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1

Spina Bifida  

MedlinePLUS

... times, spina bifida occulta is not discovered until late childhood or adulthood. This type of spina bifida usually ... Spina bifida occulta might not be diagnosed until late childhood or adulthood, or might never be diagnosed. During ...

2

Spina Bifida  

MedlinePLUS

Spina bifida is a neural tube defect - a type of birth defect of the brain, spine, or spinal ... cord. Screening tests during pregnancy can check for spina bifida. Sometimes it is discovered only after the baby ...

3

Spina Bifida Occulta  

MedlinePLUS

Spina Bifida Occulta A mild form of Spina Bifida What is Spina Bifida Occulta? Spina Bifida Occulta (SBO) is a group of conditions affecting the ... out they have it through an X-ray. Spina Bifida Occulta usually doesn’t cause nervous system problems. Forms ...

4

Spina Bifida  

Microsoft Academic Search

Abnormal development of the spinal canal and cord is the most common cause of neurogenic bladder dysfunction in children.\\u000a Spina bifida, also known as myelodysplasia, is a general term that describes various abnormal conditions affecting spinal\\u000a cord function. Meningocele occurs when the meninges without neural elements extend beyond the vertebral canal. When the meninges\\u000a are accompanied by neural elements, a

Hiep T. Nguyen

5

Spina bifida (image)  

MedlinePLUS

Spina bifida is a congenital disorder (birth defect) in which the backbone and spinal canal do not close ... membranes protruding out of an affected infant's back. Spina bifida may also be nearly inconsequential, or may be ...

6

Parent Functioning in Families of Preadolescents With Spina Bifida: Longitudinal Implications for Child Adjustment  

Microsoft Academic Search

The purpose of this study was to test a strength-of-association model regarding possible longitudinal and bidirectional associations between parent functioning and child adjustment in families of children with spina bifida (n = 68) and families of able-bodied children (n = 68). Parent functioning was assessed across 3 domains: parenting stress, individual psychosocial adjustment, and marital satisfaction. Child adjustment was indexed

Deborah Friedman; Grayson N. Holmbeck; Barbara Jandasek; Jill Zukerman; Mona Abad

2004-01-01

7

Spina bifida grown up.  

PubMed

The majority of people with spina bifida in the United States are now older than 18 years of age. Health care delivery for adults with this condition should include routine surveillance for common conditions such as hypertension, hyperlipidemia and cancer. It should also address spina bifida-related complications such as pressure sores, lymphedema, sexual dysfunction and infertility, and hydrocephalus, as well as chiari-related symptoms such as sleep apnea and urologic and renal functioning. Almost all adults with spina bifida benefit from regular followup with specialists in urology, neurosurgery and physiatry. Health care providers for adults with spina bifida should recognize the impact of executive dysfunction and nonverbal learning disability on self management, independent living, and employment in adults with spina bifida. PMID:23572172

Liptak, Gregory S; Garver, Kimberlee; Dosa, Nienke P

2013-04-01

8

Living with Spina Bifida  

MedlinePLUS

... one of the following links: Newborns and Infants Toddlers and Preschoolers School-Aged Children Adolescents and Teenagers Young Adults Read Nancy's personal story about her son Clark who is living a full life with spina bifida. As a nurse, Nancy shares ...

9

Spina Bifida and Motherhood.  

ERIC Educational Resources Information Center

Two women with spina bifida, a disability in which the spinal cord and nerves are damaged, gave birth to healthy babies. The article points out the need to provide young girls having this condition with information and counseling regarding sexual relationships, parenthood, and child rearing. (CL)

Drakes, Olive

1984-01-01

10

Genetics and Spina Bifida  

MedlinePLUS

... Americans and more common in Hispanics than non-Hispanics.) Other things may raise the chance of having a baby with Spina Bifida, but they are not as well understood. These things include: Exposure to high temperatures in early pregnancy, such as prolonged high fevers Extended hot tub ...

11

Pathological Anatomy of Spina Bifida  

Microsoft Academic Search

Spina bifida occulta results from incomplete closure of the neural tube around the twentieth day of embryonic development\\u000a [1]. Spina bifida was described in the medieval literature and was recognized even earlier. Indeed, the association of foot\\u000a deformities with sacral hypertrichosis may be the origin of the mythological figure of the satyr [2]. The term spina bifida encompasses the entire

Aydin Sav

12

A Longitudinal Study of Pubertal Timing, Parent-Child Conflict, and Cohesion in Families of Young Adolescents With Spina Bifida  

Microsoft Academic Search

Objective: To study longitudinal associations between perceived pubertal timing and family conflict and co- hesion during the transition to adolescence in 68 families of children with spina bifida and 68 matched fami- lies with able-bodied children. Children were 8 or 9 years old at Time 1 and 10 or 11 years old at Time 2. Methods: Family conflict and cohesion

Rachael Millstein Coakley; Grayson N. Holmbeck; Deborah Friedman; Rachel Neff Greenley; Azure Welborn Thill

2002-01-01

13

The Child with Spina Bifida.  

ERIC Educational Resources Information Center

Intended for parents as well as professionals, the text provides information and practical suggestions on dealing with spina bifida and hydrocephalus. Part I (chapters 1 and 2) concentrates on the medical and physical aspects of the condition with discussions covering such areas as spina bifida's development, locomotor problems, and the role of…

Anderson, Elizabeth M.; Spain, Bernie

14

Genetics Home Reference: Spina bifida  

MedlinePLUS

... in the general population. Where can I find information about diagnosis or management of spina bifida? These resources address the diagnosis ... Urologic Care and Management You might also find information on the diagnosis or management of spina bifida in Educational resources and Patient ...

15

Longitudinal Study of Observed and Perceived Family Influences on Problem-Focused Coping Behaviors of Preadolescents With Spina Bifida  

Microsoft Academic Search

Objective: To study coping socialization longitudinally by examining reported and observed family environ- ment and parenting variables in relation to children's problem-focused coping in a sample of 68 families of preadolescents with spina bifida and 68 matched able-bodied comparison families. Methods: Family environment and parenting variables were assessed with mother and father reports and observational measures. Children's problem-focused coping was

Wendy L. McKernon; Grayson N. Holmbeck; Craig R. Colder; Jennifer S. Hommeyer; Wendy Shapera; Venette Westhoven

2001-01-01

16

Spina Bifida Data and Statistics  

MedlinePLUS

... Quality of Life [ Read summary ] Many adolescents and young adults with spina bifida report a high level of ... sports and other recreational activities. Some adolescents and young adults are concerned about their future because of secondary ...

17

Men's Health and Spina Bifida  

MedlinePLUS

... one's heallth care. Sexuality and Spina Bifida Helps adolescents, young adults and their caregivers discuss sexuality in an informative manner by providing information on the physical and social aspects of sexuality from a developmental ...

18

Women's Health and Spina Bifida  

MedlinePLUS

... one's heallth care. Sexuality and Spina Bifida Helps adolescents, young adults and their caregivers discuss sexuality in an informative manner by providing information on the physical and social aspects of sexuality from a developmental ...

19

Spina Bifida: Some Psychological Aspects  

ERIC Educational Resources Information Center

Examined were the intellectual ability, social adjustment, social competence, and personality characteristics of 33 children, 8-to 15-years-old with spina bifida (a malformation of the spinal cord). (CL)

Fulthorpe, Derek

1974-01-01

20

Integrating Pupils with Spina Bifida  

ERIC Educational Resources Information Center

A followup survey of parents and teachers of 155 children born with spina bifida, who were mildly handicapped and attended ordinary schools in London, indicated that there were no major problems with the children's placements. (IM)

Halliwell, Miles; Spain, Bernie

1977-01-01

21

Perinatal motor behaviour and neurological outcome in spina bifida aperta  

Microsoft Academic Search

Aim of the study: In the present longitudinal study we investigated the relationship between prenatal motor behaviour and the postnatal neurological sequelae of infants with spina bifida aperta. Methods and patients: Prenatal isolated leg movements and general movements of 13 fetuses\\/infants with spina bifida aperta were assessed by means of ultrasound recordings, and were compared with: 1. the spinal level

D. A. Sival; J. H. Begeer; A. L. Staal-Schreinemachers; J. M. E. Vos-Niël; J. R. Beekhuis; H. F. R. Prechtl

1997-01-01

22

Spina bifida (degrees of severity) (image)  

MedlinePLUS

Spina bifida is a congenital disorder (birth defect) in which the backbone and spinal canal do not close ... membranes protruding out of an affected infant's back. Spina bifida may also be nearly inconsequential, or may be ...

23

Medical Adherence in Young Adolescents with Spina Bifida: Longitudinal Associations with Family Functioning  

PubMed Central

Objective?The purpose of this study was 2-fold: (1) to explore the transfer of responsibility of medical tasks from parent to child during the transition to adolescence, and (2) to examine the associations between family functioning and medical adherence in youth with spina bifida.?Methods?Seventy families of children with spina bifida participated in this study. Data were collected during family interaction sessions by using questionnaires completed by mothers, fathers, youth, teachers and health professionals.?Results?Findings suggest that responsibility for medical regimens transfers gradually from parent to child over time. Additionally, family conflict and cohesion were correlated with medical adherence. Finally, family conflict over medical issues was related to a decrease in medical adherence over time.?Conclusions?Results suggest that as youth take more responsibility over their medical regimens, family conflict regarding medical issues becomes a contributor to their adherence behaviors. Interventions that target family conflict may facilitate adherence behaviors.

Stepansky, Mona A.; Roache, Caitlin R.; Schultz, Karen

2010-01-01

24

Spina Bifida. Fact Sheet = Espina Bifida. Hojas Informativas Sobre Discapacidades.  

ERIC Educational Resources Information Center

This fact sheet offers definitions of the three types of spina bifida (spina bifida occulta, meningocele, and myelomeningocele), outlines their incidence, describes characteristics of individuals with spina bifida, and reviews educational implications. The fact sheet discusses the need for many children with myelomeningocele to learn to manage…

National Information Center for Children and Youth with Disabilities, Washington, DC.

25

Spina bifida occulta in functional enuresis  

Microsoft Academic Search

Objective: To study incidence of spina bifida occulta in nocturnal enuresis cases and to compare outcome of enuresis with spina bifida\\u000a occulta and enuresis without spina bifida occulta.Methods: Patients with enuresis divided into two groups based on X-ray lumbosacral spine. Outcome of these patients were compared\\u000a on behavioral therapy.Results: Spina bifida occulta was detected in 18 out of total 48

Praveen Kumar; S. Aneja; Ramesh Kumar; Veena Taluja

2005-01-01

26

Mathematical Development in Spina Bifida  

ERIC Educational Resources Information Center

Spina bifida (SB) is a neural tube defect diagnosed before or at birth that is associated with a high incidence of math disability often without co-occurring difficulties in reading. SB provides an interesting population within which to examine the development of mathematical abilities and disability across the lifespan and in relation to the…

English, Lianne H.; Barnes, Marcia A.; Taylor, Heather B.; Landry, Susan H.

2009-01-01

27

Spina Bifida Association of America  

ERIC Educational Resources Information Center

The Statement of the Spina Bifida Association of America (SBAA) explains SB as a malformation of the central nervous system, reports the formation of SBAA in 1974, explains SBAA's emphasis on local chapter organization, and describes SBAA services, including a bimonthly publication, public education efforts, and research validation projects. (GW)

Exceptional Parent, 1974

1974-01-01

28

Orthopedic Management of Spina Bifida  

ERIC Educational Resources Information Center

|The management of orthopedic problems in spina bifida has seen a dramatic change over the past 10 years. The negative effects of spasticity, poor balance, and the tethered cord syndrome on ambulatory function are better appreciated. There is less emphasis on the hip radiograph and more emphasis on the function of the knee and the prevention of…

Thomson, Jeffrey D.; Segal, Lee S.

2010-01-01

29

Urologic Management of Spina Bifida  

ERIC Educational Resources Information Center

|The urologist plays an important role in the multidisciplinary team of physicians who provide care for patients with spina bifida. We review common strategies for managing the urinary tract in these patients. The primary objective in all phases of life is protecting kidney function by minimizing bladder hostility and establishing a good capacity,…

Clayton, Douglass B.; Brock, John W., III; Joseph, David B.

2010-01-01

30

Spina Bifida: Condition Information  

MedlinePLUS

... pronounced SPAHY-nuh BIF-i-duh ) is a neural tube defect that frequently occurs in families. Spina ... meninges) alone, called a meningocele, or with some neural elements, called a meningomyelocele. Or the defect may ...

31

Intellectual Outcome in Spina Bifida  

Microsoft Academic Search

In most of the series in the literature [1–4], the mean intelligence quotient (IQ) of patients with open spina bifida has\\u000a been reported to be within the normal range, but usually lower than that of the general population. In a recent case-control\\u000a study, [1] found a statistically significant correlation between having a myelomeningocele and having a lower IQ. However, this

Pietro Spennato; Luciano Savarese; Giuseppe Cinalli

32

Spina Bifida and Folic Acid Awareness  

ERIC Educational Resources Information Center

|Spina bifida is the most common, permanently disabling birth defect in the United States. It is a birth defect that involves incomplete formation of the spine during the first month of pregnancy--often before a woman even knows she is pregnant. Everyday, an average of eight babies are born with spina bifida or a similar birth defect of the brain…

Exceptional Parent, 2007

2007-01-01

33

Disability and quality of life in spina bifida and hydrocephalus  

Microsoft Academic Search

This study examined the impact of severity and type of condition and family resources on quality of life in children with spina bifida and hydrocephalus. A national UK sample of children aged between 6 and 13 years with spina bifida (n=62), hydrocephalus (n=354), and spina bifida plus hydrocephalus (n=128) were identified via the register of the Association for Spina Bifida

Ineke M Pit-ten Cate; Colin Kennedy; Jim Stevenson

2002-01-01

34

Trajectories of Psychosocial Adjustment in Adolescents with Spina Bifida: A 6-Year, Four-Wave Longitudinal Follow-up  

ERIC Educational Resources Information Center

Objective: As a follow-up to an earlier cross-sectional study (Holmbeck et al., 2003), the current multimethod, multi-informant investigation examined individual growth in psychosocial adjustment across the adolescent transition in 2 samples: young adolescents with spina bifida (SB) and typically developing adolescents (N = 68 in both groups at…

Holmbeck, Grayson N.; DeLucia, Christian; Essner, Bonnie; Kelly, Lauren; Zebracki, Kathy; Friedman, Deborah; Jandasek, Barbara

2010-01-01

35

Educational Placement of Children with Spina Bifida.  

ERIC Educational Resources Information Center

Procedures of school placement for 38 children (ages 5 to 18 years) with spina bifida in 23 school districts in western New York State were studied 5 years after a mandated process was enacted. (Author)

Lauder, Calvin E.; And Others

1979-01-01

36

Trajectories of Psychosocial Adjustment in Adolescents With Spina Bifida: A 6Year, Four-Wave Longitudinal Follow-Up  

Microsoft Academic Search

Objective: As a follow-up to an earlier cross-sectional study (Holmbeck et al., 2003), the current multimethod, multi-informant investigation examined individual growth in psychosocial adjustment across the adolescent transition in 2 samples: young adolescents with spina bifida (SB) and typically developing adolescents (N = 68 in both groups at Time 1). Method: Growth curve modeling procedures were used to describe the

Grayson N. Holmbeck; Christian DeLucia; Bonnie Essner; Lauren Kelly; Kathy Zebracki; Deborah Friedman; Barbara Jandasek

2010-01-01

37

Neocortical Reorganization in Spina Bifida  

PubMed Central

Normal brain development throughout childhood and adolescence is usually characterized by decreased cortical thickness in the frontal regions as well as region-specific patterns of increased white matter myelination and volume. We investigated total cerebral volumes, neocortical surface area, and neocortical thickness in 16 children with a neural tube defect, spina bifida myelomeningocele (SB), and 16 age-matched typically developing controls using a semi-automated, quantitative approach to MRI-based brain morphometry. The results revealed no significant group differences in total cerebral volume. However, group differences were observed in the global distribution of distinct tissue classes within the cerebrum: the SB group demonstrated a significant 15% reduction in total white matter and a 69% increase in cerebrospinal fluid, with no differences in total gray matter. Group comparisons of neocortical surface area assessments were significantly smaller in the occipital regions for SB, with no significant group differences in the frontal regions. Group comparisons of cortical thickness measurements demonstrated reduced cortical thickness in all regions except the frontal regions, where the SB group exhibited an increase relative to the PC group. Although regional patterns of thinning may be associated with the mechanical effects of hydrocephalus, the overall reduction in white matter and increased neocortical thickness in the frontal regions suggest that SB reflects a long term disruption of brain development that extends far beyond the neural tube defect in the first weeks of gestation.

Juranek, Jenifer; Fletcher, Jack M.; Hasan, Khader M.; Breier, Joshua I.; Cirino, Paul T.; Pazo-Alvarez, Paula; Diaz, Javier D.; Ewing-Cobbs, Linda; Dennis, Maureen; Papanicolaou, Andrew C.

2008-01-01

38

Urologic management of spina bifida.  

PubMed

The urologist plays an important role in the multidisciplinary team of physicians who provide care for patients with spina bifida. We review common strategies for managing the urinary tract in these patients. The primary objective in all phases of life is protecting kidney function by minimizing bladder hostility and establishing a good capacity, low-pressure urinary reservoir. Ensuring adequate bladder and bowel continence is also paramount for enhancing self-esteem and independence. Medical therapy incorporating clean intermittent catheterization and antimuscarinic medication is the cornerstone of neurogenic bladder management and often the only intervention required to achieve the above goals. Others may require formal lower urinary tract reconstruction to prevent urinary tract deterioration. As will be shown, current management, while effective, is not supported by strong evidence-based protocols; and the impact of any intervention upon quality of life, while subjectively seen as positive, does not have objective validation. These limitations are recognized and currently the subject of urologic investigation. PMID:20419776

Clayton, Douglass B; Brock, John W; Joseph, David B

2010-01-01

39

Traumatic sacral pseudomeningocele with spina bifida occulta.  

PubMed

Pseudomeningocele arises after spinal fracture and nerve root avulsion or after complications of spine surgery. However, traumatic pseudomeningocele with spina bifida occulta is rare. In this report, a traumatic pseudomeningocele in a patient with spina bifida occulta that required surgical treatment is documented. This 37-year-old man presented to the authors' hospital with headache and a fluctuant mass in the center of his buttocks. A CT scan with myelography and MR imaging of the sacral region revealed a large subcutaneous area of fluid retention communicating with the intradural space through a defect of the S-2 lamina. Because 3 months of conservative treatment was unsuccessful, a free fat graft was placed with fibrin glue to seal the closure of the defect, followed by 1 week of CSF drainage. This is the first report on traumatic pseudomeningocele with spina bifida occulta successfully treated in this manner. PMID:21943246

Banno, Tomohiro; Ohishi, Tsuyoshi; Suzuki, Daisuke; Honda, Yosuke; Kobayashi, Sho; Matsuyama, Yukihiro

2011-09-23

40

Spina bifida: a diagnostic dilemma in paleopathology.  

PubMed

This article provides information regarding the etiology, pathogenesis, and skeletal manifestation of spina bifida or spinal dysraphisms. On the basis of a review of the medical literature, it addresses discrepancies in documentation and interpretation of spina bifida in paleopathology. Furthermore, it offers suggestions for use of universal terminology and highlights the difficulties in the specific diagnosis of dysraphisms in skeletal remains. In addition, the necessity of examining the entire skeleton for abnormalities to distinguish simple delay/failure of fusion of the posterior neural arches from other occult spinal dysraphisms is emphasized, as it is the need for stratification of the sample by age and sex when reporting frequencies of sacral spina bifida occulta. PMID:20949487

Kumar, A; Tubbs, R Shane

2010-10-14

41

Spina Bifida and Anencephalus in Greater London  

Microsoft Academic Search

In order to make comparisons with the findings in a high frequency area, South Wales, with those in a low frequency area, south-east England, a birth frequency and family study was made of all births with neural tube malformations (spina bifida cystica, encephalocele, anencephaly, and iniencephaly) in 32 of the 33 London Boroughs over a 3-year period from 1 April

C. O. Carter; Kathleen Evans

1973-01-01

42

Treatment of hydromyelia in spina bifida  

Microsoft Academic Search

BACKGROUND Cavitation of the spinal cord (hydrosyringomyelia) seems to be common in spina bifida patients, although the overall clinical and radiological incidence has very rarely been analyzed. The real incidence of the condition is, in fact, difficult to assess as patients with this complication may remain relatively asymptomatic. The mechanisms accounting for the occurrence of hydrosyringomyelia in myelodysplasia are still

Massimo Caldarelli; Concezio Di Rocco; Frank La Marca

1998-01-01

43

Psychosocial and Family Functioning in Spina Bifida  

ERIC Educational Resources Information Center

A developmentally oriented bio-neuropsychosocial model is introduced to explain the variation in family functioning and psychosocial adjustment in youth and young adults with spina bifida (SB). Research on the family functioning and psychosocial adjustment of individuals with SB is reviewed. The findings of past research on families of youth with…

Holmbeck, Grayson N.; Devine, Katie A.

2010-01-01

44

Mathematics Performance of Children with Spina Bifida.  

ERIC Educational Resources Information Center

Mathematics performance in 32 children with spina bifida was investigated at 3.8 through 8.8 years and two years later. About half showed mathematics difficulties. At the time of the second data collection, 28% of the subjects were identified with mathematics and other learning disabilities and with language impairments. Visual perception…

French, Kathryn

1995-01-01

45

Selection for Treatment in Spina Bifida Cystica  

Microsoft Academic Search

This paper discusses (1) the mortality in 295 patients with myelomeningocele born 1961-9, (2) the “quality of life” of 88 surviving patients born 1961-5, and (3) their implications for selection for treatment in spina bifida cystica. Evidence is presented that high neurological levels, the presence of severe hydrocephalus, especially if present at birth, meningitis and ventriculitis, and gross renal disease

G. Keys Smith; E. Durham Smith

1973-01-01

46

The Cognitive Phenotype of Spina Bifida Meningomyelocele  

ERIC Educational Resources Information Center

A cognitive phenotype is a product of both assets and deficits that specifies what individuals with spina bifida meningomyelocele (SBM) can and cannot do and why they can or cannot do it. In this article, we review the cognitive phenotype of SBM and describe the processing assets and deficits that cut within and across content domains, sensory…

Dennis, Maureen; Barnes, Marcia A.

2010-01-01

47

Spina bifida and maternal Rh phenotype  

Microsoft Academic Search

Summary Based on the sample in this study (members of the Spina Bifida Association of America), there are approximately 2.15 times as many mothers with Rh-blood type than would be expected in a similar sized sample of the general population.

C. J. Sherry; D. Baker

1982-01-01

48

Tethered cord after spina bifida aperta: a longitudinal study of somatosensory evoked potentials  

Microsoft Academic Search

Progressive neurological deterioration may occur after meningomyelocele repair. Magnetic resonance imaging almost invariably demonstrates a conus medullaris in an abnormally low position, whether neurological symptoms develop or not. Surgery of a secondary tethered cord is indicated when progression of neurological symptoms is documented. We performed a longitudinal study of posterior tibial nerve somatosensory evoked potentials (SSEPs) in children and adolescents

R. Boor; M. Schwarz; B. Reitter; D. Voth

1993-01-01

49

Spina Bifida: General Information. Fact Sheet Number 12 = La Espina Bifida: Informacion General. Fact Sheet Number 21.  

ERIC Educational Resources Information Center

This fact sheet on spina bifida is offered in both English and Spanish. It provides definitions of the three types of spina bifida (spina bifida occulta, meningocele, and myelomeningocele). Incidence figures are given as are typical characteristics of children with spina bifida. Educational implications are briefly noted, including the need to…

Interstate Research Associates, McLean, VA.

50

Intrauterine treatment of spina bifida: primate model.  

PubMed

A spina-bifida-like condition was induced in 8 Macaca mulatta fetuses by intra-uterine lumbar laminectomy (L3-L5) followed by displacement of the spinal cord from the central canal. This condition was repaired in utero in 5 animals. A key feature of the repaired in utero in 5 animals. A key feature of the repair method was the use of allogeneic bone paste made from fetal bone particles suspended in an agar-thickened modified Dulbecco's medium. The bone paste was used to correct the bone deficit produced by the laminectomy. All of the monkey babies were delivered by cesarean section at near term (160-164 days of gestation). Neurological test on the neonates and subsequent morphological studies indicated that the in utero treated animals developed normally. In contrast, 3 control animals, which had the induced spinal dysraphism but were left untreated, showed severe spina-bifida-like abnormalities, including paraplegia, incontinence and somatosensory loss. PMID:6388186

Michejda, M

1984-08-01

51

Anesthesiology of the Newborn with Spina Bifida  

Microsoft Academic Search

Neural tube malformations involving the spinal cord and vertebral arches are referred to as spina bifida and present as a\\u000a spectrum of malformations with protrusion of the spinal cord and\\/or meninges through a defect in the vertebral arch at the\\u000a most severe end. Neural tube defects do not appear to be associated with other congenital syndromes; however, cardiac and\\u000a renal

Nigar Baykan

52

Cerebellar Motor Function in Spina Bifida Meningomyelocele  

Microsoft Academic Search

Spina bifida meningomyelocele (SBM), a congenital neurodevelopmental disorder, involves dysmorphology of the cerebellum, and\\u000a its most obvious manifestations are motor deficits. This paper reviews cerebellar neuropathology and motor function across\\u000a several motor systems well studied in SBM in relation to current models of cerebellar motor and timing function. Children\\u000a and adults with SBM have widespread motor deficits in trunk, upper

Maureen Dennis; Michael S. Salman; Jenifer Juranek; Jack M. Fletcher

2010-01-01

53

Spina Bifida Outcome: A 25Year Prospective  

Microsoft Academic Search

Background: Open spina bifida is the most complex congenital abnormality compatible with long-term survival. This report outlines the 20- to 25-year outcome for our original cohort of patients with a myelomeningocele treated in a nonselective, prospective manner. Methods: Of the initial 118 children, 71 patients were available for our most recent review. Nineteen patients have been lost to follow-up and

Robin M. Bowman; David G. McLone; John A. Grant; Tadanori Tomita; Joy A. Ito

2001-01-01

54

Spina bifida occulta: Radiographic and operative correlation  

Microsoft Academic Search

The clinical and myelographie evaluation in 24 children with spina bifida occulta has been correlated with the operative findings.\\u000a Myelograms were done using Myodil in 11 patients and Metrizamide in 13 patients. The diagnostic quality of myelograms done\\u000a with Metrizamide was comparatively better. Myodil myelography failed to demonstrate diastematomyelia in one case and a durai\\u000a sac in 3 cases of

M. Bajpai; V. Bhatnagar; D. K. Mitra; N. K. Mishra; M. Rohatgi; P. Upadhyaya

1989-01-01

55

The Cognitive Phenotype Of Spina Bifida Meningomyelocele  

PubMed Central

A cognitive phenotype is a product of both assets and deficits that specifies what individuals with spina bifida meningomyelocele (SBM) can and cannot do and why they can or cannot do it. In this paper, we review the cognitive phenotype of SBM and describe the processing assets and deficits that cut within and across content domains, sensory modality, and material, including studies from our laboratory and other investigations. We discuss some implications of the SBM cognitive phenotype for assessment, rehabilitation, and research.

Dennis, Maureen; Barnes, Marcia A.

2010-01-01

56

Adults with spina bifida and/or hydrocephalus.  

PubMed Central

Recent advances in medical technology enable many children with complex disabilities to survive into adulthood and to have certain expectations of life. One of these expectations is the continuity of specialist health care in an adult setting. This paper describes a new out-patient service which aims to provide optimum care, continuity and consistency of service for adults with spina bifida and/or hydrocephalus. The need for specialist health input into this service, in order to monitor the neurological, urological and psychosocial complications often associated with spina bifida and/or hydrocephalus is recognised. In one year (1992), 86 young adults with spina bifida and/or hydrocephalus attended for annual or more frequent assessment, either independently or with their families or carers. A variety of health and social problems were treated. In response to demand, a multi-disciplinary assessment unit, which includes the services of both medical and nursing specialists, occupational and physiotherapists, psychologists and access to specialist surgical opinions has recently opened at the Chelsea and Westminster Hospital. This new service attempts to meet some of the needs described in the outpatient audit. Adults with other disabilities are requesting to use this service. A longitudinal study to monitor quality, and outcome is indicated from this initial survey.

Morgan, D. J.; Blackburn, M.; Bax, M.

1995-01-01

57

Symposium on Spina Bifida (Denver, Colorado, November, 1969).  

ERIC Educational Resources Information Center

|The objectives of the symposium were to define the problems of the child with spina bifida and to present practical means of management, using a multi-disciplinary team approach. Eight papers defining the problem cover the epidemiology of spina bifida, pathophysiology, musculoskeletal defects, incontinence of bladder and bowel, problems of…

Colorado Univ., Denver. Medical Center.

58

Symposium on Spina Bifida (Denver, Colorado, November, 1969).  

ERIC Educational Resources Information Center

The objectives of the symposium were to define the problems of the child with spina bifida and to present practical means of management, using a multi-disciplinary team approach. Eight papers defining the problem cover the epidemiology of spina bifida, pathophysiology, musculoskeletal defects, incontinence of bladder and bowel, problems of…

Colorado Univ., Denver. Medical Center.

59

Psychological and Educational Studies with Spina Bifida Children. Final Report.  

ERIC Educational Resources Information Center

To measure school achievements in spina bifida children, to relate these measures to certain variables, to obtain information on educational problems, and to study facets of cognition and its changes with age, 77 spina bifida children and 53 amputees (all aged 5 to 15) were tested. Sixty non-disabled children were at times used for controls. The…

Diller, Leonard; And Others

60

Congenital vertebral anomalies: aetiology and relationship to spina bifida cystica  

Microsoft Academic Search

A family survey of 337 patients with congenital vertebral anomalies has been carried out from the Scoliosis Clinics of Edinburgh and the Royal National Orthopaedic Hospital, London. From genetic and epidemiological evidence it is clear that multiple vertebral anomalies (without apparent spina bifida) are aetiologically related to anencephaly and spina bifida cystics, carrying a 5-10% risk to subsequent sibs for

R Wynne-Davies

1975-01-01

61

Optimizing Health Care for Children with Spina Bifida  

ERIC Educational Resources Information Center

The health care needs of children with spina bifida are complex. They need specialists, generalists, and an integrated system to deliver this complex care and to align and inform all the providers. Most research in spina bifida has been focused on narrow medical outcomes; it has been noncollaborative, based on small samples of convenience, with no…

Liptak, Gregory S.; El Samra, Ahmad

2010-01-01

62

Optimizing Health Care for Children with Spina Bifida  

ERIC Educational Resources Information Center

|The health care needs of children with spina bifida are complex. They need specialists, generalists, and an integrated system to deliver this complex care and to align and inform all the providers. Most research in spina bifida has been focused on narrow medical outcomes; it has been noncollaborative, based on small samples of convenience, with…

Liptak, Gregory S.; El Samra, Ahmad

2010-01-01

63

Malformations of the spinal cord in 53 patients with spina bifida studied by magnetic resonance imaging  

Microsoft Academic Search

The incidence of associated malformations of the hindbrain and spinal cord in patients with spina bifida was investigated by a clinical and magnetic resonance study. The incidence of these malformations in combination with spina bifida was 49\\/53 (92.5%). Fiftytree children born with spina bifida aperta (40 patients) or spina bifida occulta (13 patients) formed the study group. The incidence of

Parvin C. Azimullah; Leo M. E. Smit; Elisabeth Rietveld-Knol; Jaap Valk

1991-01-01

64

A Longitudinal Assessment of Early Pubertal Timing as a Predictor of Psychosocial Changes in Adolescent Girls With and Without Spina Bifida  

PubMed Central

Objective?A longitudinal comparison of adolescent girls with and without spina bifida (SB), regarding the effects of early pubertal timing on girls’ depressive symptoms, mother–daughter conflict, and emotional distancing.?Methods?62 mother–daughter dyads (31 with SB and 31 without) reported on psychosocial outcomes at 5 time points (ages 8/9 to 16/17 years).?Results?A pubertal timing?×?SB status interaction predicted emotional distancing (T2), conflict (T2, T5), and depressive symptoms (T4), such that early maturing girls without SB reported the greatest increase in each outcome. Main effects of pubertal timing predicted emotional distancing (T4), conflict (T4), and depressive symptoms (T2, T3, T5). Findings were not always consistent across reporters, assessments of pubertal timing, and time-points.?Conclusions?Although early maturing girls in both groups may experience greater psychosocial difficulties, early maturing girls without SB may be most at-risk. The somewhat reduced impact of early pubertal timing in girls with SB is discussed.

Wasserman, Rachel M.; Lennon, Jaclyn M.; Amaro, Christina M.

2012-01-01

65

How Do Health Care Providers Diagnose Spina Bifida?  

MedlinePLUS

... examines blood in several ways to look for neural tube defects, such as spina bifida, and other ... 30/2012 Related A-Z Topics Birth Defects Neural Tube Defects (NTDs) NICHD News and Spotlights Division ...

66

Are There Disorders or Conditions Associated with Spina Bifida?  

MedlinePLUS

... movements. They also can develop urinary tract infections. Latex Allergy Many people with spina bifida—possibly three- ... of those with the condition—are allergic to latex, or natural rubber. While researchers still don’t ...

67

Screening for spina bifida cystica. A cost-benefit analysis.  

PubMed Central

The costs and economic benefits are examined of introducing a programme for the mass-screening of pregnancies for the detection and abortion of fetuses with spina bifida cystica. A benefit-cost index is derived, and the possible effects on it of making different input assumptions are discussed. It is considered that, on economic grounds, screening may be worthwhile only in populations in which the incidence of spina bifida is high.

Hagard, S; Carter, F; Milne, R G

1976-01-01

68

Complications with shunts in adults with spina bifida  

Microsoft Academic Search

AbstractObjective: To assess the incidence of malfunction of shunts in adults with spina bifida who have shunts to control hydrocephalus.Design: A retrospective review of the medical notes and contact by questionnaire of adults with spina bifida to assess symptoms, function of shunts, frequency of operative procedures, and follow up.Subjects: 110 patients with shunts who attended Lord Mayor Treloar College for

Pat Tomlinson; I D Sugarman

1995-01-01

69

Secondary impairments in young adults with spina bifida.  

PubMed

The aim of this study was to examine the prevalence of secondary impairments in young adults with spina bifida and to relate the prevalence to the type of spina bifida and the level of lesion. This cross-sectional study is part of the ASPINE (Adolescents with Spina Bifida in the Netherlands) study. Data were collected on medical history, hydrocephalus (shunt: yes/no), neurological level of lesion (International Standards for Neurological and Functional Classification of Spinal Cord Injury), visual acuity (Landolt rings), spasticity (Modified Ashworth Scale), contractures (range of motion), scoliosis (deviation from perpendicular), ambulation (Hoffer criteria), pressure sores and blood pressure (physical examination), epilepsy, pain, incontinence and sexuality (questionnaire), and cognitive functioning (Raven Standard Progressive Matrices). In total, 179 patients with spina bifida participated (41% male, age range 16 to 25 years, mean 20 years 9 months, SD 2 years 11 months). These were 37 patients with spina bifida occulta, 119 patients with spina bifida aperta and hydrocephalus (AHC+) and 23 patients with spina bifida aperta without hydrocephalus (AHC-). Of our patient group, 73 had a high-level lesion (L2 and above), 68 a mid-level lesion (L3 to L5), and 38 a low-level lesion (S1 and below). Both subdivisions were strongly related with patients with higher lesions more often having hydrocephalus. Most secondary impairments were found for patients with AHC+, and patients with AHC- were mostly comparable to patients with spina bifida occulta. According to level of lesion, most medical problems were found in the high-level lesion group. However, all subgroups suffered from health problems. PMID:15174535

Verhoef, M; Barf, H A; Post, M W M; van Asbeck, F W A; Gooskens, R H J M; Prevo, A J H

2004-06-01

70

Verb generation in children with spina bifida  

PubMed Central

We investigated verb generation in children with spina bifida meningomyelocele (SBM; n = 55) and in typically developing controls (n = 32). Participants completed 6 blocks (40 trials each) of a task requiring them to produce a semantically related verb in response to a target noun and an additional 40 trials on which they were simply required to read target nouns aloud. After controlling for reading response time, groups did not differ significantly in verb generation response time or learning. Children with SBM produced more non-verb errors than controls and tended to repeat their mistakes over blocks. Verb generation performance was associated with brain volume measures in participants with SBM. Congenital cerebellar dysmorphology is associated with impaired performance in verb generation accuracy, although not with increased response times to produce verbs.

DENNIS, MAUREEN; JEWELL, DERRYN; HETHERINGTON, ROSS; BURTON, CHRISTINE; BRANDT, MICHAEL E.; BLASER, SUSAN E.; FLETCHER, JACK M.

2008-01-01

71

Math and Numeracy in Young Adults With Spina Bifida and Hydrocephalus  

Microsoft Academic Search

The developmental stability of poor math skill was studied in 31 young adults with spina bifida and hydrocephalus (SBH), a neurodevelopmental disorder involving mal- formations of the brain and spinal cord. Longitudinally, individuals with poor math problem solving as children grew into adults with poor problem solving and limited functional numeracy. As a group, young adults with SBH had poor

Maureen Dennis; Marcia Barnes

2002-01-01

72

The Adolescent with Spina Bifida: Academic Achievement and Employment Prospects. Research Supplement.  

ERIC Educational Resources Information Center

A longitudinal study of 52 adolescents with spina bifida reveals information about their intelligence and attainments at age 16, achievement examinations, the relationship between IQ and academic achievement, and employment at 18 years. Among findings are significantly lower performance among Ss with shunts and intracranial complications. (CL)

Tew, Brian

1986-01-01

73

Bracing of Children with Paraplegia Resulting from Spina Bifida and Cerebral Palsy.  

National Technical Information Service (NTIS)

Two workshops (1969) on bracings of children with (1) paraplegia from spina bifida and (2) cerebral palsy reflected the current state of treatment programs for these patients. As far as the spina bifida patient with paraplegia was concerned, the consensus...

1970-01-01

74

Spina bifida and parental occupation: Results from three malformation monitoring programs in Europe  

Microsoft Academic Search

As the evidence for an association between spina bifida and parental agricultural occupations is inconclusive, we evaluated this association and the potential associations between spina bifida and other parental occupations. Three register-based case–referent studies were conducted in Sweden, Spain, and Hungary. From the registries of congenital malformations in each country, 482, 478, and 1119 cases with spina bifida were identified,

B. M. Blatter; N. Roeleveld; E. Bermejo; M. L. Martínez-Frías; C. Siffel; A. E. Czeizel

2000-01-01

75

Significance of spina bifida occulta in children with diurnal enuresis.  

PubMed

We reviewed retrospectively 456 patients with diurnal enuresis to determine the relationship between spina bifida occulta and attainment of continence. Of these patients 127 had undergone x-rays of the spine and 48 children (48%) had spina bifida occulta. The clinical course of these patients was compared to 79 enuretic children with normal spine films. All patients were initially treated with a timed voiding program and 28 with persistent enuresis were given anticholinergic medication. Findings on urodynamic studies were similar for both groups. Uninhibited bladder contractions were found in the majority of patients and 2 children in each group had hypertonic filling curves. Of 10 children with spina bifida occulta magnetic resonance imaging or ultrasound of the spine revealed lipoma and tethering of the cord in 1. Mean followup for both groups was 3 years. The outcome for enuretic children with spina bifida occulta was comparable to those with normal spine x-rays. The majority of patients had resolution of the enuresis with conservative management. Spinal ultrasound or magnetic resonance imaging may be warranted in those children with abnormal neurological findings on examination or hypertonic filling curves, or those who fail to respond to medical treatment. However, neurosurgical intervention to achieve continence appears necessary in only a small percentage of enuretic children with spina bifida occulta. PMID:8022022

Ritchey, M L; Sinha, A; DiPietro, M A; Huang, C; Flood, H; Bloom, D A

1994-08-01

76

Osteoporosis in paediatric patients with spina bifida  

PubMed Central

The prevalence and morbidity associated with osteoporosis and fractures in patients with spina bifida (SB) highlight the importance of osteoporosis prevention and treatment in early childhood; however, the issue has received little attention. The method for the selection of appropriate patients for drug treatment has not been clarified. Objective To review the literature concerning fracture risks and low bone density in paediatric patients with SB. We looked for studies describing state-of-the-art treatments and for prevention of secondary osteoporosis. Methods Articles were identified through a search in the electronic database (PUBMED) supplemented with reviews of the reference lists of selected papers. The main outcome measures were incidence of fractures and risk factors for fracture, an association between bone mineral density (BMD) and occurrence of fracture, risk factors of low BMD, and effects of pharmacological and non-pharmacological treatments on BMD and on the incidence of fractures. We considered as a secondary outcome the occurrence of fractures in relation to the mechanism of injury. Results Results indicated that patients with SB are at increased risk for fractures and low BMD. Risk factors that may predispose patients to fractures include higher levels of neurological involvement, non-ambulatory status, physical inactivity, hypercalciuria, higher body fat levels, contractures, and a previous spontaneous fracture. Limitations were observed in the number and quality of studies concerning osteoporosis prevention and treatment in paediatric patients with SB. The safety and efficiency of drugs to treat osteoporosis in adults have not been evaluated satisfactorily in children with SB.

Marreiros, Humberto Filipe; Loff, Clara; Calado, Eulalia

2012-01-01

77

Prospective memory in adults with spina bifida  

PubMed Central

Introduction Individuals with neurodevelopmental disorders have been observed to show accelerated cognitive aging or even dementia as early as 30 and 40 years of age. Memory deficits are an important component of age-related cognitive loss. Methods In this study, we investigated prospective memory, which is often impaired in aging, in a group of 32 adults with spina bifida meningomyelocele (SBM), including members of the oldest living cohort successfully treated with shunts to divert excess cerebrospinal fluid, ventriculomegaly, and hydrocephalus, who are now around 50 years of age. Seventeen typically developing adults provided a comparison group. Results The SBM and comparison groups differed in the prospective memory total score as well as in both time-based and event-based subscores. Prospective memory was impaired in both older and younger individuals with SBM. However, the percentage of individuals with impaired or poor prospective memory was three times higher in the older SBM group than in the younger SBM group. The results are considered in relation to specific features of the complex brain reorganization in SBM.

Dennis, Maureen; Nelson, Rebekah; Jewell, Derryn; Fletcher, Jack M.

2011-01-01

78

Cerebellar Motor Function in Spina Bifida Meningomyelocele  

PubMed Central

Spina bifida meningomyelocele (SBM), a congenital neurodevelopmental disorder, involves dysmorphology of the cerebellum, and its most obvious manifestations are motor deficits. This paper reviews cerebellar neuropathology and motor function across several motor systems well studied in SBM in relation to current models of cerebellar motor and timing function. Children and adults with SBM have widespread motor deficits in trunk, upper limbs, eyes, and speech articulators that are broadly congruent with those observed in adults with cerebellar lesions. The structure and function of the cerebellum are correlated with a range of motor functions. While motor learning is generally preserved in SBM, those motor functions requiring predictive signals and precise calibration of the temporal features of movement are impaired, resulting in deficits in smooth movement coordination as well as in the classical cerebellar triad of dysmetria, ataxia, and dysarthria. That motor function in individuals with SBM is disordered in a manner phenotypically similar to that in adult cerebellar lesions, and appears to involve similar deficits in predictive cerebellar motor control, suggests that age-based cerebellar motor plasticity is limited in individuals with this neurodevelopmental disorder.

Dennis, Maureen; Salman, Michael S.; Juranek, Jenifer; Fletcher, Jack M.

2010-01-01

79

38 CFR 21.8012 - Vocational training program for certain children of Vietnam veterans-spina bifida and covered...  

Code of Federal Regulations, 2010 CFR

...certain children of Vietnam veterans-spina bifida and covered birth defects. 21...Children of Vietnam Veterans-Spina Bifida and Covered Birth Defects General...children of Vietnam veteransâspina bifida and covered birth...

2010-07-01

80

38 CFR 21.8012 - Vocational training program for certain children of Vietnam veterans-spina bifida and covered...  

Code of Federal Regulations, 2010 CFR

...certain children of Vietnam veterans-spina bifida and covered birth defects. 21...Children of Vietnam Veterans-Spina Bifida and Covered Birth Defects General...children of Vietnam veteransâspina bifida and covered birth...

2009-07-01

81

[Current problems of the treatment of spina bifida aperta].  

PubMed

Experience in the treatment of 311 children with spina bifida aperta is generalized. The authors emphasize the hazard of infectious complications, which were the cause of death of 26.3% of children who were operated on 2 days after birth and before epithelization of the meningeal cavity. Internal hydrocephalus is congenital and linked etiopathogenetically with the Arnold-Chiari malformation. Treatment of internal hydrocephalus consists in ventriculoatrial and ventriculoperitoneal shunting. Spinal draining operations are not recommended. Postoperative mortality in spina bifida aperta has reduced to 3% in the recent years. PMID:3389012

Vetska, P; Tsekov, Kh; Undzhiian, S

82

Adult Consequences of Spina Bifida: A Cohort Study  

Microsoft Academic Search

Background  Patients with spina bifida potentially experience social isolation with limited employment opportunities and restriction of\\u000a independent living, neurologic and intellectual impairment, and orthopaedic and urologic consequences of their condition.\\u000a However, the degree of disability as these individuals age into adulthood has not been completely delineated.\\u000a \\u000a \\u000a \\u000a \\u000a Questions\\/purpose  In adults with spina bifida we determined the cause of death for those who had

James W. Roach; Barbara F. Short; Hanna M. Saltzman

2011-01-01

83

Reaching for Independence: Counseling Implications for Youth with Spina Bifida  

ERIC Educational Resources Information Center

Spina bifida, a congenital physical disability, is indirectly associated with difficulties in scholastic achievement, social development, and self-determination. Environment can have an impact on psychosocial development and impede functioning academically, socially, and vocationally. Counselors must be aware of the societal atmosphere to identify…

Brislin, Dawn C.

2008-01-01

84

38 CFR Care - Spina Bifida and Covered Birth Defects  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Spina Bifida and Covered Birth Defects Care Health Care Benefits for Certain Children of Vietnam Veterans Pensions...Pub. L. 102-54, 105 Stat. 271, 38 U.S.C. 501) Health Care Benefits for Certain Children of Vietnam...

2010-07-01

85

Physical Education for Students with Spina Bifida: Mothers' Perspectives  

ERIC Educational Resources Information Center

|This study described the meaning 7 mothers of children with spina bifida ascribed to their children's physical education, the mothers' roles in the schools, and the importance of the IEP in home and school communication. The stories of 4 mothers of elementary and 3 mothers of secondary aged children were gathered using the phenomenological…

An, Jihoun; Goodwin, Donna L.

2007-01-01

86

Evaluation of candidate genes for susceptibility to spina bifida  

Microsoft Academic Search

Neural tube defects (NTDs) are the most common severely disabling birth defects in the United States, with a frequency of approximately 1–2 of every 1,000 births. This text includes the identification and evaluation of candidate susceptibility genes that confer risk for the development of neural tube defects (NTDs). The project focused on isolated meningomyelocele, also termed spina bifida (SB). ^

Kelly Ann Volcik

2001-01-01

87

Quality of life in spina bifida: importance of parental hope  

Microsoft Academic Search

BACKGROUND AND AIMSPrognosis in spina bifida (SB) is often based only on neurological deficits present at birth. We hypothesised that both parental hope and the neurophysical examination predict quality of life in children and adolescents with SB.METHODSA previously validated disease and age specific health related quality of life (HRQL) instrument was posted to families of children (aged 5–12 years) and

Haresh M Kirpalani; Patricia C Parkin; Andrew R Willan; Darcy L Fehlings; Peter L Rosenbaum; D King; Alison J Van Nie

2000-01-01

88

Physical Education for Students with Spina Bifida: Mothers' Perspectives  

ERIC Educational Resources Information Center

This study described the meaning 7 mothers of children with spina bifida ascribed to their children's physical education, the mothers' roles in the schools, and the importance of the IEP in home and school communication. The stories of 4 mothers of elementary and 3 mothers of secondary aged children were gathered using the phenomenological methods…

An, Jihoun; Goodwin, Donna L.

2007-01-01

89

Physical Status and Psychosocial Adjustment in Children with Spina Bifida.  

ERIC Educational Resources Information Center

The study, in which mothers of 62 children with spina bifida completed the Child Behavior Checklist, found that children with differing degrees of physical problems and disability (determined from medical charts) did not differ significantly in their psychosocial adjustment. (Author/DB)

Wallander, Jan L.; And Others

1989-01-01

90

Spina bifida and anencephaly: miscarriage as possible cause  

Microsoft Academic Search

In two retrospective Liverpool surveys the domestic, family, dietary, and medical environments of the mothers of children affected by anencephaly or spina bifida, or both (ASB) were examined. None seemed to be of more than minor importance and the findings of others were therefore examined to see if they suggested a major factor. The most promising lead came from the

C Clarke; D Hobson; O M McKendrick; S C Rogers; P M Sheppard

1975-01-01

91

Children with Spina Bifida: Educational Implications of Their Medical Characteristics.  

ERIC Educational Resources Information Center

Many children with spina bifida present organic characteristics such as muscle weakness below the spinal lesion. These medical aspects are discussed with respect to their influence on teaching self-care and motor skills and reducing self-injurious behavior. Recommendations for educational programming are made. (Author/JDD)

Korabek, Cynthia A.; Cuvo, Anthony J.

1986-01-01

92

Continence in patients with spina bifida: long term results  

Microsoft Academic Search

One hundred and forty four questionnaires relating to bladder and bowel control were sent to a random selection of patients with spina bifida throughout the United Kingdom. One hundred and seventeen questionnaires were returned, of which 109 were usable. Twenty eight out of 109 responders had undergone some form of urinary diversion, of whom 20 (71%) were reliably dry. The

P S Malone; R A Wheeler; J E Williams

1994-01-01

93

Team Management of Cognitive Dysfunction in Children with Spina Bifida.  

ERIC Educational Resources Information Center

The article presents a summary of the cognitive difficulties often encountered when a multidisciplinary team attempts to manage children with spina bifida. Suggestions for intervention and program planning are presented. A model for team management incorporating medical, allied health, and psychosocial professionals is presented. (Author/CL)

Knowlton, Douglas D.; And Others

1985-01-01

94

Increasing Community Independence for Adolescents with Spina Bifida.  

ERIC Educational Resources Information Center

Examined whether a community-based habilitation program focusing on normalization and individual goal setting was effective in enhancing levels of independence in teenagers with spina bifida. Subjects (N=14) participated in an eight-week summer program. Results suggested the program was effective with the greatest strength being support and…

Sherman, Roberta G.; And Others

1985-01-01

95

Neonatal Loss of Motor Function in Human Spina Bifida Aperta  

Microsoft Academic Search

Objective. In neonates with spina bifida aperta (SBA), leg movements innervated by spinal seg- ments located caudal to the meningomyelocele are tran- siently present. This study in neonates with SBA aimed to determine whether the presence of leg movements indicates functional integrity of neuronal innervation and whether these leg movements disappear as a result of dysfunction of upper motor neurons

Deborah A. Sival; Tiemen W. van Weerden; Johan S. H. Vles; Albert Timmer; Wilfred F. A. den Dunnen; A. L. Staal-Schreinemachers; Eelco W. Hoving; Krystyne M. Sollie; Vivianne J. M. Kranen-Mastenbroek; Pieter J. J. Sauer; Oebele F. Brouwer

2010-01-01

96

Sensory tract abnormality in the chick model of spina bifida  

Microsoft Academic Search

Spina bifida aperta (SBA) is an open neural tube defect that occurs during the embryonic period. We created SBA chicks by incising the roof plate of the neural tube in the embryo. The area of the dorsal funiculus was smaller in the SBA chicks than in the normal controls. Additionally, the SBA group had fewer nerve fibres in the dorsal

Ryusuke Tsujimura; Katsumi Mominoki; Masae Kinutani; Tetsuya Shimokawa; Takuya Doihara; Hiroaki Nabeka; Hiroyuki Wakisaka; Naoto Kobayashi; Seiji Matsuda

97

Habilitation of Children and Young Adults with Spina Bifida  

Microsoft Academic Search

Spina bifida is a complex congenital condition that has far reaching complications and consequences for the affected child.\\u000a There are implications for mobility and self-care, independence, sensory function continence, schooling and social functioning,\\u000a and a range of medical complications that can also result in chronic illness [1–3].

Giuliana C. Antolovich; Alison C. Wray

98

38 CFR 3.814 - Monetary allowance under 38 U.S.C. chapter 18 for an individual suffering from spina bifida whose...  

Code of Federal Regulations, 2010 CFR

...for an individual suffering from spina bifida whose biological father or mother...for an individual suffering from spina bifida whose biological father or mother...is an individual suffering from spina bifida whose biological mother or...

2009-07-01

99

38 CFR 3.814 - Monetary allowance under 38 U.S.C. chapter 18 for an individual suffering from spina bifida whose...  

Code of Federal Regulations, 2010 CFR

...for an individual suffering from spina bifida whose biological father or mother...for an individual suffering from spina bifida whose biological father or mother...is an individual suffering from spina bifida whose biological mother or...

2010-07-01

100

Spina Bifida: General Information. Fact Sheet Number 12 = La Espina Bifida: Informacion General. Fact Sheet Number 12.  

ERIC Educational Resources Information Center

This fact sheet offers definitions of the three types of spina bifida, outlines their incidence, describes characteristics of individuals with spina bifida, and reviews educational implications. The fact sheet emphasizes that school programs should be flexible to accommodate these students' special needs and frequent absences, that children with…

National Information Center for Children and Youth with Disabilities, Washington, DC.

101

High prevalence of incontinence among young adults with spina bifida: description, prediction and problem perception  

Microsoft Academic Search

Study design:Cross-sectional study.Objectives:To study the prevalence of incontinence, problem perception and determinants of urinary and faecal incontinence in young adults with spina bifida.Setting:Nation-wide study in the Netherlands.Participants:A total of 179 of 350 invited patients participated, including 37 patients with spina bifida occulta and 142 with spina bifida aperta, of whom 119 had hydrocephalus; 41% were male and mean age was

M Verhoef; M Lurvink; H A Barf; M W M Post; F W A van Asbeck; R H J M Gooskens; A J H Prevo

2005-01-01

102

Mental rotation performance in children with hydrocephalus both with and without spina bifida.  

PubMed

The mental rotation ability in children with hydrocephalus and those with both hydrocephalus and spina bifida in comparison to healthy controls was investigated in this study. All groups performed a chronometric mental rotation test. Compared to children with hydrocephalus, children with both spina bifida and hydrocephalus showed an impaired mental rotation performance, demonstrated by slower reaction times. No significant performance difference was found between children with spina bifida and healthy controls. Error rates were comparable between groups indicating that the impaired mental rotation performance in children with both spina bifida and hydrocephalus is primarily due to motor impairment. PMID:24138214

Lehmann, Jennifer; Jansen, Petra

2013-10-01

103

Do Family Dynamics Mediate the Relationshp Between Early Pubertal Development and Depression for Girls With and Without Spina Bifida?  

Microsoft Academic Search

Girls who experience premature puberty have higher levels of depressive symptoms than their peers (Rierdan & Koff, 1991; Hayward et al., 1997). However, girls with spina bifida (SB) experience different psychosocial changes during puberty. This study proposed two longitudinal, mediated moderation models to investigate whether family variables (i.e., parent-child conflict and emotional distancing) contributed to differences in the connection between

Rachel Wasserman

2010-01-01

104

Spina Bifida: The Management of Extremity Deformities in Myelomeningocele  

Microsoft Academic Search

The spectrum of congenital neural tube defects, referred to as myelomeningocele (spina bifida), produces a wide variety of\\u000a disabilities, ranging from benign defects in the skin of the back to devastating paralysis and deformity of the lower extremities,\\u000a urinary and fecal incontinence, hydrocephalus, spasticity, and mental retardation. The care of children with myelomeningocele\\u000a usually requires a multidisciplinary approach. Early intervention

Bülent Erol; Junichi Tamai

105

Shifting genetic patterns in anencephaly and spina bifida  

Microsoft Academic Search

The long-term decline in the incidence of the neural tube malformations, anencephaly and spina bifida (ASB), ended in the mid-1950's in New York State. Since that time, the rate of these birth defects has remained between 1 and 1.5\\/1000 births. In this low incidence population, we tested the basic tenets which support a genetic aetiology. We found that the full

D T Janerich; J Piper

1978-01-01

106

Extradural spinal arachnoid cysts associated with spina bifida occulta  

Microsoft Academic Search

Summary  Introduction. Spinal extradural arachnoid cysts are an uncommon cause of neural compression in children. Even more uncommon is the association\\u000a of such cysts with spina bifida occulta.\\u000a \\u000a Material. Two girls, 12 and 8-years-old, presented with left leg pain, deteriorating gait, clinical signs of left L5 and S1 root compression,\\u000a without bladder or bowel symptoms. The first patient had left foot

K. Apel; S. Sgouros

2006-01-01

107

Treatment of the neurogenic bladder in spina bifida  

Microsoft Academic Search

Renal damage and renal failure are among the most severe complications of spina bifida. Over the past decades, a comprehensive\\u000a treatment strategy has been applied that results in minimal renal scaring. In addition, the majority of patients can be dry\\u000a for urine by the time they go to primary school. To obtain such results, it is mandatory to treat detrusor

Rafal Chrzan; Aart J. Klijn; Pieter Dik

2008-01-01

108

Assessment of health status in children with spina bifida  

Microsoft Academic Search

Study design:Prospective multidimensional study by means of: (1) clinical assessment, (2) parental-administered questionnaire for general health (CHQ-PF50), and (3) standardised disability measurements.Objectives:To assess the health-related quality of life (QoL) and disability in children with spina bifida (SB) and to correlate them with the clinical picture and our previous study on adolescents with SB.Setting:SB Centre at a University Hospital in Italy.Methods:A

C Rendeli; E Ausili; F Tabacco; P Caliandro; I Aprile; P Tonali; E Salvaggio; L Padua

2005-01-01

109

Quality of Life and Continence in Patients with Spina Bifida  

Microsoft Academic Search

Purpose:  Spina bifida (SB) is the most common congenital cause of incontinence in childhood. This study attempts to determine the relationships between urinary\\/faecal incontinence, methods of management, and Health Related Quality of Life (HRQoL) in people with SB.Patients and method:  A total of 460 patients (300 adults and 160 adolescents) from six centres in France have taken part in this cross-sectional study.

J. L. Lemelle; F. Guillemin; D. Aubert; J. M. Guys; H. Lottmann; S. Lortat-Jacob; P. Mouriquand; A. Ruffion; J. Moscovici; M. Schmitt

2006-01-01

110

Obesity among Persons with Spina Bifida  

MedlinePLUS

... Bifida Obesity is the most common nutritional problem in North America, and it is a serious health threat. How does obesity develop? All energy intake comes from food that is eaten (measured in calories) and then used by the body to ...

111

Seasonal variation in the frequency of anencephalus and spina bifida births in the United Kingdom.  

PubMed Central

There have been statistically significant seasonal variations of annencephalus and spina bifida in each country of the United Kingdom during 1964-79 with the exception of anencephalus births in Northern Ireland. The seasonal peaks, where discernible, are in phase. Embryos appear to develop anencephalus most commonly in May-June and spina bifida in July.

Maclean, M H; MacLeod, A

1984-01-01

112

Executive functioning and psychological adjustment in children and youth with spina bifida  

Microsoft Academic Search

Children and adolescents with spina bifida are at risk for poor neuropsychological functioning and psychological outcomes. The relationship between executive functioning and psychological adjustment is an area worthy of investigation in this population. The current study assessed executive functioning and psychological outcomes in a group of children and adolescents with spina bifida (SBM) (n?=?51) and nondisabled controls (n?=?45). A mediation

Natalie C. Kelly; Robert T. Ammerman; Joseph R. Rausch; M. Douglas Ris; Keith O. Yeates; Sonya G. Oppenheimer; Benedicta G. Enrile

2012-01-01

113

Executive functioning and psychological adjustment in children and youth with spina bifida  

Microsoft Academic Search

Children and adolescents with spina bifida are at risk for poor neuropsychological functioning and psychological outcomes. The relationship between executive functioning and psychological adjustment is an area worthy of investigation in this population. The current study assessed executive functioning and psychological outcomes in a group of children and adolescents with spina bifida (SBM) (n?=?51) and nondisabled controls (n?=?45). A mediation

Natalie C. Kelly; Robert T. Ammerman; Joseph R. Rausch; M. Douglas Ris; Keith O. Yeates; Sonya G. Oppenheimer; Benedicta G. Enrile

2011-01-01

114

Zur Pathogenese einer Endometriose im Bereich des Lumbalmarkes bei Spina bifida  

Microsoft Academic Search

Eine 39jährige Frau erkrankte vor 2 Jahren an einer Harninkontinenz mit Rückenschmerzen und neurologischen Störungen im Bereich der Bauchdecken und der unteren Extremitäten. Röntgenologisch wurde eine Spina bifida von L 4 bis S 1 festgestellt und eine Cyste in der Lumbalgegend vermutet. Die wegen der progredienten neurologischen Symptome indizierte Laminektomie bestätigte die Spina bifida und ergab zudem im Wirbelkanal eine

S. Sanfilippo; F. Niedobitek

1965-01-01

115

Leg dysfunctions in a hatched chick model of spina bifida aperta  

Microsoft Academic Search

We created chicks with spina bifida aperta (SBA) by incising the roof plate of the neural tube of embryos at Hamburger and Hamilton stage 18 or 19. Incision over the length of three somites caused spina bifida occulta (SBO)-like malformation in 47% of the hatchlings. Incision over the length of five and seven somites caused SBA-like malformation in 100% of

Katsumi Mominoki; Masae Kinutani; Hiroyuki Wakisaka; Shouichirou Saito; Naoto Kobayashi; Takashi Fujiwara; Seiji Matsuda

2006-01-01

116

Lumbar canal stenosis: a cause of late neurological deterioration in patients with spina bifida  

Microsoft Academic Search

BACKGROUNDPatients diagnosed with spina bifida may show late deterioration. This worsening in their clinical symptoms has been attributed to a multiplicity of causes such as secondary tethering of the spinal cord, Chiari II anomaly, hydromyelia, diastematomyelia, arachnoid cysts, and dermoid tumors.METHODSWe searched the clinical records of patients diagnosed with spina bifida who were treated at our hospital for a period

Juan F Martinez-Lage; Claudio Piqueras; Máximo Poza

2001-01-01

117

Psychiatric Symptomatology and Family Functioning in Children and Adolescents with Spina Bifida  

Microsoft Academic Search

The purpose of this study was to (a) examine the occurrence of psychiatric symptomatology in children and adolescents with spina bifida, (b) investigate the relationship between psychiatric features and aspects of disability, and (c) explore the impact of spina bifida and psychiatric status on family functioning. Fifty-four children and adolescents ages 6 to 18 years (M = 12.94, SD =

Robert T. Ammerman; Vincent R. Kane; Gregory T. Slomka; Donald H. Reigel; Michael D. Franzen; Kenneth D. Gadow

1998-01-01

118

Latex provocation tests in patients with spina bifida: Who is at risk of becoming symptomatic?  

Microsoft Academic Search

Background: Although there is accepted information on the prevalence rates of sensitization to latex in patients with spina bifida, little is known about the clinical relevance of this sensitization. Methods: We performed provocation tests with latex gloves in 159 patients with spina bifida (median age, 10 years). Results: Eighty-eight patients (55.3%) were sensitized to latex in terms of a positive

Bodo Niggemann; Dietke Buck; Theo Michael; Ulrich Wahn

1998-01-01

119

Changes in Medical Practice towards the Child with Spina Bifida: Implications for Schools.  

ERIC Educational Resources Information Center

The improved surgical management of children with spina bifida is among the reasons for a decreased number of severely physically and/or mentally affected children. Such improvements have resulted in more spina bifida children attending British ordinary schools and fewer attending special schools. (Author/DB)

Tew, Brian

1987-01-01

120

The Malone Antegrade Continence Enema Procedure in the Management of Patients with Spina Bifida  

Microsoft Academic Search

Background: In patients with spina bifida, traditional bowel management programs such as suppositories, retrograde enemas, and manual disimpaction have been largely unsatisfactory. The Malone antegrade continence enema (ACE) procedure has largely changed our approach to bowel management in this patient group.Study Design: Over a 3-year period between January 1994 and January 1997, 27 patients with spina bifida underwent the Malone

Terry W. Hensle; Elizabeth A. Reiley; David T. Chang

1998-01-01

121

Allergy to latex in spina bifida: A multivariate study of associated factors in 100 consecutive patients  

Microsoft Academic Search

BACKGROUND: Latex allergy is quite frequent in patients who have undergone multiple operations, such as children with spina bifida. OBJECTIVE: This investigation was carried to study the prevalence and risk factors associated with latex allergy in patients with spina bifida. METHODS: We studied 100 consecutive patients by skin prick tests and quantified specific IgE to latex with commercial antigens. RESULTS:

Antonio Nieto; Francisco Estornell; Angel Mazón; Carlos Reig; Alicia Nieto; Fernando García-Ibarra

1996-01-01

122

Factors that influence the presence of symptoms caused by latex allergy in children with spina bifida  

Microsoft Academic Search

Background: Some children with spina bifida who are sensitized to latex can have severe reactions, whereas others remain free of symptoms. Objective: Our aim was to study the differences between these two groups of patients. Material and methods: In 110 consecutive children with spina bifida, we identified by means of skin prick tests and serum latex-specific IgE 32 patients sensitized

Angel Mazón; Antonio Nieto; Francisco Estornell; Alicia Nieto; Carlos Reig; Fernando García-Ibarra

1997-01-01

123

Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation?  

Microsoft Academic Search

The aim of this study was to determine whether open lumbosacral spina bifida results from an abnormality of neural folding (primary neurulation) or medullary cord canalisation (secondary neurulation). Homozygous curly tail (ct) mouse embryos were studied as a model system for human neural tube defects. The rostral end of the spina bifida was found to lie at the level of

A J Copp; F A Brook

1989-01-01

124

Impairment of a Motor Skill in Children with Spina Bifida Cystica and Hydrocephalus: An Exploratory Study  

ERIC Educational Resources Information Center

Twenty 7-10 year old children with spina bifida cystica and hydrocephalus and 20 normals matched for age, sex and IQ were compared on a 12-trial target task, first used by Connolly, Brown & Bassett (1968). Findings are discussed in relation to neurological abnormalities in the spina bifida group. (Editor/RK)

Anderson, Elizabeth M.; Plewis, Ian

1977-01-01

125

Spina Bifida: Guidelines of Care for Children with Special Health Care Needs.  

ERIC Educational Resources Information Center

These guidelines were written to help families coordinate the health care that may be needed by a child with spina bifida. The booklet begins with general information about spina bifida. It then discusses the goals of health care, the health care team, the importance of periodic health care, and record keeping procedures. The child's health care…

Minnesota State Dept. of Health, Minneapolis. Services for Children with Handicaps.

126

Spina bifida: implications for cognitive functioning, disability and health in young adults  

Microsoft Academic Search

Spina bifida is a developmental birth defect involving the neural tube. It can result in a variety of problems, amongst them incontinence, restrictions of mobility and restrictions of cognitive functioning, depending on the severity of the defect. Due to improvements in medical care, the life expectancy of children with spina bifida has improved considerably and nowadays most children reach the

H. A. Barf

2008-01-01

127

IS SPINA BIFIDA OCCULTA ASSOCIATED WITH LOWER URINARY TRACT DYSFUNCTION IN CHILDREN?  

Microsoft Academic Search

Purpose:Of congenital malformations of the central nervous system 46% are abnormalities of the spinal cord, which includes spina bifida occulta. The occurrence and significance of spina bifida occulta in children with lower urinary tract and bowel dysfunction were evaluated prospectively.

M. SAMUEL; S. A. BODDY

2004-01-01

128

Neurological and medico-social problems of spina bifida patients in adolescence and adulthood  

Microsoft Academic Search

Chronological changes in the neurological manifestations of spina bifida are well recognized in the early developmental periods: fetal, neonatal, infantile, pre-school and school life. However, little has been written about the medical and medico-social problems of spina bifida patients in adulthood. Patients now in this age group had the condition diagnosed and managed in an era when modern neurosurgical concepts

Shizuo Oi; Osamu Sato; Satoshi Matsumoto

1996-01-01

129

Labor analgesia for pregnant women with spina bifida: What does an obstetrician need to know?  

Microsoft Academic Search

Neural tube defects, with a birth incidence of approximately 1\\/1,000, are the second most common (after congenital heart defects) type of congenital birth defects. The most common clinical presentations of neural tube defects include spina bifida and anencephaly. Spina bifida, which is one of the most common, serious malformations of human structure, is a general term that encompasses a wide

Krzysztof M. Kuczkowski

2007-01-01

130

COMPLICATIONS ASSOCIATED WITH CLEAN INTERMITTENT CATHETERIZATION IN CHILDREN WITH SPINA BIFIDA  

Microsoft Academic Search

Purpose: Clean intermittent catheterization (CIC) is commonly used in the management of voiding dysfunction associated with neurospinal dysraphism. We determined the incidence of genitourinary complications associated with this technique in a population of children with spina bifida. Materials and Methods: The charts of all children younger than 13 years attending a multi- disciplinary spina bifida clinic between 1987 and 2002

JEFFREY B. CAMPBELL; KATHERINE N. MOORE; DONALD C. VOAKLANDER; LAWRENCE W. MIX

2004-01-01

131

Fetal surgery for spina bifida: past, present, future.  

PubMed

Open spina bifida or myelomeningocele (MMC) is a common birth defect that is associated with significant lifelong morbidity. Little progress has been made in the postnatal surgical management of the child with spina bifida. Postnatal surgery is aimed at covering the exposed spinal cord, preventing infection, and treating hydrocephalus with a ventricular shunt. Experimental and clinical evidence suggest that the primary cause of the neurologic defects associated with MMC is not simply incomplete neurulation, but rather chronic, mechanical and amniotic-fluid induced chemical trauma that progressively damages the exposed neural tissue during gestation. The cerebrospinal fluid leak through the MMC leads to hindbrain herniation and hydrocephalus. In utero repair of open spina bifida is now performed in selected patients and presents an additional therapeutic alternative for expectant mothers carrying a fetus with MMC. In the past, studies in animal models and clinical case series laid the groundwork for a clinical trial to test the safety and efficacy of fetal MMC repair. In the present, a prospective, randomized study (the MOMS trial) has shown that fetal surgery for MMC before 26 weeks' gestation may preserve neurologic function, reverse the hindbrain herniation of the Chiari II malformation, and obviate the need for postnatal placement of a ventriculoperitoneal shunt. However, this study also demonstrates that fetal surgery is associated with significant risks related to the uterine scar and premature birth. In the future, research will expand our understanding of the pathophysiology of MMC, evaluate the long-term impact of in-utero intervention, and to refine timing and technique of fetal MMC surgery using tissue engineering technology. PMID:23395140

Adzick, N Scott

2013-02-01

132

Transcriptional Analyses of Two Mouse Models of Spina Bifida  

PubMed Central

Spina bifida is one of the most common of all human structural birth defects. Despite considerable effort over several decades, the causes and mechanisms underlying this malformation remain poorly characterized. In order to better understand the pathogenesis of this abnormality, we conducted a microarray study using Mouse Whole Genome Bioarrays which have ~36,000 gene targets, to compare gene expression profiles between two mouse models; CXL-Splotch and Fkbp8Gt(neo)which express a similar spina bifida phenotype. We anticipated that there would be a collection of overlapping genes or shared genetic pathways at the molecular level indicative of a common mechanism underlying the pathogenesis of spina bifida during embryonic development. A total of 54 genes were determined to be differentially expressed (25 down regulated, 29 upregulated) in the Fkbp8Gt(neo) mouse embryos; while 73 genes were differentially expressed (56 down regulated, 17 upregulated) in the CXL-Splotch mouse relative to their wildtype controls. Remarkably, the only two genes that showed decreased expression in both mutants were v-ski sarcoma viral oncogene homolog (Ski), and Zic1, a transcription factor member of the zinc finger family. Confirmation analysis using real time qRT-PCR indicated that only Zic1 was significantly decreased in both mutants. Gene Ontology analysis revealed striking enrichment of genes associated with mesoderm and central nervous system development in the CXL-Splotch mutant embryos, whereas in the Fkbp8Gt(neo) mutants, the genes involved in dorsal/ventral pattern formation, cell fate specification, and positive regulation of cell differentiation were most likely to be enriched. These results indicate that there are multiple pathways and gene networks perturbed in mouse embryos with shared phenotypes.

Cabrera, Robert M.; Finnell, Richard H.; Zhu, Huiping; Shaw, Gary M.; Wlodarczyk, Bogdan J.

2012-01-01

133

Contribution of the corticospinal tract to motor impairment in spina bifida.  

PubMed

We aimed to disentangle the proportional contributions of upper and lower motor neuron dysfunction to motor impairment in children with spina bifida. We enrolled 42 children (mean age, 11.2 years; standard deviation, 2.8 years) with spina bifida and 36 control children (mean age, 11.4 years; standard deviation, 2.6 years). Motor impairment was graded to severity scales in children with spina bifida. We recorded motor evoked potentials after transcranial and lumbosacral magnetic stimulation and compound muscle action potentials after electric nerve stimulation. Regarding lower motor neuron function, severely impaired children with spina bifida demonstrated smaller compound muscle action potential areas and lumbosacral motor evoked potential areas than control children; mildly impaired children hardly differed from control children. Compound muscle action potential latencies and lumbosacral motor evoked potential latencies did not differ between children with spina bifida and control children. Regarding upper motor neuron function, children with spina bifida demonstrated smaller transcranial motor evoked potential areas and longer central motor conduction times than control children. The smallest motor evoked potential areas and longest central motor conduction times were observed in severely impaired children. In children with spina bifida, the contribution of upper motor neuron dysfunction to motor impairment is more considerable than expected from clinical neurologic examination. PMID:22964441

Geerdink, Niels; Cuppen, Inge; Rotteveel, Jan; Mullaart, Reinier; Roeleveld, Nel; Pasman, Jaco

2012-10-01

134

Neuropsychological profile of young adults with spina bifida with or without hydrocephalus  

PubMed Central

Objectives: To determine the relative impact of hydrocephalus and spinal dysraphism in young adults on intellectual and cognitive functioning. Sub-groups of patients with congenital hydrocephalus and/or spina bifida were assessed between 1995 and 2003. The entry criteria were that individuals should have (i) intact global function, (ii) average verbal intelligence (or above), and (iii) should not have clinical depression. There were three sub-groups: patients with hydrocephalus and spina bifida, patients with hydrocephalus without spina bifida, and patients with spina bifida without hydrocephalus. Methods: Patients were neuropsychologically assessed as part of their normal clinical assessment during their annual medical review. Each individual completed a screening battery assessing global functioning, verbal intelligence, and mood. In addition they completed additional tests including measures of emotional intelligence, memory, attention, and executive function. Results were analysed to compare the performance of the patient sub-groups and to compare them to a healthy control group. Results: Patients with hydrocephalus (with or without spina bifida) were significantly impaired on the vast majority of all test scores as compared to patients with spina bifida and healthy controls. They were particularly poor on measures assessing executive function. By contrast for patients with spina bifida with no associated hydrocephalus, the significant majority of all test scores fell within the average range or above. Conclusions: The neuropsychological profile of patients with hydrocephalus is one of relative impairment and this is so whether or not spina bifida is present. In spina bifida alone, in the absence of hydrocephalus, cognitive function is relatively spared.

Iddon, J; Morgan, D; Loveday, C; Sahakian, B; Pickard, J

2004-01-01

135

Three-dimensional gait analysis in spina bifida.  

PubMed

This study was designed to determine gait patterns in children with lumbar and sacral neurologic level spina bifida. We studied a group of 28 children: 10 had L4-level lesions and a mean age of 11 years; eight had L5-level lesions and a mean age of 8 years; and 10 had S1-level lesions with a mean age of 12 years. A group of 15 normal children, mean age 10 years, was used for comparison. Each child underwent three-dimensional gait analysis using the Vicon system. We found that there were recognisable gait patterns for each level of spina bifida and that the abnormalities accurately reflected the muscle deficiencies present. The gait patterns approximated more closely to those of the normal group as the neurological level descended. The most important findings were of increased pelvic obliquity and rotation with hip abduction in stance (reflecting the gross Trendelenburg-type gait seen in these children) and persistent knee flexion throughout stance as a result of the absence of the plantar flexion-knee extension couple. We found that gait was not improved by tendon transfers performed either at the hip (posterolateral psoas transfer) or at the ankle (tibialis anterior transfer). PMID:8906653

Duffy, C M; Hill, A E; Cosgrove, A P; Corry, I S; Mollan, R A; Graham, H K

136

The Impact of Family, Peer, and School Contexts on Depressive Symptoms in Adolescents with Spina Bifida  

PubMed Central

Objective Based on social ecological theory, this study examined the joint relations among adolescents’ family, peer, and school contexts and depressive symptoms in youth with spina bifida using cumulative, protective, and specific effects models. Method Sixty families of adolescents with spina bifida and 65 comparison families reported on adolescent’s positive experiences within these contexts and on depressive symptoms when youth were 14–15 and 16–17 years old. Results Adolescents with spina bifida had fewer total positive contexts and less positive experience within peer and school contexts, as compared to typically developing adolescents. Greater total number of positive contexts and higher levels of positive experiences within family and school contexts were associated with fewer depressive symptoms for both groups; peer positive experiences were related to lower depressive symptoms for typically developing adolescents only. Conclusion Adolescents with spina bifida have fewer positive contexts, which may place them at risk for higher levels of depressive symptoms.

Essner, Bonnie S.; Holmbeck, Grayson N.

2010-01-01

137

Saving Money and Getting Help: Advice for Families of Children with Spina Bifida.  

ERIC Educational Resources Information Center

The excerpt from "Saving Money and Getting Help: Advice for Families of Children with Spina Bifida" (Lynn Rosenfeld) provides guidelines for parents concerning health insurance, health maintenance organizations, and questions to ask concerning health insurance coverage and filing claims. (DB)

Rosenfeld, Lynn; And Others

1987-01-01

138

Language Use without Comprehension: A Suggested Methodology for the Clinical Evaluation of Spina Bifida Children.  

ERIC Educational Resources Information Center

Three spina bifida children (mean age 66 months) were studied to illustrate the comprehension deficit and to demonstrate how evaluations can be structured. Available from Eterna Press, P.O. Box 19, Bolingbrook, Illinois 60439. (Author/PHR)

Culatta, Barbara

1978-01-01

139

The Infant and Young Child with Spina Bifida: Major Medical Concerns.  

ERIC Educational Resources Information Center

|This review of medical concerns in dealing with spina bifida examines neurologic and neurosurgical issues, learning issues, urological dysfunction, orthopedic issues, bowel control, latex allergy, and prenatal diagnosis and prevention. (JDD)|

Shaer, Catherine M.

1997-01-01

140

The Infant and Young Child with Spina Bifida: Major Medical Concerns.  

ERIC Educational Resources Information Center

This review of medical concerns in dealing with spina bifida examines neurologic and neurosurgical issues, learning issues, urological dysfunction, orthopedic issues, bowel control, latex allergy, and prenatal diagnosis and prevention. (JDD)

Shaer, Catherine M.

1997-01-01

141

A Camp-based Intervention Targeting Independence Among Individuals with Spina Bifida  

PubMed Central

Objective?To design and evaluate a camp-based intervention, the goal of which was to increase independence among children, adolescents, and adults with spina bifida.?Methods?An intervention targeting independence was embedded within a typical week long camp experience. The intervention consisted of the following: collaborative (i.e., parent and camper) goal identification, group sessions consisting of psycho-education and cognitive tools, and goal monitoring by camp counselors. Camper and parent report of demographic variables, goal attainment, spina bifida knowledge, and independence were gathered. Interventionist report of adherence to the treatment manual was also collected.?Results?Campers made significant gains in individual goals, management of spina bifida responsibilities, and independence with general spina bifida tasks, with medium effect sizes observed in goal attainment.?Conclusions?Results indicated that significant progress was made on individually oriented goals from pre- to post-camp. Design issues are discussed.

O'Mahar, Kerry; Jandasek, Barbara; Zukerman, Jill

2010-01-01

142

COMPLICATIONS ASSOCIATED WITH CLEAN INTERMITTENT CATHETERIZATION IN CHILDREN WITH SPINA BIFIDA  

Microsoft Academic Search

Purpose:Clean intermittent catheterization (CIC) is commonly used in the management of voiding dysfunction associated with neurospinal dysraphism. We determined the incidence of genitourinary complications associated with this technique in a population of children with spina bifida.

JEFFREY B. CAMPBELL; KATHERINE N. MOORE; DONALD C. VOAKLANDER; LAWRENCE W. MIX

2004-01-01

143

Prognosis of Spina Bifida in the Era of Prenatal Diagnosis and Termination of Pregnancy  

Microsoft Academic Search

Objective: To evaluate the current outcome of a selected prenatally diagnosed spina bifida group. Materials andMethods: We analyzed and followed up 74 cases of prenatally diagnosed spina bifida. Results: Termination of pregnancy was chosen in 72% of the cases and 28% were live-born. Chromosomal defects were identified in 16%, although only 1.6% in isolated cases. Of the 21 live births,

Susana Aguilera; Peter Soothill; Mark Denbow; Ian Pople

2009-01-01

144

The Natural History of Spina Bifida in Children Pilot Project: Research Protocol  

PubMed Central

Background Population-based empirical information to inform health care professionals working with children with spina bifida currently is lacking. Spina bifida is a highly complex condition that not only affects mobility but many additional aspects of life. We have developed a pilot project that focuses on a broad range of domains: surgeries, development and learning, nutrition and physical growth, mobility and functioning, general health, and family demographics. Specifically, we will: (1) explore the feasibility of identifying and recruiting participants using different recruitment sources, (2) test a multidisciplinary module to collect the data, (3) determine the utility of different methods of retrieving the data, and (4) summarize descriptive information on living with spina bifida. Objective The overall objective of the project was to provide information for a future multistate prospective study on the natural history of spina bifida. Methods Families with a child 3 to 6 years of age with a diagnosis of spina bifida were eligible for enrollment. Eligible families were identified through a US population-based tracking system for birth defects and from a local spina bifida clinic. Results This is an ongoing project with first results expected in 2013. Conclusions This project, and the planned multistate follow-up project, will provide information both to health care professionals experienced in providing care to patients with spina bifida, and to those who have yet to work with this population. The long-term purpose of this project is to increase the knowledge about growing up with spina bifida and to guide health care practices by prospectively studying a cohort of children born with this condition.

Thibadeau, Judy K

2013-01-01

145

Impact of Spina Bifida on Parental Caregivers: Findings from a Survey of Arkansas Families  

Microsoft Academic Search

The well-being of caregivers of children with spina bifida and other conditions is an important topic. We interviewed the\\u000a primary caregivers of 98 children aged 0–17 years with spina bifida sampled from a population-based birth defects registry\\u000a in Arkansas and the caregivers of 49 unaffected children. Measures of caregiver well-being were compared between the groups\\u000a and by level of lesion (sacral,

Scott D. Grosse; Alina L. Flores; Lijing Ouyang; James M. Robbins; John M. Tilford

2009-01-01

146

Malaysian Children with Spina Bifida: Relationship Between Functional Outcome and Level of Lesion  

Microsoft Academic Search

Purpose: To determine the relationship between spinal lesion level and functional outcome in children with spina bifida. Methods: Prospective observational study of 66 children who attended the Spina Bifida Clinic from 1994-1997. Data were obtained from serial physical examination and parent interview to determine mobility status, neurosensory deficits, continence and school placement. Results: Eighteen (27.3%) had high-level (thoracic and thoracolumbar),

L C Ong; Y N Lim; A Sofiah

147

The incidence of spina bifida occulta in a historic and a modern London population.  

PubMed Central

The incidence of spina bifida occulta was assessed in two London populations, one historic and the other contemporaneous. No significant differences were found between the two groups with regard to either overall frequency or frequency at specific sites within the lumbosacral column. This finding was compared to other studies reporting secular increases in the frequency of spina bifida occulta in areas outside the United Kingdom.

Saluja, P G

1988-01-01

148

Predictors of parenting stress in mothers of children with spina bifida  

Microsoft Academic Search

Study design:Prospective cross-sectional multidimensional study using clinical assessment and standard measures.Objectives:To determine the medical and social factors associated with parenting stress among mothers of children with spina bifida.Setting:Spina bifida clinics of two tertiary hospitals in urban Kuala Lumpur, Malaysia.Methods:A total of 81 mothers of children aged 1–18 years completed the Parenting Stress Index-Short Form (PSI\\/SF). Each child's adaptive skills were

Y Kanaheswari; N N A Razak; V Chandran; L C Ong

2011-01-01

149

Work participation among young adults with spina bifida in the Netherlands.  

PubMed

The aim of this study was to: (1) assess work participation among young adults with spina bifida, (2) identify problems perceived in finding employment, and (3) examine which determinants are related to work participation. This cross-sectional study was a follow-up study to the Adolescents with SPina bifida In the Netherlands (ASPINE) study. Data regarding work participation and problems finding employment were collected with questionnaire developed by the authors. Data on disease characteristics were taken from the ASPINE database. Responses of 136 participants were analyzed (77 females, 59 males; mean age 26 years 1 month [SD 3y1mo], range 21-32y). Twenty participants had spina bifida occulta and 116 had spina bifida aperta, 96 of whom also had hydrocephalus. Work participation rate was 62.5%, of which 22.4% was in a sheltered workplace. Significant determinants of having paid work for at least 1 hour a week were: level of education, level of lesion, hydrocephalus, IQ, functional independence, and ambulation. Significant determinants of full-time employment were the same, plus sex and type of spina bifida. In a multivariate backward logistic regression analysis, however, only level of education remained a significant predictor of work participation. Sex, level of education, and self-care independence were significant predictors of full-time employment. This study shows the importance of educational support and self-care independence training for children with spina bifida. PMID:18699861

van Mechelen, M C; Verhoef, M; van Asbeck, F W A; Post, M W M

2008-08-11

150

Early Information Processing among Infants with and without Spina Bifida  

PubMed Central

This study focuses on the development of early visual information processing among infants with Spina Bifida (SB) compared to typically developing infants using the habituation-dishabituation paradigm. Analyses were conducted in two stages. First infants were evaluated to determine if 18 month old infants (SB = 47; Control =40) differed in their ability to shift attention and habituate to two female faces, as well as their responses to composite and novel stimuli. Second, relations between these variables and infant motor and mental functioning were evaluated. The results of the study indicated that difficulties with visual attention skills can be detected as early as 18 months-of-age among infants with SB. Infants with SB differed significantly from controls on attention getting. Although there were no differences found on habituation and composite tasks, infants with SB differed significantly from controls on their ability to dishabituate. Implications are discussed.

Taylor, Heather B.; Landry, Susan H.; Barnes, Marcia; Swank, Paul; Cohen, Leslie B.; Fletcher, Jack

2010-01-01

151

Treatment of the neurogenic bladder in spina bifida.  

PubMed

Renal damage and renal failure are among the most severe complications of spina bifida. Over the past decades, a comprehensive treatment strategy has been applied that results in minimal renal scaring. In addition, the majority of patients can be dry for urine by the time they go to primary school. To obtain such results, it is mandatory to treat detrusor overactivity from birth onward, as upper urinary tract changes predominantly start in the first months of life. This means that new patients with spina bifida should be treated from birth by clean intermittent catheterization and pharmacological suppression of detrusor overactivity. Urinary tract infections, when present, need aggressive treatment, and in many patients, permanent prophylaxis is indicated. Later in life, therapy can be tailored to urodynamic findings. Children with paralyzed pelvic floor and hence urinary incontinence are routinely offered surgery around the age of 5 years to become dry. Rectus abdominis sling suspension of the bladder neck is the first-choice procedure, with good to excellent results in both male and female patients. In children with detrusor hyperactivity, detrusorectomy can be performed as an alternative for ileocystoplasty provided there is adequate bladder capacity. Wheelchair-bound patients can manage their bladder more easily with a continent catheterizable stoma on top of the bladder. This stoma provides them extra privacy and diminishes parental burden. Bowel management is done by retrograde or antegrade enema therapy. Concerning sexuality, special attention is needed to address expectations of adolescent patients. Sensibility of the glans penis can be restored by surgery in the majority of patients. PMID:18350321

de Jong, Tom P V M; Chrzan, Rafal; Klijn, Aart J; Dik, Pieter

2008-06-01

152

Reduction of latex sensitisation in spina bifida patients by a primary prophylaxis programme (five years experience).  

PubMed

Spina bifida patients represent a group with the highest risk for latex sensitisation and allergy with life-threatening symptoms mostly during surgery. At the end of 1995 we initiated a primary latex prophylaxis around and during surgery and anaesthesia of all spina bifida patients. The aim of our study was to investigate the prevalence of latex sensitisation in the spina bifida patients born during the five years after establishing latex prophylaxis in the Cologne Children's Hospital in December 1995. We investigated 34 serum samples of 27 spina bifida patients (mean age 2.4 years) for specific IgE antibodies against latex allergens (CAP system) and compared these patients born after 1995 with 38 spina bifida patients up to 5 years of age (mean 3.1 years) born before. In the prophylaxis group two of 27 patients (7 %), one of them with two operations outside the Children's Hospital, had low specific IgE against latex ( 100 kU/l (mean 22.6 kU/l, min 0.4 kU/l). Sera of 22 patients remained negative for latex IgE (min. 1, max. 19, mean 4.3 operations). By primary latex prophylaxis during surgery, anaesthesia and in paediatric wards the prevalence of latex sensitisation can be significantly reduced even in the high risk group of spina bifida patients. Problems can arise by the need for surgery in hospitals not experienced in the treatment of spina bifida patients, where latex prophylaxis is neglected. PMID:12541209

Cremer, R; Kleine-Diepenbruck, U; Hering, F; Holschneider, A M

2002-12-01

153

Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly  

PubMed Central

Abstract The impact of the posterior callosal anomalies associated with spina bifida on interhemispheric cortical connectivity is studied using a method for estimating cortical multivariable autoregressive models from scalp magnetoencephalography data. Interhemispheric effective and functional connectivity, measured using conditional Granger causality and coherence, respectively, is determined for the anterior and posterior cortical regions in a population of five spina bifida and five control subjects during a resting eyes-closed state. The estimated connectivity is shown to be consistent over the randomly selected subsets of the data for each subject. The posterior interhemispheric effective and functional connectivity and cortical power are significantly lower in the spina bifida group, a result that is consistent with posterior callosal anomalies. The anterior interhemispheric effective and functional connectivity are elevated in the spina bifida group, a result that may reflect compensatory mechanisms. In contrast, the intrahemispheric effective connectivity is comparable in the two groups. The differences between the spina bifida and control groups are most significant in the ? and ? bands.

Malekpour, Sheida; Li, Zhimin; Cheung, Bing Leung Patrick; Castillo, Eduardo M.; Papanicolaou, Andrew C.; Kramer, Larry A.; Fletcher, Jack M.

2012-01-01

154

Mutations in planar cell polarity gene SCRIB are associated with spina bifida.  

PubMed

Neural tube defects (NTDs) (OMIM #182940) including anencephaly, spina bifida and craniorachischisis, are severe congenital malformations that affect 0.5-1 in 1,000 live births in the United States, with varying prevalence around the world. Mutations in planar cell polarity (PCP) genes are believed to cause a variety of NTDs in both mice and humans. SCRIB is a PCP-associated gene. Mice that are homozygous for the Scrib p.I285K and circletail (Crc) mutations, present with the most severe form of NTDs, namely craniorachischisis. A recent study reported that mutations in SCRIB were associated with craniorachischisis in humans, but whether SCRIB mutations contribute to increased spina bifida risk is still unknown. We sequenced the SCRIB gene in 192 infants with spina bifida and 190 healthy controls. Among the spina bifida patients, we identified five novel missense mutations that were predicted-to-be-deleterious by the PolyPhen software. Of these five mutations, three of them (p.P1043L, p.P1332L, p.L1520R) significantly affected the subcellular localization of SCRIB. In addition, we demonstrated that the craniorachischisis mouse line-90 mutation I285K, also affected SCRIB subcellular localization. In contrast, only one novel missense mutation (p.A1257T) was detected in control samples, and it was predicted to be benign. This study demonstrated that rare deleterious mutations of SCRIB may contribute to the multifactorial risk for human spina bifida. PMID:23922697

Lei, Yunping; Zhu, Huiping; Duhon, Cody; Yang, Wei; Ross, M Elizabeth; Shaw, Gary M; Finnell, Richard H

2013-07-26

155

Interhemispheric effective and functional cortical connectivity signatures of spina bifida are consistent with callosal anomaly.  

PubMed

The impact of the posterior callosal anomalies associated with spina bifida on interhemispheric cortical connectivity is studied using a method for estimating cortical multivariable autoregressive models from scalp magnetoencephalography data. Interhemispheric effective and functional connectivity, measured using conditional Granger causality and coherence, respectively, is determined for the anterior and posterior cortical regions in a population of five spina bifida and five control subjects during a resting eyes-closed state. The estimated connectivity is shown to be consistent over the randomly selected subsets of the data for each subject. The posterior interhemispheric effective and functional connectivity and cortical power are significantly lower in the spina bifida group, a result that is consistent with posterior callosal anomalies. The anterior interhemispheric effective and functional connectivity are elevated in the spina bifida group, a result that may reflect compensatory mechanisms. In contrast, the intrahemispheric effective connectivity is comparable in the two groups. The differences between the spina bifida and control groups are most significant in the ? and ? bands. PMID:22571349

Malekpour, Sheida; Li, Zhimin; Cheung, Bing Leung Patrick; Castillo, Eduardo M; Papanicolaou, Andrew C; Kramer, Larry A; Fletcher, Jack M; Van Veen, Barry D

2012-06-28

156

Mutations in Planar Cell Polarity Gene SCRIB Are Associated with Spina Bifida  

PubMed Central

Neural tube defects (NTDs) (OMIM #182940) including anencephaly, spina bifida and craniorachischisis, are severe congenital malformations that affect 0.5–1 in 1,000 live births in the United States, with varying prevalence around the world. Mutations in planar cell polarity (PCP) genes are believed to cause a variety of NTDs in both mice and humans. SCRIB is a PCP-associated gene. Mice that are homozygous for the Scrib p.I285K and circletail (Crc) mutations, present with the most severe form of NTDs, namely craniorachischisis. A recent study reported that mutations in SCRIB were associated with craniorachischisis in humans, but whether SCRIB mutations contribute to increased spina bifida risk is still unknown. We sequenced the SCRIB gene in 192 infants with spina bifida and 190 healthy controls. Among the spina bifida patients, we identified five novel missense mutations that were predicted-to-be-deleterious by the PolyPhen software. Of these five mutations, three of them (p.P1043L, p.P1332L, p.L1520R) significantly affected the subcellular localization of SCRIB. In addition, we demonstrated that the craniorachischisis mouse line-90 mutation I285K, also affected SCRIB subcellular localization. In contrast, only one novel missense mutation (p.A1257T) was detected in control samples, and it was predicted to be benign. This study demonstrated that rare deleterious mutations of SCRIB may contribute to the multifactorial risk for human spina bifida.

Lei, Yunping; Zhu, Huiping; Duhon, Cody; Yang, Wei; Ross, M. Elizabeth; Shaw, Gary M.; Finnell, Richard H.

2013-01-01

157

Single-Stage Treatment of Spina Bifida with Hydrocephalus Based on a Prediction Rule Derived from Preoperative Cranial Ultrasound  

Microsoft Academic Search

Aims: It was the aim of this study to report a prospective study of 110 spina bifida patients with hydrocephalus treated by simultaneous ventriculoperitoneal (VP) shunt and repair of the meningomyelocele. Methods: Between January 2005 and February 2008, 264 patients with spina bifida were admitted to the author’s department. Those patients in whom the preoperative cranial ultrasonography measurement of the

Ashish Wakhlu; Geeta Wakhlu; Sunita Saxena; R. K. Tandon

2009-01-01

158

Experiences of Prenatal Diagnosis of Spina Bifida or Hydrocephalus in Parents Who Decide to Continue with Their Pregnancy  

Microsoft Academic Search

The current study aimed to gain an understanding of the perspectives of those parents provided with a prenatal diagnosis of spina bifida or hydrocephalus and who decided to continue with their pregnancy. Qualitative interviews were conducted with 15 parents who learned of their unborn child’s spina bifida and\\/or hydrocephalus in the prenatal period. The interviewer asked parents about their experiences

Julie Chaplin; Robert Schweitzer; Shelley Perkoulidis

2005-01-01

159

Continence in patients with spina bifida: long term results.  

PubMed Central

One hundred and forty four questionnaires relating to bladder and bowel control were sent to a random selection of patients with spina bifida throughout the United Kingdom. One hundred and seventeen questionnaires were returned, of which 109 were usable. Twenty eight out of 109 responders had undergone some form of urinary diversion, of whom 20 (71%) were reliably dry. The remaining 81 responders emptied their bladders by a variety of techniques including normal voiding, straining, expression, clean intermittent catheterisation, indwelling catheters, or they dribbled urine continuously. Only 31 (38%) of this group were reliably dry. Ninety four of 109 (86%) responders regularly sat on the toilet to evacuate their bowels and most used some aid such as manual evacuation, laxatives, suppositories, or enemas. Fifty five of 104 (53%) responders soiled regularly, 31 (56%) of whom were also wet. Forty seven per cent of dry patients (24/51) were faecally incontinent. Only 25 of 104 (24%) patients responding to all questions were reliably clean and dry.

Malone, P S; Wheeler, R A; Williams, J E

1994-01-01

160

Sensory tract abnormality in the chick model of spina bifida.  

PubMed

Spina bifida aperta (SBA) is an open neural tube defect that occurs during the embryonic period. We created SBA chicks by incising the roof plate of the neural tube in the embryo. The area of the dorsal funiculus was smaller in the SBA chicks than in the normal controls. Additionally, the SBA group had fewer nerve fibres in the dorsal funiculus than the normal controls. The pathway of the ascending sensory nerves was revealed by tracing the degenerated nerve fibres using osmification. We cut the sciatic nerve (L5) of the control and SBA chicks at the central end of the dorsal root ganglion 1 day after hatching and fixed the tissue 3 days later. Degenerated sensory nerve fibres were observed in the ipsilateral dorsal funiculus in the control chicks. In contrast, degenerated sensory nerve fibres were observed in the ipsilateral and contralateral dorsal, ventral and lateral funiculi of the spinal cord in the SBA chicks. Consequently, fewer sensory nerve fibres ascended to the thoracic dorsal funiculus in the SBA chicks than in the normal controls. This is the first report of abnormal changes in the ascending sensory nerve fibres in SBA. PMID:21658418

Tsujimura, Ryusuke; Mominoki, Katsumi; Kinutani, Masae; Shimokawa, Tetsuya; Doihara, Takuya; Nabeka, Hiroaki; Wakisaka, Hiroyuki; Kobayashi, Naoto; Matsuda, Seiji

2011-05-31

161

Proteomic analysis of amniotic fluid of pregnant rats with spina bifida aperta.  

PubMed

Congenital spina bifida aperta is a common congenital malformation in children and has an incidence of 1‰ to 5‰ in China. However, we currently lack specific biomarkers for screening or prenatal diagnosis and there is no method to entirely cure or prevent such defects. In this study, we used two-dimensional gel electrophoresis (2-DE)/mass spectrometry (MS) to characterize differentially expressed proteins in amniotic-fluid samples (AFSs) of embryonic day (E) 17.5 rat fetuses with spina bifida aperta induced by retinoic acid (RA). We identified five proteins differentially expressed in AFSs of spina bifida aperta, including three upregulated proteins (transferrin, alpha-1 antiproteinase and signal recognition particle receptor, B subunit [SRPRB] 55 kDa), two downregulated proteins (apolipoprotein A IV [APO A4] and Srprb 77 kDa). Specifically, we found 11 alpha-1 fetoprotein (AFP) fragments that were downregulated and 35 AFP fragments that were upregulated in AFSs from embryos with spina bifida aperta. Of the downregulated AFP fragments, 72.7% (8/11) were confined to the AFP N-terminus (amino acids [aas] 25-440) and 77.1% (27/35) of upregulated AFP fragments were confined to the AFP C-terminus (aas 340-596). We also confirmed APO A4 and AFP by immunoblot analysis. This is the first comparative proteomic study of AFSs from rat fetuses with spina bifida aperta. We demonstrate proteomic alterations in the AFS of spina bifida aperta, which may provide new insights in neural tube defects and contribute to the prenatal screening. PMID:22108047

Shan, Liping; Fan, Yang; Li, Hui; Liu, Wei; Gu, Hui; Zhou, Fenghua; Yuan, Zhengwei

2011-11-09

162

Calculus anuria in a spina bifida patient, who had solitary functioning kidney and recurrent renal calculi  

Microsoft Academic Search

Study design: Clinical case report with comments by colleagues from Austria, Belgium, Germany, Japan, and Poland.Objectives: To discuss challenges in the management of spinal bifida patients, who have marked kyphoscoliosis and no vascular access.Setting: Regional Spinal Injuries Centre, Southport, UK.Methods: A female patient, who was born with spina bifida, paraplegia and solitary right kidney, had undergone ileal loop urinary diversion.

S Vaidyanathan; B M Soni; J-J Wyndaele; A Z Buczynski; E Iwatsubo; M Stoehrer; H Madersbacher; R Peschel; G Singh; J W H Watt; P L Hughes; P Sett

2004-01-01

163

Évaluation de la fonction sexuelle des jeunes femmes ayant un spina-bifida avec une myéloméningocèle  

Microsoft Academic Search

Résumé\\u000a Objectifs  Évaluer la sexualité des jeunes femmes adultes ayant un spina-bifida avec une myéloméningocèle.\\u000a \\u000a \\u000a \\u000a Matériel et méthodes  Une étude transversale a été réalisée auprès de 44 femmes spina-bifida avec une myéloméningocèle âgées en moyenne de 27,66\\u000a ± 5,89 ans. Un autoquestionnaire a été envoyé par courrier postal. Il comprenait le bref index de la fonction sexuelle féminine\\u000a (BISF-W) et des questions

J. Moscovici; J. Guillotreau; J.-P. Sarramon; P. Rischmann; B. Malavaud

2011-01-01

164

Neurosurgical input at pre-natal counselling for parents of babies with Spina bifida.  

PubMed

Prenatal counselling can be helpful to parents in making a decision with regard to continuation of the pregnancy or to help prepare for the birth and the future life of a child with Spina bifida. We aimed to assess the effectiveness of our specialist neuro counselling sessions and to highlight areas that could be improved upon. This was in the form of a questionnaire given to parents, who had been through the counselling and continued with their pregnancy. The areas highlighted for improvement were more explicit information about urinary catheterisation, the need for admission to the special care baby unit (SCBU) and the need for an information leaflet on Spina bifida. PMID:23004013

Cockayne, Rebecca; Gibbon, Frances; Leach, Paul

2012-09-25

165

The longest faun tail forming dreadlocks with underlying spina bifida occulta.  

PubMed

Spina bifida is a developmental anomaly characterized by defective closure of the bony encasement of the spinal cord through which the spinal cord and meninges may or may not protrude. We report a rare case of a very long faun tail, which was in the form of a 20 inch long tail originating from the lumbosacral area in a rhomboidal pattern, measuring 10 x 8 inches. The case is being reported for its rare presentation of a 20 inch long faun tail with underlying spina bifida occulta. PMID:24021371

Brar, Balvinder Kaur; Mahajan, Bharat Bhushan; Mittal, Jyotisterna

2013-04-15

166

Hip and Spine Surgery is of Questionable Value in Spina Bifida: An Evidence-based Review  

Microsoft Academic Search

Background  Although many children with spina bifida and associated scoliosis or dislocated hips undergo spine or hip surgery, the benefits\\u000a are uncertain.\\u000a \\u000a \\u000a \\u000a \\u000a Questions\\/purposes  The purpose was to perform an evidence-based review on the benefits and risks of surgery for dislocated hips and scoliosis\\u000a in spina bifida.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  I performed a Medline® and Embase® search from 1950 to 2009 for Level I to Level

James G. Wright

2011-01-01

167

Prevalence of latex allergy in spina bifida patients in Singapore  

PubMed Central

Background Latex allergy and its clinical presentation are rising in prevalence across the globe, especially amongst patients with spina bifida (SB). While studies have been well-established in Europe and America, data from Asia are limited. Objective The aim of this study is to investigate the scenario in Singapore. Methods 35 subjects with SB, aged 5 to 32 years answered a questionnaire and underwent skin prick test (SPT) using a latex solution, 3 common house dust mites and 3 commonly cross-reacting food allergens (banana, kiwi and avocado). We also noted the relation between latex sensitization with atopy and doctor-diagnosed allergy. The prevalence of cross-reactivity with fruits was also studied. Results Sensitization to latex (i.e. a positive SPT) was found in 16 (46%, 95% confidence interval 29%-63%) of the subjects. Only 5 (31%) of the subjects who were sensitized to latex had clinical manifestations. Atopy (i.e. positive SPT to house dust mites) was present in 23 (66%) of the subjects and 13 (57%) of them was also sensitized to latex. There was a positive trend between latex sensitization and atopy (81.2% vs. 52.6%, p = 0.076), as well as latex sensitization with those having both atopy and doctor-diagnosed allergy (i.e. asthma, allergic rhinitis, eczema, drug allergy) (93.8% vs. 63.2%, p = 0.032). Only 6 (38%) subjects had allergy to the food allergens tested. Conclusion Almost half of the SB patients in Singapore are sensitized to latex. This number is comparable to that in Europe and America. Positive trend between latex sensitization and those with both atopy and doctor-diagnosed allergy (p = 0.032) is suggestive of a possible cause-effect relationship.

Chua, Xiuzhen; Mohamed, Javid

2013-01-01

168

Decreased activation and increased lateralization in brain functioning for selective attention and response inhibition in adolescents with spina bifida.  

PubMed

We used functional magnetic resonance imaging to evaluate functional activity in the brain of adolescents with spina bifida when performing selective attention and response inhibition tasks. We then compared the results to that of age-matched controls. Our results showed that adolescents with spina bifida had decreased frontal and superior parietal activation and more apparently low involvement of left brain hemisphere during these tasks. Our results indicated activation deficits and possibly abnormal functional organization in adolescents with spina bifida and associated pathologies such as hydrocephalus. PMID:22145814

Ou, Xiawei; Snow, Jeffrey H; Byerley, Amy K; Hall, John J; Glasier, Charles M

2011-12-06

169

Gender and morphogenetic variability of patients with spina bifida occulta and spina bifida aperta: prospective population-genetic study  

PubMed Central

Background: Aim of our study was to evaluate degree of genetic homozygosity in male and female gender of spina bifida (SB) occulta and SB aperta patients. Patients and Methods: We evaluated 95 patients with SB occulta and 51 with SB aperta. Degree of genetic homozygosity was evaluated by direct observation of 15 homozygously recessive characteristics (HRC) by HRC-test separately for SB occulta and SB aperta participants. Additionally 370 individuals without SB from Serbia were randomly selected and evaluated as control group. Male and female gender was separately evaluated for assessing degree of genetic homozygosity. Results: There was no significant difference in mean values of HRC between male and female gender in control group (male gender –3.9±1.2, female gender -4.0±1.4, z=0.39; p>0.05), SB occulta (male gender –4.1±1.5, female gender -4.7±1.4, z=1.87, p>0.05) and SB aperta patients (male gender –4.3±1.6, female gender -4.5±1.4, z=0.66, p>0.05), while there was significantly increased recessive homozygosity in female SB occulta group versus control female group (Females: SB occulta –4.7±1.4, Control group –4.0±1.4, z=3.16, p<0.01) and female SB aperta group versus control female group (Females: SB aperta –4.5±1.4, Control group –4.0±1.4, z=2.05, p<0.05). Conclusion: There is increased recessive homozygosity in tested female SB occulta and female SB aperta individuals versus SB male participants and significantly increased recessive homozygosity in female groups of SB patients versus control female group. These findings could lead to the possible assumption that different genes in different degree might be expressed in SB occulta and SB aperta patients.

Nikolic, D; Petronic, I; Cvjeticanin, S; Brdar, R; Cirovic, D; Bizic, M; Konstantinovic, L; Matanovic, D

2012-01-01

170

Gender and morphogenetic variability of patients with spina bifida occulta and spina bifida aperta: prospective population-genetic study.  

PubMed

Background: Aim of our study was to evaluate degree of genetic homozygosity in male and female gender of spina bifida (SB) occulta and SB aperta patients. Patients and Methods: We evaluated 95 patients with SB occulta and 51 with SB aperta. Degree of genetic homozygosity was evaluated by direct observation of 15 homozygously recessive characteristics (HRC) by HRC-test separately for SB occulta and SB aperta participants. Additionally 370 individuals without SB from Serbia were randomly selected and evaluated as control group. Male and female gender was separately evaluated for assessing degree of genetic homozygosity. Results: There was no significant difference in mean values of HRC between male and female gender in control group (male gender -3.9±1.2, female gender -4.0±1.4, z=0.39; p>0.05), SB occulta (male gender -4.1±1.5, female gender -4.7±1.4, z=1.87, p>0.05) and SB aperta patients (male gender -4.3±1.6, female gender -4.5±1.4, z=0.66, p>0.05), while there was significantly increased recessive homozygosity in female SB occulta group versus control female group (Females: SB occulta -4.7±1.4, Control group -4.0±1.4, z=3.16, p<0.01) and female SB aperta group versus control female group (Females: SB aperta -4.5±1.4, Control group -4.0±1.4, z=2.05, p<0.05). Conclusion: There is increased recessive homozygosity in tested female SB occulta and female SB aperta individuals versus SB male participants and significantly increased recessive homozygosity in female groups of SB patients versus control female group. These findings could lead to the possible assumption that different genes in different degree might be expressed in SB occulta and SB aperta patients. PMID:23930055

Nikolic, D; Petronic, I; Cvjeticanin, S; Brdar, R; Cirovic, D; Bizic, M; Konstantinovic, L; Matanovic, D

2012-01-01

171

Epidemiologic and Genetic Aspects of Spina Bifida and Other Neural Tube Defects  

ERIC Educational Resources Information Center

|The worldwide incidence of neural tube defects (NTDs) ranges from 1.0 to 10.0 per 1,000 births with almost equal frequencies between two major categories: anencephaly and spina bifida (SB). Epidemiological studies have provided valuable insight for (a) researchers to identify nongenetic and genetic factors contributing to etiology, (b) public…

Au, Kit Sing; Ashley-Koch, Allison; Northrup, Hope

2010-01-01

172

Trends in Spina Bifida and Anencephalus in the United States, 1991-2006  

MedlinePLUS

... Health E-Stats NCHS Health E-Stat Trends in Spina Bifida and Anencephalus in the United States, 1991-2006 by T.J. ... Page References Figures Tables PDF Version (78 KB) In 1992, the U.S. Public Health Service recommended that ...

173

Children with cerebral palsy, spina bifida and pragmatic language impairment: Differences and similarities in pragmatic ability  

Microsoft Academic Search

Pragmatically related abilities were studied in three clinical groups of children from 5 to 11 years of age; children with cerebral palsy (CP; n=10), children with spina bifida and hydrocephalus (SBH; n=10) and children with pragmatic language impairment (PLI; n=10), in order to explore pragmatic abilities within each group. A range of pragmatic, linguistic and cognitive assessments were performed, and

Pernille Holck; Ulrika Nettelbladt; Annika Dahlgren Sandberg

2009-01-01

174

Inferential ability in children with cerebral palsy, spina bifida and pragmatic language impairment  

Microsoft Academic Search

The aim of the study was to investigate and compare the ability to make inferences in three groups of children ranging from 5;2 to 10;9 years: 10 children with cerebral palsy (CP), 10 children with spina bifida and hydrocephalus (SBH) and 10 children with pragmatic language impairment (PLI). The relationship between inferential and literal comprehension was investigated by analysing atypical

Pernille Holck; Annika Dahlgren Sandberg; Ulrika Nettelbladt

2010-01-01

175

Inferential Ability in Children with Cerebral Palsy, Spina Bifida and Pragmatic Language Impairment  

ERIC Educational Resources Information Center

|The aim of the study was to investigate and compare the ability to make inferences in three groups of children ranging from 5;2 to 10;9 years: 10 children with cerebral palsy (CP), 10 children with spina bifida and hydrocephalus (SBH) and 10 children with pragmatic language impairment (PLI). The relationship between inferential and literal…

Holck, Pernille; Sandberg, Annika Dahlgren; Nettelbladt, Ulrika

2010-01-01

176

Changes in Medical Practice Towards the Child with Spina Bifida: Implications for Schools  

Microsoft Academic Search

Up to 15 years ago, Spina Bifida Cystica and its complications was the second most common physical handicap in childhood, but has declined in incidence, occurring about 5.9\\/10,000 births in the UK. Similar reductions have been noted in other parts of the world. Several different causes are responsible for the fewer numbers of children, but changes of surgical management known

Brian Tew

1987-01-01

177

Health Risk Behaviors in Spina Bifida: The Need for Clinical and Policy Action  

ERIC Educational Resources Information Center

|Health risk behaviors (HRBs) in adults with spina bifida such as poor diet, reduced physical activity, increased television viewing time, and substance abuse often have their genesis in early childhood. They are potentially preventable but if not addressed aggressively may continue to progress across the lifespan. Findings from a population-based…

Sawin, Kathleen J.; Brei, Timothy J.

2012-01-01

178

A model of neurocognitive function in spina bifida over the life span  

Microsoft Academic Search

Spina bifida myelomeningocele (SBM), a neural tube defect that is the product of a complex pattern of gene-environment interactions, is associated with naturally occurring, systematic variability in the neural phenotype and in environmental factors that lead to systematic variability in the cognitive phenotype. We characterize the basis for variability in the cognitive phenotype of children with SBM with reference to

MAUREEN DENNIS; SUSAN H. LANDRY; MARCIA BARNES; JACK M. FLETCHER

2006-01-01

179

Space-Based Inhibition of Return in Children With Spina Bifida  

Microsoft Academic Search

Inhibition of return (IOR) refers to an increase in time to react to a target in a previously attended location. Children with spina bifida meningomyelocele (SBM) and hydrocephalus have congenital dysmorphology of the midbrain, a brain region associated with the control of covert orienting in general and with IOR in particular. The authors studied exogenously cued covert orienting in 8-

Maureen Dennis; Kim Edelstein; Kim Copeland; Jon A. Frederick; David J. Francis; Ross Hetherington; Susan E. Blaser; Larry A. Kramer; James M. Drake; Michael E. Brandt; Jack M. Fletcher

2005-01-01

180

Bladder dysfunction and neurological disability at presentation in closed spina bifida  

Microsoft Academic Search

Congenital closed spinal anomalies are associated with distortion of the spinal cord, the spinal nerve roots or both, and can result in neurological abnormalities of the lower limbs and neuropathic bladder dysfunction. This study reports clinical and videourodynamic findings in a group of 51 patients with closed spina bifida. The mean age at presentation to a specialist neurourological clinic was

L B Johnston; M Borzyskowski

1998-01-01

181

A unifying hypothesis for hydrocephalus, Chiari malformation, syringomyelia, anencephaly and spina bifida  

Microsoft Academic Search

This work is a modified version of the Casey Holter Memorial prize essay presented to the Society for Research into Hydrocephalus and Spina Bifida, June 29th 2007, Heidelberg, Germany. It describes the origin and consequences of the Chiari malformation, and proposes that hydrocephalus is caused by inadequate central nervous system (CNS) venous drainage. A new hypothesis regarding the pathogenesis, anencephaly

Helen Williams

2008-01-01

182

Parents' psychological adjustment in families of children with Spina Bifida: a meta-analysis  

Microsoft Academic Search

BACKGROUND: Spina Bifida (SB) is the second most common birth defect worldwide. Since the chances of survival in children with severe SB-forms have increased, medical care has shifted its emphasis from life-saving interventions to fostering the quality of life for these children and their families. Little is known, however, about the impact of SB on family adjustment. Reviewers have struggled

Ignace PR Vermaes; Jan MAM Janssens; Anna MT Bosman; Jan RM Gerris

2005-01-01

183

Link between the CSF shunt and achievement in adults with spina bifida  

Microsoft Academic Search

OBJECTIVESA few enterprising adults with shunt treated spina bifida live independently in the community, have a job in competitive employment, and drive to work in their own car. By contrast others with similar disability but lacking their motivation remain dependent on care and supervision. The aim of this study was to identify events in the history of their shunt which

Gillian M Hunt; Pippa Oakeshott; Sally Kerry

1999-01-01

184

Inferential Ability in Children with Cerebral Palsy, Spina Bifida and Pragmatic Language Impairment  

ERIC Educational Resources Information Center

The aim of the study was to investigate and compare the ability to make inferences in three groups of children ranging from 5;2 to 10;9 years: 10 children with cerebral palsy (CP), 10 children with spina bifida and hydrocephalus (SBH) and 10 children with pragmatic language impairment (PLI). The relationship between inferential and literal…

Holck, Pernille; Sandberg, Annika Dahlgren; Nettelbladt, Ulrika

2010-01-01

185

The Arnold-Chiari Malformation and Its Implications for Individuals with Spina Bifida and Hydrocephalus.  

ERIC Educational Resources Information Center

The Arnold-Chiari malformation is present in most infants born with myelomeningocele (a form of spina bifida) and hydrocephalus. The syndrome is responsible for structural abnormalities in the brain, and peripheral nervous system. Etiology, symptoms, impact on central nervous system structures, surgical treatment, and implications for education…

Mittler, Joel E.

1986-01-01

186

The Effects of Cognitive Strategy Instruction on the Mathematical Problem Solving of Adolescents with Spina Bifida  

ERIC Educational Resources Information Center

This study investigated the effects of cognitive strategy instruction on the mathematical problem solving of three adolescents with spina bifida. Conditions of the multiple-baseline across-individuals design included baseline, two levels of treatment, posttesting, and maintenance. Treatment 1 focused on one-step math problems, and Treatment 2…

Coughlin, Judy; Montague, Marjorie

2011-01-01

187

The Management and Education of Children with Spina Bifida and Hydrocephalus.  

ERIC Educational Resources Information Center

The report describes the population of children in Australia with spina bifida and/or hydrocephalus, notes their needs and characteristics, reviews their school placement and social circumstances, and considers future educational services for them. Initial chapters review the literature on medical, psychoeducational, and social-family aspects of…

Andrews, Robert J.; Elkins, John

188

Treatment of Ventriculitis with Gentamicin and Cloxacillin in Infants Born with Spina Bifida  

Microsoft Academic Search

Of 783 newborn infants with spina bifida cystica and cranium bifidum treated in the 6 years to December 1966, 11% died of ventriculitis. 24% of all deaths were due to this cause. Experience with treatment of ventriculitis with 2 of the antibiotic drugs, gentamicin and cloxacillin, during an 18-month period is presented. CSF levels were estimated during systemic and intraventricular

J. Lorber; S. C. Kalhan; B. Mahgrefte

1970-01-01

189

Risk and Protective Influences in the Lives of Siblings of Youths with Spina Bifida  

ERIC Educational Resources Information Center

The impact of childhood chronic health conditions like spina bifida (SB) is a shared family experience. However, the lived experience of siblings is not well known. One hundred and fifty-five brothers and sisters of a child with SB responded to an open-ended question included in an anonymous self-administered mail questionnaire designed to enhance…

Bellin, Melissa H.; Kovacs, Pamela J.; Sawin, Kathleen J.

2008-01-01

190

Role of Early Parenting and Motor Skills on Development in Children with Spina Bifida  

ERIC Educational Resources Information Center

The impact of parenting and motor skills on the development of cognitive, language, and daily living skills was examined in 165 children (91 with spina bifida, SB), from 6-36 months of age. Motor scores significantly influenced cognitive, language, and daily living skills. Higher quality parenting was associated with higher levels of development…

Lomax-Bream, Laura E.; Taylor, Heather B.; Landry, Susan H.; Barnes, Marcia A.; Fletcher, Jack M.; Swank, Paul

2007-01-01

191

Educational Attainments of Spina Bifida Children Attending Ordinary or Special Schools.  

ERIC Educational Resources Information Center

Spina Bifida children (N=22) in regular and special schools were matched for IQ and their academic achievement compared. Data from tests revealed that Ss from special schools were behind their peers in mathematics with no significant differences in reading. (CL)

Carr, Janet; And Others

1983-01-01

192

Children with Cerebral Palsy, Spina Bifida and Pragmatic Language Impairment: Differences and Similarities in Pragmatic Ability  

ERIC Educational Resources Information Center

Pragmatically related abilities were studied in three clinical groups of children from 5 to 11 years of age; children with cerebral palsy (CP; n = 10), children with spina bifida and hydrocephalus (SBH; n = 10) and children with pragmatic language impairment (PLI; n = 10), in order to explore pragmatic abilities within each group. A range of…

Holck, Pernille; Nettelbladt, Ulrika; Sandberg, Annika Dahlgren

2009-01-01

193

Decline in the Prevalence of Spina Bifida and Anencephaly by Race\\/Ethnicity: 1995–2002  

Microsoft Academic Search

ABSTRACT. Objective. In an effort to reduce the oc- currence of neural tube defects (NTDs), folic acid forti- fication of US enriched grain products was authorized by the Food and Drug Administration in March 1996 and required by January 1998. Fortification has been shown to result in an important decline in the prevalence of spina bifida and anencephaly in the

Laura J. Williams; Mph Sonja A. Rasmussen; Alina Flores; Mph Russell S. Kirby; Larry D. Edmonds

194

The Language of Children with Spina Bifida and Hydrocephalus: Meeting Task Demands and Mastering Syntax.  

ERIC Educational Resources Information Center

Linguistic performance of 7 children (mean age=68 months) with spina bifida, hydrocephalus, and average intelligence was evaluated. Subjects dealt with the semantic-pragmatic requirements of linguistically posed problems in an age-appropriate manner. Performance declined as task demands increased but no more than performance of nondisabled…

Byrne, Karen; And Others

1990-01-01

195

Quality of Life in Individuals with Spina Bifida: A Research Update  

ERIC Educational Resources Information Center

Quality of life (QOL) is an important concept for individuals with chronic health conditions. Measuring and supporting QOL in children, adolescents, and adults with spina bifida (SB) may be especially unique given the broad range of complex health and rehabilitative challenges they encounter. This article provides a research update on (a)…

Sawin, Kathleen J.; Bellin, Melissa H.

2010-01-01

196

Arithmetic Processing in Children with Spina Bifida: Calculation Accuracy, Strategy Use, and Fact Retrieval Fluency  

ERIC Educational Resources Information Center

Three studies compared 98 children with spina bifida myelomeningocele (SBM)--a disorder associated with high rates of math disability and spatial deficits--to 94 typically developing children on multidigit subtraction and cognitive addition tasks. Children with SBM were classified into those with reading decoding and math disability, only math…

Barnes, Marcia A.; Wilkinson, Margaret; Khemani, Ekta; Boudesquie, Amy; Dennis, Maureen; Fletcher, Jack M.

2006-01-01

197

Spatial Knowledge of Children with Spina Bifida in a Virtual Large-Scale Space  

ERIC Educational Resources Information Center

The spatial knowledge of 18 children with spina bifida and 18 healthy control children (matched according to sex, age, and verbal IQ) was investigated in a computer-simulated environment. All children had to learn a route through a virtual floor system containing 18 landmarks. Controlling for cognitive abilities, the results revealed that children…

Wiedenbauer, Gunnar; Jansen-Osmann, Petra

2006-01-01

198

The effect of GABA receptor ligands in experimental spina bifida occulta  

Microsoft Academic Search

BACKGROUND: The pathophysiology behind spina bifida and other neural tube defects (NTDs) is unclear. Folic acid is one variable, but other factors remain. Studies suggest that substances active at the GABA receptor may produce NTDs. To test this hypothesis pregnant rats were exposed to either the GABA a agonist muscimol (1, 2 or 4 mg\\/kg), the GABA a antagonist bicuculline

Wayne Briner

2001-01-01

199

Die operative Behandlung der Spina bifida occulta bei direkten Fernsymptomen an den unteren Gliedmaßen  

Microsoft Academic Search

Zusammenfassung Bei der Spina bifida occulta finden sich außer primären Kombinationsmißbildungen und Schädigungen, die sich aus dem pathologisch-anatomischen Befund ableiten, sekundäre Fernwirkungen auf die unteren Gliedmaßen und die Blase. Während die primären Komplikationen sich aus dem Entwicklungsmangel des Rückenmarks erklären, wofür allein die Myelodysplasie als pathogenetischer Begriff gesetzt werden kann, beruhen die sekundären Fernsymptome auf der Beeinträchtigung nervaler Elemente im

K. F. Schlegel

1960-01-01

200

Transition to Adult Health Care for Adolescents with Spina Bifida: Research Issues  

ERIC Educational Resources Information Center

|The increasing survival of children and young people with congenital disabilities such as spina bifida (SB) provides a challenge to health care systems globally about how best to respond to the multitude of health, developmental, and psychosocial needs of those affected by this complex disorder across the lifespan, not just in childhood and…

Sawyer, Susan M.; Macnee, Sarah

2010-01-01

201

Association of folate metabolic pathway genes with human spina bifida meningomyelocele  

Microsoft Academic Search

Neural tube defects including spina bifida meningomyelocele (SBMM) are common malformations of the brain and spinal cord, and include all abnormalities resulting from lack of closure of the developing neural tube during embryological development.^ The specific aims of this study were to determine if single nucleotide polymorphic variants (SNPs) in the folate\\/homocysteine metabolic pathway genes confer a risk for NTD

Michelle R OByrne

2010-01-01

202

Acute abdominal symptoms and signs in children and young adults with spina bifida: Ten years' experience  

Microsoft Academic Search

Background\\/Purpose: Diagnosis and management of the acute abdomen in patients with spina bifida (SB) can be problematic. There are at least 4 clinical factors that can predispose to the development of acute abdominal symptoms and signs, and patients with a thoracic level lesion can have a partially insensate abdomen. The authors analyzed their accumulated experience to determine the annual incidence

Gordon Worley; John S Wiener; Timothy M George; Herbert E Fuchs; Joanne F Mackey; Robert D Fitch; Keith T Oldham

2001-01-01

203

Physical fitness, ambulation en physical activity in ambulatory children with spina bifida  

Microsoft Academic Search

Children with chronic disease or child-onset disability, like Spina Bifida (SB) are at increased risk of being inactive. Earlier studies in adolescents and young adults, have found correlations between an inactive lifestyle and lower levels of aerobic fitness. A second important issue being raised in this chapter is that of raised levels of energy cost of locomotion; with ambulation levels

J. F. de Groot

2010-01-01

204

The Influence of Juggling on Mental Rotation Performance in Children with Spina Bifida  

ERIC Educational Resources Information Center

|This study examined the influence of juggling training on mental rotation ability in children with spina bifida. Children between the ages of 8 and 12 solved a chronometric mental rotation test. Half of the children received juggling training (EG) over an 8 week time period; the other half did not receive training (CG). Afterwards, all…

Lehmann, Jennifer; Jansen, Petra

2012-01-01

205

Children with Cerebral Palsy, Spina Bifida and Pragmatic Language Impairment: Differences and Similarities in Pragmatic Ability  

ERIC Educational Resources Information Center

|Pragmatically related abilities were studied in three clinical groups of children from 5 to 11 years of age; children with cerebral palsy (CP; n = 10), children with spina bifida and hydrocephalus (SBH; n = 10) and children with pragmatic language impairment (PLI; n = 10), in order to explore pragmatic abilities within each group. A range of…

Holck, Pernille; Nettelbladt, Ulrika; Sandberg, Annika Dahlgren

2009-01-01

206

Unilateral spondylolysis associated with spina bifida occulta and nerve root compression.  

PubMed

Three patients with unilateral spondylolysis and spina bifida occulta were treated with hemilaminectomy, pseudarthrosis excision, and bilateral posterolateral fusion. All patients had persistent radiating leg pain, a positive sciatic tension sign, an objective neurologic deficit, and neuroradiographic studies that confirmed isolated L5 nerve root entrapment at the pars defect. Postoperatively, all patients noted complete relief of their radicular symptoms. PMID:2205929

Burkus, J K

1990-06-01

207

Cognitive functioning in patients with spina bifida, hydrocephalus, and the “cocktail party” syndrome  

Microsoft Academic Search

The cocktail party syndrome is a disorder seen in some patients with a history of hydrocephalus and it is particularly prevalent among patients with spina bifida. Patients with the disorder are verbose with good articulation, but are noted to have shallow intellect, poor social skills, poor academic skills, and poor daily living skills. Previous research has reported a close association

Anne DesNoyers Hurley; Casey Dorman; Linda Laatsch; Sheila Bell; Janice DAvignon

1990-01-01

208

Home screening for bacteriuria in children with spina bifida and clean intermittent catheterization  

PubMed Central

Background Significant bacteriuria (SBU) and urinary tract infections (UTIs) are common in patients with spina bifida and neuropathic detrusor sphincter dysfunction. Laboratory agar plated culture is the gold standard to establish SBU. It has the disadvantage of diagnostic and subsequent therapeutic delay. Leukocyte esterase tests (LETs) and dip slides proved to be useful in the general populations to exclude SBU and UTI. The aim of this study was to evaluate the reliability of LET and dip slide in children with spina bifida without symptoms of UTI. The reliability in children with asymptomatic SBU was not studied before. Methods In one hundred and twelve children with spina bifida on clean intermittent catheterization LETs and dip slides were compared with laboratory cultures. Both tests and agar plated cultures were performed on catheterized urine samples. The hypothesis was that the home tests are as accurate as laboratory cultures. Results A SBU was found in 45 (40%) of the 112 laboratory cultures. A negative LET excluded SBU (negative predictive value 96%), while a positive LET had a positive predictive value of 72%. The false positive rate was 28%. Dip slide determination of bacterial growth had no added value, other than serving as transport medium. Conclusions In spina bifida children, leukocyte esterase testing can be used to exclude significant bacteriuria at home, while dip slide tests have no added value to diagnose or exclude significant bacteriuria.

2012-01-01

209

Quantitative analysis of motor neurons of the levator ani muscle in fetal rats with spina bifida occulta  

Microsoft Academic Search

BackgroundWith the combination of microsurgery and microinjection techniques, we investigated the development of motor neurons in the spinal cord of fetal rats with spina bifida occulta by injecting the retrograde trace FG into the levator ani muscle.

Yong Li; Xiang-Yu Hou; Zheng-Wei Yuan; Wei-Lin Wang

2009-01-01

210

Survival and mobility in open spina bifida: Comparison of results from the United States and the United Kingdom  

Microsoft Academic Search

The prognosis for survival in spina bifida is an important issue for life-care planners and care-givers. This study documents and compares long-term survival in open spina bifida in California, United States of America, and Cambridge, United Kingdom and investigates the relation between mobility in childhood and long-term survival. Survival after the age 6 years was similar in the two series,

Pippa Oakeshott; Gillian M Hunt; Sally Kerry; David J. Strauss; Robert M. Shavelle; Robert J. Reynolds

211

Natural rubber latex allergy: prevalence and risk factors in patients with spina bifida compared with atopic children and controls  

Microsoft Academic Search

Type 1 allergy against natural rubber latex is an increasing problem in health care workers and children with spina bifida\\u000a or urogenital malformations. The aim of our study was to evaluate the prevalence of latex IgE antibodies and cross-reacting\\u000a fruit antibodies in patients with spina bifida compared with atopic and non-atopic controls. Risk factors for sensitization\\u000a should be determined. Sera

R. Cremer; A. Hoppe; E. Korsch; U. Kleine-Diepenbruck; F. Bläker

1997-01-01

212

Maternal periconceptional factors affect the risk of spina bifida-affected pregnancies: an Italian case–control study  

Microsoft Academic Search

Purpose  Neural tube defects, including spina bifida and anencephaly, are the second most common birth defects with an incidence in\\u000a Italy of 0.4–1\\/1,000. Information on factors playing a role in the pathogenesis of spina bifida is based on populations with\\u000a different exposures, lifestyle, social and cultural habits compared to Italian people. Our objective was to fill this gap\\u000a by using data

Patrizia De Marco; Elisa Merello; Maria Grazia Calevo; Samantha Mascelli; Daniela Pastorino; Lucia Crocetti; Pierangela De Biasio; Gianluca Piatelli; Armando Cama; Valeria Capra

2011-01-01

213

An x-ray study of valgus ankles in spina bifida children with valgus flat foot deformity.  

PubMed

Radiological examination of the ankles of spina bifida children with flail lower limbs and valgus flat foot deformity has revealed a high incidence of abnormal valgus tilt of the ankle-joint. A study of ankle X-rays of spina bifida children before and after extra-articular subtalar fusion in which the bone graft is removed from the ipsilateral tibia has shown that the valgus tilt of the mortice may increase after this procedure. PMID:1105595

Hollingsworth, R P

1975-08-01

214

Disruption of PDGFR?-initiated PI3K activation and migration of somite derivatives leads to spina bifida  

PubMed Central

Spina bifida, or failure of the vertebrae to close at the midline, is a common congenital malformation in humans that is often synonymous with neural tube defects (NTDs). However, it is likely that other etiologies exist. Genetic disruption of platelet-derived growth factor receptor (PDGFR) ? results in spina bifida, but the underlying mechanism has not been identified. To elucidate the cause of this birth defect in PDGFR? mutant embryos, we examined the developmental processes involved in vertebrae formation. Exposure of chick embryos to the PDGFR inhibitor imatinib mesylate resulted in spina bifida in the absence of NTDs. We next examined embryos with a tissue-specific deletion of the receptor. We found that loss of the receptor from chondrocytes did not recapitulate the spina bifida phenotype. By contrast, loss of the receptor from all sclerotome and dermatome derivatives or disruption of PDGFR?-driven phosphatidylinositol 3? kinase (PI3K) activity resulted in spina bifida. Furthermore, we identified a migration defect in the sclerotome as the cause of the abnormal vertebral development. We found that primary cells from these mice exhibited defects in PAK1 activation and paxillin localization. Taken together, these results indicate that PDGFR? downstream effectors, especially PI3K, are essential for cell migration of a somite-derived dorsal mesenchyme and disruption of receptor signaling in these cells leads to spina bifida.

Pickett, Elizabeth A.; Olsen, Gregory S.; Tallquist, Michelle D.

2010-01-01

215

Spina Bifida / Children of Korean and Vietnam Veterans  

MedlinePLUS

... financed health care benefits to certain Korea and Vietnam Veterans' birth children who have been diagnosed with ... If you are the birth child of a Vietnam Veteran and you have been diagnosed with spina ...

216

Current approaches to the urologic care of children with spina bifida.  

PubMed

Most children born with spina bifida, the most common disabling congenital abnormality, have normal renal function. If left untreated, more than half of these children will have serious renal deterioration by age 5. This deterioration is secondary to hostile neurogenic changes of the bladder. Renal development should follow a normal course when close evaluation and intervention are undertaken during the newborn period and toddler years. As children age, attention is directed to quality-of-life issues, such as the establishment of urinary and bowel continence. Teenagers face the responsibility of understanding their medical condition and should begin to assume responsibility for their own care with eventual transition to the adult health care system. This article describes the foundations of management, beginning at birth, for caring for children with spina bifida. PMID:18420000

Joseph, David B

2008-03-01

217

Discussion: 'ultrasound screening for fetal spina bifida,' by Bernard et al.  

PubMed

In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Bernard J-P, Cuckle HS, Stirnemann JJ, et al. Screening for fetal spina bifida by ultrasound examination in the first trimester of pregnancy using fetal biparietal diameter. Am J Obstet Gynecol 2012;207:306.e1-2. PMID:23021702

Macones, George A; Stamilio, David M; Odibo, Anthony; Cahill, Alison

2012-08-17

218

Parents? social adjustments in families of children with spina bifida: A theory-driven review  

Microsoft Academic Search

Objective Five theoretical hypotheses about the impact of spina bifida (SB) on parents' social adjustment in the parent-child, the marital and the family-level relationship were tested. Methods PsycInfo, Medline and reference lists were searched. This yielded 27 eligible reports. Effect sizes (Hedges' d) were computed to estimate the impact of SB. Results Overall, the effects of SB were small to

Ignace P. R. Vermaes; Jan R. M. Gerris; Jan M. A. M. Janssens

2007-01-01

219

Attention Problems and Executive Functions in Children With Spina Bifida and Hydrocephalus  

Microsoft Academic Search

This study addressed the incidence of Attention-Deficit\\/Hyperactivity Disorder (ADHD) subtypes in children with spina bifida meningomyelocele and shunted hydrocephalus (SBH) as well as differences in executive functions among these subtypes. Parent rating scales revealed that 31% of the group with SBH could be identified with AD\\/HD, mostly the Inattentive type (23%). The group with SBH differed from normal controls on

Rachel Burmeister; H. Julia Hannay; Kim Copeland; Jack M. Fletcher; Amy Boudousquie; Maureen Dennis

2005-01-01

220

Mother and Child Depressive Symptoms in Youth with Spina Bifida: Additive, Moderator, and Mediator Models  

Microsoft Academic Search

The purpose of the study was to examine the extent to which parenting behaviors influence the relation between maternal and\\u000a child depressive symptoms in youth with spina bifida and a comparison sample. Previous research has found that maternal depression\\u000a not only negatively impacts the mother–child relationship, but also places the child at risk for developing depressive symptoms.\\u000a However, certain parenting

Kriston B. Schellinger; Grayson N. Holmbeck; Bonnie S. Essner; Renae Alvarez

221

A Multimethod, Multi-Informant, and Multidimensional Perspective on Psychosocial Adjustment in Preadolescents With Spina Bifida  

Microsoft Academic Search

This study examined the psychosocial adjustment of preadolescents with spina bifida in relation to a comparison sample of able-bodied preadolescents (8- and 9-year-olds; n = 68 in each sample). The study also examined the potential clinical utility of a narrowband multimethod, multi-informant, and multidimensional perspective on the assessment of psychosocial functioning in children and adolescents with pediatric conditions. Findings revealed

Grayson N. Holmbeck; Venette C. Westhoven; Wendy Shapera Phillips; Rachael Bowers; Christine Gruse; Tina Nikolopoulos; Christine M. Wienke Totura; Kenneth Davison

2003-01-01

222

Observed and Perceived Dyadic and Systemic Functioning in Families of Preadolescents With Spina Bifida  

Microsoft Academic Search

Objective: To examine dyadic and systemic family functioning across several domains (conflict, cohesion, and stress) in families of preadolescents with spina bifida in comparison to families of able-bodied preado- lescents (8- and 9-year olds; n 68 in each sample). Methods: Mother-, father-, and child-reported questionnaire data and observational ratings of family behav- ior were employed. Results: Findings revealed significant group

Grayson N. Holmbeck; Rachael Millstein Coakley; Jennifer S. Hommeyer; Wendy E. Shapera; Venette C. Westhoven

2002-01-01

223

Biomechanical comparison of lumbar spine with or without spina bifida occulta. A finite element analysis  

Microsoft Academic Search

Study design:Biomechanical study using finite element model (FEM) of lumbar spine.Objectives:Very high coincidence of spina bifida occulta (SBO) has been reported more than in 60% of lumbar spondylolysis. The altered biomechanics due to SBO is one considerable factor for this coincidence. Thus, in this study, the biomechanical changes in the lumbar spine due to the presence of SBO were evaluated.Setting:United

K Sairyo; V K Goel; S Vadapalli; S L Vishnubhotla; A Biyani; N Ebraheim; T Terai; T Sakai

2006-01-01

224

Confirmation of microevolutionary increase in spina bifida occulta among Swiss birth cohorts  

Microsoft Academic Search

Previous studies on the prevalence of spina bifida occulta have indicated a microevolutionary increase in its frequency and\\u000a possible population differences in the prevalence of the condition. We studied the frequencies of closed and open sacral canals\\u000a at each sacral level among two birth cohorts in Switzerland. Transverse CT scans and multiplanar reconstruction images of\\u000a sacra of 95 males and

Yu Chao Lee; Lucian Bogdan Solomon; Frank Jakobus Rühli; Regula Schiess; Lena Öhrström; Thomas Sullivan; Hatem Alkadhi; Maciej Henneberg

2011-01-01

225

Incidental Spina Bifida Occulta in Functional Enuresis Observed During Laser Reflexo Therapy  

Microsoft Academic Search

The etiology of persistent functional enuresis in children is ill understood. A wide range of therapeutic modalities have been tried. During investigations preceding a trial of laser reflexo therapy in functional enuretic children aged 7 to 10 years spina bifida occulta was observed in 86.6% of subjects. The lesions were predominantly at the L5-6 level. There were no cutaneous stigmata

Veena Kalra; H. K. Palaksha

1999-01-01

226

Segmental wire fixation for lumbar spondylolysis associated with spina bifida occulta  

Microsoft Academic Search

Introduction  The effectiveness of segmental wire fixation technique in repairing lumbar spondylolysis has already been reported. However,\\u000a whether the technique can be indicated for spondylolysis associated with spina bifida, which is occasionally found with spondylolysis,\\u000a is not well known. In this study, the authors report the mid-term clinical outcome of the procedure performed in patients\\u000a with symptomatic lumbar spondylolysis associated with

Takatoshi Yamamoto; Nobuki Iinuma; Kei Miyamoto; Seiichi Sugiyama; Satoshi Nozawa; Hideo Hosoe; Katsuji Shimizu

2008-01-01

227

Postural sway at ground and bevel levels in subjects with spina bifida occulta  

Microsoft Academic Search

To assess whether the postural function is impaired by comparing the performances in upright standing at ground and bevel\\u000a levels in adult subjects with spina bifida occulta (SBO). Eighty subjects with SBO (38 with minor type and 42 with major type)\\u000a and 35 healthy control subjects participated in the study. All participants performed ten tests while standing upright on\\u000a a

Shin-Tsu Chang; Chih-Hung Ku

2007-01-01

228

Proteomic analysis of amniotic fluid of pregnant rats with spina bifida aperta  

Microsoft Academic Search

Congenital spina bifida aperta is a common congenital malformation in children and has an incidence of 1‰ to 5‰ in China. However, we currently lack specific biomarkers for screening or prenatal diagnosis and there is no method to entirely cure or prevent such defects. In this study, we used two-dimensional gel electrophoresis (2-DE)\\/mass spectrometry (MS) to characterize differentially expressed proteins

Liping Shan; Yang Fan; Hui Li; Wei Liu; Hui Gu; Fenghua Zhou; Yuan Zhengwei

229

Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida.  

PubMed

TXN2 encodes human thioredoxin 2, a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Txn2 knockout mice fail to complete neural tube closure by E10.5 and die in utero. We hypothesized that genetic variation in human TXN2 gene may alter the function of the encoded protein in a manner associated with an increased risk for neural tube defects (NTDs). A DNA re-sequencing effort of the human TXN2 gene was taken. After a variation in the promoter was identified, the transcriptional activity of different alleles was investigated. The possible association between these variations and the risk of spina bifida was further evaluated in a subset of samples obtained from a large population-based case-control study in California in two different ethnicity groups, non-Hispanic white and Hispanic white. We identified a novel promoter insertion polymorphism located 9 base pairs upstream of the transcription start site of exon 1(-9 insertion). The GA, G and GGGA insertions were associated with a marked decrease of transcriptional activity when overexpressed in both U2-OS (an osteosarcoma cell line) and 293 cells (derived from human embryonic kidney). Further analysis revealed that the GA insertion was associated with increased spina bifida risk for Hispanic whites. Our study revealed a novel Ins/Del polymorphism in the human TXN2 gene proximal promoter region that altered the transcriptional activity and is associated with spina bifida risk. This polymorphism may be a genetic modifier of spina bifida risk in this California population. PMID:19165900

Wen, Shu; Lu, Wei; Zhu, Huiping; Yang, Wei; Shaw, Gary M; Lammer, Edward J; Islam, Ana; Finnell, Richard H

2009-02-01

230

Current approaches to the urologic care of children with spina bifida  

Microsoft Academic Search

Most children born with spina bifida, the most common disabling congenital abnormality, have normal renal function. If left\\u000a untreated, more than half of these children will have serious renal deterioration by age 5. This deterioration is secondary\\u000a to hostile neurogenic changes of the bladder. Renal development should follow a normal course when close evaluation and intervention\\u000a are undertaken during the

David B. Joseph

2008-01-01

231

Cognitive functions correlate with diffusion tensor imaging metrics in patients with spina bifida cystica  

Microsoft Academic Search

Purpose  Spina bifida cystica (SBC) is a group of neurodevelopmental defects caused by improper neural tube closure, which may be responsible\\u000a for deficits in cognitive functions. The purpose of this study was to examine changes in normal appearing deep gray and white\\u000a matter brain regions in SBC patients compared with controls through diffusion tensor imaging (DTI) and correlate these changes\\u000a with

Manoj Kumar; Arti Srivastava; Shruti Agarwal; Sanjay Behari; Gyanendra K. Malik; Ram K. S. Rathore; Rakesh K. Gupta

2011-01-01

232

AN ARTIFICIAL SOMATIC-AUTONOMIC REFLEX PATHWAY PROCEDURE FOR BLADDER CONTROL IN CHILDREN WITH SPINA BIFIDA  

Microsoft Academic Search

Purpose:Neurogenic bladder is a major problem for children with spina bifida. Despite rigorous pharmacological and surgical treatment, incontinence, urinary tract infections and upper tract deterioration remain problematic. We have previously demonstrated the ability to establish surgically a skin-central nervous system-bladder reflex pathway in patients with spinal cord injury with restoration of bladder storage and emptying. We report our experience with

CHUAN-GUO XIAO; MAO-XIN DU; BING LI; ZHAO LIU; MING CHEN; ZHAO-HUI CHEN; PING CHENG; XIAO-NAN XUE; ELLEN SHAPIRO; HERBERT LEPOR

2005-01-01

233

Laparoscopic Hysteropexy in a Patient with Spina Bifida and Ventriculoperitoneal Shunt  

PubMed Central

Laparoscopic repair of pelvic organ prolapse in patients with ventriculoperitoneal shunts has not been previously described. The optimum management of patients with ventriculoperitoneal shunts undergoing laparoscopy is uncertain. We describe the case of a 21-year-old female patient with spina bifida and ventriculoperitoneal shunt who underwent laparoscopic hysteropexy for severe pelvic organ prolapse. The implications of performing laparoscopy on patients with ventriculoperitoneal shunts are reviewed along with strategies to reduce potential intraoperative complications.

Askari, Reza; Kasturi, Seshadri; Ravangard, Samadh F.

2011-01-01

234

Children with Spina Bifida are at Risk for Low Bone Density  

Microsoft Academic Search

Background  Patients with spina bifida frequently sustain lower extremity fractures which may be difficult to diagnose because they feel\\u000a little or no pain, although the relative contributions of low bone density to pain insensitivity are unclear. Routine dual-energy\\u000a xray absorptiometry (DXA) scanning is unreliable because these patients lack bony elements in the spine, and many have joint\\u000a contractures and\\/or implanted hardware.

Elizabeth A. Szalay; Asad Cheema

2011-01-01

235

Individual phenotype trait variability as genetic markers of gender susceptibility to spina bifida.  

PubMed

We compared individual trait variability in 65 male and 81 female patients with spina bifida occulta (SBO) or spina bifida aperta (SBA) against 170 male and 200 female subjects randomly selected Serbian subjects without these conditions. Variability was evaluated by direct observation of 15 homozygous recessive traits (HRT), while gender was evaluated separately. Individual trait variations between genders in SBO patients (4/15 HRT) and in SBA patients (12/15 HRT) showed remarkable differences. Individual trait variations between the male control group and SBO (9/15 HRT), between the female control group and SBO (5/15 HRT), between the male control group and SBA (8/15 HRT), between the female control group and SBA (9/15 HRT), between male SBO and SBA patients (6/15 HRT), between female SBO and SBA patients (6/15 HRT), also indicated remarkable differences. These differences could be explained by different expression of genes that may contribute to expression of spina bifida (SB). PMID:24052697

Nikolic, Dp; Cvjeticanin, S; Petronic, I; Brdar, R; Cirovic, D; Bizic, M; Milincic, Z; Karan, R

2011-06-01

236

Individual Phenotype Trait Variability as Genetic Markers of Gender Susceptibility to Spina Bifida  

PubMed Central

We compared individual trait variability in 65 male and 81 female patients with spina bifida occulta (SBO) or spina bifida aperta (SBA) against 170 male and 200 female subjects randomly selected Serbian subjects without these conditions. Variability was evaluated by direct observation of 15 homozygous recessive traits (HRT), while gender was evaluated separately. Individual trait variations between genders in SBO patients (4/15 HRT) and in SBA patients (12/15 HRT) showed remarkable differences. Individual trait variations between the male control group and SBO (9/15 HRT), between the female control group and SBO (5/15 HRT), between the male control group and SBA (8/15 HRT), between the female control group and SBA (9/15 HRT), between male SBO and SBA patients (6/15 HRT), between female SBO and SBA patients (6/15 HRT), also indicated remarkable differences. These differences could be explained by different expression of genes that may contribute to expression of spina bifida (SB).

Nikolic, DP; Cvjeticanin, S; Petronic, I; Brdar, R; Cirovic, D; Bizic, M; Milincic, Z; Karan, R

2011-01-01

237

Neurogenic bowel and continence programs for the individual with spina bifida.  

PubMed

The neurogenic bowel in the person with spina bifida has been difficult to manage. Current literature reveals very little research conducted on the outcome of continence programs in the person with spina bifida. It has different characteristics than the neurogenic bowel seen with spinal cord injury because it occurs during fetal development. Management of the neurogenic bowel to achieve continence is based upon thirteen assessment items that include stool form, individual physiologic parameters, family patterns, diet and medications. Programs are developmentally related to appropriately support the child's involvement. Continence strategies include the use of oral medication early in the day and timed sitting, suppositories or enemas later in the day at a time convenient to the family. The timing of the medications and evacuation is very important to the success. An interdisciplinary team is important in supporting the family as the child with spina bifida grows into an independent adult. The dietician and occupational therapist have invaluable insight into diet, fluids, adaptive aids and techniques that contribute to positive outcomes of the continence program. PMID:21791784

Leibold, Susan

2008-01-01

238

Wound care challenges in children and adults with spina bifida: an open-cohort study.  

PubMed

Skin breakdown is a frequent concern for individuals with spina bifida. We explored wound incidence in patients with spina bifida and how it varies across a person's life span and functional neurologic level. We examined the settings in which skin breakdown most commonly occurred, looking for evidence of chronic, non-healing wounds. We also sought to develop criteria to improve wound monitoring. We identified reported wound episodes in an open-cohort study over a 13-year period, examining the hospital and outpatient clinical records of spina bifida patients at Children's National Medical Center (CNMC). Current age, age at wound presentation, sex, weight, functional neurologic level, wound location, setting in which the wound was acquired, the development of a chronic wound, and presence of a shunt were recorded. Of the 376 patients in our clinical population, 123 (average age: 18.8 years, range: infancy-56 years) developed a total of 375 wounds; the majority of patients who developed one wound went on to develop one or more additional wounds, and 20 patients developed chronic wounds. Our data suggest that age bracket (adolescents), wheelchair use, and bare feet, as well as possibly obesity and reduced executive functioning, are key risk factors for wound development. These findings have led to a focused effort to increase wound education and prevention. In addition we report on our early experience using a wound care specialist to champion this initiative. PMID:23481886

Ottolini, Katherine; Harris, Amy B; Amling, June K; Kennelly, Ann M; Phillips, Leslie A; Tosi, Laura L

2013-01-01

239

Zur Frage des Zusammenhanges zwischen Spina bifida occulta und Wirbeltuberkulose  

Microsoft Academic Search

Zusammenfassung Bei 150 an Spondylitis tuberculosa Erkrankten wird an Hand von Röntgenbildern festgestellt, daß weder bei Erwáchsenen noch bei Kindern ein häufigeres Auftreten einer Spina fibida occulta oder anderer Wirbelsäulenvariationen zu finden ist, als dies für wirbelsäulengesunde, sog. normale Menschen in der Literatur beschrieben wurde.

Hanns Lerch

1951-01-01

240

The 894G>T variant in the endothelial nitric oxide synthase gene and spina bifida risk  

PubMed Central

The 894G>T single nucleotide polymorphism (SNP) in the endothelial NOS (NOS3) gene, has recently been associated with embryonic spina bifida risk. In this study, a possible association between the NOS3 894G>T SNP and spina bifida risk in both mothers and children in a Dutch population was examined using both a case-control design and a transmission disequilibrium test (TDT). Possible interactions between the NOS3 894G>T SNP and the MTHFR 677C>T SNP, elevated plasma homocysteine, and decreased plasma folate concentrations were also studied. The NOS3 894TT genotype did not increase spina bifida risk in mothers or children (OR 1.50, 95%CI 0.71–3.19 and OR 1.78, 95%CI 0.75–4.25, respectively). The TDT demonstrated no preferential transmission of the NOS3 894T allele (?2 = 0.06, P = 0.81). In combination with the MTHFR 677TT genotype or elevated plasma homocysteine concentrations, the NOS3 894GT/TT genotype increased maternal spina bifida risk (OR 4.52, 95%CI 1.55–13.22 and OR 3.38, 95%CI 1.46–7.84, respectively). In our study population, the NOS3 894GT/TT genotype might be a risk factor for having a spina bifida affected child in mothers who already have an impaired homocysteine metabolism.

van der Linden, Ivon J. M.; Heil, Sandra G.; den Heijer, Martin

2007-01-01

241

Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study.  

PubMed

Spina bifida refers to a collection of neural tube defects, including myelomeningocele, meningocele, and myelocele (SB(M) ), as well as lipomyelomeningocele and lipomeningocele (SB(L) ). Maternal race/ethnicity has been associated with an increased risk for spina bifida among offspring. To better understand this relationship, we evaluated different spina bifida subtypes (SB(M) vs. SB(L) ) and sub-phenotypes (anatomic level or presence of additional malformations) by maternal race/ethnicity using data from the National Birth Defects Prevention Study. This study is a large, multisite, population-based study of nonsyndromic birth defects. Prevalence estimates were obtained using data from spina bifida cases (live births, fetal deaths, and elective terminations) and total live births in the study regions. From October 1997 through December 2005, 1,046 infants/fetuses with spina bifida were delivered, yielding a prevalence of 3.06 per 10,000 live births. Differences in the prevalences of SB(M) vs. SB(L) , isolated versus non-isolated SB(M) , and lesion level in isolated SB(M) among case offspring were observed by maternal race/ethnicity. Compared to non-Hispanic (NH) White mothers, offspring of Hispanic mothers had higher prevalences of each subtype and most sub-phenotypes, while offspring of NH Black mothers generally had lower prevalences. Furthermore, differences in race/ethnicity among those with isolated SB(M) were more pronounced by sex. For instance, among male offspring, the prevalence of isolated SB(M) was significantly higher for those with Hispanic mothers compared to NH White mothers [prevalence ratio (PR): 1.55, 95% confidence interval: 1.23-1.95]. These findings provide evidence that certain spina bifida subtypes and sub-phenotypes may be etiologically distinct. PMID:22140002

Agopian, A J; Canfield, Mark A; Olney, Richard S; Lupo, Philip J; Ramadhani, Tunu; Mitchell, Laura E; Shaw, Gary M; Moore, Cynthia A

2011-12-02

242

Degree of genetic homozygosity and distribution of AB0 blood types among patients with spina bifida occulta and spina bifida aperta  

PubMed Central

Introduction Assuming that spina bifida (SB) is a genetically controlled disease, the aim of our study was to evaluate the degree of genetic homozygosity and the distribution of AB0 blood types among patients with SB occulta and SB aperta by the homozygously recessive characteristics (HRC) test. Material and methods Our study included an analysis of the presence, distribution and individual combination of 15 selected genetically controlled morpho-physiological traits in a sample of 100 patients with SB (SB occulta N = 50 and SB aperta N = 50) and a control group of individuals (N = 100). Results We found a statistically significant difference between the mean values for genetic homozygosity (SB 4.5 ±0.3; control 3.0 ±0.2, p < 0.001) and also differences in the presence of certain individual combinations of such traits. In 12 (80.0%) of the 15 observed characteristics, recessive homozygosity was expressed to a greater degree among the group of SB patients, while for 9 (60.0%) of the traits this level of difference was statistically significant (?? 2 = 266.3, p < 0.001). There was no difference in average homozygosity of such genetic markers between groups of SB occulta and SB aperta patients, but the type of individual variation in the two studied groups significantly differed. In the group of patients with SB the frequency of 0 blood group was significantly increased while B blood group was significantly decreased. Conclusions Our results clearly show that there is a populational genetic difference in the degree of genetic homozygosity and variability between the group of patients with SB and individuals without clinical manifestations, indicating a possible genetic component in the aetiopathogenesis of spina bifida.

Cvjeticanin, Suzana; Petronic, Ivana; Jekic, Biljana; Brdar, Radivoj; Damnjanovic, Tatjana; Bunjevacki, Vera; Maksimovic, Nela

2010-01-01

243

Perineal sensation: an important predictor of long-term outcome in open spina bifida  

PubMed Central

Objectives To see if perineal sensation in infants with open spina bifida is associated with a better long?term outcome, particularly in terms of survival, renal?related deaths and incontinence. Methods We conducted a prospective cohort study on a complete cohort of 117 consecutive patients with open spina bifida, whose backs were closed non?selectively at birth between 1963 and 1971. A meticulous neurological examination in infancy showed that 33 (28%) of them had perineal sensation, defined as intact sensation to pinprick in at least one dermatome on one side in the saddle area (S2–4). Data recorded within 48?h of birth and during six reviews between 1972 and 2002 were used. Details of deaths were obtained from medical records and from the Office of National Statistics. Results By December 2005, 57% (67/117) of the cohort had died. There were 50 survivors with a mean age 38?years (range 35–41). More of those with perineal sensation survived than those without (23/33 v 27/84, p<0.001). This difference was mainly caused by 19 renal deaths in those lacking perineal sensation. Crucially there were no renal?related deaths in those with perineal sensation (0/33 v 19/84, p?=?0.003). Among the survivors, those with perineal sensation were more likely than the remainder to be continent of urine and faeces (10/23 v 1/27, p<0.001 and 18/23 v 9/27, p?=?0.002 respectively). They were also more likely to be able to walk at least 50?m (11/23 v 5/27, p?=?0.027) and never to have had pressure sores (15/23 v 9/27, p?=?0.025). Conclusions A simple assessment of perineal sensation in infancy predicts long?term outcome in terms of survival, renal prognosis and incontinence in open spina bifida.

Oakeshott, P; Hunt, G M; Whitaker, R H; Kerry, S

2007-01-01

244

Can children with spina bifida and muscular dystrophy participate in their own health status evaluations?  

Microsoft Academic Search

Background  The outcomes movement has emphasized the importance of the patient in evaluating treatment outcome. However, concern has been\\u000a raised about the ability of children, particularly those with multisystem disease, to evaluate their disability.\\u000a \\u000a \\u000a \\u000a \\u000a Purpose  To determine whether children with spina bifida and muscular dystrophy and their parents agree when asked about the relative\\u000a difficulty of daily activities and the severity of

Susan C. McLimont; Janice L. Owen; James G. Wright

2010-01-01

245

Sleep problems, chronotype, and diurnal preferences in children and adults with spina bifida.  

PubMed

Spina bifida meningomyelocele (SBM) is a neural tube defect that involves dysraphism of the spinal cord and extensive reorganization of the brain. The authors assessed the relationship between chronotype, diurnal preferences, and sleep problems in individuals with SBM and healthy controls. Although individuals with SBM showed the characteristic decelerating quadratic relationship between age and chronotype, the curve was displaced, peaking at a younger age in controls compared with SBM (23.4 vs. 29.2 years). Groups did not differ in morningness-eveningness preferences. Individuals with SBM endorsed more sleep problems than controls. Further examination of the relationship between entrainment and sleep in SBM is warranted. PMID:22476778

Edelstein, Kim; Cirino, Paul T; Hasher, Lynn; Fletcher, Jack M; Dennis, Maureen

2012-04-01

246

Latex sensitization and allergy in children with spina bifida in Turkey  

Microsoft Academic Search

Purpose  The latex allergy is known as a very frequent problem of children with spina bifida (SB). The aim of this prospective study\\u000a is to determine the frequency of latex sensitization and allergy in Turkish children with SB and to evaluate the related risk\\u000a factors.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  We enrolled a total of 175 children and collected them in four groups of patients: children

Gokhan Bozkurt; Cansin Sackesen; Ersoy Civelek; Omer Kalayci; Nejat Akalan; Oguz Cataltepe

2010-01-01

247

Cognitive and functional outcome in spina bifida–Chiari II malformation  

Microsoft Academic Search

Purpose  The long-term outcome in spina bifida–Chiari II–hydrocephalus complex is poorly understood. Traditional neurosurgical outcome\\u000a measures are crude. Neuropsychological testing is increasingly important in outcome assessment. We investigated the health,\\u000a disability, lifestyle and cognitive function in adults who had myelomeningocoele closure at birth.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  Adult patients under routine follow-up were assessed in a joint neurosurgery\\/neuropsychology clinic. Patients completed lifestyle\\u000a questionnaires, the hydrocephalus

Michael D. Jenkinson; Sophie Campbell; Caroline Hayhurst; Simon Clark; Jothy Kandasamy; Maggie K. Lee; Ann Flynn; Peter Murphy; Conor L. Mallucci

2011-01-01

248

A vesicocutaneous fistula secondary to bladder calculi in a patient with spina bifida  

PubMed Central

We present a rare case of a vesicocutaneous fistula secondary to two large bladder calculi in a patient with spina bifida. A 62 year old lady presented with swelling of her right thigh and a calcified mass protruding through the subcutaneous tissues of her right groin. Urine was seen to be draining from around the area and plain radiographs and a computed topography (CT) scan confirmed the presence of two bladder calculi with a vesicocutaneous fistula. Vesicolithotomy was performed and the fistula tract left to close spontaneously. Worldwide this is only the fourth case of a bladder calculus causing a vesicocutaneous fistula.

Horsnell, Jonathan D; Kinder, Richard B

2010-01-01

249

A unifying hypothesis for hydrocephalus, Chiari malformation, syringomyelia, anencephaly and spina bifida  

PubMed Central

This work is a modified version of the Casey Holter Memorial prize essay presented to the Society for Research into Hydrocephalus and Spina Bifida, June 29th 2007, Heidelberg, Germany. It describes the origin and consequences of the Chiari malformation, and proposes that hydrocephalus is caused by inadequate central nervous system (CNS) venous drainage. A new hypothesis regarding the pathogenesis, anencephaly and spina bifida is described. Any volume increase in the central nervous system can increase venous pressure. This occurs because veins are compressible and a CNS volume increase may result in reduced venous blood flow. This has the potential to cause progressive increase in cerebrospinal fluid (CSF) volume. Venous insufficiency may be caused by any disease that reduces space for venous volume. The flow of CSF has a beneficial effect on venous drainage. In health it moderates central nervous system pressure by moving between the head and spine. Conversely, obstruction to CSF flow causes localised pressure increases, which have an adverse effect on venous drainage. The Chiari malformation is associated with hindbrain herniation, which may be caused by low spinal pressure relative to cranial pressure. In these instances, there are hindbrain-related symptoms caused by cerebellar and brainstem compression. When spinal injury occurs as a result of a Chiari malformation, the primary pathology is posterior fossa hypoplasia, resulting in raised spinal pressure. The small posterior fossa prevents the flow of CSF from the spine to the head as blood enters the central nervous system during movement. Consequently, intermittent increases in spinal pressure caused by movement, result in injury to the spinal cord. It is proposed that posterior fossa hypoplasia, which has origins in fetal life, causes syringomyelia after birth and leads to damage to the spinal cord in spina bifida. It is proposed that hydrocephalus may occur as a result of posterior fossa hypoplasia, where raised pressure occurs as a result of obstruction to flow of CSF from the head to the spine, and cerebral injury with raised pressure occurs in anencephaly by this mechanism. The current view of dysraphism is that low central nervous system pressure and exposure to amniotic fluid, damage the central nervous system. The hypothesis proposed in this essay supports the view that spina bifida is a manifestation of progressive hydrocephalus in the fetus. It is proposed that that mesodermal growth insufficiency influences both neural tube closure and central nervous system pressure, leading to dysraphism.

Williams, Helen

2008-01-01

250

Descriptive analysis of 258 emergency department visits by spina bifida patients 1 1 Abstract published: “Evaluation of and predictors of admission among 259 spina bifida patient visits to an emergency department” in Annals of Emergency Medicine 2001;38(4):S74–5  

Microsoft Academic Search

To provide a descriptive analysis of emergency department (ED) patients with spina bifida, a retrospective chart review was conducted of ED patients with spina bifida. Data describing demographics, chief complaints, diagnostics, diagnoses, and disposition were collected. There were 125 patients with 258 ED visits. The most common presenting complaints included fever (n = 55), vomiting (36), headache (32), abdominal pain

Jeffrey M. Caterino; Mark D. Scheatzle; Joyce A. D’Antonio

2006-01-01

251

Limb reconstruction using circular frames in children and adolescents with spina bifida.  

PubMed

We report the outcome of 28 patients with spina bifida who between 1989 and 2006 underwent 43 lower extremity deformity corrections using the Ilizarov technique. The indications were a flexion deformity of the knee in 13 limbs, tibial rotational deformity in 11 and foot deformity in 19. The mean age at operation was 12.3 years (5.2 to 20.6). Patients had a mean of 1.6 previous operations (0 to 5) on the affected limb. The mean duration of treatment with a frame was 9.4 weeks (3 to 26) and the mean follow-up was 4.4 years (1 to 9). There were 12 problems (27.9%), five obstacles (11.6%) and 13 complications (30.2%) in the 43 procedures. Further operations were needed in seven patients. Three knees had significant recurrence of deformity. Two tibiae required further surgery for recurrence. All feet were plantigrade and braceable. We conclude that the Ilizarov technique offers a refreshing approach to the complex lower-limb deformity in spina bifida. PMID:20595125

Kelley, S P; Bache, C E; Graham, H Kerr; Donnan, L T

2010-07-01

252

Assistive Technology Use Among Adolescents and Young Adults With Spina Bifida  

PubMed Central

Objectives. We sought to determine the use of assistive technology among a population of individuals with spina bifida. Methods. We performed a descriptive analysis of individuals aged 13 to 27 years diagnosed with myelomeningocele (n=348) using data obtained from an existing database at Children’s Hospital and Regional Medical Center, Seattle, Washington. We summarized disease characteristics, utilization of assistive technology, community and self-care independence, and other variables. Results. Eighty-four percent of the respondents lived with at least 1 of their natural parents. Fifty-seven percent used wheelchairs, 35% used braces, and 23% used walking aids. Independent self-care was a common skill, but 72% reported limited participation in structured activities. Half were aged 18 years or older; of those, only 50% had completed high school and 71% were unemployed. Those aged younger than 18 years were all still in school (100%). Conclusions. Adolescents and young adults with spina bifida rely on assistive technology and specialized care routines to maintain their health. Assistive technology use for mobility is common; little is known about secondary complications associated with use of these technologies or the use of assistive technology to address learning disabilities and other societal barriers. Underutilization of assistive technology could delay successful transitions to independent living and community participation.

Johnson, Kurt L.; Dudgeon, Brian; Kuehn, Carrie; Walker, William

2007-01-01

253

Confirmation of microevolutionary increase in spina bifida occulta among Swiss birth cohorts.  

PubMed

Previous studies on the prevalence of spina bifida occulta have indicated a microevolutionary increase in its frequency and possible population differences in the prevalence of the condition. We studied the frequencies of closed and open sacral canals at each sacral level among two birth cohorts in Switzerland. Transverse CT scans and multiplanar reconstruction images of sacra of 95 males and 96 females born in 1940-1950 and 99 males and 94 females born in 1970-1980 in Switzerland were reviewed. We found that individuals born later have significantly more open sacral arches at all sacral levels compared to those born 30-40 years earlier. When results were related to previously published data on Australian cohorts, the trend was the same, but Swiss in both cohorts were less likely to have an open section than Australians at all locations apart from S2. This study confirmed a microevolutionary trend in the opening of sacral canal among two different generations in Switzerland and demonstrated a population difference in the prevalence of spina bifida occulta. PMID:20632043

Lee, Yu Chao; Solomon, Lucian Bogdan; Rühli, Frank Jakobus; Schiess, Regula; Öhrström, Lena; Sullivan, Thomas; Alkadhi, Hatem; Henneberg, Maciej

2010-07-15

254

TheExperienceofAdolescent? WomenLivingwithSpina? BifidaPartI:?Self-Conceptand? FamilyRelationships  

Microsoft Academic Search

Adolescent women with spina bifida (SB) face unique and diverse challenges. The purpose of this qualitative component of a larger mixed-method study on adaptation was to heighten rehabilitation nurses' understanding of self-concept and family relationships during adolescence. Interviews were conducted with 31 adolescent women and analyzed for themes. The women described a range of experiences, including challenges of typical adolescence,

Melissa Hayden Bellin; J. Sawin; F. Buran; J. Brei

255

MRI Morphometric Study and Correlation with Cognitive Functions in Young Adults Shunted for Congenital Hydrocephalus Related to Spina bifida  

Microsoft Academic Search

We studied the morphometric MRI findings and their correlation with cognitive functions in a population of 10 young adults shunted for congenital hydrocephalus related to spina bifida. Morphometric MRI analysis included measurement of the ventricular dilatation index, frontal and occipital parenchymal thickness and the size of the corpus callosum. The neuropsychological status was evaluated, notably to look for a discrepancy

C. Hommet; J. P. Cottier; C. Billard; D. Perrier; P. Gillet; B. De Toffol; D. Sirinelli; P. Bertrand; A. Autret

2002-01-01

256

Constructing a Prospective Model of Psychosocial Adaptation in Young Adolescents with Spina Bifida: An Application of Optimal Data Analysis  

Microsoft Academic Search

and classification tree analysis (CTA) techniques. Results Factors best predicting psychosocial adaptation in early adolescence included (a) intrinsic motivation, (b) estimated verbal IQ, (c) behavioral conduct, (d) coping style, and (e) physical appearance. There were no significant group (spina bifida vs. able-bodied) effects. Conclusions The final classification model correctly classified 77.8% of the total sample, indicating that this model had

Rachael Millstein Coakley; Grayson N. Holmbeck; Fred B. Bryant

2006-01-01

257

PERITONEAL DIALYSIS IN CHILDREN WITH SPINA BIFIDA AND VENTRICULOPERITONEAL SHUNT: ONE CENTER'S EXPERIENCE AND REVIEW OF THE LITERATURE  

Microsoft Academic Search

? ? ? ? ? Objective: The goal of this paper was to review the vi- ability of peritoneal dialysis (PD) in patients with spina bifida and\\/or ventriculoperitoneal shunt (VPS). ? ? ? ? ? Setting: Pediatric dialysis unit in a tertiary-care hospital. ? ? ? ? ? Data Source: The course and outcome in 9 children, 5 from the

José Grunberg; Anabella Rebori; María Cristina

258

Injury Risk for Research Subjects with Spina Bifida Occulta in a Repeated Impact Study: A Case Review.  

National Technical Information Service (NTIS)

Spina bifida occulta (SBO) occurs in 18-34% of the normal U. S. population. Recently, 16.5% of normal, asymptomatic male soldier volunteer candidates in a U.S. Army Aeromedical Research Laboratory ride motion study were excluded from the study because the...

J. P. Albano S. G. Shannon N. M. Alem K. T. Mason

1996-01-01

259

A Review of the Potential for Cardiometabolic Dysfunction in Youth with Spina Bifida and the Role for Physical Activity and Structured Exercise  

PubMed Central

Children and adolescents who have decreased mobility due to spina bifida may be at increased risk for the components of metabolic syndrome, including abdominal obesity, insulin resistance, and dyslipidemia due to low physical activity. Like their nondisabled peers, adolescents with spina bifida that develop metabolic risk factors early in life have set the stage for adult disease. Exercise interventions can improve metabolic dysfunction in nondisabled youth, but the types of exercise programs that are most effective and the mechanisms involved are not known. This is especially true in adolescents with spina bifida, who have impaired mobility and physical function and with whom there have been few well-controlled studies. This paper highlights the current lack of knowledge about the role of physical activity and the need to develop exercise strategies targeting the reduction of cardiometabolic risk and improving quality of life in youth with spina bifida.

Short, Kevin R.; Frimberger, Dominic

2012-01-01

260

Prevalence of spina bifida occulta in patients with functional disorders of the lower urinary tract and its relation to urodynamic and neurophysiological measurements  

Microsoft Academic Search

OBJECTIVE--To determine the relation between neurophysiological abnormalities and the radiological detection of spina bifida occulta in patients with dysfunction of the lower urinary tract. DESIGN--Blind assessment and subsequent decoding of mixed batch of abdominal radiographs from patients with and without urological symptoms for evidence of spina bifida occulta and comparison of results with those of previous control series. SETTING--Review study

A. Fidas; H. L. MacDonald; R. A. Elton; A. McInnes; S. R. Wild; G. D. Chisholm

1989-01-01

261

Dermoid sinus and spina bifida in three dogs and a cat.  

PubMed

This case series describes four cases of concomitant dermoid sinus and spina bifida in a Chinese crested dog, two Swedish vallhunds and a Burmese cat. The diagnosis was confirmed by computed tomography, computed tomography fistulography and pathology. Two dogs that showed abnormalities during neurological examination underwent magnetic resonance imaging. One of them had imaging findings interpreted as syringohydromyelia. All the dogs underwent surgery and the outcome was considered good in all the cases. Based on clinical and pathological examination as well as diagnostic imaging findings, two of the dermoid sinuses were classified as type IV, and two of them showed a previously unreported type of dermoid sinus. This new type is suggested here as type VI. PMID:21627660

Kiviranta, A-M; Lappalainen, A K; Hagner, K; Jokinen, T

2011-06-01

262

Incidence and type of hindfoot deformities in patients with low-level spina bifida.  

PubMed

In a consecutive series of 174 children with low-level spina bifida, there was hindfoot deformity in 263 of the 348 feet; 86 were in equinus, 108 were in calcaneus, 41 were in valgus, 20 were in varus, and eight had convex pes valgus. Surgery was performed on 222 (64%) feet. The deformities were symmetric in 114 children. Spasticity causing deformity necessitated surgery in only 44 feet. Calcaneus deformity in the foot is considerably more common in patients with L4 lesions, and in these circumstances, muscle imbalance is clearly a major factor. However, many patients with calcaneus deformity had L5 or sacral lesions. This suggests that muscle imbalance is not so important a factor as has been thought in the causation of deformity in the lower limb in myelomeningocele. PMID:9600554

Frawley, P A; Broughton, N S; Menelaus, M B

263

Perinatal factors associated with neural tube defects (anencephaly [correction of anancephaly], spina bifida and encephalocele).  

PubMed

The objective of the present study was to determine the presence of risk factors for the occurrence of neural tube defects. Data for 33,535 births which occurred at Hospital do Servidor Público Estadual de São Paulo from July 1973 to December 1986 were collected in a prospective manner as recommended by "Estudo Colaborativo Latino-Americano de Malformações Congênitas" (ECLAMC, Collaborative Latin American Study on Congenital Malformations). Twenty-six cases of neural tube defects were detected (0.77/1000 births). Of these, 11 were cases of spina bifida (0.39/1000 births), 9 of anencephaly (0.27/1000 births) and 6 of encephalocele (0.18/1000 births). We observed a higher frequency of polyhydramnios, premature labor, Apgar scores of less than 7 at the first and fifth minutes, low birth weight and intrauterine growth retardation. PMID:1341003

Ogata, A J; Camano, L; Brunoni, D

264

IgE Reactivity to 14-kD and 27-kD Natural Rubber Proteins in Latex-Allergic Children with Spina bifida and Other Congenital Anomalies  

Microsoft Academic Search

We examined by immunoblotting sera from 39 latex-allergic patients, 19 from USA and 20 from Finland, including 15 children with spina bifida and 5 children with other congenital anomalies, for IgE antibodies to natural rubber latex (latex) antigens. IgE antibodies in 10 of the 12 (83%) US spina bifida patients and in 2 of the 3 Finnish spina bifida patients

Harri Alenius; Timo Palosuo; Kevin Kelly; Viswanath Kurup; Timo Reunala; Soili Mäkinen-Kiljunen; Kristiina Turjanmaa; Jordan Fink

1993-01-01

265

Patterns of participation in school-related activities and settings in children with spina bifida.  

PubMed

Abstract Purpose: To evaluate how children with spina bifida (SB) participate in school-related activities and to explore if their motor and process skills in task performance were related to their level of active participation in school. Method: Fifty children from a geographical cohort of children with SB (aged 6-14 years) and their teachers rated the children's frequency of participation in school-related activities using a Swedish adaptation of the Availability and Participation Scale. The teachers also rated each child's level of active participation with the School Function Assessment, part one. Each child's motor and process skills were evaluated with the Assessment of Motor and Process Skills. The relation between levels of active participation and motor and process skills was subjected to binary logistic regression analysis. Results: The children participated very frequently in school activities, but their level of active participation was restricted, particularly in the recess/playground setting. There was a highly significant relation between full active participation in most school settings and the children's motor and process skills. Conclusion: Children with SB need support to become more actively involved, particularly in unstructured peer activities. The school staff need to be informed that not only the motor skills but also the process skills have an impact on the children's active participation. Implications for Rehabilitation The children with spina bifida (SB) showed a low level of active participation and involvement in school settings even though their frequency of participation was high. It is of highest importance to enable children with SB to be actively involved in peer-related and unstructured activities and to encourage them to participate in both academic and societal learning. To achieve active participation, it is important to inform the school staff about how this issue is affected not only by the level of the child's motor skills but also, and probably even more so, by the level of his/her process skills. From this knowledge, individual strategies can be worked out. PMID:23350762

Peny-Dahlstrand, M; Krumlinde-Sundholm, L; Gosman-Hedstrom, G

2013-01-25

266

A two-view ultrasound CAD system for spina bifida detection using Zernike features  

NASA Astrophysics Data System (ADS)

In this work, we address a very specific CAD (Computer Aided Detection/Diagnosis) problem and try to detect one of the relatively common birth defects - spina bifida, in the prenatal period. To do this, fetal ultrasound images are used as the input imaging modality, which is the most convenient so far. Our approach is to decide using two particular types of views of the fetal neural tube. Transcerebellar head (i.e. brain) and transverse (axial) spine images are processed to extract features which are then used to classify healthy (normal), suspicious (probably defective) and non-decidable cases. Decisions raised by two independent classifiers may be individually treated, or if desired and data related to both modalities are available, those decisions can be combined to keep matters more secure. Even more security can be attained by using more than two modalities and base the final decision on all those potential classifiers. Our current system relies on feature extraction from images for cases (for particular patients). The first step is image preprocessing and segmentation to get rid of useless image pixels and represent the input in a more compact domain, which is hopefully more representative for good classification performance. Next, a particular type of feature extraction, which uses Zernike moments computed on either B/W or gray-scale image segments, is performed. The aim here is to obtain values for indicative markers that signal the presence of spina bifida. Markers differ depending on the image modality being used. Either shape or texture information captured by moments may propose useful features. Finally, SVM is used to train classifiers to be used as decision makers. Our experimental results show that a promising CAD system can be actualized for the specific purpose. On the other hand, the performance of such a system would highly depend on the qualities of image preprocessing, segmentation, feature extraction and comprehensiveness of image data.

Konur, Umut; Gürgen, Fikret; Varol, Füsun

2011-03-01

267

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse  

PubMed Central

Cranial neural tube defects (NTDs) occur in mice carrying mutant alleles of many different genes, whereas isolated spinal NTDs (spina bifida) occur in fewer models, despite being common human birth defects. Spina bifida occurs at high frequency in the Axial defects (Axd) mouse mutant but the causative gene is not known. In the current study, the Axd mutation was mapped by linkage analysis. Within the critical genomic region, sequencing did not reveal a coding mutation whereas expression analysis demonstrated significant up-regulation of grainyhead-like 2 (Grhl2) in Axd mutant embryos. Expression of other candidate genes did not differ between genotypes. In order to test the hypothesis that over-expression of Grhl2 causes Axd NTDs, we performed a genetic cross to reduce Grhl2 function in Axd heterozygotes. Grhl2 loss of function mutant mice were generated and displayed both cranial and spinal NTDs. Compound heterozygotes carrying both loss (Grhl2 null) and putative gain of function (Axd) alleles exhibited normalization of spinal neural tube closure compared with Axd/+ littermates, which exhibit delayed closure. Grhl2 is expressed in the surface ectoderm and hindgut endoderm in the spinal region, overlapping with grainyhead-like 3 (Grhl3). Axd mutants display delayed eyelid closure, as reported in Grhl3 null embryos. Moreover, Axd mutant embryos exhibited increased ventral curvature of the spinal region and reduced proliferation in the hindgut, reminiscent of curly tail embryos, which carry a hypomorphic allele of Grhl3. Overall, our data suggest that defects in Axd mutant embryos result from over-expression of Grhl2.

Brouns, Madeleine R.; De Castro, Sandra C.P.; Terwindt-Rouwenhorst, Els A.; Massa, Valentina; Hekking, Johan W.; Hirst, Caroline S.; Savery, Dawn; Munts, Chantal; Partridge, Darren; Lamers, Wout; Kohler, Eleonore; van Straaten, Henny W.; Copp, Andrew J.; Greene, Nicholas D.E.

2011-01-01

268

Peripheral neurological involvement as the first manifestation of spina bifida occulta.  

PubMed

A 42-year-old male was admitted for right-sided sciatica with asymptomatic septic arthritis of the fifth toe of the right foot. He had a history of active chronic hepatitis C and septic arthritis of the fifth toe of the left foot. His symptoms included low back pain, poorly systematized right-sided sciatica, impairment of all forms of sensation in both lower limbs, absent ankle jerks, episodes of urinary retention, urgency, and painless septic arthritis of the fifth toe of the right foot. Roentgenograms showed a spina bifida occulta of L5 and a bony erosin in the distal interphalangeal joint of the right fifth toe. Distal denervation in the territory of L5 was demonstrated by the electromyographic study. Magnetic resonance imaging disclosed an area of high signal on T1 and T2 images, located within the spinal canal opposite L4 and suggestive of an intraspinal lipoma, as well as tethering of the spinal cord in an abnormally distal position. Antimicrobial therapy was effective in ensuring resolution of the infectious arthritis. The low back pain and sciatica responded to nonsteroidal antiinflammatory drug therapy and did not recur subsequently. Many patients who have roentgenograms taken to evaluate low back pain and sciatica are found to have a spina bifida occulta. This complex birth defect involving the spinal canal, meninges and spinal cord or cauda equina can cause neurologic and/or urinary symptoms in adulthood. Magnetic resonance imaging is essential in this situation to evaluate the spinal cord and to look for an intraspinal lipoma. PMID:9476274

Da Silva, L F; Robin, S; Guégan-Massardier, E; Krzanowska, K; Mejjad, O; Vittecoq, O; Le Loet, X

1997-12-01

269

Spina Bifida  

MedlinePLUS

... acid to the diet of women of child-bearing age may significantly reduce the incidence of neural ... it is recommended that all women of child-bearing age consume 400 micrograms of folic acid daily. ...

270

Spina Bifida  

MedlinePLUS

... palate Does cleft lip or cleft palate cause problems with breastfeeding? Babies with only a cleft lip usually ... Does cleft lip or cleft palate cause speech problems? Children with cleft lip generally have normal speech. Children with ...

271

Parasitic rachipagus conjoined twins with spina bifida, diplomyelia, scoliosis, tethered cord syndrome, and ventricular septal defect--case report.  

PubMed

A 17-year-old girl presented with a rare case of parasitic rachipagus conjoined twins associated with spina bifida, diplomyelia, scoliosis, tethered cord syndrome, and ventricular septal defect. Physical examination found a well developed breast and an apophysis on the back of the patient, and neuroimaging demonstrated scoliosis, spina bifida from T8 to L5, butterfly-shaped vertebra of T6, abnormal bone behind T7, diplomyelia, and tethered cord. Successful surgical excision of the parasitic mass was performed. Histological examination discovered uterine tube, Muller's duct, bone, cartilage, and nerve tissue besides the mammary gland. Rachipagus conjoined twins are extremely rare, but should be considered if well developed abnormal tissue is found in the dorsal midline of the spine. However, the possibility of malformations in other organs in the autosite should be considered. Careful preoperative examination and refined microsurgery may provide good outcome for the patient. PMID:22027254

Zhang, Jiayong; Duan, Hongzhou; Zhang, Yang; Yi, Zhiqiang; Bao, Shengde

2011-01-01

272

Bladder carcinoma in a 31-year-old female spina bifida patient with an auto-augmented bladder  

Microsoft Academic Search

We present the case of a 31-year-old spina bifida patient presenting with a poorly differentiated T3N1M0 bladder carcinoma\\u000a with sarcomatoid differentiation in an auto-augmented bladder. She underwent a radical cystectomy and a bilateral lymph node\\u000a dissection. However, only 10 months after the onset of her symptoms, she died after major lymphatic metastases had developed\\u000a in the small pelvis. This case report

Paul W. Veenboer; Laetitia M. O. de Kort

273

Hev b 7 is a Hevea brasiliensis protein associated with latex allergy in children with spina bifida  

Microsoft Academic Search

Background: In addition to their disease-associated handicaps, patients with spina bifida (SB) are at high risk of developing latex allergy. Individuals with SB represent a special group of latex-allergic patients, inasmuch as their IgE-binding patterns differ from those of other populations of latex-allergic individuals. Two allergens strongly associated with latex allergy in patients with SB—Hev b 1 and Hev b

Birgit Wagner; Dietke Buck; Christine Hafner; Slawomir Sowka; Bodo Niggemann; Otto Scheiner; Heimo Breiteneder

2001-01-01

274

Development of a health-related quality of life instrument for use in children with spina bifida  

Microsoft Academic Search

The objective of this study was to develop a spina bifida health-related quality of life (HRQOL) instrument. Items were generated through semi-structured interviews, and reduced by frequency- importance product ranking. Validity was assessed by correlating the HRQOL score with a global question concerning the child's well-being using the Spearman's rank coefficient, and the Piers-Harris Children's Self-Concept Scale (P-H) using the

P. C. Parkin; H. M. Kirpalani; P. L. Rosenbaum; D. L. Fehlings; A. Van Nie; A. R. Willan; D. King

1997-01-01

275

Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population  

Microsoft Academic Search

A number of recent studies have demonstrated that the occurrence and recurrence risk of neural tube defects (NTD) is reduced\\u000a by folic acid supplementation before and during pregnancy. Epidemiological studies have shown low plasma folate and raised\\u000a plasma homocysteine in women with spina bifida aperta (SB) children suggesting an abnormal folate metabolism. The 5,10-methylenetetrahydrofolate\\u000a reductase (MTHFR) variant C677T, resulting in

M. C. Koch; K. Stegmann; A. Ziegler; B. Schröter; A. Ermert

1998-01-01

276

Pyonephrosis and urosepsis in a 41-year old patient with spina bifida: Case report of a preventable death  

PubMed Central

Background Urological complications are the major cause of ill health in patients with spina bifida. Urinary sepsis accounted for the majority of admissions in patients with spina bifida. As the patient grows older, changes occur in the adult bladder, leading to increases in storage pressure and consequent risk of deterioration of renal function, which may occur insidiously. Case presentation A 34-year-old male spinal bifida patient had been managing neuropathic bladder by penile sheath. Intravenous urography revealed normal kidneys. This patient was advised intermittent catheterisations. But self-catheterisation was not possible because of long, overhanging prepuce and marked spinal curvature. This patient developed repeated urine infections. Five years later, ultrasound examination of urinary tract revealed hydronephrotic right kidney with echogenic debris within the collecting system. There was no evidence of dilatation of the ureter near the vesicoureteric junction. The left kidney appeared normal. There was no evidence of calculus disease seen in either kidney. Indwelling urethral catheter drainage was established. Two years later, MAG-3 renogram revealed normal uptake and excretion by left kidney. The right kidney showed little functioning tissue. Following a routine change of urethral catheter this patient became unwell. Ultrasound examination revealed hydronephrotic right kidney containing thick hyper-echoic internal septations and debris in the right renal pelvis suspicious of pyonephrosis. Under both ultrasound and fluoroscopic guidance, an 8 French pig tail catheter was inserted into the right renal collecting system. 150?ml of turbid urine was aspirated immediately. This patient developed large left pleural effusion, collapse/consolidation of the left lower lobe, a large fluid collection in the abdomen extending into the pelvis and expired twenty days later because of sepsis and respiratory failure. Conclusion Although penile sheath drainage may be convenient for a spina bifida patient and the carers, hydronephrosis can occur insidiously. With recurrent urine infections, hydronephrotic kidney can become pyonephrosis, which is life-threatening. Therefore, every effort should be made to carry out intermittent catheterisations along with antimuscarinic drug therapy.

2012-01-01

277

Inferential ability in children with cerebral palsy, spina bifida and pragmatic language impairment.  

PubMed

The aim of the study was to investigate and compare the ability to make inferences in three groups of children ranging from 5.2 to 10.9 years: 10 children with cerebral palsy (CP), 10 children with spina bifida and hydrocephalus (SBH) and 10 children with pragmatic language impairment (PLI). The relationship between inferential and literal comprehension was investigated by analysing atypical responses. For this analysis an analytic framework was developed. The PLI group performed significantly worse on inferential questions than the CP group. It was only in the PLI group that problems with inferential questions exceeded the problems with literal questions, and the CP group even performed significantly better in this condition. Inferential comprehension was found to be related to language comprehension in the CP group, but was more related to the ability to predict future developments in the SBH- and PLI-groups. The PLI group relied more on world knowledge and associations than on text-related factors when delivering an atypical response compared to the CP group. The analysis of atypical responses proved to be a promising tool for the planning of an adequate intervention. PMID:19800759

Holck, Pernille; Sandberg, Annika Dahlgren; Nettelbladt, Ulrika

2009-10-03

278

Children with cerebral palsy, spina bifida and pragmatic language impairment: differences and similarities in pragmatic ability.  

PubMed

Pragmatically related abilities were studied in three clinical groups of children from 5 to 11 years of age; children with cerebral palsy (CP; n=10), children with spina bifida and hydrocephalus (SBH; n=10) and children with pragmatic language impairment (PLI; n=10), in order to explore pragmatic abilities within each group. A range of pragmatic, linguistic and cognitive assessments were performed, and comparisons between the groups were made. In addition, connections between variables were studied. The most salient result was the many similarities and the lack of clear boundaries between the groups. The only significant differences found concerned short-term memory and inference ability, where all three groups experienced problems but to varying extent. Different patterns of variance were found in the groups, indicating that different underlying abilities such as reception of grammar, inferential comprehension and lexical comprehension seem to affect pragmatic ability in somewhat different ways. The results suggest that the children with CP and SBH in this study shared a number of pragmatically related traits, being more similar than would be expected according to earlier research. Finally, it is suggested that pragmatic assessment is further subdivided into a socially versus a linguistically related assessment. PMID:19249190

Holck, Pernille; Nettelbladt, Ulrika; Sandberg, Annika Dahlgren

2009-02-26

279

Associations of Ethnicity and SES with IQ and Achievement in Spina Bifida Meningomyelocele  

PubMed Central

Objectives?We evaluated whether the phenotypic pattern of higher verbal than nonverbal IQ in children with spina bifida meningomyelocele (SBM) is consistent across subgroups differing in ethnicity and SES. We also explored the relation of cognitive and academic performance.?Methods?Non-Hispanic White (n = 153) and Hispanic (n = 80) children with SBM received the Stanford Binet Test of Intelligence-IV and achievement subtests of the Woodcock–Johnson. Parents completed questionnaires assessing the family environment [socioeconomic status (SES), resources, and educational opportunities].?Results?Multivariate analysis revealed that Hispanic children with lower SES had lower verbal than nonverbal scores. Hispanic children with higher SES and non-Hispanic White children demonstrated the reverse pattern. Verbal and nonverbal IQ interacted to predict reading and math performance.?Conclusions?Lower SES is associated with lower verbal IQ in economically disadvantaged Hispanic children with SBM. Academic achievement is largely correlated with verbal IQ, but children with lower verbal IQ may partially compensate with higher nonverbal ability.

Garnaat, Sarah L.; Myszka, Katherine A.; Fletcher, Jack M.; Dennis, Maureen

2010-01-01

280

Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice.  

PubMed

To develop in vivo assays for homeobox gene function in neural development, we generated transgenic mice in which the expression of a homeobox gene is altered only within the nervous system, in neurons or neuronal precursor cells. Transgenic expression of Hoxc8 did not result in gross abnormalities, while a Hoxd4 transgene caused death shortly after birth. In neural progenitor cells, the motorneuron-specific homeodomain transcription factor Isl1 induced early developmental defects, including absence of anterior neural structures, profound defects in the neuroepithelium and defective neural tube closure. A fraction of Isl1 transgenic mice exhibited spina bifida. Isl1 transgene expression was also associated with decreased proliferation and increased Pbx1 expression in the ventral neural tube. Our results suggest a function for some homeobox genes in development of the nervous system, and that cell-type- and region-specific transgenic models will be useful to identify the cellular and molecular targets of homeobox transcription factors in nervous system development. PMID:23054727

Kappen, Claudia; Yaworsky, Paul J; Muller, Yunhua L; Salbaum, J Michael

2012-09-30

281

Goal management training of executive functions in patients with spina bifida: a randomized controlled trial.  

PubMed

Executive dysfunction causes significant real-life disability for patients with spina bifida (SB). However, no previous research has been directed toward the amelioration of executive functioning deficits amongst persons with SB. Goal Management Training (GMT) is a compensatory cognitive rehabilitation approach, addressing underlying deficits in sustained attention to improve executive function. GMT has received empirical support in studies of other patient groups. The purpose of the present study was to determine the efficacy of GMT in treating subjects with SB, using inpatient intervention periods. We hypothesized post-intervention changes in scores on neuropsychological measures to reflect improved attentional control, including sustained attention and inhibitory control. Thirty-eight adult subjects with SB were included in this randomized controlled trial. Inclusion was based upon the presence of executive functioning complaints. Experimental subjects (n = 24) received 21 hr of GMT, with efficacy of GMT being compared to results of subjects in a wait-list condition (n = 14). All subjects were assessed at baseline, post-intervention, and at 6-month follow-up. Findings indicated superior effects of GMT on domain-specific neuropsychological measures and on a functional "real-life" measure, all lasting at least 6 months post-treatment. These results show that deficits in executive functioning can be ameliorated in patients with congenital brain dysfunction. PMID:23575309

Stubberud, Jan; Langenbahn, Donna; Levine, Brian; Stanghelle, Johan; Schanke, Anne-Kristine

2013-04-11

282

Upper limb motor function in young adults with spina bifida and hydrocephalus  

PubMed Central

Objective The objective of the study was to measure upper limb motor function in young adults with spina bifida meningomyelocele (SBM) and typically developing age peers. Method Participants were 26 young adults with SBM, with a Verbal or Performance IQ score of at least 70 on the Wechsler scales, and 27 age- and gender-matched controls. Four upper limb motor function tasks were performed under four different visual and cognitive challenge conditions. Motor independence was assessed by questionnaire. Results Fewer SBM than control participants obtained perfect posture and rebound scores. The SBM group performed less accurately and was more disrupted by cognitive challenge than controls on limb dysmetria tasks. The SBM group was slower than controls on the diadochokinesis task. Adaptive motor independence was related to one upper limb motor task, arm posture, and upper rather than lower spinal lesions were associated with less motor independence. Conclusions Young adults with SBM have significant limitations in upper limb function and are more disrupted by some challenges while performing upper limb motor tasks. Within the group of young adults with SBM, upper spinal lesions compromise motor independence more than lower spinal lesions.

Salman, M. S.; Jewell, D.; Hetherington, R.; Spiegler, B. J.; MacGregor, D. L.; Drake, J. M.; Humphreys, R. P.; Gentili, F.

2011-01-01

283

The influence of ankle-foot orthoses on gait and energy expenditure in spina bifida.  

PubMed

We examined the effect of ankle-foot orthoses (AFOs) on gait and energy expenditure in children with spina bifida. Nine boys and three girls, 6 to 16 years of age, took part in the study. There were four children each with L4, L5, and sacral level lesions. Each child underwent gait analysis and energy consumption studies with and without AFOs. Walking speed was faster with AFOs (mean, 58 m/min) than without (mean, 50 m/min, p < 0.01). Stride length improved significantly (p < 0.001) from 0.89 m barefoot to 1.08 m with AFOs. Double support time was decreased from 0.32 seconds barefoot to 0.28 seconds with AFOs (p < 0.05). The oxygen cost of walking was significantly better with (0.33 mL/kg/m) than without AFOs (0.41 mL/kg/m, p < 0.001). Hip flexion at initial contact was increased. Ankle kinematics were unchanged, but ankle power generation showed a significant improvement; from 0.5 W/kg barefoot to 1.3 W/kg with AFOs. Increased ankle power generation results in improved hip flexion and stride length, which contributes to increased walking speed and reduced oxygen cost. The stability conferred by the AFOs is reflected in the reduced time spent in double support. PMID:10823604

Duffy, C M; Graham, H K; Cosgrove, A P

284

Treatment of Ventriculitis with Gentamicin and Cloxacillin in Infants Born with Spina Bifida  

PubMed Central

Of 783 newborn infants with spina bifida cystica and cranium bifidum treated in the 6 years to December 1966, 11% died of ventriculitis. 24% of all deaths were due to this cause. Experience with treatment of ventriculitis with 2 of the antibiotic drugs, gentamicin and cloxacillin, during an 18-month period is presented. CSF levels were estimated during systemic and intraventricular administration of a drug and the clinical response was correlated with these levels. Of the 14 infants treated with gentamicin, the majority of whom had Gram-negative infections, 7 recovered. The 7 who died as a result of ventriculitis were mostly under 4 weeks of age. There was close correlation between the CSF levels attained and results of therapy. It was essential to give the drug intraventricularly to attain any recordable level, and to obtain the best results the systemic and intraventricular dose of the drug had to be adjusted to give CSF levels that exceeded the minimum inhibitory concentration considerably. 2 infants who recovered died later of other causes, but 4 of the 5 survivors had normal developmental attainments. No toxic effects were observed. The 7 infants treated with cloxacillin, all of whom had Gram-positive infections, survived, 3 with normal development. The importance of intraventricular administration of drugs and proper control of doses to achieve optimal therapeutic levels is emphasized.

Lorber, J.; Kalhan, S. C.; Mahgrefte, B.

1970-01-01

285

Low maternal dietary intakes of iron, magnesium, and niacin are associated with spina bifida in the offspring.  

PubMed

Evidence about the preventive effects of nutrients other than folate on the occurrence of spina bifida is scarce. Therefore, the aim of this work was to investigate the role of maternal nutritional intake and the risk of spina bifida in the offspring. In 106 cases and 181 controls, the mothers' nutrient intakes were obtained by an FFQ approximately 24 mo after conception of the index pregnancy. Energy-adjusted mean nutrient intakes were compared, and odds ratios (OR) and 95% CI were calculated. Although mean nutrient intakes were comparable to the Dutch food consumption survey data, fat, cholesterol, iron, and folate intakes were below the 1998 Dutch Recommended Daily Allowances. Case mothers had significantly lower intakes of plant proteins (7%), polysaccharides (4%), fiber (7%), iron (6%), magnesium (6%), and niacin (4%) than control mothers. Mono- and disaccharide intakes were significantly higher (6%) in the case mothers than in control mothers. The adjusted OR (95% CI) in the lowest quartiles for plant proteins was 5.4 (2.3-12.4), for fiber 3.1 (1.5-6.8), for iron 3.5 (1.4-8.3), for magnesium 1.9 (0.9-4.1), and for niacin 2.5 (1.2-5.2). Mono- and disaccharide and polysaccharide intakes in the highest quartile had ORs (95% CI) of 2.9 (1.4-6.3) and 0.5 (0.3-1.0), respectively. The nutritional intake of Dutch women from food groups containing iron and folate seems to be compromised. Low preconceptional intakes of plant proteins, iron, magnesium, and niacin are associated with a 2- to 5-fold increased risk of spina bifida. PMID:15173422

Groenen, Pascal M W; van Rooij, Iris A L M; Peer, Petronella G M; Ocké, Marga C; Zielhuis, Gerhard A; Steegers-Theunissen, Régine P M

2004-06-01

286

Is There Any Association between Spina bifida occulta and Primary Vesicoureteral Reflux?  

PubMed Central

Objective Spina bifida occulta (SBO) has been largely considered a benign entity without clinical significance; however, there has been dispute among various authorities, and some believe that the lesion may be linked with various neurologic conditions like urologic dysfunctions. Vesicoureteral reflux (VUR) and lower urinary tract dysfunction are closely related. We examined whether the existence of SBO is related to the prevalence and severity of VUR in children. Methods We investigated 359 children, 2–14 years old, referred to radiology department for obtaining voiding cystourethrogram after the first attack of febrile urinary tract infection. After treatment of infection, with written order of responsible physicians all underwent a standard voiding cystourethrogram to detect VUR and other lower urinary tract anomalies. The patients were divided into two groups: group1 patients who had not SBO and group 2 patients with SBO in postvoiding or KUB films. In each group the presence and severity of VUR was determined in relation to the location of SBO. Findings Out of 359 children, 228 (63.5%) had normal spine and 131 (36.5%) had SBO. Fifty four (23.7%) out of 228 children with normal spine had VUR and 40 (30.5%) out of 131 children with SBO had VUR. The prevalence of VUR in children without SBO and children with SBO was not statistically different. Also we compared the severity of VUR between the two groups and there was no significant difference or trend between presence of SBO and severity of reflux (Chi2 for trend). VUR was more common in children with SBO in L5-S1 (38.3%). There was no significant relation between location of SBO and prevalence of VUR. Conclusion Location of SBO and prevalence of VUR are not related.

Mehdizadeh, Mehrzad; Roohi, Azadeh; Hemami, Mohsen; Esfahani, Seyed-Taher

2010-01-01

287

Variable expressivity of congenital longitudinal radial deficiency and spinal dysraphism in monozygotic twins.  

PubMed

We report monozygotic twins with longitudinal radial hypoplasia and low (L5) spina bifida occulta, but with differing severity. There is only one previous report of similar twins. We report these identical twins with the expression of longitudinal radial hypoplasia with mirror image pattern on contralateral sides, and the association of low spina bifida occulta. PMID:16363354

Leblebicio?lu, Gürsel; Balci, Sevim; Uzümcügil, Akin

288

Injury risk for research subjects with spina bifida occulta in a repeated impact study: a case review.  

PubMed

Spina bifida occulta (SBO) occurs in 18-34% of the normal U.S. population. Recently, 16.5% of normal, asymptomatic male soldier volunteer candidates in a U.S. Army Aeromedical Research Laboratory ride motion study were excluded from the study because they had SBO at one vertebral level. Disqualifying this percentage of screened research subject candidates threatened the timely completion of the schedule-intense protocol. Although one study suggests that SBO at spinal level S1 has a higher incidence of posterior disc herniation, the preponderance of clinical literature reports that spina bifida occulta is not a medical problem. The impact literature indicates that lumbosacral vertebral bodies fracture at 7.14 kN in static compression and 20+ G during dynamic vertical impacts. In this paper, we examined the human data observed in ejection seat incidents, the rationale for excluding volunteers with single level SBO and the path of axial load transmission through the lumboscral spine. Based on the findings, we concluded that research volunteers with single level SBO are not at increased risk for injury and recommended inclusion of these volunteers in future studies involving repeated axial impacts due to ride motion. PMID:8853834

Albano, J P; Shannon, S G; Alem, N M; Mason, K T

1996-08-01

289

Mother Knows Best: Medical Record Management for Patients with Spina Bifida During the Transition from Pediatric to Adult Care  

PubMed Central

The personal health record has potential to improve health care transition for an emerging population of pediatric patients with complex chronic conditions who survive to adulthood. In this study qualitative techniques were used to assess how young adults with spina bifida and their parents interact with their medical records. Condensation and categorization strategies for inductive research based on Grounded Theory were used to analyze 1) Who is involved in record keeping 2) How the information is stored 3) What information is kept and shared among the different constituencies and 4) When patients and parents need the information. Theme analysis revealed that mothers play a central role in the medical record management of adolescents with spina bifida. The parent-maintained home based records served as a linking pin in a heterogeneous healthcare information environment. These records tended to be organized as time-lines. Both parents and patients were concerned about how best to transition health information management to adult children. Patients and parents uniformly supported the idea of accessing medical record on-line.

?sterlund, Carsten S.; Dosa, Nienke P.; Smith, Catherine Arnott

2005-01-01

290

Neurological defects of the voiding reflex arcs in chronic urinary retention and their relation to spina bifida occulta.  

PubMed

A group of 37 patients (24 female and 13 male) with chronic urinary retention and without demonstrable mechanical obstruction had neurophysiological measurements of their lower urinary tracts to detect any neurological abnormality which might relate to the disorder. These consisted of measurements of the electrosensitivity of the dorsal nerve of the penis/clitoris and of the urethra, measurement of the sacral reflex latencies (SRL) from dorsal nerve to urethra and to anus and between urethra and anus and EMG studies of the urethral and anal sphincters. The results suggest that female patients in particular have significant neurogenic defects in the voiding reflex arcs which find their clinical expression in detrusor underactivity with urinary retention. Plain X-rays of the renal tracts (KUB films) were also studied for the presence of spina bifida occulta. The prevalence of this defect was significantly higher than in normal controls, suggesting that in some of these patients the nerve defect might be related to a tethered cord in association with spina bifida occulta. PMID:2645967

Fidas, A; MacDonald, H L; Elton, R A; McInnes, A; Chisholm, G D

1989-01-01

291

Mother knows best: medical record management for patients with spina bifida during the transition from pediatric to adult care.  

PubMed

The personal health record has potential to improve health care transition for an emerging population of pediatric patients with complex chronic conditions who survive to adulthood. In this study qualitative techniques were used to assess how young adults with spina bifida and their parents interact with their medical records. Condensation and categorization strategies for inductive research based on Grounded Theory were used to analyze 1) Who is involved in record keeping 2) How the information is stored 3) What information is kept and shared among the different constituencies and 4) When patients and parents need the information. Theme analysis revealed that mothers play a central role in the medical record management of adolescents with spina bifida. The parent-maintained home based records served as a linking pin in a heterogeneous healthcare information environment. These records tended to be organized as time-lines. Parent and patients were concerned about how best to transition their health information management from parent to adult children. Patients and parents uniformly supported the idea of having access to the medical record on-line. PMID:16779106

Østerlund, Carsten S; Dosa, Nienke P; Arnott Smith, Catherine

2005-01-01

292

Cost-benefit analysis of targeted ultrasonography for prenatal detection of spina bifida in patients with an elevated concentration of second-trimester maternal serum ?-fetoprotein  

Microsoft Academic Search

Objective: The objectives of this study were to examine (1) the diagnostic accuracy requirements (from the cost-benefit point of view) of targeted ultrasonography versus genetic amniocentesis for prenatal detection of spina bifida in women with an elevated level of maternal serum ?-fetoprotein, (2) the ultrasonographic accuracy of previously published studies from the cost-benefit point of view, and (3) the possible

Anthony M. Vintzileos; Cande V. Ananth; Allan J. Fisher; John C. Smulian; Debra Day-Salvatore; Tryfon Beazoglou; Robert A. Knuppel

1999-01-01

293

Inter-Tester Reliability and Precision of Manual Muscle Testing and Hand-Held Dynamometry in Lower Limb Muscles of Children with Spina Bifida  

ERIC Educational Resources Information Center

Reliability and measurement precision of manual muscle testing (MMT) and hand-held dynamometry (HHD) were compared for children with spina bifida. Strength measures were obtained of the hip flexors, hip abductors, and knee extensors of 20 children (10 males, 10 females; mean age 9 years 10 months; range: 5 to 15 years) by two experienced physical…

Mahony, Kate; Hunt, Adrienne; Daley, Deborah; Sims, Susan; Adams, Roger

2009-01-01

294

Complications of Benchekroun vesicostomy in a spina bifida patient: severe stenosis requiring permanent suprapubic cystostomy, recurrent vesical calculi and abdominal hernia containing ileocystoplasty - a case report  

Microsoft Academic Search

INTRODUCTION: In female patients with neuropathic bladder, the urethra is closed permanently in order to avoid urine leak. Then Benchekroun hydraulic ileal valve is attached to urinary bladder, thus providing a continent stoma for performing intermittent catheterisations. CASE PRESENTATION: We present a female patient with spina bifida who underwent Benchekroun continent vesicostomy in 1993. This patient developed severe stenosis of

Subramanian Vaidyanathan; Bakul M Soni; Gurpreet Singh; Peter L Hughes; Paul Mansour; Tun Oo

2009-01-01

295

Social Cognitive Functioning and Social Competence in Children and Adolescents with Spina Bifida and Hydrocephalus: Social Cognitive Neuroscience As a Model  

Microsoft Academic Search

The purpose of the current study was to examine social cognition in children with spina bifida and congenital hydrocephalus (SBH) and to determine whether deficits in these domains are associated with poor social competence, utilizing concepts from social cognitive neuroscience. To build upon extant literature, multi-method assessments, multi-informant data, and a developmental, biopsychosocial perspective were utilized. Distinct aspects of social

Caitlin Reid Roache

2012-01-01

296

On the allergenicity of Hev b 1 among health care workers and patients with spina bifida allergic to natural rubber latex  

Microsoft Academic Search

Background: Recent studies have caused much controversy about the prevalence of IgE antibodies to Hev b 1 among health care workers (HCWs) and patients with spina bifida (SB) who are allergic to latex. This investigation was carried out to verify the results reported. Method: Serum samples from 140 patients with SB as well as from 105 HCWs allergic to latex

Zhiping Chen; Reinhold Cremer; Anton Posch; Monika Raulf-Heimsoth; Hans-Peter Rihs; Xaver Baur

1997-01-01

297

Inter-Tester Reliability and Precision of Manual Muscle Testing and Hand-Held Dynamometry in Lower Limb Muscles of Children with Spina Bifida  

ERIC Educational Resources Information Center

|Reliability and measurement precision of manual muscle testing (MMT) and hand-held dynamometry (HHD) were compared for children with spina bifida. Strength measures were obtained of the hip flexors, hip abductors, and knee extensors of 20 children (10 males, 10 females; mean age 9 years 10 months; range: 5 to 15 years) by two experienced physical…

Mahony, Kate; Hunt, Adrienne; Daley, Deborah; Sims, Susan; Adams, Roger

2009-01-01

298

Current status of prenatal management of fetal spina bifida in the world: worldwide cooperative survey on the medico-ethical issue  

Microsoft Academic Search

IntroductionThe management of congenital CNS anomalies differs among countries. This paper reports on a worldwide survey of individual experience and regimens for treating spina bifida (SB) in different patient populations and cultural backgrounds. Ten representative members of the International Society for Pediatric Neurosurgery (ISPN) in individual countries registered their experience, prenatal management, and care system for SB. The information collected

Shizuo Oi

2003-01-01

299

Postural sway at ground and bevel levels in subjects with spina bifida occulta  

PubMed Central

To assess whether the postural function is impaired by comparing the performances in upright standing at ground and bevel levels in adult subjects with spina bifida occulta (SBO). Eighty subjects with SBO (38 with minor type and 42 with major type) and 35 healthy control subjects participated in the study. All participants performed ten tests while standing upright on a platform at ground level (0°, baseline) and on a beveled surface (with their feet in dorsiflexion and plantarflexion at 10° and 20°). Tests were done with their eyes open and closed. The postural sway was examined using a force platform (CATSYS, Danish) that records sway intensity and velocity. Sway intensity and sway velocity were universally associated with group, degree of bevel, open- or closed-eyes condition, and dorsiflexion or plantarflexion after adjusting for age and gender. With respect to sway intensity, the differences of minor or major SBO group were significantly decreased at different bevel degrees when compared with control groups, whereas the differences between minor and major SBO were significant differences at 10° and 20°. With respect to sway velocity, the differences of major SBO group were significantly decreased at different bevel degrees when compared with minor SBO and control groups, whereas the difference in minor SBO was only significant at 0° when compared with control. Group differences (minor SBO vs. control, major SBO vs. control) showed a significant decrease in sway velocity when comparing at 10° than at 0° and at 20° than at 0°. In all subjects with SBO, the sway intensity/velocity values obtained with open eyes and with plantarflexion had lower values, when compared with values obtained with closed eyes and with dorsiflexion. This study supports the hypothesis that SBO impairs control of postural sway in both the resting upright and stressful postures. Our results imply that the larger the bone defect at the lumbosacral midline, the more the group differences in different stressful conditions. Both velocity and intensity were able to reflect the function of the postural sway from our results. This is the first report to add the bevel degree and foot position, as well as visual input as being the part of the study in investigating the postural sway.

Ku, Chih-Hung

2006-01-01

300

Risk of Spina Bifida and Maternal Cigarette, Alcohol, and Coffee Use during the First Month of Pregnancy  

PubMed Central

This study was conducted to assess the association between the risks of spina bifida (SB) in relation to cigarette, alcohol, and caffeine consumption by women during the first month of pregnancy. Between 1988–2012, this multi-center case-control study interviewed mothers of 776 SB cases and 8,756 controls about pregnancy events and exposures. We evaluated cigarette smoking, frequency of alcohol drinking, and caffeine intake during the first lunar month of pregnancy in relation to SB risk. Logistic regression models were used to calculate adjusted odds ratios and 95% confidence intervals. Levels of cigarette smoking (1–9 and ?10/day), alcohol intake (average ?4 drinks/day) and caffeine intake (<1, 1, and ?2 cups/day) were not likely to be associated with increased risk of SB. Further, results were similar among women who ingested less than the recommended amount of folic acid (400 ?g/day).

Benedum, Corey M.; Yazdy, Mahsa M.; Mitchell, Allen A.; Werler, Martha M.

2013-01-01

301

The experience of adolescent women living with spina bifida part I: self-concept and family relationships.  

PubMed

Adolescent women with spina bifida (SB) face unique and diverse challenges. The purpose of this qualitative component of a larger mixed-method study on adaptation was to heighten rehabilitation nurses' understanding of self-concept and family relationships during adolescence. Interviews were conducted with 31 adolescent women and analyzed for themes. The women described a range of experiences, including challenges of typical adolescence, specific concerns about living with SB, school-based stressors, and incidences of teasing and bullying. The overall self-concept was primarily positive, despite the diverse stressors encountered. A significant source of strength was the close relationships with parents, although an undercurrent of tension related to independence was also expressed. Results from this study support the need for rehabilitation nurses to address not only the functional status but also the well-being and psychosocial challenges of adolescent women with SB. PMID:17432634

Bellin, Melissa Hayden; Sawin, Kathleen J; Roux, Gayle; Buran, Constance F; Brei, Timothy J

302

Left-sided Poland's syndrome in a girl with rare associations like spina bifida and diaphragmatic hernia.  

PubMed

Poland's syndrome is a rare congenital anomaly characterised by partial or complete absence of sternocostal head of pectoralis major muscle and anomalies of ipsilateral hand and digits. Other associated anomalies involving anterior thoracic wall, breast, diaphragm and vertebrae have also been reported in various cases. We report a case of a 10-year-old girl, with features of left-sided Poland's syndrome associated with spina bifida, dextroposition of the heart and left-sided diaphragmatic hernia. These are rare associations of Poland's syndrome. She was investigated with chest X-ray, contrast-enhanced CT of the thorax, ultrasonography of abdomen and echocardiography which helped in arriving at an accurate diagnosis and assessing all the associated abnormalities. PMID:24057335

C, Sunitha V; Narayanan, Sathya; Nair, Pradeep Pankajakshan; Prakash, Manikka Lakshmanan

2013-09-20

303

Auditory interhemispheric transfer in relation to patterns of partial agenesis and hypoplasia of the corpus callosum in spina bifida meningomyelocele  

PubMed Central

Spina bifida meningomyelocele with hydrocephalus (SBM) is commonly associated with anomalies of the corpus callosum (CC). We describe MRI patterns of regional CC agenesis and relate CC anomalies to functional laterality based on a dichotic listening test in 90 children with SBM and 27 typically developing controls. Many children with SBM (n = 40) showed regional CC anomalies in the form of agenesis of the rostrum and0or splenium, and a smaller number (n = 20) showed hypoplasia (thinning) of all CC regions (rostrum, genu, body, and splenium). The expected right ear advantage (REA) was exhibited by normal controls and children with SBM having a normal or hypoplastic splenium. It was not shown by children with SBM who were left handed, missing a splenium, or had a higher level spinal cord lesion. Perhaps the right hemisphere of these children is more involved in processing some aspects of linguistic stimuli.

Hannay, H. Julia; Walker, Amy; Dennis, Maureen; Kramer, Larry; Blaser, Susan; Fletcher, Jack M.

2009-01-01

304

Genetic Association Study of Putative Functional Single Nucleotide Polymorphisms of Genes in Folate Metabolism and Spina Bifida  

PubMed Central

OBJECTIVE We tested putative functional single nucleotide polymorphisms (SNPs) in genes which regulate the folate/homocysteine metabolism pathway for their contribution to spina bifida (SB) susceptibility. STUDY DESIGN The study consisted of 610 unrelated simplex SB patient families. Genotypes of 46 SNPs located in the coding sequence or promoter region of 11 genes were investigated. Associations between transmission of alleles and SB in the offspring were examined using the reconstruction-combined transmission disequilibrium test. RESULTS Significant association of SNP rs5742905 in cystathionine-?-synthase (CBS), rs1643649 in dihydrofolate reductase (DHFR), rs2853533 in thymidylate synthetase (TYMS), and rs3737965 in methylene-tetrahydrofolate-reductase (MTHFR) was found (p= 0.015, 0.041, 0.021, and 0.007 respectively). CONCLUSION Transmission disequilibrium of SNP alleles in CBS, DHFR, MTHFR and TYMS confers an increased susceptibility to SB.

Martinez, Carla A.; Northrup, Hope; Lin, Jone-Ing; Morrison, Alanna C.; Fletcher, Jack M.; Tyerman, Gayle H.; Au, Kit Sing

2009-01-01

305

Medical and psychosocial problems in middle-aged spina bifida patients: survey among members of the Dutch patients' association.  

PubMed

Abstract Purpose: To identify physical, emotional and psychosocial issues in the older person with spina bifida (SB). Method: Members of the Dutch patients' association aged >25 years (n?=?184) were asked to complete a questionnaire. This survey contained questions on physical and psychosocial complaints, as well as problems regarding social participation. Results: A total of 61 people (33.2%) with a median age of 45 years (IQR 33.5-60.0) years responded. During the previous 5 years, 86.9% experienced new physical complaints, whereas only 13.1% remained free of new complaints. 50.8% of the persons had new bladder problems and 44.1% had bowel complaints. Older persons more often had physical complaints. New musculoskeletal problems occurred in 75.4%. Psychological problems were common (78.7%). Overall psychological problems were not associated with gender, hydrocephalus or age. Social participation was good, with 90.2% of persons taking part in some type of social activity. Conclusions: In this study, a majority of adult persons with SB reported newly arising physical and psychological problems during the previous 5 years. Given the large number and diversity of the newly emerging problems after adolescence, regular and multidisciplinary surveillance of adult persons with SB is recommended. Implications for Rehabilitation Adults with spina bifida often disappear from follow-up, or are forced to take care of their follow-up themselves. According to a survey carried out among adult SB-patients from the general community, these persons continued to struggle with many physical and psychosocial problems. Given the high number of psychosocial problems in this sample of patients, psychosocial counseling could be beneficial during follow-up. This paper adds to the body of evidence indicating that multidisciplinary follow-up for SB-patients could be beneficial, also when patients grow beyond the age of 18 years. PMID:23763470

Veenboer, Paul W; Procee, Anke I; Verheijden, Johannes M A; Bosch, J L H Ruud; van Asbeck, Floris W A; de Kort, Laetitia M O

2013-06-13

306

Unpredicted spontaneous extrusion of a renal calculus in an adult male with spina bifida and paraplegia: report of a misdiagnosis. Measures to be taken to reduce urological errors in spinal cord injury patients  

Microsoft Academic Search

BACKGROUND: A delay in diagnosis or a misdiagnosis may occur in patients with spinal cord injury (SCI) or spinal bifida as typical symptoms of a clinical condition may be absent because of their neurological impairment. CASE PRESENTATION: A 29-year old male, who was born with spina bifida and hydrocephalus, became unwell and developed a swelling and large red mark in

Subramanian Vaidyanathan; Peter L Hughes; Bhakul M Soni; Gurpreet Singh; Paul Mansour; Pradipkumar Sett

2001-01-01

307

Identification and Characterization of an Xq26–q27 Duplication in a Family with Spina Bifida and Panhypopituitarism Suggests the Involvement of Two Distinct Genes  

Microsoft Academic Search

We investigated a family with a duplication, dup(X)q26–q27, that was present in two brothers, their mother, and their maternal grandmother. The brothers carrying the duplication displayed spina bifida and panhypopituitarism, whereas a third healthy brother inherited the normal X chromosome. Preferential inactivation of the X chromosome containing the duplication was evident in healthy carrier females. We determined the boundaries of

Frans A. Hol; Marga T. Schepens; Sylvia E. C. van Beersum; Elena Redolfi; Maurizio Affer; Paolo Vezzoni; Ben C. J. Hamel; Pamela S. Karnes; Edwin C. M. Mariman; Ileana Zucchi

2000-01-01

308

miR-9*- and miR-124a-Mediated switching of chromatin remodelling complexes is altered in rat spina bifida aperta.  

PubMed

Neural tube defects (NTDs) are complex congenital malformations resulting from incomplete neurulation. Our previous work has demonstrated that motor and sensory neurons develop defectively in rat embryos with spina bifida aperta. To identify whether neural development-associated miRNAs play a role in the neurological deficits of NTDs, we screened a panel of neural development-related miRNAs, including miR-9, miR-9*, miR-124a, miR-10a, miR10b, miR-34a, miR-221 and miR-222, in the spinal cords of rats with retinoic acid-induced spina bifida aperta. We discovered that the expression of miR-9, miR-9* and miR-124a was specifically down-regulated compared to spinal cords without spina bifida. To further clarify whether down-regulation of miR-9* and miR-124a contributes to the neurological deficits of NTDs, we investigated the levels of genes involved in switching in the subunit composition of Swi/Snf-like BAF (Brg/Brm associated factor) complexes modulated by miR-9* and miR-124a and neuronal differentiation. In addition to the down-regulation of miR-9* and miR-124a expression, we also observed increased expression of repressor element silencing transcription factor (REST) and BAF53a and decreased expression of BAF53b, Brg1 and NeuroD1. Our results suggest that REST-regulated miR-9*- and the miR-124a-mediated chromatin remodelling regulatory mechanism may participate in the neuronal deficits of spina bifida. PMID:23677776

Wei, Xiaowei; Li, Hui; Miao, Jianing; Liu, Bo; Zhan, Yue; Wu, Di; Zhang, Yi; Wang, Lili; Fan, Yang; Gu, Hui; Wang, Weilin; Yuan, Zhengwei

2013-05-16

309

Purification and Partial Amino Acid Sequencing of a 27-kD Natural Rubber Allergen Recognized by Latex-Allergic Children with Spina Bifida  

Microsoft Academic Search

We purified from natural rubber latex (NRL) by means of high-performance liquid chromatography a 27-kD protein, recognized characteristically by IgE in sera from latex-allergic children with spina bifida or other congenital anomalies and histories of multiple surgeries. N-terminal sequence analysis of the purified 27-kD protein was unsuccessful suggesting that its N-terminus is blocked. To obtain internal sequence information from the

Harri Alenius; Nisse Kalkkinen; Matti Lukka; Kristiina Turjanmaa; Timo Reunala; Soili Mäkinen-Kiljunen; Timo Palosuo

1995-01-01

310

Neurophysiological measurements in patients with genuine stress incontinence of urine and the relation of neurogenic defects to the presence of spina bifida occulta.  

PubMed

Neurophysiological measurements comprising surface electromyography (EMG) of the urethral and anal sphincters, measurement of the sensory thresholds of the dorsal nerve (DN) of the clitoris and the urethra and sacral reflex latencies from the dorsal nerve to urethra and anus and from the urethra to anus were performed in 44 females with genuine stress incontinence, in order to detect any relationship between the clinical disorder and a neurogenic defect in the innervation of the muscles involved in maintaining continence. Plain X-rays of the renal tracts (KUB films) were also studied to establish whether the prevalence of spina bifida occulta was increased in this group of patients and was a likely explanation for the nerve defects. Forty-three patients were found to have abnormal neurophysiological responses and the prevalence of spina bifida occulta was 50%, which compares with a prevalence of 17% in normal female controls. Genuine stress incontinence appears to be at least partly associated with defective innervation of the lower urinary tract and it is likely that in some cases the defect may be related to the presence of spina bifida occulta. PMID:3044478

Fidas, A; MacDonald, H L; Elton, R A; McInnes, A; Brown, A; Chisholm, G D

1988-07-01

311

[Unilateral spondylolysis with spina bifida occulta of lumbar spine--case report and review of the literature].  

PubMed

Unilateral spondylolysis and midline defects in the posterior spinal elements attributable to spina bifida occulta (SBO) result in the unilateral floating of the vertebral arch. We report a patient with unilateral spondylolysis associated with SBO in the lumbar spine and review the literature. This 71-year-old male experienced severe left leg pain and lumbago that worsened upon walking. Radiographic studies revealed SBO and unilateral spondylolysis of L5. The dural sac and left L5 nerve root were compressed by the organization of tissues around the spondylolysis. As his symptoms failed to respond to conservative treatment, he underwent unilateral laminectomy without fusion. At operation, the left lamina of L5 was floating and unstable; the right lamina was stable. Medial facetectomy at L4/5 and excision of the left floating lamina of L5 were performed. For satisfactory decompression of the dural sac and left L5 nerve root, the cartilaginous fibrous tissue around the lysis was removed. His symptoms disappeared immediately after surgery. Although long-term follow-up is necessary, we suggest that unilateral microdecompression without fusion is a useful method to treat patients with unilateral spondylolysis with SBO. PMID:16277227

Kim, Kyongsong; Isu, Toyohiko; Matsumoto, Ryouji; Miyamoto, Michiyuki; Isobe, Masanori

2005-11-01

312

A girl with spina bifida, an extra leg, and ectopic intestinal loops--a "foetus in foetu" or a whim of the neural crest?  

PubMed

This article describes a girl with an extra leg attached to her lower back, combined with a spina bifida and a myelomeningocele. Despite lacking sensory or motor functions, the leg grew proportionately with the rest of the body. The bony structures were almost normal. A cross section showed fat tissue with some centrally situated blood vessels, nerve bundles, and muscular fragments. Proximally, an isolated colon loop was found. The extra leg and intestine respected the dorsal fascia, without connection with the peritoneal or retroperitoneal compartments. The finding is discussed with reference to existing hypotheses for limb formation. PMID:17684699

Lende, G; Wendemu, W; Mørk, S; Wester, K

2007-08-09

313

Percutaneous fetoscopic patch closure of human spina bifida aperta: advances in fetal surgical techniques may obviate the need for early postnatal neurosurgical intervention  

Microsoft Academic Search

Background  A percutaneous minimally invasive fetoscopic approach was attempted for closure of a spina bifida aperta in two fetuses with\\u000a L5 lesions. The goal was to obviate the need for postnatal neurosurgery to manage this condition.\\u000a \\u000a \\u000a \\u000a Methods and Results  The percutaneous fetoscopic procedures were performed by a two-layer approach at respectively 22 ± 2 and 22 ± 4 weeks of gestation.\\u000a The fetuses were delivered respectively at

Thomas Kohl; Kristina Tchatcheva; Waltraut Merz; Hans C. Wartenberg; Axel Heep; Andreas Müller; Axel Franz; Rüdiger Stressig; Winfried Willinek; Ulrich Gembruch

2009-01-01

314

Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration  

PubMed Central

Spina bifida (SB) patients afflicted with myelomeningocele typically possess a neurogenic urinary bladder and exhibit varying degrees of bladder dysfunction. Although surgical intervention in the form of enterocystoplasty is the current standard of care in which to remedy the neurogenic bladder, it is still a stop-gap measure and is associated with many complications due to the use of bowel as a source of replacement tissue. Contemporary bladder tissue engineering strategies lack the ability to reform bladder smooth muscle, vasculature, and promote peripheral nerve tissue growth when using autologous populations of cells. Within the context of this study, we demonstrate the role of two specific populations of bone marrow (BM) stem/progenitor cells used in combination with a synthetic elastomeric scaffold that provides a unique and alternative means to current bladder regeneration approaches. In vitro differentiation, gene expression, and proliferation are similar among donor mesenchymal stem cells (MSCs), whereas poly(1,8-octanediol-cocitrate) scaffolds seeded with SB BM MSCs perform analogously to control counterparts with regard to bladder smooth muscle wall formation in vivo. SB CD34+ hematopoietic stem/progenitor cells cotransplanted with donor-matched MSCs cause a dramatic increase in tissue vascularization as well as an induction of peripheral nerve growth in grafted areas compared with samples not seeded with hematopoietic stem/progenitor cells. Finally, MSC/CD34+ grafts provided the impetus for rapid urothelium regeneration. Data suggest that autologous BM stem/progenitor cells may be used as alternate, nonpathogenic cell sources for SB patient-specific bladder tissue regeneration in lieu of current enterocystoplasty procedures and have implications for other bladder regenerative therapies.

Sharma, Arun K.; Bury, Matthew I.; Fuller, Natalie J.; Marks, Andrew J.; Kollhoff, David M.; Rao, Manoj V.; Hota, Partha V.; Matoka, Derek J.; Edassery, Seby L.; Thaker, Hatim; Sarwark, John F.; Janicki, Joseph A.; Ameer, Guillermo A.; Cheng, Earl Y.

2013-01-01

315

Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration.  

PubMed

Spina bifida (SB) patients afflicted with myelomeningocele typically possess a neurogenic urinary bladder and exhibit varying degrees of bladder dysfunction. Although surgical intervention in the form of enterocystoplasty is the current standard of care in which to remedy the neurogenic bladder, it is still a stop-gap measure and is associated with many complications due to the use of bowel as a source of replacement tissue. Contemporary bladder tissue engineering strategies lack the ability to reform bladder smooth muscle, vasculature, and promote peripheral nerve tissue growth when using autologous populations of cells. Within the context of this study, we demonstrate the role of two specific populations of bone marrow (BM) stem/progenitor cells used in combination with a synthetic elastomeric scaffold that provides a unique and alternative means to current bladder regeneration approaches. In vitro differentiation, gene expression, and proliferation are similar among donor mesenchymal stem cells (MSCs), whereas poly(1,8-octanediol-cocitrate) scaffolds seeded with SB BM MSCs perform analogously to control counterparts with regard to bladder smooth muscle wall formation in vivo. SB CD34(+) hematopoietic stem/progenitor cells cotransplanted with donor-matched MSCs cause a dramatic increase in tissue vascularization as well as an induction of peripheral nerve growth in grafted areas compared with samples not seeded with hematopoietic stem/progenitor cells. Finally, MSC/CD34(+) grafts provided the impetus for rapid urothelium regeneration. Data suggest that autologous BM stem/progenitor cells may be used as alternate, nonpathogenic cell sources for SB patient-specific bladder tissue regeneration in lieu of current enterocystoplasty procedures and have implications for other bladder regenerative therapies. PMID:23431178

Sharma, Arun K; Bury, Matthew I; Fuller, Natalie J; Marks, Andrew J; Kollhoff, David M; Rao, Manoj V; Hota, Partha V; Matoka, Derek J; Edassery, Seby L; Thaker, Hatim; Sarwark, John F; Janicki, Joseph A; Ameer, Guillermo A; Cheng, Earl Y

2013-02-19

316

Copy number variation analysis implicates the cell polarity gene glypican 5 as a human spina bifida candidate gene.  

PubMed

Neural tube defects (NTDs) are common birth defects of complex etiology. Family and population-based studies have confirmed a genetic component to NTDs. However, despite more than three decades of research, the genes involved in human NTDs remain largely unknown. We tested the hypothesis that rare copy number variants (CNVs), especially de novo germline CNVs, are a significant risk factor for NTDs. We used array-based comparative genomic hybridization (aCGH) to identify rare CNVs in 128 Caucasian and 61 Hispanic patients with non-syndromic lumbar-sacral myelomeningocele. We also performed aCGH analysis on the parents of affected individuals with rare CNVs where parental DNA was available (42 sets). Among the eight de novo CNVs that we identified, three generated copy number changes of entire genes. One large heterozygous deletion removed 27 genes, including PAX3, a known spina bifida-associated gene. A second CNV altered genes (PGPD8, ZC3H6) for which little is known regarding function or expression. A third heterozygous deletion removed GPC5 and part of GPC6, genes encoding glypicans. Glypicans are proteoglycans that modulate the activity of morphogens such as Sonic Hedgehog (SHH) and bone morphogenetic proteins (BMPs), both of which have been implicated in NTDs. Additionally, glypicans function in the planar cell polarity (PCP) pathway, and several PCP genes have been associated with NTDs. Here, we show that GPC5 orthologs are expressed in the neural tube, and that inhibiting their expression in frog and fish embryos results in NTDs. These results implicate GPC5 as a gene required for normal neural tube development. PMID:23223018

Bassuk, Alexander G; Muthuswamy, Lakshmi B; Boland, Riley; Smith, Tiffany L; Hulstrand, Alissa M; Northrup, Hope; Hakeman, Matthew; Dierdorff, Jason M; Yung, Christina K; Long, Abby; Brouillette, Rachel B; Au, Kit Sing; Gurnett, Christina; Houston, Douglas W; Cornell, Robert A; Manak, J Robert

2012-12-07

317

Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure.  

PubMed

Lumbosacral spina bifida is a common debilitating birth defect whose multiple causes are poorly understood. Here, we provide the first genetic delineation of cholinergic nicotinic receptor alpha7 (Chrna7) expression and link the ablation of the Chrna7 cell lineage to this condition in the mouse. Using homologous recombination, an IRES-Cre bi-cistronic cassette was introduced into the 3' noncoding region of Chrna7 (Chrna7:Cre) for identifying cell lineages expressing this gene. This lineage first appears at embryonic day E9.0 in rhombomeres 3 and 5 of the neural tube and extends to cell subsets in most tissues by E14.5. Ablation of the Chrna7:Cre cell lineage in embryos from crosses with conditionally expressed attenuated diphtheria toxin results in precise developmental defects including omphalocele (89%) and open spina bifida (SB; 80%). We hypothesized that like humans, this defect would be modified by environmental compounds not only folic acid or choline but also nicotine. Prenatal chronic oral nicotine administration substantially worsened the defect to often include the rostral neural tube. In contrast, supplementation of the maternal diet with 2% choline decreased SB prevalence to 38% and dramatically reduced the defect severity. Folic acid supplementation only trended towards a reduced SB frequency. The omphalocele was unaffected by these interventions. These studies identify the Chrna7 cell lineage as participating in posterior neuropore closure and present a novel model of lower SB that can be substantially modified by the prenatal environment. PMID:22473653

Rogers, Scott W; Tvrdik, Petr; Capecchi, Mario R; Gahring, Lorise C

2012-03-30

318

Promotor Genotype of the Platelet-derived Growth Factor Receptor-? gene Shows Population Stratification but Not Association with Spina Bifida Meningomyelocele  

PubMed Central

Neural tube defects (NTDs) constitute a major group of congenital malformations with an overall incidence of approximately 1 to 2 in 1000 live births in the United States. Hispanic Americans have a 2.5 times higher risk than the Caucasian population. Spina bifida meningomyelocele (SBMM) is a major clinical presentation of NTDs resulting from lack of closure of the spinal cord caudal to the head. In a previous study of spina bifida (SB) patients of European Caucasian descent, it was suggested that specific haplotypes of the platelet-derived growth factor receptor-? (PDGFRA) gene P1 promoter strongly affected the rate of NTD genesis. In our study, we evaluated the association of PDGFRA P1 in a group of 407 parent-child triads (167 Caucasian, 240 Hispanics) and 164 unrelated controls (89 Caucasian, 75 Hispanic). To fully evaluate the association of PDGFRA P1, we performed both transmission-disequilibrium test (TDT) and association analyses to test the hypotheses that PDGFRA P1 was (1) transmitted preferentially in SBMM affected children and (2) associated with the condition of SBMM comparing affected children to unaffected controls. We did find that there was a different allelic and genotypic distribution of PDGFRA P1 when comparing Hispanics and Caucasians. However, neither ethnic group showed strong association between SBMM and the PDGFRA P1 region. These findings suggest that PDGFRA P1 does not have a major role in the development of SBMM.

Au, K.-S.; Northrup, H; Kirkpatrick, TJ; Volcik, KA; Fletcher, JM; Townsend, IT; Blanton, SH; Tyerman, GH; Villarrea, G; King, TM

2008-01-01

319

Racial/Ethnic Differences in the Birth prevalence of Spina Bifida-United States, 1995-2005. Morbidity and Mortality Weekly Report, Vol. 57, No. 53, January 9, 2009.  

National Technical Information Service (NTIS)

In 1992, the U.S. Public Health Service recommended that all women of childbearing age consume 400 micro g of folic acid daily to help prevent pregnancies affected by neural tube defects (NTDs) such as spina bifida. Subsequently, the Food and Drug Adminis...

2009-01-01

320

Predictors of Parenting Behavior Trajectories Among Families of Young Adolescents with and without Spina Bifida  

Microsoft Academic Search

groups, findings were more robust for the SB sample. Among fathers of children with SB, parenting stress was positively associated with adaptive parenting at T1 but negatively associated with adaptive parenting change. In contrast, within the CG, paternal parenting stress was negatively associated with adaptive parenting at T1 but showed no enduring negative effects in longitudinal analyses. Conclusions Family conflict

Rachel Neff Greenley; Grayson N. Holmbeck; Brigid M. Rose

2006-01-01

321

Spina bifida cystica  

PubMed Central

There is an urgent need for criteria upon which to base the decision to close a myelomeningocoele soon after birth. Orthopaedic experience advises that early closure of the spinal lesion should not be done unless there is active flexion power at both hips. This criterion is offered with the knowledge that there may occasionally be other exceptional factors to contradict it, but it is based on experience of 96 personal cases aged between 18 months and 7 years. These cases are analysed and discussed. A further possible criterion for not closing the spinal lesion early is the presence of a gross lumbosacral kyphosis.

James, C. C. Michael

1971-01-01

322

The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy  

Microsoft Academic Search

Two major water-insoluble proteins are located on the surface of rubber particles in Hevea brasiliensis latex. A 14.6 kd protein (Hev b 1), found mainly on large rubber particles (>350 nm in diameter), and a 24 kd protein (Hev b 3), found mainly on small rubber particles (average diameter, 70 nm), are recognized by IgE from patients with spina bifida

Hoong Yeet Yeang; Kay Fong Cheong; Elumalai Sunderasan; Samsidar Hamzah; Nyu Ping Chew; Sharifah Hamid; Robert G. Hamilton; Mary Jane Cardosa

1996-01-01

323

Inadvertent positioning of suprapubic catheter in urethra: a serious complication during change of suprapubic cystostomy in a spina bifida patient - a case report  

PubMed Central

Introduction Spinal cord injury patients are at risk for developing unusual complications such as autonomic dysreflexia while changing suprapubic cystostomy. We report a male patient with spina bifida in whom the Foley catheter was placed in the urethra during change of suprapubic cystostomy with serious consequences. Case presentation A male patient, born in 1972 with spina bifida and paraplaegia, underwent suprapubic cystostomy in 2003 because of increasing problems with urethral catheter. The patient would come to spinal unit for change of suprapubic catheter every four to six weeks. Two days after a routine catheter change in November 2009, this patient woke up in the morning and noticed that the suprapubic catheter had come out. He went straight to Accident and Emergency. The suprapubic catheter was changed by a health professional and this patient was sent home. But the suprapubic catheter did not drain urine. This patient developed increasing degree of pain and swelling in suprapubic region. He did not pass any urine per urethra. He felt sick and came to spinal unit five hours later. About twenty ml of contrast was injected through suprapubic catheter and X-rays were taken. The suprapubic catheter was patent; the catheter was not blocked. The Foley catheter could be seen going around in a circular manner through the urinary bladder into the urethra. The contrast did not opacify urinary bladder; but proximal urethra was seen. The tip of Foley catheter was lying in proximal urethra. The balloon of Foley catheter had been inflated in urethra. When the balloon of Foley catheter was deflated, this patient developed massive bleeding per urethra. A sterile 22 French Foley catheter was inserted through suprapubic track. The catheter drained bloody urine. He was admitted to spinal unit and received intravenous fluids and meropenem. Haematuria subsided after 48 hours. The patient was discharged home a week later in a stable condition. Conclusion This case shows that serious complications can occur during change of suprapubic catheter in patients with neuropathic bladder. After inserting a new catheter, health professionals should observe spinal cord injury patients for at least thirty minutes and ensure that (1) suprapubic catheter drains clear urine; (2) patients do not develop abdominal spasm or discomfort; (3) symptoms and signs of sepsis or autonomic dysreflexia are absent.

2009-01-01

324

Functional Significance of Atypical Cortical Organization in Spina Bifida Myelomeningocele: Relations of Cortical Thickness and Gyrification with IQ and Fine Motor Dexterity.  

PubMed

The cortex in spina bifida myelomeningocele (SBM) is atypically organized, but it is not known how specific features of atypical cortical organization promote or disrupt cognitive and motor function. Relations of deviant cortical thickness and gyrification with IQ and fine motor dexterity were investigated in 64 individuals with SBM and 26 typically developing (TD) individuals, aged 8-28 years. Cortical thickness and 3D local gyrification index (LGI) were quantified from 33 cortical regions per hemisphere using FreeSurfer. Results replicated previous findings, showing regions of higher and lower cortical thickness and LGI in SBM relative to the TD comparison individuals. Cortical thickness and LGI were negatively associated in most cortical regions, though less consistently in the TD group. Whereas cortical thickness and LGI tended to be negatively associated with IQ and fine motor outcomes in regions that were thicker or more gyrified in SBM, associations tended to be positive in regions that were thinner or less gyrified in SBM. The more deviant the levels of cortical thickness and LGI-whether higher or lower relative to the TD group-the more impaired the IQ and fine motor outcomes, suggesting that these cortical atypicalities in SBM are functionally maladaptive, rather than adaptive. PMID:22875857

Treble, Amery; Juranek, Jenifer; Stuebing, Karla K; Dennis, Maureen; Fletcher, Jack M

2012-08-08

325

Use of Intravesicular Amikacin Irrigations for the Treatment and Prophylaxis of Urinary Tract Infections in a Patient with Spina Bifida and Neurogenic Bladder: A Case Report  

PubMed Central

This case report describes the use of intravesicular amikacin irrigations to treat and prevent urinary tract infections (UTIs) in a pediatric patient with spina bifida and neurogenic bladder. A 15 year old Hispanic female was admitted for a UTI caused by Enterobacter cloacae and multiple-drug resistant Pseudomonas aeruginosa. A 7 day course of daily intravenous amikacin and ceftazidime was initiated along with twice daily intravesicular amikacin irrigations (15 mg/30 mL) with a dwell time of 2 hours. The patient improved and was discharged on prophylactic Bactrim SS (sulfamethoxazole/trimethoprim) 1 tablet daily and intravesicular amikacin irrigations (15 mg/30 mL) once every other day. Approximately 2 months after discharge, the patient developed another UTI from multidrug resistant Escherichia coli and was treated with a 14 day course of daily intravenous ciprofloxacin accompanied by daily intravesicular amikacin irrigations. Adjunctive therapy with either once daily or twice daily intravesicular amikacin irrigations successfully treated the patient's UTI. However, prophylactic treatment with intravesicular amikacin failed to prevent future UTIs in this patient.

Huynh, Donna; Morgan, Jill A.

2011-01-01

326

Serial Neuropsychological Assessment and Evidence of Shunt Malfunction in Spina Bifida: A Longitudinal Case Study  

Microsoft Academic Search

Myelomeningocele is often accompanied by hydrocephalus (MMH), making it a potentially unstable neurological condition requiring shunt placement and possible revisions. Serial neuropsychological assessment is an important tool in monitoring children with MMH, as cognitive changes can indicate shunt malfunction and hydrocephalus. We present the case of a girl with MMH who had five neuropsychological assessments (ages 5, 7, 11, 12,

Melissa A. Matson; E. Mark Mahone; T. Andrew Zabel

2005-01-01

327

Complications of Benchekroun vesicostomy in a spina bifida patient: severe stenosis requiring permanent suprapubic cystostomy, recurrent vesical calculi and abdominal hernia containing ileocystoplasty - a case report  

PubMed Central

Introduction In female patients with neuropathic bladder, the urethra is closed permanently in order to avoid urine leak. Then Benchekroun hydraulic ileal valve is attached to urinary bladder, thus providing a continent stoma for performing intermittent catheterisations. Case presentation We present a female patient with spina bifida who underwent Benchekroun continent vesicostomy in 1993. This patient developed severe stenosis of Benchekroun stoma and stones in urinary bladder. Dilatation of stoma and vesicolithotomy were carried out in 1995. Vesical calculi recurred; suprapubic cystolithotomy was performed in 1999. In March 2000, catheterisation of stoma was not possible and emergency suprapubic cystostomy was done. In April 2000, endoscopy was attempted through Benchekroun stoma. It was not possible to insert ureterorenoscope beyond two inches. The track was completely blocked. In November 2001, X-ray of abdomen showed several vesical calculi; suprapubic cystolithotomy was performed. In March 2005, this patient developed pain in abdomen. X-ray of abdomen showed a large vesical calculus. In June 2005, suprapubic catheter was removed and a cystoscope was introduced in to the bladder. Then electrohydraulic lithotripsy was performed. In 2007, this patient was concerned about the increasing swelling in lower abdomen. Computed tomography of abdomen revealed midline, lower abdominal wall hernia, which contained several loops of small bowel and ileal cystoplasty. The large hernia was uncomfortable and tender on coughing, but did not cause obstructive bowel symptoms. Surgical repair of hernia was considered. But this patient would require alternative way of urinary diversion because the current location of suprapubic catheter would almost lead to infection of prosthetic material used in reconstruction of the anterior abdominal wall. After discussing risks of operative procedures with patient and her husband, it was decided not to proceed with surgery. Conclusion This case is a poignant reminder to spinal cord physicians that novel surgical techniques should be viewed cautiously, and patients should be informed of potential complications of surgical procedures some of which could be irreversible.

2009-01-01

328

Lumbosacral lipomas with spina bifida  

Microsoft Academic Search

The pathological and metabolic characteristics, as well as the anatomical and functional evolution of lumbosacral lipomas, were studied in a series of 73 patients operated on between 1970 and 1983. The pathological study showed that they are mainly composed of adipocytes, but that they also possess fibrous tissue, vessels, and nerve fibers. Innervated muscle fibers, contracting under proper nerve stimulation,

J. F. Hirsch; A. Pierre-Kahn

1988-01-01

329

Spina Bifida and Agent Orange  

MedlinePLUS

... Benefits Survivors' Benefits Exposure Locations » Overview Vietnam Blue Water Veterans Ships in Vietnam Korean Demilitarized Zone Thailand Military Bases Tests and Storage Residue on Planes Provider Resources Research Studies Publications & ...

330

Human tail with spina bifida.  

PubMed

A true human tail is a rare occurrence and is defined as a caudal, vestigial, midline protrusion with skin covering connective tissue, muscle, vessels and nerves. We report a case of true human tail in a child, which is a very rare happening in humans. PMID:19922280

Chauhan, S P S; Gopal, N N; Jain, Mohit; Gupta, Anurag

2009-12-01

331

Spina bifida and other neural tube defects  

Microsoft Academic Search

~ eural tube defects (NTDs) are the most common severely disabling birth defects in the United States, with a frequency of approximately 1 of every 2000 births. NTDs include all congenital anom- alies that involve failure of the neural tube to close during the fourth week of embryogenesis. NTDs can occur anywhere along the formation of the spinal cord, from

Kelly A. Volcik

2000-01-01

332

Natural Rubber Latex Allergy in Spina Bifida  

MedlinePLUS

... fruits and vegetables. Some of them include: banana, avocado, chestnut, kiwi, apple, carrot, celery, papaya, potato, tomato, melon, and avocado. Due to nutritional risks, people should not avoid ...

333

Myelomeningocele (open spina bifida) - surgical management.  

PubMed

Myelomeningocele has been recognized since ancient times although written descriptions began not before the 17th century. Among all serious congenital malformations, myelomeningocele is unique that is has a steady and considerable prevalence while being compatible with life. It has a dismal prognosis when left untreated where virtually all die within the first year while aggressive treatment have a profound effect on survival and quality of life. Effective surgical treatment became possible parallel to the treatment of hydrocephalus in the late 1950s. Advent of the shunt systems undoubtedly changed the morbidity and mortality rates due to associated hydrocephalus. Aggressive and effective treatment improved survival rates but also those suffering physical and mental disabilities have increased as well. Ethical and socioeconomic concerns have led to proposal for selective treatment criteria which have raised arguments on medical and ethico-legal rounds. After the swing of the pendulum between early treatment in all affected children and selective treatment of those who fulfilled the criteria for good prognosis, early myelomeningocele repair is practiced widely unless the infant is critically ill.Incidence of myelomeningocele has been decreasing especially in the Western world, partly due to prenatal diagnosis and elective terminations, dietary folate supplementation. Still, it is the most common central nervous system malformation and one of the leading causes of paraplegia, worldwide. Unfortunately, gains in the management of myelomeningocele have been mainly on antenatal diagnosis and prevention while efforts on understanding its cause, mechanisms involved are still tentative. Concerning the surgical management, no revolutionary modification improving outcome has been introduced unlike other fields of neurosurgery.Medical management of a child with myelomeningocele requires a lifelong effort of several disciplines including urology, orthopedics physical and social therapy besides neurosurgery. The initial and probably the most crucial step begin with proper repair of the lesion. The aim of surgery, with its simplest definition should be towards maintaining the medical condition of the newborn. In other words, consequences of an open spinal cord segment with associated malformations have to be avoided with appropriate measures. Comparable to the surgical treatment of any congenital malformation, myelomeningocele repair consist of reversing the failed steps of normal neural tube closure. This requires a thorough understanding of the normal and abnormal embryological sequence of events in formation of the spinal cord. Although the purpose of this chapter is to describe the basic concepts and technique of myelomeningocele repair, contemporary information and progress on epidemiology, and etiology and embryology is presented with discussion of controversial issues regarding the selection process, optimal time for surgery and technical modifications. PMID:21997743

Akalan, N

2011-01-01

334

76 FR 19995 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Funding...  

Federal Register 2010, 2011, 2012, 2013

...Review The meeting announced below concerns ``National Spina Bifida Registry Longitudinal Data Collection and Evaluation...of applications received in response to ``National Spina Bifida Registry Longitudinal Data Collection and...

2011-04-11

335

Occurrence of Split Cord Malformation in Meningomyelocele: Complex Spina bifida  

Microsoft Academic Search

Objective: To describe the clinical features and surgical outcome of a combined anomaly, i.e. split cord malformation (SCM) with meningomyelocele (MMC), and to propose an addition to Pang’s classification of SCM to accommodate a combined form of anomaly. Methods: We retrospectively analyzed 16 cases of such a combination, out of a total of 106 cases of spinal dysraphism treated and

Raj Kumar; Krishan Kumar Bansal; Devendra Kumar Chhabra

2002-01-01

336

Spina bifida occulta in isthmic spondylolisthesis: a surgical trap  

Microsoft Academic Search

An 11-year-old girl presented with symptomatic grade IIB isthmic type spondylolisthesis, with an elongated pars, confirmed on magnetic resonance imaging (MRI). Posterolateral in situ fusion of L5\\/S1 was performed. At surgery, a significant bony defect in the posterior aspect of S1 was noted. Awareness of this possible co-existence is paramount if iatrogenic damage to neural elements is to be avoided

R. Kumar; D. Niall; A. Walsh; K. Khalilullah; D. A. McCormack

2002-01-01

337

Frequency of Spina Bifida Occulta in Prehistoric Human Skeletons  

Microsoft Academic Search

IN a cave at Taforalt, in the Beni Znassen country of north-eastern Morocco not far from Oujda, the Abbé J. Roche excavated about 80 adult and more than 100 infantile skeletons of the Mechta-Afalou type, associated with an Ibero-Maurusian industry (Epipalæolithic). These remains give a carbon-14 date of 10,500-12,070 years according to the layers.

Denise Ferembach

1963-01-01

338

What Are the Treatments for Spina Bifida and Related Conditions?  

MedlinePLUS

... they may use braces, crutches, walkers, or wheelchairs. Urinary Tract Infections, Lack of Bladder and Bowel Control People with ... from completely emptying, a condition that can cause urinary tract infections and kidney damage. The child or parent can ...

339

The Role of Fetal Neurosurgery in Spina Bifida  

Microsoft Academic Search

Myelomeningocele (MMC) is a nonlethal form of neural tube defect (NTD) that results from failure of the neural tube to fuse\\u000a during early embryogenesis. The lesion is characterized by protrusion of the meninges through a midline bony defect of the\\u000a spine, a sac containing cerebrospinal fluid and dysplastic neural tissue not covered by skin. MMC represents an important\\u000a congenital defect

Sergio Cavalheiro; Wagner J. Hisaba; Antonio F. Moron; Carlos G. Almodin

340

Spina bifida occulta in isthmic spondylolisthesis: a surgical trap.  

PubMed

An 11-year-old girl presented with symptomatic grade IIB isthmic type spondylolisthesis, with an elongated pars, confirmed on magnetic resonance imaging (MRI). Posterolateral in situ fusion of L5/S1 was performed. At surgery, a significant bony defect in the posterior aspect of S1 was noted. Awareness of this possible co-existence is paramount if iatrogenic damage to neural elements is to be avoided during surgery. PMID:11956923

Kumar, R; Niall, D; Walsh, A; Khalilullah, K; McCormack, D

2001-12-14

341

Surgery on Fetus Reduces Complications of Spina Bifida  

MedlinePLUS Videos and Cool Tools

... an opening in the spine. In a new Web video, study author Catherine Y. Spong, M.D., ... medical rehabilitation. For more information, visit the Institute’s Web site at http://www.nichd.nih.gov/ . The ...

342

Ophthalmologic complications of meningomyelocele: a longitudinal study.  

PubMed Central

Patients with spina bifida have multiple ophthalmologic problems, many of which are preventable. Most of the problems are related to the hydrocephalus, which is caused by the coexisting Arnold-Chiari malformation. When patients are treated for hydrocephalus, and comprehensive eye care is available, 94% of the patients will have 6/12 visual acuity or better. Strabismus is common but it responds well to medical and surgical treatment. Children with spina bifida should have frequent examinations by an ophthalmologist who is familiar with the diagnosis and management of the defects recorded in this study. Images FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12

Biglan, A W

1990-01-01

343

Ethnic differences in the prevalence of anencephaly and sina bifida in Boston, Massachusetts.  

PubMed

because of the large Irish population, a group with high prevalence rates of anencephaly and spina bifida, and the small Jewish population, a group with very low prevalences of these anomalies, cases of anencephaly and spina bifida born in 1 of 4 Boston maternity hospitals were compared with a systematic 1 in 300 sample of all births in the same facilities. Estimates of prevalence were made according to ethnic group, socioeconomic status, and parity. As expected, Irish offspring showed high rates (3.1 per 1000 births) of prevalence for these congenital defects, and these rates did not change in degree if the investigation was restricted to mother only, father only, or both parents Irish heritage. If mothers were born in Ireland, however, the prevalence rate was 4.9/1000. Offspring of Jewish mothers had the lowest rates of any ethnic group examined (Protestant, Irish Catholic, Roman Catholic, and other religions), .77/1000. However, in the highest economic classes, differences between the 3 major religions were not significant. Other ancestories showed the following prevalences: Italian, 1.09; Canadian, 3.18; English, 1.49; and other U.S., 2.58. Overall in Massachusetts the rate was 3.11. Prevalence rates increased dramatically with increasing socioeconomic status. Association with parity was also noticed; parity and ehtnic group were independent associations, as were ethnic and socioeconomic class. PMID:4861562

Naggan, L; MacMahon, B

1967-11-23

344

Is the Vertebral Expandable Prosthetic Titanium Rib a Surgical Alternative in Patients with Spina Bifida?  

Microsoft Academic Search

Background  Nonambulatory children with myelodysplasia are most likely to develop spinal deformity. As the deformity progresses, the overall\\u000a health of the patient deteriorates. Traditional management of the deformity with fusion results in a short trunk, crankshaft\\u000a deformity, and spine and lung growth inhibition. One alternative that potentially minimizes these problems is the vertebral\\u000a expandable prosthetic titanium rib (VEPTR).\\u000a \\u000a \\u000a \\u000a \\u000a Questions\\/purposes  We therefore asked

John M. Flynn; Norman Ramirez; John B. Emans; John T. Smith; Mary Jane Mulcahey; Randal R. Betz

2011-01-01

345

Association between CFL1 gene polymorphisms and spina bifida risk in a California population  

Microsoft Academic Search

BACKGROUND: CFL1 encodes human non-muscle cofilin (n-cofilin), which is an actin-depolymerizing factor and is essential in cytokinesis, endocytosis, and in the development of all embryonic tissues. Cfl1 knockout mice exhibit failure of neural tube closure at E10.5 and die in utero. We hypothesized that genetic variation within the human CFL1 gene may alter the protein's function and result in defective

Huiping Zhu; James O Ebot Enaw; Chen Ma; Gary M Shaw; Edward J Lammer; Richard H Finnell

2007-01-01

346

Spina bifida with associated malformations of the central nervous system in Dorper-cross sheep  

Microsoft Academic Search

CASE HISTORY: In 2008, six lambs within a flock of Dorpercross sheep were born with musculoskeletal and neurological disease. Clinical signs included hindlimb weakness, and urinary incontinence.CLINICAL FINDINGS: All lambs had focal, inverted areas of alopecic skin over the caudal sacrum, and short, often kinked tails. Four affected lambs were subject to euthanasia, and necropsied. On gross examination, the arches

KA Potter; JF Weston; JS Munday; AC Johnstone

2010-01-01

347

Characteristics of a spina bifida population including North American Caucasian and Hispanic individuals  

Microsoft Academic Search

BACKGROUND: Meningomyelocele (MM) is a common human birth defect. MM is a disorder of neural development caused by contributions from genes and environmental factors that result in the NTD and lead to a spectrum of physical and neurocognitive phenotypes.\\u000aMETHODS: A multidisciplinary approach has been taken to develop a comprehensive understanding of MM through collaborative efforts from investigators specializing in

Kit Sing Au; Phong X. Tran; Chester C. Tsai; Michelle R OByrne; Jone-Ing Lin; Alanna C. Morrison; Amy W. Hampson; Paul Cirino; Jack M. Fletcher; Kathryn K. Ostermaier; Gayle H. Tyerman; Sabine Doebel; Hope Northrup

2008-01-01

348

Parent and Self-Ratings of Executive Functions in Adolescents and Young Adults With Spina Bifida  

Microsoft Academic Search

This study examined the agreement and consistency of parent- and self-report of executive functioning (EF) (Behavior Rating Inventory of Executive Functions; BRIEF) in an adolescent cohort of youth with myelomeningocele and shunted hydrocephalus (MMH). A total of 30 youth participants with MMH and their parents were recruited during adolescence (age 11–18, mean age 14), and a smaller sample (n?=?13) was

T. Andrew Zabel; Lisa A. Jacobson; Claire Zachik; Eric Levey; Stephen Kinsman; E. Mark Mahone

2011-01-01

349

Pseudo-tumours of the urinary tract in patients with spinal cord injury\\/spina bifida  

Microsoft Academic Search

Objective: To raise awareness of pseudo-tumours of urinary tract, as pseudo-tumours represent benign mass lesions simulating malignant neoplasms. Accurate diagnosis helps to avoid unnecessary surgery in spinal cord injury patients.Setting: Regional Spinal Injuries Centre, Southport, UKCase reports:Pseudo-tumour of kidney: A 58-year-old man with tetraplegia developed a right perirenal haematoma while taking warfarin; ultrasound and CT scanning showed no evidence of

S Vaidyanathan; P L Hughes; P Mansour; B M Soni; Gurpreet Singh; J W H Watt; T Oo; P Sett

2004-01-01

350

Optimism, appraisals, and coping in the adjustment of mothers and their children with spina bifida  

Microsoft Academic Search

Families of children with physical disabilities show substantial differences in the levels of adjustment of both the children and their parents. These differences result, in part, from the complex interplay of family and child adaptation resources, such as coping and social support. In order to identify factors which may differentiate levels of adjustment among families with children with physical disabilities,

Lamia P. Barakat; Jean Ann Linney

1995-01-01

351

A Family-Centered Evaluation of Psychosocial Agendas in Spina Bifida  

Microsoft Academic Search

Care patterns and parenting quality have an important effect on the infant-caregiver relationship, as well as on the developmental\\u000a outcomes of children [1]. High quality care is linked to higher cognitive ability and higher social competence in children [2]. Especially in the case of disability, families and other close networks gain a pivotal role as the main caregivers for\\u000a the

Mehmet Kemal Ku?cu; Banu Cankaya

352

JUMONJI GENE AND RISK FOR SPINA BIFIDA AND CONGENITAL HEART DEFECTS. (R828292)  

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

353

ASSOCIATIONS BETWEEN POLYMORPHISMS WITHIN THE THYMIDYLATE SYNTHASE GENE AND SPINA BIFIDA. (R828292)  

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

354

Tetraploidy in a liveborn infant with spina bifida and other anomalies  

Microsoft Academic Search

Although tetraploidy of human chromosomes (92,XXYY) has been described frequently in abortuses, only one example in a liveborn infant has previously been described. A second malformed infant with a complete tetraploid chromosome complement, who lived for 15 days, is reported. In addition to many of the malformations described in the first case, this infant also had a sacral myelomeningocele and

D Pitt; M Leversha; C Sinfield; P Campbell; R Anderson; D Bryan; J Rogers

1981-01-01

355

Maternal Vitamin Use, Genetic Variation of Infant Methylenetetrahydrofolate Reductase, and Risk for Spina Bifida  

Microsoft Academic Search

Maternal periconceptional use of vitamin supplements containing folic acid substantially reduces the risk of neural tube defects (NTDs) in the offspring. The mechanism underlying this reduction in risk is unknown. Several recent studies have reported an association between homozygosity for a variant form (the C677T genotype) of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and risk for NTDs in individuals. It has

Gary M. Shaw; Rima Rozen; Richard H. Finnell; Cathy R. Wasserman; Edward J. Lammer

356

Arithmetic Achievement in Children with Cerebral Palsy or Spina Bifida Meningomyelocele  

ERIC Educational Resources Information Center

The aim of this study was to establish whether children with a physical disability resulting from central nervous system disorders (CNSd) show a level of arithmetic achievement lower than that of non-CNSd children and whether this is related to poor automaticity of number facts or reduced arithmetic instruction time. Twenty-two children with CNSd…

Jenks, Kathleen M.; van Lieshout, Ernest C. D. M.; de Moor, Jan

2009-01-01

357

Valproic acid sodium-induced spina bifida occulta in the rat  

Microsoft Academic Search

The antiepileptic drug valproic acid is a well-known teratogenic agent; its main target organ is the neuroepithelium neural\\u000a tube, although skeletal malformations have also been described. The goal of our investigations was to determine whether there\\u000a is a direct relationship between high doses of valproic acid and vertebral arch openings. On day 9 of gestation, rats were\\u000a treated with either

Süreyya Ceylan; Soner Duru; Savas Ceylan

2001-01-01

358

A Case of Meningomyelocele in a Kindred with Multiple Cases of Spondylolisthesis and Spina Bifida Occulta  

Microsoft Academic Search

A child with meningomyelocele, and other spinal anomalies, was born to a woman with three sibs who had spondylolisthesis and whose father and two of his sibs had a history of back problems. The suggestion is made that these anomalies represent a pattern of autosomal dominant inheritance with variable expressivity.

Lowell E. Sever

1974-01-01

359

The current management of the neurogenic bladder in children with spina bifida.  

PubMed

The urological care of the neurogenic bladder consists of 2 components: medical management with preservation of renal function and quality-oflife issues with achieving dryness and independence of bladder and bowel management. Both components are equally important for patients to live a healthy and fulfilled life. This report explores the diagnosis of the neurogenic bladder; quality-of-life issues that caregivers and patients should expect; the importance of primary care knowledge of the neurogenic bladder and treatment; surgical options; the transition of pediatric patients to adult care; and the importance of caregiver and patient understanding of their disease, treatment options, and responsibilities. PMID:22857827

Frimberger, Dominic; Cheng, Earl; Kropp, Bradley P

2012-06-22

360

Deliberate termination of life of newborns with spina bifida, a critical reappraisal  

PubMed Central

Objects Deliberate termination of life of newborns (involuntary euthanasia) with meningomyelocele (MMC) is practiced openly only in the Netherlands. ‘Unbearable and hopeless suffering’ is the single most cited criterion for this termination, together with the notion that ‘there are no other proper medical means to alleviate this suffering’. In this paper, both (and other) statements are questioned, also by putting them in a broader perspective. Methods First, a historical overview of the treatment of newborns with MMC is presented, concentrating on the question of selection for treatment. Second, a thorough analysis is made of the criteria used for life termination. Third, a case of a newborn with a very severe MMC is presented as a ‘reference case’. Conclusion ‘Unbearable and hopeless suffering’ cannot be applied to newborns with MMC. They are not ‘terminally ill’ and do have ‘prospects of a future’. In these end-of-life decisions, ‘quality of life judgments’ should not be applied. When such a newborn is not treated, modern palliative care always will suffice in eliminating possible discomfort. There is no reason whatsoever for active life-termination of these newborns.

2007-01-01

361

Fetal Spina Bifida Repair – Current Trends and Prospects of Intrauterine Neurosurgery  

Microsoft Academic Search

Myelomeningocele is a common dysraphic defect leading to severe impairment throughout the patient’s lifetime. Although surgical closure of this anomaly is usually performed in the early postnatal period, an estimated 330 cases of intrauterine repair have been performed in a few specialized centers worldwide. It was hoped prenatal intervention would improve the prognosis of affected patients, and preliminary findings suggest

M. A. Fichter; U. Dornseifer; J. Henke; K. T. M. Schneider; L. Kovacs; E. Biemer; J. Bruner; N. S. Adzick; M. R. Harrison; N. A. Papadopulos

2008-01-01

362

Characteristics of a Spina Bifida Population Including North American Caucasian and Hispanic Individuals  

PubMed Central

BACKGROUND Meningomyelocele (MM) is a common human birth defect. MM is a disorder of neural development caused by contributions from genes and environmental factors that result in the neural tube defect and lead to a spectrum of physical and neurocognitive phenotypes. METHODS A multi-disciplinary approach has been taken to develop a comprehensive understanding of MM through collaborative efforts from investigators specializing in genetics, development, brain imaging, and neurocognitive outcome. Patients have been recruited from five different sites: Houston and the Texas-Mexico border area; Toronto, Canada; Los Angeles, California; and Lexington, Kentucky. Genetic risk factors for MM have been assessed by genotyping and association testing using the transmission disequilibrium test. RESULTS A total of 509 affected child/parent trios and 309 affected child/parent duos have been enrolled to date for genetic association studies. Subsets of the patients have also been enrolled for studies assessing development, brain imaging, and neurocognitive outcomes. The study recruited two major ethnic groups with 45.9% Hispanics of Mexican descent and 36.2% North American Caucasians of European descent. The remaining patients are African American, South and Central American, Native American and Asian. Studies of this group of patients have already discovered distinct corpus callosum morphology and neurocognitive deficits that associate with MM. We have identified maternal MTHFR 667T allele as a risk factor for MM. In addition, we also found that several genes for glucose transport and metabolism are potential risk factors for MM. CONCLUSIONS The enrolled patient population provides a valuable resource for elucidating the disease characteristics and mechanisms for MM development.

Au, Kit Sing; Tran, Phong X.; Tsai, Chester C.; O'Byrne, Michelle R.; Lin, Jone-Ing; Morrison, Alanna C.; Hampson, Amy W.; Cirino, Paul; Fletcher, Jack M.; Ostermaier, Kathryn K.; Tyerman, Gayle H.; Doebel, Sabine; Northrup, Hope

2008-01-01

363

Change in spinal curvature following release of tethered spinal cord associated with spina bifida.  

PubMed

Changes in spinal curvature, scoliosis, kyphosis and lordosis are associated with the growth of patients with myelomeningocele. Previous investigators have stated that progressive developmental scoliosis is related to tethered spinal cord. In order to investigate the relationship of tethered spinal cord release to progression of spinal curvature, we surveyed the medical records of 262 patients with a history of one or more tethered spinal cord release. For 216 of these patients, a total of 2,369 serial spine x-rays, obtained over a 20-year period, were reviewed by the standard Cobb method for progression of scoliosis, thoracic kyphosis and lordosis. In addition, the serial spine x-rays of 74 patients without clinical findings of tethered spinal cord were collected and reviewed for comparison of progressive scoliosis and kyphosis. One hundred and sixty normal lumbar x-rays were evaluated to compare the progression of the lordotic curve in patients with tethered cord release with a normal population. Progression of scoliosis plateaued or declined following release of tethered cord in patients with lumbar and sacral level lesions, however, tether release did not halt the progression of scoliosis in the thoracic level group. Tethered cord release altered the course of lordosis in L1 through L3 level lesions, but had little affect on the normal progression of lordosis in patients with L4, L5 or sacral level lesions. Finally, tethered spinal cord release appears to be associated with a decrease in the incidence and magnitude of kyphosis. PMID:8142280

Reigel, D H; Tchernoukha, K; Bazmi, B; Kortyna, R; Rotenstein, D

1994-01-01

364

[Mature lumbar multi-tissue dysembryoma of the spinal cord with sacral spina bifida occulta].  

PubMed

The authors report the case of a 28-year-old woman who presented with L5 bilateral sciatica associated with perineal sensory disorders. During surgery, a mature pluritissular dysembryoma originating in a tethered spinal cord was discovered at the level of the L2-L3 intervertebral space. Following removal of the lesion, all symptoms disappeared. Mature pluritissular dysembryomas of the spinal cord result from the inclusion of neuroectodermal and mesodermal tissue which has not followed normal evolutive embryonic organization. PMID:2234262

Borne, G; Cristino, G; Bedou, G; Schaefer, J P; Pinaudeau, M

1990-01-01

365

Curly tail: a 50-year history of the mouse spina bifida model  

Microsoft Academic Search

This paper reviews 50 years of progress towards understanding the aetiology and pathogenesis of neural tube defects (NTD) in the curly tail (ct) mutant mouse. More than 45 papers have been published on various aspects of curly tail with the result that it is now the best understood mouse model of NTD pathogenesis. The failure of closure of the spinal

H. W. M. van Straaten; Andrew J. Copp

2001-01-01

366

38 CFR 21.8010 - Definitions and abbreviations.  

Code of Federal Regulations, 2010 CFR

...Certain Children of Vietnam Veterans-Spina Bifida and Covered Birth Defects General...of this title who suffers from spina bifida, or an individual as defined...program under this subpart. Spina bifida means the same as defined...

2010-07-01

367

38 CFR 17.900 - Definitions.  

Code of Federal Regulations, 2010 CFR

...Certain Children of Vietnam Veterans-Spina Bifida and Covered Birth Defects § 17...certificate. Child for purposes of spina bifida means the same as individual ...residing in such private residence. Spina bifida means all forms and...

2009-07-01

368

38 CFR 17.900 - Definitions.  

Code of Federal Regulations, 2010 CFR

...Certain Children of Vietnam Veterans-Spina Bifida and Covered Birth Defects § 17...certificate. Child for purposes of spina bifida means the same as individual ...residing in such private residence. Spina bifida means all forms and...

2010-07-01

369

Idiom Comprehension Deficits in Relation to Corpus Callosum Agenesis and Hypoplasia in Children with Spina Bifida Meningomyelocele  

ERIC Educational Resources Information Center

Idioms are phrases with figurative meanings that are not directly derived from the literal meanings of the words in the phrase. Idiom comprehension varies with: literality, whether the idiom is literally plausible; compositionality, whether individual words contribute to a figurative meaning; and contextual bias. We studied idiom comprehension in…

Huber-Okrainec, J.; Blaser, S.E.; Dennis, M.

2005-01-01

370

Decreased methylene tetrahydrofolate reductase activity due to the 677C?T mutation in families with spina bifida offspring  

Microsoft Academic Search

Periconceptional folate intake reduces both the occurrence and recurrence risk of neural tube defects. Plasma homocysteine\\u000a levels can be elevated in mothers of a child with a neural tube defect, suggesting a dysfunctional folate metabolism. Very\\u000a recently we showed that a common 677C?T mutation in the 5,10-methylene tetrahydrofolate reductase gene, causing thermolability\\u000a of the enzyme, is a risk factor for

N. M. J. van der Put; L. P. van den Heuvel; R. P. M. Steegers-Theunissen; F. J. M. Trijbels; T. K. A. B. Eskes; E. C. M. Mariman; M. den Heyer; H. J. Blom

1996-01-01

371

A Common Variant in Methionine Synthase Reductase Combined with Low Cobalamin (Vitamin B 12) Increases Risk for Spina Bifida  

Microsoft Academic Search

Impairment of folate and cobalamin (vitamin B12) metabolism has been observed in families with neural tube defects (NTDs). Genetic variants of enzymes in the homocysteine remethylation pathway might act as predisposing factors contributing to NTD risk. The first polymorphism linked to increased NTD risk was the 677C?T mutation in methylenetetrahydrofolate reductase (MTHFR). We now report a polymorphism in methionine synthase

Aaron Wilson; Robert Platt; Qing Wu; Daniel Leclerc; Benedicte Christensen; Hong Yang; Roy A. Gravel; Rima Rozen

1999-01-01

372

The Many Layers of Social Support: Capturing the Voices of Young People with Spina Bifida and Their Parents  

ERIC Educational Resources Information Center

Young people with physical disabilities experience greater difficulty than their able-bodied peers in many psychosocial domains as they transition toward adulthood. However, firsthand knowledge of the dimensions of social support that young people with physical disabilities find useful during this stage is lacking. This qualitative study involved…

Antle, Beverley J.; Montgomery, Gert; Stapleford, Christine

2009-01-01

373

RISK FACTORS FOR NEURAL TUBE DEFECTS: ASSOCIATIONS BETWEEN UNCOUPLING PROTEIN 2 POLYMORPHISMS AND SPINA BIFIDA. (R828292)  

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

374

EVALUATION OF THE CITED2 GENE AND RISK FOR SPINA BIFIDA AND CONGENITAL HEART DEFECTS. (R828292)  

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

375

Prenatal Diagnosis and Genetic Counseling in a Case of Spina Bifida in a Family with Waardenburg Syndrome Type I  

Microsoft Academic Search

Objective: Waardenburg syndrome type I (WS I) is an autosomal dominant inherited disorder with an incidence of 1:45,000 in Europe. Mutations within the PAX3 gene are responsible for the clinical phenotype ranging from mild facial features to severe malformations detectable in prenatal diagnosis. Methods: Here, we report a four-generation family with several affected members showing various symptoms of WS I.

Annegret Kujat; Veit-Peter Veith; Renaldo Faber; Ursula G. Froster

2007-01-01

376

Age-related Differences in Executive Function Among Children with Spina Bifida\\/Hydrocephalus Based on Parent Behavior Ratings  

Microsoft Academic Search

Previous research has suggested that adolescents with myelomeningocele and shunted hydrocephalus (MMH) have difficulties with aspects of executive functioning and, in turn, with functional independence. There is little research, however, examining patterns of executive functioning across adolescence in this population. The goal of this cross-sectional study was to examine parent ratings of executive function in children with MMH and in

Reem A. Tarazi; T. Andrew Zabel; E. Mark Mahone

2008-01-01

377

Low Temperature Mitigates Cardia Bifida in Zebrafish Embryos  

PubMed Central

The coordinated migration of bilateral cardiomyocytes and the formation of the cardiac cone are essential for heart tube formation. We investigated gene regulatory mechanisms involved in myocardial migration, and regulation of the timing of cardiac cone formation in zebrafish embryos. Through screening of zebrafish treated with ethylnitrosourea, we isolated a mutant with a hypomorphic allele of mil (s1pr2)/edg5, called s1pr2as10 (as10). Mutant embryos with this allele expressed less mil/edg5 mRNA and exhibited cardia bifida prior to 28 hours post-fertilization. Although the bilateral hearts of the mutants gradually fused together, the resulting formation of two atria and one tightly-packed ventricle failed to support normal blood circulation. Interestingly, cardia bifida of s1pr2as10 embryos could be rescued and normal circulation could be restored by incubating the embryos at low temperature (22.5°C). Rescue was also observed in gata5 and bon cardia bifida morphants raised at 22.5°C. The use of DNA microarrays, digital gene expression analyses, loss-of-function, as well as mRNA and protein rescue experiments, revealed that low temperature mitigates cardia bifida by regulating the expression of genes encoding components of the extracellular matrix (fibronectin 1, tenascin-c, tenascin-w). Furthermore, the addition of N-acetyl cysteine (NAC), a reactive oxygen species (ROS) scavenger, significantly decreased the effect of low temperature on mitigating cardia bifida in s1pr2as10 embryos. Our study reveals that temperature coordinates the development of the heart tube and somitogenesis, and that extracellular matrix genes (fibronectin 1, tenascin-c and tenascin-w) are involved.

Lin, Che-Yi; Huang, Cheng-Chen; Wang, Wen-Der; Hsiao, Chung-Der; Cheng, Ching-Feng; Wu, Yi-Ting; Lu, Yu-Fen; Hwang, Sheng-Ping L.

2013-01-01

378

A Rare Case of Chondromyxoid Fibroma Mimicking Spina Ventosa  

PubMed Central

Chondromyxoid fibroma (CMF) is perhaps the rarest of all bone tumors. Classically it occurs in the metaphyseal region of the long bones surrounding the knee. The small bones of the feet are also commonly involved. But CMF occurring in small bones of the hand, however, is very uncommon. Tuberculous dactylitis is referred to as spina ventosa. The bones of the hands are more frequently affected than bones of the feet. We present a rare case of CMF occurring in the middle phalanx of the left middle finger which was misdiagnosed as spina ventosa clinicoradiologically. It can be a common mistake especially in areas where prevalence of tuberculosis is still high. This case once again stresses the need for biopsy and to consider CMF as a rare differential diagnosis in all suspected cases of spina ventosa.

Khan, Kalyan; Bandyopadhyay, Arghya

2012-01-01

379

Spectral analysis of erector spinae EMG during intermittent isometric fatiguing exercise  

Microsoft Academic Search

The applicability of EMG spectral analysis in the study of muscular fatigue of the erector spinae muscle was investigated. At three locations (L1, L2, L5) of the erector spinae muscle, representing different functional parts, EMG was sampled during fatiguing intermittent isometric extension of the trunk. The multifidus muscle (L5) appeared to show the most consistent changes of the EMG power

J. H. VAN DIEEN; H. M. TOUSSAINT; C. THISSEN; A. VAN DE VEN

1993-01-01

380

Structural properties of the tubular appendage spinae from marine bacterium Roseobacter sp. strain YSCB  

PubMed Central

Spinae are tubular surface appendages broadly found in Gram-negative bacteria. Little is known about their architecture, function or origin. Here, we report structural characterization of the spinae from marine bacteria Roseobacter sp. YSCB. Electron cryo-tomography revealed that a single filament winds into a hollow flared base with progressive change to a cylinder. Proteinase K unwound the spinae into proteolysis-resistant filaments. Thermal treatment ripped the spinae into ribbons that were melted with prolonged heating. Circular dichroism spectroscopy revealed a dominant beta-structure of the spinae. Differential scanning calorimetry analyses showed three endothermic transformations at 50–85°C, 98°C and 123°C, respectively. The heating almost completely disintegrated the spinae, abolished the 98°C transition and destroyed the beta-structure. Infrared spectroscopy identified the amide I spectrum maximum at a position similar to that of amyloid fibrils. Therefore, the spinae distinguish from other bacterial appendages, e.g. flagella and stalks, in both the structure and mechanism of assembly.

Bernadac, A.; Wu, L.-F.; Santini, C.-L.; Vidaud, C.; Sturgis, J. N.; Menguy, N.; Bergam, P.; Nicoletti, C.; Xiao, T.

2012-01-01

381

38 CFR 3.814 - Monetary allowance under 38 U.S.C. chapter 18 for an individual suffering from spina bifida whose...  

Code of Federal Regulations, 2013 CFR

...or marital status, whose biological father or mother is or was...the Vietnam era, or whose biological father or mother is or was...Secretary that a person is the biological son or daughter of a Vietnam...medication or other means to control incontinence. (ii)...

2013-07-01

382

Effects of age and gender on the frequencies of spondylolysis and spina bifida occulta in a skeletal collection from Golovin Bay, Alaska  

Microsoft Academic Search

It has been suggested that the occurrence of spondylolysis is dependent on both gender and age. This study determined the frequency of spondylolysis in a skeletal population from Golovin Bay, AK in relation to gender and age differences. Spondylolysis was characterized only in individuals with complete lumbar regions (n=52). The overall frequency for this population is 46.9%. No statistical differences

Scott S Legge

2000-01-01

383

Does a Myelomeningocele Sac Compared to No Sac Result in Decreased Postnatal Leg Function following Maternal Fetal Surgery for Spina Bifida Aperta?  

Microsoft Academic Search

Objective: A fetus with large sac S1 myelomeningocele (MMC) but bilateral talipes prompted the question, ‘Does the presence or size of an MMC sac affect postnatal leg function?’ Study Design: An MMC database with prenatal, birth, and a minimum of 1-year follow-up evaluation was reviewed. All fetuses had in-utero MMC repair at 20 + 0 to 25 + 6 weeks

R. Douglas Wilson; Mark P. Johnson; Michael Bebbington; Alan W. Flake; Holly L. Hedrick; Leslie N. Sutton; N. Scott Adzick

2007-01-01

384

Applications of Individual Growth Curve Modeling for Pediatric Psychology Research  

Microsoft Academic Search

Objective To provide a brief, nontechnical introduction to individual growth curve modeling for the analysis of longitudinal data. Several applications of individual growth curve modeling for pediatric psychology research are discussed. Methods To illustrate these applications, we analyze data from an ongoing pediatric psychology study of the possible impact of spina bifida on child and family development (N = 135).

Christian DeLucia; Steven C. Pitts

2006-01-01

385

75 FR 9276 - Proposed Information Collection (Application for CHAMPVA Benefits); Comment Request  

Federal Register 2010, 2011, 2012, 2013

...veterans born with spina bifida and certain other covered birth defects. DATES: Written comments and recommendations on the...expenses related to spina bifida and certain covered birth defects. Affected Public: Individuals or households....

2010-03-01

386

76 FR 9578 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): National...  

Federal Register 2010, 2011, 2012, 2013

...and Control Special Emphasis Panel (SEP): National Spina Bifida Patient Registry--Clinic Demonstration Project...review, discussion, and evaluation of the ``National Spina Bifida Patient Registry--Clinic Demonstration...

2011-02-18

387

38 CFR 17.903 - Payment.  

Code of Federal Regulations, 2013 CFR

...Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects § 17.903 Payment...payment, the services must have occurred: (i) For spina bifida, on or after October 1, 1997, and must have...

2013-07-01

388

76 FR 58567 - Proposed Information Collection (Request for Transportation Expense Reimbursement) Activity...  

Federal Register 2010, 2011, 2012, 2013

...on the information needed to determine children with spina bifida eligibility for reimbursement of transportation expenses...Abstract: Children of Vietnam veterans born with spina bifida and receiving vocational training or seeking...

2011-09-21

389

38 CFR 17.902 - Preauthorization.  

Code of Federal Regulations, 2013 CFR

...Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects § 17.902 Preauthorization...automobiles). Authorization will only be given in spina bifida cases where there is a demonstrated medical...

2013-07-01

390

Sacral Dimple  

MedlinePLUS

... A very mild form of this condition, called spina bifida occulta, occurs when the spine doesn't close properly ... remains within the spinal canal. In most cases, spina bifida occulta causes no symptoms. Tethered cord syndrome. The spinal ...

391

38 CFR 3.403 - Children.  

Code of Federal Regulations, 2013 CFR

...for an individual suffering from spina bifida who is a child of a Vietnam veteran...for an individual suffering from spina bifida who is a child of a Vietnam...for an individual suffering from spina bifida who is a child of a veteran...

2013-07-01

392

Functional morphology of the podia and ambulacral grooves of the comatulid crinoid Antedon bifida (Echinodermata)  

Microsoft Academic Search

Feeding units — viz. triplets of unequally-sized podia associated with protective lappets — occur all along the pinnules of adult Antedon bifida (Pennant). Small food particles are trapped by direct mucus impingement to the wall of primary and secondary podia (there are no mucus net or mucus thread helping in this process). Large particles are caught by primary and secondary

M. C. Lahaye; M. Jangoux

1985-01-01

393

The skeleton of the stalked stages of the comatulid crinoid Antedon bifida (Echinodermata)  

Microsoft Academic Search

The cystidean calyx of Antedon bifida (Pennant, 1777) consists of two superposed series of five inter-radially located plates called basals (lower plates) and orals (upper plates). A single radianal and five radial plates develop in early pentacrinoids. They are radially located between the orals and the basals and alternate with them. During pentacrinoid life, radials grow continuously while orals progressively

Marie-Christine Lahaye; Michel Jangoux

1987-01-01

394

Relationship Between Erectores Spinae Voltage and Back-Lift Strength for Isometric, Concentric, and Eccentric Contractions  

ERIC Educational Resources Information Center

This study determined the maximal mean values for concentric and eccentric back-lift strength as well as isometric, and examined and compared the relationships between the mean peak voltage of the erectores spinae muscle(s) and maximal force exerted for the three types of muscle contractions. (RC)

Ashton, T. Edwin J.; Singh, Mohan

1975-01-01

395

The ethnobotany of Christ's Thorn Jujube (Ziziphus spina-christi) in Israel  

Microsoft Academic Search

This article surveys the ethnobotany of Ziziphus spina-christi (L.) Desf. in the Middle East from various aspects: historical, religious, philological, literary, linguistic, as well as pharmacological, among Muslims, Jews, and Christians. It is suggested that this is the only tree species considered \\

Amots Dafni; Shay Levy; Efraim Lev

2005-01-01

396

Examination of the flexion relaxation phenomenon in erector spinae muscles during short duration slumped sitting  

Microsoft Academic Search

Objective. The purpose of this study was to examine the myoelectric activity of the erector spinae muscles of the back in order to determine if the flexion relaxation phenomenon occurs in seated forward flexion or slumped postures.Background. The flexion relaxation phenomenon during standing forward flexion is well documented. However, flexion relaxation in seated forward flexion has not been studied. It

Jack P Callaghan; Nadine M Dunk

2002-01-01

397

Quantification of erector spinae muscle fatigue during prolonged, dynamic lifting tasks  

Microsoft Academic Search

A method was developed to quantify erector spinae fatigue resulting from repetitive dynamic lifting in the sagittal plane. This method was tested with the data from eight male subjects lifting inertial loads of 19 kg and 17 kg during sessions of 20 min and 2 h, respectively. Surface EMG electrodes were applied over sites representing the bilateral lumbar and thoracic

J. R. Potvin; R. W. Norman

1993-01-01

398

Relationship Between Erectores Spinae Voltage and Back-Lift Strength for Isometric, Concentric, and Eccentric Contractions  

ERIC Educational Resources Information Center

|This study determined the maximal mean values for concentric and eccentric back-lift strength as well as isometric, and examined and compared the relationships between the mean peak voltage of the erectores spinae muscle(s) and maximal force exerted for the three types of muscle contractions. (RC)|

Ashton, T. Edwin J.; Singh, Mohan

1975-01-01

399

Isovelocity investigation of the lengthening behaviour of the erector spinae muscles  

Microsoft Academic Search

The purpose of this study was to investigate the force-velocity (F\\/) relationship for the erector spinae muscles in submaximal activation movements, with particular attention to their response during lengthening movements and at lower shortening contraction velocities. Dynamic models that predict lower back muscle forces require reasonable representations of the modulating effect of instantaneous velocity. Ten males were observed performing trunk

Chrisanto G. Sutarno; Stuart M. McGill

1995-01-01

400

Comparison of the Electromyographic Activation Level and Unilateral Selectivity of Erector Spinae during Different Selected Movements  

ERIC Educational Resources Information Center

|For patients with scoliosis, core stabilization exercises may be beneficial in improving muscle strength and trunk dynamic control. However, few studies have examined whether the erector spinae (ES) activation status during unilateral spinal extensor strengthening meets the guideline for patients with spinal scoliosis. To determine ES activation…

Guo, Lan-Yuen; Wang, Yu-Lin; Huang, Yu-Han; Yang, Chich-Haung; Hou, Yi-You; Harn, Hans I-Chen; You, Yu-Lin

2012-01-01

401

First case of Pseudoclavibacter bifida bacteremia in an immunocompromised host with chronic obstructive pulmonary disease (COPD).  

PubMed

Pseudoclavibacter spp. are Gram-positive, aerobic, catalase-positive, coryneform bacteria belonging to the family of Microbacteriaceae. Identification of these species with conventional biochemical assays is difficult. This case report of a Pseudoclavibacter bifida bacteremia occurring in an immunocompromised host diagnosed with an acute exacerbation of chronic obstructive pulmonary disease, with a lethal outcome, confirms that this organism may be a human pathogen. PMID:23536403

Oyaert, Matthijs; De Baere, Thierry; Breyne, Joke; De Laere, Emmanuel; Mariën, Stan; Waets, Peter; Laffut, Wim

2013-03-27

402

Longitudinal melanonychias.  

PubMed

Melanonychia is black or brown pigmentation that appears in the fingernails and toenails. The pigment can come from exogenous sources, such as bacteria or fungal infection, tar, or blood. Endogenous causes include aberrant melanin production in the nail bed, resulting in a longitudinal presentation. Melanonychia can indicate the presence of cancerous growths, as well as infection. Diagnostic measures, including dermatoscopy, biopsy, and histopathology, can determine the cause and direct the course of treatment. Malignant lesions should be excised, and underlying infections should be addressed with antibiotics or antifungals. Benign lesions and hyperpigmentation may benefit from a wait-and-see approach. PMID:24079589

Di Chiacchio, Nilton; Ruben, Beth S; Loureiro, Walter Refkalevsky

403

Electromyography of lumbar erector spinae muscles — influence of posture, interelectrode distance, strength, and fatigue  

Microsoft Academic Search

Summary  The aims of the study were to obtain information (1) on surface electromyograms (SEMG) from the lumbar erector spinae muscles\\u000a at different interelectrode distances and postures during short isometric contractions with constant force, (2) on the relationships\\u000a between SEMG and extension force at different postures, and (3) on changes in SEMG during fatiguing isometric contractions\\u000a at different postures and strengths.

Ronald Rosenburg; Helmut Seidel

1989-01-01

404

Volatile Constituents of the Leaves of Ziziphus spina-christi (L.) Willd. from Bushehr, Iran  

Microsoft Academic Search

The chemical composition of the oil of Ziziphus spina-christi (L.) Willd. leaves obtained by hydrodistillation were examined by capillary GC and GC\\/MS. Thirty-four components were characterized, representing 92.2% of the oil. The main components in the oil were geranyl acetone (14.0%), methyl hexadecanoate (10.0%), methyl octadecanoate (9.9%), farnesyl acetone C (9.9%), hexadecanol (9.7%) and ediyl octadecanoate (8.0%).

Alireza Ghannadi; Naser Tavakoli; Mozhgan Mehri-Ardestani

2003-01-01

405

The ethnobotany of Christ's Thorn Jujube (Ziziphus spina-christi) in Israel  

PubMed Central

This article surveys the ethnobotany of Ziziphus spina-christi (L.) Desf. in the Middle East from various aspects: historical, religious, philological, literary, linguistic, as well as pharmacological, among Muslims, Jews, and Christians. It is suggested that this is the only tree species considered "holy" by Muslims (all the individuals of the species are sanctified by religion) in addition to its status as "sacred tree " (particular trees which are venerated due to historical or magical events related to them, regardless of their botanical identity) in the Middle East. It has also a special status as "blessed tree" among the Druze.

Dafni, Amots; Levy, Shay; Lev, Efraim

2005-01-01

406

The influence of torque and velocity on erector spinae muscle fatigue and its relationship to changes of electromyogram spectrum density  

Microsoft Academic Search

The influence of contraction force and velocity during isokinetic contractions on the development of fatigue in the erector spinae muscle was studied. Seven male subjects performed a series of 250 contractions at 25% and 50% of their isometric maximal voluntary contraction (MVC) at 40 and 80°·s–1. Fatigue defined as a decrease of the contractile capacity of the muscles was studied

Jaap H. van Dieën; Barbara Böke; Willy Oosterhuis; Huub M. Toussaint

1996-01-01

407

Can Naturoptics fund Naturopathic Universities to Develop Interlocked Mentoring Relationships with Proposed Universities to Check Sensitivities of Individuals with Spina Bifida, to Environmentally Generated EMF Information about 'Quakes, Hurricanes, etc.?  

Microsoft Academic Search

Individuals harboring the herpes zoster virus following chicken pox, are susceptible to attacks of shingles. They may indicate peculiar awareness of pricking `pin and needle' sensations and co-symptoms of tinnitus and\\/or Meuniere's syndrome. RDM used similar symptoms in FL to predict the earthquake ninety miles north of Guantanamo bay in 1998. An astounding burial site in Florida from over six

David M. McLeod; Italani Ataide; Roger D. McLeod

2006-01-01

408

The electro-mechanical delay of the erector spinae muscle: influence of rate of force development, fatigue and electrode location  

Microsoft Academic Search

Summary  Electro-mechanical delay (EMD) values of the erector spinae muscle were obtained using a technique based on the cross-correlation between the force and the electromyogram (EMG). Seven subjects performed a series of 20 submaximal dynamic isometric contractions in a seated position at two frequencies (0.5 Hz and 1 Hz) to study the influence of the rate of force development on EMD.

J. H. van Dieën; C. E. A. M. Thissen; A. J. G. M. van de Ven; H. M. Toussaint

1991-01-01

409

The Longitudinal Approach  

ERIC Educational Resources Information Center

|Author, co-director of Britain's National Child Development Study, defines longitudinal studies and gives reasons for their particular contribution to educational thought and practice.'' (Editor/SP)|

Davie, Ronald

1972-01-01

410

Longitudinal Stability Calculations  

SciTech Connect

Coupled bunch longitudinal stability in the presence of high frequency impedances is considered. A frequency domain technique is developed and compared with simulations. The frequency domain technique allows for absolute stability tests and is applied to the problem of longitudinal stability in RHIC with the new 56 MHz RF system.

Blaskiewicz,M.

2009-01-02

411

Comparison of the electromyographic activation level and unilateral selectivity of erector spinae during different selected movements.  

PubMed

For patients with scoliosis, core stabilization exercises may be beneficial in improving muscle strength and trunk dynamic control. However, few studies have examined whether the erector spinae (ES) activation status during unilateral spinal extensor strengthening meets the guideline for patients with spinal scoliosis. To determine ES activation and whether unilateral selectivity shows a significant difference in the three designated exercises, we recorded the ES activity of 20 university students during these exercises. All participants had normal spinal flexibility without a history of, or current, spinal disease. The three stabilization exercise movements were quadruped, prone, and modified prone. We detected the activation level of bilateral ES using electromyography and normalized it with the maximum voluntary contraction. We determined unilateral selectivity by the ratio of the activation level between active and nonactive ES. The results showed that the modified prone movement caused the greatest muscle activity up to 41.6% of maximum voluntary contraction among other muscles (P<0.05). The quadruped and modified prone movements showed greater differences in bilateral sides (P<0.05) with a unilateral selectivity of 1.72 and 1.67, respectively. However, there was no significant difference in unilateral selectivity between quadruped and modified prone movements. Quadruped movement may be more suitable than the other two only for unilateral back extensor training. Nevertheless, for improvement in muscle strength, modified prone movement could also be considered. PMID:22785046

Guo, Lan-Yuen; Wang, Yu-Lin; Huang, Yu-Han; Yang, Chich-Haung; Hou, Yi-You; Harn, Hans I-Chen; You, Yu-Lin

2012-12-01

412

Presentation and Management of Hydromyelia in Children with Chiari Type-II Malformation  

Microsoft Academic Search

Hydromyelia in patients with myelomeningocele and Chiari-II malformation is a relatively frequent finding on MRI studies. However, not all children develop symptoms from the hydromyelia that requires treatment. Furthermore, treatment of hydromyelia in spina bifida patients is rather complex due to the associated malformations. The authors retrospectively analyzed 231 MRI studies carried out on spina bifida patients who presented neurological

Frank La Marca; Martin Herman; John A. Grant; David G. McLone

1997-01-01

413

Pathophysiology of Hydrocephalus  

Microsoft Academic Search

The three major clinical manifestations of spina bifida (hydrocephalus, paraplegia and urinary and bowel incontinence) are\\u000a easily observable and have been described since ancient times, though they were not described in relationship to spina bifida\\u000a until the seventeenth century [1].

Giuseppe Cinalli; Pietro Spennato; Maria Consiglio Buonocore; Emilio Cianciulli; Matthieu Vinchon; Spyros Sgouros

414

Brief Report: Testing the Factorial Invariance of the CBCL Somatic Complaints Scale as a Measure of Internalizing Symptoms for Children with and without Chronic Illness  

Microsoft Academic Search

Objective To examine the factorial invariance of the Somatic Complaints subscale of the Child Behavior Checklist as a measure of Internalizing Behavior Problems across a sample of children with and without spina bifida. Methods Multisample confirmatory factor analysis was used to compare mother and father report on the Somatic Complaints subscale across a sample of children with spina bifida and

Deborah Friedman; Fred B. Bryant; Grayson N. Holmbeck

2007-01-01

415

Subsequent Births in Families of Children with Disabilities: Using Demographic Data to Examine Parents' Reproductive Patterns  

ERIC Educational Resources Information Center

The authors determined family reproductive patterns after the birth of a child with (vs. without) a disability. Using Tennessee birth records, the authors examined families of children with Down syndrome (N = 1,123), spina bifida (N = 368), and population group (N = 734,189). Families of children with Down syndrome and with spina bifida were more…

Burke, Meghan M.; Urbano, Richard C.; Hodapp, Robert M.

2011-01-01

416

Brief Report: An Online Support Intervention--Perceptions of Adolescents with Physical Disabilities  

ERIC Educational Resources Information Center

Adolescents with cerebral palsy and spina bifida report restricted interactions with peers and gaps in social support. A pilot online support intervention offered interactions with peers. Five mentors with cerebral palsy or spina bifida and 22 adolescents with the same disabilities met weekly online for 25 group sessions over six months.…

Stewart, Miriam; Barnfather, Alison; Magill-Evans, Joyce; Ray, Lynne; Letourneau, Nicole

2011-01-01

417

Experimental Induction of Foetal Malformation with ``Blighted'' Potato: a Preliminary Report  

Microsoft Academic Search

SEVERAL reports have linked anencephaly and spina bifida with a dietary factor related to the consumption of potatoes. Recently Renwick1 has examined epidemiological data on anencephaly and spina bifida and postulates a link between the incidence of these neural dysplasias and the consumption of winter-stored ``blighted'' potatoes. He cites Leck and Record (unpublished results), who suggested that potatoes might become

D. E. Poswillo; Dinah Sopher; Sandra Mitchell

1972-01-01

418

Brief Report: An Online Support Intervention--Perceptions of Adolescents with Physical Disabilities  

ERIC Educational Resources Information Center

|Adolescents with cerebral palsy and spina bifida report restricted interactions with peers and gaps in social support. A pilot online support intervention offered interactions with peers. Five mentors with cerebral palsy or spina bifida and 22 adolescents with the same disabilities met weekly online for 25 group sessions over six months.…

Stewart, Miriam; Barnfather, Alison; Magill-Evans, Joyce; Ray, Lynne; Letourneau, Nicole

2011-01-01

419

Morbus de Anquin or spinous engagement syndrome  

Microsoft Academic Search

We report on a rare disease called to Anquin's disease or spinous engagement or impingement syndrome. Low-back pain in this specific syndrome probably combined with sciatica is caused by a hypertrophic spinous process along with a spina bifida occulta of the underlying vertebra. Mostly, the enlarged spinous process is seen at L5 and the spina bifida occulta at S I.

J. Bruns; U. Rehder; G. P. Dahmen; P. Behrens; L. Meiss

1994-01-01

420

Subsequent Births in Families of Children with Disabilities: Using Demographic Data to Examine Parents' Reproductive Patterns  

ERIC Educational Resources Information Center

|The authors determined family reproductive patterns after the birth of a child with (vs. without) a disability. Using Tennessee birth records, the authors examined families of children with Down syndrome (N = 1,123), spina bifida (N = 368), and population group (N = 734,189). Families of children with Down syndrome and with spina bifida were more…

Burke, Meghan M.; Urbano, Richard C.; Hodapp, Robert M.

2011-01-01

421

Conducting Longitudinal Studies  

ERIC Educational Resources Information Center

|Although time and resource intensive, longitudinal studies offer the ability to examine the direction and magnitude of causal relationships that cannot be accomplished through cross-sectional design. (Contains 1 figure.)|

Bauer, Karen W.

2004-01-01

422

Longitudinal Magnification Drawing Mistake  

NASA Astrophysics Data System (ADS)

Lateral magnification in image formation by positive lenses, mirrors, and dioptrics is usually appropriately developed in most optics textbooks.1-9 However, the image of a three-dimensional object occupies a three-dimensional region of space. The optical system affects both the transverse and the longitudinal dimensions of the object and, in general, does it in different ways. The magnification in the direction of the optical axis (the longitudinal magnification) is seldom treated. In several texts, the concept of longitudinal magnification is not even considered. Symmetrical objects (such as arrows) are used and their images appear laterally inverted. It is not shown how a longitudinally nonsymmetric object is imaged. One of the few books where this subject is well treated is in the textbook by Hecht.10 We have repeatedly verified in our classes that there is some confusion related to this subject. Students tend to believe that the image is longitudinally symmetric with respect to the lens optic center. Some prestigious texts commit the same mistake. In addition, a very nice optics book,11 a catalogue of optical hardware,12 a worldwide scientific magazine,13 a paper in an optics journal,14 and a Spanish encyclopedia,15 for example, have also been found to contain this error in drawing the image of a three-dimensional object formed by a positive lens. In this paper we suggest that the teaching of longitudinal magnification should be done with some care and we include a figure showing a properly drawn image.

Rabal, Héctor; Cap, Nelly; Trivi, Marcelo

2004-01-01

423

Resting mechanomyographic amplitude for the erector spinae and trapezius muscles following resistance exercise in a healthy population.  

PubMed

Musculoskeletal disorders are some of the most commonly occurring chronic conditions affecting the US population, with the most self-reported and diagnosed disorder being low back pain. Low back pain is often due to suboptimal back muscle function, at least in part, as a result of muscle inactivity and disuse. Resistance exercise has been shown to be successful in the treatment of low back pain. The purpose of the present investigation was to examine resting mechanomyographic (MMG) amplitude for the erector spinae and trapezius muscles prior to and following resistance exercise. Twenty healthy, college-aged men were measured for resting MMG amplitude levels prior to, and following a resistance training workout. The workout consisted of three sets of ten repetitions on the conventional deadlift, bent-over row, and lat pulldown exercises, with 1 min of rest between all sets and exercises. The results showed that there were approximate 10% and 15% decreases in normalized MMG amplitude after exercise for the erector spinae and trapezius muscles, respectively. These findings demonstrate a relaxation effect in the back muscles after exercise that could potentially be helpful in alleviating low back pain. PMID:24045398

Wages, Nathan P; Beck, Travis W; Ye, Xin; Hofford, Craig W

2013-09-18

424

Idiopathic Polydactylous Longitudinal Erythronychia  

PubMed Central

Objective: To describe the clinical features of idiopathic polydactylous longitudinal erythronychia. Introduction: Longitudinal erythronychia presents as a linear red band on the nail plate. Idiopathic polydactylous longitudinal erythronychia is a rarely described manifestation of longitudinal erythronychia in which one or more linear red bands present on the nails of multiple digits without any associated subungual malignant tumor, dermatological condition, or systemic disease. Methods: As part of a total body skin examination, the fingernails and toenails were evaluated for linear red bands. Results: One or more asymptomatic linear red bands (longitudinal erythronychia) was observed on multiple digits of the hands in one percent (3 men of 134 men and 112 women) of patients examined during a period of 75 days. The author also noted similar changes of his own nails. Between 3 to 10 digits were affected. Multiple linear red bands per nail were usually narrow (less than 1mm wide), whereas a single band on a nail often ranged from 4 to 6mm wide. The intensity of an individual wider linear red band was position-dependent in three individuals in whom the distal portion appeared less prominent when the affected digit was held upward above the level of the patient's heart—pseudolongitudinal erythronychia. Other nail changes in these patients included distal subungual hyperkeratosis, fissuring at the free end of the nail, leukonychia, red lunula, and splinter hemorrhages. Discussion: Idiopathic polydactylous longitudinal erythronychia is a benign, usually asymptomatic, condition of undetermined etiology characterized by one or more linear red bands originating at the proximal nail fold or distal lunula and extending to the free edge of the nail. It appears to be more prevalent in men over 50 years of age and its incidence was noted to be one percent of adults attending a dermatology clinic. Patients are either unaware of the nail changes or seek medical attention because of the nail plate appearance. Other nail changes can concurrently be observed including pseudolongitudinal erythronychia in which the distal intensity of an individual wider red band is less pronounced when the digit is held upward. Idiopathic polydactylous longitudinal erythronychia has not been associated with benign or malignant subungual tumors, dermatological conditions, or systemic diseases. Conclusion: Idiopathic polydactylous longitudinal erythronychia may represent as a benign, possibly age-related, nail change without any associated local or systemic adverse sequellae.

2011-01-01

425

WISCONSIN LONGITUDINAL STUDY (WLS)  

EPA Science Inventory

The Wisconsin Longitudinal Study (WLS) is a long-term study of a random sample of 10,317 men and women who graduated from Wisconsin high schools in 1957. The WLS provides an opportunity to study of the life course, intergenerational transfers and relationships, family functioning...

426

Longitudinal data model selection  

Microsoft Academic Search

In longitudinal data with correlated errors, we apply the likelihood and residual likelihood approaches to obtain the corrected Akaike information criterion (AICc) and the residual information criterion (RIC), respectively. Simulation studies show that AICc outperforms the Akaike information criterion (AIC) when the numbers of subjects and repeated observations are small, and RIC is superior to the Bayesian information criterion (BIC)

Rahman Azari; Lexin Li; Chih-ling Tsai

2006-01-01

427

Longitudinal Tire Dynamics  

Microsoft Academic Search

This article begins with a brief review of the traditional concept of lateral relaxation length. The review illustrates that this concept yields a useful approximation which can be used with semi-empirical tire models which assume lateral forces are a function of steady-state slip angles. The article then presents an analogous derivation for longitudinal slip. Like its lateral counterpart, the derivation

C. L. CLOVER; J. E. BERNARD

1998-01-01

428

Longitudinal Ionization Cooling of Muons  

NASA Astrophysics Data System (ADS)

Longitudinal ionization cooling is investigated using equations for moments derived from equations of motion for individual particles. An evolution of moments in time is calculated by use of Laplace transform method. It is shown that if longitudinal damping coefficient is much more than the frequency of longitudinal oscillations a rate of emittance damping becomes much slower leading to additional muon losses (Z. Parsa, P. Zenkevich, ``Kinetics of Muon Longitudinal Cooling'', ITP96 Report, to be published.)

Parsa, Z.; Zenkevich, P.

1997-05-01

429

Longitudinal-Experimental Studies  

Microsoft Academic Search

\\u000a Longitudinal-experimental studies are follow-up surveys that include an experimental intervention. The main advantage of these\\u000a surveys is that it is possible to study both the natural history of development and the impact of interventions in one research\\u000a project. This chapter focusses on large-scale community surveys with repeated personal interviews with participants spanning\\u000a at least 5 years. It reviews the advantages

David P. Farrington; Rolf Loeber; Brandon C. Welsh

430

ALS longitudinal kickers  

SciTech Connect

This paper discusses the coupled-bunch instability and how it applies to the ALS accelerator. The longitudinal ALS kicker is part of the bunch-to-bunch feedback system planned to control coupled-bunch instabilities in the ALS. The mechanical features of the kicker are described, and the analytic tools developed to aid in the design are discussed. A method to predict the performance of the kicker in the accelerator from measurements on a prototype are described.

Voelker, F.

1992-10-01

431

The influence of torque and velocity on erector spinae muscle fatigue and its relationship to changes of electromyogram spectrum density.  

PubMed

The influence of contraction force and velocity during isokinetic contractions on the development of fatigue in the erector spinae muscle was studied. Seven male subjects performed a series of 250 contractions at 25% and 50% of their isometric maximal voluntary contraction (MVC) at 40 and 80 degree.s-1. Fatigue defined as a decrease of the contractile capacity of the muscles was studied by means of a 15-s maximal test-contraction following the exercise. Both the initial force and the force decrement during the test-contraction were studied. Surface electromyogram (EMG) signals of the main tracts of the erector spinae muscle were recorded. The frequency content was studied by calculating the zero-crossing rate for the signals obtained during dynamic contractions and by means of fast Fourier transformation for the test contraction. After the 50% MVC dynamic contractions the initial force during the postexercise test-contraction was significantly lower than after the 25% MVC contractions. No significant influence of contraction velocity on fatigue development was found. The force decrement during the test-contraction did not depend on the experimental conditions. The EMG amplitude indicated that the subjects were better able to relax their muscles during the counter movement (flexion) at high forces and high velocities compared to the other experimental conditions. The frequency content of the EMG signals during the dynamic contractions and the postexercise test-contraction showed only very weak relationships with fatigue. Therefore, spectrum EMG parameters as determined in the present study do not seem suitable as indicators of muscle fatigue as a consequence of dynamic contractions of trunk extensor muscles. PMID:8851899

van Dieën, J H; Böke, B; Oosterhuis, W; Toussaint, H M

1996-01-01

432

Longitudinal Spin Seebeck Effect  

NASA Astrophysics Data System (ADS)

The spin Seebeck effect (SSE) refers to the generation of a spin voltage as a result of a temperature gradient in magnetic materials [1-7]. Here, a spin voltage is a potential for electron spins to drive a nonequilibrium spin current; when a conductor is attached to a magnet with a finite spin voltage, it induces a spin injection into the conductor. The SSE is of crucial importance in spintronics and spin caloritronics, since it enables simple and versatile generation of a spin current from heat. The simplest and most straightforward setup of the SSE is the longitudinal configuration [4], in which a spin current flowing parallel to a temperature gradient is measured via the inverse spin Hall effect (ISHE). The longitudinal SSE device consists of a ferromagnetic or ferrimagnetic insulator (FI, e.g. YIG) covered with a paramagnetic metal (PM, e.g. Pt) film. When a temperature gradient is applied perpendicular to the FI/PM interface, an ISHE-induced voltage is generated in the PM layer. In this talk, we report the observation of the longitudinal SSE in various FI/PM systems and provide evidence that the longitudinal SSE is free from thermoelectric artefact [7], i.e., the anomalous Nernst effect caused by extrinsic magnetic proximity [8]. Then, we discuss the longitudinal SSE from an application point of view [6]. We thank E. Saitoh, S. Maekawa, G. E. W. Bauer, X.-F. Jin, H. Adachi, D. Hou, D. Tian, T. Kikkawa, A. Kirihara, and M. Ishida for their support and valuable discussions. [4pt] [1] K. Uchida et al., Nature 455, 778 (2008).[0pt] [2] K. Uchida et al., Nature Mater. 9, 894 (2010).[0pt] [3] C. M. Jaworski et al., Nature Mater. 9, 898 (2010).[0pt] [4] K. Uchida et al., Appl. Phys. Lett. 97, 172505 (2010).[0pt] [5] K. Uchida et al., Nature Mater. 10, 737 (2011).[0pt] [6] A. Kirihara et al., Nature Mater. 11, 686 (2012).[0pt] [7] T. Kikkawa et al., arXiv:1211.0139 (2012). [0pt] [8] S. Y. Huang et al., Phys. Rev. Lett. 109, 107204 (2012).

Uchida, Ken-Ichi

2013-03-01

433

Fundamentals---longitudinal motion  

SciTech Connect

I will cover acceleration and longitudinal motion in a synchrotron. What I hope to add (to the current literature) is a unified overview of the related rf subjects in an accelerator and a close coupling between accelerator physics and engineering practices, which is essential for the major progress in areas such as high intensity synchrotrons, a multistage accelerator complex, and anti/minus/proton production cooling, made possible in the past 20 years. I also hope that after this summer school, you will have the basic knowledge to let you understand the discussion and to ease the way for you to dip into the field if you so choose. (AIP)

Weng, W. T.

1989-04-01

434

Longitudinal multichannel optoelectronic deformometer  

Microsoft Academic Search

Conclusion  Based on laboratory and full-scale (on-site) tests, the developed basic model of the MO?D-Ip longitudinal-type multichannel\\u000a optoelectronic deformometer appears to match its design specifications. Laboratory experiments using acoustic channels have\\u000a demonstrated the unique possibility of application of individual measuring modules of the MO?D-Ip instrument system for diagnosis\\u000a and monitoring of the state of block media in terms of their loading

M. V. Kurlenya; V. N. Oparin; A. A. Akinin; G. G. Sidenko; V. F. Yushkin

1997-01-01

435

Kinetics of muon longitudinal cooling  

SciTech Connect

Kinetics of longitudinal ionization cooling is analysed by use of method of moments. Special attention is given to ''supercooling'' situation when longitudinal damping coefficient is much more than synchrotron frequency. It is shown that in this case the emittance damping becomes slower, and it should be taken into account in designing of the ionization cooling system.

Parsa, Zohreh [Department of Physics, Bldg. 901A, Brookhaven National Laboratory, P.O. Box 5000 Upton, New York 11973-5000 (United States); Zenkevich, Pavel [Institute for Theoretical and Experimental Physics, B Cheremushkinskaya Ulitsa 25, RU-117 259, Moscow (Russian Federation)

1997-04-10

436

Muscle fiber types in thoracic erector spinae muscles. Fiber types in idiopathic and other forms of scoliosis.  

PubMed

Histochemical studies of the thoracic part of the erector spinae muscles in scoliosis have shown a consistently higher proportion of Type 1 fibers on the convex side. The fiber distribution of the multifidus and semispinalis muscles was studied in adolescent idiopathic scoliosis (AIS). Compared with sex- and age-matched controls, a "normal" percentage of Type 1 fibers was found on the convex right side and significantly smaller percentage of Type 1 fibers on the concave side. Boys with AIS showed the same pattern as girls. In two patients with double major curves, the same pattern could be seen on the convexity of both curves. Patients with congenital scoliosis or scoliosis with early onset showed a different pattern with a "normal" percentage of Type 1 fibers on the concave side but a significantly greater percentage of Type 1 fibers on the convex side. In AIS, the deviation in the fiber distribution may constitute a primary factor in the pathogenesis of scoliosis. In congenital scoliosis the differences in fiber distribution between the convex and concave sides are considered secondary in the pathogenesis of the spinal curvature. PMID:3791746

Bylund, P; Jansson, E; Dahlberg, E; Eriksson, E

1987-01-01

437

Kinetics of muon longitudinal cooling  

SciTech Connect

Kinetics of longitudinal ionization cooling is analysed by use of method of moments. Special attention is given to {open_quotes}supercooling{close_quotes} situation when longitudinal damping coefficient is much more than synchrotron frequency. It is shown that in this case the emittance damping becomes slower, and it should be taken into account in designing of the ionization cooling system. {copyright} {ital 1997 American Institute of Physics.}

Parsa, Zohreh [Department of Physics, Bldg. 901A, Brookhaven National Laboratory, P.O. Box 5000 Upton, New York11973-5000] Zenkevich, Pavel [Institute for Theoretical and Experimental Physics, B Cheremushkinskaya Ulitsa 25, RU-117259, Moscow (Russia)

1997-04-01

438

76 FR 52572 - Rules Governing Hearings Before the Agency of Original Jurisdiction and the Board of Veterans...  

Federal Register 2010, 2011, 2012, 2013

...Sec. Sec. 20.1 and 20.1304 to ensure they do not cause any confusion regarding the correct applicability of...Veterans' Children with Spina Bifida or Other Covered Birth Defects. Signing Authority The Secretary of Veterans...

2011-08-23

439

38 CFR 21.8282 - Termination of a vocational training program.  

Code of Federal Regulations, 2010 CFR

...Veterans-Spina Bifida and Covered Birth Defects Vocational Training...under this subpart for cause, including lack of...longer has a covered birth defect. An eligible child...longer has a covered birth defect. The effective...

2009-07-01

440

38 CFR 21.8282 - Termination of a vocational training program.  

Code of Federal Regulations, 2010 CFR

...Veterans-Spina Bifida and Covered Birth Defects Vocational Training...under this subpart for cause, including lack of...longer has a covered birth defect. An eligible child...longer has a covered birth defect. The effective...

2010-07-01

441

77 FR 895 - Tribal Child Welfare  

Federal Register 2010, 2011, 2012, 2013

...that adversely affects the child's day-to-day motor functioning, such as cerebral palsy, spina bifida, multiple sclerosis, orthopedic impairments, and other physical disabilities. Emotionally Disturbed (DSM III)--A...

2012-01-06

442

Neuromuscular Diseases and Conditions (and Oral Health)  

MedlinePLUS

Neuromuscular Diseases and Conditions Bell's Palsy Epilepsy Multiple Sclerosis Cerebral Palsy Muscular Dystrophy Parkinson's Disease Huntington's Disease Myasthenia Gravis Spina Bifida Bell's Palsy Oral Effects Bell's palsy is a temporary paralysis of ...

443

77 FR 60746 - Proposed Information Collection (Award Attachment for Certain Children With Disabilities Born of...  

Federal Register 2010, 2011, 2012, 2013

...Award Attachment for Certain Children With Disabilities Born of...determine a spina bifida child of Vietnam veterans' eligibility...other forms of information technology. Title: Award Attachment for Certain Children with Disabilities Born...

2012-10-04

444

Transitions into Adolescence  

MedlinePLUS

... one's heallth care. Sexuality and Spina Bifida Helps adolescents, young adults and their caregivers discuss sexuality in an informative manner by providing information on the physical and social aspects of sexuality from a developmental ...

445

Dear Jamie  

ERIC Educational Resources Information Center

|The letter from an adult woman handicapped by spina bifida myelomeningocele is addressed to an adolescent similarly handicapped and focuses on problems of emotional adjustment and coping with bladder incontinence. (DB)|

Helton, Sandra

1974-01-01

446

38 CFR 21.8284 - Additional vocational training.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Vocational Training Program Entrance, Termination, and Resources § 21.8284...

2013-07-01

447

38 CFR 21.8016 - Nonduplication of benefits.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects General § 21.8016 Nonduplication of benefits. (a) Election of...

2013-07-01

448

38 CFR 21.8286 - Training resources.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Vocational Training Program Entrance, Termination, and Resources § 21.8286...

2013-07-01

449

38 CFR 21.8310 - Rate of pursuit.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Rate of Pursuit § 21.8310 Rate of pursuit. (a) General requirements....

2013-07-01

450

76 FR 73020 - Agency Information Collection (Request for Transportation Expense Reimbursement): Activity Under...  

Federal Register 2010, 2011, 2012, 2013

...Type of Review: Extension of a currently approved collection. Abstract: Children of Vietnam veterans born with spina bifida and receiving vocational training or seeking employment may request reimbursement for transportation expenses. To...

2011-11-28

451

38 CFR 21.8022 - Entry and reentry.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Basic Entitlement Requirements § 21.8022 Entry and reentry. (a) Date of...

2013-07-01

452

Alpha fetoprotein  

MedlinePLUS

... be done along with amniocentesis to help detect spina bifida or other birth defects in the developing baby. ... Birth defects, including: Anencephaly Duodenal atresia Gastroschisis ... of Fallot Turner syndrome Genetic disorders, including ...

453

Areas of Responsibility in the Health Care of Multiply Handicapped Children  

ERIC Educational Resources Information Center

Forty-four mothers of children ages birth to 17-years-old with spina bifida were interviewed to determine whether primary physicians, specialists or other sources had taken responsibility for providing each of nine areas of health care. (CL)

Kanthor, Harold; And Others

1974-01-01

454

A Legal Brief: Very Special Education.  

ERIC Educational Resources Information Center

Discusses previous litigation relevant to the case of a child suffering from "spina bifida" whose parents have brought suit against a Texas school district for failing to include catheterization in the child's individual education program. (Author/WD)

Zirkel, Perry A.; Gluckman, Ivan B.

1981-01-01

455

Dear Jamie  

ERIC Educational Resources Information Center

The letter from an adult woman handicapped by spina bifida myelomeningocele is addressed to an adolescent similarly handicapped and focuses on problems of emotional adjustment and coping with bladder incontinence. (DB)

Helton, Sandra

1974-01-01

456

38 CFR 21.8410 - Delegation of authority.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Delegation of Authority § 21.8410 Delegation of authority. The Secretary...

2013-07-01

457

38 CFR 17.905 - Medical records.  

Code of Federal Regulations, 2013 CFR

...MEDICAL Health Care Benefits for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects § 17.905 Medical records. Copies of medical records generated outside VA...

2013-07-01

458

38 CFR 21.8100 - Counseling.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Counseling § 21.8100 Counseling. An eligible child requesting or...

2013-07-01

459

38 CFR 21.8370 - Authorization of transportation services.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Transportation Services § 21.8370 Authorization of transportation services....

2013-07-01

460

38 CFR 21.8050 - Scope of training, services, and assistance.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Services and Assistance to Program Participants § 21.8050 Scope of training,...

2013-07-01

461

38 CFR 21.8280 - Effective date of induction into a vocational training program.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Vocational Training Program Entrance, Termination, and Resources § 21.8280...

2013-07-01

462

38 CFR 17.904 - Review and appeal process.  

Code of Federal Regulations, 2013 CFR

...MEDICAL Health Care Benefits for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects § 17.904 Review and appeal process. For purposes of §§...

2013-07-01

463

38 CFR 21.8260 - Training, services, and assistance costs.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Program Costs § 21.8260 Training, services, and assistance costs. The...

2013-07-01

464

Urban-Rural Variation in the Occurrence of Neural Tube Defects in Texas  

EPA Science Inventory

This study examined the pattern and magnitude of urban-rural variation in anencephaly, spina bifida without anencephaly, and encephalocele in Texas using four different indicators of urban-rural status for the period 1999 to 2003....

465

38 CFR 21.8320 - Authorization of services.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Authorization of Services § 21.8320 Authorization of services. The...

2013-07-01

466

38 CFR 21.8015 - Notification by VA of necessary information or evidence when a claim is filed; time for claimant...  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects General § 21.8015 Notification by VA of necessary information or evidence when...

2013-07-01

467

38 CFR 17.805 - Additional terms of loans.  

Code of Federal Regulations, 2013 CFR

...501) Health Care Benefits for Certain Children of Vietnam Veterans and Veterans with Covered Service in KoreaâSpina Bifida and Covered Birth Defects Source: 68 FR 1010, Jan. 8, 2003, unless otherwise...

2013-07-01

468

38 CFR 21.8210 - Supplies.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Supplies § 21.8210 Supplies. (a) Purpose of furnishing supplies. VA...

2013-07-01

469

Related Services and the Supreme Court: A Family's Story.  

ERIC Educational Resources Information Center

The article describes the efforts of a woman in securing, through court litigation, clean intermittent catheterization as a related service for her child with spina bifida. Effects of the decision process on the mother, family, and child are noted. (CL)

Tatro, Mary

1984-01-01

470

38 CFR 21.8380 - Additional applicable regulations.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Additional Applicable Regulations § 21.8380 Additional applicable...

2013-07-01

471

Children with Disabilities Who Use Assistive Technology: Ethical Considerations.  

ERIC Educational Resources Information Center

Discusses some of the ethical concerns that early childhood professionals should consider when identifying or adapting assistive technologies for young children with such disabilities as cerebral palsy, spina bifida, visual impairments, and hearing impairments. (BB)

Holder-Brown, Loreta; Parette, Howard P. Jr.

1992-01-01

472

38 CFR 21.8360 - Satisfactory conduct and cooperation.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Satisfactory Conduct and Cooperation § 21.8360 Satisfactory conduct and...

2013-07-01

473

WRITTEN REQUEST – AMENDMENT 1 NDA 20-579 ...  

Center for Drug Evaluation (CDER)

Text Version... of pediatric patients 2 years – 16 years of age with elevated detrusor LPP associated with a known neurological disorder (eg spina bifida) to ensure ... More results from www.fda.gov/downloads/drugs/developmentapprovalprocess

474

38 CFR 21.8340 - Leaves of absence.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Leaves of Absence § 21.8340 Leaves of absence. (a) Purpose of leave of...

2013-07-01

475

38 CFR 21.8282 - Termination of a vocational training program.  

Code of Federal Regulations, 2013 CFR

...Vocational Training and Rehabilitation for Certain Children of Vietnam Veterans and Veterans with Covered Service in Korea-Spina Bifida and Covered Birth Defects Vocational Training Program Entrance, Termination, and Resources § 21.8282...

2013-07-01

476

Medical Journal. Volume 92, Number 10, 1970.  

National Technical Information Service (NTIS)

Contents: Apparent cardiac patients; Further studies on the use and anatomic basis of the Lazarevic-Lasegue Test; Lumbosacral lipoma developed on a spina bifida occulta in adults; Fractures of the femoral neck in aged people; Colon duplex; Panreatic micro...

1971-01-01

477

Spinal dysraphism.  

PubMed

To review the clinical features and current understanding of spina bifida with an emphasis on the Indian Scenario. Selected articles and current English language texts were reviewed. The authors experience was also reviewed and analysed. Spina bifida is a common congenital anomaly encompassing a wide spectrum of neural tube defects.It is broadly classified as spina bifida aperta and occulta. With the prenatal screening, the incidence of aperta is gradually declining, whereas the detection of occulta has increased with the advent of magnetic resonance imaging. Over the years, the understanding of pathophysiology has made a significant changein the management of these anomalies. Early detection and complete correction can significantly reduce the neurological disability. This article is an overview of spina bifida with a special emphasis on Indian scenario. PMID:22069428

Venkataramana, N K

2011-10-01

478

Oxybutynin  

MedlinePLUS

... overactive bladder (a condition in which the bladder muscles have uncontrollable spasms), spina bifida (a disability that ... birth), or other conditions that affect the bladder muscles. Oxybutynin is in a class of medications called ...

479

38 CFR 21.8012 - Vocational training program for certain children of Vietnam veterans and veterans with covered...  

Code of Federal Regulations, 2013 CFR

38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Vocational training program for certain children of Vietnam veterans and veterans with covered service in Korea-spina bifida and...

2013-07-01

480

45 CFR Appendix C to Part 84 - Guidelines Relating to Health Care for Handicapped Infants  

Code of Federal Regulations, 2010 CFR

...illustrative examples to assist in understanding the framework for...correct an intestinal obstruction in an infant with Down's Syndrome when the withholding is based...correctable physical anomalies in children born with spina bifida when...

2009-10-01

481

Spinal lipoma associated with terminal syringohydromyelia and a spinal arachnoid cyst in a patient with cloacal exstrophy  

Microsoft Academic Search

Case report. A 2-year-old girl presented with repaired cloacal exstrophy and a subcutaneous mass at the midline of the lumbosacral region. Neurological examination revealed mild paraparesis with bilateral lower-extremity hyperreflexia and sensory disturbance below the level of L4. A CT scan showed asymmetrical spina bifida on the right side extending from L2 to L5, and symmetrical spina bifida below S1.

Miki Fujimura; Yasuko Kusaka; Reizo Shirane

2003-01-01

482

Longitudinal excitations in quantum antiferromagnets.  

PubMed

By extending our recently proposed magnon-density waves to low dimensions, we investigate, using a microscopic many-body approach, the longitudinal excitations of the quasi-one-dimensional (quasi-1d) and quasi-2d Heisenberg antiferromagnetic systems on a bipartite lattice with a general spin quantum number. We obtain the full energy spectrum of the longitudinal mode as a function of the coupling constants in the original lattice Hamiltonian and find that it always has a nonzero energy gap if the ground state has a long-range order and becomes gapless for the pure isotropic 1d model. The numerical value of the minimum gap in our approximation agrees with that of a longitudinal mode observed in the quasi-1d antiferromagnetic compound KCuF(3) at low temperature. It will be interesting to compare values of the energy spectrum at other momenta if their experimental results are available. PMID:21841234

Xian, Y

2011-08-12

483

Passive longitudinal phase space linearizer  

NASA Astrophysics Data System (ADS)

We report on the possibility to passively linearize the bunch compression process in electron linacs for the next generation x-ray free electron lasers. This can be done by using the monopole wakefields in a dielectric-lined waveguide. The optimum longitudinal voltage loss over the length of the bunch is calculated in order to compensate both the second-order rf time curvature and the second-order momentum compaction terms. Thus, the longitudinal phase space after the compression process is linearized up to a fourth-order term introduced by the convolution between the bunch and the monopole wake function.

Craievich, P.

2010-03-01

484

Longitudinal motion in circular accelerators  

SciTech Connect

A general description is given of the longitudinal motion of an idealized synchronous particle, exactly in step with the radiofrequency field of a circular accelerator, and a domain in phase and energy, called a bucket, around this particle within which particles are focused around the synchronous particle. This general picture is then made more precise and quantitative. The equations of longitudinal motion and their solutions and the resulting motion are discussed, followed by applications and amplication of the theory. 7 refs., 8 figs. (LEW)

Cole, F.T.

1985-01-01

485

Matching surveys in longitudinal studies  

Microsoft Academic Search

This research addresses the issue of linking baseline and followup surveys in longitudinal studies. In the past, Social Security Number (SSN) was commonly used as a matching variable between survey waves, but reluctance to provide this information reduced matches. Optical scanning errors can also produce mismatches between otherwise matching surveys. Two matching methods were developed for a smoking survey that

Cynthia B. Augustine; Scott Ginder; Kristine L. Rae Olmsted

2008-01-01

486

Longitudinal Observation of Infant Temperament  

ERIC Educational Resources Information Center

Convergent validity, temporal stability, and age-related patterning of measures of infant temperament were examined in a longitudinal study of 46 infants at three, six, and nine months of age. Infant Behavior Questionnaire and home observations showed convergent validity. Composite measures of positive and negative reactivity and overall…

Rothbart, Mary Klevjord

1986-01-01

487

LONGITUDINAL STUDY OF AGING (LSOA)  

EPA Science Inventory

The Longitudinal Study of Aging (LSOA) is a collaborative effort of the National Center for Health Statistics (NCHS) and the National Institute on Aging (NIA). The Supplement on Aging (SOA), conducted in conjunction with the 1984 National Health Interview Survey (NHIS), served as...

488

Consistent Sulcal Parcellation of Longitudinal Cortical Surfaces  

PubMed Central

Automated accurate and consistent sulcal parcellation of longitudinal cortical surfaces is of great importance in studying longitudinal morphological and functional changes of human brains, since longitudinal cortical changes are normally very subtle, especially in aging brains. However, applying the existing methods (which were typically developed for cortical sulcal parcellation of a single cortical surface) independently to longitudinal cortical surfaces might generate longitudinally-inconsistent results. To overcome this limitation, this paper presents a novel energy function based method for accurate and consistent sulcal parcellation of longitudinal cortical surfaces. Specifically, both spatial and temporal smoothness are imposed in the energy function to obtain consistent longitudinal sulcal parcellation results. The energy function is efficiently minimized by a graph cuts method. The proposed method has been successfully applied to sulcal parcellation of both real and simulated longitudinal inner cortical surfaces of human brain MR images. Both qualitative and quantitative evaluation results demonstrate the validity of the proposed method.

Li, Gang; Shen, Dinggang

2011-01-01

489

Bunched beam longitudinal instability: Coherent dipole motion.  

National Technical Information Service (NTIS)

In this paper, the authors present a new formulation for the longitudinal coherent dipole motion, where a quadrature response of the environmental impedance is shown to be the effective longitudinal impedance for the beam instability. The Robinson-Pederse...

S. Y. Zhang W. T. Weng

1993-01-01

490

Families of Children with Mental Retardation: Effective Collaboration.  

ERIC Educational Resources Information Center

This paper discuses the findings of a research study that compared 191 families of children with spina bifida and 145 families of children with mental retardation. Findings include: (1) mothers of children with developmental disabilities (DD) perceived that they experienced more poor health/mood problems than the mothers of children with Spina

Singh, Delar K.

491

Longitudinal bulk acoustic mass sensor  

SciTech Connect

A polycrystalline silicon longitudinal bulk acoustic cantilever is fabricated and operated in air at 51 MHz. A mass sensitivity of 100 Hz/fg (1 fg=10{sup -15} g) is obtained from the preliminary experiments where a minute mass is deposited on the device by means of focused ion beam. The total noise in the currently applied measurement system allows for a minimum detectable mass of 0.5 fg in air.

Hales, J. H.; Teva, J.; Boisen, A.; Davis, Z. J. [Department of Micro and Nanotechnology-DTU Nanotech, Technical University of Denmark, DTU Bldg. 345 East, DK-2800 Kongens Lyngby (Denmark)

2009-07-20

492

Prosocial development: A longitudinal study  

Microsoft Academic Search

Examined, using a longitudinal methodology, (1) the development of prosocial moral judgment and (2) the relation between prosocial moral judgment and both prohibition-oriented moral judgment and maternal childrearing practices. Three samples were tested: 33 82–99 mo olds were interviewed 3 times; 16 49–67 mo olds were interviewed twice; and 30 2nd graders were interviewed once. From preschool to elementary school

Nancy Eisenberg; Randy Lennon; Karlsson Roth

1983-01-01

493

Passive longitudinal phase space linearizer  

Microsoft Academic Search

We report on the possibility to passively linearize the bunch compression process in electron linacs for the next generation x-ray free electron lasers. This can be done by using the monopole wakefields in a dielectric-lined waveguide. The optimum longitudinal voltage loss over the length of the bunch is calculated in order to compensate both the second-order rf time curvature and

P. Craievich

2010-01-01

494

Antifungal activity of nettle (Urtica dioica L.), colocynth (Citrullus colocynthis L. Schrad), oleander (Nerium oleander L.) and konar (Ziziphus spina-christi L.) extracts on plants pathogenic fungi.  

PubMed

Anti-mycotic activity of the ethanol extracts from Nettle (Urtica dioica L.), Colocynth (Citrullus colocynthis L. Schrad), Konar (Ziziphus spina-christi L.) and Oleander (Nerium oleander L.) floral parts were screened in vitro against four important plant pathogenic fungi viz.; Alternaria alternate, Fusarium oxysporum, Fusarium solani and Rizoctonia solani using agar dilution bioassay. Extracts showed antifungal activity against all the tested fungi. Among the plants, Nettle and Colocynth were the most effective against A. alternate and R. solani while Oleander possesses the best inhibition on F. oxysporum and F. solani. Konar was the most effective extract by reducing the growth of Rizoctonia solani than other fungi. These results showed that extracts could be considered suitable alternatives to chemical additives for the control of fungal diseases in plants. PMID:19579919

Hadizadeh, I; Peivastegan, B; Kolahi, M

2009-01-01

495

Transverse-longitudinal integrated resonator  

DOEpatents

A transverse-longitudinal integrated optical resonator (TLIR) is disclosed which includes a waveguide, a first and a second subwavelength resonant grating in the waveguide, and at least one photonic band gap resonant structure (PBG) in the waveguide. The PBG is positioned between the first and second subwavelength resonant gratings. An electro-optic waveguide material may be used to permit tuning the TLIR and to permit the TLIR to perform signal modulation and switching. The TLIR may be positioned on a bulk substrate die with one or more electronic and optical devices and may be communicably connected to the same. A method for fabricating a TLIR including fabricating a broadband reflective grating is disclosed. A method for tuning the TLIR's transmission resonance wavelength is also disclosed.

Hutchinson, Donald P [Knoxville, TN; Simpson, Marcus L [Knoxville, TN; Simpson, John T [Knoxville, TN

2003-03-11

496

Longitudinal trends in academic web links  

Microsoft Academic Search

Longitudinal studies of web change are needed to assess the stability of webometric statistics and this paper forms part of an on-going longitudinal study of three national academic web spaces. It examines the relationship between university inlinks and research productivity over time and identifies reasons for individual universities experiencing significant increases and decreases in inlinks over the last six years.

Nigel Payne; Mike Thelwall

2008-01-01

497

Longitudinal Studies: Designs, Validity, Practicality, and Value  

ERIC Educational Resources Information Center

|Aiming to encourage longitudinal studies in science education, we clarify conceptual and methodological aspects of longitudinal research. We use the studies that other articles in this issue describe to illustrate these aspects. The illustrations range from attempts to promote long-term change through experimental teaching to investigations that…

White, Richard T.; Arzi, Hanna J.

2005-01-01

498

College Women's Female Friendships: A Longitudinal View  

ERIC Educational Resources Information Center

|This article presents a longitudinal qualitative study of the cognitive value of female friendships formed in college and seeks to appraise the meaning of the phenomenon for the participants. To grasp the temporal effects of the longitudinal data in this study, the author examines and assesses the relevant developmental literature, particularly…

Aleman, Ana M. Martinez

2010-01-01

499

Modeling a Longitudinal Relational Research Data Systems  

ERIC Educational Resources Information Center

|A study was conducted to propose a research-based model for a longitudinal data research system that addressed recommendations from a synthesis of literature related to: (1) needs reported by the U.S. Department of Education, (2) the twelve mandatory elements that define federally approved state longitudinal data systems (SLDS), (3) the…

Olsen, Michelle D. Hunt

2010-01-01

500

Longitudinal Control of a Platoon of Vehicles  

Microsoft Academic Search

This paper presents a systematic analysis of a longitudinal control law for a platoon of non-identical vehicles using a non-linear model to represent the vehicle dynamics of each vehicle within the platoon. The basic idea is to take full advantage of recent advances in communication and measurement and using these advances in longitudinal control of a platoon of vehicles: in

Shahab Sheikholeslam; Charles A. Desoer

1990-01-01