Florfenicol broad-spectrum antibiotic developed veterinary application oral concentrate intended dilution drinking water. drug product dosed via drinking water farm setting number variables including pH chlorine content hardness water dilution container material affect stability leading decrease drug potency. stability florfenicol after dilution Florfenicol Drinking Water Concentrate Oral Solution 23 mg/mL drinking water studied. stability-indicating validated liquid chromatographic method evaluate florfenicol stability 25 degrees 5 10 24 h after dilution. results indicate florfenicol stable under range simulated field conditions including pipe materials conditions hard soft chlorinated nonchlorinated water low high pH. Significant degradation ( 10%) observed only isolated combinations Stability florfenicol drinking water Hayes JM Eichman J Katz T Gilewicz R
Development and application of a novel, dual-mode gradient, stability-indicating HPLC-DAD method for the simultaneous determination and purity assessment of mebeverine hydrochloride, diloxanide furoate and their corresponding major degradation products in combination with some gastrointestinal drugs in the form of oral doses.