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Sample records for stabilization equipment essential

  1. Characterization equipment essential drawing plan

    SciTech Connect

    WILSON, G.W.

    1999-05-14

    The purpose of this document is to list the Characterization equipment drawings that are classified as Essential Drawings and Support Drawings. Essential Drawings: Are those drawings identified by the facility staff as necessary to directly support the safe operation of the facility or equipment (HNF 1997a). Support Drawings: Are those drawings identified by facility staff that further describe the design details of structures, systems, or components shown on essential drawings. (HNF 1997a) The Characterization equipment drawings identified in this report are deemed essential drawings as defined in HNF-PRO-242, Engineering Drawing Requirements (HNF 1997a). These drawings will be prepared, revised, and maintained per HNF-PRO-440, Engineering Document Change Control (HNF 1997b). All other Characterization equipment drawings not identified in this document will be considered General drawings until the Characterization Equipment Drawing Evaluation Report (Wilson 1998) is updated during fiscal year 1999. Trucks 1 and 2 drawings are not included in this revision of the essential drawing list due to uncertainty about future use.

  2. Classroom Materials and Equipment--The Essentials.

    ERIC Educational Resources Information Center

    Texas Child Care, 1999

    1999-01-01

    Presents guidelines for buying classroom toys/equipment for child care settings. Lists examples of appropriate toys and equipment for infants, toddlers, preschoolers, and school-aged children in the following areas: action toys, art materials, audiovisual materials, balls, blocks and construction materials, books, discovery materials, dolls and…

  3. Test results: Halon 1301 versus water sprinkler fire protection for essential electronic equipment

    NASA Astrophysics Data System (ADS)

    Reichelt, E. F.; Walker, J. L.; Vickers, R. N.; Kwan, A. J.

    1982-07-01

    This report describes results of testing two contending extinguishants, Halon 1301 and water, for fire protection of essential electronic equipment. A series of controlled fires in a facility housing an operational electronic data processing system sought to establish immediate and long term effects of exposure of sensitive electronic equipment and stored data to fire extinguishment atmospheres. Test results lead to the conclusion that Halon 1301 is superior to water as an extinguishant for fires occurring in essential electronic equipment installations.

  4. Plutonium Finishing Plant (PFP) Stabilization & Packaging Equipment Hazard Analysis

    SciTech Connect

    BRAUN, D.J.

    2001-08-10

    A hazard analysis was performed to identify and evaluate hazards associated with the installation and subsequent operation of the Plutonium Stabilization and Packaging Equipment (SPE) at the Plutonium Finishing Plant (PFP). The SPE is designed to handle the packaging of Pu oxide, mixed Pu-uranium oxides, and Pu metals. This document provides the methodology used in the hazard analysis and the corresponding results. The Hazards and Operability Study (HazOp) technique was used in identifying the hazards associated with the SPE. The scope of the HazOp includes transporting the PFP convenience cans from the storage vaults to the SPE room, preparing and packaging of the material into 3013 packages using the SPE, and transport of the 3013 packages to the non-destructive analysis (NDA) lab or storage vault. The HazOp analysis also included construction activities associated with the modifications of the support utilities for the SPE, and the installation of support trailers.

  5. Fission yeast Sap1 protein is essential for chromosome stability.

    PubMed

    de Lahondès, Raynald; Ribes, Veronique; Arcangioli, Benoit

    2003-10-01

    Sap1 is a dimeric sequence-specific DNA binding-protein, initially identified for its role in mating-type switching of the fission yeast Schizosaccharomyces pombe. The protein is relatively abundant, around 10,000 dimers/cell, and is localized in the nucleus. sap1+ is essential for viability, and transient overexpression is accompanied by rapid cell death, without an apparent checkpoint response and independently of mating-type switching. Time lapse video microscopy of living cells revealed that the loss of viability is accompanied by abnormal mitosis and chromosome fragmentation. Overexpression of the C terminus of Sap1 induces minichromosome loss associated with the "cut" phenotype (uncoupling mitosis and cytokinesis). These phenotypes are favored when the C terminus of Sap1 is overexpressed during DNA replication. Fluorescence in situ hybridization experiments demonstrated that the cut phenotype is related to precocious centromere separation, a typical marker for loss of cohesion. We propose that Sap1 is an architectural chromatin-associated protein, required for chromosome organization. PMID:14555473

  6. Stability of the Martian atmosphere: Is heterogeneous catalysis essential?

    NASA Technical Reports Server (NTRS)

    Atreya, Sushil K.; Gu, Zhen Gang

    1994-01-01

    A comprehensive homogeneous gas phase photochemical model is developed to study the problem of stability of the Martian atmosphere. The one-dimensional model extends from the ground up to 220 km, passing through the homopause at 125 km. The model thus couples the lower (neutral) atmosphere to the ionosphere above which provides significant downward flux of carbon monoxide and oxygen atoms. It is concluded on the basic of currently accepted values for globally and seasonally averaged water vapor abundance, dust opacity and the middle atmospheric eddy mixing coefficient, as well as the relevant laboratory data (particularly the temperature dependence of CO2 absorption cross section and the rate constant for CO+OH reaction), that the rate of re-formation of carbon dioxide exceeds its photolytic destruction rate by about 40%. Furthermore, it is found that this result is virtually independent of the choice of eddy mixing coefficient, unless its value in the middle atmosphere exceeds 10(exp 8) sq cm/sec or is far smaller than 10(exp 5)sq cm/sec, or the dust opacity, unless it exceeds unity, or the water vapor mixing ratio at the surface, unless it is far smaller (less than or = 1 ppm) or far greater (greater than or = 500 ppm) than the average value (approximately 150 ppm). Since none of these extremes represent globally and seasonally averaged conditions on Mars, we propose that the present model requires existence of a mechanism to throttle down the recycling rate of carbon dioxide on Mars. Therefore, it is suggested that a heterogeneous process which provides a sink to the species that participate in the recycling of CO2, i.e., H2O, H2O2, OH, CO or O, in particular, may be necessary to bring about the balance between the CO2 recycling rate and its photolytic destruction rate. Aerosols of dust or ice (pure or doped water or carbon dioxide ice present in the atmosphere of Mars) can provide the appropriate adsorption sites for the above heterogeneous process. Despite our conclusion that some heterogeneous process may be needed, it is important to recognize that one-dimensional models can only provide first-order results which, most likely, represent globally and seasonally averaged conditions. However, it is only after actual temporal, latitudinal and longitudinal variations of relevant atmospheric parameters are included in the model that one can determine fuly whether the problem of atmospheric stabiltiy still continues to persist and whether some heterogeneous process is required to correct it.

  7. SLOPE STABILITY EVALUATION AND EQUIPMENT SETBACK DISTANCES FOR BURIAL GROUND EXCAVATIONS

    SciTech Connect

    MCSHANE DS

    2010-03-25

    After 1970 Transuranic (TRU) and suspect TRU waste was buried in the ground with the intention that at some later date the waste would be retrieved and processed into a configuration for long term storage. To retrieve this waste the soil must be removed (excavated). Sloping the bank of the excavation is the method used to keep the excavation from collapsing and to provide protection for workers retrieving the waste. The purpose of this paper is to document the minimum distance (setback) that equipment must stay from the edge of the excavation to maintain a stable slope. This evaluation examines the equipment setback distance by dividing the equipment into two categories, (1) equipment used for excavation and (2) equipment used for retrieval. The section on excavation equipment will also discuss techniques used for excavation including the process of benching. Calculations 122633-C-004, 'Slope Stability Analysis' (Attachment A), and 300013-C-001, 'Crane Stability Analysis' (Attachment B), have been prepared to support this evaluation. As shown in the calculations the soil has the following properties: Unit weight 110 pounds per cubic foot; and Friction Angle (natural angle of repose) 38{sup o} or 1.28 horizontal to 1 vertical. Setback distances are measured from the top edge of the slope to the wheels/tracks of the vehicles and heavy equipment being utilized. The computer program utilized in the calculation uses the center of the wheel or track load for the analysis and this difference is accounted for in this evaluation.

  8. Equipment

    NASA Astrophysics Data System (ADS)

    Szumski, Michał

    This chapter describes the most important features of capillary electrophoretic equipment. A presentation of the important developments in high voltage power supplies for chip CE is followed by preparation of fused silica capillaries for use in CE. Detection systems that are used in capillary electrophoresis are widely described. Here, UV-Vis absorbance measurements are discussed including different types of detection cells—also those less popular (u-shaped, Z-shaped, mirror-coated). Fluorescence detection and laser-induced fluorescence detection are the most sensitive detection systems. Several LIF setups, such as collinear, orthogonal, confocal, and sheath-flow cuvette, are presented from the point of view of the sensitivity they can provide. Several electrochemical detectors for CE, such as conductivity, amperometric, and potentiometric, are also shown and their constructions discussed. CE-MS and much less known CE (CEC)-NMR systems are also described. The examples of automation and robotized CE systems together with their potential fields of application are also presented.

  9. DEVELOPMENT OF EQUIPMENT FOR THE RETRIEVAL & STABILIZATION & ENCAPSULATION OF RADIOACTIVE SLUDGE AT THE HANFORD SITE

    SciTech Connect

    ROOSENDAAL, G.D.

    2005-07-05

    This poster presentation describes and illustrates some of the equipment and tools that Fluor Hanford and BNG America have developed and designed to remove, transport, stabilize and encapsulate radioactive sludge from the K Basins at the Hanford nuclear site in Washington State, U.S.A. K Basins were built in the early 1950s to temporarily store irradiated nuclear fuel prior to chemical processing to remove plutonium for nuclear weapons. The sludge is the result of corrosion of these fuel elements and its removal is the final stage before the basin water can be drained and the basins decommissioned. The sludge is hydrogen-generating because of its uranium metal content and account has to be taken also of its heat generating capacity and criticality potential as it is moved from one containment to another. The paper describes all stages of sludge treatment from the use of vacuum wands to suck up the sludge, through consolidating the sludge in temporary underwater containers, transporting it though flexible, temporary pipe systems, acceleration of the corrosion of uranium to reduce hydrogen generation, measuring the fissile content and finally encapsulation in a cement grout. Emphasis is placed on the use of existing, transportable and temporary equipment. This not only saves initial costs but it also reduces the total amount of equipment needed to be disposed of as radioactive waste at the end of the job. The processes, equipment and tools described potentially have a broad applicability to nuclear site decommissioning and cleanup worldwide.

  10. Thermal and oxidative stability of the Ocimum basilicum L. essential oil/β-cyclodextrin supramolecular system

    PubMed Central

    Hădărugă, Nicoleta G; Costescu, Corina I; David, Ioan; Gruia, Alexandra T

    2014-01-01

    Summary Ocimum basilicum L. essential oil and its β-cyclodextrin (β-CD) complex have been investigated with respect to their stability against the degradative action of air/oxygen and temperature. This supramolecular system was obtained by a crystallization method in order to achieve the equilibrium of complexed–uncomplexed volatile compounds in an ethanol/water solution at 50 °C. Both the raw essential oil and its β-CD complex have been subjected to thermal and oxidative degradation conditions in order to evaluate the protective capacity of β-CD. The relative concentration of the O. basilicum L. essential oil compounds, as determined by GC–MS, varies accordingly with their sensitivity to the thermal and/or oxidative degradation conditions imposed. Furthermore, the relative concentration of the volatile O. basilicum L. compounds found in the β-CD complex is quite different in comparison with the raw material. An increase of the relative concentration of linalool oxide from 0.3% to 1.1%, in addition to many sesquiterpene oxides, has been observed. β-CD complexation of the O. basilicum essential oil modifies the relative concentration of the encapsulated volatile compounds. Thus, linalool was better encapsulated in β-CD, while methylchavicol (estragole) was encapsulated in β-CD at a concentration close to that of the raw essential oil. Higher relative concentrations from the degradation of the oxygenated compounds such as linalool oxide and aromadendren oxide were determined in the raw O. basilicum L. essential oil in comparison with the corresponding β-CD complex. For the first time, the protective capability of natural β-CD for labile basil essential oil compounds has been demonstrated. PMID:25550747

  11. YsxC, an essential protein in Staphylococcus aureus crucial for ribosome assembly/stability

    PubMed Central

    2009-01-01

    Background Bacterial growth and division requires a core set of essential proteins, several of which are still of unknown function. They are also attractive targets for the development of new antibiotics. YsxC is a member of a family of GTPases highly conserved across eubacteria with a possible ribosome associated function. Results Here, we demonstrate by the creation of a conditional lethal mutant that ysxC is apparently essential for growth in S. aureus. To begin to elucidate YsxC function, a translational fusion of YsxC to the CBP-ProteinA tag in the staphylococcal chromosome was made, enabling Tandem Affinity Purification (TAP) of YsxC-interacting partners. These included the ribosomal proteins S2, S10 and L17, as well as the β' subunit of the RNA polymerase. YsxC was then shown to copurify with ribosomes as an accessory protein specifically localizing to the 50 S subunit. YsxC depletion led to a decrease in the presence of mature ribosomes, indicating a role in ribosome assembly and/or stability in S. aureus. Conclusions In this study we demonstrate that YsxC of S. aureus localizes to the ribosomes, is crucial for ribosomal stability and is apparently essential for the life of S. aureus. PMID:20021644

  12. Stability of nonfouling electroless nickel-polytetrafluoroethylene coatings after exposure to commercial dairy equipment sanitizers.

    PubMed

    Huang, Kang; Goddard, Julie M

    2015-09-01

    Application of nonfouling coatings on thermal processing equipment can improve operational efficiency. However, to enable effective commercial translation, a need exists for more comprehensive studies on the stability of nonfouling coatings after exposure to different sanitizers. In the current study, the influence of different commercial dairy equipment sanitizers on the nonfouling properties of stainless steel modified with electroless Ni-polytetrafluoroethylene (PTFE) coatings was determined. Surface properties, such as dynamic contact angle, surface energy, surface morphology, and elemental composition, were measured before and after the coupons were exposed to the sanitizers for 168 cleaning cycles. The fouling behavior of Ni-PTFE-modified stainless steel coupons after exposure was also evaluated by processing raw milk on a self-fabricated benchtop-scale plate heat exchanger. The results indicated that peroxide sanitizer had only minor effect on the Ni-PTFE-modified stainless steel surface, whereas chlorine- and iodine-based sanitizers influenced the surface properties drastically. The coupons after 168 cycles of exposure to peroxide sanitizer accumulated the least amount of fouling material (4.44±0.24mg/cm(2)) compared with the coupons exposed to the other 3 sanitizers. These observations indicated that the Ni-PTFE nonfouling coating retained antifouling properties after 168 cycles of exposure to peroxide-based sanitizer, supporting their potential application as nonfouling coatings for stainless steel dairy processing equipment. PMID:26142857

  13. Sde2: A novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe

    SciTech Connect

    Sugioka-Sugiyama, Rie; Initiative for the Promotion of Young Scientists' Independent Research, University of Tsukuba, Tsukuba, Ibaraki 305-8577 ; Sugiyama, Tomoyasu; Initiative for the Promotion of Young Scientists' Independent Research, University of Tsukuba, Tsukuba, Ibaraki 305-8577; Precursory Research for Embryonic Science and Technology , Japan Science and Technology Agency , Kawaguchi, Saitama 332-0012

    2011-03-18

    Research highlights: {yields} Sde2 is essential for telomere silencing. {yields} Sde2 is involved in the maintenance of genomic stability. {yields} Sde2 promotes the recruitment of SHREC, a histone deacetylase complex, to telomeres. -- Abstract: Telomeres, specialized domains assembled at the ends of linear chromosomes, are essential for genomic stability in eukaryotes. The formation and maintenance of telomeres are governed by numerous factors such as telomeric repeats, telomere-binding proteins, heterochromatin proteins, and telomerase. Here, we report Sde2, a novel nuclear protein essential for telomeric silencing and genomic stability in the fission yeast Schizosaccharomyces pombe. A deficiency in sde2 results in the derepression of the ura4{sup +} gene inserted near telomeric repeats, and the noncoding transcripts from telomeric regions accumulate in sde2{Delta} cells. The loss of Sde2 function compromises transcriptional silencing at telomeres, and this silencing defect is accompanied by increased levels of acetylated histone H3K14 and RNA polymerase II occupancy at telomeres as well as reduced recruitment of the SNF2 ATPase/histone deacetylase-containing complex SHREC to telomeres. Deletion of sde2 also leads to a higher frequency of mitotic minichromosome loss, and sde2{Delta} cells often form asci that contain spores in abnormal numbers, shapes, or both. In addition, sde2{Delta} cells are highly sensitive to several stresses, including high/low temperatures, bleomycin, which induces DNA damage, and thiabendazole, a microtubule-destabilizing agent. Furthermore, Sde2 genetically interacts with the telomere regulators Taz1, Pof3, and Ccq1. These findings demonstrate that Sde2 cooperates with other telomere regulators to maintain functional telomeres, thereby preventing genomic instability.

  14. Essential role of Pin1 in regulation of TRF1 stability and telomere maintenance

    PubMed Central

    Lee, Tae Ho; Tun-Kyi, Adrian; Shi, Rong; Lim, Jormay; Soohoo, Christina; Finn, Greg; Balastik, Martin; Pastorino, Lucia; Wulf, Gerburg; Zhou, Xiao Zhen; Lu, Kun Ping

    2009-01-01

    Telomeres are essential for maintaining cellular proliferative capacity and their loss has been implicated in aging. A key regulator in telomere maintenance is the telomeric protein TRF1, which was also identified as Pin2 in a same screen for Pin1. Pin1 is a unique prolyl isomerase that regulates protein conformation and function after phosphorylation. However, little is known about the role of Pin1 in telomere regulation and the modulation of TRF1 by upstream signals. Here we identify TRF1 as a major conserved substrate for Pin1 during telomere maintenance and aging. Pin1 inhibition renders TRF1 resistant to protein degradation, enhances TRF1 binding on telomeres, and leads to gradual telomere loss in human cells and in mice. Pin1-deficient mice also display widespread premature aging phenotypes within just one generation similar to those in telomerase-deficient mice after 4–5 consecutive generations. Thus, Pin1 is an essential novel regulator of TRF1 stability, telomere maintenance and aging. PMID:19060891

  15. Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity

    PubMed Central

    Mahuzier, Alexia; Gaudé, Helori-Mael; Grampa, Valentina; Anselme, Isabelle; Silbermann, Flora; Leroux-Berger, Margot; Delacour, Delphine; Ezan, Jerome; Montcouquiol, Mireille; Saunier, Sophie

    2012-01-01

    Cilia are at the core of planar polarity cellular events in many systems. However, the molecular mechanisms by which they influence the polarization process are unclear. Here, we identify the function of the ciliopathy protein Rpgrip1l in planar polarity. In the mouse cochlea and in the zebrafish floor plate, Rpgrip1l was required for positioning the basal body along the planar polarity axis. Rpgrip1l was also essential for stabilizing dishevelled at the cilium base in the zebrafish floor plate and in mammalian renal cells. In rescue experiments, we showed that in the zebrafish floor plate the function of Rpgrip1l in planar polarity was mediated by dishevelled stabilization. In cultured cells, Rpgrip1l participated in a complex with inversin and nephrocystin-4, two ciliopathy proteins known to target dishevelled to the proteasome, and, in this complex, Rpgrip1l prevented dishevelled degradation. We thus uncover a ciliopathy protein complex that finely tunes dishevelled levels, thereby modulating planar cell polarity processes. PMID:22927466

  16. Hybrid nanomaterial for stabilizing the antibiofilm activity of Eugenia carryophyllata essential oil.

    PubMed

    Grumezescu, Alexandru Mihai; Chifiriuc, Mariana Carmen; Saviuc, Crina; Grumezescu, Valentina; Hristu, Radu; Mihaiescu, Dan Eduard; Stanciu, George A; Andronescu, Ecaterina

    2012-12-01

    The aim of the present study was to demonstrate that Fe(3)O(4)/oleic acid core/shell nanostructures could be used as systems for stabilizing the Eugenia carryophyllata essential oil (EO) on catheter surface pellicles, in order to improve their resistance to fungal colonization. EO microwave assisted extraction was performed in a Neo-Clevenger (related) device and its chemical composition was settled by GC-MS analysis. Fe(3)O(4)/oleic acid-core/shell nanoparticles (NP) were obtained by a precipitation method under microwave condition. High resolution transmission electron microscopy (HR-TEM) was used as a primary characterization method. The NPs were processed to achieve a core/shell/EO coated-shell nanosystem further used for coating the inner surface of central venous catheter samples. The tested fungal strains have been recently isolated from different clinical specimens. The biofilm architecture was assessed by confocal laser scanning microscopy (CLSM). Our results claim the usage of hybrid nanomaterial (core/shell/coated-shell) for the stabilization of E. carryophyllata EO, which prevented or inhibited the fungal biofilm development on the functionalized catheter, highlighting the opportunity of using these nanosystems to obtain improved, anti-biofilm coatings for biomedical applications. PMID:22949098

  17. Human single-stranded DNA binding proteins are essential for maintaining genomic stability

    PubMed Central

    2013-01-01

    The double-stranded conformation of cellular DNA is a central aspect of DNA stabilisation and protection. The helix preserves the genetic code against chemical and enzymatic degradation, metabolic activation, and formation of secondary structures. However, there are various instances where single-stranded DNA is exposed, such as during replication or transcription, in the synthesis of chromosome ends, and following DNA damage. In these instances, single-stranded DNA binding proteins are essential for the sequestration and processing of single-stranded DNA. In order to bind single-stranded DNA, these proteins utilise a characteristic and evolutionary conserved single-stranded DNA-binding domain, the oligonucleotide/oligosaccharide-binding (OB)-fold. In the current review we discuss a subset of these proteins involved in the direct maintenance of genomic stability, an important cellular process in the conservation of cellular viability and prevention of malignant transformation. We discuss the central roles of single-stranded DNA binding proteins from the OB-fold domain family in DNA replication, the restart of stalled replication forks, DNA damage repair, cell cycle-checkpoint activation, and telomere maintenance. PMID:23548139

  18. Evaluation of thermal-oxidative stability and antiglioma activity of Zanthoxylum tingoassuiba essential oil entrapped into multi- and unilamellar liposomes.

    PubMed

    Detoni, Cassia B; de Oliveira, Diêgo Madureira; Santo, Islane E; Pedro, André São; El-Bacha, Ramon; da Silva Velozo, Eudes; Ferreira, Domingos; Sarmento, Bruno; de Magalhães Cabral-Albuquerque, Elaine C

    2012-03-01

    Zanthoxylum tinguassuiba essential oil (ZtEO) contains α-bisabolol, a known antiglioma sesquiterpene, among other potentially active substances. Medical applications of this essential oil require advances in the design of distinctive carriers due to its low water solubility and easy degradation by heat, light, and oxygen. The aim of this work was to evaluate enhancement in oxidative stability and the ability to reduce glioblastoma cell viability of ZtEO loaded into liposomes. Multi- and unilamellar vesicles were prepared to carry ZtEO. By using thermal analysis, it was observed that thermal-oxidative stability of the liposomal ZtEO was enhanced, when compared to its free form. Liposomal ZtEO also presented significant apoptotic-inducing activity for glioma cells. These results show that liposomal systems carrying ZtEO may be a potential alternative for gliobastoma treatment. PMID:21548711

  19. Coaxial type of self-mixing interferometer equipped with a wavelength stabilizing system

    NASA Astrophysics Data System (ADS)

    Suzuki, Takamasa; Irisawa, Tsutomu; Yokoyama, Kazuhiro; Sasaki, Osami

    2002-06-01

    Because the wavelength of a laser diode (LD) has the temperature-sensitivity, in conventional LD interferometers, a temperature control is required to stabilize the wavelength in long-term measurements. We propose a self-mixing laser diode interferometer that has two coaxial measurement arms. Two interference signals are used for the measurement of displacement and wavelength stabilization in our system. As the wavelength is not stabilized thermostatically, but by adjusting current feedback, compensation is simple and response-time minimal. The feedback controls for displacement measurement and wavelength stabilization were implemented on a time-sharing basis. The devise we propose enables us to conduct long-term measurements of microscopic levels of displacement.

  20. Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells

    PubMed Central

    Muharram, Ghaffar; Sahgal, Pranshu; Korpela, Taina; De Franceschi, Nicola; Kaukonen, Riina; Clark, Katherine; Tulasne, David; Carpén, Olli; Ivaska, Johanna

    2014-01-01

    Summary Inappropriate MET tyrosine kinase receptor signaling is detected in almost all types of human cancer and contributes to malignant growth and MET dependency via proliferative and antiapoptotic activities. Independently, Tensin-4 (TNS4) is emerging as a putative oncogene in many cancer types, but the mechanisms of TNS4 oncogenic activity are not well established. Here, we demonstrate that TNS4 directly interacts with phosphorylated MET via the TNS4 SH2-domain to positively regulate cell survival, proliferation, and migration, through increased MET protein stability. In addition, TNS4 interaction with β1-integrin cytoplasmic tail positively regulates β1-integrin stability. Loss of TNS4 or disruption of MET-TNS4 interaction triggers MET trafficking toward the lysosomal compartment that is associated with excessive degradation of MET and triggers MET-addicted carcinoma cell death in vitro and in vivo. Significant correlation between MET and TNS4 expression in human colon carcinoma and ovarian carcinoma suggests TNS4 plays a critical role in MET stability in cancer. PMID:24814316

  1. The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability

    PubMed Central

    Yankiwski, Victor; Noonan, James P; Neff, Norma F

    2001-01-01

    Background Bloom syndrome is a rare cancer-prone disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability. Bloom syndrome cells have a distinctive high frequency of sister chromatid exchange and quadriradial formation. BLM, the protein altered in BS, is a member of the RecQ DNA helicase family, whose members share an average of 40% identity in the helicase domain and have divergent N-terminal and C-terminal flanking regions of variable lengths. The BLM DNA helicase has been shown to localize to the ND10 (nuclear domain 10) or PML (promyelocytic leukemia) nuclear bodies, where it associates with TOPIIIα, and to the nucleolus. Results This report demonstrates that the N-terminal domain of BLM is responsible for localization of the protein to the nuclear bodies, while the C-terminal domain directs the protein to the nucleolus. Deletions of the N-terminal domain of BLM have little effect on sister chromatid exchange frequency and chromosome stability as compared to helicase and C-terminal mutations which can increase SCE frequency and chromosome abnormalities. Conclusion The helicase activity and the C-terminal domain of BLM are critical for maintaining genomic stability as measured by the sister chromatid exchange assay. The localization of BLM into the nucleolus by the C-terminal domain appears to be more important to genomic stability than localization in the nuclear bodies. PMID:11472631

  2. USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.

    PubMed

    Zlatanou, A; Sabbioneda, S; Miller, E S; Greenwalt, A; Aggathanggelou, A; Maurice, M M; Lehmann, A R; Stankovic, T; Reverdy, C; Colland, F; Vaziri, C; Stewart, G S

    2016-02-25

    Rad18 functions at the cross-roads of three different DNA damage response (DDR) pathways involved in protecting stressed replication forks: homologous recombination repair, DNA inter-strand cross-link repair and DNA damage tolerance. Although Rad18 serves to facilitate replication of damaged genomes by promoting translesion synthesis (TLS), this comes at a cost of potentially error-prone lesion bypass. In contrast, loss of Rad18-dependent TLS potentiates the collapse of stalled forks and leads to incomplete genome replication. Given the pivotal nature with which Rad18 governs the fine balance between replication fidelity and genome stability, Rad18 levels and activity have a major impact on genomic integrity. Here, we identify the de-ubiquitylating enzyme USP7 as a critical regulator of Rad18 protein levels. Loss of USP7 destabilizes Rad18 and compromises UV-induced PCNA mono-ubiquitylation and Pol η recruitment to stalled replication forks. USP7-depleted cells also fail to elongate nascent daughter strand DNA following UV irradiation and show reduced DNA damage tolerance. We demonstrate that USP7 associates with Rad18 directly via a consensus USP7-binding motif and can disassemble Rad18-dependent poly-ubiquitin chains both in vitro and in vivo. Taken together, these observations identify USP7 as a novel component of the cellular DDR involved in preserving the genome stability. PMID:25961918

  3. A mammalian NudC-like protein essential for dynein stability and cell viability

    PubMed Central

    Zhou, Tianhua; Zimmerman, Wendy; Liu, Xiaoqi; Erikson, Raymond L.

    2006-01-01

    Cytoplasmic dynein, a minus-end-directed microtubule motor, has been implicated in many fundamental cellular processes; however, little is known regarding the underlying molecular machinery that regulates its stability. In Aspergillus nidulans, nuclear distribution gene C (nudC) has been implicated in the regulation of dynein-mediated nuclear migration. Here, we characterize a previously undescribed mammalian NudC-like protein (NudCL). The expression and phosphorylation of NudCL are increased during mitosis. Depletion of NudCL by RNA interference in HeLa cells inhibits cell growth and induces mitotic arrest with multiple mitotic defects, which subsequently result in cell death. Unexpectedly, the majority of NudCL depletion-induced mitotic defects may result from loss of dynein function; this interpretation is supported by the failure to recruit sufficient γ-tubulin to spindle poles and the mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles during mitosis. Depletion of NudCL also results in the aggregation of dynein intermediate chain throughout the cytoplasm during mitosis. NudCL was shown to bind to the dynein complex, and its depletion induces degradation of dynein intermediate chain, a process suppressed by MG132, a proteasome inhibitor. Taken together, these data suggest a previously undescribed mechanism whereby NudCL appears to influence the stabilization of dynein intermediate chain. PMID:16754861

  4. Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells.

    PubMed

    Groth-Pedersen, Line; Aits, Sonja; Corcelle-Termeau, Elisabeth; Petersen, Nikolaj H T; Nylandsted, Jesper; Jäättelä, Marja

    2012-01-01

    Microtubule-disturbing drugs inhibit lysosomal trafficking and induce lysosomal membrane permeabilization followed by cathepsin-dependent cell death. To identify specific trafficking-related proteins that control cell survival and lysosomal stability, we screened a molecular motor siRNA library in human MCF7 breast cancer cells. SiRNAs targeting four kinesins (KIF11/Eg5, KIF20A, KIF21A, KIF25), myosin 1G (MYO1G), myosin heavy chain 1 (MYH1) and tropomyosin 2 (TPM2) were identified as effective inducers of non-apoptotic cell death. The cell death induced by KIF11, KIF21A, KIF25, MYH1 or TPM2 siRNAs was preceded by lysosomal membrane permeabilization, and all identified siRNAs induced several changes in the endo-lysosomal compartment, i.e. increased lysosomal volume (KIF11, KIF20A, KIF25, MYO1G, MYH1), increased cysteine cathepsin activity (KIF20A, KIF25), altered lysosomal localization (KIF25, MYH1, TPM2), increased dextran accumulation (KIF20A), or reduced autophagic flux (MYO1G, MYH1). Importantly, all seven siRNAs also killed human cervix cancer (HeLa) and osteosarcoma (U-2-OS) cells and sensitized cancer cells to other lysosome-destabilizing treatments, i.e. photo-oxidation, siramesine, etoposide or cisplatin. Similarly to KIF11 siRNA, the KIF11 inhibitor monastrol induced lysosomal membrane permeabilization and sensitized several cancer cell lines to siramesine. While KIF11 inhibitors are under clinical development as mitotic blockers, our data reveal a new function for KIF11 in controlling lysosomal stability and introduce six other molecular motors as putative cancer drug targets. PMID:23071517

  5. Operational stability of rubidium and cesium frequency standards. [analysis of equipment performance at NASA tracking stations

    NASA Technical Reports Server (NTRS)

    Lavery, J. E.

    1972-01-01

    In the course of testing various rubidium and cesium frequency standards under operational conditions for use in NASA tracking stations, about 55 unit-years of relative frequency measurements for averaging times from 10 to 10 to the 7th power have been accumulated at Goddard Space Flight Center (GSFC). Statistics on the behavior of rubidium and cesium standards under controlled laboratory conditions have been published, but it was not known to what extent the lesser controlled environments of NASA tracking stations affected the performance of the standards. The purpose of this report is to present estimates of the frequency stability of rubidium and cesium frequency standards under operational conditions based on the data accumulated at GSFC.

  6. Enhancing stability of essential oils by microencapsulation for preservation of button mushroom during postharvest

    PubMed Central

    Alikhani-Koupaei, Majid; Mazlumzadeh, Meisam; Sharifani, Mohamadmehdi; Adibian, Mohamad

    2014-01-01

    Fresh button mushrooms (Agaricus bisporus L.) are sensitive to browning, water loss, and microbial attack. The short shelf-life of mushrooms is an impediment to the distribution and marketing of the fresh product. Essential oils outstand as an alternative to chemical preservatives and their use in foods meets the demands of consumers for natural products. To resolve controlled release of oil and increase in antioxidant and antimicrobial activities, the oil was incorporated into microcapsules. Effects of microcapsulated thyme (Thymus vulgaris L.) and rosemary (Rosmarinus officinalis L.) on quality of fresh button mushroom were compared. Physicochemical qualities were evaluated during 15 days of storage at 4 ± 0.5°C. All treatments prevented product weight loss and decrease in polyphenoloxidase and peroxidase activities during storage. Color and firmness, microbiological analysis, and total phenolic content caused the least change. With use of microencapsulated oils, mushrooms were within acceptable limits during 10 days of storage. Microencapsulated rosemary oil produced the highest beneficial effects and has potential to improve quality of button mushrooms and extend shelf-life. PMID:25473510

  7. Enhancing stability of essential oils by microencapsulation for preservation of button mushroom during postharvest.

    PubMed

    Alikhani-Koupaei, Majid; Mazlumzadeh, Meisam; Sharifani, Mohamadmehdi; Adibian, Mohamad

    2014-09-01

    Fresh button mushrooms (Agaricus bisporus L.) are sensitive to browning, water loss, and microbial attack. The short shelf-life of mushrooms is an impediment to the distribution and marketing of the fresh product. Essential oils outstand as an alternative to chemical preservatives and their use in foods meets the demands of consumers for natural products. To resolve controlled release of oil and increase in antioxidant and antimicrobial activities, the oil was incorporated into microcapsules. Effects of microcapsulated thyme (Thymus vulgaris L.) and rosemary (Rosmarinus officinalis L.) on quality of fresh button mushroom were compared. Physicochemical qualities were evaluated during 15 days of storage at 4 ± 0.5°C. All treatments prevented product weight loss and decrease in polyphenoloxidase and peroxidase activities during storage. Color and firmness, microbiological analysis, and total phenolic content caused the least change. With use of microencapsulated oils, mushrooms were within acceptable limits during 10 days of storage. Microencapsulated rosemary oil produced the highest beneficial effects and has potential to improve quality of button mushrooms and extend shelf-life. PMID:25473510

  8. Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth.

    PubMed

    Koo, Yeon; Barry, David M; Xu, Ke; Tanigaki, Keiji; Davis, George E; Mineo, Chieko; Cleaver, Ondine

    2016-04-01

    Cardiovascular function depends on patent, continuous and stable blood vessel formation by endothelial cells (ECs). Blood vessel development initiates by vasculogenesis, as ECs coalesce into linear aggregates and organize to form central lumens that allow blood flow. Molecular mechanisms underlying in vivo vascular 'tubulogenesis' are only beginning to be unraveled. We previously showed that the GTPase-interacting protein called Rasip1 is required for the formation of continuous vascular lumens in the early embryo. Rasip1(-/-) ECs exhibit loss of proper cell polarity and cell shape, disrupted localization of EC-EC junctions and defects in adhesion of ECs to extracellular matrix. In vitro studies showed that Rasip1 depletion in cultured ECs blocked tubulogenesis. Whether Rasip1 is required in blood vessels after their initial formation remained unclear. Here, we show that Rasip1 is essential for vessel formation and maintenance in the embryo, but not in quiescent adult vessels. Rasip1 is also required for angiogenesis in three models of blood vessel growth: in vitro matrix invasion, retinal blood vessel growth and directed in vivo angiogenesis assays. Rasip1 is thus necessary in growing embryonic blood vessels, postnatal angiogenic sprouting and remodeling, but is dispensable for maintenance of established blood vessels, making it a potential anti-angiogenic therapeutic target. PMID:26897025

  9. Cdk12 is essential for embryonic development and the maintenance of genomic stability.

    PubMed

    Juan, H-C; Lin, Y; Chen, H-R; Fann, M-J

    2016-06-01

    The maintenance of genomic integrity during early embryonic development is important in order to ensure the proper development of the embryo. Studies from cultured cells have demonstrated that cyclin-dependent kinase 12 (Cdk12) is a multifunctional protein that maintains genomic stability and the pluripotency of embryonic stem cells. Perturbation of its functions is also known to be associated with pathogenesis and drug resistance in human cancers. However, the biological significance of Cdk12 in vivo is unclear. Here we bred mice that are deficient in Cdk12 and demonstrated that Cdk12 depletion leads to embryonic lethality shortly after implantation. We also used an in vitro culture system of blastocysts to examine the molecular mechanisms associated with the embryonic lethality of Cdk12-deficient embryos. Cdk12(-/-) blastocysts fail to undergo outgrowth of the inner cell mass because of an increase in the apoptosis of these cells. Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos. Furthermore, the expression levels of various DNA damage response genes, namely Atr, Brca1, Fanci and Fancd2, are reduced in Cdk12(-/-) embryos. These findings indicate that Cdk12 is important for the correct expression of some DNA damage response genes and indirectly has an influence on the efficiency of DNA repair. Our report also highlights that DNA breaks occurring during DNA replication are frequent in mouse embryonic cells and repair of such damage is critical to the successful development of mouse embryos. PMID:26658019

  10. The Effect of Oregano and Cinnamon Essential Oils on Fermentation Quality and Aerobic Stability of Field Pea Silages.

    PubMed

    Soycan-Önenç, Sibel; Koc, Fisun; Coşkuntuna, Levent; Özdüven, M Levent; Gümüş, Tuncay

    2015-09-01

    This study was performed to determine the effect of field pea silages which were the organic acid (OA) alternative of oregano and cinnamon essential oils on fermentation quality and aerobic stability. Whole crop pea was harvested at full pod stage and wilted in the laboratory at the 48 h. The chopped pea was mixed and divided into equal portions allocated to five groups: CON (non-treated), distilled water, denoted as control group; OA group, a mixture of 60% formic acid, 20% sodium formate and 20% water applied at a rate of 5 g/kg fresh forage (Silofarm Liquid, Farmavet); origanum (ORE) group, Origanum onites essential oil at 400 mg/kg fresh forage; cinnamon (CIN) group, cinnamon essential oil at 400 mg/kg fresh forage; origanum+cinnamon (ORECIN) group, a mixture of ORE and CIN applied at an equal rate of 400 mg/kg fresh forage. Cinnamon decreased acetic acid (AA), ammonia nitrogen (NH3-N) and weight loss (WL) at the end of 60 days silage. Crude protein (CP) and dry matter (DM) increased by cinnamon essential oil. Yeasts were not detected in any treatments, including the control, after 7 days of air exposure. The CO2 amount decreased and the formation mold was inhibited in the aerobic period by the addition of cinnamon oil. Oregano did not show a similar effect, but when it was used with cinnamon, it showed synergic effect on AA and during aerobic period, it showed antagonistic effect on mold formation and DM losses. It was found in this study that cinnamon can be an alternative to organic acids. PMID:26323518

  11. The Effect of Oregano and Cinnamon Essential Oils on Fermentation Quality and Aerobic Stability of Field Pea Silages

    PubMed Central

    Soycan-Önenç, Sibel; Koc, Fisun; Coşkuntuna, Levent; Özdüven, M. Levent; Gümüş, Tuncay

    2015-01-01

    This study was performed to determine the effect of field pea silages which were the organic acid (OA) alternative of oregano and cinnamon essential oils on fermentation quality and aerobic stability. Whole crop pea was harvested at full pod stage and wilted in the laboratory at the 48 h. The chopped pea was mixed and divided into equal portions allocated to five groups: CON (non-treated), distilled water, denoted as control group; OA group, a mixture of 60% formic acid, 20% sodium formate and 20% water applied at a rate of 5 g/kg fresh forage (Silofarm Liquid, Farmavet); origanum (ORE) group, Origanum onites essential oil at 400 mg/kg fresh forage; cinnamon (CIN) group, cinnamon essential oil at 400 mg/kg fresh forage; origanum+cinnamon (ORECIN) group, a mixture of ORE and CIN applied at an equal rate of 400 mg/kg fresh forage. Cinnamon decreased acetic acid (AA), ammonia nitrogen (NH3-N) and weight loss (WL) at the end of 60 days silage. Crude protein (CP) and dry matter (DM) increased by cinnamon essential oil. Yeasts were not detected in any treatments, including the control, after 7 days of air exposure. The CO2 amount decreased and the formation mold was inhibited in the aerobic period by the addition of cinnamon oil. Oregano did not show a similar effect, but when it was used with cinnamon, it showed synergic effect on AA and during aerobic period, it showed antagonistic effect on mold formation and DM losses. It was found in this study that cinnamon can be an alternative to organic acids. PMID:26323518

  12. Dynamic response and stability analysis of an unbalanced flexible rotating shaft equipped with n automatic ball-balancers

    NASA Astrophysics Data System (ADS)

    Ehyaei, J.; Moghaddam, Majid M.

    2009-04-01

    The paper presents analytical and numerical investigations of a system of unbalanced flexible rotating shaft equipped with n automatic ball-balancers, where the unbalanced masses are distributed in the length of the shaft. It includes the derivation of the equations of motion, the stability analysis on the basis of linearized equations of motion around the equilibrium position, and the results of the time responses of the system. The Stodola-Green rotor model, of which the shaft is assumed flexible, is proposed for the analysis step. The rotor model includes the influence of rigid-body rotations, due to the shaft flexibility. Utilizing Lagrange's method, the nonlinear equations of motion are derived. The study shows that for the angular velocities more than the first natural frequency and selecting the suitable values for the parameters of the automatic ball-balancers, which are in the stability region, the auto ball-balancers tend to improve the vibration behavior of the system, i.e., the partial balancing, but the complete balancing was achieved in a special case, where the imbalances are in the planes of the auto ball-balancers. Furthermore, it is shown that if the auto ball-balancers are closer to the unbalanced masses, a better vibration reduction is achieved.

  13. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.

    PubMed

    Zhou, Xiao Zhen; Huang, Pengyu; Shi, Rong; Lee, Tae Ho; Lu, Gina; Zhang, Zhihong; Bronson, Roderick; Lu, Kun Ping

    2011-04-01

    Telomerase is activated in most human cancers and is critical for cancer cell growth. However, little is known about the significance of telomerase activation in chromosome instability and cancer initiation. The gene encoding the potent endogenous telomerase inhibitor PinX1 (PIN2/TRF1-interacting, telomerase inhibitor 1) is located at human chromosome 8p23, a region frequently exhibiting heterozygosity in many common human cancers, but the function or functions of PinX1 in development and tumorigenesis are unknown. Here we have shown that PinX1 is a haploinsufficient tumor suppressor essential for chromosome stability in mice. We found that PinX1 expression was reduced in most human breast cancer tissues and cell lines. Furthermore, PinX1 heterozygosity and PinX1 knockdown in mouse embryonic fibroblasts activated telomerase and led to concomitant telomerase-dependent chromosomal instability. Moreover, while PinX1-null mice were embryonic lethal, most PinX1+/- mice spontaneously developed malignant tumors with evidence of chromosome instability. Notably, most PinX1 mutant tumors were carcinomas and shared tissues of origin with human cancer types linked to 8p23. PinX1 knockout also shifted the tumor spectrum of p53 mutant mice from lymphoma toward epithelial carcinomas. Thus, PinX1 is a major haploinsufficient tumor suppressor essential for maintaining telomerase activity and chromosome stability. These findings uncover what we believe to be a novel role for PinX1 and telomerase in chromosome instability and cancer initiation and suggest that telomerase inhibition may be potentially used to treat cancers that overexpress telomerase. PMID:21436583

  14. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice

    PubMed Central

    Zhou, Xiao Zhen; Huang, Pengyu; Shi, Rong; Lee, Tae Ho; Lu, Gina; Zhang, Zhihong; Bronson, Roderick; Lu, Kun Ping

    2011-01-01

    Telomerase is activated in most human cancers and is critical for cancer cell growth. However, little is known about the significance of telomerase activation in chromosome instability and cancer initiation. The gene encoding the potent endogenous telomerase inhibitor PinX1 (PIN2/TRF1-interacting, telomerase inhibitor 1) is located at human chromosome 8p23, a region frequently exhibiting heterozygosity in many common human cancers, but the function or functions of PinX1 in development and tumorigenesis are unknown. Here we have shown that PinX1 is a haploinsufficient tumor suppressor essential for chromosome stability in mice. We found that PinX1 expression was reduced in most human breast cancer tissues and cell lines. Furthermore, PinX1 heterozygosity and PinX1 knockdown in mouse embryonic fibroblasts activated telomerase and led to concomitant telomerase-dependent chromosomal instability. Moreover, while PinX1-null mice were embryonic lethal, most PinX1+/– mice spontaneously developed malignant tumors with evidence of chromosome instability. Notably, most PinX1 mutant tumors were carcinomas and shared tissues of origin with human cancer types linked to 8p23. PinX1 knockout also shifted the tumor spectrum of p53 mutant mice from lymphoma toward epithelial carcinomas. Thus, PinX1 is a major haploinsufficient tumor suppressor essential for maintaining telomerase activity and chromosome stability. These findings uncover what we believe to be a novel role for PinX1 and telomerase in chromosome instability and cancer initiation and suggest that telomerase inhibition may be potentially used to treat cancers that overexpress telomerase. PMID:21436583

  15. Retinoic Acid Is Essential for Th1 Cell Lineage Stability and Prevents Transition to a Th17 Cell Program

    PubMed Central

    Brown, Chrysothemis C.; Esterhazy, Daria; Sarde, Aurelien; London, Mariya; Pullabhatla, Venu; Osma-Garcia, Ines; al-Bader, Raya; Ortiz, Carla; Elgueta, Raul; Arno, Matthew; de Rinaldis, Emanuele; Mucida, Daniel; Lord, Graham M.; Noelle, Randolph J.

    2015-01-01

    Summary CD4+ T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4+ T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, the factors that regulate lineage stability are largely unknown. Here we investigate a role for retinoic acid (RA) in the regulation of lineage stability using T helper 1 (Th1) cells, traditionally considered the most phenotypically stable Th subset. We found that RA, through its receptor RARα, sustains stable expression of Th1 lineage specifying genes, as well as repressing genes that instruct Th17-cell fate. RA signaling is essential for limiting Th1-cell conversion into Th17 effectors and for preventing pathogenic Th17 responses in vivo. Our study identifies RA-RARα as a key component of the regulatory network governing maintenance and plasticity of Th1-cell fate and defines an additional pathway for the development of Th17 cells. PMID:25769610

  16. The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.

    PubMed

    Akiyama, Benjamin M; Parks, Joseph W; Stone, Michael D

    2015-06-23

    Telomerase is an enzyme that adds repetitive DNA sequences to the ends of chromosomes and consists of two main subunits: the telomerase reverse transcriptase (TERT) protein and an associated telomerase RNA (TER). The telomerase essential N-terminal (TEN) domain is a conserved region of TERT proposed to mediate DNA substrate interactions. Here, we have employed single molecule telomerase binding assays to investigate the function of the TEN domain. Our results reveal telomeric DNA substrates bound to telomerase exhibit a dynamic equilibrium between two states: a docked conformation and an alternative conformation. The relative stabilities of the docked and alternative states correlate with the number of basepairs that can be formed between the DNA substrate and the RNA template, with more basepairing favoring the docked state. The docked state is further buttressed by the TEN domain and mutations within the TEN domain substantially alter the DNA substrate structural equilibrium. We propose a model in which the TEN domain stabilizes short RNA-DNA duplexes in the active site of the enzyme, promoting the docked state to augment telomerase processivity. PMID:25940626

  17. Implementation of an ex situ stabilization technique at the Sand Springs superfund site to solidify and stabilize acid tar sludges involving a quick-lime based stabilization process and innovative equipment design

    SciTech Connect

    McManus, R.W.; Grajczak, P.; Wilcoxson, J.C.; Webster, S.D.

    1997-12-31

    An old refinery site was safely remediated a year before schedule and for 25% less than final engineering estimates for the stabilization remedy thanks to energetic project management and innovative design involving ex situ stabilization/solidification of acid tar sludges. A quicklime based process, Dispersion by Chemical Reaction (DCR{trademark}), was employed to solidify and stabilize (SS) over 103,000 cubic meters (135,000 cubic yards) of petroleum waste, mostly acidic tarry sludge. The SS process was selected over competing methods because it afforded minimal volume increase, could readily achieve Record of Decision (ROD) specified physical and chemical treatment goals, could be implemented with treatment equipment that minimized emissions, and could be performed with low reagent usage and at low cost. To ensure treatment goals were achieved and an accelerated schedule met, a custom designed and fabricated transportable treatment unit (TTU) was employed to implement the process. The treated material was visually soil-like in character, it was left in stockpiles for periods of time, and it was placed and compacted in the on site landfill using standard earth-moving equipment.

  18. Disulfide-Mediated Stabilization of the IκB Kinase Binding Domain of NF-κB Essential Modulator (NEMO)

    PubMed Central

    2015-01-01

    Human NEMO (NF-κB essential modulator) is a 419 residue scaffolding protein that, together with catalytic subunits IKKα and IKKβ, forms the IκB kinase (IKK) complex, a key regulator of NF-κB pathway signaling. NEMO is an elongated homodimer comprising mostly α-helix. It has been shown that a NEMO fragment spanning residues 44–111, which contains the IKKα/β binding site, is structurally disordered in the absence of bound IKKβ. Herein we show that enforcing dimerization of NEMO1–120 or NEMO44–111 constructs through introduction of one or two interchain disulfide bonds, through oxidation of the native Cys54 residue and/or at position 107 through a Leu107Cys mutation, induces a stable α-helical coiled-coil structure that is preorganized to bind IKKβ with high affinity. Chemical and thermal denaturation studies showed that, in the context of a covalent dimer, the ordered structure was stabilized relative to the denatured state by up to 3 kcal/mol. A full-length NEMO-L107C protein formed covalent dimers upon treatment of mammalian cells with H2O2. Furthermore, NEMO-L107C bound endogenous IKKβ in A293T cells, reconstituted TNF-induced NF-κB signaling in NEMO-deficient cells, and interacted with TRAF6. Our results indicate that the IKKβ binding domain of NEMO possesses an ordered structure in the unbound state, provided that it is constrained within a dimer as is the case in the constitutively dimeric full-length NEMO protein. The stability of the NEMO coiled coil is maintained by strong interhelix interactions in the region centered on residue 54. The disulfide-linked constructs we describe herein may be useful for crystallization of NEMO’s IKKβ binding domain in the absence of bound IKKβ, thereby facilitating the structural characterization of small-molecule inhibitors. PMID:25400026

  19. The Structure-Specific Endonucleases MUS81 and SEND1 Are Essential for Telomere Stability in Arabidopsis.

    PubMed

    Olivier, Margaux; Da Ines, Olivier; Amiard, Simon; Serra, Heïdi; Goubely, Chantal; White, Charles I; Gallego, Maria E

    2016-01-01

    Structure-specific endonucleases act to repair potentially toxic structures produced by recombination and DNA replication, ensuring proper segregation of the genetic material to daughter cells during mitosis and meiosis. Arabidopsis thaliana has two putative homologs of the resolvase (structure-specific endonuclease): GEN1/Yen1. Knockout of resolvase genes GEN1 and SEND1, individually or together, has no detectable effect on growth, fertility, or sensitivity to DNA damage. However, combined absence of the endonucleases MUS81 and SEND1 results in severe developmental defects, spontaneous cell death, and genome instability. A similar effect is not seen in mus81 gen1 plants, which develop normally and are fertile. Absence of RAD51 does not rescue mus81 send1, pointing to roles of these proteins in DNA replication rather than DNA break repair. The enrichment of S-phase histone γ-H2AX foci and a striking loss of telomeric DNA in mus81 send1 further support this interpretation. SEND1 has at most a minor role in resolution of the Holliday junction but acts as an essential backup to MUS81 for resolution of toxic replication structures to ensure genome stability and to maintain telomere integrity. PMID:26704385

  20. Sumoylation Is Important for Stability, Subcellular Localization, and Transcriptional Activity of SALL4, an Essential Stem Cell Transcription Factor*

    PubMed Central

    Yang, Feikun; Yao, Yixin; Jiang, Yongping; Lu, Luo; Ma, Yupo; Dai, Wei

    2012-01-01

    SALL4 is a transcription factor that plays a key role in the maintenance and self-renewal of embryonic stem cells and hematopoietic stem cells. Given that little is known about regulation of SALL4, we studied biochemical modifications of SALL4B, a major splicing variant of SALL4, and elucidated their biological function. SALL4B was primarily modified by ubiquitination when it was expressed in both Sf9 and HEK293T cells. A significant fraction of SALL4B was further modified by sumoylation when it was expressed in HEK293T cells. Constitutive SUMO-modification of SALL4B was also detected in Tera-1, a cell line of the teratocarcinoma origin. SALL4B sumoylation was independent of ubiquitination and lysine residues 156, 316, 374, and 401 were essential for sumoylation. Chromatin fraction contained more SUMO-deficient SALL4B. Despite a shorter half-life than the wild-type counterpart, SUMO-deficient SALL4B interacted with OCT4 more efficiently than the wild-type SALL4B. RNAi-mediated silencing of SALL4 expression caused significant down-regulation of both OCT4 and SOX2, which was rescued by ectopic expression of SALL4B but not by SUMO-deficient mutant. Significantly, compared with the wild-type SALL4B, SUMO-deficient mutant exhibited compromised trans-activation or trans-repression activities in reporter gene assays. Combined, our studies reveal sumoylation as a novel form of post-translational modification for regulating the stability, subcellular localization, and transcriptional activity of SALL4. PMID:23012367

  1. Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor.

    PubMed

    Yang, Feikun; Yao, Yixin; Jiang, Yongping; Lu, Luo; Ma, Yupo; Dai, Wei

    2012-11-01

    SALL4 is a transcription factor that plays a key role in the maintenance and self-renewal of embryonic stem cells and hematopoietic stem cells. Given that little is known about regulation of SALL4, we studied biochemical modifications of SALL4B, a major splicing variant of SALL4, and elucidated their biological function. SALL4B was primarily modified by ubiquitination when it was expressed in both Sf9 and HEK293T cells. A significant fraction of SALL4B was further modified by sumoylation when it was expressed in HEK293T cells. Constitutive SUMO-modification of SALL4B was also detected in Tera-1, a cell line of the teratocarcinoma origin. SALL4B sumoylation was independent of ubiquitination and lysine residues 156, 316, 374, and 401 were essential for sumoylation. Chromatin fraction contained more SUMO-deficient SALL4B. Despite a shorter half-life than the wild-type counterpart, SUMO-deficient SALL4B interacted with OCT4 more efficiently than the wild-type SALL4B. RNAi-mediated silencing of SALL4 expression caused significant down-regulation of both OCT4 and SOX2, which was rescued by ectopic expression of SALL4B but not by SUMO-deficient mutant. Significantly, compared with the wild-type SALL4B, SUMO-deficient mutant exhibited compromised trans-activation or trans-repression activities in reporter gene assays. Combined, our studies reveal sumoylation as a novel form of post-translational modification for regulating the stability, subcellular localization, and transcriptional activity of SALL4. PMID:23012367

  2. X-ray sensing materials stability: influence of ambient storage temperature on essential thermal properties of undoped vitreous selenium

    NASA Astrophysics Data System (ADS)

    Tonchev, D.; Mani, H.; Belev, G.; Kostova, I.; Kasap, S.

    2014-12-01

    Amorphous selenium (a-Se) is currently used in x-ray image detectors as an x-ray photoconductor. Normally a-Se films used in device applications are fabricated by the evaporation of vitreous bulk material loaded into boats in a typical vacuum deposition system. The resistance against crystallization is an important factor in both film and bulk forms of a-Se. Previous work has indicted that the resistance to crystallization is surprisingly more pronounced around 35 °C [1]. In this work we have therefore examined the essential thermal properties of vitreous selenium (99.999%) samples that have been stored at different temperatures. The thermal characterization experiments involved a series of DSC (Differential Scanning Calorimetry) measurements in which have monitored the glass transition and melting endotherms, and the crystallization exotherm in heating-cooling-heating scans. In DSC experiments, a sample would be heated to a temperature above the melting temperature, equilibrated, then cooled at a fixed rate down to 20 °C, then equilibrated and finally scanned again under a heating schedule. The samples were isothermally stored at temperatures corresponding to 18, 35 and 55 °C. The thermal analysis results show that there are distinct differences in the thermal properties. We have examined the stability in terms of the difference in the crystallization onset temperature (Tc) and the onset of glass transition temperature (Tg). We also examined the Hruby coefficient (Kgl) of these samples, that is Kgl = (Tc - Tg)/(Tm - Tc) where Tc is the crystallization onset temperature and Tm is the melting onset temperature. We have found Kgl to depend on the storage temperature. Surprisingly, we observed that the Hruby coefficient is actually larger at 35 °C compared to the values at 18 and 55 °C.

  3. Subunit CydX of Escherichia coli cytochrome bd ubiquinol oxidase is essential for assembly and stability of the di-heme active site.

    PubMed

    Hoeser, Jo; Hong, Sangjin; Gehmann, Gerfried; Gennis, Robert B; Friedrich, Thorsten

    2014-05-01

    Cytochrome bd ubiquinol oxidase uses the electron transport from ubiquinol to oxygen to establish a proton gradient across the membrane. The enzyme complex consists of subunits CydA and B and contains two b- and one d-type hemes as cofactors. Recently, it was proposed that a third subunit named CydX is essential for the function of the complex. Here, we show that CydX is indeed a subunit of purified Escherichia coli cytochrome bd oxidase and that the small protein is needed either for the assembly or the stability of the active site di-heme center and, thus, is essential for oxidase activity. PMID:24681096

  4. Chloroplast targeting of FtsHprotease is essential for chloroplast development and thylakoid stability at elevated temperatures in plants

    Technology Transfer Automated Retrieval System (TEKTRAN)

    AtFtsH11 is a chloroplast and mitochondria dual targeted metalloprotease, identified as essential for Arabidopsis plant to survive at moderate high temperatures at all developmental stages. Our study showed that FtsH11 plays critical roles in both the early stages of chloroplast biogenesis and main...

  5. Experimental Verification of the Rudder-Free Stability Theory for an Airplane Model Equipped with Rudders Having Negative Floating Tendency and Negligible Friction

    NASA Technical Reports Server (NTRS)

    McKinney, Marion O.; Maggin, Bernard

    1944-01-01

    An investigation has been made in the Langley free-flight tunnel to obtain an experimental verification of the theoretical rudder-free stability characteristics of an airplane model equipped with conventional rudders having negative floating tendencies and negligible friction. The model used in the tests was equipped with a conventional single vertical tail having rudder area 40 percent of the vertical tail area. The model was tested both in free flight and mounted on a strut that allowed freedom only in yaw. Tests were made with three different amounts of rudder aerodynamic balance and with various values of mass, moment of inertia, and center-of-gravity location of the rudder. Most of the stability derivatives required for the theoretical calculations were determined from forced and free-oscillation tests of the particular model tested. The theoretical analysis showed that the rudder-free motions of an airplane consist largely of two oscillatory modes - a long-period oscillation somewhat similar to the normal rudder-fixed oscillation and a short-period oscillation introduced only when the rudder is set free. It was found possible in the tests to create lateral instability of the rudder-free short-period mode by large values of rudder mass parameters even though the rudder-fixed condition was highly stable. The results of the tests and calculation indicated that for most present-day airplanes having rudders of negative floating tendency, the rudder-free stability characteristics may be examined by simply considering the dynamic lateral stability using the value of the directional-stability parameter Cn(sub p) for the rudder-free condition in the conventional controls-fixed lateral-stability equations. For very large airplanes having relatively high values of the rudder mass parameters with respect to the rudder aerodynamic parameters, however, analysis of the rudder-free stability should be made with the complete equations of motion. Good agreement between calculated and measured rudder-free stability characteristics was obtained by use of the general rudder-free stability theory, in which four degrees of lateral freedom are considered. When this assumption is made that the rolling motions alone or the lateral and rolling motions may be neglected in the calculations of rudder-free stability, it is possible to predict satisfactorily the characteristics of the long-period (Dutch roll type) rudder-free oscillation for airplanes only when the effective-dihedral angle is small. With these simplifying assumptions, however, satisfactory prediction of the short-period oscillation may be obtained for any dihedral. Further simplification of the theory based on the assumption that the rudder moment of inertia might be disregarded was found to be invalid because this assumption made it impossible to calculate the characteristics of the short-period oscillations.

  6. Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection

    PubMed Central

    Seu, Lillian; Sabbaj, Steffanie; Duverger, Alexandra; Wagner, Frederic; Anderson, Joshua C.; Davies, Elizabeth; Wolschendorf, Frank; Willey, Christopher D.; Saag, Michael S.; Goepfert, Paul

    2015-01-01

    ABSTRACT The extreme stability of the latent HIV-1 reservoir in the CD4+ memory T cell population prevents viral eradication with current antiretroviral therapy. It has been demonstrated that homeostatic T cell proliferation and clonal expansion of latently infected T cells due to viral integration into specific genes contribute to this extraordinary reservoir stability. Nevertheless, given the constant exposure of the memory T cell population to specific antigen or bystander activation, this reservoir stability seems remarkable, unless it is assumed that latent HIV-1 resides exclusively in memory T cells that recognize rare antigens. Another explanation for the stability of the reservoir could be that the latent HIV-1 reservoir is associated with an unresponsive T cell phenotype. We demonstrate here that host cells of latent HIV-1 infection events were functionally altered in ways that are consistent with the idea of an anergic, unresponsive T cell phenotype. Manipulations that induced or mimicked an anergic T cell state promoted latent HIV-1 infection. Kinome analysis data reflected this altered host cell phenotype at a system-wide level and revealed how the stable kinase activity changes networked to stabilize latent HIV-1 infection. Protein-protein interaction networks generated from kinome data could further be used to guide targeted genetic or pharmacological manipulations that alter the stability of latent HIV-1 infection. In summary, our data demonstrate that stable changes to the signal transduction and transcription factor network of latently HIV-1 infected host cells are essential to the ability of HIV-1 to establish and maintain latent HIV-1 infection status. IMPORTANCE The extreme stability of the latent HIV-1 reservoir allows the infection to persist for the lifetime of a patient, despite completely suppressive antiretroviral therapy. This extreme reservoir stability is somewhat surprising, since the latently HIV-1 infected CD4+ memory T cells that form the structural basis of the viral reservoir should be exposed to cognate antigen over time. Antigen exposure would trigger a recall response and should deplete the reservoir, likely over a relatively short period. Our data demonstrate that stable and system-wide phenotypic changes to host cells are a prerequisite for the establishment and maintenance of latent HIV-1 infection events. The changes observed are consistent with an unresponsive, anergy-like T cell phenotype of latently HIV-1 infected host cells. An anergy-like, unresponsive state of the host cells of latent HIV-1 infection events would explain the stability of the HIV-1 reservoir in the face of continuous antigen exposure. PMID:25878110

  7. Structural Stability of Human Fibroblast Growth Factor-1 Is Essential for Protective Effects Against Radiation-Induced Intestinal Damage

    SciTech Connect

    Nakayama, Fumiaki; Umeda, Sachiko; Yasuda, Takeshi; Asada, Masahiro; Motomura, Kaori; Suzuki, Masashi; Zakrzewska, Malgorzata; Imamura, Toru; Imai, Takashi

    2013-02-01

    Purpose: Human fibroblast growth factor-1 (FGF1) has radioprotective effects on the intestine, although its structural instability limits its potential for practical use. Several stable FGF1 mutants were created increasing stability in the order, wild-type FGF1, single mutants (Q40P, S47I, and H93G), Q40P/S47I, and Q40P/S47I/H93G. This study evaluated the contribution of the structural stability of FGF1 to its radioprotective effect. Methods and Materials: Each FGF1 mutant was administered intraperitoneally to BALB/c mice in the absence of heparin 24 h before or after total body irradiation (TBI) with {gamma}-rays at 8-12 Gy. Several radioprotective effects were examined in the jejunum. Results: Q40P/S47I/H93G could activate all subtypes of FGF receptors in vitro much more strongly than the wild-type without endogenous or exogenous heparin. Preirradiation treatment with Q40P/S47I/H93G significantly increased crypt survival more than wild-type FGF1 after TBI at 10 or 12 Gy, and postirradiation treatment with Q40P/S47I/H93G was effective in promoting crypt survival after TBI at 10, 11, or 12 Gy. In addition, crypt cell proliferation, crypt depth, and epithelial differentiation were significantly promoted by postirradiation treatment with Q40P/S47I/H93G. The level of stability of FGF1 mutants correlated with their mitogenic activities in vitro in the absence of heparin; however, preirradiation treatment with the mutants increased the crypt number to almost the same level as Q40P/S47I/H93G. When given 24 h after TBI at 10 Gy, all FGF1 mutants increased crypt survival more than wild-type FGF1, and Q40P/S47I/H93G had the strongest mitogenic effects in intestinal epithelial cells after radiation damage. Moreover, Q40P/S47I/H93G prolonged mouse survival after TBI because of the repair of intestinal damage. Conclusion: These findings suggest that the structural stability of FGF1 can contribute to the enhancement of protective effects against radiation-induced intestinal damage. Therefore, Q40P/S47I/H93G is pharmacologically one of the most promising candidates for clinical applications for radiation-induced gastrointestinal syndrome.

  8. Fabrication, stability and efficacy of dual-component antimicrobial nanoemulsions: essential oil (thyme oil) and cationic surfactant (lauric arginate).

    PubMed

    Chang, Yuhua; McLandsborough, Lynne; McClements, David Julian

    2015-04-01

    The influence of a cationic surfactant (lauric arginate, LAE) on the physical properties and antimicrobial efficacy of thyme oil nanoemulsions was investigated. Nanoemulsions prepared from pure thyme oil were highly unstable due to Ostwald ripening, but they could be stabilized by adding a ripening inhibitor (corn oil) to the oil phase prior to homogenisation. The loading capacity and antimicrobial efficacy of thyme oil nanoemulsions were significantly increased by adding LAE. In the absence of LAE, at least 60 wt% corn oil had to be added to the lipid phase to inhibit Ostwald ripening; but in the presence of 0.1 wt% LAE, only 30 wt% corn oil was needed. LAE addition substantially increased the antimicrobial efficacy of the thyme oil nanoemulsions: 200 μg/ml thyme oil was needed to inhibit growth of a spoilage yeast (Zygosaccharomyces bailii) if LAE was added, whereas ⩾ 400 μg/ml was needed in the absence of LAE. PMID:25442557

  9. Stabilities of thiomolybdate complexes of iron; implications for retention of essential trace elements (Fe, Cu, Mo) in sulfidic waters.

    PubMed

    Helz, George R; Erickson, Britt E; Vorlicek, Trent P

    2014-06-01

    In aquatic ecosystems, availabilities of Fe, Mo and Cu potentially limit rates of critical biological processes, including nitrogen fixation, nitrate assimilation and N2O decomposition. During long periods in Earth's history when large parts of the ocean were sulfidic, what prevented these elements' quantitative loss from marine habitats as insoluble sulfide phases? They must have been retained by formation of soluble complexes. Identities of the key ligands are poorly known but probably include thioanions. Here, the first determinations of stability constants for Fe(2+)-[MoS4](2-) complexes in aqueous solution are reported based on measurements of pyrrhotite (hexagonal FeS) solubility under mildly alkaline conditions. Two linear complexes, [FeO(OH)MoS4](3-) and [(Fe2S2)(MoS4)2](4-), best explain the observed solubility variations. Complexes that would be consistent with cuboid cluster structures were less successful, implying that such clusters probably are minor or absent in aqueous solution under the conditions studied. The new data, together with prior data on stabilities of Cu(+)-[MoS4](2-) complexes, are used to explore computationally how competition of Fe(2+) and Cu(+) for [MoS4](2-), as well as competition of [MoS4](2-) and HS(-) for both metals would be resolved in solutions representative of sulfidic natural waters. Thiomolybdate complexes will be most important at sulfide concentrations near the [MoO4](2-)-[MoS4](2-) equivalence point. At lower sulfide concentrations, thiomolybdates are insufficiently stable to be competitive ligands in natural waters and at higher sulfide concentrations HS(-) ligands out-compete thiomolybdates. PMID:24226648

  10. Essential role of the N- and C-terminals of laccase from Pleurotus florida on the laccase activity and stability.

    PubMed

    Hu, Meirong; Zhou, Xue; Shi, Yiping; Lin, Jianhui; Irfan, Muhammad; Tao, Yong

    2014-11-01

    POXA1b is the most thermostable laccase isoenzyme from Pleurotus ostreatus. POXA1b is remarkably stable at alkaline pH (the t1/2 at pH 10 was 30 days), and its C-terminal affects its catalytic and stability properties. We cloned POXA1c from P. florida, which showed 99 % identity with POXA1b. POXA1c was functionally expressed in Pichia pastoris. The functions of the N and C termini of POXA1c were investigated using site-directed mutagenesis. Compared with POXA1c, the N-terminal R5V site effectively increased the specific activities for 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and guaiacol by 2- and 3.5-fold, respectively. A C-terminal truncated mutant, POXA1c?13, also increased the specific activities for ABTS and guaiacol by 2.3- and 3.4-fold, respectively. A double mutant, POXA1c?13-R5V, combined the R5V and ?13 effects. The specific activity of this double mutant for ABTS was 1,321 U/mg, which indicated a 4-fold increase compared with the wild type. The role of residue V5 on laccase catalytic properties was also observed for laccases from Trametes versicolor and Rigidoporus lignosus. The specific activities of the V5R of the laccases from T. versicolor and R. lignosus were half of that of the wild type. The pH and thermal stability analysis of POXA1c and its mutants showed that the enzymes were remarkably stable because they showed 63 % residual activity after incubation for 108 h at 30 C over a pH range of 4.5 to 9.0. Similar results were observed for POXA1c?13-R5V. POXA1c?13-R5V can be widely used in industrial biotechnology because of its excellent catalytic properties. PMID:25161036

  11. Effect of thyme/cumin essential oils and butylated hydroxyl anisole/butylated hydroxyl toluene on physicochemical properties and oxidative/microbial stability of chicken patties.

    PubMed

    Sariçoban, Cemalettin; Yilmaz, Mustafa Tahsin

    2014-02-01

    In this study, effects of thyme/cumin essential oils (EO) and butylated hydroxyl anisole (BHA)/butylated hydroxyl toluene (BHT) on physicochemical properties and storage stability of chicken patties were compared in different storage periods (0, 3, 7, 14, 21, and 28 d). It was found that there were significant (P < 0.05) differences between physicochemical properties of patty samples treated with EO and the synthetic antioxidants. The EO showed similar performance to those of BHA and BHT in limiting TBARS values of chicken patty samples. Similarity in performance was also the case for microbial stability (total aerobic mesophilic, psychrotrophic, lactic acid, and coliform bacteria as well as molds and yeasts); namely, their effects were significant (P < 0.05). Effect of thyme EO was significant (P < 0.05) and remarkable, not allowing any coliform bacteria to grow in the samples. Given that EO were obtained from natural sources, the data suggested that the EO might be more useful than their synthetic counterparts, BHA and BHT, as additives for chicken patties to maintain oxidative/microbial stability and increase shelf life. PMID:24570469

  12. A conserved π-cation and an electrostatic bridge are essential for 11R-lipoxygenase catalysis and structural stability.

    PubMed

    Eek, Priit; Piht, Mari-Ann; Rätsep, Margus; Freiberg, Arvi; Järving, Ivar; Samel, Nigulas

    2015-10-01

    Lipoxygenases (LOXs) are lipid-peroxidizing enzymes that consist of a regulatory calcium- and membrane-binding PLAT (polycystin-1, lipoxygenase, α-toxin) domain and a catalytic domain. In a previous study, the crystal structure of an 11R-LOX revealed a conserved π-cation bridge connecting these two domains which could mediate the regulatory effect of the PLAT domain to the active site. Here we analyzed the role of residues Trp107 and Lys172 that constitute the π-cation bridge in 11R-LOX along with Arg106 and Asp173-a potential salt bridge, which could also contribute to the inter-domain communication. According to our kinetic assays and protein unfolding experiments conducted using differential scanning fluorimetry and circular dichroism spectroscopy, mutants with a disrupted link display diminished catalytic activity alongside reduced stability of the protein fold. The results demonstrate that both these bridges contribute to the two-domain interface, and are important for proper enzyme activation. PMID:26215075

  13. The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability

    SciTech Connect

    Choi, Myung-Suk; Min, Sang-Hyun; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 ; Jung, Haiyoung; Lee, Ju Dong; Lee, Tae Ho; Lee, Heung Kyu; Yoo, Ook-Joon

    2011-03-11

    Research highlights: {yields} FKBP38 interacts with PRL-3. {yields} FKBP38 promotes degradation of endogenous PRL-3 protein via protein-proteasome pathway. {yields} FKBP38 suppresses PRL-3 oncogenic function. {yields} FKBP38 is a novel negative regulator of the oncogenic protein PRL-3. -- Abstract: The phosphatase of regenerating liver-3 (PRL-3) is a member of protein tyrosine phosphatases and whose deregulation is implicated in tumorigenesis and metastasis of many cancers. However, the underlying mechanism by which PRL-3 is regulated is not known. In this study, we identified the peptidyl prolyl cis/trans isomerase FK506-binding protein 38 (FKBP38) as an interacting protein of PRL-3 using a yeast two-hybrid system. FKBP38 specifically binds to PRL-3 in vivo, and that the N-terminal region of FKBP38 is crucial for binding with PRL-3. FKBP38 overexpression reduces endogenous PRL-3 expression levels, whereas the depletion of FKBP38 by siRNA increases the level of PRL-3 protein. Moreover, FKBP38 promotes degradation of endogenous PRL-3 protein via protein-proteasome pathway. Furthermore, FKBP38 suppresses PRL-3-mediated p53 activity and cell proliferation. These results demonstrate that FKBP38 is a novel regulator of the oncogenic protein PRL-3 abundance and that alteration in the stability of PRL-3 can have a dramatic impact on cell proliferation. Thus, FKBP38 may play a critical role in tumorigenesis.

  14. RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability.

    PubMed

    Satrimafitrah, Pasjan; Barman, Hirak Kumar; Ahmad, Ahyar; Nishitoh, Hideki; Nakayama, Tatsuo; Fukagawa, Tatsuo; Takami, Yasunari

    2016-05-01

    RbAp46/48, histone chaperone, is a family of evolutionarily conserved WD40 repeat-containing proteins, which are involved in various chromatin-metabolizing processes, but their in vivo functional relevance is yet unclear. In order to examine the biological role of pRbAp48 in chicken DT40 cells, we generated a tetracycline-inducible system for conditional RbAp48-knockout cells. Depletion of RbAp48 led to delayed S phase progression associated with slow DNA synthesis and nascent nucleosome formation, followed by accumulation in G2/M phase, finally leading to cell death. Prior to cell death, these cells exhibited aberrant mitosis such as highly condensed and abnormal chromosome alignment on the metaphase plate, leading to chromosome missegregation. Depletion of RbAp48 also caused dissociation of heterochromatin protein 1 (HP1) from pericentromeric heterochromatin. Furthermore, depletion of RbAp48 from cells led to elevated levels of acetylation and slightly decreased levels of methylation, specifically at Lys-9 residue of histone H3. These results suggest that RbAp48 plays an important role in chromosome stability for proper organization of heterochromatin structure through the regulation of epigenetic mark. PMID:26667624

  15. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes

    PubMed Central

    Zemljic-Harpf, Alice E.; Godoy, Joseph C.; Platoshyn, Oleksandr; Asfaw, Elizabeth K.; Busija, Anna R.; Domenighetti, Andrea A.; Ross, Robert S.

    2014-01-01

    ABSTRACT Vinculin (Vcl) links actin filaments to integrin- and cadherin-based cellular junctions. Zonula occludens-1 (ZO-1, also known as TJP1) binds connexin-43 (Cx43, also known as GJA1), cadherin and actin. Vcl and ZO-1 anchor the actin cytoskeleton to the sarcolemma. Given that loss of Vcl from cardiomyocytes causes maldistribution of Cx43 and predisposes cardiomyocyte-specific Vcl-knockout mice with preserved heart function to arrhythmia and sudden death, we hypothesized that Vcl and ZO-1 interact and that loss of this interaction destabilizes gap junctions. We found that Vcl, Cx43 and ZO-1 colocalized at the intercalated disc. Loss of cardiomyocyte Vcl caused parallel loss of ZO-1 from intercalated dics. Vcl co-immunoprecipitated Cx43 and ZO-1, and directly bound ZO-1 in yeast two-hybrid studies. Excision of the Vcl gene in neonatal mouse cardiomyocytes caused a reduction in the amount of Vcl mRNA transcript and protein expression leading to (1) decreased protein expression of Cx43, ZO-1, talin, and β1D-integrin, (2) reduced PI3K activation, (3) increased activation of Akt, Erk1 and Erk2, and (4) cardiomyocyte necrosis. In summary, this is the first study showing a direct interaction between Vcl and ZO-1 and illustrates how Vcl plays a crucial role in stabilizing gap junctions and myocyte integrity. PMID:24413171

  16. Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression.

    PubMed

    Yuri, Shunsuke; Fujimura, Sayoko; Nimura, Keisuke; Takeda, Naoki; Toyooka, Yayoi; Fujimura, Yu-Ichi; Aburatani, Hiroyuki; Ura, Kiyoe; Koseki, Haruhiko; Niwa, Hitoshi; Nishinakamura, Ryuichi

    2009-04-01

    Sall4 is a mouse homolog of a causative gene of the autosomal dominant disorder Okihiro syndrome. We previously showed that the absence of Sall4 leads to lethality during peri-implantation and that Sall4-null embryonic stem (ES) cells proliferate poorly with intact pluripotency when cultured on feeder cells. Here, we report that, in the absence of feeder cells, Sall4-null ES cells express the trophectoderm marker Cdx2, but are maintained for a long period in an undifferentiated state with minimally affected Oct3/4 expression. Feeder-free Sall4-null ES cells contribute solely to the inner cell mass and epiblast in vivo, indicating that these cells still retain pluripotency and do not fully commit to the trophectoderm. These phenotypes could arise from derepression of the Cdx2 promoter, which is normally suppressed by Sall4 and the Mi2/NuRD HDAC complex. However, proliferation was impaired and G1 phase prolonged in the absence of Sall4, suggesting another role for Sall4 in cell cycle control. Although Sall1, also a Sall family gene, is known to genetically interact with Sall4 in vivo, Sall1-null ES cells have no apparent defects and no exacerbation is observed in ES cells lacking both Sall1 and Sall4, compared with Sall4-null cells. This suggests a unique role for Sall4 in ES cells. Thus, though Sall4 does not contribute to the central machinery of the pluripotency, it stabilizes ES cells by repressing aberrant trophectoderm gene expression. PMID:19350679

  17. Stabilization of Speckle-type POZ Protein (Spop) by Daz Interacting Protein 1 (Dzip1) Is Essential for Gli Turnover and the Proper Output of Hedgehog Signaling*

    PubMed Central

    Schwend, Tyler; Jin, Zhigang; Jiang, Kai; Mitchell, Brian J.; Jia, Jianhang; Yang, Jing

    2013-01-01

    The Hedgehog (Hh) pathway is essential for embryonic development and adult tissue homeostasis. The Gli/Cubitus interruptus (Ci) family of transcription factors acts at the downstream end of the pathway to mediate Hh signaling. Both Hh-dependent and -independent Gli regulatory mechanisms are important for the output of Hh signaling. Daz interacting protein 1 (Dzip1) has bipartite positive and negative functions in the Hh pathway. The positive Hh regulatory function appears to be attributed to a requirement for Dzip1 during ciliogenesis. The mechanism by which Dzip1 inhibits Hh signaling, however, remains largely unclear. We recently found that Dzip1 is required for Gli turnover, which may account for its inhibitory function in Hh signaling. Here, we report that Dzip1 regulates Gli/Ci turnover by preventing degradation of speckle-type POZ protein (Spop), a protein that promotes proteasome-dependent turnover of Gli proteins. We provide evidence that Dzip1 regulates the stability of Spop independent of its function in ciliogenesis. Partial knockdown of Dzip1 to levels insufficient for perturbing ciliogenesis, sensitized Xenopus embryos to Hh signaling, leading to phenotypes that resemble activation of Hh signaling. Importantly, overexpression of Spop was able to restore proper Gli protein turnover and rescue phenotypes in Dzip1-depleted embryos. Consistently, depletion of Dzip1 in Drosophila S2 cells destabilized Hh-induced BTB protein (HIB), the Drosophila homolog of Spop, and increased the level of Ci. Thus, Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway. PMID:24072710

  18. Anti-rancidity effect of essential oils, application in the lipid stability of cooked turkey meat patties and potential implications for health.

    PubMed

    Loizzo, Monica R; Tundis, Rosa; Menichini, Francesco; Duthie, Garry

    2015-02-01

    Twenty-three commercial essential oils were tested for their anti-rancidity effect and potential implications to prolong the induction time of corn oil and extend the shelf life of cooked turkey patties. Moreover, the potential health benefit was investigated through DPPH, ABTS, β-carotene bleaching, FRAP, and α-amylase inhibitory assays. Essential oils' composition was investigated by GC-MS. Cumin, thyme, clove, and cinnamon oils improved oxidative stability and increased the induction time of the corn oil 1.5-3 fold. Clove and cinnamon oils were particularly effective in delaying lipid oxidation of cooked turkey patties (time of induction 11.04 and 9.43 h) compared with the plain burger (5.04 h). Both oils are also characterized by a potent radical scavenging activity in ABTS test (IC(50) values of 1.43 and 2.05 μg/ml for cinnamon and clove, respectively). In the α-amylase inhibitory assay, cumin and grape fruits were the most potent with IC(50) values of 21.88 and 23.95 μg/ml, respectively. PMID:25265207

  19. Essential Tremor

    MedlinePlus

    MENU Return to Web version Essential Tremor Overview What is essential tremor? Essential tremor, sometimes called benign (non-cancerous) or familial tremor, is an uncontrollable shaking, most often in ...

  20. A Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 Receptors.

    PubMed

    Zhao, Wen-Shan; Sun, Meng-Yang; Sun, Liang-Fei; Liu, Yan; Yang, Yang; Huang, Li-Dong; Fan, Ying-Zhe; Cheng, Xiao-Yang; Cao, Peng; Hu, You-Min; Li, Lingyong; Tian, Yun; Wang, Rui; Yu, Ye

    2016-04-01

    Significant progress has been made in understanding the roles of crucial residues/motifs in the channel function of P2X receptors during the pre-structure era. The recent structural determination of P2X receptors allows us to reevaluate the role of those residues/motifs. Residues Arg-309 and Asp-85 (rat P2X4 numbering) are highly conserved throughout the P2X family and were involved in loss-of-function polymorphism in human P2X receptors. Previous studies proposed that they participated in direct ATP binding. However, the crystal structure of P2X demonstrated that those two residues form an intersubunit salt bridge located far away from the ATP-binding site. Therefore, it is necessary to reevaluate the role of this salt bridge in P2X receptors. Here, we suggest the crucial role of this structural element both in protein stability and in channel gating rather than direct ATP interaction and channel assembly. Combining mutagenesis, charge swap, and disulfide cross-linking, we revealed the stringent requirement of this salt bridge in normal P2X4 channel function. This salt bridge may contribute to stabilizing the bending conformation of the β2,3-sheet that is structurally coupled with this salt bridge and the α2-helix. Strongly kinked β2,3 is essential for domain-domain interactions between head domain, dorsal fin domain, right flipper domain, and loop β7,8 in P2X4 receptors. Disulfide cross-linking with directions opposing or along the bending angle of the β2,3-sheet toward the α2-helix led to loss-of-function and gain-of-function of P2X4 receptors, respectively. Further insertion of amino acids with bulky side chains into the linker between the β2,3-sheet or the conformational change of the α2-helix, interfering with the kinked conformation of β2,3, led to loss-of-function of P2X4 receptors. All these findings provided new insights in understanding the contribution of the salt bridge between Asp-85 and Arg-309 and its structurally coupled β2,3-sheet to the function of P2X receptors. PMID:26865631

  1. NdhP Is an Exclusive Subunit of Large Complex of NADPH Dehydrogenase Essential to Stabilize the Complex in Synechocystis sp. Strain PCC 6803*

    PubMed Central

    Zhang, Jingsong; Gao, Fudan; Zhao, Jiaohong; Ogawa, Teruo; Wang, Quanxi; Ma, Weimin

    2014-01-01

    Two major complexes of NADPH dehydrogenase (NDH-1) have been identified in cyanobacteria. A large complex (NDH-1L) contains NdhD1 and NdhF1, which are absent in a medium size complex (NDH-1M). They play important roles in respiration, cyclic electron transport around photosystem I, and CO2 acquisition. Two mutants sensitive to high light for growth and impaired in NDH-1-mediated cyclic electron transfer were isolated from Synechocystis sp. strain PCC 6803 transformed with a transposon-bearing library. Both mutants had a tag in sml0013 encoding NdhP, a single transmembrane small subunit of the NDH-1 complex. During prolonged incubation of the wild type thylakoid membrane with n-dodecyl β-d-maltoside (DM), about half of the NDH-1L was disassembled to NDH-1M and the rest decomposed completely without forming NDH-1M. In the ndhP deletion mutant (ΔndhP), disassembling of NDH-1L to NDH-1M occurred even on ice, and decomposition to a small piece occurred at room temperature much faster than in the wild type. Deletion of the C-terminal tail of NdhP gave the same result. The C terminus of NdhP was tagged by YFP-His6. Blue native gel electrophoresis of the DM-treated thylakoid membrane of this strain and Western analysis using the antibody against GFP revealed that NdhP-YFP-His6 was exclusively confined to NDH-1L. During prolonged incubation of the thylakoid membrane of the tagged strain with DM at room temperature, NDH-1L was partially disassembled to NDH-1M and the 160-kDa band containing NdhP-YFP-His6 and possibly NdhD1 and NdhF1. We therefore conclude that NdhP, especially its C-terminal tail, is essential to assemble NdhD1 and NdhF1 and stabilize the NDH-1L complex. PMID:24847053

  2. Essential Tremor

    MedlinePlus

    ... Enhancing Diversity Find People About NINDS NINDS Essential Tremor Information Page Table of Contents (click to jump ... being done? Clinical Trials Organizations What is Essential Tremor? Tremor is an unintentional, somewhat rhythmic, muscle movement ...

  3. Thin, a Trim32 ortholog, is essential for myofibril stability and is required for the integrity of the costamere in Drosophila

    PubMed Central

    LaBeau-DiMenna, Elisa M.; Clark, Kathleen A.; Bauman, Kenneth D.; Parker, Daniel S.; Cripps, Richard M.; Geisbrecht, Erika R.

    2012-01-01

    Myofibril stability is required for normal muscle function and maintenance. Mutations that disrupt myofibril stability result in individuals who develop progressive muscle wasting, or muscular dystrophy, and premature mortality. Here we present our investigations of the Drosophila l(2)thin [l(2)tn] mutant. The thin phenotype exhibits features of the human muscular disease phenotype in that tn mutant larvae show progressive muscular degeneration. Loss-of-function and rescue experiments determined that l(2)tn is allelic to the tn locus [previously annotated as both CG15105 and another b-box affiliate (abba)]. tn encodes a TRIM (tripartite motif) containing protein highly expressed in skeletal muscle and is orthologous to the human limb-girdle muscular dystrophy type 2H disease gene Trim32. Thin protein is localized at the Z-disk in muscle, but l(2)tn mutants showed no genetic interaction with mutants affecting the Z-lineassociated protein muscle LIM protein 84B. l(2)tn, along with loss-of-function mutants generated for tn, showed no relative mislocalization of the Z-disk proteins ?-Actinin and muscle LIM protein 84B. In contrast, tn mutants had significant disorganization of the costameric orthologs ?-integrin, Spectrin, Talin, and Vinculin, and we present the initial description for the costamere, a key muscle stability complex, in Drosophila. Our studies demonstrate that myofibrils progressively unbundle in flies that lack Thin function through progressive costamere breakdown. Due to the high conservation of these structures in animals, we demonstrate a previously unknown role for TRIM32 proteins in myofibril stability. PMID:23071324

  4. Solar Equipment

    NASA Technical Reports Server (NTRS)

    1983-01-01

    A medical refrigeration and a water pump both powered by solar cells that convert sunlight directly into electricity are among the line of solar powered equipment manufactured by IUS (Independent Utility Systems) for use in areas where conventional power is not available. IUS benefited from NASA technology incorporated in the solar panel design and from assistance provided by Kerr Industrial Applications Center.

  5. Telescope Equipment

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Renaissance Telescope for high resolution and visual astronomy has five 82-degree Field Tele-Vue Nagler Eyepieces, some of the accessories that contribute to high image quality. Telescopes and eyepieces are representative of a family of optical equipment manufactured by Tele-Vue Optics, Inc.

  6. USGS Equipment

    USGS traveling equipment above Minot, North Dakota. USGS personnel were measuring the streamflow of the Souris River above Minot, ND on June 24, 2011.  Streamflow was approximately 20,800 cubic feet per second, stage approximately 23.46 feet....

  7. Suitable features selection for monitoring thermal condition of electrical equipment using infrared thermography

    NASA Astrophysics Data System (ADS)

    Huda, A. S. N.; Taib, S.

    2013-11-01

    Monitoring the thermal condition of electrical equipment is necessary for maintaining the reliability of electrical system. The degradation of electrical equipment can cause excessive overheating, which can lead to the eventual failure of the equipment. Additionally, failure of equipment requires a lot of maintenance cost, manpower and can also be catastrophic- causing injuries or even deaths. Therefore, the recognition processof equipment conditions as normal and defective is an essential step towards maintaining reliability and stability of the system. The study introduces infrared thermography based condition monitoring of electrical equipment. Manual analysis of thermal image for detecting defects and classifying the status of equipment take a lot of time, efforts and can also lead to incorrect diagnosis results. An intelligent system that can separate the equipment automatically could help to overcome these problems. This paper discusses an intelligent classification system for the conditions of equipment using neural networks. Three sets of features namely first order histogram based statistical, grey level co-occurrence matrix and component based intensity features are extracted by image analysis, which are used as input data for the neural networks. The multilayered perceptron networks are trained using four different training algorithms namely Resilient back propagation, Bayesian Regulazation, Levenberg-Marquardt and Scale conjugate gradient. The experimental results show that the component based intensity features perform better compared to other two sets of features. Finally, after selecting the best features, multilayered perceptron network trained using Levenberg-Marquardt algorithm achieved the best results to classify the conditions of electrical equipment.

  8. Essential Questions

    ERIC Educational Resources Information Center

    Wilhelm, Jeffrey D.

    2012-01-01

    The secret to teaching may be as simple as asking students good questions--and then giving them the opportunity to find the answers. The author shares how he uses essential questions that set the class off on an inquiry. Rather than consuming information that he distributes and then repeating it on a test, students carry out their own…

  9. Research essentials.

    PubMed

    Chudleigh, Jane; Smith, Joanna

    2016-02-01

    IDENTIFYING a funding body is daunting in an increasingly competitive market. It is essential to consider whether you, your workplace and your project meet funding body objectives and application criteria. A comprehensive list of funding bodies can be found at the RCN website, at tinyurl.com/h74rg86. PMID:26856566

  10. Efficiency of vanilla, patchouli and ylang ylang essential oils stabilized by iron oxide@C14 nanostructures against bacterial adherence and biofilms formed by Staphylococcus aureus and Klebsiella pneumoniae clinical strains.

    PubMed

    Bilcu, Maxim; Grumezescu, Alexandru Mihai; Oprea, Alexandra Elena; Popescu, Roxana Cristina; Mogoșanu, George Dan; Hristu, Radu; Stanciu, George A; Mihailescu, Dan Florin; Lazar, Veronica; Bezirtzoglou, Eugenia; Chifiriuc, Mariana Carmen

    2014-01-01

    Biofilms formed by bacterial cells are associated with drastically enhanced resistance against most antimicrobial agents, contributing to the persistence and chronicization of the microbial infections and to therapy failure. The purpose of this study was to combine the unique properties of magnetic nanoparticles with the antimicrobial activity of three essential oils to obtain novel nanobiosystems that could be used as coatings for catheter pieces with an improved resistance to Staphylococcus aureus and Klebsiella pneumoniae clinical strains adherence and biofilm development. The essential oils of ylang ylang, patchouli and vanilla were stabilized by the interaction with iron oxide@C14 nanoparticles to be further used as coating agents for medical surfaces. Iron oxide@C14 was prepared by co-precipitation of Fe+2 and Fe+3 and myristic acid (C14) in basic medium. Vanilla essential oil loaded nanoparticles pelliculised on the catheter samples surface strongly inhibited both the initial adherence of S. aureus cells (quantified at 24 h) and the development of the mature biofilm quantified at 48 h. Patchouli and ylang-ylang essential oils inhibited mostly the initial adherence phase of S. aureus biofilm development. In the case of K. pneumoniae, all tested nanosystems exhibited similar efficiency, being active mostly against the adherence K. pneumoniae cells to the tested catheter specimens. The new nanobiosystems based on vanilla, patchouli and ylang-ylang essential oils could be of a great interest for the biomedical field, opening new directions for the design of film-coated surfaces with anti-adherence and anti-biofilm properties. PMID:25375335

  11. Essential debate.

    PubMed

    Zigmond, Jessica

    2012-11-26

    With the election settled, the Obama administration has forged ahead with a draft rule on essential benefits and other provisions under the Affordable Care Act. Key players are still digesting the proposals, but HHS Secretary Kathleen Sebelius, left, says she's confident that the new rules-and an extended deadline related to exchanges-will give states what they need to implement the law. PMID:23326870

  12. Rescue Equipment

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Lifeshear cutter, a rescue tool for freeing accident victims from wreckage, was developed under the Clinton Administration's Technology Reinvestment Program. Prior cutting equipment was cumbersome and expensive; the new cutter is 50 percent lighter and 70 percent cheaper. The cutter is pyrotechnically-actuated, using a miniature version of the power cartridges used for separation devices on the Space Shuttle and other NASA spacecraft. Hi-Shear Technology Corporation developed the cutter with the Jet Propulsion Laboratory and input from the City of Torrance (California) Fire Department.

  13. Histone Acetyl Transferase 1 Is Essential for Mammalian Development, Genome Stability, and the Processing of Newly Synthesized Histones H3 and H4

    PubMed Central

    Nagarajan, Prabakaran; Ge, Zhongqi; Sirbu, Bianca; Doughty, Cheryl; Agudelo Garcia, Paula A.; Schlederer, Michaela; Annunziato, Anthony T.; Cortez, David; Kenner, Lukas; Parthun, Mark R.

    2013-01-01

    Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the function of this enzyme in a complex organism, we have constructed a conditional mouse knockout model of Hat1. Murine Hat1 is essential for viability, as homozygous deletion of Hat1 results in neonatal lethality. The lungs of embryos and pups genetically deficient in Hat1 were much less mature upon histological evaluation. The neonatal lethality is due to severe defects in lung development that result in less aeration and respiratory distress. Many of the Hat1−/− neonates also display significant craniofacial defects with abnormalities in the bones of the skull and jaw. Hat1−/− mouse embryonic fibroblasts (MEFs) are defective in cell proliferation and are sensitive to DNA damaging agents. In addition, the Hat1−/− MEFs display a marked increase in genome instability. Analysis of histone dynamics at sites of replication-coupled chromatin assembly demonstrates that Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly. PMID:23754951

  14. Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.

    PubMed

    Nagarajan, Prabakaran; Ge, Zhongqi; Sirbu, Bianca; Doughty, Cheryl; Agudelo Garcia, Paula A; Schlederer, Michaela; Annunziato, Anthony T; Cortez, David; Kenner, Lukas; Parthun, Mark R

    2013-06-01

    Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the function of this enzyme in a complex organism, we have constructed a conditional mouse knockout model of Hat1. Murine Hat1 is essential for viability, as homozygous deletion of Hat1 results in neonatal lethality. The lungs of embryos and pups genetically deficient in Hat1 were much less mature upon histological evaluation. The neonatal lethality is due to severe defects in lung development that result in less aeration and respiratory distress. Many of the Hat1(-/-) neonates also display significant craniofacial defects with abnormalities in the bones of the skull and jaw. Hat1(-/-) mouse embryonic fibroblasts (MEFs) are defective in cell proliferation and are sensitive to DNA damaging agents. In addition, the Hat1(-/-) MEFs display a marked increase in genome instability. Analysis of histone dynamics at sites of replication-coupled chromatin assembly demonstrates that Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly. PMID:23754951

  15. The arginine repressor is essential for plasmid-stabilizing site-specific recombination at the ColE1 cer locus.

    PubMed Central

    Stirling, C J; Szatmari, G; Stewart, G; Smith, M C; Sherratt, D J

    1988-01-01

    The heritable stability in Escherichia coli of the multicopy plasmid ColE1 and its natural relatives requires that the plasmids be maintained in the monomeric state. Plasmid multimers, that arise through recA-dependent homologous recombination, are normally converted to monomers by a site-specific recombination system that acts at a specific plasmid site (cer in ColE1). No plasmid functions that act at this site have been identified. In contrast, two unlinked E.coli genes that encode functions required for cer-mediated site-specific recombination have been identified. Here we describe the isolation and characterization of one such gene (xerA) and show it to be identical to the gene encoding the repressor of the arginine biosynthetic genes (argR). The argR protein binds to cer DNA both in vivo and in vitro in the presence of arginine. We believe this binding is required to generate a higher order protein-DNA complex within the recombinational synapse. The argR gene of Bacillus subtilis complements an E.coli argR deficiency for cer-mediated recombination despite the two proteins having only 27% amino acid identity. Images PMID:3149585

  16. The BEACH Domain Protein SPIRRIG Is Essential for Arabidopsis Salt Stress Tolerance and Functions as a Regulator of Transcript Stabilization and Localization

    PubMed Central

    Steffens, Alexandra; Bräutigam, Andrea; Jakoby, Marc; Hülskamp, Martin

    2015-01-01

    Members of the highly conserved class of BEACH domain containing proteins (BDCPs) have been established as broad facilitators of protein–protein interactions and membrane dynamics in the context of human diseases like albinism, bleeding diathesis, impaired cellular immunity, cancer predisposition, and neurological dysfunctions. Also, the Arabidopsis thaliana BDCP SPIRRIG (SPI) is important for membrane integrity, as spi mutants exhibit split vacuoles. In this work, we report a novel molecular function of the BDCP SPI in ribonucleoprotein particle formation. We show that SPI interacts with the P-body core component DECAPPING PROTEIN 1 (DCP1), associates to mRNA processing bodies (P-bodies), and regulates their assembly upon salt stress. The finding that spi mutants exhibit salt hypersensitivity suggests that the local function of SPI at P-bodies is of biological relevance. Transcriptome-wide analysis revealed qualitative differences in the salt stress-regulated transcriptional response of Col-0 and spi. We show that SPI regulates the salt stress-dependent post-transcriptional stabilization, cytoplasmic agglomeration, and localization to P-bodies of a subset of salt stress-regulated mRNAs. Finally, we show that the PH-BEACH domains of SPI and its human homolog FAN (Factor Associated with Neutral sphingomyelinase activation) interact with DCP1 isoforms from plants, mammals, and yeast, suggesting the evolutionary conservation of an association of BDCPs and P-bodies. PMID:26133670

  17. Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.

    PubMed

    Tsunoda, Satoshi; Sakurai, Hiroaki; Saito, Yurika; Ueno, Yoko; Koizumi, Keiichi; Saiki, Ikuo

    2009-02-01

    Inflammation in the tumor stroma greatly influences tumor development. In the present study, we investigated the roles of fibroblast growth factor (FGF)-2-induced chronic inflammation in the development of 4T1 murine mammary tumors. Administration of FGF-2 into the tumor inoculation site during the initial phase of tumor growth enhanced tumor growth and pulmonary metastasis as well as microvessel density in tumor tissues in normal but not in nude mice. Infiltration of T lymphocytes and macrophages, recruitment of pericytes/vascular mural cells in neovascular walls, and the expression levels of cyclooxygenase (COX)-2 and vascular endothelial growth factor A (VEGFA) were also enhanced in the FGF-2-activated host stroma of normal mice. In addition, FGF-2-induced tumor growth and metastasis was abrogated by administration of either an immunosuppressant, FK506, or a COX-2 inhibitor. FGF-2 enhanced prostaglandin E(2) secretion in cultured T lymphocytes. In addition, VEGFA secretion was increased in a co-culture of T lymphocytes and fibroblasts in vitro. These results indicate that the massive infiltration of T lymphocytes into FGF-2-activated host stroma during the initial phase of tumor growth enhances neovascular stability by regulating endogenous COX-2 and VEGFA levels because both compounds are known to play important roles in marked 4T1 mammary tumor development via FGF-2-induced inflammatory reactions. PMID:19116363

  18. The BEACH Domain Protein SPIRRIG Is Essential for Arabidopsis Salt Stress Tolerance and Functions as a Regulator of Transcript Stabilization and Localization.

    PubMed

    Steffens, Alexandra; Bräutigam, Andrea; Jakoby, Marc; Hülskamp, Martin

    2015-07-01

    Members of the highly conserved class of BEACH domain containing proteins (BDCPs) have been established as broad facilitators of protein-protein interactions and membrane dynamics in the context of human diseases like albinism, bleeding diathesis, impaired cellular immunity, cancer predisposition, and neurological dysfunctions. Also, the Arabidopsis thaliana BDCP SPIRRIG (SPI) is important for membrane integrity, as spi mutants exhibit split vacuoles. In this work, we report a novel molecular function of the BDCP SPI in ribonucleoprotein particle formation. We show that SPI interacts with the P-body core component DECAPPING PROTEIN 1 (DCP1), associates to mRNA processing bodies (P-bodies), and regulates their assembly upon salt stress. The finding that spi mutants exhibit salt hypersensitivity suggests that the local function of SPI at P-bodies is of biological relevance. Transcriptome-wide analysis revealed qualitative differences in the salt stress-regulated transcriptional response of Col-0 and spi. We show that SPI regulates the salt stress-dependent post-transcriptional stabilization, cytoplasmic agglomeration, and localization to P-bodies of a subset of salt stress-regulated mRNAs. Finally, we show that the PH-BEACH domains of SPI and its human homolog FAN (Factor Associated with Neutral sphingomyelinase activation) interact with DCP1 isoforms from plants, mammals, and yeast, suggesting the evolutionary conservation of an association of BDCPs and P-bodies. PMID:26133670

  19. Medical Issues: Equipment

    MedlinePlus

    ... support & care > living with sma > medical issues > equipment Equipment Individuals with SMA often require a range of ... you can submit an equipment pool request. Helpful Equipment The following is a list of equipment that ...

  20. Essential tremor.

    PubMed Central

    Murray, T. J.

    1981-01-01

    Essential tremor, including the juvenile and senile variations, may be a result of a disorder of the servomechanism that controls physiologic tremor. Hands and arms are affected most commonly, and the tremor can vary in amplitude as well as frequency. Long-term treatment with propranolol has been helpful for some patients, although older patients are less likely to benefit. Other drugs and behaviour modification therapy have been less successful. Surgical treatment is effective but should probably be reserved for severe cases. An effective instrument for measuring the subjective and objective aspects of the tremor is still needed, as is an effective long-term method of treatment. PMID:7018658

  1. 47 CFR 18.211 - Multiple listing of equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Multiple listing of equipment. 18.211 Section 18.211 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INDUSTRIAL, SCIENTIFIC, AND MEDICAL EQUIPMENT Applications and Authorizations § 18.211 Multiple listing of equipment. (a) When the same or essentially the same equipment will...

  2. Common NICU Equipment

    MedlinePlus

    ... care unit (NICU) > Common NICU equipment Common NICU equipment E-mail to a friend Please fill in ... other specialized machines during her NICU stay. What equipment is commonly used in the NICU? Equipment commonly ...

  3. Essential Supersymmetry

    NASA Astrophysics Data System (ADS)

    Polonsky, Nir

    2000-07-01

    Theoretical and experimental motivations, status and prospects of low-energy supersymmetry are discussed. It is shown by explicit construction that the stabilization of any perturbative theory which contains fundamental scalar bosons naturally leads to the notion of supersymmetry. The supersymmetric algebra is briefly described and the resulting constraints on the low-energy theory are emphasized. The minimal supersymmetric extension of the standard model is then pedagogically defined and discussed, and its experimental status is summarized. Dimensionless couplings are extrapolated to high energies and the unification scale is found and interpreted. Renormalization of the models is discussed and the linkage between high and low energies is demonstrated and argued to provide a potential probe of Planck scale physics. Electroweak symmetry breaking is shown to occur dynamically and to successfully predict a heavy t-quark. The low-energy Higgs potential is discussed more generally and special attention is given to the lightest Higgs boson. The upper bound on its mass in minimal and extended models is reviewed and explained. The Higgs mass is shown to provide a crucial test of nearly all supersymmetric theories. Generic low-energy flavor violations (the so-called flavor problem) are described and are used to constrain and classify consistent high-energy models for the s-particle spectrum parameters which softly break supersymmetry at low-energies. Generation of these parameters via tree-level local-supersymmetry interactions (supergravity mediation) or gauge quantum corrections (gauge mediation) is outlined. Possible lepton-number violation and scenarios for neutrino mass generation are also described.

  4. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... that it does not cause essential loads to become inoperative as a result of electrical power supply... electronic equipment must be supplied with power under the requirements of § 25.1355(c). (c) Radio...

  5. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... that it does not cause essential loads to become inoperative as a result of electrical power supply... electronic equipment must be supplied with power under the requirements of § 25.1355(c). (c) Radio...

  6. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... that it does not cause essential loads to become inoperative as a result of electrical power supply... electronic equipment must be supplied with power under the requirements of § 25.1355(c). (c) Radio...

  7. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... that it does not cause essential loads to become inoperative as a result of electrical power supply... electronic equipment must be supplied with power under the requirements of § 25.1355(c). (c) Radio...

  8. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... that it does not cause essential loads to become inoperative as a result of electrical power supply... electronic equipment must be supplied with power under the requirements of § 25.1355(c). (c) Radio...

  9. Essential thrombocythemia

    PubMed Central

    Brière, Jean B

    2007-01-01

    Essential thrombocythemia (ET) is an acquired myeloproliferative disorder (MPD) characterized by a sustained elevation of platelet number with a tendency for thrombosis and hemorrhage. The prevalence in the general population is approximately 30/100,000. The median age at diagnosis is 65 to 70 years, but the disease may occur at any age. The female to male ratio is about 2:1. The clinical picture is dominated by a predisposition to vascular occlusive events (involving the cerebrovascular, coronary and peripheral circulation) and hemorrhages. Some patients with ET are asymptomatic, others may experience vasomotor (headaches, visual disturbances, lightheadedness, atypical chest pain, distal paresthesias, erythromelalgia), thrombotic, or hemorrhagic disturbances. Arterial and venous thromboses, as well as platelet-mediated transient occlusions of the microcirculation and bleeding, represent the main risks for ET patients. Thromboses of large arteries represent a major cause of mortality associated with ET or can induce severe neurological, cardiac or peripheral artery manifestations. Acute leukemia or myelodysplasia represent only rare and frequently later-onset events. The molecular pathogenesis of ET, which leads to the overproduction of mature blood cells, is similar to that found in other clonal MPDs such as chronic myeloid leukemia, polycythemia vera and myelofibrosis with myeloid metaplasia of the spleen. Polycythemia vera, myelofibrosis with myeloid metaplasia of the spleen and ET are generally associated under the common denomination of Philadelphia (Ph)-negative MPDs. Despite the recent identification of the JAK2 V617F mutation in a subset of patients with Ph-negative MPDs, the detailed pathogenetic mechanism is still a matter of discussion. Therapeutic interventions in ET are limited to decisions concerning the introduction of anti-aggregation therapy and/or starting platelet cytoreduction. The therapeutic value of hydroxycarbamide and aspirin in high risk patients has been supported by controlled studies. Avoiding thromboreduction or opting for anagrelide to postpone the long-term side effects of hydrocarbamide in young or low risk patients represent alternative options. Life expectancy is almost normal and similar to that of a healthy population matched by age and sex. PMID:17210076

  10. Aquatic Equipment Information.

    ERIC Educational Resources Information Center

    Sova, Ruth

    Equipment usually used in water exercise programs is designed for variety, intensity, and program necessity. This guide discusses aquatic equipment under the following headings: (1) equipment design; (2) equipment principles; (3) precautions and contraindications; (4) population contraindications; and (5) choosing equipment. Equipment is used…

  11. Longitudinal Stability and Control Characteristics at Mach Numbers from 0.70 to 2.22 of a Triangular Wing Configuration Equipped with a Canard Control, a Trailing-Edge-Flap Control or a Cambered Forebody

    NASA Technical Reports Server (NTRS)

    Boyd, John W.; Menees, Gene P.

    1959-01-01

    Results of an investigation to determine the static longitudinal stability and control characteristics of an aspect-ratio-2 triangular wing and body configuration equipped with either a canard control, a trailing-edge-flap control, or a cambered forebody are presented without analysis for Mach numbers from 0.70 to 2.22. The canard surface had a triangular plan form and a ratio of exposed area to total wing area of 7.8 percent. The hinge line of the canard was in the extended wing chord plane, 0.83 wing mean aerodynamic chord ahead of the reference center of moments. The trailing-edge controls were constant-chord full-span flaps with exposed area equal to 10.7 percent of the total wing area. The cambered body was a modified Sears-Haack body with camber only ahead of the wing apex. Data are presented for various canard and flap deflections at angles of attack ranging from -6 deg to +18 deg.

  12. [A waterproof equipment for endoscope equipment].

    PubMed

    Huang, Wanchao; Qiao, Tie; He, Qunzhi; Xie, Jingxia

    2010-07-01

    The article introduces a new kind of waterproof equipment for endoscope. The equipment can resolve the problem that the endoscope's ocular and camera are always interfered by the Backstreaming liquid while performing surgical operation. The equipment is made up of three parts, which are ring-shaped locking structure, obturating ring and waterproof plastic sheath. Using the equipment can achieve the purpose of protecting the endoscope's ocular and camera effectively. PMID:21033115

  13. Gene expression of heat shock protein 70 and antioxidant enzymes, oxidative status, and meat oxidative stability of cyclically heat-challenged finishing broilers fed Origanum compactum and Curcuma xanthorrhiza essential oils.

    PubMed

    Akbarian, A; Michiels, J; Golian, A; Buyse, J; Wang, Y; De Smet, S

    2014-08-01

    Heat stress in poultry is a serious problem in many countries and has been associated with oxidative stress. Hence, nutritional interventions with antioxidants might be beneficial. Therefore, the effects of dietary Curcuma xanthorrhiza (CX) and Origanum compactum (OC) essential oils on mRNA levels of heat shock protein 70 and antioxidant enzymes, oxidative status, and meat oxidative stability of heat-challenged broilers were studied. Starting on d 25 of age, a control diet and 4 diets containing 200 or 400 mg/kg feed of CX or OC (CX200, CX400, OC200, OC400 diets) were fed to 3 pen replicates of 20 Ross 308 chickens each. From d 28 of age on, the temperature was increased from 22 to 34°C with 50% RH for 5 h daily during 2 wk. Dietary CX or OC did not affect zootechnical performance. Feeding CX400 and both levels of OC increased the a* value in stored breast meat (P < 0.05), and OC diets tended to decrease the thiobarbituric acid reactive substances values in fresh breast meat (P = 0.061). Compared with control, at d 31, feeding CX400 and OC400 reduced mRNA levels of heat shock protein 70 and increased mRNA levels of catalase in kidney and liver (P < 0.05). The mRNA levels of superoxide dismutase were increased at d 31 on the OC400 diet in kidney and on the CX400 diet in heart (P < 0.05). In heart, at d 31, both dietary levels of CX and OC200 resulted in higher glutathione peroxidase activity (P < 0.05). Feeding CX400 increased superoxide dismutase activity in liver, kidney, and heart at d 31 (P < 0.05). Catalase activity was increased in the CX200 and OC400 groups at d 42 (P < 0.05). Feeding CX at both levels and OC200 decreased plasma malondialdehyde concentrations at d 42 (P < 0.05). In conclusion, dietary essential oils rich in simple phenolic compounds offer potential for improving the antioxidant defense against heat stress-induced changes. PMID:24931966

  14. [Antioxidant properties of essential oils].

    PubMed

    Misharina, T A; Terenina, M B; Krikunova, N I

    2009-01-01

    By the method of capillary gas-liquid chromatography we studied antioxidant properties and stability during the storage of hexane solutions of 14 individual essential oils from black and white pepper (Piper nigrum L.), cardamom (Elettaria cardamomum L.), nutmeg (Myristica fragrans Houtt.), mace (Myristica fragrans Houtt), juniperberry (Juniperus communis L.), seed of fennel (Foeniculum vulgare Mill., var. dulce Thelling), caraway (Carvum carvi L.), dry leaves of cinnamon (Cinnamomum zeylanicum Bl.), marjoram (Origanum majorana L.), laurel (Laurus nobilis L.), ginger (Zingiber officinale L.), garlic (Allium sativum L.), and clove bud (Caryophyllus aromaticus L.). We assessed the antioxidant properties by the oxidation of aliphatic aldehyde (trans-2-hexenal) into the according carbon acid. We established that essential oils of garlic, clove bud, ginger and leaves of cinnamon have the maximal efficiency of inhibition of hexenal oxidation (80-93%), while black pepper oil has the minimal (49%). Antioxidant properties of essential oils with a high content of substituted phenols depended poorly on its concentration in model systems. We studied the changes in essential oils content during the storage of its hexane solutions for 40 days in the light and out of the light and compared it with the stability of essential oils stored for a year out of the light. PMID:20067158

  15. Maintenance program guidelines for programmatic equipment

    SciTech Connect

    Not Available

    1994-11-01

    The Division Directors at Lawrence Berkeley Laboratory are responsible for implementing a maintenance program for research equipment (also referred to as programmatic equipment) assigned to them. The program must allow maintenance to be accomplished in a manner that promotes operational safety, environmental protection and compliance, and cost effectiveness; that preserves the intended functions of the facilities and equipment; and that supports the programmatic mission of the Laboratory. Programmatic equipment -- such as accelerators, lasers, radiation detection equipment, and glove boxes -- is dedicated specifically to research. Installed equipment, by contrast, includes the mechanical and electrical systems installed as part of basic building construction, equipment essential to the normal functioning of the facility and its intended use. Examples of installed equipment are heating, ventilating, and air conditioning systems; elevators; and communications systems. The LBL Operating and Assurance Program Plan (PUB-3111, Revision 4) requires that a maintenance program be prepared for programmatic equipment and defines the basic maintenance program elements. Such a program of regular, documented maintenance is vital to the safety and quality of research activities. As a part of that support, this document offers guidance to Laboratory organizations for developing their maintenance programs. It clarifies the maintenance requirements of the Operating and Assurance Program (OAP) and presents an approach that, while not the only possibility, can be expected to produce an effective maintenance program for research equipment belonging to the Laboratory`s organizations.

  16. Cleaning supplies and equipment

    MedlinePlus

    ... on any object the person touched or on equipment that was used during their care. Some germs ... why it is important to disinfect supplies and equipment. To disinfect something means to clean it to ...

  17. Equipment for Microgravity Research

    NASA Technical Reports Server (NTRS)

    Fountain, J. A.

    1986-01-01

    Illustrated catalog describes equipment and facilities available for experiments under low-gravity conditions. Catalog encourages scientific and commercial organizations to investigate benefits of conducting research and manufacturing activities in microgravity environment. Catalog covers equipment ranging from containers to spacecraft.

  18. Water-Using Equipment: Commercial and Industrial

    SciTech Connect

    Solana, Amy E.; Mcmordie, Katherine

    2006-01-24

    Water is an important aspect of many facets in energy engineering. While the previous article detailed domestic related water-using equipment such as toilets and showerheads, this article focuses on various types of water-using equipment in commercial and industrial facilities, including commercial dishwashers and laundry, single-pass cooling equipment, boilers and steam generators, cooling towers, and landscape irrigation. Opportunities for water and energy conservation are explained, including both technology retrofits and operation and maintenance changes. Water management planning and leak detection are also included as they are essential to a successful water management program.

  19. Microform Retrieval Equipment Guide.

    ERIC Educational Resources Information Center

    National Archives and Records Service (GSA), Washington, DC. Office of Records Management.

    A basis for comparing available equipment against the requirements of the prospective user or purchaser of microform retrieval equipment is provided. As used in the handbook, microform retrieval equipment is defined as any device that is used to locate, enlarge, and display microform images or that produces enlarged hard copy from the images. Only

  20. Mobile Equipment Expands Inventory.

    ERIC Educational Resources Information Center

    McGough, Robert L.; And Others

    1978-01-01

    Describes the Mobile Equipment Modules (MEM) system in Duluth, Minnesota. MEM is a way to hold down costs and increase learning opportunities by consolidating purchases of expensive shop equipment within the school district, grouping the equipment in modules, and scheduling and moving it from school to school as needed. (MF)

  1. Drawing evaluation report for sampling equipment drawings

    SciTech Connect

    WILSON, G.W.

    1999-05-24

    This document presents the results of a task to evaluate Tank Waste Remediation System (TWRS) sampling equipment drawings and identifies drawings category as either essential, support, or general drawings. This report completes the drawing evaluation task as outlined in Engineering Task Plan For Truck 3 and 4 Drawing Compliance and Evaluation (Wilson, 1997). The scope of this report is limited to an evaluation and identification of drawing category for drawings of certain tank waste sampling equipment for which the TRWS Characterization Project has been assigned custody, including: vapor sampling, grab sampling, auger sampling, and all core sampling equipment (see LMHC Task Order 304). This report does not address drawings for other waste tank deployed equipment systems having similar assigned custody, such as, Light Duty Utility Arm (LDUA), Cone Penetrometer system, or Long Length Contaminated Equipment (LLCE). The LDUA drawings are addressed in the Characterization Equipment Essential Drawings (HNF 1998). The Cone Penetrometer system drawings which are vendor drawings (not H- series) is not currently turned over to operations for deployment. The LLCE equipment was just recently assigned to Characterization Project and were not included in the original scope for this evaluation and will be addressed in the evaluation update scheduled for fiscal year 1999.

  2. Essential Laboratory Activities Guide. Secondary Science.

    ERIC Educational Resources Information Center

    Duval County Schools, Jacksonville, FL.

    This teacher's guide was developed for use in junior and senior high schools in Duval County, Jacksonville, Florida, for the purpose of identifying those secondary science laboratory experiences which are essential to the development of science content knowledge and competency in handling science laboratory equipment and consumables. The guide

  3. 10 proven strategies for reducing equipment costs.

    PubMed

    Henley, Richard J; Zimmerman, Martin A

    2005-05-01

    It is essential to consider your organization's equipment acquisitions in light of your business strategy. In negotiating the financing, share your business objectives with a preferred list of financing sources that can be counted on to recommend alternatives in addition to quoting on the specified financing. PMID:15938353

  4. RETRIEVAL EQUIPMENT DESCRIPTIONS

    SciTech Connect

    J. Steinhoff

    1997-08-25

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) retrieval from the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. There are no quality assurance requirements or QA controls in this document. Retrieval under normal conditions is accomplished with the same fleet of equipment as is used for emplacement. Descriptions of equipment used for retrieval under normal conditions is found in Emplacement Equipment Descriptions, DI: BCAF00000-01717-5705-00002 (a document in progress). Equipment used for retrieval under abnormal conditions is addressed in this document and consists of the following: (1) Inclined Plane Hauler; (2) Bottom Lift Transporter; (3) Load Haul Dump (LHD) Loader; (4) Heavy Duty Forklift for Emplacement Drifts; (5) Covered Shuttle Car; (6) Multipurpose Vehicle; and (7) Scaler.

  5. Selecting WP Equipment.

    ERIC Educational Resources Information Center

    Casady, Mona J.

    1981-01-01

    Suggestions for schools considering the purchase of word processing equipment are presented. Procedures for selecting equipment include getting information on prices, servicing, warranties, training, speed of printing, and quality of output. Choices to make include brand vs. service, price vs. service, and variety vs. limitations of brands. (CT)

  6. Engineer Equipment Mechanic.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    Developed as part of the Marine Corps Institute (MCI) correspondence training program, this course on engineer equipment mechanics is designed to advance the professional competence of privates through sergeants as equipment mechanics, Military Occupation Specialty 1341, and is adaptable for nonmilitary instruction. Introductory materials include…

  7. Equipment Operator 1 & C.

    ERIC Educational Resources Information Center

    Naval Education and Training Program Development Center, Pensacola, FL.

    The Rate Training Manual and Nonresident Career Course (RTM/NRCC) form a self-study package to assist Navy Equipment Operators First and Chief in fulfilling the requirements of their rating. (Navy Equipment Operators First and Chief direct and coordinate efforts of individuals and crews in construction, earthmoving, roadbuilding, quarrying, and…

  8. Equipment Operator 1 & C.

    ERIC Educational Resources Information Center

    Naval Education and Training Program Development Center, Pensacola, FL.

    The Rate Training Manual and Nonresident Career Course (RTM/NRCC) form a self-study package to assist Navy Equipment Operators First and Chief in fulfilling the requirements of their rating. (Navy Equipment Operators First and Chief direct and coordinate efforts of individuals and crews in construction, earthmoving, roadbuilding, quarrying, and

  9. Troubleshooting rotating equipment

    SciTech Connect

    Wong, R.F. )

    1992-10-01

    This paper reports that equipment problems in a Peruvian refinery illustrate the process engineer's role as a troubleshooter. Examples show that rotating equipment problems can stem from mechanical or process factors and involve both inspection/maintenance specialists and process engineers.

  10. Shipboard Electronic Equipments.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    Fundamentals of major electronic equipments on board ships are presented in this text prepared for naval officers in general. Basic radio principles are discussed in connection with various types of transmitters, receivers, antennas, couplers, transfer panels, remote-control units, frequency standard equipments, teletypewriters, and facsimile…

  11. Equipment & New Products.

    ERIC Educational Resources Information Center

    Poitras, Adrian W., Ed.

    1977-01-01

    Presents several new products and equipment for teaching college science courses such as laser optics bench, portable digital thermometer, solar energy furnaces and blackboard optics kit. A description of all equipment or products, cost, and addresses of manufacturers are also included. (HM)

  12. Drawing Evaluation Report for Sampling Equipment

    SciTech Connect

    BOGER, R.M.

    1999-09-09

    This document presents the results of a task to update the evaluation of River Protection Project (WP) sampling equipment drawings and updates the assigned drawings category as either essential, support, or general drawings. This report updates the drawing evaluation that was originally done per Engineering Task Plan For Truck 3 & 4 Drawing Compliance and Evaluation. The scope of this report is limited to updating the evaluation and identification of drawing category for drawings of certain tank waste sampling equipment for which the RPP Characterization Project has been assigned custody, including: vapor sampling, grab sampling, auger sampling, all core sampling equipment, and Light Duty Utility Arm (LDUA) (see LMHC contract No. 519, release 10). This report does not address drawings for other waste tank deployed equipment systems having similar assigned custody, such as, Cone Penetrometer system, or Long Length Contaminated Equipment (LLCE). The Cone Penetrometer system, which is depicted on vendor drawings, (not H- series), is not currently turned over to operations for deployment. The LLCE equipment was just recently assigned to Characterization Project and was not included in the original scope for this update and will be addressed in the evaluation update scheduled for later in fiscal year 1999, when equipment ownership is determined.

  13. Heavy Equipment. Trade and Industrial Education Trade Preparatory Training Guide.

    ERIC Educational Resources Information Center

    Nebraska State Dept. of Education, Lincoln. Div. of Vocational Education.

    One of a series of curriculum guides prepared for the building occupations cluster of the construction/fabrication occupational group, this guide identifies the essentials of the heavy equipment trade as recommended by the successful heavy equipment operator. An instructional program based upon the implementation of the guide is expected to…

  14. Magnetotelluric Equipment Installation

    USGS scientist, Jared Peacock making sure the equipment is set up properly with good data coming in, and programming the data logger to collect magnetotelluric data for 24 hours as NAGT intern, Monica Mustain looks on....

  15. Equipment & New Products.

    ERIC Educational Resources Information Center

    Poitras, Adrian W., Ed.

    1979-01-01

    Reviews new science equipment and products for the laboratory. Includes hand-held calculators, fiberglass fume hoods, motorized microtomy, disposable mouse cages, and electric timers. Describes 11 products total. Provides manufacturer name, address, and price. (MA)

  16. Listing of Food Service Equipment.

    ERIC Educational Resources Information Center

    National Sanitation Foundation, Ann Arbor, MI. Testing Lab.

    A comprehensive listing of food service equipment including--(1) companies authorized to use the National Sanitation Foundation seal of approval, and (2) equipment listed as meeting NSF standards including soda fountains, spray-type dishwashers, dishwashing equipment, cooking equipment, commerical cooking and warming equipment, freezers,…

  17. Development of medical equipment alarm monitoring system.

    PubMed

    Yamashita, Yoshinori; Ogaito, Tatoku; Kasamatsu, Shingo

    2013-01-01

    In a hospital, we use a large number of medical equipment. In these use, I support the safe use by the alarm such as errors from medical equipment. There is the instrument notifying of alarm in communication, but there is the instrument by a sound and the light. For the medical safety management, confirmation of the alarm is important. We thought that stability was improved by integrating alarm from the instrument of the different type. Therefore, we thought that we integrated alarm from medical equipment. We decided to transmit an alarm signal from medical equipment by adding radio module program unit. The type of the radio used IEEE 802.15.4 (ZigBee) at a point of view of low power, International Standard, simple radio equipment. This system deals with only alarm information from medical equipment and does not handle the data. However, we understood that we were helpful very much even if it was only alarm information. We were able to in this way reduce the number of incidents. PMID:23920969

  18. Wellhead equipment support

    SciTech Connect

    Nichols, R.P.

    1987-03-24

    A wellhead assembly is described for supporting equipment in a well, comprising: a suspension nut having a threaded outer surface; a wellhead member having an inner threaded surface adapted to mesh with the threaded outer surface of the suspension nut; the suspension nut having a projection extending axially from its threaded outer surface and having an inner surface adapted to support equipment in the well; at least a portion of the inner surface for supporting the equipment facing both inwardly and upwardly such that force exerted by the weight of the equipment against the inner surface is transformed at least in part to a radially outwardly directed force; the projecting having an outer surface sized such that the outer surface is spaced from an inner surface of the wellhead member in the absence of force exerted against the inner surface of the projection such that the projection is deflected outwardly by the force exerted by the weight of the equipment against the inner surface.

  19. About Personal Protective Equipment (PPE)

    MedlinePlus

    ... Equipment for Infection Control Questions About Personal Protective Equipment (PPE) Share Tweet Linkedin Pin it More sharing ... Print Q1. How do manufacturers ensure personal protective equipment (PPE) is safe and effective? A1. To help ...

  20. [Medical Equipment Maintenance Methods].

    PubMed

    Liu, Hongbin

    2015-09-01

    Due to the high technology and the complexity of medical equipment, as well as to the safety and effectiveness, it determines the high requirements of the medical equipment maintenance work. This paper introduces some basic methods of medical instrument maintenance, including fault tree analysis, node method and exclusive method which are the three important methods in the medical equipment maintenance, through using these three methods for the instruments that have circuit drawings, hardware breakdown maintenance can be done easily. And this paper introduces the processing methods of some special fault conditions, in order to reduce little detours in meeting the same problems. Learning is very important for stuff just engaged in this area. PMID:26904890

  1. Treatment of Essential Tremor

    MedlinePlus

    ... Two types of brain surgery, deep brain stimulation (DBS) and thalamotomy, are used to treat essential tremor. ... of nerve cells deep in the brain. In DBS, an electric probe (electrode) is placed in the ...

  2. Equipment Operational Requirements

    SciTech Connect

    Greenwalt, B; Henderer, B; Hibbard, W; Mercer, M

    2009-06-11

    The Iraq Department of Border Enforcement is rich in personnel, but poor in equipment. An effective border control system must include detection, discrimination, decision, tracking and interdiction, capture, identification, and disposition. An equipment solution that addresses only a part of this will not succeed, likewise equipment by itself is not the answer without considering the personnel and how they would employ the equipment. The solution should take advantage of the existing in-place system and address all of the critical functions. The solutions are envisioned as being implemented in a phased manner, where Solution 1 is followed by Solution 2 and eventually by Solution 3. This allows adequate time for training and gaining operational experience for successively more complex equipment. Detailed descriptions of the components follow the solution descriptions. Solution 1 - This solution is based on changes to CONOPs, and does not have a technology component. It consists of observers at the forts and annexes, forward patrols along the swamp edge, in depth patrols approximately 10 kilometers inland from the swamp, and checkpoints on major roads. Solution 2 - This solution adds a ground sensor array to the Solution 1 system. Solution 3 - This solution is based around installing a radar/video camera system on each fort. It employs the CONOPS from Solution 1, but uses minimal ground sensors deployed only in areas with poor radar/video camera coverage (such as canals and streams shielded by vegetation), or by roads covered by radar but outside the range of the radar associated cameras. This document provides broad operational requirements for major equipment components along with sufficient operational details to allow the technical community to identify potential hardware candidates. Continuing analysis will develop quantities required and more detailed tactics, techniques, and procedures.

  3. Equipment Management Manual

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The NASA Equipment Management Manual (NHB 4200.1) is issued pursuant to Section 203(c)(1) of the National Aeronautics and Space Act of 1958, as amended (42 USC 2473), and sets forth policy, uniform performance standards, and procedural guidance to NASA personnel for the acquisition, management, and use of NASA-owned equipment. This revision is effective upon receipt. This is a controlled manual, issued in loose-leaf form, and revised through page changes. Additional copies for internal use may be obtained through normal distribution.

  4. Artifacts and essentialism

    PubMed Central

    Gelman, Susan A.

    2013-01-01

    Psychological essentialism is an intuitive folk belief positing that certain categories have a non-obvious inner “essence” that gives rise to observable features. Although this belief most commonly characterizes natural kind categories, I argue that psychological essentialism can also be extended in important ways to artifact concepts. Specifically, concepts of individual artifacts include the non-obvious feature of object history, which is evident when making judgments regarding authenticity and ownership. Classic examples include famous works of art (e.g., the Mona Lisa is authentic because of its provenance), but ordinary artifacts likewise receive value from their history (e.g., a worn and tattered blanket may have special value if it was one's childhood possession). Moreover, in some cases, object history may be thought to have causal effects on individual artifacts, much as an animal essence has causal effects. I review empirical support for these claims and consider the implications for both artifact concepts and essentialism. This perspective suggests that artifact concepts cannot be contained in a theoretical framework that focuses exclusively on similarity or even function. Furthermore, although there are significant differences between essentialism of natural kinds and essentialism of artifact individuals, the commonalities suggest that psychological essentialism may not derive from folk biology but instead may reflect more domain-general perspectives on the world. PMID:23976903

  5. Artifacts and essentialism.

    PubMed

    Gelman, Susan A

    2013-09-01

    Psychological essentialism is an intuitive folk belief positing that certain categories have a non-obvious inner "essence" that gives rise to observable features. Although this belief most commonly characterizes natural kind categories, I argue that psychological essentialism can also be extended in important ways to artifact concepts. Specifically, concepts of individual artifacts include the non-obvious feature of object history, which is evident when making judgments regarding authenticity and ownership. Classic examples include famous works of art (e.g., the Mona Lisa is authentic because of its provenance), but ordinary artifacts likewise receive value from their history (e.g., a worn and tattered blanket may have special value if it was one's childhood possession). Moreover, in some cases, object history may be thought to have causal effects on individual artifacts, much as an animal essence has causal effects. I review empirical support for these claims and consider the implications for both artifact concepts and essentialism. This perspective suggests that artifact concepts cannot be contained in a theoretical framework that focuses exclusively on similarity or even function. Furthermore, although there are significant differences between essentialism of natural kinds and essentialism of artifact individuals, the commonalities suggest that psychological essentialism may not derive from folk biology but instead may reflect more domain-general perspectives on the world. PMID:23976903

  6. Chromium and Genomic Stability

    PubMed Central

    Wise, Sandra S.; Wise, John Pierce

    2014-01-01

    Many metals serve as micronutrients which protect against genomic instability. Chromium is most abundant in its trivalent and hexavalent forms. Trivalent chromium has historically been considered an essential element, though recent data indicate that while it can have pharmacological effects and value, it is not essential. There are no data indicating that trivalent chromium promotes genomic stability and, instead may promote genomic instability. Hexavalent chromium is widely accepted as highly toxic and carcinogenic with no nutritional value. Recent data indicate that it causes genomic instability and also has no role in promoting genomic stability. PMID:22192535

  7. Lennox - Student Training Equipment.

    ERIC Educational Resources Information Center

    Lennox Industries, Inc., Marshalltown, IA.

    Presents a series of demonstration units designed by Lennox Industries for the purpose of training students to become familiar with Lennox mechanical equipment. Demonstrators are designed to present technical information in a clear simplified manner thus reducing frustration for the beginning trainee. The following demonstrators are available--(1)…

  8. Engineer Equipment Operator.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the skills needed by engineer equipment operators. Addressed in the seven individual units of the course are the following topics: introduction to Military Occupation Specialty (MOS) 1345…

  9. Dairy Equipment Lubrication

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Lake To Lake Dairy Cooperative, Manitowoc, Wisconsin, operates four plants in Wisconsin for processing milk, butter and cheese products from its 1,300 member farms. The large co-op was able to realize substantial savings by using NASA information for improved efficiency in plant maintenance. Under contract to Marshall Space Flight Center, Midwest Research Institute compiled a handbook consolidating information about commercially available lubricants. The handbook details chemical and physical properties, applications, specifications, test procedures and test data for liquid and solid lubricants. Lake To Lake's plant engineer used the handbook to effect savings in maintenance labor and materials costs by reducing the number of lubricants used on certain equipment. Strict U.S. Department of Agriculture and Food and Drug Administration regulations preclude lubrication changes n production equipment, but the co-op's maintenance chief was able to eliminate seven types of lubricants for ancillary equipment, such as compressors and high pressure pumps. Handbook data enabled him to select comparable but les expensive lubricants in the materials consolidation process, and simplified lubrication schedules and procedures. The handbook is in continuing use as a reference source when a new item of equipment is purchased.

  10. The EQUIP Program

    ERIC Educational Resources Information Center

    Gibbs, John C.; Potter, Granville Bud; DiBiase, Ann-Marie; Devlin, Renee

    2008-01-01

    Youth who present anti-social behavior need powerful interventions that strengthen empathy, counter negative peer influence, and challenge thinking errors. This article recaps some key points about EQUIP, a Positive Peer Culture (PPC)-based cognitive behavioral intervention program for behaviorally at-risk youth, and notes how the program has…

  11. Equipment & New Products.

    ERIC Educational Resources Information Center

    Poitras, Adrian W., Ed.

    1977-01-01

    Presents information about equipment and new products such as the melting point instrument and TV-microscope coupler which are helpful in college science teaching. Descriptions of each product, how it operates, its prices, and address for ordering are presented. (HM)

  12. Engineer Equipment Chief.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the skills needed by engineer equipment chiefs. Addressed in the five individual units of the course are the following topics: construction management (planning, scheduling, and supervision);…

  13. Equipment & New Products.

    ERIC Educational Resources Information Center

    Poitras, Adrian W., Ed.

    1977-01-01

    Identifies several pieces of equipment and new products for use in college science teaching such as: (1)rotary retracting microtome; (2)airflow bench; and (3)digital stop clock. A description of each one, the price, and the address of the seller are also presented. (HM)

  14. STDN ranging equipment

    NASA Technical Reports Server (NTRS)

    Jones, C. E.

    1975-01-01

    Final results of the Spaceflight Tracking and Data Network (STDN) Ranging Equipment program are summarized. Basic design concepts and final design approaches are described. Theoretical analyses which define requirements and support the design approaches are presented. Design verification criteria are delineated and verification test results are specified.

  15. Basic Engineer Equipment Mechanic.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the skills needed by basic engineer equipment mechanics. Addressed in the four individual units of the course are the following topics: mechanics and their tools (mechanics, hand tools, and power…

  16. Photographic Equipment Field Maintenance

    NASA Astrophysics Data System (ADS)

    Endelman, Lincoln L.

    1982-02-01

    Dust, moisture, insects, rodents, explosives and cleaning solutions are among the major problems that cause equipment failure. There are others; improper use, abuse, aging and disasters, but this paper deals with those methods that will keep a camera system operating by properly maintaining it.

  17. Remote maintenance lessons learned'' on prototypical reprocessing equipment

    SciTech Connect

    Kring, C.T.; Schrock, S.L.

    1990-01-01

    Hardware representative of essentially every major equipment item necessary for reprocessing breeder reactor nuclear fuel has been installed and tested for remote maintainability. This testing took place in a cold mock-up of a remotely maintained hot cell operated by the Consolidated Fuel Reprocessing Program (CFRP) within the Fuel Recycle Division at Oak Ridge National Laboratory (ORNL). The reprocessing equipment tested included a Disassembly System, a Shear System, a Dissolver System, an Automated Sampler System, removable Equipment Racks on which various chemical process equipment items were mounted, and an advanced servomanipulator (ASM). These equipment items were disassembled and reassembled remotely by using the remote handling systems that are available within the cold mock-up area. This paper summarizes the lessons learned'' as a result of the numerous maintenance activities associated with each of these equipment items. 4 refs., 3 figs., 1 tab.

  18. Orbiter based construction equipment

    NASA Astrophysics Data System (ADS)

    Goodwin, C. J.

    1982-03-01

    Many orbiter based activities need equipment to hold a payload steady while it is being worked on. This work may be construction, updating, repair, services, check out, or refueling operations in preparation for return to Earth. The Handling and Positioning Aid (HPA) is intended for use as general purpose equipment. The HPA provides a wide choice of work station positions, both immediately above the orbiter cargo bay and beyond. It can act in a primary docking role and, if required, can assist actively in the berthing process. From an analysis of ten reference missions, it was determined that two types of HPA mobility are needed; a tilt table, which simply swings out of the cargo bay, pivoting about an athwartships y axis, and an articulated arm. Illustration of the aid are provided.

  19. HVAC equipment and noise

    SciTech Connect

    Cerami, V.J.

    1996-03-01

    The purpose of this article is to define how the selection of HVAC equipment and layout impact the achievable noise criteria (NC) levels in occupied spaces. It will focus on the design of HVAC systems that employ floor-by-floor air handling/air conditioning units and their acoustical ramifications. This is of increasing importance since tenants require incorporation of noise limits in lease agreements.

  20. Equipment Failure Analysis

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Tennessee Eastman uses NASTRAN to minimize lost production by pinpointing the causes of equipment failures and preventing recurrences. An example of the program's utility involves a large centrifugal fan which developed cracks during start-ups and shutdowns. This information prompted redesign of the fan. Tennessee Eastman has made extensive use of NASTRAN, both as failure analysis tool and as an aid in redesigning production hardware.

  1. [Zinc: an essential oligoelement].

    PubMed

    Rubio, C; González Weller, D; Martín-Izquierdo, R E; Revert, C; Rodríguez, I; Hardisson, A

    2007-01-01

    This article comprehensively reviews zinc, the metallic element essential for body functioning. We review and highlight issues related to pharmacokinetics, the most important dietary sources, as well as its RDIs (Recommended Dietary Intakes). We also focus on signs and symptoms related with both a deficient intake and possible toxic effects derived from excessive intakes. PMID:17260538

  2. Physical Education: Essential Issues

    ERIC Educational Resources Information Center

    Green, Ken, Ed.; Hardman, Ken, Ed.

    2005-01-01

    This book is aimed primarily at under and postgraduate students pursuing entire programmes or discrete courses and modules in the broad area of physical education and sport in schools. It consists of a collection of what is considered to be essential readings in the sense that they are contributions from eminent authors on a breadth of salient…

  3. 47 CFR 22.863 - Frequency stability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Frequency stability. 22.863 Section 22.863...-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.863 Frequency stability. The frequency stability of equipment used under this subpart shall be sufficient to ensure that,...

  4. 47 CFR 22.863 - Frequency stability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Frequency stability. 22.863 Section 22.863...-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.863 Frequency stability. The frequency stability of equipment used under this subpart shall be sufficient to ensure that,...

  5. 47 CFR 22.863 - Frequency stability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Frequency stability. 22.863 Section 22.863...-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.863 Frequency stability. The frequency stability of equipment used under this subpart shall be sufficient to ensure that,...

  6. 47 CFR 22.863 - Frequency stability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Frequency stability. 22.863 Section 22.863...-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.863 Frequency stability. The frequency stability of equipment used under this subpart shall be sufficient to ensure that,...

  7. 47 CFR 22.863 - Frequency stability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Frequency stability. 22.863 Section 22.863...-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.863 Frequency stability. The frequency stability of equipment used under this subpart shall be sufficient to ensure that,...

  8. 8. CONTROL AND EQUIPMENT ROOM INTERIOR. MECHANICAL EQUIPMENT ROOM AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. CONTROL AND EQUIPMENT ROOM INTERIOR. MECHANICAL EQUIPMENT ROOM AT RIGHT AND ENTRANCE AT LEFT. Looking east. - Edwards Air Force Base, South Base Sled Track, Firing Control Blockhouse, South of Sled Track at east end, Lancaster, Los Angeles County, CA

  9. 12. VIEW OF REMOTELY OPERATED EQUIPMENT. OPERATORS VIEWED THE EQUIPMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF REMOTELY OPERATED EQUIPMENT. OPERATORS VIEWED THE EQUIPMENT THROUGH A WATER-FILLED WINDOW. (10/8/81) - Rocky Flats Plant, Plutonium Recovery Facility, Northwest portion of Rocky Flats Plant, Golden, Jefferson County, CO

  10. Stabilized Zeeman split laser

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The development of a stablized Zeeman split laser for use in a polarization profilometer is discussed. A Hewlett-Packard laser was modified to stabilize the Zeeman split beat frequency thereby increasing the phase measurement accuracy from the Hewlett-Packard 3 degrees to an accuracy of .01 degrees. The addition of a two layered inductive winding converts the laser to a current controlled oscillator whose frequency is linearly related to coil current. This linear relationship between coil current and laser frequency permits phase locking the laser frequency to a stable crystal controlled reference frequency. The stability of the system is examined and the equipment operation procedures are outlined.

  11. Essentials of biochemistry

    SciTech Connect

    Schumm, D.E.; Davis, F.A.

    1987-01-01

    This text covers the major areas of medical biochemistry with emphasis on reviewing essentials. It differs from most existing biochemistry texts by including such topics as nutrition and mechanisms of drug action and employing an easy-to-read narrative style that allows coverage to be simultaneously comprehensive and concise. Contents include: introduction to the cell; molecular biology; proteins, carbohydrate metabolism; central pathways; lipids; amino acids; nucleotides; and integration of metabolism.

  12. Pharmacotherapy of Essential Tremor

    PubMed Central

    Hedera, Peter; Cibulčík, František; Davis, Thomas L.

    2013-01-01

    Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly understood. This has limited the development of effective pharmacotherapy. The current therapeutic armamentaria for ET represent the product of careful clinical observation rather than targeted molecular modeling. Here we review their pharmacokinetics, metabolism, dosing, and adverse effect profiles and propose a treatment algorithm. We also discuss the concept of medically refractory tremor, as therapeutic trials should be limited unless invasive therapy is contraindicated or not desired by patients. PMID:24385718

  13. Pharmacotherapy of essential tremor.

    PubMed

    Hedera, Peter; Cibulčík, František; Davis, Thomas L

    2013-01-01

    Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly understood. This has limited the development of effective pharmacotherapy. The current therapeutic armamentaria for ET represent the product of careful clinical observation rather than targeted molecular modeling. Here we review their pharmacokinetics, metabolism, dosing, and adverse effect profiles and propose a treatment algorithm. We also discuss the concept of medically refractory tremor, as therapeutic trials should be limited unless invasive therapy is contraindicated or not desired by patients. PMID:24385718

  14. Overview of essential tremor.

    PubMed

    Zesiewicz, Theresa A; Chari, Abinaya; Jahan, Israt; Miller, Amber M; Sullivan, Kelly L

    2010-01-01

    Essential tremor (ET) is one of the most common movement disorders in the world. Despite this, only one medication (propranolol) is approved by the Food and Drug Administration (FDA) to treat it. Fortunately, recent studies have identified some additional medications as treatment of ET. Surgical procedures, such as deep brain stimulation of the ventral intermediate nucleus of the thalamus, offer treatment for refractory tremor. The epidemiology, pathogenesis, and medical and surgical treatment of ET will be discussed in this paper. PMID:20856604

  15. Highway Maintenance Equipment Operator. Specialized Equipment. Training Materials.

    ERIC Educational Resources Information Center

    Perky, Sandra Dutreau; And Others

    This curriculum guide provides instructional materials to assist in training equipment operators in the safe and effective use of highway maintenance equipment. It includes 18 units of instruction covering the large equipment used in maintenance operations. Each unit of instruction consists of eight basic components: performance objectives,…

  16. Highway Maintenance Equipment Operator. Miscellaneous Equipment. Training Materials.

    ERIC Educational Resources Information Center

    Perky, Sandra Dutreau; And Others

    This curriculum guide provides instructional materials to assist in training equipment operators in the safe and effective use of highway maintenance equipment. It includes six units of instruction covering the small, specialized equipment used in maintenance operations. Each unit of instruction consists of eight basic components: performance…

  17. Getting Equipped and Staying Equipped, Part 2: Finding the Funds.

    ERIC Educational Resources Information Center

    Jordahl, Gregory; Orwig, Ann

    1995-01-01

    Suggests how school libraries can fund computer equipment; gain assistance from high-tech businesses; develop business partnerships and foundations; lease equipment; accept equipment donations; fund raise; build money into the budget; and communicate school needs with budget voters. Sidebars include leasing advice; resources for parent-teacher

  18. Highway Maintenance Equipment Operator. Specialized Equipment. Training Materials.

    ERIC Educational Resources Information Center

    Perky, Sandra Dutreau; And Others

    This curriculum guide provides instructional materials to assist in training equipment operators in the safe and effective use of highway maintenance equipment. It includes 18 units of instruction covering the large equipment used in maintenance operations. Each unit of instruction consists of eight basic components: performance objectives,

  19. Survey equipment for leakage

    SciTech Connect

    Ross, P.A. )

    1993-02-01

    The analytical methods used by many chemical process industries to estimate fugitive emissions assume a worst-case scenario. These methods ignore the efforts made by operators to reduce emissions. This article discusses the need for a program to develop and implement a fugitive-emissions survey of all equipment components, and to determine actual emissions at a given site. The responsibilities of the project manager and other team members are outlined. Repeating the onsite emissions monitoring program at site-specific intervals will help operators to validate previous findings and evaluate the plant's progress in reducing process emissions

  20. Monitoring equipment for multitasking multimicroprocessors

    SciTech Connect

    Negrini, R.; Pozzi, F.; Scarabottolo, N.

    1983-01-01

    The structure of monitoring equipment capable of evaluating performances of multimicroprocessor systems is described. The goals and field of application of such equipment are discussed, along with characteristics both at the hardware and software levels. 4 references.

  1. Precision Instrument and Equipment Repairers.

    ERIC Educational Resources Information Center

    Wyatt, Ian

    2001-01-01

    Explains the job of precision instrument and equipment repairers, who work on cameras, medical equipment, musical instruments, watches and clocks, and industrial measuring devices. Discusses duties, working conditions, employment and earnings, job outlook, and skills and training. (JOW)

  2. Guidelines for Purchasing Playground Equipment.

    ERIC Educational Resources Information Center

    Neugebauer, Roger

    1998-01-01

    Notes that the purchase of playground equipment is one of the most important decisions center directors make. Offers advice from a number of playground equipment manufacturers that suggests directors consider activities, safety, construction, installation, and warranty when purchasing equipment. Also suggests interviewing other directors about…

  3. Safety Equipment in the Lab.

    ERIC Educational Resources Information Center

    Denham, Willard A.S.

    1964-01-01

    Findings of two recent surveys on safety equipment in laboratory facilities are presented. The first survey was a pilot study of emergency shower and eye wash equipment. This study was followed by a more comprehensive random survey of safety equipment in 2,820 labs. Among other findings, the surveys indicate that many plants are underequipped, or…

  4. Scientist Using Terrestrial Lidar Equipment

    Chris Soulard using the Terrestrial Lidar to scan study area in the Grand Canyon-Parashant National Monument, AZ.  Note the bag of ice on the equipment.  High temperates can cause equipment to overheat, requiring scientists to be creative in protecting equipment....

  5. Gender and Psychological Essentialism

    PubMed Central

    Heyman, Gail D.; Giles, Jessica W.

    2010-01-01

    SUMMARY When individuals reason in an essentialist way about social categories, they assume that group differences reflect inherently different natures (Gelman, 2003; Rothbart & Taylor, 1992). This paper describes the psychological and social implications of essentialist beliefs, and examines the extent to which children exhibit psychological essentialism when reasoning about gender. The authors discuss reasons young children as well as older children show essentialist reasoning in some contexts, but not in others. Finally, the authors suggest directions for future research, and discuss a primary challenge to many working in this field: reduction of rigid gender beliefs. PMID:21528097

  6. The essential moral self.

    PubMed

    Strohminger, Nina; Nichols, Shaun

    2014-04-01

    It has often been suggested that the mind is central to personal identity. But do all parts of the mind contribute equally? Across five experiments, we demonstrate that moral traits-more than any other mental faculty-are considered the most essential part of identity, the self, and the soul. Memory, especially emotional and autobiographical memory, is also fairly important. Lower-level cognition and perception have the most tenuous connection to identity, rivaling that of purely physical traits. These findings suggest that folk notions of personal identity are largely informed by the mental faculties affecting social relationships, with a particularly keen focus on moral traits. PMID:24503450

  7. Theorizing gender in the face of social change: is there anything essential about essentialism?

    PubMed

    Morton, Thomas A; Postmes, Tom; Haslam, S Alexander; Hornsey, Matthew J

    2009-03-01

    The authors examine how beliefs about the stability of the social hierarchy moderate the link between sexism and essentialist beliefs about gender and how the expression of essentialist beliefs might reciprocally affect the social structure. Studies 1 (N = 240) and 2 (N = 143) presented gender-based inequality as stable, changing, or changed. In both studies, sexism was positively associated with essentialism only among men and only when inequality was presented as changing. Study 3 (N = 552) explored the possible consequences of expressing essentialist theories for social change. Exposure to essentialist theories increased both men's and women's acceptance of inequality. Exposure further increased men's support for discriminatory practices and boosted their self-esteem. These patterns demonstrate that although essentialism is linked to prejudice, this link is itself not essential. Rather, essentialism may be invoked strategically to protect higher status when this is threatened by change and may be successful in so doing. PMID:19254110

  8. Core stability exercise principles.

    PubMed

    Akuthota, Venu; Ferreiro, Andrea; Moore, Tamara; Fredericson, Michael

    2008-02-01

    Core stability is essential for proper load balance within the spine, pelvis, and kinetic chain. The so-called core is the group of trunk muscles that surround the spine and abdominal viscera. Abdominal, gluteal, hip girdle, paraspinal, and other muscles work in concert to provide spinal stability. Core stability and its motor control have been shown to be imperative for initiation of functional limb movements, as needed in athletics. Sports medicine practitioners use core strengthening techniques to improve performance and prevent injury. Core strengthening, often called lumbar stabilization, also has been used as a therapeutic exercise treatment regimen for low back pain conditions. This article summarizes the anatomy of the core, the progression of core strengthening, the available evidence for its theoretical construct, and its efficacy in musculoskeletal conditions. PMID:18296944

  9. Lunar mining equipment

    NASA Technical Reports Server (NTRS)

    Bekkedahl, S.; Breidenbach, T.; Brown, M.; Francis, C.; Freeman, J.; Scharnott, M.; Thon, R.

    1989-01-01

    This document contains preliminary concepts for mining and beneficiation of lunar regolith from a 50 metric ton/day mine. Assumptions for the design are outlined below. Lunar regolith is the material to be mined. Since it is already a fine-grained material, the two steps of crushing and breakup from a rock surface are eliminated. The size of the operation was set at 50 metric tons of regolith/day for a three-year period. Operations will occur around the clock to make most efficient use of equipment, thus we assume 24 hr/day. For simplicity we have assumed that the lunar regolith has a uniform density of 1.68 and that it can be mined to a depth of 6 m. No research was done on power supply or distribution. It was left to others to consider the various trade-offs between nuclear and solar power and to design the needed utility system.

  10. Orbital construction support equipment

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Approximately 200 separate construction steps were defined for the three solar power satellite (SPS) concepts. Detailed construction scenarios were developed which describe the specific tasks to be accomplished, and identify general equipment requirements. The scenarios were used to perform a functional analysis, which resulted in the definition of 100 distinct SPS elements. These elements are the components, parts, subsystems, or assemblies upon which construction activities take place. The major SPS elements for each configuration are shown. For those elements, 300 functional requirements were identified in seven generic processes. Cumulatively, these processes encompass all functions required during SPS construction/assembly. Individually each process is defined such that it includes a specific type of activity. Each SPS element may involve activities relating to any or all of the generic processes. The processes are listed, and examples of the requirements defined for a typical element are given.

  11. Planning equipment acquisitions.

    PubMed

    Sadock, J M

    1995-08-01

    As the mire of healthcare reform continues to grow, many providers are developing an insatiable appetite for alternatives to the way they currently do business. For some, solutions come in the form of repackaging the same old stuff. Others have jumped recklessly into every managed, capitated, or reformed idea that has come along. Old-school thinkers are still awaiting government direction. Providers of quality healthcare face increasing demands on their shrinking capital funds. An aging population, indigent care, AIDS patients, medical waste disposal, nursing shortages, declining reimbursement, increasing labor costs, and the federal healthcare reform threat have negatively affected cash flow. Though previous cost-plus reimbursement encouraged wasteful spending, the threat of healthcare reform has already caused providers and suppliers alike to work together to cut costs even without government mandates. The impact has been the closure of over 600 facilities nationwide in the past ten years. More than 70,000 acute care hospital beds have been lost from the US healthcare system. Many healthcare facilities have merged into managed care systems, integrated delivery networks, and regional alliances whose costs can be consolidated and controlled. At the same time, new services and profit centers are also being created to increase revenue. A healthcare moves into alternative care environments--home care, ambulatory care, diagnostic testing--these providers need more capital equipment to serve an increased patient load. Coupled with an aging installed base of technology in the acute care environment, healthcare managers face an ever-growing need for capital equipment and creative financing programs to meet longer payment options.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:10144860

  12. Seismic qualification of unanchored equipment

    SciTech Connect

    Moran, T.J.

    1995-12-01

    This paper describes procedures used to design and qualify unanchored equipment to survive Seismic events to the PC = 4 level in a moderate seismic area. The need for flexibility to move experimental equipment together with the requirements for remote handling in a highly-radioactive non-reactor nuclear facility precluded normal equipment anchorage. Instead equipment was designed to remain stable under anticipated DBE floor motions with sufficient margin to achieve the performance goal. The equipment was also designed to accommodate anticipated sliding motions with sufficient. The simplified design criteria used to achieve these goals were based on extensive time-history simulations of sliding, rocking, and overturning of generic equipment models. The entire process was subject to independent peer review and accepted in a Safety Evaluation Report. The process provides a model suitable for adaptation to similar applications and for assessment of the potential for seismic damage of existing, unanchored equipment In particular, the paper describes: (1) Two dimensional sliding studies of deformable equipment subject to 3-D floor excitation as the basis for simplified sliding radius and sliding velocity design criteria. (2) Two dimensional rocking and overturning simulations of rigid equipment used to establish design criteria for minimum base dimensions and equipment rigidity to prevent overturning. (3) Assumed mode rocking analyses of deformable equipment models used to establish uplift magnitudes and subsequent impacts during stable rocking motions. The model used for these dynamic impact studies is reported elsewhere.

  13. TQM: the essential concepts.

    PubMed

    Chambers, D W

    1998-01-01

    This is an introduction to the major concepts in total quality management, a loose collection of management approaches that focus on continuous improvement of processes, guided by routine data collection and adjustment of the processes. Customer focus and involvement of all members of an organization are also characteristics commonly found in TQM. The seventy-five-year history of the movement is sketched from its beginning in statistical work on quality assurance through the many improvements and redefinitions added by American and Japanese thinkers. Essential concepts covered include: control cycles, focus on the process rather than the defects, the GEAR model, importance of the customer, upstream quality, just-in-time, kaizen, and service quality. PMID:9697367

  14. Essential Variational Poisson Cohomology

    NASA Astrophysics Data System (ADS)

    De Sole, Alberto; Kac, Victor G.

    2012-08-01

    In our recent paper "The variational Poisson cohomology" (2011) we computed the dimension of the variational Poisson cohomology {{{H}^bullet_K({V})}} for any quasiconstant coefficient ℓ × ℓ matrix differential operator K of order N with invertible leading coefficient, provided that {{{V}}} is a normal algebra of differential functions over a linearly closed differential field. In the present paper we show that, for K skewadjoint, the {{{Z}}} -graded Lie superalgebra {{{H}^bullet_K({V})}} is isomorphic to the finite dimensional Lie superalgebra {{widetilde{H}(Nell,S)}} . We also prove that the subalgebra of "essential" variational Poisson cohomology, consisting of classes vanishing on the Casimirs of K, is zero. This vanishing result has applications to the theory of bi-Hamiltonian structures and their deformations. At the end of the paper we consider also the translation invariant case.

  15. Essential biodiversity variables

    USGS Publications Warehouse

    Pereira, H.M.; Ferrier, S.; Walters, M.; Geller, G.N.; Jongman, R.H.G.; Scholes, R.J.; Bruford, M.W.; Brummitt, N.; Butchart, S.H.M.; Cardoso, A.C.; Coops, N.C.; Dulloo, E.; Faith, D.P.; Freyhof, J.; Gregory, R.D.; Heip, C.; Höft, R.; Hurtt, G.; Jetz, W.; Karp, D.S.; McGeoch, M.A.; Obura, D.; Onada, Y.; Pettorelli, N.; Reyers, B.; Sayre, R.; Scharlemann, J.P.W.; Stuart, S.N.; Turak, E.; Walpole, M.; Wegmann, M.

    2013-01-01

    Reducing the rate of biodiversity loss and averting dangerous biodiversity change are international goals, reasserted by the Aichi Targets for 2020 by Parties to the United Nations (UN) Convention on Biological Diversity (CBD) after failure to meet the 2010 target (1, 2). However, there is no global, harmonized observation system for delivering regular, timely data on biodiversity change (3). With the first plenary meeting of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) soon under way, partners from the Group on Earth Observations Biodiversity Observation Network (GEO BON) (4) are developing—and seeking consensus around—Essential Biodiversity Variables (EBVs) that could form the basis of monitoring programs worldwide.

  16. John Adams' essential tremor.

    PubMed

    Louis, Elan D; Kavanagh, Patricia

    2005-12-01

    John Adams (1735-1826), one of the signers of the Declaration of Independence, was the second President of the United States. Adams had tremor for many years, about which little has been written. We examined John Adams' penmanship over a 62-year period and studied his correspondence and diaries. It is not clear when Adams' tremor began, although in a diary entry dated 6 December 1760, when Adams was 25 years old, there is evidence of low-amplitude kinetic tremor. The tremor continued in his written correspondence, becoming more persistent over time. Later in life, the clarity of his written correspondence diminished, with greater decomposition of characters and a reduction in the size of individual characters. This finding raises some speculation as to whether Adams could have been developing some parkinsonism, although the evidence in favor of this is not compelling. The most likely diagnosis was essential tremor. PMID:16078215

  17. Teletherapy equipment and simulators

    SciTech Connect

    de Almeida, C.E.; Cecatti, E.R.

    1984-06-01

    A comprehensive Quality Assurance program in a radiation therapy center is desirable regardless of its size, and should cover among others the following areas: physical parameters of the therapy machines, dosimetric standards, preventive maintenance of radiation emitting sources and measuring instruments. In a radiation therapy center, regardless of its size and patient load, it is advisable to have a quality assurance program covering all the treatment planning steps. The following areas should be taken into consideration: physical parameters of the machines; dosimetric standards; radiation safety procedures and preventive maintenance of irradiators and radiation measuring instruments. The minimum instrumentation required and the critical parameters to be observed to establish a quality assurance program are discussed; the suggestions are applicable to the various sizes of radiation therapy centers. It is essential that all the procedures and results obtained are well documented and a critical evaluation of the program be performed periodically.

  18. 14 CFR 29.1353 - Electrical equipment and installations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Electrical Systems and... must be installed so that operation of any one unit or system of units will not adversely affect the simultaneous operation of any other electrical unit or system essential to safe operation. (b) Cables must...

  19. 14 CFR 25.1353 - Electrical equipment and installations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Electrical Systems and... installed so that operation of any one unit or system of units will not adversely affect the simultaneous operation of any other electrical unit or system essential to safe operation. Any electrical...

  20. Equipping surgeons as educators.

    PubMed

    Fry, Heather

    2009-03-01

    There is a developing interest in equipping surgeons as educators but a perceived lack of knowledge and evidence about how to do this effectively, or how to reward and recognize educational expertise within the surgical career structure. A brief consideration of the surgical educator role is offered. The findings and conclusions of a meta-analysis of the influence of faculty development in medical education are summarized. Various sources are drawn on to present an overview of master's level provision in medical education and a master's in surgical education is outlined. Issues relating to developing suitable curricula, educational accreditation, recognition, reward and career structure are raised and some UK approaches to these areas summarized. Evidence indicates the importance of context in training medical educators, the value of experiential learning, training that is spread over time and training that mixes theory, practice and reflection. A schema for recognizing educational expertise, created as an outcome of analysis of the evidence and current provision, is presented. The effect of a possible change from educational training being voluntary to the introduction of a compulsory regime is raised as an area requiring further discussion and evidence collection. Mechanisms by which to acknowledge, reward and recognize education expertise in surgeons do not generally exist; it is suggested their development would be timely. PMID:19317787

  1. 21 CFR 606.60 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Equipment § 606.60 Equipment. (a) Equipment... necessary. Laboratory thermometers Before initial use. Electronic thermometers Monthly. Vacuum...

  2. 21 CFR 606.60 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Equipment § 606.60 Equipment. (a) Equipment... necessary. Laboratory thermometers Before initial use. Electronic thermometers Monthly. Vacuum...

  3. 21 CFR 606.60 - Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Equipment § 606.60 Equipment. (a) Equipment... necessary. Laboratory thermometers Before initial use. Electronic thermometers Monthly. Vacuum...

  4. 21 CFR 606.60 - Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Equipment § 606.60 Equipment. (a) Equipment... necessary. Laboratory thermometers Before initial use. Electronic thermometers Monthly. Vacuum...

  5. 21 CFR 606.60 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Equipment § 606.60 Equipment. (a) Equipment... necessary. Laboratory thermometers Before initial use. Electronic thermometers Monthly. Vacuum...

  6. Assimilation is Essential

    NASA Astrophysics Data System (ADS)

    Kelemen, P. B.

    2002-12-01

    Norman Bowen's 1922 paper, `The behavior of inclusions in igneous magmas', and its abridged version in The Evolution of the Igneous Rocks, are the classic papers on reaction between silicate melt and minerals. Bowen showed that dissolution of minerals in magma above its liquidus temperature is limited to a few percent of the melt mass, because the heat of fusion of silicates is much larger than the heat capacity of silicate melt. Thus, he proposed that for extensive reaction between melt and rock, there must be a link between dissolution of one phase and crystallization of another. Bowen's reasoning should be the starting point for all studies of igneous open systems. Nonetheless, Bowen reached some controversial conclusions. He wrote, `It is doubtful whether the presence of foreign matter is ever essential to the production of any particular type of differentiate'. This was during debate over the `calc-alkaline trend', with high Mg/(Mg+Fe), or Mg#, over a range of silica contents. Bowen reasoned that the calc-alkaline trend started with basalt, a primary melt, and ended with granite, the end-product of fractional crystallization, so the entire trend must be due to fractional crystallization. However, Clarence Fenner thought that fractional crystallization of basalt produced decreasing Mg# at nearly constant silica, a `tholeiitic trend'. For Fenner, the debate wasn't aboutgranite, but about intermediate, calc-alkaline andesites, (i.e., high Mg# andesite, 54 wt% < SiO2 < 63 wt%, Mg# > 0.45). This debate is still not resolved, but there are cases in which reaction of basaltic melt with granitic rock was essential in producing high Mg# andesites. Similarly, some high Mg# andesites arise via magma mixing, a kind of `incorporation of foreign matter'. Some high Mg# andesites are partial melts of peridotite, and some arise via melt-rock reaction in the mantle. The `andesite problem' has extra importance because continental crust has a high Mg# andesite composition. Bowen quantified the energy required to heat wall rock to magmatic temperature, and showed how it limited the extent of reaction. This reflected an implicit emphasis on crustal processes. Also, Bowen was probably unaware of reactions between melt and mantle peridotite, resulting from (1) changing peridotite/melt equilibria with pressure, (2) gradual cooling of rising melt in the mantle `lithosphere', and (3) partial melting of subducted basalt and/or sediment. Because reactions between melt and mantle do not require heating cold rock, they can be very extensive. Some common reactions produce more liquid at mantle conditions, even in systems closed to heat transfer. Melt-rock reactions in the mantle can have a dramatic effect on resulting liquid. Trace element exchange during porous flow can enrich liquid in incompatible elements to the theoretical limit of an infinitessimally small degree melt via `zone refining' (Harris GCA 1959). Decreasing melt mass during trace element exchange produces additional enrichment. Increasing volatile content can even produce separation of immiscible carbonatite and silicate melts. Because zone refining maintains equilibrium between liquid and peridotite, it can produce a variety of different `primary melts' from the same parental liquid. Melt-mantle reactions also form solid products, such as discordant mantle dunites. Dunites with replacive contact relationships form via reaction between ascending melt and peridotite because the olivine primary phase volume expands with decreasing pressure. Open-system processes are essential to formation of these rocks. In turn, dunites transport olivine-saturated basalt through orthopyroxene-bearing, shallow mantle peridotite, and thus play a key role in determining the composition of oceanic crust.

  7. Fertility in Essential Tremor

    PubMed Central

    Louis, Elan D.

    2008-01-01

    Background The view of essential tremor (ET) as a degenerative disorder, which is now gaining support from postmortem studies, is at odds with traditional views of ET as a ‘super-healthy’ condition characterized by increased longevity and fertility. Longevity has recently been re-examined in ET, yet fertility, measured by number of offspring, has never been critically assessed in this disease. The objective was to determine whether ET cases and controls differ in terms of number of children. Methods Family history data were collected on ET cases and controls from 2 distinct sources, a population and a clinical (referred) sample. Results In the population, the number of children was similar in 59 cases vs. 72 controls [mean ± SD (median) = 2.3 ± 2.9 (1) vs. 2.2 ± 1.8 (2); p = 0.26]. In the referred sample, number of children was similar in 184 cases vs. 241 controls [2.0 ± 1.5 (2) vs. 1.9 ± 1.7 (2); p = 0.33]. In adjusted analyses, results were similar. Conclusions Fertility, measured by number of children, was similar in cases and controls. With a newer understanding of the biological substrate of ET emerging from postmortem studies, it is important to critically reassess this and other fundamental biological questions about the disease. Copyright © 2008 S. Karger AG, Basel PMID:18784418

  8. Imaging essential tremor.

    PubMed

    Isaias, Ioannis U; Marotta, Giorgio; Hirano, Shigeki; Canesi, Margherita; Benti, Riccardo; Righini, Andrea; Tang, Chengke; Cilia, Roberto; Pezzoli, Gianni; Eidelberg, David; Antonini, Angelo

    2010-04-30

    To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [(99m)Tc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akinetic-rigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET. PMID:20437537

  9. Genetics Home Reference: essential tremor

    MedlinePlus

    ... health and development? More about Mutations and Health Inheritance Pattern Essential tremor can be passed through generations in families, but the inheritance pattern varies. In most affected families, essential tremor appears ...

  10. Information technology equipment cooling system

    DOEpatents

    Schultz, Mark D.

    2014-06-10

    According to one embodiment, a system for removing heat from a rack of information technology equipment may include a sidecar indoor air to liquid heat exchanger that cools warm air generated by the rack of information technology equipment. The system may also include a liquid to liquid heat exchanger and an outdoor heat exchanger. The system may further include configurable pathways to connect and control fluid flow through the sidecar heat exchanger, the liquid to liquid heat exchanger, the rack of information technology equipment, and the outdoor heat exchanger based upon ambient temperature and/or ambient humidity to remove heat from the rack of information technology equipment.

  11. Orbiter electrical equipment utilization baseline

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The baseline for utilization of Orbiter electrical equipment in both electrical and Environmental Control and Life Support System (ECLSS) thermal analyses is established. It is a composite catalog of Space Shuttle equipment, as defined in the Shuttle Operational Data Book. The major functions and expected usage of each component type are described. Functional descriptions are designed to provide a fundamental understanding of the Orbiter electrical equipment, to insure correlation of equipment usage within nominal analyses, and to aid analysts in the formulation of off-nominal, contingency analyses.

  12. VIEW OF MICROMACHINING, HIGH PRECISION EQUIPMENT USED TO CUSTOM MAKE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF MICRO-MACHINING, HIGH PRECISION EQUIPMENT USED TO CUSTOM MAKE SMALL PARTS. LUMPS OF CLAY; SHOWN IN THE PHOTOGRAPH, WERE USED TO STABILIZE PARTS BEING MACHINED. (11/1/87) - Rocky Flats Plant, Stainless Steel & Non-Nuclear Components Manufacturing, Southeast corner of intersection of Cottonwood & Third Avenues, Golden, Jefferson County, CO

  13. VIEW OF ULTRASONIC TESTING EQUIPMENT IN BUILDING 991. THIS EQUIPMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF ULTRA-SONIC TESTING EQUIPMENT IN BUILDING 991. THIS EQUIPMENT NON-DESTRUCTIVELY TESTS WEAPONS COMPONENTS FOR FLAWS AND CRACKS. (9/11/85) - Rocky Flats Plant, Final Assembly & Shipping, Eastern portion of plant site, south of Spruce Avenue, east of Tenth Street & north of Central Avenue, Golden, Jefferson County, CO

  14. Power Product Equipment Technician: Equipment Systems. Teacher Edition. Student Edition.

    ERIC Educational Resources Information Center

    Hilley, Robert

    This packet contains teacher and student editions on the topic of equipment systems, intended for the preparation of power product equipment technicians. This publication contains seven units: (1) principles of power transmission; (2) mechanical drive systems; (3) principles of fluid power; (4) hydraulic and pneumatic drive systems; (5) wheel and…

  15. 141. ARAIII Equipment location plan. Includes list of equipment and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    141. ARA-III Equipment location plan. Includes list of equipment and location in reactor, control, and other buildings. Aerojet-general 880-area/GCRE-101-U-1. Date: February 1958. Ineel index code no. 063-0101-65-013-192508. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

  16. Power Product Equipment Technician: Equipment Systems. Teacher Edition. Student Edition.

    ERIC Educational Resources Information Center

    Hilley, Robert

    This packet contains teacher and student editions on the topic of equipment systems, intended for the preparation of power product equipment technicians. This publication contains seven units: (1) principles of power transmission; (2) mechanical drive systems; (3) principles of fluid power; (4) hydraulic and pneumatic drive systems; (5) wheel and

  17. Laptop image transmission equipment

    NASA Astrophysics Data System (ADS)

    Mocenter, Michael M.

    1991-12-01

    Imagery and other visual information have become a critical element in planning and performing modern military operations. The effectiveness of this imagery information is often directly tied to the time it takes to get from the collector of this imagery to the user of the imagery. Hard copy distribution of annotated imagery to the tactical commander is hampered by the lack of effective communications paths, and the tactical use of hand held imagery is restricted by the lack of film processing facilities. The military has begun to rely on electronic imagery and digital communications technology for answers, with some success. The new obstacles created by applied electronic imagery are interoperability standards and effective use of communications bandwidth in a tactical environment. New technological developments in computer hardware/software have changed this situation by allowing for the gathering, dissemination, and transfer of near-real-time information to various intelligence audiences at any location. The Naval Air Development Center (NAVAIRDEVCEN) has coupled commercial-off-the-shelf (COTS) technology with National Image Transmission Formats (NITF) Standards to develop a Secondary Imagery Dissemination System (SIDS) package that is designed to meet the flexibility challenge of the tactical military environment. This tailorable SIDS package is called Laptop Image Transmission Equipment (LITE). The LITE system is an extension of the Navy's existing Fleet Imagery Support Terminal (FIST) into the man-portable tactical environment. As such, LITE development is focused on developing flexible imagery input (from sources such as filmless cameras) and connectivity to tactical communications paths and ruggedization/miniaturization issues. The LITE system, in prototype form, has already found application through operational use in special operations, counter narcotics operations, and classic air/ground/sea military operations. This paper provides an overview of the LITE components, specifications, operations, and future developments for the system.

  18. Slope stability and stabilization methods

    SciTech Connect

    Abramson, L.W.; Lee, T.S.; Boyce, G.M.; Sharma, S.S.

    1995-12-01

    Slope stability can be a major problem during the construction of surface facilities. Cutting into existing ground disturbs the mechanics of the surrounding area, which can result in landslides and rock falls. This practical reference gives you the comprehensive information you need for slope stability analysis, suitable methods of analysis with and without the use of computers, and examples of common stability problems and stabilization methods for cuts and fills. It includes detailed discussions of methods used in slope stability analysis, including the Ordinary Method of Slices, Simplified Janbu Method, Simplified Bishop Method, Spencer`s Method, other limit equilibrium methods, numerical methods, total stress analysis, effective stress analysis, and the use of computer programs to solve problems. Chapters include: General Slope Stability Concepts; Engineering Geology Principles; Groundwater Conditions; Geologic Site Exploration; Laboratory Testing Interpretation; Slope Stability Concepts; Slope Stabilization Methods; and Design, Construction and Maintenance.

  19. Comprehensive framework for preventive maintenance priority of medical equipment.

    PubMed

    Saleh, Neven; Balestra, Gabriella

    2015-08-01

    Throughout the medical equipment life cycle, preventive maintenance is considered one of the most important stages that should be managed properly. However, the need for better management and control by giving a reasonable prioritization for preventive maintenance becomes essential. The purpose of this study is to develop a comprehensive framework for preventive maintenance priority of medical equipment using Quality Function Deployment (QFD) and Fuzzy Logic (FL). The quality function deployment is proposed in order to identify the most important criteria that could impact preventive maintenance priority decision; meanwhile the role of the fuzzy logic is to generate a priority index of the list of equipment considering those criteria. The model validation was carried out on 140 pieces of medical equipment belonging to two hospitals. In application, we propose to classify the priority index into five classes. The results indicate that the strong correlation existence between risk-based criteria and preventive maintenance priority decision. PMID:26736488

  20. Heavy Equipment Mechanic. Instructor Edition.

    ERIC Educational Resources Information Center

    Hendrix, Laborn J.; And Others

    This manual is intended to assist heavy equipment instructors in teaching the latest concepts and functions of heavy equipment. It includes 7 sections and 27 instructional units. Sections (and units) are: orientation (shop safety and first aid, hand tools and miscellaneous tools, measuring, basic rigging and hoisting), engines (basic engine

  1. Food Service Equipment and Appurtenances.

    ERIC Educational Resources Information Center

    National Sanitation Foundation, Ann Arbor, MI.

    Equipment design specifications are presented relating to tables of all kinds, counters, sinks and drainboards, bins, shelves, drawers, hoods and similar kitchen appurtenances, not including baking, roasting, toasting, broiling or frying equipment, food preparation machinery such as slicers, choppers, and cutters, mixers and grinders, steam…

  2. Heavy Equipment Mechanic Program Guide.

    ERIC Educational Resources Information Center

    Georgia Univ., Athens. Dept. of Vocational Education.

    Designed to train an entry-level mechanic, this heavy equipment mechanic program guide presents the standard curriculum for technical institutes in Georgia. The curriculum addresses the minimum competencies for a heavy equipment mechanic program. The general information section contains the following: purpose and objectives; program description,…

  3. Tips for Buying Exercise Equipment

    MedlinePlus

    ... esta página en español Tips for Buying Exercise Equipment Related Items Weight Loss Challenge Free Trials Can ... photo? What to Do Before You Buy Exercise Equipment You’ve done your job and looked at ...

  4. Available Equipment in School Foodservice.

    ERIC Educational Resources Information Center

    Meyer, Mary Kay

    This report provides data on the National Food Service Management Institute's multi-year research project that identified type, style, age, and condition of available food service equipment in K-12 schools nationwide. The study found that smaller schools, serving less than 400 lunches per day, had kitchens equipped with ranges, small…

  5. Food Service Equipment. Third Edition.

    ERIC Educational Resources Information Center

    Jernigan, Anna Katherine; Ross, Lynne Nannen

    This book provides information that will help in purchasing the kind of food service equipment most useful in any given facility. Hence, it should be of value to architects, contractors, administrators, dietitians, managers, and others involved in remodeling a facility, replacing equipment, and/or improving the efficiency of food service…

  6. Heavy Equipment Mechanic. Instructor Edition.

    ERIC Educational Resources Information Center

    Hendrix, Laborn J.; And Others

    This manual is intended to assist heavy equipment instructors in teaching the latest concepts and functions of heavy equipment. It includes 7 sections and 27 instructional units. Sections (and units) are: orientation (shop safety and first aid, hand tools and miscellaneous tools, measuring, basic rigging and hoisting), engines (basic engine…

  7. Laser Frequency Stabilization

    NASA Technical Reports Server (NTRS)

    Donelan, Darsa; Mueller, Guido; Thorpe, James; Livas, Jeffrey

    2011-01-01

    Laser ranging and interferometry are essential technologies allowing for many astounding new spacebased missions such as the Laser Interferometer Space Antenna (LISA) to measure gravitational radiation emitted from distant super massive black hole mergers or distributed aperture telescopes with unprecedented angular resolution in the NIR or visible regime. The requirements on laser frequency noise depend on the residual motion and the distances between the spacecraft forming the interferometer. The intrinsic frequency stability of commercial lasers is several orders of magnitude above these requirements. Therefore, it is necessary for lasers to be stabilized to an ultrastable frequency reference so that they can be used to sense and control distances between spacecraft. Various optical frequency references and frequency stabilization schemes are considered and investigated for the applicability and usefulness for space-based interferometry missions.

  8. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  9. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  10. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  11. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  12. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  13. Information technology equipment cooling method

    DOEpatents

    Schultz, Mark D.

    2015-10-20

    According to one embodiment, a system for removing heat from a rack of information technology equipment may include a sidecar indoor air to liquid heat exchanger that cools air utilized by the rack of information technology equipment to cool the rack of information technology equipment. The system may also include a liquid to liquid heat exchanger and an outdoor heat exchanger. The system may further include configurable pathways to connect and control fluid flow through the sidecar heat exchanger, the liquid to liquid heat exchanger, the rack of information technology equipment, and the outdoor heat exchanger based upon ambient temperature and/or ambient humidity to remove heat generated by the rack of information technology equipment.

  14. Aeration equipment for small depths

    NASA Astrophysics Data System (ADS)

    Sluše, Jan; Pochylý, František

    2015-05-01

    Deficit of air in water causes complications with cyanobacteria mainly in the summer months. Cyanobacteria is a bacteria that produces poison called cyanotoxin. When the concentration of cyanobacteria increases, the phenomena "algal bloom" appears, which is very toxic and may kill all the organisms. This article describes new equipment for aeration of water in dams, ponds and reservoirs with small depth. This equipment is mobile and it is able to work without any human factor because its control is provided by a GPS module. The main part of this equipment consists of a floating pump which pumps water from the surface. Another important part of this equipment is an aerator where water and air are blended. Final aeration process runs in the nozzles which provide movement of all this equipment and aeration of the water. Simulations of the flow are solved by multiphase flow with diffusion in open source program called OpenFOAM. Results will be verified by an experiment.

  15. An overview of non-road equipment emissions in China

    NASA Astrophysics Data System (ADS)

    Wang, Fan; Li, Zhen; Zhang, Kaishan; Di, Baofeng; Hu, Baomei

    2016-05-01

    As the vehicle population has dramatically increased in China in the past two decades, vehicle emissions have become one of the major sources to air pollution across the entire country, especially for the metropolitan cities such as Beijing and Shanghai. Most of the non-road equipment are diesel-fueled and have been proved to be a key source for NOx and PM emissions, contributing significantly to the formation of haze/smog. Therefore, an accurate estimation of emission inventory from non-road equipment is essential for air quality improvement policy making, which mainly depends on the data availability of equipment population, activity, and emissions factor. Compared to on-road vehicles, less studies regarding emissions characterization have been conducted and investigated for non-road mobile sources in China. Thus, in order to identify the data gaps and future research needs, the objective of this study is to review the current status of research in non-road mobile emissions. Five types of non-road equipment were addressed in this study, including agricultural equipment, industrial equipment, river/ocean-going vessels, locomotives, and commercial airplanes, with a focus on the former two. The equipment are further classified mainly based on national standards and data availability to account for fuel type, job duties and others. This investigation has found that the research regarding emissions from non-road equipment is still at its early stage and there is a huge data gap for both activity and emissions factors. For most of the study, data used for emission inventory estimation were based on either literature with similar equipment or as-developed emissions models such as NONROAD or CORPERT. The representativeness of these data to the localities was not much discussed in those studies, which might have weakened the accuracy of the estimated emission inventory. For future study, real-world in-use measurements of activities and emissions for the non-road equipment are desperately needed.

  16. ISAARE: Information System for Adaptive, Assistive, and Recreational Equipment: Volume I: Existence; Volume II, Communication; Volume V, Adaptation.

    ERIC Educational Resources Information Center

    Melichar, Joseph F.

    Described as part of the Information System for Adaptive, Assistive and Recreational Equipment are equipment items for physically handicapped pupils in the functional areas of existence, equipment and adaptation. Reviewed in the existence section are such items as assistive food containers and container stabilizers, feeder accessories, bowel and…

  17. Multi-district equipment management.

    PubMed

    Stamp, J M

    1984-01-01

    Equipment management covers a wide range of topics including evaluation, purchase, maintenance, accident investigation, condemning of equipment and the implementation of safety bulletins and hazard notices. Equipment management can only be as good as the records maintained; a good paper-filing system can be better than a computerized inventory system. This is particularly so in small hospitals where the bulk of such records does not present a problem. The DHSS evaluation programme has helped to answer many questions regarding which type of equipment to purchase. Sheffield has for the last 12 years been fortunate in having its own evaluation service. This service is available to all who require advice regarding new items of equipment. An equipment test report is produced after the evaluation (including manufacturer's comments). A list of evaluations is published annually in order to make other interested parties aware of their availability. The electromedical maintenance section (which now incorporates equipment evaluation) was established about 12 years ago. At that time the staff consisted of three technicians and one part-time secretary. There are now 10 technicians equally divided between two hospital bases, the secretary alternates between the two bases. A principal physicist now acts as the section head. PMID:6442737

  18. Discovery of essential fatty acids

    PubMed Central

    Spector, Arthur A.; Kim, Hee-Yong

    2015-01-01

    Dietary fat was recognized as a good source of energy and fat-soluble vitamins by the first part of the 20th century, but fatty acids were not considered to be essential nutrients because they could be synthesized from dietary carbohydrate. This well-established view was challenged in 1929 by George and Mildred Burr who reported that dietary fatty acid was required to prevent a deficiency disease that occurred in rats fed a fat-free diet. They concluded that fatty acids were essential nutrients and showed that linoleic acid prevented the disease and is an essential fatty acid. The Burrs surmised that other unsaturated fatty acids were essential and subsequently demonstrated that linolenic acid, the omega-3 fatty acid analog of linoleic acid, is also an essential fatty acid. The discovery of essential fatty acids was a paradigm-changing finding, and it is now considered to be one of the landmark discoveries in lipid research. PMID:25339684

  19. Essential Medicines: An Indian Perspective

    PubMed Central

    Maiti, Rituparna; Bhatia, Vikas; Padhy, Biswa Mohan; Hota, Debasish

    2015-01-01

    The concept of defining essential medicines and establishing a list of them was aimed to improve the availability of affordable medicines for the world's poor. Access to essential medicines is a major determinant of health outcomes. Several countries have made substantial progress towards increasing access to essential medicines, but access to essential medicines in developing countries like India is not adequate. In this review we have tried to present the Indian scenario in respect to availability and accessibility of essential medicines over last one decade. To enhance the credibility of Indian healthcare system, procurement and delivery systems of essential medicines have to be strengthened through government commitment, careful selection, adequate public sector financing, efficient distribution systems, control on taxes and duties, and inculcating a culture of rational use of medicines in current and future prescribers. PMID:26435594

  20. Essential Medicines: An Indian Perspective.

    PubMed

    Maiti, Rituparna; Bhatia, Vikas; Padhy, Biswa Mohan; Hota, Debasish

    2015-01-01

    The concept of defining essential medicines and establishing a list of them was aimed to improve the availability of affordable medicines for the world's poor. Access to essential medicines is a major determinant of health outcomes. Several countries have made substantial progress towards increasing access to essential medicines, but access to essential medicines in developing countries like India is not adequate. In this review we have tried to present the Indian scenario in respect to availability and accessibility of essential medicines over last one decade. To enhance the credibility of Indian healthcare system, procurement and delivery systems of essential medicines have to be strengthened through government commitment, careful selection, adequate public sector financing, efficient distribution systems, control on taxes and duties, and inculcating a culture of rational use of medicines in current and future prescribers. PMID:26435594

  1. TRANSPORT AND EMPLACEMENT EQUIPMENT DESCRIPTIONS

    SciTech Connect

    NA

    1997-09-29

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) Transport and Emplacement in the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. The Transport and Emplacement equipment described in this document consists of the following: (1) WP Transporter; (2) Reusable Rail Car; (3) Emplacement Gantry; (4) Gantry Carrier; and (5) Transport Locomotive.

  2. 14 CFR 121.341 - Equipment for operations in icing conditions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... equipped with means for the prevention or removal of ice on windshields, wings, empennage, propellers, and... otherwise determining the formation of ice on the parts of the wings that are critical from the standpoint... functioning deicing anti-icing equipment protecting each propeller, windshield, wing, stabilizing or...

  3. Membrane stabilizer

    DOEpatents

    Mingenbach, William A.

    1988-01-01

    A device is provided for stabilizing a flexible membrane secured within a frame, wherein a plurality of elongated arms are disposed radially from a central hub which penetrates the membrane, said arms imposing alternately against opposite sides of the membrane, thus warping and tensioning the membrane into a condition of improved stability. The membrane may be an opaque or translucent sheet or other material.

  4. Does Shoulder Stabilizations Stabilize Shoulders?

    ClinicalTrials.gov

    2016-03-26

    Glenohumeral Stabilization; Computer Tomography; Subtle or Minor Instability; Unstable Painful Shoulder; Apprehension; Dislocation; Subluxation; Kinematics Modeling; Biomechanics; Motion Capture; 3D Simulation

  5. Designing equipment for hostile environments

    SciTech Connect

    Bayh, R.I. II; Rice, P.W.; Ray, T.W. )

    1992-10-01

    In this paper, two case histories detail how a specially constructed deep well simulator was able to isolate deficiencies with elastomeric and metallic components of wellbore completion equipment. Correcting these problems before tools are installed greatly minimizes the chances of malfunction and the potential for environmental damage. Reliability of downhole completion equipment is greatly influenced by ambient conditions where the equipment must function. These conditions or environment nominally consist of mixtures of solids, liquids and gases under pressure, either produced by the well or injected into it. This is sometimes called the service the equipment sees. The term sour service denotes well environments containing the compound hydrogen sulfide, H[sub 2]S as opposed to those that contain none, which are called sweet or standard-service environments.

  6. Improving equipment reliability through thermography

    SciTech Connect

    Bates, D.E. )

    1990-06-01

    Failure of electrical or mechanical equipment is costly to repair and also results in loss of revenue. Industries spend millions on protective devices to ensure the reliability of their equipment. Alarm systems and protective relaying safeguard against most problems. However, often permanent damage has already occurred when these systems operate. As technology develops so does the ability to suppress unexpected outages and equipment damage. In many cases an equipment problem manifests itself by the radiation of excess heat energy. The detection and analysis of this heating is becoming a major factor in predictive maintenance programs. This paper describes how thermography is a cost-effective tool to provide reliable service. This technology can work for the pipe line industry just as well as the utility industry.

  7. Heavy Equipment Mechanic Program Standards.

    ERIC Educational Resources Information Center

    Georgia Univ., Athens. Dept. of Vocational Education.

    This publication contains statewide standards for the heavy equipment mechanic program in Georgia. The standards are divided into 12 categories: foundations (philosophy, purpose, goals, program objectives, availability, evaluation); admissions (admission requirements, provisional admission requirements, recruitment, evaluation and planning);…

  8. Water-Using Equipment: Domestic

    SciTech Connect

    Solana, Amy E.; Mcmordie, Katherine

    2006-01-24

    Water management is an important aspect of energy engineering. This article addresses water-using equipment primarily used for household purposes, including faucets, showers, toilets, urinals, dishwashers, and clothes washers, and focuses on how the equipment can be optimized to save both water and energy. Technology retrofits and operation and maintenance changes are the primary methods discussed for water and energy conservation. Auditing to determine current consumption rates is also described for each technology.

  9. Equipping the exotic mammal practice.

    PubMed

    Fisher, Peter G

    2005-09-01

    Many tools used in small animal practice can be adapted for use with exotic mammals. For those veterinarians with a strong interest in exotic mammals, specific equipment and supply needs need to be taken under consideration. Initial investment need not be great to get started with special species, and as the practice develops more specialized equipment can be added. Starting with equipment that aids in patient husbandry, diagnostic sampling, and routine hospital medical and surgical care is very helpful in creating confidence and expertise with these species. As the practice case load grows more sophisticated, equipment can be added, allowing for better diagnostic workups, medical treatment, and surgical care. The right equipment for the right job makes for a more rewarding and efficient exotic mammal practice. The author describes equipment and products (Table 1) he routinely uses in his private practice, and has provided a list of available sources. Readers should keep in mind that this list is not all-inclusive, and that in many instances products discussed can be found from multiple veterinary distributors or vendors. The author does not promote or recommend one supplier or manufacturer over another. PMID:16129350

  10. Rig safety depends on equipment, regulations, and personnel

    SciTech Connect

    Bates, T.R. Jr.; Tait, S. ); Mumford, G. )

    1990-03-05

    The authors discuss how improvements that can increase rig safety can be made in equipment, regulations, and stabilized personnel levels. With regard to equipment, exposure to material handling must be reduced through automation, and well-control technology must be improved by enhanced use of computers and better systems to handle gas. According to this analysis, regulations are needed that are global in scope and have had their costs-to-benefits fully and fairly assessed. Self regulation must be used effectively throughout the industry. Job security and wages should be made adequate to maintain an experienced, motivated, and safe work force.

  11. Essentialism: Common Sense Quality Improvement.

    ERIC Educational Resources Information Center

    Wallin, Desna L.; Ryan, John R.

    Essentialism is a trimmed down, action-oriented, user-friendly approach to Total Quality Management (TQM) in education. This book explores the concept of essentialism to describe strategies for implementing TQM in community colleges. Chapter 1 examines the history of the TQM movement and reviews experiences of community college practitioners…

  12. Information management: an HMO essential.

    PubMed

    Egerman, P; Heineman, S

    1990-01-01

    Health maintenance organizations (HMO), with their diverse audiences and complex operations, offer the best proof that management information systems (MIS) are emerging as an essential and marketable business asset. Authors Paul Egerman and Susan Heineman offer many uses for a good MIS and why such a program is essential to an HMO's success. PMID:10103557

  13. RTI Essential Components Integrity Rubric

    ERIC Educational Resources Information Center

    National Center on Response to Intervention, 2011

    2011-01-01

    The Response to Intervention (RTI) Essential Components Integrity Rubric is for use by individuals who are responsible for monitoring school-level fidelity of RTI implementation. The rubric is aligned with "Essential Components of RTI: A Closer Look at Response to Intervention" (National Center on Response to Intervention, 2010). Subjects covered…

  14. Recommended Minimal Emergency Equipment and Resources for Schools: National Consensus Group Report

    ERIC Educational Resources Information Center

    Bobo, Nichole; Hallenbeck, Paula; Robinson, Judith

    2003-01-01

    Providing an environment that is responsive to emergency health needs of students is essential to creating a safe setting for children in schools. The question of what minimal essential emergency equipment and resources should be available in schools brings with it many and varied opinions, issues, and concerns. Through funding from the Emergency…

  15. Hyperbaric intensive care technology and equipment.

    PubMed

    Millar, Ian L

    2015-03-01

    In an emergency, life support can be provided during recompression or hyperbaric oxygen therapy using very basic equipment, provided the equipment is hyperbaric-compatible and the clinicians have appropriate experience. For hyperbaric critical care to be provided safely on a routine basis, however, a great deal of preparation and specific equipment is needed, and relatively few facilities have optimal capabilities at present. The type, size and location of the chamber are very influential factors. Although monoplace chamber critical care is possible, it involves special adaptations and inherent limitations that make it inappropriate for all but specifically experienced teams. A large, purpose-designed chamber co-located with an intensive care unit is ideal. Keeping the critically ill patient on their normal bed significantly improves quality of care where this is possible. The latest hyperbaric ventilators have resolved many of the issues normally associated with hyperbaric ventilation, but at significant cost. Multi-parameter monitoring is relatively simple with advanced portable monitors, or preferably installed units that are of the same type as used elsewhere in the hospital. Whilst end-tidal CO₂ readings are changed by pressure and require interpretation, most other parameters display normally. All normal infusions can be continued, with several examples of syringe drivers and infusion pumps shown to function essentially normally at pressure. Techniques exist for continuous suction drainage and most other aspects of standard critical care. At present, the most complex life support technologies such as haemofiltration, cardiac assist devices and extra-corporeal membrane oxygenation remain incompatible with the hyperbaric environment. PMID:25964040

  16. 1968 Listing of Swimming Pool Equipment.

    ERIC Educational Resources Information Center

    National Sanitation Foundation, Ann Arbor, MI. Testing Lab.

    An up-to-date listing of swimming pool equipment including--(1) companies authorized to display the National Sanitation Foundation seal of approval, (2) equipment listed as meeting NSF swimming pool equipment standards relating to diatomite type filters, (3) equipment listed as meeting NSF swimming pool equipment standard relating to sand type…

  17. 40 CFR 264.32 - Required equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... equipment (including special extinguishing equipment, such as that using foam, inert gas, or dry chemicals), spill control equipment, and decontamination equipment; and (d) Water at adequate volume and pressure to supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems....

  18. 40 CFR 65.103 - Equipment identification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Equipment Leaks § 65.103 Equipment identification. (a) General... leak is detected. (ii) The owner or operator of equipment designated as difficult-to-monitor according... procedures in § 65.105 if a leak is detected. (d) Special equipment designations: Equipment that is unsafe...

  19. 40 CFR 65.103 - Equipment identification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Equipment Leaks § 65.103 Equipment identification. (a) General... leak is detected. (ii) The owner or operator of equipment designated as difficult-to-monitor according... procedures in § 65.105 if a leak is detected. (d) Special equipment designations: Equipment that is unsafe...

  20. 40 CFR 65.103 - Equipment identification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Equipment Leaks § 65.103 Equipment identification. (a) General... leak is detected. (ii) The owner or operator of equipment designated as difficult-to-monitor according... procedures in § 65.105 if a leak is detected. (d) Special equipment designations: Equipment that is unsafe...

  1. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  2. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  3. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  4. Equipment Efficiency for Healthy School Meals. [Videotape].

    ERIC Educational Resources Information Center

    National Food Service Management Inst., University, MS.

    A satellite seminar on large-scale food production equipment discusses ways child nutrition personnel can maximize use of existing equipment, considers research related to use of existing equipment, explains plan reviews for equipment selection and purchase, and explores new equipment options. Examples illustrate use of planning or modernizing…

  5. Equipment Efficiency for Healthy School Meals. [Videotape].

    ERIC Educational Resources Information Center

    National Food Service Management Inst., University, MS.

    A satellite seminar on large-scale food production equipment discusses ways child nutrition personnel can maximize use of existing equipment, considers research related to use of existing equipment, explains plan reviews for equipment selection and purchase, and explores new equipment options. Examples illustrate use of planning or modernizing

  6. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  7. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  8. Automatic stabilization

    NASA Technical Reports Server (NTRS)

    Haus, FR

    1936-01-01

    This report concerns the study of automatic stabilizers and extends it to include the control of the three-control system of the airplane instead of just altitude control. Some of the topics discussed include lateral disturbed motion, static stability, the mathematical theory of lateral motion, and large angles of incidence. Various mechanisms and stabilizers are also discussed. The feeding of Diesel engines by injection pumps actuated by engine compression, achieves the required high speeds of injection readily and permits rigorous control of the combustible charge introduced into each cylinder and of the peak pressure in the resultant cycle.

  9. Personal protective equipment and decontamination of adults and children.

    PubMed

    Holland, Michael G; Cawthon, David

    2015-02-01

    Accurate identification of the hazardous material is essential for proper care. Efficient hospital security and triage must prevent contaminated victims from entering the emergency department (ED) and causing secondary contamination. The decontamination area should be located outside the ambulance entrance. Decontamination priorities are protection of the health care worker, utilization of Level C personal protective equipment, and proper decontamination of the exposed patient. Decontamination proceeds in a head-to-toe sequence. Run-off water is a hazardous waste. Hospital and Community Management Planning for these emergencies is essential for proper preparation and effective response to the hazardous materials incident. PMID:25455662

  10. Neuroimaging essentials in essential tremor: A systematic review

    PubMed Central

    Sharifi, Sarvi; Nederveen, Aart J.; Booij, Jan; vanRootselaar, Anne-Fleur

    2014-01-01

    Background Essential tremor is regarded to be a disease of the central nervous system. Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and research. The exact role of imaging techniques with respect to essential tremor in research and clinical practice is not clear. A systematic review of the different imaging techniques in essential tremor is lacking in the literature. Methods We performed a systematic literature search combining the terms essential tremor and familial tremor with the following keywords: imaging, MRI, VBM, DWI, fMRI, PET and SPECT, both in abbreviated form as well as in full form. We summarize and discuss the quality and the external validity of each study and place the results in the context of existing knowledge regarding the pathophysiology of essential tremor. Results A total of 48 neuroimaging studies met our search criteria, roughly divided into 19 structural and 29 functional and metabolic studies. The quality of the studies varied, especially concerning inclusion criteria. Functional imaging studies indicated cerebellar hyperactivity during rest and during tremor. The studies also pointed to the involvement of the thalamus, the inferior olive and the red nucleus. Structural studies showed less consistent results. Discussion and conclusion Neuroimaging techniques in essential tremor give insight into the pathophysiology of essential tremor indicating the involvement of the cerebellum as the most consistent finding. GABAergic dysfunction might be a major premise in the pathophysiological hypotheses. Inconsistencies between studies can be partly explained by the inclusion of heterogeneous patient groups. Improvement of scientific research requires more stringent inclusion criteria and application of advanced analysis techniques. Also, the use of multimodal neuroimaging techniques is a promising development in movement disorders research. Currently, the role of imaging techniques in essential tremor in daily clinical practice is limited. PMID:25068111

  11. Preparation and characterization of clove essential oil-loaded liposomes.

    PubMed

    Sebaaly, Carine; Jraij, Alia; Fessi, Hatem; Charcosset, Catherine; Greige-Gerges, Hélène

    2015-07-01

    In this study, suitable formulations of natural soybean phospholipid vesicles were developed to improve the stability of clove essential oil and its main component, eugenol. Using an ethanol injection method, saturated (Phospholipon 80H, Phospholipon 90H) and unsaturated soybean (Lipoid S100) phospholipids, in combination with cholesterol, were used to prepare liposomes at various eugenol and clove essential oil concentrations. Liposomal batches were characterized and compared for their size, polydispersity index, Zeta potential, loading rate, encapsulation efficiency and morphology. The liposomes were tested for their stability after storing them for 2 months at 4°C by monitoring changes in their mean size, polydispersity index and encapsulation efficiency (EE) values. It was found that liposomes exhibited nanometric oligolamellar and spherical shaped vesicles and protected eugenol from degradation induced by UV exposure; they also maintained the DPPH-scavenging activity of free eugenol. Liposomes constitute a suitable system for encapsulation of volatile unstable essential oil constituents. PMID:25704683

  12. Membrane stabilizer

    DOEpatents

    Mingenbach, W.A.

    1988-02-09

    A device is provided for stabilizing a flexible membrane secured within a frame, wherein a plurality of elongated arms are disposed radially from a central hub which penetrates the membrane, said arms imposing alternately against opposite sides of the membrane, thus warping and tensioning the membrane into a condition of improved stability. The membrane may be an opaque or translucent sheet or other material. 10 figs.

  13. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a medicated feed of intended potency and purity, and shall...

  14. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a medicated feed of intended potency and purity, and shall...

  15. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a medicated feed of intended potency and purity, and shall...

  16. 40 CFR 265.32 - Required equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Portable fire extinguishers, fire control equipment (including special extinguishing equipment, such as...; and (d) Water at adequate volume and pressure to supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems....

  17. 40 CFR 265.32 - Required equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Portable fire extinguishers, fire control equipment (including special extinguishing equipment, such as...; and (d) Water at adequate volume and pressure to supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems....

  18. 40 CFR 265.32 - Required equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Portable fire extinguishers, fire control equipment (including special extinguishing equipment, such as...; and (d) Water at adequate volume and pressure to supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems....

  19. In rat dipeptidyl peptidase III, His⁵⁶⁸ is essential for catalysis, and Glu⁵⁰⁷ or Glu⁵¹² stabilizes the coordination bond between His⁴⁵⁵ or His⁴⁵⁰ and zinc ion.

    PubMed

    Fukasawa, Kayoko M; Hirose, Junzo; Hata, Toshiyuki; Ono, Yukio

    2010-10-01

    Dipeptidyl peptidase (DPP) III is a zinc-dependent exopeptidase that has a unique motif, "HELLGH," as the zinc-binding site. In the present study, a three-dimensional (3D) model of rat DPP III was generated with the X-ray crystal structure of human DPP III (PDB: 3FVY [Dobrovetsky E. et al. (2009) SGC]) as a template. The replacement of the seven charged amino acid residues with a hydrophobic amino acid around the zinc ion did not cause any significant changes in K(m) values or in the substrate specificity. However, the k(cat) values of H568R and H568Y were remarkably reduced, by factors of 50 and 400, respectively. The His⁵⁶⁸ residue of rat DPP III is essential for enzyme catalysis. The k(cat) values of the mutants E507A and E512A were 2.38 and 3.88 s⁻¹ toward Arg-Arg-NA, and 0.097 and 0.59 s⁻¹ toward Phe-Arg-NA, respectively. These values were markedly lower than those of the wild-type DPP III. Furthermore, the zinc contents of E507A and E512A were 0.29 and 0.08 atom per mol of protein, respectively, and those mutations caused remarkable increases in the dissociation constants of the zinc ions from DPP III by factors of 5 x 10³ to 2 x 10⁴. The 3D model of the catalytic domain of rat DPP III showed that the carboxyl oxygen atoms of Glu⁵⁰⁷ and Glu⁵¹² form the hydrogen bonds to the nitrogen atoms of His⁴⁵⁵ and His⁴⁵⁰. All of these results showed that Glu⁵⁰⁷ or Glu⁵¹² stabilizes the coordination bond between the zinc ion and His⁴⁵⁵ or His⁴⁵⁰. PMID:20601226

  20. Stabilizing Microwave Frequency of a Photonic Oscillator

    NASA Technical Reports Server (NTRS)

    Maleki, Lute; Yu, Nan; Tu, Meirong

    2006-01-01

    A scheme for stabilizing the frequency of a microwave signal is proposed that exploits the operational characteristics of a coupled optoelectronic oscillator (COEO) and related optoelectronic equipment. An essential element in the scheme is a fiber mode-locked laser (MLL), the optical frequency of which is locked to an atomic transition. In this scheme, the optical frequency stability of the mode-locked laser is transferred to that of the microwave in the same device. Relative to prior schemes for using wideband optical frequency comb to stabilize microwave signals, this scheme is simpler and lends itself more readily to implementation in relatively compact, rugged equipment. The anticipated development of small, low-power, lightweight, highly stable microwave oscillators based on this scheme would afford great benefits in communication, navigation, metrology, and fundamental sciences. COEOs of various designs, at various stages of development, in some cases called by different names, have been described in a number of prior NASA Tech Briefs articles. A COEO is an optoelectronic apparatus that generates both short (picosecond) optical pulses and a steady microwave signal having an ultrahigh degree of spectral purity. The term "coupled optoelectronic" in the full name of such an apparatus signifies that its optical and electronic oscillations are coupled to each other in a single device. The present frequency-stabilization scheme is best described indirectly by describing the laboratory apparatus used to demonstrate it. The apparatus (see figure) includes a COEO that generates a comb-like optical spectrum, the various frequency components of which interfere, producing short optical pulses. This spectrum is centered at a nominal wavelength of 1,560 nm. The spectrum separation of this comb is about 10 GHz, as determined primarily by the length of an optical loop and the bandpass filter in the microwave feedback loop. The optical loop serves as microwave resonator having a very high value of the resonance quality factor (Q). The optical frequency of MLL is then stabilized by locking it to an atomic transition as described below. The COEO contains a tunable 1-nm band-pass optical filter and a piezoelectric-transducer (PZT) drum over which a stretch of fiber is wound. The 1-nm-wide pass band of the filter provides coarse tuning to overlap the frequency comb with the atomic transition frequency. Controlled stretching of the fiber by means of the PZT drum can be used in conjunction with temperature control for locking the laser frequency. To reference to an atomic resonance at 780 nm in this demonstration setup, the optical output of the COEO at 1,560 nm is fed through an erbium-doped-fiber amplifier (EDFA) to a frequency doubler in the form of a periodically poled lithium niobate (PPLN) crystal. The frequency-doubled output is combined with the output of a separate frequency-stabilized diode laser at a photodetector. As described thus far, the two 780-nm laser subsystems are nominally independent of each other and can, therefore, operate at different frequencies. Hence, at the photodetector, the two laser beams interfere, so that the output of the photodetector includes a beat note (a component at the difference between the two laser frequencies).

  1. Remote welding equipment for TPX

    SciTech Connect

    Silke, G.W.; Junge, R.

    1995-12-31

    Remote welding equipment and techniques are necessary for maintenance of the Tokamak Physics Experiment (TPX) Plasma Facing Components (PFCs). The processes identified for this application includes inside diameter (i.d.) and outside diameter (o.d.) Gas Tungsten Arc (GTA) welding of titanium and stainless steel alloys. Welding equipment developed for this application includes some unique features due to the specialized environment of the TPX vessel. Remote features of this equipment must include the ability to acquire and align the parts being welded, perform all welding operations and visually inspect the weld area. Designs for weld heads require the integration of industry proven hardware with the special features include compact size, remote manipulation, remote clamping and alignment, remote vision, full inert gas coverage, arc voltage control, wire feed, programmable weld schedules and failure recovery.

  2. The choice of homogenisation equipment affects lipid oxidation in emulsions.

    PubMed

    Horn, Anna Frisenfeldt; Nielsen, Nina Skall; Jensen, Louise Søgaard; Horsewell, Andy; Jacobsen, Charlotte

    2012-09-15

    Milk proteins are often used by the food industry because of their good emulsifying properties. In addition, they can also provide oxidative stability to foods. However, different milk proteins or protein components have been shown to differ in their antioxidative properties, and their localisation in emulsions has been shown to be affected by the emulsification conditions. The objective of this study was to investigate the influence of homogenisation equipment (microfluidizer vs. two-stage valve homogeniser) on lipid oxidation in 10% fish oil-in-water emulsions prepared with two different milk proteins. Emulsions were prepared at pH 7 with similar droplet sizes. Results showed that the oxidative stability of emulsions prepared with sodium caseinate was not influenced by the type of homogeniser used. In contrast, the type of homogenisation equipment significantly influenced lipid oxidation when whey protein was used as emulsifier, with the microfluidizer resulting in lower levels of oxidation. PMID:23107694

  3. Power Product Equipment Technician: Construction Equipment. Teacher Edition. Student Edition.

    ERIC Educational Resources Information Center

    Hilley, Robert

    The instructor's guide in this package, which is one in a series of new publications developed to replace the Multistate Academic and Vocational Curriculum Consortium's previous small-engine curricula, contains the materials required to teach a competency-based course in repairing construction equipment. The guide begins with an introduction…

  4. Heavy Equipment Operator: General Equipment Operator. Instructional Materials.

    ERIC Educational Resources Information Center

    Hendrix, Laborn J.; Sawatzky, Joyce

    Developed through close coordination between contractors, construction workers, and vocational educators, this instructor's manual is designed to help heavy equipment instructors present materials in a systematic format. The instructional materials in the manual are written in terms of student performance, using measurable behavioral objectives.…

  5. Equipping the Open-Plan School, Equipping for Open Education.

    ERIC Educational Resources Information Center

    Lassiter, Frank

    The performance specifications of furniture and equipment for open education and open-plan schools differ from conventional classroom furniture in that it must be easily moved, have a range of dimensions, contain multipurpose interchangeable components, and be designed to accommodate a variety of student/teacher uses. The author suggests some…

  6. Essential Oils, Part I: Introduction.

    PubMed

    de Groot, Anton C; Schmidt, Erich

    2016-01-01

    Essential oils are widely used in the flavor, food, fragrance, and cosmetic industries in many applications. Contact allergy to them is well known and has been described for 80 essential oils. The relevance of positive patch test reactions often remains unknown. Knowledge of the chemical composition of essential oils among dermatologists is suspected to be limited, as such data are published in journals not read by the dermatological community. Therefore, the authors have fully reviewed and published the literature on contact allergy to and chemical composition of essential oils. Selected topics from this publication will be presented in abbreviated form in Dermatitis starting with this issue, including I. Introduction; II. General aspects; III. Chemistry; IV. General aspects of contact allergy; V. Peppermint oil, lavender oil and lemongrass oil; VI: Sandalwood oil, ylang-ylang oil, and jasmine absolute. PMID:26983089

  7. Essential Tremor (ET): Surgical Options

    MedlinePlus

    ... surgical options for ET include deep brain stimulation (DBS) and thalamotomy. Potential candidates for surgical procedures are ... Essential Tremor: Deep Brain Stimulation Deep brain stimulation (DBS) surgery is an FDA-approved treatment that has ...

  8. Essential Elements of Geologic Reports.

    ERIC Educational Resources Information Center

    Webb, Elmer James

    1988-01-01

    Described is a report outline for geologic reports. Essential elements include title; abstract; introduction; stratigraphy; petrography; geochemistry; petrology; geophysics; structural geology; geologic history; modeling; economics; conclusions; and recommendations. (Author/CW)

  9. Trends in medical equipment service.

    PubMed

    1997-06-01

    Driven by the recent emphasis on cost containment in the healthcare industry as a whole, hospitals, manufacturers, and service providers have been spurred to try to find ways to reduce their costs and increase their revenues. As a result of the measures taken to achieve these goals, the medical equipment service industry has been experiencing a period of rapid change. In this environment, traditional alternatives for servicing medical equipment are being challenged, and new alternatives are being developed. The changes occurring in this industry are of vital interest to clinical engineers and technicians because it is those changes that will determine the future role of these professionals in the hospital. While such technology experts will not become obsolete-the reliance on medical technology to provide optimal healthcare will certainly continue in the United States and throughout the rest of the developed world-the roles of these experts could very likely change. As hospitals focus more narrowly on their core functions, noncore functions such as servicing and managing technology will come under scrutiny as possible candidates for outsourcing to reduce the hospital's administrative responsibilities and cut its cost burden. In this article, we review the recent past of the medical equipment service industry and describe some current trends that will play a role in shaping the future of this industry. We also discuss how the changes currently taking place will likely affect the viability of in-house clinical engineering departments. In our discussion, we spotlight service issues related to radiology equipment because (1) this equipment dominates service expenditures and (2) the servicing of these devices has spawned some of the changes causing hospitals to reexamine how all their medical equipment is being serviced and managed. PMID:9199958

  10. Steps of Reprocessing and Equipments

    PubMed Central

    Lee, Yong Kook

    2013-01-01

    With the increasing interest in endoscopy and the rising number of endoscopic examinations in hospitals, the importance of endoscopic reprocessing is also increasing. Cure facilities that are understaffed and ill-equipped are trying to cope with the problems of insufficient cleaning and high infection risks. To prevent endoscopy-associated infection, the endoscope cleaning, and disinfection guidelines prepared by the Korean Society of Gastrointestinal Endoscopy must be followed. In this review, the steps of endoscopic reprocessing and the equipments required in each step are discussed. PMID:23767039

  11. Robot Would Reconfigure Modular Equipment

    NASA Technical Reports Server (NTRS)

    Purves, Lloyd R.

    1993-01-01

    Special-purpose sets of equipment, packaged in identical modules with identical interconnecting mechanisms, attached to or detached from each other by specially designed robot, according to proposal. Two-arm walking robot connects and disconnects modules, operating either autonomously or under remote supervision. Robot walks along row of connected modules by grasping successive attachment subassemblies in hand-over-hand motion. Intended application for facility or station in outer space; robot reconfiguration scheme makes it unnecessary for astronauts to venture outside spacecraft or space station. Concept proves useful on Earth in assembly, disassembly, or reconfiguration of equipment in such hostile environments as underwater, near active volcanoes, or in industrial process streams.

  12. Advanced deep sea diving equipment

    NASA Technical Reports Server (NTRS)

    Danesi, W. A.

    1972-01-01

    Design requirements are generated for a deep sea heavy duty diving system to equip salvage divers with equipment and tools that permit work of the same quality and in times approaching that done on the surface. The system consists of a helmet, a recirculator for removing carbon dioxide, and the diver's dress. The diver controls the inlet flow by the recirculatory control valve and is able to change closed cycle operation to open cycle if malfunction occurs. Proper function of the scrubber in the recirculator minimizes temperature and humidity effects as it filters the returning air.

  13. Shuttle extravehicular life support equipment

    NASA Technical Reports Server (NTRS)

    Sutton, J. G.

    1973-01-01

    A Shuttle EVA/IVA Requirements Study was conducted by Hamilton Standard for NASA. The objectives of this study were to establish a baseline EVA approach for Shuttle and to prepare requirements for the EVA equipment required to support these operations. This paper presents the results of the EVA life support requirements definition effort and defines candidate configurations which meet these requirements. Various subsystem and system concepts were identified and evaluated to determine the most desirable approaches. Both independent and umbilical configurations are considered. Because certain EVA missions could involve contamination-sensitive payloads, the impact of integrating noncontaminating equipment is also considered.

  14. Essential Spaceflight Dynamics and Magnetospherics

    NASA Astrophysics Data System (ADS)

    Rauschenbakh, B. V.; Ovchinnikov, M. Yu.; McKenna-Lawlor, S.

    2002-12-01

    The present book Essential Spaceflight Dynamics and Magnetospherics describes, in the first instance, some of the key aspects of celestial mechanics and spaceflight dynamics. It begins with classical two- and three-body problems illustrative of the aesthetic aspects of applying analytical methods of investigation to celestial mechanics. Then, osculating orbital elements are introduced as well as analysis techniques sufficient to evaluate the influence of various disturbing forces on spacecraft. Next a theory of manoeuvres is outlined and the methodology of making interplanetary trajectory corrections. Ideas involving various approaches to orbital element determinations using measured data are also considered. The forces applied to a spacecraft can result in the development of torques that influence attitude motion and the effects of the most important of these are described in terms of equilibrium positions, periodic motions, steady-state and transient motions. Also considered is the problem of attitude control of a spacecraft using active and/or passive methods of orientation and stabilization. In addition, a more advanced treatment of the development of attitude control systems is provided. A description of the Earth's magnetic and gravitational fields allows clarification of the relationship between natural features of the Earth's environment and the requirements of mission design, orbit construction and approaches to attitude control. A detailed Addendum provides an overview of circumstances on the Sun that render interplanetary space a very hazardous environment for spacecraft and for `man in space'. The influence of this environment on spacecraft performance and survival is then presented, together with an outline of some of the mitigating strategies that can be invoked. A feature of this Addendum is the indication it provides of the challenges that the next generation of space experiments will pose to mission designers. It is accompanied by a separate set of references since if refers to ongoing work in space physics rather than to classical material. Rauschenbakh, Boris Victorovich (1915-2001). Doctor of Technical Science, Member of the Russian Academy of Sciences and the International Academy of Astronautics. One of the founders of practical cosmonautics in Russia. Worked in the `Energia' Enterprise with Sergey Koroljev and later occupied the Chair of Theoretical Mechanics at the Moscow Institute of Physics and Technology. Ovchinnikov, Michael Yurjevich, Doctor of Science in Physics and Mathematics at the Keldysh Institute of Applied Mathematics of the Russian Academy of Sciences and also a Professor at the Moscow Institute of Physics and Technology. Expert in mechanics, spaceflight dynamics and attitude control for small satellites. McKenna-Lawlor, Susan, Emeritus Professor at the National University of Ireland, Maynooth. Guest Professor of the Chinese Academy of Sciences. Doctorate in Space Physics. Director of Space Technology Ireland, Ltd. Pioneering experiments flown on European, American, Russian and Chinese Space Agency Missions. Member of the International Academy of Astronautics. Recipient of the Tsiolkovsky Medal for Cosmonautics. Link: http://www.wkap.nl/prod/b/1-4020-1063-X

  15. Equipment

    ERIC Educational Resources Information Center

    Education in Chemistry, 1976

    1976-01-01

    Described are a number of publications and items for use in chemistry. Included are brief descriptions of actuators, thermometer strips, current balances, and a variety of catalogues and other publications. (RH)

  16. Astronaut Alan Bean flies the Astronaut Maneuvering Equipment

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Astronaut Alan L. Bean, Skylab 3 commander, flies the M509 Astronaut Maneuvering Equipment in the forward dome area of the Orbital Workshop (OWS) on the space station cluster in Earth orbit. Bean is strapped in to the back-mounted, hand-controlled Automatically Stabilized Maneuvering Unit (ASMU). This ASMU exerperiment is being done in shirt sleeves. The dome area where the experiment is conducted is about 22 feet in diameter and 19 feet from top to bottom.

  17. Astronaut Alan Bean flies the Astronaut Maneuvering Equipment

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Astronaut Alan L. Bean, Skylab 3 commander, flies the M509 Astronaut Maneuvering Equipment in the foreward dome area of the Orbital Workshop (OWS) on the space station cluster in Earth orbit. Bean is strapped in to the back-mounted, hand-controlled Automatically Stabilized Maneuvering Unit (ASMU). This ASMU exerperiment is being done in shirt sleeves. The dome area where the experiment is conducted is about 22 feet in diameter and 19 feet from top to bottom.

  18. A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

    PubMed Central

    Zhang, Y. Ping; Shields, Lisa B. E.; Shields, Christopher B.; Xu, Xiao-Ming

    2015-01-01

    Clinically-relevant animal cervical spinal cord injury (SCI) models are essential for developing and testing potential therapies; however, producing reliable cervical SCI is difficult due to lack of satisfactory methods of vertebral stabilization. The conventional method to stabilize the spine is to suspend the rostral and caudal cervical spine via clamps attached to cervical spinous processes.  However, this method of stabilization fails to prevent tissue yielding during the contusion as the cervical spinal processes are too short to be effectively secured by the clamps (Figure 1).  Here we introduce a new method to completely stabilize the cervical vertebra at the same level of the impact injury.  This method effectively minimizes movement of the spinal column at the site of impact, which greatly improves the production of consistent SCIs.  We provide visual description of the equipment (Figure 2-4), methods, and a step-by-step protocol for the stabilization of the cervical 5 vertebra (C5) of adult rats, to perform laminectomy (Figure 5) and produce a contusive SCI thereafter.  Although we only demonstrate a cervical hemi-contusion using the NYU/MASCIS impactor device, this vertebral stabilization technique can be applied to other regions of the spinal cord, or be adapted to other SCI devices.  Improving spinal cord exposure and fixation through vertebral stabilization may be valuable for producing consistent and reliable injuries to the spinal cord.  This vertebral stabilization method can also be used for stereotactic injections of cells and tracers, and for imaging using two-photon microscopy in various neurobiological studies. PMID:25590284

  19. Preventive Maintenance Handbook. Audiovisual Equipment.

    ERIC Educational Resources Information Center

    Educational Products Information Exchange Inst., Stony Brook, NY.

    The preventive maintenance system for audiovisual equipment presented in this handbook is designed by specialists so that it can be used by nonspecialists in school sites. The report offers specific advice on saftey factors and also lists major problems that should not be handled by nonspecialists. Other aspects of a preventive maintenance system…

  20. Multimedia Equipment for Distance Education.

    ERIC Educational Resources Information Center

    Schiller, Scott S.

    1993-01-01

    Discusses the use of multimedia equipment for distance education. Topics addressed include use of the Internet; distance learning for educators; and cable television and/or fiber optics, including interactive television and satellite technology. A sidebar lists online and telecommunications providers. (LRW)

  1. Strategy Guideline. HVAC Equipment Sizing

    SciTech Connect

    Burdick, Arlan

    2012-02-01

    This guide describes the equipment selection of a split system air conditioner and furnace for an example house in Chicago, IL as well as a heat pump system for an example house in Orlando, FL. The required heating and cooling load information for the two example houses was developed in the Department of Energy Building America Strategy Guideline: Accurate Heating and Cooling Load Calculations.

  2. Using Gaming Equipment to Teach

    ERIC Educational Resources Information Center

    Curriculum Review, 2009

    2009-01-01

    Gaming equipment (such as Nintendo's Wii[TM]) is making its way to schools and classrooms. However, most of the discussion regarding how to use this technology and integrate it into lesson plans is happening in blogs on the Internet. An advocate of interactive media in the classroom, Dr. Dawn Hawkins, a faculty member for the Art Institute of…

  3. Lawn and Garden Equipment Repair.

    ERIC Educational Resources Information Center

    Hardway, Jack; And Others

    This publication is designed to supplement the Comprehensive Small Engine Rapair guide by covering in detail all aspects of lawn and garden equipment repair not included in general engine repair or the repair of other small engines. It consists of instructional materials for both teachers and students, written in terms of student performance using…

  4. Computer Equipment Repair Curriculum Guide.

    ERIC Educational Resources Information Center

    Reneau, Fred; And Others

    This guide is intended for use in a course to train students to repair computer equipment and perform related administrative and customer service tasks. Addressed in the individual units are the following topics (with selected subtopics in brackets): performing administrative functions (preparing service bills, maintaining accounts and labor…

  5. Fundamentals of microelectronic equipment design

    NASA Astrophysics Data System (ADS)

    Nenashev, A. P.; Koledov, L. A.

    Microelectronic equipment design is reviewed with reference to general design principles and criteria, role of standardization, design of microcircuit components, and assembly techniques. Particular attention is given to the design of hybrid integrated circuitry and discrete radioelectronic components. Design methods for providing adequate temperature conditions and protection from humidity and mechanical overloads as well as component layout criteria are also discussed.

  6. Heating and Cooling Equipment Selection

    SciTech Connect

    Not Available

    2002-01-01

    This is one of a series of technology fact sheets created to help housing designers and builders adopt a whole-house design approach and energy efficient design practices. The fact sheet helps people choose the correct equipment for heating and cooling to reduce initial costs, increase homeowner comfort, increase operating efficiency, and greatly reduce utility costs.

  7. Is Equipment Management Really Neccessary

    NASA Technical Reports Server (NTRS)

    Tavernier, James P.

    1996-01-01

    This workshop is designed to foster an initiative for intelligent Equipment Management employing the advances in information systems and opportunities uncovered by the reengineering process. The guiding concept behind the initiative is that both contributions and benefits must be equitable and balanced for all participants.

  8. Housing, Home Furnishings, and Equipment.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    Designed for use in consumer and homemaking education in Texas, this curriculum guide is on the subject of housing, home furnishings, and equipment. An introduction to the guide, covering its use and program and curriculum planning, provides a list of suggested readings. Information on teaching handicapped and disadvantaged students follows. The…

  9. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment § 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  10. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment § 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  11. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment § 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  12. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment § 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  13. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Equipment design. 792.61 Section 792... (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  14. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Equipment design. 792.61 Section 792... (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  15. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment § 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  16. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment § 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  17. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false Equipment design. 792.61 Section 792... (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  18. 10 CFR 431.404 - Imported equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Imported equipment. 431.404 Section 431.404 Energy... EQUIPMENT General Provisions § 431.404 Imported equipment. (a) Under sections 331 and 345 of the Act, any person importing any covered equipment into the United States must comply with the provisions of the...

  19. 10 CFR 431.404 - Imported equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Imported equipment. 431.404 Section 431.404 Energy... EQUIPMENT General Provisions § 431.404 Imported equipment. (a) Under sections 331 and 345 of the Act, any person importing any covered equipment into the United States must comply with the provisions of the...

  20. 7 CFR 58.626 - Packaging equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Packaging equipment. 58.626 Section 58.626 Agriculture....626 Packaging equipment. Packaging equipment designed to mechanically fill and close single service... Standards for Equipment for Packaging Frozen Desserts and Cottage Cheese. Quality Specifications for...

  1. 7 CFR 58.626 - Packaging equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Packaging equipment. 58.626 Section 58.626 Agriculture....626 Packaging equipment. Packaging equipment designed to mechanically fill and close single service... Standards for Equipment for Packaging Frozen Desserts and Cottage Cheese. Quality Specifications for...

  2. Energy-related laboratory equipment (ERLE) guidelines

    SciTech Connect

    Not Available

    1995-01-01

    This document describes the Used Energy-Related Laboratory Equipment grants, and eligibility and procedures for participation. The document contains tables identifying typical equipment that may be requested, where to review ERLE equipment lists, and where to mail applications, a description of the eligible equipment grants access data system, and a copy of the ERLE grant application and instructions for its completion and submission.

  3. 47 CFR 18.203 - Equipment authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Equipment authorization. 18.203 Section 18.203 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INDUSTRIAL, SCIENTIFIC, AND MEDICAL EQUIPMENT Applications and Authorizations § 18.203 Equipment authorization. (a) Consumer ISM equipment, unless otherwise specified, must be...

  4. 21 CFR 211.65 - Equipment construction.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment construction. 211.65 Section 211.65 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Equipment § 211.65 Equipment construction. (a) Equipment shall be...

  5. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment § 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  6. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Equipment design. 792.61 Section 792... (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  7. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Equipment design. 792.61 Section 792.61...) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  8. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment § 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  9. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment § 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  10. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment § 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  11. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. (a) In showing compliance with § 23.1309(b)(1) and (2) with respect to radio and electronic equipment and their installations, critical environmental conditions...

  12. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. (a) In showing compliance with § 23.1309(b)(1) and (2) with respect to radio and electronic equipment and their installations, critical environmental conditions...

  13. 40 CFR 63.1003 - Equipment identification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) National Emission Standards for Equipment Leaks-Control Level 1 § 63.1003 Equipment identification. (a... applicable, and repair of the equipment according to the procedures in § 63.1005 if a leak is detected. (ii... leak is detected. (d) Special equipment designations: Unsafe-to-repair—(1) Designation and...

  14. 40 CFR 63.1003 - Equipment identification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) National Emission Standards for Equipment Leaks-Control Level 1 § 63.1003 Equipment identification. (a... applicable, and repair of the equipment according to the procedures in § 63.1005 if a leak is detected. (ii... leak is detected. (d) Special equipment designations: Unsafe-to-repair—(1) Designation and...

  15. 47 CFR 54.635 - Eligible equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... equipment. (a) Both individual and consortium applicants may receive support for network equipment necessary...) Consortium applicants may also receive support for network equipment necessary to manage, control, or maintain an eligible service or a dedicated health care broadband network. Support for network equipment...

  16. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  17. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  18. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  19. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  20. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  1. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Equipment. 225.130 Section 225.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a...

  2. 21 CFR 225.30 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Equipment. 225.30 Section 225.30 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Construction and Maintenance of Facilities and Equipment § 225.30 Equipment. (a) Equipment which...

  3. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.130 Section 225.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a...

  4. 47 CFR 18.203 - Equipment authorization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Equipment authorization. 18.203 Section 18.203 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INDUSTRIAL, SCIENTIFIC, AND MEDICAL EQUIPMENT Applications and Authorizations § 18.203 Equipment authorization. (a) Consumer ISM equipment, unless...

  5. 46 CFR 108.701 - Sounding equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Sounding equipment. 108.701 Section 108.701 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment 108.701 Sounding equipment. Each self-propelled unit must have...

  6. 14 CFR 91.513 - Emergency equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Emergency equipment. 91.513 Section 91.513... Airplanes and Fractional Ownership Program Aircraft § 91.513 Emergency equipment. (a) No person may operate an airplane unless it is equipped with the emergency equipment listed in this section. (b) Each...

  7. 14 CFR 91.513 - Emergency equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Emergency equipment. 91.513 Section 91.513... Airplanes and Fractional Ownership Program Aircraft § 91.513 Emergency equipment. (a) No person may operate an airplane unless it is equipped with the emergency equipment listed in this section. (b) Each...

  8. 7 CFR 58.626 - Packaging equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Packaging equipment. 58.626 Section 58.626 Agriculture....626 Packaging equipment. Packaging equipment designed to mechanically fill and close single service... Standards for Equipment for Packaging Frozen Desserts and Cottage Cheese. Quality Specifications for...

  9. 7 CFR 58.626 - Packaging equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Packaging equipment. 58.626 Section 58.626 Agriculture....626 Packaging equipment. Packaging equipment designed to mechanically fill and close single service... Standards for Equipment for Packaging Frozen Desserts and Cottage Cheese. Quality Specifications for...

  10. 7 CFR 58.626 - Packaging equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Packaging equipment. 58.626 Section 58.626 Agriculture....626 Packaging equipment. Packaging equipment designed to mechanically fill and close single service... Standards for Equipment for Packaging Frozen Desserts and Cottage Cheese. Quality Specifications for...

  11. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards § 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  12. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards § 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  13. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards § 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  14. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards § 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  15. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards § 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  16. 29 CFR 1926.952 - Mechanical equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Mechanical equipment. 1926.952 Section 1926.952 Labor... Mechanical equipment. (a) General. (1) Visual inspections shall be made of the equipment to determine that it... certified for work on the proper voltage, mechanical equipment shall not be operated closer to any...

  17. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. (a) In showing compliance with § 23.1309(a), (b), and (c) with respect to radio and electronic equipment and their installations, critical environmental conditions...

  18. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. (a) In showing compliance with § 23.1309(a), (b), and (c) with respect to radio and electronic equipment and their installations, critical environmental conditions...

  19. Essentials of Career Interest Assessment. Essentials of Psychological Assessment Series.

    ERIC Educational Resources Information Center

    Prince, Jeffrey P.; Heiser, Lisa J.

    This book is a quick reference source to guide the career professional through the essentials of using the most popular career interest tools. It summarizes important technical aspects of each inventory, and offers step-by-step guidance in the interpretation and use of the various inventories. The chapters are: (1) "Overview"; (2) "Strong Interest…

  20. The doctrinal basis for medical stability operations.

    PubMed

    Baker, Jay B

    2010-01-01

    This article describes possible roles for the military in the health sector during stability operations, which exist primarily when security conditions do not permit the free movement of civilian actors. This article reviews the new U.S. Army Field Manuals (FMs) 3-24, Counterinsurgency and FM 3-07, Stability Operations, in the context of the health sector. Essential tasks in medical stability operations are identified for various logical lines of operation including information operations, civil security, civil control, support to governance, support to economic development, and restoration of essential services. Restoring essential services is addressed in detail including coordination, assessment, actions, and metrics in the health sector. Coordination by the military with other actors in the health sector including host nation medical officials, other United States governmental agencies, international governmental organizations (IGOs), and nongovernment organizations (NGOs) is key to success in medical stability operations. PMID:20108837

  1. Effects of equipment loadings on geosynthetic-lined slope behaviour.

    PubMed

    Park, Hyun I; Lee, Seung R

    2005-06-01

    When combined in the lining and covering of waste-containment facilities, soil and geosynthetic components protect the environment by acting as a hydraulic barrier. Equipment loading may significantly increase the tensile stress induced in geosynthetic components, leading to a potential stability problem. Large equipment loadings may also result in a localized circular slip surface during construction operations. New analytical method based on discrete element modelling is proposed for estimating the distribution of tensile force developed in the individual geosynthetic components of the lining system and for evaluating the safety factor of slope failure due to equipment loading. The analytical results of an example are presented to demonstrate the applicability of the analytical method for the lining system of a waste landfill. The analyses of the example show that equipment loading provide a substantial increase in the tensile forces of the geosynthetic components of a lining system and that the possibility of shallow failure due to equipment loading increases as the slope becomes steeper. This method is a useful tool for analysing the lining system of waste landfills with complex lining components. PMID:15988943

  2. Cultural transmission of social essentialism

    PubMed Central

    Rhodes, Marjorie; Leslie, Sarah-Jane; Tworek, Christina M.

    2012-01-01

    Social essentialism entails the belief that certain social categories (e.g., gender, race) mark fundamentally distinct kinds of people. Essentialist beliefs have pernicious consequences, supporting social stereotyping and contributing to prejudice. How does social essentialism develop? In the studies reported here, we tested the hypothesis that generic language facilitates the cultural transmission of social essentialism. Two studies found that hearing generic language about a novel social category diverse for race, ethnicity, age, and sex led 4-y-olds and adults to develop essentialist beliefs about that social category. A third study documented that experimentally inducing parents to hold essentialist beliefs about a novel social category led them to produce more generic language when discussing the category with their children. Thus, generic language facilitates the transmission of essentialist beliefs about social categories from parents to children. PMID:22869722

  3. Stability Tunnel

    NASA Technical Reports Server (NTRS)

    1943-01-01

    Engineers operate the controls of the Stability Tunnel: Plans for a new tunnel to study stability problems began in the late thirties. The Stability Tunnel was authorized in 1939 and began operations in June 1941. The installation was completed in December that year with the completion of a new 10,000 Horsepower Diesel-electric generating plant. It was a single return, closed jet tunnel with a 6-foot square test section. The tunnel was disassembled and shipped to Virginia Polytechnic Institute and State University in 1958. The tunnel had two separate test sections: one for curved flow, the other for rolling flow. 'The facility...simulates the motion of the aircraft in curved or rolling flight. This is done by actually curving or rolling the airstream as it passes over the model and at the same time providing the proper velocity distribution.' (From AIAA-80-0309) >From Alan Pope, Wind-Tunnel Testing: 'The only tunnel directly designed for dynamic stability work is located at the Langley Field branch of the NACA. Its most vital feature is its ability to subject the models to curving air streams that simulate those actually encountered when an airplane rolls, pitches, or yaws. the rotating airstream for simulating roll is produced by a motor-driven paddle just ahead of the test section. Curved air of properly varying velocity for simulating pitch and yaw is produced by a combination of a curved test section and velocity screens. The proper use of this apparatus makes possible the determination of the stability derivatives.' (pp. 13-14)

  4. Analgesic Potential of Essential Oils.

    PubMed

    Sarmento-Neto, José Ferreira; do Nascimento, Lázaro Gomes; Felipe, Cícero Francisco Bezerra; de Sousa, Damião Pergentino

    2015-01-01

    Pain is an unpleasant sensation associated with a wide range of injuries and diseases, and affects approximately 20% of adults in the world. The discovery of new and more effective drugs that can relieve pain is an important research goal in both the pharmaceutical industry and academia. This review describes studies involving antinociceptive activity of essential oils from 31 plant species. Botanical aspects of aromatic plants, mechanisms of action in pain models and chemical composition profiles of the essential oils are discussed. The data obtained in these studies demonstrate the analgesic potential of this group of natural products for therapeutic purposes. PMID:26703556

  5. Tank farms essential drawing plan

    SciTech Connect

    Domnoske-Rauch, L.A.

    1998-08-04

    The purpose of this document is to define criteria for selecting Essential Drawings, Support Drawings, and Controlled Print File (CPF) drawings and documents for facilities that are part of East and West Tank Farms. Also, the drawings and documents that meet the criteria are compiled separate listings. The Essential Drawing list and the Support Drawing list establish a priority for updating technical baseline drawings. The CPF drawings, denoted by an asterisk (*), defined the drawings and documents that Operations is required to maintain per the TWRS Administration Manual. The Routing Boards in Buildings 272-WA and 272-AW are not part of the CPF.

  6. Modeling and simulation of plasma processing equipment

    NASA Astrophysics Data System (ADS)

    Kim, Heon Chang

    Currently plasma processing technology is utilized in a wide range of applications including advanced Integrated Circuit (IC) fabrication. Traditionally, plasma processing equipments have been empirically designed and optimized at great expense of development time and cost. This research proposes the development of a first principle based, multidimensional plasma process simulator with the aim of enhancing the equipment design procedure. The proposed simulator accounts for nonlinear interactions among various plasma chemistry and physics, neutral chemistry and transport, and dust transport phenomena. A three moment modeling approach is employed that shows good predictive capabilities at reasonable computational expense. For numerical efficiency, various versions of explicit and implicit Essentially Non- Oscillatory (ENO) algorithms are employed. For the rapid evaluation of time-periodic steady-state solutions, a feedback control approach is employed. Two dimensional simulation results of capacitively coupled rf plasmas show that ion bombardment uniformity can be improved through simulation based design of the plasma process. Through self-consistent simulations of an rf triode, it is also shown that effects of secondary rf voltage and frequency on ion bombardment energy can be accurately captured. These results prove that scaling relations among important process variables can be identified through the three moment modeling and simulation approach. Through coupling of the plasma model with a neutral chemistry and transport model, spatiotemporal distributions of both charged and uncharged species, including metastables, are predicted for an oxygen plasma. Furthermore, simulation results also verify the existence of a double layer in this electronegative plasma. Through Lagrangian simulation of dust in a plasma reactor, it is shown that small particles are accumulate near the center and the radial sheath boundary depending on their initial positions while large particles are confined near the radial sheath boundary. As a consequence, dust clouds form a ``dome'' shape around the center and a ``ring'' shape near the radial sheath boundary, which is in agreement with experimental observation.

  7. Technology Demonstration Summary, Chemfix Solidification/Stabilization Process, Clackamas, Oregon

    EPA Science Inventory

    ChemfIx's* patented stabilization/solidification technology was demonstrated at the Portable Equipment Salvage Company (PESC) site in Clackamas, Oregon, as part of the Superfund Innovative Technology Evaluation (SITE) program. The Chemfix process is designed to solidify and sta...

  8. Well treating equipment and methods

    SciTech Connect

    Gray, F. R.; Rood, D. D.

    1985-05-28

    Improved equipment and methods for treating wells by processes such as acidizing, gravel packing, and the like, wherein provision is made for removing the excess acid, gravel, and the like, from the well while the work string or pipe, on which the equipment is run into the well, remains connected to the well packer. The pipe string is disconnected from the packer only when it is ready to be removed from the well. Provision is also made for repeating the cleanout operation any number of times, making it possible to perform a series of treating operations during a single trip into the well and removing the excess treating medium after each such treating operation in the series.

  9. Equipment life cycle costs minimised.

    PubMed

    Kuligowski, Sharon

    2004-11-01

    With the cost of energy now a major component of building operating costs, NHS Trust managers increasingly focus on estimating total life cycle costs of equipment such as boiler room and heat, steam and incineration plant. "Life cycle costing" is a broad term and encompasses a wide range of techniques that take into account both initial and future costs as well as the savings of an investment over a period of time. PMID:15575554

  10. LASE equipment mounting deck assembly

    NASA Technical Reports Server (NTRS)

    1991-01-01

    LASE installation graphic illustration; LASE equipment mounting deck assembly graphic illustration. The Lidar Atmospheric Sensing experimental (LASE) instrument, which lies on NASA's high-altitude ER-2 aircraft, has been developed AS A PRECURSOR TO FUTURE NASA Space-Based Global Lidar missions. LASE performed the first ever, fully autonomous, Differential Absorption Lidar (DIAL) vertical profile measurements of water vapor and Lidar measurements of aerosols and provided the highest altitude tropospheric data ever recorded.

  11. Firefighters Integrated Response Equipment System

    NASA Technical Reports Server (NTRS)

    Kaplan, H.; Abeles, F.

    1978-01-01

    The Firefighters Integrated Response Equipment System (Project FIRES) is a joint National Fire Prevention and Control Administration (NFPCA)/National Aeronautics and Space Administration (NASA) program for the development of an 'ultimate' firefighter's protective ensemble. The overall aim of Project FIRES is to improve firefighter protection against hazards, such as heat, flame, smoke, toxic fumes, moisture, impact penetration, and electricity and, at the same time, improve firefighter performance by increasing maneuverability, lowering weight, and improving human engineering design of his protective ensemble.

  12. Interventional Radiology: Equipment and Techniques.

    PubMed

    Scansen, Brian A

    2016-05-01

    The breadth of small animal diseases that can now be treated by a minimally invasive, transcatheter approach continues to expand. Interventional radiology is the field of medicine that affects a therapeutic outcome via minimally invasive catheterization of peripheral blood vessels or body orifices guided by imaging. The intent of this article is to provide an overview of the equipment required for interventional radiology in veterinary medicine with a discussion of technical uses in diseases of dogs and cats. PMID:26916288

  13. Strategy Guideline: HVAC Equipment Sizing

    SciTech Connect

    Burdick, A.

    2012-02-01

    The heating, ventilation, and air conditioning (HVAC) system is arguably the most complex system installed in a house and is a substantial component of the total house energy use. A right-sized HVAC system will provide the desired occupant comfort and will run efficiently. This Strategy Guideline discusses the information needed to initially select the equipment for a properly designed HVAC system. Right-sizing of an HVAC system involves the selection of equipment and the design of the air distribution system to meet the accurate predicted heating and cooling loads of the house. Right-sizing the HVAC system begins with an accurate understanding of the heating and cooling loads on a space; however, a full HVAC design involves more than just the load estimate calculation - the load calculation is the first step of the iterative HVAC design procedure. This guide describes the equipment selection of a split system air conditioner and furnace for an example house in Chicago, IL as well as a heat pump system for an example house in Orlando, Florida. The required heating and cooling load information for the two example houses was developed in the Department of Energy Building America Strategy Guideline: Accurate Heating and Cooling Load Calculations.

  14. Assessment of HYGAS mechanical equipment

    SciTech Connect

    Albrecht, P.R.; Kramberger, F.E.; Recupero, R.M.; Verden, M.L.; Rees, K.

    1980-10-01

    The HYGAS process, which converts coal to substitute natural gas, is being developed by the Institute of Gas Technology (IGT) using an 80 ton per day pilot plant located in Chicago, Illinois. Plant design started in 1967 and testing began in October 1971. Since then, 18,000 tons of both Eastern and Western coal have been gasified. Assessment of the mechanical equipment was made by Mechanical Technology Incorporated (MTI) in collaboration with a DOE on-site representative and a representative from IGT, the operating contractor. Data for the assessment were obtained by reviewing all available maintenance records, by interviewing key personnel from maintenance and operations, and by observing repairs and maintenance procedures where possible. While operating the plant, a variety of equipment problems were addressed, many of which are generic to HYGAS as well as other coal conversion processes. Some problems were solved completely while others were solved to suit the limited needs of the pilot plant. Accordingly, the emphasis of this study is on the degree of success in dealing with equipment failures, the unresolved problems and the implication to future coal conversion plants.

  15. Vibration budget for observatory equipment

    NASA Astrophysics Data System (ADS)

    MacMartin, Douglas G.; Thompson, Hugh

    2015-07-01

    Vibration from equipment mounted on the telescope and in summit support buildings has been a source of performance degradation at existing astronomical observatories, particularly for adaptive optics performance. Rather than relying only on best practices to minimize vibration, we present here a vibration budget that specifies allowable force levels from each source of vibration in the observatory (e.g., pumps, chillers, cryocoolers, etc.). This design tool helps ensure that the total optical performance degradation due to vibration is less than the corresponding error budget allocation and is also useful in design trade-offs, specifying isolation requirements for equipment, and tightening or widening individual equipment vibration specifications as necessary. The vibration budget relies on model-based analysis of the optical consequences that result from forces applied at different locations and frequencies, including both image jitter and primary mirror segment motion. We develop this tool here for the Thirty Meter Telescope but hope that this approach will be broadly useful to other observatories, not only in the design phase, but for verification and operations as well.

  16. Essential English for Micronesian Adults.

    ERIC Educational Resources Information Center

    Conrad, Jo Ann; Reinecke, Hank

    This student workbook is designed to help Micronesian adults learn everyday English. Its ten chapters move from simple one-word picture labeling to more abstract ideas in a spiraled fashion, reiterating the essential elements of the English language in different, more complicated ways. Subjects covered include names for everyday objects and…

  17. Five Essentials of Emergency Planning

    ERIC Educational Resources Information Center

    Barnes, Jill M.

    2011-01-01

    Principals and other administrators seem to be perpetually overworked. There is always something that still needs to be done at the end of the day, and it is easy for disaster planning and preparedness to keep slipping to the bottom of the list. However, disaster preparation is essential, even when planning for the unknown. At some point in every…

  18. Intellectual Workers and Essential Freedoms.

    ERIC Educational Resources Information Center

    Edley, Christopher Jr.

    2000-01-01

    Journalists and college professors deserve certain privileges, including freedom of speech and academic freedom, but they must adapt their work to increasingly diverse populations. They must confront public mistrust, convince people that these freedoms are worthwhile, and protect essential public rights through what they study and teach and to…

  19. Essential Components of Peace Education

    ERIC Educational Resources Information Center

    Johnson, David W.; Johnson, Roger T.

    2005-01-01

    Peace education is a key for establishing a consensual peace and maintaining it over time. There are 5 essential elements in building a lasting peace through education. First, a public education system must be established that has compulsory attendance for all children and youth, integrated so students from previously conflicting groups interact…

  20. Essentials for the Teacher's Toolbox

    ERIC Educational Resources Information Center

    Uhler, Jennifer

    2012-01-01

    Every profession has a set of essential tools for carrying out its work. Airplane mechanics cannot repair engines without sophisticated diagnostics, wrenches, and pliers. Surgeons cannot operate without scalpels and clamps. In contrast, teaching has often been perceived as a profession requiring only students, chalk, and a blackboard in order for…

  1. Essentials of English Language Testing.

    ERIC Educational Resources Information Center

    Kitao, S. Kathleen; Kitao, Kenji

    This book covers essential problems and basic concepts of English language testing. There are 20 chapters in four sections. Section 1, "Background," includes: (1) "Why Teachers Test"; (2) "Some Definitions"; (3) "Validity and Reliability"; and (4) "What You Should Learn about Standardized Tests." Section 2, "Preparing To Write Tests," includes:

  2. Aging assessment of essential HVAC chillers used in nuclear power plants

    SciTech Connect

    Blahnik, D.E.; Camp, T.W.

    1996-09-01

    The Pacific Northwest Laboratory conducted a comprehensive aging assessment of chillers used in the essential safety air-conditioning systems in nuclear power plants (NPPs). The chillers used, and air-conditioning systems served, vary in design from plant to plant. The review of operating experience indicated that chillers experience aging degradation and failures. The primary aging factors of concern for chillers include vibration, excessive temperatures and pressures, thermal cycling, chemical attack, and poor quality cooling water. The evaluation of Licensee Event Reports (LERs) indicated that about 38% of the failures were primarily related to aging, 55% were partially aging related, and 7% of the failures were unassignable. About 25% of the failures were primarily caused by human, design, procedure, and other errors. The large number of errors is probably directly related to the complexity of chillers and their interfacing systems. Nearly all of the LERs were the result of entering plant Technical Specification Limiting Condition for Operation (LCO) that initiated remedial actions like plant shutdown procedures. The trend for chiller-related LERs has stabilized at about 0.13 LERs per plant year since 1988. Carefully following the vendor procedures and monitoring the equipment can help to minimize and/or eliminate most of the premature failures. Recording equipment performance can be useful for trending analysis. Periodic operation for a few hours on a weekly or monthly basis is useful to remove moisture and non-condensable gases that gradually build up inside the chiller. Chiller pressurization kits are available that will help minimize the amount of moisture and air ingress to low-pressure chillers during standby periods. The assessment of service life condition monitoring of chillers indicated there are many simple to sophisticated methods available that can help in chiller surveillance and monitoring.

  3. Impacts of Voltage Sags and Protection Coordination on Sensitive Equipment in Distribution Systems

    NASA Astrophysics Data System (ADS)

    Tien, Le Viet; Tayjasanant, Thavatchai; Yokoyama, Akihiko; Eua-Arporn, Bundhit

    Nowadays, a lot of sensitive electronic equipment is widely used in modern power systems such as power converters and adjustable speed drivers. Voltage sags have gained more interest due to their consequences on the performance of sensitive equipment (SE). Malfunction or failure of the equipment that leads to work or production losses can be caused by voltage sags. As a result, it is essential to have information on equipment sensitivity. If the magnitude and duration of voltage sag exceed the equipment sensitivity threshold, the equipment can malfunction, and such a consequence can affect an entire automatic process, resulting in high economical losses. Reclosers and fuses are the main overcurrent protection devices in distribution systems. Poor coordination may adversely impact on the sensitive equipment. This paper presents a method to analyze impacts of voltage sags and protection coordination on sensitive equipment. A fault position method and mathematical equations describing characteristics of protection devices are used to calculate voltage sags and the protection settings. Voltage tolerance thresholds and protective device characteristics are used to analyze protection and sensitive equipment coordination. Based on the results, new settings for protective devices can be adjusted for sensitive equipment in distribution systems. The Roy Billinton Test System (RBTS) bus 2 is used to analyze impacts of voltage sags and protection coordination.

  4. Essential Medicines in a High Income Country: Essential to Whom?

    PubMed Central

    2015-01-01

    Objective To explore the perspectives of a diverse group of stakeholders engaged in medicines decision making around what constitutes an “essential” medicine, and how the Essential Medicines List (EML) concept functions in a high income country context. Methods In-depth qualitative semi-structured interviews were conducted with 32 Australian stakeholders, recognised as decision makers, leaders or advisors in the area of medicines reimbursement or supply chain management. Participants were recruited from government, pharmaceutical industry, pharmaceutical wholesale/distribution companies, medicines non-profit organisations, academic health disciplines, hospitals, and consumer groups. Perspectives on the definition and application of the EML concept in a high income country context were thematically analysed using grounded theory approach. Findings Stakeholders found it challenging to describe the EML concept in the Australian context because many perceived it was generally used in resource scarce settings. Stakeholders were unable to distinguish whether nationally reimbursed medicines were essential medicines in Australia. Despite frequent generic drug shortages and high prices paid by consumers, many struggled to describe how the EML concept applied to Australia. Instead, broad inclusion of consumer needs, such as rare and high cost medicines, and consumer involvement in the decision making process, has led to expansive lists of nationally subsidised medicines. Therefore, improved communication and coordination is needed around shared interests between stakeholders regarding how medicines are prioritised and guaranteed in the supply chain. Conclusions This study showed that decision-making in Australia around reimbursement of medicines has strayed from the fundamental utilitarian concept of essential medicines. Many stakeholders involved in medicine reimbursement decisions and management of the supply chain did not consider the EML concept in their approach. The wide range of views of what stakeholders considered were essential medicines, challenges whether the EML concept is out-dated or underutilised in high income countries. PMID:26650544

  5. Used energy-related laboratory equipment grant program for institutions of higher learning. Eligible equipment catalog

    SciTech Connect

    Not Available

    1994-07-01

    This is a listing of energy related equipment available through the Energy-Related Laboratory Equipment Grant Program which grants used equipment to institutions of higher education for energy-related research. Information included is an overview of the program, how to apply for a grant of equipment, eligibility requirements, types of equipment available, and the costs for the institution.

  6. Power Product Equipment Technician: Lawn and Garden Equipment. Teacher Edition. Student Version.

    ERIC Educational Resources Information Center

    Hilley, Robert

    This packet contains teacher and student editions for lawn and garden equipment repair and maintenance, intended for the preparation of power product equipment technicians. This publication contains four units: (1) introduction to lawn and garden equipment; (2) light-duty lawn and garden equipment; (3) heavy-duty lawn and garden equipment; and (4)…

  7. JCE Online: Equipment Buyers Guide

    NASA Astrophysics Data System (ADS)

    Holmes, Jon L.

    1999-01-01

    The Equipment Buyers Guide was edited by Jo Rita Jordan. The new Equipment Buyers Guide, bound into the back of this issue, is also a new resource of JCE Internet. This resource provides an online source for the information contained in the printed guide. Placing this information online allows us to regularly update it and to provide live links to the suppliers' WWW sites. The organization of the online version parallels that of the print version. There is an alphabetical list of suppliers and a categorical listing. Links to these lists are provided on every page in the left-hand navigation bar. To quickly find information about a particular supplier, you click Supplier List, click the letter that begins the supplier's name, and scroll through the list to find the supplier. To find which suppliers provide a particular type of instrument or equipment, use the Categories link; click the category of the equipment you are looking for and then click the link to a supplier. You will then be taken to an alphabetical supplier listing page where you can scroll until you find the particular supplier of the item for which you are looking. Once you have found a supplier, the online Equipment Buyers Guide gives you the traditional contact information. But in addition, you also get one-click access to the WWW sites of the suppliers that have them. Depending on the site, you should be able to find information about the items that you seek and may even be able to order the items online! We think that you will find the online version of the Equipment Buyers Guide useful. To make it more useful, please send your suggestions, any errors or omissions you find, and any additional categories to the editor at jjordan@world.std.com The online Equipment Buyers Guide can be found at JCE Online at http://JChemEd.chem.wisc.edu/JCEWWW/Resources/EBG/ JCE Online in '99 JCE Online is your online source of "all things JCE". In order to provide you with an even more useful online resource, JCE Online is undergoing a facelift that will be unveiled at the start of the 1999. In addition to a modified look, we have upgraded the navigation system to provide you with additional links to get you to the information you are looking for more quickly. The new navigation system will retain a menu bar and the left-hand navigation bar. The menu bar across the top of the page will provide quick access to "global" reader service, author, and reviewer information. It will also provide links to a new site map that will give you an overall view of the organization of JCE Online and a new site-wide search engine. The left-hand navigation bar will contain context-sensitive links, sensitive to the specific areas of JCE Online: Journal, Software, Internet, Chem Ed Today. Generally, there will be several more links here than in the current version of JCE Online. We invite you to take a look at the facelift in progress and encourage you to provide suggestions and comments. Please share your suggestions with us, but keep in mind that this is a work in progress and not all links will be working and not all features will be implemented. Email your suggestions to jceonline@chem.wisc.edu. JCE Online 99 can be previewed at http://JChemEd.chem.wisc.edu/Online99/

  8. Protein stability: a crystallographer’s perspective

    PubMed Central

    Deller, Marc C.; Kong, Leopold; Rupp, Bernhard

    2016-01-01

    Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food industries, in addition to being a daily consideration for academic researchers studying proteins. An understanding of protein stability is essential for optimizing the expression, purification, formulation, storage and structural studies of proteins. In this review, discussion will focus on factors affecting protein stability, on a somewhat practical level, particularly from the view of a protein crystallographer. The differences between protein conformational stability and protein compositional stability will be discussed, along with a brief introduction to key methods useful for analyzing protein stability. Finally, tactics for addressing protein-stability issues during protein expression, purification and crystallization will be discussed. PMID:26841758

  9. The EQUIP for Educators Program

    ERIC Educational Resources Information Center

    DiBiase, Ann-Marie; Potter, Granville Bud; Gibbs, John C.

    2011-01-01

    There is a need for proactive support and early intervention to meet the needs of behaviorally at-risk students. There is limited opportunity to intervene with effective results, given that stability of antisocial behavior increases dramatically over time. Moreover, if antisocial behavior patterns are not addressed early on, these children tend to…

  10. A simplified spatial model for BWR stability

    SciTech Connect

    Berman, Y.; Lederer, Y.; Meron, E.

    2012-07-01

    A spatial reduced order model for the study of BWR stability, based on the phenomenological model of March-Leuba et al., is presented. As one dimensional spatial dependence of the neutron flux, fuel temperature and void fraction is introduced, it is possible to describe both global and regional oscillations of the reactor power. Both linear stability analysis and numerical analysis were applied in order to describe the parameters which govern the model stability. The results were found qualitatively similar to past results. Doppler reactivity feedback was found essential for the explanation of the different regions of the flow-power stability map. (authors)

  11. OxygenAbundant and Essential

    NASA Astrophysics Data System (ADS)

    Quinsey, Carolyn S.

    2003-10-01

    Oxygen is colorless, odorless, tasteless, aggressive, necessary for human life, and provides protection from the sun; it is the most abundant element in Earth's crust and makes up approximately two-thirds of the human body by mass. This essential element was the focus of Oxygen, a public symposium held at the University of WisconsinMadison. The symposium included eight presentations on topics related to oxygen; those presentations are synopsized in this article.

  12. HAND TRUCK FOR HANDLING EQUIPMENT

    DOEpatents

    King, D.W.

    1959-02-24

    A truck is described for the handling of large and relatively heavy pieces of equipment and particularly for the handling of ion source units for use in calutrons. The truck includes a chassis and a frame pivoted to the chassis so as to be operable to swing in the manner of a boom. The frame has spaced members so arranged that the device to be handled can be suspended between or passed between these spaced members and also rotated with respect to the frame when the device is secured to the spaced members.

  13. General aviation avionics equipment maintenance

    NASA Technical Reports Server (NTRS)

    Parker, C. D.; Tommerdahl, J. B.

    1978-01-01

    Maintenance of general aviation avionics equipment was investigated with emphasis on single engine and light twin engine general aviation aircraft. Factors considered include the regulatory agencies, avionics manufacturers, avionics repair stations, the statistical character of the general aviation community, and owners and operators. The maintenance, environment, and performance, repair costs, and reliability of avionics were defined. It is concluded that a significant economic stratification is reflected in the maintenance problems encountered, that careful attention to installations and use practices can have a very positive impact on maintenance problems, and that new technologies and a general growth in general aviation will impact maintenance.

  14. Fire suppression and detection equipment

    SciTech Connect

    E.E. Bates

    2006-01-15

    Inspection and testing guidelines go beyond the 'Code of Federal Regulation'. Title 30 of the US Code of Federal Regulations (30 CFR) contains requirements and references to national standards for inspection, testing and maintenance of fire suppression and detection equipment for mine operators. However, federal requirements have not kept pace with national standards and best practices. The article lists National Fire Protection (NFPA) standards that are referenced by the US Mine Safety and Health Administration (MSHA) in 30 CFR. It then discusses other NFPA Standards excluded from 30 CFR and explains the NFPA standard development process. 2 refs., 3 tabs., 5 photos.

  15. Interface standards for computer equipment

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The ability to configure data systems using modules provided by independent manufacturers is complicated by the wide range of electrical, mechanical, and functional characteristics exhibited within the equipment provided by different manufacturers of computers, peripherals, and terminal devices. A number of international organizations were and still are involved in the creation of standards that enable devices to be interconnected with minimal difficulty, usually involving only a cable or data bus connection that is defined by the standard. The elements covered by an interface standard are covered and the most prominent interface standards presently in use are identified and described.

  16. Photographic Equipment Test System (PETS)

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The Photographic Equipment Test System is presented. The device is a mobile optical system designed for evaluating performance of various sensors in a laboratory, in a vacuum chamber or on a flight line. The carriage is designed to allow elevation as well as azimuth control of the direction of the light from the collimator. The pneumatic tires provide an effective vibration isolation system. A target/illumination system is mounted on a motor driven linear slide, and focusing and exposure control can be operated remotely from the small electronics control console.

  17. Olfactory perceptual stability and discrimination.

    PubMed

    Barnes, Dylan C; Hofacer, Rylon D; Zaman, Ashiq R; Rennaker, Robert L; Wilson, Donald A

    2008-12-01

    No two roses smell exactly alike, but our brain accurately bundles these variations into a single percept 'rose'. We found that ensembles of rat olfactory bulb neurons decorrelate complex mixtures that vary by as little as a single missing component, whereas olfactory (piriform) cortical neural ensembles perform pattern completion in response to an absent component, essentially filling in the missing information and allowing perceptual stability. This piriform cortical ensemble activity predicts olfactory perception. PMID:18978781

  18. Large-scale preparation of clove essential oil and eugenol-loaded liposomes using a membrane contactor and a pilot plant.

    PubMed

    Sebaaly, Carine; Greige-Gerges, Hélène; Agusti, Géraldine; Fessi, Hatem; Charcosset, Catherine

    2016-06-01

    Based on our previous study where optimal conditions were defined to encapsulate clove essential oil (CEO) into liposomes at laboratory scale, we scaled-up the preparation of CEO and eugenol (Eug)-loaded liposomes using a membrane contactor (600 mL) and a pilot plant (3 L) based on the principle of ethanol injection method, both equipped with a Shirasu Porous Glass membrane for injection of the organic phase into the aqueous phase. Homogenous, stable, nanometric-sized and multilamellar liposomes with high phospholipid, Eug loading rates and encapsulation efficiency of CEO components were obtained. Saturation of phospholipids and drug concentration in the organic phase may control the liposome stability. Liposomes loaded with other hydrophobic volatile compounds could be prepared at large scale using the ethanol injection method and a membrane for injection. PMID:26099849

  19. 33 CFR 183.330 - Stability test.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Stability test. 183.330 Section 183.330 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY BOATS AND ASSOCIATED EQUIPMENT Flotation Requirements for Outboard Boats Rated for Engines of 2 Horsepower or Less Tests §...

  20. 33 CFR 183.230 - Stability test.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Stability test. 183.230 Section 183.230 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY BOATS AND ASSOCIATED EQUIPMENT Flotation Requirements for Outboard Boats Rated for Engines of More Than 2 Horsepower Tests §...

  1. 46 CFR 153.190 - Stability requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Stability requirements. 153.190 Section 153.190 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment General...

  2. System Design Description PFP Thermal Stabilization

    SciTech Connect

    RISENMAY, H.R.

    2000-04-25

    The purpose of this document is to provide a system design description (SDD) and design basis for the Plutonium Finishing Plant (PFP) Thermal Stabilization project. The chief objective of the SDD is to document the Structures, Systems, and Components (SSCs) that establish and maintain the facility Safety Envelope necessary for normal safe operation of the facility; as identified in the FSAR, the OSRs, and Safety Assessment Documents (SADs). This safety equipment documentation should satisfy guidelines for the SDD given in WHC-SD-CP-TI-18 1, Criteria for Identification and Control of Equipment Necessary for Preservation of the Safety Envelope and Safe Operation of PFP. The basis for operational, alarm response, maintenance, and surveillance procedures are also identified and justified in this document. This document and its appendices address the following elements of the PFP Thermal Stabilization project: Functional and design requirements; Design description; Safety Envelope Analysis; Safety Equipment Class; and Operational, maintenance and surveillance procedures.

  3. Electrical Ground Support Equipment Fabrication, Specification for

    NASA Technical Reports Server (NTRS)

    Denson, Erik C.

    2014-01-01

    This document specifies parts, materials, and processes used in the fabrication, maintenance, repair, and procurement of electrical and electronic control and monitoring equipment associated with ground support equipment (GSE) at the Kennedy Space Center (KSC).

  4. 41 CFR 105-72.404 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... NON-PROFIT ORGANIZATIONS 72.40-Post-Award Requirements/Property Standards § 105-72.404 Equipment. (a... the equipment. (ii) Manufacturer's serial number, model number, Federal stock number, national...

  5. 40 CFR 30.34 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 30.34 Equipment. (a) Title to... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model...

  6. 24 CFR 84.34 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 84.34 Equipment. (a) Title to... the equipment. (ii) Manufacturer's serial number, model number, Federal stock number, national...

  7. 50 CFR 260.102 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... chemical action or physical contact. Such equipment shall be kept in good repair and sanitary condition... and effective bactericidal treatment. Insofar as is practicable, all such equipment shall be made of... with Good Manufacturing Practice Regulations, 21 CFR part 128....

  8. 38 CFR 21.216 - Special equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... The major types of special equipment which may be authorized include: (1) Equipment for educational or... aids to closed-circuit TV systems which amplify reading material for veterans with severe...

  9. 38 CFR 21.216 - Special equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... The major types of special equipment which may be authorized include: (1) Equipment for educational or... aids to closed-circuit TV systems which amplify reading material for veterans with severe...

  10. 38 CFR 21.216 - Special equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... The major types of special equipment which may be authorized include: (1) Equipment for educational or... aids to closed-circuit TV systems which amplify reading material for veterans with severe...

  11. Effect of firefighters' personal protective equipment on gait.

    PubMed

    Park, Huiju; Kim, Seonyoung; Morris, Kristen; Moukperian, Melissa; Moon, Youngjin; Stull, Jeffrey

    2015-05-01

    The biomechanical experiment with eight male and four female firefighters demonstrates that the effect of adding essential equipment: turnout ensemble, self-contained breathing apparatus, and boots (leather and rubber boots), significantly restricts foot pronation. This finding is supported by a decrease in anterior-posterior and medial-lateral excursion of center of plantar pressure (COP) trajectory during walking. The accumulation of this equipment decreases COP velocity and increases foot-ground contact time and stride time, indicating increased gait instability. An increase in the flexing resistance of the boots is the major contributor to restricted foot pronation and gait instability as evidenced by the greater decrease in excursion of COP in leather boots (greater flexing resistance) than in rubber boots (lower resistance). The leather boots also shows the greatest increase in foot contact time and stride time. These negative impacts can increase musculoskeletal injuries in unfavorable fire ground environments. PMID:25683530

  12. Liquid-Liquid Extraction Equipment

    SciTech Connect

    Jack D. Law; Terry A. Todd

    2008-12-01

    Solvent extraction processing has demonstrated the ability to achieve high decontamination factors for uranium and plutonium while operating at high throughputs. Historical application of solvent extraction contacting equipment implies that for the HA cycle (primary separation of uranium and plutonium from fission products) the equipment of choice is pulse columns. This is likely due to relatively short residence times (as compared to mixer-settlers) and the ability of the columns to tolerate solids in the feed. Savannah River successfully operated the F-Canyon with centrifugal contactors in the HA cycle (which have shorter residence times than columns). All three contactors have been successfully deployed in uranium and plutonium purification cycles. Over the past 20 years, there has been significant development of centrifugal contactor designs and they have become very common for research and development applications. New reprocessing plants are being planned in Russia and China and the United States has done preliminary design studies on future reprocessing plants. The choice of contactors for all of these facilities is yet to be determined.

  13. Carbon Absorber Retrofit Equipment (CARE)

    SciTech Connect

    Klein, Eric

    2015-12-23

    During Project DE-FE0007528, CARE (Carbon Absorber Retrofit Equipment), Neumann Systems Group (NSG) designed, installed and tested a 0.5MW NeuStream® carbon dioxide (CO2) capture system using the patented NeuStream® absorber equipment and concentrated (6 molal) piperazine (PZ) as the solvent at Colorado Springs Utilities’ (CSU’s) Martin Drake pulverized coal (PC) power plant. The 36 month project included design, build and test phases. The 0.5MW NeuStream® CO2 capture system was successfully tested on flue gas from both coal and natural gas combustion sources and was shown to meet project objectives. Ninety percent CO2 removal was achieved with greater than 95% CO2product purity. The absorbers tested support a 90% reduction in absorber volume compared to packed towers and with an absorber parasitic power of less than 1% when configured for operation with a 550MW coal plant. The preliminary techno-economic analysis (TEA) performed by the Energy and Environmental Research Center (EERC) predicted an over-the-fence cost of $25.73/tonne of CO2 captured from a sub-critical PC plant.

  14. Brian Dunlap Examines Experimtal Equipment

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Youngstown, Ohio high school student, W. Brian Dunlap (center), discusses with Dr. Robert Head (right), and Henry Floyd, both of the Marshall Space Flight Center (MSFC), his experiment to be performed aboard the Skylab the following year. His experiment, 'Wave Motion Trough A Liquid in Zero Gravity' used a container attached to the end of a leaf spring which was oscillated at specific rates using two thickness differentiated types of liquids. Dunlap was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. The equipment for the experiments was manufactured at MSFC.

  15. Inexpensive Physical Education Equipment for Children.

    ERIC Educational Resources Information Center

    Werner, Peter H.; Simmons, Richard A.

    This book presents ideas for constructing and utilizing homemade recreational equipment for elementary school children. Each chapter deals with acquisition of materials, construction of equipment, and developmental objectives and activities for using the equipment with children. A chapter called "Save Your Junk" gives instructions on how to make…

  16. 21 CFR 1020.31 - Radiographic equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... equipment. The provisions of this section apply to equipment for radiography, except equipment for... during serial radiography, the operator shall be able to terminate the exposure at any time during an exposure of greater than one-half second. Except during panoramic dental radiography, termination...

  17. 21 CFR 1020.31 - Radiographic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... equipment. The provisions of this section apply to equipment for radiography, except equipment for... during serial radiography, the operator shall be able to terminate the exposure at any time during an exposure of greater than one-half second. Except during panoramic dental radiography, termination...

  18. 29 CFR 1926.600 - Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 8 2012-07-01 2012-07-01 false Equipment. 1926.600 Section 1926.600 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Motor Vehicles, Mechanized Equipment, and Marine Operations § 1926.600 Equipment. (a)...

  19. 21 CFR 866.4500 - Immunoelectrophoresis equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Immunoelectrophoresis equipment. 866.4500 Section 866.4500 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunology Laboratory Equipment and Reagents § 866.4500 Immunoelectrophoresis equipment....

  20. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. Link to an amendment published at 76 FR 75761, December 2, 2011. (a) In showing compliance with § 23.1309(b)(1) and (2) with respect to radio and electronic...

  1. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  2. 47 CFR 78.23 - Equipment tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Equipment tests. 78.23 Section 78.23... SERVICE Applications and Licenses § 78.23 Equipment tests. (a) Following the grant of a CARS license, the... Commission, conduct equipment tests for the purpose of such adjustments and measurements as may be...

  3. 47 CFR 73.1610 - Equipment tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Equipment tests. 73.1610 Section 73.1610... Rules Applicable to All Broadcast Stations § 73.1610 Equipment tests. (a) During the process of..., without further authority from the FCC, conduct equipment tests for the purpose of making such...

  4. 47 CFR 74.13 - Equipment tests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Equipment tests. 74.13 Section 74.13... Services in Part 74 § 74.13 Equipment tests. (a) During the process of construction of any class of radio... equipment tests for the purpose of such adjustments and measurements as may be necessary to...

  5. 47 CFR 78.23 - Equipment tests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Equipment tests. 78.23 Section 78.23... SERVICE Applications and Licenses § 78.23 Equipment tests. (a) Following the grant of a CARS license, the... Commission, conduct equipment tests for the purpose of such adjustments and measurements as may be...

  6. 47 CFR 73.1610 - Equipment tests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Equipment tests. 73.1610 Section 73.1610... Rules Applicable to All Broadcast Stations § 73.1610 Equipment tests. (a) During the process of..., without further authority from the FCC, conduct equipment tests for the purpose of making such...

  7. 47 CFR 74.13 - Equipment tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Equipment tests. 74.13 Section 74.13... Services in Part 74 § 74.13 Equipment tests. (a) During the process of construction of any class of radio... equipment tests for the purpose of such adjustments and measurements as may be necessary to...

  8. Proceedings: Substation Equipment Diagnostics Conference VIII

    SciTech Connect

    2000-06-01

    Advanced monitoring and diagnostic sensors and systems are needed to provide reliable and accurate information for determining the condition of major transmission substation equipment. The eighth EPRI Substation Equipment Diagnostics Conference highlighted the work of researchers, universities, manufacturers, and utilities in producing advanced monitoring and diagnostic equipment for substations.

  9. Proceedings: Substation Equipment Diagnostics Conference IX

    SciTech Connect

    2001-09-01

    Advanced monitoring and diagnostic sensors and systems are needed to provide reliable and accurate information for determining the condition of major transmission substation equipment. The ninth EPRI Substation Equipment Diagnostics Conference highlighted the work of researchers, universities, manufacturers, and utilities in producing advanced monitoring and diagnostic equipment for substations.

  10. Proceedings: Tenth EPRI Substation Equipment Diagnostics Conference

    SciTech Connect

    2002-06-01

    Advanced monitoring and diagnostic sensors and systems are needed to provide reliable and accurate information for determining the condition of major transmission substation equipment. The tenth EPRI Substation Equipment Diagnostics Conference highlighted the work of researchers, universities, manufacturers, and utilities in producing advanced monitoring and diagnostic equipment for substations.

  11. 30 CFR 77.1914 - Electrical equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Electrical equipment. 77.1914 Section 77.1914... Shaft Sinking § 77.1914 Electrical equipment. (a) Electric equipment employed below the collar of a.... (b) The insulation of all electric conductors employed below the collar of any slope or shaft...

  12. 30 CFR 77.1914 - Electrical equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Electrical equipment. 77.1914 Section 77.1914... Shaft Sinking § 77.1914 Electrical equipment. (a) Electric equipment employed below the collar of a.... (b) The insulation of all electric conductors employed below the collar of any slope or shaft...

  13. 30 CFR 77.1914 - Electrical equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Electrical equipment. 77.1914 Section 77.1914... Shaft Sinking § 77.1914 Electrical equipment. (a) Electric equipment employed below the collar of a.... (b) The insulation of all electric conductors employed below the collar of any slope or shaft...

  14. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  15. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  16. 32 CFR 32.34 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Equipment. 32.34 Section 32.34 National Defense... ORGANIZATIONS Post-Award Requirements Property Standards § 32.34 Equipment. (a) Title to equipment acquired by a... with § 32.33(b)(3), note that this identification must occur by the time of award, or title to...

  17. 29 CFR 1926.600 - Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 8 2013-07-01 2013-07-01 false Equipment. 1926.600 Section 1926.600 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Motor Vehicles, Mechanized Equipment, and Marine Operations § 1926.600 Equipment. (a)...

  18. 14 CFR 121.605 - Airplane equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Airplane equipment. 121.605 Section 121.605..., FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.605 Airplane equipment. No person may dispatch or release an airplane unless it is airworthy and is equipped as prescribed in §...

  19. 14 CFR 121.605 - Airplane equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airplane equipment. 121.605 Section 121.605..., FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.605 Airplane equipment. No person may dispatch or release an airplane unless it is airworthy and is equipped as prescribed in §...

  20. 27 CFR 19.75 - Major equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... OF THE TREASURY ALCOHOL DISTILLED SPIRITS PLANTS Registration of a Distilled Spirits Plant and Obtaining a Permit Requirements for Registering A Plant § 19.75 Major equipment. As required by § 19.73(a)(9), the application for registration must include a list of the major plant equipment. If the equipment...

  1. 27 CFR 19.75 - Major equipment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Registration of a Distilled Spirits Plant and Obtaining a Permit Requirements for Registering A Plant § 19.75 Major equipment. As required by § 19.73(a)(9), the application for registration must include a list of the major plant equipment. If the equipment...

  2. 27 CFR 19.75 - Major equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Registration of a Distilled Spirits Plant and Obtaining a Permit Requirements for Registering A Plant § 19.75 Major equipment. As required by § 19.73(a)(9), the application for registration must include a list of the major plant equipment. If the equipment...

  3. 27 CFR 19.75 - Major equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... OF THE TREASURY ALCOHOL DISTILLED SPIRITS PLANTS Registration of a Distilled Spirits Plant and Obtaining a Permit Requirements for Registering A Plant § 19.75 Major equipment. As required by § 19.73(a)(9), the application for registration must include a list of the major plant equipment. If the equipment...

  4. 10 CFR 600.134 - Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model number...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate...

  5. 40 CFR 30.34 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model number...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate...

  6. 22 CFR 145.34 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... include the following information. (i) A description of the equipment. (ii) Manufacturer's serial number... Federal Government. (v) Acquisition date (or date received, if the equipment was furnished by the Federal...) Location and condition of the equipment and the date the information was reported. (viii) Unit...

  7. 10 CFR 600.134 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model number...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate...

  8. 40 CFR 30.34 - Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model number...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate...

  9. 40 CFR 30.34 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model number...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate...

  10. 22 CFR 145.34 - Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Federal Government. (v) Acquisition date (or date received, if the equipment was furnished by the Federal...) Location and condition of the equipment and the date the information was reported. (viii) Unit acquisition... include the following information. (i) A description of the equipment. (ii) Manufacturer's serial...

  11. 10 CFR 600.134 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate disposition... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model...

  12. 22 CFR 145.34 - Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Federal Government. (v) Acquisition date (or date received, if the equipment was furnished by the Federal...) Location and condition of the equipment and the date the information was reported. (viii) Unit acquisition... include the following information. (i) A description of the equipment. (ii) Manufacturer's serial...

  13. 40 CFR 30.34 - Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate disposition... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model...

  14. 7 CFR 3019.34 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate disposition... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model...

  15. 7 CFR 3019.34 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate disposition... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model...

  16. 7 CFR 3019.34 - Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate disposition... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model...

  17. 7 CFR 3019.34 - Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Acquisition date (or date received, if the equipment was furnished by the Federal Government) and cost. (vi... equipment and the date the information was reported. (viii) Unit acquisition cost. (ix) Ultimate disposition... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model...

  18. 22 CFR 145.34 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Equipment. 145.34 Section 145.34 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 145.34 Equipment. (a) Title to equipment acquired by...

  19. 33 CFR 175.135 - Existing equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment....

  20. 33 CFR 175.135 - Existing equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment....

  1. 33 CFR 175.135 - Existing equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment....

  2. 33 CFR 175.135 - Existing equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment....

  3. 33 CFR 175.135 - Existing equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment....

  4. Energy data for manure handling equipment

    SciTech Connect

    Safley, L.M.; Nye, J.C.

    1982-07-01

    Approximately 11.4 percent of the energy required to produce livestock is devoted to handling manure. This article presents information on the operating characteristics of most types of manure handling equipment. Equations are developed which describe the power requirements for many of the pieces of equipment discussed. Estimates of energy requirements for given conditions for several pieces of manure handling equipment are presented.

  5. 30 CFR 250.502 - Equipment movement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.502 Equipment movement. The movement of well-completion rigs and related equipment on and off a... master valve prior to moving well-completion rigs and related equipment, unless otherwise approved by...

  6. 30 CFR 250.502 - Equipment movement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.502 Equipment movement. The movement of well-completion rigs and related equipment on and off a... master valve prior to moving well-completion rigs and related equipment, unless otherwise approved by...

  7. 30 CFR 250.502 - Equipment movement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.502 Equipment movement. The movement of well-completion rigs and related equipment on and off a... master valve prior to moving well-completion rigs and related equipment, unless otherwise approved by...

  8. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  9. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  10. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  11. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  12. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  13. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  14. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  15. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  16. 14 CFR 121.335 - Equipment standards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements 121.335 Equipment standards. (a) Reciprocating engine powered airplanes. The oxygen apparatus, the minimum rates of... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Equipment standards. 121.335 Section...

  17. 14 CFR 121.335 - Equipment standards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements 121.335 Equipment standards. (a) Reciprocating engine powered airplanes. The oxygen apparatus, the minimum rates of... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Equipment standards. 121.335 Section...

  18. 50 CFR 260.102 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... with Good Manufacturing Practice Regulations, 21 CFR part 128. ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Equipment. 260.102 Section 260.102... Basis 1 § 260.102 Equipment. All equipment used for receiving, washing, segregating, picking,...

  19. 14 CFR 121.309 - Emergency equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... citations affecting § 121.309, see the List of CFR Sections Affected, which appears in the Finding Aids... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Emergency equipment. 121.309 Section 121... Emergency equipment. (a) General: No person may operate an airplane unless it is equipped with the...

  20. 14 CFR 121.309 - Emergency equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... citations affecting § 121.309, see the List of CFR Sections Affected, which appears in the Finding Aids... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Emergency equipment. 121.309 Section 121... Emergency equipment. (a) General: No person may operate an airplane unless it is equipped with the...

  1. 14 CFR 121.309 - Emergency equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... citations affecting § 121.309, see the List of CFR Sections Affected, which appears in the Finding Aids... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Emergency equipment. 121.309 Section 121... Emergency equipment. (a) General: No person may operate an airplane unless it is equipped with the...

  2. 30 CFR 77.1914 - Electrical equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Electrical equipment. 77.1914 Section 77.1914... Shaft Sinking § 77.1914 Electrical equipment. (a) Electric equipment employed below the collar of a.... (b) The insulation of all electric conductors employed below the collar of any slope or shaft...

  3. 30 CFR 77.1914 - Electrical equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Electrical equipment. 77.1914 Section 77.1914... Shaft Sinking § 77.1914 Electrical equipment. (a) Electric equipment employed below the collar of a.... (b) The insulation of all electric conductors employed below the collar of any slope or shaft...

  4. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Safety equipment. 27.1561 Section 27.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such...

  5. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Safety equipment. 29.1561 Section 29.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  6. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Safety equipment. 27.1561 Section 27.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such...

  7. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Safety equipment. 25.1561 Section 25.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  8. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Safety equipment. 25.1561 Section 25.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  9. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Safety equipment. 29.1561 Section 29.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  10. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Safety equipment. 27.1561 Section 27.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such...

  11. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety equipment. 25.1561 Section 25.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  12. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Safety equipment. 27.1561 Section 27.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such...

  13. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety equipment. 29.1561 Section 29.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  14. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Safety equipment. 29.1561 Section 29.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  15. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety equipment. 27.1561 Section 27.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such...

  16. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Safety equipment. 29.1561 Section 29.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  17. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Safety equipment. 25.1561 Section 25.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  18. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Safety equipment. 25.1561 Section 25.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  19. Sample-related peripheral equipment at IPNS

    SciTech Connect

    Bohringer, D.E.; Crawford, R.K.

    1985-01-01

    This paper describes samples environment equipment provided by IPNS to visiting users and staff scientists. Of the twelve horizontal neutron beam stations, (ten now operational, two under construction) all use one or more form of such support equipment. An in-house support group devotes a significant fraction of its time to development, calibration, and maintenance of this equipment.

  20. 46 CFR 153.484 - Prewash equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Design and Equipment for Pollution Control § 153.484 Prewash equipment. Unless the ship operator shows that the prewash... § 153.908 (a) and (b), a ship must have the following: (a) For the tanks that carry the NLS, a...

  1. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating § 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  2. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating § 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  3. 46 CFR 28.880 - Hydraulic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Hydraulic equipment. 28.880 Section 28.880 Shipping... INDUSTRY VESSELS Aleutian Trade Act Vessels § 28.880 Hydraulic equipment. (a) Each hydraulic system must be... times the system's maximum operating pressure. (c) Each hydraulic system must be equipped with at...

  4. 46 CFR 28.405 - Hydraulic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Hydraulic equipment. 28.405 Section 28.405 Shipping... Operate With More Than 16 Individuals on Board § 28.405 Hydraulic equipment. (a) Each hydraulic system... than four times the system maximum operating pressure. (c) Each hydraulic system must be equipped...

  5. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  6. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  7. 10 CFR 431.405 - Exported equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Exported equipment. 431.405 Section 431.405 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT General Provisions § 431.405 Exported equipment. Under Sections 330 and 345 of the Act, this...

  8. 10 CFR 431.405 - Exported equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Exported equipment. 431.405 Section 431.405 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT General Provisions § 431.405 Exported equipment. Under Sections 330 and 345 of the Act, this...

  9. 40 CFR 264.32 - Required equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... departments, or State or local emergency response teams; (c) Portable fire extinguishers, fire control...), spill control equipment, and decontamination equipment; and (d) Water at adequate volume and pressure to supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems....

  10. 40 CFR 264.32 - Required equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... departments, or State or local emergency response teams; (c) Portable fire extinguishers, fire control...), spill control equipment, and decontamination equipment; and (d) Water at adequate volume and pressure to supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems....

  11. 40 CFR 264.32 - Required equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... departments, or State or local emergency response teams; (c) Portable fire extinguishers, fire control...), spill control equipment, and decontamination equipment; and (d) Water at adequate volume and pressure to supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems....

  12. Preventive maintenance prioritization index of medical equipment using quality function deployment.

    PubMed

    Saleh, Neven; Sharawi, Amr A; Elwahed, Manal Abd; Petti, Alberto; Puppato, Daniele; Balestra, Gabriella

    2015-05-01

    Preventive maintenance is a core function of clinical engineering, and it is essential to guarantee the correct functioning of the equipment. The management and control of maintenance activities are equally important to perform maintenance. As the variety of medical equipment increases, accordingly the size of maintenance activities increases, the need for better management and control become essential. This paper aims to develop a new model for preventive maintenance priority of medical equipment using quality function deployment as a new concept in maintenance of medical equipment. We developed a three-domain framework model consisting of requirement, function, and concept. The requirement domain is the house of quality matrix. The second domain is the design matrix. Finally, the concept domain generates a prioritization index for preventive maintenance considering the weights of critical criteria. According to the final scores of those criteria, the prioritization action of medical equipment is carried out. Our model proposes five levels of priority for preventive maintenance. The model was tested on 200 pieces of medical equipment belonging to 17 different departments of two hospitals in Piedmont province, Italy. The dataset includes 70 different types of equipment. The results show a high correlation between risk-based criteria and the prioritization list. PMID:25029522

  13. Redefining essential care in lymphoedema.

    PubMed

    Wigg, Jane; Lee, Natalie

    2014-04-01

    The awareness, diagnosis and management of chronic oedema and lymphoedema is improving. The enduring treatment format for the condition has always been regarded as the 'four cornerstones' of care for maintenance therapy in the UK. However, with changes in technology, availability of additional treatments and increased research and studies, this baseline is changing. This article outlines some of the recent changes and advancement in diagnostic tools and new technologies used in diagnosing and managing lymphoedema and chronic oedema. Emerging therapies will be introduced, as will other aspects of care that may now be considered 'essential care' in the management of lymphoedema and chronic oedema. PMID:24704751

  14. Communication: essential strategies for success.

    PubMed

    O'Connor, Mary

    2013-06-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change initiatives. With the goal of presenting practical approaches helpful to nurse leaders advance organizational change, content includes evidence-based projects, tool, and resources that mobilize and sustain organizational change initiatives. In this article, the author discusses strategies for communication for change processes, whether large or small. Intentional planning and development of a communication strategy alongside, not as an afterthought, to change initiatives are essential. PMID:23708499

  15. Essential tremor: symptoms and treatment.

    PubMed

    Wick, Jeannette Y; Zanni, Guido R

    2008-05-01

    Essential tremor (ET), traditionally considered benign, is a serious neurologic condition with life-altering repercussions. Its involuntary, rhythmic oscillations involve alternating, irregular, or simultaneous contractions of agonist and antagonist muscles. It is the most common of the 20 known tremor disorders and often confused with Parkinson's disease. Numerous drugs can aggravate ET, and alcohol consumption may alleviate it. Its etiology is unknown. Proven drug treatments are currently limited to propranolol and primidone. This article reviews ET with examples from history to demonstrate points. PMID:18540790

  16. Stabilizing brokerage

    PubMed Central

    Stovel, Katherine; Golub, Benjamin; Milgrom, Eva M. Meyersson

    2011-01-01

    A variety of social and economic arrangements exist to facilitate the exchange of goods, services, and information over gaps in social structure. Each of these arrangements bears some relationship to the idea of brokerage, but this brokerage is rarely like the pure and formal economic intermediation seen in some modern markets. Indeed, for reasons illuminated by existing sociological and economic models, brokerage is a fragile relationship. In this paper, we review the causes of instability in brokerage and identify three social mechanisms that can stabilize fragile brokerage relationships: social isolation, broker capture, and organizational grafting. Each of these mechanisms rests on the emergence or existence of supporting institutions. We suggest that organizational grafting may be the most stable and effective resolution to the tensions inherent in brokerage, but it is also the most institutionally demanding. PMID:22198763

  17. STABILIZED OSCILLATOR

    DOEpatents

    Jessen, P.L.; Price, H.J.

    1958-03-18

    This patent relates to sine-wave generators and in particular describes a generator with a novel feedback circuit resulting in improved frequency stability. The generator comprises two triodes having a common cathode circuit connected to oscillate at a frequency and amplitude at which the loop galn of the circutt ls unity, and another pair of triodes having a common cathode circuit arranged as a conventional amplifier. A signal is conducted from the osciliator through a frequency selective network to the amplifier and fed back to the osciliator. The unique feature of the feedback circuit is the amplifier operates in the nonlinear portion of its tube characteristics thereby providing a relatively constant feedback voltage to the oscillator irrespective of the amplitude of its input signal.

  18. New Perspectives on the Essential Trace Elements.

    ERIC Educational Resources Information Center

    Frieden, Earl

    1985-01-01

    Provides a comprehensive overview of the 19 essential trace elements, examining: the concept of essentiality; evolution of these elements; possible future essential elements; the lanthanides and actinides; how essential trace elements work; the metalloenzymes; the nonmetals; iodine and the thyroid hormones; and antagonism among these elements. (JN)

  19. Proceedings: Substation equipment diagnostics conference 6

    SciTech Connect

    Traub, T.P.

    1998-09-01

    Substation Equipment Diagnostics Conference 6 was held to assemble, assess and communicate information on the latest diagnostic techniques, test devices, and systems for substation equipment. It focused on the latest in diagnostic equipment and techniques being developed by EPRI and others in research programs, as well as the equipment and programs now available and in service by electric utilities. The conference brought together the views of researchers, manufacturers and users. The papers presented were organized under three categories: Transformers, Circuit Breakers and Other Substation Equipment, and Communications/Data Management/System Integration. Exhibit booths were provided for attendees to obtain detailed information about vendor products or services.

  20. Purex: process and equipment performance

    SciTech Connect

    Orth, D.A.

    1986-01-01

    The Purex process is the solvent extraction system that uses tributyl phosphate as the extractant for separating uranium and plutonium from irradiated reactor fuels. Since the first flowsheet was proposed at Oak Ridge National Laboratory in 1950, the process has endured for over 30 years with only minor modifications. The spread of the technology was rapid, and worldwide use or research on Purex-type processes was reported by the time of the 1955 Geneva Conference. The overall performance of the process has been so good that there are no serious contenders for replacing it soon. This paper presents: process description; equipment performance (mixer-settlers, pulse columns, rapid contactors); fission product decontamination; solvent effects (solvent degradation products); and partitioning of uranium and plutonium.