 87 (22.5%), intermediate in 138 (35.7%), and high in 164 patients (41.9%). The EUTOS risk was low in 217 (74%), and high in 77 (26%) patients. The rates of cumulative complete cytogenetic response (CCyR), major molecular response (MMR), and molecular response 4/5 log (MR4.5) in CP/AP-CML patients were 72, 68.4, and 46.4%, respectively. The median time to reach CCyR, MMR, and MR4.5 was 6 months (3-51), 18 months (3-72), and 24 months (3-100), respectively. According to the ELN criteria, optimal, suboptimal response, and failure were noted in 206 (51.8%), 61 (15.3%), and 125 (31.4%) patients, respectively. Five-year event-free survival (EFS

Mir 21 crew portraits

NASA Image and Video Library

1995-07-14

S95-16674 (14 July 1995) --- On the left is the Mir-21 crew consisting of cosmonaut Yuriy V. Usachov (standing), flight engineer; Yuriy I. Onufriyenko (seated), commander; and Shannon W. Lucid, cosmonaut guest researcher. On the right side is the Mir-23 crew consisting of John E. Blaha (standing), cosmonaut guest researcher; Vasili V. Tsibliyev (seated), commander; and Aleksandr I. Lazutkin, flight engineer. NASA astronauts Lucid and Blaha each will go into space to board Russia's Mir Space Station for lengthy research on their respective missions. Lucid will board the Mir during the STS-76 mission. Blaha will replace Lucid onboard the Mir during the STS-79 mission.

The Mishin Diaries, a new significant primary source of space history information

NASA Astrophysics Data System (ADS)

Payson, Dmitry; Alifanov, Oleg; Moiseev, Ivan; Vick, Charles; Woods, David

2016-06-01

Vasily Mishin (1917-2001) was a prominent Russian engineer and scientist: one of the pioneers who made spaceflight a reality. In 2014 diaries that were maintained by Mishin from 1960 to 1974 (the Mishin Diaries) had been transcribed and published and can now serve as an extensive resource for first-hand historical information about that fascinating period of time. The original Diaries are now owned by the Perot Foundation and copies were generously provided by them to the Moscow Aviation Institute for this transcription project. The actual publication was made possible by Mishin's students, co-workers, family members as well as numerous spaceflight historians and enthusiasts.

Final Scientific EFNUDAT Workshop

ScienceCinema

None

2018-05-23

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities ; International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) ;Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis;Workshop Assistant: Geraldine Jean

Final Scientific EFNUDAT Workshop

ScienceCinema

Garbil, Roger

2018-04-16

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden). Workshop Organizing Committee: Enrico Chiaveri (Chairman); Marco Calviani; Samuel Andriamonje; Eric Berthoumieux; Carlos Guerrero; Roberto Losito; Vasilis Vlachoudis; Workshop Assistant: Geraldine Jean

STS-111 & Expedition 4 Crew Return Ceremony

NASA Image and Video Library

2002-06-24

JSC2002-E-26021 (21 June 2002) --- Johnson Space Center’s (JSC) Director Jefferson Davis Howell, Jr. speaks from the lectern in Hangar 990 at Ellington Field during the STS-111 and Expedition Four crew return ceremonies. Seated (from left) are General Vasily Tsiblyiev, Deputy Director of the Gagarin Cosmonaut Training Center; cosmonaut Yury I. Onufrienko, Expedition Four mission commander; astronauts Carl E. Walz and Daniel W. Bursch, both Expedition Four flight engineers; NASA Administrator Sean O'Keefe; astronauts Kenneth D. Cockrell, STS-111 mission commander; Paul S. Lockhart, pilot; Franklin R. Chang-Diaz and Philippe Perrin, both mission specialists. Tsiblyiev and Onufrienko represent Rosaviakosmos, and Perrin represents CNES, the French Space Agency.

Milestones of space medicine development in Russia (establishment and evolution of the Institute of Biomedical Problems).

PubMed

Gazenko, O G

1997-10-01

This paper describes the history of the Institute of Biomedical Problems (IMBP): its birth and development. IMBP's directors were: Andrei V. Libedinsky (1963-1965), Vasily V. Parin (1965-1967), Oleg G. Gazenko (1968-1988), and Anatoly I. Grigoriev (1988 to the present). Most of the early employees of IMBP came from the USSR Air Force Institute of Aviation Medicine and the USSR Ministry of Health Institute of Biophysics. The major goals of IMBP were: development of a system of medical monitoring and support of long-duration space missions, selection and training of civilian crew members, bioengineering testing of flight equipment, and development of life support system concepts and requirements. The paper presents major results of the above research activities.

STS-105 Expedition 2 Return

NASA Image and Video Library

2001-08-23

JSC2001-E-25809 (23 August 2001) --- The STS-105 and Expedition Two crews meet their families and friends during the crew return ceremonies at Ellington Field. Among the crowd are Johnson Space Center's (JSC) Acting Director Roy Estess (back left), astronaut Marsha S. Ivins (third from the left), cosmonaut Yury V. Usachev (fourth from the left), Expedition Two mission commander, Susan J. Helms (fifth from the left), Expedition Two flight engineer, James S. Voss (third from the right), Expedition Two flight engineer, and cosmonaut Vasili V. Tsibliyev. The STS-105 crew delivered the Expedition Three crew and supplies to the International Space Station (ISS) and brought the Expedition Two crew back to Earth.

Final Scientific EFNUDAT Workshop

ScienceCinema

None

2018-05-24

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) & Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis; Workshop Assistant: Geraldine Jean

Final Scientific EFNUDAT Workshop

ScienceCinema

None

2018-06-20

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation, Cross section measurements, Experimental techniques, Uncertainties and covariances, Fission properties, and Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France), T. Belgya (IKI KFKI, Hungary), E. Gonzalez (CIEMAT, Spain), F. Gunsing (CEA, France), F.-J. Hambsch (IRMM, Belgium), A. Junghans (FZD, Germany), R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman), Marco Calviani, Samuel Andriamonje, Eric Berthoumieux, Carlos Guerrero, Roberto Losito, Vasilis Vlachoudis. Workshop Assistant: Geraldine Jean

Final Scientific EFNUDAT Workshop

ScienceCinema

Lantz, Mattias; Neudecker, Denise

2018-05-25

Part 5 of The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium) A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis Workshop Assistant: Geraldine Jean

Final Scientific EFNUDAT Workshop

ScienceCinema

Wilson, J.N.

2018-05-24

Part 7 of The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive.EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities;International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium) A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman) Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis Workshop Assistant: Geraldine Jean.

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garbil, Roger

2010-11-09

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden). Workshop Organizing Committee: Enrico Chiaveri (Chairman); Marco Calviani; Samuel Andriamonje; Eric Berthoumieux; Carlos Guerrero; Robertomore » Losito; Vasilis Vlachoudis; Workshop Assistant: Geraldine Jean« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, J.N.

2010-11-09

Part 7 of The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive.EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities;International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium) A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman) Marco Calvianimore » Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis Workshop Assistant: Geraldine Jean.« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lantz, Mattias; Neudecker, Denise

2010-11-09

Part 5 of The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium) A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuelmore » Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis Workshop Assistant: Geraldine Jean« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vlachoudis, Vasilis

2010-11-09

Part 8. The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu Topics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany) R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Ericmore » Berthoumieux Carlos Guerrero Roberto LositoVasilis Vlachoudis Workshop Assistant: Geraldine Jean« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-11-09

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) & Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuelmore » Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis; Workshop Assistant: Geraldine Jean« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-11-09

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities ; International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) ;Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Lositomore » Vasilis Vlachoudis;Workshop Assistant: Geraldine Jean« less

Final Scientific EFNUDAT Workshop

ScienceCinema

None

2017-12-09

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive.EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluationCross section measurementsExperimental techniquesUncertainties and covariancesFission propertiesCurrent and future facilities  International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco CalvianiSamuel AndriamonjeEric BerthoumieuxCarlos GuerreroRoberto LositoVasilis Vlachoudis Workshop Assistant: Géraldine Jean

Comittees

NASA Astrophysics Data System (ADS)

2004-10-01

Fritz Caspers (CERN, Switzerland), Michel Chanel (CERN, Switzerland), Håkan Danared (MSL, Sweden), Bernhard Franzke (GSI, Germany), Manfred Grieser (MPI für Kernphysik, Germany), Dieter Habs (LMU München, Germany), Jeffrey Hangst (University of Aarhus, Denmark), Takeshi Katayama (RIKEN/Univ. Tokyo, Japan), H.-Jürgen Kluge (GSI, Germany), Shyh-Yuan Lee (Indiana University, USA), Rudolf Maier (FZ Jülich, Germany), John Marriner (FNAL, USA), Igor Meshkov (JINR, Russia), Dieter Möhl (CERN, Switzerland), Vasily Parkhomchuk (BINP, Russia), Robert Pollock (Indiana University), Dieter Prasuhn (FZ Jülich, Germany), Dag Reistad (TSL, Sweden), John Schiffer (ANL, USA), Andrew Sessler (LBNL, USA), Alexander Skrinsky (BINP, Russia), Markus Steck (GSI, Germany), Jie Wei (BNL, USA), Andreas Wolf (MPI für Kernphysik, Germany), Hongwei Zhao (IMP, People's Rep. of China).

The stretching of Hercules

NASA Astrophysics Data System (ADS)

Deason, A. J.; Belokurov, V.; Evans, N. W.; Watkins, L. L.; Fellhauer, M.

2012-09-01

We present VLT/FORS2 spectroscopy of candidate blue horizontal branch (BHB) stars in the vicinity of the Hercules ultrafaint dwarf galaxy. We identify eight convincing Hercules BHB members, and a further five stars with similar systemic velocities to that of Hercules, but ˜0.5 kpc from the centre of the galaxy along its major axis. It is likely that these stars once belonged to Hercules, but have been tidally stripped and are now unbound. We emphasize the usefulness of looking for any gradient in the systemic velocity of this stretched system, which would further support our interpretation of the origin of its elongated and distended morphology. E-mail: ajd75@ast.cam.ac.uk (AJD); vasily@ast.cam.ac.uk (VB); nwe@ast.cam.ac.uk (NWE)

STS-84 Day 07 Highlights

NASA Technical Reports Server (NTRS)

1995-01-01

On this seventh day of the STS-84 mission, the flight crew, Cmdr. Charles J. Precourt, Pilot Eileen M. Collions, Payload Cmdr, Jean-Francois Clervoy (ESA), Mission Specialists Edward T. Lu; Carlos I. Noriega; Elena V. Kondakova; Jerry M. Linenger (download) and C. Michael Foale (upload) are seen saying their final farewells and closing the hatches on their two spacecraft. This wrap up five days of joint operations in which about 7,000 pounds of supplies, experiments and water were transferred between the two vehicles, as well as astronaut Mike Foale, who swapped places with Jerry Linenger for the start of a four-month research mission on the Russian outpost. The final handshakes by Commanders Charlie Precourt and Vasily Tsibliev came moments before the hatches between Atlantis and Mir swung shut.

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kappeler, Franz

2010-11-09

F. Kappeler speaks about EFNUDAT synergies in astrophysics in this second session of the Final Scientific EFNUDAT Workshop. The workshop was organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities; International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany) R. Nolte (PTB, Germany)S. Pomp (TSLmore » UU, Sweden);Workshop Organizing Committee: Enrico Chiaveri (Chairman) Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis Workshop Assistant: Geraldine Jean.« less

Analyzing the effect of the distortion compensation in reversible watermarking

NASA Astrophysics Data System (ADS)

Kim, Suah; Kim, Hyoung Joong

2014-01-01

Reversible watermarking is used to hide information in images for medical and military uses. Reversible watermarking in images using distortion compensation proposed by Vasily et al [5] embeds each pixel twice such that distortion caused by the first embedding is reduced or removed by the distortion introduced by the second embedding. In their paper, because it is not applied in its most basic form, it is not clear whether improving it can achieve better results than the existing state of the art techniques. In this paper we first provide a novel basic distortion compensation technique that uses same prediction method as Tian's [2] difference expansion method (DE), in order to measure the effect of the distortion compensation more accurately. In the second part, we will analyze what kind of improvements can be made in distortion compensation.

Final crew portrait of STS-84 and Mir 23 crew in the Spacehab

NASA Image and Video Library

1997-05-22

STS084-380-019 (15-24 May 1997) --- In the last minutes of joint activity between the STS-84 and Russian Space Agency (RSA) Mir-23 crews, ten astronauts and cosmonauts pose for an in-space portrait in the Space Shuttle Atlantis Spacehab Double Module (DM). For orientation purposes, photo should be held with clasped hands of Aleksandr I. Lazutkin (wearing Mir-23 suit) just below center. The flight engineer is flanked by similarly attired crew mates Vasili Tsibliyev, Mir-23 commander, on the left, and C. Michael Foale, cosmonaut guest researcher, on the right. The STS-84 crew members are, clockwise from the left, Jerry M. Linenger, mission specialist; Eileen M. Collins, pilot; Edward T. Lu, mission specialist; Jean-Fran?ois Clervoy, payload commander; Elena V. Kondakova and Carlos I. Noriega, both mission specialists, along with Charles J. Precourt, mission commander.

The Dokuchaev hypothesis as a basis for predictive digital soil mapping (on the 125th anniversary of its publication)

NASA Astrophysics Data System (ADS)

Florinsky, I. V.

2012-04-01

Predictive digital soil mapping is widely used in soil science. Its objective is the prediction of the spatial distribution of soil taxonomic units and quantitative soil properties via the analysis of spatially distributed quantitative characteristics of soil-forming factors. Western pedometrists stress the scientific priority and principal importance of Hans Jenny's book (1941) for the emergence and development of predictive soil mapping. In this paper, we demonstrate that Vasily Dokuchaev explicitly defined the central idea and statement of the problem of contemporary predictive soil mapping in the year 1886. Then, we reconstruct the history of the soil formation equation from 1899 to 1941. We argue that Jenny adopted the soil formation equation from Sergey Zakharov, who published it in a well-known fundamental textbook in 1927. It is encouraging that this issue was clarified in 2011, the anniversary year for publications of Dokuchaev and Jenny.

STS-84 Day 03 Highlights

NASA Technical Reports Server (NTRS)

1995-01-01

On this third day of the STS-84 mission, the flight crew, Cmdr. Charles J. Precourt, Pilot Eileen M. Collins, Payload Cmdr, Jean-Francois Clervoy (ESA), Mission Specialists Edward T. Lu, Carlos I. Noriega, Elena V. Kondakova, Jerry M. Linenger (download), and C. Michael Foale (upload) guide Atlantis to its docking with the Mir to cap off a 42-hour chase. Precourt greets Mir 23 Commander Vasily Tsibliev and, after embraces and handshakes, the crew members make their way into the Mir Core Module for a brief welcoming ceremony. During the ceremony, the Shuttle crew give Tsibliev and Flight Engineer Alexander Lazutkin baseball caps emblazoned with the STS-84 crew insignia as well as the traditional Russian offering of bread, tea and salt. Then, the ten astronauts and cosmonauts get down to business, first conducting a joint safety briefing to familiarize themselves with each other's craft.

Treatment patterns and prognostic indicators of response to therapy among patients with chronic myeloid leukemia in Australia, Canada, and South Korea.

PubMed

Whiteley, Jennifer; Iyer, Shrividya; Candrilli, Sean D; Kaye, James A

2015-02-01

Given the multiple options for treatment of chronic-phase chronic myeloid leukemia (CML) with tyrosine kinase inhibitors, our objective was to understand treatment patterns in routine practice and prognostic indicators of response. We conducted a retrospective medical record review of 681 patients with CML in Australia, Canada, and South Korea. Eligible patients had a diagnosis of chronic-phase CML, were Philadelphia chromosome and/or BCR-ABL positive, were aged 18 years or older, and had been treated with first-line imatinib therapy between January 2005 and September 2010. Data on patient demographics, medical history (e.g., comorbidities, Sokal score), and treatment characteristics (e.g., time to initiation, therapy duration) were abstracted. Descriptive analyses were stratified by country and therapy line. Prognostic indicators of response to imatinib were evaluated using multivariable logistic regression, adjusting for country, patient demographics, medical history, treatment characteristics, and side effects. Hematologic, cytogenetic, and molecular responses at 3, 6, 12, and 18 months following initiation of each therapy line. Patients' average age was 57 years, and 59% were male. Overall, imatinib was initiated approximately 4 months following CML diagnosis. Complete or major molecular response (C/MMR) at 6 months following imatinib initiation was 54% in Australia, 22% in Canada, and 38% in South Korea. At 18 months, over 60% of patients achieved C/MMR. Approximately 30% of patients discontinued imatinib primarily due to intolerance and lack of response. Among patients who received second-line treatment, dasatinib was used more frequently than nilotinib. Multivariable regression results indicated Sokal score was identified as a prognostic indicator of response to imatinib therapy at several time points. There are several limitations to this study. First, we selected a convenience sample of patients and physicians and therefore results may not be

Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score.

PubMed

Hasford, Joerg; Baccarani, Michele; Hoffmann, Verena; Guilhot, Joelle; Saussele, Susanne; Rosti, Gianantonio; Guilhot, François; Porkka, Kimmo; Ossenkoppele, Gert; Lindoerfer, Doris; Simonsson, Bengt; Pfirrmann, Markus; Hehlmann, Rudiger

2011-07-21

The outcome of chronic myeloid leukemia (CML) has been profoundly changed by the introduction of tyrosine kinase inhibitors into therapy, but the prognosis of patients with CML is still evaluated using prognostic scores developed in the chemotherapy and interferon era. The present work describes a new prognostic score that is superior to the Sokal and Euro scores both in its prognostic ability and in its simplicity. The predictive power of the score was developed and tested on a group of patients selected from a registry of 2060 patients enrolled in studies of first-line treatment with imatinib-based regimes. The EUTOS score using the percentage of basophils and spleen size best discriminated between high-risk and low-risk groups of patients, with a positive predictive value of not reaching a CCgR of 34%. Five-year progression-free survival was significantly better in the low- than in the high-risk group (90% vs 82%, P = .006). These results were confirmed in the validation sample. The score can be used to identify CML patients with significantly lower probabilities of responding to therapy and survival, thus alerting physicians to those patients who require closer observation and early intervention.

STS-85 Day 08 Highlights

NASA Technical Reports Server (NTRS)

1997-01-01

On this eighth day of the STS-85 mission, the flight crew, Cmdr. Curtis L. Brown, Jr., Pilot Kent V. Rominger, Payload Cmdr. N. Jan Davis (Ph.D.), Mission Specialists Robert L. Curbeam, Jr. and Stephen K. Robinson (Ph.D.), and Payload Specialist Bjarni V. Tryggvason entered the final portion of its flight. The new Mir 24 crew of Commander Anatoly Solovyev and Flight Engineer Pavel Vinogradov, who arrived on the station the same day Discovery was launched, bid farewell to Mir 23 Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin who are returning home after 185 days in space. The Soyuz vehicle carrying the Mir 23 crew home undocked from the station. Robinson again used the Southwest Ultraviolet Imaging System (SWUIS), a 7-inch imaging telescope that is pointed out of the orbiter's middeck hatch window, to observe the Hale-Bopp comet. Curbeam continued his work with the Bioreactor Demonstration System designed to perform cell biology experiments under controlled conditions. Tryggvason spent part of his time troubleshooting a computer hard drive system that supports the Microgravity Vibration Isolation Mount experiment.

Synaesthesia, the arts and creativity: a neurological connection.

PubMed

Mulvenna, Catherine M

2007-01-01

For over 100 years the link between synaesthesia and the arts has attracted controversy. This has been spurred by the production of auditory, literary and visual art by famous individuals who report experiences synonymous with the neurological condition. Impressive protagonists in this discussion include Arthur Rimbaud, Charles Baudelaire, Vasily Kandinsky, Vladimir Nabokov, Alexander Scriabin, Olivier Messiaen and David Hockney. Interdisciplinary debates have concerned whether synaesthesia can actively contribute to an artist's ability, whether it is a driving force or a mere idiosyncratic quirk and whether, fundamentally, it is a distinct idiopathic condition or an unusual metaphorical description of normal perception. Recent psychological and neuroscientific evidence offers a new level to the debate. Coherent patterns of a neural basis of synaesthesia have been confirmed with high spatial resolution brain imaging techniques and the link with the arts is transpiring to be more than superficial or coincidental. Moreover, the neural distinction of the synaesthete brain may prove to be a window into a neural basis of creative cognition, and therefore conducive to the expression of creativity in various media.

The Role of New Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

PubMed Central

Pophali, Priyanka A.; Patnaik, Mrinal M.

2015-01-01

Imatinib mesylate was the first tyrosine kinase inhibitor (TKI) approved for the management of chronic myeloid leukemia (CML). Imatinib produces acceptable responses in ~ 60% of patients; with ~20% discontinuing therapy due to intolerance and ~20% developing drug resistance. The advent of newer TKIs’ such as, nilotinib, dasatinib, bosutinib and ponatinib have provided multiple options for patients. These agents are more potent, have unique side effect profiles and are more likely to achieve relevant milestones such as, early molecular responses (3-6 months) and optimal molecular responses (12 months). The acquisition of BCR-ABL kinase domain mutations is also reportedly lower with these drugs. Thus far, none of the randomized phase III clinical trials have shown a clinically significant survival difference between frontline imatinib versus newer TKIs’. Cost and safety issues with the newer TKIs’ such as, vascular disease with nilotinib and ponatinib and pulmonary hypertension with dasatinib have dampened the enthusiasm of using these drugs as frontline options. While the utility of new TKIs’ in the setting of imatinib failure or intolerance is clear, their use as frontline agents should factor in the age of the patient, additional comorbidities, risk stratification (Sokal score) and cost. Combination therapies and newer agents with potential to eradicate quiescent CML stem cells offer future hope. PMID:26841016

The methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism increases the risk of developing chronic myeloid leukemia-a case-control study.

PubMed

Bănescu, Claudia; Iancu, Mihaela; Trifa, Adrian P; Macarie, Ioan; Dima, Delia; Dobreanu, Minodora

2015-04-01

The methylenetetrahydrofolate reductase (MTHFR) 677 C>T and 1298 A>C polymorphisms are associated with variations in folate levels, a phenomenon linked to the development of various malignancies. The aim of this study was to investigate the influence of the 677 C>T and 1298 A>C polymorphisms in the MTHFR gene on the risk of developing chronic myeloid leukemia (CML). Our study included 151 patients with CML and 305 controls. The MTHFR 677 C>T and 1298 A>C polymorphisms were investigated by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and allele-specific PCR techniques. The CT and TT genotypes of the MTHFR 677 C>T polymorphism were associated with an increased risk of developing CML (odds ratio (OR) = 1.556, 95% confidence interval (CI) = 1.017-2.381, p value = 0.041, and OR = 1.897, 95% CI = 1.046-3.44, p value = 0.035, respectively). No association was observed between the prognostic factors (blasts, basophils, additional chromosomal abnormalities, EUTOS score, Sokal and Hasford risk groups) and the MTHFR 677 C>T and 1298 A>C variant genotypes in CML patients. Our study shows that the MTHFR 677 C>T polymorphism is significantly associated with the risk of CML in Romanian patients.

Long-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trial.

PubMed

Hochhaus, A; Saglio, G; Hughes, T P; Larson, R A; Kim, D-W; Issaragrisil, S; le Coutre, P D; Etienne, G; Dorlhiac-Llacer, P E; Clark, R E; Flinn, I W; Nakamae, H; Donohue, B; Deng, W; Dalal, D; Menssen, H D; Kantarjian, H M

2016-05-01

In the phase 3 Evaluating Nilotinib Efficacy and Safety in Clinical Trials-Newly Diagnosed Patients (ENESTnd) study, nilotinib resulted in earlier and higher response rates and a lower risk of progression to accelerated phase/blast crisis (AP/BC) than imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP). Here, patients' long-term outcomes in ENESTnd are evaluated after a minimum follow-up of 5 years. By 5 years, more than half of all patients in each nilotinib arm (300 mg twice daily, 54%; 400 mg twice daily, 52%) achieved a molecular response 4.5 (MR(4.5); BCR-ABL⩽0.0032% on the International Scale) compared with 31% of patients in the imatinib arm. A benefit of nilotinib was observed across all Sokal risk groups. Overall, safety results remained consistent with those from previous reports. Numerically more cardiovascular events (CVEs) occurred in patients receiving nilotinib vs imatinib, and elevations in blood cholesterol and glucose levels were also more frequent with nilotinib. In contrast to the high mortality rate associated with CML progression, few deaths in any arm were associated with CVEs, infections or pulmonary diseases. These long-term results support the positive benefit-risk profile of frontline nilotinib 300 mg twice daily in patients with CML-CP.

Two new terrestrial species of Hydraena Kugelann from the island of Bioko, Gulf of Guinea (Coleoptera: Hydraenidae).

PubMed

Hernando, Carles; Ribera, Ignacio

2017-03-02

The knowledge of the Hydraenidae of sub-Saharan Africa, and in particular of the genus Hydraena Kugelann, 1794, is most incomplete. As an example, in southern Africa only three species were described before the revision of Perkins (2014), which raised the number to 31. Only 15 species are currently known from Central Africa, between the Sahel and South Africa, all belonging to subgenus Hydraenopsis Janssens, 1972 (Trizzino et al. 2013), but many more remain to be described and discovered. The islands of the Gulf of Guinea are no exception to this lack of knowledge (Jones 1994), and only one species of the family was previously known, H. (Hydraenopsis) pagaluensis Hernando & Ribera, 2001 from Annobón (Hernando & Ribera 2001; Trizzino et al. 2013). In this paper we describe the first known species of Hydraenidae from Bioko, the largest and closest to the continent of these islands. The species were collected by our friend and colleague Vasily Grebennikov during a survey of the forest litter fauna of Annobón and Bioko. Despite considerable efforts no Hydraenidae were found in Annobón, and only these two species, in a single locality, in Bioko.

STS-84 Day 08 Highlights

NASA Technical Reports Server (NTRS)

1995-01-01

On this eighth day of the STS-84 mission, the flight crew, Cmdr. Charles J. Precourt, Pilot Eileen M. Collins, Payload Cmdr, Jean-Francois Clervoy (ESA), Mission Specialists Edward T. Lu, Carlos I. Noriega, Elena V. Kondakova, Jerry M. Linenger (download), and C. Michael Foale (upload) sing 'The Cosmonauts' Song' to Mir-23 crew members Vasily Tsibliev, Alexander Lazutkin and astronaut Mike Foale, who is beginning his four-month research mission on Mir. Foale and his new crewmates played music as Atlantis departed following the joint phase of the flight. Atlantis' undocking from Mir was modified from previous joint missions in that a flyaround of the station for photographic purposes was not conducted. Instead, Pilot Eileen Collins guided Atlantis below the Mir after the two spacecraft completed their physical separation, stopping three times at distances of 90, 300 and 1,500 feet to collect data from a European sensor device designed to assist future rendezvous of a proposed European Space Agency resupply vehicle with the International Space Station. Once the data collection was completed, the shuttle took advantage of natural orbital mechanics to drift beneath and out in front of Mir.

Splitting in large dimension and infrared estimates. II. Moment inequalities

NASA Astrophysics Data System (ADS)

Helffer, B.

1998-02-01

This is the continuation of notes written for the NATO-ASI conference in Il Ciocco (September 96) consisting of the analysis of the links between estimating the splitting between the two first eigenvalues for the Schrödinger operator H and the proof of infrared estimates for quantities attached to Gaussian-type measures. These notes were mainly reporting on the "old" contributions of Dyson, Fröhlich, Glimm, Jaffe, Lieb, Simon, and Spencer (in the 1970s) in connection with more recent contributions of Pastur, Khoruzhenko, Barbulyak, and Kondrat'ev which treat in general more sophisticated models. Here we concentrate on the simplest model related to field theory and extend the results of Barbulyak and Kondrat'ev by mixing ideas coming from Pastur and Khozurenko related to the use of Bogolyubov's inequality with classical inequalities due to Ginibre, Lebowitz, Sokal, and others, or, in the case when the temperature T is zero, by applying rather elementary estimates on Schrödinger operators, in order to find lower bounds for second-order moments attached to the measure φ⟼Trφ exp-βH/Tr exp-βH with β=1/T. This question was "left to the reader" in lectures given by J. Fröhlich in 1976 [Acta Phys. Austriaca, Suppl. XV, 133-269 (1976)], but we think that it is worthwhile to do this "homework" carefully.

How I determine if and when to recommend stopping tyrosine kinase inhibitor treatment for chronic myeloid leukaemia.

PubMed

Ross, David M; Hughes, Timothy P

2014-07-01

Treatment-free remission (TFR) has recently emerged as a goal of treatment in chronic myeloid leukaemia (CML). Molecular remission is sustained in around 30% of imatinib-treated patients who stop treatment after ≥2 years with undetectable minimal residual disease (UMRD) by conventional real-time reverse transcription polymerase chain reaction. An additional 20-30% of patients will lose UMRD, but remain in stable major molecular remission off treatment. Most patients with molecular recurrence have a significant increase in BCR-ABL1 within the first 6 months off treatment, but there are also rare late relapses. As re-treatment with imatinib restores control, a trial of TFR is safe so long as careful molecular monitoring is provided to enable prompt re-treatment. The minimum eligibility criteria for a trial of TFR are not yet defined, but the available data support a MRD level of around a molecular response of 4.5 log for at least 2 years. Factors associated with a higher probability of TFR include low risk Sokal score, prior interferon treatment, longer total duration of imatinib treatment and higher numbers of natural killer cells at the time of imatinib discontinuation. Preliminary data suggest that the rate of TFR in patients treated with more potent tyrosine kinase inhibitors will probably be higher. The biology that underlies TFR is an area of active investigation. © 2014 John Wiley & Sons Ltd.

PTCH1 expression at diagnosis predicts imatinib failure in chronic myeloid leukaemia patients in chronic phase.

PubMed

Alonso-Dominguez, Juan M; Grinfeld, Jacob; Alikian, Mary; Marin, David; Reid, Alistair; Daghistani, Mustafa; Hedgley, Corinne; O'Brien, Stephen; Clark, Richard E; Apperley, Jane; Foroni, Letizia; Gerrard, Gareth

2015-01-01

The tyrosine kinase inhibitor (TKI) imatinib has revolutionized the management of chronic myeloid leukaemia (CML). However, around 25% of patients fail to sustain an adequate response. We sought to identify gene-expression biomarkers that could be used to predict imatinib response. The expression of 29 genes, previously implicated in CML pathogenesis, were measured by TaqMan Low Density Array in 73 CML patient samples. Patients were divided into low and high expression for each gene and imatinib failure (IF), probability of achieving CCyR, progression free survival and CML related OS were compared by Kaplan-Meier and log-rank. Results were validated in a second cohort of 56 patients, with a further technical validation using custom gene-expression assays in a conventional RT-qPCR in a sub-cohort of 37 patients. Patients with low PTCH1 expression showed a worse clinical response for all variables in all cohorts. PTCH1 was the most significant predictor in the multivariate analysis compared with Sokal, age and EUTOS. PTCH1 expression assay showed the adequate sensitivity, specificity and predictive values to predict for IF. Given the different treatments available for CML, measuring PTCH1 expression at diagnosis may help establish who will benefit best from imatinib and who is better selected for second generation TKI. © 2014 Wiley Periodicals, Inc.

Virtual screening by a new Clustering-based Weighted Similarity Extreme Learning Machine approach

PubMed Central

Kudisthalert, Wasu

2018-01-01

Machine learning techniques are becoming popular in virtual screening tasks. One of the powerful machine learning algorithms is Extreme Learning Machine (ELM) which has been applied to many applications and has recently been applied to virtual screening. We propose the Weighted Similarity ELM (WS-ELM) which is based on a single layer feed-forward neural network in a conjunction of 16 different similarity coefficients as activation function in the hidden layer. It is known that the performance of conventional ELM is not robust due to random weight selection in the hidden layer. Thus, we propose a Clustering-based WS-ELM (CWS-ELM) that deterministically assigns weights by utilising clustering algorithms i.e. k-means clustering and support vector clustering. The experiments were conducted on one of the most challenging datasets–Maximum Unbiased Validation Dataset–which contains 17 activity classes carefully selected from PubChem. The proposed algorithms were then compared with other machine learning techniques such as support vector machine, random forest, and similarity searching. The results show that CWS-ELM in conjunction with support vector clustering yields the best performance when utilised together with Sokal/Sneath(1) coefficient. Furthermore, ECFP_6 fingerprint presents the best results in our framework compared to the other types of fingerprints, namely ECFP_4, FCFP_4, and FCFP_6. PMID:29652912

Report of chronic myeloid leukemia SMS Medical College Hospital, Jaipur

PubMed Central

Malhotra, Hemant; Sharma, Rajesh; Singh, Yogender; Chaturvedi, Hemant

2013-01-01

This is a retrospective analysis of patients of chronic myeloid leukemia (CML) registered and under treatment at the Leukemia Lymphoma Clinic at the Birla Cancer Center, SMS Medical College Hospital, Jaipur. Approximately, two-thirds of the patients are getting imatinib mesylate (IM) through the Glivec International Patient Assistance Program while the rest are on generic IM. In addition to comparison of hematological and molecular responses in the Glivec versus the genetic group, in this analysis, an attempt is also made to assess the socio-economic (SE) status of the patients and its effect on the response rates. Of the 213 patients studied, most (28.6%) are in the age group between 30 years and 40 years and the mean age of the patients in 39 years, a good decade younger that in the west. There is a suggestion that patients in lower SE class present with higher Sokal scores and with more disease burden. Possibly hematological responses are similar with both Glivec and generic IM. No comment can be made with regards to molecular response between the two groups as a significant number of patients in the Glivec arm (42%) do not have molecular assessment because of economic reasons. CML is a common and challenging disease in the developing world with patients presenting at an earlier age with more advanced disease. SE factors play a significant role in therapy and disease monitoring decision making and may impact on response rates and prognosis. PMID:24516303

Report of chronic myeloid leukemia SMS Medical College Hospital, Jaipur.

PubMed

Malhotra, Hemant; Sharma, Rajesh; Singh, Yogender; Chaturvedi, Hemant

2013-07-01

This is a retrospective analysis of patients of chronic myeloid leukemia (CML) registered and under treatment at the Leukemia Lymphoma Clinic at the Birla Cancer Center, SMS Medical College Hospital, Jaipur. Approximately, two-thirds of the patients are getting imatinib mesylate (IM) through the Glivec International Patient Assistance Program while the rest are on generic IM. In addition to comparison of hematological and molecular responses in the Glivec versus the genetic group, in this analysis, an attempt is also made to assess the socio-economic (SE) status of the patients and its effect on the response rates. Of the 213 patients studied, most (28.6%) are in the age group between 30 years and 40 years and the mean age of the patients in 39 years, a good decade younger that in the west. There is a suggestion that patients in lower SE class present with higher Sokal scores and with more disease burden. Possibly hematological responses are similar with both Glivec and generic IM. No comment can be made with regards to molecular response between the two groups as a significant number of patients in the Glivec arm (42%) do not have molecular assessment because of economic reasons. CML is a common and challenging disease in the developing world with patients presenting at an earlier age with more advanced disease. SE factors play a significant role in therapy and disease monitoring decision making and may impact on response rates and prognosis.

Low educational level but not low income impairs the achievement of cytogenetic remission in chronic myeloid leukemia patients treated with imatinib in Brazil.

PubMed

Rego, Monica Napoleão Fortes; Metze, Konradin; Lorand-Metze, Irene

2015-05-01

In Brazil, imatinib mesylate is supplied as the first-line therapy for chronic myeloid leukemia in the chronic phase through the public universal healthcare program, Sistema Único de Saúde (SUS). We studied the socio-demographic factors that influenced therapy success in a population in the northeast region of Brazil. Patients with chronic myeloid leukemia from the state of Piauí were treated in only one reference center. Diagnosis was based on WHO 2008 criteria. Risk was assessed by Sokal, Hasford and EUTOS scores. Patients received 400 mg imatinib daily. We studied the influence of the following factors on the achievement of complete cytogenetic response within one year of treatment: age, clinical risk category, time interval between diagnosis and the start of imatinib treatment, geographic distance from the patient's home to the hospital, years of formal education and monthly income. Among 103 patients studied, the median age was 42 years; 65% of the patients had 2-9 years of formal education, and the median monthly income was approximately 100 US$. Imatinib was started in the first year after diagnosis (early chronic phase) in 69 patients. After 12 months of treatment, 68 patients had a complete cytogenetic response. The Hasford score, delay to start imatinib and years of formal education influenced the attainment of a complete cytogenetic response, whereas income and the distance from the home to the healthcare facility did not. Patients require additional healthcare information to better understand the importance of long-term oral anticancer treatment and to improve their compliance with the treatment.

Chronic myeloid leukaemia in Spain: Its presentation characteristics have changed. Spanish section of the EUTOS population-based registry.

PubMed

Osorio, S; Casado, L F; Giraldo, P; Maestro, B; Andrade, M; Redondo, S; García-Gutiérrez, V; Ayala, R; Garcia, N; Steegmann, J L

2016-01-01

To provide more reliable data on the epidemiology of chronic myeloid leukaemia (CML) in Spain than are currently available. The EUTOS population-based project of European LeukemiaNet is a population registry of new CML cases in patients 18 years of age or older from 22 European areas. The Spanish section included the autonomous communities of Madrid, Castilla-La Mancha and Aragon, from 1-2-2010 to 31-12-2012. A total of 250 cases were recorded in 35 months. The overall incidence was 1.08 cases/10(5) inhabitants-year, with a predominance of men (58%) and clear differences among the communities. The incidence standardised by age was similar (overall, 1.04; men, 1.31; women, 0.81). The median age was 54 years. The incidence increased with age, reaching a peak at>65 years, although 31.7% of cases appeared between the ages of 20 and 44 years. Four percent of cases were diagnosed in advanced stages (2.4% in accelerated phase, 1.6% in blast crisis), 56% were asymptomatic, 38% had splenomegaly, and the Sokal score was high in 11% (lower than what was previously reflected in the literature). The current incidence of CML in Spain is higher than previously reported and similar to that of the European studies. Unlike the classical descriptions, CML presented mostly in asymptomatic form, with no splenomegaly, less leucocytosis and in stages with better prognosis. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

Real time assessment of the 15 July 2009 New Zealand tsunami

NASA Astrophysics Data System (ADS)

Uslu, Burak; Power, William; Greensdale, Dianne; Titov, Vasily

2010-05-01

On the 15th July 2009 a Mw 7.6 earthquake occurred off the coast of Fiordland in the South Island of New Zealand, about 1200 km from Auckland, New Zealand, 1500 km from Hobart, Tasmania and 1800 km from Sydney, Australia. A tsunami was generated and an initial warning issued by the PTWC. The Centre for Australian Weather and Climate issued its first tsunami warning for coastal regions of eastern Australia and New Zealand 24 minutes after the earthquake. By serendipitous coincidence, the earthquake struck while the International Tsunami Symposium was in session in Novosibirsk Russia. This provided the opportunity to test, in real-time, several tsunami warning systems in front of attending scientists (Schiermeier, 2009). NOAA Center for Tsunami Research, Pacific Tsunami Warning Center, GNS Science, and Centre for Australian Weather and Climate scientists were present at the symposium and worked together. Vasily Titov showed "live" NOAA's methodology (Bernard et al, 2006) to assess the tsunami potential and, in consultation with colleagues, provided warning guidance, and the warning was eventually canceled. We discuss how the forecast was done and how accurate the initial determination was. References Bernard E.N. et al., 2006, Tsunami: scientific frontiers, mitigation, forecasting and policy implications, Phil. Trans. R. Soc. A, 364:1989-2007; doi:10.1098/rsta.2006.1809 Schiermeier, Q., 2009, Tsunami forecast in real time, Published online 16 July 2009 | Nature | doi:10.1038/news.2009.702

Tsunami Forecast Progress Five Years After Indonesian Disaster

NASA Astrophysics Data System (ADS)

Titov, Vasily V.; Bernard, Eddie N.; Weinstein, Stuart A.; Kanoglu, Utku; Synolakis, Costas E.

2010-05-01

Almost five years after the 26 December 2004 Indian Ocean tragedy, tsunami warnings are finally benefiting from decades of research toward effective model-based forecasts. Since the 2004 tsunami, two seminal advances have been (i) deep-ocean tsunami measurements with tsunameters and (ii) their use in accurately forecasting tsunamis after the tsunami has been generated. Using direct measurements of deep-ocean tsunami heights, assimilated into numerical models for specific locations, greatly improves the real-time forecast accuracy over earthquake-derived magnitude estimates of tsunami impact. Since 2003, this method has been used to forecast tsunamis at specific harbors for different events in the Pacific and Indian Oceans. Recent tsunamis illustrated how this technology is being adopted in global tsunami warning operations. The U.S. forecasting system was used by both research and operations to evaluate the tsunami hazard. Tests demonstrated the effectiveness of operational tsunami forecasting using real-time deep-ocean data assimilated into forecast models. Several examples also showed potential of distributed forecast tools. With IOC and USAID funding, NOAA researchers at PMEL developed the Community Model Interface for Tsunami (ComMIT) tool and distributed it through extensive capacity-building sessions in the Indian Ocean. Over hundred scientists have been trained in tsunami inundation mapping, leading to the first generation of inundation models for many Indian Ocean shorelines. These same inundation models can also be used for real-time tsunami forecasts as was demonstrated during several events. Contact Information Vasily V. Titov, Seattle, Washington, USA, 98115

Cessation of tyrosine kinase inhibitors in patients with chronic-phase chronic myelogenous leukemia following durable complete molecular response: a single center facing the dilemma.

PubMed

Iliakis, Theodoros; Papadopoulou, Vasiliki; Diamantopoulos, Panagiotis T; Panayiotidis, Panayiotis; Zervakis, Konstantinos; Giannakopoulou, Nefeli; Tilimidos, Gerassimos; Angelopoulou, Maria; Siakantaris, Marina P; Pangalis, Gerassimos; Mantzourani, Marina; Variami, Eleni; Viniou, Nora Athina

2013-08-01

Tyrosine kinase inhibitors (TKIs), namely imatinib mesylate (IM) and recently approved second-generation TKIs dasatinib and nilotinib, are currently considered the treatment of choice for newly-diagnosed chronic phase chronic myelogenous leukemia (CP-CML). Although treatment with TKIs has not yet been proven curative, it certainly accomplishes a sustained control of the disease in the vast majority of patients. More than a decade after the successful launching of IM in first-line treatment of CP-CML and the subsequent introduction of second-generation TKIs in this setting, the question of the possibility of TKI cessation in a specific subset of patients has emerged. Side-effects of TKIs, along with some patients' wish to abandon the drugs and the rising financial burden upon healthcare systems, have led to the dilemma whether IM can be safely withdrawn after achieving deep molecular remissions and which patients are suitable for this discontinuation. We examined the data of our patients with CML in search of potential canditates for cessation of TKI therapy and identified their characteristics. We also performed a thorough review of the relevant literature. Eight out of fifty patients were discriminated on grounds of sustained complete molecular response (CMR) exceeding 12 months, most of them with a low or intermediate Sokal score at diagnosis. The median interval from IM initiation to CMR was almost 2 years and the median duration of detected CMR reached 6.5 years. Based on the promising results of prospective clinical trials reporting successful cessation of treatment with TKIs on selected subgroups of patients, we decided to proceed to interruption of therapy in the specific subset of our patients and closely monitor their response.

KSC-97PC811

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist Jean-Francois Clervoy prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC807

NASA Image and Video Library

1997-05-15

STS-84 Commander Charles J. Precourt prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC806

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist C. Michael Foale prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC810

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist Carlos I. Noriega prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC808

NASA Image and Video Library

1997-05-15

STS-84 Pilot Eileen M. Collins prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC809

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist Edward T. Lu prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC812

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist Elena V. Kondakova prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

Oral Histories in Meteoritics and Planetary Science - XX: Dale Cruikshank

NASA Astrophysics Data System (ADS)

Sears, Derek W. G.

2013-04-01

In this interview, Dale Cruikshank (Fig. 1) explains how as an undergraduate at Iowa State University he was a summer student at Yerkes Observatory where he assisted Gerard Kuiper in work on his Photographic Lunar Atlas. Upon completing his degree, Dale went to graduate school at the University of Arizona with Kuiper where he worked on the IR spectroscopy of the lunar surface. After an eventful 1968 trip to Moscow via Prague, during which the Soviets invaded Czechoslovakia, Dale assumed a postdoc position with Vasili Moroz at the Sternberg Astronomical Institute and more observational IR astronomy. Upon returning to the United States and after a year at Arizona, Dale assumed a position at the University of Hawai'i that he held for 17 years. During this period Dale worked with others on thermal infrared determinations of the albedos of small bodies beyond the asteroid Main Belt, leading to the recognition that low-albedo material is prevalent in the outer solar system that made the first report of complex organic solids on a planetary body (Saturn's satellite Iapetus). After moving to Ames Research Center, where he works currently, he continued this work and became involved in many outer solar system missions. Dale has served the community through his involvement in developing national policies for science-driven planetary exploration, being chair of the DPS 1990-1991 and secretary/treasurer for 1982-1985. He served as president of Commission 16 (Physics of Planets) of the IAU (2001-2003). He received the Kuiper prize in 2006.

Durable treatment-free remission in patients with chronic myeloid leukemia in chronic phase following frontline nilotinib: 96-week update of the ENESTfreedom study.

PubMed

Ross, David M; Masszi, Tamas; Gómez Casares, María Teresa; Hellmann, Andrzej; Stentoft, Jesper; Conneally, Eibhlin; Garcia-Gutierrez, Valentin; Gattermann, Norbert; le Coutre, Philipp D; Martino, Bruno; Saussele, Susanne; Giles, Francis J; Radich, Jerald P; Saglio, Giuseppe; Deng, Weiping; Krunic, Nancy; Bédoucha, Véronique; Gopalakrishna, Prashanth; Hochhaus, Andreas

2018-05-01

ENESTfreedom is evaluating treatment-free remission (TFR) following frontline nilotinib in patients with chronic myeloid leukemia (CML) in chronic phase. Following our primary analysis at 48 weeks, we here provide an updated 96-week analysis. Attempting TFR required ≥ 3 years of nilotinib, a molecular response of MR 4.5 [BCR-ABL1 ≤ 0.0032% on the International Scale (BCR-ABL1 IS )], and sustained deep molecular response (DMR) during a 1-year consolidation phase. Patients restarted nilotinib following loss of major molecular response (MMR; BCR-ABL1 IS  ≤ 0.1%). Ninety-six weeks after stopping treatment (3.6-year median prior nilotinib duration), 93 of 190 patients (48.9%) remained in TFR. Of 88 patients who restarted nilotinib following loss of MMR, 87 regained MMR and 81 regained MR 4.5 by the data cut-off. Ninety-six-week TFR rates were 61.3, 50.0, and 28.6% in patients with low, intermediate, and high Sokal risk scores at diagnosis, respectively. Patients consistently in MR 4.5 during consolidation had higher TFR rates (50.6%) than patients with ≥ 1 assessment without MR 4.5 during consolidation (35.0%). In a landmark analysis, 96-week TFR rates for patients with MR 4.5 , MR 4 (BCR-ABL1 IS  ≤ 0.01%) but not MR 4.5 , and MMR but not MR 4 at TFR week 12 were 82.6, 23.1, and 0%, respectively. There were no reports of disease progression or death due to CML; overall adverse event frequency decreased following TFR. Within the follow-up period, TFR did not adversely affect disease outcomes. These results demonstrate the feasibility and durability of TFR following frontline nilotinib and emphasize the importance of sustained DMR for TFR.

Reduced-intensity allogeneic hematopoietic stem cell transplantation combined with imatinib has comparable event-free survival and overall survival to long-term imatinib treatment in young patients with chronic myeloid leukemia.

PubMed

Zhao, Yanmin; Wang, Jiasheng; Luo, Yi; Shi, Jimin; Zheng, Weiyan; Tan, Yamin; Cai, Zhen; Huang, He

2017-08-01

The relative merits of reduced intensity hematopoietic stem cell transplantation (RIST) for chronic myeloid leukemia (CML) in the first chronic phase (CP) in imatinib era have not been evaluated. The study was designed to compare the outcomes of combination therapy of RIST plus imatinib (RIST + IM) vs. imatinib (IM) alone for young patients with early CP (ECP) and late CP (LCP). Of the patients, 130 were non-randomly assigned to treatment with IM alone (n = 88) or RIST + IM (n = 42). The 10-year overall survival (OS) and event-free survival (EFS) were comparable between RIST + IM and IM groups. LCP, high Sokal score, and no complete cytogenetic response at 3 months were adverse prognostic factors for survival, but only the time from diagnosis to IM was an independent predictor after multivariate analysis. For ECP, IM was similar to RIST + IM, with 10-year EFS rates of 77.2 vs. 81.6% (p = 0.876) and OS rates of 93.8 vs. 87.9% (p = 0.102), respectively. For LCP, both treatments resulted in similar survival, but more patients in the imatinib group experienced events (10-year EFS 40.8 vs. 66.7%, p = 0.047). The patients with higher EBMT risk scores had an inferior survival than those with lower scores (69.2 vs. 92.9%, p = 0.04). We concluded that RIST + IM was comparable to IM in terms of OS and EFS. However, RIST + IM was more affordable than IM alone in a 10-year scale. Thus, RIST + IM could be considered as an alternative treatment option, especially when the patients have low EBMT risk scores and demand a definite cure for CML.

Outcomes of Chronic Myeloid Leukemia Patients With Early Molecular Response at 3 and 6 Months: A Comparative Analysis of Generic Imatinib and Glivec.

PubMed

Eskazan, Ahmet Emre; Sadri, Sevil; Keskin, Dilek; Ayer, Mesut; Kantarcioglu, Bulent; Demirel, Naciye; Aydin, Demet; Aydinli, Fuat; Yokus, Osman; Ozunal, Isil Erdogan; Berk, Selin; Yalniz, Fevzi Firat; Elverdi, Tugrul; Salihoglu, Ayse; Ar, Muhlis Cem; Ongoren, Seniz; Baslar, Zafer; Aydin, Yildiz; Tuzuner, Nukhet; Ozbek, Ugur; Soysal, Teoman

2017-12-01

The molecular response at 3 months of the original imatinib (OI) in patients with chronic myeloid leukemia has prognostic significance; however, this has never been tested for generic imatinib (GI). We evaluated the BCR-ABL1 [international reporting scale (IS)] transcript levels at 3 and 6 months to determine whether an early molecular response (EMR) had a prognostic effect on the outcome among chronic myeloid leukemia patients receiving GI. Ninety patients were divided into 2 groups, according to the imatinib they received, as OI (group A) and GI (group B). Two groups were equally balanced for age, gender, Sokal risk score, and optimal response. The 2 groups did not differ in achieving an EMR at 3 months, and patients with EMR at 3 months had significantly superior complete cytogenetic response and major molecular response rates compared with patients who did not achieve an EMR in both groups. The percentage of an optimal response [BCR-ABL1 (IS), < 1%] and a warning response [BCR-ABL1 (IS), 1%-10%] at 6 months was 93% and 95% for groups A and B, respectively (P = .553). Patients with an optimal response (OR) at both 3 and 6 months had significantly superior event-free survival rates compared with patients without an OR in groups A and B. The results of the present study have demonstrated most probably for the first time that an OR at 3 and 6 months in patients receiving either first-line GI and OI is clearly associated with greater response and event-free survival rates. Prospective randomized trials with larger numbers of patients and longer follow-up periods are needed to address the effect of EMR in patients receiving GI. Copyright © 2017 Elsevier Inc. All rights reserved.

Dasatinib first-line: Multicentric Italian experience outside clinical trials.

PubMed

Breccia, Massimo; Stagno, Fabio; Luciano, Luigiana; Abruzzese, Elisabetta; Annunziata, Mario; D'Adda, Mariella; Maggi, Alessandro; Sgherza, Nicola; Russo-Rossi, Antonella; Pregno, Patrizia; Castagnetti, Fausto; Iurlo, Alessandra; Latagliata, Roberto; Cedrone, Michele; Di Renzo, Nicola; Sorà, Federica; Rege-Cambrin, Giovanna; La Nasa, Giorgio; Scortechini, Anna Rita; Greco, Giovanna; Franceschini, Luca; Sica, Simona; Bocchia, Monica; Crugnola, Monica; Orlandi, Esther; Guarini, Attilio; Specchia, Giorgina; Rosti, Gianantonio; Saglio, Giuseppe; Alimena, Giuliana

2016-01-01

Dasatinib was approved for the treatment of chronic phase (CP) chronic myeloid leukemia (CML) patients in first line therapy based on the demonstration of efficacy and safety reported in patients enrolled in clinical trials. We describe a multicentric Italian "real-life" experience of dasatinib used as frontline treatment outside clinical trials. One hundred and nine patients (median age 54 years) were treated from January 2012 to December 2013. Increased incidence of high risk patients were detected according to stratification (26% according to Sokal score, 19% according to Euro score and 16% according to EUTOS) when compared to company sponsored studies. Median time from diagnosis to start of dasatinib was 18 days. Ten patients received unscheduled starting dose (6 patients 50mg and 4 patients 80 mg QD), whereas 99 patients started with 100mg QD. At 3 months, 92% of patients achieved a BCR-ABL ratio less than 10%. At 6 months, the rate of CCyR was 91% and the rate of MR3 was 40%, with 8% of the patients reaching MR4.5. Ninety-three patients were evaluable at 12 months: the rate of MR3 was 62%, with MR4.5 being achieved by 19% of the patients. At a median follow-up of 12 months, 27 patients (24.7%) were receiving the drug at reduced dose. Two patients (1.8%) experienced a lymphoid blast crisis and the overall incidence of resistance was 8%. As regards safety, the major side effects recorded were thrombocytopenia, neutropenia and pleural effusions, which occurred in 22%, 10% and 8% of patients, respectively. Present results, achieved in a large cohort of patients treated outside clinical trials, further confirm the efficacy and safety of dasatinib as firstline treatment in CML. Copyright © 2015 Elsevier Ltd. All rights reserved.

STS-84 Commander Charles J. Precourt in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Commander Charles J. Precourt prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

Atlantis lifts off on mission STS-84

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC803

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Mission Specialist C. Michael Foale in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist C. Michael Foale prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Pilot Eileen Marie Collins in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Pilot Eileen M. Collins prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC800

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC802

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Mission Specialist Jean-Francois Clervoy in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Jean- Francois Clervoy prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Mission Specialist Edward Tsang Lu in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Edward T. Lu prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC804

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Liftoff (across water)

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Mission Specialist Elena V. Kondakova in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Elena V. Kondakova prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC801

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Mission Specialist Carlos I. Noriega in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Carlos I. Noriega prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Shuttle Atlantis Liftoff

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC805

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC799

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC798

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Night Launch (left view)

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Night Launch (front view)

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Night Launch (side view)

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

Mitochondrial pathogenic mutations are population-specific.

PubMed

Breen, Michael S; Kondrashov, Fyodor A

2010-12-31

to improve the diagnostics of individuals carrying African mitochondrial haplotypes, it is necessary to survey different populations independently. This article was reviewed by Dr Mikhail Gelfand, Dr Vasily Ramensky (nominated by Dr Eugene Koonin) and Dr David Rand (nominated by Dr Laurence Hurst).

PREFACE: 2nd International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research''

NASA Astrophysics Data System (ADS)

Naumova, A. V.; Khodanovich, M. Y.; Yarnykh, V. L.

2016-02-01

The Second International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research'' was held on the campus of the National Research Tomsk State University (Tomsk, Russia) on September 7-9, 2015. The conference was focused on magnetic resonance imaging (MRI) applications for biomedical research. The main goal was to bring together basic scientists, clinical researchers and developers of new MRI techniques to bridge the gap between clinical/research needs and advanced technological solutions. The conference fostered research and development in basic and clinical MR science and its application to health care. It also had an educational purpose to promote understanding of cutting-edge MR developments. The conference provided an opportunity for researchers and clinicians to present their recent theoretical developments, practical applications, and to discuss unsolved problems. The program of the conference was divided into three main topics. First day of the conference was devoted to educational lectures on the fundamentals of MRI physics and image acquisition/reconstruction techniques, including recent developments in quantitative MRI. The second day was focused on developments and applications of new contrast agents. Multinuclear and spectroscopic acquisitions as well as functional MRI were presented during the third day of the conference. We would like to highlight the main developments presented at the conference and introduce the prominent speakers. The keynote speaker of the conference Dr. Vasily Yarnykh (University of Washington, Seattle, USA) presented a recently developed MRI method, macromolecular proton fraction (MPF) mapping, as a unique tool for modifying image contrast and a unique tool for quantification of the myelin content in neural tissues. Professor Yury Pirogov (Lomonosov Moscow State University) described development of new fluorocarbon compounds and applications for biomedicine. Drs. Julia Velikina and Alexey

Gender and ethnic differences in chronic myelogenous leukemia prognosis and treatment response: a single-institution retrospective study

PubMed Central

Lee, Justin P; Birnstein, Elliott; Masiello, David; Yang, Dongyun; Yang, Allen S

2009-01-01

Background In the last decade the importance of ethnicity, socio-economic and gender differences in relation to disease incidence, diagnosis, and prognosis has been realized. Differences in these areas have become a major health policy focus in the United States. Our study was undertaken to examine the demographic and clinical features of chronic myelogenous leukemia (CML) patients presenting initially at the LAC+USC Medical Center, which serves an ethnically diverse population. Results Patients were evenly split by gender, overwhelmingly Hispanic (60.9%), and quite young (median age 39, range 17–65) compared with previously reported CML patient populations. Previous CML studies identified significant anemia (Hgb <12 g/dl), significant thrombocytosis (platelets >450 × 109/l), and significant leukocytosis (WBC >50 × 109/l) as significant adverse pretreatment prognostic factors. Using these indicators, in addition to the validated Hasford and Sokal scores, patients were stratified and analyzed via gender and ethnicity. A significantly greater proportion of women presented with significant anemia (p = 0.019, Fisher's exact test) and significant thrombocytosis (p = 0.041, Fisher's exact test) compared to men, although no differences were found in risk stratification or treatment response. MCV values for women were significantly (p = 0.02, 2-sample t-test) lower than those for men, suggesting iron deficiency anemia. Focusing on ethnicity, Hispanics as a whole had significantly lower Hasford risk stratification (p = 0.046, Fisher's exact test), and significantly greater likelihood (p = 0.016, Fisher's exact test) of achieving 3-month complete haematological remission (CHR) compared with non-Hispanics at LAC+USC Medical Center, though differences in treatment outcome were no longer significant with analysis limited to patients treated with first-line imatinib. Conclusion Female CML patients at LAC+USC Medical Center present with more significant adverse pre

Analytical solution for tension-saturated and unsaturated flow from wicking porous pipes in subsurface irrigation: The Kornev-Philip legacies revisited

NASA Astrophysics Data System (ADS)

Kacimov, A. R.; Obnosov, Yu. V.

2017-03-01

" roots just in "right quantities", spontaneously and continuously, i.e. without any electronic or mechanical controls. Almost a century ago the Russian engineer Vasily Kornev designed and tested this "smart watering" technology in France and USSR. Later, the Australian soil physicist John Philip developed mathematical models which predicted how much water is emitted from a porous pipe and how this moisture is distributed in the near-emitter soil. We develop further Philip's theory and match it with Kornev's farmers-level design and irrigation practices. Namely, we predict how the pipe wall properties and negative water pressure in porous pipes are controlling soil water conditions.

Outcome of Frontline Treatment with "Generic" Imatinib In Adult Patients with Chronic Myeloid Leukemia in Algerian Population: A Multicenter Study.

PubMed

Entasoltan, B; Bekadja, M A; Touhami, H; Mehalhal, N; Zouaoui, Z; Mesli, N; Talbi, M; Bachiri, A; Michallet, M

2017-01-01

In a developing country like Algeria, such expensive therapy is not available. Alternative approaches are needed to help these adult. In Algeria 'imatib' (CIPLA-India) was introduced in 2006; but no study has been published yet in the North Africa region regarding response and outcome of this copy in CML patients. The goal of this multicenter study is to characterize newly adult CML in the western region of Algeria and to assess the effectiveness and safety of imatib (IM, copy) as frontline therapy for patients with CML. The study was carried out in 7 hematology centers in the western Algeria. Patients, who were diagnosed to be suffering from CML between January 1st, 2007 and December 31st, 2014 were selected for data analysis. All patients received a copy preparation, consisting of the alpha crystal form of imatinib, (IM, copy) at an oral dose of 400 mg daily and monitored for tolerance and side effects while on therapy. Between January 2007 and December 2014, 355 patients with CML were treated with imatib (Copy). The median follow- up of the study was 46 months (range: 13-107 months). Complete hematological response (CHR) was seen in 83% of patients within 3 months. According to the Sokal score, 72% patients with low, 78% with intermediate and 69% with high risk disease achieved a CHR in 3 months (p=0.26) and according to the EUTOS score, 81% of patients with low and 70% with high risk disease achieved a CHR in 3 months (p=0.08). The major molecular response (MMR) at six months (M6), M9, M12, M18 and M24 was 21%, 38%, 35%, 51% and 67% respectively and 34% of patients achieved a complete molecular response (CMR). The projected 5-year overall survival (OS) rate was 83%. Side effects of imatib (copy) in this study were similar to those reported previously for the entire imatinib mesylate treatment study and only 8% of patients were intolerant to imatib (copy) and treated with a second generation of BCR-ABL inhibitor. This study reflects real world experience

Diagnosis and Monitoring of Chronic Myeloid Leukemia: Chiang Mai University Experience.

PubMed

Tantiworawit, Adisak; Kongjarern, Supanat; Rattarittamrong, Ekarat; Lekawanvijit, Suree; Bumroongkit, Kanokkan; Boonma, Nonglak; Rattanathammethee, Thanawat; Hantrakool, Sasinee; Chai-Adisaksopha, Chatree; Norasetthada, Lalita

2016-01-01

A diagnosis of chronic myeloid leukemia (CML) is made on discovery of the presence of a Philadelphia (Ph) chromosome. The success of the treatment of this form of leukemia with tyrosine kinase inhibitor (TKI) is monitored by reduction of the Ph chromosome. To compare the role of conventional cytogenetic (CC) methods with a real time quantitative polymerase chain reaction (RQ-PCR) and fluorescence in situ hybridization (FISH) for diagnosis and treatment monitoring of CML patients. The secondary outcome was to analyze the treatment responses to TKI in CML patients. This was a retrospective study of CML patients who attended the Hematology clinic at Chiang Mai University Hospital from 2005-2010. Medical records were reviewed for demographic data, risk score, treatment response and the results of CC methods, FISH and RQ-PCR. One hundred and twenty three cases were included in the study, 57.7% of whom were male with a mean age of 46.9 years. Most of the patients registered as intermediate to high risk on the Sokal score. At diagnosis, 121 patients were tested using the CC method and 118 (95.9%) were identified as positive. Five patients failed to be diagnosed by CC methods but were positive for BCR-ABL1 using the FISH method. Imatinib was the first-line treatment used in 120 patients (97.6%). In most patients (108 out of 122, 88.5%), a complete cytogenetic response (CCyR) was achieved after TKI therapy and in 86 patients (70.5%) CCyR was achieved long term by the CC method. Five out of the 35 analyzed patients in which CCyR was achieved by the CC method had a positive FISH result. Out of the 76 patients in which CCyR was achieved, RQ-PCR classified patients to only CCyR in 17 patients (22.4%) with a deeper major molecular response (MMR) in 4 patients (5.3%) and complete molecular response (CMR) in 55 patients (72.4%). In the case of initial therapy, CCyR was achieved in 95 patients (79.1%) who received imatinib and in both patients who received dasatinib (100%). For the

Non-Invasive Assessment of Susceptibility to Ventricular Arrhythmias During Simulated Microgravity

NASA Technical Reports Server (NTRS)

Cohen, Richard J.

1999-01-01

The Cardiovascular Alterations Team is currently conducting studies to determine what alterations in hemodynamic regulation result from sixteen days of simulated microgravity exposure in normal human subjects. In this project we make additional measurements on these same study subjects in order to determine whether there is an increase in susceptibility to ventricular arrhythmias resulting from simulated microgravity exposure. Numerous anecdotal and documented reports from the past 30 years suggest that the incidence of ventricular arrhythmias among astronauts is increased during space flight. For example, documented runs of ventricular tachycardia have been recorded from crew members of Skylab and Mir, there was much attention given by the lay press to Mir Commander Vasily Tslbliyev's complaints of heart rhythm irregularities in July of 1997, and cardiovascular mechanisms may have been causal in the recent death of an experimental primate shortly after return from space. In 1986, a Mir cosmonaut, Alexander Laveikin, was brought home and replaced with an alternate cosmonaut as a result of cardiac dysrhythmias that began during extravehicular activity. Furthermore, at a joint NASA/NSBRI workshop held in January 1998, cardiac arrhythmias were identified as the highest priority cardiovascular risk to a human Mars mission. Despite the evidence for the risk of a potentially lethal arrhythmia resulting from microgravity exposure, the effects of space flight and the associated physiologic stresses on cardiac conduction processes are not known, and an increase in cardiac susceptibility to arrhythmias has never been quantified. In this project, we are determining whether simulated space flight increases the risk of developing life-threatening heart rhythm disturbances such as sustained ventricular tachycardia (defined as ventricular tachycardia lasting at least 30 seconds or resulting in hemodynamic collapse) and ventricular fibrillation. We are obtaining measures of

Density of states, Potts zeros, and Fisher zeros of the Q

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Seung-Yeon; Creswick, Richard J.

2001-06-01

that y{sub t} is a smooth function of Q and is well fitted by y{sub t}=(1+Au+Bu{sup 2})/(C+Du) where u={minus}(2/{pi})cos{sup {minus}1}({radical}Q/2). For Q=3 we find y{sub t}{approx_equal}0.6; however if we include lattices up to L=12 we find y{sub t}{approx_equal}0.50(8) in rough agreement with a recent result of Ferreira and Sokal [J. Stat. Phys. >96, 461 (1999)].« less

Deep Ocean Tsunami Waves off the Sri Lankan Coast

NASA Technical Reports Server (NTRS)

2004-01-01

fully understand the dynamics. Examination of other MISR images of this area, taken under similar illumination conditions, has not uncovered any surface patterns resembling those seen here. This image is an example of how MISR's multi-angular capability provides unique information for understanding how tsunamis propagate. Another application of MISR data enabled scientists to measure the motion of breaking tsunami waves along the eastern shores of Andhra Pradesh, India. The Multi-angle Imaging SpectroRadiometer observes the daylit Earth continuously and every 9 days views the entire globe between 82 degrees North and 82 degrees South latitude. These data products were generated from a portion of the imagery acquired during Terra orbit 26720 and utilize data from within blocks 85 to 86 within World Reference System-2 path 142. MISR was built and is managed by NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Office of Earth Science, Washington, DC. The Terra satellite is managed by NASA's Goddard Space Flight Center, Greenbelt, MD. Image courtesy NASA/GSFC/LaRC/JPL, MISR Team. Text by Clare Averill (Raytheon ITSS/JPL); Michael Garay and David J. Diner (JPL, California Institute of Technology); and Vasily Titov (NOAA/Pacific Marine Environmental Laboratory and University of Washington/Joint Institute for the Study of the Atmosphere and Oceans).

Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial.

PubMed

Lipton, Jeffrey H; Chuah, Charles; Guerci-Bresler, Agnès; Rosti, Gianantonio; Simpson, David; Assouline, Sarit; Etienne, Gabriel; Nicolini, Franck E; le Coutre, Philipp; Clark, Richard E; Stenke, Leif; Andorsky, David; Oehler, Vivian; Lustgarten, Stephanie; Rivera, Victor M; Clackson, Timothy; Haluska, Frank G; Baccarani, Michele; Cortes, Jorge E; Guilhot, François; Hochhaus, Andreas; Hughes, Timothy; Kantarjian, Hagop M; Shah, Neil P; Talpaz, Moshe; Deininger, Michael W

2016-05-01

Ponatinib has shown potent activity against chronic myeloid leukaemia that is resistant to available treatment, although it is associated with arterial occlusion. We investigated whether this activity and safety profile would result in superior outcomes compared with imatinib in previously untreated patients with chronic myeloid leukaemia. The Evaluation of Ponatinib versus Imatinib in Chronic Myeloid Leukemia (EPIC) study was a randomised, open-label, phase 3 trial designed to assess the efficacy and safety of ponatinib, compared with imatinib, in newly diagnosed patients with chronic-phase chronic myeloid leukaemia. Patients from 106 centres in 21 countries were randomly assigned (1:1, with stratification by Sokal score at diagnosis) using an interactive voice and web response system to receive oral ponatinib (45 mg) or imatinib (400 mg) once daily until progression, unacceptable toxicity, or other criteria for withdrawal were met. Eligible patients were at least 18 years of age, within 6 months of diagnosis, and Philadelphia chromosome-positive by cytogenetic assessment, with Eastern Cooperative Oncology Group performance status of 0-2, and had not previously been treated with tyrosine kinase inhibitors. The primary endpoint was major molecular response at 12 months. Patients who remained on study and had molecular assessments at specified timepoints were studied at those timepoints. Safety analyses included all treated patients, as per study protocol. This trial is registered with ClinicalTrials.gov, number NCT01650805. Between Aug 14, 2012, and Oct 9, 2013, 307 patients were randomly assigned to receive ponatinib (n=155) or imatinib (n=152). The trial was terminated early, on Oct 17, 2013, following concerns about vascular adverse events observed in patients given ponatinib in other trials. Trial termination limited assessment of the primary endpoint of major molecular response at 12 months, as only 13 patients in the imatinib group and ten patients in the

Electrochemical oxygen pumps. Final CRADA report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carter, J. D.

2009-10-01

Vasily Lepalovsky; and Translator Vladimir Litvinov. During this trip project participants were to discuss with the project Technical Monitor J.D. Carter and representative of Praxair Inc. J. Chen the results of project activities (prospects of transition metal-doped material application in oxygen pumps), as well as the prospects of cooperation with Praxair at the meeting with the company management in the following fields: (1) Deposition of thin films of oxide materials of complex composition on support by magnetron and ion sputtering, research of coatings properties; (2) Development of block-type structure technology (made of porous and dense ceramics) for oxygen pump. The block-type structure is promising because when the size of electrolyte block is 2 x 2 inches and assembly height is 10 inches (5 blocks connected together) the area of active surface is ca. 290 square inches (in case of 8 slots), that roughly corresponds to one tube with diameter 1 inch and height 100 inches. So performance of the system made of such blocks may be by a factor of two or three higher than that of tube-based system. However one month before the visit, J. Chen notified us of internal changes at Praxair and the cancellation of the visit to Tonawanda, NY. During consultations with the project Technical Monitor J.D. Carter and Senior Project Manager A. Taylor a decision was made to extend the project term by 2 quarters to prepare proposals for follow-on activities during this extension (development of block-type structures made of dense and porous oxide ceramics for electrochemical oxygen pumps) using the funds that were not used for the trip to the US.« less

New method to determine initial surface water displacement at tsunami source

NASA Astrophysics Data System (ADS)

Lavrentyev, Mikhail; Romanenko, Alexey; Tatarintsev, Pavel

2013-04-01

earthquake. However, today it is not yet possible. Ground-based sea radars. This is an effective tool for direct measurement of tsunami wave. At the same time, the wave is measured at a rather narrow area in front of the radar and does not include information about neighboring parts of the wave. Direct measurement of tsunami wave at deep water [2]. Today, this technology is certainly among the most useful and promising. The DART II® system consists of a seafloor bottom pressure recording (BPR) system, capable of detecting tsunamis as small as 1 cm, and a moored surface buoy for real-time communications. We focus our research on improving the later method, direct measurement of tsunami wave at deep water. We suggest the new way to analyze DART data, modifying the methodology originally proposed by V. Titov. Smaller system of unit sources [3] should be considered to approximate all typical shapes of initial disturbance by several suitable basis functions. To successfully implement it, performance of data analysis should be dramatically improved. This could be done by using a signal orthogonalization procedure for considered system of unit sources and calculation of Fourier coefficients of the measured time series with respect to orthogonal basis. The approach suggested was used as a part of computerized workstation for tsunami hazard monitoring [5-6]. National Oceanic and Atmospheric Administration Center for Tsunami Research. URL: http://nctr.pmel.noaa.gov/honshu20110311/ National Data Buoy Center. URL: http://www.ndbc.noaa.gov/dart.shtml National Oceanic and Atmospheric Administration Center for Tsunami Research. URL: http://sift.pmel.noaa.gov/thredds/dodsC/uncompressed/ National Oceanic and Atmospheric Administration Center for Tsunami Research. URL: http://nctr.pmel.noaa.gov/model.html Alexey Romanenko, Mikhail Lavrentiev-jr, Vasily Titov, "Modern Architecture for Tsunami Hazard Mitigation" // Asia Oceania Geosciences Society (AOGS-2012), ISBN 978-981-07-2049-0 Mikhail

Interglacial-glacial cycles recorded in the deposit sequence at Kruzhyky on the Dniester River (East Carpathian Foreland)

NASA Astrophysics Data System (ADS)

Łanczont, Maria; Boguckyj, Aandrij; Mroczek, Przemysław; Zieliński, Paweł; Jacyszyn, Andrij; Pidek, Agnieszka I.; Urban, Danuta; Kulesza, Piotr; Hołub, Beata

2010-01-01

of sands with horizontal stratification and silts with horizontal or flaser lamination; single small-scale lithofacies of sands with trough cross-stratification occur in places; single gravel grains are numerous. Two deformation horizons are found: the higher one is characterized by the occurrence of folds and flexure deflections, and the lower one-involution structures and casts of ice wedges/fissures. This complex is probably the result of deposition on the distal part of flat, periodically inundated fluvioglacial fan connected with advancing ice sheet. 4. Ablation complex-sandy or sandy-silty diamicton occurring as isolated inserts, lenses or tongues. Its lower boundary is sharp, erosional and uneven (concave). This complex represents flows of supraglacial tills, which strongly deformed the deposits of the underlying complex 3. 5. Aeolian complex-silty (loess) and sandy-silty (Table 1) deposits with distinct traces of intensive, postsedimentary alterations of pedogenesis of different ages (Tables 1 and 2). It is composed of two soil units separated by thin, primary loess layer: a) older, well-developed paleosol with several pedofeatures very typical of the Sokal (Mazovian) soil; b) younger unit developed as pedocomplex consisting of two mature soils, the upper of which ("modern" neosol) is formed in the top of relict and exhumed paleosol. The described paleosols should be recognized as at least two soils of different ages and of interglacial rank, developed in periglacial loess-like deposits. The Kruzhyky profile is unique in the Dniester River valley. On account of its situation, it supplements the former information about the terrace 5 structure, which has been determined in detail in the Halyč site. And what is most important, it is the only site on the terrace 5 where glacial deposits were found. Lithofacial analysis carried out in the profile enables us to reconstruct the following events reflecting interglacial-glacial cycles: 1. The lowest, gravelly

PREFACE: Rusnanotech 2010 International Forum on Nanotechnology

NASA Astrophysics Data System (ADS)

Kazaryan, Konstantin

2011-03-01

Deputy Director, Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, RussiaProf Vladimir Kvardakov, Corresponding Member of Russian Academy of SciencesExecutive Director, Kurchatov Center of Synchrotron Radiation and Nanotechnology, RussiaProf Edward Son, Corresponding member of Russian Academy of SciencesScientific Deputy Director, Joint Institute for High Temperatures, Russian Academy of Sciences, RussiaProf Andrey GudkovSenior Vice President, Basic Science Chairman, Department of Cell Stress Biology, Roswell Park Cancer Institute, USAProf Robert NemanichChair, Department of Physics, Arizona State University, USAProf Kandlikar SatishProfessor, Rochester Institute of Technology, USAProf Xiang ZhangUC Berkeley, Director of NSF Nano-scale Science and Engineering Center (NSEC), USAProf Andrei ZvyaginProfessor, Macquarie University, AustraliaProf Sergey KalyuzhnyDirector of the Scientific and Technological Expertise Department, RUSNANO, RussiaKonstantin Kazaryan, PhDExpert of the Scientific and Technological Expertise Department, RUSNANO, Russia, Program Committee SecretarySimeon ZhavoronkovHead of Nanotechnology Programs Development Office, Rusnanotech Forum Fund for the Nanotechnology Development, Russia Editors of the proceedings: Section "Nanoelectronics" - Corresponding Member of Russian Academy of Sciences, Professor Anatoly Dvurechenskii (Institute of Semiconductor Physics, RAS).Section "Nanophotonics" - Professor Vasily Klimov (Institute of Physics, RAS).Section "Nanodiagnostics" - Professor P Kashkarov (Russian Scientific Center, Kurchatov Institute).Section "Nanotechnology for power engineering" - Corresponding Member of Russian Academy of Sciences, Professor Eduard Son (Joint Institute for High Temperatures, RAS).Section "Catalysis and chemical industry" - Member of Russian Academy of Sciences, Professor Valentin Parmon (Institute of Catalysis SB RAS).Section "Nanomaterials" - E Obraztsova, PhD (Institute of Physics, RAS), Marat Gallamov Ph

EDITORIAL: Focus on Cloaking and Transformation Optics

NASA Astrophysics Data System (ADS)

Leonhardt, Ulf; Smith, David R.

2008-11-01

coordinate transformations. If the coordinates they conjure up run backwards one gets negative refraction, if they exclude some region of space one makes anything inside invisible [4]. In physics, general relativity has honed the theoretical tools for understanding curved space and curved-coordinate transformations. In transformation optics, general relativity has become a theoretical tool for solving practical engineering problems [4]. What an unorthodox connection! This focus issue represents a snapshot of this rapidly developing research area. It is not restricted to optics or electromagnetism, though. Metamaterials for acoustics also exist and can be applied in ways similar to optical metamaterials. So transformation optics not only attracts an unusual mix of scientists, but also spans a range of applications in optics and beyond. Transformation optics has the potential to transform optics, for example by visualizing invisibility and making materials beyond materials—metamaterials. But before we transgress the boundaries to the hermeneutics of transformation optics [5], let the papers speak for themselves. References [1] Yao J, Liu Z, Liu Y, Wang Y, Sun C, Bartal G, Stacy A M and Zhang X 2008 Science 321 930 [2] Valentine J, Zhang S, Zentgraf T, Ulin-Avila E, Genov D A, Bartal G and Zhang X 2008 Nature 455 376 [3] Schurig D, Mock J J, Justice B J, Cummer S A, Pendry J B, Starr A F and Smith D R 2006 Science 314 977 [4] Leonhardt U and Philbin T G 2006 New J. Phys. 8 247 [5] Sokal A D 1996 Social Text 14(46/47) 217 Focus on Cloaking and Transformation Optics Contents Transformation optics for the full dielectric electromagnetic cloak and metal-dielectric planar hyperlens D P Gaillot, C Croënne, F Zhang and D Lippens Transmutation of singularities in optical instruments Tomáš Tyc and Ulf Leonhardt Electromagnetic cloaking with canonical spiral inclusions K Guven, E Saenz, R Gonzalo, E Ozbay and S Tretyakov Theory and potentials of multi-layered plasmonic covers for

List of Participants

NASA Astrophysics Data System (ADS)

2007-11-01

Physique Théorique, École Polytechnique, Palaiseau Diego Mansi Università Degli Studi di Milano Matteo Marescotti Università del Piemonte Orientale, Alessandria Alberto Mariotti Università di Milano-Bicocca Raffaele Marotta Istituto Nazionale di Fisica Nucleare, Napoli Alessio Marrani Istituto Nazionale di Fisica Nucleare and LNF, Firenze Luca Martucci Instituto de Física Teórica, Madrid and Katholieke Universiteit Leuven David Mateos University of California, Santa Barbara Andrea Mauri Università di Milano Liuba Mazzanti Università di Milano-Bicocca Patrick Meessen Instituto de Física Teórica, Universidad Autónoma de Madrid Lotta Mether Helsinki Institute of Physics Rene Meyer Max-Planck-Institut für Physik, München Giuseppe Milanesi SISSA, Trieste Cesar Miquel-Espanya Universitat de Valencia and Instituto de Física Corpuscular, Valencia Alexander Monin Institute for Theoretical and Experimental Physics (ITEP), Moscow and Moscow State University (MSU) Samuel Monnier Université de Genève Sergio Montero Instituto de Física Teórica, Madrid Nicola Mori Università di Firenze Alexander Marcel Morisse University of California, Santa Cruz Sebastian Moster Max-Planck-Institut für Physik, München Adele Nasti Queen Mary, University of London Vasilis Niarchos École Polytechnique, Palaiseau Emil Nissimov Institute for Nuclear Research and Nuclear Energy, Sofia Francesco Nitti École Polytechnique, Palaiseau Eoin O'Colgain Imperial College, London Niels Obers Niels Bohr Institute, København Rodrigo Olea Università Degli Studi di Milano Marta Orselli Niels Bohr Institute, København Enrico PajerLudwig-Maximilians-Universität, München Eran PaltiOxford University Georgios PapathanasiouBrown University, Providence, RI Angel ParedesCentre de Physique Théorique, École Polytechnique, Palaiseau Jeong-Hyuck ParkMax-Planck-Institut für Physik, München Sara PasquettiUniversità di Parma Silvia PenatiUniversità di Milano-Bicocca Igor PesandoUniversità di Torino