Science.gov

Sample records for species file nos

  1. 78 FR 32622 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... National Oceanic and Atmospheric Administration RIN 0648-XC703 Endangered Species; File Nos. 17557 and... National Ocean Service Marine Forensic Lab (NOS Lab) , 219 Fort Johnson Road, Charleston, SC 29412 (File No... Colligan], 1 Blackburn Drive, Gloucester, MA 01930 (File No. 17273), have applied in due form for...

  2. 77 FR 67631 - Endangered Species; File Nos. 17367 and 17364

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... species recovery in four facilities in the Southeast Region of the USFWS. Research would include nutrition... National Oceanic and Atmospheric Administration RIN 0648-XC348 Endangered Species; File Nos. 17367 and... of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the...

  3. 76 FR 15300 - Endangered Species; File Nos. 16266 and 16291

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... from the NMFS recovery plan outline for this species. The permits would not authorize any takes from... National Oceanic and Atmospheric Administration RIN 0648-XA306 Endangered Species; File Nos. 16266 and... requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et...

  4. 78 FR 50395 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... INFORMATION: On May 31, 2013, notice was published in the Federal Register (78 FR 32622) that requests for a... Service Marine Forensic Lab (NOS Lab) , 219 Fort Johnson Road, Charleston, SC 29412 (File No. 17557),...

  5. 76 FR 80890 - Endangered Species; File Nos. 13599 and 1614

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ...-01, issued on September 20, 2010 (73 FR 78724), authorizes the permit holder to receive, import...-01, (73 FR 25668) issued on April 30, 2008 authorizes the permit holder to collect, receive and... permits: the National Ocean Service Marine Forensic Lab (NOS Lab) , 219 Fort Johnson Road, Charleston,...

  6. 77 FR 21753 - Endangered Species; File Nos. 13599 and 1614

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    .... SUPPLEMENTARY INFORMATION: On December 27, 2011, notice was published in the Federal Register (76 FR 80890) that... and threatened species (50 CFR 222-226). Permit No. 13599, issued December 16, 2008 (73 FR 78724... mammal and endangered species parts. Permit No. 1614, issued February 28, 2008 (73 FR 11873),...

  7. 77 FR 1061 - Endangered Species; File Nos. 16229 and 16548

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... the Federal Register (76 FR 51945 and 76 FR 40699) that requests for enhancement permits to take... Zoo, 4401 Zoo ] Parkway, Asheboro, NC 27203 , and the Springfield Science Museum, 21 Edwards Street... species (50 CFR parts 222-226). The North Carolina Zoo and the Springfield Science Museum have been...

  8. 76 FR 37065 - Endangered Species; File Nos. 16266 and 16291

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... was published in the Federal Register (76 FR 15300) that a request for enhancement permits to take... Aquarium at Norwalk, 10 North Water Street, South Norwalk, CT 06854 have been issued permits to take... species (50 CFR Parts 222-226). The Virginia Living Museum and the Maritime Aquarium at Norwalk have...

  9. 75 FR 16428 - Endangered Species; File Nos. 15112 and 13307-02

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... for purposes of scientific research. Kristen Hart, Ph.D., USGS, Davie, FL has applied for a modification to scientific research Permit No. 13307-01 to take green sea turtles. DATES: Written, telefaxed... species (50 CFR 222-226). File No. 15112: The purpose of the research is to determine the size...

  10. 75 FR 76704 - Endangered Species; File Nos. 13307, 13544, and 14586

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... published in the Federal Register (75 FR 9580) that a request for a scientific research permit to take sea... for purposes of scientific research. ADDRESSES: The permit and related documents are available for..., FL (File No. 14586). On March 3, 2010, notice was published in the Federal Register (75 FR 9580)...

  11. 76 FR 18725 - Marine Mammals; File Nos. 14330 and 14335

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ...Notice is hereby given that the following applicants have been issued major amendments to permits for research on marine mammals in Alaska: (File No. 14330) the Aleut Community of St. Paul Island, Tribal Government, Ecosystem Conservation Office, St. Paul Island, AK; and (File No. 14335) the Alaska SeaLife Center, Seward,...

  12. 75 FR 42689 - Marine Mammals; File Nos. 15498 and 15500

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ...: On May 3, 2010, notice was published in the Federal Register (75 FR 23242) that requests for public display permits to import bottlenose dolphins had been submitted by the above-named organizations. File No..., NW., Atlanta, GA 30313 have been issued permits to import Atlantic bottlenose dolphins...

  13. 76 FR 51001 - Marine Mammals; File Nos. 16109 and 15575

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... 44 species to be targeted for research are listed as threatened or endangered: blue whale (Balaenoptera musculus), fin whale (B. physalus), humpback whale (Megaptera novaeangliae), North Atlantic right whale (Eubalaena glacialis), sei whale (B. borealis), sperm whale (Physeter macrocephalus), green...

  14. 77 FR 27719 - Marine Mammals; File Nos. 16109 and 15575

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... was published in the Federal Register (76 FR 51001) that requests for permits to conduct research on... targeted for research are listed as threatened or endangered: Blue whale (Balaenoptera musculus), fin whale... species to be targeted for research are listed as threatened or endangered: Blue whale, fin...

  15. 77 FR 67341 - Endangered Species; File No. 15809

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... National Oceanic and Atmospheric Administration RIN 0648-XC325 Endangered Species; File No. 15809 AGENCY... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No..., Permits and Conservation Division By email to NMFS.Pr1Comments@noaa.gov (include the File No. in...

  16. 76 FR 51945 - Endangered Species; File No. 16548

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... National Oceanic and Atmospheric Administration RIN 0648-XA648 Endangered Species; File No. 16548 AGENCY... Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 16548 from the list of...- 0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include the File No. 16548 in the subject...

  17. 78 FR 13642 - Endangered Species; File No. 17506

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XC518 Endangered Species; File No. 17506 AGENCY... Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 17506 from the list of...: By email to NMFS.Pr1Comments@noaa.gov (include the File No. in the subject line of the email),...

  18. 76 FR 76950 - Endangered Species; File No. 16134

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... National Oceanic and Atmospheric Administration RIN 0648-XA848 Endangered Species; File No. 16134 AGENCY... Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 16134 from the list of... Conservation Division. By email to NMFS.Pr1Comments@noaa.gov (include the File No. in the subject line of...

  19. 76 FR 51980 - Atlantic Shipping Company, Inc. v. Di Nos Shipping, Inc.; Notice of Filing of Complaint and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... From the Federal Register Online via the Government Publishing Office ] FEDERAL MARITIME COMMISSION Atlantic Shipping Company, Inc. v. Di Nos Shipping, Inc.; Notice of Filing of Complaint and Assignment Notice is given that a complaint has been filed with the Federal Maritime Commission (Commission) by Atlantic Shipping Company, Inc.,...

  20. 76 FR 37327 - Endangered Species; File No. 16253

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ... National Oceanic and Atmospheric Administration RIN 0648-XA518 Endangered Species; File No. 16253 AGENCY... requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 16253 from...

  1. 76 FR 48806 - Endangered Species; File No. 16194

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... National Oceanic and Atmospheric Administration RIN 0648-XA625 Endangered Species; File No. 16194 AGENCY... the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the... for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No....

  2. 75 FR 11862 - Endangered Species; File No. 14759

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... National Oceanic and Atmospheric Administration RIN 0648-XV04 Endangered Species; File No. 14759 AGENCY... the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.), and the regulations... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov/ , and then selecting File No. 14759 from...

  3. 76 FR 27306 - Endangered Species; File No. 15661

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XA425 Endangered Species; File No. 15661 AGENCY... requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File...

  4. 75 FR 67682 - Endangered Species; File No. 15566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... National Oceanic and Atmospheric Administration RIN 0648-XA013 Endangered Species; File No. 15566 AGENCY... the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15566 from...

  5. 77 FR 39220 - Endangered Species; File No. 17183

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... National Oceanic and Atmospheric Administration RIN 0648-XC078 Endangered Species; File No. 17183 AGENCY.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of... for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No....

  6. 75 FR 9868 - Endangered Species; File No. 14622

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... National Oceanic and Atmospheric Administration RIN 0648-XU82 Endangered Species; File No. 14622 AGENCY.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 14622 from...

  7. 78 FR 29114 - Endangered Species; File No. 17304

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... National Oceanic and Atmospheric Administration RIN 0648-XC667 Endangered Species; File No. 17304 AGENCY... INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of 1973, as... Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 17304 from the list...

  8. 78 FR 17640 - Endangered Species; File Nos. 17367 and 17364

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... FR 67631) that requests for scientific research permits to take shortnose sturgeon and/or Atlantic.... Research would include, but is not limited to, nutrition, physiology, propagation, contaminants, genetics... research animals for studies related to tagging, tracking, behavior, physiology, genetics,...

  9. 75 FR 33578 - Endangered Species; File Nos. 14508 and 14655

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ... September 29, 2009, notice was published in the Federal Register (74 FR 38169 and 74 FR 49851) that requests...), Commerce. ACTION: Issuance of permits. SUMMARY: Notice is hereby given that Inwater Research Group, Inc... annually. Turtles may be flipper and passive integrated transponder tagged, blood and tissue...

  10. 77 FR 21750 - Endangered Species; File Nos. 16549 and 17095

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... permit for takes of shortnose sturgeon in the wild and captivity. The applicant proposes to determine up... animal research in laboratory tests of up- and downstream fish passage studies, swimming...

  11. 76 FR 35842 - Endangered Species; File No. 15685

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... National Oceanic and Atmospheric Administration RIN 0648-XA502 Endangered Species; File No. 15685 AGENCY... (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15685 from the list of..., Conservation and Education Division By e-mail to NMFS.Pr1Comments@noaa.gov (include the File No. in the...

  12. 77 FR 13096 - Endangered Species; File No. 16598

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XB054 Endangered Species; File No. 16598 AGENCY... page, https://apps.nmfs.noaa.gov , and then selecting File No. 16598 from the list of available... Division: By email to NMFS.Pr1Comments@noaa.gov (include the File No. in the subject line of the email),...

  13. 75 FR 13488 - Endangered Species; File No. 14949

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... National Oceanic and Atmospheric Administration RIN 0648-XV33 Endangered Species; File No. 14949 AGENCY...://apps.nmfs.noaa.gov/ , and then selecting File No. 14949 from the list of available applications. These... the subject line of the e-mail comment the following document identifier: File No. 14949. FOR...

  14. 77 FR 58812 - Endangered Species; File No. 16733

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... National Oceanic and Atmospheric Administration RIN 0648-XC253 Endangered Species; File No. 16733 AGENCY....gov , and then selecting File No. 16733 from the list of available applications. These documents are...@noaa.gov (include the File No. in the subject line of the email), By facsimile to (301)713-0376, or...

  15. 77 FR 58812 - Endangered Species; File No. 17316

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... National Oceanic and Atmospheric Administration RIN 0648-XC252 Endangered Species; File No. 17316 AGENCY... page, https://apps.nmfs.noaa.gov , and then selecting File No. 17316 from the list of available... By email to NMFS.Pr1Comments@noaa.gov (include the File No. in the subject line of the email),...

  16. 76 FR 58471 - Endangered Species; File No. 15634

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... National Oceanic and Atmospheric Administration RIN 0648-XA714 Endangered Species; File No. 15634 AGENCY....gov , and then selecting File No. 15634 from the list of available applications. These documents are..., Conservation and Education Division By e-mail to NMFS.Pr1Comments@noaa.gov (include the File No. in the...

  17. 76 FR 58471 - Endangered Species; File No. 16306

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... National Oceanic and Atmospheric Administration RIN 0648-XA712 Endangered Species; File No. 16306 AGENCY... then selecting File No. 16306 from the list of available applications. These documents are also... the File No. in the subject line of the e-mail), By facsimile to (301) 713-0376, or At the...

  18. 78 FR 38013 - Endangered Species; File No. 15661

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... modification to Permit No. 15661, issued on January 24, 2012 (77 FR 13097) is requested under the authority of... National Oceanic and Atmospheric Administration RIN 0648-XA425 Endangered Species; File No. 15661 AGENCY... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov/ , and then selecting File No. 15661 from...

  19. 75 FR 13255 - Endangered Species; File No. 15338

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... National Oceanic and Atmospheric Administration RIN 0648-XU83 Endangered Species; File No. 15338 AGENCY... the Endangered Species Act of 1973, as amended (ESA). The Permit application is for the incidental... permits for threatened and endangered species are promulgated at 50 CFR 222.307. Species Covered in...

  20. 78 FR 41034 - Endangered Species; File No. 18102

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC711 Endangered Species; File No. 18102 AGENCY...). Attachments to electronic comments will be accepted in Microsoft Word, Excel, or Adobe PDF file formats...

  1. 76 FR 77781 - Endangered Species; File No. 15802

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... (50 CFR 222-226). On July 28, 2011 (76 FR 45230), notice was published that a permit had been... National Oceanic and Atmospheric Administration RIN 0648-XA603 Endangered Species; File No. 15802 AGENCY... change to the application for a permit (File No. 15802). DATES: Written, telefaxed, or email...

  2. 76 FR 23305 - Endangered Species; File No. 15672

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... National Oceanic and Atmospheric Administration RIN 0648-XA385 Endangered Species; File No. 15672 AGENCY... subject permit is requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16... the Features box on the Applications and Permits for Protected Species (APPS) home page,...

  3. 75 FR 11863 - Endangered Species; File No. 15135

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... National Oceanic and Atmospheric Administration RIN 0648-XV11 Endangered Species; File No. 15135 AGENCY... Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the... Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and...

  4. 76 FR 44306 - Endangered Species; File No. 16146

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XA583 Endangered Species; File No. 16146 AGENCY... under the ] authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and...

  5. 77 FR 37877 - Endangered Species; File No. 17022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XC059 Endangered Species; File No. 17022 AGENCY.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of... Public Comment'' from the Features box on the Applications and Permits for Protected Species (APPS)...

  6. 75 FR 61424 - Endangered Species; File No. 15596

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XZ37 Endangered Species; File No. 15596 AGENCY... the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the taking, importing, and exporting of endangered and threatened species (50 CFR 222-226)....

  7. 76 FR 48146 - Endangered Species; File No. 1551

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... National Oceanic and Atmospheric Administration RIN 0648-XA620 Endangered Species; File No. 1551 AGENCY.... 1551- 02 is requested under the authority of the Endangered Species Act of 1973, as amended (16 U.S.C... threatened species (50 CFR 222-226). Permit No. 1551, issued on July 24, 2008 (73 FR 44225),...

  8. 77 FR 31586 - Endangered Species; File No. 16556

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... National Oceanic and Atmospheric Administration RIN 0648-XC037 Endangered Species; File No. 16556 AGENCY.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of... Public Comment'' from the Features box on the Applications and Permits for Protected Species (APPS)...

  9. 77 FR 21751 - Endangered Species; File No. 16645

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XB152 Endangered Species; File No. 16645 AGENCY... Natural Resources (GA DNR) has applied in due form for a permit pursuant to the Endangered Species Act of... following office: Endangered Species Division, Office of Protected Resources, NMFS, 1315 East-West...

  10. 76 FR 18725 - Endangered Species; File No. 16174

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... National Oceanic and Atmospheric Administration RIN 0648-XA348 Endangered Species; File No. 16174 AGENCY... subject permit is requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16... box on the Applications and Permits for Protected Species (APPS) home page,...

  11. 75 FR 13256 - Endangered Species; File No. 14176

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... National Oceanic and Atmospheric Administration RIN 0648-XV28 Endangered Species; File No. 14176 AGENCY... permit is requested under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C... Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov/ , and...

  12. 76 FR 45230 - Endangered Species; File No. 15802

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XA603 Endangered Species; File No. 15802 AGENCY.... SUPPLEMENTARY INFORMATION: The subject permit is requested under the authority of the Endangered Species Act of... to take smalltooth sawfish and listed sea turtle species for purposes of scientific research....

  13. 76 FR 40699 - Endangered Species; File No. 16229

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XA516 Endangered Species; File No. 16229 AGENCY... the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations... Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and...

  14. 75 FR 22106 - Endangered Species; File No. 14510

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... National Oceanic and Atmospheric Administration RIN 0648-XW06 Endangered Species; File No. 14510 AGENCY... been issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531...: On November 18, 2009, notice was published in the Federal Register (74 FR 59525) that a request for...

  15. 76 FR 32144 - Endangered Species; File No. 15677

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... National Oceanic and Atmospheric Administration RIN 0648-XA467 Endangered Species; File No. 15677 AGENCY... permit has been issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S... 30, 2010, notice was published in the Federal Register (75 FR 74003) that a scientific...

  16. 78 FR 38952 - Endangered Species; File No. 17506

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XC518 Endangered Species; File No. 17506 AGENCY... Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the..., notice was published in the Federal Register (78 FR 13642) that a request for a scientific...

  17. 75 FR 7443 - Endangered Species; File No. 14381

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... National Oceanic and Atmospheric Administration RIN 0648-XU26 Endangered Species; File No. 14381 AGENCY... issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq...: On May 22, 2009, notice was published in the Federal Register (74 FR 23995) that a request for...

  18. 78 FR 3882 - Endangered Species; File No. 13543

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-17

    ... National Oceanic and Atmospheric Administration RIN 0648-XJ40 Endangered Species; File No. 13543 AGENCY.... SUPPLEMENTARY INFORMATION: The subject modification to Permit No. 13543, issued on May 6, 2009 (74 FR 20926) is requested under the authority of the Endangered Species Act of 1973, as amended (16 U.S.C. 1531 et seq.)...

  19. 78 FR 51712 - Endangered Species; File No. 16733

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... National Oceanic and Atmospheric Administration RIN 0648-XC253 Endangered Species; File No. 16733 AGENCY... Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the... published in the Federal Register (77 FR 58812) that a request for a scientific research permit to...

  20. 75 FR 21601 - Endangered Species; File No. 14604

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... National Oceanic and Atmospheric Administration RIN 0648-XV94 Endangered Species; File No. 14604 AGENCY... Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations governing the... Register (74 FR 59961) that a request for a scientific research permit to take shortnose sturgeon had...

  1. 77 FR 10724 - Endangered Species; File No. 16253

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... National Oceanic and Atmospheric Administration RIN 0648-XB027 Endangered Species; File No. 16253 AGENCY... permit has been issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.... SUPPLEMENTARY INFORMATION: On June 27, 2011, notice was published in the Federal Register (76 FR 37327) that...

  2. 75 FR 61133 - Endangered Species; File No. 14176

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... National Oceanic and Atmospheric Administration RIN 0648-XZ31 Endangered Species; File No. 14176 AGENCY... issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq... Register (75 FR 13256) that a request for a scientific research permit to take shortnose sturgeon had...

  3. 77 FR 1671 - Endangered Species; File No. 16194

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... National Oceanic and Atmospheric Administration RIN 0648-XA925 Endangered Species; File No. 16194 AGENCY... been issued under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531..., 2011, notice was published in the ] Federal Register (76 FR 48806) that a request for a...

  4. 77 FR 57559 - Endangered Species; File No. 13330

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ... National Oceanic and Atmospheric Administration RIN 0648-XB144 Endangered Species; File No. 13330 AGENCY... modification has been granted under the authority of the Endangered Species Act of 1973, as amended (ESA; 16 U..., notice was published in the Federal Register (77 FR 19648) that a modification of Permit No....

  5. 75 FR 26715 - Endangered Species; File No. 1596

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... National Oceanic and Atmospheric Administration RIN 0648-XW36 Endangered Species; File No. 1596 AGENCY... modification to Permit No. 1596- 02, issued on July 29, 2009 (74 FR 38585), is requested under the authority of the Endangered Species Act of 1973, as amended (16 U.S.C. 1531 et seq.) and the regulations...

  6. 78 FR 5779 - Endangered Species; File No. 16248

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... National Oceanic and Atmospheric Administration RIN 0648-XC322 Endangered Species; File No. 16248 AGENCY... organization. The requested permit has been issued under the authority of the Endangered Species Act of 1973... INFORMATION: On October 30, 2012, notice was published in the Federal Register (77 FR 65673) that a...

  7. 76 FR 66042 - Endangered Species; File No. 1551

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XA785 Endangered Species; File No. 1551 AGENCY... of the Endangered Species Act of 1973, as amended (ESA; 16 U.S.C. 1531 et seq.) and the regulations... Register (76 FR 48146) that a modification of Permit No. 1551, issued July 24, 2008 (73 FR 44225) had...

  8. 78 FR 22517 - Endangered Species; File No. 16549

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    ... National Oceanic and Atmospheric Administration RIN 0648-XB155 Endangered Species; File No. 16549 AGENCY... applicant. The requested permit has been issued under the authority of the Endangered Species Act of 1973.... SUPPLEMENTARY INFORMATION: On April 11, 2012, notice was published in the Federal Register (77 FR 21750) that...

  9. 78 FR 22239 - Endangered Species; File No. 16556

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    .... SUPPLEMENTARY INFORMATION: On May 29, 2012, notice was published in the Federal Register (77 FR 31586) that a... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC037 Endangered Species; File No. 16556...

  10. 78 FR 59657 - Endangered Species; File No. 17304

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... the Federal Register (78 FR 29114) that a request for a scientific research permit to take loggerhead... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC667 Endangered Species; File No. 17304...

  11. 76 FR 22677 - Endangered Species; File No. 14949

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... Federal Register (75 FR 13488) that a request for a scientific research permit to take green and hawksbill... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA382 Endangered Species; File No. 14949...

  12. 77 FR 24686 - Endangered Species; File No. 15634

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... Register (76 FR 58471) that a request for a scientific research permit to take leatherback sea turtles had... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA714 Endangered Species; File No. 15634...

  13. 76 FR 22877 - Endangered Species; File No. 15566

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    .... SUPPLEMENTARY INFORMATION: On November 3, 2010, notice was published in the Federal Register (75 FR 67682) that... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA387 Endangered Species; File No. 15566...

  14. 76 FR 45781 - Endangered Species; File No. 15552

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... INFORMATION: On January 26, 2011, notice was published in the Federal Register (76 FR 4636) that a request for... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA601 Endangered Species; File No. 15552...

  15. 78 FR 31519 - Endangered Species; File No. 13543

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... was published in the Federal Register (78 FR 3882) that a modification to Permit No. 13543, issued April 30, 2009 (74 FR 20926), had been requested by the above-named organization. The requested... National Oceanic and Atmospheric Administration RIN 0648-XJ40 Endangered Species; File No. 13543...

  16. 78 FR 2659 - Endangered Species; File No. 16645

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... INFORMATION: On April 11, 2012, notice was published in the Federal Register (77 FR 21751) that a request for... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB152 Endangered Species; File No. 16645...

  17. 75 FR 78227 - Endangered Species; File No. 14400

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ... INFORMATION: On August 27, 2009, notice was published in the Federal Register (74 FR 43679) that a request for... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA085 Endangered Species; File No. 14400...

  18. 77 FR 40588 - Endangered Species; File No. 16598

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    .... SUPPLEMENTARY INFORMATION: On March 5, 2012, notice was published in the Federal Register (77 FR 13096) that a... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB054 Endangered Species; File No. 16598...

  19. 78 FR 50396 - Endangered Species; File No. 17405

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... Register (78 FR 14078) that a request for a scientific research permit to take black abalone had been... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC519 Endangered Species; File No. 17405...

  20. 75 FR 53278 - Endangered Species; File No. 14759

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    .... SUPPLEMENTARY INFORMATION: On March 12, 2010, notice was published in the Federal Register (75 FR 11862) that a... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XY58 Endangered Species; File No. 14759...

  1. 78 FR 26323 - Endangered Species; File No. 17183

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ...-8401. SUPPLEMENTARY INFORMATION: On July 2, 2012, notice was published in the Federal Register (77 FR... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC078 Endangered Species; File No. 17183...

  2. 77 FR 55194 - Endangered Species; File No. 17095

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... Federal Register (77 FR 21750) that a request for a scientific research permit to take shortnose sturgeon... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB155 Endangered Species; File No. 17095...

  3. 78 FR 57132 - Endangered Species; File No. 16230

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... and a request for public comments on October 5, 2011 (76 FR 61670). Based on comments received from... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC289 Endangered Species; File No. 16230...

  4. 77 FR 61745 - Endangered Species; File No. 16803

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    ... Register (77 FR 34349) that a request for a scientific research permit to take loggerhead, green, and olive... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC058 Endangered Species; File No. 16803...

  5. 76 FR 77780 - Endangered Species; File No. 10022

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... FR 78974) that a modification of Permit No. 10022-01, issued May 12, 2010 (75 FR 26715), had been... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XA867 Endangered Species; File No. 10022...

  6. 76 FR 19052 - Endangered Species; File No. 14344

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... National Oceanic and Atmospheric Administration RIN 0648-XA340 Endangered Species; File No. 14344 AGENCY... above-named organization. The requested permit has been issued under the authority of the Endangered.... SUPPLEMENTARY INFORMATION: On August 27, 2009, notice was published in the Federal Register (74 FR 43679) that...

  7. 76 FR 68161 - Marine Mammals; File Nos. 16163, 16160, and 15569

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... are listed as endangered or have a stock listed as endangered: blue whale (Balaenoptera musculus), fin... species that are listed as endangered include the blue whale, fin whale, sei whale, humpback whale, and...], 2725 Montlake Blvd. East, Seattle, WA 98112-2097; The Whale Museum (Jenny Atkinson, Responsible...

  8. 78 FR 2955 - Marine Mammals; File Nos. 14451, 14353, and 13846

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... species (50 CFR 222-226). Permit No. 14451, issued on July 14, 2010 (75 FR 43151), authorizes the permit..., issued on July 14, 2010 (75 FR 43151), authorizes the permit holder, Ann Zoidis, Cetos Research... the Northwestern Hawaiian Islands (NWHI) chain. Permit No. 13846, issued on July 14, 2010 (75 FR...

  9. 75 FR 60734 - Endangered Species; File No. 13599-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    .... SUPPLEMENTARY INFORMATION: On May 25, 2010, notice was published in the Federal Register (75 FR 29316) that a modification of Permit No. 13599, ] issued December 16, 2008 (73 FR 78724), had been requested by the above... Service Marine Forensic Lab (NOS Lab, Julie Carter, Principal Investigator), 219 Fort Johnson...

  10. 76 FR 23571 - Marine Mammals and Endangered Species; File Nos. 15415 and 14622

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... December 10, 2010, notice was published in the Federal Register (75 FR 76956) that a request for a permit... D. Kraus, Ph.D. . On March 4, 2010, notice was published in the Federal Register (75 FR 9868) that a... given that NMFS has issued two permits to conduct research on marine mammals or sea turtles....

  11. 76 FR 58469 - Endangered Species; File Nos. 16526, 16323, 16436, 16422, 16438, 16431, 16507, 16547, 16375...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... below. For specific take numbers of each research project, please refer to the associated application..., movement, habitat preferences and biology in the Delaware River and Bay. The applicant would...

  12. 77 FR 21754 - Endangered Species; File Nos. 16526, 16323, 16436, 16422, 16438, 16431, 16507, 16547, 16375...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... 21, 2011, notice was published in the Federal Register (76 FR 58469) that 12 requests for scientific... Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus) for purposes of scientific research. See SUPPLEMENTARY... five-year permit to conduct scientific research on Atlantic sturgeon in the rivers and estuaries...

  13. 75 FR 9580 - Marine Mammals and Endangered Species; File Nos. 13544 and 14586

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ..., Naples, FL 34102, has requested a modification to scientific research Permit No. 13544 and Jeanette Wyneken, Florida Atlantic University, Boca Raton, FL 33431, has applied in due form to conduct scientific... Permit No. 13544, issued on April 17, 2009 (74 FR 18354) is requested under the authority of...

  14. 77 FR 13097 - Endangered Species; File Nos. 15661, 10027, and 15685

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... Federal Register (76 FR 27306) that a request for a scientific research permit to take green and hawksbill... Federal Register (76 FR 34967) that a request for a scientific research permit modification to take green... in the Federal Register (76 FR 35842) that a request for a scientific research permit to take...

  15. 78 FR 23225 - Endangered Species; File Nos. 14759-01 and 16375-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... issued August 20, 2010 (75 FR 53278), and Permit No. 16375 was issued on April 6, 2012 (77 FR 21754) to... is now requesting authorization to modify both permits to allow use of artificial substrates for... artificial substrates be used for collecting up to 50 shortnose sturgeon and 50 Atlantic sturgeon early...

  16. 76 FR 34967 - Endangered Species; File No. 10027

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    .... 10027, issued on July 30, 2008 (73 FR 44224), is requested under the authority of the Endangered Species...: Eleanor Sterling, PhD), Central Park West at 79th Street, New York, New York 10024, has requested...

  17. 76 FR 6118 - Endangered Species; File No. 14726

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... threatened species (50 CFR 222-226). Permit No. 14726, issued on September 3, 2010 (75 FR 61133), authorizes... Blair Witherington, PhD, Florida Fish and Wildlife Conservation Commission, 9700 South A1A,...

  18. 78 FR 66901 - Endangered Species; File No. 16482-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ...) and shortnose sturgeon (Acipenser brevirostrum) for purposes of scientific research. DATES: Written... threatened species (50 CFR parts 222-226). Permit No. 16482 was issued April 6, 2012 (77 FR 21754) to...

  19. 75 FR 61133 - Marine Mammals and Endangered Species; File Nos. 808-1735, 14233, 14506, 14603, and 14726

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    .... SUPPLEMENTARY INFORMATION: On March 11, 2010, notice was published in the Federal Register (75 FR 11516) that a... submitted by Andrew Read, Ph.D. . On September 10, 2009, notice was published in the Federal Register (74 FR... Federal Register (74 FR 66618) that a request for a permit to conduct research on green (Chelonia...

  20. 76 FR 30309 - Marine Mammals and Endangered Species; File Nos. 14245, 1596-03, and 14726-01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ..., 2010 and December 29, 2010, notices were published in the Federal Register (75 FR 26715 and 81970.... On May 12, 2010, notice was published in the Federal Register (75 FR 26715) that a modification of... Beach, FL, 32951 was issued a modification to Permit No. 14726, issued September 3, 2010 (75 FR...

  1. Reactive oxygen species- and nitric oxide-mediated lung inflammation and mitochondrial dysfunction in wild-type and iNOS-deficient mice exposed to diesel exhaust particles.

    PubMed

    Zhao, Hongwen; Ma, Joseph K; Barger, Mark W; Mercer, Robert R; Millecchia, Lyndell; Schwegler-Berry, Diane; Castranova, Vince; Ma, Jane Y

    2009-01-01

    Pulmonary responses to diesel exhaust particles (DEP) exposure are mediated through enhanced production of reactive oxygen species (ROS) and nitric oxide (NO) by alveolar macrophages (AM). The current study examined the differential roles of ROS and NO in DEP-induced lung injury using C57B/6J wild-type (WT) and inducible NO synthase knockout (iNOS KO) mice. Mice exposed by pharyngeal aspiration to DEP or carbon black particles (CB) (35 mg/kg) showed an inflammatory profile that included neutrophil infiltration, increased lactate dehydrogenase (LDH) activity, and elevated albumin content in bronchoalveolar lavage fluid (BALF) at 1, 3, and 7 d postexposure. The organic extract of DEP (DEPE) did not induce an inflammatory response. Comparing WT to iNOS KO mice, the results show that NO enhanced DEP-induced neutrophils infiltration and plasma albumin content in BALF and upregulated the production of the pro-inflammatory cytokine interleukin 12 (IL-12) by AM. DEP-exposed AM from iNOS KO mice displayed diminished production of IL-12 and, in response to ex vivo lipopolysaccharide (LPS) challenge, decreased production of IL-12 but increased production of IL-10 when compared to cells from WT mice. DEP, CB, but not DEPE, induced DNA damage and mitochondria dysfunction in AM, however, that is independent of cellular production of NO. These results demonstrate that DEP-induced immune/inflammatory responses in mice are regulated by both ROS- and NO-mediated pathways. NO did not affect ROS-mediated mitochondrial dysfunction and DNA damage but upregulated IL-12 and provided a counterbalance to the ROS-mediated adaptive stress response that downregulates IL-12 and upregulates IL-10. PMID:19267316

  2. Permanent-File-Validation Utility Computer Program

    NASA Technical Reports Server (NTRS)

    Derry, Stephen D.

    1988-01-01

    Errors in files detected and corrected during operation. Permanent File Validation (PFVAL) utility computer program provides CDC CYBER NOS sites with mechanism to verify integrity of permanent file base. Locates and identifies permanent file errors in Mass Storage Table (MST) and Track Reservation Table (TRT), in permanent file catalog entries (PFC's) in permit sectors, and in disk sector linkage. All detected errors written to listing file and system and job day files. Program operates by reading system tables , catalog track, permit sectors, and disk linkage bytes to vaidate expected and actual file linkages. Used extensively to identify and locate errors in permanent files and enable online correction, reducing computer-system downtime.

  3. 76 FR 39910 - Nine Mile Point Nuclear Station, LLC; Nine Mile Point Nuclear Station, Unit Nos. 1 and 2; Notice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires... COMMISSION Nine Mile Point Nuclear Station, LLC; Nine Mile Point Nuclear Station, Unit Nos. 1 and 2; Notice... Nos. DPR-63 and NPF-69 for the Nine Mile Point Nuclear Station, Unit Nos. 1 and 2 (NMP),...

  4. 76 FR 64937 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... Company. Description: Notices of Termination of CalPeak Vaca Dixon and Panoche Service Agreement Nos. 39...: http://www.ferc.gov/docs-filing/efiling/filing-req.pdf . For other information, call (866)...

  5. 76 FR 51447 - Self-Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... Exchange Act Release Nos. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014...-047); 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010- 025). \\7\\ See e.g.,Securities Exchange Act Release Nos. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos....

  6. 76 FR 39908 - Calvert Cliffs Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August... COMMISSION Calvert Cliffs Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2.... DPR-53 and DPR-69, for the Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2 (CCNPP),...

  7. mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models

    PubMed Central

    Colton, Carol A.; Wilson, Joan G.; Everhart, Angela; Wilcock, Donna M.; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P.

    2014-01-01

    Abstract Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease–like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI+/+/mNos2−/− (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI+/−/HuNOS2tg+/+/mNos2−/−) mimicked the pathologic phenotypes found in the CVN-AD strain. PMID:25003233

  8. mNos2 deletion and human NOS2 replacement in Alzheimer disease models.

    PubMed

    Colton, Carol A; Wilson, Joan G; Everhart, Angela; Wilcock, Donna M; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P

    2014-08-01

    Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease-like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI(+)/(+)mNos2(-/-) (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI(+)/(-)/HuNOS2(tg+)/(+)/mNos2(-/-)) mimicked the pathologic phenotypes found in the CVN-AD strain. PMID:25003233

  9. Langley VEDIT for NOS/VE usage manual

    NASA Technical Reports Server (NTRS)

    Heaney, Margaret A.

    1987-01-01

    The use of the VEDIT editor on the CDC Network Operating System/Virtual Environment (NOS/VE) is discussed. The VEDIT, a utility, allows a user to edit files line by line (line mode). How to access and the use of VEDIT are explained. The parameters and the format of the individual commands are defined. Examples are included.

  10. Service building. Cross section thru dry dock nos. 4 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Service building. Cross section thru dry dock nos. 4 & 5 showing service bldg & 20-75-150 ton cranes (dry dock associates, May 23, 1941). In files of Cushman & Wakefield, building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Service Building, Dry Docks No. 4 & 5, League Island, Philadelphia, Philadelphia County, PA

  11. 15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. I and II (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  12. 16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Dry Dock No. 4. Longitudinal Section. Subdivision Nos. III and IV (Frederic R. Harris, Inc., January 10, 1941). In Files of Cushman & Wakefield, Building no. 501, Philadelphia Naval Business Center. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 4, Broad Street south of Government Avenue, Philadelphia, Philadelphia County, PA

  13. 77 FR 17470 - Notice of Compliance Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Compliance Filing Docket Nos. OREG 1, Inc EL11-22-000 OREG 2, Inc...., OREG 2, Inc., OREG 3, Inc., and OREG 4, Inc filed compliance refund reports, pursuant to the...

  14. The NOS Challenge

    ERIC Educational Resources Information Center

    Quigley, Cassie; Buck, Gayle; Akerson, Valarie

    2011-01-01

    "The picture of a scientist is me!" exclaims first grader Kendra during a nature of science (NOS) lesson. She drew a picture of a scientist and explained that she was going to be a scientist when she grew up because she "loved to observe like a scientist." Kendra's experience was a part of a 30-day unit designed specifically for first graders.…

  15. 78 FR 52598 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing of Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... COMMISSION Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing of Proposed..., the Fixed Income Clearing Corporation (``FICC'') filed with the Securities and Exchange Commission...) the counterparty submits corresponding NOS to match the initiator's submission, (b) the...

  16. 76 FR 51089 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA- 2010-01; SR-EDGX-2010-01; SR-BX-2010... 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044; SR-CBOE-2010... (June 23, 2011), 76 FR 38243 (June 29, 2011) (File Nos. SR-BATS-2011-016; SR-BYX- 2011-011;...

  17. 75 FR 3458 - Combined Notice of Filings # 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ..., January 28, 2010. Docket Numbers: OA10-5-000. Applicants: ConocoPhillips Company. Description: Request for Waiver of Order Nos. 888, 889, and 890 and Part 358 of ConocoPhillips Company. Filed Date:...

  18. 76 FR 74086 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ... Exchange Act Release No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS- 2010-014...) and Securities Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA... Exchange Act Release No. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos....

  19. 76 FR 2174 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... Securities Exchange Act Release No. 35993 (July 19, 1995), 60 FR 38073 (July 25, 1995) (approving File Nos..., 1998), 63 FR 64297 (November 19, 1998) (approving File Nos. SR-Amex-98-21, SR-CBOE-98-29, SR-PCX-98- 31... Price Program. See Securities Exchange Act Release No. 52960 (December 15, 2005), 70 FR 76090...

  20. XML Files

    MedlinePlus

    ... nlm.nih.gov/medlineplus/xml.html MedlinePlus XML Files To use the sharing features on this page, ... information on all English and Spanish topic groups. Files generated on July 09, 2016 MedlinePlus Health Topic ...

  1. Contribution of the nos-pdt operon to virulence phenotypes in methicillin-sensitive Staphylococcus aureus.

    PubMed

    Sapp, April M; Mogen, Austin B; Almand, Erin A; Rivera, Frances E; Shaw, Lindsey N; Richardson, Anthony R; Rice, Kelly C

    2014-01-01

    Nitric oxide (NO) is emerging as an important regulator of bacterial stress resistance, biofilm development, and virulence. One potential source of endogenous NO production in the pathogen Staphylococcus aureus is its NO-synthase (saNOS) enzyme, encoded by the nos gene. Although a role for saNOS in oxidative stress resistance, antibiotic resistance, and virulence has been recently-described, insights into the regulation of nos expression and saNOS enzyme activity remain elusive. To this end, transcriptional analysis of the nos gene in S. aureus strain UAMS-1 was performed, which revealed that nos expression increases during low-oxygen growth and is growth-phase dependent. Furthermore, nos is co-transcribed with a downstream gene, designated pdt, which encodes a prephenate dehydratase (PDT) enzyme involved in phenylalanine biosynthesis. Deletion of pdt significantly impaired the ability of UAMS-1 to grow in chemically-defined media lacking phenylalanine, confirming the function of this enzyme. Bioinformatics analysis revealed that the operon organization of nos-pdt appears to be unique to the staphylococci. As described for other S. aureus nos mutants, inactivation of nos in UAMS-1 conferred sensitivity to oxidative stress, while deletion of pdt did not affect this phenotype. The nos mutant also displayed reduced virulence in a murine sepsis infection model, and increased carotenoid pigmentation when cultured on agar plates, both previously-undescribed nos mutant phenotypes. Utilizing the fluorescent stain 4-Amino-5-Methylamino-2',7'-Difluorofluorescein (DAF-FM) diacetate, decreased levels of intracellular NO/reactive nitrogen species (RNS) were detected in the nos mutant on agar plates. These results reinforce the important role of saNOS in S. aureus physiology and virulence, and have identified an in vitro growth condition under which saNOS activity appears to be upregulated. However, the significance of the operon organization of nos-pdt and potential

  2. Contribution of the nos-pdt Operon to Virulence Phenotypes in Methicillin-Sensitive Staphylococcus aureus

    PubMed Central

    Almand, Erin A.; Rivera, Frances E.; Shaw, Lindsey N.; Richardson, Anthony R.; Rice, Kelly C.

    2014-01-01

    Nitric oxide (NO) is emerging as an important regulator of bacterial stress resistance, biofilm development, and virulence. One potential source of endogenous NO production in the pathogen Staphylococcus aureus is its NO-synthase (saNOS) enzyme, encoded by the nos gene. Although a role for saNOS in oxidative stress resistance, antibiotic resistance, and virulence has been recently-described, insights into the regulation of nos expression and saNOS enzyme activity remain elusive. To this end, transcriptional analysis of the nos gene in S. aureus strain UAMS-1 was performed, which revealed that nos expression increases during low-oxygen growth and is growth-phase dependent. Furthermore, nos is co-transcribed with a downstream gene, designated pdt, which encodes a prephenate dehydratase (PDT) enzyme involved in phenylalanine biosynthesis. Deletion of pdt significantly impaired the ability of UAMS-1 to grow in chemically-defined media lacking phenylalanine, confirming the function of this enzyme. Bioinformatics analysis revealed that the operon organization of nos-pdt appears to be unique to the staphylococci. As described for other S. aureus nos mutants, inactivation of nos in UAMS-1 conferred sensitivity to oxidative stress, while deletion of pdt did not affect this phenotype. The nos mutant also displayed reduced virulence in a murine sepsis infection model, and increased carotenoid pigmentation when cultured on agar plates, both previously-undescribed nos mutant phenotypes. Utilizing the fluorescent stain 4-Amino-5-Methylamino-2',7'-Difluorofluorescein (DAF-FM) diacetate, decreased levels of intracellular NO/reactive nitrogen species (RNS) were detected in the nos mutant on agar plates. These results reinforce the important role of saNOS in S. aureus physiology and virulence, and have identified an in vitro growth condition under which saNOS activity appears to be upregulated. However, the significance of the operon organization of nos-pdt and potential

  3. Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling

    PubMed Central

    Förstermann, Ulrich; Li, Huige

    2011-01-01

    Nitric oxide (NO) produced by the endothelium is an important protective molecule in the vasculature. It is generated by the enzyme endothelial NO synthase (eNOS). Similar to all NOS isoforms, functional eNOS transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH), via the flavins flavin adenine dinucleotide and flavin mononucleotide in the carboxy-terminal reductase domain, to the heme in the amino-terminal oxygenase domain. Here, the substrate L-arginine is oxidized to L-citrulline and NO. Cardiovascular risk factors such as diabetes mellitus, hypertension, hypercholesterolaemia or cigarette smoking reduce bioactive NO. These risk factors lead to an enhanced production of reactive oxygen species (ROS) in the vessel wall. NADPH oxidases represent major sources of this ROS and have been found upregulated in the presence of cardiovascular risk factors. NADPH-oxidase-derived superoxide avidly reacts with eNOS-derived NO to form peroxynitrite (ONOO-). The essential NOS cofactor (6R-)5,6,7,8-tetrahydrobiopterin (BH4) is highly sensitive to oxidation by this ONOO-. In BH4 deficiency, oxygen reduction uncouples from NO synthesis, thereby converting NOS to a superoxide-producing enzyme. Among conventional drugs, compounds interfering with the renin-angiotensin-aldosterone system and statins can reduce vascular oxidative stress and increase bioactive NO. In recent years, we have identified a number of small molecules that have the potential to prevent eNOS uncoupling and, at the same time, enhance eNOS expression. These include the protein kinase C inhibitor midostaurin, the pentacyclic triterpenoids ursolic acid and betulinic acid, the eNOS enhancing compounds AVE9488 and AVE3085, and the polyphenolic phytoalexin trans-resveratrol. Such compounds enhance NO production from eNOS also under pathophysiological conditions and may thus have therapeutic potential. PMID:21198553

  4. 76 FR 10344 - Combined Notice of Filings #1

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    .... 310 between APS and Perrin Ranch Wind, LLC. to be effective 1/13/2011. Filed Date: 02/14/2011... above list. They are also available for review in the Commission's Public Reference Room in Washington... tariff filing per 35.13(a)(2)(iii): Amendments to Solar Partners LGIAs SA Nos. 73, 78 and 85 to...

  5. 76 FR 17411 - Notice of Intent To File License Application, Filing of Pre-Application Document, and Approving...

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    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Intent To File License Application, Filing of Pre- Application Document, and Approving Use of the Traditional Licensing Process Project Nos. Free Flow Power Corporation P-13441-001 P-13456-001 P-13455-001...

  6. 77 FR 64959 - Marine Mammals; File Nos. 15777 and 17670

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    ...) was made available for public comment on May 4, 2012 (77 FR 26513). In response to public comments..., hair, swab samples, vibrissae), and attachment of telemetry devices. Up to 200 harp seals, 50...

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    2010-05-03

    ..., Atlanta, GA 30313, have each applied in due form for a permit to import Atlantic bottlenose dolphins... female captive born bottlenose dolphin from Dolphin Quest Bermuda, Hamilton, Bermuda, to the Brookfield... dolphins from Dolphin Experience, Ltd., Freeport, Grand Bahama Island, The Bahamas, and three...

  8. 78 FR 21112 - Marine Mammals; File Nos. 16992 and 14535

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    ... amendment to Permit No. 14535-01 (75 FR 58352) to allow the addition of TTS studies to the currently..., Ph.D., Hawaii Institute of Marine Biology, University of Hawaii, P.O. Box 1106, Kailua, HI 96734, has... of Marine Biology in Kaneohe, HI. Researchers would conduct hearing measurements using suction...

  9. 78 FR 60852 - Marine Mammals; File Nos. 16239 and 17312

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    ... (77 FR 60966 and 78 FR 23538) for No. 16239 and No. 17312, respectively, that requests for permits to... issued to Dan Engelhaupt, Ph.D., HDR EOC, 5700 Lake Wright Drive, Norfolk, VA 23502- 1859, and Scripps Institution of Oceanography [Responsible Party: John Hildebrand, Ph.D.], University of California,...

  10. 75 FR 37389 - Marine Mammals; File Nos. 14628 and 15471

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    2010-06-29

    ... purposes:National Museum of Natural History, Smithsonian Institution (Charles W. Potter, Responsible Party... Museum of Natural History (NMNH) is requesting authorization to collect, import, export, possess,...

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    ...), 75 FR 69489 (November 12, 2010)(NASDAQ-2010-141) (notice of filing and immediate effectiveness)(the ``ISP Filing''). See also Securities Exchange Act Release Nos. 63414 (December 2, 2010), 75 FR 76505..., 2011), 76 FR 1201 (January 7, 2011)(NASDAQ-2010-154) (notice of filing and immediate effectiveness)....

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    ... No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS- 2010-014; SR-EDGA-2010-01... Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). \\4\\ The... (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044;...

  13. Compress Your Files

    ERIC Educational Resources Information Center

    Branzburg, Jeffrey

    2005-01-01

    File compression enables data to be squeezed together, greatly reducing file size. Why would someone want to do this? Reducing file size enables the sending and receiving of files over the Internet more quickly, the ability to store more files on the hard drive, and the ability pack many related files into one archive (for example, all files…

  14. Hyperglycemia induces iNOS gene expression and consequent nitrosative stress via JNK activation

    PubMed Central

    YANG, Peixin; CAO, Yuanning; LI, Hua

    2010-01-01

    Objective Maternal diabetes adversely impacts embryonic development. We test the hypothesis that hyperglycemia-induced JNK1/2 activation mediates iNOS induction. Study Design Levels of iNOS mRNA and nitrosylated protein were determined in cultured C57BL/6J conceptuses exposed to hyperglycemia (300 mg/dl glucose) and C57BL/6J embryos exposed to streptozotocin-induced diabetes. iNOS-luciferase activity and endogenous reactive nitrogen species were determined in transfected PYS-2 (mouse teratocarcinoma) cells exposed to hyperglycemia (450 mg/dl glucose). Results Hyperglycemia increased iNOS mRNA and SP600125, a potent JNK1/2 inhibitor, abolished this effect. Hyperglycemia increased iNOS-luciferase activities and SP600125 blocked this effect. Diabetes increased iNOS mRNA and jnk2 gene deletion abrogated this effect. Correlated with iNOS gene induction, both hyperglycemia in vitro and diabetes in vivo enhanced the production of reactive nitrogen species and increased protein nitrosylation. jnk2 gene deletion blocked diabetes-induced protein nitrosylation. Conclusion JNK1/2 activation mediates hyperglycemia-induced iNOS gene expression and consequent nitrosative stress in diabetic embryopathy. PMID:20541731

  15. Rapid NOS-1-derived nitric oxide and peroxynitrite formation act as signaling agents for inducible NOS-2 expression in vascular smooth muscle cells.

    PubMed

    Scheschowitsch, Karin; de Moraes, João Alfredo; Sordi, Regina; Barja-Fidalgo, Christina; Assreuy, Jamil

    2015-10-01

    Septic vascular dysfunction is characterized by hypotension and hyporeactivity to vasoconstrictors and nitric oxide (NO), reactive oxygen species and peroxynitrite have a prominent role in this condition. However, the mechanism whereby the vascular dysfunction is initiated is poorly understood. Based on previous studies of our group and the literature,we hypothesize that constitutive nitric oxide synthases (c-NOS) and peroxynitrite may play a role in the development of septic vascular dysfunction. Bacterial lipopolysaccharide (LPS) and interferon-γ (IFN) were used to stimulate rat aorta smooth muscle cells (A7r5) and rat aorta slices. This stimulation led to a rapid (within minutes) production of NO and superoxide anion, which led to peroxynitrite formation. When this rapid initial burst was reduced, through the inhibition of c-NOS and NADPH oxidases (NOX) or the scavenging of NO and superoxide the NF-κB activation, NOS-2 expression and nitrite production were significantly attenuated. Although vascular smooth muscle cells express both c-NOS isoforms, gene knockdown revealed that only NOS-1-dependent NO and peroxynitrite formation are important for the later NOS-2 expression. Similar findings were obtained by knockdown NOX-1 gene, one source of superoxide for peroxynitrite formation. Taking together, we show that smooth muscle cell activation by LPS/IFN leads to a rapid formation of NOS-1-derived NO and NOX-1-derived superoxide, forming peroxynitrite; and that this species act as a trigger for NOS-2 expression through NF-κB activation. Therefore, our findings suggest a critical role for NOS-1 and NOX-1 in the initiation of the vascular dysfunction associated with sepsis and septic shock. PMID:26253183

  16. 76 FR 18533 - Marine Mammals; File No. 15324

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... National Oceanic and Atmospheric Administration RIN 0648-XA341 Marine Mammals; File No. 15324 AGENCY... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15324 from the... to (301) 713- 0376, or by e-mail to NMFS.Pr1Comments@noaa.gov . Please include the File No. in...

  17. 75 FR 39915 - Marine Mammals; File No. 15483

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... National Oceanic and Atmospheric Administration RIN 0648-XX23 Marine Mammals; File No. 15483 AGENCY... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 15483 from the... include the File No. in the subject line of the email comment. Those individuals requesting a...

  18. 76 FR 18533 - Marine Mammals; File No. 15682

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... National Oceanic and Atmospheric Administration RIN 0648-XA342 Marine Mammals; File No. 15682 AGENCY... Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No... include the File No. in the subject line of the e-mail comment. Those individuals requesting a...

  19. 76 FR 70418 - Marine Mammals; File No. 16124

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... National Oceanic and Atmospheric Administration RIN 0648-XA817 Marine Mammals; File No. 16124 AGENCY... Protected Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 16124 from the...@noaa.gov . Please include File No. 16124 in the subject line of the email comment. Those...

  20. Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation

    PubMed Central

    Das, Amlan; Gopalakrishnan, Bhavani; Druhan, Lawrence J; Wang, Tse-Yao; De Pascali, Francesco; Rockenbauer, Antal; Racoma, Ira; Varadharaj, Saradhadevi; Zweier, Jay L; Cardounel, Arturo J; Villamena, Frederick A

    2014-01-01

    Background and Purpose Nitric oxide (NO) derived from eNOS is mostly responsible for the maintenance of vascular homeostasis and its decreased bioavailability is characteristic of reactive oxygen species (ROS)-induced endothelial dysfunction (ED). Because 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), a commonly used spin trap, can control intracellular nitroso-redox balance by scavenging ROS and donating NO, it was employed as a cardioprotective agent against ED but the mechanism of its protection is still not clear. This study elucidated the mechanism of protection by DMPO against SIN-1-induced oxidative injury to bovine aortic endothelial cells (BAEC). Experimental Approach BAEC were treated with SIN-1, as a source of peroxynitrite anion (ONOO−), and then incubated with DMPO. Cytotoxicity following SIN-1 alone and cytoprotection by adding DMPO was assessed by MTT assay. Levels of ROS and NO generation from HEK293 cells transfected with wild-type and mutant eNOS cDNAs, tetrahydrobiopterin bioavailability, eNOS activity, eNOS and Akt kinase phosphorylation were measured. Key Results Post-treatment of cells with DMPO attenuated SIN-1-mediated cytotoxicity and ROS generation, restoration of NO levels via increased in eNOS activity and phospho-eNOS levels. Treatment with DMPO alone significantly increased NO levels and induced phosphorylation of eNOS Ser1179 via Akt kinase. Transfection studies with wild-type and mutant human eNOS confirmed the dual role of eNOS as a producer of superoxide anion (O2−) with SIN-1 treatment, and a producer of NO in the presence of DMPO. Conclusion and Implications Post-treatment with DMPO of oxidatively challenged cells reversed eNOS dysfunction and could have pharmacological implications in the treatment of cardiovascular diseases. PMID:24405159

  1. The return of the Scarlet Pimpernel: cobalamin in inflammation II - cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS.

    PubMed

    Wheatley, Carmen

    2007-09-01

    The up-regulation of transcobalamins [hitherto posited as indicating a central need for cobalamin (Cbl) in inflammation], whose expression, like inducible nitric oxide synthase (iNOS), is Sp1- and interferondependent, together with increased intracellular formation of glutathionylcobalamin (GSCbl), adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl), may be essential for the timely promotion and later selective inhibition of iNOS and concordant regulation of endothelial and neuronal NOS (eNOS/nNOS.) Cbl may ensure controlled high output of nitric oxide (NO) and its safe deployment, because: (1) Cbl is ultimately responsible for the synthesis or availability of the NOS substrates and cofactors heme, arginine, BH(4) flavin adenine dinucleotide/flavin mononucleotide (FAD/FMN) and NADPH, via the far-reaching effects of the two Cbl coenzymes, methionine synthase (MS) and methylmalonyl CoA mutase (MCoAM) in, or on, the folate, glutathione, tricarboxylic acid (TCA) and urea cycles, oxidative phosphorylation, glycolysis and the pentose phosphate pathway. Deficiency of any of theNOS substrates and cofactors results in 'uncoupled' NOS reactions, decreasedNO production and increased or excessive O(2) (-), H(2)O(2), ONOO(-) and other reactive oxygen species (ROS), reactive nitric oxide species (RNIS) leading to pathology. (2) Cbl is also the overlooked ultimate determinant of positive glutathione status, which favours the formation of more benign NO species, s-nitrosothiols, the predominant form in which NO is safely deployed. Cbl status may consequently act as a 'back-up disc' that ensures the active status of antioxidant systems, as well as reversing and modulating the effects of nitrosylation in cell signal transduction.New evidence shows that GSCbl can significantly promote iNOS/ eNOS NO synthesis in the early stages of inflammation, thus lowering high levels of tumour necrosis factor-a that normally result in pathology, while existing evidence shows that in extreme

  2. The return of the Scarlet Pimpernel: cobalamin in inflammation II — cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS

    PubMed Central

    Wheatley, Carmen

    2007-01-01

    The up-regulation of transcobalamins [hitherto posited as indicating a central need for cobalamin (Cbl) in inflammation], whose expression, like inducible nitric oxide synthase (iNOS), is Sp1- and interferondependent, together with increased intracellular formation of glutathionylcobalamin (GSCbl), adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl), may be essential for the timely promotion and later selective inhibition of iNOS and concordant regulation of endothelial and neuronal NOS (eNOS/nNOS.) Cbl may ensure controlled high output of nitric oxide (NO) and its safe deployment, because: (1) Cbl is ultimately responsible for the synthesis or availability of the NOS substrates and cofactors heme, arginine, BH4 flavin adenine dinucleotide/flavin mononucleotide (FAD/FMN) and NADPH, via the far-reaching effects of the two Cbl coenzymes, methionine synthase (MS) and methylmalonyl CoA mutase (MCoAM) in, or on, the folate, glutathione, tricarboxylic acid (TCA) and urea cycles, oxidative phosphorylation, glycolysis and the pentose phosphate pathway. Deficiency of any of theNOS substrates and cofactors results in ‘uncoupled’ NOS reactions, decreasedNO production and increased or excessive O2−, H2O2, ONOO− and other reactive oxygen species (ROS), reactive nitric oxide species (RNIS) leading to pathology. (2) Cbl is also the overlooked ultimate determinant of positive glutathione status, which favours the formation of more benign NO species, s-nitrosothiols, the predominant form in which NO is safely deployed. Cbl status may consequently act as a ‘back-up disc’ that ensures the active status of antioxidant systems, as well as reversing and modulating the effects of nitrosylation in cell signal transduction.New evidence shows that GSCbl can significantly promote iNOS/ eNOS NO synthesis in the early stages of inflammation, thus lowering high levels of tumour necrosis factor-a that normally result in pathology, while existing evidence shows that in extreme

  3. 78 FR 17741 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... Release No. 68771 (January 30, 2013), 78 FR 8208 (February 5, 2013) (Notice of Filing and Immediate... Exchange Act Release Nos. 66871 (April 27, 2012) 77 FR 26323 (May 3, 2012) (File No.10- 206, In the Matter... Findings, Opinion, and Order of the Commission), and 67328 (June 29, 2012) 77 FR 40123 (July 6, 2012)...

  4. 78 FR 57191 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... restrictions. \\5\\ See Securities Exchange Act Release Nos. 66278 (January 30, 2012), 77 FR 5590 (February 3... on a pilot basis (SR-BX-2011-046), 66979 (May 14, 2012), 77 FR 29740 (May 18, 2012) (Notice of Filing...) (SR-BOX-2012-002), and 69054 (March 7, 2013), 78 FR 16025(March 13, 2013) (Notice of Filing...

  5. 78 FR 75644 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... Exchange Act Release Nos. 70472 (September 23, 2013), 78 FR 59738 (September 27, 2013)(Notice of Filing and Immediate Effectiveness of SR-PHLX-2013-93); 70470 (September 23, 2013) 78 FR 59740 (September 27, 2013)(Notice of Filing and Immediate Effectiveness of SR-NASDAQ-2013-117); and 70657 (October 10, 2013), 78...

  6. 78 FR 38416 - Self-Regulatory Organizations; Miami International Securities Exchange LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... Release Nos. 67754 (August 29, 2012), 77 FR 54629 (September 5, 2012) (Order approving SR-ISE-2012- 33) (``ISE filing''); 69633 (May 23, 2012), 78 FR 32498 (May 30, 2013) (SR-Phlx-2013-55) (``PHLX filing''); 68074 (October 19, 2012), 77 FR 65241 (October 25, 2012) (SR-CBOE-2012-92); and 68193 (November 8,...

  7. Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury

    PubMed Central

    Wu, Feng; Szczepaniak, William S.; Shiva, Sruti; Liu, Huanbo; Wang, Yinna; Wang, Ling; Wang, Ying; Kelley, Eric E.; Chen, Alex F.; Gladwin, Mark T.

    2014-01-01

    Microvascular barrier integrity is dependent on bioavailable nitric oxide (NO) produced locally by endothelial NO synthase (eNOS). Under conditions of limited substrate or cofactor availability or by enzymatic modification, eNOS may become uncoupled, producing superoxide in lieu of NO. This study was designed to investigate how eNOS-dependent superoxide production contributes to endothelial barrier dysfunction in inflammatory lung injury and its regulation. C57BL/6J mice were challenged with intratracheal LPS. Bronchoalveolar lavage fluid was analyzed for protein accumulation, and lung tissue homogenate was assayed for endothelial NOS content and function. Human lung microvascular endothelial cell (HLMVEC) monolayers were exposed to LPS in vitro, and barrier integrity and superoxide production were measured. Biopterin species were quantified, and coimmunoprecipitation (Co-IP) assays were performed to identify protein interactions with eNOS that putatively drive uncoupling. Mice exposed to LPS demonstrated eNOS-dependent increased alveolar permeability without evidence for altered canonical NO signaling. LPS-induced superoxide production and permeability in HLMVEC were inhibited by the NOS inhibitor nitro-l-arginine methyl ester, eNOS-targeted siRNA, the eNOS cofactor tetrahydrobiopterin, and superoxide dismutase. Co-IP indicated that LPS stimulated the association of eNOS with NADPH oxidase 2 (Nox2), which correlated with augmented eNOS S-glutathionylation both in vitro and in vivo. In vitro, Nox2-specific inhibition prevented LPS-induced eNOS modification and increases in both superoxide production and permeability. These data indicate that eNOS uncoupling contributes to superoxide production and barrier dysfunction in the lung microvasculature after exposure to LPS. Furthermore, the results implicate Nox2-mediated eNOS-S-glutathionylation as a mechanism underlying LPS-induced eNOS uncoupling in the lung microvasculature. PMID:25326583

  8. 75 FR 27335 - Combined Notice of Filings # 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ...: Portland General Electric Company. Description: Portland General Electric Company submits updated market... Corporation and BE KJ LLC's Supplement to Updated Market Power Analysis and Order Nos. 697 and 697-A... filing of qualification in ] the Forward Capacity Market for the 2013-2014 Capacity Commitment...

  9. 75 FR 70229 - Combined Notice of Filings No. 2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ..., November 17, 2010. Docket Numbers: RP10-1037-001. Applicants: Granite State Gas Transmission, Inc. Description: Granite State Gas Transmission, Inc. Filing Addressing Compliance Obligations in Docket Nos. RP10..., 2010. Docket Numbers: RP10-963-002. Applicants: Granite State Gas Transmission, Inc....

  10. Case File: The Spazzoids

    MedlinePlus

    ... classroom activities. More Related Links Healthy Schools Case file: The Spazzzoids Recommend on Facebook Tweet Share Compartir ... your classroom activities. More Related Links Healthy Schools File Formats Help: How do I view different file ...

  11. 76 FR 27684 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of a Proposed Rule Change To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010-01; SR-EDGX-2010... Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). \\4\\ The Commission... (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044;...

  12. 76 FR 74099 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ...), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS- 2010-014; SR-EDGA-2010-01; SR-EDGX-2010-01; SR-BX.... 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). \\5\\ The Commission approved the...), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044; SR-CBOE-2010-065;...

  13. 76 FR 74080 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ...), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS- 2010-014; SR-EDGA-2010-01; SR-EDGX-2010-01; SR-BX.... 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). \\5\\ The Commission approved the...), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044; SR-CBOE-2010-065;...

  14. 76 FR 51092 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... FR 34186 (June 16, 2010)(File Nos. SR-BATS-2010-014; SR-EDGA- 2010-01; SR-EDGX-2010-01; SR-BX-2010...- 061; SR-CHX-2010-10; SR-NSX-2010-05; and SR-CBOE-2010-047); 62251 (June 10, 2010), 75 FR 34183 (June... 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044;...

  15. 76 FR 51105 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

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    2011-08-17

    ..., 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR- EDGA-2010-01; SR-EDGX-2010-01; SR...- 2010-061; SR-CHX-2010-10; SR-NSX-2010-05; and SR-CBOE-2010-047) and 62251 (June 10, 2010), 75 FR 34183... (September 10, 2010), 75 FR 56618 (September 16, 2010) (File Nos. SR-BATS-2010-018; SR-BX-2010-044;...

  16. 43 CFR 4.1352 - Who may file; where to file; when to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Who may file; where to file; when to file... Indian Lands) § 4.1352 Who may file; where to file; when to file. (a) The applicant or operator may file... to file a timely request constitutes a waiver of the opportunity for a hearing before OSM makes...

  17. Common file formats.

    PubMed

    Leonard, Shonda A; Littlejohn, Timothy G; Baxevanis, Andreas D

    2007-01-01

    This appendix discusses a few of the file formats frequently encountered in bioinformatics. Specifically, it reviews the rules for generating FASTA files and provides guidance for interpreting NCBI descriptor lines, commonly found in FASTA files. In addition, it reviews the construction of GenBank, Phylip, MSF and Nexus files. PMID:18428774

  18. 76 FR 57776 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ..., 2011), 76 FR 1201 (January 7, 2011) (NASDAQ-2010-154) (notice of filing and immediate effectiveness). 2... the Investor Support Program, see Securities Exchange Act Release No. 63270 (November 8, 2010), 75 FR... Filing''). See also Securities Exchange Act Release Nos. 63414 (December 2, 2010), 75 FR 76505...

  19. 76 FR 74082 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ... Securities Exchange Act Release No. 62252 (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS...- 2010-047) and Securities Exchange Act Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010... Securities Exchange Act Release No. 62884 (September 10, 2010), 75 FR 56618 (September 16, 2010) (File...

  20. 76 FR 70784 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... as originally implemented, see Securities Exchange Act Release No. 63270 (November 8, 2010), 75 FR... Filing''). See also Securities Exchange Act Release Nos. 63414 (December 2, 2010), 75 FR 76505 (December...), 76 FR 1201 (January 7, 2011) (NASDAQ-2010-154) (notice of filing and immediate effectiveness);...

  1. 78 FR 17985 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ...), 78 FR 6382 (January 30, 2013) (SR-NASDAQ-2013-011) (notice of filing and immediate effectiveness of.... See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008)(SR-NASDAQ... 21, 2012), 78 FR 136 (January 2, 2013) (SR-NASDAQ-2012-143) (notice of filing and...

  2. 77 FR 40126 - Self-Regulatory Organizations; NASDAQ OMX Phlx, LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... Release Nos. 55153 (January 23, 2007), 72 FR 4553 (January 31, 2007) (SR-Phlx-2006-74) (notice of filing and approval order establishing Penny Pilot); 60873 (October 23, 2009), 74 FR 56675 (November 2, 2009...); 60966 (November 9, 2009), 74 FR 59331 (November 17, 2009) (SR-Phlx-2009-94) (notice of filing...

  3. 75 FR 41560 - Self-Regulatory Organizations; New York Stock Exchange LLC and NYSE Amex LLC; Notice of Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION [Release No. 34-64277; File Nos. SR-NYSE-2010-48 and SR-NYSEAMEX-2010- 61] Self-Regulatory Organizations; New York Stock Exchange LLC and NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to...

  4. 75 FR 1442 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of a Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... 5, 2008. See Securities Exchange Act Release Nos. 48013 (June 11, 2003), 68 FR 35933 (June 17, 2003) (SR-Phlx-2002-55) (notice of filing and order approving); 49801 (June 3, 2004), 69 FR 32652 (June 10, 2004) (SR- Phlx-2004-38) (notice of filing and immediate effectiveness); 51768 (May 31, 2005), 70...

  5. 78 FR 16898 - Self-Regulatory Organizations; the NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... COMMISSION Self-Regulatory Organizations; the NASDAQ Stock Market LLC; Notice of Filing and Immediate.... \\1\\ 15 U.S.C. 78s(b)(1). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the... Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008) (SR-NASDAQ-2008-026) (notice of filing...

  6. 77 FR 39781 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... Market LLC (``Nasdaq'').\\8\\ \\8\\ See Securities Exchange Act Release Nos. 65709 (November 8, 2011), 76 FR 70795 (November 15, 2011) (File No. SR-NYSE-2011-38); 65710 (November 8, 2011), 76 FR 70790 (November 15, 2011) (File No. SR-NYSEAmex-2011-55); 65708 (November 8, 2011), 76 FR 70799 (November 15, 2011)...

  7. Inducible nitric oxide synthase (iNOS) regulatory region variation in non-human primates

    PubMed Central

    Roodgar, Morteza; Ross, Cody T.; Kenyon, Nicholas J.; Marcelino, Gretchen; Smith, David Glenn

    2015-01-01

    Inducible nitric oxide synthase (iNOS) is an enzyme that plays a key role in intracellular immune response against respiratory infections. Since various species of nonhuman primates exhibit different levels of susceptibility to infectious respiratory diseases, and since variation in regulatory regions of genes is thought to play a key role in expression levels of genes, two candidate regulatory regions of iNOS were mapped, sequenced, and compared across five species of nonhuman primates: African green monkeys (chlorocebus sabeus), pig-tailed macaques (Macaca mulatta), cynomolgus macaques (Macaca fascicularis), Indian rhesus macaques (Macaca mulatta), and Chinese rhesus macaques (M. mulatta). In addition, we conducted an in silico analysis of the transcription factor binding sites associated with genetic variation in these two candidate regulatory regions across species. We found that only one of the two candidate regions showed strong evidence of involvement in iNOS regulation. Specifically, we found evidence of 13 conserved binding site candidates linked to iNOS regulation: AP-1, C/EBPB, CREB, GATA-1, GATA-3, NF-AT, NF-AT5, NF-κB, KLF4, Oct-1, PEA3, SMAD3, and TCF11. Additionally, we found evidence of interspecies variation in binding sites for several regulatory elements linked to iNOS (GATA-3, GATA-4, KLF6, SRF, STAT-1, STAT-3, OLF-1 and HIF-1) across species, especially in African green monkeys relative to other species. Given the key role of iNOS in respiratory immune response, the findings of this study might help guide the direction of future studies aimed to uncover the molecular mechanisms underlying the increased susceptibility of African green monkeys to several viral and bacterial respiratory infections. PMID:25675838

  8. Nitric Oxide Synthase Enzymes in the Airways of Mice Exposed to Ovalbumin: NOS2 Expression Is NOS3 Dependent

    PubMed Central

    Bratt, Jennifer M.; Williams, Keisha; Rabowsky, Michelle F.; Last, Michael S.; Franzi, Lisa M.; Last, Jerold A.; Kenyon, Nicholas J.

    2010-01-01

    Objectives and Design. The function of the airway nitric oxide synthase (NOS) isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent mechanism. Materials or Subjects. Mice from a C57BL/6 wild-type, NOS1−/−, NOS2−/−, and NOS3−/− genotypes were used. All mice strains were systemically sensitized and exposed to filtered air or ovalbumin (OVA) aerosol for two weeks to create a subchronic model of allergen-induced airway inflammation. Methods. We measured lung function, lung lavage inflammatory and airway epithelial goblet cell count, exhaled NO, nitrate and nitrite concentration, and airway NOS1, NOS2, and NOS3 protein content. Results. Deletion of NOS1 or NOS3 increases NOS2 protein present in the airway epithelium and smooth muscle of air-exposed animals. Exposure to allergen significantly reduced the expression of NOS2 protein in the airway epithelium and smooth muscle of the NOS3−/− strain only. This reduction in NOS2 expression was not due to the replacement of epithelial cells with goblet cells as remaining epithelial cells did not express NOS2. NOS1−/− animals had significantly reduced goblet cell metaplasia compared to C57Bl/6 wt, NOS2−/−, and NOS3−/− allergen-exposed mice. Conclusion. The airway epithelial and smooth muscle cells maintain a stable airway NO concentration under noninflammatory conditions. This “homeostatic” mechanism is unable to distinguish between NOS derived from the different constitutive NOS isoforms. NOS3 is essential for the expression of NOS2 under inflammatory conditions, while NOS1 expression contributes to allergen-induced goblet cell metaplasia. PMID:20953358

  9. On the selectivity of neuronal NOS inhibitors

    PubMed Central

    Pigott, B; Bartus, K; Garthwaite, J

    2013-01-01

    Background and Purpose Isoform-selective inhibitors of NOS enzymes are desirable as research tools and for potential therapeutic purposes. Vinyl-l-N-5-(1-imino-3-butenyl)-l-ornithine (l-VNIO) and Nω-propyl-l-arginine (NPA) purportedly have good selectivity for neuronal over endothelial NOS under cell-free conditions, as does N-[(3-aminomethyl)benzyl]acetamidine (1400W), which is primarily an inducible NOS inhibitor. Although used in numerous investigations in vitro and in vivo, there have been surprisingly few tests of the potency and selectivity of these compounds in cells. This study addresses this deficiency and evaluates the activity of new and potentially better pyrrolidine-based compounds. Experimental Approach The inhibitors were evaluated by measuring their effect on NMDA-evoked cGMP accumulation in rodent hippocampal slices, a response dependent on neuronal NOS, and ACh-evoked cGMP synthesis in aortic rings of the same animals, an endothelial NOS-dependent phenomenon. Key Results l-VNIO, NPA and 1400W inhibited responses in both tissues but all showed less than fivefold higher potency in the hippocampus than in the aorta, implying useless selectivity for neuronal over endothelial NOS at the tissue level. In addition, the inhibitors had a 25-fold lower potency in the hippocampus than reported previously, the IC50 values being approximately 1 μM for l-VNIO and NPA, and 150 μM for 1400W. Pyrrolidine-based inhibitors were similarly weak and nonselective. Conclusion and Implications The results suggest that l-VNIO, NPA and 1400W, as well as the newer pyrrolidine-type inhibitors, cannot be used as neuronal NOS inhibitors in cells without stringent verification. The identification of inhibitors with useable selectivity in cells and tissues remains an important goal. PMID:23072468

  10. The Complex Role of iNOS in Acutely-Rejecting Cardiac Transplants

    PubMed Central

    Pieper, Galen M.; Roza, Allan M.

    2008-01-01

    This review summarizes the evidence for a detrimental role of nitric oxide (NO) derived from inducible NO synthase (iNOS) and/or reactive nitrogen species such as peroxynitrite in acutely-rejecting cardiac transplants. In chronic cardiac transplant rejection, iNOS may have an opposing beneficial component. The purpose of this review is primarily to address issues related to acute rejection which is a recognized risk factor for chronic rejection. The evidence for a detrimental role is based upon strategies involving non-selective NOS inhibitors, NO neutralizers, selective iNOS inhibitors and iNOS gene deletion in rodent models of cardiac rejection. The review is discussed in the context of the impact on various components including graft survival, histological rejection and cardiac function which may contribute in toto to the process of graft rejection. Possible limitations of each strategy are discussed in order to understand better the variance in published findings including issues related to the potential importance of cell localization of iNOS expression. Finally, the concept of a dual role of NO and its down-stream product, peroxynitrite, in rejection vs. immune regulation is discussed. PMID:18291116

  11. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

    PubMed

    Datar, Sanjeev A; Gong, Wenhui; He, Youping; Johengen, Michael; Kameny, Rebecca J; Raff, Gary W; Maltepe, Emin; Oishi, Peter E; Fineman, Jeffrey R

    2016-07-01

    Associated abnormalities of the lymphatic circulation are well described in congenital heart disease. However, their mechanisms remain poorly elucidated. Using a clinically relevant ovine model of a congenital cardiac defect with chronically increased pulmonary blood flow (shunt), we previously demonstrated that exposure to chronically elevated pulmonary lymph flow is associated with: 1) decreased bioavailable nitric oxide (NO) in pulmonary lymph; and 2) attenuated endothelium-dependent relaxation of thoracic duct rings, suggesting disrupted lymphatic endothelial NO signaling in shunt lambs. To further elucidate the mechanisms responsible for this altered NO signaling, primary lymphatic endothelial cells (LECs) were isolated from the efferent lymphatic of the caudal mediastinal node in 4-wk-old control and shunt lambs. We found that shunt LECs (n = 3) had decreased bioavailable NO and decreased endothelial nitric oxide synthase (eNOS) mRNA and protein expression compared with control LECs (n = 3). eNOS activity was also low in shunt LECs, but, interestingly, inducible nitric oxide synthase (iNOS) expression and activity were increased in shunt LECs, as were total cellular nitration, including eNOS-specific nitration, and accumulation of reactive oxygen species (ROS). Pharmacological inhibition of iNOS reduced ROS in shunt LECs to levels measured in control LECs. These data support the conclusion that NOS signaling is disrupted in the lymphatic endothelium of lambs exposed to chronically increased pulmonary blood and lymph flow and may contribute to decreased pulmonary lymphatic bioavailable NO. PMID:27199125

  12. WOLF: FITS file processor

    NASA Astrophysics Data System (ADS)

    Shamir, Lior

    2012-12-01

    WOLF processes FITS files and generates photometry files, annotated JPGs, opacity maps, background, transient detection and luminance changes detection. This software was used to process data for the Night Sky Live project.

  13. Multifaceted NOS Instruction: Contextualizing Nature of Science with Documentary Films

    ERIC Educational Resources Information Center

    Bloom, Mark; Binns, Ian C.; Koehler, Catherine

    2015-01-01

    This research focuses on inservice science teachers' conceptions of nature of science (NOS) before and after a two-week intensive summer professional development (PD). The PD combined traditional explicit NOS instruction, numerous interactive interventions that highlighted NOS aspects, along with documentary films that portrayed NOS in context of…

  14. Standard interface file handbook

    SciTech Connect

    Shapiro, A.; Huria, H.C. )

    1992-10-01

    This handbook documents many of the standard interface file formats that have been adopted by the US Department of Energy to facilitate communications between and portability of, various large reactor physics and radiation transport software packages. The emphasis is on those files needed for use of the VENTURE/PC diffusion-depletion code system. File structures, contents and some practical advice on use of the various files are provided.

  15. Text File Display Program

    NASA Technical Reports Server (NTRS)

    Vavrus, J. L.

    1986-01-01

    LOOK program permits user to examine text file in pseudorandom access manner. Program provides user with way of rapidly examining contents of ASCII text file. LOOK opens text file for input only and accesses it in blockwise fashion. Handles text formatting and displays text lines on screen. User moves forward or backward in file by any number of lines or blocks. Provides ability to "scroll" text at various speeds in forward or backward directions.

  16. Text File Comparator

    NASA Technical Reports Server (NTRS)

    Kotler, R. S.

    1983-01-01

    File Comparator program IFCOMP, is text file comparator for IBM OS/VScompatable systems. IFCOMP accepts as input two text files and produces listing of differences in pseudo-update form. IFCOMP is very useful in monitoring changes made to software at the source code level.

  17. Carbon monoxide increases inducible NOS expression that mediates CO-induced myocardial damage during ischemia-reperfusion.

    PubMed

    Meyer, Grégory; André, Lucas; Kleindienst, Adrien; Singh, François; Tanguy, Stéphane; Richard, Sylvain; Obert, Philippe; Boucher, François; Jover, Bernard; Cazorla, Olivier; Reboul, Cyril

    2015-04-01

    We investigated the role of inducible nitric oxide (NO) synthase (iNOS) on ischemic myocardial damage in rats exposed to daily low nontoxic levels of carbon monoxide (CO). CO is a ubiquitous environmental pollutant that impacts on mortality and morbidity from cardiovascular diseases. We have previously shown that CO exposure aggravates myocardial ischemia-reperfusion (I/R) injury partly because of increased oxidative stress. Nevertheless, cellular mechanisms underlying cardiac CO toxicity remain hypothetical. Wistar rats were exposed to simulated urban CO pollution for 4 wk. First, the effects of CO exposure on NO production and NO synthase (NOS) expression were evaluated. Myocardial I/R was performed on isolated perfused hearts in the presence or absence of S-methyl-isothiourea (1 μM), a NOS inhibitor highly specific for iNOS. Finally, Ca(2+) handling was evaluated in isolated myocytes before and after an anoxia-reoxygenation performed with or without S-methyl-isothiourea or N-acetylcystein (20 μM), a nonspecific antioxidant. Our main results revealed that 1) CO exposure altered the pattern of NOS expression, which is characterized by increased neuronal NOS and iNOS expression; 2) cardiac NO production increased in CO rats because of its overexpression of iNOS; and 3) the use of a specific inhibitor of iNOS reduced myocardial hypersensitivity to I/R (infarct size, 29 vs. 51% of risk zone) in CO rat hearts. These last results are explained by the deleterious effects of NO and reactive oxygen species overproduction by iNOS on diastolic Ca(2+) overload and myofilaments Ca(2+) sensitivity. In conclusion, this study highlights the involvement of iNOS overexpression in the pathogenesis of simulated urban CO air pollution exposure. PMID:25595132

  18. 77 FR 36999 - Marine Mammals; File No. 16160

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... (77 FR 35657), authorizes takes of eight species of cetaceans in the inland waters of Washington State... National Oceanic and Atmospheric Administration RIN 0648-XA626 Marine Mammals; File No. 16160 AGENCY....nmfs.noaa.gov , and then selecting File No. 16160 from the list of available applications....

  19. 78 FR 15933 - Marine Mammals; File No. 17952

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... National Oceanic and Atmospheric Administration RIN 0648-XC554 Marine Mammals; File No. 17952 AGENCY... Species (APPS) home page, https://apps.nmfs.noaa.gov , and then selecting File No. 17952 from the list of... submitted by facsimile to (301) 713-0376, or by email to NMFS.Pr1Comments@noaa.gov . Please include the...

  20. Nitrous oxide reductase (nosZ) gene fragments differ between native and cultivated Michigan soils.

    PubMed

    Stres, Blaz; Mahne, Ivan; Avgustin, Gorazd; Tiedje, James M

    2004-01-01

    The effect of standard agricultural management on the genetic heterogeneity of nitrous oxide reductase (nosZ) fragments from denitrifying prokaryotes in native and cultivated soil was explored. Thirty-six soil cores were composited from each of the two soil management conditions. nosZ gene fragments were amplified from triplicate samples, and PCR products were cloned and screened by restriction fragment length polymorphism (RFLP). The total nosZ RFLP profiles increased in similarity with soil sample size until triplicate 3-g samples produced visually identical RFLP profiles for each treatment. Large differences in total nosZ profiles were observed between the native and cultivated soils. The fragments representing major groups of clones encountered at least twice and four randomly selected clones with unique RFLP patterns were sequenced to verify nosZ identity. The sequence diversity of nosZ clones from the cultivated field was higher, and only eight patterns were found in clone libraries from both soils among the 182 distinct nosZ RFLP patterns identified from the two soils. A group of clones that comprised 32% of all clones dominated the gene library of native soil, whereas many minor groups were observed in the gene library of cultivated soil. The 95% confidence intervals of the Chao1 nonparametric richness estimator for nosZ RFLP data did not overlap, indicating that the levels of species richness are significantly different in the two soils, the cultivated soil having higher diversity. Phylogenetic analysis of deduced amino acid sequences grouped the majority of nosZ clones into an interleaved Michigan soil cluster whose cultured members are alpha-Proteobacteria. Only four nosZ sequences from cultivated soil and one from the native soil were related to sequences found in gamma-Proteobacteria. Sequences from the native field formed a distinct, closely related cluster (D(mean) = 0.16) containing 91.6% of the native clones. Clones from the cultivated field were

  1. 43 CFR 4.1381 - Who may file; when to file; where to file.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... may file; when to file; where to file. (a) Any person who receives a written decision issued by OSM under 30 CFR 773.28 on a challenge to an ownership or control listing or finding may file a request for... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Who may file; when to file; where to...

  2. Catalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosL

    PubMed Central

    Ding, Wei; Ji, Xinjian; Li, Yongzhen; Zhang, Qi

    2016-01-01

    Catalytic promiscuity plays a key role in enzyme evolution and the acquisition of novel biological functions. Because of the high reactivity of radical species, in our view enzymes involving radical-mediated mechanisms could intrinsically be more prone to catalytic promiscuity. This mini-review summarizes the recent advances in the study of NosL, a radical S-adenosyl-L-methionine (SAM)-dependent L-tryptophan (L-Trp) lyase. We demonstrate here the interesting chemistry and remarkable catalytic promiscuity of NosL, and attempt to highlight the high evolvability of radical SAM enzymes and the potential to engineer these enzymes for novel and improved activities. PMID:27446906

  3. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Change in ownership of an index file. 516.163... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index... index file. (a) A holder may transfer ownership of a drug's index file to another person. (1) The...

  4. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Change in ownership of an index file. 516.163... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index... index file. (a) A holder may transfer ownership of a drug's index file to another person. (1) The...

  5. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Change in ownership of an index file. 516.163... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index... index file. (a) A holder may transfer ownership of a drug's index file to another person. (1) The...

  6. 21 CFR 516.163 - Change in ownership of an index file.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Change in ownership of an index file. 516.163... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index... index file. (a) A holder may transfer ownership of a drug's index file to another person. (1) The...

  7. EPA FACILITY POINT LOCATION FILES

    EPA Science Inventory

    Data includes locations of facilities from which pollutants are discharged. The epapoints.tar.gz file is a gzipped tar file of 14 Arc/Info export files and text documents. The .txt files define the attributes located in the INFO point coverage files. Projections are defined in...

  8. An evolutionarily ancient NO synthase (NOS) in shrimp.

    PubMed

    Wu, Chun-Hung; Siva, Vinu S; Song, Yen-Ling

    2013-11-01

    Nitric oxide (NO) is a well known essential molecule that is involved in multiple functions such as neuron transduction, cardiac disease, immune responses, etc.; nitric oxide synthase (NOS) is a critical enzyme that catalyzes the synthesis of it. A very few crustacean NOS molecules were biochemically characterized so far. In the present study, we cloned and characterized a NOS cDNA from haemocytes of tiger shrimp (Penaeus monodon) (PmNOS). The full-length of PmNOS cDNA contained 3997 bp, including a 5'UTR of 249 bp, ORF of 3582 bp and a 3'UTR of 166 bp. The putative peptide was 1193 amino acid residues in length, with an estimated molecular weight of 134.7 kDa and pI 6.7. Structurally, PmNOS contained oxygenase and reductase domains at N-terminal and C-terminal, respectively, and connected with a calmodulin binding motif. The deduced amino acid sequence of PmNOS shared 98% identical to the Chinese shrimp (Fenneropenaeus chinensis) NOS. Phylogenetically, PmNOS clustered with invertebrate NOS, but not clustered with iNOS, eNOS or nNOS found in vertebrates. PmNOS mRNA was expressed in many tissues or organs including thoracic and ventral nerves, midgut, gill, eyestalk, haemocytes, subcuticular epithelium and heart, but not found in hepatopancreas, muscle and lymphoid organ. But there was no significant difference in PmNOS mRNA expression after stimulation with LPS either by different concentration or time course or against CpG-ODN 2006. The enzyme activities of rPmNOS or crude homogenates from different tissues were detected, and were shown its highest activity in thoracic and ventral nerves, moderate in midgut and haemocytes but the lowest activity were seen in muscle. The addition of NOS antibody against NADPH binding domain leads to less activity which suggested that NADPH was an essential cofactor for PmNOS catalytic activity. The calcium dependency of PmNOS was ascertained using calmodulin inhibitor, Trifluroperazine. To confirm the population of haemocyte which

  9. Medical image file formats.

    PubMed

    Larobina, Michele; Murino, Loredana

    2014-04-01

    Image file format is often a confusing aspect for someone wishing to process medical images. This article presents a demystifying overview of the major file formats currently used in medical imaging: Analyze, Neuroimaging Informatics Technology Initiative (Nifti), Minc, and Digital Imaging and Communications in Medicine (Dicom). Concepts common to all file formats, such as pixel depth, photometric interpretation, metadata, and pixel data, are first presented. Then, the characteristics and strengths of the various formats are discussed. The review concludes with some predictive considerations about the future trends in medical image file formats. PMID:24338090

  10. 75 FR 52790 - Self-Regulatory Organizations; NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    ... through December 31, 2010. See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587... Pilot); 60874 (October 23, 2009), 74 FR 56682 (November 2, 2009) (SR-NASDAQ-2009-091) (notice of filing and immediate effectiveness expanding and extending Penny Pilot); 60965 (November 9, 2009), 74...

  11. 75 FR 71475 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ....\\8\\ \\8\\ Securities Exchange Act Release No. 51808 (June 9, 2005), 70 FR 37496 (June 29, 2005). By... Securities Exchange Act Release Nos. 63084 (October 13, 2010), 75 FR 64379 (October 19, 2010) (Notice of... (September 10, 2010), 75 FR 57092 (September 17, 2010) (Notice of Filing and Immediate Effectiveness...

  12. 75 FR 36458 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change, as Modified by Amendment Nos. 1 and 2, Related to the Price Improvement Mechanism June 17,...

  13. 78 FR 54294 - Investment Company Act Release No. 30679; File No. 812-14167

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... COMMISSION Investment Company Act Release No. 30679; File No. 812-14167 Franklin Templeton International... (``Commission''). ACTION: Notice of an application under section 6(c) of the Investment Company Act of 1940..., Investment Company Act Release Nos. 30105 (Jun. 18, 2012) (notice) and 30138 (Jul. 17, 2012)...

  14. 78 FR 28692 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... Securities Exchange Act Release No. 69511 (May 03, 2013), 78 FR 27271 (May 9, 2013) (Order Approving SR-BOX-2013-06). \\5\\ Id. \\6\\ Id. \\7\\ See Securities Exchange Act Release Nos. 69154 (March 15, 2013), 78 FR..., 2013), 78 FR 19562 (April 1, 2013) (Notice of Filing and Immediate Effectiveness of SR-BOX-2013-18)...

  15. 75 FR 65692 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Release Nos. 60694 (September 18, 2009), 74 FR 49048 (September 25, 2009) (SR-Phlx-2009-65) (order approving); and 61630 (March 2, 2010), 75 FR 11211 (March 10, 2010) (SR-Phlx-2010-26) (notice of filing and... Exchange added $5 to the listed strike prices of $2, $3 and $4 to account for the overlap with the...

  16. 77 FR 19400 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Release No. 65565 (October 14, 2011), 76 FR 65255 (October 20, 2011) (SR-EDGX-2011-33). \\5\\ See Securities Exchange Act Release No. 66171 (January 17, 2012), 77 FR 3297 (January 23, 2012) (File Nos. SR-EDGA-2011-34... NYSE Euronext and Deutsche B rse AG Will Not Become Effective March 26, 2012 Pursuant to Section...

  17. 77 FR 19391 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Release No. 65564 (October 14, 2011), 76 FR 65264 (October 20, 2011) (SR-EDGA-2011-34). \\5\\ See Securities Exchange Act Release No. 66171 (January 17, 2012), 77 FR 3297 (January 23, 2012) (File Nos. SR-EDGA-2011-34... NYSE Euronext and Deutsche B rse AG Will Not Become Effective March 26, 2012. Pursuant to Section...

  18. 77 FR 15417 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    .... 56955 (December 13, 2007); 72 FR 71979 (December 19, 2007) (SR-ISE-2007-101). On December 23, 2008, the... (December 22, 2008); 73 FR 79954 (December 30, 2008) (SR-ISE-2008-85). On May 7, 2009, Direct Edge's direct... Release No. 60651 (September 11, 2009); 74 FR 47827 (September 17, 2009) (File Nos. 10-193 and 10-194)....

  19. 76 FR 44388 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ...), 75 FR 47335 (August 5, 2010) (SR-BATS-2010-020) (notice of filing and immediate effectiveness...), 76 FR 8793 (February 15, 2011) (SR-Phlx-2010-183) (order granting approval of expansion of short term... Exchange Act Release Nos. 64009 (March 2, 2011), 76 FR 12771 (March 8, 2011) (SR-BX-2011-014) (notice...

  20. 76 FR 1208 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... Release Nos. 62663 (August 9, 2010), 75 FR 49543 (August 13, 2010) (SR-NASDAQ-2010-077) (order approving... (August 10, 2010), 75 FR 50020 (August 16, 2010) (SR-EDGA-2010-06) (order approving fees for both 1G and... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate...

  1. 76 FR 39463 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... information on the Obligation Warehouse service, see Exchange Act Release 63588 (December 21, 2010), 75 FR.... SR-NSCC-2010-01], 75 FR 10542 (March 8, 2010). \\6\\ In order to distinguish securities transfers from... NSCC, see Exchange Act Release No. 40179 (July 8, 1998), 63 FR 38221 (July 15, 1998) (File Nos....

  2. 78 FR 76691 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-18

    ... Securities Exchange Findings, Opinion, and Order of the Commission), 67328 (June 29, 2012) 77 FR 40123 (July...-021) and 69789 (June 18, 2013) 78 FR 37854 (June 24, 2013) (SR-BOX-2013-31). The extension of the.... See Securities Exchange Act Release Nos. 66871 (April 27, 2012) 77 FR 26323 (May 3, 2012) (File...

  3. 77 FR 61036 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ... COMMISSION Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and... intermarket linkage rules.\\8\\ \\6\\ See Securities Exchange Act Release Nos. 57812 (May 12, 2008), 73 FR 28846 (May 19, 2008) (SR-ISE-2008-50); 58038 (June 26, 2008), 73 FR 38261 (June July 3, 2008)...

  4. 76 FR 22425 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-21

    ... COMMISSION Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and... Exchange's Schedule of Fees. See Securities Exchange Act Release Nos. 61869 (April 7, 2010), 75 FR 19449 (April 14, 2010) (SR-ISE-2010-25), 62048 (May 6, 2010), 75 FR 26830 (May 12, 2010)...

  5. 77 FR 35723 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... COMMISSION Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and... and proposes to eliminate it. \\3\\ See Exchange Act Release Nos. 34-54751 (November 14, 2006), 71 FR 67667 (November 22, 2006) (SR-ISE-2006-56); 55247 (February 6, 2007), 72 FR 7099 (February 14, 2007)...

  6. 76 FR 50805 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... COMMISSION Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and... Fees. See Securities Exchange Act Release Nos. 61869 (April 7, 2010), 75 FR 19449 (April 14, 2010) (SR-ISE-2010-25), 62048 (May 6, 2010), 75 FR 26830 (May 12, 2010) (SR-ISE-2010-43), 62282 (June 11,...

  7. 76 FR 19160 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    .... \\3\\ See Securities Exchange Act Release No. 35993 (July 19, 1995), 60 FR 38073 (July 25, 1995... also Exchange Act Release No. 52893 (December 5, 2005) 70 FR 73488 (December 12, 2005) (a rule change... Exchange Act Release No. 40662 (November 12, 1998), 63 FR 64297 (November 19, 1998) (approving File Nos....

  8. 76 FR 19165 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    .... \\3\\ See Securities Exchange Act Release No. 35993 (July 19, 1995), 60 FR 38073 (July 25, 1995... Exchange Act Release No. 52986 (December 20, 2005) 70 FR 76897 (December 28, 2005) (a rule change to allow... Exchange Act Release No. 40662 (November 12, 1998), 63 FR 64297 (November 19, 1998) (approving File Nos....

  9. 76 FR 20764 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... option classes. See Securities Exchange Act Release No. 35993 (July 19, 1995), 60 FR 38073 (July 25, 1995... (November 12, 1998), 63 FR 64297 (November 19, 1998) (approving File Nos. SR-Amex- 98-21, SR-CBOE-98-29, SR... Strike Price Program. See Securities Exchange Act Release No. 52960 (December 15, 2005), 70 FR...

  10. 77 FR 65241 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-25

    ... non-Weekly options expire. \\6\\ See Securities Exchange Act Release Nos. 67754 (August 29, 2012), 77 FR...) 77 FR 54635 (September 5, 2012) (order approving SR-Phlx-2012-78) (``Phlx filing''). ISE and Phlx... Exchange is making a distinction between initiating series and cloning series. The Exchange and...

  11. 76 FR 76472 - Self-Regulatory Organizations; NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008) (SR-NASDAQ-2008-026) (notice of filing and immediate effectiveness establishing Penny Pilot); 60874 (October 23, 2009), 74 FR... and extending Penny Pilot); 60965 (November 9, 2009), 74 FR 59292 (November 17, 2009)...

  12. 77 FR 2335 - Self-Regulatory Organizations; NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... Release No. 61358 (January 14, 2010), 75 FR 3594 (January 21, 2010) (Concept Release on Equity Market... December 31, 2011. See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4... (October 23, 2009), 74 FR 56682 (November 2, 2009)(SR-NASDAQ-2009-091)(notice of filing and...

  13. 75 FR 65693 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Act Release Nos. 59277 (November 6, 2009), 74 FR 59277 (November 17, 2009 (SR-NASDAQ-2009-099) (order approving); and 61736 (March 18, 2010), 75 FR 14229 (March 24, 2010) (SR-NASDAQ-2010-038) (notice of filing... Change by the NASDAQ Stock Market, LLC To Expand the $0.50 Strike Price Program Date: October 20,...

  14. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... file electronically under 11 CFR 104.18, may file 24-hour reports using the Commission's website's on... to be filed under 11 CFR parts 101, 102, 104, 105, 107, 108, and 109, and any modifications or... required by 11 CFR part 105, by the close of business on the prescribed filing date. (b) Timely filed....

  15. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... file electronically under 11 CFR 104.18, may file 24-hour reports using the Commission's website's on... to be filed under 11 CFR parts 101, 102, 104, 105, 107, 108, and 109, and any modifications or... required by 11 CFR part 105, by the close of business on the prescribed filing date. (b) Timely filed....

  16. 75 FR 30017 - Electronic Tariff Filings; Notice of Posting Regarding Filing Procedures for Electronically Filed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... Energy Regulatory Commission Electronic Tariff Filings; Notice of Posting Regarding Filing Procedures for Electronically Filed Tariffs May 21, 2010. Take Notice that the attached document ``Filing Procedures For Electronically Filed Tariffs, Rate Schedules And Jurisdictional Agreements'' has been posted on the eTariff...

  17. 15 CFR Supplement Nos. 3-4 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 3-4 to Part 742 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos. 3-4 to Part 742...

  18. Hopper File Management Tool

    SciTech Connect

    Long, J W; O'Neill, N J; Smith, N G; Springmeyer, R R; Remmele, S; Richards, D A; Southon, J

    2004-11-15

    Hopper is a powerful interactive tool that allows users to transfer and manipulate files and directories by means of a graphical user interface. Users can connect to and manage resources using the major file transfer protocols. Implemented in Java, Hopper can be run almost anywhere: from an individual's desktop machine to large production machines. In a high-performance computing environment, managing files can become a difficult and time-consuming task that distracts from scientific work. Users must deal with multiple file transfer protocols, transferring enormous amounts of files between computer platforms, repeated authentication, organizing massive amounts of data, and other detailed but necessary tasks. This is often accomplished with a set of several different tools, each with its own interface and idiosyncrasies. Our goal is to develop tools for a more automated approach to file management that substantially improves users' ability to transfer, organize, search, and operate on collections of files. This paper describes the Hopper tool for advanced file management, including the software architecture, the functionality, and the user interface.

  19. JENDL Dosimetry File 99.

    Energy Science and Technology Software Center (ESTSC)

    2001-01-22

    Version 00 JENDL/D-99 contains information for 47 nuclides and 67 reactions in the SAND-II group structure (although it was observed by RSICC that not all of the processed files are in the SAND-II group structure) and as 0K preprocessed pointwise files.

  20. NASA Uniform Files Index

    NASA Technical Reports Server (NTRS)

    1987-01-01

    This handbook is a guide for the use of all personnel engaged in handling NASA files. It is issued in accordance with the regulations of the National Archives and Records Administration, in the Code of Federal Regulations Title 36, Part 1224, Files Management; and the Federal Information Resources Management Regulation, Subpart 201-45.108, Files Management. It is intended to provide a standardized classification and filing scheme to achieve maximum uniformity and ease in maintaining and using agency records. It is a framework for consistent organization of information in an arrangement that will be useful to current and future researchers. The NASA Uniform Files Index coding structure is composed of the subject classification table used for NASA management directives and the subject groups in the NASA scientific and technical information system. It is designed to correlate files throughout NASA and it is anticipated that it may be useful with automated filing systems. It is expected that in the conversion of current files to this arrangement it will be necessary to add tertiary subjects and make further subdivisions under the existing categories. Established primary and secondary subject categories may not be changed arbitrarily. Proposals for additional subject categories of NASA-wide applicability, and suggestions for improvement in this handbook, should be addressed to the Records Program Manager at the pertinent installation who will forward it to the NASA Records Management Office, Code NTR, for approval. This handbook is issued in loose-leaf form and will be revised by page changes.

  1. 21 CFR 516.147 - Refuse to file a request for addition to the index.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Refuse to file a request for addition to the index... SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.147 Refuse to file a request for addition to the index. (a) If a request for addition to the index contains all of...

  2. Register file soft error recovery

    DOEpatents

    Fleischer, Bruce M.; Fox, Thomas W.; Wait, Charles D.; Muff, Adam J.; Watson, III, Alfred T.

    2013-10-15

    Register file soft error recovery including a system that includes a first register file and a second register file that mirrors the first register file. The system also includes an arithmetic pipeline for receiving data read from the first register file, and error detection circuitry to detect whether the data read from the first register file includes corrupted data. The system further includes error recovery circuitry to insert an error recovery instruction into the arithmetic pipeline in response to detecting the corrupted data. The inserted error recovery instruction replaces the corrupted data in the first register file with a copy of the data from the second register file.

  3. NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage.

    PubMed

    Kleinschnitz, Christoph; Mencl, Stine; Kleikers, Pamela Wm; Schuhmann, Michael K; G López, Manuela; Casas, Ana I; Sürün, Bilge; Reif, Andreas; Schmidt, Harald Hhw

    2016-09-01

    Promising results have been reported in preclinical stroke target validation for pharmacological principles that disrupt the N-methyl-D-aspartate receptor-post-synaptic density protein-95-neuronal nitric oxide synthase complex. However, post-synaptic density protein-95 is also coupled to potentially neuroprotective mechanisms. As post-synaptic density protein-95 inhibitors may interfere with potentially neuroprotective mechanisms and sufficient validation has often been an issue in translating basic stroke research, we wanted to close that gap by comparing post-synaptic density protein-95 inhibitors with NOS1(-/-) mice and a NOS inhibitor. We confirm the deleterious role of NOS1 in stroke both in vivo and in vitro, but find three pharmacological post-synaptic density protein-95 inhibitors to be therapeutically ineffective. PMID:27354091

  4. Registered File Support for Critical Operations Files at SIRTF

    NASA Astrophysics Data System (ADS)

    Turek, G.; Handley, T.; Jacobson, J.; Rector, J.

    The SIRTF Science Center's (SSC) Science Operations System (SOS) has to contend with nearly one hundred critical operations files via comprehensive file management services. The management is accomplished via the registered file system (otherwise known as TFS) which manages these files in a registered file repository composed of a virtual file system accessible via a TFS server and a file registration database. The TFS server provides controlled, reliable, and secure file transfer and storage by registering all file transactions and meta-data in the file registration database. An API is provided for application programs to communicate with TFS servers and the repository. A command line client implementing this API has been developed as a client tool. This paper describes the architecture, current implementation, and more importantly, the evolution of these services based on evolving community use cases and emerging information system technology.

  5. SS focused technology: Gateways and NOS's

    NASA Technical Reports Server (NTRS)

    Hartenstein, R.

    1985-01-01

    The extensions and enhancements of the fiber optic data bus technology supported by the Space Station Focused Technology Program are discussed. This includes the operating software for the network called the Network Operating System (NOS); gateways and bridges for multiple network topologies; and very large scale topology implimentations to shrink the size and power of the Bus Interface Unit (BIU) down to more manageable dimensions. CMOS is being investigated for the lower speed (parallel) logic. Gallium arsendide is being studied for the high speed (serial) logic.

  6. Expression of the nos gene and firefly flashing: a test of the nitric-oxide-mediated flash control model.

    PubMed

    Ohtsuki, Hajime; Yokoyama, Jun; Ohba, Nobuyoshi; Ohmiya, Yoshihiro; Kawata, Masakado

    2014-01-01

    Fireflies (Coleoptera: Lampyridae) emit various types of light that differ among species and populations of the same species. Their lights are assumed to be biological properties that play important ecological and evolutionary roles. Some species in the Lampyridae emit periodic luminescence, the patterns of which are characterized by species-specific intervals. In previous work, it was predicted that the nitric oxide (NO) regulates the oxygen supply required for the bioluminescence reaction of fireflies. Here, the expression of the NO synthase (NOS) mRNA in some fireflies was examined to verify the predictive model of nitric-oxide-mediated flash control in these insects. The expression of the nos gene in the lantern organ was observed not only in nocturnal flashing species but also in diurnal non-flashing species. It was shown that the expression levels of nos were higher in the lantern of Luciola cruciata (Motschulsky) larvae, which that emits continuous light, than in other body parts, although expression in the lantern of the adults, who flash periodically, was not high. Furthermore, there was no significant difference in expression levels among adults of Luciola cruciata characterized by different flashing intervals. The data do not support the model of an NO-mediated flash control mechanism, during which oxygen becomes available for the luciferin-luciferase reaction through NO-mediated inhibition of mitochondrial respiration. It is also indicated that flash patterns do not co-vary with NOS production. However, high nos expression in the larval lantern suggests that NO may play a role in producing continuous light by functioning as a neurotransmitter signal for bioluminescence. PMID:25373203

  7. The dual role of iNOS in cancer☆

    PubMed Central

    Vanini, Frederica; Kashfi, Khosrow; Nath, Niharika

    2015-01-01

    Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous free radical whose predominant functions is that of a messenger through cGMP. In mammals, NO is synthesized by the enzyme nitric oxide synthase (NOS) of which there are three isoforms. Neuronal (nNOS, NOS1) and endothelial (eNOS, NOS3) are constitutive calcium-dependent forms of the enzyme that regulate neural and vascular function respectively. The third isoform (iNOS, NOS2), is calcium-independent and is inducible. In many tumors, iNOS expression is high, however, the role of iNOS during tumor development is very complex and quite perplexing, with both promoting and inhibiting actions having been described. This review will aim to summarize the dual actions of iNOS-derived NO showing that the microenvironment of the tumor is a contributing factor to these observations and ultimately to cellular outcomes. PMID:26335399

  8. Ivabradine Prevents Low Shear Stress Induced Endothelial Inflammation and Oxidative Stress via mTOR/eNOS Pathway

    PubMed Central

    Li, Bing; Zhang, Junxia; Wang, Zhimei; Chen, Shaoliang

    2016-01-01

    Ivabradine not only reduces heart rate but has other cardiac and vascular protective effects including anti-inflammation and anti-oxidation. Since endothelial nitric oxide synthase (eNOS) is a crucial enzyme in maintaining endothelial activity, we aimed to investigate the impact of ivabradine in low shear stress (LSS) induced inflammation and endothelial injury and the role of eNOS played in it. Endothelial cells (ECs) were subjected to LSS at 2dyne/cm2, with 1 hour of ivabradine (0.04μM) or LY294002 (10μM) pre-treatment. The mRNA expression of IL-6, VCAM-1 along with eNOS were measured by QPCR. Reactive oxygen species (ROS) was detected by dihydroethidium (DHE) and DCF, and protein phosphorylation was detected by western blot. It demonstrated that ivabradine decreased LSS induced inflammation and oxidative stress in endothelial cells. Western blot showed reduced rictor and Akt-Ser473 as well as increased eNOS-Thr495 phosphorylation. However, mTORC1 pathway was only increased when LSS applied within 30 minutes. These effects were reversed by ivabradine. It would appear that ivabradine diminish ROS generation by provoking mTORC2/Akt phosphorylation and repressing mTORC1 induced eNOS-Thr495 activation. These results together suggest that LSS induced endothelial inflammation and oxidative stress are suppressed by ivabradine via mTORC2/Akt activation and mTORC1/eNOS reduction. PMID:26890696

  9. MAWST file generator (MFG)

    SciTech Connect

    Henriksen, P.W.; Hurdle, S.; Hafer, J.F.

    1993-12-01

    The software program MAWST was developed as a tool to deal with common materials accounting problems. The key to successful usage of this program is in the generation of input files for measurement values, measurement errors, and measurement methods. The program MFG was developed as an aid to creating input files for MAWST. MFG contains three commonly used measurements -- nondestructive assay, (G-T)*C, and V*C -- and a GENERIC measurement as models for data entry for the measurement value file. Sufficient data is collected from the user to produce the measurement error and measurement method files. This report is written as a tutorial presenting and explaining all the options available in MFG by giving examples of execution and the resulting screens that MFG produces.

  10. Specifying PDD-NOS: A Comparison of PDD-NOS, Asperger Syndrome, and Autism

    ERIC Educational Resources Information Center

    Walker, Darlene R.; Thompson, Ann; Zwaigenbaum, Lonnie; Goldberg, Jeremy; Bryson, Susan E.; Mahoney, William J.; Strawbridge, Christina P.; Szatmari, Peter

    2004-01-01

    Objective: To describe the clinical characteristics of children given a diagnosis of pervasive developmental disorder-not otherwise specified (PDD-NOS) by expert clinicians and to compare these to the clinical characteristics of children given a diagnosis of autism and Asperger syndrome (AS). Method: Two hundred sixteen children with autism, 33…

  11. 78 FR 30872 - Marine Mammals; File Nos. 14451, 14353, and 13846

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ..., 2013, notice was published in the Federal Register (78 FR 2955) that the subject amendment requests had..., issued on July 14, 2010 (75 FR 43151), authorizes the permit holder, Joseph Mobley, Jr., to study... Insular Hawaiian false killer whales under the ESA. Permit No. 14353, issued on July 14, 2010 (75 FR...

  12. 75 FR 43150 - Marine Mammals; File Nos. 10018, 13846, 14451, 14585, 14599, 14122, 14296, and 14353

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... INFORMATION: On November 12, 2009, notice was published in the Federal Register (74 FR 58243) that requests... amendment to Permit No. 10018, originally issued on June 18, 2008 (73 FR 36042). Permit No. 10018 authorized Dr. Cartwright to conduct humpback whale (Megaptera novaeangliae) research, consisting of...

  13. 77 FR 35657 - Marine Mammals; File Nos. 16163, 16160, and 15569

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... FR 213) that a request for permits to conduct research on marine mammals had been submitted by the... suction- cup tagged. Ultrasound sampling will be directed at killer whales including the Southern Resident stock. Active acoustic playback studies will be directed at Southern Resident killer whales. Import...

  14. 75 FR 39206 - Marine Mammals; File Nos. 87-1851 and 555-1870

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... No. 87-1851- 02, issued December 28, 2009 (75 FR 106) and Permit No. 555-1870-01, issued February 24, 2010 (75 FR 11132) is requested under the authority of the Marine Mammal Protection Act of 1972, as... hereby given that Daniel P. Costa, PhD, University of California at Santa Cruz, Long Marine...

  15. 77 FR 12010 - Marine Mammals; File Nos. 1076-1789 and 14502

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ... (72 FR 13092), authorized the receipt, import and export of marine mammal specimens (cetaceans and... June 17, 2011 (72 FR 13092), authorized the importation of samples from Risso's (Grampus griseus..., Colorado 80234 (Kristi West, Ph.D., Principal Investigator) and Russell Fielding, Ph.D., Department...

  16. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... file electronically under 11 CFR 104.18, may file 24-hour reports using the Commission's website's on... to be filed under 11 CFR parts 101, 102, 104, 105, 107, 108, and 109, and any modifications or...., Washington, DC 20510 as required by 11 CFR part 105, by the close of business on the prescribed filing...

  17. Converting CSV Files to RKSML Files

    NASA Technical Reports Server (NTRS)

    Trebi-Ollennu, Ashitey; Liebersbach, Robert

    2009-01-01

    A computer program converts, into a format suitable for processing on Earth, files of downlinked telemetric data pertaining to the operation of the Instrument Deployment Device (IDD), which is a robot arm on either of the Mars Explorer Rovers (MERs). The raw downlinked data files are in comma-separated- value (CSV) format. The present program converts the files into Rover Kinematics State Markup Language (RKSML), which is an Extensible Markup Language (XML) format that facilitates representation of operations of the IDD and enables analysis of the operations by means of the Rover Sequencing Validation Program (RSVP), which is used to build sequences of commanded operations for the MERs. After conversion by means of the present program, the downlinked data can be processed by RSVP, enabling the MER downlink operations team to play back the actual IDD activity represented by the telemetric data against the planned IDD activity. Thus, the present program enhances the diagnosis of anomalies that manifest themselves as differences between actual and planned IDD activities.

  18. 76 FR 62798 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... filing per 154.402: GSS LSS SS-2 S-2 2011 TGPL ACA Tracker Filing to be effective 10/1/2011. Filed Date... Tracker Filing to be effective 11/1/ 2011. Filed Date: 09/30/2011. Accession Number: 20110930-5048.... Description: Texas Gas Transmission, LLC submits tariff filing per 154.403(d)(2): 2011 Fuel Tracker Filing...

  19. Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress: A mechanism for uric acid-induced endothelial dysfunction

    PubMed Central

    LI, PENG; ZHANG, LINA; ZHANG, MEI; ZHOU, CHANGYONG; LIN, NAN

    2016-01-01

    The mechanism by which hyperuricemia induced-endothelial dysfunction contributes to cardiovascular diseases (CVDs) is not yet fully understood. In the present study, we used uric acid (UA) to trigger endothelial dysfunction in cultured endothelial cells, and investigated the effects of induced reactive oxygen species (ROS) generation, endoplasmic reticulum (ER) stress induction, and the protein kinase C (PKC)-dependent endothelial nitric oxide synthase (eNOS) signaling pathway. Human umbilical vein endothelial cells (HUVECs) were incubated with 6, 9 or 12 mg/dl UA, ROS scavenger polyethylene glycol-superoxide dismutase (PEG-SOD), ER stress inhibitor 4-phenylbutyric acid (4-PBA), and PKC inhibitor polymyxin B for 6–48 h. Nitric oxide (NO) production, eNOS activity, intracellular ROS, ER stress levels, and the interaction between eNOS and calmodulin (CaM) and cytosolic calcium levels were assessed using fluorescence microscopy and western blot analysis. Apoptosis was assessed by annexin V staining. UA increased HUVEC apoptosis and reduced eNOS activity and NO production in a dose- and time-dependent manner. Intracellular ROS was elevated after 3 h, while ER stress level increased after 6 h. UA did not alter intracellular Ca2+, CaM, or eNOS concentration, or eNOS Ser1177 phosphorylation. However, PKC-dependent eNOS phosphorylation at Thr495 was greatly enhanced, and consequently interaction between eNOS and CaM was reduced. Cellular ROS depletion, ER stress inhibition and PKC activity reduction inhibited the effect of UA on eNOS activity, NO release and apoptosis in HUVECs. Thus, we concluded that UA induced HUVEC apoptosis and endothelial dysfunction by triggering oxidative and ER stress through PKC/eNOS-mediated eNOS activity and NO production. PMID:26935704

  20. A Scallop Nitric Oxide Synthase (NOS) with Structure Similar to Neuronal NOS and Its Involvement in the Immune Defense

    PubMed Central

    Jiang, Qiufen; Zhou, Zhi; Wang, Leilei; Wang, Lingling; Yue, Feng; Wang, Jingjing; Song, Linsheng

    2013-01-01

    Background Nitric oxide synthase (NOS) is responsible for synthesizing nitric oxide (NO) from L-arginine, and involved in multiple physiological functions. However, its immunological role in mollusc was seldom reported. Methodology In the present study, an NOS (CfNOS) gene was identified from the scallop Chlamys farreri encoding a polypeptide of 1486 amino acids. Its amino acid sequence shared 50.0~54.7, 40.7~47.0 and 42.5~44.5% similarities with vertebrate neuronal (n), endothelial (e) and inducible (i) NOSs, respectively. CfNOS contained PDZ, oxygenase and reductase domains, which resembled those in nNOS. The CfNOS mRNA transcripts expressed in all embryos and larvae after the 2-cell embryo stage, and were detectable in all tested tissues with the highest level in the gonad, and with the immune tissues hepatopancreas and haemocytes included. Moreover, the immunoreactive area of CfNOS distributed over the haemocyte cytoplasm and cell membrane. After LPS, β-glucan and PGN stimulation, the expression level of CfNOS mRNA in haemocytes increased significantly at 3 h (4.0-, 4.8- and 2.7-fold, respectively, P < 0.01), and reached the peak at 12 h (15.3- and 27.6-fold for LPS and β-glucan respectively, P < 0.01) and 24 h (17.3-fold for PGN, P < 0.01). In addition, TNF-α also induced the expression of CfNOS, which started to increase at 1 h (5.2-fold, P < 0.05) and peaked at 6 h (19.9-fold, P < 0.01). The catalytic activity of the native CfNOS protein was 30.3 ± 0.3 U mgprot-1, and it decreased significantly after the addition of the selective inhibitors of nNOS and iNOS (26.9 ± 0.4 and 29.3 ± 0.1 U mgprot-1, respectively, P < 0.01). Conclusions These results suggested that CfNOS, with identical structure with nNOS and similar enzymatic characteristics to nNOS and iNOS, played the immunological role of iNOS to be involved in the scallop immune defense against PAMPs and TNF-α. PMID:23922688

  1. 78 FR 28912 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

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    .... See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008) (SR... 23, 2009), 74 FR 56682 (November 2, 2009)(SR-NASDAQ-2009-091) (notice of filing and immediate effectiveness expanding and extending Penny Pilot); 60965 (November 9, 2009), 74 FR 59292 (November 17,...

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    ... NASDAQ OMX Group.\\3\\ \\3\\ See Securities Exchange Act Release Nos. 70269 (August 27, 2013), 78 FR 54336...), 78 FR 18378 (March 26, 2013) (SR-Phlx- 2013-28) (notice of filing and immediate effectiveness of... Securities Exchange Act Release No. 69041 (March 5, 2013), 78 FR 15791 (March 12, 2013)...

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    ...). \\12\\ See Securities Exchange Act Release Nos. 61483 (February 3, 2010), 75 FR 6753 (February 10, 2010..., 2010), 75 FR 40007 (July 13, 2010) (SR-BX-2010-045) (rule filings to enable the listing and trading of... Effectiveness of Proposed Rule Change Relating to Options on ETFS Gold Trust August 11, 2011. Pursuant...

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    ... Release No. 53128 (January 13, 2006), 71 FR 3550 (January 23, 2006) (File No. 10-131). The rule was amended in Securities Exchange Act Release Nos. 54155 (July 14, 2006), 71 FR 41291 (July 20, 2006) (SR-NASDAQ-2006-001); 60794 (October 6, 2009), 74 FR 52522 (October 13, 2009) (SR-NASDAQ-2009-084); and...

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    ... Securities Exchange Act Release Nos. 55153 (January 23, 2007), 72 FR 4553 (January 31, 2007)(SR-Phlx-2006-74)(notice of filing and approval order establishing Penny Pilot); 60873 (October 23, 2009), 74 FR 56675... Penny Pilot); 60966 (November 9, 2009), 74 FR 59331 (November 17, 2009)(SR-Phlx-2009- 94)(notice...

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    ... Exchange Act Release Nos. 55153 (January 23, 2007), 72 FR 4553 (January 31, 2007) (SR-Phlx-2006-74) (notice of filing and approval order establishing Penny Pilot); 60873 (October 23, 2009), 74 FR 56675... Penny Pilot); 60966 (November 9, 2009), 74 FR 59331 (November 17, 2009) (SR-Phlx-2009-94) (notice...

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    ... Market Volatility. \\3\\ See Securities Exchange Act Release No. 67565 (August 1, 2012), 77 FR 47144... (June 10, 2010), 75 FR 34186 (June 16, 2010) (File Nos. SR-BATS-2010-014; SR-EDGA-2010-01; SR-EDGX- 2010... Release No. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025). See also...

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    ... effectiveness adding seventy-five classes to Penny Pilot); 62029 (May 4, 2010), 75 FR 25895 (May 10, 2010) (SR... Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008) (SR-NASDAQ-2008-026) (notice of filing and immediate effectiveness establishing Penny Pilot); 60874 (October 23, 2009), 74...

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    ... seventy-five classes to Penny Pilot); 65969 (December 15, 2011), 76 FR 79268 (December 21, 2011) (SR... 31, 2013. See Securities Exchange Act Release Nos. 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008... (October 23, 2009), 74 FR 56682 (November 2, 2009) (SR-NASDAQ-2009-091) (notice of filing and...

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    ... extended through June 30, 2012. See Securities Exchange Act Release Nos. 55153 (January 23, 2007), 72 FR...); 60873 (October 23, 2009), 74 FR 56675 (November 2, 2009) (SR-Phlx-2009-91) (notice of filing and immediate effectiveness expanding and extending Penny Pilot); 60966 (November 9, 2009), 74 FR...