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Sample records for stabilization equipment essential

  1. Characterization equipment essential drawing plan

    SciTech Connect

    WILSON, G.W.

    1999-05-18

    The purpose of this document is to list the Characterization equipment drawings that are classified as Essential Drawings. Essential Drawings: Are those drawings identified by the facility staff as necessary to directly support the safe operation of the facility or equipment (HNF 1997a). The Characterization equipment drawings identified in this report are deemed essential drawings as defined in HNF-PRO-242, Engineering Drawing Requirements (HNF 1997a). These drawings will be prepared, revised, and maintained per HNF-PRO-440, Engineering Document Change Control (HNF 1997b). All other Characterization equipment drawings not identified in this document will be considered Support drawings until the Characterization Equipment Drawing Evaluation Report is completed.

  2. Characterization equipment essential drawing plan

    SciTech Connect

    WILSON, G.W.

    1999-05-14

    The purpose of this document is to list the Characterization equipment drawings that are classified as Essential Drawings and Support Drawings. Essential Drawings: Are those drawings identified by the facility staff as necessary to directly support the safe operation of the facility or equipment (HNF 1997a). Support Drawings: Are those drawings identified by facility staff that further describe the design details of structures, systems, or components shown on essential drawings. (HNF 1997a) The Characterization equipment drawings identified in this report are deemed essential drawings as defined in HNF-PRO-242, Engineering Drawing Requirements (HNF 1997a). These drawings will be prepared, revised, and maintained per HNF-PRO-440, Engineering Document Change Control (HNF 1997b). All other Characterization equipment drawings not identified in this document will be considered General drawings until the Characterization Equipment Drawing Evaluation Report (Wilson 1998) is updated during fiscal year 1999. Trucks 1 and 2 drawings are not included in this revision of the essential drawing list due to uncertainty about future use.

  3. Developing COSHH Essentials: dermal exposure, personal protective equipment and first aid.

    PubMed

    Garrod, A N I; Rajan-Sithamparanadarajah, R

    2003-10-01

    The 'control banding' approach in COSHH Essentials combines the potential for harm with the potential for exposure by inhalation to band measures to control exposure at source, as generic strategies. These are simply adapted to specific tasks and circumstances to produce specific control advice. Where it is not possible or practical to use this control advice, the control bands can suggest adequate respiratory protective equipment using 'protection factors'. Proposals in the paper enable the user to identify the right level of respiratory protective equipment (RPE), and to begin selecting suitable RPE. Selection is made through a formatted questionnaire, enabling the user to give the right facts to the supplier. COSHH Essentials applies mainly to exposure by inhalation. However, skin exposure is very common and uptake via the skin can be an important contributor to body dose. This paper examines the factors concerning skin exposure, and the options for banding the potential for harm to the skin or via the skin. Proposals have then been made for dermal exposure control. Planning for emergencies is an important facet of risk control. Proposals are outlined to band chemical hazards for emergency planning according to a minimum of information, i.e. the danger symbol on a product label. PMID:14530184

  4. THE SITE DEMONSTRATION OF CHEMFIX SOLIDIFICATION/ STABILIZATION PROCESS AT THE PORTABLE EQUIPMENT SALVAGE COMPANY SITE

    EPA Science Inventory

    A demonstration of the GHEMFIX solidification/stabilization process was conducted under the United States Environmental Protection Agency`s (EPA) Superfund Innovative Technology Evaluation (SITE) program. The demonstration was conducted in March 1989, at the Portable Equipment Sa...

  5. Stability of the Martian atmosphere: Is heterogeneous catalysis essential?

    NASA Technical Reports Server (NTRS)

    Atreya, Sushil K.; Gu, Zhen Gang

    1994-01-01

    A comprehensive homogeneous gas phase photochemical model is developed to study the problem of stability of the Martian atmosphere. The one-dimensional model extends from the ground up to 220 km, passing through the homopause at 125 km. The model thus couples the lower (neutral) atmosphere to the ionosphere above which provides significant downward flux of carbon monoxide and oxygen atoms. It is concluded on the basic of currently accepted values for globally and seasonally averaged water vapor abundance, dust opacity and the middle atmospheric eddy mixing coefficient, as well as the relevant laboratory data (particularly the temperature dependence of CO2 absorption cross section and the rate constant for CO+OH reaction), that the rate of re-formation of carbon dioxide exceeds its photolytic destruction rate by about 40%. Furthermore, it is found that this result is virtually independent of the choice of eddy mixing coefficient, unless its value in the middle atmosphere exceeds 10(exp 8) sq cm/sec or is far smaller than 10(exp 5)sq cm/sec, or the dust opacity, unless it exceeds unity, or the water vapor mixing ratio at the surface, unless it is far smaller (less than or = 1 ppm) or far greater (greater than or = 500 ppm) than the average value (approximately 150 ppm). Since none of these extremes represent globally and seasonally averaged conditions on Mars, we propose that the present model requires existence of a mechanism to throttle down the recycling rate of carbon dioxide on Mars. Therefore, it is suggested that a heterogeneous process which provides a sink to the species that participate in the recycling of CO2, i.e., H2O, H2O2, OH, CO or O, in particular, may be necessary to bring about the balance between the CO2 recycling rate and its photolytic destruction rate. Aerosols of dust or ice (pure or doped water or carbon dioxide ice present in the atmosphere of Mars) can provide the appropriate adsorption sites for the above heterogeneous process. Despite our conclusion that some heterogeneous process may be needed, it is important to recognize that one-dimensional models can only provide first-order results which, most likely, represent globally and seasonally averaged conditions. However, it is only after actual temporal, latitudinal and longitudinal variations of relevant atmospheric parameters are included in the model that one can determine fuly whether the problem of atmospheric stabiltiy still continues to persist and whether some heterogeneous process is required to correct it.

  6. SLOPE STABILITY EVALUATION AND EQUIPMENT SETBACK DISTANCES FOR BURIAL GROUND EXCAVATIONS

    SciTech Connect

    MCSHANE DS

    2010-03-25

    After 1970 Transuranic (TRU) and suspect TRU waste was buried in the ground with the intention that at some later date the waste would be retrieved and processed into a configuration for long term storage. To retrieve this waste the soil must be removed (excavated). Sloping the bank of the excavation is the method used to keep the excavation from collapsing and to provide protection for workers retrieving the waste. The purpose of this paper is to document the minimum distance (setback) that equipment must stay from the edge of the excavation to maintain a stable slope. This evaluation examines the equipment setback distance by dividing the equipment into two categories, (1) equipment used for excavation and (2) equipment used for retrieval. The section on excavation equipment will also discuss techniques used for excavation including the process of benching. Calculations 122633-C-004, 'Slope Stability Analysis' (Attachment A), and 300013-C-001, 'Crane Stability Analysis' (Attachment B), have been prepared to support this evaluation. As shown in the calculations the soil has the following properties: Unit weight 110 pounds per cubic foot; and Friction Angle (natural angle of repose) 38{sup o} or 1.28 horizontal to 1 vertical. Setback distances are measured from the top edge of the slope to the wheels/tracks of the vehicles and heavy equipment being utilized. The computer program utilized in the calculation uses the center of the wheel or track load for the analysis and this difference is accounted for in this evaluation.

  7. [Solid adsorption and stability of essential oil from pericarp of Gaultheria yunnaensis (Franch.) Rehd].

    PubMed

    Yang, J; Ma, J; Yang, L; Wu, J; Chen, H

    1998-01-01

    Experiments have been made on the solid adsorption and stability of the essential oil extracted from Gaultheria yunnanensis. The results show that among the chemical constituents of the oil, methyl salicylate accounts for 99.66%. Grain adsorbents of aluminum hydroxide gel have been proved useful in obtaining higher release rates of the oil at required temperatures as well as keeping the oil stable at room temperature. PMID:11243152

  8. Equipment

    NASA Astrophysics Data System (ADS)

    Szumski, Michał

    This chapter describes the most important features of capillary electrophoretic equipment. A presentation of the important developments in high voltage power supplies for chip CE is followed by preparation of fused silica capillaries for use in CE. Detection systems that are used in capillary electrophoresis are widely described. Here, UV-Vis absorbance measurements are discussed including different types of detection cells—also those less popular (u-shaped, Z-shaped, mirror-coated). Fluorescence detection and laser-induced fluorescence detection are the most sensitive detection systems. Several LIF setups, such as collinear, orthogonal, confocal, and sheath-flow cuvette, are presented from the point of view of the sensitivity they can provide. Several electrochemical detectors for CE, such as conductivity, amperometric, and potentiometric, are also shown and their constructions discussed. CE-MS and much less known CE (CEC)-NMR systems are also described. The examples of automation and robotized CE systems together with their potential fields of application are also presented.

  9. DEVELOPMENT OF EQUIPMENT FOR THE RETRIEVAL & STABILIZATION & ENCAPSULATION OF RADIOACTIVE SLUDGE AT THE HANFORD SITE

    SciTech Connect

    ROOSENDAAL, G.D.

    2005-07-05

    This poster presentation describes and illustrates some of the equipment and tools that Fluor Hanford and BNG America have developed and designed to remove, transport, stabilize and encapsulate radioactive sludge from the K Basins at the Hanford nuclear site in Washington State, U.S.A. K Basins were built in the early 1950s to temporarily store irradiated nuclear fuel prior to chemical processing to remove plutonium for nuclear weapons. The sludge is the result of corrosion of these fuel elements and its removal is the final stage before the basin water can be drained and the basins decommissioned. The sludge is hydrogen-generating because of its uranium metal content and account has to be taken also of its heat generating capacity and criticality potential as it is moved from one containment to another. The paper describes all stages of sludge treatment from the use of vacuum wands to suck up the sludge, through consolidating the sludge in temporary underwater containers, transporting it though flexible, temporary pipe systems, acceleration of the corrosion of uranium to reduce hydrogen generation, measuring the fissile content and finally encapsulation in a cement grout. Emphasis is placed on the use of existing, transportable and temporary equipment. This not only saves initial costs but it also reduces the total amount of equipment needed to be disposed of as radioactive waste at the end of the job. The processes, equipment and tools described potentially have a broad applicability to nuclear site decommissioning and cleanup worldwide.

  10. Thermal and oxidative stability of the Ocimum basilicum L. essential oil/?-cyclodextrin supramolecular system

    PubMed Central

    H?d?rug?, Nicoleta G; Costescu, Corina I; David, Ioan; Gruia, Alexandra T

    2014-01-01

    Summary Ocimum basilicum L. essential oil and its ?-cyclodextrin (?-CD) complex have been investigated with respect to their stability against the degradative action of air/oxygen and temperature. This supramolecular system was obtained by a crystallization method in order to achieve the equilibrium of complexeduncomplexed volatile compounds in an ethanol/water solution at 50 C. Both the raw essential oil and its ?-CD complex have been subjected to thermal and oxidative degradation conditions in order to evaluate the protective capacity of ?-CD. The relative concentration of the O. basilicum L. essential oil compounds, as determined by GCMS, varies accordingly with their sensitivity to the thermal and/or oxidative degradation conditions imposed. Furthermore, the relative concentration of the volatile O. basilicum L. compounds found in the ?-CD complex is quite different in comparison with the raw material. An increase of the relative concentration of linalool oxide from 0.3% to 1.1%, in addition to many sesquiterpene oxides, has been observed. ?-CD complexation of the O. basilicum essential oil modifies the relative concentration of the encapsulated volatile compounds. Thus, linalool was better encapsulated in ?-CD, while methylchavicol (estragole) was encapsulated in ?-CD at a concentration close to that of the raw essential oil. Higher relative concentrations from the degradation of the oxygenated compounds such as linalool oxide and aromadendren oxide were determined in the raw O. basilicum L. essential oil in comparison with the corresponding ?-CD complex. For the first time, the protective capability of natural ?-CD for labile basil essential oil compounds has been demonstrated. PMID:25550747

  11. YsxC, an essential protein in Staphylococcus aureus crucial for ribosome assembly/stability

    PubMed Central

    2009-01-01

    Background Bacterial growth and division requires a core set of essential proteins, several of which are still of unknown function. They are also attractive targets for the development of new antibiotics. YsxC is a member of a family of GTPases highly conserved across eubacteria with a possible ribosome associated function. Results Here, we demonstrate by the creation of a conditional lethal mutant that ysxC is apparently essential for growth in S. aureus. To begin to elucidate YsxC function, a translational fusion of YsxC to the CBP-ProteinA tag in the staphylococcal chromosome was made, enabling Tandem Affinity Purification (TAP) of YsxC-interacting partners. These included the ribosomal proteins S2, S10 and L17, as well as the ?' subunit of the RNA polymerase. YsxC was then shown to copurify with ribosomes as an accessory protein specifically localizing to the 50 S subunit. YsxC depletion led to a decrease in the presence of mature ribosomes, indicating a role in ribosome assembly and/or stability in S. aureus. Conclusions In this study we demonstrate that YsxC of S. aureus localizes to the ribosomes, is crucial for ribosomal stability and is apparently essential for the life of S. aureus. PMID:20021644

  12. Sde2: A novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe

    SciTech Connect

    Sugioka-Sugiyama, Rie; Initiative for the Promotion of Young Scientists' Independent Research, University of Tsukuba, Tsukuba, Ibaraki 305-8577 ; Sugiyama, Tomoyasu; Initiative for the Promotion of Young Scientists' Independent Research, University of Tsukuba, Tsukuba, Ibaraki 305-8577; Precursory Research for Embryonic Science and Technology , Japan Science and Technology Agency , Kawaguchi, Saitama 332-0012

    2011-03-18

    Research highlights: {yields} Sde2 is essential for telomere silencing. {yields} Sde2 is involved in the maintenance of genomic stability. {yields} Sde2 promotes the recruitment of SHREC, a histone deacetylase complex, to telomeres. -- Abstract: Telomeres, specialized domains assembled at the ends of linear chromosomes, are essential for genomic stability in eukaryotes. The formation and maintenance of telomeres are governed by numerous factors such as telomeric repeats, telomere-binding proteins, heterochromatin proteins, and telomerase. Here, we report Sde2, a novel nuclear protein essential for telomeric silencing and genomic stability in the fission yeast Schizosaccharomyces pombe. A deficiency in sde2 results in the derepression of the ura4{sup +} gene inserted near telomeric repeats, and the noncoding transcripts from telomeric regions accumulate in sde2{Delta} cells. The loss of Sde2 function compromises transcriptional silencing at telomeres, and this silencing defect is accompanied by increased levels of acetylated histone H3K14 and RNA polymerase II occupancy at telomeres as well as reduced recruitment of the SNF2 ATPase/histone deacetylase-containing complex SHREC to telomeres. Deletion of sde2 also leads to a higher frequency of mitotic minichromosome loss, and sde2{Delta} cells often form asci that contain spores in abnormal numbers, shapes, or both. In addition, sde2{Delta} cells are highly sensitive to several stresses, including high/low temperatures, bleomycin, which induces DNA damage, and thiabendazole, a microtubule-destabilizing agent. Furthermore, Sde2 genetically interacts with the telomere regulators Taz1, Pof3, and Ccq1. These findings demonstrate that Sde2 cooperates with other telomere regulators to maintain functional telomeres, thereby preventing genomic instability.

  13. Stability of nonfouling electroless nickel-polytetrafluoroethylene coatings after exposure to commercial dairy equipment sanitizers.

    PubMed

    Huang, Kang; Goddard, Julie M

    2015-09-01

    Application of nonfouling coatings on thermal processing equipment can improve operational efficiency. However, to enable effective commercial translation, a need exists for more comprehensive studies on the stability of nonfouling coatings after exposure to different sanitizers. In the current study, the influence of different commercial dairy equipment sanitizers on the nonfouling properties of stainless steel modified with electroless Ni-polytetrafluoroethylene (PTFE) coatings was determined. Surface properties, such as dynamic contact angle, surface energy, surface morphology, and elemental composition, were measured before and after the coupons were exposed to the sanitizers for 168 cleaning cycles. The fouling behavior of Ni-PTFE-modified stainless steel coupons after exposure was also evaluated by processing raw milk on a self-fabricated benchtop-scale plate heat exchanger. The results indicated that peroxide sanitizer had only minor effect on the Ni-PTFE-modified stainless steel surface, whereas chlorine- and iodine-based sanitizers influenced the surface properties drastically. The coupons after 168 cycles of exposure to peroxide sanitizer accumulated the least amount of fouling material (4.440.24mg/cm(2)) compared with the coupons exposed to the other 3 sanitizers. These observations indicated that the Ni-PTFE nonfouling coating retained antifouling properties after 168 cycles of exposure to peroxide-based sanitizer, supporting their potential application as nonfouling coatings for stainless steel dairy processing equipment. PMID:26142857

  14. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability

    PubMed Central

    Xu, Dongyi; Guo, Rong; Sobeck, Alexandra; Bachrati, Csanad Z.; Yang, Jay; Enomoto, Takemi; Brown, Grant W.; Hoatlin, Maureen E.; Hickson, Ian D.; Wang, Weidong

    2008-01-01

    BLM, the helicase mutated in Bloom syndrome, associates with topoisomerase 3?, RMI1 (RecQ-mediated genome instability), and RPA, to form a complex essential for the maintenance of genome stability. Here we report a novel component of the BLM complex, RMI2, which interacts with RMI1 through two oligonucleotide-binding (OB)-fold domains similar to those in RPA. The resulting complex, named RMI, differs from RPA in that it lacks obvious DNA-binding activity. Nevertheless, RMI stimulates the dissolution of a homologous recombination intermediate in vitro and is essential for the stability, localization, and function of the BLM complex in vivo. Notably, inactivation of RMI2 in chicken DT40 cells results in an increased level of sister chromatid exchange (SCE)the hallmark feature of Bloom syndrome cells. Epistasis analysis revealed that RMI2 and BLM suppress SCE within the same pathway. A point mutation in the OB domain of RMI2 disrupts the association between BLM and the rest of the complex, and abrogates the ability of RMI2 to suppress elevated SCE. Our data suggest that multi-OB-fold complexes mediate two modes of BLM action: via RPA-mediated proteinDNA interaction, and via RMI-mediated proteinprotein interactions. PMID:18923082

  15. Effect of downhole assembly and cutter geometry on stability of drillstrings equipped with polycrystalline diamond compact (PDC) cutters

    SciTech Connect

    Elsayed, M.A.; Dareing, D.W.; Dupuy, C.A.

    1996-11-01

    Stability of drillstrings equipped with PDC cutters depends on many factors such as the design of the drillstring, design of the cutter, and formation type. In this paper, the authors show that the drill pipe plays a minor role in stability in comparison with that of the drill collars. They also show that the number of cutter blades affects the location of the stability pockets, while their spacing affects the size of these pockets. Using this data, a combination of drill collar and cutter design can be used to provide operating speeds resulting in maximum stability of the drillstring.

  16. Essential role of Pin1 in regulation of TRF1 stability and telomere maintenance

    PubMed Central

    Lee, Tae Ho; Tun-Kyi, Adrian; Shi, Rong; Lim, Jormay; Soohoo, Christina; Finn, Greg; Balastik, Martin; Pastorino, Lucia; Wulf, Gerburg; Zhou, Xiao Zhen; Lu, Kun Ping

    2009-01-01

    Telomeres are essential for maintaining cellular proliferative capacity and their loss has been implicated in aging. A key regulator in telomere maintenance is the telomeric protein TRF1, which was also identified as Pin2 in a same screen for Pin1. Pin1 is a unique prolyl isomerase that regulates protein conformation and function after phosphorylation. However, little is known about the role of Pin1 in telomere regulation and the modulation of TRF1 by upstream signals. Here we identify TRF1 as a major conserved substrate for Pin1 during telomere maintenance and aging. Pin1 inhibition renders TRF1 resistant to protein degradation, enhances TRF1 binding on telomeres, and leads to gradual telomere loss in human cells and in mice. Pin1-deficient mice also display widespread premature aging phenotypes within just one generation similar to those in telomerase-deficient mice after 4–5 consecutive generations. Thus, Pin1 is an essential novel regulator of TRF1 stability, telomere maintenance and aging. PMID:19060891

  17. Enhancement of plant essential oils' aqueous solubility and stability using alpha and beta cyclodextrin.

    PubMed

    Samperio, Cristian; Boyer, Renee; Eigel, William N; Holland, Kevin W; McKinney, Julie S; O'Keefe, Sean F; Smith, Richard; Marcy, Joseph E

    2010-12-22

    Sodium benzoate has been shown to produce benzene in combination with ascorbic acid. This has led to research for safe alternatives from plant essential oils and parabens that have shown some antimicrobial activity, but many of these compounds exhibit poor solubility in aqueous solutions. Cyclodextrins can increase the solubility of many compounds. This work aimed to investigate the solubility of 23 plant essential oils and 4 parabens in water and an apple juice medium. Four of these compounds were chosen for their low aqueous solubility to determine if complexing the compound with ?- and ?-cyclodextrin would increase solubility. Three of the complexes were dissolved in an acidified aqueous solution and then studied in glass and polyethylene terephthalate (PET) to determine if storage material would affect the stability. Solubility of the 27 compounds in distilled water ranged from 1.6 mg/L to 2460.6 mg/L and the solubility of 18 of the compounds decreased from 2.5 to 84.7% in apple juice medium (pH = 3.4, 12-13 Brix). Complexation with cyclodextrin dramatically increased the solubility of the compounds, up to 10-fold. Packaging material had no effect on concentration of compounds present over 7 days. Cyclodextrins were able to increase solubility of these compounds to more suitable concentrations, and may lead to viable natural alternatives to sodium benzoate. PMID:21077682

  18. ?-tubulin is essential in Tetrahymena thermophila for the assembly and stability of basal bodies.

    PubMed

    Ross, Ian; Clarissa, Christina; Giddings, Thomas H; Winey, Mark

    2013-08-01

    Basal bodies and centrioles are conserved microtubule-based organelles the improper assembly of which leads to a number of diseases, including ciliopathies and cancer. Tubulin family members are conserved components of these structures that are integral to their proper formation and function. We have identified the ?-tubulin gene in Tetrahymena thermophila and detected the protein, through fluorescence of a tagged allele, to basal bodies. Immunoelectron microscopy has shown that ?-tubulin localizes primarily to the core microtubule scaffold. A complete genomic knockout of ?-tubulin has revealed that it is an essential gene required for the assembly and maintenance of the triplet microtubule blades of basal bodies. We have conducted site-directed mutagenesis of the ?-tubulin gene and shown that residues within the nucleotide-binding domain, longitudinal interacting domains, and C-terminal tail are required for proper function. A single amino acid change of Thr150, a conserved residue in the nucleotide-binding domain, to Val is a conditional mutation that results in defects in the spatial and temporal assembly of basal bodies as well as their stability. We have genetically separated functions for the domains of ?-tubulin and identified a novel role for the nucleotide-binding domain in the regulation of basal body assembly and stability. PMID:23704354

  19. Hybrid nanomaterial for stabilizing the antibiofilm activity of Eugenia carryophyllata essential oil.

    PubMed

    Grumezescu, Alexandru Mihai; Chifiriuc, Mariana Carmen; Saviuc, Crina; Grumezescu, Valentina; Hristu, Radu; Mihaiescu, Dan Eduard; Stanciu, George A; Andronescu, Ecaterina

    2012-12-01

    The aim of the present study was to demonstrate that Fe(3)O(4)/oleic acid core/shell nanostructures could be used as systems for stabilizing the Eugenia carryophyllata essential oil (EO) on catheter surface pellicles, in order to improve their resistance to fungal colonization. EO microwave assisted extraction was performed in a Neo-Clevenger (related) device and its chemical composition was settled by GC-MS analysis. Fe(3)O(4)/oleic acid-core/shell nanoparticles (NP) were obtained by a precipitation method under microwave condition. High resolution transmission electron microscopy (HR-TEM) was used as a primary characterization method. The NPs were processed to achieve a core/shell/EO coated-shell nanosystem further used for coating the inner surface of central venous catheter samples. The tested fungal strains have been recently isolated from different clinical specimens. The biofilm architecture was assessed by confocal laser scanning microscopy (CLSM). Our results claim the usage of hybrid nanomaterial (core/shell/coated-shell) for the stabilization of E. carryophyllata EO, which prevented or inhibited the fungal biofilm development on the functionalized catheter, highlighting the opportunity of using these nanosystems to obtain improved, anti-biofilm coatings for biomedical applications. PMID:22949098

  20. Stabilization of sunflower oil with Carum copticum Benth & Hook essential oil.

    PubMed

    Hashemi, Mohammad Bagher; Niakousari, Mehrdad; Saharkhiz, Mohammad Jamal; Eskandari, Mohammad Hadi

    2014-01-01

    In this study, application of various concentrations (0.025%, 0.05% and 0.075%) of Carum copticum essential oil (EO) were examined on oxidative stability of sunflower oil and there were compared to Butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) during storage at 37 and 47C. The main compounds of EO were identified as thymol (50.07%), ?- terpinene (23.92%) and p-cymene (22.9%). Peroxide value (PV), anisidine value (AnV) and thiobarbituric acid (TBA) value measurement in sunflower oil showed that all concentrations of EO had antioxidant effect in comparison to BHA and BHT. Samples added with EO at 0.075% were the most stable during storage at both temperatures (P?stabilization factor (F) and antioxidant power (AOP) determination confirmed efficacy of this EO as antioxidant in sunflower oil. EO also was able to reduce the stable free radical 2, 2-diphenyl-1-picrylhydrazyl (DPPH) with a 50% inhibition concentration (IC50) of 20.3??0.9?g/mL. Therefore, the results indicate that EO could be used as a natural antioxidant in food lipids. PMID:24426060

  1. Evaluation of thermal-oxidative stability and antiglioma activity of Zanthoxylum tingoassuiba essential oil entrapped into multi- and unilamellar liposomes.

    PubMed

    Detoni, Cassia B; de Oliveira, Diêgo Madureira; Santo, Islane E; Pedro, André São; El-Bacha, Ramon; da Silva Velozo, Eudes; Ferreira, Domingos; Sarmento, Bruno; de Magalhães Cabral-Albuquerque, Elaine C

    2012-03-01

    Zanthoxylum tinguassuiba essential oil (ZtEO) contains α-bisabolol, a known antiglioma sesquiterpene, among other potentially active substances. Medical applications of this essential oil require advances in the design of distinctive carriers due to its low water solubility and easy degradation by heat, light, and oxygen. The aim of this work was to evaluate enhancement in oxidative stability and the ability to reduce glioblastoma cell viability of ZtEO loaded into liposomes. Multi- and unilamellar vesicles were prepared to carry ZtEO. By using thermal analysis, it was observed that thermal-oxidative stability of the liposomal ZtEO was enhanced, when compared to its free form. Liposomal ZtEO also presented significant apoptotic-inducing activity for glioma cells. These results show that liposomal systems carrying ZtEO may be a potential alternative for gliobastoma treatment. PMID:21548711

  2. Coaxial type of self-mixing interferometer equipped with a wavelength stabilizing system

    NASA Astrophysics Data System (ADS)

    Suzuki, Takamasa; Irisawa, Tsutomu; Yokoyama, Kazuhiro; Sasaki, Osami

    2002-06-01

    Because the wavelength of a laser diode (LD) has the temperature-sensitivity, in conventional LD interferometers, a temperature control is required to stabilize the wavelength in long-term measurements. We propose a self-mixing laser diode interferometer that has two coaxial measurement arms. Two interference signals are used for the measurement of displacement and wavelength stabilization in our system. As the wavelength is not stabilized thermostatically, but by adjusting current feedback, compensation is simple and response-time minimal. The feedback controls for displacement measurement and wavelength stabilization were implemented on a time-sharing basis. The devise we propose enables us to conduct long-term measurements of microscopic levels of displacement.

  3. A way for improving the stability of the essential oils in an environmental friendly formulation.

    PubMed

    R?ileanu, M?lina; Todan, Ligia; Voicescu, Mariana; Ciuculescu, Crinu; Maganu, Maria

    2013-08-01

    The essential oils (EOs) possess amazing properties explaining the interest for their applications in many essential domains. They also present the disadvantage of their chemical instability in the presence of air, light, moisture, and high temperatures. The paper focuses on two of the most known and used EOs, lavender and mint, respectively. The idea of the study was to protect them using the encapsulated systems. The originality of the work consists in the combination between the advantages of the molecular encapsulation of the EOs by cyclodextrins (CD) with the advantages offered by the sol-gel process. Original formulations have been processed by entrapping these essential oils in silica matrices obtained from a colloidal silica sol by the aqueous route of the sol-gel method. Another non-toxic ingredient, ?-cyclodextrin, able to form inclusion complexes (ICs) with the essential oils has been used. The characterization methods (chromatography, UV-vis, IR, and NMR spectroscopies) have evidenced the presence of the mentioned inclusion complexes. Due to their formation, which modifies the water solubility of the EOs, the chromatographic analysis was possible using water as solvent, which is a novelty in EOs determinations. Protected from both the cyclodextrin and silica matrix, the essential oils became more resistant versus the effects of the environment factors. Thus, the resulted powders can find applications in domains as agriculture, food industries, cosmetics, pharmaceutical, and medicine. PMID:23706211

  4. A comprehensive review of rollover accidents involving vehicles equipped with Electronic Stability Control (ESC) systems.

    PubMed

    Padmanaban, Jeya; Shields, Leland E; Scheibe, Robert R; Eyges, Vitaly E

    2008-10-01

    This study investigated 478 police accident reports from 9 states to examine and characterize rollover crashes involving ESC-equipped vehicles. The focus was on the sequence of critical events leading to loss of control and rollover, and the interactions between the accident, driver, and environment. Results show that, while ESC is effective in reducing loss of control leading to certain rollover crashes, its effectiveness is diminished in others, particularly when the vehicle departs the roadway or when environmental factors such as slick road conditions or driver factors such as speeding, distraction, fatigue, impairment, or overcorrection are present. PMID:19026219

  5. A Comprehensive Review of Rollover Accidents Involving Vehicles Equipped with Electronic Stability Control (ESC) Systems

    PubMed Central

    Padmanaban, Jeya; Shields, Leland E.; Scheibe, Robert R.; Eyges, Vitaly E.

    2008-01-01

    This study investigated 478 police accident reports from 9 states to examine and characterize rollover crashes involving ESC-equipped vehicles. The focus was on the sequence of critical events leading to loss of control and rollover, and the interactions between the accident, driver, and environment. Results show that, while ESC is effective in reducing loss of control leading to certain rollover crashes, its effectiveness is diminished in others, particularly when the vehicle departs the roadway or when environmental factors such as slick road conditions or driver factors such as speeding, distraction, fatigue, impairment, or overcorrection are present. PMID:19026219

  6. Effects of dietary oregano essential oil and vitamin E on the lipid oxidation stability of cooked chicken breast meat.

    PubMed

    Avila-Ramos, F; Pro-Martnez, A; Sosa-Montes, E; Cuca-Garca, J M; Becerril-Prez, C M; Figueroa-Velasco, J L; Narciso-Gaytn, C

    2012-02-01

    The antioxidant effect of oregano essential oil and vitamin E was evaluated in cooked chicken breast meat. In total, 480 broilers were randomly assigned to 6 treatments and 4 replications. Broilers were raised with a corn-soybean meal diet including either crude soybean oil or acidulated soybean oil soapstock, each supplemented with vitamin E at 10 or 100 mg or oregano essential oil at 100 mg/kg of feed. At 42 d, broilers were slaughtered and their breast meat was prepared into strips (1.5 10 cm) or patties (150 g). Fatty acid composition of the muscle was determined. For lipid oxidation stability, both meat strips and patties were cooked to an internal temperature of 74C and malonaldehyde contents were assessed during 0, 3, 6, and 9 d of storage at 4C. Each storage day had 4 replications per treatment. The meat lipid oxidative stability was estimated by content of malonaldehyde values. Results showed that feed consumption, weight gain, and feed conversion were not affected by the dietary oils or antioxidants, except for the mortality in acidulated soybean oil soapstock with the 10-mg vitamin E treatment. The fatty acid composition of the meat was similar between the 2 diets given the same antioxidant supplement. The oxidation stability of meat lipids in both types of meats showed a significant (P < 0.05) interaction between oils, antioxidants, and storage time. In the crude soybean oil oil diet, the malonaldehyde value in the 10-mg vitamin E treatment was the highest, followed by oregano essential oil, and then the 100-mg vitamin E treatment at 9 d of storage, whereas the value of oregano essential oil in the acidulated soybean oil soapstock diet was the highest, followed by the 10-mg vitamin E, and then the 100-mg vitamin E treatment during the 9 d of storage. In conclusion, the dietary oils and antioxidants used can be included in broiler diets without negative effects on their productivity. The antioxidant effect of vitamin E was higher with a higher supplementation level, regardless of the oil treatment, whereas the antioxidant effect of oregano essential oil was better in crude soybean oil than in the acidulated soybean oil soapstock diet. PMID:22252366

  7. USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.

    PubMed

    Zlatanou, A; Sabbioneda, S; Miller, E S; Greenwalt, A; Aggathanggelou, A; Maurice, M M; Lehmann, A R; Stankovic, T; Reverdy, C; Colland, F; Vaziri, C; Stewart, G S

    2016-02-25

    Rad18 functions at the cross-roads of three different DNA damage response (DDR) pathways involved in protecting stressed replication forks: homologous recombination repair, DNA inter-strand cross-link repair and DNA damage tolerance. Although Rad18 serves to facilitate replication of damaged genomes by promoting translesion synthesis (TLS), this comes at a cost of potentially error-prone lesion bypass. In contrast, loss of Rad18-dependent TLS potentiates the collapse of stalled forks and leads to incomplete genome replication. Given the pivotal nature with which Rad18 governs the fine balance between replication fidelity and genome stability, Rad18 levels and activity have a major impact on genomic integrity. Here, we identify the de-ubiquitylating enzyme USP7 as a critical regulator of Rad18 protein levels. Loss of USP7 destabilizes Rad18 and compromises UV-induced PCNA mono-ubiquitylation and Pol η recruitment to stalled replication forks. USP7-depleted cells also fail to elongate nascent daughter strand DNA following UV irradiation and show reduced DNA damage tolerance. We demonstrate that USP7 associates with Rad18 directly via a consensus USP7-binding motif and can disassemble Rad18-dependent poly-ubiquitin chains both in vitro and in vivo. Taken together, these observations identify USP7 as a novel component of the cellular DDR involved in preserving the genome stability. PMID:25961918

  8. Characterization of polymorph transformations that decrease the stability of tablets containing the WHO essential drug mebendazole.

    PubMed

    Brits, Marius; Liebenberg, Wilna; de Villiers, Melgardt M

    2010-03-01

    This study investigated the influence of moisture and heat on the stability of mebendazole polymorph C in tablets. The polymorphic forms of mebendazole display significant differences in solubility and therapeutic efficacy and form C is preferred clinically due to its optimal bioavailability and reduced toxicity. An accelerated stability study of the polymorphs revealed that the Johnson-Mehl-Avrami-Erofeyev-Kolmogorov (JMAEK) model best described the kinetics of the solid-state transformation of form C to A. Rate constants obtained using this model was used to calculated half-lives and shelf lives of products stored under ICH conditions of 30 degrees C + 65% RH and 40 degrees C + 75% RH. Results showed that form C was converted to the thermodynamic stable, least soluble form A with increased temperatures and moisture, and at constant temperature and relative humidity this transformation was significantly increased when trace amounts of form A was present in the tablets. Four out of the seven products tested contained trace amounts of form A. In some tablets, the transformation to form A was so quick that it reduced the shelf life to less than 1 month. The tablet dissolution of these products was reduced to such an extent that it did not comply with USP and FDA specifications. PMID:19691117

  9. A mammalian NudC-like protein essential for dynein stability and cell viability

    PubMed Central

    Zhou, Tianhua; Zimmerman, Wendy; Liu, Xiaoqi; Erikson, Raymond L.

    2006-01-01

    Cytoplasmic dynein, a minus-end-directed microtubule motor, has been implicated in many fundamental cellular processes; however, little is known regarding the underlying molecular machinery that regulates its stability. In Aspergillus nidulans, nuclear distribution gene C (nudC) has been implicated in the regulation of dynein-mediated nuclear migration. Here, we characterize a previously undescribed mammalian NudC-like protein (NudCL). The expression and phosphorylation of NudCL are increased during mitosis. Depletion of NudCL by RNA interference in HeLa cells inhibits cell growth and induces mitotic arrest with multiple mitotic defects, which subsequently result in cell death. Unexpectedly, the majority of NudCL depletion-induced mitotic defects may result from loss of dynein function; this interpretation is supported by the failure to recruit sufficient γ-tubulin to spindle poles and the mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles during mitosis. Depletion of NudCL also results in the aggregation of dynein intermediate chain throughout the cytoplasm during mitosis. NudCL was shown to bind to the dynein complex, and its depletion induces degradation of dynein intermediate chain, a process suppressed by MG132, a proteasome inhibitor. Taken together, these data suggest a previously undescribed mechanism whereby NudCL appears to influence the stabilization of dynein intermediate chain. PMID:16754861

  10. Operational stability of rubidium and cesium frequency standards. [analysis of equipment performance at NASA tracking stations

    NASA Technical Reports Server (NTRS)

    Lavery, J. E.

    1972-01-01

    In the course of testing various rubidium and cesium frequency standards under operational conditions for use in NASA tracking stations, about 55 unit-years of relative frequency measurements for averaging times from 10 to 10 to the 7th power have been accumulated at Goddard Space Flight Center (GSFC). Statistics on the behavior of rubidium and cesium standards under controlled laboratory conditions have been published, but it was not known to what extent the lesser controlled environments of NASA tracking stations affected the performance of the standards. The purpose of this report is to present estimates of the frequency stability of rubidium and cesium frequency standards under operational conditions based on the data accumulated at GSFC.

  11. Enhancing stability of essential oils by microencapsulation for preservation of button mushroom during postharvest

    PubMed Central

    Alikhani-Koupaei, Majid; Mazlumzadeh, Meisam; Sharifani, Mohamadmehdi; Adibian, Mohamad

    2014-01-01

    Fresh button mushrooms (Agaricus bisporus L.) are sensitive to browning, water loss, and microbial attack. The short shelf-life of mushrooms is an impediment to the distribution and marketing of the fresh product. Essential oils outstand as an alternative to chemical preservatives and their use in foods meets the demands of consumers for natural products. To resolve controlled release of oil and increase in antioxidant and antimicrobial activities, the oil was incorporated into microcapsules. Effects of microcapsulated thyme (Thymus vulgaris L.) and rosemary (Rosmarinus officinalis L.) on quality of fresh button mushroom were compared. Physicochemical qualities were evaluated during 15 days of storage at 4 ± 0.5°C. All treatments prevented product weight loss and decrease in polyphenoloxidase and peroxidase activities during storage. Color and firmness, microbiological analysis, and total phenolic content caused the least change. With use of microencapsulated oils, mushrooms were within acceptable limits during 10 days of storage. Microencapsulated rosemary oil produced the highest beneficial effects and has potential to improve quality of button mushrooms and extend shelf-life. PMID:25473510

  12. Enhancing stability of essential oils by microencapsulation for preservation of button mushroom during postharvest.

    PubMed

    Alikhani-Koupaei, Majid; Mazlumzadeh, Meisam; Sharifani, Mohamadmehdi; Adibian, Mohamad

    2014-09-01

    Fresh button mushrooms (Agaricus bisporus L.) are sensitive to browning, water loss, and microbial attack. The short shelf-life of mushrooms is an impediment to the distribution and marketing of the fresh product. Essential oils outstand as an alternative to chemical preservatives and their use in foods meets the demands of consumers for natural products. To resolve controlled release of oil and increase in antioxidant and antimicrobial activities, the oil was incorporated into microcapsules. Effects of microcapsulated thyme (Thymus vulgaris L.) and rosemary (Rosmarinus officinalis L.) on quality of fresh button mushroom were compared. Physicochemical qualities were evaluated during 15 days of storage at 4 0.5C. All treatments prevented product weight loss and decrease in polyphenoloxidase and peroxidase activities during storage. Color and firmness, microbiological analysis, and total phenolic content caused the least change. With use of microencapsulated oils, mushrooms were within acceptable limits during 10 days of storage. Microencapsulated rosemary oil produced the highest beneficial effects and has potential to improve quality of button mushrooms and extend shelf-life. PMID:25473510

  13. Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth.

    PubMed

    Koo, Yeon; Barry, David M; Xu, Ke; Tanigaki, Keiji; Davis, George E; Mineo, Chieko; Cleaver, Ondine

    2016-04-01

    Cardiovascular function depends on patent, continuous and stable blood vessel formation by endothelial cells (ECs). Blood vessel development initiates by vasculogenesis, as ECs coalesce into linear aggregates and organize to form central lumens that allow blood flow. Molecular mechanisms underlying in vivo vascular 'tubulogenesis' are only beginning to be unraveled. We previously showed that the GTPase-interacting protein called Rasip1 is required for the formation of continuous vascular lumens in the early embryo. Rasip1(-/-) ECs exhibit loss of proper cell polarity and cell shape, disrupted localization of EC-EC junctions and defects in adhesion of ECs to extracellular matrix. In vitro studies showed that Rasip1 depletion in cultured ECs blocked tubulogenesis. Whether Rasip1 is required in blood vessels after their initial formation remained unclear. Here, we show that Rasip1 is essential for vessel formation and maintenance in the embryo, but not in quiescent adult vessels. Rasip1 is also required for angiogenesis in three models of blood vessel growth: in vitro matrix invasion, retinal blood vessel growth and directed in vivo angiogenesis assays. Rasip1 is thus necessary in growing embryonic blood vessels, postnatal angiogenic sprouting and remodeling, but is dispensable for maintenance of established blood vessels, making it a potential anti-angiogenic therapeutic target. PMID:26897025

  14. The Effect of Oregano and Cinnamon Essential Oils on Fermentation Quality and Aerobic Stability of Field Pea Silages.

    PubMed

    Soycan-nen, Sibel; Koc, Fisun; Co?kuntuna, Levent; zdven, M Levent; Gm?, Tuncay

    2015-09-01

    This study was performed to determine the effect of field pea silages which were the organic acid (OA) alternative of oregano and cinnamon essential oils on fermentation quality and aerobic stability. Whole crop pea was harvested at full pod stage and wilted in the laboratory at the 48 h. The chopped pea was mixed and divided into equal portions allocated to five groups: CON (non-treated), distilled water, denoted as control group; OA group, a mixture of 60% formic acid, 20% sodium formate and 20% water applied at a rate of 5 g/kg fresh forage (Silofarm Liquid, Farmavet); origanum (ORE) group, Origanum onites essential oil at 400 mg/kg fresh forage; cinnamon (CIN) group, cinnamon essential oil at 400 mg/kg fresh forage; origanum+cinnamon (ORECIN) group, a mixture of ORE and CIN applied at an equal rate of 400 mg/kg fresh forage. Cinnamon decreased acetic acid (AA), ammonia nitrogen (NH3-N) and weight loss (WL) at the end of 60 days silage. Crude protein (CP) and dry matter (DM) increased by cinnamon essential oil. Yeasts were not detected in any treatments, including the control, after 7 days of air exposure. The CO2 amount decreased and the formation mold was inhibited in the aerobic period by the addition of cinnamon oil. Oregano did not show a similar effect, but when it was used with cinnamon, it showed synergic effect on AA and during aerobic period, it showed antagonistic effect on mold formation and DM losses. It was found in this study that cinnamon can be an alternative to organic acids. PMID:26323518

  15. The Effect of Oregano and Cinnamon Essential Oils on Fermentation Quality and Aerobic Stability of Field Pea Silages

    PubMed Central

    Soycan-Önenç, Sibel; Koc, Fisun; Coşkuntuna, Levent; Özdüven, M. Levent; Gümüş, Tuncay

    2015-01-01

    This study was performed to determine the effect of field pea silages which were the organic acid (OA) alternative of oregano and cinnamon essential oils on fermentation quality and aerobic stability. Whole crop pea was harvested at full pod stage and wilted in the laboratory at the 48 h. The chopped pea was mixed and divided into equal portions allocated to five groups: CON (non-treated), distilled water, denoted as control group; OA group, a mixture of 60% formic acid, 20% sodium formate and 20% water applied at a rate of 5 g/kg fresh forage (Silofarm Liquid, Farmavet); origanum (ORE) group, Origanum onites essential oil at 400 mg/kg fresh forage; cinnamon (CIN) group, cinnamon essential oil at 400 mg/kg fresh forage; origanum+cinnamon (ORECIN) group, a mixture of ORE and CIN applied at an equal rate of 400 mg/kg fresh forage. Cinnamon decreased acetic acid (AA), ammonia nitrogen (NH3-N) and weight loss (WL) at the end of 60 days silage. Crude protein (CP) and dry matter (DM) increased by cinnamon essential oil. Yeasts were not detected in any treatments, including the control, after 7 days of air exposure. The CO2 amount decreased and the formation mold was inhibited in the aerobic period by the addition of cinnamon oil. Oregano did not show a similar effect, but when it was used with cinnamon, it showed synergic effect on AA and during aerobic period, it showed antagonistic effect on mold formation and DM losses. It was found in this study that cinnamon can be an alternative to organic acids. PMID:26323518

  16. Dynamic response and stability analysis of an unbalanced flexible rotating shaft equipped with n automatic ball-balancers

    NASA Astrophysics Data System (ADS)

    Ehyaei, J.; Moghaddam, Majid M.

    2009-04-01

    The paper presents analytical and numerical investigations of a system of unbalanced flexible rotating shaft equipped with n automatic ball-balancers, where the unbalanced masses are distributed in the length of the shaft. It includes the derivation of the equations of motion, the stability analysis on the basis of linearized equations of motion around the equilibrium position, and the results of the time responses of the system. The Stodola-Green rotor model, of which the shaft is assumed flexible, is proposed for the analysis step. The rotor model includes the influence of rigid-body rotations, due to the shaft flexibility. Utilizing Lagrange's method, the nonlinear equations of motion are derived. The study shows that for the angular velocities more than the first natural frequency and selecting the suitable values for the parameters of the automatic ball-balancers, which are in the stability region, the auto ball-balancers tend to improve the vibration behavior of the system, i.e., the partial balancing, but the complete balancing was achieved in a special case, where the imbalances are in the planes of the auto ball-balancers. Furthermore, it is shown that if the auto ball-balancers are closer to the unbalanced masses, a better vibration reduction is achieved.

  17. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.

    PubMed

    Zhou, Xiao Zhen; Huang, Pengyu; Shi, Rong; Lee, Tae Ho; Lu, Gina; Zhang, Zhihong; Bronson, Roderick; Lu, Kun Ping

    2011-04-01

    Telomerase is activated in most human cancers and is critical for cancer cell growth. However, little is known about the significance of telomerase activation in chromosome instability and cancer initiation. The gene encoding the potent endogenous telomerase inhibitor PinX1 (PIN2/TRF1-interacting, telomerase inhibitor 1) is located at human chromosome 8p23, a region frequently exhibiting heterozygosity in many common human cancers, but the function or functions of PinX1 in development and tumorigenesis are unknown. Here we have shown that PinX1 is a haploinsufficient tumor suppressor essential for chromosome stability in mice. We found that PinX1 expression was reduced in most human breast cancer tissues and cell lines. Furthermore, PinX1 heterozygosity and PinX1 knockdown in mouse embryonic fibroblasts activated telomerase and led to concomitant telomerase-dependent chromosomal instability. Moreover, while PinX1-null mice were embryonic lethal, most PinX1+/- mice spontaneously developed malignant tumors with evidence of chromosome instability. Notably, most PinX1 mutant tumors were carcinomas and shared tissues of origin with human cancer types linked to 8p23. PinX1 knockout also shifted the tumor spectrum of p53 mutant mice from lymphoma toward epithelial carcinomas. Thus, PinX1 is a major haploinsufficient tumor suppressor essential for maintaining telomerase activity and chromosome stability. These findings uncover what we believe to be a novel role for PinX1 and telomerase in chromosome instability and cancer initiation and suggest that telomerase inhibition may be potentially used to treat cancers that overexpress telomerase. PMID:21436583

  18. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice

    PubMed Central

    Zhou, Xiao Zhen; Huang, Pengyu; Shi, Rong; Lee, Tae Ho; Lu, Gina; Zhang, Zhihong; Bronson, Roderick; Lu, Kun Ping

    2011-01-01

    Telomerase is activated in most human cancers and is critical for cancer cell growth. However, little is known about the significance of telomerase activation in chromosome instability and cancer initiation. The gene encoding the potent endogenous telomerase inhibitor PinX1 (PIN2/TRF1-interacting, telomerase inhibitor 1) is located at human chromosome 8p23, a region frequently exhibiting heterozygosity in many common human cancers, but the function or functions of PinX1 in development and tumorigenesis are unknown. Here we have shown that PinX1 is a haploinsufficient tumor suppressor essential for chromosome stability in mice. We found that PinX1 expression was reduced in most human breast cancer tissues and cell lines. Furthermore, PinX1 heterozygosity and PinX1 knockdown in mouse embryonic fibroblasts activated telomerase and led to concomitant telomerase-dependent chromosomal instability. Moreover, while PinX1-null mice were embryonic lethal, most PinX1+/– mice spontaneously developed malignant tumors with evidence of chromosome instability. Notably, most PinX1 mutant tumors were carcinomas and shared tissues of origin with human cancer types linked to 8p23. PinX1 knockout also shifted the tumor spectrum of p53 mutant mice from lymphoma toward epithelial carcinomas. Thus, PinX1 is a major haploinsufficient tumor suppressor essential for maintaining telomerase activity and chromosome stability. These findings uncover what we believe to be a novel role for PinX1 and telomerase in chromosome instability and cancer initiation and suggest that telomerase inhibition may be potentially used to treat cancers that overexpress telomerase. PMID:21436583

  19. BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice

    PubMed Central

    Liang, Yulong; Gao, Hong; Lin, Shiaw-Yih; Peng, Guang; Huang, Xingxu; Zhang, Pumin; Goss, John A.; Brunicardi, Francis C.; Multani, Asha S.; Chang, Sandy; Li, Kaiyi

    2010-01-01

    BRIT1 protein (also known as MCPH1) contains 3 BRCT domains which are conserved in BRCA1, BRCA2, and other important molecules involved in DNA damage signaling, DNA repair, and tumor suppression. BRIT1 mutations or aberrant expression are found in primary microcephaly patients as well as in cancer patients. Recent in vitro studies suggest that BRIT1/MCPH1 functions as a novel key regulator in the DNA damage response pathways. To investigate its physiological role and dissect the underlying mechanisms, we generated BRIT1?/? mice and identified its essential roles in mitotic and meiotic recombination DNA repair and in maintaining genomic stability. Both BRIT1?/? mice and mouse embryonic fibroblasts (MEFs) were hypersensitive to ?-irradiation. BRIT1?/? MEFs and T lymphocytes exhibited severe chromatid breaks and reduced RAD51 foci formation after irradiation. Notably, BRIT1?/? mice were infertile and meiotic homologous recombination was impaired. BRIT1-deficient spermatocytes exhibited a failure of chromosomal synapsis, and meiosis was arrested at late zygotene of prophase I accompanied by apoptosis. In mutant spermatocytes, DNA double-strand breaks (DSBs) were formed, but localization of RAD51 or BRCA2 to meiotic chromosomes was severely impaired. In addition, we found that BRIT1 could bind to RAD51/BRCA2 complexes and that, in the absence of BRIT1, recruitment of RAD51 and BRCA2 to chromatin was reduced while their protein levels were not altered, indicating that BRIT1 is involved in mediating recruitment of RAD51/BRCA2 to the damage site. Collectively, our BRIT1-null mouse model demonstrates that BRIT1 is essential for maintaining genomic stability in vivo to protect the hosts from both programmed and irradiation-induced DNA damages, and its depletion causes a failure in both mitotic and meiotic recombination DNA repair via impairing RAD51/BRCA2's function and as a result leads to infertility and genomic instability in mice. PMID:20107607

  20. The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.

    PubMed

    Akiyama, Benjamin M; Parks, Joseph W; Stone, Michael D

    2015-06-23

    Telomerase is an enzyme that adds repetitive DNA sequences to the ends of chromosomes and consists of two main subunits: the telomerase reverse transcriptase (TERT) protein and an associated telomerase RNA (TER). The telomerase essential N-terminal (TEN) domain is a conserved region of TERT proposed to mediate DNA substrate interactions. Here, we have employed single molecule telomerase binding assays to investigate the function of the TEN domain. Our results reveal telomeric DNA substrates bound to telomerase exhibit a dynamic equilibrium between two states: a docked conformation and an alternative conformation. The relative stabilities of the docked and alternative states correlate with the number of basepairs that can be formed between the DNA substrate and the RNA template, with more basepairing favoring the docked state. The docked state is further buttressed by the TEN domain and mutations within the TEN domain substantially alter the DNA substrate structural equilibrium. We propose a model in which the TEN domain stabilizes short RNA-DNA duplexes in the active site of the enzyme, promoting the docked state to augment telomerase processivity. PMID:25940626

  1. Retinoic Acid Is Essential for Th1 Cell Lineage Stability and Prevents Transition to a Th17 Cell Program

    PubMed Central

    Brown, Chrysothemis C.; Esterhazy, Daria; Sarde, Aurelien; London, Mariya; Pullabhatla, Venu; Osma-Garcia, Ines; al-Bader, Raya; Ortiz, Carla; Elgueta, Raul; Arno, Matthew; de Rinaldis, Emanuele; Mucida, Daniel; Lord, Graham M.; Noelle, Randolph J.

    2015-01-01

    Summary CD4+ T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4+ T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, the factors that regulate lineage stability are largely unknown. Here we investigate a role for retinoic acid (RA) in the regulation of lineage stability using T helper 1 (Th1) cells, traditionally considered the most phenotypically stable Th subset. We found that RA, through its receptor RARα, sustains stable expression of Th1 lineage specifying genes, as well as repressing genes that instruct Th17-cell fate. RA signaling is essential for limiting Th1-cell conversion into Th17 effectors and for preventing pathogenic Th17 responses in vivo. Our study identifies RA-RARα as a key component of the regulatory network governing maintenance and plasticity of Th1-cell fate and defines an additional pathway for the development of Th17 cells. PMID:25769610

  2. Disulfide-Mediated Stabilization of the I?B Kinase Binding Domain of NF-?B Essential Modulator (NEMO)

    PubMed Central

    2015-01-01

    Human NEMO (NF-?B essential modulator) is a 419 residue scaffolding protein that, together with catalytic subunits IKK? and IKK?, forms the I?B kinase (IKK) complex, a key regulator of NF-?B pathway signaling. NEMO is an elongated homodimer comprising mostly ?-helix. It has been shown that a NEMO fragment spanning residues 44111, which contains the IKK?/? binding site, is structurally disordered in the absence of bound IKK?. Herein we show that enforcing dimerization of NEMO1120 or NEMO44111 constructs through introduction of one or two interchain disulfide bonds, through oxidation of the native Cys54 residue and/or at position 107 through a Leu107Cys mutation, induces a stable ?-helical coiled-coil structure that is preorganized to bind IKK? with high affinity. Chemical and thermal denaturation studies showed that, in the context of a covalent dimer, the ordered structure was stabilized relative to the denatured state by up to 3 kcal/mol. A full-length NEMO-L107C protein formed covalent dimers upon treatment of mammalian cells with H2O2. Furthermore, NEMO-L107C bound endogenous IKK? in A293T cells, reconstituted TNF-induced NF-?B signaling in NEMO-deficient cells, and interacted with TRAF6. Our results indicate that the IKK? binding domain of NEMO possesses an ordered structure in the unbound state, provided that it is constrained within a dimer as is the case in the constitutively dimeric full-length NEMO protein. The stability of the NEMO coiled coil is maintained by strong interhelix interactions in the region centered on residue 54. The disulfide-linked constructs we describe herein may be useful for crystallization of NEMOs IKK? binding domain in the absence of bound IKK?, thereby facilitating the structural characterization of small-molecule inhibitors. PMID:25400026

  3. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.

    PubMed

    Shi, Wei; Bain, Amanda L; Schwer, Bjoern; Al-Ejeh, Fares; Smith, Corey; Wong, Lee; Chai, Hua; Miranda, Mariska S; Ho, Uda; Kawaguchi, Makoto; Miura, Yutaka; Finnie, John W; Wall, Meaghan; Heierhorst, Jrg; Wicking, Carol; Spring, Kevin J; Alt, Frederick W; Khanna, Kum Kum

    2013-01-01

    Single-stranded DNA binding proteins (SSBs) regulate multiple DNA transactions, including replication, transcription, and repair. We recently identified SSB1 as a novel protein critical for the initiation of ATM signaling and DNA double-strand break repair by homologous recombination. Here we report that germline Ssb1(-/-) embryos die at birth from respiratory failure due to severe rib cage malformation and impaired alveolar development, coupled with additional skeletal defects. Unexpectedly, Ssb1(-/-) fibroblasts did not exhibit defects in Atm signaling or ?-H2ax focus kinetics in response to ionizing radiation (IR), and B-cell specific deletion of Ssb1 did not affect class-switch recombination in vitro. However, conditional deletion of Ssb1 in adult mice led to increased cancer susceptibility with broad tumour spectrum, impaired male fertility with testicular degeneration, and increased radiosensitivity and IR-induced chromosome breaks in vivo. Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo. PMID:23408915

  4. Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2

    PubMed Central

    Schwer, Bjoern; Al-Ejeh, Fares; Smith, Corey; Wong, Lee; Chai, Hua; Miranda, Mariska S.; Ho, Uda; Kawaguchi, Makoto; Miura, Yutaka; Finnie, John W.; Wall, Meaghan; Heierhorst, Jrg; Wicking, Carol; Spring, Kevin J.; Alt, Frederick W.; Khanna, Kum Kum

    2013-01-01

    Single-stranded DNA binding proteins (SSBs) regulate multiple DNA transactions, including replication, transcription, and repair. We recently identified SSB1 as a novel protein critical for the initiation of ATM signaling and DNA double-strand break repair by homologous recombination. Here we report that germline Ssb1?/? embryos die at birth from respiratory failure due to severe rib cage malformation and impaired alveolar development, coupled with additional skeletal defects. Unexpectedly, Ssb1?/? fibroblasts did not exhibit defects in Atm signaling or ?-H2ax focus kinetics in response to ionizing radiation (IR), and B-cell specific deletion of Ssb1 did not affect class-switch recombination in vitro. However, conditional deletion of Ssb1 in adult mice led to increased cancer susceptibility with broad tumour spectrum, impaired male fertility with testicular degeneration, and increased radiosensitivity and IRinduced chromosome breaks in vivo. Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo. PMID:23408915

  5. Preferential solubilization behaviours and stability of some phenolic-bearing essential oils formulated in different microemulsion systems.

    PubMed

    Edris, A E; Malone, C F R

    2012-10-01

    The solubilization behaviour of a number of essential oils (EOs) containing volatile phenolic constituents was investigated in five different micellar solutions. These oils include clove bud (Eugenia caryophyllata), thyme (Thymus serpyllum) and oregano (Thymus capitatus). Ternary and pseudo-ternary phase diagrams were constructed to assess the ability for microemulsion formation and dilutability of each system using non-ionic surfactants. Results showed that Tween 20 (T20) was more suitable to solubilize these oils compared with Tween 80 (T80). Clove EO was found to be easily microemulsifiable compared with the other EOs, whereas oregano showed the least tendency to form a microemulsion. Particle sizes measured at different dilution lines ranged between 5.9 and 16.9 nm. The chemical composition of each EO was revealed by gas chromatography and was correlated with the observed solubilization behaviour. The presence of solubilization enhancers like poly-ols and short-chain alcohols improved solubilization of all EOs; however, establishment of new dilution lines was controlled by EO type. Physical stability assessment showed that all microemulsions were stable against alternate freeze/thaw cycles which extended for 1 week. On the contrary, each system showed different temperature sensitivity in the thermal stress assessment. The results of this investigation can be useful in fabrication of thermodynamically stable aqueous system carrying aromatic and bioactive phenolics for different applications in personal hygiene, cosmetic, fragrance and pharmaceutical products. PMID:22738164

  6. Sumoylation Is Important for Stability, Subcellular Localization, and Transcriptional Activity of SALL4, an Essential Stem Cell Transcription Factor*

    PubMed Central

    Yang, Feikun; Yao, Yixin; Jiang, Yongping; Lu, Luo; Ma, Yupo; Dai, Wei

    2012-01-01

    SALL4 is a transcription factor that plays a key role in the maintenance and self-renewal of embryonic stem cells and hematopoietic stem cells. Given that little is known about regulation of SALL4, we studied biochemical modifications of SALL4B, a major splicing variant of SALL4, and elucidated their biological function. SALL4B was primarily modified by ubiquitination when it was expressed in both Sf9 and HEK293T cells. A significant fraction of SALL4B was further modified by sumoylation when it was expressed in HEK293T cells. Constitutive SUMO-modification of SALL4B was also detected in Tera-1, a cell line of the teratocarcinoma origin. SALL4B sumoylation was independent of ubiquitination and lysine residues 156, 316, 374, and 401 were essential for sumoylation. Chromatin fraction contained more SUMO-deficient SALL4B. Despite a shorter half-life than the wild-type counterpart, SUMO-deficient SALL4B interacted with OCT4 more efficiently than the wild-type SALL4B. RNAi-mediated silencing of SALL4 expression caused significant down-regulation of both OCT4 and SOX2, which was rescued by ectopic expression of SALL4B but not by SUMO-deficient mutant. Significantly, compared with the wild-type SALL4B, SUMO-deficient mutant exhibited compromised trans-activation or trans-repression activities in reporter gene assays. Combined, our studies reveal sumoylation as a novel form of post-translational modification for regulating the stability, subcellular localization, and transcriptional activity of SALL4. PMID:23012367

  7. Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor.

    PubMed

    Yang, Feikun; Yao, Yixin; Jiang, Yongping; Lu, Luo; Ma, Yupo; Dai, Wei

    2012-11-01

    SALL4 is a transcription factor that plays a key role in the maintenance and self-renewal of embryonic stem cells and hematopoietic stem cells. Given that little is known about regulation of SALL4, we studied biochemical modifications of SALL4B, a major splicing variant of SALL4, and elucidated their biological function. SALL4B was primarily modified by ubiquitination when it was expressed in both Sf9 and HEK293T cells. A significant fraction of SALL4B was further modified by sumoylation when it was expressed in HEK293T cells. Constitutive SUMO-modification of SALL4B was also detected in Tera-1, a cell line of the teratocarcinoma origin. SALL4B sumoylation was independent of ubiquitination and lysine residues 156, 316, 374, and 401 were essential for sumoylation. Chromatin fraction contained more SUMO-deficient SALL4B. Despite a shorter half-life than the wild-type counterpart, SUMO-deficient SALL4B interacted with OCT4 more efficiently than the wild-type SALL4B. RNAi-mediated silencing of SALL4 expression caused significant down-regulation of both OCT4 and SOX2, which was rescued by ectopic expression of SALL4B but not by SUMO-deficient mutant. Significantly, compared with the wild-type SALL4B, SUMO-deficient mutant exhibited compromised trans-activation or trans-repression activities in reporter gene assays. Combined, our studies reveal sumoylation as a novel form of post-translational modification for regulating the stability, subcellular localization, and transcriptional activity of SALL4. PMID:23012367

  8. X-ray sensing materials stability: influence of ambient storage temperature on essential thermal properties of undoped vitreous selenium

    NASA Astrophysics Data System (ADS)

    Tonchev, D.; Mani, H.; Belev, G.; Kostova, I.; Kasap, S.

    2014-12-01

    Amorphous selenium (a-Se) is currently used in x-ray image detectors as an x-ray photoconductor. Normally a-Se films used in device applications are fabricated by the evaporation of vitreous bulk material loaded into boats in a typical vacuum deposition system. The resistance against crystallization is an important factor in both film and bulk forms of a-Se. Previous work has indicted that the resistance to crystallization is surprisingly more pronounced around 35 C [1]. In this work we have therefore examined the essential thermal properties of vitreous selenium (99.999%) samples that have been stored at different temperatures. The thermal characterization experiments involved a series of DSC (Differential Scanning Calorimetry) measurements in which have monitored the glass transition and melting endotherms, and the crystallization exotherm in heating-cooling-heating scans. In DSC experiments, a sample would be heated to a temperature above the melting temperature, equilibrated, then cooled at a fixed rate down to 20 C, then equilibrated and finally scanned again under a heating schedule. The samples were isothermally stored at temperatures corresponding to 18, 35 and 55 C. The thermal analysis results show that there are distinct differences in the thermal properties. We have examined the stability in terms of the difference in the crystallization onset temperature (Tc) and the onset of glass transition temperature (Tg). We also examined the Hruby coefficient (Kgl) of these samples, that is Kgl = (Tc - Tg)/(Tm - Tc) where Tc is the crystallization onset temperature and Tm is the melting onset temperature. We have found Kgl to depend on the storage temperature. Surprisingly, we observed that the Hruby coefficient is actually larger at 35 C compared to the values at 18 and 55 C.

  9. The comparative efficacy of stabilized stannous fluoride dentifrice, peroxide/baking soda dentifrice and essential oil mouthrinse for the prevention of gingivitis.

    PubMed

    Beiswanger, B B; McClanahan, S F; Bartizek, R D; Lanzalaco, A C; Bacca, L A; White, D J

    1997-01-01

    This double-blind parallel-design clinical study compared the efficacy of a stabilized stannous fluoride dentifrice (Crest Plus Gum Care), baking soda and peroxide (NaF) dentifrice (Mentadent), and essential oil mouthrinse (Listerine) to a conventional NaF dentifrice (Crest) for the control of plaque, gingivitis and gingival bleeding over six months. Following an initial baseline examination and stratification, subjects received a complete oral prophylaxis and were distributed assigned test products. Following three and six months, subjects re-visited the clinic for examinations. Evaluations at baseline and at 3 and 6 months included soft tissue status. Le-Silness gingivitis/gingival bleeding, Silness-Le plaque and dental stain. Results subsequent to six months of product use were as follows: At six months, the stabilized stannous fluoride dentifrice was observed to produce statistically significant 17.5% reductions in gingivitis and 27.5% reductions in gingival bleeding relative to the NaF dentifrice. The combination of sodium fluoride dentifrice and essential oil mouthrinse produced statistically significant reductions of 7.4% in gingivitis and 10.8% in plaque as compared with the NaF dentifrice. The stabilized stannous fluoride dentifrice produced statistically significant reductions in both gingivitis (10.8%) and gingival bleeding (23.0%) relative to the combination of sodium fluoride dentifrice and essential oil mouthrinse. The baking soda and peroxide (NaF) dentifrice did not provide reductions in gingivitis, plaque or gingival bleeding as compared with the conventional NaF dentifrice. The stabilized stannous fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following six months of use, and both the essential oil mouthrinse and stabilized stannous fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following three months of use. These results support: 1) the efficacy of stabilized stannous fluoride dentifrice and the combination of sodium fluoride dentifrice and essential oil mouthrinse for the prevention of gingivitis; 2) the superior activity of stabilized stannous fluoride dentifrice as compared with a combination of sodium fluoride dentifrice and essential oil mouthrinse for the control of gingivitis and gingival bleeding; and 3) the lack of efficacy for baking soda and peroxide dentifrice for the control of plaque, gingivitis and gingival bleeding as compared with conventional fluoridated dentifrice. PMID:9238873

  10. Subunit CydX of Escherichia coli cytochrome bd ubiquinol oxidase is essential for assembly and stability of the di-heme active site.

    PubMed

    Hoeser, Jo; Hong, Sangjin; Gehmann, Gerfried; Gennis, Robert B; Friedrich, Thorsten

    2014-05-01

    Cytochrome bd ubiquinol oxidase uses the electron transport from ubiquinol to oxygen to establish a proton gradient across the membrane. The enzyme complex consists of subunits CydA and B and contains two b- and one d-type hemes as cofactors. Recently, it was proposed that a third subunit named CydX is essential for the function of the complex. Here, we show that CydX is indeed a subunit of purified Escherichia coli cytochrome bd oxidase and that the small protein is needed either for the assembly or the stability of the active site di-heme center and, thus, is essential for oxidase activity. PMID:24681096

  11. The antioxidant status and oxidative stability of muscle from lambs receiving oral administration of Artemisia herba alba and Rosmarinus officinalis essential oils.

    PubMed

    Aouadi, Dorra; Luciano, Giuseppe; Vasta, Valentina; Nasri, Saida; Brogna, Daniela M R; Abidi, Sourour; Priolo, Alessandro; Salem, Hichem Ben

    2014-06-01

    The effect of the dietary supplementation to lambs of essential oils (EOs) from rosemary (Rosmarinus officinalis) and artemisia (Artemisia herba alba) on the antioxidant status of muscle and on meat oxidative stability was studied. Eighteen Barbarine lambs were divided into 3 groups and for 95days received oat hay and concentrates. One group (C) was not supplemented, while the other two groups received 400mg/kg of EOs from rosemary (R400) or artemisia (A400). Both EOs possessed antioxidant properties and their oral administration improved the reducing and radical scavenging capacity of the muscle compared to the C treatment (P<0.01). Nevertheless, supplementing EOs did not exert protection against lipid oxidation and did not affect the colour stability in meat over 7days of aerobic storage. PMID:24583334

  12. Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection

    PubMed Central

    Seu, Lillian; Sabbaj, Steffanie; Duverger, Alexandra; Wagner, Frederic; Anderson, Joshua C.; Davies, Elizabeth; Wolschendorf, Frank; Willey, Christopher D.; Saag, Michael S.; Goepfert, Paul

    2015-01-01

    ABSTRACT The extreme stability of the latent HIV-1 reservoir in the CD4+ memory T cell population prevents viral eradication with current antiretroviral therapy. It has been demonstrated that homeostatic T cell proliferation and clonal expansion of latently infected T cells due to viral integration into specific genes contribute to this extraordinary reservoir stability. Nevertheless, given the constant exposure of the memory T cell population to specific antigen or bystander activation, this reservoir stability seems remarkable, unless it is assumed that latent HIV-1 resides exclusively in memory T cells that recognize rare antigens. Another explanation for the stability of the reservoir could be that the latent HIV-1 reservoir is associated with an unresponsive T cell phenotype. We demonstrate here that host cells of latent HIV-1 infection events were functionally altered in ways that are consistent with the idea of an anergic, unresponsive T cell phenotype. Manipulations that induced or mimicked an anergic T cell state promoted latent HIV-1 infection. Kinome analysis data reflected this altered host cell phenotype at a system-wide level and revealed how the stable kinase activity changes networked to stabilize latent HIV-1 infection. Protein-protein interaction networks generated from kinome data could further be used to guide targeted genetic or pharmacological manipulations that alter the stability of latent HIV-1 infection. In summary, our data demonstrate that stable changes to the signal transduction and transcription factor network of latently HIV-1 infected host cells are essential to the ability of HIV-1 to establish and maintain latent HIV-1 infection status. IMPORTANCE The extreme stability of the latent HIV-1 reservoir allows the infection to persist for the lifetime of a patient, despite completely suppressive antiretroviral therapy. This extreme reservoir stability is somewhat surprising, since the latently HIV-1 infected CD4+ memory T cells that form the structural basis of the viral reservoir should be exposed to cognate antigen over time. Antigen exposure would trigger a recall response and should deplete the reservoir, likely over a relatively short period. Our data demonstrate that stable and system-wide phenotypic changes to host cells are a prerequisite for the establishment and maintenance of latent HIV-1 infection events. The changes observed are consistent with an unresponsive, anergy-like T cell phenotype of latently HIV-1 infected host cells. An anergy-like, unresponsive state of the host cells of latent HIV-1 infection events would explain the stability of the HIV-1 reservoir in the face of continuous antigen exposure. PMID:25878110

  13. Experimental Verification of the Rudder-Free Stability Theory for an Airplane Model Equipped with Rudders Having Negative Floating Tendency and Negligible Friction

    NASA Technical Reports Server (NTRS)

    McKinney, Marion O.; Maggin, Bernard

    1944-01-01

    An investigation has been made in the Langley free-flight tunnel to obtain an experimental verification of the theoretical rudder-free stability characteristics of an airplane model equipped with conventional rudders having negative floating tendencies and negligible friction. The model used in the tests was equipped with a conventional single vertical tail having rudder area 40 percent of the vertical tail area. The model was tested both in free flight and mounted on a strut that allowed freedom only in yaw. Tests were made with three different amounts of rudder aerodynamic balance and with various values of mass, moment of inertia, and center-of-gravity location of the rudder. Most of the stability derivatives required for the theoretical calculations were determined from forced and free-oscillation tests of the particular model tested. The theoretical analysis showed that the rudder-free motions of an airplane consist largely of two oscillatory modes - a long-period oscillation somewhat similar to the normal rudder-fixed oscillation and a short-period oscillation introduced only when the rudder is set free. It was found possible in the tests to create lateral instability of the rudder-free short-period mode by large values of rudder mass parameters even though the rudder-fixed condition was highly stable. The results of the tests and calculation indicated that for most present-day airplanes having rudders of negative floating tendency, the rudder-free stability characteristics may be examined by simply considering the dynamic lateral stability using the value of the directional-stability parameter Cn(sub p) for the rudder-free condition in the conventional controls-fixed lateral-stability equations. For very large airplanes having relatively high values of the rudder mass parameters with respect to the rudder aerodynamic parameters, however, analysis of the rudder-free stability should be made with the complete equations of motion. Good agreement between calculated and measured rudder-free stability characteristics was obtained by use of the general rudder-free stability theory, in which four degrees of lateral freedom are considered. When this assumption is made that the rolling motions alone or the lateral and rolling motions may be neglected in the calculations of rudder-free stability, it is possible to predict satisfactorily the characteristics of the long-period (Dutch roll type) rudder-free oscillation for airplanes only when the effective-dihedral angle is small. With these simplifying assumptions, however, satisfactory prediction of the short-period oscillation may be obtained for any dihedral. Further simplification of the theory based on the assumption that the rudder moment of inertia might be disregarded was found to be invalid because this assumption made it impossible to calculate the characteristics of the short-period oscillations.

  14. Structural Stability of Human Fibroblast Growth Factor-1 Is Essential for Protective Effects Against Radiation-Induced Intestinal Damage

    SciTech Connect

    Nakayama, Fumiaki; Umeda, Sachiko; Yasuda, Takeshi; Asada, Masahiro; Motomura, Kaori; Suzuki, Masashi; Zakrzewska, Malgorzata; Imamura, Toru; Imai, Takashi

    2013-02-01

    Purpose: Human fibroblast growth factor-1 (FGF1) has radioprotective effects on the intestine, although its structural instability limits its potential for practical use. Several stable FGF1 mutants were created increasing stability in the order, wild-type FGF1, single mutants (Q40P, S47I, and H93G), Q40P/S47I, and Q40P/S47I/H93G. This study evaluated the contribution of the structural stability of FGF1 to its radioprotective effect. Methods and Materials: Each FGF1 mutant was administered intraperitoneally to BALB/c mice in the absence of heparin 24 h before or after total body irradiation (TBI) with {gamma}-rays at 8-12 Gy. Several radioprotective effects were examined in the jejunum. Results: Q40P/S47I/H93G could activate all subtypes of FGF receptors in vitro much more strongly than the wild-type without endogenous or exogenous heparin. Preirradiation treatment with Q40P/S47I/H93G significantly increased crypt survival more than wild-type FGF1 after TBI at 10 or 12 Gy, and postirradiation treatment with Q40P/S47I/H93G was effective in promoting crypt survival after TBI at 10, 11, or 12 Gy. In addition, crypt cell proliferation, crypt depth, and epithelial differentiation were significantly promoted by postirradiation treatment with Q40P/S47I/H93G. The level of stability of FGF1 mutants correlated with their mitogenic activities in vitro in the absence of heparin; however, preirradiation treatment with the mutants increased the crypt number to almost the same level as Q40P/S47I/H93G. When given 24 h after TBI at 10 Gy, all FGF1 mutants increased crypt survival more than wild-type FGF1, and Q40P/S47I/H93G had the strongest mitogenic effects in intestinal epithelial cells after radiation damage. Moreover, Q40P/S47I/H93G prolonged mouse survival after TBI because of the repair of intestinal damage. Conclusion: These findings suggest that the structural stability of FGF1 can contribute to the enhancement of protective effects against radiation-induced intestinal damage. Therefore, Q40P/S47I/H93G is pharmacologically one of the most promising candidates for clinical applications for radiation-induced gastrointestinal syndrome.

  15. Fabrication, stability and efficacy of dual-component antimicrobial nanoemulsions: essential oil (thyme oil) and cationic surfactant (lauric arginate).

    PubMed

    Chang, Yuhua; McLandsborough, Lynne; McClements, David Julian

    2015-04-01

    The influence of a cationic surfactant (lauric arginate, LAE) on the physical properties and antimicrobial efficacy of thyme oil nanoemulsions was investigated. Nanoemulsions prepared from pure thyme oil were highly unstable due to Ostwald ripening, but they could be stabilized by adding a ripening inhibitor (corn oil) to the oil phase prior to homogenisation. The loading capacity and antimicrobial efficacy of thyme oil nanoemulsions were significantly increased by adding LAE. In the absence of LAE, at least 60 wt% corn oil had to be added to the lipid phase to inhibit Ostwald ripening; but in the presence of 0.1 wt% LAE, only 30 wt% corn oil was needed. LAE addition substantially increased the antimicrobial efficacy of the thyme oil nanoemulsions: 200 ?g/ml thyme oil was needed to inhibit growth of a spoilage yeast (Zygosaccharomyces bailii) if LAE was added, whereas ? 400 ?g/ml was needed in the absence of LAE. PMID:25442557

  16. Stabilities of thiomolybdate complexes of iron; implications for retention of essential trace elements (Fe, Cu, Mo) in sulfidic waters.

    PubMed

    Helz, George R; Erickson, Britt E; Vorlicek, Trent P

    2014-06-01

    In aquatic ecosystems, availabilities of Fe, Mo and Cu potentially limit rates of critical biological processes, including nitrogen fixation, nitrate assimilation and N2O decomposition. During long periods in Earth's history when large parts of the ocean were sulfidic, what prevented these elements' quantitative loss from marine habitats as insoluble sulfide phases? They must have been retained by formation of soluble complexes. Identities of the key ligands are poorly known but probably include thioanions. Here, the first determinations of stability constants for Fe(2+)-[MoS4](2-) complexes in aqueous solution are reported based on measurements of pyrrhotite (hexagonal FeS) solubility under mildly alkaline conditions. Two linear complexes, [FeO(OH)MoS4](3-) and [(Fe2S2)(MoS4)2](4-), best explain the observed solubility variations. Complexes that would be consistent with cuboid cluster structures were less successful, implying that such clusters probably are minor or absent in aqueous solution under the conditions studied. The new data, together with prior data on stabilities of Cu(+)-[MoS4](2-) complexes, are used to explore computationally how competition of Fe(2+) and Cu(+) for [MoS4](2-), as well as competition of [MoS4](2-) and HS(-) for both metals would be resolved in solutions representative of sulfidic natural waters. Thiomolybdate complexes will be most important at sulfide concentrations near the [MoO4](2-)-[MoS4](2-) equivalence point. At lower sulfide concentrations, thiomolybdates are insufficiently stable to be competitive ligands in natural waters and at higher sulfide concentrations HS(-) ligands out-compete thiomolybdates. PMID:24226648

  17. Essential role of the N- and C-terminals of laccase from Pleurotus florida on the laccase activity and stability.

    PubMed

    Hu, Meirong; Zhou, Xue; Shi, Yiping; Lin, Jianhui; Irfan, Muhammad; Tao, Yong

    2014-11-01

    POXA1b is the most thermostable laccase isoenzyme from Pleurotus ostreatus. POXA1b is remarkably stable at alkaline pH (the t1/2 at pH 10 was 30 days), and its C-terminal affects its catalytic and stability properties. We cloned POXA1c from P. florida, which showed 99 % identity with POXA1b. POXA1c was functionally expressed in Pichia pastoris. The functions of the N and C termini of POXA1c were investigated using site-directed mutagenesis. Compared with POXA1c, the N-terminal R5V site effectively increased the specific activities for 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and guaiacol by 2- and 3.5-fold, respectively. A C-terminal truncated mutant, POXA1c?13, also increased the specific activities for ABTS and guaiacol by 2.3- and 3.4-fold, respectively. A double mutant, POXA1c?13-R5V, combined the R5V and ?13 effects. The specific activity of this double mutant for ABTS was 1,321 U/mg, which indicated a 4-fold increase compared with the wild type. The role of residue V5 on laccase catalytic properties was also observed for laccases from Trametes versicolor and Rigidoporus lignosus. The specific activities of the V5R of the laccases from T. versicolor and R. lignosus were half of that of the wild type. The pH and thermal stability analysis of POXA1c and its mutants showed that the enzymes were remarkably stable because they showed 63 % residual activity after incubation for 108 h at 30 C over a pH range of 4.5 to 9.0. Similar results were observed for POXA1c?13-R5V. POXA1c?13-R5V can be widely used in industrial biotechnology because of its excellent catalytic properties. PMID:25161036

  18. Effect of thyme/cumin essential oils and butylated hydroxyl anisole/butylated hydroxyl toluene on physicochemical properties and oxidative/microbial stability of chicken patties.

    PubMed

    Sariçoban, Cemalettin; Yilmaz, Mustafa Tahsin

    2014-02-01

    In this study, effects of thyme/cumin essential oils (EO) and butylated hydroxyl anisole (BHA)/butylated hydroxyl toluene (BHT) on physicochemical properties and storage stability of chicken patties were compared in different storage periods (0, 3, 7, 14, 21, and 28 d). It was found that there were significant (P < 0.05) differences between physicochemical properties of patty samples treated with EO and the synthetic antioxidants. The EO showed similar performance to those of BHA and BHT in limiting TBARS values of chicken patty samples. Similarity in performance was also the case for microbial stability (total aerobic mesophilic, psychrotrophic, lactic acid, and coliform bacteria as well as molds and yeasts); namely, their effects were significant (P < 0.05). Effect of thyme EO was significant (P < 0.05) and remarkable, not allowing any coliform bacteria to grow in the samples. Given that EO were obtained from natural sources, the data suggested that the EO might be more useful than their synthetic counterparts, BHA and BHT, as additives for chicken patties to maintain oxidative/microbial stability and increase shelf life. PMID:24570469

  19. The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability

    SciTech Connect

    Choi, Myung-Suk; Min, Sang-Hyun; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 ; Jung, Haiyoung; Lee, Ju Dong; Lee, Tae Ho; Lee, Heung Kyu; Yoo, Ook-Joon

    2011-03-11

    Research highlights: {yields} FKBP38 interacts with PRL-3. {yields} FKBP38 promotes degradation of endogenous PRL-3 protein via protein-proteasome pathway. {yields} FKBP38 suppresses PRL-3 oncogenic function. {yields} FKBP38 is a novel negative regulator of the oncogenic protein PRL-3. -- Abstract: The phosphatase of regenerating liver-3 (PRL-3) is a member of protein tyrosine phosphatases and whose deregulation is implicated in tumorigenesis and metastasis of many cancers. However, the underlying mechanism by which PRL-3 is regulated is not known. In this study, we identified the peptidyl prolyl cis/trans isomerase FK506-binding protein 38 (FKBP38) as an interacting protein of PRL-3 using a yeast two-hybrid system. FKBP38 specifically binds to PRL-3 in vivo, and that the N-terminal region of FKBP38 is crucial for binding with PRL-3. FKBP38 overexpression reduces endogenous PRL-3 expression levels, whereas the depletion of FKBP38 by siRNA increases the level of PRL-3 protein. Moreover, FKBP38 promotes degradation of endogenous PRL-3 protein via protein-proteasome pathway. Furthermore, FKBP38 suppresses PRL-3-mediated p53 activity and cell proliferation. These results demonstrate that FKBP38 is a novel regulator of the oncogenic protein PRL-3 abundance and that alteration in the stability of PRL-3 can have a dramatic impact on cell proliferation. Thus, FKBP38 may play a critical role in tumorigenesis.

  20. InSAC: A novel sub-nuclear body essential for Interleukin-6 and -10 RNA processing and stability

    PubMed Central

    Park, Boyoun

    2015-01-01

    Dysregulation of cytokine expression causes inflammatory diseases or chronic infection conditions. We have identified that Tat-activating regulatory DNA-binding protein-43 (TDP-43) is involved in cytokine RNA processing in order to promote an optimal immune response. The interaction of TDP-43 with spliceosomal components from the Cajal body leads to the formation of a novel sub-nuclear body called the Interleukin (IL)-6 and IL-10 Splicing Activating Compartment (InSAC). TDP-43 binds to the IL-6 and IL-10 RNAs in a sequence-dependent manner. In cell-based studies, we observed that lipopoly-saccharide (LPS) stimulation induces the formation of the InSAC through TDP-43 ubiquitination, thereby influencing the processing and expression levels of IL-6 RNA. Moreover, TDP-43 knockdown in vivo results in a decrease in IL-6 production and its RNA splicing and stability. Thus, these findings demonstrate that the InSAC is linked to the activation and modulation of the immune response. [BMB Reports 2015; 48(5): 239-240] PMID:25845943

  1. Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice.

    PubMed

    Dovey, Oliver M; Foster, Charles T; Conte, Nathalie; Edwards, Sally A; Edwards, Jennifer M; Singh, Rajinder; Vassiliou, George; Bradley, Allan; Cowley, Shaun M

    2013-02-21

    Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better understand the key pathways regulated by HDAC1/2 in the adaptive immune system and inform their exploitation as drug targets, we have generated mice with a T-cell specific deletion. Loss of either HDAC1 or HDAC2 alone has little effect, while dual inactivation results in a 5-fold reduction in thymocyte cellularity, accompanied by developmental arrest at the double-negative to double-positive transition. Transcriptome analysis revealed 892 misregulated genes in Hdac1/2 knock-out thymocytes, including down-regulation of LAT, Themis and Itk, key components of the T-cell receptor (TCR) signaling pathway. Down-regulation of these genes suggests a model in which HDAC1/2 deficiency results in defective propagation of TCR signaling, thus blocking development. Furthermore, mice with reduced HDAC1/2 activity (Hdac1 deleted and a single Hdac2 allele) develop a lethal pathology by 3-months of age, caused by neoplastic transformation of immature T cells in the thymus. Tumor cells become aneuploid, express increased levels of c-Myc and show elevated levels of the DNA damage marker, ?H2AX. These data demonstrate a crucial role for HDAC1/2 in T-cell development and the maintenance of genomic stability. PMID:23287868

  2. A conserved π-cation and an electrostatic bridge are essential for 11R-lipoxygenase catalysis and structural stability.

    PubMed

    Eek, Priit; Piht, Mari-Ann; Rätsep, Margus; Freiberg, Arvi; Järving, Ivar; Samel, Nigulas

    2015-10-01

    Lipoxygenases (LOXs) are lipid-peroxidizing enzymes that consist of a regulatory calcium- and membrane-binding PLAT (polycystin-1, lipoxygenase, α-toxin) domain and a catalytic domain. In a previous study, the crystal structure of an 11R-LOX revealed a conserved π-cation bridge connecting these two domains which could mediate the regulatory effect of the PLAT domain to the active site. Here we analyzed the role of residues Trp107 and Lys172 that constitute the π-cation bridge in 11R-LOX along with Arg106 and Asp173-a potential salt bridge, which could also contribute to the inter-domain communication. According to our kinetic assays and protein unfolding experiments conducted using differential scanning fluorimetry and circular dichroism spectroscopy, mutants with a disrupted link display diminished catalytic activity alongside reduced stability of the protein fold. The results demonstrate that both these bridges contribute to the two-domain interface, and are important for proper enzyme activation. PMID:26215075

  3. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes

    PubMed Central

    Zemljic-Harpf, Alice E.; Godoy, Joseph C.; Platoshyn, Oleksandr; Asfaw, Elizabeth K.; Busija, Anna R.; Domenighetti, Andrea A.; Ross, Robert S.

    2014-01-01

    ABSTRACT Vinculin (Vcl) links actin filaments to integrin- and cadherin-based cellular junctions. Zonula occludens-1 (ZO-1, also known as TJP1) binds connexin-43 (Cx43, also known as GJA1), cadherin and actin. Vcl and ZO-1 anchor the actin cytoskeleton to the sarcolemma. Given that loss of Vcl from cardiomyocytes causes maldistribution of Cx43 and predisposes cardiomyocyte-specific Vcl-knockout mice with preserved heart function to arrhythmia and sudden death, we hypothesized that Vcl and ZO-1 interact and that loss of this interaction destabilizes gap junctions. We found that Vcl, Cx43 and ZO-1 colocalized at the intercalated disc. Loss of cardiomyocyte Vcl caused parallel loss of ZO-1 from intercalated dics. Vcl co-immunoprecipitated Cx43 and ZO-1, and directly bound ZO-1 in yeast two-hybrid studies. Excision of the Vcl gene in neonatal mouse cardiomyocytes caused a reduction in the amount of Vcl mRNA transcript and protein expression leading to (1) decreased protein expression of Cx43, ZO-1, talin, and β1D-integrin, (2) reduced PI3K activation, (3) increased activation of Akt, Erk1 and Erk2, and (4) cardiomyocyte necrosis. In summary, this is the first study showing a direct interaction between Vcl and ZO-1 and illustrates how Vcl plays a crucial role in stabilizing gap junctions and myocyte integrity. PMID:24413171

  4. Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression.

    PubMed

    Yuri, Shunsuke; Fujimura, Sayoko; Nimura, Keisuke; Takeda, Naoki; Toyooka, Yayoi; Fujimura, Yu-Ichi; Aburatani, Hiroyuki; Ura, Kiyoe; Koseki, Haruhiko; Niwa, Hitoshi; Nishinakamura, Ryuichi

    2009-04-01

    Sall4 is a mouse homolog of a causative gene of the autosomal dominant disorder Okihiro syndrome. We previously showed that the absence of Sall4 leads to lethality during peri-implantation and that Sall4-null embryonic stem (ES) cells proliferate poorly with intact pluripotency when cultured on feeder cells. Here, we report that, in the absence of feeder cells, Sall4-null ES cells express the trophectoderm marker Cdx2, but are maintained for a long period in an undifferentiated state with minimally affected Oct3/4 expression. Feeder-free Sall4-null ES cells contribute solely to the inner cell mass and epiblast in vivo, indicating that these cells still retain pluripotency and do not fully commit to the trophectoderm. These phenotypes could arise from derepression of the Cdx2 promoter, which is normally suppressed by Sall4 and the Mi2/NuRD HDAC complex. However, proliferation was impaired and G1 phase prolonged in the absence of Sall4, suggesting another role for Sall4 in cell cycle control. Although Sall1, also a Sall family gene, is known to genetically interact with Sall4 in vivo, Sall1-null ES cells have no apparent defects and no exacerbation is observed in ES cells lacking both Sall1 and Sall4, compared with Sall4-null cells. This suggests a unique role for Sall4 in ES cells. Thus, though Sall4 does not contribute to the central machinery of the pluripotency, it stabilizes ES cells by repressing aberrant trophectoderm gene expression. PMID:19350679

  5. Stabilization of Speckle-type POZ Protein (Spop) by Daz Interacting Protein 1 (Dzip1) Is Essential for Gli Turnover and the Proper Output of Hedgehog Signaling*

    PubMed Central

    Schwend, Tyler; Jin, Zhigang; Jiang, Kai; Mitchell, Brian J.; Jia, Jianhang; Yang, Jing

    2013-01-01

    The Hedgehog (Hh) pathway is essential for embryonic development and adult tissue homeostasis. The Gli/Cubitus interruptus (Ci) family of transcription factors acts at the downstream end of the pathway to mediate Hh signaling. Both Hh-dependent and -independent Gli regulatory mechanisms are important for the output of Hh signaling. Daz interacting protein 1 (Dzip1) has bipartite positive and negative functions in the Hh pathway. The positive Hh regulatory function appears to be attributed to a requirement for Dzip1 during ciliogenesis. The mechanism by which Dzip1 inhibits Hh signaling, however, remains largely unclear. We recently found that Dzip1 is required for Gli turnover, which may account for its inhibitory function in Hh signaling. Here, we report that Dzip1 regulates Gli/Ci turnover by preventing degradation of speckle-type POZ protein (Spop), a protein that promotes proteasome-dependent turnover of Gli proteins. We provide evidence that Dzip1 regulates the stability of Spop independent of its function in ciliogenesis. Partial knockdown of Dzip1 to levels insufficient for perturbing ciliogenesis, sensitized Xenopus embryos to Hh signaling, leading to phenotypes that resemble activation of Hh signaling. Importantly, overexpression of Spop was able to restore proper Gli protein turnover and rescue phenotypes in Dzip1-depleted embryos. Consistently, depletion of Dzip1 in Drosophila S2 cells destabilized Hh-induced BTB protein (HIB), the Drosophila homolog of Spop, and increased the level of Ci. Thus, Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway. PMID:24072710

  6. Anti-rancidity effect of essential oils, application in the lipid stability of cooked turkey meat patties and potential implications for health.

    PubMed

    Loizzo, Monica R; Tundis, Rosa; Menichini, Francesco; Duthie, Garry

    2015-02-01

    Twenty-three commercial essential oils were tested for their anti-rancidity effect and potential implications to prolong the induction time of corn oil and extend the shelf life of cooked turkey patties. Moreover, the potential health benefit was investigated through DPPH, ABTS, β-carotene bleaching, FRAP, and α-amylase inhibitory assays. Essential oils' composition was investigated by GC-MS. Cumin, thyme, clove, and cinnamon oils improved oxidative stability and increased the induction time of the corn oil 1.5-3 fold. Clove and cinnamon oils were particularly effective in delaying lipid oxidation of cooked turkey patties (time of induction 11.04 and 9.43 h) compared with the plain burger (5.04 h). Both oils are also characterized by a potent radical scavenging activity in ABTS test (IC(50) values of 1.43 and 2.05 μg/ml for cinnamon and clove, respectively). In the α-amylase inhibitory assay, cumin and grape fruits were the most potent with IC(50) values of 21.88 and 23.95 μg/ml, respectively. PMID:25265207

  7. The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus.

    PubMed

    Dai, Xinghong; Yu, Xuekui; Gong, Hao; Jiang, Xiaohong; Abenes, Gerrado; Liu, Hongrong; Shivakoti, Sakar; Britt, William J; Zhu, Hua; Liu, Fenyong; Zhou, Z Hong

    2013-08-01

    Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes birth defects in newborns and life-threatening complications in immunocompromised individuals. Among all human herpesviruses, HCMV contains a much larger dsDNA genome within a similarly-sized capsid compared to the others, and it was proposed to require pp150, a tegument protein only found in cytomegaloviruses, to stabilize its genome-containing capsid. However, little is known about how pp150 interacts with the underlying capsid. Moreover, the smallest capsid protein (SCP), while dispensable in herpes simplex virus type 1, was shown to play essential, yet undefined, role in HCMV infection. Here, by cryo electron microscopy (cryoEM), we determine three-dimensional structures of HCMV capsid (no pp150) and virion (with pp150) at sub-nanometer resolution. Comparison of these two structures reveals that each pp150 tegument density is composed of two helix bundles connected by a long central helix. Correlation between the resolved helices and sequence-based secondary structure prediction maps the tegument density to the N-terminal half of pp150. The structures also show that SCP mediates interactions between the capsid and pp150 at the upper helix bundle of pp150. Consistent with this structural observation, ribozyme inhibition of SCP expression in HCMV-infected cells impairs the formation of DNA-containing viral particles and reduces viral yield by 10,000 fold. By cryoEM reconstruction of the resulting "SCP-deficient" viral particles, we further demonstrate that SCP is required for pp150 functionally binding to the capsid. Together, our structural and biochemical results point to a mechanism whereby SCP recruits pp150 to stabilize genome-containing capsid for the production of infectious HCMV virion. PMID:23966856

  8. Iron-sulfur cluster N7 of the NADH:ubiquinone oxidoreductase (complex I) is essential for stability but not involved in electron transfer.

    PubMed

    Pohl, Thomas; Bauer, Theresa; Drner, Katerina; Stolpe, Stefan; Sell, Philipp; Zocher, Georg; Friedrich, Thorsten

    2007-06-01

    The NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli is composed of 13 subunits called NuoA through NuoN. It catalyzes the electron transfer from NADH to ubiquinone by a chain of redox groups consisting of one FMN and seven iron-sulfur clusters. The function of the additional, nonconserved cluster N7 located on NuoG is not known. It has been speculated that it is not involved in electron transfer, due to its distance of more than 20 A from the electron transfer chain. Dithionite-reduced minus NADH-reduced EPR difference spectra of complex I and of a soluble fragment containing NuoG revealed for the first time the EPR spectrum of N7 in the complex. Individual mutation of the cysteines ligating this cluster to alanine led to a decreased amount of complex I in the membrane without affecting the electron transfer activity. Sucrose gradient centrifugation revealed that the complex from the C230A and C233A mutants decayed in detergent solution while the C237A and C265A mutant complex was stable. Cluster N7 was detectable in the latter mutants but with shifted g-values, indicating a different ligation of N7. Thus, N7 is essential for the stability of the complex but is not involved in electron transfer. PMID:17489563

  9. Renewal of radiological equipment.

    PubMed

    2014-10-01

    In this century, medical imaging is at the heart of medical practice. Besides providing fast and accurate diagnosis, advances in radiology equipment offer new and previously non-existing options for treatment guidance with quite low morbidity, resulting in the improvement of health outcomes and quality of life for the patients. Although rapid technological development created new medical imaging modalities and methods, the same progress speed resulted in accelerated technical and functional obsolescence of the same medical imaging equipment, consequently creating a need for renewal. Older equipment has a high risk of failures and breakdowns, which might cause delays in diagnosis and treatment of the patient, and safety problems both for the patient and the medical staff. The European Society of Radiology is promoting the use of up-to-date equipment, especially in the context of the EuroSafe Imaging Campaign, as the use of up-to-date equipment will improve quality and safety in medical imaging. Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or renewal. This plan should look forward a minimum of 5 years, with annual updates. Teaching points Radiological equipment has a definite life cycle span, resulting in unavoidable breakdown and decrease or loss of image quality which renders equipment useless after a certain time period. Equipment older than 10 years is no longer state-of-the art equipment and replacement is essential. Operating costs of older equipment will be high when compared with new equipment, and sometimes maintenance will be impossible if no spare parts are available. Older equipment has a high risk of failure and breakdown, causing delays in diagnosis and treatment of the patient and safety problems both for the patient and the medical staff. Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or replacement. This plan should look forward a minimum of 5 years, with annual updating. PMID:25230589

  10. Essential Tremor

    MedlinePLUS

    ... for essential tremor. Symptomatic drug therapy may include propranolol or other beta blockers and primidone, an anticonvulsant drug. Eliminating tremor "triggers" such as caffeine and other stimulants from ...

  11. Thin, a Trim32 ortholog, is essential for myofibril stability and is required for the integrity of the costamere in Drosophila

    PubMed Central

    LaBeau-DiMenna, Elisa M.; Clark, Kathleen A.; Bauman, Kenneth D.; Parker, Daniel S.; Cripps, Richard M.; Geisbrecht, Erika R.

    2012-01-01

    Myofibril stability is required for normal muscle function and maintenance. Mutations that disrupt myofibril stability result in individuals who develop progressive muscle wasting, or muscular dystrophy, and premature mortality. Here we present our investigations of the Drosophila l(2)thin [l(2)tn] mutant. The thin phenotype exhibits features of the human muscular disease phenotype in that tn mutant larvae show progressive muscular degeneration. Loss-of-function and rescue experiments determined that l(2)tn is allelic to the tn locus [previously annotated as both CG15105 and another b-box affiliate (abba)]. tn encodes a TRIM (tripartite motif) containing protein highly expressed in skeletal muscle and is orthologous to the human limb-girdle muscular dystrophy type 2H disease gene Trim32. Thin protein is localized at the Z-disk in muscle, but l(2)tn mutants showed no genetic interaction with mutants affecting the Z-lineassociated protein muscle LIM protein 84B. l(2)tn, along with loss-of-function mutants generated for tn, showed no relative mislocalization of the Z-disk proteins ?-Actinin and muscle LIM protein 84B. In contrast, tn mutants had significant disorganization of the costameric orthologs ?-integrin, Spectrin, Talin, and Vinculin, and we present the initial description for the costamere, a key muscle stability complex, in Drosophila. Our studies demonstrate that myofibrils progressively unbundle in flies that lack Thin function through progressive costamere breakdown. Due to the high conservation of these structures in animals, we demonstrate a previously unknown role for TRIM32 proteins in myofibril stability. PMID:23071324

  12. A comparison of intraoral antimicrobial effects of stabilized stannous fluoride dentifrice, baking soda/peroxide dentifrice, conventional NaF dentifrice and essential oil mouthrinse.

    PubMed

    Bacca, L A; Leusch, M; Lanzalaco, A C; Macksood, D; Bouwsma, O J; Shaffer, J B; Howard-Nordan, K S; Knippenberg, S H; Kreutzjans, M K; Miller, J M; Poore, C L; Sunberg, R J; Vastola, K A; Becus, M; Bartizek, R D; Block, R P; Briner, W W; White, D J

    1997-01-01

    The intraoral antimicrobial activity of four commercial oral products-conventional NaF dentifrice (Crest), baking soda/peroxide/NaF dentifrice (Mentadent), essential oil mouthrinse (Listerine) and SnF2 dentifrice (Crest Plus Gum Care)-have been compared in three test regimens. Formulations were compared for their ability to suppress the regrowth and apical extension of dental plaque following toothbrushing during thirty hours of non-brushing where products were used as oral rinses (30-hour plaque regrowth model). Formulations were also compared for their ability to suppress the colony-forming units (cfu) of facultative anaerobic bacteria sampled from buccal gingival surfaces following use (Gingival Surface Microbial Index-GSMI model). Lastly, formulations were compared for effects in suppressing the glycolytic metabolic activity and regrowth activity of in vivo-treated dental plaques sampled at various periods following topical use and incubated under controlled ex vivo conditions (Plaque Glycolysis and Regrowth-PGRM model). In thirty-hour plaque regrowth testing, the rank ordered antimicrobial efficacy of formulations followed SnF2 > essential oils > NaF = water = baking soda/peroxide. In GSMI testing, all formulations were shown to suppress the cfu of facultative anaerobic bacteria relative to baseline, although SnF2 treatment was observed to reduce bacterial levels to a significantly greater degree than NaF dentifrice or baking soda/peroxide dentifrice up to two hours following brushing. In PGRM testing, the SnF2 dentifrice provided significant inhibition of bacterial metabolism and regrowth following topical application when compared with the NaF dentifrice as control. The baking soda/peroxide dentifrice provided no reduction in either bacterial metabolism or regrowth in PGRM. Previous studies had demonstrated modest effects for essential oil rinse in reducing PGRM plaque regrowth, with no effects for this treatment on plaque metabolism. Overall, these results demonstrate that SnF2 dentifrice provides substantial intraoral antimicrobial effects. The essential oil mouthrinse also exhibits significant intraoral antimicrobial effects, albeit apparently less than SnF2 dentifrice. The baking soda/peroxide dentifrice did not produce any antimicrobial effects following in vivo use compared with conventional dentifrice. These results provide mechanistic rationale for the chemotherapeutic efficacy of SnF2 and essential oil formulations in reducing gingivitis, while providing no support for the expectation of clinical efficacy for formulations containing baking soda and peroxide. PMID:9238874

  13. USGS Equipment

    USGS Multimedia Gallery

    USGS traveling equipment above Minot, North Dakota. USGS personnel were measuring the streamflow of the Souris River above Minot, NDon June 24, 2011.Streamflow was approximately 20,800 cubic feet per second, stage approximately 23.46 feet....

  14. Telescope Equipment

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Renaissance Telescope for high resolution and visual astronomy has five 82-degree Field Tele-Vue Nagler Eyepieces, some of the accessories that contribute to high image quality. Telescopes and eyepieces are representative of a family of optical equipment manufactured by Tele-Vue Optics, Inc.

  15. Arabidopsis BRICK1/HSPC300 is an essential WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2.

    PubMed

    Le, Jie; Mallery, Eileen L; Zhang, Chunhua; Brankle, Steven; Szymanski, Daniel B

    2006-05-01

    The actin cytoskeleton dynamically reorganizes the cytoplasm during cell morphogenesis. The actin-related protein (Arp)2/3 complex is a potent nucleator of actin filaments that controls a variety of endomembrane functions including the endocytic internalization of plasma membrane , vacuole biogenesis , plasma-membrane protrusion in crawling cells , and membrane trafficking from the Golgi . Therefore, Arp2/3 is an important signaling target during morphogenesis. The evolutionarily conserved Rac-WAVE-Arp2/3 pathway links actin filament nucleation to cell morphogenesis . WAVE translates Rac-GTP signals into Arp2/3 activation by regulating the stability and/or localization of the activator subunit Scar/WAVE . The WAVE complex includes Sra1/PIR121/CYFIP1, Nap1/NAP125, Abi-1/Abi-2, Brick1(Brk1)/HSPC300, and Scar/WAVE : Defining the in vivo function of each subunit is an important step toward understanding this complicated signaling pathway. Brk1/HSPC300 has been the most recalcitrant WAVE-complex protein and has no known function. In this paper, we report that Arabidopsis brick1 (brk1) is a member of the "distorted group" of trichome morphology mutants, a group that defines a WAVE-ARP2/3 morphogenesis pathway . In this paper we provide the first strong genetic and biochemical evidence that BRK1 is a critical WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2. PMID:16584883

  16. Suitable features selection for monitoring thermal condition of electrical equipment using infrared thermography

    NASA Astrophysics Data System (ADS)

    Huda, A. S. N.; Taib, S.

    2013-11-01

    Monitoring the thermal condition of electrical equipment is necessary for maintaining the reliability of electrical system. The degradation of electrical equipment can cause excessive overheating, which can lead to the eventual failure of the equipment. Additionally, failure of equipment requires a lot of maintenance cost, manpower and can also be catastrophic- causing injuries or even deaths. Therefore, the recognition processof equipment conditions as normal and defective is an essential step towards maintaining reliability and stability of the system. The study introduces infrared thermography based condition monitoring of electrical equipment. Manual analysis of thermal image for detecting defects and classifying the status of equipment take a lot of time, efforts and can also lead to incorrect diagnosis results. An intelligent system that can separate the equipment automatically could help to overcome these problems. This paper discusses an intelligent classification system for the conditions of equipment using neural networks. Three sets of features namely first order histogram based statistical, grey level co-occurrence matrix and component based intensity features are extracted by image analysis, which are used as input data for the neural networks. The multilayered perceptron networks are trained using four different training algorithms namely Resilient back propagation, Bayesian Regulazation, Levenberg-Marquardt and Scale conjugate gradient. The experimental results show that the component based intensity features perform better compared to other two sets of features. Finally, after selecting the best features, multilayered perceptron network trained using Levenberg-Marquardt algorithm achieved the best results to classify the conditions of electrical equipment.

  17. Efficiency of vanilla, patchouli and ylang ylang essential oils stabilized by iron oxide@C14 nanostructures against bacterial adherence and biofilms formed by Staphylococcus aureus and Klebsiella pneumoniae clinical strains.

    PubMed

    Bilcu, Maxim; Grumezescu, Alexandru Mihai; Oprea, Alexandra Elena; Popescu, Roxana Cristina; Mogo?anu, George Dan; Hristu, Radu; Stanciu, George A; Mihailescu, Dan Florin; Lazar, Veronica; Bezirtzoglou, Eugenia; Chifiriuc, Mariana Carmen

    2014-01-01

    Biofilms formed by bacterial cells are associated with drastically enhanced resistance against most antimicrobial agents, contributing to the persistence and chronicization of the microbial infections and to therapy failure. The purpose of this study was to combine the unique properties of magnetic nanoparticles with the antimicrobial activity of three essential oils to obtain novel nanobiosystems that could be used as coatings for catheter pieces with an improved resistance to Staphylococcus aureus and Klebsiella pneumoniae clinical strains adherence and biofilm development. The essential oils of ylang ylang, patchouli and vanilla were stabilized by the interaction with iron oxide@C14 nanoparticles to be further used as coating agents for medical surfaces. Iron oxide@C14 was prepared by co-precipitation of Fe+2 and Fe+3 and myristic acid (C14) in basic medium. Vanilla essential oil loaded nanoparticles pelliculised on the catheter samples surface strongly inhibited both the initial adherence of S. aureus cells (quantified at 24 h) and the development of the mature biofilm quantified at 48 h. Patchouli and ylang-ylang essential oils inhibited mostly the initial adherence phase of S. aureus biofilm development. In the case of K. pneumoniae, all tested nanosystems exhibited similar efficiency, being active mostly against the adherence K. pneumoniae cells to the tested catheter specimens. The new nanobiosystems based on vanilla, patchouli and ylang-ylang essential oils could be of a great interest for the biomedical field, opening new directions for the design of film-coated surfaces with anti-adherence and anti-biofilm properties. PMID:25375335

  18. Essential Questions

    ERIC Educational Resources Information Center

    Wilhelm, Jeffrey D.

    2012-01-01

    The secret to teaching may be as simple as asking students good questions--and then giving them the opportunity to find the answers. The author shares how he uses essential questions that set the class off on an inquiry. Rather than consuming information that he distributes and then repeating it on a test, students carry out their own…

  19. Research essentials.

    PubMed

    Chudleigh, Jane; Smith, Joanna

    2016-02-01

    IDENTIFYING a funding body is daunting in an increasingly competitive market. It is essential to consider whether you, your workplace and your project meet funding body objectives and application criteria. A comprehensive list of funding bodies can be found at the RCN website, at tinyurl.com/h74rg86. PMID:26856566

  20. Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans.

    PubMed

    Scott, Paul G; Dodd, Carole M; Bergmann, Ernst M; Sheehan, John K; Bishop, Paul N

    2006-05-12

    Biglycan and decorin are two closely related proteoglycans whose protein cores contain leucine-rich repeats flanked by disulfides. We have previously shown that decorin is dimeric both in solution and in crystal structures. In this study we determined whether biglycan dimerizes and investigated the role of dimerization in the folding and stability of these proteoglycans. We used light scattering to show that biglycan is dimeric in solution and solved the crystal structure of the glycoprotein core of biglycan at 3.40-angstroms resolution. This structure reveals that biglycan dimerizes in the same way as decorin, i.e. by apposition of the concave inner surfaces of the leucine-rich repeat domains. We demonstrate that low concentrations of guanidinium chloride denature biglycan and decorin but that the denaturation is completely reversible following removal of the guanidinium chloride, as assessed by circular dichroism spectroscopy. Furthermore, the rate of refolding is dependent on protein concentration, demonstrating that it is not a unimolecular process. Upon heating, decorin shows a single structural transition at a T(m) of 45-46 degrees C but refolds completely upon cooling to 25 degrees C. This property of decorin enabled us to show both by calorimetry and light scattering that dimer to monomer transition coincided with unfolding and monomer to dimer transition coincided with refolding; thus these processes are inextricably linked. We further conclude that folded monomeric biglycan or decorin cannot exist in solution. This implies novel interrelated functions for the parallel beta sheet faces of these leucine-rich repeat proteoglycans, including dimerization and stabilization of protein folding. PMID:16547006

  1. Histone Acetyl Transferase 1 Is Essential for Mammalian Development, Genome Stability, and the Processing of Newly Synthesized Histones H3 and H4

    PubMed Central

    Nagarajan, Prabakaran; Ge, Zhongqi; Sirbu, Bianca; Doughty, Cheryl; Agudelo Garcia, Paula A.; Schlederer, Michaela; Annunziato, Anthony T.; Cortez, David; Kenner, Lukas; Parthun, Mark R.

    2013-01-01

    Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the function of this enzyme in a complex organism, we have constructed a conditional mouse knockout model of Hat1. Murine Hat1 is essential for viability, as homozygous deletion of Hat1 results in neonatal lethality. The lungs of embryos and pups genetically deficient in Hat1 were much less mature upon histological evaluation. The neonatal lethality is due to severe defects in lung development that result in less aeration and respiratory distress. Many of the Hat1−/− neonates also display significant craniofacial defects with abnormalities in the bones of the skull and jaw. Hat1−/− mouse embryonic fibroblasts (MEFs) are defective in cell proliferation and are sensitive to DNA damaging agents. In addition, the Hat1−/− MEFs display a marked increase in genome instability. Analysis of histone dynamics at sites of replication-coupled chromatin assembly demonstrates that Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly. PMID:23754951

  2. An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin.

    PubMed

    Tange, Yoshie; Hirata, Aiko; Niwa, Osami

    2002-11-15

    We identified a novel fission yeast gene, ned1(+), with pleiotropic mutations that have a high incidence of chromosome missegregation, aberrantly shaped nuclei, overdeveloped endoplasmic reticulum-like membranes, and increased sensitivity to a microtubule destabilizing agent. Ned1 protein, which was phosphorylated in a growth-related manner, interacted in a yeast two-hybrid system with Dis3 as well as with Pim1/RCC1 (nucleotide exchange factor for Ran). Ned1 also interacted with an essential nucleoporin, a probable homologue of mammalian Nup98/96. The ned1 gene displayed a variety of genetic interactions with factors involved in nuclear transport and chromosome segregation, including the crm1 (exportin), spi1 (small GTPase Ran), pim1, and dis genes. A substitution mutation that affected the two-hybrid interaction with Dis3 increased chromosome instability, suggesting the functional importance of the interaction. Overproduction of Ned1 protein induced formation of an abnormal microtubule bundle within the nucleus, apparently independently of the spindle pole body, but dependent on pim1(+) activity. The ned1(+) gene belongs to an evolutionarily conserved gene family, which includes the mouse Lpin genes, one of whose mutations is responsible for lipodystrophy. PMID:12376568

  3. Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.

    PubMed

    Nagarajan, Prabakaran; Ge, Zhongqi; Sirbu, Bianca; Doughty, Cheryl; Agudelo Garcia, Paula A; Schlederer, Michaela; Annunziato, Anthony T; Cortez, David; Kenner, Lukas; Parthun, Mark R

    2013-06-01

    Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the function of this enzyme in a complex organism, we have constructed a conditional mouse knockout model of Hat1. Murine Hat1 is essential for viability, as homozygous deletion of Hat1 results in neonatal lethality. The lungs of embryos and pups genetically deficient in Hat1 were much less mature upon histological evaluation. The neonatal lethality is due to severe defects in lung development that result in less aeration and respiratory distress. Many of the Hat1(-/-) neonates also display significant craniofacial defects with abnormalities in the bones of the skull and jaw. Hat1(-/-) mouse embryonic fibroblasts (MEFs) are defective in cell proliferation and are sensitive to DNA damaging agents. In addition, the Hat1(-/-) MEFs display a marked increase in genome instability. Analysis of histone dynamics at sites of replication-coupled chromatin assembly demonstrates that Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly. PMID:23754951

  4. Essential tremor

    PubMed Central

    2007-01-01

    Introduction Essential tremor is one of the most common movement disorders throughout the world, with prevalence in the general population of 0.4% to 3.9%. Although most people with essential tremor are only mildly affected, those who seek medical care are disabled to some extent, and most are socially handicapped by the tremor. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical question: What are the effects of drug treatments in people with essential tremor of the hand? We searched: Medline, Embase, The Cochrane Library, and other important databases up to December 2006 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found 41 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. Conclusions In this systematic review, we present information relating to the effectiveness and safety of the following interventions: adding mirtazepine to other antitremor drugs; benzodiazepines; beta-blockers other than propranolol; botulinum A toxin-haemagglutinin complex; calcium channel blockers; carbonic anhydrase inhibitors; clonidine; flunarizine; gabapentin; isoniazid; Phenobarbital; primidone; propranolol; and topiramate. PMID:19454072

  5. The BEACH Domain Protein SPIRRIG Is Essential for Arabidopsis Salt Stress Tolerance and Functions as a Regulator of Transcript Stabilization and Localization

    PubMed Central

    Steffens, Alexandra; Bräutigam, Andrea; Jakoby, Marc; Hülskamp, Martin

    2015-01-01

    Members of the highly conserved class of BEACH domain containing proteins (BDCPs) have been established as broad facilitators of protein–protein interactions and membrane dynamics in the context of human diseases like albinism, bleeding diathesis, impaired cellular immunity, cancer predisposition, and neurological dysfunctions. Also, the Arabidopsis thaliana BDCP SPIRRIG (SPI) is important for membrane integrity, as spi mutants exhibit split vacuoles. In this work, we report a novel molecular function of the BDCP SPI in ribonucleoprotein particle formation. We show that SPI interacts with the P-body core component DECAPPING PROTEIN 1 (DCP1), associates to mRNA processing bodies (P-bodies), and regulates their assembly upon salt stress. The finding that spi mutants exhibit salt hypersensitivity suggests that the local function of SPI at P-bodies is of biological relevance. Transcriptome-wide analysis revealed qualitative differences in the salt stress-regulated transcriptional response of Col-0 and spi. We show that SPI regulates the salt stress-dependent post-transcriptional stabilization, cytoplasmic agglomeration, and localization to P-bodies of a subset of salt stress-regulated mRNAs. Finally, we show that the PH-BEACH domains of SPI and its human homolog FAN (Factor Associated with Neutral sphingomyelinase activation) interact with DCP1 isoforms from plants, mammals, and yeast, suggesting the evolutionary conservation of an association of BDCPs and P-bodies. PMID:26133670

  6. Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.

    PubMed

    Tsunoda, Satoshi; Sakurai, Hiroaki; Saito, Yurika; Ueno, Yoko; Koizumi, Keiichi; Saiki, Ikuo

    2009-02-01

    Inflammation in the tumor stroma greatly influences tumor development. In the present study, we investigated the roles of fibroblast growth factor (FGF)-2-induced chronic inflammation in the development of 4T1 murine mammary tumors. Administration of FGF-2 into the tumor inoculation site during the initial phase of tumor growth enhanced tumor growth and pulmonary metastasis as well as microvessel density in tumor tissues in normal but not in nude mice. Infiltration of T lymphocytes and macrophages, recruitment of pericytes/vascular mural cells in neovascular walls, and the expression levels of cyclooxygenase (COX)-2 and vascular endothelial growth factor A (VEGFA) were also enhanced in the FGF-2-activated host stroma of normal mice. In addition, FGF-2-induced tumor growth and metastasis was abrogated by administration of either an immunosuppressant, FK506, or a COX-2 inhibitor. FGF-2 enhanced prostaglandin E(2) secretion in cultured T lymphocytes. In addition, VEGFA secretion was increased in a co-culture of T lymphocytes and fibroblasts in vitro. These results indicate that the massive infiltration of T lymphocytes into FGF-2-activated host stroma during the initial phase of tumor growth enhances neovascular stability by regulating endogenous COX-2 and VEGFA levels because both compounds are known to play important roles in marked 4T1 mammary tumor development via FGF-2-induced inflammatory reactions. PMID:19116363

  7. FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in Chlamydomonas.

    PubMed

    Yanagisawa, Haru-aki; Mathis, Garrison; Oda, Toshiyuki; Hirono, Masafumi; Richey, Elizabeth A; Ishikawa, Hiroaki; Marshall, Wallace F; Kikkawa, Masahide; Qin, Hongmin

    2014-05-01

    The axoneme-the conserved core of eukaryotic cilia and flagella-contains highly specialized doublet microtubules (DMTs). A long-standing question is what protein(s) compose the junctions between two tubules in DMT. Here we identify a highly conserved flagellar-associated protein (FAP), FAP20, as an inner junction (IJ) component. The flagella of Chlamydomonas FAP20 mutants have normal length but beat with an abnormal symmetrical three-dimensional pattern. In addition, the mutant axonemes are liable to disintegrate during beating, implying that interdoublet connections may be weakened. Conventional electron microscopy shows that the mutant axonemes lack the IJ, and cryo-electron tomography combined with a structural labeling method reveals that the labeled FAP20 localizes at the IJ. The mutant axonemes also lack doublet-specific beak structures, which are localized in the proximal portion of the axoneme and may be involved in planar asymmetric flagellar bending. FAP20 itself, however, may not be a beak component, because uniform localization of FAP20 along the entire length of all nine DMTs is inconsistent with the beak's localization. FAP20 is the first confirmed component of the IJ. Our data also suggest that the IJ is important for both stabilizing the axoneme and scaffolding intra-B-tubular substructures required for a planar asymmetrical waveform. PMID:24574454

  8. FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in Chlamydomonas

    PubMed Central

    Yanagisawa, Haru-aki; Mathis, Garrison; Oda, Toshiyuki; Hirono, Masafumi; Richey, Elizabeth A.; Ishikawa, Hiroaki; Marshall, Wallace F.; Kikkawa, Masahide; Qin, Hongmin

    2014-01-01

    The axonemethe conserved core of eukaryotic cilia and flagellacontains highly specialized doublet microtubules (DMTs). A long-standing question is what protein(s) compose the junctions between two tubules in DMT. Here we identify a highly conserved flagellar-associated protein (FAP), FAP20, as an inner junction (IJ) component. The flagella of Chlamydomonas FAP20 mutants have normal length but beat with an abnormal symmetrical three-dimensional pattern. In addition, the mutant axonemes are liable to disintegrate during beating, implying that interdoublet connections may be weakened. Conventional electron microscopy shows that the mutant axonemes lack the IJ, and cryoelectron tomography combined with a structural labeling method reveals that the labeled FAP20 localizes at the IJ. The mutant axonemes also lack doublet-specific beak structures, which are localized in the proximal portion of the axoneme and may be involved in planar asymmetric flagellar bending. FAP20 itself, however, may not be a beak component, because uniform localization of FAP20 along the entire length of all nine DMTs is inconsistent with the beak's localization. FAP20 is the first confirmed component of the IJ. Our data also suggest that the IJ is important for both stabilizing the axoneme and scaffolding intraB-tubular substructures required for a planar asymmetrical waveform. PMID:24574454

  9. Essential tremor.

    PubMed Central

    Murray, T. J.

    1981-01-01

    Essential tremor, including the juvenile and senile variations, may be a result of a disorder of the servomechanism that controls physiologic tremor. Hands and arms are affected most commonly, and the tremor can vary in amplitude as well as frequency. Long-term treatment with propranolol has been helpful for some patients, although older patients are less likely to benefit. Other drugs and behaviour modification therapy have been less successful. Surgical treatment is effective but should probably be reserved for severe cases. An effective instrument for measuring the subjective and objective aspects of the tremor is still needed, as is an effective long-term method of treatment. PMID:7018658

  10. Tim62, a Novel Mitochondrial Protein in Trypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex.

    PubMed

    Singha, Ujjal K; Hamilton, VaNae; Chaudhuri, Minu

    2015-09-18

    Trypanosoma brucei, the causative agent of human African trypanosomiasis, possesses non-canonical mitochondrial protein import machinery. Previously, we characterized the essential translocase of the mitochondrial inner membrane (TIM) consisting of Tim17 in T. brucei. TbTim17 is associated with TbTim62. Here we show that TbTim62, a novel protein, is localized in the mitochondrial inner membrane, and its import into mitochondria depends on TbTim17. Knockdown (KD) of TbTim62 decreased the steady-state levels of TbTim17 post-transcriptionally. Further analysis showed that import of TbTim17 into mitochondria was not inhibited, but its half-life was reduced >4-fold due to TbTim62 KD. Blue-native gel electrophoresis revealed that TbTim62 is present primarily in ?150-kDa and also in ?1100-kDa protein complexes, whereas TbTim17 is present in multiple complexes within the range of ?300 to ?1100 kDa. TbTim62 KD reduced the levels of both TbTim62 as well as TbTim17 protein complexes. Interestingly, TbTim17 was accumulated as lower molecular mass complexes in TbTim62 KD mitochondria. Furthermore, depletion of TbTim62 hampered the assembly of the ectopically expressed TbTim17-2X-myc into TbTim17 protein complex. Co-immunoprecipitation analysis revealed that association of TbTim17 with mHSP70 was markedly reduced in TbTim62 KD mitochondria. All together our results demonstrate that TbTim62, a unique mitochondrial protein in T. brucei, is required for the formation of a stable TbTim17 protein complex. TbTim62 KD destabilizes this complex, and unassembled TbTim17 degrades. Therefore, TbTim62 acts as a novel regulatory factor to maintain the levels of TIM in T. brucei mitochondria. PMID:26240144

  11. 47 CFR 18.211 - Multiple listing of equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Multiple listing of equipment. 18.211 Section 18.211 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INDUSTRIAL, SCIENTIFIC, AND MEDICAL EQUIPMENT Applications and Authorizations § 18.211 Multiple listing of equipment. (a) When the same or essentially the same equipment will...

  12. Essential Supersymmetry

    NASA Astrophysics Data System (ADS)

    Polonsky, Nir

    2000-07-01

    Theoretical and experimental motivations, status and prospects of low-energy supersymmetry are discussed. It is shown by explicit construction that the stabilization of any perturbative theory which contains fundamental scalar bosons naturally leads to the notion of supersymmetry. The supersymmetric algebra is briefly described and the resulting constraints on the low-energy theory are emphasized. The minimal supersymmetric extension of the standard model is then pedagogically defined and discussed, and its experimental status is summarized. Dimensionless couplings are extrapolated to high energies and the unification scale is found and interpreted. Renormalization of the models is discussed and the linkage between high and low energies is demonstrated and argued to provide a potential probe of Planck scale physics. Electroweak symmetry breaking is shown to occur dynamically and to successfully predict a heavy t-quark. The low-energy Higgs potential is discussed more generally and special attention is given to the lightest Higgs boson. The upper bound on its mass in minimal and extended models is reviewed and explained. The Higgs mass is shown to provide a crucial test of nearly all supersymmetric theories. Generic low-energy flavor violations (the so-called flavor problem) are described and are used to constrain and classify consistent high-energy models for the s-particle spectrum parameters which softly break supersymmetry at low-energies. Generation of these parameters via tree-level local-supersymmetry interactions (supergravity mediation) or gauge quantum corrections (gauge mediation) is outlined. Possible lepton-number violation and scenarios for neutrino mass generation are also described.

  13. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... that it does not cause essential loads to become inoperative as a result of electrical power supply... electronic equipment must be supplied with power under the requirements of § 25.1355(c). (c) Radio...

  14. Essential thrombocythemia

    PubMed Central

    Brire, Jean B

    2007-01-01

    Essential thrombocythemia (ET) is an acquired myeloproliferative disorder (MPD) characterized by a sustained elevation of platelet number with a tendency for thrombosis and hemorrhage. The prevalence in the general population is approximately 30/100,000. The median age at diagnosis is 65 to 70 years, but the disease may occur at any age. The female to male ratio is about 2:1. The clinical picture is dominated by a predisposition to vascular occlusive events (involving the cerebrovascular, coronary and peripheral circulation) and hemorrhages. Some patients with ET are asymptomatic, others may experience vasomotor (headaches, visual disturbances, lightheadedness, atypical chest pain, distal paresthesias, erythromelalgia), thrombotic, or hemorrhagic disturbances. Arterial and venous thromboses, as well as platelet-mediated transient occlusions of the microcirculation and bleeding, represent the main risks for ET patients. Thromboses of large arteries represent a major cause of mortality associated with ET or can induce severe neurological, cardiac or peripheral artery manifestations. Acute leukemia or myelodysplasia represent only rare and frequently later-onset events. The molecular pathogenesis of ET, which leads to the overproduction of mature blood cells, is similar to that found in other clonal MPDs such as chronic myeloid leukemia, polycythemia vera and myelofibrosis with myeloid metaplasia of the spleen. Polycythemia vera, myelofibrosis with myeloid metaplasia of the spleen and ET are generally associated under the common denomination of Philadelphia (Ph)-negative MPDs. Despite the recent identification of the JAK2 V617F mutation in a subset of patients with Ph-negative MPDs, the detailed pathogenetic mechanism is still a matter of discussion. Therapeutic interventions in ET are limited to decisions concerning the introduction of anti-aggregation therapy and/or starting platelet cytoreduction. The therapeutic value of hydroxycarbamide and aspirin in high risk patients has been supported by controlled studies. Avoiding thromboreduction or opting for anagrelide to postpone the long-term side effects of hydrocarbamide in young or low risk patients represent alternative options. Life expectancy is almost normal and similar to that of a healthy population matched by age and sex. PMID:17210076

  15. Aquatic Equipment Information.

    ERIC Educational Resources Information Center

    Sova, Ruth

    Equipment usually used in water exercise programs is designed for variety, intensity, and program necessity. This guide discusses aquatic equipment under the following headings: (1) equipment design; (2) equipment principles; (3) precautions and contraindications; (4) population contraindications; and (5) choosing equipment. Equipment is used…

  16. Personal protective equipment

    MedlinePLUS

    Personal protective equipment (PPE) is special equipment you wear to create a barrier between you and germs. ... Centers for Disease Control and Prevention. Personal protective equipment. http://www.cdc.gov/niosh/ppe. Accessed February 20, 2014.

  17. Gene expression of heat shock protein 70 and antioxidant enzymes, oxidative status, and meat oxidative stability of cyclically heat-challenged finishing broilers fed Origanum compactum and Curcuma xanthorrhiza essential oils.

    PubMed

    Akbarian, A; Michiels, J; Golian, A; Buyse, J; Wang, Y; De Smet, S

    2014-08-01

    Heat stress in poultry is a serious problem in many countries and has been associated with oxidative stress. Hence, nutritional interventions with antioxidants might be beneficial. Therefore, the effects of dietary Curcuma xanthorrhiza (CX) and Origanum compactum (OC) essential oils on mRNA levels of heat shock protein 70 and antioxidant enzymes, oxidative status, and meat oxidative stability of heat-challenged broilers were studied. Starting on d 25 of age, a control diet and 4 diets containing 200 or 400 mg/kg feed of CX or OC (CX200, CX400, OC200, OC400 diets) were fed to 3 pen replicates of 20 Ross 308 chickens each. From d 28 of age on, the temperature was increased from 22 to 34°C with 50% RH for 5 h daily during 2 wk. Dietary CX or OC did not affect zootechnical performance. Feeding CX400 and both levels of OC increased the a* value in stored breast meat (P < 0.05), and OC diets tended to decrease the thiobarbituric acid reactive substances values in fresh breast meat (P = 0.061). Compared with control, at d 31, feeding CX400 and OC400 reduced mRNA levels of heat shock protein 70 and increased mRNA levels of catalase in kidney and liver (P < 0.05). The mRNA levels of superoxide dismutase were increased at d 31 on the OC400 diet in kidney and on the CX400 diet in heart (P < 0.05). In heart, at d 31, both dietary levels of CX and OC200 resulted in higher glutathione peroxidase activity (P < 0.05). Feeding CX400 increased superoxide dismutase activity in liver, kidney, and heart at d 31 (P < 0.05). Catalase activity was increased in the CX200 and OC400 groups at d 42 (P < 0.05). Feeding CX at both levels and OC200 decreased plasma malondialdehyde concentrations at d 42 (P < 0.05). In conclusion, dietary essential oils rich in simple phenolic compounds offer potential for improving the antioxidant defense against heat stress-induced changes. PMID:24931966

  18. Schools Lack the Equipment to Carry out Essential Practical Science

    ERIC Educational Resources Information Center

    Education in Science, 2013

    2013-01-01

    SCORE is a collaboration of organisations that aim to improve science education in UK schools and colleges by supporting the development and implementation of effective education policy. Research commissioned by SCORE (Science Community Representing Education), a collaboration including the Association for Science Education (ASE), reports that

  19. NaStEP: A Proteinase Inhibitor Essential to Self-Incompatibility and a Positive Regulator of HT-B Stability in Nicotiana alata Pollen Tubes1[W][OA

    PubMed Central

    Jimnez-Durn, Karina; McClure, Bruce; Garca-Campusano, Florencia; Rodrguez-Sotres, Rogelio; Cisneros, Jess; Busot, Grethel; Cruz-Garca, Felipe

    2013-01-01

    In Solanaceae, the self-incompatibility S-RNase and S-locus F-box interactions define self-pollen recognition and rejection in an S-specific manner. This interaction triggers a cascade of events involving other gene products unlinked to the S-locus that are crucial to the self-incompatibility response. To date, two essential pistil-modifier genes, 120K and High Top-Band (HT-B), have been identified in Nicotiana species. However, biochemistry and genetics indicate that additional modifier genes are required. We recently reported a Kunitz-type proteinase inhibitor, named NaStEP (for Nicotiana alata Stigma-Expressed Protein), that is highly expressed in the stigmas of self-incompatible Nicotiana species. Here, we report the proteinase inhibitor activity of NaStEP. NaStEP is taken up by both compatible and incompatible pollen tubes, but its suppression in Nicotiana spp. transgenic plants disrupts S-specific pollen rejection; therefore, NaStEP is a novel pistil-modifier gene. Furthermore, HT-B levels within the pollen tubes are reduced when NaStEP-suppressed pistils are pollinated with either compatible or incompatible pollen. In wild-type self-incompatible N. alata, in contrast, HT-B degradation occurs preferentially in compatible pollinations. Taken together, these data show that the presence of NaStEP is required for the stability of HT-B inside pollen tubes during the rejection response, but the underlying mechanism is currently unknown. PMID:23150644

  20. [Antioxidant properties of essential oils].

    PubMed

    Misharina, T A; Terenina, M B; Krikunova, N I

    2009-01-01

    By the method of capillary gas-liquid chromatography we studied antioxidant properties and stability during the storage of hexane solutions of 14 individual essential oils from black and white pepper (Piper nigrum L.), cardamom (Elettaria cardamomum L.), nutmeg (Myristica fragrans Houtt.), mace (Myristica fragrans Houtt), juniperberry (Juniperus communis L.), seed of fennel (Foeniculum vulgare Mill., var. dulce Thelling), caraway (Carvum carvi L.), dry leaves of cinnamon (Cinnamomum zeylanicum Bl.), marjoram (Origanum majorana L.), laurel (Laurus nobilis L.), ginger (Zingiber officinale L.), garlic (Allium sativum L.), and clove bud (Caryophyllus aromaticus L.). We assessed the antioxidant properties by the oxidation of aliphatic aldehyde (trans-2-hexenal) into the according carbon acid. We established that essential oils of garlic, clove bud, ginger and leaves of cinnamon have the maximal efficiency of inhibition of hexenal oxidation (80-93%), while black pepper oil has the minimal (49%). Antioxidant properties of essential oils with a high content of substituted phenols depended poorly on its concentration in model systems. We studied the changes in essential oils content during the storage of its hexane solutions for 40 days in the light and out of the light and compared it with the stability of essential oils stored for a year out of the light. PMID:20067158

  1. Maintenance program guidelines for programmatic equipment

    SciTech Connect

    Not Available

    1994-11-01

    The Division Directors at Lawrence Berkeley Laboratory are responsible for implementing a maintenance program for research equipment (also referred to as programmatic equipment) assigned to them. The program must allow maintenance to be accomplished in a manner that promotes operational safety, environmental protection and compliance, and cost effectiveness; that preserves the intended functions of the facilities and equipment; and that supports the programmatic mission of the Laboratory. Programmatic equipment -- such as accelerators, lasers, radiation detection equipment, and glove boxes -- is dedicated specifically to research. Installed equipment, by contrast, includes the mechanical and electrical systems installed as part of basic building construction, equipment essential to the normal functioning of the facility and its intended use. Examples of installed equipment are heating, ventilating, and air conditioning systems; elevators; and communications systems. The LBL Operating and Assurance Program Plan (PUB-3111, Revision 4) requires that a maintenance program be prepared for programmatic equipment and defines the basic maintenance program elements. Such a program of regular, documented maintenance is vital to the safety and quality of research activities. As a part of that support, this document offers guidance to Laboratory organizations for developing their maintenance programs. It clarifies the maintenance requirements of the Operating and Assurance Program (OAP) and presents an approach that, while not the only possibility, can be expected to produce an effective maintenance program for research equipment belonging to the Laboratory`s organizations.

  2. Design research of the operation stability in the regime with steam condensation of the emergency cooling heat exchanger of a nuclear power station equipped with the V-392 reactor installation

    NASA Astrophysics Data System (ADS)

    Budnikov, V. I.; Savikhin, O. G.; Chistov, A. S.; Fal'Kovskii, L. N.; Filimonov, Yu. V.; Berlyaev, P. V.

    2007-05-01

    The procedure of a calculation and analytical study of the condensing channel stability and the results of calculations of stability of the emergency-cooling heat exchanger of the Kudankulam nuclear power station (India) during its operation in a regime with steam condensation are presented.

  3. Water-Using Equipment: Commercial and Industrial

    SciTech Connect

    Solana, Amy E.; Mcmordie, Katherine

    2006-01-24

    Water is an important aspect of many facets in energy engineering. While the previous article detailed domestic related water-using equipment such as toilets and showerheads, this article focuses on various types of water-using equipment in commercial and industrial facilities, including commercial dishwashers and laundry, single-pass cooling equipment, boilers and steam generators, cooling towers, and landscape irrigation. Opportunities for water and energy conservation are explained, including both technology retrofits and operation and maintenance changes. Water management planning and leak detection are also included as they are essential to a successful water management program.

  4. Drawing evaluation report for sampling equipment drawings

    SciTech Connect

    WILSON, G.W.

    1999-05-24

    This document presents the results of a task to evaluate Tank Waste Remediation System (TWRS) sampling equipment drawings and identifies drawings category as either essential, support, or general drawings. This report completes the drawing evaluation task as outlined in Engineering Task Plan For Truck 3 and 4 Drawing Compliance and Evaluation (Wilson, 1997). The scope of this report is limited to an evaluation and identification of drawing category for drawings of certain tank waste sampling equipment for which the TRWS Characterization Project has been assigned custody, including: vapor sampling, grab sampling, auger sampling, and all core sampling equipment (see LMHC Task Order 304). This report does not address drawings for other waste tank deployed equipment systems having similar assigned custody, such as, Light Duty Utility Arm (LDUA), Cone Penetrometer system, or Long Length Contaminated Equipment (LLCE). The LDUA drawings are addressed in the Characterization Equipment Essential Drawings (HNF 1998). The Cone Penetrometer system drawings which are vendor drawings (not H- series) is not currently turned over to operations for deployment. The LLCE equipment was just recently assigned to Characterization Project and were not included in the original scope for this evaluation and will be addressed in the evaluation update scheduled for fiscal year 1999.

  5. Microform Retrieval Equipment Guide.

    ERIC Educational Resources Information Center

    National Archives and Records Service (GSA), Washington, DC. Office of Records Management.

    A basis for comparing available equipment against the requirements of the prospective user or purchaser of microform retrieval equipment is provided. As used in the handbook, microform retrieval equipment is defined as any device that is used to locate, enlarge, and display microform images or that produces enlarged hard copy from the images. Only

  6. Mobile Equipment Expands Inventory.

    ERIC Educational Resources Information Center

    McGough, Robert L.; And Others

    1978-01-01

    Describes the Mobile Equipment Modules (MEM) system in Duluth, Minnesota. MEM is a way to hold down costs and increase learning opportunities by consolidating purchases of expensive shop equipment within the school district, grouping the equipment in modules, and scheduling and moving it from school to school as needed. (MF)

  7. Essential Laboratory Activities Guide. Secondary Science.

    ERIC Educational Resources Information Center

    Duval County Schools, Jacksonville, FL.

    This teacher's guide was developed for use in junior and senior high schools in Duval County, Jacksonville, Florida, for the purpose of identifying those secondary science laboratory experiences which are essential to the development of science content knowledge and competency in handling science laboratory equipment and consumables. The guide

  8. Central Waste Complex (CWC) Safety Equipment List

    SciTech Connect

    WHITLOCK, R.W.

    2000-01-20

    This document lists all safety equipment for the Central Waste Complex, per HNF-PRO-704. This document provides a list of structures, systems, and components that are essential to the continuing safe operation of the Central Waste Complex, as designated by the applicable facility management and the cognizant engineer.

  9. RETRIEVAL EQUIPMENT DESCRIPTIONS

    SciTech Connect

    J. Steinhoff

    1997-08-25

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) retrieval from the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. There are no quality assurance requirements or QA controls in this document. Retrieval under normal conditions is accomplished with the same fleet of equipment as is used for emplacement. Descriptions of equipment used for retrieval under normal conditions is found in Emplacement Equipment Descriptions, DI: BCAF00000-01717-5705-00002 (a document in progress). Equipment used for retrieval under abnormal conditions is addressed in this document and consists of the following: (1) Inclined Plane Hauler; (2) Bottom Lift Transporter; (3) Load Haul Dump (LHD) Loader; (4) Heavy Duty Forklift for Emplacement Drifts; (5) Covered Shuttle Car; (6) Multipurpose Vehicle; and (7) Scaler.

  10. Shoulder rehabilitation: equipment - - modifications.

    PubMed

    Einhorn, A R

    1985-01-01

    A systematic approach toward weight-training equipment is needed in the physical therapy clinic and in establishing guidelines for the home program. Many different types of exercise equipment are currently being used. With an aggressive patient population, the physical therapist should become familiar with the various types of equipment now available in many of the exercise centers. J Orthop Sports Phys Ther 1985;6(4):247-253. PMID:18802307

  11. Shipboard Electronic Equipments.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    Fundamentals of major electronic equipments on board ships are presented in this text prepared for naval officers in general. Basic radio principles are discussed in connection with various types of transmitters, receivers, antennas, couplers, transfer panels, remote-control units, frequency standard equipments, teletypewriters, and facsimile…

  12. Equipment & New Products.

    ERIC Educational Resources Information Center

    Poitras, Adrian W., Ed.

    1977-01-01

    Presents several new products and equipment for teaching college science courses such as laser optics bench, portable digital thermometer, solar energy furnaces and blackboard optics kit. A description of all equipment or products, cost, and addresses of manufacturers are also included. (HM)

  13. School optical equipment

    NASA Astrophysics Data System (ADS)

    Bilmes, G. M.; Bolognini, Nestor A.; Gallardo, Mario; Tocho, Jorge O.; Trivi, Marcelo; Aljanati, D.; Dicovskiy, E.; Propato, J. L.

    2001-08-01

    A school optical equipment has been designed and developed. It is the result from the cooperative activities of researchers and experts in didactic of the science. The equipment includes a handbook, experimental guides and proposals to be carried in the classroom.

  14. Engineer Equipment Mechanic.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    Developed as part of the Marine Corps Institute (MCI) correspondence training program, this course on engineer equipment mechanics is designed to advance the professional competence of privates through sergeants as equipment mechanics, Military Occupation Specialty 1341, and is adaptable for nonmilitary instruction. Introductory materials include…

  15. Adaptive Recreational Equipment.

    ERIC Educational Resources Information Center

    Schilling, Mary Lou, Ed.

    1983-01-01

    Designed for teachers interested in therapeutic recreation, the document lists sources of adaptive recreational equipment and their homemade counterparts. Brief descriptions for ordering or constructing recreational equipment for the visually impaired, poorly coordinated, physically impaired, and mentally retarded are given. Specific adaptations

  16. Troubleshooting rotating equipment

    SciTech Connect

    Wong, R.F. )

    1992-10-01

    This paper reports that equipment problems in a Peruvian refinery illustrate the process engineer's role as a troubleshooter. Examples show that rotating equipment problems can stem from mechanical or process factors and involve both inspection/maintenance specialists and process engineers.

  17. Technology Equipment Rooms.

    ERIC Educational Resources Information Center

    Day, C. William

    2001-01-01

    Examines telecommunications equipment room design features that allow for growth and can accommodate numerous equipment replacements and upgrades with minimal service disruption and with minimal cost. Considerations involving the central hub, power and lighting needs, air conditioning, and fire protection are discussed. (GR)

  18. Selecting WP Equipment.

    ERIC Educational Resources Information Center

    Casady, Mona J.

    1981-01-01

    Suggestions for schools considering the purchase of word processing equipment are presented. Procedures for selecting equipment include getting information on prices, servicing, warranties, training, speed of printing, and quality of output. Choices to make include brand vs. service, price vs. service, and variety vs. limitations of brands. (CT)

  19. Equipment Operator 1 & C.

    ERIC Educational Resources Information Center

    Naval Education and Training Program Development Center, Pensacola, FL.

    The Rate Training Manual and Nonresident Career Course (RTM/NRCC) form a self-study package to assist Navy Equipment Operators First and Chief in fulfilling the requirements of their rating. (Navy Equipment Operators First and Chief direct and coordinate efforts of individuals and crews in construction, earthmoving, roadbuilding, quarrying, and

  20. Drawing Evaluation Report for Sampling Equipment

    SciTech Connect

    BOGER, R.M.

    1999-09-09

    This document presents the results of a task to update the evaluation of River Protection Project (WP) sampling equipment drawings and updates the assigned drawings category as either essential, support, or general drawings. This report updates the drawing evaluation that was originally done per Engineering Task Plan For Truck 3 & 4 Drawing Compliance and Evaluation. The scope of this report is limited to updating the evaluation and identification of drawing category for drawings of certain tank waste sampling equipment for which the RPP Characterization Project has been assigned custody, including: vapor sampling, grab sampling, auger sampling, all core sampling equipment, and Light Duty Utility Arm (LDUA) (see LMHC contract No. 519, release 10). This report does not address drawings for other waste tank deployed equipment systems having similar assigned custody, such as, Cone Penetrometer system, or Long Length Contaminated Equipment (LLCE). The Cone Penetrometer system, which is depicted on vendor drawings, (not H- series), is not currently turned over to operations for deployment. The LLCE equipment was just recently assigned to Characterization Project and was not included in the original scope for this update and will be addressed in the evaluation update scheduled for later in fiscal year 1999, when equipment ownership is determined.

  1. Heavy Equipment. Trade and Industrial Education Trade Preparatory Training Guide.

    ERIC Educational Resources Information Center

    Nebraska State Dept. of Education, Lincoln. Div. of Vocational Education.

    One of a series of curriculum guides prepared for the building occupations cluster of the construction/fabrication occupational group, this guide identifies the essentials of the heavy equipment trade as recommended by the successful heavy equipment operator. An instructional program based upon the implementation of the guide is expected to…

  2. Common NICU Equipment

    MedlinePLUS

    ... added to your dashboard . The NICU contains many machines and other types of equipment used to care for sick babies with many different problems. These machines seem less intimidating when you understand how they ...

  3. Magnetotelluric Equipment Installation

    USGS Multimedia Gallery

    USGS scientist, Jared Peacock making sure the equipment is set up properly with good data coming in, and programming the data logger to collect magnetotelluric data for 24 hours as NAGT intern, Monica Mustain looks on....

  4. Selecting Library Furniture & Equipment.

    ERIC Educational Resources Information Center

    Media & Methods, 1997

    1997-01-01

    Offers suggestions for selecting school library furniture and equipment. Describes various models of computer workstations; reading tables and chairs; and shelving. Sidebar lists names and addresses of library furniture manufactures and distributors. (AEF)

  5. Equipment & New Products.

    ERIC Educational Resources Information Center

    Poitras, Adrian W., Ed.

    1979-01-01

    Reviews new science equipment and products for the laboratory. Includes hand-held calculators, fiberglass fume hoods, motorized microtomy, disposable mouse cages, and electric timers. Describes 11 products total. Provides manufacturer name, address, and price. (MA)

  6. Cleaning supplies and equipment

    MedlinePLUS

    ... something means to clean it to destroy germs. Disinfectants are the cleaning solutions that are used to ... each solution. You may need to allow the disinfectant to dry on the equipment for a set ...

  7. 14 CFR 25.1353 - Electrical equipment and installations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... adjacent essential equipment. (5) Each nickel cadmium battery installation must have provisions to prevent any hazardous effect on structure or essential systems that may be caused by the maximum amount of... cadmium battery installations must have (i) A system to control the charging rate of the...

  8. Listing of Food Service Equipment.

    ERIC Educational Resources Information Center

    National Sanitation Foundation, Ann Arbor, MI. Testing Lab.

    A comprehensive listing of food service equipment including--(1) companies authorized to use the National Sanitation Foundation seal of approval, and (2) equipment listed as meeting NSF standards including soda fountains, spray-type dishwashers, dishwashing equipment, cooking equipment, commerical cooking and warming equipment, freezers,…

  9. Development of medical equipment alarm monitoring system.

    PubMed

    Yamashita, Yoshinori; Ogaito, Tatoku; Kasamatsu, Shingo

    2013-01-01

    In a hospital, we use a large number of medical equipment. In these use, I support the safe use by the alarm such as errors from medical equipment. There is the instrument notifying of alarm in communication, but there is the instrument by a sound and the light. For the medical safety management, confirmation of the alarm is important. We thought that stability was improved by integrating alarm from the instrument of the different type. Therefore, we thought that we integrated alarm from medical equipment. We decided to transmit an alarm signal from medical equipment by adding radio module program unit. The type of the radio used IEEE 802.15.4 (ZigBee) at a point of view of low power, International Standard, simple radio equipment. This system deals with only alarm information from medical equipment and does not handle the data. However, we understood that we were helpful very much even if it was only alarm information. We were able to in this way reduce the number of incidents. PMID:23920969

  10. Chromium and Genomic Stability

    PubMed Central

    Wise, Sandra S.; Wise, John Pierce

    2014-01-01

    Many metals serve as micronutrients which protect against genomic instability. Chromium is most abundant in its trivalent and hexavalent forms. Trivalent chromium has historically been considered an essential element, though recent data indicate that while it can have pharmacological effects and value, it is not essential. There are no data indicating that trivalent chromium promotes genomic stability and, instead may promote genomic instability. Hexavalent chromium is widely accepted as highly toxic and carcinogenic with no nutritional value. Recent data indicate that it causes genomic instability and also has no role in promoting genomic stability. PMID:22192535

  11. Wellhead equipment support

    SciTech Connect

    Nichols, R.P.

    1987-03-24

    A wellhead assembly is described for supporting equipment in a well, comprising: a suspension nut having a threaded outer surface; a wellhead member having an inner threaded surface adapted to mesh with the threaded outer surface of the suspension nut; the suspension nut having a projection extending axially from its threaded outer surface and having an inner surface adapted to support equipment in the well; at least a portion of the inner surface for supporting the equipment facing both inwardly and upwardly such that force exerted by the weight of the equipment against the inner surface is transformed at least in part to a radially outwardly directed force; the projecting having an outer surface sized such that the outer surface is spaced from an inner surface of the wellhead member in the absence of force exerted against the inner surface of the projection such that the projection is deflected outwardly by the force exerted by the weight of the equipment against the inner surface.

  12. German mining equipment

    SciTech Connect

    Not Available

    1993-10-01

    The German mining equipment industry developed to supply machines and services to the local mining industry, i.e., coal, lignite, salt, potash, ore mining, industrial minerals, and quarrying. The sophistication and reliability of its technology also won it worldwide export markets -- which is just as well since former major domestic mining sectors such as coal and potash have declined precipitously, and others such as ore mining have all but disappeared. Today, German mining equipment suppliers focus strongly on export sales, and formerly unique German mining technologies such as continuous mining with bucket wheel excavators and conveyors for open pits, or plowing of underground coal longwalls are widely used abroad. The status of the German mining equipment industry is reviewed.

  13. [Medical Equipment Maintenance Methods].

    PubMed

    Liu, Hongbin

    2015-09-01

    Due to the high technology and the complexity of medical equipment, as well as to the safety and effectiveness, it determines the high requirements of the medical equipment maintenance work. This paper introduces some basic methods of medical instrument maintenance, including fault tree analysis, node method and exclusive method which are the three important methods in the medical equipment maintenance, through using these three methods for the instruments that have circuit drawings, hardware breakdown maintenance can be done easily. And this paper introduces the processing methods of some special fault conditions, in order to reduce little detours in meeting the same problems. Learning is very important for stuff just engaged in this area. PMID:26904890

  14. Artifacts and essentialism

    PubMed Central

    Gelman, Susan A.

    2013-01-01

    Psychological essentialism is an intuitive folk belief positing that certain categories have a non-obvious inner “essence” that gives rise to observable features. Although this belief most commonly characterizes natural kind categories, I argue that psychological essentialism can also be extended in important ways to artifact concepts. Specifically, concepts of individual artifacts include the non-obvious feature of object history, which is evident when making judgments regarding authenticity and ownership. Classic examples include famous works of art (e.g., the Mona Lisa is authentic because of its provenance), but ordinary artifacts likewise receive value from their history (e.g., a worn and tattered blanket may have special value if it was one's childhood possession). Moreover, in some cases, object history may be thought to have causal effects on individual artifacts, much as an animal essence has causal effects. I review empirical support for these claims and consider the implications for both artifact concepts and essentialism. This perspective suggests that artifact concepts cannot be contained in a theoretical framework that focuses exclusively on similarity or even function. Furthermore, although there are significant differences between essentialism of natural kinds and essentialism of artifact individuals, the commonalities suggest that psychological essentialism may not derive from folk biology but instead may reflect more domain-general perspectives on the world. PMID:23976903

  15. Equipment Operational Requirements

    SciTech Connect

    Greenwalt, B; Henderer, B; Hibbard, W; Mercer, M

    2009-06-11

    The Iraq Department of Border Enforcement is rich in personnel, but poor in equipment. An effective border control system must include detection, discrimination, decision, tracking and interdiction, capture, identification, and disposition. An equipment solution that addresses only a part of this will not succeed, likewise equipment by itself is not the answer without considering the personnel and how they would employ the equipment. The solution should take advantage of the existing in-place system and address all of the critical functions. The solutions are envisioned as being implemented in a phased manner, where Solution 1 is followed by Solution 2 and eventually by Solution 3. This allows adequate time for training and gaining operational experience for successively more complex equipment. Detailed descriptions of the components follow the solution descriptions. Solution 1 - This solution is based on changes to CONOPs, and does not have a technology component. It consists of observers at the forts and annexes, forward patrols along the swamp edge, in depth patrols approximately 10 kilometers inland from the swamp, and checkpoints on major roads. Solution 2 - This solution adds a ground sensor array to the Solution 1 system. Solution 3 - This solution is based around installing a radar/video camera system on each fort. It employs the CONOPS from Solution 1, but uses minimal ground sensors deployed only in areas with poor radar/video camera coverage (such as canals and streams shielded by vegetation), or by roads covered by radar but outside the range of the radar associated cameras. This document provides broad operational requirements for major equipment components along with sufficient operational details to allow the technical community to identify potential hardware candidates. Continuing analysis will develop quantities required and more detailed tactics, techniques, and procedures.

  16. Equipment Management Manual

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The NASA Equipment Management Manual (NHB 4200.1) is issued pursuant to Section 203(c)(1) of the National Aeronautics and Space Act of 1958, as amended (42 USC 2473), and sets forth policy, uniform performance standards, and procedural guidance to NASA personnel for the acquisition, management, and use of NASA-owned equipment. This revision is effective upon receipt. This is a controlled manual, issued in loose-leaf form, and revised through page changes. Additional copies for internal use may be obtained through normal distribution.

  17. Lennox - Student Training Equipment.

    ERIC Educational Resources Information Center

    Lennox Industries, Inc., Marshalltown, IA.

    Presents a series of demonstration units designed by Lennox Industries for the purpose of training students to become familiar with Lennox mechanical equipment. Demonstrators are designed to present technical information in a clear simplified manner thus reducing frustration for the beginning trainee. The following demonstrators are available--(1)

  18. STDN ranging equipment

    NASA Technical Reports Server (NTRS)

    Jones, C. E.

    1975-01-01

    Final results of the Spaceflight Tracking and Data Network (STDN) Ranging Equipment program are summarized. Basic design concepts and final design approaches are described. Theoretical analyses which define requirements and support the design approaches are presented. Design verification criteria are delineated and verification test results are specified.

  19. Lennox - Student Training Equipment.

    ERIC Educational Resources Information Center

    Lennox Industries, Inc., Marshalltown, IA.

    Presents a series of demonstration units designed by Lennox Industries for the purpose of training students to become familiar with Lennox mechanical equipment. Demonstrators are designed to present technical information in a clear simplified manner thus reducing frustration for the beginning trainee. The following demonstrators are available--(1)…

  20. Equipment & New Products.

    ERIC Educational Resources Information Center

    Poitras, Adrian W., Ed.

    1977-01-01

    Identifies several pieces of equipment and new products for use in college science teaching such as: (1)rotary retracting microtome; (2)airflow bench; and (3)digital stop clock. A description of each one, the price, and the address of the seller are also presented. (HM)

  1. Engineer Equipment Operator.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the skills needed by engineer equipment operators. Addressed in the seven individual units of the course are the following topics: introduction to Military Occupation Specialty (MOS) 1345…

  2. Engineer Equipment Chief.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the skills needed by engineer equipment chiefs. Addressed in the five individual units of the course are the following topics: construction management (planning, scheduling, and supervision);…

  3. Equipment & New Products.

    ERIC Educational Resources Information Center

    Poitras, Adrian W., Ed.

    1977-01-01

    Presents information about equipment and new products such as the melting point instrument and TV-microscope coupler which are helpful in college science teaching. Descriptions of each product, how it operates, its prices, and address for ordering are presented. (HM)

  4. Dairy Equipment Lubrication

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Lake To Lake Dairy Cooperative, Manitowoc, Wisconsin, operates four plants in Wisconsin for processing milk, butter and cheese products from its 1,300 member farms. The large co-op was able to realize substantial savings by using NASA information for improved efficiency in plant maintenance. Under contract to Marshall Space Flight Center, Midwest Research Institute compiled a handbook consolidating information about commercially available lubricants. The handbook details chemical and physical properties, applications, specifications, test procedures and test data for liquid and solid lubricants. Lake To Lake's plant engineer used the handbook to effect savings in maintenance labor and materials costs by reducing the number of lubricants used on certain equipment. Strict U.S. Department of Agriculture and Food and Drug Administration regulations preclude lubrication changes n production equipment, but the co-op's maintenance chief was able to eliminate seven types of lubricants for ancillary equipment, such as compressors and high pressure pumps. Handbook data enabled him to select comparable but les expensive lubricants in the materials consolidation process, and simplified lubrication schedules and procedures. The handbook is in continuing use as a reference source when a new item of equipment is purchased.

  5. The EQUIP Program

    ERIC Educational Resources Information Center

    Gibbs, John C.; Potter, Granville Bud; DiBiase, Ann-Marie; Devlin, Renee

    2008-01-01

    Youth who present anti-social behavior need powerful interventions that strengthen empathy, counter negative peer influence, and challenge thinking errors. This article recaps some key points about EQUIP, a Positive Peer Culture (PPC)-based cognitive behavioral intervention program for behaviorally at-risk youth, and notes how the program has

  6. Basic Engineer Equipment Mechanic.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the skills needed by basic engineer equipment mechanics. Addressed in the four individual units of the course are the following topics: mechanics and their tools (mechanics, hand tools, and power…

  7. The EQUIP Program

    ERIC Educational Resources Information Center

    Gibbs, John C.; Potter, Granville Bud; DiBiase, Ann-Marie; Devlin, Renee

    2008-01-01

    Youth who present anti-social behavior need powerful interventions that strengthen empathy, counter negative peer influence, and challenge thinking errors. This article recaps some key points about EQUIP, a Positive Peer Culture (PPC)-based cognitive behavioral intervention program for behaviorally at-risk youth, and notes how the program has…

  8. Modern methods for estimating the strength and lifetime of power equipment subjected to thermal pulsations and vibration

    NASA Astrophysics Data System (ADS)

    Sudakov, A. V.; Slovtsov, S. V.

    2013-01-01

    Modern methods used to estimate the loading of power equipment elements and their lifetime, which may decrease to an essential extent due to temperature pulsations and vibration loads that are sometimes inherent in the working process in power equipment, and which may lead to equipment failures. Procedures for calculating the longevity of power equipment elements experiencing temperature pulsations during their operation are proposed.

  9. 47 CFR 22.863 - Frequency stability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Frequency stability. 22.863 Section 22.863...-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems 22.863 Frequency stability. The frequency stability of equipment used under this subpart shall be sufficient to ensure that,...

  10. 47 CFR 22.863 - Frequency stability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Frequency stability. 22.863 Section 22.863...-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems 22.863 Frequency stability. The frequency stability of equipment used under this subpart shall be sufficient to ensure that,...

  11. 47 CFR 22.863 - Frequency stability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Frequency stability. 22.863 Section 22.863...-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems 22.863 Frequency stability. The frequency stability of equipment used under this subpart shall be sufficient to ensure that,...

  12. The Essential Leadership Model

    ERIC Educational Resources Information Center

    Knuth, Richard K.; Banks, Patricia Anne

    2006-01-01

    This article introduces the reader to the Essential Leadership Model (ELM). The ELM provides a vocabulary and framework for clarifying and prioritizing the many complex and competing demands of the principalship. The ELM supports principals in identifying the critical needs of a school and the leadership knowledge, skills, and dispositions to meet

  13. Physical Education: Essential Issues

    ERIC Educational Resources Information Center

    Green, Ken, Ed.; Hardman, Ken, Ed.

    2005-01-01

    This book is aimed primarily at under and postgraduate students pursuing entire programmes or discrete courses and modules in the broad area of physical education and sport in schools. It consists of a collection of what is considered to be essential readings in the sense that they are contributions from eminent authors on a breadth of salient

  14. Physical Education: Essential Issues

    ERIC Educational Resources Information Center

    Green, Ken, Ed.; Hardman, Ken, Ed.

    2005-01-01

    This book is aimed primarily at under and postgraduate students pursuing entire programmes or discrete courses and modules in the broad area of physical education and sport in schools. It consists of a collection of what is considered to be essential readings in the sense that they are contributions from eminent authors on a breadth of salient…

  15. Treatment of Essential Tremor

    MedlinePLUS

    ... be helpful in treating essential tremor. Evidence shows gabapentin and topiramate can help. There also is evidence ... tremor: • Amantadine • L-tryptophan/ • Olanzapine • Clonidine pyridoxine • Phenobarbital • Gabapentin • Metoprolol • Quetiapine • Glutethimide • Nicardipine • Theophylline Some research suggests ...

  16. Equipment Failure Analysis

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Tennessee Eastman uses NASTRAN to minimize lost production by pinpointing the causes of equipment failures and preventing recurrences. An example of the program's utility involves a large centrifugal fan which developed cracks during start-ups and shutdowns. This information prompted redesign of the fan. Tennessee Eastman has made extensive use of NASTRAN, both as failure analysis tool and as an aid in redesigning production hardware.

  17. Secure authenticated video equipment

    SciTech Connect

    Doren, N.E.

    1993-07-01

    In the verification technology arena, there is a pressing need for surveillance and monitoring equipment that produces authentic, verifiable records of observed activities. Such a record provides the inspecting party with confidence that observed activities occurred as recorded, without undetected tampering or spoofing having taken place. The secure authenticated video equipment (SAVE) system provides an authenticated series of video images of an observed activity. Being self-contained and portable, it can be installed as a stand-alone surveillance system or used in conjunction with existing monitoring equipment in a non-invasive manner. Security is provided by a tamper-proof camera enclosure containing a private, electronic authentication key. Video data is transferred communication link consisting of a coaxial cable, fiber-optic link or other similar media. A video review station, located remotely from the camera, receives, validates, displays and stores the incoming data. Video data is validated within the review station using a public key, a copy of which is held by authorized panics. This scheme allows the holder of the public key to verify the authenticity of the recorded video data but precludes undetectable modification of the data generated by the tamper-protected private authentication key.

  18. Stabilized Zeeman split laser

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The development of a stablized Zeeman split laser for use in a polarization profilometer is discussed. A Hewlett-Packard laser was modified to stabilize the Zeeman split beat frequency thereby increasing the phase measurement accuracy from the Hewlett-Packard 3 degrees to an accuracy of .01 degrees. The addition of a two layered inductive winding converts the laser to a current controlled oscillator whose frequency is linearly related to coil current. This linear relationship between coil current and laser frequency permits phase locking the laser frequency to a stable crystal controlled reference frequency. The stability of the system is examined and the equipment operation procedures are outlined.

  19. Genetics Home Reference: Essential tremor

    MedlinePLUS

    ... essential tremor may be aggravated by emotional stress, anxiety, fatigue, hunger, caffeine, cigarette smoking, or temperature extremes. Essential tremor may appear at any age but is most common in the elderly. Some studies have suggested that people with essential ...

  20. 8. CONTROL AND EQUIPMENT ROOM INTERIOR. MECHANICAL EQUIPMENT ROOM AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. CONTROL AND EQUIPMENT ROOM INTERIOR. MECHANICAL EQUIPMENT ROOM AT RIGHT AND ENTRANCE AT LEFT. Looking east. - Edwards Air Force Base, South Base Sled Track, Firing Control Blockhouse, South of Sled Track at east end, Lancaster, Los Angeles County, CA

  1. 12. VIEW OF REMOTELY OPERATED EQUIPMENT. OPERATORS VIEWED THE EQUIPMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF REMOTELY OPERATED EQUIPMENT. OPERATORS VIEWED THE EQUIPMENT THROUGH A WATER-FILLED WINDOW. (10/8/81) - Rocky Flats Plant, Plutonium Recovery Facility, Northwest portion of Rocky Flats Plant, Golden, Jefferson County, CO

  2. Genetics of essential tremor.

    PubMed

    Tio, Murni; Tan, Eng-King

    2016-01-01

    Essential tremor is one of the most common adult-onset movement disorders. While it is recognized that genes play a major role in ET with ?50% of the affected individuals having a positive family history, identifying underlying genes in both monogenic and complex forms of ET has been a challenging task. Recent discoveries linking LINGO1, FUS and TENM4 to essential tremor have been met with cautious optimism since reproducibility and pathogenicity have been contentious in previously implicated genes. The lack of gold standard diagnostic criteria together with clinical and genetic heterogeneity have presented considerable obstacles. Nevertheless, future genetic studies should adopt a multi-prong genomic approach with adequate sample size, supported by both functional invitro and invivo studies. Elucidation of the pathophysiologic mechanism will lead to better therapeutic strategies and management. PMID:26411503

  3. Pharmacotherapy of Essential Tremor

    PubMed Central

    Hedera, Peter; Cibulčík, František; Davis, Thomas L.

    2013-01-01

    Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly understood. This has limited the development of effective pharmacotherapy. The current therapeutic armamentaria for ET represent the product of careful clinical observation rather than targeted molecular modeling. Here we review their pharmacokinetics, metabolism, dosing, and adverse effect profiles and propose a treatment algorithm. We also discuss the concept of medically refractory tremor, as therapeutic trials should be limited unless invasive therapy is contraindicated or not desired by patients. PMID:24385718

  4. Pharmacotherapy of essential tremor.

    PubMed

    Hedera, Peter; Cibulčík, František; Davis, Thomas L

    2013-01-01

    Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly understood. This has limited the development of effective pharmacotherapy. The current therapeutic armamentaria for ET represent the product of careful clinical observation rather than targeted molecular modeling. Here we review their pharmacokinetics, metabolism, dosing, and adverse effect profiles and propose a treatment algorithm. We also discuss the concept of medically refractory tremor, as therapeutic trials should be limited unless invasive therapy is contraindicated or not desired by patients. PMID:24385718

  5. Overview of essential tremor.

    PubMed

    Zesiewicz, Theresa A; Chari, Abinaya; Jahan, Israt; Miller, Amber M; Sullivan, Kelly L

    2010-01-01

    Essential tremor (ET) is one of the most common movement disorders in the world. Despite this, only one medication (propranolol) is approved by the Food and Drug Administration (FDA) to treat it. Fortunately, recent studies have identified some additional medications as treatment of ET. Surgical procedures, such as deep brain stimulation of the ventral intermediate nucleus of the thalamus, offer treatment for refractory tremor. The epidemiology, pathogenesis, and medical and surgical treatment of ET will be discussed in this paper. PMID:20856604

  6. Overview of essential tremor

    PubMed Central

    Zesiewicz, Theresa A; Chari, Abinaya; Jahan, Israt; Miller, Amber M; Sullivan, Kelly L

    2010-01-01

    Essential tremor (ET) is one of the most common movement disorders in the world. Despite this, only one medication (propranolol) is approved by the Food and Drug Administration (FDA) to treat it. Fortunately, recent studies have identified some additional medications as treatment of ET. Surgical procedures, such as deep brain stimulation of the ventral intermediate nucleus of the thalamus, offer treatment for refractory tremor. The epidemiology, pathogenesis, and medical and surgical treatment of ET will be discussed in this paper. PMID:20856604

  7. Causal Essentialism in Kinds

    PubMed Central

    Ahn, Woo-kyoung; Taylor, Eric G.; Kato, Daniel; Marsh, Jessecae K.; Bloom, Paul

    2014-01-01

    The current study examines Causal Essentialism, derived from Psychological Essentialism of concepts (Medin & Ortony, 1989). We examine whether people believe that members of a category share some underlying essence that is both necessary and sufficient for category membership and that also causes surface features. The main claim is that Causal Essentialism is restricted to categories that correspond to our intuitive notions of existing kinds, and hence is more attenuated for categories that are based on arbitrary criteria. Experiments 1 and 3 found that people overtly endorse causal essences in non-arbitrary kinds but are less likely to do so for arbitrary categories. Experiments 2 and 4 found that people were more willing to generalize a members known causal relations (or lack thereof) when dealing with a kind than when dealing with an arbitrary category. These differences between kinds and arbitrary categories were found across various domainsnot only categories of living things, but also for artifacts. These findings have certain real-world implications, including how people make sense of mental disorders that are treated as real kinds. PMID:23098315

  8. Highway Maintenance Equipment Operator. Specialized Equipment. Training Materials.

    ERIC Educational Resources Information Center

    Perky, Sandra Dutreau; And Others

    This curriculum guide provides instructional materials to assist in training equipment operators in the safe and effective use of highway maintenance equipment. It includes 18 units of instruction covering the large equipment used in maintenance operations. Each unit of instruction consists of eight basic components: performance objectives,

  9. Highway Maintenance Equipment Operator. Miscellaneous Equipment. Training Materials.

    ERIC Educational Resources Information Center

    Perky, Sandra Dutreau; And Others

    This curriculum guide provides instructional materials to assist in training equipment operators in the safe and effective use of highway maintenance equipment. It includes six units of instruction covering the small, specialized equipment used in maintenance operations. Each unit of instruction consists of eight basic components: performance

  10. Getting Equipped and Staying Equipped, Part 2: Finding the Funds.

    ERIC Educational Resources Information Center

    Jordahl, Gregory; Orwig, Ann

    1995-01-01

    Suggests how school libraries can fund computer equipment; gain assistance from high-tech businesses; develop business partnerships and foundations; lease equipment; accept equipment donations; fund raise; build money into the budget; and communicate school needs with budget voters. Sidebars include leasing advice; resources for parent-teacher

  11. Precision Instrument and Equipment Repairers.

    ERIC Educational Resources Information Center

    Wyatt, Ian

    2001-01-01

    Explains the job of precision instrument and equipment repairers, who work on cameras, medical equipment, musical instruments, watches and clocks, and industrial measuring devices. Discusses duties, working conditions, employment and earnings, job outlook, and skills and training. (JOW)

  12. Monitoring equipment for multitasking multimicroprocessors

    SciTech Connect

    Negrini, R.; Pozzi, F.; Scarabottolo, N.

    1983-01-01

    The structure of monitoring equipment capable of evaluating performances of multimicroprocessor systems is described. The goals and field of application of such equipment are discussed, along with characteristics both at the hardware and software levels. 4 references.

  13. Abyssal soil investigation equipment

    SciTech Connect

    Smits, F.P.; Maggioni, W.; Mainardi, U.

    1994-12-31

    The present paper deals with the development of a testing device for quick offshore geotechnical investigations. The equipment, at present, consists of a penetrometer, mounted on a sea bed platform, a handling frame and a control cabin; a further development includes a drill rig and a geotechnical laboratory. All this is designed so as to be an autonomous unit that can be handled by various types of non-specialized ships which have the necessary deck space. The sea bed platform can operate in 2,000 m of waterdepth and is provided with a hydraulic penetrometer, with a thrust capacity of 400 kN, able to carry out cone penetration type testing until a depth of more than 100 m, as well as shallow depth continuous sampling. The penetrometer can be equipped with a series of probes (piezocone, pressiocone, total radial pressure transducer, seismic cone) allowing the execution of the wide range of direct geotechnical measurements normally performed during on-land penetration tests.

  14. Safety Equipment in the Lab.

    ERIC Educational Resources Information Center

    Denham, Willard A.S.

    1964-01-01

    Findings of two recent surveys on safety equipment in laboratory facilities are presented. The first survey was a pilot study of emergency shower and eye wash equipment. This study was followed by a more comprehensive random survey of safety equipment in 2,820 labs. Among other findings, the surveys indicate that many plants are underequipped, or

  15. Scientist Using Terrestrial Lidar Equipment

    USGS Multimedia Gallery

    Chris Soulard using the Terrestrial Lidar to scan study area in the Grand Canyon-Parashant National Monument, AZ.  Note the bag of ice on the equipment.  High temperates can cause equipment to overheat, requiring scientists to be creative in protecting equipment....

  16. The essential moral self.

    PubMed

    Strohminger, Nina; Nichols, Shaun

    2014-04-01

    It has often been suggested that the mind is central to personal identity. But do all parts of the mind contribute equally? Across five experiments, we demonstrate that moral traits-more than any other mental faculty-are considered the most essential part of identity, the self, and the soul. Memory, especially emotional and autobiographical memory, is also fairly important. Lower-level cognition and perception have the most tenuous connection to identity, rivaling that of purely physical traits. These findings suggest that folk notions of personal identity are largely informed by the mental faculties affecting social relationships, with a particularly keen focus on moral traits. PMID:24503450

  17. Gender and Psychological Essentialism

    PubMed Central

    Heyman, Gail D.; Giles, Jessica W.

    2010-01-01

    SUMMARY When individuals reason in an essentialist way about social categories, they assume that group differences reflect inherently different natures (Gelman, 2003; Rothbart & Taylor, 1992). This paper describes the psychological and social implications of essentialist beliefs, and examines the extent to which children exhibit psychological essentialism when reasoning about gender. The authors discuss reasons young children as well as older children show essentialist reasoning in some contexts, but not in others. Finally, the authors suggest directions for future research, and discuss a primary challenge to many working in this field: reduction of rigid gender beliefs. PMID:21528097

  18. Captopril in essential hypertension

    PubMed Central

    Estrada, E. Rabinad; Morin, M. Ingelmo; Amenos, A. Martinez; Alsina, J.; Gorina, A. Balcells

    1982-01-01

    1 Forty-one patients with essential hypertension, stages I, II, and III, were treated with captopril alone or in combination with hydrochlorothiazide. Forty two percent were responsive to captopril alone, while the remaining 58% also required the diuretic. The need for the diuretic was related to the phase of hypertension. 2 There was no significant relation between drug response and plasma renin activity. Serum concentrations of creatinine and potassium remained normal, and there were no pathological changes in serum glucose, cholesterol, uric acid concentrations, erythrocyte count, packed cell volume, haemoglobin, or heart rate. 3 Captopril was well tolerated. One patient developed a rash and another ageusia, which disappeared spontaneously. A third, who was also taking allopurinol, developed leucopenia but it disappeared after treatment was withdrawn. There were no cases of proteinuria attributable to captopril; and proteinuria disappeared in four of five patients who were proteinuric before the start of treatment. 4 These findings suggest that doses of captopril of 150 mg to 300 mg (with or without a diuretic) may be adequate for controlling the blood pressure of most patients with essential hypertension. PMID:6753890

  19. Benefits of Digital Equipment Generic Qualification Activities

    SciTech Connect

    Thomas, James E.; Steiman, Samuel C.

    2002-07-01

    As a result of nuclear power plant instrumentation and control obsolescence issues, there have been numerous activities during recent years relating to the qualification of digital equipment. Some of these activities have been 'generic' in nature in that the qualification was not limited to plant specific applications, but was intended to cover a broad base of potential applications of the digital equipment. These generic qualifications have been funded by equipment manufacturers and by utility groups and organizations. The generic activities sponsored by the Electric Power Research Institute (EPRI) have been pilot projects for an overall generic qualification approach. The primary benefit resulting from the generic qualification work to date is that a number of digital platforms and digital devices are now available for use in various nuclear safety-related applications. Many of the tests and evaluations necessary to support plant specific applications have been completed. The amount of data and documentation that each utility must develop on a case by case basis has been significantly reduced. There are also a number of additional benefits resulting from these industry efforts. The challenges and difficulties in qualifying digital equipment for safety-related applications are now more clearly understood. EPRI has published a lessons learned document (EPRI Report 1001452, Generic Qualification of Commercial Grade Digital Devices: Lessons Learned from Initial Pilots, which covers several different qualification areas, including device selection, project planning, vendor surveys and design reviews, and electromagnetic compatibility (EMC) qualification. Application of the experience and lessons learned from the EPRI pilot activities should help reduce the effort and cost required for future qualification work. Most generic qualification activities for commercial equipment have been conducted using the approach of EPRI TR-106439, Guideline on Evaluation and Acceptance of Commercial Grade Digital Equipment for Nuclear Safety Applications, and the supplemental guidance of EPRI TR-107339, Evaluating Commercial Digital Equipment for High Integrity Applications. The U.S. Nuclear Regulatory Commission (NRC) has reviewed some of the qualification activities and reports and issued a number of Safety Evaluation Reports (SERs). Although some additional work may be required to support specific applications, the generic qualification activities and NRC reviews have provided significant clarification and further stabilized the regulatory environment for use of digital equipment in safety-related applications. (authors)

  20. Orbital construction support equipment

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Approximately 200 separate construction steps were defined for the three solar power satellite (SPS) concepts. Detailed construction scenarios were developed which describe the specific tasks to be accomplished, and identify general equipment requirements. The scenarios were used to perform a functional analysis, which resulted in the definition of 100 distinct SPS elements. These elements are the components, parts, subsystems, or assemblies upon which construction activities take place. The major SPS elements for each configuration are shown. For those elements, 300 functional requirements were identified in seven generic processes. Cumulatively, these processes encompass all functions required during SPS construction/assembly. Individually each process is defined such that it includes a specific type of activity. Each SPS element may involve activities relating to any or all of the generic processes. The processes are listed, and examples of the requirements defined for a typical element are given.

  1. Planning equipment acquisitions.

    PubMed

    Sadock, J M

    1995-08-01

    As the mire of healthcare reform continues to grow, many providers are developing an insatiable appetite for alternatives to the way they currently do business. For some, solutions come in the form of repackaging the same old stuff. Others have jumped recklessly into every managed, capitated, or reformed idea that has come along. Old-school thinkers are still awaiting government direction. Providers of quality healthcare face increasing demands on their shrinking capital funds. An aging population, indigent care, AIDS patients, medical waste disposal, nursing shortages, declining reimbursement, increasing labor costs, and the federal healthcare reform threat have negatively affected cash flow. Though previous cost-plus reimbursement encouraged wasteful spending, the threat of healthcare reform has already caused providers and suppliers alike to work together to cut costs even without government mandates. The impact has been the closure of over 600 facilities nationwide in the past ten years. More than 70,000 acute care hospital beds have been lost from the US healthcare system. Many healthcare facilities have merged into managed care systems, integrated delivery networks, and regional alliances whose costs can be consolidated and controlled. At the same time, new services and profit centers are also being created to increase revenue. A healthcare moves into alternative care environments--home care, ambulatory care, diagnostic testing--these providers need more capital equipment to serve an increased patient load. Coupled with an aging installed base of technology in the acute care environment, healthcare managers face an ever-growing need for capital equipment and creative financing programs to meet longer payment options.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:10144860

  2. Protein stability: a crystallographer's perspective.

    PubMed

    Deller, Marc C; Kong, Leopold; Rupp, Bernhard

    2016-02-01

    Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food industries, in addition to being a daily consideration for academic researchers studying proteins. An understanding of protein stability is essential for optimizing the expression, purification, formulation, storage and structural studies of proteins. In this review, discussion will focus on factors affecting protein stability, on a somewhat practical level, particularly from the view of a protein crystallographer. The differences between protein conformational stability and protein compositional stability will be discussed, along with a brief introduction to key methods useful for analyzing protein stability. Finally, tactics for addressing protein-stability issues during protein expression, purification and crystallization will be discussed. PMID:26841758

  3. Essential biodiversity variables

    USGS Publications Warehouse

    Pereira, H.M.; Ferrier, S.; Walters, M.; Geller, G.N.; Jongman, R.H.G.; Scholes, R.J.; Bruford, M.W.; Brummitt, N.; Butchart, S.H.M.; Cardoso, A.C.; Coops, N.C.; Dulloo, E.; Faith, D.P.; Freyhof, J.; Gregory, R.D.; Heip, C.; Höft, R.; Hurtt, G.; Jetz, W.; Karp, D.S.; McGeoch, M.A.; Obura, D.; Onada, Y.; Pettorelli, N.; Reyers, B.; Sayre, R.; Scharlemann, J.P.W.; Stuart, S.N.; Turak, E.; Walpole, M.; Wegmann, M.

    2013-01-01

    Reducing the rate of biodiversity loss and averting dangerous biodiversity change are international goals, reasserted by the Aichi Targets for 2020 by Parties to the United Nations (UN) Convention on Biological Diversity (CBD) after failure to meet the 2010 target (1, 2). However, there is no global, harmonized observation system for delivering regular, timely data on biodiversity change (3). With the first plenary meeting of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) soon under way, partners from the Group on Earth Observations Biodiversity Observation Network (GEO BON) (4) are developing—and seeking consensus around—Essential Biodiversity Variables (EBVs) that could form the basis of monitoring programs worldwide.

  4. John Adams' essential tremor.

    PubMed

    Louis, Elan D; Kavanagh, Patricia

    2005-12-01

    John Adams (1735-1826), one of the signers of the Declaration of Independence, was the second President of the United States. Adams had tremor for many years, about which little has been written. We examined John Adams' penmanship over a 62-year period and studied his correspondence and diaries. It is not clear when Adams' tremor began, although in a diary entry dated 6 December 1760, when Adams was 25 years old, there is evidence of low-amplitude kinetic tremor. The tremor continued in his written correspondence, becoming more persistent over time. Later in life, the clarity of his written correspondence diminished, with greater decomposition of characters and a reduction in the size of individual characters. This finding raises some speculation as to whether Adams could have been developing some parkinsonism, although the evidence in favor of this is not compelling. The most likely diagnosis was essential tremor. PMID:16078215

  5. Teletherapy equipment and simulators

    SciTech Connect

    de Almeida, C.E.; Cecatti, E.R.

    1984-06-01

    A comprehensive Quality Assurance program in a radiation therapy center is desirable regardless of its size, and should cover among others the following areas: physical parameters of the therapy machines, dosimetric standards, preventive maintenance of radiation emitting sources and measuring instruments. In a radiation therapy center, regardless of its size and patient load, it is advisable to have a quality assurance program covering all the treatment planning steps. The following areas should be taken into consideration: physical parameters of the machines; dosimetric standards; radiation safety procedures and preventive maintenance of irradiators and radiation measuring instruments. The minimum instrumentation required and the critical parameters to be observed to establish a quality assurance program are discussed; the suggestions are applicable to the various sizes of radiation therapy centers. It is essential that all the procedures and results obtained are well documented and a critical evaluation of the program be performed periodically.

  6. Sludge stabilization operability test report

    SciTech Connect

    Lewis, W.S.

    1994-11-08

    Document provides the results of the Operability Test Procedure performed to test the operability of the HC-21C thermal stabilization process for sludge. The OTP assured all equipment functioned properly and established the baseline temperature profile for glovebox HC-21C.

  7. Genetics Home Reference: Essential thrombocythemia

    MedlinePLUS

    ... gov - Linking patients to medical research PubMed - Recent literature OMIM - Genetic disorder catalog What other names do people use for essential thrombocythemia? essential thrombocytosis primary thrombocythemia primary thrombocytosis For more information about naming ...

  8. Equipment for drilling miniature holes

    SciTech Connect

    Gillespie, L K

    1981-04-01

    Miniature holes are produced on 16 different types of mechanical drilling equipment. Each equipment type has significant advantages for a specific type of part. The basic capabilities vary greatly between equipment types. Some produce very precise holes and others produce very high volumes of commercial tolerance holes. At the present time machines are available for mechanicaly drilling up to 100,000 miniature holes per hour. Lasers currently are drilling as many as 15,000,000 ultra-miniature holes per hour.

  9. VIEW OF MICROMACHINING, HIGH PRECISION EQUIPMENT USED TO CUSTOM MAKE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF MICRO-MACHINING, HIGH PRECISION EQUIPMENT USED TO CUSTOM MAKE SMALL PARTS. LUMPS OF CLAY; SHOWN IN THE PHOTOGRAPH, WERE USED TO STABILIZE PARTS BEING MACHINED. (11/1/87) - Rocky Flats Plant, Stainless Steel & Non-Nuclear Components Manufacturing, Southeast corner of intersection of Cottonwood & Third Avenues, Golden, Jefferson County, CO

  10. Orbiter electrical equipment utilization baseline

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The baseline for utilization of Orbiter electrical equipment in both electrical and Environmental Control and Life Support System (ECLSS) thermal analyses is established. It is a composite catalog of Space Shuttle equipment, as defined in the Shuttle Operational Data Book. The major functions and expected usage of each component type are described. Functional descriptions are designed to provide a fundamental understanding of the Orbiter electrical equipment, to insure correlation of equipment usage within nominal analyses, and to aid analysts in the formulation of off-nominal, contingency analyses.

  11. Information technology equipment cooling system

    SciTech Connect

    Schultz, Mark D.

    2014-06-10

    According to one embodiment, a system for removing heat from a rack of information technology equipment may include a sidecar indoor air to liquid heat exchanger that cools warm air generated by the rack of information technology equipment. The system may also include a liquid to liquid heat exchanger and an outdoor heat exchanger. The system may further include configurable pathways to connect and control fluid flow through the sidecar heat exchanger, the liquid to liquid heat exchanger, the rack of information technology equipment, and the outdoor heat exchanger based upon ambient temperature and/or ambient humidity to remove heat from the rack of information technology equipment.

  12. Laser Frequency Stabilization

    NASA Technical Reports Server (NTRS)

    Donelan, Darsa; Mueller, Guido; Thorpe, James; Livas, Jeffrey

    2011-01-01

    Laser ranging and interferometry are essential technologies allowing for many astounding new spacebased missions such as the Laser Interferometer Space Antenna (LISA) to measure gravitational radiation emitted from distant super massive black hole mergers or distributed aperture telescopes with unprecedented angular resolution in the NIR or visible regime. The requirements on laser frequency noise depend on the residual motion and the distances between the spacecraft forming the interferometer. The intrinsic frequency stability of commercial lasers is several orders of magnitude above these requirements. Therefore, it is necessary for lasers to be stabilized to an ultrastable frequency reference so that they can be used to sense and control distances between spacecraft. Various optical frequency references and frequency stabilization schemes are considered and investigated for the applicability and usefulness for space-based interferometry missions.

  13. VIEW OF ULTRASONIC TESTING EQUIPMENT IN BUILDING 991. THIS EQUIPMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF ULTRA-SONIC TESTING EQUIPMENT IN BUILDING 991. THIS EQUIPMENT NON-DESTRUCTIVELY TESTS WEAPONS COMPONENTS FOR FLAWS AND CRACKS. (9/11/85) - Rocky Flats Plant, Final Assembly & Shipping, Eastern portion of plant site, south of Spruce Avenue, east of Tenth Street & north of Central Avenue, Golden, Jefferson County, CO

  14. 141. ARAIII Equipment location plan. Includes list of equipment and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    141. ARA-III Equipment location plan. Includes list of equipment and location in reactor, control, and other buildings. Aerojet-general 880-area/GCRE-101-U-1. Date: February 1958. Ineel index code no. 063-0101-65-013-192508. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

  15. Power Product Equipment Technician: Equipment Systems. Teacher Edition. Student Edition.

    ERIC Educational Resources Information Center

    Hilley, Robert

    This packet contains teacher and student editions on the topic of equipment systems, intended for the preparation of power product equipment technicians. This publication contains seven units: (1) principles of power transmission; (2) mechanical drive systems; (3) principles of fluid power; (4) hydraulic and pneumatic drive systems; (5) wheel and

  16. Laptop image transmission equipment

    NASA Astrophysics Data System (ADS)

    Mocenter, Michael M.

    1991-12-01

    Imagery and other visual information have become a critical element in planning and performing modern military operations. The effectiveness of this imagery information is often directly tied to the time it takes to get from the collector of this imagery to the user of the imagery. Hard copy distribution of annotated imagery to the tactical commander is hampered by the lack of effective communications paths, and the tactical use of hand held imagery is restricted by the lack of film processing facilities. The military has begun to rely on electronic imagery and digital communications technology for answers, with some success. The new obstacles created by applied electronic imagery are interoperability standards and effective use of communications bandwidth in a tactical environment. New technological developments in computer hardware/software have changed this situation by allowing for the gathering, dissemination, and transfer of near-real-time information to various intelligence audiences at any location. The Naval Air Development Center (NAVAIRDEVCEN) has coupled commercial-off-the-shelf (COTS) technology with National Image Transmission Formats (NITF) Standards to develop a Secondary Imagery Dissemination System (SIDS) package that is designed to meet the flexibility challenge of the tactical military environment. This tailorable SIDS package is called Laptop Image Transmission Equipment (LITE). The LITE system is an extension of the Navy's existing Fleet Imagery Support Terminal (FIST) into the man-portable tactical environment. As such, LITE development is focused on developing flexible imagery input (from sources such as filmless cameras) and connectivity to tactical communications paths and ruggedization/miniaturization issues. The LITE system, in prototype form, has already found application through operational use in special operations, counter narcotics operations, and classic air/ground/sea military operations. This paper provides an overview of the LITE components, specifications, operations, and future developments for the system.

  17. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  18. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  19. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  20. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  1. 46 CFR 108.301 - Stability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Stability. 108.301 Section 108.301 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Stability... Mobile Offshore Drilling Units....

  2. Local anaesthetics: 10 essentials.

    PubMed

    Lirk, Philipp; Picardi, Susanne; Hollmann, Markus W

    2014-11-01

    This review seeks to address 10 essential questions regarding the clinical use of local anaesthetics. Each local anaesthetic has distinctive physicochemical properties but with the same mode of action; they block voltage-gated sodium channels in the axon. Sodium channel block is brought about by a conformational change and the creation of a positive charge in the channel pore. Different local anaesthetics can reach the local anaesthetic binding site in the axon from the cytoplasmic compartment (classic hydrophilic pathway), or directly via its lipid membrane (hydrophobic pathway), or can enter via large-pore channels (alternative hydrophilic pathway). Beyond the nervous system, local anaesthetics exert beneficial effects on pain and can affect the inflammatory response and the haemostatic system. There are problems with the efficacy of local anaesthetics in the presence of local inflammation, and with significant intravascular toxicity, which can be fatal. But when preventive measures are taken, the incidence of cardiac arrest is low. Intralipid has been proposed to treat systemic local anaesthetic overdose and has been enthusiastically adopted worldwide, even though the mechanism of action is incompletely understood. Intralipid is an aid to the management of local anaesthetic toxicity rather than an antidote and meticulous conduct of regional anaesthesia remains paramount. All local anaesthetics are toxic, in a dose- and time-dependent manner, on virtually all tissues, including nerves and muscles. The question of whether local anaesthetics protect against perioperative tumour progression cannot be answered at this moment, and results from clinical (retrospective) studies are equivocal. Future areas of interest will be the design of new subtype-specific sodium channel blockers, but as we look forward, older local anaesthetics such as 2-chloroprocaine are being reintroduced into the clinical setting. Multimodal perineural analgesia and liposomal bupivacaine may replace catheter techniques for some indications. PMID:25192265

  3. Waterflood equipment requirements for enhanced oil recovery projects

    SciTech Connect

    Hankins, H.

    1983-09-01

    All enhanced oil recovery (EOR) project waterfloods are essentially the same. However, EOR waterflood surface equipment can run the scale from simple to very sophisticated. In a waterflood, a prime objective must be kept in mind: match the best equipment for the job as dictated by reservoir studies pointing to injection of a certain volume of fluid at a certain pressure. Basically, all floods have suction system, with tanks for water storage; pump or pumps, to inject water at required pressure and volume; discharge system to carry injection water to a central distribution manifold; distribution system to carry fluid to injection wells; as well as controls and flow-measuring devices that allow an operator to monitor and regulate equipment performance--which must be tailored to suit operator requirements and preferences. An oil field supply company evaluates waterflood equipment requirements for EOR projects.

  4. Comprehensive framework for preventive maintenance priority of medical equipment.

    PubMed

    Saleh, Neven; Balestra, Gabriella

    2015-08-01

    Throughout the medical equipment life cycle, preventive maintenance is considered one of the most important stages that should be managed properly. However, the need for better management and control by giving a reasonable prioritization for preventive maintenance becomes essential. The purpose of this study is to develop a comprehensive framework for preventive maintenance priority of medical equipment using Quality Function Deployment (QFD) and Fuzzy Logic (FL). The quality function deployment is proposed in order to identify the most important criteria that could impact preventive maintenance priority decision; meanwhile the role of the fuzzy logic is to generate a priority index of the list of equipment considering those criteria. The model validation was carried out on 140 pieces of medical equipment belonging to two hospitals. In application, we propose to classify the priority index into five classes. The results indicate that the strong correlation existence between risk-based criteria and preventive maintenance priority decision. PMID:26736488

  5. [State of the art and outlook for promoting Russian-made hemodialysis equipment with regeneration of dialyzing solution].

    PubMed

    Viktorov, V A; Varin, A N; Grinval'd, V M; Maksimov, E P; Fomicheva, N N; Zavalishin, Iu K; Leshchinski?, G M; Razhev, I I; Noskov, S G; Shadiev, B Sh; Rodin, V V; Strelkov, S I; Shukov, O V; Turiaev, A D; Shishkin, S V

    2003-01-01

    Radical improvements in the physiological features and self-sufficiency of hemodialysis equipment, an essential reduction of the volume of dialyzate contacting with patient's body and elimination of dependence of the equipment operation on the availability of a water-supply network can be ensured by applying a regime of circulation of a relatively small volume (3-5 l) of dialyzate through the regenerating device. The regeneration unit must eliminate the organic products of dialysis from the dialyzate and stabilize the ionic composition of the purified dialyzate according to the preset parameters. Modern methods and technical means for regenerating the used dialyzate are discussed; a regeneration unit, which ensures an electrochemical oxidation (in the used dialyzate) of nitrogen-containing organic metabolites with a subsequent sorption-type additional purification of electrochemically-processed dialyzate, is offered. The regeneration unit is made up of an electrolyser, a sorption-type additional-purification device and a gas utilizer; it eliminates organic metabolites, phosphorus, calcium and potassium from the used dialyzate and stabilizes the pH solution. PMID:12608066

  6. Available Equipment in School Foodservice.

    ERIC Educational Resources Information Center

    Meyer, Mary Kay

    This report provides data on the National Food Service Management Institute's multi-year research project that identified type, style, age, and condition of available food service equipment in K-12 schools nationwide. The study found that smaller schools, serving less than 400 lunches per day, had kitchens equipped with ranges, small

  7. Food Service Equipment and Appurtenances.

    ERIC Educational Resources Information Center

    National Sanitation Foundation, Ann Arbor, MI.

    Equipment design specifications are presented relating to tables of all kinds, counters, sinks and drainboards, bins, shelves, drawers, hoods and similar kitchen appurtenances, not including baking, roasting, toasting, broiling or frying equipment, food preparation machinery such as slicers, choppers, and cutters, mixers and grinders, steam…

  8. Heavy Equipment Mechanic. Instructor Edition.

    ERIC Educational Resources Information Center

    Hendrix, Laborn J.; And Others

    This manual is intended to assist heavy equipment instructors in teaching the latest concepts and functions of heavy equipment. It includes 7 sections and 27 instructional units. Sections (and units) are: orientation (shop safety and first aid, hand tools and miscellaneous tools, measuring, basic rigging and hoisting), engines (basic engine

  9. Food Service Equipment. Third Edition.

    ERIC Educational Resources Information Center

    Jernigan, Anna Katherine; Ross, Lynne Nannen

    This book provides information that will help in purchasing the kind of food service equipment most useful in any given facility. Hence, it should be of value to architects, contractors, administrators, dietitians, managers, and others involved in remodeling a facility, replacing equipment, and/or improving the efficiency of food service…

  10. Heavy Equipment Mechanic. Instructor Edition.

    ERIC Educational Resources Information Center

    Hendrix, Laborn J.; And Others

    This manual is intended to assist heavy equipment instructors in teaching the latest concepts and functions of heavy equipment. It includes 7 sections and 27 instructional units. Sections (and units) are: orientation (shop safety and first aid, hand tools and miscellaneous tools, measuring, basic rigging and hoisting), engines (basic engine…

  11. Heavy Equipment Mechanic Program Guide.

    ERIC Educational Resources Information Center

    Georgia Univ., Athens. Dept. of Vocational Education.

    Designed to train an entry-level mechanic, this heavy equipment mechanic program guide presents the standard curriculum for technical institutes in Georgia. The curriculum addresses the minimum competencies for a heavy equipment mechanic program. The general information section contains the following: purpose and objectives; program description,

  12. ISAARE: Information System for Adaptive, Assistive, and Recreational Equipment: Volume I: Existence; Volume II, Communication; Volume V, Adaptation.

    ERIC Educational Resources Information Center

    Melichar, Joseph F.

    Described as part of the Information System for Adaptive, Assistive and Recreational Equipment are equipment items for physically handicapped pupils in the functional areas of existence, equipment and adaptation. Reviewed in the existence section are such items as assistive food containers and container stabilizers, feeder accessories, bowel and

  13. Aeration equipment for small depths

    NASA Astrophysics Data System (ADS)

    Slue, Jan; Pochyl, Frantiek

    2015-05-01

    Deficit of air in water causes complications with cyanobacteria mainly in the summer months. Cyanobacteria is a bacteria that produces poison called cyanotoxin. When the concentration of cyanobacteria increases, the phenomena "algal bloom" appears, which is very toxic and may kill all the organisms. This article describes new equipment for aeration of water in dams, ponds and reservoirs with small depth. This equipment is mobile and it is able to work without any human factor because its control is provided by a GPS module. The main part of this equipment consists of a floating pump which pumps water from the surface. Another important part of this equipment is an aerator where water and air are blended. Final aeration process runs in the nozzles which provide movement of all this equipment and aeration of the water. Simulations of the flow are solved by multiphase flow with diffusion in open source program called OpenFOAM. Results will be verified by an experiment.

  14. Information technology equipment cooling method

    DOEpatents

    Schultz, Mark D.

    2015-10-20

    According to one embodiment, a system for removing heat from a rack of information technology equipment may include a sidecar indoor air to liquid heat exchanger that cools air utilized by the rack of information technology equipment to cool the rack of information technology equipment. The system may also include a liquid to liquid heat exchanger and an outdoor heat exchanger. The system may further include configurable pathways to connect and control fluid flow through the sidecar heat exchanger, the liquid to liquid heat exchanger, the rack of information technology equipment, and the outdoor heat exchanger based upon ambient temperature and/or ambient humidity to remove heat generated by the rack of information technology equipment.

  15. 14 CFR 121.341 - Equipment for operations in icing conditions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... functioning deicing anti-icing equipment protecting each propeller, windshield, wing, stabilizing or control surface, and each airspeed, altimeter, rate of climb, or flight attitude instrument system; or (3)...

  16. Membrane stabilizer

    DOEpatents

    Mingenbach, William A. (P.O. Box 49, Taos, NM 87571)

    1988-01-01

    A device is provided for stabilizing a flexible membrane secured within a frame, wherein a plurality of elongated arms are disposed radially from a central hub which penetrates the membrane, said arms imposing alternately against opposite sides of the membrane, thus warping and tensioning the membrane into a condition of improved stability. The membrane may be an opaque or translucent sheet or other material.

  17. Does Shoulder Stabilizations Stabilize Shoulders?

    ClinicalTrials.gov

    2016-03-26

    Glenohumeral Stabilization; Computer Tomography; Subtle or Minor Instability; Unstable Painful Shoulder; Apprehension; Dislocation; Subluxation; Kinematics Modeling; Biomechanics; Motion Capture; 3D Simulation

  18. Discovery of essential fatty acids

    PubMed Central

    Spector, Arthur A.; Kim, Hee-Yong

    2015-01-01

    Dietary fat was recognized as a good source of energy and fat-soluble vitamins by the first part of the 20th century, but fatty acids were not considered to be essential nutrients because they could be synthesized from dietary carbohydrate. This well-established view was challenged in 1929 by George and Mildred Burr who reported that dietary fatty acid was required to prevent a deficiency disease that occurred in rats fed a fat-free diet. They concluded that fatty acids were essential nutrients and showed that linoleic acid prevented the disease and is an essential fatty acid. The Burrs surmised that other unsaturated fatty acids were essential and subsequently demonstrated that linolenic acid, the omega-3 fatty acid analog of linoleic acid, is also an essential fatty acid. The discovery of essential fatty acids was a paradigm-changing finding, and it is now considered to be one of the landmark discoveries in lipid research. PMID:25339684

  19. Essential Medicines: An Indian Perspective.

    PubMed

    Maiti, Rituparna; Bhatia, Vikas; Padhy, Biswa Mohan; Hota, Debasish

    2015-01-01

    The concept of defining essential medicines and establishing a list of them was aimed to improve the availability of affordable medicines for the world's poor. Access to essential medicines is a major determinant of health outcomes. Several countries have made substantial progress towards increasing access to essential medicines, but access to essential medicines in developing countries like India is not adequate. In this review we have tried to present the Indian scenario in respect to availability and accessibility of essential medicines over last one decade. To enhance the credibility of Indian healthcare system, procurement and delivery systems of essential medicines have to be strengthened through government commitment, careful selection, adequate public sector financing, efficient distribution systems, control on taxes and duties, and inculcating a culture of rational use of medicines in current and future prescribers. PMID:26435594

  20. Essential Medicines: An Indian Perspective

    PubMed Central

    Maiti, Rituparna; Bhatia, Vikas; Padhy, Biswa Mohan; Hota, Debasish

    2015-01-01

    The concept of defining essential medicines and establishing a list of them was aimed to improve the availability of affordable medicines for the world's poor. Access to essential medicines is a major determinant of health outcomes. Several countries have made substantial progress towards increasing access to essential medicines, but access to essential medicines in developing countries like India is not adequate. In this review we have tried to present the Indian scenario in respect to availability and accessibility of essential medicines over last one decade. To enhance the credibility of Indian healthcare system, procurement and delivery systems of essential medicines have to be strengthened through government commitment, careful selection, adequate public sector financing, efficient distribution systems, control on taxes and duties, and inculcating a culture of rational use of medicines in current and future prescribers. PMID:26435594

  1. Essential oils and anxiolytic aromatherapy.

    PubMed

    Setzer, William N

    2009-09-01

    A number of essential oils are currently in use as aromatherapy agents to relieve anxiety, stress, and depression. Popular anxiolytic oils include lavender (Lavandula angustifolia), rose (Rosa damascena), orange (Citrus sinensis), bergamot (Citrus aurantium), lemon (Citrus limon), sandalwood (Santalum album), clary sage (Salvia sclarea), Roman chamomile (Anthemis nobilis), and rose-scented geranium (Pelargonium spp.). This review discusses the chemical constituents and CNS effects of these aromatherapeutic essential oils, as well as recent studies on additional essential oils with anxiolytic activities. PMID:19831048

  2. TRANSPORT AND EMPLACEMENT EQUIPMENT DESCRIPTIONS

    SciTech Connect

    NA

    1997-09-29

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) Transport and Emplacement in the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. The Transport and Emplacement equipment described in this document consists of the following: (1) WP Transporter; (2) Reusable Rail Car; (3) Emplacement Gantry; (4) Gantry Carrier; and (5) Transport Locomotive.

  3. 14 CFR 121.341 - Equipment for operations in icing conditions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... equipped with means for the prevention or removal of ice on windshields, wings, empennage, propellers, and... otherwise determining the formation of ice on the parts of the wings that are critical from the standpoint... functioning deicing anti-icing equipment protecting each propeller, windshield, wing, stabilizing or...

  4. 14 CFR 121.341 - Equipment for operations in icing conditions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... equipped with means for the prevention or removal of ice on windshields, wings, empennage, propellers, and... otherwise determining the formation of ice on the parts of the wings that are critical from the standpoint... functioning deicing anti-icing equipment protecting each propeller, windshield, wing, stabilizing or...

  5. Water-Using Equipment: Domestic

    SciTech Connect

    Solana, Amy E.; Mcmordie, Katherine

    2006-01-24

    Water management is an important aspect of energy engineering. This article addresses water-using equipment primarily used for household purposes, including faucets, showers, toilets, urinals, dishwashers, and clothes washers, and focuses on how the equipment can be optimized to save both water and energy. Technology retrofits and operation and maintenance changes are the primary methods discussed for water and energy conservation. Auditing to determine current consumption rates is also described for each technology.

  6. Rig safety depends on equipment, regulations, and personnel

    SciTech Connect

    Bates, T.R. Jr.; Tait, S. ); Mumford, G. )

    1990-03-05

    The authors discuss how improvements that can increase rig safety can be made in equipment, regulations, and stabilized personnel levels. With regard to equipment, exposure to material handling must be reduced through automation, and well-control technology must be improved by enhanced use of computers and better systems to handle gas. According to this analysis, regulations are needed that are global in scope and have had their costs-to-benefits fully and fairly assessed. Self regulation must be used effectively throughout the industry. Job security and wages should be made adequate to maintain an experienced, motivated, and safe work force.

  7. Essentialism: Common Sense Quality Improvement.

    ERIC Educational Resources Information Center

    Wallin, Desna L.; Ryan, John R.

    Essentialism is a trimmed down, action-oriented, user-friendly approach to Total Quality Management (TQM) in education. This book explores the concept of essentialism to describe strategies for implementing TQM in community colleges. Chapter 1 examines the history of the TQM movement and reviews experiences of community college practitioners

  8. Recommended Minimal Emergency Equipment and Resources for Schools: National Consensus Group Report

    ERIC Educational Resources Information Center

    Bobo, Nichole; Hallenbeck, Paula; Robinson, Judith

    2003-01-01

    Providing an environment that is responsive to emergency health needs of students is essential to creating a safe setting for children in schools. The question of what minimal essential emergency equipment and resources should be available in schools brings with it many and varied opinions, issues, and concerns. Through funding from the Emergency

  9. Membrane stabilizer

    DOEpatents

    Mingenbach, W.A.

    1988-02-09

    A device is provided for stabilizing a flexible membrane secured within a frame, wherein a plurality of elongated arms are disposed radially from a central hub which penetrates the membrane, said arms imposing alternately against opposite sides of the membrane, thus warping and tensioning the membrane into a condition of improved stability. The membrane may be an opaque or translucent sheet or other material. 10 figs.

  10. Hyperbaric intensive care technology and equipment.

    PubMed

    Millar, Ian L

    2015-03-01

    In an emergency, life support can be provided during recompression or hyperbaric oxygen therapy using very basic equipment, provided the equipment is hyperbaric-compatible and the clinicians have appropriate experience. For hyperbaric critical care to be provided safely on a routine basis, however, a great deal of preparation and specific equipment is needed, and relatively few facilities have optimal capabilities at present. The type, size and location of the chamber are very influential factors. Although monoplace chamber critical care is possible, it involves special adaptations and inherent limitations that make it inappropriate for all but specifically experienced teams. A large, purpose-designed chamber co-located with an intensive care unit is ideal. Keeping the critically ill patient on their normal bed significantly improves quality of care where this is possible. The latest hyperbaric ventilators have resolved many of the issues normally associated with hyperbaric ventilation, but at significant cost. Multi-parameter monitoring is relatively simple with advanced portable monitors, or preferably installed units that are of the same type as used elsewhere in the hospital. Whilst end-tidal CO? readings are changed by pressure and require interpretation, most other parameters display normally. All normal infusions can be continued, with several examples of syringe drivers and infusion pumps shown to function essentially normally at pressure. Techniques exist for continuous suction drainage and most other aspects of standard critical care. At present, the most complex life support technologies such as haemofiltration, cardiac assist devices and extra-corporeal membrane oxygenation remain incompatible with the hyperbaric environment. PMID:25964040

  11. Equipment Efficiency for Healthy School Meals. [Videotape].

    ERIC Educational Resources Information Center

    National Food Service Management Inst., University, MS.

    A satellite seminar on large-scale food production equipment discusses ways child nutrition personnel can maximize use of existing equipment, considers research related to use of existing equipment, explains plan reviews for equipment selection and purchase, and explores new equipment options. Examples illustrate use of planning or modernizing

  12. 1968 Listing of Swimming Pool Equipment.

    ERIC Educational Resources Information Center

    National Sanitation Foundation, Ann Arbor, MI. Testing Lab.

    An up-to-date listing of swimming pool equipment including--(1) companies authorized to display the National Sanitation Foundation seal of approval, (2) equipment listed as meeting NSF swimming pool equipment standards relating to diatomite type filters, (3) equipment listed as meeting NSF swimming pool equipment standard relating to sand type…

  13. 14 CFR 25.1415 - Ditching equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Ditching equipment. 25.1415 Section 25.1415 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Safety Equipment 25.1415 Ditching equipment. (a) Ditching equipment used in airplanes...

  14. 1968 Listing of Swimming Pool Equipment.

    ERIC Educational Resources Information Center

    National Sanitation Foundation, Ann Arbor, MI. Testing Lab.

    An up-to-date listing of swimming pool equipment including--(1) companies authorized to display the National Sanitation Foundation seal of approval, (2) equipment listed as meeting NSF swimming pool equipment standards relating to diatomite type filters, (3) equipment listed as meeting NSF swimming pool equipment standard relating to sand type

  15. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  16. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  17. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  18. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  19. 14 CFR 121.345 - Radio equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Radio equipment. 121.345 Section 121.345..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.345 Radio equipment. (a) No person may operate an airplane unless it is equipped with radio equipment required for the kind...

  20. 10 CFR 431.405 - Exported equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... for export from the United States (or such equipment was imported for export), unless such equipment... 10 Energy 3 2010-01-01 2010-01-01 false Exported equipment. 431.405 Section 431.405 Energy... EQUIPMENT General Provisions § 431.405 Exported equipment. Under Sections 330 and 345 of the Act, this...

  1. 10 CFR 431.405 - Exported equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... for export from the United States (or such equipment was imported for export), unless such equipment... 10 Energy 3 2011-01-01 2011-01-01 false Exported equipment. 431.405 Section 431.405 Energy... EQUIPMENT General Provisions § 431.405 Exported equipment. Under Sections 330 and 345 of the Act, this...

  2. Preparation and characterization of clove essential oil-loaded liposomes.

    PubMed

    Sebaaly, Carine; Jraij, Alia; Fessi, Hatem; Charcosset, Catherine; Greige-Gerges, Hlne

    2015-07-01

    In this study, suitable formulations of natural soybean phospholipid vesicles were developed to improve the stability of clove essential oil and its main component, eugenol. Using an ethanol injection method, saturated (Phospholipon 80H, Phospholipon 90H) and unsaturated soybean (Lipoid S100) phospholipids, in combination with cholesterol, were used to prepare liposomes at various eugenol and clove essential oil concentrations. Liposomal batches were characterized and compared for their size, polydispersity index, Zeta potential, loading rate, encapsulation efficiency and morphology. The liposomes were tested for their stability after storing them for 2 months at 4C by monitoring changes in their mean size, polydispersity index and encapsulation efficiency (EE) values. It was found that liposomes exhibited nanometric oligolamellar and spherical shaped vesicles and protected eugenol from degradation induced by UV exposure; they also maintained the DPPH-scavenging activity of free eugenol. Liposomes constitute a suitable system for encapsulation of volatile unstable essential oil constituents. PMID:25704683

  3. Neuroimaging essentials in essential tremor: A systematic review

    PubMed Central

    Sharifi, Sarvi; Nederveen, Aart J.; Booij, Jan; vanRootselaar, Anne-Fleur

    2014-01-01

    Background Essential tremor is regarded to be a disease of the central nervous system. Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and research. The exact role of imaging techniques with respect to essential tremor in research and clinical practice is not clear. A systematic review of the different imaging techniques in essential tremor is lacking in the literature. Methods We performed a systematic literature search combining the terms essential tremor and familial tremor with the following keywords: imaging, MRI, VBM, DWI, fMRI, PET and SPECT, both in abbreviated form as well as in full form. We summarize and discuss the quality and the external validity of each study and place the results in the context of existing knowledge regarding the pathophysiology of essential tremor. Results A total of 48 neuroimaging studies met our search criteria, roughly divided into 19 structural and 29 functional and metabolic studies. The quality of the studies varied, especially concerning inclusion criteria. Functional imaging studies indicated cerebellar hyperactivity during rest and during tremor. The studies also pointed to the involvement of the thalamus, the inferior olive and the red nucleus. Structural studies showed less consistent results. Discussion and conclusion Neuroimaging techniques in essential tremor give insight into the pathophysiology of essential tremor indicating the involvement of the cerebellum as the most consistent finding. GABAergic dysfunction might be a major premise in the pathophysiological hypotheses. Inconsistencies between studies can be partly explained by the inclusion of heterogeneous patient groups. Improvement of scientific research requires more stringent inclusion criteria and application of advanced analysis techniques. Also, the use of multimodal neuroimaging techniques is a promising development in movement disorders research. Currently, the role of imaging techniques in essential tremor in daily clinical practice is limited. PMID:25068111

  4. Stabilizing Microwave Frequency of a Photonic Oscillator

    NASA Technical Reports Server (NTRS)

    Maleki, Lute; Yu, Nan; Tu, Meirong

    2006-01-01

    A scheme for stabilizing the frequency of a microwave signal is proposed that exploits the operational characteristics of a coupled optoelectronic oscillator (COEO) and related optoelectronic equipment. An essential element in the scheme is a fiber mode-locked laser (MLL), the optical frequency of which is locked to an atomic transition. In this scheme, the optical frequency stability of the mode-locked laser is transferred to that of the microwave in the same device. Relative to prior schemes for using wideband optical frequency comb to stabilize microwave signals, this scheme is simpler and lends itself more readily to implementation in relatively compact, rugged equipment. The anticipated development of small, low-power, lightweight, highly stable microwave oscillators based on this scheme would afford great benefits in communication, navigation, metrology, and fundamental sciences. COEOs of various designs, at various stages of development, in some cases called by different names, have been described in a number of prior NASA Tech Briefs articles. A COEO is an optoelectronic apparatus that generates both short (picosecond) optical pulses and a steady microwave signal having an ultrahigh degree of spectral purity. The term "coupled optoelectronic" in the full name of such an apparatus signifies that its optical and electronic oscillations are coupled to each other in a single device. The present frequency-stabilization scheme is best described indirectly by describing the laboratory apparatus used to demonstrate it. The apparatus (see figure) includes a COEO that generates a comb-like optical spectrum, the various frequency components of which interfere, producing short optical pulses. This spectrum is centered at a nominal wavelength of 1,560 nm. The spectrum separation of this comb is about 10 GHz, as determined primarily by the length of an optical loop and the bandpass filter in the microwave feedback loop. The optical loop serves as microwave resonator having a very high value of the resonance quality factor (Q). The optical frequency of MLL is then stabilized by locking it to an atomic transition as described below. The COEO contains a tunable 1-nm band-pass optical filter and a piezoelectric-transducer (PZT) drum over which a stretch of fiber is wound. The 1-nm-wide pass band of the filter provides coarse tuning to overlap the frequency comb with the atomic transition frequency. Controlled stretching of the fiber by means of the PZT drum can be used in conjunction with temperature control for locking the laser frequency. To reference to an atomic resonance at 780 nm in this demonstration setup, the optical output of the COEO at 1,560 nm is fed through an erbium-doped-fiber amplifier (EDFA) to a frequency doubler in the form of a periodically poled lithium niobate (PPLN) crystal. The frequency-doubled output is combined with the output of a separate frequency-stabilized diode laser at a photodetector. As described thus far, the two 780-nm laser subsystems are nominally independent of each other and can, therefore, operate at different frequencies. Hence, at the photodetector, the two laser beams interfere, so that the output of the photodetector includes a beat note (a component at the difference between the two laser frequencies).

  5. Stability of large-scale systems.

    NASA Technical Reports Server (NTRS)

    Siljak, D. D.

    1972-01-01

    The purpose of this paper is to present the results obtained in stability study of large-scale systems based upon the comparison principle and vector Liapunov functions. The exposition is essentially self-contained, with emphasis on recent innovations which utilize explicit information about the system structure. This provides a natural foundation for the stability theory of dynamic systems under structural perturbations.

  6. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a medicated feed of intended potency and purity, and shall...

  7. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a medicated feed of intended potency and purity, and shall...

  8. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a medicated feed of intended potency and purity, and shall...

  9. The choice of homogenisation equipment affects lipid oxidation in emulsions.

    PubMed

    Horn, Anna Frisenfeldt; Nielsen, Nina Skall; Jensen, Louise Søgaard; Horsewell, Andy; Jacobsen, Charlotte

    2012-09-15

    Milk proteins are often used by the food industry because of their good emulsifying properties. In addition, they can also provide oxidative stability to foods. However, different milk proteins or protein components have been shown to differ in their antioxidative properties, and their localisation in emulsions has been shown to be affected by the emulsification conditions. The objective of this study was to investigate the influence of homogenisation equipment (microfluidizer vs. two-stage valve homogeniser) on lipid oxidation in 10% fish oil-in-water emulsions prepared with two different milk proteins. Emulsions were prepared at pH 7 with similar droplet sizes. Results showed that the oxidative stability of emulsions prepared with sodium caseinate was not influenced by the type of homogeniser used. In contrast, the type of homogenisation equipment significantly influenced lipid oxidation when whey protein was used as emulsifier, with the microfluidizer resulting in lower levels of oxidation. PMID:23107694

  10. Genetics Home Reference: Essential thrombocythemia

    MedlinePLUS

    ... Platelets (thrombocytes) are blood cell fragments involved in blood clotting. While some people with this condition have no ... develop problems associated with the excess platelets. Abnormal blood clotting (thrombosis) is common in people with essential thrombocythemia ...

  11. Aromatherapy and Essential Oils (PDQ)

    MedlinePLUS

    ... Cancer & Caregivers Managing Cancer Care Finding Health Care Services Advance ... of years across many cultures, including ancient China, India, and Egypt. Ways to extract essential oils from plants were ...

  12. Essential Elements of Geologic Reports.

    ERIC Educational Resources Information Center

    Webb, Elmer James

    1988-01-01

    Described is a report outline for geologic reports. Essential elements include title; abstract; introduction; stratigraphy; petrography; geochemistry; petrology; geophysics; structural geology; geologic history; modeling; economics; conclusions; and recommendations. (Author/CW)

  13. Genetics Home Reference: Essential pentosuria

    MedlinePLUS

    ... and Families Resources for Health Professionals What glossary definitions help with understanding essential pentosuria? Ashkenazi Jewish ; autosomal ; ... 22, 2016 Lister Hill National Center for Biomedical Communications U.S. National Library of Medicine , National Institutes of ...

  14. Essential Oils, Part I: Introduction.

    PubMed

    de Groot, Anton C; Schmidt, Erich

    2016-01-01

    Essential oils are widely used in the flavor, food, fragrance, and cosmetic industries in many applications. Contact allergy to them is well known and has been described for 80 essential oils. The relevance of positive patch test reactions often remains unknown. Knowledge of the chemical composition of essential oils among dermatologists is suspected to be limited, as such data are published in journals not read by the dermatological community. Therefore, the authors have fully reviewed and published the literature on contact allergy to and chemical composition of essential oils. Selected topics from this publication will be presented in abbreviated form in Dermatitis starting with this issue, including I. Introduction; II. General aspects; III. Chemistry; IV. General aspects of contact allergy; V. Peppermint oil, lavender oil and lemongrass oil; VI: Sandalwood oil, ylang-ylang oil, and jasmine absolute. PMID:26983089

  15. Genetics Home Reference: Essential tremor

    MedlinePLUS

    ... can also occur when the muscles are opposing gravity, such as when the hands are extended. It ... in the Handbook. What if I still have specific questions about essential tremor? Ask the Genetic and ...

  16. A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

    PubMed Central

    Zhang, Y. Ping; Shields, Lisa B. E.; Shields, Christopher B.; Xu, Xiao-Ming

    2015-01-01

    Clinically-relevant animal cervical spinal cord injury (SCI) models are essential for developing and testing potential therapies; however, producing reliable cervical SCI is difficult due to lack of satisfactory methods of vertebral stabilization. The conventional method to stabilize the spine is to suspend the rostral and caudal cervical spine via clamps attached to cervical spinous processes. However, this method of stabilization fails to prevent tissue yielding during the contusion as the cervical spinal processes are too short to be effectively secured by the clamps (Figure 1). Here we introduce a new method to completely stabilize the cervical vertebra at the same level of the impact injury. This method effectively minimizes movement of the spinal column at the site of impact, which greatly improves the production of consistent SCIs. We provide visual description of the equipment (Figure 2-4), methods, and a step-by-step protocol for the stabilization of the cervical 5 vertebra (C5) of adult rats, to perform laminectomy (Figure 5) and produce a contusive SCI thereafter. Although we only demonstrate a cervical hemi-contusion using the NYU/MASCIS impactor device, this vertebral stabilization technique can be applied to other regions of the spinal cord, or be adapted to other SCI devices. Improving spinal cord exposure and fixation through vertebral stabilization may be valuable for producing consistent and reliable injuries to the spinal cord. This vertebral stabilization method can also be used for stereotactic injections of cells and tracers, and for imaging using two-photon microscopy in various neurobiological studies. PMID:25590284

  17. A novel vertebral stabilization method for producing contusive spinal cord injury.

    PubMed

    Walker, Melissa J; Walker, Chandler L; Zhang, Y Ping; Shields, Lisa B E; Shields, Christopher B; Xu, Xiao-Ming

    2015-01-01

    Clinically-relevant animal cervical spinal cord injury (SCI) models are essential for developing and testing potential therapies; however, producing reliable cervical SCI is difficult due to lack of satisfactory methods of vertebral stabilization. The conventional method to stabilize the spine is to suspend the rostral and caudal cervical spine via clamps attached to cervical spinous processes. However, this method of stabilization fails to prevent tissue yielding during the contusion as the cervical spinal processes are too short to be effectively secured by the clamps (Figure 1). Here we introduce a new method to completely stabilize the cervical vertebra at the same level of the impact injury. This method effectively minimizes movement of the spinal column at the site of impact, which greatly improves the production of consistent SCIs. We provide visual description of the equipment (Figure 2-4), methods, and a step-by-step protocol for the stabilization of the cervical 5 vertebra (C5) of adult rats, to perform laminectomy (Figure 5) and produce a contusive SCI thereafter. Although we only demonstrate a cervical hemi-contusion using the NYU/MASCIS impactor device, this vertebral stabilization technique can be applied to other regions of the spinal cord, or be adapted to other SCI devices. Improving spinal cord exposure and fixation through vertebral stabilization may be valuable for producing consistent and reliable injuries to the spinal cord. This vertebral stabilization method can also be used for stereotactic injections of cells and tracers, and for imaging using two-photon microscopy in various neurobiological studies. PMID:25590284

  18. Remote welding equipment for TPX

    SciTech Connect

    Silke, G.W.; Junge, R.

    1995-12-31

    Remote welding equipment and techniques are necessary for maintenance of the Tokamak Physics Experiment (TPX) Plasma Facing Components (PFCs). The processes identified for this application includes inside diameter (i.d.) and outside diameter (o.d.) Gas Tungsten Arc (GTA) welding of titanium and stainless steel alloys. Welding equipment developed for this application includes some unique features due to the specialized environment of the TPX vessel. Remote features of this equipment must include the ability to acquire and align the parts being welded, perform all welding operations and visually inspect the weld area. Designs for weld heads require the integration of industry proven hardware with the special features include compact size, remote manipulation, remote clamping and alignment, remote vision, full inert gas coverage, arc voltage control, wire feed, programmable weld schedules and failure recovery.

  19. Power Product Equipment Technician: Construction Equipment. Teacher Edition. Student Edition.

    ERIC Educational Resources Information Center

    Hilley, Robert

    The instructor's guide in this package, which is one in a series of new publications developed to replace the Multistate Academic and Vocational Curriculum Consortium's previous small-engine curricula, contains the materials required to teach a competency-based course in repairing construction equipment. The guide begins with an introduction

  20. Power Product Equipment Technician: Construction Equipment. Teacher Edition. Student Edition.

    ERIC Educational Resources Information Center

    Hilley, Robert

    The instructor's guide in this package, which is one in a series of new publications developed to replace the Multistate Academic and Vocational Curriculum Consortium's previous small-engine curricula, contains the materials required to teach a competency-based course in repairing construction equipment. The guide begins with an introduction…

  1. Heavy Equipment Operator: General Equipment Operator. Instructional Materials.

    ERIC Educational Resources Information Center

    Hendrix, Laborn J.; Sawatzky, Joyce

    Developed through close coordination between contractors, construction workers, and vocational educators, this instructor's manual is designed to help heavy equipment instructors present materials in a systematic format. The instructional materials in the manual are written in terms of student performance, using measurable behavioral objectives.

  2. Essential Spaceflight Dynamics and Magnetospherics

    NASA Astrophysics Data System (ADS)

    Rauschenbakh, B. V.; Ovchinnikov, M. Yu.; McKenna-Lawlor, S.

    2002-12-01

    The present book Essential Spaceflight Dynamics and Magnetospherics describes, in the first instance, some of the key aspects of celestial mechanics and spaceflight dynamics. It begins with classical two- and three-body problems illustrative of the aesthetic aspects of applying analytical methods of investigation to celestial mechanics. Then, osculating orbital elements are introduced as well as analysis techniques sufficient to evaluate the influence of various disturbing forces on spacecraft. Next a theory of manoeuvres is outlined and the methodology of making interplanetary trajectory corrections. Ideas involving various approaches to orbital element determinations using measured data are also considered. The forces applied to a spacecraft can result in the development of torques that influence attitude motion and the effects of the most important of these are described in terms of equilibrium positions, periodic motions, steady-state and transient motions. Also considered is the problem of attitude control of a spacecraft using active and/or passive methods of orientation and stabilization. In addition, a more advanced treatment of the development of attitude control systems is provided. A description of the Earth's magnetic and gravitational fields allows clarification of the relationship between natural features of the Earth's environment and the requirements of mission design, orbit construction and approaches to attitude control. A detailed Addendum provides an overview of circumstances on the Sun that render interplanetary space a very hazardous environment for spacecraft and for `man in space'. The influence of this environment on spacecraft performance and survival is then presented, together with an outline of some of the mitigating strategies that can be invoked. A feature of this Addendum is the indication it provides of the challenges that the next generation of space experiments will pose to mission designers. It is accompanied by a separate set of references since if refers to ongoing work in space physics rather than to classical material. Rauschenbakh, Boris Victorovich (1915-2001). Doctor of Technical Science, Member of the Russian Academy of Sciences and the International Academy of Astronautics. One of the founders of practical cosmonautics in Russia. Worked in the `Energia' Enterprise with Sergey Koroljev and later occupied the Chair of Theoretical Mechanics at the Moscow Institute of Physics and Technology. Ovchinnikov, Michael Yurjevich, Doctor of Science in Physics and Mathematics at the Keldysh Institute of Applied Mathematics of the Russian Academy of Sciences and also a Professor at the Moscow Institute of Physics and Technology. Expert in mechanics, spaceflight dynamics and attitude control for small satellites. McKenna-Lawlor, Susan, Emeritus Professor at the National University of Ireland, Maynooth. Guest Professor of the Chinese Academy of Sciences. Doctorate in Space Physics. Director of Space Technology Ireland, Ltd. Pioneering experiments flown on European, American, Russian and Chinese Space Agency Missions. Member of the International Academy of Astronautics. Recipient of the Tsiolkovsky Medal for Cosmonautics. Link: http://www.wkap.nl/prod/b/1-4020-1063-X

  3. Astronaut Alan Bean flies the Astronaut Maneuvering Equipment

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Astronaut Alan L. Bean, Skylab 3 commander, flies the M509 Astronaut Maneuvering Equipment in the forward dome area of the Orbital Workshop (OWS) on the space station cluster in Earth orbit. Bean is strapped in to the back-mounted, hand-controlled Automatically Stabilized Maneuvering Unit (ASMU). This ASMU exerperiment is being done in shirt sleeves. The dome area where the experiment is conducted is about 22 feet in diameter and 19 feet from top to bottom.

  4. Astronaut Alan Bean flies the Astronaut Maneuvering Equipment

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Astronaut Alan L. Bean, Skylab 3 commander, flies the M509 Astronaut Maneuvering Equipment in the foreward dome area of the Orbital Workshop (OWS) on the space station cluster in Earth orbit. Bean is strapped in to the back-mounted, hand-controlled Automatically Stabilized Maneuvering Unit (ASMU). This ASMU exerperiment is being done in shirt sleeves. The dome area where the experiment is conducted is about 22 feet in diameter and 19 feet from top to bottom.

  5. Shuttle extravehicular life support equipment

    NASA Technical Reports Server (NTRS)

    Sutton, J. G.

    1973-01-01

    A Shuttle EVA/IVA Requirements Study was conducted by Hamilton Standard for NASA. The objectives of this study were to establish a baseline EVA approach for Shuttle and to prepare requirements for the EVA equipment required to support these operations. This paper presents the results of the EVA life support requirements definition effort and defines candidate configurations which meet these requirements. Various subsystem and system concepts were identified and evaluated to determine the most desirable approaches. Both independent and umbilical configurations are considered. Because certain EVA missions could involve contamination-sensitive payloads, the impact of integrating noncontaminating equipment is also considered.

  6. Advanced deep sea diving equipment

    NASA Technical Reports Server (NTRS)

    Danesi, W. A.

    1972-01-01

    Design requirements are generated for a deep sea heavy duty diving system to equip salvage divers with equipment and tools that permit work of the same quality and in times approaching that done on the surface. The system consists of a helmet, a recirculator for removing carbon dioxide, and the diver's dress. The diver controls the inlet flow by the recirculatory control valve and is able to change closed cycle operation to open cycle if malfunction occurs. Proper function of the scrubber in the recirculator minimizes temperature and humidity effects as it filters the returning air.

  7. Equipment

    ERIC Educational Resources Information Center

    Education in Chemistry, 1976

    1976-01-01

    Described are a number of publications and items for use in chemistry. Included are brief descriptions of actuators, thermometer strips, current balances, and a variety of catalogues and other publications. (RH)

  8. 46 CFR 173.020 - Intact stability standards: Counterballasted and non-counterballasted vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSEL USE Lifting 173.020 Intact stability standards... vessel that is not equipped to counter-ballast while lifting must be shown by design calculations...

  9. 46 CFR 173.020 - Intact stability standards: Counterballasted and non-counterballasted vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSEL USE Lifting 173.020 Intact stability standards... vessel that is not equipped to counter-ballast while lifting must be shown by design calculations...

  10. 46 CFR 173.020 - Intact stability standards: Counterballasted and non-counterballasted vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSEL USE Lifting 173.020 Intact stability standards... vessel that is not equipped to counter-ballast while lifting must be shown by design calculations...

  11. 46 CFR 173.020 - Intact stability standards: Counterballasted and non-counterballasted vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSEL USE Lifting 173.020 Intact stability standards... vessel that is not equipped to counter-ballast while lifting must be shown by design calculations...

  12. The doctrinal basis for medical stability operations.

    PubMed

    Baker, Jay B

    2010-01-01

    This article describes possible roles for the military in the health sector during stability operations, which exist primarily when security conditions do not permit the free movement of civilian actors. This article reviews the new U.S. Army Field Manuals (FMs) 3-24, Counterinsurgency and FM 3-07, Stability Operations, in the context of the health sector. Essential tasks in medical stability operations are identified for various logical lines of operation including information operations, civil security, civil control, support to governance, support to economic development, and restoration of essential services. Restoring essential services is addressed in detail including coordination, assessment, actions, and metrics in the health sector. Coordination by the military with other actors in the health sector including host nation medical officials, other United States governmental agencies, international governmental organizations (IGOs), and nongovernment organizations (NGOs) is key to success in medical stability operations. PMID:20108837

  13. Hybridoma stability.

    PubMed

    Castillo, F J; Mullen, L J; Grant, B C; DeLeon, J; Thrift, J C; Chang, L W; Irving, J M; Burke, D J

    1994-01-01

    Hybridoma stability issues include mutations, chromosome losses, and the potential effects of process variables on the yield, quality and homogeneity of the Monoclonal Antibody (MAb) product. MAb production by murine hybridomas is typically unstable in the early stages after fusion but repeated cloning normally produces stable clones. The stability of hybridomas and the consistency of the MAbs produced during extended high density perfusion cultures at Xoma Corporation were evaluated. Cell stability was assessed by recovering cells from the bioreactors at different intervals and comparing their growth and product formation kinetics and yields to those of cells started fresh from the corresponding Manufacturer's Working Cell Banks. Product consistency was evaluated in the crude harvests and in the corresponding purified MAb lots by biochemical and functionality tests including: SDS-PAGE (reducing and non-reducing), IEF, HPLC (size exclusion and cation exchange), peptide mapping, N-terminal sequencing, carbohydrate composition and binding assays. Several murine hybridomas were studied during runs lasting several months and found to be stable by all criteria employed. Such results support the viability of extended hollow fiber perfusion cultures for reproducible production of murine MAbs. Selecting stable clones and understanding the effects of process variables on the quantity and quality of the MAbs are keys to controlling hybridoma stability during the manufacturing process. PMID:7533731

  14. Multimedia Equipment for Distance Education.

    ERIC Educational Resources Information Center

    Schiller, Scott S.

    1993-01-01

    Discusses the use of multimedia equipment for distance education. Topics addressed include use of the Internet; distance learning for educators; and cable television and/or fiber optics, including interactive television and satellite technology. A sidebar lists online and telecommunications providers. (LRW)

  15. Housing, Home Furnishings, and Equipment.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    Designed for use in consumer and homemaking education in Texas, this curriculum guide is on the subject of housing, home furnishings, and equipment. An introduction to the guide, covering its use and program and curriculum planning, provides a list of suggested readings. Information on teaching handicapped and disadvantaged students follows. The…

  16. Preventive Maintenance Handbook. Audiovisual Equipment.

    ERIC Educational Resources Information Center

    Educational Products Information Exchange Inst., Stony Brook, NY.

    The preventive maintenance system for audiovisual equipment presented in this handbook is designed by specialists so that it can be used by nonspecialists in school sites. The report offers specific advice on saftey factors and also lists major problems that should not be handled by nonspecialists. Other aspects of a preventive maintenance system…

  17. Heating and Cooling Equipment Selection

    SciTech Connect

    Not Available

    2002-01-01

    This is one of a series of technology fact sheets created to help housing designers and builders adopt a whole-house design approach and energy efficient design practices. The fact sheet helps people choose the correct equipment for heating and cooling to reduce initial costs, increase homeowner comfort, increase operating efficiency, and greatly reduce utility costs.

  18. Using Gaming Equipment to Teach

    ERIC Educational Resources Information Center

    Curriculum Review, 2009

    2009-01-01

    Gaming equipment (such as Nintendo's Wii[TM]) is making its way to schools and classrooms. However, most of the discussion regarding how to use this technology and integrate it into lesson plans is happening in blogs on the Internet. An advocate of interactive media in the classroom, Dr. Dawn Hawkins, a faculty member for the Art Institute of

  19. Preventive Maintenance Handbook. Audiovisual Equipment.

    ERIC Educational Resources Information Center

    Educational Products Information Exchange Inst., Stony Brook, NY.

    The preventive maintenance system for audiovisual equipment presented in this handbook is designed by specialists so that it can be used by nonspecialists in school sites. The report offers specific advice on saftey factors and also lists major problems that should not be handled by nonspecialists. Other aspects of a preventive maintenance system

  20. Lawn and Garden Equipment Repair.

    ERIC Educational Resources Information Center

    Hardway, Jack; And Others

    This publication is designed to supplement the Comprehensive Small Engine Rapair guide by covering in detail all aspects of lawn and garden equipment repair not included in general engine repair or the repair of other small engines. It consists of instructional materials for both teachers and students, written in terms of student performance using

  1. Housing, Home Furnishings, and Equipment.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    Designed for use in consumer and homemaking education in Texas, this curriculum guide is on the subject of housing, home furnishings, and equipment. An introduction to the guide, covering its use and program and curriculum planning, provides a list of suggested readings. Information on teaching handicapped and disadvantaged students follows. The

  2. Strategy Guideline. HVAC Equipment Sizing

    SciTech Connect

    Burdick, Arlan

    2012-02-01

    This guide describes the equipment selection of a split system air conditioner and furnace for an example house in Chicago, IL as well as a heat pump system for an example house in Orlando, FL. The required heating and cooling load information for the two example houses was developed in the Department of Energy Building America Strategy Guideline: Accurate Heating and Cooling Load Calculations.

  3. Cultural transmission of social essentialism

    PubMed Central

    Rhodes, Marjorie; Leslie, Sarah-Jane; Tworek, Christina M.

    2012-01-01

    Social essentialism entails the belief that certain social categories (e.g., gender, race) mark fundamentally distinct kinds of people. Essentialist beliefs have pernicious consequences, supporting social stereotyping and contributing to prejudice. How does social essentialism develop? In the studies reported here, we tested the hypothesis that generic language facilitates the cultural transmission of social essentialism. Two studies found that hearing generic language about a novel social category diverse for race, ethnicity, age, and sex led 4-y-olds and adults to develop essentialist beliefs about that social category. A third study documented that experimentally inducing parents to hold essentialist beliefs about a novel social category led them to produce more generic language when discussing the category with their children. Thus, generic language facilitates the transmission of essentialist beliefs about social categories from parents to children. PMID:22869722

  4. 14 CFR 91.513 - Emergency equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Emergency equipment. 91.513 Section 91.513... Airplanes and Fractional Ownership Program Aircraft § 91.513 Emergency equipment. (a) No person may operate an airplane unless it is equipped with the emergency equipment listed in this section. (b) Each...

  5. 14 CFR 91.513 - Emergency equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Emergency equipment. 91.513 Section 91.513... Airplanes and Fractional Ownership Program Aircraft § 91.513 Emergency equipment. (a) No person may operate an airplane unless it is equipped with the emergency equipment listed in this section. (b) Each...

  6. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false Equipment design. 792.61 Section 792.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Equipment 792.61 Equipment design. Equipment used in...

  7. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Equipment design. 792.61 Section 792.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Equipment 792.61 Equipment design. Equipment used in...

  8. 46 CFR 108.701 - Sounding equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Sounding equipment. 108.701 Section 108.701 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment 108.701 Sounding equipment. Each self-propelled unit must have...

  9. 10 CFR 431.404 - Imported equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Imported equipment. 431.404 Section 431.404 Energy... EQUIPMENT General Provisions 431.404 Imported equipment. (a) Under sections 331 and 345 of the Act, any person importing any covered equipment into the United States must comply with the provisions of the...

  10. 46 CFR 108.701 - Sounding equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Sounding equipment. 108.701 Section 108.701 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment 108.701 Sounding equipment. Each self-propelled unit must have a mechanical or electronic sounding...

  11. 46 CFR 108.701 - Sounding equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Sounding equipment. 108.701 Section 108.701 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment 108.701 Sounding equipment. Each self-propelled unit must have a mechanical or electronic sounding...

  12. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  13. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  14. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  15. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  16. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  17. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  18. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  19. 46 CFR 197.460 - Diving equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Diving equipment. 197.460 Section 197.460 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Periodic Tests and Inspections of Diving Equipment § 197.460 Diving equipment. The diving supervisor shall insure that the diving equipment designated for...

  20. Energy-related laboratory equipment (ERLE) guidelines

    SciTech Connect

    Not Available

    1995-01-01

    This document describes the Used Energy-Related Laboratory Equipment grants, and eligibility and procedures for participation. The document contains tables identifying typical equipment that may be requested, where to review ERLE equipment lists, and where to mail applications, a description of the eligible equipment grants access data system, and a copy of the ERLE grant application and instructions for its completion and submission.

  1. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Electronic equipment. 25.1431 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Miscellaneous Equipment § 25.1431 Electronic equipment. (a) In showing compliance with § 25.1309 (a) and (b) with respect to radio and...

  2. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. (a) In showing compliance with § 23.1309(a), (b), and (c) with respect to radio and electronic equipment and their installations, critical environmental conditions...

  3. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Electronic equipment. 25.1431 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Miscellaneous Equipment § 25.1431 Electronic equipment. (a) In showing compliance with § 25.1309 (a) and (b) with respect to radio and...

  4. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Electronic equipment. 25.1431 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Miscellaneous Equipment § 25.1431 Electronic equipment. (a) In showing compliance with § 25.1309 (a) and (b) with respect to radio and...

  5. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. (a) In showing compliance with § 23.1309(b)(1) and (2) with respect to radio and electronic equipment and their installations, critical environmental conditions...

  6. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. (a) In showing compliance with § 23.1309(b)(1) and (2) with respect to radio and electronic equipment and their installations, critical environmental conditions...

  7. 14 CFR 25.1431 - Electronic equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Electronic equipment. 25.1431 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Miscellaneous Equipment § 25.1431 Electronic equipment. (a) In showing compliance with § 25.1309 (a) and (b) with respect to radio and...

  8. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. (a) In showing compliance with § 23.1309(a), (b), and (c) with respect to radio and electronic equipment and their installations, critical environmental conditions...

  9. 14 CFR 29.1415 - Ditching equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Ditching equipment. 29.1415 Section 29.1415 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Safety Equipment 29.1415 Ditching equipment. (a) Emergency flotation and...

  10. 29 CFR 1926.600 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Motor Vehicles, Mechanized Equipment, and Marine Operations 1926.600 Equipment. (a) General requirements. (1) All equipment left unattended at night... 29 Labor 8 2010-07-01 2010-07-01 false Equipment. 1926.600 Section 1926.600 Labor...

  11. 10 CFR 431.404 - Imported equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Imported equipment. 431.404 Section 431.404 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT General Provisions § 431.404 Imported equipment. (a) Under sections 331 and 345 of the Act, any person importing any covered equipment...

  12. 47 CFR 18.203 - Equipment authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Equipment authorization. 18.203 Section 18.203 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INDUSTRIAL, SCIENTIFIC, AND MEDICAL EQUIPMENT Applications and Authorizations § 18.203 Equipment authorization. (a) Consumer ISM equipment, unless otherwise specified, must be...

  13. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  14. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  15. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Equipment design. 792.61 Section 792... (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Equipment 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  16. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  17. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  18. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  19. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  20. 40 CFR 265.32 - Required equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... equipment, or automatic sprinklers, or water spray systems. ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Required equipment. 265.32 Section 265... FACILITIES Preparedness and Prevention § 265.32 Required equipment. All facilities must be equipped with...

  1. 40 CFR 264.32 - Required equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems. ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Required equipment. 264.32 Section 264... Preparedness and Prevention § 264.32 Required equipment. All facilities must be equipped with the...

  2. 40 CFR 264.32 - Required equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems. ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Required equipment. 264.32 Section 264... Preparedness and Prevention § 264.32 Required equipment. All facilities must be equipped with the...

  3. 40 CFR 265.32 - Required equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... equipment, or automatic sprinklers, or water spray systems. ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Required equipment. 265.32 Section 265... FACILITIES Preparedness and Prevention § 265.32 Required equipment. All facilities must be equipped with...

  4. 40 CFR 265.32 - Required equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... equipment, or automatic sprinklers, or water spray systems. ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Required equipment. 265.32 Section 265... FACILITIES Preparedness and Prevention § 265.32 Required equipment. All facilities must be equipped with...

  5. 40 CFR 264.32 - Required equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... supply water hose streams, or foam producing equipment, or automatic sprinklers, or water spray systems. ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Required equipment. 264.32 Section 264... Preparedness and Prevention § 264.32 Required equipment. All facilities must be equipped with the...

  6. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards § 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  7. 14 CFR 23.1561 - Safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety equipment. 23.1561 Section 23.1561... Markings and Placards § 23.1561 Safety equipment. (a) Safety equipment must be plainly marked as to method of operation. (b) Stowage provisions for required safety equipment must be marked for the benefit...

  8. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Equipment design. 792.61 Section 792.61...) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  9. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment § 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  10. 40 CFR 792.61 - Equipment design.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Equipment design. 792.61 Section 792... (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  11. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment § 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  12. 21 CFR 58.61 - Equipment design.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Equipment design. 58.61 Section 58.61 Food and... PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment § 58.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall...

  13. 40 CFR 160.61 - Equipment design.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment § 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably...

  14. 45 CFR 74.34 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... equipment with a current per unit fair market value of $5000 or more, the recipient may retain the equipment... the original project or program to the current fair market value of the equipment. If the recipient... project or program to the current fair market value of the equipment, plus any reasonable shipping...

  15. 21 CFR 225.30 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.30 Section 225.30 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Construction and Maintenance of Facilities and Equipment § 225.30 Equipment. (a) Equipment which...

  16. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Equipment. 225.130 Section 225.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a...

  17. 21 CFR 225.30 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Equipment. 225.30 Section 225.30 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Construction and Maintenance of Facilities and Equipment § 225.30 Equipment. (a) Equipment which...

  18. 21 CFR 225.130 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.130 Section 225.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a...

  19. 47 CFR 18.203 - Equipment authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Equipment authorization. 18.203 Section 18.203 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INDUSTRIAL, SCIENTIFIC, AND MEDICAL EQUIPMENT Applications and Authorizations 18.203 Equipment authorization. (a) Consumer ISM equipment, unless...

  20. 47 CFR 18.203 - Equipment authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Equipment authorization. 18.203 Section 18.203 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INDUSTRIAL, SCIENTIFIC, AND MEDICAL EQUIPMENT Applications and Authorizations 18.203 Equipment authorization. (a) Consumer ISM equipment, unless...

  1. 47 CFR 18.203 - Equipment authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Equipment authorization. 18.203 Section 18.203 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INDUSTRIAL, SCIENTIFIC, AND MEDICAL EQUIPMENT Applications and Authorizations 18.203 Equipment authorization. (a) Consumer ISM equipment, unless...

  2. 21 CFR 606.60 - Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Equipment. 606.60 Section 606.60 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS CURRENT GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Equipment § 606.60 Equipment. (a) Equipment used in the collection, processing,...

  3. SOLIDIFICATION/STABILIZATION - US ENVIRONMENTAL PROTECTION AGENCY SUPERFUND PROGRAM

    EPA Science Inventory

    This presentation outlines the Superfund program approach to site cleanup, then provides information from actual insitu and exsitu solidification/stabilization remediations to illustrate technology, equipment, field implementation, performance evaluation, cleanup specifications, ...

  4. Technology Demonstration Summary, Chemfix Solidification/Stabilization Process, Clackamas, Oregon

    EPA Science Inventory

    ChemfIx's* patented stabilization/solidification technology was demonstrated at the Portable Equipment Salvage Company (PESC) site in Clackamas, Oregon, as part of the Superfund Innovative Technology Evaluation (SITE) program. The Chemfix process is designed to solidify and sta...

  5. Analgesic Potential of Essential Oils.

    PubMed

    Sarmento-Neto, José Ferreira; do Nascimento, Lázaro Gomes; Felipe, Cícero Francisco Bezerra; de Sousa, Damião Pergentino

    2015-01-01

    Pain is an unpleasant sensation associated with a wide range of injuries and diseases, and affects approximately 20% of adults in the world. The discovery of new and more effective drugs that can relieve pain is an important research goal in both the pharmaceutical industry and academia. This review describes studies involving antinociceptive activity of essential oils from 31 plant species. Botanical aspects of aromatic plants, mechanisms of action in pain models and chemical composition profiles of the essential oils are discussed. The data obtained in these studies demonstrate the analgesic potential of this group of natural products for therapeutic purposes. PMID:26703556

  6. Tank farms essential drawing plan

    SciTech Connect

    Domnoske-Rauch, L.A.

    1998-08-04

    The purpose of this document is to define criteria for selecting Essential Drawings, Support Drawings, and Controlled Print File (CPF) drawings and documents for facilities that are part of East and West Tank Farms. Also, the drawings and documents that meet the criteria are compiled separate listings. The Essential Drawing list and the Support Drawing list establish a priority for updating technical baseline drawings. The CPF drawings, denoted by an asterisk (*), defined the drawings and documents that Operations is required to maintain per the TWRS Administration Manual. The Routing Boards in Buildings 272-WA and 272-AW are not part of the CPF.

  7. Protein stability: a crystallographer’s perspective

    PubMed Central

    Deller, Marc C.; Kong, Leopold; Rupp, Bernhard

    2016-01-01

    Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food industries, in addition to being a daily consideration for academic researchers studying proteins. An understanding of protein stability is essential for optimizing the expression, purification, formulation, storage and structural studies of proteins. In this review, discussion will focus on factors affecting protein stability, on a somewhat practical level, particularly from the view of a protein crystallographer. The differences between protein conformational stability and protein compositional stability will be discussed, along with a brief introduction to key methods useful for analyzing protein stability. Finally, tactics for addressing protein-stability issues during protein expression, purification and crystallization will be discussed. PMID:26841758

  8. Aging assessment of essential HVAC chillers used in nuclear power plants

    SciTech Connect

    Blahnik, D.E.; Camp, T.W.

    1996-09-01

    The Pacific Northwest Laboratory conducted a comprehensive aging assessment of chillers used in the essential safety air-conditioning systems in nuclear power plants (NPPs). The chillers used, and air-conditioning systems served, vary in design from plant to plant. The review of operating experience indicated that chillers experience aging degradation and failures. The primary aging factors of concern for chillers include vibration, excessive temperatures and pressures, thermal cycling, chemical attack, and poor quality cooling water. The evaluation of Licensee Event Reports (LERs) indicated that about 38% of the failures were primarily related to aging, 55% were partially aging related, and 7% of the failures were unassignable. About 25% of the failures were primarily caused by human, design, procedure, and other errors. The large number of errors is probably directly related to the complexity of chillers and their interfacing systems. Nearly all of the LERs were the result of entering plant Technical Specification Limiting Condition for Operation (LCO) that initiated remedial actions like plant shutdown procedures. The trend for chiller-related LERs has stabilized at about 0.13 LERs per plant year since 1988. Carefully following the vendor procedures and monitoring the equipment can help to minimize and/or eliminate most of the premature failures. Recording equipment performance can be useful for trending analysis. Periodic operation for a few hours on a weekly or monthly basis is useful to remove moisture and non-condensable gases that gradually build up inside the chiller. Chiller pressurization kits are available that will help minimize the amount of moisture and air ingress to low-pressure chillers during standby periods. The assessment of service life condition monitoring of chillers indicated there are many simple to sophisticated methods available that can help in chiller surveillance and monitoring.

  9. Essentials of English Language Testing.

    ERIC Educational Resources Information Center

    Kitao, S. Kathleen; Kitao, Kenji

    This book covers essential problems and basic concepts of English language testing. There are 20 chapters in four sections. Section 1, "Background," includes: (1) "Why Teachers Test"; (2) "Some Definitions"; (3) "Validity and Reliability"; and (4) "What You Should Learn about Standardized Tests." Section 2, "Preparing To Write Tests," includes:

  10. Intellectual Workers and Essential Freedoms.

    ERIC Educational Resources Information Center

    Edley, Christopher Jr.

    2000-01-01

    Journalists and college professors deserve certain privileges, including freedom of speech and academic freedom, but they must adapt their work to increasingly diverse populations. They must confront public mistrust, convince people that these freedoms are worthwhile, and protect essential public rights through what they study and teach and to…

  11. Five Essentials of Emergency Planning

    ERIC Educational Resources Information Center

    Barnes, Jill M.

    2011-01-01

    Principals and other administrators seem to be perpetually overworked. There is always something that still needs to be done at the end of the day, and it is easy for disaster planning and preparedness to keep slipping to the bottom of the list. However, disaster preparation is essential, even when planning for the unknown. At some point in every…

  12. Essentials for the Teacher's Toolbox

    ERIC Educational Resources Information Center

    Uhler, Jennifer

    2012-01-01

    Every profession has a set of essential tools for carrying out its work. Airplane mechanics cannot repair engines without sophisticated diagnostics, wrenches, and pliers. Surgeons cannot operate without scalpels and clamps. In contrast, teaching has often been perceived as a profession requiring only students, chalk, and a blackboard in order for…

  13. Minimum Teaching Essentials: Grade 6.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This guide presents the "minimum teaching essentials" published by the New York City Board of Education for grade 6. Covered are the following subject areas: (1) art; (2) bilingual education; (3) career education; (4) health education; (5) library media; (6) mathematics; (7) music; (8) physical education; (9) science; and (10) social studies. Work

  14. A Rebuttal of Essential Sociolinguistics.

    ERIC Educational Resources Information Center

    Janicki, Karol

    The Aristotelian approach to definition, labeled essentialism, is examined, and its relationship to sociolinguistics is discussed. Aristotle taught that a definition points to the essence of something, perhaps by naming it, and then describes it. Popper criticized this approach to definition as overly verbose in that it invites an infinite

  15. [Equipment and technology in robotics].

    PubMed

    Murphy, Declan; Challacombe, Ben; Nedas, Tim; Elhage, Oussama; Althoefer, Kaspar; Seneviratne, Lakmal; Dasgupta, Prokar

    2007-05-01

    We review the evolution and current status of robotic equipment and technology in urology. We also describe future developments in the key areas of virtual reality simulation, mechatronics and nanorobotics. The history of robotic technology is reviewed and put into the context of current systems. Experts in the associated fields of nanorobotics, mechatronics and virtual reality simulation simulation review the important future developments in these areas. PMID:17626526

  16. LASE equipment mounting deck assembly

    NASA Technical Reports Server (NTRS)

    1991-01-01

    LASE installation graphic illustration; LASE equipment mounting deck assembly graphic illustration. The Lidar Atmospheric Sensing experimental (LASE) instrument, which lies on NASA's high-altitude ER-2 aircraft, has been developed AS A PRECURSOR TO FUTURE NASA Space-Based Global Lidar missions. LASE performed the first ever, fully autonomous, Differential Absorption Lidar (DIAL) vertical profile measurements of water vapor and Lidar measurements of aerosols and provided the highest altitude tropospheric data ever recorded.

  17. Firefighters Integrated Response Equipment System

    NASA Technical Reports Server (NTRS)

    Kaplan, H.; Abeles, F.

    1978-01-01

    The Firefighters Integrated Response Equipment System (Project FIRES) is a joint National Fire Prevention and Control Administration (NFPCA)/National Aeronautics and Space Administration (NASA) program for the development of an 'ultimate' firefighter's protective ensemble. The overall aim of Project FIRES is to improve firefighter protection against hazards, such as heat, flame, smoke, toxic fumes, moisture, impact penetration, and electricity and, at the same time, improve firefighter performance by increasing maneuverability, lowering weight, and improving human engineering design of his protective ensemble.

  18. Equipment life cycle costs minimised.

    PubMed

    Kuligowski, Sharon

    2004-11-01

    With the cost of energy now a major component of building operating costs, NHS Trust managers increasingly focus on estimating total life cycle costs of equipment such as boiler room and heat, steam and incineration plant. "Life cycle costing" is a broad term and encompasses a wide range of techniques that take into account both initial and future costs as well as the savings of an investment over a period of time. PMID:15575554

  19. Vibration budget for observatory equipment

    NASA Astrophysics Data System (ADS)

    MacMartin, Douglas G.; Thompson, Hugh

    2015-07-01

    Vibration from equipment mounted on the telescope and in summit support buildings has been a source of performance degradation at existing astronomical observatories, particularly for adaptive optics performance. Rather than relying only on best practices to minimize vibration, we present here a vibration budget that specifies allowable force levels from each source of vibration in the observatory (e.g., pumps, chillers, cryocoolers, etc.). This design tool helps ensure that the total optical performance degradation due to vibration is less than the corresponding error budget allocation and is also useful in design trade-offs, specifying isolation requirements for equipment, and tightening or widening individual equipment vibration specifications as necessary. The vibration budget relies on model-based analysis of the optical consequences that result from forces applied at different locations and frequencies, including both image jitter and primary mirror segment motion. We develop this tool here for the Thirty Meter Telescope but hope that this approach will be broadly useful to other observatories, not only in the design phase, but for verification and operations as well.

  20. Assessment of HYGAS mechanical equipment

    SciTech Connect

    Albrecht, P.R.; Kramberger, F.E.; Recupero, R.M.; Verden, M.L.; Rees, K.

    1980-10-01

    The HYGAS process, which converts coal to substitute natural gas, is being developed by the Institute of Gas Technology (IGT) using an 80 ton per day pilot plant located in Chicago, Illinois. Plant design started in 1967 and testing began in October 1971. Since then, 18,000 tons of both Eastern and Western coal have been gasified. Assessment of the mechanical equipment was made by Mechanical Technology Incorporated (MTI) in collaboration with a DOE on-site representative and a representative from IGT, the operating contractor. Data for the assessment were obtained by reviewing all available maintenance records, by interviewing key personnel from maintenance and operations, and by observing repairs and maintenance procedures where possible. While operating the plant, a variety of equipment problems were addressed, many of which are generic to HYGAS as well as other coal conversion processes. Some problems were solved completely while others were solved to suit the limited needs of the pilot plant. Accordingly, the emphasis of this study is on the degree of success in dealing with equipment failures, the unresolved problems and the implication to future coal conversion plants.

  1. Strategy Guideline: HVAC Equipment Sizing

    SciTech Connect

    Burdick, A.

    2012-02-01

    The heating, ventilation, and air conditioning (HVAC) system is arguably the most complex system installed in a house and is a substantial component of the total house energy use. A right-sized HVAC system will provide the desired occupant comfort and will run efficiently. This Strategy Guideline discusses the information needed to initially select the equipment for a properly designed HVAC system. Right-sizing of an HVAC system involves the selection of equipment and the design of the air distribution system to meet the accurate predicted heating and cooling loads of the house. Right-sizing the HVAC system begins with an accurate understanding of the heating and cooling loads on a space; however, a full HVAC design involves more than just the load estimate calculation - the load calculation is the first step of the iterative HVAC design procedure. This guide describes the equipment selection of a split system air conditioner and furnace for an example house in Chicago, IL as well as a heat pump system for an example house in Orlando, Florida. The required heating and cooling load information for the two example houses was developed in the Department of Energy Building America Strategy Guideline: Accurate Heating and Cooling Load Calculations.

  2. A simplified spatial model for BWR stability

    SciTech Connect

    Berman, Y.; Lederer, Y.; Meron, E.

    2012-07-01

    A spatial reduced order model for the study of BWR stability, based on the phenomenological model of March-Leuba et al., is presented. As one dimensional spatial dependence of the neutron flux, fuel temperature and void fraction is introduced, it is possible to describe both global and regional oscillations of the reactor power. Both linear stability analysis and numerical analysis were applied in order to describe the parameters which govern the model stability. The results were found qualitatively similar to past results. Doppler reactivity feedback was found essential for the explanation of the different regions of the flow-power stability map. (authors)

  3. Essential Medicines in a High Income Country: Essential to Whom?

    PubMed Central

    2015-01-01

    Objective To explore the perspectives of a diverse group of stakeholders engaged in medicines decision making around what constitutes an “essential” medicine, and how the Essential Medicines List (EML) concept functions in a high income country context. Methods In-depth qualitative semi-structured interviews were conducted with 32 Australian stakeholders, recognised as decision makers, leaders or advisors in the area of medicines reimbursement or supply chain management. Participants were recruited from government, pharmaceutical industry, pharmaceutical wholesale/distribution companies, medicines non-profit organisations, academic health disciplines, hospitals, and consumer groups. Perspectives on the definition and application of the EML concept in a high income country context were thematically analysed using grounded theory approach. Findings Stakeholders found it challenging to describe the EML concept in the Australian context because many perceived it was generally used in resource scarce settings. Stakeholders were unable to distinguish whether nationally reimbursed medicines were essential medicines in Australia. Despite frequent generic drug shortages and high prices paid by consumers, many struggled to describe how the EML concept applied to Australia. Instead, broad inclusion of consumer needs, such as rare and high cost medicines, and consumer involvement in the decision making process, has led to expansive lists of nationally subsidised medicines. Therefore, improved communication and coordination is needed around shared interests between stakeholders regarding how medicines are prioritised and guaranteed in the supply chain. Conclusions This study showed that decision-making in Australia around reimbursement of medicines has strayed from the fundamental utilitarian concept of essential medicines. Many stakeholders involved in medicine reimbursement decisions and management of the supply chain did not consider the EML concept in their approach. The wide range of views of what stakeholders considered were essential medicines, challenges whether the EML concept is out-dated or underutilised in high income countries. PMID:26650544

  4. Used energy-related laboratory equipment grant program for institutions of higher learning. Eligible equipment catalog

    SciTech Connect

    Not Available

    1994-07-01

    This is a listing of energy related equipment available through the Energy-Related Laboratory Equipment Grant Program which grants used equipment to institutions of higher education for energy-related research. Information included is an overview of the program, how to apply for a grant of equipment, eligibility requirements, types of equipment available, and the costs for the institution.

  5. JCE Online: Equipment Buyers Guide

    NASA Astrophysics Data System (ADS)

    Holmes, Jon L.

    1999-01-01

    The Equipment Buyers Guide was edited by Jo Rita Jordan. The new Equipment Buyers Guide, bound into the back of this issue, is also a new resource of JCE Internet. This resource provides an online source for the information contained in the printed guide. Placing this information online allows us to regularly update it and to provide live links to the suppliers' WWW sites. The organization of the online version parallels that of the print version. There is an alphabetical list of suppliers and a categorical listing. Links to these lists are provided on every page in the left-hand navigation bar. To quickly find information about a particular supplier, you click Supplier List, click the letter that begins the supplier's name, and scroll through the list to find the supplier. To find which suppliers provide a particular type of instrument or equipment, use the Categories link; click the category of the equipment you are looking for and then click the link to a supplier. You will then be taken to an alphabetical supplier listing page where you can scroll until you find the particular supplier of the item for which you are looking. Once you have found a supplier, the online Equipment Buyers Guide gives you the traditional contact information. But in addition, you also get one-click access to the WWW sites of the suppliers that have them. Depending on the site, you should be able to find information about the items that you seek and may even be able to order the items online! We think that you will find the online version of the Equipment Buyers Guide useful. To make it more useful, please send your suggestions, any errors or omissions you find, and any additional categories to the editor at jjordan@world.std.com The online Equipment Buyers Guide can be found at JCE Online at http://JChemEd.chem.wisc.edu/JCEWWW/Resources/EBG/ JCE Online in '99 JCE Online is your online source of "all things JCE". In order to provide you with an even more useful online resource, JCE Online is undergoing a facelift that will be unveiled at the start of the 1999. In addition to a modified look, we have upgraded the navigation system to provide you with additional links to get you to the information you are looking for more quickly. The new navigation system will retain a menu bar and the left-hand navigation bar. The menu bar across the top of the page will provide quick access to "global" reader service, author, and reviewer information. It will also provide links to a new site map that will give you an overall view of the organization of JCE Online and a new site-wide search engine. The left-hand navigation bar will contain context-sensitive links, sensitive to the specific areas of JCE Online: Journal, Software, Internet, Chem Ed Today. Generally, there will be several more links here than in the current version of JCE Online. We invite you to take a look at the facelift in progress and encourage you to provide suggestions and comments. Please share your suggestions with us, but keep in mind that this is a work in progress and not all links will be working and not all features will be implemented. Email your suggestions to jceonline@chem.wisc.edu. JCE Online 99 can be previewed at http://JChemEd.chem.wisc.edu/Online99/

  6. Turbulence stabilization

    NASA Astrophysics Data System (ADS)

    Mao, Yu; Gilles, Jrme

    2012-06-01

    We recently developed a new approach to get a stabilized image from a sequence of frames acquired through atmospheric turbulence. The goal of this algorihtm is to remove the geometric distortions due by the atmosphere movements. This method is based on a variational formulation and is efficiently solved by the use of Bregman iterations and the operator splitting method. In this paper we propose to study the influence of the choice of the regularizing term in the model. Then we proposed to experiment some of the most used regularization constraints available in the litterature.

  7. Large-scale preparation of clove essential oil and eugenol-loaded liposomes using a membrane contactor and a pilot plant.

    PubMed

    Sebaaly, Carine; Greige-Gerges, Hélène; Agusti, Géraldine; Fessi, Hatem; Charcosset, Catherine

    2016-06-01

    Based on our previous study where optimal conditions were defined to encapsulate clove essential oil (CEO) into liposomes at laboratory scale, we scaled-up the preparation of CEO and eugenol (Eug)-loaded liposomes using a membrane contactor (600 mL) and a pilot plant (3 L) based on the principle of ethanol injection method, both equipped with a Shirasu Porous Glass membrane for injection of the organic phase into the aqueous phase. Homogenous, stable, nanometric-sized and multilamellar liposomes with high phospholipid, Eug loading rates and encapsulation efficiency of CEO components were obtained. Saturation of phospholipids and drug concentration in the organic phase may control the liposome stability. Liposomes loaded with other hydrophobic volatile compounds could be prepared at large scale using the ethanol injection method and a membrane for injection. PMID:26099849

  8. System Design Description PFP Thermal Stabilization

    SciTech Connect

    RISENMAY, H.R.

    2002-08-23

    The purpose of this document is to provide a system design description (SDD) and design basis for the Plutonium Finishing Plant (PFP) Thermal Stabilization project. The chief objective of the SDD is to document the Structures, Systems, and Components (SSCs) that establish and maintain the facility Safety Envelope necessary for normal safe operation of the facility; as identified in the FSAR, the OSRs, and Safety Assessment Documents (SADs). This safety equipment documentation should satisfy guidelines for the SDD given in WHC-SD-CP-TI-181, Criteria for Identification and Control of Equipment Necessary for Preservation of the Safety Envelope and Safe Operation of PFP. The basis for operational, alarm response, maintenance, and surveillance procedures are also identified and justified in this document. This document and its appendices address the following elements of the PFP Thermal Stabilization project: Functional and design requirements; Design description; Safety Envelope Analysis; Safety Equipment Class; and Operational, maintenance and surveillance procedures.

  9. System Design Description PFP Thermal Stabilization

    SciTech Connect

    RISENMAY, H.R.

    2000-04-25

    The purpose of this document is to provide a system design description (SDD) and design basis for the Plutonium Finishing Plant (PFP) Thermal Stabilization project. The chief objective of the SDD is to document the Structures, Systems, and Components (SSCs) that establish and maintain the facility Safety Envelope necessary for normal safe operation of the facility; as identified in the FSAR, the OSRs, and Safety Assessment Documents (SADs). This safety equipment documentation should satisfy guidelines for the SDD given in WHC-SD-CP-TI-18 1, Criteria for Identification and Control of Equipment Necessary for Preservation of the Safety Envelope and Safe Operation of PFP. The basis for operational, alarm response, maintenance, and surveillance procedures are also identified and justified in this document. This document and its appendices address the following elements of the PFP Thermal Stabilization project: Functional and design requirements; Design description; Safety Envelope Analysis; Safety Equipment Class; and Operational, maintenance and surveillance procedures.

  10. OxygenAbundant and Essential

    NASA Astrophysics Data System (ADS)

    Quinsey, Carolyn S.

    2003-10-01

    Oxygen is colorless, odorless, tasteless, aggressive, necessary for human life, and provides protection from the sun; it is the most abundant element in Earth's crust and makes up approximately two-thirds of the human body by mass. This essential element was the focus of Oxygen, a public symposium held at the University of WisconsinMadison. The symposium included eight presentations on topics related to oxygen; those presentations are synopsized in this article.

  11. Neurological disorders in essential thrombocythemia

    PubMed Central

    Billot, Segolene; Kouroupi, Eirini G.; Le Guilloux, Johan; Cassinat, Bruno; Jardin, Caroline; Laperche, Thierry; Fenaux, Pierre; Carpentier, Antoine F.; Kiladjian, Jean-Jacques

    2011-01-01

    Patients with essential thrombocythemia often complain of various subjective neurological symptoms. This prospective study aims to assess their incidence and response to therapy. Among 37 consecutive patients with essential thrombocythemia, 11 presented with neurological symptoms. Among them 4 had thrombotic events, 7 complained of transient or fluctuating subjective symptoms, and one had both. Brain magnetic resonance imagery failed to detect any substratum in patients with subjective symptoms. JAK2V617F mutation was found in 9 of 11 patients with neurological symptoms versus 14 of 26 patients without symptoms. Ten patients received low-dose aspirin for these symptoms: complete resolution was observed in 3, improvement with persisting episodes in 2, and resistance to aspirin in 2 patients, in whom addition of cytoreductive therapy became necessary to resolve those disabling symptoms. In this prospective cohort, 30% of patients with essential thrombocythemia presented neurological symptoms. Aspirin was fully efficient in only 30% of cases. JAK2V617F mutation could be a risk factor for such symptoms. PMID:21933860

  12. General aviation avionics equipment maintenance

    NASA Technical Reports Server (NTRS)

    Parker, C. D.; Tommerdahl, J. B.

    1978-01-01

    Maintenance of general aviation avionics equipment was investigated with emphasis on single engine and light twin engine general aviation aircraft. Factors considered include the regulatory agencies, avionics manufacturers, avionics repair stations, the statistical character of the general aviation community, and owners and operators. The maintenance, environment, and performance, repair costs, and reliability of avionics were defined. It is concluded that a significant economic stratification is reflected in the maintenance problems encountered, that careful attention to installations and use practices can have a very positive impact on maintenance problems, and that new technologies and a general growth in general aviation will impact maintenance.

  13. Fire suppression and detection equipment

    SciTech Connect

    E.E. Bates

    2006-01-15

    Inspection and testing guidelines go beyond the 'Code of Federal Regulation'. Title 30 of the US Code of Federal Regulations (30 CFR) contains requirements and references to national standards for inspection, testing and maintenance of fire suppression and detection equipment for mine operators. However, federal requirements have not kept pace with national standards and best practices. The article lists National Fire Protection (NFPA) standards that are referenced by the US Mine Safety and Health Administration (MSHA) in 30 CFR. It then discusses other NFPA Standards excluded from 30 CFR and explains the NFPA standard development process. 2 refs., 3 tabs., 5 photos.

  14. Interface standards for computer equipment

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The ability to configure data systems using modules provided by independent manufacturers is complicated by the wide range of electrical, mechanical, and functional characteristics exhibited within the equipment provided by different manufacturers of computers, peripherals, and terminal devices. A number of international organizations were and still are involved in the creation of standards that enable devices to be interconnected with minimal difficulty, usually involving only a cable or data bus connection that is defined by the standard. The elements covered by an interface standard are covered and the most prominent interface standards presently in use are identified and described.

  15. Photographic Equipment Test System (PETS)

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The Photographic Equipment Test System is presented. The device is a mobile optical system designed for evaluating performance of various sensors in a laboratory, in a vacuum chamber or on a flight line. The carriage is designed to allow elevation as well as azimuth control of the direction of the light from the collimator. The pneumatic tires provide an effective vibration isolation system. A target/illumination system is mounted on a motor driven linear slide, and focusing and exposure control can be operated remotely from the small electronics control console.

  16. HAND TRUCK FOR HANDLING EQUIPMENT

    DOEpatents

    King, D.W.

    1959-02-24

    A truck is described for the handling of large and relatively heavy pieces of equipment and particularly for the handling of ion source units for use in calutrons. The truck includes a chassis and a frame pivoted to the chassis so as to be operable to swing in the manner of a boom. The frame has spaced members so arranged that the device to be handled can be suspended between or passed between these spaced members and also rotated with respect to the frame when the device is secured to the spaced members.

  17. 21 CFR 1250.34 - Refrigeration equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    .... Each refrigerator shall be equipped with a thermometer located in the warmest portion thereof. Waste water drains from ice boxes, refrigerating equipment, and refrigerated spaces shall be so installed...

  18. 21 CFR 1250.34 - Refrigeration equipment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    .... Each refrigerator shall be equipped with a thermometer located in the warmest portion thereof. Waste water drains from ice boxes, refrigerating equipment, and refrigerated spaces shall be so installed...

  19. 21 CFR 1250.34 - Refrigeration equipment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    .... Each refrigerator shall be equipped with a thermometer located in the warmest portion thereof. Waste water drains from ice boxes, refrigerating equipment, and refrigerated spaces shall be so installed...

  20. 14 CFR 23.1415 - Ditching equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Ditching equipment. (a) Emergency flotation and signaling equipment required by any operating rule in this... break before submerging the empty raft to which it is attached. (d) Each signaling device required...

  1. 14 CFR 23.1415 - Ditching equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Ditching equipment. (a) Emergency flotation and signaling equipment required by any operating rule in this... break before submerging the empty raft to which it is attached. (d) Each signaling device required...

  2. 14 CFR 23.1415 - Ditching equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Ditching equipment. (a) Emergency flotation and signaling equipment required by any operating rule in this... break before submerging the empty raft to which it is attached. (d) Each signaling device required...

  3. 14 CFR 23.1415 - Ditching equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Ditching equipment. (a) Emergency flotation and signaling equipment required by any operating rule in this... break before submerging the empty raft to which it is attached. (d) Each signaling device required...

  4. 14 CFR 23.1415 - Ditching equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Ditching equipment. (a) Emergency flotation and signaling equipment required by any operating rule in this... break before submerging the empty raft to which it is attached. (d) Each signaling device required...

  5. ["Public Health-2001" exhibition: medical equipment].

    PubMed

    Shvedov, Iu A

    2002-01-01

    The paper presents a review of medical equipment displayed at the 11th International Exhibition "Public Health, Medical Equipment, and Drugs" ("Public Health-2001"). The exhibition was held in Moscow on December 3-7, 2001. PMID:12224247

  6. 50 CFR 260.102 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... chemical action or physical contact. Such equipment shall be kept in good repair and sanitary condition... and effective bactericidal treatment. Insofar as is practicable, all such equipment shall be made of... with Good Manufacturing Practice Regulations, 21 CFR part 128....

  7. 21 CFR 1250.34 - Refrigeration equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... SANITATION Food Service Sanitation on Land and Air Conveyances, and Vessels § 1250.34 Refrigeration equipment... water drains from ice boxes, refrigerating equipment, and refrigerated spaces shall be so installed...

  8. 21 CFR 1250.34 - Refrigeration equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SANITATION Food Service Sanitation on Land and Air Conveyances, and Vessels § 1250.34 Refrigeration equipment... water drains from ice boxes, refrigerating equipment, and refrigerated spaces shall be so installed...

  9. STABILIZED OSCILLATOR

    DOEpatents

    Jessen, P.L.; Price, H.J.

    1958-03-18

    This patent relates to sine-wave generators and in particular describes a generator with a novel feedback circuit resulting in improved frequency stability. The generator comprises two triodes having a common cathode circuit connected to oscillate at a frequency and amplitude at which the loop galn of the circutt ls unity, and another pair of triodes having a common cathode circuit arranged as a conventional amplifier. A signal is conducted from the osciliator through a frequency selective network to the amplifier and fed back to the osciliator. The unique feature of the feedback circuit is the amplifier operates in the nonlinear portion of its tube characteristics thereby providing a relatively constant feedback voltage to the oscillator irrespective of the amplitude of its input signal.

  10. Stabilizing brokerage

    PubMed Central

    Stovel, Katherine; Golub, Benjamin; Milgrom, Eva M. Meyersson

    2011-01-01

    A variety of social and economic arrangements exist to facilitate the exchange of goods, services, and information over gaps in social structure. Each of these arrangements bears some relationship to the idea of brokerage, but this brokerage is rarely like the pure and formal economic intermediation seen in some modern markets. Indeed, for reasons illuminated by existing sociological and economic models, brokerage is a fragile relationship. In this paper, we review the causes of instability in brokerage and identify three social mechanisms that can stabilize fragile brokerage relationships: social isolation, broker capture, and organizational grafting. Each of these mechanisms rests on the emergence or existence of supporting institutions. We suggest that organizational grafting may be the most stable and effective resolution to the tensions inherent in brokerage, but it is also the most institutionally demanding. PMID:22198763

  11. Thermal design and flight validation for laser communicator equipment

    NASA Astrophysics Data System (ADS)

    Meng, Henghui; Geng, Liyin; Tan, Canghai; Li, Guoqiang

    2014-11-01

    Laser communicator equipment, designed for advanced optical communication, with a large capacity communication, good encryption and lightweight structures, etc., has a wide range of applications. As for the special transmission characteristic of optical communication, laser phase in the transmission path should be accurate, and less thermal deformation for the optical parts is required in the working process, so the laser communicator equipment has a high level requirement for temperature. Large power units cooling, outer two-dimensional rotating units, temperature control for rotating cable, and high temperature stability and equality, bring a challenge for thermal design. Using structure -electric-thermo-optical integration technology, active and passive thermal control methods are adopt in thermal design for laser communicator equipment: heat-conducted plate and heat pipe were adopted for heat transfer of high heat-flux parts, a new passive and active thermal control method to solve cable cryogenic problems, and high precision temperature control methods were applied for key parts. In-orbit data were analyzed, and the results prove the thermal design correct, and bring a way to thermal control for the equipment with high heat flux and running parts.

  12. Carbon Absorber Retrofit Equipment (CARE)

    SciTech Connect

    Klein, Eric

    2015-12-23

    During Project DE-FE0007528, CARE (Carbon Absorber Retrofit Equipment), Neumann Systems Group (NSG) designed, installed and tested a 0.5MW NeuStream® carbon dioxide (CO2) capture system using the patented NeuStream® absorber equipment and concentrated (6 molal) piperazine (PZ) as the solvent at Colorado Springs Utilities’ (CSU’s) Martin Drake pulverized coal (PC) power plant. The 36 month project included design, build and test phases. The 0.5MW NeuStream® CO2 capture system was successfully tested on flue gas from both coal and natural gas combustion sources and was shown to meet project objectives. Ninety percent CO2 removal was achieved with greater than 95% CO2product purity. The absorbers tested support a 90% reduction in absorber volume compared to packed towers and with an absorber parasitic power of less than 1% when configured for operation with a 550MW coal plant. The preliminary techno-economic analysis (TEA) performed by the Energy and Environmental Research Center (EERC) predicted an over-the-fence cost of $25.73/tonne of CO2 captured from a sub-critical PC plant.

  13. Brian Dunlap Examines Experimtal Equipment

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Youngstown, Ohio high school student, W. Brian Dunlap (center), discusses with Dr. Robert Head (right), and Henry Floyd, both of the Marshall Space Flight Center (MSFC), his experiment to be performed aboard the Skylab the following year. His experiment, 'Wave Motion Trough A Liquid in Zero Gravity' used a container attached to the end of a leaf spring which was oscillated at specific rates using two thickness differentiated types of liquids. Dunlap was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. The equipment for the experiments was manufactured at MSFC.

  14. Liquid-Liquid Extraction Equipment

    SciTech Connect

    Jack D. Law; Terry A. Todd

    2008-12-01

    Solvent extraction processing has demonstrated the ability to achieve high decontamination factors for uranium and plutonium while operating at high throughputs. Historical application of solvent extraction contacting equipment implies that for the HA cycle (primary separation of uranium and plutonium from fission products) the equipment of choice is pulse columns. This is likely due to relatively short residence times (as compared to mixer-settlers) and the ability of the columns to tolerate solids in the feed. Savannah River successfully operated the F-Canyon with centrifugal contactors in the HA cycle (which have shorter residence times than columns). All three contactors have been successfully deployed in uranium and plutonium purification cycles. Over the past 20 years, there has been significant development of centrifugal contactor designs and they have become very common for research and development applications. New reprocessing plants are being planned in Russia and China and the United States has done preliminary design studies on future reprocessing plants. The choice of contactors for all of these facilities is yet to be determined.

  15. Bar-Code System Tracks Test Equipment

    NASA Technical Reports Server (NTRS)

    Rogers, Jacob R.; Benton, Lesa M.; Perry, Roberta A.

    1990-01-01

    Administration of complicated system speeded and simplified. Computer system uses bar codes to keep track of more than 2,200 items of test equipment. BETUS (Barcode Equipment Tracking and Utilization System), maintains data base on what items borrowed, who is using them and where, and when calibrated. Keeps records on tools and small electronic components. Saves on equipment purchases and recovers missing equipment more quickly. Cuts check-in and checkout time by 90 percent.

  16. Preventive maintenance prioritization index of medical equipment using quality function deployment.

    PubMed

    Saleh, Neven; Sharawi, Amr A; Elwahed, Manal Abd; Petti, Alberto; Puppato, Daniele; Balestra, Gabriella

    2015-05-01

    Preventive maintenance is a core function of clinical engineering, and it is essential to guarantee the correct functioning of the equipment. The management and control of maintenance activities are equally important to perform maintenance. As the variety of medical equipment increases, accordingly the size of maintenance activities increases, the need for better management and control become essential. This paper aims to develop a new model for preventive maintenance priority of medical equipment using quality function deployment as a new concept in maintenance of medical equipment. We developed a three-domain framework model consisting of requirement, function, and concept. The requirement domain is the house of quality matrix. The second domain is the design matrix. Finally, the concept domain generates a prioritization index for preventive maintenance considering the weights of critical criteria. According to the final scores of those criteria, the prioritization action of medical equipment is carried out. Our model proposes five levels of priority for preventive maintenance. The model was tested on 200 pieces of medical equipment belonging to 17 different departments of two hospitals in Piedmont province, Italy. The dataset includes 70 different types of equipment. The results show a high correlation between risk-based criteria and the prioritization list. PMID:25029522

  17. 14 CFR 121.309 - Emergency equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... citations affecting § 121.309, see the List of CFR Sections Affected, which appears in the Finding Aids... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Emergency equipment. 121.309 Section 121... Emergency equipment. (a) General: No person may operate an airplane unless it is equipped with the...

  18. 14 CFR 121.309 - Emergency equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... citations affecting § 121.309, see the List of CFR Sections Affected, which appears in the Finding Aids... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Emergency equipment. 121.309 Section 121... Emergency equipment. (a) General: No person may operate an airplane unless it is equipped with the...

  19. 14 CFR 121.309 - Emergency equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... citations affecting § 121.309, see the List of CFR Sections Affected, which appears in the Finding Aids... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Emergency equipment. 121.309 Section 121... Emergency equipment. (a) General: No person may operate an airplane unless it is equipped with the...

  20. 14 CFR 121.309 - Emergency equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... citations affecting § 121.309, see the List of CFR Sections Affected, which appears in the Finding Aids... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Emergency equipment. 121.309 Section 121... Emergency equipment. (a) General: No person may operate an airplane unless it is equipped with the...

  1. Inexpensive Physical Education Equipment for Children.

    ERIC Educational Resources Information Center

    Werner, Peter H.; Simmons, Richard A.

    This book presents ideas for constructing and utilizing homemade recreational equipment for elementary school children. Each chapter deals with acquisition of materials, construction of equipment, and developmental objectives and activities for using the equipment with children. A chapter called "Save Your Junk" gives instructions on how to make

  2. 7 CFR 3019.34 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model number... be treated as program income. (e) When acquiring replacement equipment, the recipient may use the... replacement equipment subject to the approval of the Federal awarding agency. (f) The recipient's...

  3. 7 CFR 3019.34 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... following information. (i) A description of the equipment. (ii) Manufacturer's serial number, model number... be treated as program income. (e) When acquiring replacement equipment, the recipient may use the... replacement equipment subject to the approval of the Federal awarding agency. (f) The recipient's...

  4. 21 CFR 866.4540 - Immunonephelometer equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Immunonephelometer equipment. 866.4540 Section 866.4540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunology Laboratory Equipment and Reagents § 866.4540 Immunonephelometer equipment....

  5. 21 CFR 866.4520 - Immunofluorometer equipment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Immunofluorometer equipment. 866.4520 Section 866.4520 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunology Laboratory Equipment and Reagents § 866.4520 Immunofluorometer equipment....

  6. 33 CFR 175.135 - Existing equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.135 Existing equipment....

  7. Your Equipment Dollar, [Revised.] Money Management.

    ERIC Educational Resources Information Center

    Baran, Nancy H., Ed.; Tarrant, Sharon M., Ed.

    This booklet on household equipment, 1 in a series of 12, covers all the basic aspects of personal- and family-money management. Suitable for use by high school and college students as well as adults, this handbook offers information to help buyers purchase household equipment that is within their budget. Section 1 discusses managing equipment

  8. 43 CFR 12.934 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., verify the existence, current utilization, and continued need for the equipment. (4) A control system... Lands: Interior Office of the Secretary of the Interior ADMINISTRATIVE AND AUDIT REQUIREMENTS AND COST... sell the equipment and use the proceeds to offset the costs of the replacement equipment subject to...

  9. 43 CFR 12.934 - Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., verify the existence, current utilization, and continued need for the equipment. (4) A control system... Lands: Interior Office of the Secretary of the Interior ADMINISTRATIVE AND AUDIT REQUIREMENTS AND COST... sell the equipment and use the proceeds to offset the costs of the replacement equipment subject to...

  10. 43 CFR 12.934 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., verify the existence, current utilization, and continued need for the equipment. (4) A control system... Lands: Interior Office of the Secretary of the Interior ADMINISTRATIVE AND AUDIT REQUIREMENTS AND COST... sell the equipment and use the proceeds to offset the costs of the replacement equipment subject to...

  11. 43 CFR 12.934 - Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., verify the existence, current utilization, and continued need for the equipment. (4) A control system... Lands: Interior Office of the Secretary of the Interior ADMINISTRATIVE AND AUDIT REQUIREMENTS AND COST... sell the equipment and use the proceeds to offset the costs of the replacement equipment subject to...

  12. 43 CFR 12.934 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., verify the existence, current utilization, and continued need for the equipment. (4) A control system... Lands: Interior Office of the Secretary of the Interior ADMINISTRATIVE AND AUDIT REQUIREMENTS AND COST... sell the equipment and use the proceeds to offset the costs of the replacement equipment subject to...

  13. 7 CFR 58.319 - Printing equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Printing equipment. 58.319 Section 58.319 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards....319 Printing equipment. All printing equipment shall be designed so as to adequately protect...

  14. 30 CFR 250.502 - Equipment movement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.502 Equipment movement. The movement of well-completion rigs and related equipment on and off a platform or from well to well... well-completion rigs and related equipment, unless otherwise approved by the District Manager. A...

  15. 30 CFR 250.502 - Equipment movement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.502 Equipment movement. The movement of well-completion rigs and related equipment on and off a... master valve prior to moving well-completion rigs and related equipment, unless otherwise approved by...

  16. 30 CFR 250.502 - Equipment movement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.502 Equipment movement. The movement of well-completion rigs and related equipment on and off a... master valve prior to moving well-completion rigs and related equipment, unless otherwise approved by...

  17. 30 CFR 250.502 - Equipment movement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.502 Equipment movement. The movement of well-completion rigs and related equipment on and off a... master valve prior to moving well-completion rigs and related equipment, unless otherwise approved by...

  18. 40 CFR 65.103 - Equipment identification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 16 2012-07-01 2012-07-01 false Equipment identification. 65.103 Section 65.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Equipment Leaks 65.103 Equipment identification. (a)...

  19. 40 CFR 65.103 - Equipment identification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 16 2013-07-01 2013-07-01 false Equipment identification. 65.103 Section 65.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Equipment Leaks 65.103 Equipment identification. (a)...

  20. 40 CFR 65.103 - Equipment identification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 16 2014-07-01 2014-07-01 false Equipment identification. 65.103 Section 65.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Equipment Leaks 65.103 Equipment identification. (a)...

  1. Equipment available for automating rig operations

    SciTech Connect

    McNair, W.L. )

    1990-04-16

    Several manufacturers are producing automated rig equipment, from complete systems to individual functions for existing drilling rigs. Significant improvements in well site time, costs of operations, and improved drilling performance have led drilling contractors to install this equipment on their rigs. This paper details some of the equipment available for automating rigs.

  2. Energy data for manure handling equipment

    SciTech Connect

    Safley, L.M.; Nye, J.C.

    1982-07-01

    Approximately 11.4 percent of the energy required to produce livestock is devoted to handling manure. This article presents information on the operating characteristics of most types of manure handling equipment. Equations are developed which describe the power requirements for many of the pieces of equipment discussed. Estimates of energy requirements for given conditions for several pieces of manure handling equipment are presented.

  3. 47 CFR 78.23 - Equipment tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Equipment tests. 78.23 Section 78.23... SERVICE Applications and Licenses § 78.23 Equipment tests. (a) Following the grant of a CARS license, the... Commission, conduct equipment tests for the purpose of such adjustments and measurements as may be...

  4. 47 CFR 73.1610 - Equipment tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Equipment tests. 73.1610 Section 73.1610... Rules Applicable to All Broadcast Stations § 73.1610 Equipment tests. (a) During the process of..., without further authority from the FCC, conduct equipment tests for the purpose of making such...

  5. 47 CFR 74.13 - Equipment tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Equipment tests. 74.13 Section 74.13... Services in Part 74 § 74.13 Equipment tests. (a) During the process of construction of any class of radio... equipment tests for the purpose of such adjustments and measurements as may be necessary to...

  6. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  7. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  8. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  9. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  10. 14 CFR 121.605 - Airplane equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Airplane equipment. 121.605 Section 121.605..., FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules 121.605 Airplane equipment. No person may dispatch or release an airplane unless it is airworthy and is equipped as prescribed in ...

  11. 14 CFR 121.605 - Airplane equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Airplane equipment. 121.605 Section 121.605..., FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules 121.605 Airplane equipment. No person may dispatch or release an airplane unless it is airworthy and is equipped as prescribed in ...

  12. 14 CFR 121.605 - Airplane equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Airplane equipment. 121.605 Section 121.605..., FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules 121.605 Airplane equipment. No person may dispatch or release an airplane unless it is airworthy and is equipped as prescribed in ...

  13. 14 CFR 121.605 - Airplane equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Airplane equipment. 121.605 Section 121.605..., FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules 121.605 Airplane equipment. No person may dispatch or release an airplane unless it is airworthy and is equipped as prescribed in ...

  14. 46 CFR 121.210 - Heating equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Heating equipment. 121.210 Section 121.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... SYSTEMS AND EQUIPMENT Cooking and Heating 121.210 Heating equipment. (a) Each heater must be...

  15. 46 CFR 121.210 - Heating equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Heating equipment. 121.210 Section 121.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... SYSTEMS AND EQUIPMENT Cooking and Heating 121.210 Heating equipment. (a) Each heater must be...

  16. 29 CFR 1926.1434 - Equipment modifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) and (ii) of this section are met. (5) Multiple manufacturers of equipment designed for use on marine work sites. The equipment is designed for marine work sites, contains major structural components from... 29 Labor 8 2012-07-01 2012-07-01 false Equipment modifications. 1926.1434 Section 1926.1434...

  17. 29 CFR 1926.1434 - Equipment modifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) and (ii) of this section are met. (5) Multiple manufacturers of equipment designed for use on marine work sites. The equipment is designed for marine work sites, contains major structural components from... 29 Labor 8 2014-07-01 2014-07-01 false Equipment modifications. 1926.1434 Section 1926.1434...

  18. 46 CFR 169.839 - Firefighting equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Firefighting equipment. 169.839 Section 169.839 Shipping... Operations Tests, Drills, and Inspections 169.839 Firefighting equipment. (a) The master or person in charge shall ensure that the vessel's firefighting equipment is at all times ready for use and that...

  19. 29 CFR 1926.1434 - Equipment modifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) and (ii) of this section are met. (5) Multiple manufacturers of equipment designed for use on marine work sites. The equipment is designed for marine work sites, contains major structural components from... 29 Labor 8 2013-07-01 2013-07-01 false Equipment modifications. 1926.1434 Section 1926.1434...

  20. 46 CFR 131.590 - Firefighting equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Firefighting equipment. 131.590 Section 131.590 Shipping..., Drills, and Inspections 131.590 Firefighting equipment. (a) The master shall ensure that the vessel's required firefighting equipment is on board in the prescribed location and always ready for use, other...

  1. 46 CFR 169.839 - Firefighting equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Firefighting equipment. 169.839 Section 169.839 Shipping... Operations Tests, Drills, and Inspections 169.839 Firefighting equipment. (a) The master or person in charge shall ensure that the vessel's firefighting equipment is at all times ready for use and that...

  2. 46 CFR 169.705 - Mooring equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Mooring equipment. 169.705 Section 169.705 Shipping... Control, Miscellaneous Systems, and Equipment 169.705 Mooring equipment. Each vessel must be fitted with ground tackle and hawsers deemed necessary by the Officer in Charge, Marine Inspection, depending...

  3. 46 CFR 169.705 - Mooring equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Mooring equipment. 169.705 Section 169.705 Shipping... Control, Miscellaneous Systems, and Equipment 169.705 Mooring equipment. Each vessel must be fitted with ground tackle and hawsers deemed necessary by the Officer in Charge, Marine Inspection, depending...

  4. 46 CFR 169.705 - Mooring equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Mooring equipment. 169.705 Section 169.705 Shipping... Control, Miscellaneous Systems, and Equipment 169.705 Mooring equipment. Each vessel must be fitted with ground tackle and hawsers deemed necessary by the Officer in Charge, Marine Inspection, depending...

  5. 46 CFR 169.705 - Mooring equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Mooring equipment. 169.705 Section 169.705 Shipping... Control, Miscellaneous Systems, and Equipment 169.705 Mooring equipment. Each vessel must be fitted with ground tackle and hawsers deemed necessary by the Officer in Charge, Marine Inspection, depending...

  6. 46 CFR 169.705 - Mooring equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Mooring equipment. 169.705 Section 169.705 Shipping... Control, Miscellaneous Systems, and Equipment 169.705 Mooring equipment. Each vessel must be fitted with ground tackle and hawsers deemed necessary by the Officer in Charge, Marine Inspection, depending...

  7. 46 CFR 169.839 - Firefighting equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Firefighting equipment. 169.839 Section 169.839 Shipping... Operations Tests, Drills, and Inspections 169.839 Firefighting equipment. (a) The master or person in charge shall ensure that the vessel's firefighting equipment is at all times ready for use and that...

  8. 46 CFR 169.839 - Firefighting equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Firefighting equipment. 169.839 Section 169.839 Shipping... Operations Tests, Drills, and Inspections 169.839 Firefighting equipment. (a) The master or person in charge shall ensure that the vessel's firefighting equipment is at all times ready for use and that...

  9. 46 CFR 131.590 - Firefighting equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Firefighting equipment. 131.590 Section 131.590 Shipping..., Drills, and Inspections 131.590 Firefighting equipment. (a) The master shall ensure that the vessel's required firefighting equipment is on board in the prescribed location and always ready for use, other...

  10. 29 CFR 1926.1434 - Equipment modifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) and (ii) of this section are met. (5) Multiple manufacturers of equipment designed for use on marine work sites. The equipment is designed for marine work sites, contains major structural components from... 29 Labor 8 2011-07-01 2011-07-01 false Equipment modifications. 1926.1434 Section 1926.1434...

  11. 46 CFR 131.590 - Firefighting equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Firefighting equipment. 131.590 Section 131.590 Shipping..., Drills, and Inspections 131.590 Firefighting equipment. (a) The master shall ensure that the vessel's required firefighting equipment is on board in the prescribed location and always ready for use, other...

  12. 46 CFR 131.590 - Firefighting equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Firefighting equipment. 131.590 Section 131.590 Shipping..., Drills, and Inspections 131.590 Firefighting equipment. (a) The master shall ensure that the vessel's required firefighting equipment is on board in the prescribed location and always ready for use, other...

  13. 46 CFR 131.590 - Firefighting equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Firefighting equipment. 131.590 Section 131.590 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Tests, Drills, and Inspections 131.590 Firefighting equipment. (a) The master shall ensure that the vessel's required firefighting equipment is on board...

  14. 46 CFR 169.839 - Firefighting equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Firefighting equipment. 169.839 Section 169.839 Shipping... Operations Tests, Drills, and Inspections 169.839 Firefighting equipment. (a) The master or person in charge shall ensure that the vessel's firefighting equipment is at all times ready for use and that...

  15. Inexpensive Physical Education Equipment for Children.

    ERIC Educational Resources Information Center

    Werner, Peter H.; Simmons, Richard A.

    This book presents ideas for constructing and utilizing homemade recreational equipment for elementary school children. Each chapter deals with acquisition of materials, construction of equipment, and developmental objectives and activities for using the equipment with children. A chapter called "Save Your Junk" gives instructions on how to make…

  16. 14 CFR 23.1431 - Electronic equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Electronic equipment. 23.1431 Section 23... Equipment § 23.1431 Electronic equipment. Link to an amendment published at 76 FR 75761, December 2, 2011. (a) In showing compliance with § 23.1309(b)(1) and (2) with respect to radio and electronic...

  17. 14 CFR 29.1431 - Electronic equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Electronic equipment. 29.1431 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Miscellaneous Equipment § 29.1431 Electronic... operation of any other radio or electronic unit, or system of units, required by this chapter....

  18. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  19. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  20. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  1. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  2. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  3. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  4. 46 CFR 121.220 - Cooking equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Cooking equipment. 121.220 Section 121.220 Shipping... SYSTEMS AND EQUIPMENT Cooking and Heating 121.220 Cooking equipment. (a) Doors on a cooking appliance... cooking appliance must be installed to prevent movement in heavy seas. (c) For a grill or similar type...

  5. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  6. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  7. 46 CFR 184.220 - Cooking equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Cooking equipment. 184.220 Section 184.220 Shipping...) VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating 184.220 Cooking equipment. (a) Doors on a cooking appliance must be provided with hinges and locking devices to...

  8. 46 CFR 28.405 - Hydraulic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Hydraulic equipment. 28.405 Section 28.405 Shipping... Operate With More Than 16 Individuals on Board § 28.405 Hydraulic equipment. (a) Each hydraulic system... than four times the system maximum operating pressure. (c) Each hydraulic system must be equipped...

  9. 46 CFR 28.880 - Hydraulic equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Hydraulic equipment. 28.880 Section 28.880 Shipping... INDUSTRY VESSELS Aleutian Trade Act Vessels § 28.880 Hydraulic equipment. (a) Each hydraulic system must be... times the system's maximum operating pressure. (c) Each hydraulic system must be equipped with at...

  10. Audiovisual Equipment Self Instruction Manual. Third Edition.

    ERIC Educational Resources Information Center

    Oates, Stanton C.

    An audiovisual equipment manual provides both the means of learning how to operate equipment and information needed to adjust equipment that is not performing properly. The manual covers the basic principles of operation for filmstrip-slide projectors, motion picture projectors, opaque projectors, overhead projectors, portable screens, record

  11. 30 CFR 77.1914 - Electrical equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Electrical equipment. 77.1914 Section 77.1914... Shaft Sinking § 77.1914 Electrical equipment. (a) Electric equipment employed below the collar of a.... (b) The insulation of all electric conductors employed below the collar of any slope or shaft...

  12. 33 CFR 175.135 - Existing equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Existing equipment. 175.135 Section 175.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) BOATING SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals 175.135 Existing equipment....

  13. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Safety equipment. 27.1561 Section 27.1561... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such as controls for automatic liferaft releases, must be plainly marked as to its method of operation. (b)...

  14. 17 CFR 256.307 - Equipment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Equipment. 256.307 Section 256... COMPANY ACT OF 1935 Service Company Property Accounts § 256.307 Equipment. This account shall include the cost of equipment owned by the service company and used in rendering services such as...

  15. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Safety equipment. 29.1561 Section 29.1561....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such as controls for automatic liferaft releases, must be plainly marked as to its method of operation....

  16. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Safety equipment. 29.1561 Section 29.1561....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such as controls for automatic liferaft releases, must be plainly marked as to its method of operation....

  17. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Safety equipment. 25.1561 Section 25.1561....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such as controls for automatic liferaft releases, must be plainly marked as to its method of operation....

  18. 17 CFR 256.307 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Equipment. 256.307 Section 256... COMPANY ACT OF 1935 Service Company Property Accounts § 256.307 Equipment. This account shall include the cost of equipment owned by the service company and used in rendering services such as...

  19. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Safety equipment. 27.1561 Section 27.1561... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such as controls for automatic liferaft releases, must be plainly marked as to its method of operation. (b)...

  20. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Safety equipment. 25.1561 Section 25.1561....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such as controls for automatic liferaft releases, must be plainly marked as to its method of operation....

  1. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Safety equipment. 29.1561 Section 29.1561....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such as controls for automatic liferaft releases, must be plainly marked as to its method of operation....

  2. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Safety equipment. 25.1561 Section 25.1561....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such as controls for automatic liferaft releases, must be plainly marked as to its method of operation....

  3. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Safety equipment. 27.1561 Section 27.1561... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such as controls for automatic liferaft releases, must be plainly marked as to its method of operation. (b)...

  4. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Safety equipment. 27.1561 Section 27.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such...

  5. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety equipment. 25.1561 Section 25.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  6. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety equipment. 29.1561 Section 29.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  7. 14 CFR 25.1561 - Safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Safety equipment. 25.1561 Section 25.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  8. 14 CFR 29.1561 - Safety equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Safety equipment. 29.1561 Section 29.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS....1561 Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency,...

  9. 14 CFR 27.1561 - Safety equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety equipment. 27.1561 Section 27.1561 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Safety equipment. (a) Each safety equipment control to be operated by the crew in emergency, such...

  10. 46 CFR 121.210 - Heating equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Heating equipment. 121.210 Section 121.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... SYSTEMS AND EQUIPMENT Cooking and Heating 121.210 Heating equipment. (a) Each heater must be...

  11. 46 CFR 121.210 - Heating equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Heating equipment. 121.210 Section 121.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... SYSTEMS AND EQUIPMENT Cooking and Heating 121.210 Heating equipment. (a) Each heater must be...

  12. 46 CFR 121.210 - Heating equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Heating equipment. 121.210 Section 121.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... SYSTEMS AND EQUIPMENT Cooking and Heating 121.210 Heating equipment. (a) Each heater must be...

  13. 14 CFR 121.335 - Equipment standards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements 121.335 Equipment standards. (a) Reciprocating engine powered airplanes. The oxygen apparatus, the minimum rates of... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Equipment standards. 121.335 Section...

  14. 14 CFR 121.335 - Equipment standards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements 121.335 Equipment standards. (a) Reciprocating engine powered airplanes. The oxygen apparatus, the minimum rates of... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Equipment standards. 121.335 Section...

  15. Proceedings: Substation Equipment Diagnostics Conference VIII

    SciTech Connect

    2000-06-01

    Advanced monitoring and diagnostic sensors and systems are needed to provide reliable and accurate information for determining the condition of major transmission substation equipment. The eighth EPRI Substation Equipment Diagnostics Conference highlighted the work of researchers, universities, manufacturers, and utilities in producing advanced monitoring and diagnostic equipment for substations.

  16. Proceedings: Tenth EPRI Substation Equipment Diagnostics Conference

    SciTech Connect

    2002-06-01

    Advanced monitoring and diagnostic sensors and systems are needed to provide reliable and accurate information for determining the condition of major transmission substation equipment. The tenth EPRI Substation Equipment Diagnostics Conference highlighted the work of researchers, universities, manufacturers, and utilities in producing advanced monitoring and diagnostic equipment for substations.

  17. Proceedings: Substation Equipment Diagnostics Conference IX

    SciTech Connect

    2001-09-01

    Advanced monitoring and diagnostic sensors and systems are needed to provide reliable and accurate information for determining the condition of major transmission substation equipment. The ninth EPRI Substation Equipment Diagnostics Conference highlighted the work of researchers, universities, manufacturers, and utilities in producing advanced monitoring and diagnostic equipment for substations.

  18. 14 CFR 121.605 - Airplane equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airplane equipment. 121.605 Section 121.605..., FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules 121.605 Airplane equipment. No person may dispatch or release an airplane unless it is airworthy and is equipped as prescribed in ...

  19. 38 CFR 49.34 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... disposal and sales price or the method used to determine current fair market value where a recipient... accordance with the following standards. For equipment with a current per unit fair market value of $5000 or... fair market value of the equipment. If the recipient has no need for the equipment, the recipient...

  20. 15 CFR 14.34 - Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the method used to determine current fair market value where a recipient compensates the DoC for its.... Equipment with a current per-unit fair market value of less than $5000 may be retained, sold, or otherwise... the current fair market value of the equipment. If the recipient has no need for the equipment,...