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Sample records for standardized stimuli boss

  1. Bank of Standardized Stimuli (BOSS) Phase II: 930 New Normative Photos

    PubMed Central

    Brodeur, Mathieu B.; Guérard, Katherine; Bouras, Maria

    2014-01-01

    Researchers have only recently started to take advantage of the developments in technology and communication for sharing data and documents. However, the exchange of experimental material has not taken advantage of this progress yet. In order to facilitate access to experimental material, the Bank of Standardized Stimuli (BOSS) project was created as a free standardized set of visual stimuli accessible to all researchers, through a normative database. The BOSS is currently the largest existing photo bank providing norms for more than 15 dimensions (e.g. familiarity, visual complexity, manipulability, etc.), making the BOSS an extremely useful research tool and a mean to homogenize scientific data worldwide. The first phase of the BOSS was completed in 2010, and contained 538 normative photos. The second phase of the BOSS project presented in this article, builds on the previous phase by adding 930 new normative photo stimuli. New categories of concepts were introduced, including animals, building infrastructures, body parts, and vehicles and the number of photos in other categories was increased. All new photos of the BOSS were normalized relative to their name, familiarity, visual complexity, object agreement, viewpoint agreement, and manipulability. The availability of these norms is a precious asset that should be considered for characterizing the stimuli as a function of the requirements of research and for controlling for potential confounding effects. PMID:25211489

  2. The Bank of Standardized Stimuli (BOSS), a New Set of 480 Normative Photos of Objects to Be Used as Visual Stimuli in Cognitive Research

    PubMed Central

    Brodeur, Mathieu B.; Dionne-Dostie, Emmanuelle; Montreuil, Tina; Lepage, Martin

    2010-01-01

    There are currently stimuli with published norms available to study several psychological aspects of language and visual cognitions. Norms represent valuable information that can be used as experimental variables or systematically controlled to limit their potential influence on another experimental manipulation. The present work proposes 480 photo stimuli that have been normalized for name, category, familiarity, visual complexity, object agreement, viewpoint agreement, and manipulability. Stimuli are also available in grayscale, blurred, scrambled, and line-drawn version. This set of objects, the Bank Of Standardized Stimuli (BOSS), was created specifically to meet the needs of scientists in cognition, vision and psycholinguistics who work with photo stimuli. PMID:20532245

  3. Outsourcing the Technology Boss.

    ERIC Educational Resources Information Center

    Olsen, Florence

    2003-01-01

    Describes how California's Peralta Community Colleges District decided to hire an outside company to manage its computer networks, but that problems cause it to now want a technology boss on its own staff. (EV)

  4. The Effects of DC Electromagnetic Stimuli in Conjunction with Standard Cryogenic Treatment of Metals

    NASA Astrophysics Data System (ADS)

    Leadlove, Kyle Leadlove; Evans, Austin; Seyfert, James; Watson, Casey R.; Paulin, Peter

    2016-03-01

    We explore modifications to the basic cryogenic procedures utilized by 300 Below Inc. to strengthen metal components. We consider the effects of adding DC electromagnetic stimuli in our efforts to further optimize the cryogenic treatment - i.e., to augment the already improved tensile strength, shear strength, thermal and electrical conductivity, etc. resulting from 300 Below Inc.'s traditional cryogenic process. We report on the wear-test performance of DC magneto-cryogenic treated samples relative to standard cryogenically treated samples and control samples.

  5. The Effects of AC Electromagnetic Stimuli in Conjunction with Standard Cryogenic Treatment of Metals

    NASA Astrophysics Data System (ADS)

    Seyfert, James; Evans, Austin; Leadlove, Kyle; Watson, Casey; Paulin, Peter; Peter Paulin Collaboration

    2016-03-01

    We explore modifications to the basic cryogenic procedures utilized by 300 Below Inc. to strengthen metal components. We consider the effects of adding AC electromagnetic stimuli in our efforts to further optimize the cryogenic treatment - i.e., to augment the already improved tensile strength, shear strength, thermal and electrical conductivity, etc. resulting from 300 Below Inc.'s traditional cryogenic process. We report on the wear-test performance of AC magneto-cryogenic treated samples relative to standard cryogenically treated samples and control samples. Replace this text with your abstract body.

  6. The BigBOSS Experiment

    SciTech Connect

    Schelgel, D.; Abdalla, F.; Abraham, T.; Ahn, C.; Allende Prieto, C.; Annis, J.; Aubourg, E.; Azzaro, M.; Bailey, S.; Baltay, C.; Baugh, C.; /APC, Paris /Brookhaven /IRFU, Saclay /Marseille, CPPM /Marseille, CPT /Durham U. / /IEU, Seoul /Fermilab /IAA, Granada /IAC, La Laguna

    2011-01-01

    BigBOSS will obtain observational constraints that will bear on three of the four 'science frontier' questions identified by the Astro2010 Cosmology and Fundamental Phyics Panel of the Decadal Survey: Why is the universe accelerating; what is dark matter and what are the properties of neutrinos? Indeed, the BigBOSS project was recommended for substantial immediate R and D support the PASAG report. The second highest ground-based priority from the Astro2010 Decadal Survey was the creation of a funding line within the NSF to support a 'Mid-Scale Innovations' program, and it used BigBOSS as a 'compelling' example for support. This choice was the result of the Decadal Survey's Program Priorization panels reviewing 29 mid-scale projects and recommending BigBOSS 'very highly'.

  7. Age-related decline in differentiated neural responses to rare target versus frequent standard stimuli.

    PubMed

    Mott, Katherine K; Alperin, Brittany R; Holcomb, Phillip J; Daffner, Kirk R

    2014-10-31

    One mechanism hypothesized to contribute to cognitive aging is the failure to recruit specialized neural modules and generate differentiated neural responses to various classes of stimuli. Here, ERPs were used to examine the extent to which target and standard stimulus types were processed differently by well-matched adults ages 19-99. Subjects responded to designated visual target letters under low and high load conditions. Temporospatial PCA was used to parse the P3b component, an index of categorization/memory updating. The P3b amplitude difference between targets and standards decreased substantially as a function of age. Dedifferentiation began in middle age, and continued into old-old age. The reduced differentiation of neural responses was driven by an age-related decline in the size of the P3b to targets and an age-related increase in the P3b to standards. Larger P3b amplitude to standards among older subjects was associated with higher executive capacity and better task performance. In summary, dedifferentiation begins relatively early in adulthood and progresses in a linear fashion throughout the lifespan. The age-related augmentation of the P3b to standards appears to reflect a compensatory mechanism that helps maintain task performance. PMID:25171804

  8. Age-related decline in differentiated neural responses to rare target versus frequent standard stimuli

    PubMed Central

    Mott, Katherine K.; Alperin, Brittany R.; Holcomb, Phillip J.; Daffner, Kirk R.

    2014-01-01

    One mechanism hypothesized to contribute to cognitive aging is the failure to recruit specialized neural modules and generate differentiated neural responses to various classes of stimuli. Here, ERPs were used to examine the extent to which target and standard stimulus types were processed differently by well-matched adults ages 19–99. Subjects responded to designated visual target letters under low and high load conditions. Temporospatial PCA was used to parse the P3b component, an index of categorization/memory updating. The P3b amplitude difference between targets and standards decreased substantially as a function of age. Dedifferentiation began in middle age, and continued into old-old age. The reduced differentiation of neural responses was driven by an age-related decline in the size of the P3b to targets and an age-related increase in the P3b to standards. Larger P3b amplitude to standards among older subjects was associated with higher executive capacity and better task performance. In summary, dedifferentiation begins relatively early in adulthood and progresses in a linear fashion throughout the lifespan. The age-related augmentation of the P3b to standards appears to reflect a compensatory mechanism that helps maintain task performance. PMID:25171804

  9. The BigBoss Experiment

    SciTech Connect

    Schelgel, D.; Abdalla, F.; Abraham, T.; Ahn, C.; Allende Prieto, C.; Annis, J.; Aubourg, E.; Azzaro, M.; Bailey, S.; Baltay, C.; Baugh, C.; Bebek, C.; Becerril, S.; Blanton, M.; Bolton, A.; Bromley, B.; Cahn, R.; Carton, P.-H.; Cervanted-Cota, J.L.; Chu, Y.; Cortes, M.; /APC, Paris /Brookhaven /IRFU, Saclay /Marseille, CPPM /Marseille, CPT /Durham U. / /IEU, Seoul /Fermilab /IAA, Granada /IAC, La Laguna / /IAC, Mexico / / /Madrid, IFT /Marseille, Lab. Astrophys. / / /New York U. /Valencia U.

    2012-06-07

    BigBOSS is a Stage IV ground-based dark energy experiment to study baryon acoustic oscillations (BAO) and the growth of structure with a wide-area galaxy and quasar redshift survey over 14,000 square degrees. It has been conditionally accepted by NOAO in response to a call for major new instrumentation and a high-impact science program for the 4-m Mayall telescope at Kitt Peak. The BigBOSS instrument is a robotically-actuated, fiber-fed spectrograph capable of taking 5000 simultaneous spectra over a wavelength range from 340 nm to 1060 nm, with a resolution R = {lambda}/{Delta}{lambda} = 3000-4800. Using data from imaging surveys that are already underway, spectroscopic targets are selected that trace the underlying dark matter distribution. In particular, targets include luminous red galaxies (LRGs) up to z = 1.0, extending the BOSS LRG survey in both redshift and survey area. To probe the universe out to even higher redshift, BigBOSS will target bright [OII] emission line galaxies (ELGs) up to z = 1.7. In total, 20 million galaxy redshifts are obtained to measure the BAO feature, trace the matter power spectrum at smaller scales, and detect redshift space distortions. BigBOSS will provide additional constraints on early dark energy and on the curvature of the universe by measuring the Ly-alpha forest in the spectra of over 600,000 2.2 < z < 3.5 quasars. BigBOSS galaxy BAO measurements combined with an analysis of the broadband power, including the Ly-alpha forest in BigBOSS quasar spectra, achieves a FOM of 395 with Planck plus Stage III priors. This FOM is based on conservative assumptions for the analysis of broad band power (k{sub max} = 0.15), and could grow to over 600 if current work allows us to push the analysis to higher wave numbers (k{sub max} = 0.3). BigBOSS will also place constraints on theories of modified gravity and inflation, and will measure the sum of neutrino masses to 0.024 eV accuracy.

  10. Tell Your Computer Who's Boss!

    ERIC Educational Resources Information Center

    Peterson, Franklynn; K-Turkel, Judi

    1983-01-01

    One training center overcomes "computerphobia" by using people-oriented trainers working one on one with the computer. People need to learn to be boss of their computers. Recommendations include: giving the computer a "dumb" name, and reading the manual every three months. (MD)

  11. Problematic Alcohol Use and Mild Intellectual Disability: Standardization of Pictorial Stimuli for an Alcohol Cue Reactivity Task

    ERIC Educational Resources Information Center

    van Duijvenbode, Neomi; Didden, Robert; Bloemsaat, Gijs; Engels, Rutger C. M. E.

    2012-01-01

    The present study focused on the first step in developing a cue reactivity task for studying cognitive biases in individuals with mild to borderline intellectual disability (ID) and alcohol use-related problems: the standardization of pictorial stimuli. Participants (N = 40), both with and without a history of alcohol use-related problems and…

  12. Auditory Evoked Potentials with Different Speech Stimuli: a Comparison and Standardization of Values

    PubMed Central

    Didoné, Dayane Domeneghini; Oppitz, Sheila Jacques; Folgearini, Jordana; Biaggio, Eliara Pinto Vieira; Garcia, Michele Vargas

    2016-01-01

    Introduction Long Latency Auditory Evoked Potentials (LLAEP) with speech sounds has been the subject of research, as these stimuli would be ideal to check individualś detection and discrimination. Objective The objective of this study is to compare and describe the values of latency and amplitude of cortical potentials for speech stimuli in adults with normal hearing. Methods The sample population included 30 normal hearing individuals aged between 18 and 32 years old with ontological disease and auditory processing. All participants underwent LLAEP search using pairs of speech stimuli (/ba/ x /ga/, /ba/ x /da/, and /ba/ x /di/. The authors studied the LLAEP using binaural stimuli at an intensity of 75dBNPS. In total, they used 300 stimuli were used (∼60 rare and 240 frequent) to obtain the LLAEP. Individuals received guidance to count the rare stimuli. The authors analyzed latencies of potential P1, N1, P2, N2, and P300, as well as the ampleness of P300. Results The mean age of the group was approximately 23 years. The averages of cortical potentials vary according to different speech stimuli. The N2 latency was greater for /ba/ x /di/ and P300 latency was greater for /ba/ x /ga/. Considering the overall average amplitude, it ranged from 5.35 and 7.35uV for different speech stimuli. Conclusion It was possible to obtain the values of latency and amplitude for different speech stimuli. Furthermore, the N2 component showed higher latency with the / ba / x / di / stimulus and P300 for /ba/ x / ga /. PMID:27096012

  13. The use of faces as stimuli in neuroimaging and psychological experiments: a procedure to standardize stimulus features.

    PubMed

    Gronenschild, Ed H B M; Smeets, Floortje; Vuurman, Eric F P M; van Boxtel, Martin P J; Jolles, Jelle

    2009-11-01

    In psychological experiments involving facial stimuli, it is of great importance that the basic perceptual or psychological characteristics that are investigated are not confounded by factors such as brightness and contrast, head size, hair cut and color, skin color, and the presence of glasses and earrings. Standardization of facial stimulus materials reduces the effect of these confounding factors. We therefore employed a set of basic image processing techniques to deal with this issue. The processed images depict the faces in grayscale, all at the same size, brightness, and contrast, and confined to an oval mask revealing only the basic features such as the eyes, nose, and mouth. The standardization was successfully applied to four different face databases, consisting of male and female faces and including neutral as well as happy facial expressions. An important advantage of the proposed standardization is that featural as well as configurational information is retained. We also consider the procedure to be a major contribution to the development of a de facto standard for the use of facial stimuli in psychological experiments. Such methodological standardization would allow a better comparison of the results of these studies. PMID:19897813

  14. North-American Norms for Name Disagreement: Pictorial Stimuli Naming Discrepancies

    PubMed Central

    O’Sullivan, Mary; Lepage, Martin; Bouras, Maria; Montreuil, Tina; Brodeur, Mathieu B.

    2012-01-01

    Pictorial stimuli are commonly used by scientists to explore central processes; including memory, attention, and language. Pictures that have been collected and put into sets for these purposes often contain visual ambiguities that lead to name disagreement amongst subjects. In the present work, we propose new norms which reflect these sources of name disagreement, and we apply this method to two sets of pictures: the Snodgrass and Vanderwart (S&V) set and the Bank of Standardized Stimuli (BOSS). Naming responses of the presented pictures were classified within response categories based on whether they were correct, incorrect, or equivocal. To characterize the naming strategy where an alternative name was being used, responses were further divided into different sub-categories that reflected various sources of name disagreement. Naming strategies were also compared across the two sets of stimuli. Results showed that the pictures of the S&V set and the BOSS were more likely to elicit alternative specific and equivocal names, respectively. It was also found that the use of incorrect names was not significantly different across stimulus sets but that errors were more likely caused by visual ambiguity in the S&V set and by a misuse of names in the BOSS. Norms for name disagreement presented in this paper are useful for subsequent research for their categorization and elucidation of name disagreement that occurs when choosing visual stimuli from one or both stimulus sets. The sources of disagreement should be examined carefully as they help to provide an explanation of errors and inconsistencies of many concepts during picture naming tasks. PMID:23133526

  15. Block Oriented Simulation System (BOSS)

    NASA Technical Reports Server (NTRS)

    Ratcliffe, Jaimie

    1988-01-01

    Computer simulation is assuming greater importance as a flexible and expedient approach to modeling system and subsystem behavior. Simulation has played a key role in the growth of complex, multiple access space communications such as those used by the space shuttle and the TRW-built Tracking and Data Relay Satellites (TDRS). A powerful new simulator for use in designing and modeling the communication system of NASA's planned Space Station is being developed. Progress to date on the Block (Diagram) Oriented Simulation System (BOSS) is described.

  16. Excitation Patterns of Standard and Steered Partial Tripolar Stimuli in Cochlear Implants.

    PubMed

    Wu, Ching-Chih; Luo, Xin

    2016-04-01

    Current steering in partial tripolar (pTP) mode has been shown to improve pitch perception and spectral resolution with cochlear implants (CIs). In this mode, a fraction (σ) of the main electrode current is returned within the cochlea and steered between the basal and apical flanking electrodes (with a proportion of α and 1 - α, respectively). Pitch generally decreases when α increases from 0 to 1, although the salience of pitch change varies across CI users. This study aimed to identify the mechanism of pitch changes with pTP-mode current steering and the factors contributing to the intersubject variability in pitch-ranking sensitivity. The electrical fields were measured for steered pTP stimuli on the same main electrode with α = 0, 0.5, and 1 in five implanted ears using electrical field imaging (EFI). The related excitation patterns were also measured physiologically using evoked compound action potential (ECAP) and psychophysically using psychophysical forward masking (PFM). Consistent with the pitch-ranking results in this study, the EFI, ECAP, and PFM centroids shifted apically with increasing α. An apical shift was also observed for the PFM peak but not for the EFI or ECAP peak. The pattern width was similar with different α values within a given measure (e.g., EFI, ECAP, or PFM), but the ECAP patterns were broader than the EFI and PFM patterns, possibly because ECAP was measured with smaller σ values than EFI and PFM. The amount of pattern shift with α depended on σ (i.e., the total amount of current used for steering) but was not correlated with the pitch-ranking sensitivity across subjects. The results revealed that the pitch changes elicited by pTP-mode current steering were not only driven by the shifts of excitation centroid. PMID:26691160

  17. Do Rare Stimuli Evoke Large P3s by Being Unexpected? A Comparison of Oddball Effects Between Standard-Oddball and Prediction-Oddball Tasks

    PubMed Central

    Verleger, Rolf; Śmigasiewicz, Kamila

    2016-01-01

    The P3 component of event-related potentials increases when stimuli are rarely presented. It has been assumed that this oddball effect (rare-frequent difference) reflects the unexpectedness of rare stimuli. The assumption of unexpectedness and its link to P3 amplitude were tested here. A standard- oddball task requiring alternative key-press responses to frequent and rare stimuli was compared with an oddball-prediction task where stimuli had to be first predicted and then confirmed by key-pressing. Oddball effects in the prediction task depended on whether the frequent or the rare stimulus had been predicted. Oddball effects on P3 amplitudes and error rates in the standard oddball task closely resembled effects after frequent predictions. This corroborates the notion that these effects occur because frequent stimuli are expected and rare stimuli are unexpected. However, a closer look at the prediction task put this notion into doubt because the modifications of oddball effects on P3 by expectancies were entirely due to effects on frequent stimuli, whereas the large P3 amplitudes evoked by rare stimuli were insensitive to predictions (unlike response times and error rates). Therefore, rare stimuli cannot be said to evoke large P3 amplitudes because they are unexpected. We discuss these diverging effects of frequency and expectancy, as well as general differences between tasks, with respect to concepts and hypotheses about P3b’s function and conclude that each discussed concept or hypothesis encounters some problems, with a conception in terms of subjective relevance assigned to stimuli offering the most consistent account of these basic effects. PMID:27512527

  18. PREFACE: Stimuli Stimuli

    NASA Astrophysics Data System (ADS)

    Queisser, Hans J.

    2011-01-01

    Tributes are paid to Zhores Alferov by presenting personal anecdotes from the fields, where Alferov performed his pioneering research: masers, lasers, solar cells and heterojunctions. What a pleasure and honor to pay tribute to Zhores Alferov in this Festschrift. Member of a remarkable laboratory and originator of imaginative and useful ideas for semiconductor physics and technology; a happy birthday! I would like to use this opportunity to ramble a little about the physics of masers, lasers, heterojunctions, solar cells— all themes of such vital importance in Alferov's career—and also tangible in my own endeavors. I start out with an anecdote of a colloquium presentation in my youthful days at Göttingen. The Physics Colloquium at Göttingen University presented a serious weekly meeting. Werner Heisenberg and Carl Friedrich von Weizsäcker attended, often Wolfgang Pauli visited from Zurich; Otto Hahn always sat in the first row, on the left corner— and he smoked his cigar. I had just obtained my doctorate [1]— it was 1958, and my boss Rudolf Hilsch ordered me to contribute a colloquium talk. He hoped that I would report on color centers in alkali halides or review experiments on quenched amorphous bismuth, a surprising superconductor [2], or on my own dissertation [1], all recent results of our team. I, however, being an avid reader of the latest American physics literature, begged to differ. The English language gave me no problems because I had in 1951/52 spent a year at the University of Kansas. This experience in the friendly American Midwest provided me with a definite linguistic advantage over most of my German fellow students. I was fascinated by those very first reports on the maser, this molecular amplifier using ammonia for stimulated emission, and therefore decided, quite to the chagrin of my boss Hilsch, to choose this particular topic for a report at the Colloquium. So I went to the rostrum in the small auditorium 'Hörsaal II' and delivered a

  19. Can Agitated Behavior of Nursing Home Residents with Dementia be Prevented With the Use of Standardized Stimuli?

    PubMed Central

    Cohen-Mansfield, Jiska; Marx, Marcia S.; Dakheel-Ali, Maha; Regier, Natalie G.; Thein, Khin; Freedman, Laurence

    2010-01-01

    Objectives The objective of this paper was to assess the relative impact of different types of stimuli on agitated behaviors of nursing home residents with dementia. Design Setting/Participants Participants were 111 residents of 7 Maryland nursing homes with a diagnosis of dementia who exhibited agitation. Intervention Different types of stimuli (music, social stimuli, simulated social stimuli, and individualized stimuli based on the person’s self-identity) to prevent behavior problems. Measurements Agitation was directly observed and recorded via the Agitated Behaviors Mapping Instrument. Results All stimulus categories were associated with significantly less physical agitation than baseline observations, and all except for manipulative stimuli were associated with significantly less total agitation. Live social stimuli were associated with less agitation than music, self-identity, work, simulated social, and manipulative stimulus categories. Task and reading stimulus categories were each associated with significantly less agitation than work, simulated social, and manipulative stimulus categories. Music and self-identity stimuli were associated with less agitation than simulated social and manipulative stimuli. Conclusion Providing stimuli offers a proactive approach to preventing agitation in persons with dementia, with live social stimuli being most successful. PMID:20579167

  20. Thermal resistances of solder-boss/potting compound combinations

    NASA Technical Reports Server (NTRS)

    Veilleux, E. D.

    1968-01-01

    Formulas, which can be used as a design tool, are derived to calculate the thermal resistance of solder-boss/potting compound combinations, for different depths of a solder boss, in electronic cordwood modules. Since the solder boss is the heat source, its shape and position will affect the thermal resistance of the surrounding potting compound.

  1. PREFACE: Stimuli Stimuli

    NASA Astrophysics Data System (ADS)

    Queisser, Hans J.

    2011-01-01

    Tributes are paid to Zhores Alferov by presenting personal anecdotes from the fields, where Alferov performed his pioneering research: masers, lasers, solar cells and heterojunctions. What a pleasure and honor to pay tribute to Zhores Alferov in this Festschrift. Member of a remarkable laboratory and originator of imaginative and useful ideas for semiconductor physics and technology; a happy birthday! I would like to use this opportunity to ramble a little about the physics of masers, lasers, heterojunctions, solar cells— all themes of such vital importance in Alferov's career—and also tangible in my own endeavors. I start out with an anecdote of a colloquium presentation in my youthful days at Göttingen. The Physics Colloquium at Göttingen University presented a serious weekly meeting. Werner Heisenberg and Carl Friedrich von Weizsäcker attended, often Wolfgang Pauli visited from Zurich; Otto Hahn always sat in the first row, on the left corner— and he smoked his cigar. I had just obtained my doctorate [1]— it was 1958, and my boss Rudolf Hilsch ordered me to contribute a colloquium talk. He hoped that I would report on color centers in alkali halides or review experiments on quenched amorphous bismuth, a surprising superconductor [2], or on my own dissertation [1], all recent results of our team. I, however, being an avid reader of the latest American physics literature, begged to differ. The English language gave me no problems because I had in 1951/52 spent a year at the University of Kansas. This experience in the friendly American Midwest provided me with a definite linguistic advantage over most of my German fellow students. I was fascinated by those very first reports on the maser, this molecular amplifier using ammonia for stimulated emission, and therefore decided, quite to the chagrin of my boss Hilsch, to choose this particular topic for a report at the Colloquium. So I went to the rostrum in the small auditorium 'Hörsaal II' and delivered a

  2. Dorsal wrist mass: the carpal boss.

    PubMed

    Boggess, Blake; Berkoff, David

    2011-01-01

    The carpal boss is an osseous overgrowth that is occasionally mistaken for a ganglion cyst. This report highlights the case a 36-year-old patient who was originally diagnosed by his primary care physician with a ganglion cyst and was sent to an orthopaedist for aspiration. Upon further evaluation with a plain radiograph, the dorsal wrist mass was found to be a carpal boss. The patient was treated with rest and a wrist brace, and was informed that a corticosteroid injection or surgical excision would be necessary if conservative treatment failed. The patient was asymptomatic on follow-up and invasive procedures were not necessary. PMID:22707539

  3. Dream Catchers: "Margin Call," "Boss," and Climbing the Beanstalk

    ERIC Educational Resources Information Center

    Beck, Bernard

    2012-01-01

    Two recent popular entertainments, "Margin Call" (Barnum, Dodson, Jenckes, Moosa, Quinto & Chandor, 2011) and "Boss" (Safinia, 2011), depict powerful and successful groups of bosses confronting sudden, extreme threats. They are forced to react quickly and sacrifice important values to achieve survival of their organizations. In these emergencies,…

  4. Diagnosis and Treatment of Symptomatic Carpal Bossing

    PubMed Central

    Radmer, Sebastian; Fresow, Robert; Tabibzada, Arash Mehdi; Kamusella, Peter; Scheer, Fabian; Andresen, Reimer

    2015-01-01

    Context Carpal bossing is an osseous formation at the dorsal portion of the quadrangular joint, which rarely becomes symptomatic. However, in some patients it causes pain, restricted mobility and can lead to complications like tendon rupture, inflammatory and degenerative joint disease. Aim In this article, we present our experiences with this rare disorder in order to improve diagnostic and therapeutic proceedings. Settings Design This is a multicenter and interdisciplinary observation made by orthopaedic surgeons and radiologists in the years 2010 to 2015. Retrospective observational study. The follow up period was 2 years. Materials and Methods In the observed time period, eight patients were diagnosed with symptomatic carpal bossing. Symptoms were pain at palmar flexion and limited mobility of the wrist in combination with a palpable protuberance over the quadrangular joint. All patients underwent X-ray, CT and MRI examinations. A conservative treatment strategy was initiated for 6 weeks in all patients, followed by a wedge resection when symptoms were persisting and disabling. Results After the conservative treatment schedule, five patients were asymptomatic. Three patients had persisting pain and were thus recommended for surgery. In the postoperative course, two patients were asymptomatic. One patient developed a type 1 complex regional pain syndrome (CRPS) in the first postoperative year, which was successfully treated with pain-adapted physiotherapy, pharmacotherapy with analgesics and calcitonin, and a triple CT-guided thoracic sympathetic nerve blockade. Conclusion Carpal bossing is a mostly asymptomatic entity, which in our experience gets symptomatic due to direct trauma or repetitive stress, especially in competitive racket sports players. It can be diagnosed by thorough clinical examination and multimodal diagnostic imaging. Conservative treatment comprises an excellent prognosis, however surgery, either wedge resection or arthrodesis, must be

  5. Gender differences in the processing of standard emotional visual stimuli: integrating ERP and fMRI results

    NASA Astrophysics Data System (ADS)

    Yang, Lei; Tian, Jie; Wang, Xiaoxiang; Hu, Jin

    2005-04-01

    The comprehensive understanding of human emotion processing needs consideration both in the spatial distribution and the temporal sequencing of neural activity. The aim of our work is to identify brain regions involved in emotional recognition as well as to follow the time sequence in the millisecond-range resolution. The effect of activation upon visual stimuli in different gender by International Affective Picture System (IAPS) has been examined. Hemodynamic and electrophysiological responses were measured in the same subjects. Both fMRI and ERP study were employed in an event-related study. fMRI have been obtained with 3.0 T Siemens Magnetom whole-body MRI scanner. 128-channel ERP data were recorded using an EGI system. ERP is sensitive to millisecond changes in mental activity, but the source localization and timing is limited by the ill-posed 'inversed' problem. We try to investigate the ERP source reconstruction problem in this study using fMRI constraint. We chose ICA as a pre-processing step of ERP source reconstruction to exclude the artifacts and provide a prior estimate of the number of dipoles. The results indicate that male and female show differences in neural mechanism during emotion visual stimuli.

  6. Extreme Red Quasars in SDSS-BOSS

    NASA Astrophysics Data System (ADS)

    Hamann, Fred; Zakamska, Nadia; Paris, Isabelle; Herbst, Hanna; Villforth, Carolin; Alexandroff, Rachael; Ross, Nicholas; Greene, Jenny; Strauss, Michael

    2015-08-01

    Red quasars are believed to mark a critical transition stage of massive galaxy evolution when a blowout of gas and dust truncates the initial starburst and provides our first visible views of a luminous central AGN. Red quasars could therefore have unusual properties associated with a young evolution stage, such as higher accretion rates, higher rates of mergers and interactions, and more common or more powerful outflows capable of driving a galaxy-wide blowout (e.g., compared to normal blue quasars in presumably more evolved galaxy hosts). The recently completed Baryon Oscillation Spectroscopy Survey (BOSS) of SDSS-III has discovered many more faint quasars with higher redshifts and redder colors than any previous large survey. We combine BOSS spectra with SDSS and Wide-Field Infrared Survey Explorer (WISE) photometry of nearly 100,000 quasars to identify and characterize the red quasar population at redshifts >2. We find a number of strong trends with the amount of reddening/obscuration. For example, red quasars are 5 to 8 times more likely to have broad absorption lines and other "intrinsic" absorption lines that identify quasar-driven outflows. Perhaps most interesting is that extreme red quasars (ERQs), selected via rest-frame UV to near-IR colors similar to Dust Obscured Galaxies (DOGs), have uniquely exotic emission line properties that include extreme velocity shifts between lines and the broadest and most blueshifted [OIII] lines yet discovered (with FWHMs reaching >3000 km/s). We will discuss the implications of these results for models of the structure and evolution of quasars and their host galaxy environments.

  7. A Spectrograph for BigBOSS

    NASA Astrophysics Data System (ADS)

    CARTON, Pierre-Henri; Bebek, C.; Cazaux, S.; Ealet, A.; Eppelle, D.; Kneib, J.; Karst, P.; levi, M.; magneville, C.; Palanque-Delabrouille, N.; Ruhlmann-Kleider, V.; Schlegel, D.; Yeche, C.

    2012-01-01

    The Big-Boss spectrographs assembly will take in charge the light from the fiber output to the detector, including the optics, gratings, mechanics and cryostats. The 5000 fibers are split in 10 bundles of 500 ones. Each of these channel feed one spectrograph. The full bandwidth from 0.36µm to 1.05µm is split in 3 bands. Each channel is composed with one collimator (doublet lenses), a VPH grating, and a 6 lenses camera. The 500 fiber spectrum are imaged onto a 4kx4k detector thanks to the F/2 camera. Each fiber core is imaged onto 4 pixels. Each channel of the BigBOSS spectrograph will be equipped with a single-CCD camera, resulting in 30 cryostats in total for the instrument. Based on its experience of CCD cameras for projects like EROS and MegaCam, CEA/Saclay has designed small and autonomous cryogenic vessels which integrate cryo-cooling, CCD positioning and slow control interfacing capabilities. The use of a Linear Pulse Tube with its own control unit, both developed by Thales Cryogenics BV, will ensure versatility, reliability and operational flexibility. CCD's will be cooled down to 140K, with stability better than 1K. CCD's will be positioned within 15µm along the optical axis and 50µm in the XY Plan. Slow Control machines will be directly interfaced to an Ethernet network, which will allow them to be operated remotely. The concept of spectrograph leads to a very robust concept without any mechanics (except the shutters). This 30 channels has a impressive compactness with its 3m3 volume. The development of such number of channel will drive to a quasi mass production philosophy.

  8. What BOSS has taught us about Quasars.

    NASA Astrophysics Data System (ADS)

    Ross, Nicholas; SDSS-III BOSS Quasar Science Working Group

    2015-01-01

    This talk presents science highlights from the SDSS-III BOSS Quasar Survey, which has obtained spectra for over 300,000 quasars, 200,000 of which are at redshift z>2. Using this dataset, new measurements of the luminosity function have been made, with the faint end of the luminosity function now measured to z~5. New clustering results from DR12 are presented, and the weak luminosity dependence of quasar clustering at z~0.5 is also discussed.New studies of the broad absorption line (BAL) quasar population have also been performed, with a sample of BAL quasars from the original SDSS being re-observed. These new data have shown the disappearance of CIV BAL troughs and indeed the transformation of BAL QSOs to non-BAL QSOs. BAL disappearance, and emergence, events appear to be extremes of general BAL variability, and have shed light on accretion-disk wind models.We highlight the discovery of new classes of quasars including: a population of broad-line Mg II emitters found in a passive galaxy sample; objects with extremely red optical-to-mid infrared colors; objects with very curious UV line (LyA:NV) ratios and potentially the long-sought after high-redshift Type 2 Quasar population.Finally, we describe two new dedicated programs, one focusing on reverberation mapping, the other on X-ray selected quasars.A full list of papers connected to the BOSS Quasar Survey is given at: http://www.sdss3.org/science/publications.php

  9. SDSS-IV eBOSS emission-line galaxy pilot survey

    NASA Astrophysics Data System (ADS)

    Comparat, J.; Delubac, T.; Jouvel, S.; Raichoor, A.; Kneib, J.-P.; Yèche, C.; Abdalla, F. B.; Le Cras, C.; Maraston, C.; Wilkinson, D. M.; Zhu, G.; Jullo, E.; Prada, F.; Schlegel, D.; Xu, Z.; Zou, H.; Bautista, J.; Bizyaev, D.; Bolton, A.; Brownstein, J. R.; Dawson, K. S.; Escoffier, S.; Gaulme, P.; Kinemuchi, K.; Malanushenko, E.; Malanushenko, V.; Mariappan, V.; Newman, J. A.; Oravetz, D.; Pan, K.; Percival, W. J.; Prakash, A.; Schneider, D. P.; Simmons, A.; Abbott, T. M. C.; Allam, S.; Banerji, M.; Benoit-Lévy, A.; Bertin, E.; Brooks, D.; Capozzi, D.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; Castander, F. J.; Cunha, C. E.; da Costa, L. N.; Desai, S.; Doel, P.; Eifler, T. F.; Estrada, J.; Flaugher, B.; Fosalba, P.; Frieman, J.; Gaztanaga, E.; Gerdes, D. W.; Gruen, D.; Gruendl, R. A.; Gutierrez, G.; Honscheid, K.; James, D. J.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Lima, M.; Maia, M. A. G.; March, M.; Marshall, J. L.; Miquel, R.; Plazas, A. A.; Reil, K.; Roe, N.; Romer, A. K.; Roodman, A.; Rykoff, E. S.; Sako, M.; Sanchez, E.; Scarpine, V.; Sevilla-Noarbe, I.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thaler, J.; Thomas, D.; Walker, A. R.; Zhang, Y.

    2016-08-01

    The Sloan Digital Sky Survey IV extended Baryonic Oscillation Spectroscopic Survey (SDSS-IV/eBOSS) will observe 195 000 emission-line galaxies (ELGs) to measure the baryonic acoustic oscillation (BAO) standard ruler at redshift 0.9. To test different ELG selection algorithms, 9000 spectra were observed with the SDSS spectrograph as a pilot survey based on data from several imaging surveys. First, using visual inspection and redshift quality flags, we show that the automated spectroscopic redshifts assigned by the pipeline meet the quality requirements for a reliable BAO measurement. We also show the correlations between sky emission, signal-to-noise ratio in the emission lines, and redshift error. Then we provide a detailed description of each target selection algorithm we tested and compare them with the requirements of the eBOSS experiment. As a result, we provide reliable redshift distributions for the different target selection schemes we tested. Finally, we determine an target selection algorithms that is best suited to be applied on DECam photometry because they fulfill the eBOSS survey efficiency requirements. The catalog is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/592/A121

  10. Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

    PubMed

    Duffy, Darragh; Rouilly, Vincent; Libri, Valentina; Hasan, Milena; Beitz, Benoit; David, Mikael; Urrutia, Alejandra; Bisiaux, Aurélie; Labrie, Samuel T; Dubois, Annick; Boneca, Ivo G; Delval, Cécile; Thomas, Stéphanie; Rogge, Lars; Schmolz, Manfred; Quintana-Murci, Lluis; Albert, Matthew L

    2014-03-20

    Standardization of immunophenotyping procedures has become a high priority. We have developed a suite of whole-blood, syringe-based assay systems that can be used to reproducibly assess induced innate or adaptive immune responses. By eliminating preanalytical errors associated with immune monitoring, we have defined the protein signatures induced by (1) medically relevant bacteria, fungi, and viruses; (2) agonists specific for defined host sensors; (3) clinically employed cytokines; and (4) activators of T cell immunity. Our results provide an initial assessment of healthy donor reference values for induced cytokines and chemokines and we report the failure to release interleukin-1α as a common immunological phenotype. The observed naturally occurring variation of the immune response may help to explain differential susceptibility to disease or response to therapeutic intervention. The implementation of a general solution for assessment of functional immune responses will help support harmonization of clinical studies and data sharing. PMID:24656047

  11. Emotional reactions to standardized stimuli in women with borderline personality disorder: stronger negative affect, but no differences in reactivity.

    PubMed

    Jacob, Gitta A; Hellstern, Kathrin; Ower, Nicole; Pillmann, Mona; Scheel, Corinna N; Rüsch, Nicolas; Lieb, Klaus

    2009-11-01

    Emotional dysregulation is hypothesized to be a core feature of borderline personality disorder (BPD). In this study, we investigated the course of emotions in response to standardized emotion inductions in BPD. A total of 26 female BPD patients, 28 matched healthy control subjects, and 15 female patients with major depressive disorder listened to short stories inducing an angry, joyful, or neutral mood. Before and immediately after each story as well as 3 and 6 minutes later, participants rated their current anger, joy, anxiety, shame, and sadness. All 3 groups showed the same increase and decrease of emotions. However, strong group differences in the general level of all negative emotions occurred. While sadness was stronger both in BPD and major depressive disorder as compared with healthy controls, all other negative emotions were significantly increased in BPD only independent of comorbid depression. Extreme negative affectivity may be a more appropriate description of BPD-related emotional problems than emotional hyperreactivity. PMID:19996718

  12. Revised cosmological parameters after BICEP 2 and BOSS

    NASA Astrophysics Data System (ADS)

    Das, Santanu; Mukherjee, Suvodip; Souradeep, Tarun

    2015-02-01

    Estimation of parameters of the 'standard' model of cosmology have dramatically improved over past few decades due to increasingly exquisite measurements made by Cosmic Microwave Background (CMB) experiments. Recent data from Planck matches well with the minimal ΛCDM model. A likelihood analysis using Planck, WMAP and a selection of high resolution experiments (highL), tensor to scalar ratio r0.002 is found to be <0.11 when dns/d ln k = 0. Planck also imposes an upper bound on neutrino mass ∑ mν<0.23 eV using Planck + WMAP + highL + BAO likelihood. However, recently results from BICEP 2 claims the detection of r= 0.2+0.07-0.05 from polarization spectra. Further, results from SDSS-III BOSS large scale galaxy survey constrains the total neutrino mass to ∑ mν=0.36 ± 0.10 eV . It is important to study the consequences of these new measurements on other cosmological parameters. In this paper we assess the revised constraints on cosmological parameters in light of these two measurements that are in some tension with the constraints from Planck. The sensitivity of Planck to weak lensing effect on the CMB angular power spectrum suggests that the normalized amplitude of physical lensing power AL > 1 at 2σ hints at a potentially important internal inconsistency. Therefore, we also include a study of the constraints on AL. Using the prior on ∑ mν as measured by SDSS-III BOSS and BICEP 2 likelihood, we find that the model with running spectral index (dns/d ln k ≠ 0) leads to a value of AL>1 at 3.1 σ. But, the model with dns/d ln k =0 makes AL consistent with 1, at 2.1σ and also shows that Neff is consistent with its theoretical value of 3.046 at around 2σ. Therefore, the analysis in this paper shows that the model with dns/d ln k =0 gives consistency with other cosmological parameters (Neff and AL ) when the current limits on ∑ mν and r0.05 are considered. However, on reducing the value of r0.05, the model with non-zero dns/d ln k gives consistent result of

  13. Are you a good boss--or a great one?

    PubMed

    Hill, Linda A; Lineback, Kent

    2011-01-01

    Private moments of doubt and fear come even to managers who have spent years on the job. Any number of events can trigger them: an initiative going poorly, a lukewarm performance review, a daunting new assignment. HBS professor Hill and executive Lineback have long studied the question of how manager grow and advance. Their experience brings them to a simple but troubling observation: Most bosses reach a certain level of proficiency and stay there--short of what they could and should be. Why? Because they stop working on themselves. The authors offer what they call the three imperatives for managers who seek to avoid this stagnation. First, manage yourself--who you are as a person, the beliefs and values that drive your actions, and especially how you connect with others all matter to the people you must influence. Second, manage your network. Effective managers know that they cannot avoid conflict and competition among organizational groups; they build and nurture ongoing relationships. Third, manage your team. Team members need to know what's required of them collectively and individually and what the team's values, norms, and standards are. The authors include a useful assessment tool to help readers get started. PMID:21370809

  14. The carpal boss: a review of different sonographic findings*

    PubMed Central

    Arend, Carlos Frederico

    2014-01-01

    Carpal boss is an uncommon condition whose incidence is underestimated and that is frequently confused with other causes of development of tumor-like lesions on the dorsum of the wrist. From the clinical point of view, the main obstacle to its recognition is the nonspecificity of symptoms, frequently attributed to dorsal ganglion cysts, since both conditions share a similar location on the dorsum of the wrist. The assessment by ultrasonography allows for a correct diagnosis and appropriate management, with better chances of resolution of the clinical complaint and lower probability of iatrogenic worsening of the lesion. The present review is aimed at describing the different sonographic findings of carpal boss. PMID:25741059

  15. The carpal boss: a review of different sonographic findings.

    PubMed

    Arend, Carlos Frederico

    2014-01-01

    Carpal boss is an uncommon condition whose incidence is underestimated and that is frequently confused with other causes of development of tumor-like lesions on the dorsum of the wrist. From the clinical point of view, the main obstacle to its recognition is the nonspecificity of symptoms, frequently attributed to dorsal ganglion cysts, since both conditions share a similar location on the dorsum of the wrist. The assessment by ultrasonography allows for a correct diagnosis and appropriate management, with better chances of resolution of the clinical complaint and lower probability of iatrogenic worsening of the lesion. The present review is aimed at describing the different sonographic findings of carpal boss. PMID:25741059

  16. Revised cosmological parameters after BICEP 2 and BOSS

    SciTech Connect

    Das, Santanu; Mukherjee, Suvodip; Souradeep, Tarun E-mail: suvodip@iucaa.ernet.in

    2015-02-01

    Estimation of parameters of the 'standard' model of cosmology have dramatically improved over past few decades due to increasingly exquisite measurements made by Cosmic Microwave Background (CMB) experiments. Recent data from Planck matches well with the minimal ΛCDM model. A likelihood analysis using Planck, WMAP and a selection of high resolution experiments (highL), tensor to scalar ratio r{sub 0.002} is found to be <0.11 when dn{sub s}/dln k = 0. Planck also imposes an upper bound on neutrino mass ∑ m{sub ν}<0.23 eV using Planck + WMAP + highL + BAO likelihood. However, recently results from BICEP 2 claims the detection of r= 0.2{sup +0.07}{sub −0.05} from polarization spectra. Further, results from SDSS-III BOSS large scale galaxy survey constrains the total neutrino mass to ∑ m{sub ν}=0.36 ± 0.10 eV . It is important to study the consequences of these new measurements on other cosmological parameters. In this paper we assess the revised constraints on cosmological parameters in light of these two measurements that are in some tension with the constraints from Planck. The sensitivity of Planck to weak lensing effect on the CMB angular power spectrum suggests that the normalized amplitude of physical lensing power A{sub L} > 1 at 2σ hints at a potentially important internal inconsistency. Therefore, we also include a study of the constraints on A{sub L}. Using the prior on ∑ m{sub ν} as measured by SDSS-III BOSS and BICEP 2 likelihood, we find that the model with running spectral index (dn{sub s}/dln k ≠ 0) leads to a value of A{sub L}>1 at 3.1 σ. But, the model with dn{sub s}/dln k =0 makes A{sub L} consistent with 1, at 2.1σ and also shows that N{sub eff} is consistent with its theoretical value of 3.046 at around 2σ. Therefore, the analysis in this paper shows that the model with dn{sub s}/dln k =0 gives consistency with other cosmological parameters (N{sub eff} and A{sub L} ) when the current limits on ∑ m{sub

  17. Conservative management of symptomatic Carpal Bossing in an elite hockey player: a case report

    PubMed Central

    Kissel, Peter

    2009-01-01

    Objective: To present the characteristics and create awareness of symptomatic carpal bossing and discuss potential etiologies and the role of conservative management through the presentation of an athlete with traumatic onset of symptomatic carpal bossing. Clinical features: This case report outlines the presentation and conservative management of an elite eighteen year old hockey player with symptomatic carpal bossing after a traumatic on ice collision. Carpal bossing is a bony, dorsal prominence in the quadrangular joint of the wrist that is inconsistently symptomatic. Intervention and outcome: A conservative treatment plan consisting of education, reassurance, avoidance of aggravation, and soft tissue therapy allowed return to play in two weeks without restrictions or need for surgical consultation. Conclusion: With inconsistent recurrence rates and surgical complications, the role of conservative management for symptomatic carpal bossing deserves further exploration. The conservative practitioner should be aware of the signs and symptoms of symptomatic carpal bossing to institute suitable treatment. PMID:20037693

  18. Integrating BigBOSS with the Mayall Telescope

    NASA Astrophysics Data System (ADS)

    Besuner, Robert; Bebek, Chris; Dey, Arjun; Goble, Will; Joyce, Dick; Levi, Michael E.; Reil, Kevin; Schlegel, David; Sholl, Michael

    2012-09-01

    BigBOSS is a proposed ground-based dark energy experiment to study baryon acoustic oscillations (BAO) and the growth of large scale structure. It consists of a fiber-fed multi-object spectrograph designed to be installed on the Mayall 4-meter telescope at Kitt Peak, Arizona. BigBOSS includes an optical corrector assembly and 5000-fiber-positioner focal plane assembly that replace the existing Mayall prime focus hardware. 40-meter long optical fiber bundles are routed from the focal plane, through the telescope declination and right ascension pivots, to spectrographs in the thermally insulated FTS Laboratory, immediately adjacent to the telescope. Each of the ten spectrographs includes three separate spectral bands. The FTS Laboratory also houses support electronics, cooling, and vacuum equipment. The prime focus assembly includes mounts for the existing Mayall f/8 secondary mirror to allow observations with Cassegrain instruments. We describe the major elements of the BigBOSS instrument, plans for integrating with the Telescope, and proposed modifications and additions to existing Mayall facilities.

  19. Cosmology from the BOSS Lyman-Alpha Forest

    NASA Astrophysics Data System (ADS)

    Font-Ribera, Andreu; SDSS-III Collaboration

    2015-01-01

    After six years of observations, the Baryon Oscillation Spectroscopic Survey (BOSS) ended last summer, and recently made its data public (SDSS Data Release 12). During these years, it has used the SDSS telescope to obtain spectra of 1.5 million galaxies to get very accurate measurements of the Baryon Acoustic Oscillations (BAO) scale at redshift z ~0.5. At the same time, BOSS observed over 184 000 high redshift quasars (z>2.15) with the goal of detecting the BAO feature in the clustering of the intergalactic medium, using a technique known as the Lyman alpha forest (LyaF).In this talk I will overview several results from the LyaF working group in BOSS, including the measurement of BAO at z=2.4 both from the auto-correlation of the LyaF (Delubac et al. 2014), and from its cross-correlation with quasars (Font-Ribera et al. 2014). From the combination of these studies we are able to measure the expansion rate of the Universe 11 billion years ago with a 2% uncertainty.

  20. Extremely red quasars from SDSS, BOSS and WISE: classification of optical spectra

    NASA Astrophysics Data System (ADS)

    Ross, Nicholas P.; Hamann, Fred; Zakamska, Nadia L.; Richards, Gordon T.; Villforth, Carolin; Strauss, Michael A.; Greene, Jenny E.; Alexandroff, Rachael; Brandt, W. Niel; Liu, Guilin; Myers, Adam D.; Pâris, Isabelle; Schneider, Donald P.

    2015-11-01

    Quasars with extremely red infrared-to-optical colours are an interesting population that can test ideas about quasar evolution as well as orientation, obscuration and geometric effects in the so-called AGN unified model. To identify such a population, we match the quasar catalogues of the Sloan Digital Sky Survey (SDSS), the Baryon Oscillation Spectroscopic Survey (BOSS) to the Wide-Field Infrared Survey Explorer (WISE) to identify quasars with extremely high infrared-to-optical ratios. We identify 65 objects with rAB - W4Vega > 14 mag (i.e. Fν(22 μm)/Fν(r) ≳ 1000). This sample spans a redshift range of 0.28 < z < 4.36 and has a bimodal distribution, with peaks at z ˜ 0.8 and z ˜ 2.5. It includes three z > 2.6 objects that are detected in the W4 band but not W1 or W2 (i.e. `W1W2 dropouts'). The SDSS/BOSS spectra show that the majority of the objects are reddened type 1 quasars, type 2 quasars (both at low and high redshift) or objects with deep low-ionization broad absorption lines (BALs) that suppress the observed r-band flux. In addition, we identify a class of type 1 permitted broad emission-line objects at z ≃ 2-3 which are characterized by emission line rest-frame equivalent widths (REWs) of ≳150 Å, much larger than those of typical quasars. In particular, 55 per cent (45 per cent) of the non-BAL type 1s with measurable C IV in our sample have REW(C IV) > 100 (150) Å, compared to only 5.8 per cent (1.3 per cent) for non-BAL quasars in BOSS. These objects often also have unusual line ratios, such as very high N V/Ly α ratios. These large REWs might be caused by suppressed continuum emission analogous to type 2 quasars; however, there is no obvious mechanism in standard unified models to suppress the continuum without also obscuring the broad emission lines.

  1. 77 FR 3500 - Hugo Boss Cleveland, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Cleveland, Inc., Brooklyn, Ohio. The notice was published in the Federal Register on May 5, 2010 (75 FR... Employment and Training Administration Hugo Boss Cleveland, Inc., Including Workers Whose Unemployment... location of Hugo Boss Cleveland, Inc. had their wages reported under a separate unemployment insurance...

  2. Skin surface lipids of the domestic chicken, and neutral lipid standards as stimuli for the penetration response of Austrobilharzia variglandis cercariae.

    PubMed

    Zibulewsky, J; Fried, B; Bacha, W J

    1982-10-01

    Lipids were extracted from the skin of 2-wk-old domestic chickens using sterile cotton gauze dampened with chloroform:methanol (2:1). Preparative thin-layer chromatography separated the skin lipids into six major fractions: phospholipids, free sterols, free fatty acids, triglycerides, methyl esters, sterol esters. The penetration response of the marine avian schistosome cercaria, Austrobilharzia variglandis, to chicken skin lipid fractions, and to neutral lipid standards, was tested by coating lipids on agar in a Petri dish containing a seawater overlay. All neutral lipids tested produced significantly greater penetration responses than the chloroform control. The phospholipid skin fraction killed cercariae. Lipid from whole chicken skin produced the greatest penetration response, followed by free fatty acids and free sterol skin fractions. Of the standards tested, the whole neutral lipid standard, containing cholesterol, oleic acid, triolein, methyl oleate, and cholesteryl oleate, produced the greatest response, followed by the cholesterol standard and the oleic acid standard. PMID:7131196

  3. Effective Stimuli for Constructing Reliable Neuron Models

    PubMed Central

    Druckmann, Shaul; Berger, Thomas K.; Schürmann, Felix; Hill, Sean; Markram, Henry; Segev, Idan

    2011-01-01

    The rich dynamical nature of neurons poses major conceptual and technical challenges for unraveling their nonlinear membrane properties. Traditionally, various current waveforms have been injected at the soma to probe neuron dynamics, but the rationale for selecting specific stimuli has never been rigorously justified. The present experimental and theoretical study proposes a novel framework, inspired by learning theory, for objectively selecting the stimuli that best unravel the neuron's dynamics. The efficacy of stimuli is assessed in terms of their ability to constrain the parameter space of biophysically detailed conductance-based models that faithfully replicate the neuron's dynamics as attested by their ability to generalize well to the neuron's response to novel experimental stimuli. We used this framework to evaluate a variety of stimuli in different types of cortical neurons, ages and animals. Despite their simplicity, a set of stimuli consisting of step and ramp current pulses outperforms synaptic-like noisy stimuli in revealing the dynamics of these neurons. The general framework that we propose paves a new way for defining, evaluating and standardizing effective electrical probing of neurons and will thus lay the foundation for a much deeper understanding of the electrical nature of these highly sophisticated and non-linear devices and of the neuronal networks that they compose. PMID:21876663

  4. Attention samples stimuli rhythmically.

    PubMed

    Landau, Ayelet Nina; Fries, Pascal

    2012-06-01

    Overt exploration or sampling behaviors, such as whisking, sniffing, and saccadic eye movements, are often characterized by a rhythm. In addition, the electrophysiologically recorded theta or alpha phase predicts global detection performance. These two observations raise the intriguing possibility that covert selective attention samples from multiple stimuli rhythmically. To investigate this possibility, we measured change detection performance on two simultaneously presented stimuli, after resetting attention to one of them. After a reset flash at one stimulus location, detection performance fluctuated rhythmically. When the flash was presented in the right visual field, a 4 Hz rhythm was directly visible in the time courses of behavioral performance at both stimulus locations, and the two rhythms were in antiphase. A left visual field flash exerted only partial reset on performance and induced rhythmic fluctuation at higher frequencies (6-10 Hz). These findings show that selective attention samples multiple stimuli rhythmically, and they position spatial attention within the family of exploration behaviors. PMID:22633805

  5. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: Modelling the clustering and halo occupation distribution of BOSS CMASS galaxies in the Final Data Release

    NASA Astrophysics Data System (ADS)

    Rodríguez-Torres, Sergio A.; Chuang, Chia-Hsun; Prada, Francisco; Guo, Hong; Klypin, Anatoly; Behroozi, Peter; Hahn, Chang Hoon; Comparat, Johan; Yepes, Gustavo; Montero-Dorta, Antonio D.; Brownstein, Joel R.; Maraston, Claudia; McBride, Cameron K.; Tinker, Jeremy; Gottlöber, Stefan; Favole, Ginevra; Shu, Yiping; Kitaura, Francisco-Shu; Bolton, Adam; Scoccimarro, Román; Samushia, Lado; Schlegel, David; Schneider, Donald P.; Thomas, Daniel

    2016-04-01

    We present a study of the clustering and halo occupation distribution of BOSS CMASS galaxies in the redshift range 0.43 < z < 0.7 drawn from the Final SDSS-III Data Release. We compare the BOSS results with the predictions of a Halo Abundance Matching (HAM) clustering model that assigns galaxies to dark matter halos selected from the large BIGMULTIDARK N-body simulation of a flat ΛCDM Planck cosmology. We compare the observational data with the simulated ones on a light-cone constructed from 20 subsequent outputs of the simulation. Observational effects such as incompleteness, geometry, veto masks and fiber collisions are included in the model, which reproduces within 1-σ errors the observed monopole of the 2-point correlation function at all relevant scales: from the smallest scales, 0.5 h-1 Mpc, up to scales beyond the Baryonic Acoustic Oscillation feature. This model also agrees remarkably well with the BOSS galaxy power spectrum (up to k ˜ 1 h Mpc-1), and the Three-point correlation function. The quadrupole of the correlation function presents some tensions with observations. We discuss possible causes that can explain this disagreement, including target selection effects. Overall, the standard HAM model describes remarkably well the clustering statistics of the CMASS sample. We compare the stellar to halo mass relation for the CMASS sample measured using weak lensing in the CFHT Stripe 82 Survey with the prediction of our clustering model, and find a good agreement within 1-σ. The BIGMD-BOSS light-cone including properties of BOSS galaxies and halo properties is made publicly available.

  6. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: modelling the clustering and halo occupation distribution of BOSS CMASS galaxies in the Final Data Release

    NASA Astrophysics Data System (ADS)

    Rodríguez-Torres, Sergio A.; Chuang, Chia-Hsun; Prada, Francisco; Guo, Hong; Klypin, Anatoly; Behroozi, Peter; Hahn, Chang Hoon; Comparat, Johan; Yepes, Gustavo; Montero-Dorta, Antonio D.; Brownstein, Joel R.; Maraston, Claudia; McBride, Cameron K.; Tinker, Jeremy; Gottlöber, Stefan; Favole, Ginevra; Shu, Yiping; Kitaura, Francisco-Shu; Bolton, Adam; Scoccimarro, Román; Samushia, Lado; Schlegel, David; Schneider, Donald P.; Thomas, Daniel

    2016-08-01

    We present a study of the clustering and halo occupation distribution of Baryon Oscillation Spectroscopic Survey (BOSS) CMASS galaxies in the redshift range 0.43 < z < 0.7 drawn from the Final SDSS-III Data Release. We compare the BOSS results with the predictions of a halo abundance matching (HAM) clustering model that assigns galaxies to dark matter haloes selected from the large BigMultiDark N-body simulation of a flat Λ cold dark matter Planck cosmology. We compare the observational data with the simulated ones on a light cone constructed from 20 subsequent outputs of the simulation. Observational effects such as incompleteness, geometry, veto masks and fibre collisions are included in the model, which reproduces within 1σ errors the observed monopole of the two-point correlation function at all relevant scales: from the smallest scales, 0.5 h-1 Mpc, up to scales beyond the baryon acoustic oscillation feature. This model also agrees remarkably well with the BOSS galaxy power spectrum (up to k ˜ 1 h Mpc-1), and the three-point correlation function. The quadrupole of the correlation function presents some tensions with observations. We discuss possible causes that can explain this disagreement, including target selection effects. Overall, the standard HAM model describes remarkably well the clustering statistics of the CMASS sample. We compare the stellar-to-halo mass relation for the CMASS sample measured using weak lensing in the Canada-France-Hawaii Telescope Stripe 82 Survey with the prediction of our clustering model, and find a good agreement within 1σ. The BigMD-BOSS light cone including properties of BOSS galaxies and halo properties is made publicly available.

  7. Cranial Bosses of Choerosaurus dejageri (Therapsida, Therocephalia): Earliest Evidence of Cranial Display Structures in Eutheriodonts

    PubMed Central

    Benoit, Julien; Manger, Paul R.; Fernandez, Vincent; Rubidge, Bruce S.

    2016-01-01

    Choerosaurus dejageri, a non-mammalian eutheriodont therapsid from the South African late Permian (~259 Ma), has conspicuous hemispheric cranial bosses on the maxilla and the mandible. These bosses, the earliest of this nature in a eutheriodont, potentially make C. dejageri a key species for understanding the evolutionary origins of sexually selective behaviours (intraspecific competition, ritualized sexual and intimidation displays) associated with cranial outgrowths at the root of the clade that eventually led to extant mammals. Comparison with the tapinocephalid dinocephalian Moschops capensis, a therapsid in which head butting is strongly supported, shows that the delicate structure of the cranial bosses and the gracile structure of the skull of Choerosaurus would be more suitable for display and low energy combat than vigorous head butting. Thus, despite the fact that Choerosaurus is represented by only one skull (which makes it impossible to address the question of sexual dimorphism), its cranial bosses are better interpreted as structures involved in intraspecific selection, i.e. low-energy fighting or display. Display structures, such as enlarged canines and cranial bosses, are widespread among basal therapsid clades and are also present in the putative basal therapsid Tetraceratops insignis. This suggests that sexual selection may have played a more important role in the distant origin and evolution of mammals earlier than previously thought. Sexual selection may explain the subsequent independent evolution of cranial outgrowths and pachyostosis in different therapsid lineages (Biarmosuchia, Dinocephalia, Gorgonopsia and Dicynodontia). PMID:27548428

  8. Cranial Bosses of Choerosaurus dejageri (Therapsida, Therocephalia): Earliest Evidence of Cranial Display Structures in Eutheriodonts.

    PubMed

    Benoit, Julien; Manger, Paul R; Fernandez, Vincent; Rubidge, Bruce S

    2016-01-01

    Choerosaurus dejageri, a non-mammalian eutheriodont therapsid from the South African late Permian (~259 Ma), has conspicuous hemispheric cranial bosses on the maxilla and the mandible. These bosses, the earliest of this nature in a eutheriodont, potentially make C. dejageri a key species for understanding the evolutionary origins of sexually selective behaviours (intraspecific competition, ritualized sexual and intimidation displays) associated with cranial outgrowths at the root of the clade that eventually led to extant mammals. Comparison with the tapinocephalid dinocephalian Moschops capensis, a therapsid in which head butting is strongly supported, shows that the delicate structure of the cranial bosses and the gracile structure of the skull of Choerosaurus would be more suitable for display and low energy combat than vigorous head butting. Thus, despite the fact that Choerosaurus is represented by only one skull (which makes it impossible to address the question of sexual dimorphism), its cranial bosses are better interpreted as structures involved in intraspecific selection, i.e. low-energy fighting or display. Display structures, such as enlarged canines and cranial bosses, are widespread among basal therapsid clades and are also present in the putative basal therapsid Tetraceratops insignis. This suggests that sexual selection may have played a more important role in the distant origin and evolution of mammals earlier than previously thought. Sexual selection may explain the subsequent independent evolution of cranial outgrowths and pachyostosis in different therapsid lineages (Biarmosuchia, Dinocephalia, Gorgonopsia and Dicynodontia). PMID:27548428

  9. Intrinsic alignments of SDSS-III BOSS LOWZ sample galaxies

    NASA Astrophysics Data System (ADS)

    Singh, Sukhdeep; Mandelbaum, Rachel; More, Surhud

    2015-06-01

    Intrinsic alignments (IA) of galaxies, i.e. correlations of galaxy shapes with each other (II) or with the density field (gI), are potentially a major astrophysical source of contamination for weak lensing surveys. We present the results of IA measurements of galaxies on 0.1-200 h-1 Mpc scales using the SDSS-III BOSS low-redshift (LOWZ) sample, in the redshift range 0.16 < z < 0.36. We extend the existing IA measurements for spectroscopic luminous red galaxies (LRGs) to lower luminosities, and show that the luminosity dependence of large-scale IA can be well described by a power law. Within the limited redshift and colour range of our sample, we observe no significant redshift or colour dependence of IA. We measure the halo mass of galaxies using galaxy-galaxy lensing, and show that the mass dependence of large-scale IA is also well described by a power law. We detect variations in the scale dependence of IA with mass and luminosity, which underscores the need to use flexible templates in order to remove the IA signal. We also study the environment dependence of IA by splitting the sample into field and group galaxies, which are further split into satellite and central galaxies. We show that group central galaxies are aligned with their haloes at small scales and also are aligned with the tidal fields out to large scales. We also detect the radial alignments of satellite galaxies within groups. These results can be used to construct better IA models for removal of this contaminant to the weak lensing signal.

  10. Meet the New Boss…Same as the Old Boss? Female Supervisors and Subordinate Career Prospects*

    PubMed Central

    Maume, David J.

    2010-01-01

    Whereas prior research has focused on women’s access to managerial authority, an equally important question is the effect on subordinates’ careers when they report to a female boss. One line of thought suggests that female bosses act as change agents by fostering the careers of female subordinates, whereas the cog in the machine perspective suggests that female bosses either willingly or are constrained to promote men’s careers. Using data from the 2002 National Study of the Changing Workforce, analytic models of subordinates’ perceived job-related support from supervisors and advancement prospects were developed. Results were consistent with the cog in the machine perspective in that in contrast to women, men received more job-related support and were more optimistic about their careers when they reported to a female supervisor. Yet, given the paucity of research on this topic, more research (especially longitudinal studies) is needed to fully understand how supervisors affect subordinates’ careers. PMID:21180397

  11. VizieR Online Data Catalog: E-BOSS. II. Catalogue second release (Peri+, 2015)

    NASA Astrophysics Data System (ADS)

    Peri, C. S.; Benaglia, P.; Isequilla, N. L.

    2015-07-01

    E-BOSS first release (r1, Peri et al., 2012A&A...538A.108P) was based on two samples. Group 1 consisted of a set of sources taken from Noriega-Crespo et al. (1997AJ....113..780N) and Group 2 was a list extracted from Tetzlaff et al. (2011MNRAS.410..190T, Cat. J/MNRAS/410/190). To build the present and second E-BOSS release (r2) we used samples extended to other spectral types, sources with no public WISE data at the moment of making E-BOSS r1, bow shocks from the literature, and bow shocks found serendipitously. (5 data files).

  12. The XMM Cluster Survey: The Halo Occupation Number of BOSS galaxies in X-ray clusters

    NASA Astrophysics Data System (ADS)

    Mehrtens, Nicola; Romer, A. Kathy; Nichol, Robert C.; Collins, Chris A.; Sahlén, Martin; Rooney, Philip J.; Mayers, Julian A.; Bermeo-Hernandez, A.; Bristow, Martyn; Capozzi, Diego; Christodoulou, L.; Comparat, Johan; Hilton, Matt; Hoyle, Ben; Kay, Scott T.; Liddle, Andrew R.; Mann, Robert G.; Masters, Karen; Miller, Christopher J.; Parejko, John K.; Prada, Francisco; Ross, Ashley J.; Schneider, Donald P.; Stott, John P.; Streblyanska, Alina; Viana, Pedro T. P.; White, Martin; Wilcox, Harry; Zehavi, Idit

    2016-08-01

    We present a direct measurement of the mean halo occupation distribution (HOD) of galaxies taken from the eleventh data release (DR11) of the Sloan Digital Sky Survey-III Baryon Acoustic Oscillation Survey (BOSS). The HOD of BOSS low-redshift (LOWZ: 0.2 < z < 0.4) and Constant-Mass (CMASS: 0.43 < z < 0.7) galaxies is inferred via their association with the dark-matter halos of 174 X-ray-selected galaxy clusters drawn from the XMM Cluster Survey (XCS). Halo masses are determined for each galaxy cluster based on X-ray temperature measurements, and range between log10(M180/M⊙) = 13 - 15. Our directly-measured HODs are consistent with the HOD-model fits inferred via the galaxy-clustering analyses of Parejko et al. (2013) for the BOSS LOWZ sample and White et al. (2011) for the BOSS CMASS sample. Under the simplifying assumption that the other parameters that describe the HOD hold the values measured by these authors, we have determined a best-fit alpha-index of 0.91±0.08 and 1.27^{+0.03}_{-0.04} for the CMASS and LOWZ HOD, respectively. These alpha-index values are consistent with those measured by White et al. (2011) and Parejko et al. (2013). In summary, our study provides independent support for the HOD-models assumed during the development of the BOSS mock-galaxy catalogues that have subsequently been used to derive BOSS cosmological constraints.

  13. Parametric study of propeller boss cap fins for container ships

    NASA Astrophysics Data System (ADS)

    Lim, Sang-Seop; Kim, Tae-Won; Lee, Dong-Myung; Kang, Chung-Gil; Kim, Soo-Young

    2014-06-01

    The global price of oil, which is both finite and limited in quantity, has been rising steadily because of the increasing requirements for energy in both developing and developed countries. Furthermore, regulations have been strengthened across all industries to address global warming. Many studies of hull resistance, propulsion and operation of ships have been performed to reduce fuel consumption and emissions. This study examined the design parameters of the propeller boss cap fin (PBCF) and hub cap for 6,000TEU container ships to improve the propulsion efficiency. The design parameters of PBCF have been selected based on the geometrical shape. Computational fluid dynamics (CFD) analysis with a propeller open water (POW) test was performed to check the validity of CFD analysis. The design of experiment (DOE) case was selected as a full factorial design, and the experiment was analyzed by POW and CFD analysis. Analysis of variance (ANOVA) was performed to determine the correlation among design parameters. Four design alternatives of PBCF were selected from the DOE. The shape of a propeller hub cap was selected as a divergent shape, and the divergent angle was determined by the DOE. Four design alternatives of PBCF were attached to the divergent hub cap, and the POW was estimated by CFD. As a result, the divergent hub cap with PBCF has a negative effect on the POW, which is induced by an increase in torque coefficient. A POW test and cavitation test were performed with a divergent hub cap with PBCF to verify the CFD result. The POW test result showed that the open water efficiency was increased approximately 2% with a divergent hub cap compared to a normal cap. The POW test result was similar to the CFD result, and the divergent hub cap with the PBCF models showed lower open water efficiency. This was attributed to an increase in the torque coefficient just like the CFD results. A cavitation test was performed using the 2 models selected. The test result showed

  14. The large-scale quasar-Lyman α forest cross-correlation from BOSS

    SciTech Connect

    Font-Ribera, Andreu; Arnau, Eduard; Miralda-Escudé, Jordi E-mail: edu.arnau.lazaro@gmail.com; and others

    2013-05-01

    We measure the large-scale cross-correlation of quasars with the Lyα forest absorption in redshift space, using ∼ 60000 quasar spectra from Data Release 9 (DR9) of the Baryon Oscillation Spectroscopic Survey (BOSS). The cross-correlation is detected over a wide range of scales, up to comoving separations r of 80 h{sup −1}Mpc. For r > 15 h{sup −1}Mpc, we show that the cross-correlation is well fitted by the linear theory prediction for the mean overdensity around a quasar host halo in the standard ΛCDM model, with the redshift distortions indicative of gravitational evolution detected at high confidence. Using previous determinations of the Lyα forest bias factor obtained from the Lyα autocorrelation, we infer the quasar bias factor to be b{sub q} = 3.64{sup +0.13}{sub −0.15} at a mean redshift z = 2.38, in agreement with previous measurements from the quasar auto-correlation. We also obtain a new estimate of the Lyα forest redshift distortion factor, β{sub F} = 1.1±0.15, slightly larger than but consistent with the previous measurement from the Lyα forest autocorrelation. The simple linear model we use fails at separations r < 15h{sup −1}Mpc, and we show that this may reasonably be due to the enhanced ionization due to radiation from the quasars. We also provide the expected correction that the mass overdensity around the quasar implies for measurements of the ionizing radiation background from the line-of-sight proximity effect.

  15. Measurement of baryon acoustic oscillations in the Lyman-α forest fluctuations in BOSS data release 9

    SciTech Connect

    Slosar, Anže; Iršič, Vid; Kirkby, David; Blomqvist, Michael; Bailey, Stephen; Carithers, Bill; Busca, Nicolás G.; Aubourg, Éric; Bautista, Julian E.; Bhardwaj, Vaishali; Bolton, Adam S.; Brownstein, Joel; Dawson, Kyle S.; Bovy, Jo; Croft, Rupert A.C.; Ho, Shirley; Font-Ribera, Andreu; and others

    2013-04-01

    We use the Baryon Oscillation Spectroscopic Survey (BOSS) Data Release 9 (DR9) to detect and measure the position of the Baryonic Acoustic Oscillation (BAO) feature in the three-dimensional correlation function in the Lyman-α flux fluctuations at a redshift z{sub eff} = 2.4. The feature is clearly detected at significance between 3 and 5 sigma (depending on the broadband model and method of error covariance matrix estimation) and is consistent with predictions of the standard ΛCDM model. We assess the biases in our method, stability of the error covariance matrix and possible systematic effects. We fit the resulting correlation function with several models that decouple the broadband and acoustic scale information. For an isotropic dilation factor, we measure 100 × (α{sub iso} − 1) = −1.6{sup +2.0+4.3+7.4}{sub −2.0−4.1−6.8} (stat.) ±1.0 (syst.) (multiple statistical errors denote 1,2 and 3 sigma confidence limits) with respect to the acoustic scale in the fiducial cosmological model (flat ΛCDM with Ω{sub m} = 0.27, h = 0.7). When fitting separately for the radial and transversal dilation factors we find marginalised constraints 100 × (α{sub ||} − 1) = −1.3{sup +3.5+7.6+12.3}{sub −3.3−6.7−10.2} (stat.) ±2.0 (syst.) and 100 × (α{sub p}erpendicular − 1) = −2.2{sup +7.4+17}{sub −7.1−15} (stat.) ±3.0 (syst.). The dilation factor measurements are significantly correlated with cross-correlation coefficient of ∼ −0.55. Errors become significantly non-Gaussian for deviations over 3 standard deviations from best fit value. Because of the data cuts and analysis method, these measurements give tighter constraints than a previous BAO analysis of the BOSS DR9 Lyman-α sample, providing an important consistency test of the standard cosmological model in a new redshift regime.

  16. The MICRO-BOSS scheduling system: Current status and future efforts

    NASA Technical Reports Server (NTRS)

    Sadeh, Norman M.

    1993-01-01

    In this paper, a micro-opportunistic approach to factory scheduling was described that closely monitors the evolution of bottlenecks during the construction of the schedule, and continuously redirects search towards the bottleneck that appears to be most critical. This approach differs from earlier opportunistic approaches, as it does not require scheduling large resource subproblems or large job subproblems before revising the current scheduling strategy. This micro-opportunistic approach was implemented in the context of the MICRO-BOSS factory scheduling system. A study comparing MICRO-BOSS against a macro-opportunistic scheduler suggests that the additional flexibility of the micro-opportunistic approach to scheduling generally yields important reductions in both tardiness and inventory.

  17. Headphone localization of speech stimuli

    NASA Technical Reports Server (NTRS)

    Begault, Durand R.; Wenzel, Elizabeth M.

    1991-01-01

    Recently, three dimensional acoustic display systems have been developed that synthesize virtual sound sources over headphones based on filtering by Head-Related Transfer Functions (HRTFs), the direction-dependent spectral changes caused primarily by the outer ears. Here, 11 inexperienced subjects judged the apparent spatial location of headphone-presented speech stimuli filtered with non-individualized HRTFs. About half of the subjects 'pulled' their judgements toward either the median or the lateral-vertical planes, and estimates were almost always elevated. Individual differences were pronounced for the distance judgements; 15 to 46 percent of stimuli were heard inside the head with the shortest estimates near the median plane. The results infer that most listeners can obtain useful azimuth information from speech stimuli filtered by nonindividualized RTFs. Measurements of localization error and reversal rates are comparable with a previous study that used broadband noise stimuli.

  18. In an Era of Reform: Standards and the Classroom.

    ERIC Educational Resources Information Center

    Weeks, Denise Jarrett, Ed.; Stepanek, Jennifer, Ed.

    2001-01-01

    This Northwest Teacher is a journal that is devoted to rigorous and imaginative learning. In the Winter 2001 issue, articles include: (1) "Standards and the Impulse for Human Betterment" (Denise Jarrett Weeks); (2) "Teachers Taking Charge of Change" (Suzie Boss); (3) "Using the Standards To Illuminate Big Ideas in Science" (Jennifer Stepanek); (4)…

  19. Plasma Sprayed Bondable Stainless Surface (BOSS) Coatings for Corrosion Protection and Adhesion Treatments

    NASA Technical Reports Server (NTRS)

    Davis, G. D.; Groff, G. B.; Rooney, M.; Cooke, A. V.; Boothe, R.

    1995-01-01

    Plasma-sprayed Bondable Stainless Surface (BOSS) coatings are being developed under the Solid Propulsion Integrity Program's (SPIP) Bondlines Package. These coatings are designed as a steel case preparation treatment prior to insulation lay-up. Other uses include the exterior of steel cases and bonding surfaces of nozzle components. They provide excellent bondability - rubber insulation and epoxy bonds fail cohesively within the polymer - for both fresh surfaces and surfaces having undergone natural and accelerated environmental aging. They have passed the MSFC requirements for protection of inland and sea coast environment. Because BOSS coatings are inherently corrosion resistant, they do not require preservation by greases or oils. The reduction/elimination of greases and oils, known bondline degraders, can increase SRM reliability, decrease costs by reducing the number of process steps, and decrease environmental pollution by reducing the amount of methyl chloroform used for degreasing and thus reduce release of the ozone-depleting chemical in accordance with the Clean Air Act and the Montreal Protocol. The coatings can potential extend the life of RSRM case segments and nozzle components by eliminating erosion due to multiple grit blasting during each use cycle and corrosion damage during marine recovery. Concurrent work for the Air Force show that other BOSS coatings give excellent bondline strength and durability for high-performance structures of aluminum and titanium.

  20. The MICRO-BOSS scheduling system: Current status and future efforts

    NASA Technical Reports Server (NTRS)

    Sadeh, Norman M.

    1992-01-01

    In this paper, a micro-opportunistic approach to factory scheduling was described that closely monitors the evolution of bottlenecks during the construction of the schedule and continuously redirects search towards the bottleneck that appears to be most critical. This approach differs from earlier opportunistic approaches, as it does not require scheduling large resource subproblems or large job subproblems before revising the current scheduling strategy. This micro-opportunistic approach was implemented in the context of the MICRO-BOSS factory scheduling system. A study comparing MICRO-BOSS against a macro-opportunistic scheduler suggests that the additional flexibility of the micro-opportunistic approach to scheduling generally yields important reductions in both tardiness and inventory. Current research efforts include: adaptation of MICRO-BOSS to deal with sequence-dependent setups and development of micro-opportunistic reactive scheduling techniques that will enable the system to patch the schedule in the presence of contingencies such as machine breakdowns, raw materials arriving late, job cancellations, etc.

  1. Super-size me: self biases increase to larger stimuli.

    PubMed

    Sui, Jie; Humphreys, Glyn W

    2015-04-01

    Prior work has shown that simple perceptual match responses to pairings of shapes and labels are more efficient if the pairing is associated with the participant (e.g., circle-you) than if it is associated with another familiar person (e.g., square-friend). There is a similar advantage for matching associations with high-value rewards (circle-£9) versus low-value rewards (square-£1) (Sui, He, & Humphreys Journal of Experimental Psychology: Human Perception and Performance, 38, 1105-1117, 2012). Here we evaluated the relations between the self- and reward-bias effects by introducing occasional trials in which the size of a shape was varied unexpectedly (large or small vs. a standard medium). Participants favored stimuli that were larger than the standard when stimuli were associated with the self, and this enhancement of self bias was predicted by the degree of self bias that participants showed to standard (medium) sized stimuli. Although we observed a correlation between the magnitudes of the self and reward biases over participants, reward-bias effects were not increased to large stimuli. The data suggest both overlapping and independent components of the self and reward biases, and that self biases are uniquely enhanced when stimuli increase in size, consistent with previously reported motivational biases favoring large stimuli. PMID:25112393

  2. Neural Processing of Emotional Musical and Nonmusical Stimuli in Depression

    PubMed Central

    Atchley, Ruth Ann; Chrysikou, Evangelia; Martin, Laura E.; Clair, Alicia A.; Ingram, Rick E.; Simmons, W. Kyle; Savage, Cary R.

    2016-01-01

    Background Anterior cingulate cortex (ACC) and striatum are part of the emotional neural circuitry implicated in major depressive disorder (MDD). Music is often used for emotion regulation, and pleasurable music listening activates the dopaminergic system in the brain, including the ACC. The present study uses functional MRI (fMRI) and an emotional nonmusical and musical stimuli paradigm to examine how neural processing of emotionally provocative auditory stimuli is altered within the ACC and striatum in depression. Method Nineteen MDD and 20 never-depressed (ND) control participants listened to standardized positive and negative emotional musical and nonmusical stimuli during fMRI scanning and gave subjective ratings of valence and arousal following scanning. Results ND participants exhibited greater activation to positive versus negative stimuli in ventral ACC. When compared with ND participants, MDD participants showed a different pattern of activation in ACC. In the rostral part of the ACC, ND participants showed greater activation for positive information, while MDD participants showed greater activation to negative information. In dorsal ACC, the pattern of activation distinguished between the types of stimuli, with ND participants showing greater activation to music compared to nonmusical stimuli, while MDD participants showed greater activation to nonmusical stimuli, with the greatest response to negative nonmusical stimuli. No group differences were found in striatum. Conclusions These results suggest that people with depression may process emotional auditory stimuli differently based on both the type of stimulation and the emotional content of that stimulation. This raises the possibility that music may be useful in retraining ACC function, potentially leading to more effective and targeted treatments. PMID:27284693

  3. Stimuli, Reinforcers, and Private Events

    ERIC Educational Resources Information Center

    Nevin, John A.

    2008-01-01

    Radical behaviorism considers private events to be a part of ongoing observable behavior and to share the properties of public events. Although private events cannot be measured directly, their roles in overt action can be inferred from mathematical models that relate private responses to external stimuli and reinforcers according to the same…

  4. CLUSTER LENSING PROFILES DERIVED FROM A REDSHIFT ENHANCEMENT OF MAGNIFIED BOSS-SURVEY GALAXIES

    SciTech Connect

    Coupon, Jean; Umetsu, Keiichi; Broadhurst, Tom

    2013-07-20

    We report the first detection of a redshift-depth enhancement of background galaxies magnified by foreground clusters. Using 300,000 BOSS survey galaxies with accurate spectroscopic redshifts, we measure their mean redshift depth behind four large samples of optically selected clusters from the Sloan Digital Sky Survey (SDSS) surveys, totaling 5000-15,000 clusters. A clear trend of increasing mean redshift toward the cluster centers is found, averaged over each of the four cluster samples. In addition, we find similar but noisier behavior for an independent X-ray sample of 158 clusters lying in the foreground of the current BOSS sky area. By adopting the mass-richness relationships appropriate for each survey, we compare our results with theoretical predictions for each of the four SDSS cluster catalogs. The radial form of this redshift enhancement is well fitted by a richness-to-mass weighted composite Navarro-Frenk-White profile with an effective mass ranging between M{sub 200} {approx} 1.4-1.8 Multiplication-Sign 10{sup 14} M{sub Sun} for the optically detected cluster samples, and M{sub 200} {approx} 5.0 Multiplication-Sign 10{sup 14} M{sub Sun} for the X-ray sample. This lensing detection helps to establish the credibility of these SDSS cluster surveys, and provides a normalization for their respective mass-richness relations. In the context of the upcoming bigBOSS, Subaru Prime Focus Spectrograph, and EUCLID-NISP spectroscopic surveys, this method represents an independent means of deriving the masses of cluster samples for examining the cosmological evolution, and provides a relatively clean consistency check of weak-lensing measurements, free from the systematic limitations of shear calibration.

  5. SDSS-IV: The Clustering of eBOSS LRGs using photometric redshifts

    NASA Astrophysics Data System (ADS)

    Prakash, Abhishek; SDSS-IV/eBOSS

    2016-01-01

    SDSS-IV/eBOSS is producing an exciting data set for cosmology which will add to our understanding of the large-scale structure of the Universe. The Luminous Red Galaxy (LRG) component of this survey will cover a redshift regime barely explored by SDSS-III/BOSS and will allow a ˜1% measurement of the Baryon Acoustic Oscillation (BAO) scale and a 4.0% Redshift Space Distortion (RSD) measurement using a relatively uniform set of luminous, early-type galaxies in the redshift range 0.6 < z < 1. We briefly review a new technique of selecting high-z LRGs utilizing SDSS and WISE (infrared) photometry in combination. These galaxies are old, elliptical systems with strong 4000 °A breaks. Old stellar populations exhibit a global maximum in their spectral energy distributions (SEDs) at a wavelength of 1.6 μm, commonly referred to as the '1.6 μm bump'. Since LRGs possess very few young stars, this feature generally dominates their overall SEDs which makes them extremely bright in infrared. SDSS-IV/eBOSS LRGs range from redshift z = 0.6 to 1.0 over 10,000 square degrees of the sky. Here we briefly present the results of the 3D real space clustering power spectrum of a sample of 600,000 luminous red galaxies (LRGs) measured by the Sloan Digital Sky Survey (SDSS), using photometric redshifts. Although spectroscopic redshifts provide stronger constraints on large scale measurements, these results demonstrate the ability to make precise clustering measurements with photometric surveys.

  6. Estimating the angular power spectrum of z > 2 BOSS QSOs using the MASTER method

    NASA Astrophysics Data System (ADS)

    Maldonado, Felipe; Huffenberger, Kevin; Rotti, Aditya

    2016-01-01

    We implement the MASTER method for angular power spectrum estimation and apply it to z > 2 quasars selected by the SDSS-III BOSS survey. Quasars are filtered for completeness and bad spectra, and include ~100,000 QSOs in the CORE sample and ~75,000 in the non-uniform BONUS sample. We estimate the angular power spectrum in redshift shells to constrain the matter power spectrum and quasar properties. In the future, we will jointly analyze overlapping Cosmic Microwave Background lensing maps from the Atacama Cosmology Telescope to place further constraints.

  7. Consistency of the nonflat Λ CDM model with the new result from BOSS

    NASA Astrophysics Data System (ADS)

    Kumar, Suresh

    2015-11-01

    Using 137,562 quasars in the redshift range 2.1 ≤z ≤3.5 from the data release 11 (DR11) of the baryon oscillation spectroscopic survey (BOSS) of Sloan Digital Sky Survey (SDSS)-III, the BOSS-SDSS collaboration estimated the expansion rate H (z =2.34 )=222 ±7 km /s /Mpc of the Universe, and reported that this value is in tension with the predictions of flat Λ CDM model at around a 2.5 σ level. In this paper, we briefly describe some attempts made in the literature to relieve the tension, and show that the tension can naturally be alleviated in a nonflat Λ CDM model with positive curvature. We also perform the observational consistency check by considering the constraints on the nonflat Λ CDM model from Planck, WP and BAO data. We find that the nonflat Λ CDM model constrained with Planck+WP data fits better to the line of sight measurement H (z =2.34 )=222 ±7 km /s /Mpc , but only at the expense of still having a poor fit to the BAO transverse measurements.

  8. Numerical study on the influence of boss cap fins on efficiency of controllable-pitch propeller

    NASA Astrophysics Data System (ADS)

    Xiong, Ying; Wang, Zhanzhi; Qi, Wanjiang

    2013-03-01

    Numerical simulation is investigated to disclose how propeller boss cap fins (PBCF) operate utilizing Reynolds-averaged Navier-Stokes (RANS) method. In addition, exploration of the influencing mechanism of PBCF on the open water efficiency of one controllable-pitch propeller is analyzed through the open water characteristic curves, blade surface pressure distribution and hub streamline distribution. On this basis, the influence of parameters including airfoil profile, diameter, axial position of installation and circumferential installation angle on the open water efficiency of the controllable-pitch propeller is investigated. Numerical results show: for the controllable-pitch propeller, the thrust generated is at the optimum when the radius of boss cap fins is 1.5 times of propeller hub with an optimal installation position in the axial direction, and its optimal circumferential installation position is the midpoint of the extension line of the front and back ends of two adjacent propeller roots in the front of fin root. Under these optimal parameters, the gain of open water efficiency of the controllable-pitch propeller with different advance velocity coefficients is greater than 0.01, which accounts for approximately an increase of 1%-5% of open water efficiency.

  9. The Composite Spectrum of BOSS Quasars Selected for Studies of the Lyα Forest

    NASA Astrophysics Data System (ADS)

    Harris, David W.; Jensen, Trey W.; Suzuki, Nao; Bautista, Julian E.; Dawson, Kyle S.; Vivek, M.; Brownstein, Joel R.; Ge, Jian; Hamann, Fred; Herbst, H.; Jiang, Linhua; Moran, Sarah E.; Myers, Adam D.; Olmstead, Matthew D.; Schneider, Donald P.

    2016-06-01

    The Baryon Oscillation Spectroscopic Survey (BOSS) has collected more than 150,000 2.1 ≤ z ≤ 3.5 quasar spectra since 2009. Using this unprecedented sample, we create a composite spectrum in the rest-frame of 102,150 quasar spectra from 800–3300 Å at a signal-to-noise ratio close to 1000 per pixel (Δv of 69 km s‑1). Included in this analysis is a correction to account for flux calibration residuals in the BOSS spectrophotometry. We determine the spectral index as a function of redshift of the full sample, warp the composite spectrum to match the median spectral index, and compare the resulting spectrum to Sloan Digital Sky Survey (SDSS) photometry used in target selection. The quasar composite matches the color of the quasar population to 0.02 mag in g ‑ r, 0.03 mag in r ‑ i, and 0.01 mag in i ‑ z over the redshift range 2.2 < z < 2.6. The composite spectrum deviates from the imaging photometry by 0.05 mag around z = 2.7, likely due to differences in target selection as the quasar colors become similar to the stellar locus at this redshift. Finally, we characterize the line features in the high signal-to-noise composite and identify nine faint lines not found in the previous composite spectrum from SDSS.

  10. Mimicking biophysical stimuli within bone tumor microenvironment*

    PubMed Central

    Marturano-Kruik, A.; Yeager, K.; Bach, D.; Villasante, A.; Cimetta, E.; Vunjak-Novakovic, G.

    2016-01-01

    In vivo, cells reside in a complex environment regulating their fate and function. Most of this complexity is lacking in standard in vitro models, leading to readouts falling short of predicting the actual in vivo situation. The use of engineering tools, combined with deep biological knowledge, leads to the development and use of bioreactors providing biologically sound niches. Such bioreactors offer new tools for biological research, and are now also entering the field of cancer research. Here we present the development and validation of a modular bioreactor system providing: (i) high throughput analyses, (ii) a range of biological conditions, (iii) high degree of control, and (iv) application of physiological stimuli to the cultured samples. The bioreactor was used to engineer a three-dimensional (3D) tissue model of cancer, where the effects of mechanical stimulation on the tumor phenotype were evaluated. Mechanical stimuli applied to the engineered tumor model activated the mechanotransduction machinery and resulted in measurable changes of mRNA levels towards a more aggressive tumor phenotype. PMID:26737062

  11. Emotional Stimuli and Motor Conversion Disorder

    ERIC Educational Resources Information Center

    Voon, Valerie; Brezing, Christina; Gallea, Cecile; Ameli, Rezvan; Roelofs, Karin; LaFrance, W. Curt, Jr.; Hallett, Mark

    2010-01-01

    Conversion disorder is characterized by neurological signs and symptoms related to an underlying psychological issue. Amygdala activity to affective stimuli is well characterized in healthy volunteers with greater amygdala activity to both negative and positive stimuli relative to neutral stimuli, and greater activity to negative relative to…

  12. Application of a BOSS-Gaussian interface for QM/MM simulations of Henry and methyl transfer reactions.

    PubMed

    Vilseck, Jonah Z; Kostal, Jakub; Tirado-Rives, Julian; Jorgensen, William L

    2015-10-15

    Hybrid quantum mechanics and molecular mechanics (QM/MM) computer simulations have become an indispensable tool for studying chemical and biological phenomena for systems too large to treat with QM alone. For several decades, semiempirical QM methods have been used in QM/MM simulations. However, with increased computational resources, the introduction of ab initio and density function methods into on-the-fly QM/MM simulations is being increasingly preferred. This adaptation can be accomplished with a program interface that tethers independent QM and MM software packages. This report introduces such an interface for the BOSS and Gaussian programs, featuring modification of BOSS to request QM energies and partial atomic charges from Gaussian. A customizable C-shell linker script facilitates the interprogram communication. The BOSS-Gaussian interface also provides convenient access to Charge Model 5 (CM5) partial atomic charges for multiple purposes including QM/MM studies of reactions. In this report, the BOSS-Gaussian interface is applied to a nitroaldol (Henry) reaction and two methyl transfer reactions in aqueous solution. Improved agreement with experiment is found by determining free-energy surfaces with MP2/CM5 QM/MM simulations than previously reported investigations using semiempirical methods. PMID:26311531

  13. Enhanced brain susceptibility to negative stimuli in adolescents: ERP evidences

    PubMed Central

    Yuan, Jiajin; Ju, Enxia; Meng, Xianxin; Chen, Xuhai; Zhu, Siyu; Yang, Jiemin; Li, Hong

    2015-01-01

    Background: Previous studies investigated neural substrates of emotional face processing in adolescents and its comparison with adults. As emotional faces elicit more of emotional expression recognition rather than direct emotional responding, it remains undetermined how adolescents are different from adults in brain susceptibility to emotionally stressful stimuli. Methods: Event-Related Potentials (ERPs) were recorded for highly negative (HN), moderately negative (MN), and neutral pictures in 20 adolescents and 20 adults while subjects performed a standard/deviant distinction task by pressing different keys, irrespective of the emotionality of deviant stimuli. Results: Adolescents exhibited more negative amplitudes for HN vs. neutral pictures in N1 (100–150 ms), P2 (130–190 ms), N2 (210–290 ms), and P3 (360–440 ms) components. In addition, adolescents showed more negative amplitudes for MN compared to neutral pictures in N1, P2, and N2 components. By contrast, adults exhibited significant emotion effects for HN stimuli in N2 and P3 amplitudes but not in N1 and P2 amplitudes, and they did not exhibit a significant emotion effect for MN stimuli at all these components. In the 210–290 ms time interval, the emotion effect for HN stimuli was significant across frontal and central regions in adolescents, while this emotion effect was noticeable only in the central region for adults. Conclusions: Adolescents are more emotionally sensitive to negative stimuli compared to adults, regardless of the emotional intensity of the stimuli, possibly due to the immature prefrontal control system over the limbic emotional inputs during adolescence. PMID:25972790

  14. The Role of Active Exploration of 3D Face Stimuli on Recognition Memory of Facial Information

    ERIC Educational Resources Information Center

    Liu, Chang Hong; Ward, James; Markall, Helena

    2007-01-01

    Research on face recognition has mainly relied on methods in which observers are relatively passive viewers of face stimuli. This study investigated whether active exploration of three-dimensional (3D) face stimuli could facilitate recognition memory. A standard recognition task and a sequential matching task were employed in a yoked design.…

  15. Lya intensity mapping: current observational results from SDSS/BOSS and its future potential.

    NASA Astrophysics Data System (ADS)

    Croft, Rupert A.; Miralda-Escudé, Jordi; Zheng, Zheng

    2016-01-01

    Over the past 10 years, widefield optical survey telescopes have taken several million fiber spectra of objects in the night sky. This enormous dataset can be used to carry out optical intensity mapping measurements right now, as well as informing and motivating future dedicated instruments. Using cross-correlation techniques have made measurements of the large-scale structure of the Universe in the hydrogen Lyman-alpha line from SDSS/BOSS fiber spectra. We compare our results to the structure expected in the LambdaCDM cosmological model, and make the first global estimate of the Lyman-alpha luminosity density of the Universe. We discuss how lessons learned during our analysis can be applied to future experiments, and which observational tracers will be useful for further applications of these techniques. We also show how intensity mapping could dramatically enhance our ability to make measurements of new effects in galaxy clustering, such as general and special relativistic distortions.

  16. BigBOSS: The Ground-Based Stage IV BAO Experiment

    SciTech Connect

    Schlegel, David; Bebek, Chris; Heetderks, Henry; Ho, Shirley; Lampton, Michael; Levi, Michael; Mostek, Nick; Padmanabhan, Nikhil; Perlmutter, Saul; Roe, Natalie; Sholl, Michael; Smoot, George; White, Martin; Dey, Arjun; Abraham, Tony; Jannuzi, Buell; Joyce, Dick; Liang, Ming; Merrill, Mike; Olsen, Knut; Salim, Samir

    2009-04-01

    The BigBOSS experiment is a proposed DOE-NSF Stage IV ground-based dark energy experiment to study baryon acoustic oscillations (BAO) and the growth of structure with an all-sky galaxy redshift survey. The project is designed to unlock the mystery of dark energy using existing ground-based facilities operated by NOAO. A new 4000-fiber R=5000 spectrograph covering a 3-degree diameter field will measure BAO and redshift space distortions in the distribution of galaxies and hydrogen gas spanning redshifts from 0.2< z< 3.5. The Dark Energy Task Force figure of merit (DETF FoM) for this experiment is expected to be equal to that of a JDEM mission for BAO with the lower risk and cost typical of a ground-based experiment.

  17. The experiment BOSS on EXPOSE R-2, Mission Preparation Tests for Biofilm Organisms Surfing Space

    NASA Astrophysics Data System (ADS)

    Panitz, C.; Rettberg, P.; Rabbow, E.; Bauermeister, A.; Barczyk, S.; Billi, D.; Cockell, Ch.; Flemming, H. C.; Stan-Lotter, H.; Venkateswaran, K.

    2012-09-01

    In the experiment BOSS the hypothesis will be tested if the biofilm form of life with microorganisms embedded and aggregated in their EPS matrix is suited to support long-term survival of microorganisms under the harsh environmental conditions as they exist in space and on Mars and is superior to the same bacteria in the form of planktonic cultures. An additional protective role may be provided by particles associated in biofilms which may shield the organisms against radiation. The experiment will be flown on EXPOSE R-2 attached outside of the ISS on the Russian module. The experiment has participated at the Experiment verification tests and a Science verification test which have been carried out in the Planetary and Space Simulation Facilities at DLR. The launch is scheduled for end of 2013.

  18. Spectral Evolution in High Redshift Quasars from the Final BOSS Sample

    NASA Astrophysics Data System (ADS)

    Jensen, Trey; Bautista, Julian; Dawson, Kyle; Harris, David; Kamble, Vikrant; Mariappan, Vivek; Suzuki, Nao

    2016-01-01

    We report on a study of the spectral variations in a sample of 102,150 quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) of the Sloan Digital Sky Survey (SDSS-III). After mitigating selection effects and Malmquist bias over the redshift range 2.1 ≤ z ≤ 3.5, we create high signal-to-noise composite spectra binned by luminosity, spectral index, and redshift. We use these composite spectra to inspect the variations in quasar properties as a function of each of these three parameters. We confirm the traditional Baldwin effect (i.e. the anti-correlation of CIV equivalent width and luminosity) and identify physical trends associated with spectral index and redshift. In this poster, we will present these results with a particular focus on the clear spectroscopic signature that we find in redshift evolution.

  19. Redshift evolution of the dynamical properties of massive galaxies from SDSS-III/BOSS

    SciTech Connect

    Beifiori, Alessandra; Saglia, Roberto P.; Bender, Ralf; Senger, Robert; Thomas, Daniel; Maraston, Claudia; Steele, Oliver; Masters, Karen L.; Pforr, Janine; Tojeiro, Rita; Johansson, Jonas; Nichol, Robert C.; Chen, Yan-Mei; Wake, David; Bolton, Adam; Brownstein, Joel R.; Leauthaud, Alexie; Schneider, Donald P.; Skibba, Ramin; Pan, Kaike; and others

    2014-07-10

    We study the redshift evolution of the dynamical properties of ∼180, 000 massive galaxies from SDSS-III/BOSS combined with a local early-type galaxy sample from SDSS-II in the redshift range 0.1 ≤ z ≤ 0.6. The typical stellar mass of this sample is M{sub *} ∼2 × 10{sup 11} M{sub ☉}. We analyze the evolution of the galaxy parameters effective radius, stellar velocity dispersion, and the dynamical to stellar mass ratio with redshift. As the effective radii of BOSS galaxies at these redshifts are not well resolved in the Sloan Digital Sky Survey (SDSS) imaging we calibrate the SDSS size measurements with Hubble Space Telescope/COSMOS photometry for a sub-sample of galaxies. We further apply a correction for progenitor bias to build a sample which consists of a coeval, passively evolving population. Systematic errors due to size correction and the calculation of dynamical mass are assessed through Monte Carlo simulations. At fixed stellar or dynamical mass, we find moderate evolution in galaxy size and stellar velocity dispersion, in agreement with previous studies. We show that this results in a decrease of the dynamical to stellar mass ratio with redshift at >2σ significance. By combining our sample with high-redshift literature data, we find that this evolution of the dynamical to stellar mass ratio continues beyond z ∼ 0.7 up to z > 2 as M{sub dyn}/M{sub *} ∼(1 + z){sup –0.30±0.12}, further strengthening the evidence for an increase of M{sub dyn}/M{sub *} with cosmic time. This result is in line with recent predictions from galaxy formation simulations based on minor merger driven mass growth, in which the dark matter fraction within the half-light radius increases with cosmic time.

  20. The BOSS Lyα Forest Sample from SDSS Data Release 9

    NASA Astrophysics Data System (ADS)

    Lee, Khee-Gan; Bailey, Stephen; Bartsch, Leslie E.; Carithers, William; Dawson, Kyle S.; Kirkby, David; Lundgren, Britt; Margala, Daniel; Palanque-Delabrouille, Nathalie; Pieri, Matthew M.; Schlegel, David J.; Weinberg, David H.; Yèche, Christophe; Aubourg, Éric; Bautista, Julian; Bizyaev, Dmitry; Blomqvist, Michael; Bolton, Adam S.; Borde, Arnaud; Brewington, Howard; Busca, Nicolás G.; Croft, Rupert A. C.; Delubac, Timothée; Ebelke, Garrett; Eisenstein, Daniel J.; Font-Ribera, Andreu; Ge, Jian; Hamilton, Jean-Christophe; Hennawi, Joseph F.; Ho, Shirley; Honscheid, Klaus; Le Goff, Jean-Marc; Malanushenko, Elena; Malanushenko, Viktor; Miralda-Escudé, Jordi; Myers, Adam D.; Noterdaeme, Pasquier; Oravetz, Daniel; Pan, Kaike; Pâris, Isabelle; Petitjean, Patrick; Rich, James; Rollinde, Emmanuel; Ross, Nicholas P.; Rossi, Graziano; Schneider, Donald P.; Simmons, Audrey; Snedden, Stephanie; Slosar, Anže; Spergel, David N.; Suzuki, Nao; Viel, Matteo; Weaver, Benjamin A.

    2013-03-01

    We present the BOSS Lyman-α (Lyα) Forest Sample from SDSS Data Release 9, comprising 54,468 quasar spectra with z qso > 2.15 suitable for Lyα forest analysis. This data set probes the intergalactic medium with absorption redshifts 2.0 < z α < 5.7 over an area of 3275 deg2, and encompasses an approximate comoving volume of 20 h -3 Gpc3. With each spectrum, we have included several products designed to aid in Lyα forest analysis: improved sky masks that flag pixels where data may be unreliable, corrections for known biases in the pipeline estimated noise, masks for the cores of damped Lyα systems and corrections for their wings, and estimates of the unabsorbed continua so that the observed flux can be converted to a fractional transmission. The continua are derived using a principal component fit to the quasar spectrum redward of rest-frame Lyα (λ > 1216 Å), extrapolated into the forest region and normalized by a linear function to fit the expected evolution of the Lyα forest mean flux. The estimated continuum errors are <~ 5% rms. We also discuss possible systematics arising from uncertain spectrophotometry and artifacts in the flux calibration; global corrections for the latter are provided. Our sample provides a convenient starting point for users to analyze clustering in BOSS Lyα forest data, and it provides a fiducial data set that can be used to compare results from different analyses of baryon acoustic oscillations in the Lyα forest. The full data set is available from the SDSS-III DR9 Web site.

  1. Dear white boss. Do you remember that first management-team offsite.

    PubMed

    Caver, Keith A; Livers, Ancella B

    2002-11-01

    It's easy for white managers to assume that their colleagues of color face the same basic challenges they do. On one level that's true--the work itself is the same. But on another level, African-American managers often contend with an atmosphere of tension, instability, and distrust that can be so frustrating they lose the desire to contribute fully. Their white bosses and coworkers are simply unaware of the "miasma" and are often puzzled when African-Americans quit apparently for no reason or seemingly overreact to a minor incident. This portrayal of what it's like to be different in the workplace takes the form of a fictional letter from a black manager to a white boss. The letter, based on interviews and surveys the authors conducted with hundreds of mid- to senior-level African-American managers, is not about the lack of role models or mentors of color or any of the other barriers that limit opportunities for blacks in corporate America. Instead, the letter sheds light on the realities that lurk below the surface for black managers--the feeling that they leave some part of their identities at home and the sometimes subtle and often systemic racial biases that inhibit and alienate African-Americans. "Differences really do matter, although they may matter in ways you probably didn't expect. One of the big ways they matter is that race is always with us," the letter writer observes. "As a friend of mine said recently, 'I don't think a day goes by that I'm not reminded that I'm black.'" The letter may not apply to every leader, black or white, or to every organization, but the issues are more widespread than corporate America cares to acknowledge. It should be required reading for all white executives who don't want talent to slip through their fingers. PMID:12422791

  2. THE BOSS Ly{alpha} FOREST SAMPLE FROM SDSS DATA RELEASE 9

    SciTech Connect

    Lee, Khee-Gan; Bailey, Stephen; Carithers, William; Schlegel, David J.; Bartsch, Leslie E.; Dawson, Kyle S.; Bolton, Adam S.; Kirkby, David; Margala, Daniel; Blomqvist, Michael; Lundgren, Britt; Palanque-Delabrouille, Nathalie; Yeche, Christophe; Borde, Arnaud; Weinberg, David H.; Aubourg, Eric; Bautista, Julian; and others

    2013-03-15

    We present the BOSS Lyman-{alpha} (Ly{alpha}) Forest Sample from SDSS Data Release 9, comprising 54,468 quasar spectra with z{sub qso} > 2.15 suitable for Ly{alpha} forest analysis. This data set probes the intergalactic medium with absorption redshifts 2.0 < z{sub {alpha}} < 5.7 over an area of 3275 deg{sup 2}, and encompasses an approximate comoving volume of 20 h {sup -3} Gpc{sup 3}. With each spectrum, we have included several products designed to aid in Ly{alpha} forest analysis: improved sky masks that flag pixels where data may be unreliable, corrections for known biases in the pipeline estimated noise, masks for the cores of damped Ly{alpha} systems and corrections for their wings, and estimates of the unabsorbed continua so that the observed flux can be converted to a fractional transmission. The continua are derived using a principal component fit to the quasar spectrum redward of rest-frame Ly{alpha} ({lambda} > 1216 A), extrapolated into the forest region and normalized by a linear function to fit the expected evolution of the Ly{alpha} forest mean flux. The estimated continuum errors are {approx}< 5% rms. We also discuss possible systematics arising from uncertain spectrophotometry and artifacts in the flux calibration; global corrections for the latter are provided. Our sample provides a convenient starting point for users to analyze clustering in BOSS Ly{alpha} forest data, and it provides a fiducial data set that can be used to compare results from different analyses of baryon acoustic oscillations in the Ly{alpha} forest. The full data set is available from the SDSS-III DR9 Web site.

  3. Carpal boss in chronic wrist pain and its association with partial osseous coalition and osteoarthritis - A case report with focus on MRI findings

    PubMed Central

    Poh, Feng

    2015-01-01

    The carpal boss is a bony prominence at the dorsal aspect of the 2nd and/or 3rd carpometacarpal joint, which has been linked to various etiologies, including trauma, os styloideum, osteophyte formation, and partial osseous coalition. It may result in symptoms through secondary degeneration, ganglion formation, bursitis, or extensor tendon abnormalities by altered biomechanics of wrist motion. We present a case of symptomatic carpal boss with the finding of a partial osseous coalition at the 2nd carpometacarpal (metacarpal–trapezoid) joint and highlight the magnetic resonance imaging (MRI) findings of carpal boss impingement and secondary osteoarthritis. To the best of our knowledge, there is no report in the literature describing the imaging findings of partial osseous coalition and degenerative osteoarthritis in relation to carpal boss. PMID:26288522

  4. Happiness increases distraction by auditory deviant stimuli.

    PubMed

    Pacheco-Unguetti, Antonia Pilar; Parmentier, Fabrice B R

    2016-08-01

    Rare and unexpected changes (deviants) in an otherwise repeated stream of task-irrelevant auditory distractors (standards) capture attention and impair behavioural performance in an ongoing visual task. Recent evidence indicates that this effect is increased by sadness in a task involving neutral stimuli. We tested the hypothesis that such effect may not be limited to negative emotions but reflect a general depletion of attentional resources by examining whether a positive emotion (happiness) would increase deviance distraction too. Prior to performing an auditory-visual oddball task, happiness or a neutral mood was induced in participants by means of the exposure to music and the recollection of an autobiographical event. Results from the oddball task showed significantly larger deviance distraction following the induction of happiness. Interestingly, the small amount of distraction typically observed on the standard trial following a deviant trial (post-deviance distraction) was not increased by happiness. We speculate that happiness might interfere with the disengagement of attention from the deviant sound back towards the target stimulus (through the depletion of cognitive resources and/or mind wandering) but help subsequent cognitive control to recover from distraction. PMID:26302716

  5. Exposure to virtual social stimuli modulates subjective pain reports

    PubMed Central

    Vigil, Jacob M; Torres, Daniel; Wolff, Alexander; Hughes, Katy

    2014-01-01

    BACKGROUND: Contextual factors, including the gender of researchers, influence experimental and patient pain reports. It is currently not known how social stimuli influence pain percepts, nor which types of sensory modalities of communication, such as auditory, visual or olfactory cues associated with person perception and gender processing, produce these effects. OBJECTIVES: To determine whether exposure to two forms of social stimuli (audio and visual) from a virtual male or female stranger modulates cold pressor task (CPT) pain reports. METHODS: Participants with similar demographic characteristics conducted a CPT in solitude, without the physical presence of an experimenter or another person. During the CPT, participants were exposed to the voice and image of a virtual male or female stranger. The voices had analogous vocal prosody, provided no semantic information (spoken in a foreign language) and differed only in pitch; the images depicted a middle-age male or female health care practitioner. RESULTS: Male participants, but not females, showed higher CPT pain intensity when they were exposed to the female stimuli compared with the male stimuli. Follow-up analyses showed that the association between the social stimuli and variability in pain sensitivity was not moderated by individual differences in subjective (eg, self-image) or objective measurements of one’s physical stature. DISCUSSION: The findings show that exposure to virtual, gender-based auditory and visual social stimuli influences exogenous pain sensitivity. CONCLUSION: Further research on how contextual factors, such as the vocal properties of health care examiners and exposure to background voices, may influence momentary pain perception is necessary for creating more standardized methods for measuring patient pain reports in clinical settings. PMID:24911175

  6. Fitting methods for baryon acoustic oscillations in the Lyman-α forest fluctuations in BOSS data release 9

    SciTech Connect

    Kirkby, David; Margala, Daniel; Blomqvist, Michael; Slosar, Anže; Bailey, Stephen; Carithers, Bill; Busca, Nicolás G.; Bautista, Julian E.; Brownstein, Joel R.; Dawson, Kyle S.; Croft, Rupert A.C.; Font-Ribera, Andreu; Miralda-Escudé, Jordi; Myers, Adam D.; Nichol, Robert C.; Pâris, Isabelle; Petitjean, Patrick; and others

    2013-03-01

    We describe fitting methods developed to analyze fluctuations in the Lyman-α forest and measure the parameters of baryon acoustic oscillations (BAO). We apply our methods to BOSS Data Release 9. Our method is based on models of the three-dimensional correlation function in physical coordinate space, and includes the effects of redshift-space distortions, anisotropic non-linear broadening, and broadband distortions. We allow for independent scale factors along and perpendicular to the line of sight to minimize the dependence on our assumed fiducial cosmology and to obtain separate measurements of the BAO angular and relative velocity scales. Our fitting software and the input files needed to reproduce our main BOSS Data Release 9 results are publicly available.

  7. Visual stimuli: past and present

    NASA Astrophysics Data System (ADS)

    Westheimer, Gerald

    2013-03-01

    The fundamental properties of light and the principles of the structure and function of the visual system were discovered at a time when the only light sources were the sun and the flame of a candle. Contributions by Newton, Huygens, Thomas Young and Purkinje, Helmholtz's ophthalmoscope - all preceded the first incandescent filament. Light bulbs, Xenon arcs, lasers, light-emitting diodes (LEDs), computer monitors then sequentially enlarged the arsenal, and so did the steps from Nicol prism to Polaroid in polarizing light, and from glass and interference filters to laser light in generating monochromatic light. Technological advances have a deep impact on the research topics at any one time, expanding their scope. In particular, utilization of computers now allows the generation and manipulation of targets permitting questions to be approached that could not have been envisaged at the dawn of the technological era of vision research. Just beyond the immediate grasp of even the most thoughtful vision scientist, however, is the concern that stimulus sets originating in mathematicians' and physicists' toolboxes fail to capture some essential ingredients indigenous to human vision. The quest to study vision with stimuli in its own terms continues.

  8. Tests of redshift-space distortions models in configuration space for the analysis of the BOSS final data release

    NASA Astrophysics Data System (ADS)

    White, Martin; Reid, Beth; Chuang, Chia-Hsun; Tinker, Jeremy L.; McBride, Cameron K.; Prada, Francisco; Samushia, Lado

    2015-02-01

    Observations of redshift-space distortions in spectroscopic galaxy surveys offer an attractive method for observing the build-up of cosmological structure, which depends both on the expansion rate of the Universe and our theory of gravity. In preparation for analysis of redshift-space distortions from the Baryon Oscillation Spectroscopic Survey (BOSS) final data release, we compare a number of analytic and phenomenological models, specified in configuration space, to mock catalogues derived in different ways from several N-body simulations. The galaxies in each mock catalogue have properties similar to those of the higher redshift galaxies measured by BOSS but differ in the details of how small-scale velocities and halo occupancy are determined. We find that all of the analytic models fit the simulations over a limited range of scales while failing at small scales. We discuss which models are most robust and on which scales they return reliable estimates of the rate of growth of structure: we find that models based on some form of resummation can fit our N-body data for BOSS-like galaxies above 30 h-1 Mpc well enough to return unbiased parameter estimates.

  9. Sloan Digital Sky Survey III (SDSS-III), Data Release 9, including the Baryon Oscillation Spectroscopic Survey (BOSS)

    DOE Data Explorer

    The Third Sloan Digital Sky Survey (SDSS-III) has issued Data Release 9 (DR9), the first public release of data from the Baryon Oscillation Spectroscopic Survey (BOSS). In this release BOSS, the largest of SDSS-III’s four surveys, provides spectra for 535,995 newly observed galaxies, 102,100 quasars, and 116,474 stars, plus new information about objects in previous Sloan surveys (SDSS-I and II). Spectroscopy yields a wealth of information about astronomical objects including their motion (called redshift and written z), their composition, and sometimes also the density of the gas and other material that lies between them and observers on Earth. The new release lists spectra for galaxies with redshifts up to z = 0.8 (roughly 7 billion light years away) and quasars with redshifts between z = 2.1 and 3.5 (from 10 to 11.5 billion light years away). When BOSS is complete it will have measured 1.5 million galaxies and at least 150,000 quasars, as well as many thousands of stars and other ancillary objects for scientific projects other than BOSS’s main goal. [extracts copied from LBL news release of August 8, 2012

  10. The method of constant stimuli is inefficient

    NASA Technical Reports Server (NTRS)

    Watson, Andrew B.; Fitzhugh, Andrew

    1990-01-01

    Simpson (1988) has argued that the method of constant stimuli is as efficient as adaptive methods of threshold estimation and has supported this claim with simulations. It is shown that Simpson's simulations are not a reasonable model of the experimental process and that more plausible simulations confirm that adaptive methods are much more efficient that the method of constant stimuli.

  11. Intrinsic alignments of BOSS LOWZ galaxies - II. Impact of shape measurement methods

    NASA Astrophysics Data System (ADS)

    Singh, Sukhdeep; Mandelbaum, Rachel

    2016-04-01

    Measurements of intrinsic alignments of galaxy shapes with the large-scale density field, and the inferred intrinsic alignments model parameters, are sensitive to the shape measurement methods used. In this paper, we measure the intrinsic alignments of the Sloan Digital Sky Survey-III (SDSS-III) Baryon Oscillation Spectroscopic Survey (BOSS) low redshift (LOWZ) galaxies using three different shape measurement methods (re-Gaussianization, isophotal, and de Vaucouleurs), identifying a variation in the inferred intrinsic alignments amplitude at the 40 per cent level between these methods, independent of the galaxy luminosity or other properties. We also carry out a suite of systematics tests on the shapes and their two-point correlation functions, identifying a pronounced contribution from additive point spread function systematics in the de Vaucouleurs shapes. Since different methods measure galaxy shapes at different effective radii, the trends we identify in the intrinsic alignments amplitude are consistent with the interpretation that the outer regions of galaxy shapes are more responsive to tidal fields, resulting in isophote twisting and stronger alignments for isophotal shapes. We observe environment dependence of ellipticity, with brightest galaxies in groups being rounder on average compared to satellite and field galaxies. We also study the anisotropy in intrinsic alignments measurements introduced by projected shapes, finding effects consistent with predictions of the non-linear alignment model and hydrodynamic simulations. The large variations seen using the different shape measurement methods have important implications for intrinsic alignments forecasting and mitigation with future surveys.

  12. Testing cosmology with a catalogue of voids in the BOSS galaxy surveys

    NASA Astrophysics Data System (ADS)

    Nadathur, Seshadri

    2016-09-01

    We present a public catalogue of voids in the Baryon Oscillation Spectroscopic Survey (BOSS) Data Release 11 LOWZ and CMASS galaxy surveys. This catalogue contains information on the location, sizes, densities, shapes and bounding surfaces of 8956 independent, disjoint voids, making it the largest public void catalogue to date. Voids are identified using a version of the ZOBOV algorithm, the operation of which has been calibrated though tests on mock galaxy populations in N-body simulations, as well as on a suite of 4096 mock catalogues which fully reproduce the galaxy clustering, survey masks and selection functions. Based on this, we estimate a false positive detection rate of 3 per cent. Comparison with mock catalogues limits deviations of the void size distribution from that predicted in the ΛCDM model to be less than 6 per cent for voids with effective radius 8 < Rv < 60 h-1Mpc and in the redshift range 0.15 < z < 0.7. This could tightly constrain modified gravity scenarios and models with a varying equation of state, but we identify systematic biases which must be accounted for to reduce the theoretical uncertainty in the predictions for these models to the current level of precision attained from the data. We also examine the distribution of void densities and identify a deficit of the deepest voids relative to ΛCDM expectations, which is significant at more than the 3σ equivalent level. We discuss possible explanations for this discrepancy but at present its cause remains unknown.

  13. The BOSS-WiggleZ overlap region - I. Baryon acoustic oscillations

    NASA Astrophysics Data System (ADS)

    Beutler, Florian; Blake, Chris; Koda, Jun; Marín, Felipe A.; Seo, Hee-Jong; Cuesta, Antonio J.; Schneider, Donald P.

    2016-01-01

    We study the large-scale clustering of galaxies in the overlap region of the Baryon Oscillation Spectroscopic Survey (BOSS) CMASS sample and the WiggleZ Dark Energy Survey. We calculate the auto-correlation and cross-correlation functions in the overlap region of the two data sets and detect a Baryon Acoustic Oscillation (BAO) signal in each of them. The BAO measurement from the cross-correlation function represents the first such detection between two different galaxy surveys. After applying density-field reconstruction we report distance-scale measurements D_V r_s^fid / r_s = (1970 ± 45, 2132 ± 65, 2100 ± 200) Mpc from CMASS, the cross-correlation and WiggleZ, respectively. The distance scales derived from the two data sets are consistent, and are also robust against switching the displacement fields used for reconstruction between the two surveys. We use correlated mock realizations to calculate the covariance between the three BAO constraints. This approach can be used to construct a correlation matrix, permitting for the first time a rigorous combination of WiggleZ and CMASS BAO measurements. Using a volume-scaling technique, our result can also be used to combine WiggleZ and future CMASS DR12 results. Finally, we show that the relative velocity effect, a possible source of systematic uncertainty for the BAO technique, is consistent with zero for our samples.

  14. Testing cosmology with a catalogue of voids in the BOSS galaxy surveys

    NASA Astrophysics Data System (ADS)

    Nadathur, Seshadri

    2016-06-01

    We present a public catalogue of voids in the Baryon Oscillation Spectroscopic Survey (BOSS) Data Release 11 LOWZ and CMASS galaxy surveys. This catalogue contains information on the location, sizes, densities, shapes and bounding surfaces of 8956 independent, disjoint voids, making it the largest public void catalogue to date. Voids are identified using a version of the ZOBOV algorithm, the operation of which has been calibrated though tests on mock galaxy populations in N-body simulations, as well as on a suite of 4096 mock catalogues which fully reproduce the galaxy clustering, survey masks and selection functions. Based on this, we estimate a false positive detection rate of 3%. Comparison with mock catalogues limits deviations of the void size distribution from that predicted in the ΛCDM model to be less than 6% for voids with effective radius 8 < Rv < 60 h-1Mpc and in the redshift range 0.15 < z < 0.7. This could tightly constrain modified gravity scenarios and models with a varying equation of state, but we identify systematic biases which must be accounted for to reduce the theoretical uncertainty in the predictions for these models to the current level of precision attained from the data. We also examine the distribution of void densities and identify a deficit of the deepest voids relative to ΛCDM expectations, which is significant at more than the 3σ equivalent level. We discuss possible explanations for this discrepancy but at present its cause remains unknown.

  15. THE BOSS EMISSION-LINE LENS SURVEY (BELLS). I. A LARGE SPECTROSCOPICALLY SELECTED SAMPLE OF LENS GALAXIES AT REDSHIFT {approx}0.5

    SciTech Connect

    Brownstein, Joel R.; Bolton, Adam S.; Pandey, Parul; Schlegel, David J.; Eisenstein, Daniel J.; Kochanek, Christopher S.; Connolly, Natalia; Maraston, Claudia; Seitz, Stella; Wake, David A.; Wood-Vasey, W. Michael; Brinkmann, Jon; Schneider, Donald P.; Weaver, Benjamin A.

    2012-01-01

    We present a catalog of 25 definite and 11 probable strong galaxy-galaxy gravitational lens systems with lens redshifts 0.4 {approx}< z {approx}< 0.7, discovered spectroscopically by the presence of higher-redshift emission lines within the Baryon Oscillation Spectroscopic Survey (BOSS) of luminous galaxies, and confirmed with high-resolution Hubble Space Telescope (HST) images of 44 candidates. Our survey extends the methodology of the Sloan Lens Advanced Camera for Surveys survey (SLACS) to higher redshift. We describe the details of the BOSS spectroscopic candidate detections, our HST ACS image processing and analysis methods, and our strong gravitational lens modeling procedure. We report BOSS spectroscopic parameters and ACS photometric parameters for all candidates, and mass-distribution parameters for the best-fit singular isothermal ellipsoid models of definite lenses. Our sample to date was selected using only the first six months of BOSS survey-quality spectroscopic data. The full five-year BOSS database should produce a sample of several hundred strong galaxy-galaxy lenses and in combination with SLACS lenses at lower redshift, strongly constrain the redshift evolution of the structure of elliptical, bulge-dominated galaxies as a function of luminosity, stellar mass, and rest-frame color, thereby providing a powerful test for competing theories of galaxy formation and evolution.

  16. Generalized Habituation of Concept Stimuli in Toddlers

    ERIC Educational Resources Information Center

    Faulkender, Patricia J.; And Others

    1974-01-01

    An evaluation of selective generalization of habituation on the basis of meaningful categories of stimuli. Also explored are the sex differences in conceptual generalization of habituation. Subjects were 36 toddlers with a mean age of 40 months. (SDH)

  17. Stimuli, Reinforcers, and the Persistence of Behavior

    ERIC Educational Resources Information Center

    Nevin, John A.

    2009-01-01

    This article reviews evidence from basic and translational research with pigeons and humans suggesting that the persistence of operant behavior depends on the contingency between stimuli and reinforcers, and considers some implications for clinical interventions. (Contains 4 figures.)

  18. Binocular Combination of Second-Order Stimuli

    PubMed Central

    Zhou, Jiawei; Liu, Rong; Zhou, Yifeng; Hess, Robert F.

    2014-01-01

    Phase information is a fundamental aspect of visual stimuli. However, the nature of the binocular combination of stimuli defined by modulations in contrast, so-called second-order stimuli, is presently not clear. To address this issue, we measured binocular combination for first- (luminance modulated) and second-order (contrast modulated) stimuli using a binocular phase combination paradigm in seven normal adults. We found that the binocular perceived phase of second-order gratings depends on the interocular signal ratio as has been previously shown for their first order counterparts; the interocular signal ratios when the two eyes were balanced was close to 1 in both first- and second-order phase combinations. However, second-order combination is more linear than previously found for first-order combination. Furthermore, binocular combination of second-order stimuli was similar regardless of whether the carriers in the two eyes were correlated, anti-correlated, or uncorrelated. This suggests that, in normal adults, the binocular phase combination of second-order stimuli occurs after the monocular extracting of the second-order modulations. The sensory balance associated with this second-order combination can be obtained from binocular phase combination measurements. PMID:24404180

  19. Binocular combination of second-order stimuli.

    PubMed

    Zhou, Jiawei; Liu, Rong; Zhou, Yifeng; Hess, Robert F

    2014-01-01

    Phase information is a fundamental aspect of visual stimuli. However, the nature of the binocular combination of stimuli defined by modulations in contrast, so-called second-order stimuli, is presently not clear. To address this issue, we measured binocular combination for first- (luminance modulated) and second-order (contrast modulated) stimuli using a binocular phase combination paradigm in seven normal adults. We found that the binocular perceived phase of second-order gratings depends on the interocular signal ratio as has been previously shown for their first order counterparts; the interocular signal ratios when the two eyes were balanced was close to 1 in both first- and second-order phase combinations. However, second-order combination is more linear than previously found for first-order combination. Furthermore, binocular combination of second-order stimuli was similar regardless of whether the carriers in the two eyes were correlated, anti-correlated, or uncorrelated. This suggests that, in normal adults, the binocular phase combination of second-order stimuli occurs after the monocular extracting of the second-order modulations. The sensory balance associated with this second-order combination can be obtained from binocular phase combination measurements. PMID:24404180

  20. Speed Judgements of Transparent Stimuli

    NASA Technical Reports Server (NTRS)

    Mulligan, Jeffrey B.; Null, Cynthia H. (Technical Monitor)

    1996-01-01

    When two moving patterns are combined additively, observers often perceive two transparent surfaces, even when there are no cues supporting this segmentation in a frozen snapshot. We examined the ability of observers to make quantitative judgments about the speed of one of the patterns under these conditions. The component patterns consisted of band-pass filtered random noise presented in a spatial Gaussian contrast envelope, presented for 250 ms. On each trial a standard pattern appeared on one side of the fixation point, while a test pattern appeared on the other. The test pattern moved in the same direction as the standard, but with a speed which varied from trial to trial using a staircase procedure. The subjects' task was to report the side of the fixation point on which faster motion was seen. In some conditions the test stimulus was made to appear transparent by adding a mask pattern. When the mask was stationary, or moved slowly with respect to the test, no significant biases were introduced and discrimination performance was comparable to the no-mask condition (typically 3%). If the mask moved over the test with similar speed, however, the task became much harder, regardless of whether the mask moved opposite or orthogonal to the test. (Some subjects commented on a perceived directional repulsion between tests and orthogonally moving masks.) These results suggest the use of non-directional temporal channels in the performance of the speed discrimination task.

  1. Fractionated Reaction Time Responses to Auditory and Electrocutaneous Stimuli.

    ERIC Educational Resources Information Center

    Beehler, Pamela J. Hoyes; Kamen, Gary

    1986-01-01

    An investigation was conducted to equate auditory and electrocutaneous stimuli. These equated stimuli were used in a second investigation examining neuromotor responses to stimuli of varying intensity. Results are provided. (Author/MT)

  2. Fishy Fishes: The Typicality of Object Stimuli Used to Assess Children's Language in the Reynell Development Language Scales--III

    ERIC Educational Resources Information Center

    Syrnyk, Corinne; Meints, Kerstin

    2012-01-01

    Background: Numerous studies show clear evidence that children display typicality effects during early word learning. However, little is known of the typicality of stimuli used by standardized language tests to assess children's language development. Aims: To examine the typicality of stimuli used by the Reynell Developmental Language Scales--III…

  3. Visual tracking of auditory stimuli.

    PubMed

    Stream, R W; Whitson, E T; Honrubia, V

    1980-07-01

    A white noise sound stimulus was emitted successively in an anechoic chamber across 24 loudspeakers equally spaced in the horizontal plane in a semicircle with diameter of 11 ft. Eye movements produced by each of 20 normal-hearing young adults in the center of this arc who tracked the sound at 10 different velocities (15--180 degrees/sec) were recorded with standard ENG methods. During each rotating cycle of the stimulus the eyes were able to follow the sound with discrete saccades, but did not produce nystagmic-like movements. Increased stimulus velocity resulted in (1) diminution of the amplitude of the tracking cycles, (2) decrease in the number of saccades, and (3) increase in the average velocity of the eye. Ss performed better with lights on than off. The additional quantitative findings from the present study further indicate the limitation in the ability of human Ss to localize a moving acoustic source in space. PMID:7347744

  4. Emotional stimuli and motor conversion disorder

    PubMed Central

    Brezing, Christina; Gallea, Cecile; Ameli, Rezvan; Roelofs, Karin; LaFrance, W. Curt; Hallett, Mark

    2010-01-01

    Conversion disorder is characterized by neurological signs and symptoms related to an underlying psychological issue. Amygdala activity to affective stimuli is well characterized in healthy volunteers with greater amygdala activity to both negative and positive stimuli relative to neutral stimuli, and greater activity to negative relative to positive stimuli. We investigated the relationship between conversion disorder and affect by assessing amygdala activity to affective stimuli. We conducted a functional magnetic resonance imaging study using a block design incidental affective task with fearful, happy and neutral face stimuli and compared valence contrasts between 16 patients with conversion disorder and 16 age- and gender-matched healthy volunteers. The patients with conversion disorder had positive movements such as tremor, dystonia or gait abnormalities. We also assessed functional connectivity between the amygdala and regions associated with motor preparation. A group by affect valence interaction was observed. Post hoc analyses revealed that whereas healthy volunteers had greater right amygdala activity to fearful versus neutral compared with happy versus neutral as expected, there were no valence differences in patients with conversion disorder. There were no group differences observed. The time course analysis also revealed greater right amygdala activity in patients with conversion disorder for happy stimuli (t = 2.96, P = 0.006) (with a trend for fearful stimuli, t = 1.81, P = 0.08) compared with healthy volunteers, with a pattern suggestive of impaired amygdala habituation even when controlling for depressive and anxiety symptoms. Using psychophysiological interaction analysis, patients with conversion disorder had greater functional connectivity between the right amygdala and the right supplementary motor area during both fearful versus neutral, and happy versus neutral ‘stimuli’ compared with healthy volunteers. These results were confirmed with

  5. Probing the circumgalactic medium at high-redshift using composite BOSS spectra of strong Lyman α forest absorbers

    NASA Astrophysics Data System (ADS)

    Pieri, Matthew M.; Mortonson, Michael J.; Frank, Stephan; Crighton, Neil; Weinberg, David H.; Lee, Khee-Gan; Noterdaeme, Pasquier; Bailey, Stephen; Busca, Nicolas; Ge, Jian; Kirkby, David; Lundgren, Britt; Mathur, Smita; Pâris, Isabelle; Palanque-Delabrouille, Nathalie; Petitjean, Patrick; Rich, James; Ross, Nicholas P.; Schneider, Donald P.; York, Donald G.

    2014-06-01

    We present composite spectra constructed from a sample of 242 150 Lyman α (Lyα) forest absorbers at redshifts 2.4 < z < 3.1 identified in quasar spectra from the Baryon Oscillation Spectroscopic Survey (BOSS) as part of Data Release 9 of the Sloan Digital Sky Survey III. We select forest absorbers by their flux in bins 138 km s-1 wide (approximately the size of the BOSS resolution element). We split these absorbers into five samples spanning the range of flux -0.05 ≤ F < 0.45. Tests on a smaller set of high-resolution spectra show that our three strongest absorption samples would probe circumgalactic regions (projected separation <300 proper kpc and |Δv| < 300 km s-1) in about 60 per cent of cases for very high signal-to-noise ratio. Within this subset, weakening Lyα absorption is associated with decreasing purity of circumgalactic selection once BOSS noise is included. Our weaker two Lyα absorption samples are dominated by the intergalactic medium. We present composite spectra of these samples and a catalogue of measured absorption features from H I and 13 metal ionization species, all of which we make available to the community. We compare measurements of seven Lyman series transitions in our composite spectra to single line models and obtain further constraints from their associated excess Lyman limit opacity. This analysis provides results consistent with column densities over the range 14.4 ≲ log (N_{H I}) ≲ 16.45. We compare our measurements of metal absorption to a variety of simple single-line, single-phase models for a preliminary interpretation. Our results imply clumping on scales down to ˜30 pc and near-solar metallicities in the circumgalactic samples, while high-ionization metal absorption consistent with typical IGM densities and metallicities is visible in all samples.

  6. Near-ultraviolet Spectroscopy of Star-forming Galaxies from eBOSS: Signatures of Ubiquitous Galactic-scale Outflows

    NASA Astrophysics Data System (ADS)

    Zhu, Guangtun Ben; Comparat, Johan; Kneib, Jean-Paul; Delubac, Timothée; Raichoor, Anand; Dawson, Kyle S.; Newman, Jeffrey; Yèche, Christophe; Zhou, Xu; Schneider, Donald P.

    2015-12-01

    We present rest-frame near-ultraviolet (NUV) spectroscopy of star-forming galaxies (SFGs) at 0.6 < z < 1.2 from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS) in SDSS-IV. One of the eBOSS programs is to obtain 2″ (about 15 kpc) fiber spectra of about 200,000 emission-line galaxies (ELGs) at redshift z ≳ 0.6. We use the data from the pilot observations of this program, including 8620 spectra of SFGs at 0.6 < z < 1.2. The median composite spectra of these SFGs at 2200 Å < λ < 4000 Å feature asymmetric, preferentially blueshifted non-resonant emission, Fe ii*, and blueshifted resonant absorption, e.g., Fe ii and Mg ii, indicating ubiquitous outflows driven by star formation at these redshifts. For the absorption lines, we find a variety of velocity profiles with different degrees of blueshift. Comparing our new observations with the literature, we do not observe the non-resonant emission in the small-aperture (<40 pc) spectra of local star-forming regions with the Hubble Space Telescope, and find the observed line ratios in the SFG spectra to be different from those in the spectra of local star-forming regions, as well as those of quasar absorption-line systems in the same redshift range. We introduce an outflow model that can simultaneously explain the multiple observed properties and suggest that the variety of absorption velocity profiles and the line ratio differences are caused by scattered fluorescent emission filling in on top of the absorption in the large-aperture eBOSS spectra. We develop an observation-driven, model-independent method to correct the emission infill to reveal the true absorption profiles. Finally, we show that the strengths of both the non-resonant emission and the emission-corrected resonant absorption increase with [O ii] λλ3727, 3730 rest equivalent width and luminosity, with a slightly larger dependence on the former. Our results show that the eBOSS and future dark-energy surveys (e.g., Dark Energy Spectroscopic

  7. Short term memory for tactile stimuli.

    PubMed

    Gallace, Alberto; Tan, Hong Z; Haggard, Patrick; Spence, Charles

    2008-01-23

    Research has shown that unreported information stored in rapidly decaying visual representations may be accessed more accurately using partial report than using full report procedures (e.g., [Sperling, G., 1960. The information available in brief visual presentations. Psychological Monographs, 74, 1-29.]). In the 3 experiments reported here, we investigated whether unreported information regarding the actual number of tactile stimuli presented in parallel across the body surface can be accessed using a partial report procedure. In Experiment 1, participants had to report the total number of stimuli in a tactile display composed of up to 6 stimuli presented across their body (numerosity task), or else to detect whether or not a tactile stimulus had previously been presented in a position indicated by a visual probe given at a variable delay after offset of a tactile display (i.e., partial report). The results showed that participants correctly reported up to 3 stimuli in the numerosity judgment task, but their performance was significantly better than chance when up to 5 stimuli were presented in the partial report task. This result shows that short-lasting tactile representations can be accessed using partial report procedures similar to those used previously in visual studies. Experiment 2 showed that the duration of these representations (or the time available to consciously access them) depends on the number of stimuli presented in the display (the greater the number of stimuli that are presented, the faster their representation decays). Finally, the results of a third experiment showed that the differences in performance between the numerosity judgment and partial report tasks could not be explained solely in terms of any difference in task difficulty. PMID:18083147

  8. Lack of sleep affects the evaluation of emotional stimuli.

    PubMed

    Tempesta, Daniela; Couyoumdjian, Alessandro; Curcio, Giuseppe; Moroni, Fabio; Marzano, Cristina; De Gennaro, Luigi; Ferrara, Michele

    2010-04-29

    Sleep deprivation (SD) negatively affects various cognitive performances, but surprisingly evidence about a specific impact of sleep loss on subjective evaluation of emotional stimuli remains sparse. In the present study, we assessed the effect of SD on the emotional rating of standardized visual stimuli selected from the International Affective Picture System. Forty university students were assigned to the sleep group (n=20), tested before and after one night of undisturbed sleep at home, or to the deprivation group, tested before and after one night of total SD. One-hundred and eighty pictures (90 test, 90 retest) were selected and categorized as pleasant, neutral and unpleasant. Participants were asked to judge their emotional reactions while viewing pictures by means of the Self-Assessment Manikin. Subjective mood ratings were also obtained by means of Visual Analog Scales. No significant effect of SD was observed on the evaluation of pleasant and unpleasant stimuli. On the contrary, SD subjects perceived the neutral pictures more negatively and showed an increase of negative mood and a decrease of subjective alertness compared to non-deprived subjects. Finally, an analysis of covariance on mean valence ratings of neutral pictures using negative mood as covariate confirmed the effect of SD. Our results indicate that sleep is involved in regulating emotional evaluation. The emotional labeling of neutral stimuli biased toward negative responses was not mediated by the increase of negative mood. This effect can be interpreted as an adaptive reaction supporting the "better safe than sorry" principle. It may also have applied implications for healthcare workers, military and law-enforcement personnel. PMID:20117179

  9. NESSTI: Norms for Environmental Sound Stimuli

    PubMed Central

    Hocking, Julia; Dzafic, Ilvana; Kazovsky, Maria; Copland, David A.

    2013-01-01

    In this paper we provide normative data along multiple cognitive and affective variable dimensions for a set of 110 sounds, including living and manmade stimuli. Environmental sounds are being increasingly utilized as stimuli in the cognitive, neuropsychological and neuroimaging fields, yet there is no comprehensive set of normative information for these type of stimuli available for use across these experimental domains. Experiment 1 collected data from 162 participants in an on-line questionnaire, which included measures of identification and categorization as well as cognitive and affective variables. A subsequent experiment collected response times to these sounds. Sounds were normalized to the same length (1 second) in order to maximize usage across multiple paradigms and experimental fields. These sounds can be freely downloaded for use, and all response data have also been made available in order that researchers can choose one or many of the cognitive and affective dimensions along which they would like to control their stimuli. Our hope is that the availability of such information will assist researchers in the fields of cognitive and clinical psychology and the neuroimaging community in choosing well-controlled environmental sound stimuli, and allow comparison across multiple studies. PMID:24023866

  10. Recall and recognition hypermnesia for Socratic stimuli.

    PubMed

    Kazén, Miguel; Solís-Macías, Víctor M

    2016-01-01

    In two experiments, we investigate hypermnesia, net memory improvements with repeated testing of the same material after a single study trial. In the first experiment, we found hypermnesia across three trials for the recall of word solutions to Socratic stimuli (dictionary-like definitions of concepts) replicating Erdelyi, Buschke, and Finkelstein and, for the first time using these materials, for their recognition. In the second experiment, we had two "yes/no" recognition groups, a Socratic stimuli group presented with concrete and abstract verbal materials and a word-only control group. Using signal detection measures, we found hypermnesia for concrete Socratic stimuli-and stable performance for abstract stimuli across three recognition tests. The control group showed memory decrements across tests. We interpret these findings with the alternative retrieval pathways (ARP) hypothesis, contrasting it with alternative theories of hypermnesia, such as depth of processing, generation and retrieve-recognise. We conclude that recognition hypermnesia for concrete Socratic stimuli is a reliable phenomenon, which we found in two experiments involving both forced-choice and yes/no recognition procedures. PMID:25523628

  11. Stimuli-responsive dendrimers in drug delivery.

    PubMed

    Wang, Hui; Huang, Quan; Chang, Hong; Xiao, Jianru; Cheng, Yiyun

    2016-03-01

    Dendrimers have shown great promise as carriers in drug delivery due to their unique structures and superior properties. However, the precise control of payload release from a dendrimer matrix still presents a great challenge. Stimuli-responsive dendrimers that release payloads in response to a specific trigger could offer distinct clinical advantages over those dendrimers that release payloads passively. These smart polymers are designed to specifically release their payloads at targeted regions or at constant release profiles for specific therapies. They represent an attractive alternative to targeted dendrimers and enable dendrimer-based therapeutics to be more effective, more convenient, and much safer. The wide range of stimuli, either endogenous (acid, enzyme, and redox potentials) or exogenous (light, ultrasound, and temperature change), allows great flexibility in the design of stimuli-responsive dendrimers. In this review article, we will highlight recent advances and opportunities in the development of stimuli-responsive dendrimers for the treatment of various diseases, with emphasis on cancer. Specifically, the applications of stimuli-responsive dendrimers in drug delivery as well as their mechanisms are intensively reviewed. PMID:26806314

  12. Stimuli-responsive materials in analytical separation.

    PubMed

    Lorenzo, Rosa A; Carro, Antonia M; Concheiro, Angel; Alvarez-Lorenzo, Carmen

    2015-07-01

    This review focuses on the fundamentals of stimuli-responsive materials and their applications to three common separation techniques, namely extraction, chromatography, and electrophoresis. Although still little investigated, materials that switch their affinity for the analyte on and off as a function of tiny changes in physical and biochemical variables offer relevant advantages for analyte extraction, concentration, and separation. Temperature and/or pH-responsive polymers in the form of chains or networks, which are dispersed in the sample as free entities or after being grafted onto beads (which may incorporate magnetic cores), enable quantitative capture and/or elution of the analyte under mild conditions and without needing organic solvents. Regarding liquid-chromatography separation, responsive stationary phases enable the implementation of "all-in-water" procedures in which retention times are modulated by means of temperature or pH gradients. Other stimuli that can be externally applied, for example light or magnetic fields, can also be used for efficient extraction or separation of the target substance without altering the composition of the sample matrix. Moreover, stimuli-responsiveness enables straightforward recycling of solid and/or stationary phases for a prolonged lifetime. Improved understanding of the phase transitions of stimuli-responsive materials and design of suitable formats for analytical applications should enable wider and more successful application of stimuli-responsive materials in analytical separations. PMID:25910881

  13. The impact of extraversion on attentional bias to pleasant stimuli: neuroticism matters.

    PubMed

    Lou, Yixue; Meng, Xianxin; Yang, Jiemin; Zhang, Shu; Long, Quanshan; Yuan, Jiajin

    2016-03-01

    The present study explored whether neuroticism modulates the impact of extraversion on attention orienting to pleasant and unpleasant pictures of diverse emotional intensities. We measured event-related potentials for highly emotional, mildly emotional, and neutral stimuli in both pleasant and unpleasant blocks, while subjects (16 stable ambiverts, 15 stable extraverts, 17 neurotic ambiverts, and 17 neurotic extraverts) were asked to perform a standard/deviant categorization task, irrespective of the emotionality of the deviants. The results revealed a modulation effect of neuroticism in the impact of extraversion on emotional attention. On the one hand, irrespective of extraversion, emotionally stable samples showed increased N200 amplitudes for highly unpleasant (HN) stimuli relative to mildly unpleasant (MN) and neutral stimuli, while these samples exhibited no significant emotion magnitude effect in the pleasant block. On the other hand, although neurotic samples, both extraverts and ambiverts, showed enhanced N2 amplitudes for HN stimuli than neutral stimuli, neurotic extraverts displayed increased N2 amplitudes for highly pleasant (HP) and mildly pleasant (MP) stimuli than neutral stimuli, which was absent in neurotic ambiverts. These results extend our understanding of the relationship between extraversion and emotion by showing that neuroticism amplifies the positive emotional bias of extraverts. PMID:26586271

  14. On hemispheric differences in evoked potentials to speech stimuli

    NASA Technical Reports Server (NTRS)

    Galambos, R.; Benson, P.; Smith, T. S.; Schulman-Galambos, C.; Osier, H.

    1975-01-01

    Confirmation is provided for the belief that evoked potentials may reflect differences in hemispheric functioning that are marginal at best. Subjects were right-handed and audiologically normal men and women, and responses were recorded using standard EEG techniques. Subjects were instructed to listen for the targets while laying in a darkened sound booth. Different stimuli, speech and tone signals, were used. Speech sounds were shown to evoke a response pattern that resembles that to tone or clicks. Analysis of variances on peak amplitude and latency measures showed no significant differences between hemispheres, however, a Wilcoxon test showed significant differences in hemispheres for certain target tasks.

  15. Comparing Identification of Standardized and Regionally Valid Vowels

    ERIC Educational Resources Information Center

    Wright, Richard; Souza, Pamela

    2012-01-01

    Purpose: In perception studies, it is common to use vowel stimuli from standardized recordings or synthetic stimuli created using values from well-known published research. Although the use of standardized stimuli is convenient, unconsidered dialect and regional accent differences may introduce confounding effects. The goal of this study was to…

  16. Verbal Establishing Stimuli: Testing the Motivative Effect of Stimuli in a Derived Relation with Consequences

    ERIC Educational Resources Information Center

    Ju, Winifred C.; Hayes, Steven C.

    2008-01-01

    The present study examined whether the presentation of stimuli in equivalence relations with consequences increases the operant behavior that produces these consequences. In Experiment 1, both normal words and experimentally trained equivalence stimuli did so with young children. In Experiment 2, results were similar with college students. Here, a…

  17. VEP Responses to Op-Art Stimuli

    PubMed Central

    O’Hare, Louise; Clarke, Alasdair D. F.; Pollux, Petra M. J.

    2015-01-01

    Several types of striped patterns have been reported to cause adverse sensations described as visual discomfort. Previous research using op-art-based stimuli has demonstrated that spurious eye movement signals can cause the experience of illusory motion, or shimmering effects, which might be perceived as uncomfortable. Whilst the shimmering effects are one cause of discomfort, another possible contributor to discomfort is excessive neural responses: As striped patterns do not have the statistical redundancy typical of natural images, they are perhaps unable to be encoded efficiently. If this is the case, then this should be seen in the amplitude of the EEG response. This study found that stimuli that were judged to be most comfortable were also those with the lowest EEG amplitude. This provides some support for the idea that excessive neural responses might also contribute to discomfort judgements in normal populations, in stimuli controlled for perceived contrast. PMID:26422207

  18. Non-target adjacent stimuli classification improves performance of classical ERP-based brain computer interface

    NASA Astrophysics Data System (ADS)

    Ceballos, G. A.; Hernández, L. F.

    2015-04-01

    Objective. The classical ERP-based speller, or P300 Speller, is one of the most commonly used paradigms in the field of Brain Computer Interfaces (BCI). Several alterations to the visual stimuli presentation system have been developed to avoid unfavorable effects elicited by adjacent stimuli. However, there has been little, if any, regard to useful information contained in responses to adjacent stimuli about spatial location of target symbols. This paper aims to demonstrate that combining the classification of non-target adjacent stimuli with standard classification (target versus non-target) significantly improves classical ERP-based speller efficiency. Approach. Four SWLDA classifiers were trained and combined with the standard classifier: the lower row, upper row, right column and left column classifiers. This new feature extraction procedure and the classification method were carried out on three open databases: the UAM P300 database (Universidad Autonoma Metropolitana, Mexico), BCI competition II (dataset IIb) and BCI competition III (dataset II). Main results. The inclusion of the classification of non-target adjacent stimuli improves target classification in the classical row/column paradigm. A gain in mean single trial classification of 9.6% and an overall improvement of 25% in simulated spelling speed was achieved. Significance. We have provided further evidence that the ERPs produced by adjacent stimuli present discriminable features, which could provide additional information about the spatial location of intended symbols. This work promotes the searching of information on the peripheral stimulation responses to improve the performance of emerging visual ERP-based spellers.

  19. IGM Constraints from the SDSS-III/BOSS DR9 Lyα Forest Transmission Probability Distribution Function

    NASA Astrophysics Data System (ADS)

    Lee, Khee-Gan; Hennawi, Joseph F.; Spergel, David N.; Weinberg, David H.; Hogg, David W.; Viel, Matteo; Bolton, James S.; Bailey, Stephen; Pieri, Matthew M.; Carithers, William; Schlegel, David J.; Lundgren, Britt; Palanque-Delabrouille, Nathalie; Suzuki, Nao; Schneider, Donald P.; Yèche, Christophe

    2015-02-01

    The Lyα forest transmission probability distribution function (PDF) is an established probe of the intergalactic medium (IGM) astrophysics, especially the temperature-density relationship of the IGM. We measure the transmission PDF from 3393 Baryon Oscillations Spectroscopic Survey (BOSS) quasars from Sloan Digital Sky Survey Data Release 9, and compare with mock spectra that include careful modeling of the noise, continuum, and astrophysical uncertainties. The BOSS transmission PDFs, measured at langzrang = [2.3, 2.6, 3.0], are compared with PDFs created from mock spectra drawn from a suite of hydrodynamical simulations that sample the IGM temperature-density relationship, γ, and temperature at mean density, T 0, where T(Δ) = T 0Δγ - 1. We find that a significant population of partial Lyman-limit systems (LLSs) with a column-density distribution slope of βpLLS ~ - 2 are required to explain the data at the low-transmission end of transmission PDF, while uncertainties in the mean Lyα forest transmission affect the high-transmission end. After modeling the LLSs and marginalizing over mean transmission uncertainties, we find that γ = 1.6 best describes the data over our entire redshift range, although constraints on T 0 are affected by systematic uncertainties. Within our model framework, isothermal or inverted temperature-density relationships (γ <= 1) are disfavored at a significance of over 4σ, although this could be somewhat weakened by cosmological and astrophysical uncertainties that we did not model.

  20. The one-dimensional Lyα forest power spectrum from BOSS

    NASA Astrophysics Data System (ADS)

    Palanque-Delabrouille, Nathalie; Yèche, Christophe; Borde, Arnaud; Le Goff, Jean-Marc; Rossi, Graziano; Viel, Matteo; Aubourg, Éric; Bailey, Stephen; Bautista, Julian; Blomqvist, Michael; Bolton, Adam; Bolton, James S.; Busca, Nicolás G.; Carithers, Bill; Croft, Rupert A. C.; Dawson, Kyle S.; Delubac, Timothée; Font-Ribera, Andreu; Ho, Shirley; Kirkby, David; Lee, Khee-Gan; Margala, Daniel; Miralda-Escudé, Jordi; Muna, Demitri; Myers, Adam D.; Noterdaeme, Pasquier; Pâris, Isabelle; Petitjean, Patrick; Pieri, Matthew M.; Rich, James; Rollinde, Emmanuel; Ross, Nicholas P.; Schlegel, David J.; Schneider, Donald P.; Slosar, Anže; Weinberg, David H.

    2013-11-01

    We have developed two independent methods for measuring the one-dimensional power spectrum of the transmitted flux in the Lyman-α forest. The first method is based on a Fourier transform and the second on a maximum-likelihood estimator. The two methods are independent and have different systematic uncertainties. Determination of the noise level in the data spectra was subject to a new treatment, because of its significant impact on the derived power spectrum. We applied the two methods to 13 821 quasar spectra from SDSS-III/BOSS DR9 selected from a larger sample of over 60 000 spectra on the basis of their high quality, high signal-to-noise ratio (S/N), and good spectral resolution. The power spectra measured using either approach are in good agreement over all twelve redshift bins from ⟨z⟩ = 2.2 to ⟨z⟩ = 4.4, and scales from 0.001 km s-1 to 0.02 km s-1. We determined the methodological andinstrumental systematic uncertainties of our measurements. We provide a preliminary cosmological interpretation of our measurements using available hydrodynamical simulations. The improvement in precision over previously published results from SDSS is a factor 2-3 for constraints on relevant cosmological parameters. For a ΛCDM model and using a constraint on H0 that encompasses measurements based on the local distance ladder and on CMB anisotropies, we infer σ8 = 0.83 ± 0.03 and ns = 0.97 ± 0.02 based on H i absorption in the range 2.1 < z < 3.7. The measured values of the power spectrum and correlation matrices for all scales and all redshifts (full Tables 4 and 5) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/559/A85

  1. The Lyman-α forest in three dimensions: measurements of large scale flux correlations from BOSS 1st-year data

    SciTech Connect

    Slosar, Anže; Font-Ribera, Andreu; Pieri, Matthew M.; Rich, James; Goff, Jean-Marc Le; Charlassier, Romain; Aubourg, Éric; Busca, Nicolas; Hamilton, Jean-Christophe; Carithers, Bill; Cortês, Marina; Ho, Shirley; McDonald, Patrick; Croft, Rupert; Dawson, Kyle S.; Eisenstein, Daniel; Lee, Khee-Gan; Lupton, Robert; Medolin, Bumbarija; and others

    2011-09-01

    Using a sample of approximately 14,000 z > 2.1 quasars observed in the first year of the Baryon Oscillation Spectroscopic Survey (BOSS), we measure the three-dimensional correlation function of absorption in the Lyman-α forest. The angle-averaged correlation function of transmitted flux (F = e{sup −τ}) is securely detected out to comoving separations of 60 h{sup −1}Mpc, the first detection of flux correlations across widely separated sightlines. A quadrupole distortion of the redshift-space correlation function by peculiar velocities, the signature of the gravitational instability origin of structure in the Lyman-α forest, is also detected at high significance. We obtain a good fit to the data assuming linear theory redshift-space distortion and linear bias of the transmitted flux, relative to the matter fluctuations of a standard ΛCDM cosmological model (inflationary cold dark matter with a cosmological constant). At 95% confidence, we find a linear bias parameter 0.16 < b < 0.24 and redshift-distortion parameter 0.44 < β < 1.20, at central redshift z = 2.25, with a well constrained combination b(1+β) = 0.336±0.012. The errors on β are asymmetric, with β = 0 excluded at over 5σ confidence level. The value of β is somewhat low compared to theoretical predictions, and our tests on synthetic data suggest that it is depressed (relative to expectations for the Lyman-α forest alone) by the presence of high column density systems and metal line absorption. These results set the stage for cosmological parameter determinations from three-dimensional structure in the Lyman-α forest, including anticipated constraints on dark energy from baryon acoustic oscillations.

  2. The Lyman-α forest in three dimensions: measurements of large scale flux correlations from BOSS 1st-year data

    NASA Astrophysics Data System (ADS)

    Slosar, Anže; Font-Ribera, Andreu; Pieri, Matthew M.; Rich, James; Le Goff, Jean-Marc; Aubourg, Éric; Brinkmann, Jon; Busca, Nicolas; Carithers, Bill; Charlassier, Romain; Cortês, Marina; Croft, Rupert; Dawson, Kyle S.; Eisenstein, Daniel; Hamilton, Jean-Christophe; Ho, Shirley; Lee, Khee-Gan; Lupton, Robert; McDonald, Patrick; Medolin, Bumbarija; Muna, Demitri; Miralda-Escudé, Jordi; Myers, Adam D.; Nichol, Robert C.; Palanque-Delabrouille, Nathalie; Pâris, Isabelle; Petitjean, Patrick; Piškur, Yodovina; Rollinde, Emmanuel; Ross, Nicholas P.; Schlegel, David J.; Schneider, Donald P.; Sheldon, Erin; Weaver, Benjamin A.; Weinberg, David H.; Yeche, Christophe; York, Donald G.

    2011-09-01

    Using a sample of approximately 14,000 z > 2.1 quasars observed in the first year of the Baryon Oscillation Spectroscopic Survey (BOSS), we measure the three-dimensional correlation function of absorption in the Lyman-α forest. The angle-averaged correlation function of transmitted flux (F = e-τ) is securely detected out to comoving separations of 60 h-1Mpc, the first detection of flux correlations across widely separated sightlines. A quadrupole distortion of the redshift-space correlation function by peculiar velocities, the signature of the gravitational instability origin of structure in the Lyman-α forest, is also detected at high significance. We obtain a good fit to the data assuming linear theory redshift-space distortion and linear bias of the transmitted flux, relative to the matter fluctuations of a standard ΛCDM cosmological model (inflationary cold dark matter with a cosmological constant). At 95% confidence, we find a linear bias parameter 0.16 < b < 0.24 and redshift-distortion parameter 0.44 < β < 1.20, at central redshift z = 2.25, with a well constrained combination b(1+β) = 0.336±0.012. The errors on β are asymmetric, with β = 0 excluded at over 5σ confidence level. The value of β is somewhat low compared to theoretical predictions, and our tests on synthetic data suggest that it is depressed (relative to expectations for the Lyman-α forest alone) by the presence of high column density systems and metal line absorption. These results set the stage for cosmological parameter determinations from three-dimensional structure in the Lyman-α forest, including anticipated constraints on dark energy from baryon acoustic oscillations.

  3. The large-scale cross-correlation of Damped Lyman alpha systems with the Lyman alpha forest: first measurements from BOSS

    SciTech Connect

    Font-Ribera, Andreu; Miralda-Escudé, Jordi; Arnau, Eduard; Carithers, Bill; Ross, Nicholas P.; White, Martin; Lee, Khee-Gan; Noterdaeme, Pasquier; Pâris, Isabelle; Petitjean, Patrick; Rollinde, Emmanuel; Rich, James; Schneider, Donald P.; York, Donald G. E-mail: miralda@icc.ub.edu

    2012-11-01

    We present the first measurement of the large-scale cross-correlation of Lyα forest absorption and Damped Lyman α systems (DLA), using the 9th Data Release of the Baryon Oscillation Spectroscopic Survey (BOSS). The cross-correlation is clearly detected on scales up to 40h{sup −1}Mpc and is well fitted by the linear theory prediction of the standard Cold Dark Matter model of structure formation with the expected redshift distortions, confirming its origin in the gravitational evolution of structure. The amplitude of the DLA-Lyα cross-correlation depends on only one free parameter, the bias factor of the DLA systems, once the Lyα forest bias factors are known from independent Lyα forest correlation measurements. We measure the DLA bias factor to be b{sub D} = (2.17±0.20)β{sub F}{sup 0.22}, where the Lyα forest redshift distortion parameter β{sub F} is expected to be above unity. This bias factor implies a typical host halo mass for DLAs that is much larger than expected in present DLA models, and is reproduced if the DLA cross section scales with halo mass as M{sub h}{sup α}, with α = 1.1±0.1 for β{sub F} = 1. Matching the observed DLA bias factor and rate of incidence requires that atomic gas remains extended in massive halos over larger areas than predicted in present simulations of galaxy formation, with typical DLA proper sizes larger than 20 kpc in host halos of masses ∼ 10{sup 12}M{sub ☉}. We infer that typical galaxies at z ≅ 2 to 3 are surrounded by systems of atomic clouds that are much more extended than the luminous parts of galaxies and contain ∼ 10% of the baryons in the host halo.

  4. Potential bronchoconstrictor stimuli in acid fog.

    PubMed Central

    Balmes, J R; Fine, J M; Gordon, T; Sheppard, D

    1989-01-01

    Acid fog is complex and contains multiple stimuli that may be capable of inducing bronchoconstriction. These stimuli include sulfuric and niric acids, the principal inorganic acids present; sulfites, formed in the atmosphere as a reaction product of sulfur dioxide and water droplets; fog water itself, a hypoosmolar aerosol; the organic acid hydroxymethanesulfonate, the bisulfite adduct of formaldehyde; and gaseous pollutants, e.g., sulfur dioxide, oxides of nitrogen, ozone. Given this complexity, evaluation of the respiratory health effects of naturally occurring acid fog requires assessment of the bronchoconstrictor potency of each component stimulus and possible interactions among these stimuli. We summarize the results of three studies that involve characterization of the bronchoconstrictor potency of acid fog stimuli and/or their interaction in subjects with asthma. The results of the first study indicate that titratable acidity appears to be a more important stimulus to bronchoconstriction than is pH. The results of the second study demonstrate that sulfite species are capable of inducing bronchoconstriction, especially when inhaled at acid pH. The results of the third study suggest that acidity can potentiate hypoosmolar fog-induced bronchoconstriction. PMID:2539989

  5. Potential bronchoconstrictor stimuli in acid fog

    SciTech Connect

    Balmes, J.R.; Fine, J.M.; Gordon, T.; Sheppard, D.

    1989-02-01

    Acid fog is complex and contains multiple stimuli that may be capable of inducing bronchoconstriction. These stimuli include sulfuric and nitric acids, the principal inorganic acids present; sulfites, formed in the atmosphere as a reaction product of sulfur dioxide and water droplets; fog water itself, a hypoosmolar aerosol; the organic acid hydroxymethanesulfonate, the bisulfite adduct of formaldehyde; and gaseous pollutants, e.g., sulfur dioxide, oxides of nitrogen, ozone. Given this complexity, evaluation of the respiratory health effects of naturally occurring acid fog requires assessment of the bronchoconstrictor potency of each component stimulus and possible interactions among these stimuli. We summarize the results of three studies that involve characterization of the bronchoconstrictor potency of acid fog stimuli and/or their interaction in subjects with asthma. The results of the first study indicate that titratable acidity appears to be a more important stimulus to bronchoconstriction than is pH. The results of the second study demonstrate that sulfite species are capable of inducing bronchoconstriction, especially when inhaled at acid pH. The results of the third study suggest that acidity can potentiate hypoosmolar fog-induced bronchoconstriction.

  6. Categorization of Multidimensional Stimuli by Pigeons

    ERIC Educational Resources Information Center

    Berg, Mark E.; Grace, Randolph C.

    2011-01-01

    Six pigeons responded in a visual category learning task in which the stimuli were dimensionally separable Gabor patches that varied in frequency and orientation. We compared performance in two conditions which varied in terms of whether accurate performance required that responding be controlled jointly by frequency and orientation, or…

  7. Musicians' Perception of Beat in Monotonic Stimuli.

    ERIC Educational Resources Information Center

    Duke, Robert A.

    1989-01-01

    Assesses musicians' perceptions of beat in monotonic stimuli and attempts to define empirically the range of perceived beat tempo in music. Subjects performed a metric pulse in response to periodic stimulus tones. Results indicate a relatively narrow range within which beats are perceived by trained musicians. (LS)

  8. Responses to Urban Stimuli: A Balanced Approach.

    ERIC Educational Resources Information Center

    Geller, Daniel M.

    1980-01-01

    Proposes an alternative to Milgram's overload model of urban behavior. Suggests that intense, complex and/or novel stimuli may lead to positive as well as negative effects, and that this may vary across persons or over time. Presents data that confirm the importance of urban complexity as an organizing variable. (Author/GC)

  9. Contingent Stimuli Signal Subsequent Reinforcer Ratios

    ERIC Educational Resources Information Center

    Boutros, Nathalie; Davison, Michael; Elliffe, Douglas

    2011-01-01

    Conditioned reinforcer effects may be due to the stimulus' discriminative rather than its strengthening properties. While this was demonstrated in a frequently-changing choice procedure, a single attempt to replicate in a relatively static choice environment failed. We contend that this was because the information provided by the stimuli was…

  10. The BOSS Emission-Line Lens Survey (BELLS). I. A Large Spectroscopically Selected Sample of Lens Galaxies at Redshift ~0.5

    NASA Astrophysics Data System (ADS)

    Brownstein, Joel R.; Bolton, Adam S.; Schlegel, David J.; Eisenstein, Daniel J.; Kochanek, Christopher S.; Connolly, Natalia; Maraston, Claudia; Pandey, Parul; Seitz, Stella; Wake, David A.; Wood-Vasey, W. Michael; Brinkmann, Jon; Schneider, Donald P.; Weaver, Benjamin A.

    2012-01-01

    We present a catalog of 25 definite and 11 probable strong galaxy-galaxy gravitational lens systems with lens redshifts 0.4 <~ z <~ 0.7, discovered spectroscopically by the presence of higher-redshift emission lines within the Baryon Oscillation Spectroscopic Survey (BOSS) of luminous galaxies, and confirmed with high-resolution Hubble Space Telescope (HST) images of 44 candidates. Our survey extends the methodology of the Sloan Lens Advanced Camera for Surveys survey (SLACS) to higher redshift. We describe the details of the BOSS spectroscopic candidate detections, our HST ACS image processing and analysis methods, and our strong gravitational lens modeling procedure. We report BOSS spectroscopic parameters and ACS photometric parameters for all candidates, and mass-distribution parameters for the best-fit singular isothermal ellipsoid models of definite lenses. Our sample to date was selected using only the first six months of BOSS survey-quality spectroscopic data. The full five-year BOSS database should produce a sample of several hundred strong galaxy-galaxy lenses and in combination with SLACS lenses at lower redshift, strongly constrain the redshift evolution of the structure of elliptical, bulge-dominated galaxies as a function of luminosity, stellar mass, and rest-frame color, thereby providing a powerful test for competing theories of galaxy formation and evolution. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with program 12209. Based on spectroscopic data from the Baryon Oscillation Spectroscopic Survey of the Sloan Digital Sky Survey III.

  11. The temporal primacy of self-related stimuli and negative stimuli: an ERP-based comparative study.

    PubMed

    Zhu, Min; Luo, Junlong; Zhao, Na; Hu, Yinying; Yan, Lingyue; Gao, Xiangping

    2016-10-01

    Numerous studies have shown there exist attention biases for self-related and negative stimuli. Few studies, however, have been carried out to compare the effects of such stimuli on the neural mechanisms of early attentional alertness and subsequent cognitive processing. The purpose of the present study was to examine the temporal primacy of both self-related stimuli and negative stimuli in the neurophysiologic level. In a modified oddball task, event-related potentials of the deviant stimuli (i.e., self-face, negative face and neutral face) were recorded. Results revealed that larger P2 amplitudes were elicited by self-related and negative stimuli than by neutral stimuli. Negative stimuli, however, elicited shorter P2 latencies than self-related and neutral stimuli. As for the N2 component, self-related and negative stimuli elicited smaller amplitudes and shorter latencies than neutral stimuli, but otherwise did not differ. Self-related stimuli also elicited larger P3 and late positive component (LPC) amplitudes than negative and neutral stimuli. The pattern of results suggests that the primacy of negative stimuli occurred at an early attention stage of processing, while the primacy of self-related stimuli occurred at the subsequent cognitive evaluation and memory stage. PMID:26513485

  12. Preparation of stimuli for timbre perception studies.

    PubMed

    Labuschagne, Ilse B; Hanekom, Johan J

    2013-09-01

    Stimuli used in timbre perception studies must be controlled carefully in order to yield meaningful results. During psychoacoustic testing of individual timbre properties, (1) it must be ensured that timbre properties do not co-vary, as timbre properties are often not independent from one another, and (2) the potential influence of loudness, pitch, and perceived duration must be eliminated. A mathematical additive synthesis method is proposed which allows complete control over two spectral parameters, the spectral centroid (corresponding to brightness) and irregularity, and two temporal parameters, log rise-time (LRT) and a parameter characterizing the sustain/decay segment, while controlling for covariation in the spectral centroid and irregularity. Thirteen musical instrument sounds were synthesized. Perceptual data from six listeners indicate that variation in the four timbre properties mainly influences loudness and that perceived duration and pitch are not influenced significantly for the stimuli of longer duration (2 s) used here. Trends across instruments were found to be similar. PMID:23967955

  13. Physiological responses induced by pleasant stimuli.

    PubMed

    Watanuki, Shigeki; Kim, Yeon-Kyu

    2005-01-01

    The specific physiological responses induced by pleasant stimuli were investigated in this study. Various physiological responses of the brain (encephaloelectrogram; EEG), autonomic nervous system (ANS), immune system and endocrine system were monitored when pleasant stimuli such as odors, emotional pictures and rakugo, a typical Japanese comical story-telling, were presented to subjects. The results revealed that (i) EEG activities of the left frontal brain region were enhanced by a pleasant odor; (ii) emotional pictures related to primitive element such as nudes and erotic couples elevated vasomotor sympathetic nervous activity; and (iii) an increase in secretory immunoglobulin A (s-IgA) and a decrease in salivary cortisol (s-cortisol) were induced by rakugo-derived linguistic pleasant emotion. Pleasant emotion is complicated state. However, by considering the evolutionary history of human being, it is possible to assess and evaluate pleasant emotion from certain physiological responses by appropriately summating various physiological parameters. PMID:15684559

  14. The aperture problem in contoured stimuli

    PubMed Central

    Kane, David; Bex, Peter J.; Dakin, Steven C.

    2010-01-01

    A moving object elicits responses from V1 neurons tuned to a broad range of locations, directions, and spatiotemporal frequencies. Global pooling of such signals can overcome their intrinsic ambiguity in relation to the object’s direction/speed (the “aperture problem”); here we examine the role of low-spatial frequencies (SF) and second-order statistics in this process. Subjects made a 2AFC fine direction-discrimination judgement of ‘naturally’ contoured stimuli viewed rigidly translating behind a series of small circular apertures. This configuration allowed us to manipulate the scene in several ways; by randomly switching which portion of the stimulus was presented behind each aperture or by occluding certain spatial frequency bands. We report that global motion integration is (a) largely insensitive to the second-order statistics of such stimuli and (b) is rigidly broadband even in the presence of a disrupted low SF component. PMID:19810794

  15. Photonic water dynamically responsive to external stimuli.

    PubMed

    Sano, Koki; Kim, Youn Soo; Ishida, Yasuhiro; Ebina, Yasuo; Sasaki, Takayoshi; Hikima, Takaaki; Aida, Takuzo

    2016-01-01

    Fluids that contain ordered nanostructures with periodic distances in the visible-wavelength range, anomalously exhibit structural colours that can be rapidly modulated by external stimuli. Indeed, some fish can dynamically change colour by modulating the periodic distance of crystalline guanine sheets cofacially oriented in their fluid cytoplasm. Here we report that a dilute aqueous colloidal dispersion of negatively charged titanate nanosheets exhibits structural colours. In this 'photonic water', the nanosheets spontaneously adopt a cofacial geometry with an ultralong periodic distance of up to 675 nm due to a strong electrostatic repulsion. Consequently, the photonic water can even reflect near-infrared light up to 1,750 nm. The structural colour becomes more vivid in a magnetic flux that induces monodomain structural ordering of the colloidal dispersion. The reflective colour of the photonic water can be modulated over the entire visible region in response to appropriate physical or chemical stimuli. PMID:27572806

  16. Engineering nanomedicines using stimuli-responsive biomaterials

    PubMed Central

    Wang, Yapei; Byrne, James D.; Napier, Mary E.; DeSimone, Joseph M.

    2012-01-01

    The ability to engineer particles has the potential to shift the paradigm in the creation of new medicines and diagnostics. Complete control over particle characteristics, such as size, shape, mechanical property, and surface chemistry, can enable rapid translation and facilitate the US Food and Drug Administration (FDA) approval of particle technologies for the treatment of cancer, infectious diseases, diabetes, and a host of other major illnesses. The incorporation of natural and artificial external stimuli to trigger the release of drugs enables exquisite control over the release profiles of drugs in a given environment. In this article, we examine several readily scalable top-down methods for the fabrication of shape-specific particles that utilize stimuli-responsive biomaterials for controlled drug delivery. Special attention is given to Particle Replication In Nonwetting Templates (PRINT®) technology and the application of novel triggered-release synthetic and natural polymers. PMID:22266128

  17. Cortical gating of oropharyngeal sensory stimuli.

    PubMed

    Wheeler-Hegland, Karen; Pitts, Teresa; Davenport, Paul W

    2010-01-01

    Somatosensory evoked potentials provide a measure of cortical neuronal activation in response to various types of sensory stimuli. In order to prevent flooding of the cortex with redundant information various sensory stimuli are gated cortically such that response to stimulus 2 (S2) is significantly reduced in amplitude compared to stimulus 1 (S1). Upper airway protective mechanisms, such as swallowing and cough, are dependent on sensory input for triggering and modifying their motor output. Thus, it was hypothesized that central neural gating would be absent for paired-air puff stimuli applied to the oropharynx. Twenty-three healthy adults (18-35 years) served as research participants. Pharyngeal sensory evoked potentials (PSEPs) were measured via 32-electrode cap (10-20 system) connected to SynAmps(2) Neuroscan EEG System. Paired-pulse air puffs were delivered with an inter-stimulus interval of 500 ms to the oropharynx using a thin polyethylene tube connected to a flexible laryngoscope. Data were analyzed using descriptive statistics and a repeated measures analysis of variance. There were no significant differences found for the amplitudes S1 and S2 for any of the four component PSEP peaks. Mean gating ratios were above 0.90 for each peak. Results supports our hypothesis that sensory central neural gating would be absent for component PSEP peaks with paired-pulse stimuli delivered to the oropharynx. This may be related to the need for constant sensory monitoring necessary for adequate airway protection associated with swallowing and coughing. PMID:21423402

  18. Spatial Brightness Perception of Trichromatic Stimuli

    SciTech Connect

    Royer, Michael P.; Houser, Kevin W.

    2012-11-16

    An experiment was conducted to examine the effect of tuning optical radiation on brightness perception for younger (18-25 years of age) and older (50 years of age or older) observers. Participants made forced-choice evaluations of the brightness of a full factorial of stimulus pairs selected from two groups of four metameric stimuli. The large-field stimuli were created by systematically varying either the red or the blue primary of an RGB LED mixture. The results indicate that light stimuli of equal illuminance and chromaticity do not appear equally bright to either younger or older subjects. The rank-order of brightness is not predicted by any current model of human vision or theory of brightness perception including Scotopic to Photopic or Cirtopic to Photopic ratio theory, prime color theory, correlated color temperature, V(λ)-based photometry, color quality metrics, linear brightness models, or color appearance models. Age may affect brightness perception when short-wavelength primaries are used, especially those with a peak wavelength shorter than 450 nm. The results suggest further development of metrics to predict brightness perception is warranted, and that including age as a variable in predictive models may be valuable.

  19. Anagrus breviphragma Soyka Short Distance Search Stimuli

    PubMed Central

    Chiappini, Elisabetta; Berzolla, Alessia; Oppo, Annalisa

    2015-01-01

    Anagrus breviphragma Soyka (Hymenoptera: Mymaridae) successfully parasitises eggs of Cicadella viridis (L.) (Homoptera: Cicadellidae), embedded in vegetal tissues, suggesting the idea of possible chemical and physical cues, revealing the eggs presence. In this research, three treatments were considered in order to establish which types of cue are involved: eggs extracted from leaf, used as a control, eggs extracted from leaf and cleaned in water and ethanol, used to evaluate the presence of chemicals soluble in polar solvents, and eggs extracted from leaf and covered with Parafilm (M), used to avoid physical stimuli due to the bump on the leaf surface. The results show that eggs covered with Parafilm present a higher number of parasitised eggs and a lower probing starting time with respect to eggs washed with polar solvents or eggs extracted and untreated, both when the treatments were singly tested or when offered in sequence, independently of the treatment position. These results suggest that the exploited stimuli are not physical due to the bump but chemicals that can spread in the Parafilm, circulating the signal on the whole surface, and that the stimuli that elicit probing and oviposition are not subjected to learning. PMID:26543865

  20. Stimuli-responsive polymersomes for cancer therapy.

    PubMed

    Thambi, Thavasyappan; Park, Jae Hyung; Lee, Doo Sung

    2016-01-01

    Cancer is the leading cause of mortality and remains a major challenge for modern chemotherapy. Recent advances in cancer therapy have made a modest impact on patient survival. Nanomedicine represents an innovative field with significant potential to improve cancer treatment. Nanomedicine utilizes numerous nanoconstructs, including polymersomes, micelles, and drug conjugates, to deliver therapeutic agents at the target site of interest. In particular, polymeric vesicles, also known as polymersomes, are self-assembled amphiphilic polymers in which an aqueous compartment is enclosed by a thick bilayer membrane. Unlike liposomes, polymersomes consist of high-molecular-weight amphiphilic polymer analogues. Since polymersomes are prepared using synthetic amphiphilic polymers, the bilayer membrane thickness can be readily altered by tuning the molecular weight of hydrophobic blocks. As a consequence, the polymersomes prepared from high-molecular-weight amphiphiles strengthen their membranes, making them inherently more stable than liposomes. The intriguing aggregation of polymersomes offers numerous advantages, including stability, tunable membrane properties, and the capability of encapsulating hydrophilic and hydrophobic agents. Owing to these properties, polymersomes are attractive candidates for various applications such as drug delivery, gene therapy, and tissue engineering. Although these properties have placed polymersomes at the forefront of drug delivery applications, to attain an enhanced therapeutic effect polymersomes are supposed to rapidly release the drug at the target site. To fulfill this requirement, stimuli-responsive polymersomes that respond to various internal or external stimuli have been developed. This review focuses on recently developed stimuli-responsive polymersomes and their potential application in cancer therapy. PMID:26456625

  1. Visual stimuli recruit intrinsically generated cortical ensembles

    PubMed Central

    Miller, Jae-eun Kang; Ayzenshtat, Inbal; Carrillo-Reid, Luis; Yuste, Rafael

    2014-01-01

    The cortical microcircuit is built with recurrent excitatory connections, and it has long been suggested that the purpose of this design is to enable intrinsically driven reverberating activity. To understand the dynamics of neocortical intrinsic activity better, we performed two-photon calcium imaging of populations of neurons from the primary visual cortex of awake mice during visual stimulation and spontaneous activity. In both conditions, cortical activity is dominated by coactive groups of neurons, forming ensembles whose activation cannot be explained by the independent firing properties of their contributing neurons, considered in isolation. Moreover, individual neurons flexibly join multiple ensembles, vastly expanding the encoding potential of the circuit. Intriguingly, the same coactive ensembles can repeat spontaneously and in response to visual stimuli, indicating that stimulus-evoked responses arise from activating these intrinsic building blocks. Although the spatial properties of stimulus-driven and spontaneous ensembles are similar, spontaneous ensembles are active at random intervals, whereas visually evoked ensembles are time-locked to stimuli. We conclude that neuronal ensembles, built by the coactivation of flexible groups of neurons, are emergent functional units of cortical activity and propose that visual stimuli recruit intrinsically generated ensembles to represent visual attributes. PMID:25201983

  2. The BOSS Emission-line Lens Survey. III. Strong Lensing of Lyα Emitters by Individual Galaxies

    NASA Astrophysics Data System (ADS)

    Shu, Yiping; Bolton, Adam S.; Kochanek, Christopher S.; Oguri, Masamune; Pérez-Fournon, Ismael; Zheng, Zheng; Mao, Shude; Montero-Dorta, Antonio D.; Brownstein, Joel R.; Marques-Chaves, Rui; Ménard, Brice

    2016-06-01

    We introduce the Baryon Oscillation Spectroscopic Survey (BOSS) Emission-Line Lens Survey GALaxy-Lyα EmitteR sYstems (BELLS GALLERY) Survey, which is a Hubble Space Telescope program to image a sample of galaxy-scale strong gravitational lens candidate systems with high-redshift Lyα emitters (LAEs) as the background sources. The goal of the BELLS GALLERY Survey is to illuminate dark substructures in galaxy-scale halos by exploiting the small-scale clumpiness of rest-frame far-UV emission in lensed LAEs, and to thereby constrain the slope and normalization of the substructure-mass function. In this paper, we describe in detail the spectroscopic strong-lens selection technique, which is based on methods adopted in the previous Sloan Lens ACS (SLACS) Survey, BELLS, and SLACS for the Masses Survey. We present the BELLS GALLERY sample of the 21 highest-quality galaxy–LAE candidates selected from ≈ 1.4× {10}6 galaxy spectra in the BOSS of the Sloan Digital Sky Survey III. These systems consist of massive galaxies at redshifts of approximately 0.5 strongly lensing LAEs at redshifts from 2–3. The compact nature of LAEs makes them an ideal probe of dark substructures, with a substructure-mass sensitivity that is unprecedented in other optical strong-lens samples. The magnification effect from lensing will also reveal the structure of LAEs below 100 pc scales, providing a detailed look at the sites of the most concentrated unobscured star formation in the universe. The source code used for candidate selection is available for download as a part of this release.

  3. IGM CONSTRAINTS FROM THE SDSS-III/BOSS DR9 Lyα FOREST TRANSMISSION PROBABILITY DISTRIBUTION FUNCTION

    SciTech Connect

    Lee, Khee-Gan; Hennawi, Joseph F.; Spergel, David N.; Weinberg, David H.; Hogg, David W.; Viel, Matteo; Bolton, James S.; Bailey, Stephen; Carithers, William; Schlegel, David J.; Pieri, Matthew M.; Lundgren, Britt; Palanque-Delabrouille, Nathalie; Yèche, Christophe; Schneider, Donald P.

    2015-02-01

    The Lyα forest transmission probability distribution function (PDF) is an established probe of the intergalactic medium (IGM) astrophysics, especially the temperature-density relationship of the IGM. We measure the transmission PDF from 3393 Baryon Oscillations Spectroscopic Survey (BOSS) quasars from Sloan Digital Sky Survey Data Release 9, and compare with mock spectra that include careful modeling of the noise, continuum, and astrophysical uncertainties. The BOSS transmission PDFs, measured at (z) = [2.3, 2.6, 3.0], are compared with PDFs created from mock spectra drawn from a suite of hydrodynamical simulations that sample the IGM temperature-density relationship, γ, and temperature at mean density, T {sub 0}, where T(Δ) = T {sub 0}Δ{sup γ} {sup –} {sup 1}. We find that a significant population of partial Lyman-limit systems (LLSs) with a column-density distribution slope of β{sub pLLS} ∼ – 2 are required to explain the data at the low-transmission end of transmission PDF, while uncertainties in the mean Lyα forest transmission affect the high-transmission end. After modeling the LLSs and marginalizing over mean transmission uncertainties, we find that γ = 1.6 best describes the data over our entire redshift range, although constraints on T {sub 0} are affected by systematic uncertainties. Within our model framework, isothermal or inverted temperature-density relationships (γ ≤ 1) are disfavored at a significance of over 4σ, although this could be somewhat weakened by cosmological and astrophysical uncertainties that we did not model.

  4. The BOSS: a novel approach to coupling temporal changes in geochemistry and microbiology in the deep subsurface biosphere.

    NASA Astrophysics Data System (ADS)

    Girguis, P. R.; Robidart, J.; Wheat, G.

    2008-12-01

    Though our knowledge of deep subsurface environments is burgeoning, our understanding of the physiological capacity and activity of deep subsurface microbial communities is in its infancy. Specifically, the quantitative relationship between microbial diversity, density, and activity and geochemical cycles is poorly understood, as is true for most marine environments. This is due to the difficulty of concurrently sampling and quantifying both biological and chemical factors over time and space, especially in remote or inhospitable locales. To address this limitation, we have developed a BioOsmoSampling System (or BOSS). Osmosamplers use osmotic pressure to continuously sample seawater, and can be deployed on the order of weeks to years. These osmosamplers have been previously used for geochemical sampling, and we have developed the hardware and reagents to enable their use in microbial sampling. In particular, we have developed the capacity to collect and preserve fluid samples for nucleic acid and protein analyses, as well as lipids and cellular structure (for microscopy). Molecular degradation in a variety of preservatives was <50% (DNA) and <15% (proteins, lipids) after one year, and ongoing efforts suggest that three-year preservation of DNA and proteins is possible. Here we present data from a pilot study, in which we deployed the BOSS at a diffuse flow vent site at the Juan de Fuca Ridge, and an IODP borehole in Middle Valley. We observed co- registered changes in geochemistry (both ions and volatiles), temperature and microbial community composition. We also recovered high densities of previously enigmatic microbes. This proof-of-concept experiment allowed us to correlate changes in microbial population structure with changes in the physicochemical environment in the diffuse hydrothermal flow, and set the stage for future deep subsurface deployments.

  5. The Facilitative Effect of Positive Stimuli on 3-Year-Olds' Flexible Rule Use

    ERIC Educational Resources Information Center

    Qu, Li; Zelazo, Philip David

    2007-01-01

    This study examined the effect of emotional stimuli on 3- to 4-year old children's flexible rule use, as measured by the Dimensional Change Card Sort (DCCS). In Experiment 1, children in two countries (Canada and China) were given 2 versions of the DCCS. The Standard version required children to sort red and blue boats and rabbits first by shape…

  6. The visual mismatch negativity elicited with visual speech stimuli

    PubMed Central

    Files, Benjamin T.; Auer, Edward T.; Bernstein, Lynne E.

    2013-01-01

    The visual mismatch negativity (vMMN), deriving from the brain's response to stimulus deviance, is thought to be generated by the cortex that represents the stimulus. The vMMN response to visual speech stimuli was used in a study of the lateralization of visual speech processing. Previous research suggested that the right posterior temporal cortex has specialization for processing simple non-speech face gestures, and the left posterior temporal cortex has specialization for processing visual speech gestures. Here, visual speech consonant-vowel (CV) stimuli with controlled perceptual dissimilarities were presented in an electroencephalography (EEG) vMMN paradigm. The vMMNs were obtained using the comparison of event-related potentials (ERPs) for separate CVs in their roles as deviant vs. their roles as standard. Four separate vMMN contrasts were tested, two with the perceptually far deviants (i.e., “zha” or “fa”) and two with the near deviants (i.e., “zha” or “ta”). Only far deviants evoked the vMMN response over the left posterior temporal cortex. All four deviants evoked vMMNs over the right posterior temporal cortex. The results are interpreted as evidence that the left posterior temporal cortex represents speech contrasts that are perceived as different consonants, and the right posterior temporal cortex represents face gestures that may not be perceived as different CVs. PMID:23882205

  7. Dorsal horn spatial representation of simple cutaneous stimuli.

    PubMed

    Brown, P B; Millecchia, R; Lawson, J J; Stephens, S; Harton, P; Culberson, J C

    1998-02-01

    A model of lamina III-IV dorsal horn cell receptive fields (RFs) has been developed to visualize the spatial patterns of cells activated by light touch stimuli. Low-threshold mechanoreceptive fields (RFs) of 551 dorsal horn neurons recorded in anesthetized cats were characterized by location of RF center in cylindrical coordinates, area, length/width ratio, and orientation of long axis. Best-fitting ellipses overlapped actual RFs by 90%. Exponentially smoothed mean and variance surfaces were estimated for these five variables, on a grid of 40 points mediolaterally by 20/segment rostrocaudally in dorsal horn segments L4-S1. The variations of model RF location, area, and length/width ratio with map location were all similar to previous observations. When elliptical RFs were simulated at the locations of the original cells, the RFs of real and simulated cells overlapped by 64%. The densities of cell representations of skin points on the hindlimb were represented as pseudocolor contour plots on dorsal view maps, and segmental representations were plotted on the standard views of the leg. Overlap of modeled and real segmental representations was at the 84% level. Simulated and observed RFs had similar relations between area and length/width ratio and location on the hindlimb: r(A) = 0.52; r(L/W) = 0.56. Although the representation of simple stimuli was orderly, and there was clearly only one somatotopic map of the skin, the representation of a single point often was not a single cluster of active neurons. When two-point stimuli were simulated, there usually was no fractionation of response zones or addition of new zones. Variation of stimulus size (area of skin contacted) produced less variation of representation size (number of cells responding) than movement of stimuli from one location to another. We conclude that stimulus features are preserved poorly in their dorsal horn spatial representation and that discrimination mechanisms that depend on detection of such

  8. Wind turbine acoustic standards

    NASA Technical Reports Server (NTRS)

    Stephens, D. G.; Shepherd, K. P.; Grosveld, F.

    1981-01-01

    A program is being conducted to develop noise standards for wind turbines which minimize annoyance and which can be used to design specifications. The approach consists of presenting wind turbine noise stimuli to test subjects in a laboratory listening chamber. The responses of the subjects are recorded for a range of stimuli which encompass the designs, operating conditions, and ambient noise levels of current and future installations. Results to date have established the threshold of detectability for a range of impulsive stimuli of the type associated with blade/tower wake interactions. The status of the ongoing psychoacoustic tests, the subjective data, and the approach to the development of acoustic criteria/standards are described.

  9. Olfactory Stimuli Increase Presence in Virtual Environments

    PubMed Central

    Munyan, Benson G.; Neer, Sandra M.; Beidel, Deborah C.; Jentsch, Florian

    2016-01-01

    Background Exposure therapy (EXP) is the most empirically supported treatment for anxiety and trauma-related disorders. EXP consists of repeated exposure to a feared object or situation in the absence of the feared outcome in order to extinguish associated anxiety. Key to the success of EXP is the need to present the feared object/event/situation in as much detail and utilizing as many sensory modalities as possible, in order to augment the sense of presence during exposure sessions. Various technologies used to augment the exposure therapy process by presenting multi-sensory cues (e.g., sights, smells, sounds). Studies have shown that scents can elicit emotionally charged memories, but no prior research has examined the effect of olfactory stimuli upon the patient’s sense of presence during simulated exposure tasks. Methods 60 adult participants navigated a mildly anxiety-producing virtual environment (VE) similar to those used in the treatment of anxiety disorders. Participants had no autobiographical memory associated with the VE. State anxiety, Presence ratings, and electrodermal (EDA) activity were collected throughout the experiment. Results Utilizing a Bonferroni corrected Linear Mixed Model, our results showed statistically significant relationships between olfactory stimuli and presence as assessed by both the Igroup Presence Questionnaire (IPQ: R2 = 0.85, (F(3,52) = 6.625, p = 0.0007) and a single item visual-analogue scale (R2 = 0.85, (F(3,52) = 5.382, p = 0.0027). State anxiety was unaffected by the presence or absence of olfactory cues. EDA was unaffected by experimental condition. Conclusion Olfactory stimuli increase presence in virtual environments that approximate those typical in exposure therapy, but did not increase EDA. Additionally, once administered, the removal of scents resulted in a disproportionate decrease in presence. Implications for incorporating the use of scents to increase the efficacy of exposure therapy is discussed. PMID

  10. Stimuli-responsive chromism in organophosphorus chemistry.

    PubMed

    Reus, Christian; Baumgartner, Thomas

    2016-02-01

    Changes in color are one of the most obvious and easily followed responses that can be induced by an external stimulus. π-Conjugated organophosphorus compounds are on the rise to challenge established systems by opening up new and simple pathways to diversely modified optoelectronic properties--the main challenge for the development of new chromic materials. Relevant stimuli highlighted in this Frontier article include electronic current (electrochromism), light (photochromism), solvent polarity (solvatochromism), aggregation formation (aggregation induced emission, AIE), mechanical force (mechanochromism), temperature (thermochromism), organic solvent vapor (vapochromism), and pH (halochromism). PMID:26286166

  11. An online brain-computer interface based on shifting attention to concurrent streams of auditory stimuli

    NASA Astrophysics Data System (ADS)

    Hill, N. J.; Schölkopf, B.

    2012-04-01

    We report on the development and online testing of an electroencephalogram-based brain-computer interface (BCI) that aims to be usable by completely paralysed users—for whom visual or motor-system-based BCIs may not be suitable, and among whom reports of successful BCI use have so far been very rare. The current approach exploits covert shifts of attention to auditory stimuli in a dichotic-listening stimulus design. To compare the efficacy of event-related potentials (ERPs) and steady-state auditory evoked potentials (SSAEPs), the stimuli were designed such that they elicited both ERPs and SSAEPs simultaneously. Trial-by-trial feedback was provided online, based on subjects' modulation of N1 and P3 ERP components measured during single 5 s stimulation intervals. All 13 healthy subjects were able to use the BCI, with performance in a binary left/right choice task ranging from 75% to 96% correct across subjects (mean 85%). BCI classification was based on the contrast between stimuli in the attended stream and stimuli in the unattended stream, making use of every stimulus, rather than contrasting frequent standard and rare ‘oddball’ stimuli. SSAEPs were assessed offline: for all subjects, spectral components at the two exactly known modulation frequencies allowed discrimination of pre-stimulus from stimulus intervals, and of left-only stimuli from right-only stimuli when one side of the dichotic stimulus pair was muted. However, attention modulation of SSAEPs was not sufficient for single-trial BCI communication, even when the subject's attention was clearly focused well enough to allow classification of the same trials via ERPs. ERPs clearly provided a superior basis for BCI. The ERP results are a promising step towards the development of a simple-to-use, reliable yes/no communication system for users in the most severely paralysed states, as well as potential attention-monitoring and -training applications outside the context of assistive technology.

  12. Stimuli-Responsive Nanomaterials for Biomedical Applications

    PubMed Central

    2015-01-01

    Nature employs a variety of tactics to precisely time and execute the processes and mechanics of life, relying on sequential sense and response cascades to transduce signaling events over multiple length and time scales. Many of these tactics, such as the activation of a zymogen, involve the direct manipulation of a material by a stimulus. Similarly, effective therapeutics and diagnostics require the selective and efficient homing of material to specific tissues and biomolecular targets with appropriate temporal resolution. These systems must also avoid undesirable or toxic side effects and evade unwanted removal by endogenous clearing mechanisms. Nanoscale delivery vehicles have been developed to package materials with the hope of delivering them to select locations with rates of accumulation and clearance governed by an interplay between the carrier and its cargo. Many modern approaches to drug delivery have taken inspiration from natural activatable materials like zymogens, membrane proteins, and metabolites, whereby stimuli initiate transformations that are required for cargo release, prodrug activation, or selective transport. This Perspective describes key advances in the field of stimuli-responsive nanomaterials while highlighting some of the many challenges faced and opportunities for development. Major hurdles include the increasing need for powerful new tools and strategies for characterizing the dynamics, morphology, and behavior of advanced delivery systems in situ and the perennial problem of identifying truly specific and useful physical or molecular biomarkers that allow a material to autonomously distinguish diseased from normal tissue. PMID:25474531

  13. Remindings influence the interpretation of ambiguous stimuli.

    PubMed

    Tullis, Jonathan G; Braverman, Michael; Ross, Brian H; Benjamin, Aaron S

    2014-02-01

    Remindings-stimulus-guided retrievals of prior events-may help us interpret ambiguous events by linking the current situation to relevant prior experiences. Evidence suggests that remindings play an important role in interpreting complex ambiguous stimuli (Ross & Bradshaw Memory & Cognition, 22, 591-605, 1994); here, we evaluate whether remindings will influence word interpretation and memory in a new paradigm. Learners studied words on distinct visual backgrounds and generated a sentence for each word. Homographs were preceded by a biasing cue on the same background three items earlier, preceded by a biasing cue on a different background three items earlier, or followed by a biasing cue on the same background three items later. When biasing cues preceded the homographs on the same backgrounds as the homographs, the meanings of the homographs in learner-generated sentences were consistent with the biasing cues more often than in the other two conditions. These results show that remindings can influence word interpretation. In addition, later memory for the homographs and cues was greater when the meaning of the homograph in the sentence was consistent with the earlier biasing cue, suggesting that remindings enhanced mnemonic performance. Remindings play an important role in how we interpret ambiguous stimuli and enhance memory for the involved material. PMID:23835617

  14. Continuum Models of Stimuli-responsive Gels

    NASA Astrophysics Data System (ADS)

    Hong, Wei

    Immersed in a solution of small molecules and ions, a network of long-chain polymers may imbibe the solution and swell, resulting in a polymeric gel. Depending on the molecular structure of the polymers, the amount of swelling can be regulated by moisture, mechanical forces, ionic strength, electric field, pH value, and many other types of stimuli. Starting from the basic principles of non-equilibrium thermodynamics, this chapter formulates a field theory of the coupled large deformation and mass transportation in a neutral polymeric gel. The theory is then extended to study polyelectrolyte gels with charge-carrying networks by accounting for the electromechanical coupling and migration of solute ions. While the theoretical framework is adaptable to various types of material models, some representative ones are described through specific free-energy functions and kinetic laws. A specific material law for pH-sensitive gels—a special type of polyelectrolyte gels—is introduced as an example of incorporating chemical reactions in modeling stimuli-responsive gels. Finally, a simplified theory for the equilibrium but inhomogeneous swelling of a polymeric gel is deduced. The theory and the specific material models are illustrated through several examples.

  15. Influence of different mechanical stimuli in a multi-scale mechanobiological isotropic model for bone remodelling.

    PubMed

    Mercuri, E G F; Daniel, A L; Hecke, M B; Carvalho, L

    2016-09-01

    This work represents a study of a mathematical model that describes the biological response to different mechanical stimuli in a cellular dynamics model for bone remodelling. The biological system discussed herein consists of three specialised cellular types, responsive osteoblasts, active osteoblasts and osteoclasts, three types of signalling molecules, transforming growth factor beta (TGF-β), receptor activator of nuclear factor kappa-b ligand (RANKL) and osteoprotegerin (OPG) and the parathyroid hormone (PTH). Three proposals for mechanical stimuli were tested: strain energy density (SED), hydrostatic and deviatoric parts of SED. The model was tested in a two-dimensional geometry of a standard human femur. The spatial discretization was performed by the finite element method while the temporal evolution of the variables was calculated by the 4th order Runge-Kutta method. The obtained results represent the temporal evolution of the apparent density distribution and the mean apparent density and thickness for the cortical bone after 600 days of remodelling simulation. The main contributions of this paper are the coupling of mechanical and biological models and the exploration of how the different mechanical stimuli affect the cellular activity in different types of physical activities. The results revealed that hydrostatic SED stimulus was able to form more cortical bone than deviatoric SED and total SED stimuli. The computational model confirms how different mechanical stimuli can impact in the balance of bone homeostasis. PMID:27215171

  16. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: mock galaxy catalogues for the BOSS Final Data Release

    NASA Astrophysics Data System (ADS)

    Kitaura, Francisco-Shu; Rodríguez-Torres, Sergio; Chuang, Chia-Hsun; Zhao, Cheng; Prada, Francisco; Gil-Marín, Héctor; Guo, Hong; Yepes, Gustavo; Klypin, Anatoly; Scóccola, Claudia G.; Tinker, Jeremy; McBride, Cameron; Reid, Beth; Sánchez, Ariel G.; Salazar-Albornoz, Salvador; Grieb, Jan Niklas; Vargas-Magana, Mariana; Cuesta, Antonio J.; Neyrinck, Mark; Beutler, Florian; Comparat, Johan; Percival, Will J.; Ross, Ashley

    2016-03-01

    We reproduce the galaxy clustering catalogue from the SDSS-III Baryon Oscillation Spectroscopic Survey Final Data Release (BOSS DR11&DR12) with high fidelity on all relevant scales in order to allow a robust analysis of baryon acoustic oscillations and redshift space distortions. We have generated (6000) 12 288 MultiDark PATCHY BOSS (DR11) DR12 light cones corresponding to an effective volume of ˜192 000 [h-1 Gpc]3 (the largest ever simulated volume), including cosmic evolution in the redshift range from 0.15 to 0.75. The mocks have been calibrated using a reference galaxy catalogue based on the halo abundance matching modelling of the BOSS DR11&DR12 galaxy clustering data and on the data themselves. The production follows three steps. First, we apply the PATCHY code to generate a dark matter field and an object distribution including non-linear stochastic galaxy bias. Secondly, we run the halo/stellar distribution reconstruction HADRON code to assign masses to the various objects. This step uses the mass distribution as a function of local density and non-local indicators (i.e. tidal field tensor eigenvalues and relative halo exclusion separation for massive objects) from the reference simulation applied to the corresponding patchy dark matter and galaxy distribution. Finally, we apply the SUGAR code to build the light cones. The resulting MultiDarkPATCHY mock light cones reproduce the number density, selection function, survey geometry, and in general within 1σ, for arbitrary stellar mass bins, the power spectrum up to k = 0.3 h Mpc-1, the two-point correlation functions down to a few Mpc scales, and the three-point statistics of the BOSS DR11&DR12 galaxy samples.

  17. MULTIFUNCTIONAL AND STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS

    PubMed Central

    Torchilin, Vladimir

    2011-01-01

    Currently used pharmaceutical nanocarriers, such as liposomes, micelles, and polymeric nanoparticles, demonstrate a broad variety of useful properties, such as longevity in the body; specific targeting to certain disease sites; enhanced intracellular penetration; contrast properties allowing for direct carrier visualization in vivo; stimili-sensitivity, and others. Some of those pharmaceutical carriers have already made their way into clinic, while others are still under preclinical development. In certain cases, the pharmaceutical nanocarriers combine several of the listed properties. Long-circulating immunoliposomes capable of prolonged residence in the blood and specific target recognition represent one of examples of this kind. The engineering of multifunctional pharmaceutical nanocarriers combining several useful properties in one particle can significantly enhance the efficacy of many therapeutic and diagnostic protocols. This paper considers the current status and possible future directions in the emerging area of multifunctional nanocarriers with primary attention on the combination of such properties as longevity, targetability, intracellular penetration, contrast loading, and stimuli sensitivity. PMID:18977297

  18. Stimuli dependent impedance of conductive magnetorheological elastomers

    NASA Astrophysics Data System (ADS)

    Wang, Yu; Xuan, Shouhu; Dong, Bo; Xu, Feng; Gong, Xinglong

    2016-02-01

    The structure dependent impedance of conductive magnetorheological elastomers (MREs) under different loads and magnetic fields has been studied in this work. By increasing the weight fraction of iron particles, the conductivity of the MREs increased. Dynamic mechanical measurements and synchrotron radiation x-ray computed tomography (SR-CT) were used and they provided reasons for the electrical properties changing significantly under pressure and magnetic field stimulation. The high sensitivity of MREs to external stimuli renders them suitable for application in force or magnetic field sensors. The equivalent circuit model was proposed to analyze the impedance response of MREs and it fits the experimental results very well. Each circuit component reflected the change of the inner interface under different conditions, thus relative changes in the microstructure could be distinguished. This method could be used not only to detect the structural changes in the MRE but also to provide a great deal of valuable information for the further understanding of the MR mechanism.

  19. Nanoporous frameworks exhibiting multiple stimuli responsiveness

    NASA Astrophysics Data System (ADS)

    Kundu, Pintu K.; Olsen, Gregory L.; Kiss, Vladimir; Klajn, Rafal

    2014-04-01

    Nanoporous frameworks are polymeric materials built from rigid molecules, which give rise to their nanoporous structures with applications in gas sorption and storage, catalysis and others. Conceptually new applications could emerge, should these beneficial properties be manipulated by external stimuli in a reversible manner. One approach to render nanoporous frameworks responsive to external signals would be to immobilize molecular switches within their nanopores. Although the majority of molecular switches require conformational freedom to isomerize, and switching in the solid state is prohibited, the nanopores may provide enough room for the switches to efficiently isomerize. Here we describe two families of nanoporous materials incorporating the spiropyran molecular switch. These materials exhibit a variety of interesting properties, including reversible photochromism and acidochromism under solvent-free conditions, light-controlled capture and release of metal ions, as well reversible chromism induced by solvation/desolvation.

  20. Visual reflex seizures induced by complex stimuli.

    PubMed

    Zifkin, Benjamin G; Inoue, Yushi

    2004-01-01

    Visual reflex seizures induced by complex stimuli may be triggered by patterned and flashing displays that are now ubiquitous. The seizures may be clinically generalized, but unilateral and bilateral myoclonic attacks also may be triggered, especially in patients with juvenile myoclonic epilepsy, and recently, clearly focal reflex occipital lobe seizures have been described. Some seizure-triggering properties of video displays can be identified, such as perceived brightness, pattern, flicker frequency, and color. Knowledge of these is useful in planning individual treatment and in designing regulations for screen content of television broadcasts or for other video displays. Some subjects will also be sensitive to cognitive or action-programming activation, especially when playing video games, and this can increase the chance of seizure triggering. Nonspecific factors such as sleep deprivation, prolonged exposure, and drug or alcohol use also may play a role in reflex seizure occurrence. PMID:14706042

  1. Working memory of emotional stimuli: Electrophysiological characterization.

    PubMed

    Kessel, Dominique; García-Rubio, María J; González, E Kirstin; Tapia, Manuel; López-Martín, Sara; Román, Francisco J; Capilla, Almudena; Martínez, Kenia; Colom, Roberto; Carretié, Luis

    2016-09-01

    Memorizing emotional stimuli in a preferential way seems to be one of the adaptive strategies brought on by evolution for supporting survival. However, there is a lack of electrophysiological evidence on this bias in working memory. The present study analyzed the influence of emotion on the updating component of working memory. Behavioral and electrophysiological indices were measured from a 3-back task using negative, neutral, and positive faces. Electrophysiological data evidenced an emotional influence on the working memory sensitive P3 component, which presented larger amplitudes for negative matching faces compared to neutral ones. This effect originated in the superior parietal cortex, previously reported to be involved in N-back tasks. Additionally, P3 results showed a correlation with reaction times, where higher amplitudes were associated with faster responses for negative matching faces. These findings indicate that electrophysiological measures seem to be very suitable indices of the emotional influence on working memory. PMID:27402441

  2. Seeing the Lyman-Alpha Forest for the Trees: Constraints on the Thermal State of the IGM from SDSS-III/BOSS

    NASA Astrophysics Data System (ADS)

    Lee, Khee-Gan

    The Lyman-alpha (Lya) forest in the line-of-sight to distant quasars is an important probe of the intergalactic medium (IGM). The thermal properties of the IGM can provide insight the reionization history of the universe, as well as indirectly constraining energy sources in the universe such as galaxies and quasars. This thesis is concerned primarily with studying the IGM using moderate quality Lya forest data sets from large-scale spectroscopic surveys, such as the Sloan Digital Sky Survey (SDSS) and the Baryon Oscillations Spectroscopic Survey (BOSS). In Chapter 1, we study the potential of SDSS Lya forest data to study the IGM. Using simulated mock spectra, we show that the flux probability distribution function (PDF) of SDSS data can place interesting constraints on the spatially-averaged temperature-density relation (TDR) of the IGM. We also introduce the threshold probability functions, a one-dimensional two-point statistic adapted from material sciences that can be applied to SDSS data to detect ˜ 50 Mpc IGM thermal inhomogeneities arising from He II reionization. Chapter 2 discusses the effect of continuum biases in the TDR measured from high-resolution Lyalpha forest spectra in the context of recent evidence for an inverted (gamma < 1) TDR. We argue that forward modeling of continuum errors in mock spectra are necessary to make robust estimates of the TDR. Motivated by the importance of accurate continuum estimation in Lya forest analysis, Chapter 3 introduces the mean-flux regulated/principal component analysis (MF-PCA) continuum estimation technique. We show using mock spectra that this technique can achieve continuum accuracies of < 10% and < 4% in noisy spectra of S/N ˜ 2 and S/N ˜ 5, respectively. We have also publicly released ˜ 13,000 continua from SDSS Data Release 7. In Chapter 4, we measure the flux PDF from BOSS, drawing from an overall sample of ˜ 30,000 Lya forest sightlines. This uses a novel procedure for optimally combining the

  3. Memory of Germinant Stimuli in Bacterial Spores

    PubMed Central

    Wang, Shiwei; Faeder, James R.; Setlow, Peter

    2015-01-01

    ABSTRACT Bacterial spores, despite being metabolically dormant, possess the remarkable capacity to detect nutrients and other molecules in their environment through a biochemical sensory apparatus that can trigger spore germination, allowing the return to vegetative growth within minutes of exposure of germinants. We demonstrate here that bacterial spores of multiple species retain memory of transient exposures to germinant stimuli that can result in altered responses to subsequent exposure. The magnitude and decay of these memory effects depend on the pulse duration as well as on the separation time, incubation temperature, and pH values between the pulses. Spores of Bacillus species germinate in response to nutrients that interact with germinant receptors (GRs) in the spore’s inner membrane, with different nutrient types acting on different receptors. In our experiments, B. subtilis spores display memory when the first and second germinant pulses target different receptors, suggesting that some components of spore memory are downstream of GRs. Furthermore, nonnutrient germinants, which do not require GRs, exhibit memory either alone or in combination with nutrient germinants, and memory of nonnutrient stimulation is found to be more persistent than that induced by GR-dependent stimuli. Spores of B. cereus and Clostridium difficile also exhibit germination memory, suggesting that memory may be a general property of bacterial spores. These observations along with experiments involving strains with mutations in various germination proteins suggest a model in which memory is stored primarily in the metastable states of SpoVA proteins, which comprise a channel for release of dipicolinic acid, a major early event in spore germination. PMID:26604257

  4. Connecting Massive Galaxies to Dark Matter Halos in BOSS. I: Is Galaxy Color a Stochastic Process in High Mass Halos?

    NASA Astrophysics Data System (ADS)

    Saito, Shun; Leauthaud, Alexie; Hearin, Andrew P.; Bundy, Kevin; Zentner, Andrew R.; Behroozi, Peter S.; Reid, Beth A.; Sinha, Manodeep; Coupon, Jean; Tinker, Jeremy L.; White, Martin; Schneider, Donald P.

    2016-05-01

    We use subhalo abundance matching (SHAM) to model the stellar mass function (SMF) and clustering of the Baryon Oscillation Spectroscopic Survey (BOSS) "CMASS" sample at z ˜ 0.5. We introduce a novel method which accounts for the stellar mass incompleteness of CMASS as a function of redshift, and produce CMASS mock catalogs which include selection effects, reproduce the overall SMF, the projected two-point correlation function wp, the CMASS dn/dz, and are made publicly available. We study the effects of assembly bias above collapse mass in the context of "age matching" and show that these effects are markedly different compared to the ones explored by Hearin et al. (2013) at lower stellar masses. We construct two models, one in which galaxy color is stochastic ("AbM" model) as well as a model which contains assembly bias effects ("AgM" model). By confronting the redshift dependent clustering of CMASS with the predictions from our model, we argue that that galaxy colors are not a stochastic process in high-mass halos. Our results suggest that the colors of galaxies in high-mass halos are determined by other halo properties besides halo peak velocity and that assembly bias effects play an important role in determining the clustering properties of this sample.

  5. ANSI/AIAA S-081A, Pressure Vessel Standards Implementation Guidelines

    NASA Technical Reports Server (NTRS)

    Greene, Nathanael J.

    2009-01-01

    The stress rupture specification for Composite Overwrapped Pressure Vessels (COPV) is discussed. The composite shell of the COPV shall be designed to meet the design life considering the time it is under sustained load. A Mechcanical Damage Control Plan (MDCP) shall be created and implemented that assures the COPV will not fail due to mechanical damage due to manufacturing, testing, shipping, installation, or flight. Proven processes and procedures for fabrication and repair shall be used to preclude damage or material degradation during material processing, manufacturing operations, and refurbushment.Selected NDI techniques for the liner and/or boss(es) shall be performed before overwrapping with composite. When visual inspection reveals mechanical damage or defects exceeding manufacturing specification levels (and standard repair procedures), the damaged COPV shall be submitted to a material review board (MRB) for disposition. Every COPV shall be subjected to visual and other non-destructive inspection (NDI), per the inspection plan.

  6. Gating of attention towards food stimuli in binge eating disorder.

    PubMed

    Schmitz, Florian; Naumann, Eva; Biehl, Stefanie; Svaldi, Jennifer

    2015-12-01

    Cognitive models of eating disorders propose that attentional biases for disorder-relevant stimuli contribute to eating disorder pathology. Empirical evidence of a contribution of attentional biases for binge eating disorder (BED) is still scarce. The aim of the present study was to assess attention engagement towards, and disengagement from, food stimuli in overweight females with BED (n = 25) and a group of overweight and obese women without BED (OW; n = 30). Participants completed a rapid serial visual presentation (RSVP) paradigm with food and neutral words as target stimuli. This task can be used to decompose an attentional bias for food stimuli into its stimulus engagement and stimulus disengagement components. Findings indicate that facilitated stimulus engagement for food stimuli over neutral stimuli was more pronounced in the BED group compared to the OW group. Conversely, there were no substantial disengagement effects in either group. Thereby, results support the idea that early attentional processes are biased in BED. PMID:26212270

  7. Cognitive evoked potentials to speech and tonal stimuli in children with implants.

    PubMed

    Kileny, P R; Boerst, A; Zwolan, T

    1997-09-01

    We investigated late and cognitive (mismatch negativity, P300) auditory potentials in 14 children with cochlear implants between the ages of 4 and 12 years. Length of cochlear implant use ranged from 7 to 84 months. Three types of stimulus contrasts were used: (1) a loudness contrast consisting of a 1500 Hz tone burst presented at 75 (standard) and 90 dB sound pressure level (deviant); (2) a frequency contrast consisting of a 1500 Hz tone burst (standard) and a 3000 Hz tone burst (deviant) presented at 80 dB sound pressure level; and (3) a speech contrast consisting of "heed" (standard) and "who'd" (deviant) delivered with a roving loudness paradigm involving a randomized variation of the levels of the standard and deviant stimuli. Latencies and amplitudes of components N1, P2, N2, and P3 and a mismatch negativity were measured. Overall, there were very few missing or unidentifiable components. P3 and mismatch negativity components were identified for all subjects and all stimuli. The latencies of most components were affected by stimulus type. There was a trend for longer latencies for the speech contrast compared with the loudness or frequency contrasts. This may be a reflection of the increased processing time required for the speech stimuli because of its higher complexity. There were several significant correlations between speech recognition and cognitive evoked potential latencies. These results indicate that the clinical use of cognitive evoked potentials in children with cochlear implants is feasible and informative. PMID:9334760

  8. The influence of stimulus repetition on duration judgments with simple stimuli

    PubMed Central

    Birngruber, Teresa; Schröter, Hannes; Ulrich, Rolf

    2015-01-01

    Two experiments investigated the effects of stimulus repetition vs. stimulus novelty on perceived duration. In a reminder task, a standard and a comparison stimulus were presented consecutively in each trial, and the comparison was either a repetition of the standard or a different stimulus. Pseudowords (Experiment 1) or strings of consonants (Experiment 2) were used as stimuli and the inter-stimulus interval (ISI) between the standard and the comparison was either constant or variable. Participants were asked to judge whether the comparison was shorter or longer than the standard. In both experiments, we observed shorter judged durations for repeated than for novel comparisons whereas the manipulation of the ISI had no pronounced effects on duration judgments. The finding of shorter duration judgments for repeated as compared to novel nonwords replicates the results of a previous study (Matthews, 2011) which employed highly complex stimulus material. The present study shows that changes of simple, semantically meaningless stimuli are sufficient to result in a shorter perceived duration of repeated as compared to novel stimuli. PMID:26347682

  9. EFFECT OF POSITIVE AND NEGATIVE AFFECTIVE STIMULI AND BEVERAGE CUES ON MEASURES OF CRAVING IN NON TREATMENT-SEEKING ALCOHOLICS

    PubMed Central

    Mason, Barbara J.; Light, John M.; Escher, Tobie; Drobes, David J.

    2009-01-01

    Rationale Laboratory paradigms are useful for investigating mechanisms of human alcohol cue reactivity in a highly controlled environment. A number of studies have examined the effects of beverage exposure or negative affective stimuli on cue reactivity independently, but only a few have reported on interaction effects between beverage cue and affective stimuli, and none have evaluated the effects of positive stimuli on beverage cue reactivity. Objectives To assess independent and interactive effects of both positive and negative affective stimuli and beverage cue on psychophysiological and subjective measures of reactivity in alcohol dependence. Methods A total of 47 non treatment-seeking paid volunteers with current alcohol dependence participated in a within-subjects trial where each was exposed to a standardized set of pleasant, neutral, or unpleasant visual stimuli followed by alcohol or water cues. Psychophysiological cue reactivity measures were obtained during beverage presentation, and subjective reactivity measures were taken directly following beverage presentation. Results Mixed-effect models revealed a significant main effect of beverage and positive (but not negative) affective stimuli on subjective strength of craving, and significant main effects of both positive and negative affective stimuli on ratings of emotionality. Despite the power to detect relatively small interaction effects, no significant interactions were observed between affect and beverage conditions on any reactivity measure. A key finding of this study is that positive affective stimuli commonly associated with drinking situations can induce craving in the absence of alcohol cues. Conclusions Main effects of beverage cue replicated results from previous studies. In addition, positive affective stimuli influenced craving strength. Beverage and affective cues showed no interaction effects. PMID:18604601

  10. Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis.

    PubMed

    Kirste, Imke; Nicola, Zeina; Kronenberg, Golo; Walker, Tara L; Liu, Robert C; Kempermann, Gerd

    2015-03-01

    We have previously hypothesized that the reason why physical activity increases precursor cell proliferation in adult neurogenesis is that movement serves as non-specific signal to evoke the alertness required to meet cognitive demands. Thereby a pool of immature neurons is generated that are potentially recruitable by subsequent cognitive stimuli. Along these lines, we here tested whether auditory stimuli might exert a similar non-specific effect on adult neurogenesis in mice. We used the standard noise level in the animal facility as baseline and compared this condition to white noise, pup calls, and silence. In addition, as patterned auditory stimulus without ethological relevance to mice we used piano music by Mozart (KV 448). All stimuli were transposed to the frequency range of C57BL/6 and hearing was objectified with acoustic evoked potentials. We found that except for white noise all stimuli, including silence, increased precursor cell proliferation (assessed 24 h after labeling with bromodeoxyuridine, BrdU). This could be explained by significant increases in BrdU-labeled Sox2-positive cells (type-1/2a). But after 7 days, only silence remained associated with increased numbers of BrdU-labeled cells. Compared to controls at this stage, exposure to silence had generated significantly increased numbers of BrdU/NeuN-labeled neurons. Our results indicate that the unnatural absence of auditory input as well as spectrotemporally rich albeit ethological irrelevant stimuli activate precursor cells-in the case of silence also leading to greater numbers of newborn immature neurons-whereas ambient and unstructured background auditory stimuli do not. PMID:24292324

  11. Invisible visual stimuli elicit increases in alpha-band power.

    PubMed

    Bareither, Isabelle; Chaumon, Maximilien; Bernasconi, Fosco; Villringer, Arno; Busch, Niko A

    2014-09-01

    The cerebral cortex responds to stimuli of a wide range of intensities. Previous studies have demonstrated that undetectably weak somatosensory stimuli cause a functional deactivation or inhibition in somatosensory cortex. In the present study, we tested whether invisible visual stimuli lead to similar responses, indicated by an increase in EEG alpha-band power-an index of cortical excitability. We presented subliminal and supraliminal visual stimuli after estimating each participant's detection threshold. Stimuli consisted of peripherally presented small circular patches that differed in their contrast to a background consisting of a random white noise pattern. We demonstrate that subliminal and supraliminal stimuli each elicit specific neuronal response patterns. Supraliminal stimuli evoked an early, strongly phase-locked lower-frequency response representing the evoked potential and induced a decrease in alpha-band power from 400 ms on. By contrast, subliminal visual stimuli induced an increase of non-phase-locked power around 300 ms that was maximal within the alpha-band. This response might be due to an inhibitory mechanism, which reduces spurious visual activation that is unlikely to result from external stimuli. PMID:24872526

  12. Multi-Stimuli Responsive Macromolecules and Their Assemblies

    PubMed Central

    Zhuang, Jiaming; Gordon, Mallory; Ventura, Judy; Li, Longyu; Thayumanavan, S.

    2013-01-01

    In this review, we outline examples that illustrate the design criteria for achieving macromolecular assemblies that incorporate a combination of two or more chemical, physical or biological stimuli-responsive components. Progress in both fundamental investigation into the phase transformations of these polymers in response to multiple stimuli and their utilization in a variety of pratical applications have been highlighted. Using these examples, we aim to explain the origin of employed mechanisms of stimuli responsiveness which may serve as a guideline to inspire future design of multi-stimuli responsive materials. PMID:23765263

  13. Individualized and Clinically Derived Stimuli Activate Limbic Structures in Depression: An fMRI Study

    PubMed Central

    Kessler, Henrik; Taubner, Svenja; Buchheim, Anna; Münte, Thomas F.; Stasch, Michael; Kächele, Horst; Roth, Gerhard; Heinecke, Armin; Erhard, Peter; Cierpka, Manfred; Wiswede, Daniel

    2011-01-01

    Objectives In the search for neurobiological correlates of depression, a major finding is hyperactivity in limbic-paralimbic regions. However, results so far have been inconsistent, and the stimuli used are often unspecific to depression. This study explored hemodynamic responses of the brain in patients with depression while processing individualized and clinically derived stimuli. Methods Eighteen unmedicated patients with recurrent major depressive disorder and 17 never-depressed control subjects took part in standardized clinical interviews from which individualized formulations of core interpersonal dysfunction were derived. In the patient group such formulations reflected core themes relating to the onset and maintenance of depression. In controls, formulations reflected a major source of distress. This material was thereafter presented to subjects during functional magnetic resonance imaging (fMRI) assessment. Results Increased hemodynamic responses in the anterior cingulate cortex, medial frontal gyrus, fusiform gyrus and occipital lobe were observed in both patients and controls when viewing individualized stimuli. Relative to control subjects, patients with depression showed increased hemodynamic responses in limbic-paralimbic and subcortical regions (e.g. amygdala and basal ganglia) but no signal decrease in prefrontal regions. Conclusions This study provides the first evidence that individualized stimuli derived from standardized clinical interviewing can lead to hemodynamic responses in regions associated with self-referential and emotional processing in both groups and limbic-paralimbic and subcortical structures in individuals with depression. Although the regions with increased responses in patients have been previously reported, this study enhances the ecological value of fMRI findings by applying stimuli that are of personal relevance to each individual's depression. PMID:21283580

  14. The Search for Optimal Visual Stimuli

    NASA Technical Reports Server (NTRS)

    Watson, Andrew B.; Ellis, Stephen R. (Technical Monitor)

    1997-01-01

    In 1983, Watson, Barlow and Robson published a brief report in which they explored the relative visibility of targets that varied in size, shape, spatial frequency, speed, and duration (referred to subsequently here as WBR). A novel aspect of that paper was that visibility was quantified in terms of threshold contrast energy, rather than contrast. As they noted, this provides a more direct measure of the efficiency with which various patterns are detected, and may be more edifying as to the underlying detection machinery. For example, under certain simple assumptions, the waveform of the most efficiently detected signal is an estimate of the receptive field of the visual system's most efficient detector. Thus one goal of their experiment Basuto search for the stimulus that the 'eye sees best'. Parenthetically, the search for optimal stimuli may be seen as the most general and sophisticated variant of the traditional 'subthreshold summation' experiment, in which one measures the effect upon visibility of small probes combined with a base stimulus.

  15. Anchoring in Numeric Judgments of Visual Stimuli.

    PubMed

    Langeborg, Linda; Eriksson, Mårten

    2016-01-01

    This article investigates effects of anchoring in age estimation and estimation of quantities, two tasks which to different extents are based on visual stimuli. The results are compared to anchoring in answers to classic general knowledge questions that rely on semantic knowledge. Cognitive load was manipulated to explore possible differences between domains. Effects of source credibility, manipulated by differing instructions regarding the selection of anchor values (no information regarding anchor selection, information that the anchors are randomly generated or information that the anchors are answers from an expert) on anchoring were also investigated. Effects of anchoring were large for all types of judgments but were not affected by cognitive load or by source credibility in either one of the researched domains. A main effect of cognitive load on quantity estimations and main effects of source credibility in the two visually based domains indicate that the manipulations were efficient. Implications for theoretical explanations of anchoring are discussed. In particular, because anchoring did not interact with cognitive load, the results imply that the process behind anchoring in visual tasks is predominantly automatic and unconscious. PMID:26941684

  16. Stimuli-responsive cement-reinforced rubber.

    PubMed

    Musso, Simone; Robisson, Agathe; Maheshwar, Sudeep; Ulm, Franz-Josef

    2014-05-14

    In this work, we report the successful development of a cement-rubber reactive composite with reversible mechanical properties. Initially, the composite behaves like rubber containing inert filler, but when exposed to water, it increases in volume and reaches a stiffness that is intermediate between that of hydrogenated nitrile butadiene rubber (HNBR) and hydrated cement, while maintaining a relatively large ductility characteristic of rubber. After drying, the modulus increases even further up to 400 MPa. Wet/drying cycles prove that the elastic modulus can reversibly change between 150 and 400 MPa. Utilizing attenuated total reflection Fourier transform infrared spectroscopy), we demonstrate that the high pH produced by the hydration of cement triggers the hydrolysis of the rubber nitrile groups into carboxylate anions. Thus, the salt bridges, generated between the carboxylate anions of the elastomer and the cations of the filler, are responsible for the reversible variations in volume and elastic modulus of the composite as a consequence of environmental moisture exposure. These results reveal that cement nanoparticles can successfully be used to accomplish a twofold task: (a) achieve an original postpolymerization modification that allows one to work with carboxylate HNBR (HXNBR) not obtained by direct copolymerization of carboxylate monomers with butadiene, and (b) synthesize a stimuli-responsive polymeric composite. This new type of material, having an ideal behavior for sealing application, could be used as an alternative to cement for oil field zonal isolation applications. PMID:24734968

  17. Anchoring in Numeric Judgments of Visual Stimuli

    PubMed Central

    Langeborg, Linda; Eriksson, Mårten

    2016-01-01

    This article investigates effects of anchoring in age estimation and estimation of quantities, two tasks which to different extents are based on visual stimuli. The results are compared to anchoring in answers to classic general knowledge questions that rely on semantic knowledge. Cognitive load was manipulated to explore possible differences between domains. Effects of source credibility, manipulated by differing instructions regarding the selection of anchor values (no information regarding anchor selection, information that the anchors are randomly generated or information that the anchors are answers from an expert) on anchoring were also investigated. Effects of anchoring were large for all types of judgments but were not affected by cognitive load or by source credibility in either one of the researched domains. A main effect of cognitive load on quantity estimations and main effects of source credibility in the two visually based domains indicate that the manipulations were efficient. Implications for theoretical explanations of anchoring are discussed. In particular, because anchoring did not interact with cognitive load, the results imply that the process behind anchoring in visual tasks is predominantly automatic and unconscious. PMID:26941684

  18. Stereotypic vision: how stereotypes disambiguate visual stimuli.

    PubMed

    Correll, Joshua; Wittenbrink, Bernd; Crawford, Matthew T; Sadler, Melody S

    2015-02-01

    Three studies examined how participants use race to disambiguate visual stimuli. Participants performed a first-person-shooter task in which Black and White targets appeared holding either a gun or an innocuous object (e.g., a wallet). In Study 1, diffusion analysis (Ratcliff, 1978) showed that participants rapidly acquired information about a gun when it appeared in the hands of a Black target, and about an innocuous object in the hands of a White target. For counterstereotypic pairings (armed Whites, unarmed Blacks), participants acquired information more slowly. In Study 2, eye tracking showed that participants relied on more ambiguous information (measured by visual angle from fovea) when responding to stereotypic targets; for counterstereotypic targets, they achieved greater clarity before responding. In Study 3, participants were briefly exposed to targets (limiting access to visual information) but had unlimited time to respond. In spite of their slow, deliberative responses, they showed racial bias. This pattern is inconsistent with control failure and suggests that stereotypes influenced identification of the object. All 3 studies show that race affects visual processing by supplementing objective information. PMID:25603373

  19. Relating tribological stimuli to somatosensory electroencephalographic responses.

    PubMed

    Oezguen, Novaf; Schubert, Kristof J; Bergmann, Ronny; Bennewitz, Roland; Strauss, Daniel J

    2015-08-01

    The present study deals with the extraction of neural correlates evoked by tactile stimulation of the human fingertip. A reciprocal sliding procedure was performed using a home-built tribometer while simultaneously electroencephalographic (EEG) data from the somatosensory cortex was recorded. The tactile stimuli were delivered by a sliding block with equidistant, perpendicular ridges. The experiments were designed and performed in a fully passive way to prevent attentional locked influences from the subjects. In order to improve the signal-to-noise ratio (SNR) of event related single-trials (ERPs), nonlocal means in addition to 2D-anisotropic denoising schemes based on tight Gabor frames were applied. This novel approach allowed for an easier extraction of ERP alternations. A negative correlation between the latency of the P100 component of the resulting brain responses and the intensity of the underlying lateral forces was found. These findings lead to the conclusion that an increasing stimulus intensity results in a decreasing latency of the brain responses. PMID:26738177

  20. Psychophysiological Response Patterns to Affective Film Stimuli

    PubMed Central

    Bos, Marieke G. N.; Jentgens, Pia; Beckers, Tom; Kindt, Merel

    2013-01-01

    Psychophysiological research on emotion utilizes various physiological response measures to index activation of the defense system. Here we tested 1) whether acoustic startle reflex (ASR), skin conductance response (SCR) and heart rate (HR) elicited by highly arousing stimuli specifically reflect a defensive state and 2) the relation between resting heart rate variability (HRV) and affective responding. In a within-subject design, participants viewed film clips with a positive, negative and neutral content. In contrast to SCR and HR, we show that ASR differentiated between negative, neutral and positive states and can therefore be considered as a reliable index of activation of the defense system. Furthermore, resting HRV was associated with affect-modulated characteristics of ASR, but not with SCR or HR. Interestingly, individuals with low-HRV showed less differentiation in ASR between affective states. We discuss the important value of ASR in psychophysiological research on emotion and speculate on HRV as a potential biological marker for demarcating adaptive from maladaptive responding. PMID:23646134

  1. 'Ecstasy' as a social drug: MDMA preferentially affects responses to emotional stimuli with social content.

    PubMed

    Wardle, Margaret C; Kirkpatrick, Matthew G; de Wit, Harriet

    2014-08-01

    3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is used recreationally to improve mood and sociability, and has generated clinical interest as a possible adjunct to psychotherapy. One way that MDMA may produce positive 'prosocial' effects is by changing responses to emotional stimuli, especially stimuli with social content. Here, we examined for the first time how MDMA affects subjective responses to positive, negative and neutral emotional pictures with and without social content. We hypothesized that MDMA would dose-dependently increase reactivity to positive emotional stimuli and dampen reactivity to negative stimuli, and that these effects would be most pronounced for pictures with people in them. The data were obtained from two studies using similar designs with healthy occasional MDMA users (total N = 101). During each session, participants received MDMA (0, 0.75 and 1.5 mg/kg oral), and then rated their positive and negative responses to standardized positive, negative and neutral pictures with and without social content. MDMA increased positive ratings of positive social pictures, but reduced positive ratings of non-social positive pictures. We speculate this 'socially selective' effect contributes to the prosocial effects of MDMA by increasing the comparative value of social contact and closeness with others. This effect may also contribute to its attractiveness to recreational users. PMID:24682132

  2. Conditional Reinforcers and Informative Stimuli in a Constant Environment

    ERIC Educational Resources Information Center

    Boutros, Nathalie; Davison, Michael; Elliffe, Douglas

    2009-01-01

    Five pigeons responded on steady-state concurrent variable-interval variable-interval schedules of food presentation in which half of the foods were removed and replaced with nonfood stimuli. Across conditions, the stimuli were either paired or unpaired with food, and the correlation between the ratio of food deliveries on the two alternatives and…

  3. Logical Rules and the Classification of Integral-Dimension Stimuli

    ERIC Educational Resources Information Center

    Little, Daniel R.; Nosofsky, Robert M.; Donkin, Christopher; Denton, Stephen E.

    2013-01-01

    A classic distinction in perceptual information processing is whether stimuli are composed of separable dimensions, which are highly analyzable, or integral dimensions, which are processed holistically. Previous tests of a set of logical-rule models of classification have shown that separable-dimension stimuli are processed serially if the…

  4. Identity Matching-to-Sample with Olfactory Stimuli in Rats

    ERIC Educational Resources Information Center

    Pena, Tracy; Pitts, Raymond C.; Galizio, Mark

    2006-01-01

    Identity matching-to-sample has been difficult to demonstrate in rats, but most studies have used visual stimuli. There is evidence that rats can acquire complex forms of olfactory stimulus control, and the present study explored the possibility that identity matching might be facilitated in rats if olfactory stimuli were used. Four rats were…

  5. Transitive Responding in Hooded Crows Requires Linearly Ordered Stimuli

    ERIC Educational Resources Information Center

    Lazareva, Olga F.; Smirnova, Anna A.; Bagozkaja, Maria S.; Zorina, Zoya A.; Rayevsky, Vladimir V.; Wasserman, Edward A.

    2004-01-01

    Eight crows were taught to discriminate overlapping pairs of visual stimuli (A+ B-, B+ C-, C+ D-, and D+ E-). For 4 birds, the stimuli were colored cards with a circle of the same color on the reverse side whose diameter decreased from A to E (ordered feedback group). These circles were made available for comparison to potentially help the crows…

  6. Imagery Arousal as a Function of Exposure to Artistic Stimuli.

    ERIC Educational Resources Information Center

    Bilotta, Joseph

    The purpose of this study was to determine to what extent music and art can arouse imagery experiences in an audience. Because of the relationship found between imagery and the arts in past research, it was hypothesized that artistic stimuli would have a greater influence on imagery than other kinds of stimuli (art-information or non-artistic).…

  7. Exploring Visuomotor Priming Following Biological and Non-Biological Stimuli

    ERIC Educational Resources Information Center

    Gowen, E.; Bradshaw, C.; Galpin, A.; Lawrence, A.; Poliakoff, E.

    2010-01-01

    Observation of human actions influences the observer's own motor system, termed visuomotor priming, and is believed to be caused by automatic activation of mirror neurons. Evidence suggests that priming effects are larger for biological (human) as opposed to non-biological (object) stimuli and enhanced when viewing stimuli in mirror compared to…

  8. Comparing Methods of Identifying Reinforcing Stimuli in School Consultation

    ERIC Educational Resources Information Center

    Damon, Sharon; Riley-Tillman, T. Chris; Fiorello, Catherine

    2008-01-01

    Reinforcement-based interventions, the most frequently used treatments for school-age children, rely on accurately identifying stimuli that will serve to reinforce appropriate classroom behavior. Research has consistently demonstrated that the results from a forced-choice pairing procedure are the best predictors of reinforcing stimuli.…

  9. Subliminal sexual stimuli facilitate genital response in women.

    PubMed

    Ponseti, Jorge; Bosinski, Hartmut A G

    2010-10-01

    Visual sexual stimuli (VSS) are believed to undergo an automatic process of stimulus appraisal and (genital or subjective) response generation. Consistent with this belief, studies have found that subliminal VSS can facilitate responses to subsequent sexual stimulus presentations. We tested whether subliminal sexual stimuli facilitated a genital response in women and, furthermore, whether this genital response could be modulated by both opposite-sex stimuli and same-sex stimuli (i.e., whether the genital response to subliminal stimuli is category-specific or nonspecific). Twenty heterosexual women underwent vaginal photoplethysmography while being subliminally (20 ms) exposed to same-sex, opposite-sex, and nonsexual slides in a priming experiment. Vaginal pulse amplitude was increased when target stimuli were preceded by both opposite-sex and same-sex priming stimuli relative to nonsexual priming stimuli. This finding suggests that subliminal VSS were subjected to automatic stimulus processing, thereby facilitating nonspecific genital response preparation. Results are discussed in terms of implicit and explicit memory access and the evolutionary benefit of female nonspecific genital response. PMID:20041283

  10. Inverse Target- and Cue-Priming Effects of Masked Stimuli

    ERIC Educational Resources Information Center

    Mattler, Uwe

    2007-01-01

    The processing of a visual target that follows a briefly presented prime stimulus can be facilitated if prime and target stimuli are similar. In contrast to these positive priming effects, inverse priming effects (or negative compatibility effects) have been found when a mask follows prime stimuli before the target stimulus is presented: Responses…

  11. Freeze or Flee? Negative Stimuli Elicit Selective Responding

    ERIC Educational Resources Information Center

    Estes, Zachary; Verges, Michelle

    2008-01-01

    Humans preferentially attend to negative stimuli. A consequence of this automatic vigilance for negative valence is that negative words elicit slower responses than neutral or positive words on a host of cognitive tasks. Some researchers have speculated that negative stimuli elicit a general suppression of motor activity, akin to the freezing…

  12. Sex Differences in Response to Visual Sexual Stimuli: A Review

    PubMed Central

    Rupp, Heather A.; Wallen, Kim

    2009-01-01

    This article reviews what is currently known about how men and women respond to the presentation of visual sexual stimuli. While the assumption that men respond more to visual sexual stimuli is generally empirically supported, previous reports of sex differences are confounded by the variable content of the stimuli presented and measurement techniques. We propose that the cognitive processing stage of responding to sexual stimuli is the first stage in which sex differences occur. The divergence between men and women is proposed to occur at this time, reflected in differences in neural activation, and contribute to previously reported sex differences in downstream peripheral physiological responses and subjective reports of sexual arousal. Additionally, this review discusses factors that may contribute to the variability in sex differences observed in response to visual sexual stimuli. Factors include participant variables, such as hormonal state and socialized sexual attitudes, as well as variables specific to the content presented in the stimuli. Based on the literature reviewed, we conclude that content characteristics may differentially produce higher levels of sexual arousal in men and women. Specifically, men appear more influenced by the sex of the actors depicted in the stimuli while women’s response may differ with the context presented. Sexual motivation, perceived gender role expectations, and sexual attitudes are possible influences. These differences are of practical importance to future research on sexual arousal that aims to use experimental stimuli comparably appealing to men and women and also for general understanding of cognitive sex differences. PMID:17668311

  13. New candidates for extremely metal-poor emission-line galaxies in the SDSS/BOSS DR10

    NASA Astrophysics Data System (ADS)

    Guseva, N. G.; Izotov, Y. I.; Fricke, K. J.; Henkel, C.

    2015-07-01

    We present a spectroscopic study of eight extremely low-metallicity candidate emission-line galaxies with oxygen abundances possibly below 12 + log O/H = 7.35. These galaxies were selected from data release 10 of the Sloan Digital Sky Survey/Baryon Oscillation Spectroscopic Survey (SDSS/BOSS DR10). We will call these extremely metal-deficient (XMD) galaxies. The electron temperature-sensitive emission line [O iii] λ4363 is detected in three galaxies and marginally detected in two galaxies, allowing for abundance determination by a "direct" method. Because of large uncertainties in the [O iii]λ4363 Å line fluxes, we also calculated oxygen abundance in these galaxies together with the remaining three galaxies using a strong-line semi-empirical method. This method gives oxygen abundances higher than 7.35 for three galaxies with detected [O iii]λ4363 Å line and lower than 7.35 for the remaining five objects of the sample. The newly-discovered galaxies represent excellent targets for follow-up spectroscopic observations with the largest telescopes to improve the oxygen abundance determination and to increase the number of these very rare low-metallicity objects. The extreme location of the most massive and luminous XMD galaxies and XMD candidates in the stellar mass-metallicity diagram implies that these galaxies may be genuine young objects. With stellar masses of up to ~107-108M⊙, the galaxies are not chemically enriched and strongly deviate to lower metallicity as compared to the relation obtained for a large sample of low-redshift, star-forming galaxies. Tables 2-4 are available in electronic form at http://www.aanda.org

  14. Optimal Decision Stimuli for Risky Choice Experiments: An Adaptive Approach

    PubMed Central

    Cavagnaro, Daniel R.; Gonzalez, Richard; Myung, Jay I.; Pitt, Mark A.

    2014-01-01

    Collecting data to discriminate between models of risky choice requires careful selection of decision stimuli. Models of decision making aim to predict decisions across a wide range of possible stimuli, but practical limitations force experimenters to select only a handful of them for actual testing. Some stimuli are more diagnostic between models than others, so the choice of stimuli is critical. This paper provides the theoretical background and a methodological framework for adaptive selection of optimal stimuli for discriminating among models of risky choice. The approach, called Adaptive Design Optimization (ADO), adapts the stimulus in each experimental trial based on the results of the preceding trials. We demonstrate the validity of the approach with simulation studies aiming to discriminate Expected Utility, Weighted Expected Utility, Original Prospect Theory, and Cumulative Prospect Theory models. PMID:24532856

  15. Rapid temporal recalibration is unique to audiovisual stimuli.

    PubMed

    Van der Burg, Erik; Orchard-Mills, Emily; Alais, David

    2015-01-01

    Following prolonged exposure to asynchronous multisensory signals, the brain adapts to reduce the perceived asynchrony. Here, in three separate experiments, participants performed a synchrony judgment task on audiovisual, audiotactile or visuotactile stimuli and we used inter-trial analyses to examine whether temporal recalibration occurs rapidly on the basis of a single asynchronous trial. Even though all combinations used the same subjects, task and design, temporal recalibration occurred for audiovisual stimuli (i.e., the point of subjective simultaneity depended on the preceding trial's modality order), but none occurred when the same auditory or visual event was combined with a tactile event. Contrary to findings from prolonged adaptation studies showing recalibration for all three combinations, we show that rapid, inter-trial recalibration is unique to audiovisual stimuli. We conclude that recalibration occurs at two different timescales for audiovisual stimuli (fast and slow), but only on a slow timescale for audiotactile and visuotactile stimuli. PMID:25200176

  16. Emotional attention for erotic stimuli: Cognitive and brain mechanisms.

    PubMed

    Sennwald, Vanessa; Pool, Eva; Brosch, Tobias; Delplanque, Sylvain; Bianchi-Demicheli, Francesco; Sander, David

    2016-06-01

    It has long been posited that among emotional stimuli, only negative threatening information modulates early shifts of attention. However, in the last few decades there has been an increase in research showing that attention is also involuntarily oriented toward positive rewarding stimuli such as babies, food, and erotic information. Because reproduction-related stimuli have some of the largest effects among positive stimuli on emotional attention, the present work reviews recent literature and proposes that the cognitive and cerebral mechanisms underlying the involuntarily attentional orientation toward threat-related information are also sensitive to erotic information. More specifically, the recent research suggests that both types of information involuntarily orient attention due to their concern relevance and that the amygdala plays an important role in detecting concern-relevant stimuli, thereby enhancing perceptual processing and influencing emotional attentional processes. PMID:26179894

  17. Optimal Decision Stimuli for Risky Choice Experiments: An Adaptive Approach.

    PubMed

    Cavagnaro, Daniel R; Gonzalez, Richard; Myung, Jay I; Pitt, Mark A

    2013-02-01

    Collecting data to discriminate between models of risky choice requires careful selection of decision stimuli. Models of decision making aim to predict decisions across a wide range of possible stimuli, but practical limitations force experimenters to select only a handful of them for actual testing. Some stimuli are more diagnostic between models than others, so the choice of stimuli is critical. This paper provides the theoretical background and a methodological framework for adaptive selection of optimal stimuli for discriminating among models of risky choice. The approach, called Adaptive Design Optimization (ADO), adapts the stimulus in each experimental trial based on the results of the preceding trials. We demonstrate the validity of the approach with simulation studies aiming to discriminate Expected Utility, Weighted Expected Utility, Original Prospect Theory, and Cumulative Prospect Theory models. PMID:24532856

  18. Emotional content of stimuli improves visuospatial working memory.

    PubMed

    González-Garrido, Andrés Antonio; López-Franco, Adriana Liset; Gómez-Velázquez, Fabiola Reveca; Ramos-Loyo, Julieta; Sequeira, Henrique

    2015-01-12

    Processing and storage in visuospatial working memory (VSWM) seem to depend on attention-based mechanisms. In order to explore the effect of attention-attractive stimuli, such as emotional faces on VSWM performance, ERPs were obtained from 20 young adults while reproducing spatial sequences of six facial (happy and neutral) and non-facial control stimuli in inverse order. Behavioral performances revealed that trials with happy facial expressions resulted in a significantly higher amount of correct responses. For positive emotional facial stimuli, N170 amplitude was higher over right temporo-parietal regions, while P2 amplitude was higher over frontal and lower over parietal regions. In addition, LPP amplitude was also significantly higher for this type of stimuli. Both behavioral and electrophysiological results support the notion of the domain-general attention-based mechanism of VSWM maintenance, in which spatial to-be-remembered locations might be influenced by the emotional content of the stimuli. PMID:25445376

  19. Violent Reactions from Non-Shock Stimuli

    NASA Astrophysics Data System (ADS)

    Sandusky, Harold

    2007-06-01

    Most reactions are thermally initiated, whether from direct heating or dissipation of energy from mechanical, shock, or electrical stimuli. For other than prompt shock initiation, the reaction must be able to spread through porosity or over large surface area to become more violent than just rupturing any confinement. While burning rates are important, high-strain mechanical properties are nearly so, either by reducing existing porosity or generating additional surface area through fracture. The first example is deflagration-to-detonation transition (DDT) in porous beds. During the early stages, weak compressive waves ahead of the convective ignition front will reduce porosity, thereby restricting the spread of combustion and the pressure buildup. If, however, pressure increases faster than can be relieved by loss of confinement, coalescing compressive waves can initiate reaction at hot spots from rapid pore collapse. This compressive reaction can drive a shockwave that transits to detonation, the most violent reaction in any scenario. It has been shown that reaction violence is reduced in DDT experiments if the binder is softened, either by raising the initial temperature or adding a solvent. An example of the role of mechanical properties in enhancing reaction violence through fracturing occurs when cavities in projectile fills collapse during acceleration in the gun barrel, which is referred to as setback. Explosives with soft rubber binders will deform and undergo mild reaction from shear heating within the explosive and adiabatic compression of any gas in the cavity. Stiff explosives are similarly ignited, but also fracture and generate additional surface area for a violent event. The last example to be considered is slow cook-off, where thermal damage can increase burning rate as well as provide porosity to enhance the pressure buildup. As reaction spreads from the zone of thermal run-away, an explosive binder that resists breakup will limit the violence.

  20. Polyamines as olfactory stimuli in the goldfish Carassius auratus.

    PubMed

    Rolen, S H; Sorensen, P W; Mattson, D; Caprio, J

    2003-05-01

    Electrophysiological responses of goldfish olfactory receptor neurons (ORNs) and goldfish behavioral responses to polyamines were investigated in vivo. Electro-olfactogram (EOG) recordings indicated that polyamines (putrescine, cadaverine and spermine) are potent olfactory stimuli for goldfish with estimated electrophysiological thresholds of 10(-8)-10(-7) mol l(-1), similar to that for L-arginine, the most stimulatory amino acid. Although thresholds were similar, the magnitude of the EOG responses to intermediate (10(-5)-10(-4) mol l(-1)) and high (10(-3) mol l(-1)) concentrations of polyamines dwarfed the responses to amino acids and related single amine containing compounds (amylamine and butylamine). The EOG responses to 0.1 mmol l(-1) putrescine, cadaverine and spermine were, respectively, 4.2x, 4.3x and 10.3x the response of the standard, 0.1 mmol l(-1) L-arginine. Electrophysiological cross-adaptation experiments indicated that polyamine receptor sites are independent from those to L-amino acids (alanine, arginine, glutamate, lysine, methionine and ornithine), bile salts (sodium taurocholate and taurolithocholate), the single amine containing compounds (amylamine and butylamine) and ATP. Further, the cross-adaptation experiments revealed the existence of independent receptor sites for the different polyamines tested. Pharmacological experiments suggested that polyamine odorant transduction does not primarily involve the cyclic AMP and IP(3) second messenger pathways. Behavioral assays indicated that polyamines are attractants that elicit feeding behavior similar to that elicited by L-amino acids. PMID:12682100

  1. Emotional enhancement of immediate memory: Positive pictorial stimuli are better recognized than neutral or negative pictorial stimuli

    PubMed Central

    Chainay, Hanna; Michael, George A.; Vert-pré, Mélissa; Landré, Lionel; Plasson, Amandine

    2012-01-01

    We examined emotional memory enhancement (EEM) for negative and positive pictures while manipulating encoding and retrieval conditions. Two groups of 40 participants took part in this study. Both groups performed immediate implicit (categorization task) and explicit (recognition task) retrieval, but for one group the tasks were preceded by incidental encoding and for the other group by intentional encoding. As indicated by the sensitivity index (dʹ), after incidental encoding positive stimuli were easier to recognize than negative and neutral stimuli. Participants’ response criterion was more liberal for negative stimuli than for both positive and neutral ones, independent of encoding condition. In the implicit retrieval task, participants were slower in categorizing positive than negative and neutral stimuli. However, the priming effect was larger for emotional than for neutral stimuli. These results are discussed in the context of the idea that the effect of emotion on immediate memory enhancement may depend on the intentionality to encode and retrieve information. PMID:22956991

  2. Implicit Training of Nonnative Speech Stimuli

    ERIC Educational Resources Information Center

    Vlahou, Eleni L.; Protopapas, Athanassios; Seitz, Aaron R.

    2012-01-01

    Learning nonnative speech contrasts in adulthood has proven difficult. Standard training methods have achieved moderate effects using explicit instructions and performance feedback. In this study, the authors question preexisting assumptions by demonstrating a superiority of implicit training procedures. They trained 3 groups of Greek adults on a…

  3. Affective Priming with Auditory Speech Stimuli

    ERIC Educational Resources Information Center

    Degner, Juliane

    2011-01-01

    Four experiments explored the applicability of auditory stimulus presentation in affective priming tasks. In Experiment 1, it was found that standard affective priming effects occur when prime and target words are presented simultaneously via headphones similar to a dichotic listening procedure. In Experiment 2, stimulus onset asynchrony (SOA) was…

  4. Dynamic bioactive stimuli-responsive polymeric surfaces

    NASA Astrophysics Data System (ADS)

    Pearson, Heather Marie

    This dissertation focuses on the design, synthesis, and development of antimicrobial and anticoagulant surfaces of polyethylene (PE), polypropylene (PP), and poly(tetrafluoroethylene) (PTFE) polymers. Aliphatic polymeric surfaces of PE and PP polymers functionalized using click chemistry reactions by the attachment of --COOH groups via microwave plasma reactions followed by functionalization with alkyne moieties. Azide containing ampicillin (AMP) was synthesized and subsequently clicked into the alkyne prepared PE and PP surfaces. Compared to non-functionalized PP and PE surfaces, the AMP clicked surfaces exhibited substantially enhanced antimicrobial activity against Staphylococcus aureus bacteria. To expand the biocompatibility of polymeric surface anticoagulant attributes, PE and PTFE surfaces were functionalized with pH-responsive poly(2-vinyl pyridine) (P2VP) and poly(acrylic acid) (PAA) polyelectrolyte tethers terminated with NH2 and COOH groups. The goal of these studies was to develop switchable stimuli-responsive polymeric surfaces that interact with biological environments and display simultaneous antimicrobial and anticoagulant properties. Antimicrobial AMP was covalently attached to --COOH terminal ends of protected PAA, while anticoagulant heparin (HEP) was attached to terminal --NH2 groups of P2VP. When pH < 2.3, the P2VP segments are protonated and extend, but for pH > 5.5, they collapse while the PAA segments extend. Such surfaces, when exposed to Staphylococcus aureus, inhibit bacterial growth due to the presence of AMP, as well as are effective anticoagulants due to the presence of covalently attached HEP. Comparison of these "dynamic" pH responsive surfaces with "static" surfaces terminated with AMP entities show significant enhancement of longevity and surface activity against microbial film formation. The last portion of this dissertation focuses on the covalent attachment of living T1 and Φ11 bacteriophages (phages) on PE and PTFE surface

  5. Numerosity judgments for tactile stimuli distributed over the body surface.

    PubMed

    Gallace, Alberto; Tan, Hong Z; Spence, Charles

    2006-01-01

    A large body of research now supports the claim that two different and dissociable processes are involved in making numerosity judgments regarding visual stimuli: subitising (fast and nearly errorless) for up to 4 stimuli, and counting (slow and error-prone) when more than 4 stimuli are presented. We studied tactile numerosity judgments for combinations of 1-7 vibrotactile stimuli presented simultaneously over the body surface. In experiment 1, the stimuli were presented once, while in experiment 2 conditions of single presentation and repeated presentation of the stimulus were compared. Neither experiment provided any evidence for a discontinuity in the slope of either the RT or error data suggesting that subitisation does not occur for tactile stimuli. By systematically varying the intensity of the vibrotactile stimuli in experiment 3, we were able to demonstrate that participants were not simply using the 'global intensity' of the whole tactile display to make their tactile numerosity judgments, but were, instead, using information concerning the number of tactors activated. The results of the three experiments reported here are discussed in relation to current theories of counting and subitising, and potential implications for the design of tactile user interfaces are highlighted. PMID:16583769

  6. Meet the Fribbles: novel stimuli for use within behavioural research

    PubMed Central

    Barry, Tom J.; Griffith, James W.; De Rossi, Stephanie; Hermans, Dirk

    2014-01-01

    Clinical researchers make use of experimental models for mental disorders. In many cases, these models use stimuli that are relevant to the disorder under scrutiny, which allows one to experimentally investigate the factors that contribute to the development of the disorder. For example, one might use spiders or spider-like stimuli in the study of specific phobia. More broadly, researchers often make use of real-world stimuli such as images of animals, geometrical shapes or emotional words. However, these stimuli are often limited in their experimental controllability and their applicability to the disorder in question. We present a novel set of animal-like stimuli, called Fribbles, for use within behavioural research. Fribbles have desirable properties for use in research because they are similar to real-world stimuli, but due to their novelty, participants will not have had previous experience with them. They also have known properties that can be experimentally manipulated. We present an investigation into similarity between Fribbles in order to illustrate their utility in research that relies on comparisons between similar stimuli. Fribbles offer both experimental control and generalisability to the real world, although some consideration must be made concerning the properties that influence similarity between Fribbles when selecting them along a dimension of similarity. PMID:24575075

  7. The power spectrum and bispectrum of SDSS DR11 BOSS galaxies - II. Cosmological interpretation

    NASA Astrophysics Data System (ADS)

    Gil-Marín, Héctor; Verde, Licia; Noreña, Jorge; Cuesta, Antonio J.; Samushia, Lado; Percival, Will J.; Wagner, Christian; Manera, Marc; Schneider, Donald P.

    2015-09-01

    We examine the cosmological implications of the measurements of the linear growth rate of cosmological structure obtained in a companion paper from the power spectrum and bispectrum monopoles of the Sloan Digital Sky Survey III Baryon Oscillation Spectroscopic Survey Data Release 11, CMASS galaxies. This measurement was of f 0.43σ8, where σ8 is the amplitude of dark matter density fluctuations, and f is the linear growth rate, at the effective redshift of the survey, zeff = 0.57. In conjunction with cosmic microwave background (CMB) data, interesting constraints can be placed on models with non-standard neutrino properties and models where gravity deviates from General Relativity on cosmological scales. In particular, the sum of the masses of the three species of the neutrinos is constrained to mν < 0.49 eV (at 95 per cent confidence level) when the f 0.43σ8 measurement is combined with state-of-the-art CMB measurements. Allowing the effective number of neutrinos to vary as a free parameter does not significantly change these results. When we combine the measurement of f 0.43σ8 with the complementary measurement of fσ8 from the monopole and quadrupole of the two-point correlation function, we are able to obtain an independent measurements of f and σ8. We obtain f = 0.63 ± 0.16 and σ8 = 0.710 ± 0.086 (68 per cent confidence level). This is the first time when these parameters have been able to be measured independently using the redshift-space power spectrum and bispectrum measurements from galaxy clustering data only.

  8. Exploring strategies for classification of external stimuli using statistical features of the plant electrical response

    PubMed Central

    Chatterjee, Shre Kumar; Das, Saptarshi; Maharatna, Koushik; Masi, Elisa; Santopolo, Luisa; Mancuso, Stefano; Vitaletti, Andrea

    2015-01-01

    Plants sense their environment by producing electrical signals which in essence represent changes in underlying physiological processes. These electrical signals, when monitored, show both stochastic and deterministic dynamics. In this paper, we compute 11 statistical features from the raw non-stationary plant electrical signal time series to classify the stimulus applied (causing the electrical signal). By using different discriminant analysis-based classification techniques, we successfully establish that there is enough information in the raw electrical signal to classify the stimuli. In the process, we also propose two standard features which consistently give good classification results for three types of stimuli—sodium chloride (NaCl), sulfuric acid (H2SO4) and ozone (O3). This may facilitate reduction in the complexity involved in computing all the features for online classification of similar external stimuli in future. PMID:25631569

  9. Dense Sampling and Large Volume: The Structure of the Intergalactic Medium from 50,000 SDSS3 BOSS Quasar Absorption Spectra

    NASA Astrophysics Data System (ADS)

    Croft, Rupert A.; Arnau, E.; Aubourg, E.; Bailey, S.; Bechtold, J.; Bhardwaj, V.; Bolton, A.; Borde, A.; Brinkmann, J.; Busca, N.; Carithers, W.; Cen, R.; Charlassier, R.; Cortes, M.; Dall'Aglio, A.; Cristiani, S.; Dawson, K.; Delubac, T.; Font-Ribera, A.; Hamilton, J.; Ho, S.; Lee, K.; LeGoff, J.; Kirkby, D.; Lundgren, B.; Menard, B.; Miralda-Escude, J.; Palanque-Delabrouille, N.; Myers, A.; Paris, I.; Peirani, S.; Petitjean, P.; Pieri, M.; Rich, J.; Rollinde, E.; Ross, N.; Schlegel, D.; Skibba, R.; Slosar, A.; Suzuki, N.; Trac, H.; Vikas, S.; Viel, M.; Wake, D.; Weinberg, D.; White, M.; Yeche, C.

    2012-01-01

    The BOSS quasar spectra analyzed so far contain over a quarter billion pixels of information on the intervening intergalactic medium. The statistical power of BOSS has previously enabled 10% of the eventual full dataset to yield the first measurements of three dimensional large-scale structure in the Lya forest (Slosar et al 2011). Here we present results from a sample several times larger, covering several topics in cosmology and intergalactic medium science which are qualitatively transformed by the dense sampling (20 quasars per square degree) and enormous sky area. These include new constraints on cosmology and the neutrino mass from a Lya forest power spectrum measurement using 20 times more spectra than the largest previously published analysis (from SDSS), a new catalog of metal absorbers and a stacking analysis which has uncovered many metal species never before seen in the intergalactic medium. Cross-correlations of quasars, galaxies, metal lines and Lyman series absorption provide us with a wide variety of probes, including of cosmology, quasar host masses, lifetimes, and absorber galaxy masses. We show several of these results. We also show through correlation function analysis that the prime task, of making a BAO detection from Lya forest clustering, (the first BAO constraint between z=1 and the CMB) is well on the way to completion.

  10. Rod Electroretinograms Elicited by Silent Substitution Stimuli from the Light-Adapted Human Eye

    PubMed Central

    Maguire, John; Parry, Neil R. A.; Kremers, Jan; Kommanapalli, Deepika; Murray, Ian J.; McKeefry, Declan J.

    2016-01-01

    Purpose To demonstrate that silent substitution stimuli can be used to generate electroretinograms (ERGs) that effectively isolate rod photoreceptor function in humans without the need for dark adaptation, and that this approach constitutes a viable alternative to current clinical standard testing protocols. Methods Rod-isolating and non-isolating sinusoidal flicker stimuli were generated on a 4 primary light-emitting diode (LED) Ganzfeld stimulator to elicit ERGs from participants with normal and compromised rod function who had not undergone dark-adaptation. Responses were subjected to Fourier analysis, and the amplitude and phase of the fundamental were used to examine temporal frequency and retinal illuminance response characteristics. Results Electroretinograms elicited by rod-isolating silent substitution stimuli exhibit low-pass temporal frequency response characteristics with an upper response limit of 30 Hz. Responses are optimal between 5 and 8 Hz and between 10 and 100 photopic trolands (Td). There is a significant correlation between the response amplitudes obtained with the silent substitution method and current standard clinical protocols. Analysis of signal-to-noise ratios reveals significant differences between subjects with normal and compromised rod function. Conclusions Silent substitution provides an effective method for the isolation of human rod photoreceptor function in subjects with normal as well as compromised rod function when stimuli are used within appropriate parameter ranges. Translational Relevance This method of generating rod-mediated ERGs can be achieved without time-consuming periods of dark adaptation, provides improved isolation of rod- from cone-based activity, and will lead to the development of faster clinical electrophysiologic testing protocols with improved selectivity. PMID:27617180

  11. Humans can discriminate more than 1 trillion olfactory stimuli.

    PubMed

    Bushdid, C; Magnasco, M O; Vosshall, L B; Keller, A

    2014-03-21

    Humans can discriminate several million different colors and almost half a million different tones, but the number of discriminable olfactory stimuli remains unknown. The lay and scientific literature typically claims that humans can discriminate 10,000 odors, but this number has never been empirically validated. We determined the resolution of the human sense of smell by testing the capacity of humans to discriminate odor mixtures with varying numbers of shared components. On the basis of the results of psychophysical testing, we calculated that humans can discriminate at least 1 trillion olfactory stimuli. This is far more than previous estimates of distinguishable olfactory stimuli. It demonstrates that the human olfactory system, with its hundreds of different olfactory receptors, far outperforms the other senses in the number of physically different stimuli it can discriminate. PMID:24653035

  12. Do extraverts process social stimuli differently from introverts?

    PubMed Central

    Fishman, Inna; Ng, Rowena; Bellugi, Ursula

    2011-01-01

    The personality trait of extraversion has been linked to the network of brain systems controlling sensitivity to cues of reward and generating approach behavior in response, but little is known about whether extraverts’ neural circuits are especially sensitive to social stimuli, given their preference for social engagement. Utilizing event-related potential (ERP) methodology, this study demonstrates that variation on the extraversion dimension is associated with the extent to which social stimuli evoke enhanced allocation of attention. Specifically, higher scores on extraversion were found to be associated with higher amplitudes of the P300 component of the ERPs elicited by human faces. This finding suggests that social stimuli carry enhanced motivational significance for individuals characterized by high extraversion, and that individual differences in personality are related to meaningful individual differences in neural responses to social stimuli. PMID:21738558

  13. CLE Peptide Signaling and Crosstalk with Phytohormones and Environmental Stimuli.

    PubMed

    Wang, Guodong; Zhang, Guohua; Wu, Mengyao

    2015-01-01

    The CLE (CLAVATA3/Endosperm surrounding region-related) peptide family is one of the best-studied secreted peptide families in plants. Accumulated data have revealed that CLE genes play vital roles on stem cell homeostasis in different types of meristems. Additionally, CLE genes have been found to perform various biological roles in plant growth and development, and in response to environmental stimuli. With recent advances on our understanding of CLE peptide function, it is showing that the existence of potential crosstalks of CLE peptides with phytohormones and external stimuli. Complex interactions exist in which CLE petides coordinate with hormones to regulate plant growth and development, and in response to external stimuli. In this article, we present recent advances in cell-cell communication that is mediated by CLE peptides combining with phytohormones and external stimuli, and suggest additional Arabidopsis CLE genes that are likely to be controlled by hormones and environmental cues. PMID:26779239

  14. Prism adaptation contrasts perceptual habituation for repetitive somatosensory stimuli.

    PubMed

    Torta, D M; Tatu, M K; Cotroneo, D; Alamia, A; Folegatti, A; Trojan, J

    2016-03-01

    Prism adaptation (PA) is a non-invasive procedure that requires performing a visuo-motor pointing task while wearing prism goggles inducing a visual displacement of the pointed target. This procedure involves a reorganization of sensorimotor coordination, and induces long-lasting effects on numerous higher-order cognitive functions in healthy volunteers and neglect patients. Prismatic displacement (PD) of the visual field can be induced when prisms are worn but no sensorimotor task is required. In this case, it is unlikely that any subsequent reorganization takes place. The effects of PD are short-lived in the sense that they last as long as prisms are worn. In this study we aimed, to the best of our knowledge for the first time, at investigating whether PA and PD induce changes in the perception of intensity of nociceptive and non- nociceptive somatosensory stimuli. We induced, in healthy volunteers, PD (experiment 1), or PA (experiment 2) and asked participants to rate the intensity of the stimuli applied to the hand undergoing the visuo-proprioceptive conflict (experiment 1) or adaptation (experiment 2). Our results indicate that: 1) the visuo-proprioceptive conflict induced by PD does not reduce the perceived intensity of the stimuli, 2) PA prevents perceptual habituation for both nociceptive and non-nociceptive somatosensory stimuli. Moreover, to investigate the possible underlying mechanisms of the effects of PA we conducted a third experiment in which stimuli were applied both at the adapted and the non-adapted hand. In line with the results of experiment 2, we found that perceptual habituation was prevented for stimuli applied onto the adapted hand. Moreover, we observed the same finding for stimuli applied onto the non-adapted hand. This result suggests that the detention of habituation is not merely driven by changes in spatial attention allocation. Taken together, these data indicate that prisms can affect the perceived intensity of somatosensory stimuli

  15. Bayesian-based integration of multisensory naturalistic perithreshold stimuli.

    PubMed

    Regenbogen, Christina; Johansson, Emilia; Andersson, Patrik; Olsson, Mats J; Lundström, Johan N

    2016-07-29

    Most studies exploring multisensory integration have used clearly perceivable stimuli. According to the principle of inverse effectiveness, the added neural and behavioral benefit of integrating clear stimuli is reduced in comparison to stimuli with degraded and less salient unisensory information. Traditionally, speed and accuracy measures have been analyzed separately with few studies merging these to gain an understanding of speed-accuracy trade-offs in multisensory integration. In two separate experiments, we assessed multisensory integration of naturalistic audio-visual objects consisting of individually-tailored perithreshold dynamic visual and auditory stimuli, presented within a multiple-choice task, using a Bayesian Hierarchical Drift Diffusion Model that combines response time and accuracy. For both experiments, unisensory stimuli were degraded to reach a 75% identification accuracy level for all individuals and stimuli to promote multisensory binding. In Experiment 1, we subsequently presented uni- and their respective bimodal stimuli followed by a 5-alternative-forced-choice task. In Experiment 2, we controlled for low-level integration and attentional differences. Both experiments demonstrated significant superadditive multisensory integration of bimodal perithreshold dynamic information. We present evidence that the use of degraded sensory stimuli may provide a link between previous findings of inverse effectiveness on a single neuron level and overt behavior. We further suggest that a combined measure of accuracy and reaction time may be a more valid and holistic approach of studying multisensory integration and propose the application of drift diffusion models for studying behavioral correlates as well as brain-behavior relationships of multisensory integration. PMID:26719235

  16. siRNA Delivery by Stimuli-Sensitive Nanocarriers

    PubMed Central

    Salzano, Giuseppina; Costa, Daniel F.; Torchilin, Vladimir P.

    2016-01-01

    Since its discovery in late 1990s, small interfering RNA (siRNA) has become a significant biopharmaceutical research tool and a powerful option for the treatment of different human diseases based on altered gene-expression. Despite promising data from many pre-clinical studies, concrete hurdles still need to be overcome to bring therapeutic siRNAs in clinic. The design of stimuli-sensitive nanopreparations for gene therapy is a lively area of the current research. Compared to conventional systems for siRNA delivery, this type of platform can respond to local stimuli that are characteristics of the pathological area of interest, allowing the release of nucleic acids at the desired site. Acidic pH, abnormal levels of enzymes, altered redox potential and magnetic field are examples of stimuli exploited in the design of stimuli-sensitive nanoparticles. In this review, we discuss on recent stimuli-sensitive strategies for siRNA delivery and we highlight on the potential of combining multiple stimuli-sensitive strategies in the same nano-platform for a better therapeutic outcome. PMID:26486143

  17. Multisensory numerosity judgments for visual and tactile stimuli.

    PubMed

    Gallace, Alberto; Tan, Hong Z; Spence, Charles

    2007-05-01

    To date, numerosity judgments have been studied only under conditions of unimodal stimulus presentation. It is therefore unclear whether the same limitations on correctly reporting the number of unimodal visual or tactile stimuli presented in a display might be expected under conditions in which participants have to count stimuli presented simultaneously in two or more different sensory modalities. In Experiment 1, we investigated numerosity judgments using both unimodal and bimodal displays consisting of one to six vibrotactile stimuli (presented over the body surface) and one to six visual stimuli (seen on the body via mirror reflection). Participants had to count the number of stimuli regardless of their modality of presentation. Bimodal numerosity judgments were significantly less accurate than predicted on the basis of an independent modality-specific resources account, thus showing that numerosity judgments might rely on a unitary amodal system instead. The results of a second experiment demonstrated that divided attention costs could not account for the poor performance in the bimodal conditions of Experiment 1. We discuss these results in relation to current theories of cross-modal integration and to the cognitive resources and/or common higher order spatial representations possibly accessed by both visual and tactile stimuli. PMID:17727102

  18. Corticospinal Excitability Preceding the Grasping of Emotion-Laden Stimuli

    PubMed Central

    Nogueira-Campos, Anaelli Aparecida; de Oliveira, Laura Alice Santos; Della-Maggiore, Valeria; Esteves, Paula Oliveira; Rodrigues, Erika de Carvalho; D. Vargas, Claudia

    2014-01-01

    Evolutionary theories posit that emotions prime organisms for action. This study examined whether corticospinal excitability (CSE) is modulated by the emotional valence of a to-be-grasped stimulus. CSE was estimated based on the amplitude of motor evoked potentials (MEPs) elicited using transcranial magnetic stimulation (TMS) and recorded on the first dorsal interosseous (FDI) muscle. Participants were instructed to grasp (ACTION condition) or just look at (NO-ACTION condition) unpleasant, pleasant and neutral stimuli. TMS pulses were applied randomly at 500 or 250 ms before a go signal. MEP amplitudes were normalized within condition by computing a ratio for the emotion-laden stimuli by reference to the neutral stimuli. A divergent valence effect was observed in the ACTION condition, where the CSE ratio was higher during the preparation to grasp unpleasant compared to pleasant stimuli. In addition, the CSE ratio was lower for pleasant stimuli during the ACTION condition compared to the NO-ACTION condition. Altogether, these results indicate that motor preparation is selectively modulated by the valence of the stimulus to be grasped. The lower CSE for pleasant stimuli may result from the need to refrain from executing an imminent action. PMID:24732961

  19. The Impact of Stimuli on Affect in Persons With Dementia

    PubMed Central

    Cohen-Mansfield, Jiska; Marx, Marcia S.; Thein, Khin; Dakheel-Ali, Maha

    2011-01-01

    Objective To examine how presentation of different stimuli impacts affect in nursing home residents with dementia. Method Participants were 193 residents aged 60 to 101 years from 7 Maryland nursing homes who had a diagnosis of dementia (derived from the medical chart or obtained from the attending physician). Cognitive functioning was assessed via the Mini-Mental State Examination (MMSE), and data pertaining to activities of daily living were obtained through the Minimum Data Set. Affect was assessed using observations of the 5 moods from Lawton’s Modified Behavior Stream. Baseline observations of affect were performed for comparisons. During the study, each participant was presented with 25 predetermined engagement stimuli in random order over a period of 3 weeks. Stimuli were categorized as live social, simulated social, manipulative, work/task-related, music, reading, or individualized to the participant’s self-identity. The dates of data collection were 2005–2007. Results Differences between stimulus categories were significant for pleasure (F6,144 = 25.137, P < .001) and interest (F6,144 = 18.792, P < .001) but not for negative affect. Pleasure and interest were highest for the live social category, followed by self-identity and simulated social stimuli for pleasure, and for manipulative stimuli in terms of the effect on interest. The lowest levels of pleasure and interest were observed for music. Participants with higher cognitive function had significantly higher pleasure (F1,97 = 6.27, P < .05). Although the general trend of the impact of the different categories was similar for different levels of cognitive function, there were significant differences in pleasure in response to specific stimuli (interaction effect: F6,92 = 2.31, P < .05). Overall, social stimuli have the highest impact on affect in persons with dementia. Conclusions The findings of the present study are important, as affect is a major indicator of quality of life and this study is

  20. Central effects of acetylsalicylic acid on trigeminal-nociceptive stimuli

    PubMed Central

    2014-01-01

    Background Acetylsalicylic acid is one of the most used analgesics to treat an acute migraine attack. Next to the inhibitory effects on peripheral prostaglandin synthesis, central mechanisms of action have also been discussed. Methods Using a standardized model for trigeminal-nociceptive stimulation during fMRI scanning, we investigated the effect of acetylsalicylic acid on acute pain compared to saline in 22 healthy volunteers in a double-blind within-subject design. Painful stimulation was applied using gaseous ammonia and presented in a pseudo-randomized order with several control stimuli. All participants were instructed to rate the intensity and unpleasantness of every stimulus on a VAS scale. Based on previous results, we hypothesized to find an effect of ASA on central pain processing structures like the ACC, SI and SII as well as the trigeminal nuclei and the hypothalamus. Results Even though we did not find any differences in pain ratings between saline and ASA, we observed decreased BOLD signal changes in response to trigemino-nociceptive stimulation in the ACC and SII after administration of ASA compared to saline. This finding is in line with earlier imaging results investigating the effect of ASA on acute pain. Contrary to earlier findings from animal studies, we could not find an effect of ASA on the trigeminal nuclei in the brainstem or within the hypothalamic area. Conclusion Taken together our study replicates earlier findings of an attenuating effect of ASA on pain processing structures, which adds further evidence to a possibly central mechanism of action of ASA. PMID:25201152

  1. Sadness increases distraction by auditory deviant stimuli.

    PubMed

    Pacheco-Unguetti, Antonia P; Parmentier, Fabrice B R

    2014-02-01

    Research shows that attention is ineluctably captured away from a focal visual task by rare and unexpected changes (deviants) in an otherwise repeated stream of task-irrelevant auditory distractors (standards). The fundamental cognitive mechanisms underlying this effect have been the object of an increasing number of studies but their sensitivity to mood and emotions remains relatively unexplored despite suggestion of greater distractibility in negative emotional contexts. In this study, we examined the effect of sadness, a widespread form of emotional distress and a symptom of many disorders, on distraction by deviant sounds. Participants received either a sadness induction or a neutral mood induction by means of a mixed procedure based on music and autobiographical recall prior to taking part in an auditory-visual oddball task in which they categorized visual digits while ignoring task-irrelevant sounds. The results showed that although all participants exhibited significantly longer response times in the visual categorization task following the presentation of rare and unexpected deviant sounds relative to that of the standard sound, this distraction effect was significantly greater in participants who had received the sadness induction (a twofold increase). The residual distraction on the subsequent trial (postdeviance distraction) was equivalent in both groups, suggesting that sadness interfered with the disengagement of attention from the deviant sound and back toward the target stimulus. We propose that this disengagement impairment reflected the monopolization of cognitive resources by sadness and/or associated ruminations. Our findings suggest that sadness can increase distraction even when distractors are emotionally neutral. PMID:24098923

  2. Increased extracellular dopamine in the nucleus accumbens of the rat during associative learning of neutral stimuli.

    PubMed

    Young, A M; Ahier, R G; Upton, R L; Joseph, M H; Gray, J A

    1998-04-01

    Brain microdialysis was used to study changes in dopamine in the nucleus accumbens and the dorsal striatum during associative learning between two neutral stimuli, flashing light and tone, presented on a paired schedule during stage 1 of a sensory preconditioning paradigm. The tone was subsequently paired with mild footshock using standard aversive conditioning procedures and the formation of a conditioned association between the flashing light and the tone in stage 1 was assessed by measuring the ability of the flashing light to elicit the same conditioned response as the tone when presented at test. The first experiment used behavioural monitoring only, to establish stimulus parameters for subsequent microdialysis experiments. Animals receiving paired presentation of the light and tone in stage 1 showed a conditioned suppression of licking to the light as well as to the tone, indicating that associative learning between the flashing light and the tone had occurred during stage 1, whilst in a separate group of animals given the same stimuli over the same time period but on an explicitly non-paired schedule, the conditioned emotional response was seen to the tone, but not to the light, showing that no association had been formed between the two stimuli during stage 1. In dialysis experiments using the same procedure, we measured a two-fold rise in dopamine in the nucleus accumbens during paired presentation of flashing light and tone, but not during non-paired presentation of the two stimuli. On subsequent test presentation of the two stimuli, we saw increases in accumbal dopamine on presentation of the tone in both groups, reflecting the formation of an association with the footshock in both. However the flashing light elicited an increase in dopamine only in the group which had received paired presentation at stage 1. Thus accumbal dopamine release at test is correlated to the ability of the stimulus to evoke a conditioned response measured behaviourally

  3. Neural mechanisms by which gravitational stimuli and stress affect the secretion of renin and other hormones

    NASA Technical Reports Server (NTRS)

    Ganong, William F.

    1987-01-01

    The present goal is to determine by the production of discrete lesions the parts of the hypothalamus and brainstem that are involved in serotonin-mediated increases in renin secretion. A variety of stimuli which act in different ways to increase renin stimuli were developed and standardized. The experiments with p-chloroamphetamine (PCA) demonstrated that there is a serotonergic pathway which projects from the dorsal raphe nuclei to the paraventricular nuclei and the vetromedial nuclei of the hypothalamus; that projection from paraventricular nuclei to the brainstem and spinal cord may be oxytocinergic; and that the pathway from the spinal cord to the renin secreting cells is sympathetic. The demonstration that paraventicular lesions lower circulating renin substrate is important because it raises the possibility that substrate secretion is under neural control, either via the pituitary or by direct neural pathways. The discovery that lesions of the ventromedial nuclei appear to abolish the increase in renin secretion produced by many different stimuli without affecting the concentration of renin substrate in the plasma makes the position of the hypothalamus in the regulation of fluid and electrolyte balance more prominent than previously suspected.

  4. Opposite Distortions in Interval Timing Perception for Visual and Auditory Stimuli with Temporal Modulations

    PubMed Central

    Yuasa, Kenichi; Yotsumoto, Yuko

    2015-01-01

    When an object is presented visually and moves or flickers, the perception of its duration tends to be overestimated. Such an overestimation is called time dilation. Perceived time can also be distorted when a stimulus is presented aurally as an auditory flutter, but the mechanisms and their relationship to visual processing remains unclear. In the present study, we measured interval timing perception while modulating the temporal characteristics of visual and auditory stimuli, and investigated whether the interval times of visually and aurally presented objects shared a common mechanism. In these experiments, participants compared the durations of flickering or fluttering stimuli to standard stimuli, which were presented continuously. Perceived durations for auditory flutters were underestimated, while perceived durations of visual flickers were overestimated. When auditory flutters and visual flickers were presented simultaneously, these distortion effects were cancelled out. When auditory flutters were presented with a constantly presented visual stimulus, the interval timing perception of the visual stimulus was affected by the auditory flutters. These results indicate that interval timing perception is governed by independent mechanisms for visual and auditory processing, and that there are some interactions between the two processing systems. PMID:26292285

  5. Patient-Specific Simulations Reveal Significant Differences in Mechanical Stimuli in Venous and Arterial Coronary Grafts.

    PubMed

    Ramachandra, Abhay B; Kahn, Andrew M; Marsden, Alison L

    2016-08-01

    Mechanical stimuli are key to understanding disease progression and clinically observed differences in failure rates between arterial and venous grafts following coronary artery bypass graft surgery. We quantify biologically relevant mechanical stimuli, not available from standard imaging, in patient-specific simulations incorporating non-invasive clinical data. We couple CFD with closed-loop circulatory physiology models to quantify biologically relevant indices, including wall shear, oscillatory shear, and wall strain. We account for vessel-specific material properties in simulating vessel wall deformation. Wall shear was significantly lower (p = 0.014*) and atheroprone area significantly higher (p = 0.040*) in venous compared to arterial grafts. Wall strain in venous grafts was significantly lower (p = 0.003*) than in arterial grafts while no significant difference was observed in oscillatory shear index. Simulations demonstrate significant differences in mechanical stimuli acting on venous vs. arterial grafts, in line with clinically observed graft failure rates, offering a promising avenue for stratifying patients at risk for graft failure. PMID:27447176

  6. Electrodermal and behavioral responses of children with autism spectrum disorders to sensory and repetitive stimuli.

    PubMed

    McCormick, Carolyn; Hessl, David; Macari, Suzanne L; Ozonoff, Sally; Green, Cherie; Rogers, Sally J

    2014-08-01

    Parents frequently report that their children with autism spectrum disorders (ASD) respond atypically to sensory stimuli. Repetitive behaviors are also part of the ASD behavioral profile. Abnormal physiological arousal may underlie both of these symptoms. Electrodermal activity (EDA) is an index of sympathetic nervous system arousal. The goals of this study were twofold: (1) to pilot methods for collecting EDA data in young children and (2) to examine hypothesized relationships among EDA, and sensory symptoms and repetitive behaviors in children with ASD as compared with children with typical development. EDA was recorded on 54 young children with ASD and on 33 children with typical development (TD) during a protocol that included baseline, exposure to sensory and repetitive stimuli, and play. Parents completed standardized questionnaires regarding their child's sensory symptoms and repetitive behaviors. Frequency and type of repetitive behavior during play was coded offline. Comparisons between EDA data for ASD and TD groups indicated no significant between-group differences in any measures. Parents of children with ASD reported more abnormal responses to sensory stimuli and more repetitive behaviors, but scores on these measures were not significantly correlated with EDA or with frequency of observed repetitive behaviors. Parent report of frequency and severity of sensory symptoms was significantly correlated with reports of repetitive behaviors in both groups. Although parents of children with ASD report high levels of sensory symptoms and repetitive behaviors, these differences are not related to measured EDA arousal or reactivity. PMID:24788961

  7. Predicting Outcome in Comatose Patients: The Role of EEG Reactivity to Quantifiable Electrical Stimuli

    PubMed Central

    Liu, Gang; Su, Yingying; Liu, Yifei; Jiang, Mengdi; Zhang, Yan; Zhang, Yunzhou; Gao, Daiquan

    2016-01-01

    Objective. To test the value of quantifiable electrical stimuli as a reliable method to assess electroencephalogram reactivity (EEG-R) for the early prognostication of outcome in comatose patients. Methods. EEG was recorded in consecutive adults in coma after cardiopulmonary resuscitation (CPR) or stroke. EEG-R to standard electrical stimuli was tested. Each patient received a 3-month follow-up by the Glasgow-Pittsburgh cerebral performance categories (CPC) or modified Rankin scale (mRS) score. Results. Twenty-two patients met the inclusion criteria. In the CPR group, 6 of 7 patients with EEG-R had good outcomes (positive predictive value (PPV), 85.7%) and 4 of 5 patients without EEG-R had poor outcomes (negative predictive value (NPV), 80%). The sensitivity and specificity were 85.7% and 80%, respectively. In the stroke group, 6 of 7 patients with EEG-R had good outcomes (PPV, 85.7%); all of the 3 patients without EEG-R had poor outcomes (NPV, 100%). The sensitivity and specificity were 100% and 75%, respectively. Of all patients, the presence of EEG-R showed 92.3% sensitivity, 77.7% specificity, 85.7% PPV, and 87.5% NPV. Conclusion. EEG-R to quantifiable electrical stimuli might be a good positive predictive factor for the prognosis of outcome in comatose patients after CPR or stroke. PMID:27127529

  8. The New Boss!

    ERIC Educational Resources Information Center

    Harvey, Carl, II

    2012-01-01

    It happens--retirement , resignation, promotion, or relocation can bring a new principal on to the scene. In some ways, it is like starting a whole new job. Sure, the staff, students, and building have remained the same, but there is a whole new person in the front office to figure out and that one person can make a huge difference in the school…

  9. Corporate Boss, College President

    ERIC Educational Resources Information Center

    Alden, Vernon R.

    1978-01-01

    Differences between the roles of a corporate administrator and a college president are reviewed and related to the role of an effective trustee. It is noted that accountability demands affect institutional autonomy and that trustees must become more involved in policy-making to protect the academic freedom of colleges and universities in the…

  10. Who's the Boss?

    ERIC Educational Resources Information Center

    Bower, Bruce

    1986-01-01

    There is evidence that the conscious mind selects from among possible acts developed by the unconscious. Even lifting a finger may be subject to this shared mental management. Studies examining this point of view are summarized. (JN)

  11. Behavioral evidence showing the predominance of diffuse pain stimuli over discrete stimuli in influencing perception.

    PubMed

    Anderson, K V; Pearl, G S; Honeycutt, C

    1976-01-01

    This experiment was directed toward determining the relative effectiveness of discrete and diffuse pain stimuli in influencing perception and behavior. Shocks to the footpads were used to activate the discrete pain pathways and shocks to the upper canine teeth to activate the diffuse pain pathways. In the first phase of this experiment, cats were trained to escape from foot shock in a shuttle box. Current applied to the feet was varied in ascending and descending sequences for each animal according to the psychophysical method of limits and each animal was trained until stable thresholds for escape responding were achieved. In the second phase of the experiment, the effect on behavior of simultaneous activation of both the discrete and diffuse pain systems was assessed. The principal finding is this experiment was that excape responding that was well established when foot shock was presented alone was routinely abolished on trials when tooth shock and foot shock were presented together. These results were interpreted as indicating that the diffuse pain system was prepotent in influencing behavior when both the discrete and diffuse pain systems were activated simultaneously. PMID:1011300

  12. Stimuli-responsive smart nanogels for cancer diagnostics and therapy.

    PubMed

    Oishi, Motoi; Nagasaki, Yukio

    2010-04-01

    This article discusses stimuli-responsive poly(ethylene glycol) (PEG)-coated (PEGylated) nanogels and their biomedical applications. Preparation and characterization of stimuli-responsive PEGylated nanogels composed of a crosslinked poly(2-[N,N-diethylamino]ethyl methacrylate) (PEAMA) core and PEG tethered chains are initially described. Stimuli-responsive PEGylated nanogels show unique properties and functions in synchronizing with the reversible volume phase transition of the PEAMA core in response to the extracellular pH (7-6.5) of a tumor environment as well as endosomal/lysosomal pH (6.5-5.0) and temperature. We list several biomedical applications of stimuli-responsive PEGylated nanogels, including (19)F magnetic resonance spectroscopic imaging (MRS/I) probe to visualize acidosis (tumor tissue), intracellular drug and siRNA delivery, antennas for cancer photothermal therapy and apoptosis probe for monitoring response to cancer therapy. Thus, stimuli-responsive PEGylated nanogels can be utilized as smart nanomedicines for cancer diagnostics and therapy. PMID:20394537

  13. Effects of complex aural stimuli on mental performance.

    PubMed

    Vij, Mohit; Aghazadeh, Fereydoun; Ray, Thomas G; Hatipkarasulu, Selen

    2003-06-01

    The objective of this study is to investigate the effect of complex aural stimuli on mental performance. A series of experiments were designed to obtain data for two different analyses. The first analysis is a "Stimulus" versus "No-stimulus" comparison for each of the four dependent variables, i.e. quantitative ability, reasoning ability, spatial ability and memory of an individual, by comparing the control treatment with the rest of the treatments. The second set of analysis is a multi-variant analysis of variance for component level main effects and interactions. The two component factors are tempo of the complex aural stimuli and sound volume level, each administered at three discrete levels for all four dependent variables. Ten experiments were conducted on eleven subjects. It was found that complex aural stimuli influence the quantitative and spatial aspect of the mind, while the reasoning ability was unaffected by the stimuli. Although memory showed a trend to be worse with the presence of complex aural stimuli, the effect was statistically insignificant. Variation in tempo and sound volume level of an aural stimulus did not significantly affect the mental performance of an individual. The results of these experiments can be effectively used in designing work environments. PMID:15176128

  14. Protein-surface interactions on stimuli-responsive polymeric biomaterials.

    PubMed

    Cross, Michael C; Toomey, Ryan G; Gallant, Nathan D

    2016-04-01

    Responsive surfaces: a review of the dependence of protein adsorption on the reversible volume phase transition in stimuli-responsive polymers. Specifically addressed are a widely studied subset: thermoresponsive polymers. Findings are also generalizable to other materials which undergo a similarly reversible volume phase transition. As of 2015, over 100,000 articles have been published on stimuli-responsive polymers and many more on protein-biomaterial interactions. Significantly, fewer than 100 of these have focused specifically on protein interactions with stimuli-responsive polymers. These report a clear trend of increased protein adsorption in the collapsed state compared to the swollen state. This control over protein interactions makes stimuli-responsive polymers highly useful in biomedical applications such as wound repair scaffolds, on-demand drug delivery, and antifouling surfaces. Outstanding questions are whether the protein adsorption is reversible with the volume phase transition and whether there is a time-dependence. A clear understanding of protein interactions with stimuli-responsive polymers will advance theoretical models, experimental results, and biomedical applications. PMID:26942693

  15. Differing ERP patterns caused by suction and puff stimuli.

    PubMed

    Choi, Mi-Hyun; Kim, Hyung-Sik; Baek, Ji-Hye; Lee, Jung-Chul; Park, Sung-Jun; Jeong, Ul-Ho; Gim, Seon-Young; You, Ji Hye; Kim, Sung-Pil; Lim, Dae-Woon; Kim, Hyun-Jun; Chung, Soon-Cheol

    2015-05-01

    The present study compared event-related potential (ERP) patterns for two stimuli types, puff and suction, by applying these stimuli to the fingers; ERP patterns for the two stimuli were compared at C3, an area related to somatosensory perception, and at FC5, an area related to motor function. Participants were 12 healthy males in their 20s (mean age=23.1±2.0 years). One session consisted of a Control Phase (3s), a Stimulation Phase (3s), and a Rest Phase (9s). During the Stimulation Phase, a 4-psi suction or puff stimulus was applied to the first joint of the right index finger. After completion of the session, a subjective magnitude test was presented. In all phases, electroencephalography signals were recorded. We extracted maximum positive amplitude and minimum negative amplitude as well as relevant latency values for C3 and FC5 signals. Suction and puff stimuli had similar subjective magnitude scores. For both C3 and FC5, the maximum and minimum amplitude latency was reached earlier for the suction stimulus than for the puff stimulus. In conclusion, when suction and puff stimuli of the same intensity were applied to the fingers, the suction stimulus caused a more sensitive response in the somatosensory area (C3) and motor area (FC5) than did the puff stimulus. PMID:25823997

  16. The distinctiveness of ionic and nonionic bitter stimuli.

    PubMed

    Frank, Marion E; Bouverat, Brian P; MacKinnon, Bruce I; Hettinger, Thomas P

    2004-01-01

    The diverse chemical structures of stimuli that are bitter to humans suggest a need for multiple bitter receptors. Reactions of golden hamsters (Mesocricetus auratus) to 1 mM quinine hydrochloride, 3 mM denatonium benzoate, 180 mM magnesium sulfate, 30-100 mM caffeine, and 1-1.5 mM sucrose octaacetate (SOA) were studied to address whether there are multiple sensations elicited by bitter stimuli. Methods included behavioral generalization of LiCl-induced conditioned taste aversions (CTAs), intake preference tests, and electrophysiological recordings from the chorda tympani (CT) nerve. The five compounds, all bitter to humans, were all innately aversive to hamsters. CTA for the ionic quinine.HCl, denatonium benzoate, and MgSO(4) mutually cross-generalized and these ionic compounds were effective CT stimuli. Yet, the hamsters were much less sensitive to denatonium than humans, requiring a 100,000 times higher concentration for detection. CTA for nonionic caffeine and SOA did not cross-generalize to quinine or the other two ionic stimuli and these nonionic compounds were not effective CT stimuli. SOA and caffeine may elicit aversive reflexes or systemic reactions rather than taste sensations in the animals. Thus, the three ionic and two nonionic compounds form separate aversive stimulus classes in hamsters, neither of which appears to be a close homologue of the human bitter taste. PMID:14741226

  17. Stimuli responsive upconversion luminescence nanomaterials and films for various applications.

    PubMed

    Tsang, Ming-Kiu; Bai, Gongxun; Hao, Jianhua

    2015-03-21

    Upconversion luminescence (UCL) refers to nonlinear optical processes, which can convert near-infrared photons to short-wavelength emission. Recent advances in nanotechnology have contributed to the development of photon upconversion materials as promising new generation candidates of fluorescent bioprobes and spectral converters for biomedical and optoelectronic applications. Apart from the remarkable photoluminescence of the materials under photon excitation, some UCL materials may exhibit intrinsic magnetic, ferroelectric, X-ray absorption properties, and so on. These interesting characteristics provide an opportunity for us to couple a single stimulus or multiple stimuli (electric field, magnetic field, X-ray, electron beam, temperature and pH, etc.) to various types of UCL materials. In this review, we will primarily focus on the stimuli responsive properties of UCL materials beyond light-matter interaction, which can aid both fundamental research and widespread applications of the materials. The mechanisms of the response to various stimuli in the UCL materials are discussed. This article will also highlight recent advances in the development of these materials in response to various stimuli and their applications in multimodal bioimaging, drug delivery and release, electro-optical devices, magnetic, temperature and pH sensors and multiple anti-counterfeiting inks. Lastly, we will present potential directions of future research and challenging issues which arise in expanding the applications of stimuli responsive UCL materials. PMID:25200182

  18. Private Stimuli, Covert Responses, and Private Events: Conceptual Remarks

    PubMed Central

    Tourinho, Emmanuel Zagury

    2006-01-01

    In this article, I discuss the concepts of private stimuli, covert responses, and private events, emphasizing three aspects: the conditions under which private stimuli may acquire discriminative functions to verbal responses, the conditions of unobservability of covert responses, and the complexity of events or phenomena described as private. I argue that the role of private stimuli in the control of self-descriptive verbal responses is dependent on a relation (correlation or equivalence relation) with public stimuli, and that responses vary along a continuum of observability. These remarks on private stimuli and covert responses are introductory to an examination of the varying complexity of phenomena described as private. I argue that private events is a verbal response emitted under the control of phenomena of different degrees of complexity, and I interpret these phenomena, based on the principle of selection by consequences. I introduce the notion of inclusiveness to suggest that some phenomena related to privacy are less or more complex as they include relations of a phylogenetic, ontogenetic, and cultural origin. PMID:22478451

  19. Research trends of stimuli-responsive polymer hydrogels in Japan

    SciTech Connect

    Hirasa, O.

    1993-10-01

    In recent years, biological functions have been increasingly investigated on the molecular and/or atomic level. Synthesis and assemblies of various functional polymers have also been researched. In particular, research of stimuli-responsive polymeric materials having the function and efficiency of a biological system has been of interest. The materials are still in the embryonic period, but there are great expectations surrounding their progress. In this article, the research trends in Japan of stimuli-responsive polymer gel are summarized from the viewpoint of synthesis, fabrication, and applications. On synthesis, researches have been summarized on stimuli including light, heat or temperature, pH or ion, electric field, and chemicals. On fabrication, researches have been summarized on two types of fabrication methods: chemical methods, such as grafting and hybridization; and physical methods, such as blend, microgel, film, fiber and composite. On industrial applications, many attempts have been made in recent years concerning the released control of chemicals, especially drug delivery systems. Controls of adsorption, permeation, and enzyme reaction using stimuli-responsive polymer gels have also been attempted in the chemical engineering and bioengineering fields. On applications to actuators, the construction of some micro-actuating systems has been attempted. The stimuli-responsive polymer gels (chemomechanical gels) are very promising, both in the field of fundamental study and in the field of applied research.

  20. Evidence accumulation in a complex task: Making choices about concurrent multiattribute stimuli under time pressure.

    PubMed

    Palada, Hector; Neal, Andrew; Vuckovic, Anita; Martin, Russell; Samuels, Kate; Heathcote, Andrew

    2016-03-01

    Evidence accumulation models transform observed choices and associated response times into psychologically meaningful constructs such as the strength of evidence and the degree of caution. Standard versions of these models were developed for rapid (∼1 s) choices about simple stimuli, and have recently been elaborated to some degree to address more complex stimuli and response methods. However, these elaborations can be difficult to use with designs and measurements typically encountered in complex applied settings. We test the applicability of 2 standard accumulation models-the diffusion (Ratcliff & McKoon, 2008) and the linear ballistic accumulation (LBA) (Brown & Heathcote, 2008)-to data from a task representative of many applied situations: the detection of heterogeneous multiattribute targets in a simulated unmanned aerial vehicle (UAV) operator task. Despite responses taking more than 2 s and complications added by realistic features, such as a complex target classification rule, interruptions from a simultaneous UAV navigation task, and time pressured choices about several concurrently present potential targets, these models performed well descriptively. They also provided a coherent psychological explanation of the effects of decision uncertainty and workload manipulations. Our results support the wider application of standard evidence accumulation models to applied decision-making settings. PMID:26844369

  1. The P3 produced by auditory stimuli presented in a passive and active condition: modulation by visual stimuli.

    PubMed

    Wronka, Eligiusz; Kuniecki, Michał; Kaiser, Jan; Coenen, Anton M L

    2007-01-01

    The aim of this study was to investigate how the processing of auditory stimuli is affected by the simultaneous presentation of visual stimuli. This was approached in an active and passive condition, during which a P3 was elicited in the human EEG by single auditory stimuli. Subjects were presented tones, either alone or accompanied by the simultaneous exposition of pictures. There were two different sessions. In the first, the presented tones demanded no further cognitive activity from the subjects (passive or 'ignore' session), while in the second session subjects were instructed to count the tones (active or 'count' session). The central question was whether inter-modal influences of visual stimulation in the active condition would modulate the auditory P3 in the same way as in the passive condition. Brain responses in the ignore session revealed only a small P3-like component over the parietal and frontal cortex, however, when the auditory stimuli co-occurred with the visual stimuli, an increased frontal activity in the window of 300-500 ms was observed. This could be interpreted as the reflection of a more intensive involuntary attention shift, provoked by the preceding visual stimulation. Moreover, it was found that cognitive load caused by the count instruction, resulted in an evident P3, with maximal amplitude over parietal locations. This effect was smaller when auditory stimuli were presented on the visual background. These findings might support the thesis that available resources were assigned to the analysis of visual stimulus, and thus were not available to analyze the subsequent auditory stimuli. This reduction in allocation of resources for attention was restricted to the active condition only, when the matching of a template with incoming information results in a distinct P3 component. It is discussed whether the putative source of this effect is a change in the activity of the frontal cortex. PMID:17691223

  2. Effects of subliminal symbiotic stimuli on anxiety reduction.

    PubMed

    Malik, R; Krasney, M S; Aldworth, B; Ladd, H W

    1996-06-01

    The present study assessed the effectiveness of subliminal psychodynamic stimuli in reducing anxiety. 50 male and 50 female college students were tachistoscopically exposed to one of five stimuli: MOMMY AND I ARE ONE, DADDY AND I ARE ONE, I AM HAPPY WITH MYSELF, ONE, or a control stimulus MYMMO NAD I REA ENO. It was hypothesized that men would show a significant decrease in anxiety to the MOMMY stimulus, while women were expected to respond favorably to either the MOMMY or DADDY stimulus, or to both. Results showed that the subliminal stimuli did not produce differential effects on anxiety. This finding did not support previous claims for subliminal psychodynamic activation that the stimulation of symbiotic fantasy with the maternal figure produces positive behavioral effects. Despite this negative finding women's response to the MOMMY message was predicted by measures of self-perception. PMID:8774013

  3. Pedophilic brain potential responses to adult erotic stimuli.

    PubMed

    Knott, Verner; Impey, Danielle; Fisher, Derek; Delpero, Emily; Fedoroff, Paul

    2016-02-01

    Cognitive mechanisms associated with the relative lack of sexual interest in adults by pedophiles are poorly understood and may benefit from investigations examining how the brain processes adult erotic stimuli. The current study used event-related brain potentials (ERP) to investigate the time course of the explicit processing of erotic, emotional, and neutral pictures in 22 pedophilic patients and 22 healthy controls. Consistent with previous studies, early latency anterior ERP components were highly selective for erotic pictures. Although the ERPs elicited by emotional stimuli were similar in patients and controls, an early frontal positive (P2) component starting as early as 185 ms was significantly attenuated and slow to onset in pedophilia, and correlated with a clinical measure of cognitive distortions. Failure of rapid attentional capture by erotic stimuli suggests a relative reduction in early processing in pedophilic patients which may be associated with relatively diminished sexual interest in adults. PMID:26683083

  4. Stimuli-Responsive Nanomaterials for Therapeutic Protein Delivery

    PubMed Central

    Lu, Yue; Sun, Wujin; Gu, Zhen

    2014-01-01

    Protein therapeutics have emerged as a significant role in treatment of a broad spectrum of diseases, including cancer, metabolic disorders and autoimmune diseases. The efficacy of protein therapeutics, however, is limited by their instability, immunogenicity and short half-life. In order to overcome these barriers, tremendous efforts have recently been made in developing controlled protein delivery systems. Stimuli-triggered release is an appealing and promising approach for protein delivery and has made protein delivery with both spatiotemporal- and dosage-controlled manners possible. This review surveys recent advances in controlled protein delivery of proteins or peptides using stimuli-responsive nanomaterials. Strategies utilizing both physiological and external stimuli are introduced and discussed. PMID:25151983

  5. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: RSD measurement from the LOS-dependent power spectrum of DR12 BOSS galaxies

    NASA Astrophysics Data System (ADS)

    Gil-Marín, Héctor; Percival, Will J.; Brownstein, Joel R.; Chuang, Chia-Hsun; Grieb, Jan Niklas; Ho, Shirley; Kitaura, Francisco-Shu; Maraston, Claudia; Prada, Francisco; Rodríguez-Torres, Sergio; Ross, Ashley J.; Samushia, Lado; Schlegel, David J.; Thomas, Daniel; Tinker, Jeremy L.; Zhao, Gong-Bo

    2016-08-01

    We measure and analyse the clustering of the Baryon Oscillation Spectroscopic Survey (BOSS) relative to the line of sight (LOS), for LOWZ and CMASS galaxy samples drawn from the final Data Release 12. The LOWZ sample contains 361 762 galaxies with an effective redshift of zlowz = 0.32, and the CMASS sample 777 202 galaxies with an effective redshift of zcmass = 0.57. From the power spectrum monopole and quadrupole moments around the LOS, we measure the growth of structure parameter f times the amplitude of dark matter density fluctuations σ8 by modelling the redshift-space distortion signal. When the geometrical Alcock-Paczynski effect is also constrained from the same data, we find joint constraints on fσ8, the product of the Hubble constant and the comoving sound horizon at the baryon-drag epoch H(z)rs(zd), and the angular distance parameter divided by the sound horizon DA(z)/rs(zd). We find f(zlowz)σ8(zlowz) = 0.394 ± 0.062, DA(zlowz)/rs(zd) = 6.35 ± 0.19, H(zlowz)rs(zd) = (11.41 ± 0.56) 103 km s- 1 for the LOWZ sample, and f(zcmass)σ8(zcmass) = 0.444 ± 0.038, DA(zcmass)/rs(zd) = 9.42 ± 0.15, H(zcmass)rs(zd) = (13.92 ± 0.44) 103 km s- 1 for the CMASS sample. We find general agreement with previous BOSS DR11 measurements. Assuming the Hubble parameter and angular distance parameter are fixed at fiducial Λcold dark matter values, we find f(zlowz)σ8(zlowz) = 0.485 ± 0.044 and f(zcmass)σ8(zcmass) = 0.436 ± 0.022 for the LOWZ and CMASS samples, respectively.

  6. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: RSD measurement from the LOS-dependent power spectrum of DR12 BOSS galaxies

    NASA Astrophysics Data System (ADS)

    Gil-Marín, Héctor; Percival, Will J.; Brownstein, Joel R.; Chuang, Chia-Hsun; Grieb, Jan Niklas; Ho, Shirley; Shu Kitaura, Francisco-; Maraston, Claudia; Prada, Francisco; Rodríguez-Torres, Sergio; Ross, Ashley J.; Samushia, Lado; Schlegel, David J.; Thomas, Daniel; Tinker, Jeremy L.; Zhao, Gong-Bo

    2016-05-01

    We measure and analyse the clustering of the Baryon Oscillation Spectroscopic Survey (BOSS) relative to the line-of-sight (LOS), for LOWZ and CMASS galaxy samples drawn from the final Data Release 12 (DR12). The LOWZ sample contains 361 762 galaxies with an effective redshift of zlowz = 0.32, and the CMASS sample 777 202 galaxies with an effective redshift of zcmass = 0.57. From the power spectrum monopole and quadrupole moments around the LOS, we measure the growth of structure parameter f times the amplitude of dark matter density fluctuations σ8 by modeling the Redshift-Space Distortion signal. When the geometrical Alcock-Paczynski effect is also constrained from the same data, we find joint constraints on fσ8, the product of the Hubble constant and the comoving sound horizon at the baryon drag epoch H(z)rs(zd), and the angular distance parameter divided by the sound horizon DA(z)/rs(zd). We find f(zlowz)σ8(zlowz) = 0.394 ± 0.062, DA(zlowz)/rs(zd) = 6.35 ± 0.19, H(zlowz)rs(zd) = (11.41 ± 0.56) 103kms-1 for the LOWZ sample, and f(zcmass)σ8(zcmass) = 0.444 ± 0.038, DA(zcmass)/rs(zd) = 9.42 ± 0.15, H(z_cmass)r_s(z_d)=(13.92 ± 0.44) {10^3km}s^{-1} for the CMASS sample. We find general agreement with previous BOSS DR11 measurements. Assuming the Hubble parameter and angular distance parameter are fixed at fiducial ΛCDM values, we find f(zlowz)σ8(zlowz) = 0.485 ± 0.044 and f(zcmass)σ8(zcmass) = 0.436 ± 0.022 for the LOWZ and CMASS samples, respectively.

  7. The high-mass end of the red sequence at z ˜ 0.55 from SDSS-III/BOSS: completeness, bimodality and luminosity function

    NASA Astrophysics Data System (ADS)

    Montero-Dorta, Antonio D.; Bolton, Adam S.; Brownstein, Joel R.; Swanson, Molly; Dawson, Kyle; Prada, Francisco; Eisenstein, Daniel; Maraston, Claudia; Thomas, Daniel; Comparat, Johan; Chuang, Chia-Hsun; McBride, Cameron K.; Favole, Ginevra; Guo, Hong; Rodríguez-Torres, Sergio; Schneider, Donald P.

    2016-09-01

    We have developed an analytical method based on forward-modelling techniques to characterize the high-mass end of the red sequence (RS) galaxy population at redshift z ˜ 0.55, from the DR10 BOSS (Baryon Oscillation Spectroscopic Survey) CMASS spectroscopic sample, which comprises ˜600 000 galaxies. The method, which follows an unbinned maximum likelihood approach, allows the deconvolution of the intrinsic CMASS colour-colour-magnitude distributions from photometric errors and selection effects. This procedure requires modelling the covariance matrix for the i-band magnitude, g - r colour and r - i colour using Stripe 82 multi-epoch data. Our results indicate that the error-deconvolved intrinsic RS distribution is consistent, within the photometric uncertainties, with a single point (<0.05 mag) in the colour-colour plane at fixed magnitude, for a narrow redshift slice. We have computed the high-mass end (0.55Mi ≲ -22) of the 0.55i-band RS luminosity function (RS LF) in several redshift slices within the redshift range 0.52 < z < 0.63. In this narrow redshift range, the evolution of the RS LF is consistent, within the uncertainties in the modelling, with a passively evolving model with Φ* = (7.248 ± 0.204) × 10- 4 Mpc-3 mag-1, fading at a rate of 1.5 ± 0.4 mag per unit redshift. We report RS completeness as a function of magnitude and redshift in the CMASS sample, which will facilitate a variety of galaxy-evolution and clustering studies using BOSS. Our forward-modelling method lays the foundations for future studies using other dark-energy surveys like the Extended Baryon Oscillation Spectroscopic Survey or the Dark Energy Spectroscopic Instrument, which are affected by the same type of photometric blurring/selection effects.

  8. Constraint on the time variation of the fine-structure constant with the SDSS-III/BOSS DR12 quasar sample

    NASA Astrophysics Data System (ADS)

    Albareti, Franco D.; Comparat, Johan; Gutiérrez, Carlos M.; Prada, Francisco; Pâris, Isabelle; Schlegel, David; López-Corredoira, Martín; Schneider, Donald P.; Manchado, Arturo; García-Hernández, D. A.; Petitjean, Patrick; Ge, Jian

    2015-10-01

    From the Sloan Digital Sky Survey (SDSS) Data Release 12, which covers the full Baryonic Oscillation Spectroscopic Survey (BOSS) footprint, we investigate the possible variation of the fine-structure constant over cosmological time-scales. We analyse the largest quasar sample considered so far in the literature, which contains 13 175 spectra (10 363 from SDSS-III/BOSS DR12 + 2812 from SDSS-II DR7) with redshift z < 1. We apply the emission-line method on the [O III] doublet (λλ 4960, 5008 Å) and obtain Δα/α = (0.9 ± 1.8) × 10-5 for the relative variation of the fine-structure constant. We also investigate the possible sources of systematics: misidentification of the lines, sky OH lines, H β and broad line contamination, Gaussian and Voigt fitting profiles, optimal wavelength range for the Gaussian fits, chosen polynomial order for the continuum spectrum, signal-to-noise ratio and good quality of the fits. The uncertainty of the measurement is dominated by the sky subtraction. The results presented in this work, being systematics limited, have sufficient statistics to constrain robustly the variation of the fine-structure constant in redshift bins (Δz ≈ 0.06) over the last 7.9 Gyr. In addition, we study the [Ne III] doublet (λλ 3869, 3968 Å) present in 462 quasar spectra and discuss the systematic effects on using these emission lines to constrain the fine-structure constant variation. Better constraints on Δα/α (< 10-6) using the emission-line method would be possible with high-resolution spectroscopy and large galaxy/qso surveys.

  9. Sex-Specific Content Preferences for Visual Sexual Stimuli

    PubMed Central

    Rupp, Heather A.; Wallen, Kim

    2009-01-01

    Although experimental studies support that men generally respond more to visual sexual stimuli than do women, there is substantial variability in this effect. One potential source of variability is the type of stimuli used that may not be of equal interest to both men and women whose preferences may be dependent upon the activities and situations depicted. The current study investigated whether men and women had preferences for certain types of stimuli. We measured the subjective evaluations and viewing times of 15 men and 30 women (15 using hormonal contraception) to sexually explicit photos. Heterosexual participants viewed 216 pictures that were controlled for the sexual activity depicted, gaze of the female actor, and the proportion of the image that the genital region occupied. Men and women did not differ in their overall interest in the stimuli, indicated by equal subjective ratings and viewing times, although there were preferences for specific types of pictures. Pictures of the opposite sex receiving oral sex were rated as least sexually attractive by all participants and they looked longer at pictures showing the female actor’s body. Women rated pictures in which the female actor was looking indirectly at the camera as more attractive, while men did not discriminate by female gaze. Participants did not look as long at close-ups of genitals, and men and women on oral contraceptives rated genital images as less sexually attractive. Together, these data demonstrate sex-specific preferences for specific types of stimuli even when, across stimuli, overall interest was comparable. PMID:18719987

  10. Adaptation of spatiotemporal mechanisms by increment and decrement stimuli

    NASA Astrophysics Data System (ADS)

    Purkiss, Todd J.; Demarco, Paul J.

    2002-08-01

    Sawtooth modulation has been used in the past to examine visual sensitivity to luminance increments and decrements. The threshold elevation caused by adaptation depends on the spatial profile of the stimulus field and the polarities of the adaptation and test stimuli. We hypothesized that the adaptation effects reflect a change in the sensitivity of the spatiotemporal channels that detect the stimuli. We used a 2-deg disk centered in a larger surround field. Five levels of contrast between the test field and surround were investigated: equiluminant, three intermediate levels, and dark. At each contrast, observers adapted for 5 s to 2-Hz sawtooth modulation (rapid-on or rapid-off). Immediately after adaptation, thresholds were measured for detection of a single cycle of either a rapid-on or a rapid-off waveform. Varying the contrast of the surround affected observers sensitivity to the polarity of the sawtooth stimulus to the extent that the pattern of sensitivity with the equiluminant surround was the opposite of that with the dark surround. To examine temporal factors, we measured thresholds for slow (500-ms ramps) and fast (8.3-ms pulses) test stimuli. The adaptation effect was preserved with the ramp stimuli but not with the pulse stimuli. Blurring the edge between the test and surround fields in the equiluminant surround condition raised thresholds for all sawtooth test stimuli, suggesting that spatiotemporal channels sensitive to high spatial frequencies and low temporal frequencies facilitate detection in that condition. These findings suggest that adaptation to sawtooth modulation can differentially effect the sensitivity of ON and OFF pathways, but the relative desensitization of each pathway depends on an interaction with the adaptation state of spatiotemporal channels that are involved in detection. 2002 Optical Society of America

  11. Cognitive robotic system for learning of complex visual stimuli

    NASA Astrophysics Data System (ADS)

    Potapov, A. S.; Rozhkov, A. S.

    2013-05-01

    The problem of learning of complex visual stimuli in cognitive robotics is considered. These stimuli should be selected on the base of rules supporting arbitrary comparisons of stimulus features with features of other salient objects (context). New perceptual knowledge representation based on the predicate logic is implemented to express such rules. Computable predicates are provided by low-level vision system. The rules are constructed using genetic algorithms on the base of a set of examples obtained by a robot during consequent trials. Dependence between the number of necessary trials and rule complexity is studied.

  12. Emerging applications of stimuli-responsive polymer materials

    NASA Astrophysics Data System (ADS)

    Stuart, Martien A. Cohen; Huck, Wilhelm T. S.; Genzer, Jan; Müller, Marcus; Ober, Christopher; Stamm, Manfred; Sukhorukov, Gleb B.; Szleifer, Igal; Tsukruk, Vladimir V.; Urban, Marek; Winnik, Françoise; Zauscher, Stefan; Luzinov, Igor; Minko, Sergiy

    2010-02-01

    Responsive polymer materials can adapt to surrounding environments, regulate transport of ions and molecules, change wettability and adhesion of different species on external stimuli, or convert chemical and biochemical signals into optical, electrical, thermal and mechanical signals, and vice versa. These materials are playing an increasingly important part in a diverse range of applications, such as drug delivery, diagnostics, tissue engineering and 'smart' optical systems, as well as biosensors, microelectromechanical systems, coatings and textiles. We review recent advances and challenges in the developments towards applications of stimuli-responsive polymeric materials that are self-assembled from nanostructured building blocks. We also provide a critical outline of emerging developments.

  13. Orienting Toward Face-Like Stimuli in Early Childhood.

    PubMed

    Shah, Punit; Happé, Francesca; Sowden, Sophie; Cook, Richard; Bird, Geoffrey

    2015-01-01

    Newborn infants orient preferentially toward face-like or "protoface" stimuli and recent studies suggest similar reflexive orienting responses in adults. Little is known, however, about the operation of this mechanism in childhood. An attentional-cueing procedure was therefore developed to investigate protoface orienting in early childhood. Consistent with the extant literature, 5- to 6-year-old children (n = 25) exhibited orienting toward face-like stimuli; they responded faster when target location was cued by the appearance of a protoface stimulus than when location was cued by matched control patterns. The potential of this procedure to investigate the development of typical and atypical social perception is discussed. PMID:26435013

  14. OLFACTORY EVOKED RESPONSES TO ODOROUS STIMULI OF DIFFERENT INTENSITIES

    EPA Science Inventory

    In comparison to other senses the electrophysiology of olfaction has been little studied in man and some of the basic paradigms used in the study of the other senses have not yet been widely applied to its study. asic information such as the effect of stimuli of different intensi...

  15. Submillisecond unmasked subliminal visual stimuli evoke electrical brain responses.

    PubMed

    Sperdin, Holger F; Spierer, Lucas; Becker, Robert; Michel, Christoph M; Landis, Theodor

    2015-04-01

    Subliminal perception is strongly associated to the processing of meaningful or emotional information and has mostly been studied using visual masking. In this study, we used high density 256-channel EEG coupled with an liquid crystal display (LCD) tachistoscope to characterize the spatio-temporal dynamics of the brain response to visual checkerboard stimuli (Experiment 1) or blank stimuli (Experiment 2) presented without a mask for 1 ms (visible), 500 µs (partially visible), and 250 µs (subliminal) by applying time-wise, assumption-free nonparametric randomization statistics on the strength and on the topography of high-density scalp-recorded electric field. Stimulus visibility was assessed in a third separate behavioral experiment. Results revealed that unmasked checkerboards presented subliminally for 250 µs evoked weak but detectable visual evoked potential (VEP) responses. When the checkerboards were replaced by blank stimuli, there was no evidence for the presence of an evoked response anymore. Furthermore, the checkerboard VEPs were modulated topographically between 243 and 296 ms post-stimulus onset as a function of stimulus duration, indicative of the engagement of distinct configuration of active brain networks. A distributed electrical source analysis localized this modulation within the right superior parietal lobule near the precuneus. These results show the presence of a brain response to submillisecond unmasked subliminal visual stimuli independently of their emotional saliency or meaningfulness and opens an avenue for new investigations of subliminal stimulation without using visual masking. PMID:25487054

  16. A Study of the Affective Responses Elicited by Occupational Stimuli

    ERIC Educational Resources Information Center

    Schoon, Craig G.

    1976-01-01

    The semantic differential was used to assess the properties of affect elicited by occupational stimuli. Vocationally committed men studying medicine, business, and engineering responded to a semantic differential containing occupational concepts. Results show a semantic space for all three groups composed of three orthogonal dimensions of affect…

  17. Slowed response to peripheral visual stimuli during strenuous exercise.

    PubMed

    Ando, Soichi; Komiyama, Takaaki; Kokubu, Masahiro; Sudo, Mizuki; Kiyonaga, Akira; Tanaka, Hiroaki; Higaki, Yasuki

    2016-07-01

    Recently, we proposed that strenuous exercise impairs peripheral visual perception because visual responses to peripheral visual stimuli were slowed during strenuous exercise. However, this proposal was challenged because strenuous exercise is also likely to affect the brain network underlying motor responses. The purpose of the current study was to resolve this issue. Fourteen participants performed a visual reaction-time (RT) task at rest and while exercising at 50% (moderate) and 75% (strenuous) peak oxygen uptake. Visual stimuli were randomly presented at different distances from fixation in two task conditions: the Central condition (2° or 5° from fixation) and the Peripheral condition (30° or 50° from fixation). We defined premotor time as the time between stimulus onset and the motor response, as determined using electromyographic recordings. In the Central condition, premotor time did not change during moderate (167±19ms) and strenuous (168±24ms) exercise from that at rest (164±17ms). In the Peripheral condition, premotor time significantly increased during moderate (181±18ms, P<0.05) and strenuous exercise (189±23ms, P<0.001) from that at rest (173±17ms). These results suggest that increases in Premotor Time to the peripheral visual stimuli did not result from an impaired motor-response network, but rather from impaired peripheral visual perception. We conclude that slowed response to peripheral visual stimuli during strenuous exercise primarily results from impaired visual perception of the periphery. PMID:27080081

  18. Probability of Equivalence Formation: Familiar Stimuli and Training Sequence

    ERIC Educational Resources Information Center

    Arntzen, Erik

    2004-01-01

    The present study was conducted to show how responding in accord with equivalence relations changes as a function of position of familiar stimuli, pictures, and with the use of nonsense syllables in an MTO-training structure. Fifty college students were tested for responding in accord with equivalence in an AB, CB, DB, and EB training structure.…

  19. Developmental Complexity of the Stimuli Included in Mispronunciation Detection Tasks

    ERIC Educational Resources Information Center

    McNeill, Brigid C.; Hesketh, Anne

    2010-01-01

    Background: Phonological representations are important for speech and literacy development. Mispronunciation detection tasks have been proposed as an appropriate measure of phonological representations for children with speech disorder. There has been limited analysis, however, of the developmental complexity of task stimuli. Further, the tasks…

  20. Gradient Shifts with Naturally Occurring Human Face Stimuli

    ERIC Educational Resources Information Center

    Derenne, Adam; Breitstein, R. Michael

    2006-01-01

    The present research examined stimulus generalization and gradient shifts on a dimension involving human faces. Twenty undergraduates were instructed to examine the proportion of the total face length that lay between the tip of the nose and the end of the chin. The face stimuli were images of actual people shown on a computer screen; no face was…

  1. Delivery of continuously-varying stimuli using channelrhodopsin-2

    PubMed Central

    Tchumatchenko, Tatjana; Newman, Jonathan P.; Fong, Ming-fai; Potter, Steve M.

    2013-01-01

    To study sensory processing, stimuli are delivered to the sensory organs of animals and evoked neural activity is recorded downstream. However, noise and uncontrolled modulatory input can interfere with repeatable delivery of sensory stimuli to higher brain regions. Here we show how channelrhodopsin-2 (ChR2) can be used to deliver continuous, subthreshold, time-varying currents to neurons at any point along the sensory-motor pathway. To do this, we first deduce the frequency response function of ChR2 using a Markov model of channel kinetics. We then confirm ChR2's frequency response characteristics using continuously-varying optical stimulation of neurons that express one of three ChR2 variants. We find that wild-type ChR2 and the E123T/H134R mutant (“ChETA”) can pass continuously-varying subthreshold stimuli with frequencies up to ~70 Hz. Additionally, we find that wild-type ChR2 exhibits a strong resonance at ~6–10 Hz. Together, these results indicate that ChR2-derived optogenetic tools are useful for delivering highly repeatable artificial stimuli that mimic in vivo synaptic bombardment. PMID:24367294

  2. Influence of simultaneous gustatory stimuli on orthonasal and retronasal olfaction.

    PubMed

    Welge-Lüssen, Antje; Husner, Alexander; Wolfensberger, Markus; Hummel, Thomas

    2009-04-24

    Orthonasal and retronasal olfaction processes differ. The aim of this study was to examine whether congruent and incongruent simultaneous gustatory stimuli influence orthonasal and retronasal odorant perception, using olfactory event-related potentials as a measure. Thirty-two young, healthy subjects (16 men, 16 women) took part in two test sessions. Olfactory event-related potentials were recorded in response to a food-like odor, vanillin, and to an odor usually not associated with foods, the rose-like phenylethylalcohol. Each session consisted of four randomized blocks of 15 stimuli each which were applied either orthonasally or retronasally. Simultaneously, sweet or sour gustatory stimuli were applied. In response to retronasal vanillin, stimuli latencies P2 of the event-related potentials were significantly shorter in the congruent "sweet condition" than the incongruent "sour condition". In contrast, with orthonasal stimulation, shorter P2 latencies were seen for both odorants in the incongruent condition. Intensity of both odorants was perceived as less pronounced after retronasal stimulation than after orthonasal stimulation. In conclusion, application of a sweet taste significantly enhanced the processing of a congruent olfactory stimulus when presented through the retronasal route. Incongruent simultaneous gustatory stimulation applied during orthonasal olfaction seemed to induce conflict priming, also resulting in faster processing. PMID:19429068

  3. Integration of auditory and vibrotactile stimuli: Effects of frequency

    PubMed Central

    Wilson, E. Courtenay; Reed, Charlotte M.; Braida, Louis D.

    2010-01-01

    Perceptual integration of vibrotactile and auditory sinusoidal tone pulses was studied in detection experiments as a function of stimulation frequency. Vibrotactile stimuli were delivered through a single channel vibrator to the left middle fingertip. Auditory stimuli were presented diotically through headphones in a background of 50 dB sound pressure level broadband noise. Detection performance for combined auditory-tactile presentations was measured using stimulus levels that yielded 63% to 77% correct unimodal performance. In Experiment 1, the vibrotactile stimulus was 250 Hz and the auditory stimulus varied between 125 and 2000 Hz. In Experiment 2, the auditory stimulus was 250 Hz and the tactile stimulus varied between 50 and 400 Hz. In Experiment 3, the auditory and tactile stimuli were always equal in frequency and ranged from 50 to 400 Hz. The highest rates of detection for the combined-modality stimulus were obtained when stimulating frequencies in the two modalities were equal or closely spaced (and within the Pacinian range). Combined-modality detection for closely spaced frequencies was generally consistent with an algebraic sum model of perceptual integration; wider-frequency spacings were generally better fit by a Pythagorean sum model. Thus, perceptual integration of auditory and tactile stimuli at near-threshold levels appears to depend both on absolute frequency and relative frequency of stimulation within each modality. PMID:21117754

  4. Infants' Preferential Attention to Sung and Spoken Stimuli

    ERIC Educational Resources Information Center

    Costa-Giomi, Eugenia; Ilari, Beatriz

    2014-01-01

    Caregivers and early childhood teachers all over the world use singing and speech to elicit and maintain infants' attention. Research comparing infants' preferential attention to music and speech is inconclusive regarding their responses to these two types of auditory stimuli, with one study showing a music bias and another one…

  5. Impaired Prioritization of Novel Onset Stimuli in Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Keehn, Brandon; Joseph, Robert M.

    2008-01-01

    Background: Deficiency in the adaptive allocation of attention to relevant environmental stimuli is an associated feature of autism spectrum disorder (ASD). Recent evidence suggests that individuals with ASD may be specifically impaired in attentional prioritization of novel onsets. Method: We investigated modulation of attention by novel onset…

  6. Updating Positive and Negative Stimuli in Working Memory in Depression

    ERIC Educational Resources Information Center

    Levens, Sara M.; Gotlib, Ian H.

    2010-01-01

    Difficulties in the ability to update stimuli in working memory (WM) may underlie the problems with regulating emotions that lead to the development and perpetuation of mood disorders such as depression. To examine the ability to update affective material in WM, the authors had diagnosed depressed and never-disordered control participants perform…

  7. Stress improves selective attention towards emotionally neutral left ear stimuli.

    PubMed

    Hoskin, Robert; Hunter, M D; Woodruff, P W R

    2014-09-01

    Research concerning the impact of psychological stress on visual selective attention has produced mixed results. The current paper describes two experiments which utilise a novel auditory oddball paradigm to test the impact of psychological stress on auditory selective attention. Participants had to report the location of emotionally-neutral auditory stimuli, while ignoring task-irrelevant changes in their content. The results of the first experiment, in which speech stimuli were presented, suggested that stress improves the ability to selectively attend to left, but not right ear stimuli. When this experiment was repeated using tonal stimuli the same result was evident, but only for female participants. Females were also found to experience greater levels of distraction in general across the two experiments. These findings support the goal-shielding theory which suggests that stress improves selective attention by reducing the attentional resources available to process task-irrelevant information. The study also demonstrates, for the first time, that this goal-shielding effect extends to auditory perception. PMID:25086222

  8. Motor commands induce time compression for tactile stimuli.

    PubMed

    Tomassini, Alice; Gori, Monica; Baud-Bovy, Gabriel; Sandini, Giulio; Morrone, Maria Concetta

    2014-07-01

    Saccades cause compression of visual space around the saccadic target, and also a compression of time, both phenomena thought to be related to the problem of maintaining saccadic stability (Morrone et al., 2005; Burr and Morrone, 2011). Interestingly, similar phenomena occur at the time of hand movements, when tactile stimuli are systematically mislocalized in the direction of the movement (Dassonville, 1995; Watanabe et al., 2009). In this study, we measured whether hand movements also cause an alteration of the perceived timing of tactile signals. Human participants compared the temporal separation between two pairs of tactile taps while moving their right hand in response to an auditory cue. The first pair of tactile taps was presented at variable times with respect to movement with a fixed onset asynchrony of 150 ms. Two seconds after test presentation, when the hand was stationary, the second pair of taps was delivered with a variable temporal separation. Tactile stimuli could be delivered to either the right moving or left stationary hand. When the tactile stimuli were presented to the motor effector just before and during movement, their perceived temporal separation was reduced. The time compression was effector-specific, as perceived time was veridical for the left stationary hand. The results indicate that time intervals are compressed around the time of hand movements. As for vision, the mislocalizations of time and space for touch stimuli may be consequences of a mechanism attempting to achieve perceptual stability during tactile exploration of objects, suggesting common strategies within different sensorimotor systems. PMID:24990936

  9. Positive mood broadens visual attention to positive stimuli

    PubMed Central

    Wadlinger, Heather A.; Isaacowitz, Derek M.

    2010-01-01

    In an attempt to investigate the impact of positive emotions on visual attention within the context of Fredrickson's (1998) broaden-and-build model, eye tracking was used in two studies to measure visual attentional preferences of college students (n=58, n=26) to emotional pictures. Half of each sample experienced induced positive mood immediately before viewing slides of three similarly-valenced images, in varying central-peripheral arrays. Attentional breadth was determined by measuring the percentage viewing time to peripheral images as well as by the number of visual saccades participants made per slide. Consistent with Fredrickson's theory, the first study showed that individuals induced into positive mood fixated more on peripheral stimuli than did control participants; however, this only held true for highly-valenced positive stimuli. Participants under induced positive mood also made more frequent saccades for slides of neutral and positive valence. A second study showed that these effects were not simply due to differences in emotional arousal between stimuli. Selective attentional broadening to positive stimuli may act both to facilitate later building of resources as well as to maintain current positive affective states. PMID:20431711

  10. Auditory Long Latency Responses to Tonal and Speech Stimuli

    ERIC Educational Resources Information Center

    Swink, Shannon; Stuart, Andrew

    2012-01-01

    Purpose: The effects of type of stimuli (i.e., nonspeech vs. speech), speech (i.e., natural vs. synthetic), gender of speaker and listener, speaker (i.e., self vs. other), and frequency alteration in self-produced speech on the late auditory cortical evoked potential were examined. Method: Young adult men (n = 15) and women (n = 15), all with…

  11. Tagging Multiple Emotional Stimuli: Negative Valence Has Little Benefit

    ERIC Educational Resources Information Center

    Watson, Derrick G.; Blagrove, Elisabeth

    2012-01-01

    Six experiments examined the influence of emotional valence on the tagging and enumeration of multiple targets. Experiments 1, 5 and 6 found that there was no difference in the efficiency of tagging/enumerating multiple negative or positive stimuli. Experiment 2 showed that, when neutral-expression face distractors were present, enumerating…

  12. Superior Detection of Threat-Relevant Stimuli in Infancy

    ERIC Educational Resources Information Center

    LoBue, Vanessa; DeLoache, Judy S.

    2010-01-01

    The ability to quickly detect potential threat is an important survival mechanism for humans and other animals. Past research has established that adults have an attentional bias for the detection of threat-relevant stimuli, including snakes and spiders as well as angry human faces. Recent studies have documented that preschool children also…

  13. Attentional control of the processing of neural and emotional stimuli.

    PubMed

    Pessoa, Luiz; Kastner, Sabine; Ungerleider, Leslie G

    2002-12-01

    A typical scene contains many different objects that compete for neural representation due to the limited processing capacity of the visual system. At the neural level, competition among multiple stimuli is evidenced by the mutual suppression of their visually evoked responses and occurs most strongly at the level of the receptive field. The competition among multiple objects can be biased by both bottom-up sensory-driven mechanisms and top-down influences, such as selective attention. Functional brain imaging studies reveal that biasing signals due to selective attention can modulate neural activity in visual cortex not only in the presence but also in the absence of visual stimulation. Although the competition among stimuli for representation is ultimately resolved within visual cortex, the source of top-down biasing signals likely derives from a distributed network of areas in frontal and parietal cortex. Competition suggests that once attentional resources are depleted, no further processing is possible. Yet, existing data suggest that emotional stimuli activate brain regions "automatically," largely immune from attentional control. We tested the alternative possibility, namely, that the neural processing of stimuli with emotional content is not automatic and instead requires some degree of attention. Our results revealed that, contrary to the prevailing view, all brain regions responding differentially to emotional faces, including the amygdala, did so only when sufficient attentional resources were available to process the faces. Thus, similar to the processing of other stimulus categories, the processing of facial expression is under top-down control. PMID:12433381

  14. Alliesthesia to food cues: heterogeneity across stimuli and sensory modalities.

    PubMed

    Jiang, Tao; Soussignan, Robert; Rigaud, Daniel; Martin, Sylviane; Royet, Jean-Pierre; Brondel, Laurent; Schaal, Benoist

    2008-10-20

    Negative alliesthesia to olfactory and visual stimuli was assessed in 29 normal-weight women who, on alternate days, were either fasting or in a postprandial state after an ad libitum lunch. The participants were alternatively exposed to food and non-food pictures and odorants, and then rated for their hedonic appreciation (liking) and their desire to ingest (wanting) the evoked foods. While negative alliesthesia was observed only for food stimuli, it did not equally affect all food categories in either sensory modality. The stimuli representing foods eaten in typical local main dishes or having high energy density (e.g., pizza, bacon, beef, cheese) evoked clear negative alliesthesia, whereas this was not the case for those less consumed within a customary meal or associated with desserts (i.e., fruits). Furthermore, the visual food stimuli triggered a more negative shift in liking than did the food odours. Finally, the shift in wanting between pre- and post-meal state was more important than the shift in liking. These results suggest that alliesthesia may be influenced by both metabolic and non-metabolic factors. PMID:18675834

  15. Spatiotemporal dynamics of random stimuli account for trial-to-trial variability in perceptual decision making

    PubMed Central

    Park, Hame; Lueckmann, Jan-Matthis; von Kriegstein, Katharina; Bitzer, Sebastian; Kiebel, Stefan J.

    2016-01-01

    Decisions in everyday life are prone to error. Standard models typically assume that errors during perceptual decisions are due to noise. However, it is unclear how noise in the sensory input affects the decision. Here we show that there are experimental tasks for which one can analyse the exact spatio-temporal details of a dynamic sensory noise and better understand variability in human perceptual decisions. Using a new experimental visual tracking task and a novel Bayesian decision making model, we found that the spatio-temporal noise fluctuations in the input of single trials explain a significant part of the observed responses. Our results show that modelling the precise internal representations of human participants helps predict when perceptual decisions go wrong. Furthermore, by modelling precisely the stimuli at the single-trial level, we were able to identify the underlying mechanism of perceptual decision making in more detail than standard models. PMID:26752272

  16. Intermodal transfer in temporal discrimination. [of visual and acoustic stimuli duration

    NASA Technical Reports Server (NTRS)

    Warm, J. S.; Stutz, R. M.; Vassolo, P. A.

    1975-01-01

    This study determined if training for accuracy in temporal discrimination would transfer across sensory modalities. A fractionation method was used in which subjects bisected the durations of acoustic and visual signals at three standard intervals (6, 12, and 18 sec). Absolute error was the performance index. Half of the subjects were trained with acoustic stimuli and then tested in vision; the remainder were trained in vision and tested in audition. Similar negatively accelerated acquisition functions were noted for both modalities. Positive intermodal transfer, characterized by symmetry across modalities, was obtained at all standard durations. The results were considered to provide support for the notion that a common mechanism underlies temporal discriminations in different sensory systems.

  17. Spatiotemporal dynamics of random stimuli account for trial-to-trial variability in perceptual decision making.

    PubMed

    Park, Hame; Lueckmann, Jan-Matthis; von Kriegstein, Katharina; Bitzer, Sebastian; Kiebel, Stefan J

    2016-01-01

    Decisions in everyday life are prone to error. Standard models typically assume that errors during perceptual decisions are due to noise. However, it is unclear how noise in the sensory input affects the decision. Here we show that there are experimental tasks for which one can analyse the exact spatio-temporal details of a dynamic sensory noise and better understand variability in human perceptual decisions. Using a new experimental visual tracking task and a novel Bayesian decision making model, we found that the spatio-temporal noise fluctuations in the input of single trials explain a significant part of the observed responses. Our results show that modelling the precise internal representations of human participants helps predict when perceptual decisions go wrong. Furthermore, by modelling precisely the stimuli at the single-trial level, we were able to identify the underlying mechanism of perceptual decision making in more detail than standard models. PMID:26752272

  18. Sexual preference for child and aggressive stimuli: comparison of rapists and child molesters using auditory and visual stimuli.

    PubMed

    Miner, M H; West, M A; Day, D M

    1995-06-01

    154 Ss were tested using penile plethysmography as part of intake into a voluntary inpatient sex offender treatment program. The testing protocol included slide stimuli of nude males and females in four age categories ranging from age 1 to adult; audiotaped descriptions of sexual activity with children of both genders which included fondling, sexual contact with no resistance, coercive sexual contact, sexual assault, nonsexual assault, and consensual sexual contact with an adult; videotaped depictions of rape of an adult woman, nonsexual assault of an adult woman and consensual sexual involvement with an adult woman, and audiotaped descriptions that paralleled the videotapes. The results indicated that child molesters (male victim) show a decidedly more offense related arousal profile than either child molesters (female victim) or rapists, and that the profiles of child molesters (female victim) and rapists are remarkably similar, although statistically significantly different from each other. Rapists respond significantly more to rape and nonsexual assault than either of the two child molester groups, with child molesters with female victims responding more than those with male victims. In all three groups, the highest level of noncoercive adult responding was to women, with differences among offense groups present for visual stimuli, but not in response to auditory stimuli. Overall, the patterns of results are similar whether they are based on composites across stimulus modality or on the individual stimuli. PMID:7598675

  19. Validation of an automated punctate mechanical stimuli delivery system designed for fMRI studies in rodents.

    PubMed

    Governo, Ricardo Jose Moylan; Prior, Malcolm John William; Morris, Peter Gordon; Marsden, Charles Alexander; Chapman, Victoria

    2007-06-15

    Functional magnetic resonance imaging (fMRI) is increasingly being used for animal studies studying the transmission of nociceptive information. Application of noxious mechanical stimuli is widely used for animal and human assessment of pain processing. Any accessory hardware used in animal imaging studies must, however, be sufficiently small to fit in the magnet bore diameter and be non-magnetic. We have developed a system that can apply mechanical stimuli simultaneously with fMRI. This system consists of a standardized instrument to deliver mechanical stimuli (VonFrey monofilament) and a gas-pressured mechanical transducer. These components were integrated with a computer console that controlled the period of stimuli to match acquisition scans. Preliminary experiments demonstrated that the force-stimulus transducer did not influence MRI signal to noise ratio. Mechanical stimulation of the hindpaw significantly increased blood oxygen level dependent (BOLD) signal intensity in several midbrain regions involved in the processing of nociceptive information in the rat (p<0.001, uncorrected for multiple comparisons). This system can be applied to both animal and human imaging studies and has a wide range of applications for studies of nociceptive processing. PMID:17368787

  20. Standardization versus Standards.

    ERIC Educational Resources Information Center

    Meier, Deborah

    2002-01-01

    Examines differences between old state-designed norm-referenced tests and new tests aligned with the curriculum. Concludes that new state tests are very similar to old ones. Discusses impact of new high-stakes standardized tests on students and teachers. Argues the new wave of standardized testing is not the answer to improving student…

  1. Stimuli-responsive supramolecular polymers in aqueous solution.

    PubMed

    Ma, Xiang; Tian, He

    2014-07-15

    CONSPECTUS: Aiming to construct various novel supramolecular polymeric structures in aqueous solution beyond small supramolecular self-assembly molecules and develop functional supramolecular polymeric materials, research interest on functional supramolecular polymers has been prevailing in recent years. Supramolecular polymers are formed by bridging monomers or components together via highly directional noncovalent interactions such as hydrogen bonding, hydrophobic interaction, π-π interaction, metal-ligand coordination, electrostatic interaction, and so forth. They can be easily functionalized by employing diverse building components with specific functions besides the traditional polymeric properties, a number of which are responsive to such external stimuli as pH variance, photoirradiation, chemically or electrochemically redox with the controllable conformation or construction switching, polymerization building and rebuilding, and function adjustment reversibly owing to the reversibility of noncovalent interactions. Supramolecular polymers are "soft matters" and can be functionalized with specific properties such as morphology adjustment, controllable luminescence, shape memory, self-healing, and so forth. Supramolecular polymers constructed based on macrocycle recognition and interlocked structures represent one typical branch of the supramolecular polymer family. Cyclodextrin (CD), cucurbituril (CB), and hydrophilic calixarene derivatives are usually employed to construct hydrophilic supramolecular polymers in aqueous solution. Stimuli-responsive hydrophilic supramolecular polymers, constructed in aqueous solution particularly, can be promising candidates for mimicking biocompatible or vital functional materials. This Account mainly focuses on the recent stimuli-responsive supramolecular polymers based on the host-guest interaction in aqueous solution. We describe the hydrophilic supramolecular polymers constructed via hydrophobic effects, electrostatic

  2. Standards not that standard.

    PubMed

    Vilanova, Cristina; Tanner, Kristie; Dorado-Morales, Pedro; Villaescusa, Paula; Chugani, Divya; Frías, Alba; Segredo, Ernesto; Molero, Xavier; Fritschi, Marco; Morales, Lucas; Ramón, Daniel; Peña, Carlos; Peretó, Juli; Porcar, Manuel

    2015-01-01

    There is a general assent on the key role of standards in Synthetic Biology. In two consecutive letters to this journal, suggestions on the assembly methods for the Registry of standard biological parts have been described. We fully agree with those authors on the need of a more flexible building strategy and we highlight in the present work two major functional challenges standardization efforts have to deal with: the need of both universal and orthogonal behaviors. We provide experimental data that clearly indicate that such engineering requirements should not be taken for granted in Synthetic Biology. PMID:26435739

  3. Assessing Spatial and Temporal Properties of Perimetric Stimuli for Resistance to Clinical Variations in Retinal Illumination

    PubMed Central

    Swanson, William H.; Dul, Mitchell W.; Horner, Douglas G.; Liu, Tiffany; Tran, Irene

    2014-01-01

    Purpose. To develop perimetric stimuli for which sensitivities are more resistant to reduced retinal illumination than current clinical perimeters. Methods. Fifty-four people free of eye disease were dilated and tested monocularly. For each test, retinal illumination was attenuated with neutral density (ND) filters, and a standard adaptation model was fit to derive mean and SEM for the adaptation parameter (NDhalf). For different stimuli, t-tests on NDhalf were used to assess significance of differences in consistency with Weber's law. Three experiments used custom Gaussian-windowed contrast sensitivity perimetry (CSP). Experiment 1 used CSP-1, with a Gaussian temporal pulse, a spatial frequency of 0.375 cyc/deg (cpd), and SD of 1.5°. Experiment 1 also used the Humphrey Matrix perimeter, with the N-30 test using 0.25 cpd and 25 Hz flicker. Experiment 2 used a rectangular temporal pulse, SDs of 0.25° and 0.5°, and spatial frequencies of 0.0 and 1.0 cpd. Experiment 3 used CSP-2, with 5-Hz flicker, SDs from 0.5° to 1.8°, and spatial frequencies from 0.14 to 0.50 cpd. Results. In Experiment 1, CSP-1 was more consistent with Weber's law (NDhalf ± SEM = 1.86 ± 0.08 log unit) than N-30 (NDhalf = 1.03 ± 0.03 log unit; t > 9, P < 0.0001). All stimuli used in Experiments 2 and 3 had comparable consistency with Weber's law (NDhalf = 1.49–1.69 log unit; t < 2). Conclusions. Perimetric sensitivities were consistent with Weber's law when higher temporal frequencies were avoided. PMID:24370832

  4. Chords and harmonies in mixed optical and acoustical stimuli

    NASA Astrophysics Data System (ADS)

    Hahlweg, Cornelius; Dannenberg, Florian; Dörfler, Joachim; Weber, Bernhard; Weyer, Cornelia; Gercke-Hahn, Harald; Freimuth, Steffen; Heucke, Sören; Gutzmann, Holger Ludwig

    2014-09-01

    The paper is a follow up of the work presented in last year's Optics and Music session on the perception of coherence between low frequency power modulated light and periodical acoustic stimuli. The composition of chords and harmonies from power modulated light sources and their effect as stand-alone stimulus and in conjunction with the equivalent acoustic signal is discussed. Of special interest here is the modulation near perceptible flicker frequency. The substitution of acoustical chord components by their optical counterpart and vice versa is investigated. Further, concepts of a training application for trombone players and other instrumentalists are presented: since the mean slide of the trombone does not have fixed positions, the note must be found and two players might influence each other. The possibility of helping them to synchronize by optical stimuli derived from their playing is investigated. Beside possible applications in emotional reinforcing multimedia oriented entertainment and training support for musicians, again implications for occupational medicine are discussed.

  5. Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

    PubMed Central

    Torchilin, Vladimir P.

    2015-01-01

    The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the in vivo effectiveness of drugs is now well established. The development of multifunctional and stimulus-sensitive NDDSs is an active area of current research. Such NDDSs can have long circulation times, target the site of the disease and enhance the intracellular delivery of a drug. This type of NDDS can also respond to local stimuli that are characteristic of the pathological site by, for example, releasing an entrapped drug or shedding a protective coating, thus facilitating the interaction between drug-loaded nanocarriers and target cells or tissues. In addition, imaging contrast moieties can be attached to these carriers to track their real-time biodistribution and accumulation in target cells or tissues. Here, I highlight recent developments with multifunctional and stimuli-sensitive NDDSs and their therapeutic potential for diseases including cancer, cardiovascular diseases and infectious diseases. PMID:25287120

  6. Tagging multiple emotional stimuli: negative valence has little benefit.

    PubMed

    Watson, Derrick G; Blagrove, Elisabeth

    2012-06-01

    Six experiments examined the influence of emotional valence on the tagging and enumeration of multiple targets. Experiments 1, 5 and 6 found that there was no difference in the efficiency of tagging/enumerating multiple negative or positive stimuli. Experiment 2 showed that, when neutral-expression face distractors were present, enumerating negative targets was faster overall, but was only more efficient for small numbers of targets. Experiments 3 and 4 determined that this negative target advantage was most likely caused by increased attentional guidance to negatively-valenced stimuli and was not based on simple visual feature differences. The findings suggest that a multiple-target negative stimulus advantage will only occur under conditions of attentional competition, and for relatively small numbers of targets. The results are discussed in relation to theories of multiple- and single-item processing, threat-priority mechanisms, and the types of representations that support different attentional tasks. PMID:22201468

  7. Functional stimuli responsive hydrogel devices by self-folding

    NASA Astrophysics Data System (ADS)

    Yoon, ChangKyu; Xiao, Rui; Park, JaeHyun; Cha, Jaepyeong; Nguyen, Thao D.; Gracias, David H.

    2014-09-01

    We describe a photolithographic approach to create functional stimuli responsive, self-folding, microscale hydrogel devices using thin, gradient cross-linked hinges and thick, fully cross-linked panels. The hydrogels are composed of poly (N-isopropylacrylamide-co-acrylic acid) (pNIPAM-AAc) with reversible stimuli responsive properties just below physiological temperatures. We show that a variety of three-dimensional structures can be formed and reversibly actuated by temperature or pH. We experimentally characterized the swelling and mechanical properties of pNIPAM-AAc and developed a finite element model to rationalize self-folding and its variation with hinge thickness and swelling ratio. Finally, we highlight applications of this approach in the creation of functional devices such as self-folding polymeric micro-capsules, untethered micro-grippers and thermally steered micro-mirror systems.

  8. Preparation and Characterization of Stimuli-Responsive Magnetic Nanoparticles

    NASA Astrophysics Data System (ADS)

    Wang, Shixing; Zhou, Yang; Guan, Wen; Ding, Bingjun

    2008-08-01

    In this work, the main attention was focused on the synthesis of stimuli-responsive magnetic nanoparticles (SR-MNPs) and the influence of glutathione concentration on its cleavage efficiency. Magnetic nanoparticles (MNPs) were first modified with activated pyridyldithio. Then, MNPs modified with activated pyridyldithio (MNPs-PDT) were conjugated with 2, 4-diamino-6-mercaptopyrimidine (DMP) to form SR-MNPs via stimuli-responsive disulfide linkage. Fourier transform infrared spectra (FTIR), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) were used to characterize MNPs-PDT. The disulfide linkage can be cleaved by reduced glutathione (GHS). The concentration of glutathione plays an important role in controlling the cleaved efficiency. The optimum concentration of GHS to release DMP is in the millimolar range. These results had provided an important insight into the design of new MNPs for biomedicine applications, such as drug delivery and bio-separation.

  9. Stimuli-responsive hydrogels in drug delivery and tissue engineering.

    PubMed

    Sood, Nikhil; Bhardwaj, Ankur; Mehta, Shuchi; Mehta, Abhinav

    2016-01-01

    Hydrogels are the three-dimensional network structures obtained from a class of synthetic or natural polymers which can absorb and retain a significant amount of water. Hydrogels are one of the most studied classes of polymer-based controlled drug release. These have attracted considerable attention in biochemical and biomedical fields because of their characteristics, such as swelling in aqueous medium, biocompatibility, pH and temperature sensitivity or sensitivity towards other stimuli, which can be utilized for their controlled zero-order release. The hydrogels are expected to explore new generation of self-regulated delivery system having a wide array of desirable properties. This review highlights the exciting opportunities and challenges in the area of hydrogels. Here, we review different literatures on stimuli-sensitive hydrogels, such as role of temperature, electric potential, pH and ionic strength to control the release of drug from hydrogels. PMID:25045782

  10. Effects of practice on identification of multidimensional stimuli.

    PubMed

    Shieh, K K; Lai, C J

    1996-10-01

    This study investigated the effects of practice on the identification of multidimensional stimuli. Subjects were instructed to perform a two dimensional identification task. The stimuli could be identified either physically or connotatively. There were two orders of reporting the two dimensions of a stimulus. Analysis showed that method of identification and order of report significantly affected speed of identification. Physical identification was faster than identification of meaning. An appropriate order of report shortened response times, and increased practice reduced response times. Practice in multidimensional identification seemed to follow the same laws and trends of unidimensional performance. The effects of practice on multimensional identification could be represented by straight lines if response times were plotted against the logarithm of the number of trials as noted in unidimensional performance. Further, practice attenuated initial differences in response times between physical identification and identification of meaning. PMID:8902016

  11. Stimuli-responsive nanoparticles from ionic cellulose derivatives

    NASA Astrophysics Data System (ADS)

    Wang, Yonggui; Heinze, Thomas; Zhang, Kai

    2015-12-01

    Stimuli-responsive nanoparticles (NPs) based on sustainable polymeric feedstock still need more exploration in comparison with NPs based on synthetic polymers. In this report, stimuli-responsive NPs from novel ionic cellulose derivatives were prepared via a facile nanoprecipitation. Cellulose 10-undecenoyl ester (CUE) with a degree of substitution (DS) of 3 was synthesized by esterification of cellulose with 10-undecenoyl chloride. Then, CUE was modified by photo-induced thiol-ene reactions, in order to obtain organo-soluble ionic cellulose derivatives with DSs of ~3, namely cellulose 11-((3-carboxyl)ethylthio)undecanoate (CUE-MPA), cellulose 11-((2-aminoethyl)thio)undecanoate (CUE-CA), cellulose 11-(2-(2-(diethylamino)ethyl)thio)undecanoate (CUE-DEAET) and cellulose 11-(2-(2-(dimethylamino)ethyl)thio)undecanoate (CUE-DMAET). CUE-MPA could be transformed into NPs with average diameters in the range of 80-330 nm, but these NPs did not show particular stimuli-responsive properties. Moreover, the dropping technique resulted in smaller NPs than a dialysis technique. Stable NPs with average diameters in the range of 90-180 nm showing pH-responsive and switchable sizes were obtained from CUE-DEAET and CUE-DMAET possessing tertiary amines using nanoprecipitation. Thus, altering the terminal functional groups will be a new approach to prepare stimuli-responsive cellulose-derived polymeric NPs.Stimuli-responsive nanoparticles (NPs) based on sustainable polymeric feedstock still need more exploration in comparison with NPs based on synthetic polymers. In this report, stimuli-responsive NPs from novel ionic cellulose derivatives were prepared via a facile nanoprecipitation. Cellulose 10-undecenoyl ester (CUE) with a degree of substitution (DS) of 3 was synthesized by esterification of cellulose with 10-undecenoyl chloride. Then, CUE was modified by photo-induced thiol-ene reactions, in order to obtain organo-soluble ionic cellulose derivatives with DSs of ~3, namely cellulose

  12. Imagery vividness, hypnotic susceptibility, and the perception of fragmented stimuli.

    PubMed

    Wallace, B

    1990-02-01

    Two experiments were conducted to determine the role of hypnotic susceptibility level (high or low) and imaging ability (vivid or poor) in the performance of gestalt closure tasks. In Experiment 1, subjects were required to identify fragmented stimuli in the Closure Speed Test and in the Street Test. In Experiment 2, subjects reported on fragmented stimuli that were projected to the right eye and subsequently produced an afterimage. Individuals were asked to identify the composite if possible and to report on the duration of the afterimage. In both experiments, hypnotic susceptibility level and imaging ability affected reports of gestalt closure. The greatest number of correct closures was reported by those who were both high in hypnotic susceptibility and vivid in imaging ability. In addition, in the second experiment, this group also reported the longest enduring afterimage. These results are discussed in terms of the processes required to perform in a gestalt closure task. PMID:2319447

  13. Classical conditioning through auditory stimuli in Drosophila: methods and models

    PubMed Central

    Menda, Gil; Bar, Haim Y.; Arthur, Ben J.; Rivlin, Patricia K.; Wyttenbach, Robert A.; Strawderman, Robert L.; Hoy, Ronald R.

    2011-01-01

    SUMMARY The role of sound in Drosophila melanogaster courtship, along with its perception via the antennae, is well established, as is the ability of this fly to learn in classical conditioning protocols. Here, we demonstrate that a neutral acoustic stimulus paired with a sucrose reward can be used to condition the proboscis-extension reflex, part of normal feeding behavior. This appetitive conditioning produces results comparable to those obtained with chemical stimuli in aversive conditioning protocols. We applied a logistic model with general estimating equations to predict the dynamics of learning, which successfully predicts the outcome of training and provides a quantitative estimate of the rate of learning. Use of acoustic stimuli with appetitive conditioning provides both an alternative to models most commonly used in studies of learning and memory in Drosophila and a means of testing hearing in both sexes, independently of courtship responsiveness. PMID:21832129

  14. Effects of rectilinear acceleration, optokinetic and caloric stimuli in space

    NASA Technical Reports Server (NTRS)

    Vonbaumgarten, R.

    1981-01-01

    The set of experiments comprising the Spacelab 1ES201 package designed to investigate the human vestibular system and equilibratory function in weightlessness are described. The specific objectives of the experiments include: (1) the determination of the threshold of perception of linear oscillatory motion; (2) measurement of physiological and subjective responses to supra threshold, linear and angular motion stimuli; (3) study of the postural adjustments, eye movements, and illusions of attitude and motion evoked by optokinetic stimuli, (i.e., moving visual patterns) in order to assess visual/vestibular interactions; (4) examination of the effect of thermal stimulations of the vestibular apparatus to determine if the eye movements elicited by the 'caloric test' are used by a density gradient in the semicircular canal; and (5) investigation of the pathogenesis of space motion sickness by recording signs and symptoms during the course of vestibular stimulation and, specifically, when the test subject is exposed to sustained, linear oscillatory motion.

  15. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: RSD measurement from the LOS-dependent power spectrum of DR12 BOSS galaxies

    NASA Astrophysics Data System (ADS)

    Gil-Marín, Héctor; Percival, Will J.; Brownstein, Joel R.; Chuang, Chia-Hsun; Grieb, Jan Niklas; Ho, Shirley; Kitaura, Francisco-Shu; Maraston, Claudia; Prada, Francisco; Rodríguez-Torres, Sergio; Ross, Ashley J.; Samushia, Lado; Schlegel, David J.; Thomas, Daniel; Tinker, Jeremy L.; Zhao, Gong-Bo

    2016-08-01

    We measure and analyse the clustering of the Baryon Oscillation Spectroscopic Survey (BOSS) relative to the line-of-sight (LOS), for LOWZ and CMASS galaxy samples drawn from the final Data Release 12 (DR12). The LOWZ sample contains 361\\,762 galaxies with an effective redshift of $z_{\\rm lowz}=0.32$, and the CMASS sample 777\\,202 galaxies with an effective redshift of $z_{\\rm cmass}=0.57$. From the power spectrum monopole and quadrupole moments around the LOS, we measure the growth of structure parameter $f$ times the amplitude of dark matter density fluctuations $\\sigma_8$ by modeling the Redshift-Space Distortion signal. When the geometrical Alcock-Paczynski effect is also constrained from the same data, we find joint constraints on $f\\sigma_8$, the product of the Hubble constant and the comoving sound horizon at the baryon drag epoch $H(z)r_s(z_d)$, and the angular distance parameter divided by the sound horizon $D_A(z)/r_s(z_d)$. We find $f(z_{\\rm lowz})\\sigma_8(z_{\\rm lowz})=0.394\\pm0.062$, $D_A(z_{\\rm lowz})/r_s(z_d)=6.35\\pm0.19$, $H(z_{\\rm lowz})r_s(z_d)=(11.41\\pm 0.56)\\,{10^3\\rm km}s^{-1}$ for the LOWZ sample, and $f(z_{\\rm cmass})\\sigma_8(z_{\\rm cmass})=0.444\\pm0.038$, $D_A(z_{\\rm cmass})/r_s(z_d)=9.42\\pm0.15$, $H(z_{\\rm cmass})r_s(z_d)=(13.92 \\pm 0.44)\\, {10^3\\rm km}s^{-1}$ for the CMASS sample. We find general agreement with previous BOSS DR11 measurements. Assuming the Hubble parameter and angular distance parameter are fixed at fiducial $\\Lambda$CDM values, we find $f(z_{\\rm lowz})\\sigma_8(z_{\\rm lowz})=0.485\\pm0.044$ and $f(z_{\\rm cmass})\\sigma_8(z_{\\rm cmass})=0.436\\pm0.022$ for the LOWZ and CMASS samples, respectively.

  16. System of Personal Identification by Using Tactile Stimuli

    NASA Astrophysics Data System (ADS)

    Park, Young-Il; Uchida, Masafumi

    In present, personal identfication system have been used to input identification-numbers and passwords by keyboards and touch panels. When a user enters their identification-numbers and passwords an observer could easily see the user's secret details. In this report, new personal identification, which system constitutes tactile sense information using tactile stimuli and based on the cardinal trait of the tactile sense, is proposed.

  17. Interpersonal touch suppresses visual processing of aversive stimuli

    PubMed Central

    Kawamichi, Hiroaki; Kitada, Ryo; Yoshihara, Kazufumi; Takahashi, Haruka K.; Sadato, Norihiro

    2015-01-01

    Social contact is essential for survival in human society. A previous study demonstrated that interpersonal contact alleviates pain-related distress by suppressing the activity of its underlying neural network. One explanation for this is that attention is shifted from the cause of distress to interpersonal contact. To test this hypothesis, we conducted a functional MRI (fMRI) study wherein eight pairs of close female friends rated the aversiveness of aversive and non-aversive visual stimuli under two conditions: joining hands either with a rubber model (rubber-hand condition) or with a close friend (human-hand condition). Subsequently, participants rated the overall comfortableness of each condition. The rating result after fMRI indicated that participants experienced greater comfortableness during the human-hand compared to the rubber-hand condition, whereas aversiveness ratings during fMRI were comparable across conditions. The fMRI results showed that the two conditions commonly produced aversive-related activation in both sides of the visual cortex (including V1, V2, and V5). An interaction between aversiveness and hand type showed rubber-hand-specific activation for (aversive > non-aversive) in other visual areas (including V1, V2, V3, and V4v). The effect of interpersonal contact on the processing of aversive stimuli was negatively correlated with the increment of attentional focus to aversiveness measured by a pain-catastrophizing scale. These results suggest that interpersonal touch suppresses the processing of aversive visual stimuli in the occipital cortex. This effect covaried with aversiveness-insensitivity, such that aversive-insensitive individuals might require a lesser degree of attentional capture to aversive-stimulus processing. As joining hands did not influence the subjective ratings of aversiveness, interpersonal touch may operate by redirecting excessive attention away from aversive characteristics of the stimuli. PMID:25904856

  18. Brain response to visual sexual stimuli in homosexual pedophiles

    PubMed Central

    Schiffer, Boris; Krueger, Tillmann; Paul, Thomas; de Greiff, Armin; Forsting, Michael; Leygraf, Norbert; Schedlowski, Manfred; Gizewski, Elke

    2008-01-01

    Objective The neurobiological mechanisms of deviant sexual preferences such as pedophilia are largely unknown. The objective of this study was to analyze whether brain activation patterns of homosexual pedophiles differed from those of a nonpedophile homosexual control group during visual sexual stimulation. Method A consecutive sample of 11 pedophile forensic inpatients exclusively attracted to boys and 12 age-matched homosexual control participants from a comparable socioeconomic stratum underwent functional magnetic resonance imaging during a visual sexual stimulation procedure that used sexually stimulating and emotionally neutral photographs. Sexual arousal was assessed according to a subjective rating scale. Results In contrast to sexually neutral pictures, in both groups sexually arousing pictures having both homosexual and pedophile content activated brain areas known to be involved in processing visual stimuli containing emotional content, including the occipitotemporal and prefrontal cortices. However, during presentation of the respective sexual stimuli, the thalamus, globus pallidus and striatum, which correspond to the key areas of the brain involved in sexual arousal and behaviour, showed significant activation in pedophiles, but not in control subjects. Conclusions Central processing of visual sexual stimuli in homosexual pedophiles seems to be comparable to that in nonpedophile control subjects. However, compared with homosexual control subjects, activation patterns in pedophiles refer more strongly to subcortical regions, which have previously been discussed in the context of processing reward signals and also play an important role in addictive and stimulus-controlled behaviour. Thus future studies should further elucidate the specificity of these brain regions for the processing of sexual stimuli in pedophilia and should address the generally weaker activation pattern in homosexual men. PMID:18197269

  19. Temporal sensitivity. [time dependent human perception of visual stimuli

    NASA Technical Reports Server (NTRS)

    Watson, Andrew B.

    1986-01-01

    Human visual temporal sensitivity is examined. The stimuli used to measure temporal sensitivity are described and the linear systems theory is reviewed in terms of temporal sensitivity. A working model which represents temporal sensitivity is proposed. The visibility of a number of temporal wave forms, sinusoids, rectangular pulses, and pulse pairs, is analyzed. The relation between spatial and temporal effects is studied. Temporal variations induced by image motion and the effects of light adaptation on temporal sensitivity are considered.

  20. Equivalence-Equivalence: Matching Stimuli with Same Discriminative Functions

    ERIC Educational Resources Information Center

    Carpentier, Franck; Smeets, Paul M.; Barnes-Holmes, Dermot

    2004-01-01

    Previous studies have shown that after being trained on A-B and A-C match-to-sample tasks, adults match not only same-class B and C stimuli (equivalence) but also BC compounds with same-class elements and with different-class elements (BC-BC). The assumption was that the BC-BC performances are based on matching equivalence and nonequivalence…

  1. Fertility of beef cattle females with mating stimuli around insemination.

    PubMed

    Rodriguez, R O; Rivera, M J

    1999-01-29

    An experiment was conducted to test the hypothesis that sterile mounts around insemination improves pregnancy rate to artificial insemination (AI) and to define the effects of age, season, time to complete AI and time of day of insemination. A total of 178 Simbrah females were randomly assigned by calving date and body condition to one of three treatments during two consecutive years: (1) mating stimuli with a sterile bull at the time the cows were detected in estrus; (2) mating stimuli immediately after completing AI; (3) without mating stimuli. All cows and heifers were maintained under the same conditions of handling and feeding within the two breeding seasons (winter 1995 and summer 1996). Vasectomized bulls were used for the sterile mounts. Cows and heifers that were given a sterile mount at the time of detection of estrus, had an increased pregnancy rate (60.0%) compared with females given a sterile mount after completing AI (25.4%) or females without the sterile mount (35.6%) (P < 0.01). Age, season, time to complete AI and time of day of AI were all non-significant (P > 0.05). Therefore, there is a biostimulatory effect of mating at the time beef cattle females are detected in estrus, on pregnancy rates to AI. PMID:10090564

  2. Hemispheric specialization in dogs for processing different acoustic stimuli.

    PubMed

    Siniscalchi, Marcello; Quaranta, Angelo; Rogers, Lesley J

    2008-01-01

    Considerable experimental evidence shows that functional cerebral asymmetries are widespread in animals. Activity of the right cerebral hemisphere has been associated with responses to novel stimuli and the expression of intense emotions, such as aggression, escape behaviour and fear. The left hemisphere uses learned patterns and responds to familiar stimuli. Although such lateralization has been studied mainly for visual responses, there is evidence in primates that auditory perception is lateralized and that vocal communication depends on differential processing by the hemispheres. The aim of the present work was to investigate whether dogs use different hemispheres to process different acoustic stimuli by presenting them with playbacks of a thunderstorm and their species-typical vocalizations. The results revealed that dogs usually process their species-typical vocalizations using the left hemisphere and the thunderstorm sounds using the right hemisphere. Nevertheless, conspecific vocalizations are not always processed by the left hemisphere, since the right hemisphere is used for processing vocalizations when they elicit intense emotion, including fear. These findings suggest that the specialisation of the left hemisphere for intraspecific communication is more ancient that previously thought, and so is specialisation of the right hemisphere for intense emotions. PMID:18843371

  3. Stimuli-responsive photoacoustic nanoswitch for in vivo sensing applications.

    PubMed

    Ng, Kenneth K; Shakiba, Mojdeh; Huynh, Elizabeth; Weersink, Robert A; Roxin, Áron; Wilson, Brian C; Zheng, Gang

    2014-08-26

    Photoacoustic imaging provides high-resolution images at depths beyond the optical diffusion limit. To broaden its utility, there is need for molecular sensors capable of detecting environmental stimuli through alterations in photoacoustic signal. Photosynthetic organisms have evolved ingenious strategies to optimize light absorption through nanoscale ordered dye aggregation. Here, we use this concept to synthesize a stimuli-responsive nanoswitch with a large optical absorbance and sensing capabilities. Ordered dye aggregation between light-harvesting porphyrins was achieved through intercalation within thermoresponsive nanovesicles. This causes an absorbance red-shift of 74 nm and a 2.7-fold increase in absorptivity of the Qy-band, with concomitant changes in its photoacoustic spectrum. This spectral feature can be reversibly switched by exceeding a temperature threshold. Using this thermochromic property, we noninvasively determined a localized temperature change in vivo, relevant for monitoring thermal therapies of solid tumors. Similar strategies may be applied alongside photoacoustic imaging, to detect other stimuli such as pH and enzymatic activity. PMID:25046406

  4. Oxytocin facilitates protective responses to aversive social stimuli in males

    PubMed Central

    Striepens, Nadine; Scheele, Dirk; Kendrick, Keith M.; Becker, Benjamin; Schäfer, Lea; Schwalba, Knut; Reul, Jürgen; Maier, Wolfgang; Hurlemann, René

    2012-01-01

    The neuropeptide oxytocin (OXT) can enhance the impact of positive social cues but may reduce that of negative ones by inhibiting amygdala activation, although it is unclear whether the latter causes blunted emotional and mnemonic responses. In two independent double-blind placebo-controlled experiments, each involving over 70 healthy male subjects, we investigated whether OXT affects modulation of startle reactivity by aversive social stimuli as well as subsequent memory for them. Intranasal OXT potentiated acoustic startle responses to negative stimuli, without affecting behavioral valence or arousal judgments, and biased subsequent memory toward negative rather than neutral items. A functional MRI analysis of this mnemonic effect revealed that, whereas OXT inhibited amygdala responses to negative stimuli, it facilitated left insula responses for subsequently remembered items and increased functional coupling between the left amygdala, left anterior insula, and left inferior frontal gyrus. Our results therefore show that OXT can potentiate the protective and mnemonic impact of aversive social information despite reducing amygdala activity, and suggest that the insula may play a role in emotional modulation of memory. PMID:23074247

  5. Development of infant contrast sensitivity to chromatic stimuli.

    PubMed

    Morrone, M C; Burr, D C; Fiorentini, A

    1993-12-01

    We have monitored the development of contrast sensitivity to equiluminant red-green chromatic patterns by monitoring visual evoked potentials (VEPs) in 13 infants. The results confirm our previous report [Morrone, Burr and Fiorentini, Proceedings of the Royal Society B, 242 (1990a)] that, before 7-8 weeks of age, there was no response to purely chromatic stimuli, while at the same age luminance stimuli of 20% contrast produced reliable responses. At all ages (even before the onset of a chromatic response) the colour mixture to yield equiluminance was similar to that of adults, suggesting that the relative proportion and efficacy of medium- and long-wave cones is similar for infants as for adults. For both luminance and chromatic stimuli, amplitude increased roughly linearly with log-contrast, so sensitivity thresholds could be predicted by linear extrapolation to the abscissa. Detailed contrast sensitivity curves were measured for four infants at various ages. The results show that luminance and chromatic contrast sensitivity develop independently at different rates, probably reflecting differential development of postreceptoral neural mechanisms. PMID:8249333

  6. Attention modulates the dorsal striatum response to love stimuli.

    PubMed

    Langeslag, Sandra J E; van der Veen, Frederik M; Röder, Christian H

    2014-02-01

    In previous functional magnetic resonance imaging (fMRI) studies concerning romantic love, several brain regions including the caudate and putamen have consistently been found to be more responsive to beloved-related than control stimuli. In those studies, infatuated individuals were typically instructed to passively view the stimuli or to think of the viewed person. In the current study, we examined how the instruction to attend to, or ignore the beloved modulates the response of these brain areas. Infatuated individuals performed an oddball task in which pictures of their beloved and friend served as targets and distractors. The dorsal striatum showed greater activation for the beloved than friend, but only when they were targets. The dorsal striatum actually tended to show less activation for the beloved than the friend when they were distractors. The longer the love and relationship duration, the smaller the response of the dorsal striatum to beloved-distractor stimuli was. We interpret our findings in terms of reinforcement learning. By virtue of using a cognitive task with a full factorial design, we show that the dorsal striatum is not activated by beloved-related information per se, but only by beloved-related information that is attended. PMID:23097247

  7. Non-nutritive sweeteners are not super-normal stimuli

    PubMed Central

    Antenucci, Rachel G.; Hayes, John E.

    2014-01-01

    Background It is often claimed that non-nutritive sweeteners (NNS) are ‘sweeter than sugar’, with the implicit implication high potency sweeteners are super-normal stimuli that encourage exaggerated responses. This study aimed to investigate the perceived sweetness intensity of a variety of nutritive (Sucrose, Maple Syrup, and Agave Nectar) and NNS (Acesulfame-K (AceK), Rebaudioside A (RebA), Aspartame, and Sucralose) in a large cohort of untrained participants using contemporary psychophysical methods. Methods Participants (n=401 total) rated the intensity of sweet, bitter, and metallic sensations for nutritive and NNS in water using the general labeled magnitude scale (gLMS). Results Sigmoidal Dose-Response functions were observed for all stimuli except AceK. That is, sucrose follows a sigmoidal function if the data are not artifactually linearized via prior training. More critically, there is no evidence that NNS have a maximal sweetness (intensity) greater than sucrose; indeed, the maximal sweetness for AceK, RebA and Sucralose were significantly lower than for concentrated sucrose. For these sweeteners, mixture suppression due to endogenous dose-dependent bitter or metallic sensations appears to limit maximal perceived sweetness. Conclusions In terms of perceived sweetness, non-nutritive sweeteners cannot be considered super-normal stimuli. These data do not support the view that non-nutritive sweeteners hijack or over-stimulate sweet receptors to product elevated sweet sensations. PMID:24942868

  8. Bile salts are effective taste stimuli in channel catfish.

    PubMed

    Rolen, S H; Caprio, J

    2008-09-01

    Bile salts are known olfactory stimuli for teleosts, but only a single report has indicated that the taste system of a fish was sensitive to this class of stimuli. Here, gustatory responses of the channel catfish, Ictalurus punctatus, to four bile salts that included taurine-, glycine- and non-conjugated compounds along with three stimulatory amino acids as a comparison were investigated using extracellular electrophysiological techniques. Integrated multiunit responses were obtained from the branch of the facial nerve innervating taste buds on the maxillary barbel. Bile salts were shown to be highly effective facial taste stimuli, with estimated electrophysiological thresholds for three of the four tested bile salts of approximately 10(-11) mol l(-1) to 10(-10) mol l(-1), slightly lower by 1-2 log units than those to amino acids in the same species. Although the sensitivity of the facial taste system of the channel catfish to bile salts is high, the relative magnitude of the response to suprathreshold concentrations of bile salts was significantly less than that to amino acids. Multiunit cross-adaptation experiments indicate that bile salts and amino acids bind to relatively independent receptor sites; however, nerve-twig data and single-fiber recordings suggest that both independent and shared neural pathways exist for the transmission of bile salt and amino acid information to the primary gustatory nucleus of the medulla. PMID:18723536

  9. A dual-stimuli-responsive fluorescent switch ultrathin film.

    PubMed

    Li, Zhixiong; Liang, Ruizheng; Liu, Wendi; Yan, Dongpeng; Wei, Min

    2015-10-28

    Stimuli-responsive fluorescent switches have shown broad applications in optical devices, biological materials and intelligent responses. Herein, we describe the design and fabrication of a dual-stimuli-responsive fluorescent switch ultrathin film (UTF) via a three-step layer-by-layer (LBL) technique: (i) encapsulation of spiropyran (SP) within an amphiphilic block copolymer (PTBEM) to give the (SP@PTBEM) micelle; (ii) the mixture of riboflavin (Rf) and poly(styrene 4-sulfonate) (PSS) to enhance the adhesion ability of small molecules; (iii) assembly of negatively charged SP@PTBEM and Rf-PSS with cationic layered double hydroxide (LDH) nanoplatelets to obtain the (Rf-PSS/LDH/SP@PTBEM)n UTFs (n: bilayer number). The assembly process of the UTFs and their luminescence properties, as monitored by fluorescence spectroscopy and scanning electron microscopy (SEM), present a uniform and ordered layered structure with stepwise growth. The resulting Rf-PSS/LDH/SP@PTBEM UTF serves as a three-state switchable multicolor (green, yellow, and red) luminescent system based on stimulation from UV/Vis light and pH, with an acceptable reversibility. Therefore, this work provides a facile way to fabricate stimuli-responsive solid-state film switches with tunable-color luminescence, which have potential applications in the areas of displays, sensors, and rewritable optical memory and fluorescent logic devices. PMID:26400734

  10. Goldfish and oscars have comparable responsiveness to dipole stimuli

    NASA Astrophysics Data System (ADS)

    Nauroth, Ines Eva; Mogdans, Joachim

    2009-12-01

    The relative roles of the fish lateral line and inner ear for the perception of hydrodynamic stimuli are poorly investigated. Here, we studied responsiveness to a 100 Hz vibrating sphere (dipole stimulus) of goldfish and oscars, two species that differ in peripheral lateral line morphology, inner ear morphology, mechanical linkage between inner ear and swim bladder, and inner ear sensitivity. We measured unconditioned dipole-evoked changes in breathing activity in still water and in the presence of a 5-cm s-1 background flow. In still water, individuals from both species responded to sound pressure levels (SPLs) between 92 and 109 dB SPL re 1 μPaRMS. Responsiveness was not affected by background flow or by temporary inactivation of the lateral line. The data suggest that fish with different lateral line and inner ear morphologies have similar sensitivities to vibrating sphere stimuli and can detect and respond to dipole sources equally well in still water and in moderate background flows. Moreover, behavioral responses were not dependent on a functional lateral line, suggesting that in this type of experiment, the inner ear is the dominant sense organ for the perception of hydrodynamic stimuli.

  11. Expectations accelerate entry of visual stimuli into awareness.

    PubMed

    Pinto, Yair; van Gaal, Simon; de Lange, Floris P; Lamme, Victor A F; Seth, Anil K

    2015-01-01

    How do expectations influence transitions between unconscious and conscious perceptual processing? According to the influential predictive processing framework, perceptual content is determined by predictive models of the causes of sensory signals. On one interpretation, conscious contents arise when predictive models are verified by matching sensory input (minimizing prediction error). On another, conscious contents arise when surprising events falsify current perceptual predictions. Finally, the cognitive impenetrability account posits that conscious perception is not affected by such higher level factors. To discriminate these positions, we combined predictive cueing with continuous flash suppression (CFS) in which the relative contrast of a target image gradually increases over time. In four experiments we established that expected stimuli enter consciousness faster than neutral or unexpected stimuli. These effects are difficult to account for in terms of response priming, pre-existing stimulus associations, or the attentional mechanisms that cause asynchronous temporal order judgments (of simultaneously presented stimuli). Our results further suggest that top-down expectations play a larger role when bottom-up input is ambiguous, in line with predictive processing accounts of perception. Taken together, our findings support the hypothesis that conscious access depends on verification of perceptual predictions. PMID:26114676

  12. The Commonality of Loss Aversion across Procedures and Stimuli

    PubMed Central

    Kim, Byoung W.; Gilman, Jodi M.; Kuster, John K.; Blood, Anne J.; Kuhnen, Camelia M.

    2015-01-01

    Individuals tend to give losses approximately 2-fold the weight that they give gains. Such approximations of loss aversion (LA) are almost always measured in the stimulus domain of money, rather than objects or pictures. Recent work on preference-based decision-making with a schedule-less keypress task (relative preference theory, RPT) has provided a mathematical formulation for LA similar to that in prospect theory (PT), but makes no parametric assumptions in the computation of LA, uses a variable tied to communication theory (i.e., the Shannon entropy or information), and works readily with non-monetary stimuli. We evaluated if these distinct frameworks described similar LA in healthy subjects, and found that LA during the anticipation phase of the PT-based task correlated significantly with LA related to the RPT-based task. Given the ease with which non-monetary stimuli can be used on the Internet, or in animal studies, these findings open an extensive range of applications for the study of loss aversion. Furthermore, the emergence of methodology that can be used to measure preference for both social stimuli and money brings a common framework to the evaluation of preference in both social psychology and behavioral economics. PMID:26394306

  13. Endogenous Sequential Cortical Activity Evoked by Visual Stimuli

    PubMed Central

    Miller, Jae-eun Kang; Hamm, Jordan P.; Jackson, Jesse; Yuste, Rafael

    2015-01-01

    Although the functional properties of individual neurons in primary visual cortex have been studied intensely, little is known about how neuronal groups could encode changing visual stimuli using temporal activity patterns. To explore this, we used in vivo two-photon calcium imaging to record the activity of neuronal populations in primary visual cortex of awake mice in the presence and absence of visual stimulation. Multidimensional analysis of the network activity allowed us to identify neuronal ensembles defined as groups of cells firing in synchrony. These synchronous groups of neurons were themselves activated in sequential temporal patterns, which repeated at much higher proportions than chance and were triggered by specific visual stimuli such as natural visual scenes. Interestingly, sequential patterns were also present in recordings of spontaneous activity without any sensory stimulation and were accompanied by precise firing sequences at the single-cell level. Moreover, intrinsic dynamics could be used to predict the occurrence of future neuronal ensembles. Our data demonstrate that visual stimuli recruit similar sequential patterns to the ones observed spontaneously, consistent with the hypothesis that already existing Hebbian cell assemblies firing in predefined temporal sequences could be the microcircuit substrate that encodes visual percepts changing in time. PMID:26063915

  14. Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat.

    PubMed

    Sammons, Joshua D; Weiss, Michael S; Victor, Jonathan D; Di Lorenzo, Patricia M

    2016-07-01

    Several studies have shown that taste-responsive cells in the brainstem taste nuclei of rodents respond to sensory qualities other than gustation. Such data suggest that cells in the classical gustatory brainstem may be better tuned to respond to stimuli that engage multiple sensory modalities than to stimuli that are purely gustatory. Here, we test this idea by recording the electrophysiological responses to complex, naturalistic stimuli in single neurons in the parabrachial pons (PbN, the second neural relay in the central gustatory pathway) in awake, freely licking rats. Following electrode implantation and recovery, we presented both prototypical and naturalistic taste stimuli and recorded the responses in the PbN. Prototypical taste stimuli (NaCl, sucrose, citric acid, and caffeine) and naturalistic stimuli (clam juice, grape juice, lemon juice, and coffee) were matched for taste quality and intensity (concentration). Umami (monosodium glutamate + inosine monophosphate) and fat (diluted heavy cream) were also tested. PbN neurons responded to naturalistic stimuli as much or more than to prototypical taste stimuli. Furthermore, they convey more information about naturalistic stimuli than about prototypical ones. Moreover, multidimensional scaling analyses showed that across unit responses to naturalistic stimuli were more widely separated than responses to prototypical taste stimuli. Interestingly, cream evoked a robust and widespread response in PbN cells. Collectively, these data suggest that natural foods are more potent stimulators of PbN cells than purely gustatory stimuli. Probing PbN cells with pure taste stimuli may underestimate the response repertoire of these cells. PMID:27121585

  15. Development of degradable renewable polymers and stimuli-responsive nanocomposites

    NASA Astrophysics Data System (ADS)

    Eyiler, Ersan

    The overall goal of this research was to explore new living radical polymerization methods and the blending of renewable polymers. Towards this latter goal, polylactic acid (PLA) was blended with a new renewable polymer, poly(trimethylene-malonate) (PTM), with the aim of improving mechanical properties, imparting faster degradation, and examining the relationship between degradation and mechanical properties. Blend films of PLA and PTM with various ratios (5, 10, and 20 wt %) were cast from chloroform. Partially miscible blends exhibited Young's modulus and elongation-to-break values that significantly extend PLA's usefulness. Atomic force microscopy (AFM) data showed that incorporation of 10 wt% PTM into PLA matrix exhibited a Young's modulus of 4.61 GPa, which is significantly higher than that of neat PLA (1.69 GPa). The second part of the bioplastics study involved a one-week hydrolytic degradation study of PTM and another new bioplastic, poly(trimethylene itaconate) (PTI) using DI water (pH 5.4) at room temperature, and the effects of degradation on crystallinity and mechanical properties of these films were examined by differential scanning calorimetry (DSC) and AFM. PTI showed an increase in crystallinity with degradation, which was attributed to predominately degradation of free amorphous regions. Depending on the crystallinity, the elastic modulus increased at first, and decreased slightly. Both bulk and surface-tethered stimuli-responsive polymers were studied on amine functionalized magnetite (Fe3O4) nanoparticles. Stimuli-responsive polymers studied, including poly(N-isopropylacrylamide) (PNIPAM), poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA), and poly(itaconic acid) (PIA), were grafted via surface-initiated aqueous atom transfer radical polymerization (SI-ATRP). Both Fourier transform infrared spectroscopy (FTIR) and x-ray photoelectron spectroscopy (XPS) spectroscopies showed the progression of the grafting. The change in particle size as a

  16. SWITCHING NEURONAL STATE: OPTIMAL STIMULI REVEALED USING A STOCHASTICALLYSEEDED GRADIENT ALGORITHM

    PubMed Central

    Chang, Joshua; Paydarfar, David

    2014-01-01

    Inducing a switch in neuronal state using energy optimal stimuli is relevant to a variety of problems in neuroscience. Analytical techniques from optimal control theory can identify such stimuli; however, solutions to the optimization problem using indirect variational approaches can be elusive in models that describe neuronal behavior. Here we develop and apply a direct gradient-based optimization algorithm to find stimulus waveforms that elicit a change in neuronal state while minimizing energy usage. We analyze standard models of neuronal behavior, the Hodgkin-Huxley and FitzHugh-Nagumo models, to show that the gradient-based algorithm: 1) enables automated exploration of a wide solution space, using stochastically generated initial waveforms that converge to multiple locally optimal solutions; and 2) finds optimal stimulus waveforms that achieve a physiological outcome condition, without a priori knowledge of the optimal terminal condition of all state variables. Analysis of biological systems using stochastically-seeded gradient methods can reveal salient dynamical mechanisms underlying the optimal control of system behavior. The gradient algorithm may also have practical applications in future work, for example, finding energy optimal waveforms for therapeutic neural stimulation that minimizes power usage and diminishes off-target effects and damage to neighboring tissue. PMID:25145955

  17. Switching neuronal state: optimal stimuli revealed using a stochastically-seeded gradient algorithm.

    PubMed

    Chang, Joshua; Paydarfar, David

    2014-12-01

    Inducing a switch in neuronal state using energy optimal stimuli is relevant to a variety of problems in neuroscience. Analytical techniques from optimal control theory can identify such stimuli; however, solutions to the optimization problem using indirect variational approaches can be elusive in models that describe neuronal behavior. Here we develop and apply a direct gradient-based optimization algorithm to find stimulus waveforms that elicit a change in neuronal state while minimizing energy usage. We analyze standard models of neuronal behavior, the Hodgkin-Huxley and FitzHugh-Nagumo models, to show that the gradient-based algorithm: (1) enables automated exploration of a wide solution space, using stochastically generated initial waveforms that converge to multiple locally optimal solutions; and (2) finds optimal stimulus waveforms that achieve a physiological outcome condition, without a priori knowledge of the optimal terminal condition of all state variables. Analysis of biological systems using stochastically-seeded gradient methods can reveal salient dynamical mechanisms underlying the optimal control of system behavior. The gradient algorithm may also have practical applications in future work, for example, finding energy optimal waveforms for therapeutic neural stimulation that minimizes power usage and diminishes off-target effects and damage to neighboring tissue. PMID:25145955

  18. Human mastication modulated by experimental trigeminal and extra-trigeminal painful stimuli.

    PubMed

    Svensson, P; Arendt-Nielsen, L; Bjerring, P; Bak, P; Hjorth, T; Troest, T

    1996-12-01

    This paper describes the modulation of human deliberately unilateral mastication by trigeminal and extra-trigeminal standardized painful stimuli. Series with 15 s of gum-chewing before induction of pain, during pain and after pain were quantitatively assessed by jaw-closing muscle electromyography (EMG) and kinematics of the lower jaw. Four different painful stimuli were used: cold stimulation of the frontal region, cold stimulation of the dominant hand, capsaicin stimulation of the hard palate, and pressure pain stimulation of the temporomandibular joint (TMJ). Intensity and quality of perceived pain were rated on visual analogue scales (VAS) and McGill's Pain Questionnaires (MPQ). Analysis of the data showed that frontal cold stimulation was the least painful test and was associated with the fewest changes in masticatory function. Cold stimulation of the hand and palatal capsaicin stimulation caused significant increases in peak amplitudes of EMG bursts from all jaw-closing muscles and faster jaw movements whereas TMJ pressure pain produced significantly lower peak EMG amplitudes. The present results suggest that nociceptive input from different tissues and even extra-trigeminal regions may modulate trigeminal motor function in selective ways. Thus, clinical observations of changes in masticatory function may not always be due to pain in the orofacial region and therefore do not necessitate orofacial treatment. PMID:8971646

  19. Neuroticism-Anxiety, Impulsive-Sensation Seeking and autonomic responses to somatosensory stimuli.

    PubMed

    De Pascalis, Vilfredo; Valerio, Elena; Santoro, Mariacaterina; Cacace, Immacolata

    2007-01-01

    This study focused on autonomic responding in participants who scored high vs. low on the Neuroticism-Anxiety (N-Anx) and Impulsive-Sensation Seeking (Imp-SS) dimensions of the Zuckerman-Kuhlman Personality Questionnaire--Form III. Participants were presented with series of tones (standards, deviants and novels) and they received a mild electric shock (one, two or three pulses) at each 15th tone. Resting pre-stimulus skin conductance level (SCL) and heart rate (HR) level was recorded, as well as the skin conductance response (SCR) and (anticipatory) HR response to the electric stimuli. The autonomic measures differentiated between high- vs. low Imp-SS participants but failed to discriminate between high- vs. low N-Anx participants, with the exception that high N-Anx participants showed smaller SCRs on some trials compared to the low N-Anx participants. High Imp-SS had a lower pre-stimulus SCL and smaller SCRs to deviant stimuli compared to low Imp-SS participants. Additionally, their HR acceleration was smaller in anticipation of the first and the deviant tones whereas their deceleratory response was larger relative to the HR changes observed for the low Imp-SS participants. This pattern of findings was taken to suggest that high Imp-SS participants are more arousable and less prone to defensive reactions to novel or aversive stimulation. PMID:16899317

  20. Basic Emotions in the Nencki Affective Word List (NAWL BE): New Method of Classifying Emotional Stimuli

    PubMed Central

    Wierzba, Małgorzata; Riegel, Monika; Wypych, Marek; Jednoróg, Katarzyna; Turnau, Paweł; Grabowska, Anna; Marchewka, Artur

    2015-01-01

    The Nencki Affective Word List (NAWL) has recently been introduced as a standardized database of Polish words suitable for studying various aspects of language and emotions. Though the NAWL was originally based on the most commonly used dimensional approach, it is not the only way of studying emotions. Another framework is based on discrete emotional categories. Since the two perspectives are recognized as complementary, the aim of the present study was to supplement the NAWL database by the addition of categories corresponding to basic emotions. Thus, 2902 Polish words from the NAWL were presented to 265 subjects, who were instructed to rate them according to the intensity of each of the five basic emotions: happiness, anger, sadness, fear and disgust. The general characteristics of the present word database, as well as the relationships between the studied variables are shown to be consistent with typical patterns found in previous studies using similar databases for different languages. Here we present the Basic Emotions in the Nencki Affective Word List (NAWL BE) as a database of verbal material suitable for highly controlled experimental research. To make the NAWL more convenient to use, we introduce a comprehensive method of classifying stimuli to basic emotion categories. We discuss the advantages of our method in comparison to other methods of classification. Additionally, we provide an interactive online tool (http://exp.lobi.nencki.gov.pl/nawl-analysis) to help researchers browse and interactively generate classes of stimuli to meet their specific requirements. PMID:26148193

  1. A comparison of monopolar and bipolar electrical stimuli and thermal stimuli in determining the vitality of human teeth.

    PubMed

    Moody, A B; Browne, R M; Robinson, P P

    1989-01-01

    The sensory threshold was determined for 50 teeth in 31 patients using constant-current stimuli of 0.1, 1.0 and 10 ms duration at 10 Hz through both monopolar and bipolar electrodes. The teeth were also tested with a cold stimulus (ethyl chloride on cotton wool), then extracted, processed and examined by light microscopy. Histologically, 38 teeth were vital and 7 non-vital. The best prediction of vitality was from ethyl chloride (80% correct) or bipolar stimuli of 10 ms duration and up to 200 microA (73% correct). The remaining 5 teeth had vital radicular pulps and necrotic tissue coronally, but a comparison between the results of monopolar and bipolar stimulation did not permit the detection of this group. There was no correlation between the electrical threshold and presence of caries, restorations, pulp stones or diffuse pulpal mineralization. PMID:2624561

  2. Skin conductance responses to masked conditioned stimuli: phylogenetic/ontogenetic factors versus direction of threat?

    PubMed

    Flykt, Anders; Esteves, Francisco; Ohman, Arne

    2007-03-01

    Evolutionarily old threat stimuli are likely to require less conscious information processing than threat stimuli of a more recent date. To test this proposal two differential conditioning experiments, with biological threat stimuli (e.g. snakes) in half the groups and cultural threat stimuli (e.g. guns) in the other half, were conducted. The conditioned (CS+) and the control (CS-) stimuli were backward masked during the extinction phase to prevent conscious recognition. The differential skin conductance responding for both biological and cultural threat stimuli survived the masking procedure when the conditioned stimuli were directed towards the participants (Experiment 1), but for neither type of CS when stimuli were not directed towards the participants (Experiment 2). These findings are discussed in relation to the previous finding by Ohman and co-workers and in relation to imminence of threat. PMID:17049710

  3. Processing Two Dimensions of Nonspeech Stimuli: The Auditory-Phonetic Distinction Reconsidered

    ERIC Educational Resources Information Center

    Blechner, Mark J.; And Others

    1976-01-01

    Nonspeech stimuli were varied along two dimensions--intensity and rise time. In a series of speeded classification tasks, subjects were asked to identify the stimuli in terms of one of these dimensions. (Editor)

  4. Connecting massive galaxies to dark matter haloes in BOSS - I. Is galaxy colour a stochastic process in high-mass haloes?

    NASA Astrophysics Data System (ADS)

    Saito, Shun; Leauthaud, Alexie; Hearin, Andrew P.; Bundy, Kevin; Zentner, Andrew R.; Behroozi, Peter S.; Reid, Beth A.; Sinha, Manodeep; Coupon, Jean; Tinker, Jeremy L.; White, Martin; Schneider, Donald P.

    2016-08-01

    We use subhalo abundance matching (SHAM) to model the stellar mass function (SMF) and clustering of the Baryon Oscillation Spectroscopic Survey (BOSS) `CMASS' sample at z ˜ 0.5. We introduce a novel method which accounts for the stellar mass incompleteness of CMASS as a function of redshift, and produce CMASS mock catalogues which include selection effects, reproduce the overall SMF, the projected two-point correlation function wp, the CMASS dn/dz, and are made publicly available. We study the effects of assembly bias above collapse mass in the context of `age matching' and show that these effects are markedly different compared to the ones explored by Hearin et al. at lower stellar masses. We construct two models, one in which galaxy colour is stochastic (`AbM' model) as well as a model which contains assembly bias effects (`AgM' model). By confronting the redshift dependent clustering of CMASS with the predictions from our model, we argue that that galaxy colours are not a stochastic process in high-mass haloes. Our results suggest that the colours of galaxies in high-mass haloes are determined by other halo properties besides halo peak velocity and that assembly bias effects play an important role in determining the clustering properties of this sample.

  5. Evaluating Preference for Familiar and Novel Stimuli across a Large Group of Children with Autism

    ERIC Educational Resources Information Center

    Kenzer, Amy L.; Bishop, Michele R.

    2011-01-01

    This study examined relative preference for familiar and novel stimuli for 31 children with autism. Preference surveys, completed by 39 staff members, identified high and low preference familiar stimuli for each participant. Novel stimuli were selected by experimenters and included items that were not reported on a preference survey for that…

  6. Do Live versus Audio-Recorded Narrative Stimuli Influence Young Children's Narrative Comprehension and Retell Quality?

    ERIC Educational Resources Information Center

    Kim, Young-Suk Grace

    2016-01-01

    Purpose: The primary aim of the present study was to examine whether different ways of presenting narrative stimuli (i.e., live narrative stimuli versus audio-recorded narrative stimuli) influence children's performances on narrative comprehension and oral-retell quality. Method: Children in kindergarten (n = 54), second grade (n = 74), and fourth…

  7. Teaching children with autism to engage in conversational exchanges: script fading with embedded textual stimuli.

    PubMed Central

    Sarokoff, R A; Taylor, B A; Poulson, C L

    2001-01-01

    A multiple baseline across three sets of stimuli was used to assess the effects of a script-fading procedure using embedded text to teach 2 children with autism to engage in conversation statements about the stimuli. Both students stated all the scripted statements, and unscripted statements also increased. Generalization was assessed with novel peers and with untrained stimuli. PMID:11317993

  8. Understanding the Effects of Moving Visual Stimuli on Unilateral Neglect Following Stroke

    ERIC Educational Resources Information Center

    Plummer, Prudence; Dunai, Judith; Morris, Meg E.

    2006-01-01

    Moving visual stimuli have been shown to reduce unilateral neglect (ULN), however, the mechanisms underlying these effects remain poorly understood. This study compared lateralised and non-lateralised moving visual stimuli to investigate whether the spatial characteristics or general alerting properties of moving visual stimuli are responsible for…

  9. Assessment of the Relatedness of Equivalent Stimuli through a Semantic Differential

    ERIC Educational Resources Information Center

    Bortoloti, Renato; de Rose, Julio C.

    2009-01-01

    If stimulus equivalence is a model of meaning, abstract stimuli should acquire the meaning of meaningful stimuli equivalent to them. In Experiment 1, college students matched faces expressing emotions to arbitrary pictures, forming three classes of equivalent stimuli, each comprising an emotional expression and three arbitrary pictures. Semantic…

  10. PC-compatible computer-generated stimuli for video-task testing

    NASA Technical Reports Server (NTRS)

    Washburn, David A.

    1990-01-01

    A program for automatic computer generation of novel nonverbal stimuli is described. The program, STIMGEN, allows menu-driven control over the type and appearance of stimuli. Data are presented in which two monkeys matched to sample with high accuracy using stimuli generated with STIMGEN. These data are interpreted to support the usefulness and value of automatic stimulus generation in a variety of applications.

  11. Freezing Behavior as a Response to Sexual Visual Stimuli as Demonstrated by Posturography

    PubMed Central

    Mouras, Harold; Lelard, Thierry; Ahmaidi, Said; Godefroy, Olivier; Krystkowiak, Pierre

    2015-01-01

    Posturographic changes in motivational conditions remain largely unexplored in the context of embodied cognition. Over the last decade, sexual motivation has been used as a good canonical working model to study motivated social interactions. The objective of this study was to explore posturographic variations in response to visual sexual videos as compared to neutral videos. Our results support demonstration of a freezing-type response in response to sexually explicit stimuli compared to other conditions, as demonstrated by significantly decreased standard deviations for (i) the center of pressure displacement along the mediolateral and anteroposterior axes and (ii) center of pressure’s displacement surface. These results support the complexity of the motor correlates of sexual motivation considered to be a canonical functional context to study the motor correlates of motivated social interactions. PMID:25992571

  12. A dual-stimuli-responsive fluorescent switch ultrathin film

    NASA Astrophysics Data System (ADS)

    Li, Zhixiong; Liang, Ruizheng; Liu, Wendi; Yan, Dongpeng; Wei, Min

    2015-10-01

    Stimuli-responsive fluorescent switches have shown broad applications in optical devices, biological materials and intelligent responses. Herein, we describe the design and fabrication of a dual-stimuli-responsive fluorescent switch ultrathin film (UTF) via a three-step layer-by-layer (LBL) technique: (i) encapsulation of spiropyran (SP) within an amphiphilic block copolymer (PTBEM) to give the (SP@PTBEM) micelle; (ii) the mixture of riboflavin (Rf) and poly(styrene 4-sulfonate) (PSS) to enhance the adhesion ability of small molecules; (iii) assembly of negatively charged SP@PTBEM and Rf-PSS with cationic layered double hydroxide (LDH) nanoplatelets to obtain the (Rf-PSS/LDH/SP@PTBEM)n UTFs (n: bilayer number). The assembly process of the UTFs and their luminescence properties, as monitored by fluorescence spectroscopy and scanning electron microscopy (SEM), present a uniform and ordered layered structure with stepwise growth. The resulting Rf-PSS/LDH/SP@PTBEM UTF serves as a three-state switchable multicolor (green, yellow, and red) luminescent system based on stimulation from UV/Vis light and pH, with an acceptable reversibility. Therefore, this work provides a facile way to fabricate stimuli-responsive solid-state film switches with tunable-color luminescence, which have potential applications in the areas of displays, sensors, and rewritable optical memory and fluorescent logic devices.Stimuli-responsive fluorescent switches have shown broad applications in optical devices, biological materials and intelligent responses. Herein, we describe the design and fabrication of a dual-stimuli-responsive fluorescent switch ultrathin film (UTF) via a three-step layer-by-layer (LBL) technique: (i) encapsulation of spiropyran (SP) within an amphiphilic block copolymer (PTBEM) to give the (SP@PTBEM) micelle; (ii) the mixture of riboflavin (Rf) and poly(styrene 4-sulfonate) (PSS) to enhance the adhesion ability of small molecules; (iii) assembly of negatively charged SP

  13. Modulating the processing of emotional stimuli by cognitive demand.

    PubMed

    Kellermann, Tanja S; Sternkopf, Melanie A; Schneider, Frank; Habel, Ute; Turetsky, Bruce I; Zilles, Karl; Eickhoff, Simon B

    2012-03-01

    Emotional processing is influenced by cognitive processes and vice versa, indicating a profound interaction of these domains. The investigation of the neural mechanisms underlying this interaction is not only highly relevant for understanding the organization of human brain function. Rather, it may also help in understanding dysregulated emotions in affective disorders and in elucidating the neurobiology of cognitive behavioural therapy (e.g. in borderline personality disorder), which aims at modulating dysfunctional emotion processes by cognitive techniques, such as restructuring. In the majority of earlier studies investigating the interaction of emotions and cognition, the main focus has been on the investigation of the effects of emotional stimuli or, more general, emotional processing, e.g. instituted by emotional material that needed to be processed, on cognitive performance and neural activation patterns. Here we pursued the opposite approach and investigated the modulation of implicit processing of emotional stimuli by cognitive demands using an event-related functional magnetic resonance imaging--study on a motor short-term memory paradigm with emotional interferences. Subjects were visually presented a finger-sequence consisting either of four (easy condition) or six (difficult condition) items, which they had to memorize. After a short pause positive, negative or neutral International affective picture system pictures or a green dot (as control condition) were presented. Subjects were instructed to reproduce the memorized sequence manually as soon as the picture disappeared. Analysis showed that with increasing cognitive demand (long relative to short sequences), neural responses to emotional pictures were significantly reduced in amygdala and orbitofrontal cortex. In contrast, the more difficult task evoked stronger activation in a widespread frontoparietal network. As stimuli were task-relevant go-cues and hence had to be processed perceptually, we

  14. Parasympathetic Stimuli on Bronchial and Cardiovascular Systems in Humans

    PubMed Central

    Zannin, Emanuela; Pellegrino, Riccardo; Di Toro, Alessandro; Antonelli, Andrea; Dellacà, Raffaele L.; Bernardi, Luciano

    2015-01-01

    Background It is not known whether parasympathetic outflow simultaneously acts on bronchial tone and cardiovascular system waxing and waning both systems in parallel, or, alternatively, whether the regulation is more dependent on local factors and therefore independent on each system. The aim of this study was to evaluate the simultaneous effect of different kinds of stimulations, all associated with parasympathetic activation, on bronchomotor tone and cardiovascular autonomic regulation. Methods Respiratory system resistance (Rrs, forced oscillation technique) and cardio-vascular activity (heart rate, oxygen saturation, tissue oxygenation index, blood pressure) were assessed in 13 volunteers at baseline and during a series of parasympathetic stimuli: O2 inhalation, stimulation of the carotid sinus baroreceptors by neck suction, slow breathing, and inhalation of methacholine. Results Pure cholinergic stimuli, like O2 inhalation and baroreceptors stimulation, caused an increase in Rrs and a reduction in heart rate and blood pressure. Slow breathing led to bradycardia and hypotension, without significant changes in Rrs. However slow breathing was associated with deep inhalations, and Rrs evaluated at the baseline lung volumes was significantly increased, suggesting that the large tidal volumes reversed the airways narrowing effect of parasympathetic activation. Finally inhaled methacholine caused marked airway narrowing, while the cardiovascular variables were unaffected, presumably because of the sympathetic activity triggered in response to hypoxemia. Conclusions All parasympathetic stimuli affected bronchial tone and moderately affected also the cardiovascular system. However the response differed depending on the nature of the stimulus. Slow breathing was associated with large tidal volumes that reversed the airways narrowing effect of parasympathetic activation. PMID:26046774

  15. Regional brain responses in nulliparous women to emotional infant stimuli.

    PubMed

    Montoya, Jessica L; Landi, Nicole; Kober, Hedy; Worhunsky, Patrick D; Rutherford, Helena J V; Mencl, W Einar; Mayes, Linda C; Potenza, Marc N

    2012-01-01

    Infant cries and facial expressions influence social interactions and elicit caretaking behaviors from adults. Recent neuroimaging studies suggest that neural responses to infant stimuli involve brain regions that process rewards. However, these studies have yet to investigate individual differences in tendencies to engage or withdraw from motivationally relevant stimuli. To investigate this, we used event-related fMRI to scan 17 nulliparous women. Participants were presented with novel infant cries of two distress levels (low and high) and unknown infant faces of varying affect (happy, sad, and neutral) in a randomized, counter-balanced order. Brain activation was subsequently correlated with scores on the Behavioral Inhibition System/Behavioral Activation System scale. Infant cries activated bilateral superior and middle temporal gyri (STG and MTG) and precentral and postcentral gyri. Activation was greater in bilateral temporal cortices for low- relative to high-distress cries. Happy relative to neutral faces activated the ventral striatum, caudate, ventromedial prefrontal, and orbitofrontal cortices. Sad versus neutral faces activated the precuneus, cuneus, and posterior cingulate cortex, and behavioral activation drive correlated with occipital cortical activations in this contrast. Behavioral inhibition correlated with activation in the right STG for high- and low-distress cries relative to pink noise. Behavioral drive correlated inversely with putamen, caudate, and thalamic activations for the comparison of high-distress cries to pink noise. Reward-responsiveness correlated with activation in the left precentral gyrus during the perception of low-distress cries relative to pink noise. Our findings indicate that infant cry stimuli elicit activations in areas implicated in auditory processing and social cognition. Happy infant faces may be encoded as rewarding, whereas sad faces activate regions associated with empathic processing. Differences in motivational

  16. Napping Promotes Inter-Session Habituation to Emotional Stimuli

    PubMed Central

    Pace-Schott, Edward F.; Shepherd, Elizabeth; Spencer, Rebecca M.C.; Marcello, Matthew; Tucker, Matthew; Propper, Ruth E.; Stickgold, Robert

    2010-01-01

    The effects of a daytime nap on inter-session habituation to aversive visual stimuli were investigated. Healthy young adult volunteers viewed repeated presentations of highly negative and emotionally neutral (but equally arousing) International Affective Picture System (IAPS) photographs during two afternoon sessions separated by 2.5 hrs. Half of the photographs were shown at both sessions (Repeated Sets) and half differed between sessions (Novel Sets). For each stimulus presentation, evoked skin conductance response (SCR), heart rate deceleration (HRD) and corrugator supercilii EMG response (EMG), were computed and range corrected using respective maximum session-1 responses. Following each presentation, subjects rated each photograph on dimensions of pleasantness and arousability. During the inter-session interval, Nap subjects had a 120-min polysomnographically monitored sleep opportunity, whereas Wake subjects watched a non-stimulating video. Nap and Wake subjects did not differ in their subjective ratings of photographs. However, for Repeated-Set photographs, Nap subjects demonstrated greater inter-session habituation in SCR and EMG but a trend toward lesser inter-session habituation in HRD. These group differences were absent for Novel-Set photographs. Group differences across all measures were greater for negative stimuli. Occurrence of SWS during the nap was associated with greater inter-session habituation of EMG whereas occurrence of REM was associated with lesser inter-session habituation of SCR to negative stimuli. Sleep may therefore promote emotional adjustment at the level of somatic responses. Physiological but not subjective inter-session habituation to aversive images was enhanced by a daytime nap. PMID:20969968

  17. Impact of Emotion on Consciousness: Positive Stimuli Enhance Conscious Reportability

    PubMed Central

    Rømer Thomsen, Kristine; Lou, Hans C.; Joensson, Morten; Hyam, Jonathan A.; Holland, Peter; Parsons, Christine E.; Young, Katherine S.; Møller, Arne; Stein, Alan; Green, Alex L.; Kringelbach, Morten L.; Aziz, Tipu Z.

    2011-01-01

    Emotion and reward have been proposed to be closely linked to conscious experience, but empirical data are lacking. The anterior cingulate cortex (ACC) plays a central role in the hedonic dimension of conscious experience; thus potentially a key region in interactions between emotion and consciousness. Here we tested the impact of emotion on conscious experience, and directly investigated the role of the ACC. We used a masked paradigm that measures conscious reportability in terms of subjective confidence and objective accuracy in identifying the briefly presented stimulus in a forced-choice test. By manipulating the emotional valence (positive, neutral, negative) and the presentation time (16 ms, 32 ms, 80 ms) we measured the impact of these variables on conscious and subliminal (i.e. below threshold) processing. First, we tested normal participants using face and word stimuli. Results showed that participants were more confident and accurate when consciously seeing happy versus sad/neutral faces and words. When stimuli were presented subliminally, we found no effect of emotion. To investigate the neural basis of this impact of emotion, we recorded local field potentials (LFPs) directly in the ACC in a chronic pain patient. Behavioural findings were replicated: the patient was more confident and accurate when (consciously) seeing happy versus sad faces, while no effect was seen in subliminal trials. Mirroring behavioural findings, we found significant differences in the LFPs after around 500 ms (lasting 30 ms) in conscious trials between happy and sad faces, while no effect was found in subliminal trials. We thus demonstrate a striking impact of emotion on conscious experience, with positive emotional stimuli enhancing conscious reportability. In line with previous studies, the data indicate a key role of the ACC, but goes beyond earlier work by providing the first direct evidence of interaction between emotion and conscious experience in the human ACC. PMID

  18. Hydrophilic-oleophobic stimuli-responsive materials and surfaces

    NASA Astrophysics Data System (ADS)

    Howarter, John A.

    Due to their high surface energy, hydrophilic surfaces are susceptible to contamination which is difficult to remove and often ruins the surface. Hydrophilic-oleophobic coatings have a diverse engineering potential including applications as self-cleaning surfaces, extended life anti-fog coatings, and environmental remediation in the selective filtration of oil-in-water mixtures. A successful design model for hydrophilic-oleophobic behavior has been developed using perfluorinated surfactants covalently bound to a surface. Within this design model, a variety of materials have been explored which the surfactants are covalently bound to a substrate; similarly, the surfactants may also be incorporated as a monomer into bulk copolymers. Surfactant based surfaces exhibited simultaneous hydrophilicity, necessary for anti-fogging, and oleophobicity, necessary for contamination resistance. The combination of these features rendered the surface as self-cleaning. Surfactant based brushes, composed of polyethylene glycol and perfluorinated constituents were grafted on to silica surfaces. The relationship between brush density and stimuli-responsiveness was determined by varying grafting conditions. The resultant surfaces were characterized with respect to chemical composition, brush thickness, and wetting behavior of water and hexadecane. Optimized surfaces exhibited stimuli-responsive behavior such that the surfaces will be wetted by water but not by oil. Surfactants were incorporated into random copolymers to create self-cleaning polymers which could be easily coated on to surfaces post-synthesis. Acrylic acid, methyl methacrylate, and hydroxyethyl methacrylate were used as comonomers; feed ratio was varied to establish compositional limits of stimuli-responsive behavior. Polymer composition dictated coating durability and self-cleaning performance as determined by water and hexadecane contact angle. The ability of select coatings to mitigate fogging was assessed in two

  19. Searching for optimal stimuli: ascending a neuron's response function.

    PubMed

    Koelling, Melinda Evrithiki; Nykamp, Duane Q

    2012-12-01

    Many methods used to analyze neuronal response assume that neuronal activity has a fundamentally linear relationship to the stimulus. However, some neurons are strongly sensitive to multiple directions in stimulus space and have a highly nonlinear response. It can be difficult to find optimal stimuli for these neurons. We demonstrate how successive linear approximations of neuronal response can effectively carry out gradient ascent and move through stimulus space towards local maxima of the response. We demonstrate search results for a simple model neuron and two models of a highly selective neuron. PMID:22580579

  20. [Separation of certain local stimuli on a nerve net].

    PubMed

    Gutman, S R

    1980-01-01

    Possibility for discerning a local stimulus (monochromatic colour, pure tone, injection etc), and the evaluation of the stimulus closeness to the local one on the neuron net were shown earlier. The present work solves the problem of discerning the signal composed of several local stimuli, which allows to approximate the initial signal by the sum Gaussian. The results explain possible evaluation of overtones of the sound signal and similar psychophysical effects. A model is described of "tuning" the receptor to one of several simultaneously acting signals produced by different sources. The structure of the neuron nets which realize the problems under analysis is discussed. PMID:7417579

  1. On hemispheric differences in evoked potentials to speech stimuli

    NASA Technical Reports Server (NTRS)

    Galambos, R.; Smith, T. S.; Schulman-Galambos, C.; Osier, H.; Benson, P.

    1975-01-01

    Subjects were asked to count the number of times a 'target' sound occurred in lists of speech sounds (pa or ba) or pure tones (250 or 600 c/sec) in which one of the sounds (the 'frequent') appeared about four times as often as the target. The response to both targets and frequents were separately averaged from electrodes at vertex at symmetrical left and right parietal locations. The expected sequence of deflections, including P3 waves with about 350 msec latency, was found in the responses to target stimuli. Very little difference was found between the right and left hemispheric responses to speech or pure tones, either frequent or target.

  2. Post-training re-exposure to fear conditioned stimuli enhances memory consolidation and biases rats toward the use of dorsolateral striatum-dependent response learning.

    PubMed

    Leong, Kah-Chung; Goodman, Jarid; Packard, Mark G

    2015-09-15

    In a dual-solution task that can be acquired using either hippocampus-dependent "place" or dorsolateral striatum-dependent "response" learning, emotional arousal induced by unconditioned stimuli (e.g. anxiogenic drug injections or predator odor exposure) biases rats toward response learning. In the present experiments emotionally-arousing conditioned stimuli were used to modulate the relative use of multiple memory systems. In Experiment 1, adult male Long-Evans rats initially received three standard fear-conditioning trials in which a tone (2 kHz, 75 dB) was paired with a brief electrical shock (1 mA, 2s). On day 2, the rats were trained in a dual-solution plus-maze task to swim from the same start arm (South) to a hidden escape platform always located in the same goal arm (East). Immediately following training, rats received post-training re-exposure to the fear-conditioned stimuli (i.e. tone and context) without shock. On day 3, the relative use of place or response learning was assessed on a probe trial in which rats were started from the opposite start arm (North). Post-training re-exposure to fear-conditioned stimuli produced preferential use of a response strategy. In Experiment 2, different rats received fear conditioning and were then trained in a single-solution task that required the use of response learning. Immediately following training, rats received post-training re-exposure to the fear-conditioned stimuli without shock. Re-exposure to fear-conditioned stimuli enhanced memory consolidation in the response learning task. Thus, re-exposure to fear-conditioned stimuli biases rats toward the use of dorsolateral striatum-dependent response learning and enhances memory consolidation of response learning. PMID:26005126

  3. Klinefelter syndrome has increased brain responses to auditory stimuli and motor output, but not to visual stimuli or Stroop adaptation

    PubMed Central

    Wallentin, Mikkel; Skakkebæk, Anne; Bojesen, Anders; Fedder, Jens; Laurberg, Peter; Østergaard, John R.; Hertz, Jens Michael; Pedersen, Anders Degn; Gravholt, Claus Højbjerg

    2016-01-01

    Klinefelter syndrome (47, XXY) (KS) is a genetic syndrome characterized by the presence of an extra X chromosome and low level of testosterone, resulting in a number of neurocognitive abnormalities, yet little is known about brain function. This study investigated the fMRI-BOLD response from KS relative to a group of Controls to basic motor, perceptual, executive and adaptation tasks. Participants (N: KS = 49; Controls = 49) responded to whether the words “GREEN” or “RED” were displayed in green or red (incongruent versus congruent colors). One of the colors was presented three times as often as the other, making it possible to study both congruency and adaptation effects independently. Auditory stimuli saying “GREEN” or “RED” had the same distribution, making it possible to study effects of perceptual modality as well as Frequency effects across modalities. We found that KS had an increased response to motor output in primary motor cortex and an increased response to auditory stimuli in auditory cortices, but no difference in primary visual cortices. KS displayed a diminished response to written visual stimuli in secondary visual regions near the Visual Word Form Area, consistent with the widespread dyslexia in the group. No neural differences were found in inhibitory control (Stroop) or in adaptation to differences in stimulus frequencies. Across groups we found a strong positive correlation between age and BOLD response in the brain's motor network with no difference between groups. No effects of testosterone level or brain volume were found. In sum, the present findings suggest that auditory and motor systems in KS are selectively affected, perhaps as a compensatory strategy, and that this is not a systemic effect as it is not seen in the visual system. PMID:26958463

  4. Klinefelter syndrome has increased brain responses to auditory stimuli and motor output, but not to visual stimuli or Stroop adaptation.

    PubMed

    Wallentin, Mikkel; Skakkebæk, Anne; Bojesen, Anders; Fedder, Jens; Laurberg, Peter; Østergaard, John R; Hertz, Jens Michael; Pedersen, Anders Degn; Gravholt, Claus Højbjerg

    2016-01-01

    Klinefelter syndrome (47, XXY) (KS) is a genetic syndrome characterized by the presence of an extra X chromosome and low level of testosterone, resulting in a number of neurocognitive abnormalities, yet little is known about brain function. This study investigated the fMRI-BOLD response from KS relative to a group of Controls to basic motor, perceptual, executive and adaptation tasks. Participants (N: KS = 49; Controls = 49) responded to whether the words "GREEN" or "RED" were displayed in green or red (incongruent versus congruent colors). One of the colors was presented three times as often as the other, making it possible to study both congruency and adaptation effects independently. Auditory stimuli saying "GREEN" or "RED" had the same distribution, making it possible to study effects of perceptual modality as well as Frequency effects across modalities. We found that KS had an increased response to motor output in primary motor cortex and an increased response to auditory stimuli in auditory cortices, but no difference in primary visual cortices. KS displayed a diminished response to written visual stimuli in secondary visual regions near the Visual Word Form Area, consistent with the widespread dyslexia in the group. No neural differences were found in inhibitory control (Stroop) or in adaptation to differences in stimulus frequencies. Across groups we found a strong positive correlation between age and BOLD response in the brain's motor network with no difference between groups. No effects of testosterone level or brain volume were found. In sum, the present findings suggest that auditory and motor systems in KS are selectively affected, perhaps as a compensatory strategy, and that this is not a systemic effect as it is not seen in the visual system. PMID:26958463

  5. Emotional stimuli exert parallel effects on attention and memory.

    PubMed

    Talmi, Deborah; Ziegler, Marilyne; Hawksworth, Jade; Lalani, Safina; Herman, C Peter; Moscovitch, Morris

    2013-01-01

    Because emotional and neutral stimuli typically differ on non-emotional dimensions, it has been difficult to determine conclusively which factors underlie the ability of emotional stimuli to enhance immediate long-term memory. Here we induced arousal by varying participants' goals, a method that removes many potential confounds between emotional and non-emotional items. Hungry and sated participants encoded food and clothing images under divided attention conditions. Sated participants attended to and recalled food and clothing images equivalently. Hungry participants performed worse on the concurrent tone-discrimination task when they viewed food relative to clothing images, suggesting enhanced attention to food images, and they recalled more food than clothing images. A follow-up regression analysis of the factors predicting memory for individual pictures revealed that food images had parallel effects on attention and memory in hungry participants, so that enhanced attention to food images did not predict their enhanced memory. We suggest that immediate long-term memory for food is enhanced in the hungry state because hunger leads to more distinctive processing of food images rendering them more accessible during retrieval. PMID:22974274

  6. Response time to colored stimuli in the full visual field

    NASA Technical Reports Server (NTRS)

    Haines, R. F.; Dawson, L. M.; Galvan, T.; Reid, L. M.

    1975-01-01

    Peripheral visual response time was measured in seven dark adapted subjects to the onset of small (45' arc diam), brief (50 msec), colored (blue, yellow, green, red) and white stimuli imaged at 72 locations within their binocular field of view. The blue, yellow, and green stimuli were matched for brightness at about 2.6 sub log 10 units above their absolute light threshold, and they appeared at an unexpected time and location. These data were obtained to provide response time and no-response data for use in various design disciplines involving instrument panel layout. The results indicated that the retina possesses relatively concentric regions within each of which mean response time can be expected to be of approximately the same duration. These regions are centered near the fovea and extend farther horizontally than vertically. Mean foveal response time was fastest for yellow and slowest for blue. Three and one-half percent of the total 56,410 trials presented resulted in no-responses. Regardless of stimulus color, the lowest percentage of no-responses occurred within 30 deg arc from the fovea and the highest within 40 deg to 80 deg arc below the fovea.

  7. EEG Responses to Auditory Stimuli for Automatic Affect Recognition

    PubMed Central

    Hettich, Dirk T.; Bolinger, Elaina; Matuz, Tamara; Birbaumer, Niels; Rosenstiel, Wolfgang; Spüler, Martin

    2016-01-01

    Brain state classification for communication and control has been well established in the area of brain-computer interfaces over the last decades. Recently, the passive and automatic extraction of additional information regarding the psychological state of users from neurophysiological signals has gained increased attention in the interdisciplinary field of affective computing. We investigated how well specific emotional reactions, induced by auditory stimuli, can be detected in EEG recordings. We introduce an auditory emotion induction paradigm based on the International Affective Digitized Sounds 2nd Edition (IADS-2) database also suitable for disabled individuals. Stimuli are grouped in three valence categories: unpleasant, neutral, and pleasant. Significant differences in time domain domain event-related potentials are found in the electroencephalogram (EEG) between unpleasant and neutral, as well as pleasant and neutral conditions over midline electrodes. Time domain data were classified in three binary classification problems using a linear support vector machine (SVM) classifier. We discuss three classification performance measures in the context of affective computing and outline some strategies for conducting and reporting affect classification studies. PMID:27375410

  8. Genetically engineered protein in hydrogels tailors stimuli-responsive characteristics

    NASA Astrophysics Data System (ADS)

    Ehrick, Jason D.; Deo, Sapna K.; Browning, Tyler W.; Bachas, Leonidas G.; Madou, Marc J.; Daunert, Sylvia

    2005-04-01

    Certain proteins undergo a substantial conformational change in response to a given stimulus. This conformational change can manifest in different manners and result in an actuation, that is, catalytic or signalling event, movement, interaction with other proteins, and so on. In all cases, the sensing-actuation process of proteins is initiated by a recognition event that translates into a mechanical action. Thus, proteins are ideal components for designing new nanomaterials that are intelligent and can perform desired mechanical actions in response to target stimuli. A number of approaches have been undertaken to mimic nature's sensing-actuating process. We now report a new hybrid material that integrates genetically engineered proteins within hydrogels capable of producing a stimulus-responsive action mechanism. The mechanical effect is a result of an induced conformational change and binding affinities of the protein in response to a stimulus. The stimuli-responsive hydrogel exhibits three specific swelling stages in response to various ligands offering additional fine-tuned control over a conventional two-stage swelling hydrogel. The newly prepared material was used in the sensing, and subsequent gating and transport of biomolecules across a polymer network, demonstrating its potential application in microfluidics and miniaturized drug-delivery systems.

  9. Food-associated Stimuli Enhance Barrier Properties of Gastrointestinal Mucus

    PubMed Central

    Yildiz, Hasan M.; Speciner, Lauren; Ozdemir, Cafer; Cohen, David E.; Carrier, Rebecca L.

    2015-01-01

    Orally delivered drugs and nutrients must diffuse through mucus to enter the circulatory system, but the barrier properties of mucus and their modulation by physiological factors are generally poorly characterized. The main objective of this study was to examine the impact of physicochemical changes occurring upon food ingestion on gastrointestinal (GI) mucus barrier properties. Lipids representative of postprandial intestinal contents enhanced mucus barriers, as indicated by a 10 – 142-fold reduction in the transport rate of 200 nm microspheres through mucus, depending on surface chemistry. Physiologically relevant increases in [Ca2+] resulted in a 2 - 4-fold reduction of transport rates, likely due to enhanced cross-linking of the mucus gel network. Reduction of pH from 6.5 to 3.5 also affected mucus viscoelasticity, reducing particle transport rates approximately 5 – 10-fold. Macroscopic visual observation and micro-scale lectin staining revealed mucus gel structural changes, including clumping into regions into which particles did not penetrate. Histological examination indicated food ingestion can prevent microsphere contact with and endocytosis by intestinal epithelium. Taken together, these results demonstrate that GI mucus barriers are significantly altered by stimuli associated with eating and potentially dosing of lipid-based delivery systems; these stimuli represent broadly relevant variables to consider upon designing oral therapies. PMID:25907034

  10. Healable thermoset polymer composite embedded with stimuli-responsive fibres

    PubMed Central

    Li, Guoqiang; Meng, Harper; Hu, Jinlian

    2012-01-01

    Severe wounds in biological systems such as human skin cannot heal themselves, unless they are first stitched together. Healing of macroscopic damage in thermoset polymer composites faces a similar challenge. Stimuli-responsive shape-changing polymeric fibres with outstanding mechanical properties embedded in polymers may be able to close macro-cracks automatically upon stimulation such as heating. Here, a stimuli-responsive fibre (SRF) with outstanding mechanical properties and supercontraction capability was fabricated for the purpose of healing macroscopic damage. The SRFs and thermoplastic particles (TPs) were incorporated into regular thermosetting epoxy for repeatedly healing macroscopic damages. The system works by mimicking self-healing of biological systems such as human skin, close (stitch) then heal, i.e. close the macroscopic crack through the thermal-induced supercontraction of the SRFs, and bond the closed crack through melting and diffusing of TPs at the crack interface. The healing efficiency determined using tapered double-cantilever beam specimens was 94 per cent. The self-healing process was reasonably repeatable. PMID:22896563

  11. Preferences for and against stimuli paired with food.

    PubMed Central

    Mazur, J E

    1999-01-01

    Pigeons were presented with a concurrent-chains schedule in which terminal-link entries were assigned to two response keys on a percentage basis. The terminal links were fixed delays that sometimes ended with food and sometimes did not. In most conditions, 80% of the terminal links were assigned to one key, but a smaller percentage of the terminal links ended with food for this key, so the number of food reinforcers delivered by the two alternatives was equal. When the same terminal-link stimuli (orange houselights) were used for both alternatives, the pigeons showed a preference for whichever alternative delivered more frequent terminal links. When different terminal-link stimuli (green vs. red houselights) were used for the two alternatives, the pigeons showed a preference for whichever alternative delivered fewer terminal links when terminal-link durations were long, and no systematic preferences when terminal-link durations were short. This pattern of results was consistent with the predictions of Grace's (1994) contextual choice model. Preference for the alternative that delivered more frequent terminal links was usually stronger in the first few sessions of a condition than at the end of a condition, suggesting that the conditioned reinforcing effect of the additional terminal-link presentation was, in part, transitory. PMID:10418156

  12. Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery.

    PubMed

    Alvarez-Lorenzo, Carmen; Blanco-Fernandez, Barbara; Puga, Ana M; Concheiro, Angel

    2013-08-01

    Polysaccharides are gaining increasing attention as components of stimuli-responsive drug delivery systems, particularly since they can be obtained in a well characterized and reproducible way from the natural sources. Ionic polysaccharides can be readily crosslinked to render hydrogel networks sensitive to a variety of internal and external variables, and thus suitable for switching drug release on-off through diverse mechanisms. Hybrids, composites and grafted polymers can reinforce the responsiveness and widen the range of stimuli to which polysaccharide-based systems can respond. This review analyzes the state of the art of crosslinked ionic polysaccharides as components of delivery systems that can regulate drug release as a function of changes in pH, ion nature and concentration, electric and magnetic field intensity, light wavelength, temperature, redox potential, and certain molecules (enzymes, illness markers, and so on). Examples of specific applications are provided. The information compiled demonstrates that crosslinked networks of ionic polysaccharides are suitable building blocks for developing advanced externally activated and feed-back modulated drug delivery systems. PMID:23639519

  13. Nonconvulsive status epilepticus in rats: impaired responsiveness to exteroceptive stimuli.

    PubMed

    Mikulecká, A; Krsek, P; Hlinák, Z; Druga, R; Mares, P

    2000-12-20

    An animal model of human complex partial status epilepticus induced by lithium chloride and pilocarpine administration was developed in our laboratory. The objective of the study was to provide a detailed analysis of both ictal and postictal behavior and to quantify seizure-related morphological damage. In order to determine the animal's responsiveness to either visual or olfactory stimuli, adult male rats were submitted to the following behavioral paradigms: the object response test, the social interaction test, and the elevated plus-maze test. The rotorod test was used to evaluate motor performance. Two weeks after status epilepticus, brains were morphologically examined and quantification of the brain damage was performed. Profound impairment of behavior as well as responsiveness to exteroceptive stimuli correlated with the occurrence of epileptic EEG activity. When the epileptic EEG activity ceased, responsiveness of the pilocarpine-treated animals was renewed. However, remarkable morphological damage persisted in the cortical regions two weeks later. This experimental study provides support for the clinical evidence that even nonconvulsive epileptic activity may cause brain damage. We suggest that the model can be used for the study of both functional and morphological consequences of prolonged nonconvulsive seizures. PMID:11099755

  14. Food-associated stimuli enhance barrier properties of gastrointestinal mucus.

    PubMed

    Yildiz, Hasan M; Speciner, Lauren; Ozdemir, Cafer; Cohen, David E; Carrier, Rebecca L

    2015-06-01

    Orally delivered drugs and nutrients must diffuse through mucus to enter the circulatory system, but the barrier properties of mucus and their modulation by physiological factors are generally poorly characterized. The main objective of this study was to examine the impact of physicochemical changes occurring upon food ingestion on gastrointestinal (GI) mucus barrier properties. Lipids representative of postprandial intestinal contents enhanced mucus barriers, as indicated by a 10-142-fold reduction in the transport rate of 200 nm microspheres through mucus, depending on surface chemistry. Physiologically relevant increases in [Ca(2+)] resulted in a 2-4-fold reduction of transport rates, likely due to enhanced cross-linking of the mucus gel network. Reduction of pH from 6.5 to 3.5 also affected mucus viscoelasticity, reducing particle transport rates approximately 5-10-fold. Macroscopic visual observation and micro-scale lectin staining revealed mucus gel structural changes, including clumping into regions into which particles did not penetrate. Histological examination indicated food ingestion can prevent microsphere contact with and endocytosis by intestinal epithelium. Taken together, these results demonstrate that GI mucus barriers are significantly altered by stimuli associated with eating and potentially dosing of lipid-based delivery systems; these stimuli represent broadly relevant variables to consider upon designing oral therapies. PMID:25907034

  15. Task attention facilitates learning of task-irrelevant stimuli.

    PubMed

    Huang, Tsung-Ren; Watanabe, Takeo

    2012-01-01

    Attention plays a fundamental role in visual learning and memory. One highly established principle of visual attention is that the harder a central task is, the more attentional resources are used to perform the task and the smaller amount of attention is allocated to peripheral processing because of limited attention capacity. Here we show that this principle holds true in a dual-task setting but not in a paradigm of task-irrelevant perceptual learning. In Experiment 1, eight participants were asked to identify either bright or dim number targets at the screen center and to remember concurrently presented scene backgrounds. Their recognition performances for scenes paired with dim/hard targets were worse than those for scenes paired with bright/easy targets. In Experiment 2, eight participants were asked to identify either bright or dim letter targets at the screen center while a task-irrelevant coherent motion was concurrently presented in the background. After five days of training on letter identification, participants improved their motion sensitivity to the direction paired with hard/dim targets improved but not to the direction paired with easy/bright targets. Taken together, these results suggest that task-irrelevant stimuli are not subject to the attentional control mechanisms that task-relevant stimuli abide. PMID:22563424

  16. Polymer-based stimuli-responsive nanosystems for biomedical applications.

    PubMed

    Joglekar, Madhura; Trewyn, Brian G

    2013-08-01

    The application of organic polymers and inorganic/organic hybrid systems in numerous fields of biotechnology has seen a considerable growth in recent years. Typically, organic polymers with diverse structures, compositional variations and differing molecular weights have been utilized to assemble polymeric nanosystems such as polymeric micelles, polymersomes, and nanohydrogels with unique features and structural properties. The architecture of these polymeric nanosystems involves the use of both hydrophobic and hydrophilic polymeric blocks, making them suitable as vehicles for diagnostic and therapeutic applications. Recently, "smart" or "intelligent" polymers have attracted significant attention in the biomedical field wherein careful introduction of specific polymeric modalities changes a banal polymeric nanosystem to an advanced stimuli-responsive nanosystem capable of performing extraordinary functions in response to an internal or external trigger such as pH, temperature, redox, enzymes, light, magnetic, or ultrasound. Further, incorporation of inorganic nanoparticles such as gold, silica, or iron oxide with surface-bound stimuli-responsive polymers offers additional advantages and multifunctionality in the field of nanomedicine. This review covers the physical properties and applications of both organic and organic/inorganic hybrid nanosystems with specific recent breakthroughs in drug delivery, imaging, tissue engineering, and separations and provides a brief discussion on the future direction. PMID:23843342

  17. Effects of vasoactive stimuli on blood flow to choroid plexus

    SciTech Connect

    Faraci, F.M.; Mayhan, W.G.; Williams, J.K.; Heistad, D.D. )

    1988-02-01

    The goal of this study was to examine effects of vasoactive stimuli on blood flow to choroid plexus. The authors used microspheres to measure blood flow to choroid plexus and cerebrum in anesthetized dogs and rabbits. A critical assumption of the microsphere method is that microspheres do not pass through arteriovenous shunts. Blood flow values obtained with simultaneous injection of 15- and 50-{mu}m microspheres were similar, which suggest that shunting of 15-{mu}m microspheres was minimal. Blood flow to choroid plexus under control conditions was 287 {plus minus} 26 (means {plus minus} SE) ml {center dot} min{sup {minus}1} {center dot} 100 g{sup {minus}1} in dogs and 385 {plus minus} 73 ml {center dot} min{sup {minus}1} 100 g{sup {minus}1} in rabbits. Consecutive measurements under control conditions indicated that values for blood flow are reproducible. Adenosine did not alter blood flow to cerebrum but increased blood flow to choroid plexus two- to threefold in dogs and rabbits. Norepinephrine and phenylephrine did not affect blood flow to choroid plexus and cerebrum but decreased blood flow to choroid plexus by {approx} 50%. The authors suggest that (1) the microsphere method provides reproducible valid measurements of blood flow to the choroid plexus in dogs and rabbits and (2) vasoactive stimuli may have profoundly different effects on blood flow to choroid plexus and cerebrum.

  18. Response of Morris-Lecar neurons to various stimuli

    NASA Astrophysics Data System (ADS)

    Wang, Hengtong; Wang, Longfei; Yu, Lianchun; Chen, Yong

    2011-02-01

    We studied the responses of three classes of Morris-Lecar neurons to sinusoidal inputs and synaptic pulselike stimuli with deterministic and random interspike intervals (ISIs). It was found that the responses of the output frequency of class 1 and 2 neurons showed similar evolution properties by varying input amplitudes and frequencies, whereas class 3 neuron exhibited substantially different properties. Specifically, class 1 and 2 neurons display complicated phase locking (p : q, p>q, denoting output action potentials per input spikes) in low-frequency sinusoidal input area when the input amplitude is above their threshold, but a class 3 neuron does not fire action potentials in this area even if the amplitude is much higher. In the case of the deterministic ISI synaptic injection, all the three classes of neurons oscillate spikes with an arbitrary small frequency. When increasing the input frequency (both sinusoidal and deterministic ISI synaptic inputs), all neurons display 1 : 1 phase locking, whereas the response frequency decreases even fall to zero in the high-frequency input area. When the random ISI synaptic pulselike stimuli are injected into the neurons, one can clearly see the low-pass filter behaviors from the return map. The output ISI distribution depends on the mean ISI of input train as well as the ISI variation. Such different responses of three classes of neurons result from their distinct dynamical mechanisms of action potential initiation. It was suggested that the intrinsic dynamical cellular properties are very important to neuron information processing.

  19. Escape and aggregation responses of three echinoderms to conspecific stimuli.

    PubMed

    Campbell, A C; Coppard, S; D'Abreo, C; Tudor-Thomas, R

    2001-10-01

    In marine invertebrates, waterborne chemical stimuli mediate responses including prey detection and predator avoidance. Alarm and flight, in response to damaged conspecifics, have been reported in echinoderms, but the nature of the stimuli involved is not known. The responses of Asterias rubens Linnaeus, Psammechinus miliaris (Gmelin), and Echinus esculentus Linnaeus to conspecifics were tested in a choice chamber against a control of clean seawater (no stimulus). All three species showed statistically significant movement toward water conditioned by whole animals or homogenate of test epithelium. P. miliaris and E. esculentus displayed a statistically significant avoidance reaction, moving away from conspecific coelomic fluid, gut homogenate, and gonad homogenate. A. rubens was indifferent to conspecific coelomic fluid, pyloric cecum homogenate, and gonad homogenate but moved away from cardiac gut homogenate. P. miliaris was indifferent to gametes, but the other two species were significantly attracted to them. No species showed preference for one particular side of the chamber during trials to balance water flow. These echinoderms can distinguish between homogenates of conspecific tissues that might be exposed when a predator damages the test, and those that may emanate from the exterior surface during normal activities. PMID:11687389

  20. Stimuli-responsive nanoparticles for targeting the tumor microenvironment.

    PubMed

    Du, Jinzhi; Lane, Lucas A; Nie, Shuming

    2015-12-10

    One of the most challenging and clinically important goals in nanomedicine is to deliver imaging and therapeutic agents to solid tumors. Here we discuss the recent design and development of stimuli-responsive smart nanoparticles for targeting the common attributes of solid tumors such as their acidic and hypoxic microenvironments. This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment. The nanoparticles are often designed to first "navigate" the body's vascular system, "dock" at the tumor sites, and then "activate" for action inside the tumor interstitial space. They combine the favorable biodistribution and pharmacokinetic properties of nanodelivery vehicles and the rapid diffusion and penetration properties of smaller drug cargos. By targeting the broad tumor habitats rather than tumor-specific receptors, this strategy has the potential to overcome the tumor heterogeneity problem and could be used to design diagnostic and therapeutic nanoparticles for a broad range of solid tumors. PMID:26341694

  1. Chemical force microscopy of stimuli-responsive adhesive copolymers

    NASA Astrophysics Data System (ADS)

    Beaussart, Audrey; Ngo, T. Chinh; Derclaye, Sylvie; Kalinova, Radostina; Mincheva, Rosica; Dubois, Philippe; Leclère, Philippe; Dufrêne, Yves F.

    2013-12-01

    Atomic force microscopy with chemically sensitive tips was used to investigate the hydrophobic and electrostatic interaction forces of a stimuli-responsive adhesive polymer, and their dynamic changes in response to water immersion and salt concentration. Block copolymer-filled coatings were obtained by incorporating an amphiphilic block copolymer containing a polydimethylsiloxane (PDMS) block and a poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) block in a PDMS matrix. Topographic images of fresh samples revealed the presence of nanoscale domains associated with the presence of copolymers, covered by a thin layer of PDMS. Prolonged (30 days) immersion in aqueous solution led to the exposure of the hydrophilic PDMAEMA chains on the surface. Using adhesion force mapping with hydrophobic tips, we showed that fresh samples were uniformly hydrophobic, while aged samples exhibited lower surface hydrophobicity and featured nanoscale hydrophilic copolymer domains. Force mapping with negatively charged tips revealed remarkable salt-dependent force plateau signatures reflecting desorption of polyelectrolyte copolymer chains. These nanoscale experiments show how solvent-induced conformational changes of stimuli-responsive copolymers can be used to modulate surface adhesion.

  2. Organic Nanofibers Embedding Stimuli-Responsive Threaded Molecular Components

    PubMed Central

    2014-01-01

    While most of the studies on molecular machines have been performed in solution, interfacing these supramolecular systems with solid-state nanostructures and materials is very important in view of their utilization in sensing components working by chemical and photonic actuation. Host polymeric materials, and particularly polymer nanofibers, enable the manipulation of the functional molecules constituting molecular machines and provide a way to induce and control the supramolecular organization. Here, we present electrospun nanocomposites embedding a self-assembling rotaxane-type system that is responsive to both optical (UV–vis light) and chemical (acid/base) stimuli. The system includes a molecular axle comprised of a dibenzylammonium recognition site and two azobenzene end groups and a dibenzo[24]crown-8 molecular ring. The dethreading and rethreading of the molecular components in nanofibers induced by exposure to base and acid vapors, as well as the photoisomerization of the azobenzene end groups, occur in a similar manner to what observed in solution. Importantly, however, the nanoscale mechanical function following external chemical stimuli induces a measurable variation of the macroscopic mechanical properties of nanofibers aligned in arrays, whose Young’s modulus is significantly enhanced upon dethreading of the axles from the rings. These composite nanosystems show therefore great potential for application in chemical sensors, photonic actuators, and environmentally responsive materials. PMID:25264943

  3. EEG Responses to Auditory Stimuli for Automatic Affect Recognition.

    PubMed

    Hettich, Dirk T; Bolinger, Elaina; Matuz, Tamara; Birbaumer, Niels; Rosenstiel, Wolfgang; Spüler, Martin

    2016-01-01

    Brain state classification for communication and control has been well established in the area of brain-computer interfaces over the last decades. Recently, the passive and automatic extraction of additional information regarding the psychological state of users from neurophysiological signals has gained increased attention in the interdisciplinary field of affective computing. We investigated how well specific emotional reactions, induced by auditory stimuli, can be detected in EEG recordings. We introduce an auditory emotion induction paradigm based on the International Affective Digitized Sounds 2nd Edition (IADS-2) database also suitable for disabled individuals. Stimuli are grouped in three valence categories: unpleasant, neutral, and pleasant. Significant differences in time domain domain event-related potentials are found in the electroencephalogram (EEG) between unpleasant and neutral, as well as pleasant and neutral conditions over midline electrodes. Time domain data were classified in three binary classification problems using a linear support vector machine (SVM) classifier. We discuss three classification performance measures in the context of affective computing and outline some strategies for conducting and reporting affect classification studies. PMID:27375410

  4. Disruption of postural readaptation by inertial stimuli following space flight

    NASA Technical Reports Server (NTRS)

    Black, F. O.; Paloski, W. H.; Reschke, M. F.; Igarashi, M.; Guedry, F.; Anderson, D. J.

    1999-01-01

    Postural instability (relative to pre-flight) has been observed in all shuttle astronauts studied upon return from orbital missions. Postural stability was more closely examined in four shuttle astronaut subjects before and after an 8 day orbital mission. Results of the pre- and post-flight postural stability studies were compared with a larger (n = 34) study of astronauts returning from shuttle missions of similar duration. Results from both studies indicated that inadequate vestibular feedback was the most significant sensory deficit contributing to the postural instability observed post flight. For two of the four IML-1 astronauts, post-flight postural instability and rate of recovery toward their earth-normal performance matched the performance of the larger sample. However, post-flight postural control in one returning astronaut was substantially below mean performance. This individual, who was within normal limits with respect to postural control before the mission, indicated that recovery to pre-flight postural stability was also interrupted by a post-flight pitch plane rotation test. A similar, though less extreme departure from the mean recovery trajectory was present in another astronaut following the same post-flight rotation test. The pitch plane rotation stimuli included otolith stimuli in the form of both transient tangential and constant centripetal linear acceleration components. We inferred from these findings that adaptation on orbit and re-adaptation on earth involved a change in sensorimotor integration of vestibular signals most likely from the otolith organs.

  5. Response variations to Stroop color-word stimuli.

    PubMed

    Izawa, C; Silver, N C

    1988-05-01

    Reaction times (RTs) and net interference measures were obtained for 64 Stroop color-word stimuli from 8 common colors. Subjects were 64 college students, 32 of each sex. The incongruous stimulus was designated as either the ink interpretation different from the word or the word interpretation different from the ink. Consistently large variations within Stroop stimuli and Word x Ink interactions were found. Complex qualitative and quantitative differences were revealed between sexes. Females had faster RTs, but showed no significant superiority in measured net interference. The derived rank orders of net interference between sexes were correlated when using the ink, but not when using the word. Neither word nor ink were related in ranking RTs. For net interference, however, derived RTs were highly related for women using the ink interpretation, but not when using the word; they were unrelated for men using either interpretation. Two interrference types were highly correlated for women, but not for men. An additional experiment with a color-blind group cast an interesting light on the issue. Our Stroop data, rank ordered by sex for each measure, may assist viable theory constructions, including the context-dependent interaction hypothesis. PMID:3402729

  6. Effects of Olfactory Stimuli on Urge Reduction in Smokers

    PubMed Central

    Sayette, Michael A.; Parrott, Dominic J.

    2013-01-01

    This study examined the possibility that exposure to olfactory stimuli can reduce self-reported urge to smoke. After an initial assessment of self-reported urge, nicotine-deprived smokers evaluated the pleasantness of a series of 8 odors. Facial expressions during odor presentations were coded with P. Ekman and W. V. Friesen’s (1978a) Facial Action Coding System. After odor administration, participants were exposed to smoking cues. Next, participants were administered their most pleasant, least pleasant, or a control odor (water) and reported their urge to smoke. Results indicated that sniffing either a pleasant or unpleasant odor reduced reported urge to smoke relative to the control odor. Reported pleasantness of the odors did not differentially affect urge reduction. Odors eliciting negative-affect-related expressions, however, were less effective than odors that did not elicit negative-affect-related expressions in reducing reported urge. Results of this preliminary investigation provide support for the consideration of odor stimuli as an approach to craving reduction. PMID:10340155

  7. Electrophysiological evidence for automatic processing of erroneous stimuli.

    PubMed

    Mesika, David; Tzur, Gabriel; Berger, Andrea

    2014-07-01

    In a paradigm combining color-word Stroop and misspelled words processing, spelling mistakes were placed in half the Stroop stimuli. Participants were presented with words written in different ink colors and asked to identify the color of the ink while ignoring the word meaning. Importantly, whether the word was correctly spelled or not was completely irrelevant to the task. The spelling manipulation did not change the phonology or semantic meaning of the words. Congruency and spelling correctness were manipulated orthogonally and interacted at the behavioral level. Event-related potentials showed a very early processing of misspelled words. The present findings are in line with the idea of anterior cingulate cortex (ACC) involvement in cognitive monitoring, expressed mainly in the theta frequency band. The present study demonstrates that this monitoring mechanism is elicited automatically, in other words, this mechanism perceives erroneous stimuli even when they are absolutely irrelevant to the participant׳s task. At later processing stages, the same central monitoring mechanism is also involved in the detection/resolution of conflict. PMID:24751991

  8. Empathic behavioral and physiological responses to dynamic stimuli in depression.

    PubMed

    Schneider, Daniel; Regenbogen, Christina; Kellermann, Thilo; Finkelmeyer, Andreas; Kohn, Nils; Derntl, Birgit; Schneider, Frank; Habel, Ute

    2012-12-30

    Major depressive disorder (MDD) is strongly linked to social withdrawal and interpersonal problems which characterize the disorder and further aggravate symptoms. Investigating the nature of impaired emotional-social functioning as a basis of interpersonal functioning in MDD has been widely restricted to static stimuli and behavioral emotion recognition accuracy. The present study aimed at examining higher order emotional processes, namely empathic responses and its components, emotion recognition accuracy and affective responses in 28 MDD patients and 28 healthy control participants. The dynamic stimulus material included 96 short video clips depicting actors expressing basic emotions by face, voice prosody, and sentence content. Galvanic skin conductance measurements revealed implicit processes in the multimethod assessment of empathy. Overall, patients displayed lower empathy, emotion accuracy, and affective response rates than controls. Autonomous arousal was higher in patients. A generalized emotion processing deficit is in line with the "emotional context insensitivity" (ECI) theory which proposes decreased overall responsiveness to emotional stimuli. The dissociation between hypo-reactivity in explicit and hyper-reactivity in implicit measures of emotion processing can be related to the "limbic-cortical dysregulation" model of depression. Our findings support the dissociation of autonomic and subjective emotional responses which may account for interpersonal as well as emotional deficits in depression. PMID:22560057

  9. MEG brain activities reflecting affection for visual food stimuli.

    PubMed

    Kuriki, Shinya; Miyamura, Takahiro; Uchikawa, Yoshinori

    2010-01-01

    This study aimed to explore the modulation of alpha rhythm in response to food pictures with distinct affection values. We examined the method to discriminate subject's state, i.e., whether he/she liked the article of food or not, from MEG signals detected over the head. Pictures of familiar foods were used as affective stimuli, while those pictures with complementary color phase were used as non-affective stimuli. Alpha band signals in a narrow frequency window around the spectral peak of individual subjects were wavelet analyzed and phase-locked component to the stimulus onset was obtained as a complex number. The amplitude of the phase-locked component was averaged during 0-1 s after stimulus onset for 30 epochs in a measurement session and across 76 channels of MEG sensor. In statistical test of individual subjects, significant difference was found in the real part of the averaged phase-locked amplitude between the normal-color and reverse-color pictures. These results suggest that affective information processing of food pictures is reflected in the synchronized component of narrow band alpha rhythm. PMID:21096510

  10. Task Attention Facilitates Learning of Task-Irrelevant Stimuli

    PubMed Central

    Huang, Tsung-Ren; Watanabe, Takeo

    2012-01-01

    Attention plays a fundamental role in visual learning and memory. One highly established principle of visual attention is that the harder a central task is, the more attentional resources are used to perform the task and the smaller amount of attention is allocated to peripheral processing because of limited attention capacity. Here we show that this principle holds true in a dual-task setting but not in a paradigm of task-irrelevant perceptual learning. In Experiment 1, eight participants were asked to identify either bright or dim number targets at the screen center and to remember concurrently presented scene backgrounds. Their recognition performances for scenes paired with dim/hard targets were worse than those for scenes paired with bright/easy targets. In Experiment 2, eight participants were asked to identify either bright or dim letter targets at the screen center while a task-irrelevant coherent motion was concurrently presented in the background. After five days of training on letter identification, participants improved their motion sensitivity to the direction paired with hard/dim targets improved but not to the direction paired with easy/bright targets. Taken together, these results suggest that task-irrelevant stimuli are not subject to the attentional control mechanisms that task-relevant stimuli abide. PMID:22563424

  11. Startle auditory stimuli enhance the performance of fast dynamic contractions.

    PubMed

    Fernandez-Del-Olmo, Miguel; Río-Rodríguez, Dan; Iglesias-Soler, Eliseo; Acero, Rafael M

    2014-01-01

    Fast reaction times and the ability to develop a high rate of force development (RFD) are crucial for sports performance. However, little is known regarding the relationship between these parameters. The aim of this study was to investigate the effects of auditory stimuli of different intensities on the performance of a concentric bench-press exercise. Concentric bench-presses were performed by thirteen trained subjects in response to three different conditions: a visual stimulus (VS); a visual stimulus accompanied by a non-startle auditory stimulus (AS); and a visual stimulus accompanied by a startle auditory stimulus (SS). Peak RFD, peak velocity, onset movement, movement duration and electromyography from pectoralis and tricep muscles were recorded. The SS condition induced an increase in the RFD and peak velocity and a reduction in the movement onset and duration, in comparison with the VS and AS condition. The onset activation of the pectoralis and tricep muscles was shorter for the SS than for the VS and AS conditions. These findings point out to specific enhancement effects of loud auditory stimulation on the rate of force development. This is of relevance since startle stimuli could be used to explore neural adaptations to resistance training. PMID:24489967

  12. Startle Auditory Stimuli Enhance the Performance of Fast Dynamic Contractions

    PubMed Central

    Fernandez-Del-Olmo, Miguel; Río-Rodríguez, Dan; Iglesias-Soler, Eliseo; Acero, Rafael M.

    2014-01-01

    Fast reaction times and the ability to develop a high rate of force development (RFD) are crucial for sports performance. However, little is known regarding the relationship between these parameters. The aim of this study was to investigate the effects of auditory stimuli of different intensities on the performance of a concentric bench-press exercise. Concentric bench-presses were performed by thirteen trained subjects in response to three different conditions: a visual stimulus (VS); a visual stimulus accompanied by a non-startle auditory stimulus (AS); and a visual stimulus accompanied by a startle auditory stimulus (SS). Peak RFD, peak velocity, onset movement, movement duration and electromyography from pectoralis and tricep muscles were recorded. The SS condition induced an increase in the RFD and peak velocity and a reduction in the movement onset and duration, in comparison with the VS and AS condition. The onset activation of the pectoralis and tricep muscles was shorter for the SS than for the VS and AS conditions. These findings point out to specific enhancement effects of loud auditory stimulation on the rate of force development. This is of relevance since startle stimuli could be used to explore neural adaptations to resistance training. PMID:24489967

  13. Nanoparticle role on the repeatability of stimuli-responsive nanocomposites

    PubMed Central

    Ahn, Sungsook; Lee, Sang Joon

    2014-01-01

    Repeatability of the responsiveness with time is one important concern for effective durable functions of stimuli-responsive materials. Although the increase in the yield and tensile strength of the hybrid composite materials by nanoparticle (NP) incorporation has been reported, exact NP effect on stimuli-responsiveness is rarely reported. In this study, a set of nanoscale actuating system is demonstrated by a thermo-sensitive process operated by polyethylene glycol (PEG) linked by gold nanoparticle (AuNP). This designed nanocomposite exclusively provides an artificial on/off gate function for selective passages of permeate molecules. The results demonstrate high repetition efficiency with sharp responding in a timely manner. In terms of the morphology changes induced by repeated swelling-deswelling mechanics, the nanocomposite exhibits phase separation between AuNP clusters and PEG domains. This leads to a delay in responsiveness in a cumulative way with time. Acting as stable junction points in the nanocomposite network structures, the incorporated AuNPs contribute to maintain repeatability in responsiveness. This study contributes to new-concept smart material design and fundamental understanding on the hybrid nanomaterials for various applications in terms of a dynamic mechanical behavior. PMID:25315841

  14. Late Positive Potential ERP Responses to Social and Nonsocial Stimuli in Youth with Autism Spectrum Disorder.

    PubMed

    Benning, Stephen D; Kovac, Megan; Campbell, Alana; Miller, Stephanie; Hanna, Eleanor K; Damiano, Cara R; Sabatino-DiCriscio, Antoinette; Turner-Brown, Lauren; Sasson, Noah J; Aaron, Rachel V; Kinard, Jessica; Dichter, Gabriel S

    2016-09-01

    We examined the late positive potential (LPP) event related potential in response to social and nonsocial stimuli from youths 9 to 19 years old with (n = 35) and without (n = 34) ASD. Social stimuli were faces with positive expressions and nonsocial stimuli were related to common restricted interests in ASD (e.g., electronics, vehicles, etc.). The ASD group demonstrated relatively smaller LPP amplitude to social stimuli and relatively larger LPP amplitude to nonsocial stimuli. There were no group differences in subjective ratings of images, and there were no significant correlations between LPP amplitude and ASD symptom severity within the ASD group. LPP results suggest blunted motivational responses to social stimuli and heightened motivational responses to nonsocial stimuli in youth with ASD. PMID:27344337

  15. An evaluation of the effects of matched stimuli on behaviors maintained by automatic reinforcement.

    PubMed Central

    Piazza, C C; Adelinis, J D; Hanley, G P; Goh, H L; Delia, M D

    2000-01-01

    The purpose of the current investigation was to extend the literature on matched stimuli to three dissimilar forms of aberrant behavior (dangerous climbing and jumping, saliva manipulation, and hand mouthing). The results of functional analyses suggested that each behavior was automatically reinforced. Preference assessments were used to identify two classes of stimuli: items that matched the hypothesized sensory consequences of aberrant behavior (matched stimuli) and items that produced sensory consequences that were not similar to those produced by the aberrant behavior (unmatched stimuli). The effects of providing continuous and noncontingent access to either the most highly preferred matched or the most highly preferred unmatched stimuli were assessed relative to a condition in which no stimuli were available. Overall results suggested that providing access to items that matched the hypothesized sensory consequences of aberrant behavior may be more effective than simply selecting stimuli either arbitrarily or based on the results of preference assessments alone. PMID:10738949

  16. The Motivating Effect of Antecedent Stimuli on the Web Shop: A Conjoint Analysis of the Impact of Antecedent Stimuli at the Point of Online Purchase

    ERIC Educational Resources Information Center

    Fagerstrom, Asle

    2010-01-01

    This article introduces the concept of motivating operation (MO) to the field of online consumer research. A conjoint analysis was conducted to assess the motivating impact of antecedent stimuli on online purchasing. Stimuli tested were in-stock status, price, other customers' reviews, order confirmation procedures, and donation to charity. The…

  17. Perceived Sexual Orientation Based on Vocal and Facial Stimuli Is Linked to Self-Rated Sexual Orientation in Czech Men

    PubMed Central

    Valentova, Jaroslava Varella; Havlíček, Jan

    2013-01-01

    Previous research has shown that lay people can accurately assess male sexual orientation based on limited information, such as face, voice, or behavioral display. Gender-atypical traits are thought to serve as cues to sexual orientation. We investigated the presumed mechanisms of sexual orientation attribution using a standardized set of facial and vocal stimuli of Czech men. Both types of stimuli were rated for sexual orientation and masculinity-femininity by non-student heterosexual women and homosexual men. Our data showed that by evaluating vocal stimuli both women and homosexual men can judge sexual orientation of the target men in agreement with their self-reported sexual orientation. Nevertheless, only homosexual men accurately attributed sexual orientation of the two groups from facial images. Interestingly, facial images of homosexual targets were rated as more masculine than heterosexual targets. This indicates that attributions of sexual orientation are affected by stereotyped association between femininity and male homosexuality; however, reliance on such cues can lead to frequent misjudgments as was the case with the female raters. Although our study is based on a community sample recruited in a non-English speaking country, the results are generally consistent with the previous research and thus corroborate the validity of sexual orientation attributions. PMID:24358180

  18. Detection of Lyβ auto-correlations and Lyα-Lyβ cross-correlations in BOSS Data Release 9

    SciTech Connect

    Iršič, Vid; Slosar, Anže; Sheldon, Erin S. E-mail: anze@bnl.gov; and others

    2013-09-01

    The Lyman-β forest refers to a region in the spectra of distant quasars that lies between the rest-frame Lyman-β and Lyman-γ emissions. The forest in this region is dominated by a combination of absorption due to resonant Lyα and Lyβ scattering. When considering the 1D Lyβ forest in addition to the 1D Lyα forest, the full statistical description of the data requires four 1D power spectra: Lyα and Lyβ auto-power spectra and the Lyα-Lyβ real and imaginary cross-power spectra. We describe how these can be measured using an optimal quadratic estimator that naturally disentangles Lyα and Lyβ contributions. Using a sample of approximately 60,000 quasar sight-lines from the BOSS Data Release 9, we make the measurement of the one-dimensional power spectrum of fluctuations due to the Lyβ resonant scattering. While we have not corrected our measurements for resolution damping of the power and other systematic effects carefully enough to use them for cosmological constraints, we can robustly conclude the following: i) Lyβ power spectrum and Lyα-Lyβ cross spectra are detected with high statistical significance; ii) the cross-correlation coefficient is ≈ 1 on large scales; iii) the Lyβ measurements are contaminated by the associated OVI absorption, which is analogous to the SiIII contamination of the Lyα forest. Measurements of the Lyβ forest will allow extension of the usable path-length for the Lyα measurements while allowing a better understanding of the physics of intergalactic medium and thus more robust cosmological constraints.

  19. Multi-Stimuli-Responsive Polymer Materials: Particles, Films, and Bulk Gels.

    PubMed

    Cao, Zi-Quan; Wang, Guo-Jie

    2016-06-01

    Stimuli-responsive polymers have received tremendous attention from scientists and engineers for several decades due to the wide applications of these smart materials in biotechnology and nanotechnology. Driven by the complex functions of living systems, multi-stimuli-responsive polymer materials have been designed and developed in recent years. Compared with conventional single- or dual-stimuli-based polymer materials, multi-stimuli-responsive polymer materials would be more intriguing since more functions and finer modulations can be achieved through more parameters. This critical review highlights the recent advances in this area and focuses on three types of multi-stimuli-responsive polymer materials, namely, multi-stimuli-responsive particles (micelles, micro/nanogels, vesicles, and hybrid particles), multi-stimuli-responsive films (polymer brushes, layer-by-layer polymer films, and porous membranes), and multi-stimuli-responsive bulk gels (hydrogels, organogels, and metallogels) from recent publications. Various stimuli, such as light, temperature, pH, reduction/oxidation, enzymes, ions, glucose, ultrasound, magnetic fields, mechanical stress, solvent, voltage, and electrochemistry, have been combined to switch the functions of polymers. The polymer design, preparation, and function of multi-stimuli-responsive particles, films, and bulk gels are comprehensively discussed here. PMID:27153184

  20. Impaired Autonomic Responses to Emotional Stimuli in Autoimmune Limbic Encephalitis

    PubMed Central

    Schröder, Olga; Schriewer, Elisabeth; Golombeck, Kristin S.; Kürten, Julia; Lohmann, Hubertus; Schwindt, Wolfram; Wiendl, Heinz; Bruchmann, Maximilian; Melzer, Nico; Straube, Thomas

    2015-01-01

    Limbic encephalitis (LE) is an autoimmune-mediated disorder that affects structures of the limbic system, in particular, the amygdala. The amygdala constitutes a brain area substantial for processing of emotional, especially fear-related signals. The amygdala is also involved in neuroendocrine and autonomic functions, including skin conductance responses (SCRs) to emotionally arousing stimuli. This study investigates behavioral and autonomic responses to discrete emotion evoking and neutral film clips in a patient suffering from LE associated with contactin-associated protein-2 (CASPR2) antibodies as compared to a healthy control group. Results show a lack of SCRs in the patient while watching the film clips, with significant differences compared to healthy controls in the case of fear-inducing videos. There was no comparable impairment in behavioral data (emotion report, valence, and arousal ratings). The results point to a defective modulation of sympathetic responses during emotional stimulation in patients with LE, probably due to impaired functioning of the amygdala. PMID:26648907

  1. Executive control suppresses pupillary responses to aversive stimuli.

    PubMed

    Cohen, Noga; Moyal, Natali; Henik, Avishai

    2015-12-01

    Adaptive behavior depends on the ability to effectively regulate emotional responses. Continuous failure in the regulation of emotions can lead to heightened physiological reactions and to various psychopathologies. Recently, several behavioral and neuroimaging studies showed that exertion of executive control modulates emotion. Executive control is a high-order operation involved in goal-directed behavior, especially in the face of distractors or temptations. However, the role of executive control in regulating emotion-related physiological reactions is unknown. Here we show that exercise of executive control modulates reactivity of both the sympathetic and the parasympathetic components of the autonomic nervous system. Specifically, we demonstrate that both pupillary light reflex and pupil dilation for aversive stimuli are attenuated following recruitment of executive control. These findings offer new insights into the very basic mechanisms of emotion processing and regulation, and can lead to novel interventions for people suffering from emotion dysregulation psychopathologies. PMID:26410694

  2. Massively parallel neural encoding and decoding of visual stimuli.

    PubMed

    Lazar, Aurel A; Zhou, Yiyin

    2012-08-01

    The massively parallel nature of video Time Encoding Machines (TEMs) calls for scalable, massively parallel decoders that are implemented with neural components. The current generation of decoding algorithms is based on computing the pseudo-inverse of a matrix and does not satisfy these requirements. Here we consider video TEMs with an architecture built using Gabor receptive fields and a population of Integrate-and-Fire neurons. We show how to build a scalable architecture for video Time Decoding Machines using recurrent neural networks. Furthermore, we extend our architecture to handle the reconstruction of visual stimuli encoded with massively parallel video TEMs having neurons with random thresholds. Finally, we discuss in detail our algorithms and demonstrate their scalability and performance on a large scale GPU cluster. PMID:22397951

  3. Smart nanocontainers: progress on novel stimuli-responsive polymer vesicles.

    PubMed

    Feng, Anchao; Yuan, Jinying

    2014-04-01

    In the past decade, polymer vesicles prepared by self-assembly techniques have attracted increasing scientific interest based on their unique features highlighted with tunable membrane properties, versatility, stability, and capacity of transporting hydrophilic as well as hydrophobic species. Polymersomes exhibit intriguing potential applications such as cell mimicking dimensions and functions, tunable delivery vehicles, for the templating of biomineralization, nanoreactors, and as scaffolds for biological conjugation. In this Feature Article, an overview of the preparation and application of recently developed "smart" polymer vesicles, which can respond to the novel external stimuli, including carbon dioxide (CO2), electrochemical potential, ultrasound, enzyme, near-infrared light, and magnetic field is given. The response mechanism and morphology change are explored with specific focus on the functionalization of various domains of the polymer vesicles. In addition, the current limitations are explored as well as the challenges facing the development of these nanostructures toward real-world applications. PMID:24522966

  4. Startle modulation before, during and after exposure to emotional stimuli.

    PubMed

    Dichter, Gabriel S; Tomarken, Andrew J; Baucom, Brian R

    2002-02-01

    Although affective modulation of the startle reflex is a highly replicable effect, the majority of studies have administered startle probes during exposure to affective stimuli. To examine more comprehensively the temporal course of startle potentiation, we assessed blink modulation before, during and immediately after exposure to positive, negative and neutral pictures. During each trial, cues about the affective content of pictures were presented, after which acoustic startle probes were delivered either before picture onset, during picture onset or immediately after picture offset. As expected, we observed a linear relation between picture valence and startle amplitude during picture viewing. Surprisingly, startle amplitude was larger while anticipating pleasant and unpleasant pictures relative to neutral pictures. No significant effects were observed during the offset phase. These results indicate that startle modulation is conditional upon temporal factors linked to stimulus onset and offset. PMID:11809522

  5. Stimuli-Responsive Gold Nanoparticles for Cancer Diagnosis and Therapy.

    PubMed

    Tian, Li; Lu, Linfeng; Qiao, Yang; Ravi, Saisree; Salatan, Ferandre; Melancon, Marites P

    2016-01-01

    An emerging concept is that cancers strongly depend on both internal and external signals for growth and invasion. In this review, we will discuss pathological and physical changes in the tumor microenvironment and how these changes can be exploited to design gold nanoparticles for cancer diagnosis and therapy. These intrinsic changes include extracellular and intracellular pH, extracellular matrix enzymes, and glutathione concentration. External stimuli include the application of laser, ultrasound and X-ray. The biology behind these changes and the chemistry behind the responding mechanisms to these changes are reviewed. Examples of recent in vitro and in vivo studies are also presented, and the clinical implications of these findings are discussed. PMID:27455336

  6. Stimuli Responsive Ionogels for Sensing Applications—An Overview

    PubMed Central

    Kavanagh, Andrew; Byrne, Robert; Diamond, Dermot; Fraser, Kevin J.

    2012-01-01

    This overview aims to summarize the existing potential of “Ionogels” as a platform to develop stimuli responsive materials. Ionogels are a class of materials that contain an Ionic Liquid (IL) confined within a polymer matrix. Recently defined as “a solid interconnected network spreading throughout a liquid phase”, the ionogel therefore combines the properties of both its solid and liquid components. ILs are low melting salts that exist as liquids composed entirely of cations and anions at or around 100 °C. Important physical properties of these liquids such as viscosity, density, melting point and conductivity can be altered to suit a purpose by choice of the cation/anion. Here we provide an overview to highlight the literature thus far, detailing the encapsulation of IL and responsive materials within these polymeric structures. Exciting applications in the areas of optical and electrochemical sensing, solid state electrolytes and actuating materials shall be discussed. PMID:24957961

  7. Stimuli-Responsive Peptide-based Triblock and Star Copolymers

    NASA Astrophysics Data System (ADS)

    Ray, Jacob; Naik, Sandeep; Johnson, Ashley; Ly, Jack; Savin, Daniel

    2011-03-01

    Stimuli-responsive copolymers demonstrate diverse aggregation behavior in aqueous solution. In general, the molecular architecture and the balance of hydrophilic and hydrophobic volumes influence morphology. This study involves polypeptide-based ABA linear triblock and AB2 star copolymer (which structurally resemble phospholipids) amphiphiles. Model systems for this study are poly(L-lysine)-b-poly(propylene oxide)-b-poly(L-lysine) (KPK) triblocks and poly(L-glutamate) (PE) based star copolymers. Extensive studies with KPK systems have resulted in morphological transitions by modifying pH, and we hypothesize that a change in individual chain conformation is the driving force for these transitions. Preliminary results for PE-based star copolymers with various hydrophobic moieties suggest polymersome (vesicle) formation. Light scattering (dynamic and static) and TEM were used to determine aggregate size and morphology as a function of pH; furthermore, circular dichroism (CD) spectroscopy was used to measure helix-to-coil transitions of the polypeptide blocks.

  8. Stimuli-responsive polypeptide-based triblock copolymers

    NASA Astrophysics Data System (ADS)

    Ray, Jacob; Naik, Sandeep; Savin, Daniel

    2010-03-01

    Stimuli-responsive copolymers demonstrate diverse aggregation behavior in aqueous solution, where the molecular architecture and hydrophilic/hydrophobic content influences morphology. The solution morphology of poly(lysine)-b-poly(propylene oxide)-b-poly(lysine) (KPK) triblock copolymers with high lysine content (> 75 wt.%) will be compared with complementary KP diblock copolymers in the same phase range. Light scattering and TEM were used to determine aggregate size and morphology as a function of pH and temperature; furthermore, circular dichroism was used to measure helix-to-coil transitions of the K blocks. PK diblocks in this composition range yield spherical micelles over the entire pH range whereas KPK systems appear to exhibit morphological transitions with changing pH.

  9. A ferrocene-based multiple-stimuli responsive organometallogel.

    PubMed

    He, Ting; Li, Kun; Wang, Na; Liao, Ye-Xin; Wang, Xin; Yu, Xiao-Qi

    2014-06-01

    Three new ferrocene-peptide compounds were designed and prepared. We investigated their gelling abilities and found that two of them were capable of gelling various organic solvents, especially alcohols. Gels also formed in mixed alcohol-water solvents, which decreased the critical gelation concentration (CGC) of the gels. Compound 1, comprised of a dipeptide (Phe-Phe) and ferrocene, acted as a novel low-molecular-weight gelator in the formation of metallogel 1 in isopropanol-water (v/v = 1 : 1). This gelation was found to be reversible under redox stimuli; changing of the redox state of ferrocene induced a reversible gel-sol phase transition. Additionally, gel 1 responded to β-CD as a result of host-guest interactions between this compound and ferrocene. With the addition of β-CD, the gel network gradually broke down, as demonstrated by SEM. PMID:24691460

  10. Hybrid biofunctional nanostructures as stimuli-responsive catalytic systems

    PubMed Central

    Marten, Gernot U; Gelbrich, Thorsten

    2010-01-01

    Summary A novel active biocatalytic reaction system is proposed by covalently immobilizing porcine pancreas trypsin within the thermoresponsive polymer shell of superparamagnetic Fe3O4 nanoparticles. Active ester-functional nanocarriers suitable for the immobilization of amino functional targets are obtained in a single polymerization step by grafting-from copolymerization of an active ester monomer from superparamagnetic cores. The comonomer, oligo(ethylene glycol) methyl ether methacrylate, has excellent water solubility at room temperature, biocompatibility, and a tunable lower critical solution temperature (LCST) in water. The phase separation can alternatively be initiated by magnetic heating caused by magnetic losses in ac magnetic fields. The immobilization of porcine pancreas trypsin to the core–shell nanoparticles results in highly active, nanoparticulate biocatalysts that can easily be separated magnetically. The enzymatic activity of the obtained biocatalyst system can be influenced by outer stimuli, such as temperature and external magnetic fields, by utilizing the LCST of the copolymer shell. PMID:20978622

  11. Response of juvenile scalloped hammerhead sharks to electric stimuli.

    PubMed

    Kajiura, Stephen M; Fitzgerald, Timothy P

    2009-01-01

    Sharks can use their electrosensory system to detect electric fields in their environment. Measurements of their electrosensitivity are often derived by calculating the voltage gradient from a model of the charge distribution for an ideal dipole. This study measures the charge distribution around a dipole in seawater and confirms the close correspondence with the model. From this, it is possible to predict how the sharks will respond to dipolar electric fields comprised of differing parameters. We tested these predictions by exposing sharks to different sized dipoles and levels of applied current that simulated the bioelectric fields of their natural prey items. The sharks initiated responses from a significantly greater distance with larger dipole sizes and also from a significantly greater distance with increasing levels of electric current. This study is the first to provide empirical evidence supporting a popular theoretical model and test predictions about how sharks will respond to a variety of different electric stimuli. PMID:19097876

  12. What boxing-related stimuli reveal about response behaviour.

    PubMed

    Ottoboni, Giovanni; Russo, Gabriele; Tessari, Alessia

    2015-01-01

    When two athletes meet inside the ropes of the boxing ring to fight, their cognitive systems have to respond as quickly as possible to a manifold of stimuli to assure victory. In the present work, we studied the pre-attentive mechanisms, which form the basis of an athlete's ability in reacting to an opponent's punches. Expert boxers, beginner boxers and people with no experience of boxing performed a Simon-like task where they judged the colour of the boxing gloves worn by athletes in attack postures by pressing two lateralised keys. Although participants were not instructed to pay attention to the direction of the punches, beginner boxers' responses resembled a defence-related pattern, expert boxers' resembled counterattacks, whereas non-athletes' responses were not influenced by the unrelated task information. Results are discussed in the light of an expertise-related action simulation account. PMID:25385452

  13. Affective response to a set of new musical stimuli.

    PubMed

    Hill, W Trey; Palmer, Jack A

    2010-04-01

    Recently, a novel set of musical stimuli was developed in an attempt to bring more rigor to a paradigm which often falls under scientific scrutiny. Although these musical clips were validated in terms of recognition for emotion, valence, and arousal, the clips were not specifically tested for their ability to elicit certain affective responses. The present study examined self-reported "elation" among 82 participants after listening to one of two types of the musical clips; 47 listened to happy music and 35 listened to sad music. Individuals who listened to happy music reported significantly higher "elation" than individuals who listened to the sad music. These results support the idea that music can elicit certain affective state responses. PMID:20524563

  14. Affective Simon effects using facial expressions as affective stimuli.

    PubMed

    De Houwer, J; Hermans, D; Eelen, P

    1998-01-01

    Two experiments are reported in which facial expressions were presented and participants were asked to respond with the word POSITIVE or NEGATIVE on the basis of a relevant feature of the facial stimuli while ignoring the valence of the expression. Results showed that reaction times were influenced by the match between the valence of the facial expression and the valence of the correct response when the identity of the presented person had to be determined in order to select the correct response, but not when the gender of the presented person was relevant. The present experiments illustrate the flexibility of the affective Simon paradigm and provide a further demonstration of the generalizability of the affective Simon effect. PMID:9677856

  15. Altered processing of sensory stimuli in patients with migraine.

    PubMed

    de Tommaso, Marina; Ambrosini, Anna; Brighina, Filippo; Coppola, Gianluca; Perrotta, Armando; Pierelli, Francesco; Sandrini, Giorgio; Valeriani, Massimiliano; Marinazzo, Daniele; Stramaglia, Sebastiano; Schoenen, Jean

    2014-03-01

    Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes. PMID:24535465

  16. Halftoning method for the generation of motion stimuli

    NASA Technical Reports Server (NTRS)

    Mulligan, Jeffrey B.; Stone, Leland S.

    1989-01-01

    This paper describes a novel computer-graphic technique for the generation of a broad class of motion stimuli for vision research, which uses color table animation in conjunction with a single base image. Using this technique, contrast and temporal frequency can be varied with a negligible amount of computation, once a single-base image is produced. Since only two-bit planes are needed to display a single drifting grating, an eight-bit/pixel display can be used to generate four-component plaids, in which each component of the plaid has independently programmable contrast and temporal frequency. Because the contrast and temporal frequencies of the various components are mutually independent, a large number of two-dimensional stimulus motions can be produced from a single image file.

  17. Brain wave synchronization and entrainment to periodic acoustic stimuli.

    PubMed

    Will, Udo; Berg, Eric

    2007-08-31

    As known, different brainwave frequencies show synchronies related to different perceptual, motor or cognitive states. Brainwaves have also been shown to synchronize with external stimuli with repetition rates of ca. 10-40 Hz. However, not much is known about responses to periodic auditory stimuli with periodicities found in human rhythmic behavior (i.e. 0.5-5 Hz). In an EEG study we compared responses to periodic stimulations (drum sounds and clicks with repetition rates of 1-8 Hz), silence, and random noise. Here we report inter-trial coherence measures taken at the Cz-electrode that show a significant increase in brainwave synchronization following periodic stimulation. Specifically, we found (1) a tonic synchronization response in the delta range with a maximum response at 2 Hz, (2) a phasic response covering the theta range, and (3) an augmented phase synchronization throughout the beta/gamma range (13-44 Hz) produced through increased activity in the lower gamma range and modulated by the stimulus periodicity. Periodic auditory stimulation produces a mixture of evoked and induced, rate-specific and rate-independent increases in stimulus related brainwave synchronization that are likely to affect various cognitive functions. The synchronization responses in the delta range may form part of the neurophysiological processes underlying time coupling between rhythmic sensory input and motor output; the tonic 2 Hz maximum corresponds to the optimal tempo identified in listening, tapping synchronization, and event-interval discrimination experiments. In addition, synchronization effects in the beta and gamma range may contribute to the reported influences of rhythmic entrainment on cognitive functions involved in learning and memory tasks. PMID:17709189

  18. Effects of sequential stimuli on Halobacterium salinarium photobehavior.

    PubMed Central

    Lucia, S; Ferraro, M; Cercignani, G; Petracchi, D

    1996-01-01

    We analyzed the motor photoresponses of Halobacterium salinarium to different test stimuli applied after a first photophobic response produced by a step-down of red-orange light (prestimulus). We observed that pulses given with a suitable delay after the prestimulus produced unusual responses. Pulses of blue, green, or red-orange light, each eliciting no response when applied alone, produced a secondary photophobic response when applied several seconds after the prestimulus; the same occurred with a negative blue pulse (rapid shut-off and turning on of a blue light). Conversely, no secondary photophobic response was observed when the test stimulus was a step (a step-up for red-orange light, a step-down for blue light) of the same wavelength and intensity. When the delay was varied, different results were obtained with different wavelengths; red-orange pulses were typically effective in producing a secondary photophobic response, even with a delay of 2 s, whereas the response to a blue pulse was suppressed when the test stimulus was applied within 5 s after the prestimulus. The secondary photophobic response to pulses was abolished by reducing the intensity of the prestimulus without affecting the primary photophobic response. These results, some of which were previously reported in the literature as inverse effects, must be produced by a facilitating mechanism depending on the prestimulus itself, the occurrence of reversals being per se ineffective. The fact that red-orange test stimuli are facilitated even at the shortest delay, whereas those of different wavelengths become effective only after several seconds, suggests that the putative mechanism of the facilitating effect is specific for different signaling pathways. PMID:8874029

  19. Visual laterality in dolphins: importance of the familiarity of stimuli

    PubMed Central

    2012-01-01

    Background Many studies of cerebral asymmetries in different species lead, on the one hand, to a better understanding of the functions of each cerebral hemisphere and, on the other hand, to develop an evolutionary history of hemispheric laterality. Our animal model is particularly interesting because of its original evolutionary path, i.e. return to aquatic life after a terrestrial phase. The rare reports concerning visual laterality of marine mammals investigated mainly discrimination processes. As dolphins are migrant species they are confronted to a changing environment. Being able to categorize new versus familiar objects would allow dolphins a rapid adaptation to novel environments. Visual laterality could be a prerequisite to this adaptability. To date, no study, to our knowledge, has analyzed the environmental factors that could influence their visual laterality. Results We investigated visual laterality expressed spontaneously at the water surface by a group of five common bottlenose dolphins (Tursiops truncatus) in response to various stimuli. The stimuli presented ranged from very familiar objects (known and manipulated previously) to familiar objects (known but never manipulated) to unfamiliar objects (unknown, never seen previously). At the group level, dolphins used their left eye to observe very familiar objects and their right eye to observe unfamiliar objects. However, eyes are used indifferently to observe familiar objects with intermediate valence. Conclusion Our results suggest different visual cerebral processes based either on the global shape of well-known objects or on local details of unknown objects. Moreover, the manipulation of an object appears necessary for these dolphins to construct a global representation of an object enabling its immediate categorization for subsequent use. Our experimental results pointed out some cognitive capacities of dolphins which might be crucial for their wild life given their fission-fusion social system

  20. Pointing Hand Stimuli Induce Spatial Compatibility Effects and Effector Priming

    PubMed Central

    Nishimura, Akio; Michimata, Chikashi

    2013-01-01

    The present study investigated the automatic influence of perceiving a picture that indicates other’s action on one’s own task performance in terms of spatial compatibility and effector priming. Participants pressed left and right buttons with their left and right hands respectively, depending on the color of a central dot target. Preceding the target, a left or right hand stimulus (pointing either to the left or right with the index or little finger) was presented. In Experiment 1, with brief presentation of the pointing hand, a spatial compatibility effect was observed: responses were faster when the direction of the pointed finger and the response position were spatially congruent than when incongruent. The spatial compatibility effect was larger for the pointing index finger stimulus compared to the pointing little finger stimulus. Experiment 2 employed longer duration of the pointing hand stimuli. In addition to the spatial compatibility effect for the pointing index finger, the effector priming effect was observed: responses were faster when the anatomical left/right identity of the pointing and response hands matched than when the pointing and response hands differed in left/right identity. The results indicate that with sufficient processing time, both spatial/symbolic and anatomical features of a static body part implying another’s action simultaneously influence different aspects of the perceiver’s own action. Hierarchical coding, according to which an anatomical code is used only when a spatial code is unavailable, may not be applicable if stimuli as well as responses contain anatomical features. PMID:23637688

  1. Spectroscopy of supernova host galaxies from the SDSS-II SN survey with the SDSS and BOSS spectrographs

    NASA Astrophysics Data System (ADS)

    Olmstead, Matthew Dwaune

    Type Ia supernovae (SNeIa) have been used as standard candles to measure cosmological distances. The initial discovery of the accelerated expansion of the universe was performed using ~50 SNe Ia. Large SNe surveys have increased the number of spectroscopically-confirmed SNe Ia to over a thousand with redshift coverage beyond z = 1. We are now in the age of abundant photometry without the ability for full follow-up spectroscopy of all SN candidates. SN cosmology using these large samples will increasingly rely on robust photometric classification of SN candidates. Photometric classification will increase the sample by including faint SNe as these are preferentially not observed with follow-up spectroscopy. The primary concern with using photometrically classified SNe Ia in cosmology is when a core-collapse SNe is incorrectly classified as an SN Ia. This can be mitigated by obtaining the host galaxy redshift of each SN candidate and using this information as a prior in the photometric classification, removing one degree of freedom. To test the impact of redshift on photometric classification, I have performed an assessment on photometric classification of candidates from the Sloan Digital Sky Survey-II (SDSS-II) SN Survey. I have tested the classification with and without redshift priors by looking at the change of photometric classification, the effect of data quality on photometric classification, and the effect of SN light curve properties on photometric classification. Following our suggested classification scheme, there are a total of 1038 photometrically classified SNe Ia when using a flat redshift prior and 1002 SNe~Ia with the spectroscopic redshift. For 912 (91.0%) candidates classified as likely SNe Ia without redshift information, the classification is unchanged when adding the host galaxy redshift. Finally, I investigate the differences in the interpretation of the light curve properties with and without knowledge of the redshift. When using the SALT2

  2. A Safe Haven: Investigating Social-Support Figures as Prepared Safety Stimuli.

    PubMed

    Hornstein, Erica A; Fanselow, Michael S; Eisenberger, Naomi I

    2016-08-01

    Although fear-conditioning research has demonstrated that certain survival-threatening stimuli, namely prepared fear stimuli, are readily associated with fearful events, little research has explored whether a parallel category exists for safety stimuli. We examined whether social-support figures, who have typically benefited survival, can serve as prepared safety stimuli, a category that has not been explored previously. Across three experiments, we uncovered three key findings. First, social-support figures were less readily associated with fear than were strangers or neutral stimuli (in a retardation-of-acquisition test). Second, social-support stimuli inhibited conditional fear responses to other cues (in a summation test), and this inhibition continued even after the support stimulus was removed. Finally, these effects were not simply due to familiarity or reward because both familiar and rewarding stimuli were readily associated with fear, whereas social-support stimuli were not. These findings suggest that social-support figures are one category of prepared safety stimuli that may have long-lasting effects on fear-learning processes. PMID:27324266

  3. A Basis for Identifying Stimuli Which Control Behaviors in Natural Settings

    ERIC Educational Resources Information Center

    Patterson, G. R.

    1974-01-01

    Describes procedures for identifying stimuli in the natural environment whose presence was associated with altered probabilities for both the initiation and persistence of noxious responses. (Author/SDH)

  4. Alleged Approach-Avoidance Conflict for Food Stimuli in Binge Eating Disorder

    PubMed Central

    Leehr, Elisabeth J.; Schag, Kathrin; Brinkmann, Amelie; Ehlis, Ann-Christine; Fallgatter, Andreas J.; Zipfel, Stephan; Giel, Katrin E.; Dresler, Thomas

    2016-01-01

    Objective Food stimuli are omnipresent and naturally primary reinforcing stimuli. One explanation for the intake of high amounts of food in binge eating disorder (BED) is a deviant valuation process. Valuation of food stimuli is supposed to influence approach or avoidance behaviour towards food. Focusing on self-reported and indirect (facial electromyography) valuation process, motivational aspects in the processing of food stimuli were investigated. Methods We compared an overweight sample with BED (BED+) with an overweight sample without BED (BED-) and with normal weight controls (NWC) regarding their self-reported and indirect (via facial electromyography) valuation of food versus non-food stimuli. Results Regarding the self-reported valuation, the BED+ sample showed a significantly stronger food-bias compared to the BED- sample, as food stimuli were rated as significantly more positive than the non-food stimuli in the BED+ sample. This self-reported valuation pattern could not be displayed in the indirect valuation. Food stimuli evoked negative indirect valuation in all groups. The BED+ sample showed the plainest approach-avoidance conflict marked by a diverging self-reported (positive) and indirect (negative) valuation of food stimuli. Conclusions BED+ showed a deviant self-reported valuation of food as compared to BED-. The valuation process of the BED+ sample seems to be characterized by a motivational ambivalence. This ambivalence should be subject of further studies and may be of potential use for therapeutic interventions. PMID:27045169

  5. Interpretative bias in spider phobia: Perception and information processing of ambiguous schematic stimuli.

    PubMed

    Haberkamp, Anke; Schmidt, Filipp

    2015-09-01

    This study investigates the interpretative bias in spider phobia with respect to rapid visuomotor processing. We compared perception, evaluation, and visuomotor processing of ambiguous schematic stimuli between spider-fearful and control participants. Stimuli were produced by gradually morphing schematic flowers into spiders. Participants rated these stimuli related to their perceptual appearance and to their feelings of valence, disgust, and arousal. Also, they responded to the same stimuli within a response priming paradigm that measures rapid motor activation. Spider-fearful individuals showed an interpretative bias (i.e., ambiguous stimuli were perceived as more similar to spiders) and rated spider-like stimuli as more unpleasant, disgusting, and arousing. However, we observed no differences between spider-fearful and control participants in priming effects for ambiguous stimuli. For non-ambiguous stimuli, we observed a similar enhancement for phobic pictures as has been reported previously for natural images. We discuss our findings with respect to the visual representation of morphed stimuli and to perceptual learning processes. PMID:26276153

  6. Timing and classifying brief acoustic stimuli by songbirds and humans.

    PubMed

    Weisman, R; Brownlie, L; Olthof, A; Njegovan, M; Sturdy, C; Mewhort, D

    1999-04-01

    The durations of animals' brief vocalizations provide conspecifics with important recognition cues. In the present experiments, zebra finches and humans (trained musicians) were rewarded for responding after S+ (standard) auditory signals from 56 to 663 ms and not for responding after shorter or longer S- (comparison) durations from 10 to 3684 ms. With either a single standard (Experiment 1) or multiple standards (Experiment 2), both zebra finches and humans timed brief signals to about the same level of accuracy. The results were in qualitative agreement with predictions from scalar timing theory and its connectionist implementation in both experiments. The connectionist model provides a good quantitative account of temporal gradients with a single standard (Experiment 1) but not with multiple standards (Experiment 2). PMID:10331915

  7. Preliminary results of the PreViBOSS project: description of the fog life cycle by ground-based and satellite observation

    NASA Astrophysics Data System (ADS)

    Elias, Thierry; Jolivet, Dominique; Dupont, Jean-Charles; Haeffelin, Martial; Burnet, Frédéric

    2012-11-01

    The instrument set-up designed by the PreViBOSS project for the ParisFog field campaign is suitable to sound microphysical properties of droplets and interstitial aerosols during developed fog in a semi-urban environment. Developed fog is defined as LWC < 7 mg m-3 and the temperature vertical gradient over 30 m, ΔT, smaller than 0.04 K/m. Visibility averaged over November 2011 is 385+/-340 m (with rare values larger than 1000 m), and month average of LWC is 60+/-60 mg m-3. The droplet effective radius decreases from 14 to 4 μm when the number concentration increases from less than 10 to 220 cm-3. Particle extinction coefficient is computed by Mie theory applied on size distribution observed during developed fog in ambient conditions by both PALAS WELAS and DMT FM100. Comparison with particle extinction coefficient directly measured by the Degreanne DF20 visibilimeter demonstrates satisfying agreement, within combined uncertainties. Ratio of computed over measured particle extinction coefficient is 1.15+/-0.35. Visibility smaller than 1000 m at 3 m above ground level is observed not only during developed fog but also during shallow fog, which presents a significant vertical gradient, as ΔT > 0.4 K/m. In this case, LWC is highly variable and may be observed below 7 mg m-3. The consequent month average of LWC is 30+/-80 mg m-3. The optical counters miss large droplets significantly contributing to extinction in shallow fogs. Consequently, it is not possible to reproduce with satisfaction the particle extinction coefficient in shallow fog. Fog type may be distinguished by association of groundbased visibilimeter and MSG/SEVIRI. When clear-sky is given by EUMETSAT/NWCSAF cloud type product while visibility is observed smaller than 1000 m at SIRTA, in 75% cases a shallow fog occurs, and in other cases, horizontal heterogeneity characterises the developed fog within the SIRTA pixel, as during the dissipation phase. Moreover, consistently, low and very low clouds are

  8. The Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE) study: cluster randomised trial of humour therapy in nursing homes

    PubMed Central

    Low, Lee-Fay; Brodaty, Henry; Goodenough, Belinda; Spitzer, Peter; Bell, Jean-Paul; Fleming, Richard; Casey, Anne-Nicole; Liu, Zhixin; Chenoweth, Lynn

    2013-01-01

    Objectives To determine whether humour therapy reduces depression (primary outcome), agitation and behavioural disturbances and improves social engagement and quality-of-life in nursing home residents. Design The Sydney Multisite Intervention of LaughterBosses and ElderClowns study was a single-blind cluster randomised controlled trial of humour therapy. Setting 35 Sydney nursing homes. Participants All eligible residents within geographically defined areas within each nursing home were invited to participate. Intervention Professional ‘ElderClowns’ provided 9–12 weekly humour therapy sessions, augmented by resident engagement by trained staff ‘LaughterBosses’. Controls received usual care. Measurements Depression scores on the Cornell Scale for Depression in Dementia, agitation scores on the Cohen-Mansfield Agitation Inventory, behavioural disturbance scores on the Neuropsychiatric Inventory, social engagement scores on the withdrawal subscale of Multidimensional Observation Scale for Elderly Subjects, and self-rated and proxy-rated quality-of-life scores on a health-related quality-of-life tool for dementia, the DEMQOL. All outcomes were measured at the participant level by researchers blind to group assignment. Randomisation Sites were stratified by size and level of care then assigned to group using a random number generator. Results Seventeen nursing homes (189 residents) received the intervention and 18 homes (209 residents) received usual care. Groups did not differ significantly over time on the primary outcome of depression, or on behavioural disturbances other than agitation, social engagement and quality of life. The secondary outcome of agitation was significantly reduced in the intervention group compared with controls over 26 weeks (time by group interaction adjusted for covariates: p=0.011). The mean difference in change from baseline to 26 weeks in Blom-transformed agitation scores after adjustment for covariates was 0.17 (95% CI 0

  9. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: BAO measurement from the LOS-dependent power spectrum of DR12 BOSS galaxies

    NASA Astrophysics Data System (ADS)

    Gil-Marín, Héctor; Percival, Will J.; Cuesta, Antonio J.; Brownstein, Joel R.; Chuang, Chia-Hsun; Ho, Shirley; Kitaura, Francisco-Shu; Maraston, Claudia; Prada, Francisco; Rodríguez-Torres, Sergio; Ross, Ashley J.; Schlegel, David J.; Schneider, Donald P.; Thomas, Daniel; Tinker, Jeremy L.; Tojeiro, Rita; Vargas Magaña, Mariana; Zhao, Gong-Bo

    2016-08-01

    [abridged] We present an anisotropic analysis of the baryonic acoustic oscillation (BAO) scale in the twelfth and final data release of the Baryonic Oscillation Spectroscopic Survey (BOSS). We independently analyse the LOWZ and CMASS galaxy samples: the LOWZ sample contains contains 361 762 galaxies with an effective redshift of $z_{\\rm LOWZ}=0.32$; the CMASS sample consists of 777 202 galaxies with an effective redshift of $z_{\\rm CMASS}=0.57$. We extract the BAO peak position from the monopole power spectrum moment, $\\alpha_0$, and from the $\\mu^2$ moment, $\\alpha_2$, where $\\mu$ is the cosine of the angle to the line-of-sight. The $\\mu^2$-moment provides equivalent information to that available in the quadrupole but is simpler to analyse. After applying a reconstruction algorithm to reduce the BAO suppression by bulk motions, we measure the BAO peak position in the monopole and $\\mu^2$-moment, which are related to radial and angular shifts in scale. We report $H(z_{\\rm LOWZ})r_s(z_d)=(11.60\\pm0.60)\\cdot10^3 {\\rm km}s^{-1}$ and $D_A(z_{\\rm LOWZ})/r_s(z_d)=6.66\\pm0.16$ with a cross-correlation coefficient of $r_{HD_A}=0.41$, for the LOWZ sample; and $H(z_{\\rm CMASS})r_s(z_d)=(14.56\\pm0.37)\\cdot10^3 {\\rm km}s^{-1}$ and $D_A(z_{\\rm CMASS})/r_s(z_d)=9.42\\pm0.13$ with a cross-correlation coefficient of $r_{HD_A}=0.47$, for the CMASS sample. We combine these results with the measurements of the BAO peak position in the monopole and quadrupole correlation function of the same dataset \\citep[][companion paper]{Cuestaetal2015} and report the consensus values: $H(z_{\\rm LOWZ})r_s(z_d)=(11.63\\pm0.69)\\cdot10^3 {\\rm km}s^{-1}$ and $D_A(z_{\\rm LOWZ})/r_s(z_d)=6.67\\pm0.15$ with $r_{HD_A}=0.35$ for the LOWZ sample; $H(z_{\\rm CMASS})r_s(z_d)=(14.67\\pm0.42)\\cdot10^3 {\\rm km}s^{-1}$ and $D_A(z_{\\rm CMASS})/r_s(z_d)=9.47\\pm0.12$ with $r_{HD_A}=0.52$ for the CMASS sample.

  10. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: BAO measurement from the LOS-dependent power spectrum of DR12 BOSS galaxies

    NASA Astrophysics Data System (ADS)

    Gil-Marín, Héctor; Percival, Will J.; Cuesta, Antonio J.; Brownstein, Joel R.; Chuang, Chia-Hsun; Ho, Shirley; Kitaura, Francisco-Shu; Maraston, Claudia; Prada, Francisco; Rodríguez-Torres, Sergio; Ross, Ashley J.; Schlegel, David J.; Schneider, Donald P.; Thomas, Daniel; Tinker, Jeremy L.; Tojeiro, Rita; Vargas Magaña, Mariana; Zhao, Gong-Bo

    2016-08-01

    We present an anisotropic analysis of the baryon acoustic oscillation (BAO) scale in the twelfth and final data release of the Baryon Oscillation Spectroscopic Survey (BOSS). We independently analyse the LOWZ and CMASS galaxy samples: the LOWZ sample contains 361 762 galaxies with an effective redshift of zLOWZ = 0.32; the CMASS sample consists of 777 202 galaxies with an effective redshift of zCMASS = 0.57. We extract the BAO peak position from the monopole power-spectrum moment, α0, and from the μ2 moment, α2, where μ is the cosine of the angle to the line of sight. The μ2-moment provides equivalent information to that available in the quadrupole but is simpler to analyse. After applying a reconstruction algorithm to reduce the BAO suppression by bulk motions, we measure the BAO peak position in the monopole and μ2-moment, which are related to radial and angular shifts in scale. We report H(zLOWZ)rs(zd) = (11.60 ± 0.60) × 103 km s-1 and DA(zLOWZ)/rs(zd) = 6.66 ± 0.16 with a cross-correlation coefficient of r_{HD_A}=0.41, for the LOWZ sample; and H(zCMASS)rs(zd) = (14.56 ± 0.37) × 103 km s-1 and DA(zCMASS)/rs(zd) = 9.42 ± 0.13 with a cross-correlation coefficient of r_{HD_A}=0.47, for the CMASS sample. We demonstrate that our results are not affected by the fiducial cosmology assumed for the analysis. We combine these results with the measurements of the BAO peak position in the monopole and quadrupole correlation function of the same data set (Cuesta et al. 2016, companion paper) and report the consensus values: H(zLOWZ)rs(zd) = (11.63 ± 0.69) × 103 km s-1 and DA(zLOWZ)/rs(zd) = 6.67 ± 0.15 with r_{HD_A}=0.35 for the LOWZ sample; H(zCMASS)rs(zd) = (14.67 ± 0.42) × 103 km s-1 and DA(zCMASS)/rs(zd) = 9.47 ± 0.12 with r_{HD_A}=0.52 for the CMASS sample.

  11. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: BAO measurement from the LOS-dependent power spectrum of DR12 BOSS galaxies

    NASA Astrophysics Data System (ADS)

    Gil-Marín, Héctor; Percival, Will J.; Cuesta, Antonio J.; Brownstein, Joel R.; Chuang, Chia-Hsun; Ho, Shirley; Shu Kitaura, Francisco-; Maraston, Claudia; Prada, Francisco; Rodríguez-Torres, Sergio; Ross, Ashley J.; Schlegel, David J.; Schneider, Donald P.; Thomas, Daniel; Tinker, Jeremy L.; Tojeiro, Rita; Vargas Magaña, Mariana; Zhao, Gong-Bo

    2016-05-01

    We present an anisotropic analysis of the baryonic acoustic oscillation (BAO) scale in the twelfth and final data release of the Baryonic Oscillation Spectroscopic Survey (BOSS). We independently analyse the LOWZ and CMASS galaxy samples: the LOWZ sample contains contains 361 762 galaxies with an effective redshift of zLOWZ = 0.32; the CMASS sample consists of 777 202 galaxies with an effective redshift of zCMASS = 0.57. We extract the BAO peak position from the monopole power spectrum moment, α0, and from the μ2 moment, α2, where μ is the cosine of the angle to the line-of-sight. The μ2-moment provides equivalent information to that available in the quadrupole but is simpler to analyse. After applying a reconstruction algorithm to reduce the BAO suppression by bulk motions, we measure the BAO peak position in the monopole and μ2-moment, which are related to radial and angular shifts in scale. We report H(zLOWZ)rs(zd) = (11.60 ± 0.60) · 103 kms-1 and DA(zLOWZ)/rs(zd) = 6.66 ± 0.16 with a cross-correlation coefficient of r_{HD_A}=0.41, for the LOWZ sample; and H(zCMASS)rs(zd) = (14.56 ± 0.37) · 103 kms-1 and DA(zCMASS)/rs(zd) = 9.42 ± 0.13 with a cross-correlation coefficient of r_{HD_A}=0.47, for the CMASS sample. We demonstrate that our results are not affected by the fiducial cosmology assumed for the analysis. We combine these results with the measurements of the BAO peak position in the monopole and quadrupole correlation function of the same dataset (Cuesta et al. 2016, companion paper) and report the consensus values: H(zLOWZ)rs(zd) = (11.63 ± 0.69) · 103 kms-1 and DA(zLOWZ)/rs(zd) = 6.67 ± 0.15 with r_{HD_A}=0.35 for the LOWZ sample; H(zCMASS)rs(zd) = (14.67 ± 0.42) · 103 kms-1 and DA(zCMASS)/rs(zd) = 9.47 ± 0.12 with r_{HD_A}=0.52 for the CMASS sample.

  12. The Spatial Standard Observer

    NASA Technical Reports Server (NTRS)

    Watson, Andrew B.; Ahumada, Albert J, Jr.

    2006-01-01

    The spatial standard observer is a computational model that provides a measure of the visibility of a target in a uniform background image or of the visual discriminability of two images. Standard observers have long been used in science and industry to quantify the discriminability of colors. Color standard observers address the spectral characteristics of visual stimuli, while the spatial standard observer (SSO), as its name indicates, addresses spatial characteristics. The SSO is based on a model of human vision. The SSO was developed in a process that included evaluation of a number of earlier mathematical models that address optical, physiological, and psychophysical aspects of spatial characteristics of human visual perception. Elements of the prior models are incorporated into the SSO, which is formulated as a compromise between accuracy and simplicity. The SSO operates on a digitized monochrome still image or on a pair of such images. The SSO consists of three submodels that operate sequentially on the input image(s): 1. A contrast model, which converts an input monochrome image to a luminance contrast image, wherein luminance values are expressed as excursions from, and normalized to, a mean; 2. A contrast-sensitivity-filter model that includes an oblique-effect filter (which accounts for the decline in contrast sensitivity at oblique viewing angles); and 3. A spatial summation model, in which responses are spatially pooled by raising each pixel to the power beta, adding the results, and raising the sum to the 1/b power. In this model, b=2.9 was found to be a suitable value. The net effect of the SSO is to compute a numerical measure of the perceptual strength of the single image, or of the visible difference (denoted the perceptual distance) between two images. The unit of a measure used in the SSO is the just noticeable difference (JND), which is a standard measure of perceptual discriminability. A target that is just visible has a measure of 1 JND.

  13. Investigating Mixture Interactions of Astringent Stimuli Using the Isobole Approach.

    PubMed

    Fleming, Erin E; Ziegler, Gregory R; Hayes, John E

    2016-09-01

    Astringents (alum, malic acid, tannic acid) representing 3 broad classes (multivalent salts, organic acids, and polyphenols) were characterized alone, and as 2- and 3-component mixtures using isoboles. In experiment 1, participants rated 7 attributes ("astringency," the sub-qualities "drying," "roughing," and "puckering," and the side tastes "bitterness," "sourness," and "sweetness") using direct scaling. Quality specific power functions were calculated for each stimulus. In experiment 2, the same participants characterized 2- and 3-component mixtures. Multiple factor analysis (MFA) and hierarchical clustering on attribute ratings across stimuli indicate "astringency" is highly related to "bitterness" as well as "puckering," and the subqualities "drying" and "roughing" are somewhat redundant. Moreover, power functions were used to calculate indices of interaction (I) for each attribute/mixture combination. For "astringency," there was evidence of antagonism, regardless of the type of mixture. Conversely, for subqualities, the pattern of interaction depended on the mixture type. Alum/tannic acid and tannic acid/malic acid mixtures showed evidence of synergy for "drying" and "roughing"; alum/malic acid mixtures showed evidence of antagonism for "drying," "roughing," and "puckering." Collectively, these data clarify some semantic ambiguity regarding astringency and its subqualities, as well as the nature of interactions of among different types of astringents. Present data are not inconsistent with the idea that astringency arises from multiple mechanisms, although it remains to be determined whether the synergy observed here might reflect simultaneous activation of these multiple mechanisms. PMID:27252355

  14. Child and adult vibrotactile thresholds for sinusoidal and pulsatile stimuli.

    PubMed

    Bernstein, L E; Schechter, M B; Goldstein, M H

    1986-07-01

    Three experiments were performed to obtain vibrotactile sensitivity thresholds from hearing children and adults, and from deaf children. An adaptive two-interval forced-choice procedure was used to obtain estimates of the 70.7% point on the psychometric sensitivity curve. When hearing children of 5-6 and 9-10 years of age and adults were tested with sinusoids and haversine pulse stimuli, at 10, 100, 160, and 250 Hz or pps, respectively, only the 10-Hz stimulus resulted in an age effect. For this stimulus, young children were significantly less sensitive than adults. When sinusoids were again tested at 20, 40, 80, and 160 Hz, a small overall effect of age was observed with a significant effect only at 20 Hz. Two prelingually profoundly deaf children were tested with haversine pulse trains at 10, 50, 100, 160, and 250 pps. Both children were at least as sensitive to the tactile stimulation as were the hearing children and adults. Pulsatile stimulation, compared to sinusoidal stimulation, exhibited relatively flat threshold versus frequency functions. The present results, demonstrating no age effect for pulsatile stimulation and similar performance for deaf and hearing children, suggest that pulsatile stimulation would be appropriate in vibrotactile speech communication aids for the deaf. PMID:3745657

  15. Irrelevance of sample stimuli and directed forgetting in pigeons

    PubMed Central

    Grant, Douglas S.; Barnet, Robert C.

    1991-01-01

    A successive matching procedure was used to investigate which aspect of the test-omission procedure is responsible for establishing a postsample stimulus as a cue to forget in pigeons. It was found that a postsample stimulus that reliably followed a sample that was irrelevant to performance functioned as a cue to forget. This result was obtained regardless of whether termination of that postsample stimulus was followed by reinforcement or by the presentation of sample-independent discriminative stimuli. It was also found that a postsample stimulus that functioned as a cue to forget at the beginning of training lost that function when it was repeatedly presented on trials in which the sample was relevant to performance. These findings reveal that (a) neither a reduction in reinforcement rate nor the omission of the opportunity for discriminated responding is necessary to establish an effective cue to forget and (b) irrelevance of the sample to performance is a sufficient condition to establish a cue to forget. These results suggest that a postsample stimulus that is presented on trials in which remembering the sample is not reinforced differentially will come to set the occasion for not remembering the sample. PMID:16812631

  16. Stimuli of pepsinogen secretion from frog isolated peptic cells

    SciTech Connect

    Matsumoto, H.; Komiyama, K.; Shirakawa, T.; Heldman, A.; Anderson, W.; Hirschowitz, B.I.

    1986-03-05

    The authors have previously studied pepsinogen (Pg) secretion from isolated intact esophageal mucosa of the bullfrog R. catesbeiana. By stimulus-response studies using agonists and antagonists they characterized specific stimulation of cholinergic, adrenergic and peptidergic receptors and interaction of cAMP and Ca/sup 2 +/ dependent pathways. To understand cell mechanisms more definitively and to relate these to morphology it was necessary to isolate peptic cells. Esophageal mucosa was digested with 0.1% collagenase for 80-100 min and sieved through teflon mesh. One esophagus yielded approximately 10/sup 7/ cells, 70% pure and 89 +/- 5% viable. Basal secretion was 3% of Pg content/hr. The cells responded to graded concentrations of bombesin, bethanechol, IBMX, 8Br-cAMP, forskolin, TPA (12-0-tetradecanoyl phorbol 13 acetate) and A23187. The response to (TPA + A23187) was double the additive single output values; (TPA + A23187 + forskolin) stimulated secretion of more than double the sum of the 3 component stimuli. In calcium and magnesium-free medium, the A23187 response and the synergistic response of combinations were both lost. They have identified 3 messengers for Pg cell stimulation - cAMP, Ca/sup 2 +/ mobilization and protein kinase C - each of which can be separately stimulated, and when combined are strongly synergistic.

  17. Stimuli-responsive gels as reaction vessels and reusable catalysts.

    PubMed

    Díaz Díaz, David; Kühbeck, Dennis; Koopmans, Rudy J

    2011-01-01

    As part of a continuing scientific challenge, a substantial effort during the past few decades has been devoted towards altering the selectivity of chemical transformations by arranging the potential reactants in a number of organized and confining media. Such systems, having features significantly different from those of isotropic solutions, include, for example, micelles, microemulsions, molecular aggregates, liquid crystals, and zeolites. Among these materials, stimuli-response gels constitute another important class of nanostructured and dynamic systems with high active surface areas and remarkable diffusion properties. Within this group, polymer gels have been traditionally used to obtain catalytic and reactive soft materials. Moreover, gels made of low-molecular-weight compounds represent a major novelty in this area as potential soft-vessels to carry out chemical reactions with control on product selectivity. In addition, the possibility of integrating switchable catalytic functions in both organo- and hydrogels shall accelerate the development of robust platforms for the 'bottom-up' tailor-fabrication of more sophisticated functional materials. The present critical review reports on the most important results published during the last decade regarding the use of 'smart' gels that has displayed promising properties as selective soft-nanoreactors and/or heterogeneous recyclable catalysts (152 references). PMID:20877874

  18. Capture of attention to threatening stimuli without perceptual awareness

    PubMed Central

    Lin, Jeffrey Y.; Murray, Scott O.; Boynton, Geoffrey M.

    2009-01-01

    Summary Visual images that convey threatening information can automatically capture attention [1-4]. One example is an object looming in the direction of the observer—presumably because such a stimulus signals an impending collision [5]. A critical question for understanding the relationship between attention and conscious awareness is whether awareness is required for this type of prioritized attentional selection [6]. Although it has been suggested that visual spatial attention can only be affected by consciously perceived events [7], we show that automatic allocation of attention can occur even without conscious awareness of impending threat. We used a visual search task to show that a looming stimulus on a collision path with an observer captures attention but a looming stimulus on a near-miss path does not. Critically, observers were unaware of any difference between collision and near-miss stimuli even when explicitly asked to discriminate between them in separate experiments. These results counter traditional salience-based models of attentional capture, demonstrating that in the absence of perceptual awareness, the visual system can extract behaviorally relevant details from a visual scene and automatically categorize threatening versus non-threatening images at a level of precision beyond our conscious perceptual capabilities. PMID:19523828

  19. Attentional Bias toward Suicide-Related Stimuli Predicts Suicidal Behavior

    PubMed Central

    Cha, Christine B.; Najmi, Sadia; Park, Jennifer M.; Finn, Christine T.; Nock, Matthew K.

    2010-01-01

    A long-standing challenge for scientific and clinical work on suicidal behavior is that people often are motivated to deny or conceal suicidal thoughts. We proposed that people considering suicide would possess an objectively measurable attentional bias toward suicide-related stimuli, and that this bias would predict future suicidal behavior. Participants were 124 adults presenting to a psychiatric emergency department who were administered a modified emotional Stroop task and followed for six months. Suicide attempters showed an attentional bias toward suicide-related words relative to neutral words, and this bias was strongest among those who had made a more recent attempt. Importantly, this suicide-specific attentional bias predicted which people made a suicide attempt over the next six months, above and beyond other clinical predictors. Attentional bias toward more general negatively-valenced words did not predict any suicide-related outcomes, supporting the specificity of the observed effect. These results suggest that suicide-specific attentional bias can serve as a behavioral marker for suicidal risk, and ultimately improve scientific and clinical work on suicide-related outcomes. PMID:20677851

  20. The Neural Response to Maternal Stimuli: An ERP Study

    PubMed Central

    Wu, Lili; Gu, Ruolei; Cai, Huajian; Luo, Yu L. L.; Zhang, Jianxin

    2014-01-01

    Mothers are important to all humans. Research has established that maternal information affects individuals' cognition, emotion, and behavior. We measured event-related potentials (ERPs) to examine attentional and evaluative processing of maternal stimuli while participants completed a Go/No-go Association Task that paired mother or others words with good or bad evaluative words. Behavioral data showed that participants responded faster to mother words paired with good than the mother words paired with bad but showed no difference in response to these others across conditions, reflecting a positive evaluation of mother. ERPs showed larger P200 and N200 in response to mother than in response to others, suggesting that mother attracted more attention than others. In the subsequent time window, mother in the mother + bad condition elicited a later and larger late positive potential (LPP) than it did in the mother + good condition, but this was not true for others, also suggesting a positive evaluation of mother. These results suggest that people differentiate mother from others during initial attentional stage, and evaluative mother positively during later stage. PMID:25375157

  1. Peculiarities of hearing impairment depending on interaction with acoustic stimuli

    PubMed Central

    Myshchenko, Iryna; Nazarenko, Vasyl; Kolganov, Anatoliy; Tereshchenko, Pavlo

    2015-01-01

    Aims: The functional state of the auditory analyzer of several operators groups was study. The objective of this study was to determine some characteristics of hearing impairment in relation with features of acoustic stimuli and informative significance of noise. Materials and Methods: 236 employees (middle age 35.4 ± 0.74 years) were divided into four groups according to features of noise perception at the workplaces. The levels of permanent shifts of acoustic thresholds were estimated using audiometric method. Statistical Analysis Used: Common statistical methods were used in research. Mean quantity and mean absolute errors were calculated. Statistical significance between operators' groups was calculated with 0.05 confidential intervals. Results: The peculiarities of hearing impairment in observed groups were different. Operators differentiating acoustic signals had peak of hearing impairment in the field of language frequencies, while the employees who work with noise background at the workplaces had maximal hearing threshold on the 4000 Hz frequency (P ≤ 0.05). Conclusions: Hearing impairment depends both on energy and human interaction with acoustic irritant. The distinctions in hearing impairment may be related with the necessity of recognizing of acoustic signals and their frequency characteristics. PMID:26957812

  2. Brief Emotion Regulation Training Facilitates Arousal Control During Sexual Stimuli.

    PubMed

    van Overveld, Mark; Borg, Charmaine

    2015-01-01

    Disgust, a negative emotion which evokes strong behavioral avoidance tendencies, has been associated with sexual dysfunction. Recently, it was postulated that healthy sexual functioning requires a balance between excitatory (increased sexual arousal) and inhibitory processes (lowered disgust levels). This suggests that amplification of excitatory processes (like sexual arousal) could be a valuable addition to treatments for affect-based sexual dysfunctions. The major aim of the present study was to establish whether up-regulation could effectively enhance arousal levels during sexual stimuli, and whether such a training would simultaneously reduce disgust. Students (N = 163, mean age = 20.73 years, SD = 2.35) were trained in up-regulation of affect using either a sexual arousal film (i.e., female-friendly erotic movie) or a threat arousal film clip (i.e., horror movie), while control groups viewed the films without training instructions. Following this, participants viewed and rated state emotions during a series of pictures (sexual, disgusting, or neutral). Up-regulation of mood successfully enhanced general arousal in both groups, yet these arousal levels were not paralleled by reductions in disgust. Overall, the findings indicate that emotion regulation training by maximizing positive affect and general arousal could be an effective instrument to facilitate affect-related disturbances in sexual dysfunctions. PMID:25258109

  3. Retrospective Attention Gates Discrete Conscious Access to Past Sensory Stimuli

    PubMed Central

    Thibault, Louis; van den Berg, Ronald; Cavanagh, Patrick; Sergent, Claire

    2016-01-01

    Cueing attention after the disappearance of visual stimuli biases which items will be remembered best. This observation has historically been attributed to the influence of attention on memory as opposed to subjective visual experience. We recently challenged this view by showing that cueing attention after the stimulus can improve the perception of a single Gabor patch at threshold levels of contrast. Here, we test whether this retro-perception actually increases the frequency of consciously perceiving the stimulus, or simply allows for a more precise recall of its features. We used retro-cues in an orientation-matching task and performed mixture-model analysis to independently estimate the proportion of guesses and the precision of non-guess responses. We find that the improvements in performance conferred by retrospective attention are overwhelmingly determined by a reduction in the proportion of guesses, providing strong evidence that attracting attention to the target’s location after its disappearance increases the likelihood of perceiving it consciously. PMID:26863625

  4. Macular Preprocessing of Linear Acceleratory Stimuli: Implications for the Clinic

    NASA Technical Reports Server (NTRS)

    Ross, M. D.; Hargens, Alan R. (Technical Monitor)

    1996-01-01

    Three-dimensional reconstructions of innervation patterns in rat maculae were carried out using serial section images sent to a Silicon Graphics workstation from a transmission electron microscope. Contours were extracted from mosaicked sections, then registered and visualized using Biocomputation Center software. Purposes were to determine innervation patterns of type II cells and areas encompassed by vestibular afferent receptive fields. Terminals on type II cells typically are elongated and compartmentalized into parts varying in vesicular content; reciprocal and serial synapses are common. The terminals originate as processes of nearby calyces or from nerve fibers passing to calyces outside the immediate vicinity. Thus, receptive fields of the afferents overlap in unique ways. Multiple processes are frequent; from 4 to 6 afferents supply 12-16 terminals on a type II cell. Processes commonly communicate with two type II cells. The morphology indicates that extensive preprocessing of linear acceleratory stimuli occurs peripherally, as is true also of visual and olfactory systems. Clinically, this means that loss of individual nerve fibers may not be noticed behaviorally, due to redundancy (receptive field overlap). However, peripheral processing implies the presence of neuroactive agents whose loss can acutely or chronically alter normal peripheral function and cause balance disorders. (Platform presentation preferred - Theme 11)

  5. Neural markers of a greater female responsiveness to social stimuli

    PubMed Central

    Proverbio, Alice M; Zani, Alberto; Adorni, Roberta

    2008-01-01

    Background There is fMRI evidence that women are neurally predisposed to process infant laughter and crying. Other findings show that women might be more empathic and sensitive than men to emotional facial expressions. However, no gender difference in the brain responses to persons and unanimated scenes has hitherto been demonstrated. Results Twenty-four men and women viewed 220 images portraying persons or landscapes and ERPs were recorded from 128 sites. In women, but not in men, the N2 component (210–270) was much larger to persons than to scenes. swLORETA showed significant bilateral activation of FG (BA19/37) in both genders when viewing persons as opposed to scenes. Only women showed a source of activity in the STG and in the right MOG (extra-striate body area, EBA), and only men in the left parahippocampal area (PPA). Conclusion A significant gender difference was found in activation of the left and right STG (BA22) and the cingulate cortex for the subtractive condition women minus men, thus indicating that women might have a greater preference or interest for social stimuli (faces and persons). PMID:18590546

  6. Astrocytes Release Polyunsaturated Fatty Acids by Lipopolysaccharide Stimuli.

    PubMed

    Aizawa, Fuka; Nishinaka, Takashi; Yamashita, Takuya; Nakamoto, Kazuo; Koyama, Yutaka; Kasuya, Fumiyo; Tokuyama, Shogo

    2016-01-01

    We previously reported that levels of long-chain fatty acids (FAs) including docosahexaenoic acids (DHA) increase in the hypothalamus of inflammatory pain model mice. However, the precise mechanisms underlying the increment of free fatty acids (FFAs) in the brain during inflammation remains unknown. In this study, we characterized FFAs released by inflammatory stimulation in rat primary cultured astrocytes, and tested the involvement of phospholipase A2 (PLA2) on these mechanisms. Lipopolysaccharide (LPS) stimulation significantly increased the levels of several FAs in the astrocytes. Under these conditions, mRNA expression of cytosolic PLA2 (cPLA2) and calcium-independent PLA2 (iPLA2) in LPS-treated group increased compared with the control group. Furthermore, in the culture media, the levels of DHA and arachidonic acid (ARA) significantly increased by LPS stimuli compared with those of a vehicle-treated control group whereas the levels of saturated FAs (SFAs), namely palmitic acid (PAM) and stearic acid (STA), did not change. In summary, our findings suggest that astrocytes specifically release DHA and ARA by inflammatory conditions. Therefore astrocytes might function as a regulatory factor of DHA and ARA in the brain. PMID:27374285

  7. Memory for emotional stimuli in patients with Alzheimer's disease.

    PubMed

    Fleming, Kirsten; Kim, Susan H; Doo, Michael; Maguire, Gerald; Potkin, Steven G

    2003-01-01

    Although a hallmark of Alzheimer's disease (AD) is memory impairment, there is speculation that recall may be enhanced when an emotional component is associated with an event. The current study aims to assess whether patients with AD would recall emotionally laden material better than neutral stimuli. DSM-IV-diagnosed AD patients with mild to moderate dementia, as well as groups of young and elderly healthy controls, participated in this study. All subjects were administered three word lists for three trials each. The words were positive, negative, or neutral in valence and matched for concreteness, emotionality, and pleasantness. As expected, the controls performed significantly better than the AD patients. Importantly, the pattern of recall for the emotions was different, such that both control groups recalled all emotions equally, whereas the AD patients recalled significantly more negative words than positive or neutral. These findings of improved immediate memory for emotional material in AD lends support to the notion that mnemonic functions are differentially affected in the disease. PMID:14682081

  8. Auditory Sensory Substitution is Intuitive and Automatic with Texture Stimuli

    PubMed Central

    Stiles, Noelle R. B.; Shimojo, Shinsuke

    2015-01-01

    Millions of people are blind worldwide. Sensory substitution (SS) devices (e.g., vOICe) can assist the blind by encoding a video stream into a sound pattern, recruiting visual brain areas for auditory analysis via crossmodal interactions and plasticity. SS devices often require extensive training to attain limited functionality. In contrast to conventional attention-intensive SS training that starts with visual primitives (e.g., geometrical shapes), we argue that sensory substitution can be engaged efficiently by using stimuli (such as textures) associated with intrinsic crossmodal mappings. Crossmodal mappings link images with sounds and tactile patterns. We show that intuitive SS sounds can be matched to the correct images by naive sighted participants just as well as by intensively-trained participants. This result indicates that existing crossmodal interactions and amodal sensory cortical processing may be as important in the interpretation of patterns by SS as crossmodal plasticity (e.g., the strengthening of existing connections or the formation of new ones), especially at the earlier stages of SS usage. An SS training procedure based on crossmodal mappings could both considerably improve participant performance and shorten training times, thereby enabling SS devices to significantly expand blind capabilities. PMID:26490260

  9. The several roles of stimuli in token reinforcement.

    PubMed

    Bullock, Christopher E; Hackenberg, Timothy D

    2015-03-01

    Three experiments were conducted with pigeons to identify the stimulus functions of tokens in second-order token-reinforcement schedules. All experiments employed two-component multiple schedules with a token-reinforcement schedule in one component and a schedule with equivalent response requirements and/or reinforcer density in the other. In Experiment 1, response rates were lower under a token-reinforcement schedule than under a tandem schedule with the same response requirements, suggesting a discriminative role for the tokens. In Experiment 2, response rates varied systematically with signaling functions of the tokens in a series of conditions designed to explore other aspects of the temporal-correlative relations between tokens and food. In Experiment 3, response rates were reduced but not eliminated by presenting tokens independent of responding, yoked to their temporal occurrence in a preceding token component, suggesting both a reinforcing function and eliciting/evocative functions based on stimulus-food relations. Only when tokens were removed entirely was responding eliminated. On the whole, the results suggest that tokens, as stimuli temporally correlated with food, may serve multiple stimulus functions in token-reinforcement procedures--reinforcing, discriminative, or eliciting--depending on the precise arrangement of the contingencies in which they are embedded. PMID:25604188

  10. Microenvironmental stimuli for proliferation of functional islet β-cells

    PubMed Central

    2014-01-01

    Diabetes is characterized by high blood glucose level due to either autoimmune destruction of islet β-cells or insufficient insulin secretion or glucose non-responsive production of insulin by β-cells. It is highly desired to replace biological functional β-cells for the treatment of diabetes. Unfortunately, β-cells proliferate with an extremely low rate. This cellular property hinders cell-based therapy for clinical application. Many attempts have been made to develop techniques that allow production of large quantities of clinically relevant islet β-cells in vitro. A line of studies evidently demonstrate that β-cells can proliferate under certain circumstances, giving the hopes for generating and expanding these cells in vitro and transplanting them to the recipient. In this review, we discuss the requirements of microenvironmental stimuli that stimulate β-cell proliferation in cell cultures. We highlight advanced approaches for augmentation of β-cell expansion that have recently emerged in this field. Furthermore, knowing the signaling pathways and molecular mechanisms would enable manipulating cell proliferation and optimizing its insulin secretory function. Thus, signaling pathways involved in the enhancement of cell proliferation are discussed as well. PMID:24594290

  11. Interhemispheric transfer and the processing of foveally presented stimuli.

    PubMed

    Brysbaert, M

    1994-10-20

    Two arguments are commonly given in favor of a nasotemporal overlap along the vertical meridian of the visual field: anatomical findings and the existence of macular sparing in hemianopia. A review of the literature, however, points to the weakness of the evidence. The anatomical indications are exclusively based on horseradish peroxidase studies, which can not give an unequivocal answer to the amount of overlap in central vision, and which were not supported by a recent study that made use of the more direct [14C]2-deoxy-D-glucose technique. The argument of macular sparing in hemianopia appears to be derived evidence that depends on the validity of the anatomical findings. In addition, behavioral studies consistently failed to find functional confirmation of the overlap. To further test the possibility of bilateral representation in central vision, a new paradigm is proposed. It is argued that if interhemispheric transfer is needed for the processing of foveally presented stimuli, the word-beginning superiority effect should be larger for subjects with left hemisphere dominance than for subjects with right hemisphere dominance. Results are in line with the hypothesis and point to the fact that interhemispheric transfer of visual information may be involved in more processing than usually accepted. It is also noted that transfer time seems to depend on the amount of information that must be transferred, and is significantly shorter than the estimates obtained in visual half field studies. PMID:7840882

  12. Ethnic Differences in Physiological Responses to Fear Conditioned Stimuli

    PubMed Central

    Martínez, Karen G.; Franco-Chaves, José A.; Milad, Mohammed R.; Quirk, Gregory J.

    2014-01-01

    The idea that emotional expression varies with ethnicity is based largely on questionnaires and behavioral observations rather than physiological measures. We therefore compared the skin conductance responses (SCR) of Hispanic (Puerto Rican) and White non-Hispanic subjects in a fear conditioning and fear extinction task. Subjects were recruited from two sites: San Juan, Puerto Rico (PR), and Boston, Massachusetts (MA), using identical methods. A total of 78 healthy subjects (39 from PR, 39 from MA) were divided by sex and matched for age and educational level. Females from the two sites did not differ in their SCRs during any experimental phase of fear conditioning (habituation, conditioning, or extinction). In contrast, PR males responded significantly to the conditioned stimulus than MA males or PR females. Subtracting ethnic differences observed during the habituation phase (prior to conditioning) eliminated differences from subsequent phases, suggesting that PR males are elevated in their response to novelty rather than fear learning. Our findings suggest that, in addition to sex differences, there are ethnic differences in physiological responses to novel stimuli at least in males, which could be relevant for the assessment and treatment of anxiety disorders. PMID:25501365

  13. Ethnic differences in physiological responses to fear conditioned stimuli.

    PubMed

    Martínez, Karen G; Franco-Chaves, José A; Milad, Mohammed R; Quirk, Gregory J

    2014-01-01

    The idea that emotional expression varies with ethnicity is based largely on questionnaires and behavioral observations rather than physiological measures. We therefore compared the skin conductance responses (SCR) of Hispanic (Puerto Rican) and White non-Hispanic subjects in a fear conditioning and fear extinction task. Subjects were recruited from two sites: San Juan, Puerto Rico (PR), and Boston, Massachusetts (MA), using identical methods. A total of 78 healthy subjects (39 from PR, 39 from MA) were divided by sex and matched for age and educational level. Females from the two sites did not differ in their SCRs during any experimental phase of fear conditioning (habituation, conditioning, or extinction). In contrast, PR males responded significantly to the conditioned stimulus than MA males or PR females. Subtracting ethnic differences observed during the habituation phase (prior to conditioning) eliminated differences from subsequent phases, suggesting that PR males are elevated in their response to novelty rather than fear learning. Our findings suggest that, in addition to sex differences, there are ethnic differences in physiological responses to novel stimuli at least in males, which could be relevant for the assessment and treatment of anxiety disorders. PMID:25501365

  14. Neural Correlates of the Perception of Spoiled Food Stimuli

    PubMed Central

    Becker, Christoph A.; Flaisch, Tobias; Renner, Britta; Schupp, Harald T.

    2016-01-01

    The elicitation of disgust by the view of spoiled and rotten foods is considered as an adaptation preventing the ingestion of harmful microorganisms and pathogens. To provide an effective behavioral defense, inedible food items need to be detected automatically, i.e., in the absence of explicit processing goals, early in the processing stream, and triggering an alarm response, i.e., increased attentional capture. To examine these hypotheses, a set of stimulus material consisting of images of perishable foods (i.e., dairies, meats, fruits, and vegetables) at various stages of natural decay ranging from appetitive to disgusting was developed. In separate sessions, functional imaging and dense sensor event related potential (ERP) data were collected while participants (N = 24) viewed the stimulus materials. Functional imaging data indicated larger activations in the extrastriate visual cortex during the processing of inedible as compared to edible food items. Furthermore, ERP recordings indicated that the processing of inedible food stimuli was associated with a relative positivity over inferior occipital sensor sites already at early stages of processing (<200 ms), and subsequently, an increased late positive potential (LPP) over parieto-occipital sensor regions. Taken together, these findings demonstrate the brain’s sensitivity to visual cues of foods that are spoiled or rotten. PMID:27445746

  15. Hangover hyperthermia in rats: relation to tolerance and external stimuli.

    PubMed

    Sinclair, J D; Taira, T

    1988-01-01

    The recent finding of rebound hyperthermia in rats on the day after a single IP injection or oral intubation of ethanol was confirmed. In our studies, body temperature measured by rectal probe was significantly decreased for 8 h after 2.5 g/kg ethanol IP and was then significantly elevated 16-24 h after injection; increased vocalization during handling at 24 h was also found. However, rats isolated in a sound-attenuation chamber with remote temperature measurement showed no hyperthermia even though they were hypothermic during intoxication. The results do not support the hypothesis that rebound hyperthermia was caused by either a disruption of circadian rhythms, or by a mild abstinence syndrome alone. Instead, it appears that external stimuli, perhaps related to stress or associated with ethanol administration, are necessary on the day after a moderate dose of ethanol to produce the hyperthermia. Like hangover in humans, hyperthermia was reduced in rats made tolerant to ethanol: both the hypothermia and the rebound hyperthermia were significantly lower on the day after the 12th alternate-day ethanol injection than after the first injection. The aftereffects in rats of acute intoxication are, by definition, hangover signs, and they resemble hangover in humans in several ways, but their relevance as an animal model of hangover remains to be determined. PMID:3127841

  16. The Interfering Effect of Distracting Stimuli on the Infant's Memory

    ERIC Educational Resources Information Center

    McCall, Robert B.; And Others

    1977-01-01

    Infants 3 1/2 months of age were assessed for the possible role of the dissimilarity of the distracting stimulus to the originally learned standard in a modified familiarization-distraction-test paradigm. (Author/JMB)

  17. Political diversity versus stimuli diversity: Alternative ways to improve social psychological science.

    PubMed

    Kessler, Thomas; Proch, Jutta; Hechler, Stefanie; Nägler, Larissa A

    2015-01-01

    Instead of enhancing diversity in research groups, we suggest that in order to reduce biases in social psychological research a more basic formulation and systematic testing of theories is required. Following the important but often neglected ecological research approach would lead to systematic variation of stimuli and sometimes representative sampling of stimuli for specific environments. PMID:26786753

  18. Time and Number Discrimination in a Bisection Task with a Sequence of Stimuli: A Developmental Approach.

    ERIC Educational Resources Information Center

    Droit-Volet, Sylvie; Clement, Angelique; Fayol, Michel

    2003-01-01

    This study tested 5- and 8-year-olds and adults in a bisection task with a sequence of stimuli in which time and number co-varied. Findings indicated that the number of stimuli interfered with 5-year-olds' performance on the temporal bisection task. Number interference decreased both with age and counting strategy. In the numerical bisection task,…

  19. Functional Hemispheric Differences for the Categorization of Global and Local Information in Naturalistic Stimuli

    ERIC Educational Resources Information Center

    Hubner, Ronald; Studer, Tobias

    2009-01-01

    Up to now functional hemispheric asymmetries for global/local processing have mainly been investigated with hierarchical letters as stimuli. In the present study, three experiments were conducted to examine whether corresponding visual-field (VF) effects can also be obtained with more naturalistic stimuli. To this end, images of animals with a…

  20. Rescuing Stimuli from Invisibility: Inducing a Momentary Release from Visual Masking with Pre-Target Entrainment

    ERIC Educational Resources Information Center

    Mathewson, Kyle E.; Fabiani, Monica; Gratton, Gabriele; Beck, Diane M.; Lleras, Alejandro

    2010-01-01

    At near-threshold levels of stimulation, identical stimulus parameters can result in very different phenomenal experiences. Can we manipulate which stimuli reach consciousness? Here we show that consciousness of otherwise masked stimuli can be experimentally induced by sensory entrainment. We preceded a backward-masked stimulus with a series of…

  1. Attentional and affective processing of sexual stimuli in women with hypoactive sexual desire disorder.

    PubMed

    Brauer, Marieke; van Leeuwen, Matthijs; Janssen, Erick; Newhouse, Sarah K; Heiman, Julia R; Laan, Ellen

    2012-08-01

    Hypoactive sexual desire disorder (HSDD) is the most common sexual problem in women. From an incentive motivation perspective, HSDD may be the result of a weak association between sexual stimuli and rewarding experiences. As a consequence, these stimuli may either lose or fail to acquire a positive meaning, resulting in a limited number of incentives that have the capacity to elicit a sexual response. According to current information processing models of sexual arousal, sexual stimuli automatically activate meanings and if these are not predominantly positive, processes relevant to the activation of sexual arousal and desire may be interrupted. Premenopausal U.S. and Dutch women with acquired HSDD (n = 42) and a control group of sexually functional women (n = 42) completed a single target Implicit Association Task and a Picture Association Task assessing automatic affective associations with sexual stimuli and a dot detection task measuring attentional capture by sexual stimuli. Results showed that women with acquired HSDD displayed less positive (but not more negative) automatic associations with sexual stimuli than sexually functional women. The same pattern was found for self-reported affective sex-related associations. Participants were slower to detect targets in the dot detection task that replaced sexual images, irrespective of sexual function status. As such, the findings point to the relevance of affective processing of sexual stimuli in women with HSDD, and imply that the treatment of HSDD might benefit from a stronger emphasis on the strengthening of the association between sexual stimuli and positive meaning and sexual reward. PMID:21892693

  2. The Development of Attention to Simple and Complex Visual Stimuli in Infants: Behavioral and Psychophysiological Measures

    ERIC Educational Resources Information Center

    Richards, John E.

    2010-01-01

    The study of visual attention in infants has used presentation of single simple stimuli, multi-dimensional stimuli, and complex dynamic video presentations. There are both continuities and discontinuities in the findings on attention and attentiveness to stimulus complexity. A continuity is a pattern of looking that is found in the early part of…

  3. Exploring the Development and Dismantling of Equivalence Classes Involving Terrorist Stimuli

    ERIC Educational Resources Information Center

    Dixon, Mark R.; Rehfeldt, Ruth Anne; Zlomke, Kimberly R.; Robinson, Ashton

    2006-01-01

    The present paper describes 2 studies that present a conceptual interpretation and experimental findings involving the developing and dismantling of equivalence classes consisting of terrorist stimuli. In the first study, 8 United States citizen participants were trained to match nonterrorist stimuli to American and terrorist images. Afterwards,…

  4. Perceptual interactions in the loudness of combined auditory and vibrotactile stimuli

    PubMed Central

    Wilson, E. Courtenay; Braida, Louis D.; Reed, Charlotte M.

    2010-01-01

    The loudness of auditory (A), tactile (T), and auditory-tactile (A+T) stimuli was measured at supra-threshold levels. Auditory stimuli were pure tones presented binaurally through headphones; tactile stimuli were sinusoids delivered through a single-channel vibrator to the left middle fingertip. All stimuli were presented together with a broadband auditory noise. The A and T stimuli were presented at levels that were matched in loudness to that of the 200-Hz auditory tone at 25 dB sensation level. The 200-Hz auditory tone was then matched in loudness to various combinations of auditory and tactile stimuli (A+T), and purely auditory stimuli (A+A). The results indicate that the matched intensity of the 200-Hz auditory tone is less when the A+T and A+A stimuli are close together in frequency than when they are separated by an octave or more. This suggests that A+T integration may operate in a manner similar to that found in auditory critical band studies, further supporting a strong frequency relationship between the auditory and somatosensory systems. PMID:21117753

  5. Conceptualizing Media Stimuli in Experimental Research: Psychological versus Attribute-Based Definitions

    ERIC Educational Resources Information Center

    Tao, Chen-Chao; Bucy, Erik P.

    2007-01-01

    This paper argues for a clearer conceptualization of media stimuli in experimental research and identifies 3 issues impeding our understanding of message processing: (a) assumptions bolstered by manipulation checks about homogeneity of response to media stimuli, (b) conflation of 2 different classes of variables--media attributes and psychological…

  6. Sex differences in the subjective and reinforcing effects of visual and olfactory cigarette smoke stimuli.

    PubMed

    Perkins, K A; Gerlach, D; Vender, J; Grobe, J; Meeker, J; Hutchison, S

    2001-05-01

    Although nicotine intake clearly reinforces cigarette smoking behavior, non-nicotine smoke stimuli may become conditioned reinforcers of smoking. In Study 1, we compared the acute subjective and reinforcing effects of cigarette smoking in men and women under two conditions: blockade of visual and olfactory/taste smoke stimuli vs. no blockade. Subjective hedonic ratings of 'like puffs' and 'satisfying', but not 'strength', 'high in nicotine', or CO boost, were significantly reduced under the blockade vs. no blockade conditions. During subsequent ad lib puffing, significantly fewer puffs were self-administered under the blockade condition, particularly among women. In Study 2, we examined the influences of these stimuli separately and found that olfactory/taste stimuli, but not visual stimuli, reduced hedonic ratings and puff self-administration in women but not in men. In Study 3, procedures similar to those in Study 1 were used to examine whether this sex difference in responses to conditioned stimuli generalizes to a non-drug consummatory behavior, eating (pizza). However, hedonic ratings and ad lib consumption of pizza were substantially reduced in both men and women following blockade of visual and olfactory/taste food stimuli. These results indicate that the presumably conditioned stimuli of olfactory/taste from cigarette smoke may influence subjective hedonic ratings and reinforcement from smoking more in women than in men. However, this sex difference may not generalize beyond smoking or other drug reinforcement. PMID:11403728

  7. Emotion Recognition in Animated Compared to Human Stimuli in Adolescents with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Brosnan, Mark; Johnson, Hilary; Grawmeyer, Beate; Chapman, Emma; Benton, Laura

    2015-01-01

    There is equivocal evidence as to whether there is a deficit in recognising emotional expressions in Autism spectrum disorder (ASD). This study compared emotion recognition in ASD in three types of emotion expression media (still image, dynamic image, auditory) across human stimuli (e.g. photo of a human face) and animated stimuli (e.g. cartoon…

  8. Resistance to Change and Frequency of Response-Dependent Stimuli Uncorrelated with Reinforcement

    ERIC Educational Resources Information Center

    Podlesnik, Christopher A.; Jimenez-Gomez, Corina; Ward, Ryan D.; Shahan, Timothy A.

    2009-01-01

    Stimuli uncorrelated with reinforcement have been shown to enhance response rates and resistance to disruption; however, the effects of different rates of stimulus presentations have not been assessed. In two experiments, we assessed the effects of adding different rates of response-dependent brief stimuli uncorrelated with primary reinforcement…

  9. A direct comparison of the taste of electrical and chemical stimuli.

    PubMed

    Stevens, David A; Baker, Diane; Cutroni, Elizabeth; Frey, Alexander; Pugh, David; Lawless, Harry T

    2008-06-01

    Three multidimensional scaling studies were conducted to compare the taste qualities evoked from electrical and chemical stimulation, including ferrous sulfate as a typical "metallic" taste stimulus. Bipolar, anodal, and cathodal stimulation were delivered by 1.5- or 3-V batteries applied to the tongue. Solutions of chemical stimuli including prototypical tastes and binary mixtures were evaporated on small metal disks to provide tactile impressions similar to those of the battery stimuli and avoid any potential response biases induced by the subjects' knowledge of the form of the stimulus. Multidimensional unfolding was performed to place stimuli and verbal descriptors in common perceptual spaces. Bipolar, anodal, and cathodal stimuli were tested in separate experiments but generated very similar perceptual spaces and were differentiated from the chemical stimuli. Electrical stimuli were associated with descriptors, such as metallic, copper penny, and iron nail, regardless of the polarity of stimulation. Taste qualities evoked by electric stimuli may not be fully described by commonly used taste stimuli or their binary mixtures and appear most adequately described by a unique metallic taste. PMID:18316314

  10. Trained and Derived Relations with Pictures versus Abstract Stimuli as Nodes

    ERIC Educational Resources Information Center

    Arntzen, Erik; Lian, Torunn

    2010-01-01

    Earlier studies have shown divergent results concerning the use of familiar picture stimuli in demonstration of equivalence. In the current experiment, we trained 16 children to form three 3-member classes in a many-to-one training structure. Half of the participants were exposed first to a condition with all abstract stimuli and then to a…

  11. Pupillary Reactivity to Emotional Stimuli in Children of Depressed and Anxious Mothers

    ERIC Educational Resources Information Center

    Burkhouse, Katie L.; Siegle, Greg J.; Gibb, Brandon E.

    2014-01-01

    Background: The primary aim of this study was to examine differences in physiological reactivity (measured via pupillometry) to emotional stimuli between children of depressed versus nondepressed mothers. A second goal was to examine differences in pupil dilation to emotional stimuli between children of anxious versus nonanxious mothers. Method:…

  12. Matching- and Nonmatching-to-Sample Concept Learning in Rats Using Olfactory Stimuli

    ERIC Educational Resources Information Center

    April, L. Brooke; Bruce, Katherine; Galizio, Mark

    2011-01-01

    Previous research has shown that rats can learn matching-to-sample relations with olfactory stimuli; however, the specific characteristics of this relational control are unclear. In Experiment 1, 6 rats were trained to either match or nonmatch to sample in a modified operant chamber using common household spices as olfactory stimuli. After…

  13. Control by Contextual Stimuli in Novel Second-Order Conditional Discriminations

    ERIC Educational Resources Information Center

    Perez-Gonzalez, Luis Antonio; Martinez, Hector

    2007-01-01

    Eighteen undergraduates participated in studies designed to examine the factors that produce transfer of contextual functions to novel stimuli in second-order conditional discriminations. In Study 1, participants selected comparison B1 given sample A1 and comparison B2 given sample A2 in a matching-to-sample procedure. Contextual stimuli X1 or X2…

  14. The Effects on Visually Impaired Children of Viewing Fluorescent Stimuli under Black-Light Conditions.

    ERIC Educational Resources Information Center

    LaGrow, S. J.; Leung, J-P.; Leung, S.; Yeung, P.

    1998-01-01

    This study compared effects of four visual conditions of stimuli and light on the visual performance of 30 children with low vision (divided into high, and low, visual-acuity groups). Orange stimuli viewed under black light resulted in the best overall performance, benefitted the low-acuity group more than the high-acuity group, and was the…

  15. The Formation of Implicit and Explicit Attitudes for Neutral and Valenced Stimuli Using the Self

    ERIC Educational Resources Information Center

    Perugini, Marco; Richetin, Juliette; Zogmaister, Cristina

    2012-01-01

    In Evaluative Conditioning (EC) studies, novel Conditioned Stimuli (CSs) are usually selected so to be neutral. However, in real life, because of the tendency of humans to evaluate novel stimuli automatically, novel CSs are very often initially valenced. From the literature little is known on whether EC can be successful under these conditions. In…

  16. Can Infants' Orientation to Social Stimuli Predict Later Joint Attention Skills?

    ERIC Educational Resources Information Center

    Schietecatte, Inge; Roeyers, Herbert; Warreyn, Petra

    2012-01-01

    From the moment infants are born, they seem to prefer orienting to social stimuli, over objects and non-social stimuli. This preference lasts throughout adulthood and is believed to play a crucial role in social-communicative development. By following up a group of infants at the age of 6, 8, and 12 months, this study explored the role of social…

  17. Natural stimuli improve auditory BCIs with respect to ergonomics and performance

    NASA Astrophysics Data System (ADS)

    Höhne, Johannes; Krenzlin, Konrad; Dähne, Sven; Tangermann, Michael

    2012-08-01

    Moving from well-controlled, brisk artificial stimuli to natural and less-controlled stimuli seems counter-intuitive for event-related potential (ERP) studies. As natural stimuli typically contain a richer internal structure, they might introduce higher levels of variance and jitter in the ERP responses. Both characteristics are unfavorable for a good single-trial classification of ERPs in the context of a multi-class brain-computer interface (BCI) system, where the class-discriminant information between target stimuli and non-target stimuli must be maximized. For the application in an auditory BCI system, however, the transition from simple artificial tones to natural syllables can be useful despite the variance introduced. In the presented study, healthy users (N = 9) participated in an offline auditory nine-class BCI experiment with artificial and natural stimuli. It is shown that the use of syllables as natural stimuli does not only improve the users’ ergonomic ratings; also the classification performance is increased. Moreover, natural stimuli obtain a better balance in multi-class decisions, such that the number of systematic confusions between the nine classes is reduced. Hopefully, our findings may contribute to make auditory BCI paradigms more user friendly and applicable for patients.

  18. Responses to moving small-field stimuli by the praying mantis, Sphodromantis lineola (Burmeister)

    PubMed

    Prete, F R; McLean, T; McMillin, P J

    1996-01-01

    Adult, female praying mantises, Sphodromantis lineola (Burmeister), were presented with mechanically driven or computer generated stimuli in a series of seven experiments in order to test several hypotheses regarding visual prey recognition. When presented with a series of square black and white computer generated stimuli against a white background, mantises performed the highest rates of predatory behavior in response to those stimuli with a greater proportion of black versus white pixels (i.e., those that produced larger luminance decrements). Higher response rates to computer generated stimuli that produced larger luminance decrements were also seen when the stimuli were irregularly shaped or consisted of two small synchronized stimuli. Mantises responded characteristically to mechanically driven stimuli that were camouflaged to match the background against which they moved, preferring small (vs. large) squares and rectangles that were elongated parallel (vs. perpendicular) to their direction of movement. Finally, response rate to a small, preferred mechanically presented or computer generated stimulus was suppressed by a concurrent large-field stimulus in inverse proportion to the distance between the two stimuli. This phenomenon is characteristic of systems that include phasic lateral inhibitory circuits. All of these results are consistent with the existence of a movement detector visual sub-system, as found in other orthopteromorph insects such as acridid grasshoppers and cockroaches. PMID:8834784

  19. Amygdala neural activity reflects spatial attention towards stimuli promising reward or threatening punishment

    PubMed Central

    Peck, Christopher J; Salzman, C Daniel

    2014-01-01

    Humans and other animals routinely identify and attend to sensory stimuli so as to rapidly acquire rewards or avoid aversive experiences. Emotional arousal, a process mediated by the amygdala, can enhance attention to stimuli in a non-spatial manner. However, amygdala neural activity was recently shown to encode spatial information about reward-predictive stimuli, and to correlate with spatial attention allocation. If representing the motivational significance of sensory stimuli within a spatial framework reflects a general principle of amygdala function, then spatially selective neural responses should also be elicited by sensory stimuli threatening aversive events. Recordings from amygdala neurons were therefore obtained while monkeys directed spatial attention towards stimuli promising reward or threatening punishment. Neural responses encoded spatial information similarly for stimuli associated with both valences of reinforcement, and responses reflected spatial attention allocation. The amygdala therefore may act to enhance spatial attention to sensory stimuli associated with rewarding or aversive experiences. DOI: http://dx.doi.org/10.7554/eLife.04478.001 PMID:25358090

  20. Electrophysiological evidence that drug cues have greater salience than other affective stimuli in opiate addiction.

    PubMed

    Lubman, D I; Allen, N B; Peters, L A; Deakin, J F W

    2008-11-01

    Previous research has demonstrated that drug cues are able to capture attentional resources in addicted populations. However, few studies have controlled for the possibility that drug users find all motivationally significant (i.e., affective) stimuli particularly salient. We examined this issue in opiate addiction, by exploring the impact of drug-related and affective stimuli on central attentional processes. Sixteen male heroin addicts (seven on opiate pharmacotherapy and nine recently detoxified subjects) and 12 matched controls were studied. Subjects were fitted with a 32-channel electrode cap and were instructed to passively view a series of neutral, affective and opiate-related images. The P300 elicited by drug-related stimuli was significantly larger than that elicited by affective and neutral stimuli in opiate users but not controls. Baseline ratings of craving were also found to predict the degree of P300 facilitation to the drug-related stimuli in the addicted group. Further, the opiate group demonstrated an absence of the typical enhancement of ERP responses to non-drug affective stimuli. These results suggest that opiate addicts demonstrate greater cortical processing of drug cues than other types of affective stimuli. Further research is required to assess whether addiction is specifically associated with reduced sensitivity to natural rewards, aversive stimuli or affective cues in general. PMID:18208907

  1. Brief Report: Inhibitory Control of Socially Relevant Stimuli in Children with High Functioning Autism

    ERIC Educational Resources Information Center

    Geurts, Hilde M.; Begeer, Sander; Stockmann, Lex

    2009-01-01

    The current study explored whether inhibitory control deficits in high functioning autism (HFA) emerged when socially relevant stimuli were used and whether arousal level affected the performance. A Go/NoGo paradigm, with socially relevant stimuli and varying presentation rates, was applied in 18 children with HFA (including children with autism…

  2. Effects of Social Stimuli on Laughing and Smiling in Young Children with Angelman Syndrome

    ERIC Educational Resources Information Center

    Richman, David M.; Gernat, Eric; Teichman, Heather

    2006-01-01

    The effects of social stimuli present and absent on laughing and smiling in 2 young children with Angelman syndrome were assessed via a multielement design. Results indicated that laughing and smiling for either child was unaffected by the social stimuli assessed in the social interaction condition. Results are discussed in terms of the effects of…

  3. Integration of semicircular canal and otolith information for multisensory orientation stimuli

    NASA Technical Reports Server (NTRS)

    Ormsby, C. C.; Young, L. R.

    1977-01-01

    This paper presents a model for the perception of dynamic orientation resulting from stimuli which involve both the otoliths and the semicircular canals. The model was applied to several multisensory stimuli and its predictions evaluated. In all cases, the model predictions were in substantial agreement with the known illusions or with the relevant experimental data.

  4. International Standards.

    ERIC Educational Resources Information Center

    Havard-Williams, Peter

    1982-01-01

    Discussion of standardization on an international scale for resource sharing--cooperation, coordination, interlibrary loans, cooperative acquisition and cataloging--focuses on a definition of standards; the development of standards for cataloging; public, school, and university libraries; and library education. A 60-item bibliography is included.…

  5. Agnosia for mirror stimuli: a new case report with a small parietal lesion.

    PubMed

    Martinaud, Olivier; Mirlink, Nicolas; Bioux, Sandrine; Bliaux, Evangéline; Lebas, Axel; Gerardin, Emmanuel; Hannequin, Didier

    2014-11-01

    Only seven cases of agnosia for mirror stimuli have been reported, always with an extensive lesion. We report a new case of an agnosia for mirror stimuli due to a circumscribed lesion. An extensive battery of neuropsychological tests and a new experimental procedure to assess visual object mirror and orientation discrimination were assessed 10 days after the onset of clinical symptoms, and 5 years later. The performances of our patient were compared with those of four healthy control subjects matched for age. This test revealed an agnosia for mirror stimuli. Brain imaging showed a small right occipitoparietal hematoma, encompassing the extrastriate cortex adjoining the inferior parietal lobe. This new case suggests that: (i) agnosia for mirror stimuli can persist for 5 years after onset and (ii) the posterior part of the right intraparietal sulcus could be critical in the cognitive process of mirror stimuli discrimination. PMID:25037846

  6. Effectiveness of three contingency-nonspecific stimuli on bathroom graffiti prevention in a college setting.

    PubMed

    Lee, Jin; Chung, Kyong-Mee

    2013-04-01

    An A-B-A design was adopted to test the effectiveness of different types of contingency-nonspecific stimuli in the prevention of bathroom graffiti in a college setting. The three stimuli examined in this study have been frequently used to prevent bathroom graffiti in South Korea and they were: (a) "Please do not write, draw, or mark on these walls;" (b) a mirror; and (c) "Courteous people keep public places clean." No graffiti was observed when the first and second stimuli were presented. In contrast, a notable increase in bathroom graffiti was observed when the third sign was presented. The results suggest that a contingency non-specific stimuli posting intervention can be effective in the prevention of bathroom graffiti only when appropriate stimuli are used. The practical implications, including cost-effectiveness, are discussed. PMID:23833871

  7. Psychopathy, aggression, and the processing of emotional stimuli in non-referred girls and boys.

    PubMed

    Kimonis, Eva R; Frick, Paul J; Fazekas, Holly; Loney, Bryan R

    2006-01-01

    Research shows that individuals with psychopathic traits differ in how they process negative emotional stimuli. However, it is unclear whether these differences are specific to certain types of negative emotional stimulus and whether they are more strongly associated with psychopathic traits or aggression. Further, it is not clear whether or not deficits in emotional processing generalize to females and ethnic minority individuals with psychopathic traits. In this study, we examined the emotional processing of visual stimuli using a dot-probe task in 50 non-referred girls and boys (mean age of 9.30; SD = 2.00). Overall, there was a significant association between proactive aggression and reduced responsiveness to distressing stimuli. In addition, the predicted association between psychopathic traits and reduced responsiveness to distressing stimuli was only found for children high on aggression. Also, the associations among aggression, psychopathic traits, and responsiveness to distressing stimuli did not differ for boys and girls. PMID:16491477

  8. Agnosia for Mirror Stimuli: A New Case Report with a Small Parietal Lesion

    PubMed Central

    Martinaud, Olivier; Mirlink, Nicolas; Bioux, Sandrine; Bliaux, Evangéline; Lebas, Axel; Gerardin, Emmanuel; Hannequin, Didier

    2014-01-01

    Only seven cases of agnosia for mirror stimuli have been reported, always with an extensive lesion. We report a new case of an agnosia for mirror stimuli due to a circumscribed lesion. An extensive battery of neuropsychological tests and a new experimental procedure to assess visual object mirror and orientation discrimination were assessed 10 days after the onset of clinical symptoms, and 5 years later. The performances of our patient were compared with those of four healthy control subjects matched for age. This test revealed an agnosia for mirror stimuli. Brain imaging showed a small right occipitoparietal hematoma, encompassing the extrastriate cortex adjoining the inferior parietal lobe. This new case suggests that: (i) agnosia for mirror stimuli can persist for 5 years after onset and (ii) the posterior part of the right intraparietal sulcus could be critical in the cognitive process of mirror stimuli discrimination. PMID:25037846

  9. Learning effects of piano playing on tactile recognition of sequential stimuli.

    PubMed

    Hatta, T; Ejiri, A

    1989-01-01

    To examine the effect of learning experiences of piano playing on a tactile sequential recognition task, two experiments were conducted. In the first experiment, pianists and control subjects were given sequential tactile stimuli and were asked to report the simulated fingers and the order. The pianists showed a left hand superiority and performed better than the control group. In the second experiment, the skilled pianists and the control subjects were given both sequential tactile stimuli and auditory stimuli (unrelated melodies) simultaneously. The sequential stimuli recognition of the skilled pianists was interfered with by the presentation of the unrelated melody, and this tendency was more prominent in their left hand, while the performance of the control subjects was not affected by the presentation of the melody. These results suggest that pianists employed a special strategy, such as transforming tactile stimuli into something like a melody to improve their performance. Based upon these results, effects of learning experiences on hemisphere function were discussed. PMID:2615935

  10. Determination of myopes' visual acuity using stimuli with different contrast

    NASA Astrophysics Data System (ADS)

    Ikaunieks, G.; Caure, E.; Kassaliete, E.; Meskovska, Z.

    2012-10-01

    The influence of different contrast stimuli on the myopes’ visual acuity (VA) was studied using positive (35.7), negative (-0.97) and low contrast (-0.11) Landolt optotypes. Test subjects were 13 myopes with corrected eyesight and 8 emmetropes, all of them being 20-22 years old. For VA determination the FrACT computer program was employed. In the tests it was found that for emmetropes the positive and negative contrast VA values do not differ significantly, while for myopes the respective values are better with positive than with negative contrast stimuli. These differences were the same in the measurements taken with spectacles or contact lenses. Our results also show that the retinal straylight created by clean spectacles or soft contact lenses is similar in both cases. Dažu autoru pētījumi rāda, ka miopijas gadījumā redzes asums ir labāks ar pozitīva Vēbera kontrasta stimuliem (balts stimuls uz melna fona) nekā negatīva kontrasta stimuliem (melns stimuls uz balta fona). Šis fenomens tiek saistītas ar neirālām izmaiņām ON un OFF ceļos un miopiskās acīs. Citi pētījumi rāda, ka arī acī izkliedētās gaismas ietekmē labāks redzes asums ir ar pozitīviem kontrasta stimuliem nekā negatīva. Miopijas gadījumā papildus gaismas izkliedi rada briļļu lēcas vai kontaktlēcas. Mēs savā pētījumā vēlējāmies noskaidrot, cik lielā mērā labāks redzes asums ar pozitīva kontrasta stimuliem miopiskās acīs ir saistāms ar optiskās korekcijas radīto gaismas izkliedi. Pētījumā piedalījās 21 dalībnieks - 8 emetropi un 13 miopi ar sfērisko refrakcijas lielumu no -1.25 līdz -6,25 D. Dalībnieku vecums bija no 20 līdz 22 gadi. Izmantojot FrACT datorprogrammu, tika noteiks monokulārais redzes asums VA ar Landolta gredzeniem pie pozitīva, negatīva un zema kontrasta fotopiskos apstākļos. Vēbera kontrasti stimuliem attiecīgi bija 35.7, -0.97 un -0.11. Miopiem mērījumi tika veikti gan ar brillēm, gan

  11. Visual Stimuli Induce Waves of Electrical Activity in Turtle Cortex

    NASA Astrophysics Data System (ADS)

    Prechtl, J. C.; Cohen, L. B.; Pesaran, B.; Mitra, P. P.; Kleinfeld, D.

    1997-07-01

    The computations involved in the processing of a visual scene invariably involve the interactions among neurons throughout all of visual cortex. One hypothesis is that the timing of neuronal activity, as well as the amplitude of activity, provides a means to encode features of objects. The experimental data from studies on cat [Gray, C. M., Konig, P., Engel, A. K. & Singer, W. (1989) Nature (London) 338, 334-337] support a view in which only synchronous (no phase lags) activity carries information about the visual scene. In contrast, theoretical studies suggest, on the one hand, the utility of multiple phases within a population of neurons as a means to encode independent visual features and, on the other hand, the likely existence of timing differences solely on the basis of network dynamics. Here we use widefield imaging in conjunction with voltage-sensitive dyes to record electrical activity from the virtually intact, unanesthetized turtle brain. Our data consist of single-trial measurements. We analyze our data in the frequency domain to isolate coherent events that lie in different frequency bands. Low frequency oscillations (<5 Hz) are seen in both ongoing activity and activity induced by visual stimuli. These oscillations propagate parallel to the afferent input. Higher frequency activity, with spectral peaks near 10 and 20 Hz, is seen solely in response to stimulation. This activity consists of plane waves and spiral-like waves, as well as more complex patterns. The plane waves have an average phase gradient of ≈ π /2 radians/mm and propagate orthogonally to the low frequency waves. Our results show that large-scale differences in neuronal timing are present and persistent during visual processing.

  12. Stereo correspondence in one-dimensional Gabor stimuli.

    PubMed

    Prince, S J; Eagle, R A

    2000-01-01

    Previous data [Prince, S.J.D., & Eagle, R.A., (1999). Size-disparity correlation in human binocular depth perception. Proceedings of the Royal Society of London B, 266, 1361-1365] have demonstrated that the upper disparity limit for stereopsis (DMax) is considerably smaller in filtered noise stereograms than in isolated Gabor patches of the same spatial frequency. This discrepancy is not currently understood. Here, the solution of the correspondence problem for bandpass stereograms was further examined. On each trial observers were presented with two one-dimensional Gabor stimuli containing disparities of equal magnitude but opposite sign. Subjects were required to indicate which interval contained the crossed disparity stimulus. It was found that matching behaviour changed as a function of Gabor envelope size. As a function of disparity magnitude, performance cycled between mostly correct and mostly incorrect at large envelope sizes but was always correct at small envelope sizes. At intermediate envelope sizes performance was cyclical at small disparities but always correct at large disparities. The critical envelope size at which performance changed from mostly correct to mostly incorrect at 270 degrees phase disparity was used as a measure of the matching performance as other parameters of the Gabor were varied. Both absolute and relative contrast were shown to influence the perceived sign of matches. Critical envelope size was also found to decrease as a function of spatial frequency, but more slowly than a phase-based limit would predict. These data cannot be predicted by current models of stereopsis, and can be used to constrain future models. PMID:10720662

  13. Autonomous adrenocorticotropin reaction to stress stimuli in human fetus.

    PubMed

    Kosinska-Kaczynska, Katarzyna; Bartkowiak, Robert; Kaczynski, Bartosz; Szymusik, Iwona; Wielgos, Miroslaw

    2012-04-01

    The aim of the study was to determine whether human fetuses show ACTH response to stress stimuli, to define the gestational age from which these reactions may be present and to analyze the relationship between hormone concentrations and their changes, both in fetuses and in pregnant women. The study included 81 intrauterine transfusions carried out in 19 pregnant women. 52 procedures were performed directly into the umbilical vein, which is not innervated, so neutral for the fetus (the PCI group) and 29 transfusions into the intrahepatic vein -which puncture is stressful for the fetus (the IHV group). ACTH and cortisol concentrations in fetal and maternal plasma obtained during the procedures were assayed. The initial mean plasma ACTH concentration in the PCI group equaled 18.94pg/mL, but in the IHV group it was significantly higher and amounted 75.17pg/mL (p<0.001). There was no significant change in the hormone concentration during the transfusion both in the IHV group (95.8pg/mL, p>0.05) and in the PCI group (22.36pg/mL, p>0.05). The observed hormonal response in the IHV group proves the existence of fetal pituitary reaction to stress. The initial fetal ACTH concentration in the IHV group correlated with the number of transfusions performed on a single fetus (R=0.41; p=0.04). No correlation with parity, gestational weeks or the volume of transfused packed red blood cells was found. There was also no correlation between fetal and maternal ACTH concentrations in any group. Presented data suggest that the human fetus shows autonomous ACTH reaction to stress stimulation. PMID:21925813

  14. Evidence of Nb-Ta mobility in high temperature F-rich fluids evidenced by the La Bosse quartz-Nb-ferberite stockwork (Echassières, French Massif Central).

    NASA Astrophysics Data System (ADS)

    Marignac, C.; Cuney, M.

    2012-04-01

    In the Echassières district (northern French Massif Central), the 310 Ma Beauvoir granite (a P-rich peraluminous RMG) overprints a quartz-ferberite stockwork. The 900 m-deep GPF1 scientific hole shows that the stockwork is split into two parts by the gently dipping Beauvoir intrusion: the upper section (~ 100m thick) occurs in the La Bosse quarry, , and the lower section (≥ 60 m thick) below the granite floor. The root of the stockwork (hypothetic La Bosse granite) has not been reached. The stockwork comprises flat-lying quartz veins (≤ 0.6 m thick) concordant to the regional schistosity of surrounding micaschists, and steep N10-N50°E quartz veins (≤ 0.2 m thick). The two sets result from hydraulic fracturing, and consistently display crack seal features. A family of aplites and aplo-pegmatites dikes follow the same set of fractures, being either later (with partial dissolution of pre-existing quartz veins) or earlier, than the quartz veins. There is no alteration, nor associated mineral other than ferberite, at the La Bosse quarry, whereas micaceous selvages are observed in the lower section. Ferberite display a trend of ferberite enrichment with increasing depth (0.71 to 0.95 Fb mole%). In the La Bosse quarry, three ferberite habitus are present: acicular, lanceolate and prismatic. Acicular crystals are typically nicely zoned, with alternating Nb-rich (4.95±0.94 % Nb2O5) and Nb-poor (1.57±0.38 % Nb2O5) growth bands. Ta (up to 0.30 Ta2O5), Ti and Sn are also enriched in the Nb-rich bands. Nb and Ta incorporation into the ferberite is in the form of columbite, as either true solid solution or nanoinclusions. Lanceolate crystals have a similarly zoned acicular core and a Nb-poor rim (1.08±0.66 % Nb2O5). Prismatic crystals are unzoned and Nb-poor (0.67±0.20 % Nb2O5). In the lower part of the stockwork, the Nb contents are lower (2.17 % Nb2O5 in the Nb-rich bands, 1.36 % in the Nb-poor bands, 0.08 % in the unzoned cortex, 0.15 % in the unzoned prisms

  15. Evidence of Nb-Ta mobility in high temperature F-rich fluids evidenced by the La Bosse quartz-Nb-ferberite stockwork (Echassières, French Massif Central).

    NASA Astrophysics Data System (ADS)

    Marignac, C.; Cuney, M.

    2012-04-01

    In the Echassières district (northern French Massif Central), the 310 Ma Beauvoir granite (a P-rich peraluminous RMG) overprints a quartz-ferberite stockwork. The 900 m-deep GPF1 scientific hole shows that the stockwork is split into two parts by the gently dipping Beauvoir intrusion: the upper section (~ 100m thick) occurs in the La Bosse quarry, , and the lower section (≥ 60 m thick) below the granite floor. The root of the stockwork (hypothetic La Bosse granite) has not been reached. The stockwork comprises flat-lying quartz veins (≤ 0.6 m thick) concordant to the regional schistosity of surrounding micaschists, and steep N10-N50°E quartz veins (≤ 0.2 m thick). The two sets result from hydraulic fracturing, and consistently display crack seal features. A family of aplites and aplo-pegmatites dikes follow the same set of fractures, being either later (with partial dissolution of pre-existing quartz veins) or earlier, than the quartz veins. There is no alteration, nor associated mineral other than ferberite, at the La Bosse quarry, whereas micaceous selvages are observed in the lower section. Ferberite display a trend of ferberite enrichment with increasing depth (0.71 to 0.95 Fb mole%). In the La Bosse quarry, three ferberite habitus are present: acicular, lanceolate and prismatic. Acicular crystals are typically nicely zoned, with alternating Nb-rich (4.95±0.94 % Nb2O5) and Nb-poor (1.57±0.38 % Nb2O5) growth bands. Ta (up to 0.30 Ta2O5), Ti and Sn are also enriched in the Nb-rich bands. Nb and Ta incorporation into the ferberite is in the form of columbite, as either true solid solution or nanoinclusions. Lanceolate crystals have a similarly zoned acicular core and a Nb-poor rim (1.08±0.66 % Nb2O5). Prismatic crystals are unzoned and Nb-poor (0.67±0.20 % Nb2O5). In the lower part of the stockwork, the Nb contents are lower (2.17 % Nb2O5 in the Nb-rich bands, 1.36 % in the Nb-poor bands, 0.08 % in the unzoned cortex, 0.15 % in the unzoned prisms

  16. Viewing Sexual Stimuli Associated with Greater Sexual Responsiveness, Not Erectile Dysfunction

    PubMed Central

    Prause, Nicole; Pfaus, James

    2015-01-01

    Introduction Time spent viewing visual sexual stimuli (VSS) has the potential to habituate the sexual response and generalize to the partner context. Aim The aim of this study was to examine whether the time spent viewing VSS is related to sexual responsiveness felt in the laboratory or with a sexual partner. Methods Nontreatment-seeking men (N = 280) reported their weekly average VSS viewing in hours. VSS hours were examined in relation to the sexual arousal experienced while viewing a standardized sexual film in the laboratory and erectile problems experienced with a sexual partner. Main Outcome Measures Self-reported sexual arousal in response to sexual films and erectile problems on the International Index of Erectile Function were the main outcome measures. Results More hours viewing VSS was related to stronger experienced sexual responses to VSS in the laboratory, was unrelated to erectile functioning with a partner, and was related to stronger desire for sex with a partner. Conclusions VSS use within the range of hours tested is unlikely to negatively impact sexual functioning, given that responses actually were stronger in those who viewed more VSS. PMID:26185674

  17. Manipulation of heart rate variability can modify response to anger-inducing stimuli.

    PubMed

    Francis, Heather M; Penglis, Kathryn M; McDonald, Skye

    2016-10-01

    Research suggests that heart rate variability (HRV) is a physiological indicator of the flexibility of the autonomic nervous system and can provide an objective measure of an individual's ability to appropriately match emotional responses to environmental demands. The present study investigated whether angry response to emotional stimuli was related to HRV, and whether manipulation of HRV using biofeedback could change the anger response in a healthy adult population. Fifty-eight participants received HRV biofeedback (n = 29) or an active control condition (n = 29). HRV measures included standard deviation of normal-to-normal intervals (SDNN), low-frequency (LF) and high-frequency (HF) power, and was recorded across three sessions: baseline, training, and anger induction. The anger induction procedure resulted in increased subjective experience of anger, as well as physiological changes. The biofeedback group had higher HRV than active controls both during the training session (SDNN and LF HRV) and during anger induction (LF HRV). HRV during anger induction was significantly associated with self-reported emotional response for participants receiving biofeedback but not for active controls. Results provide support for HRV as an index of emotion regulation, specifically anger. Further research is needed to determine whether long-term HRV biofeedback can have a lasting effect on managing anger. PMID:26592092

  18. Cardio-visual integration modulates the subjective perception of affectively neutral stimuli.

    PubMed

    Azevedo, Ruben T; Ainley, Vivien; Tsakiris, Manos

    2016-01-01

    Interoception, which refers to the perception of internal body signals, has been consistently associated with emotional processing and with the sense of self. However, its influence on the subjective appraisal of affectively neutral and body-unrelated stimuli is still largely unknown. Across two experiments we sought to investigate this issue by asking participants to detect changes in the flashing rhythm of a simple stimulus (a circle) that could either be pulsing synchronously with their own heartbeats or following the pattern of another person's heart. While overall task performance did not vary as a function of cardio-visual synchrony, participants were better at identifying trials in which no change occurred when the flashes were synchronous with their own heartbeats. This study adds to the growing body of research indicating that we use our body as a reference point when perceiving the world; and extends this view by focusing on the role that signals coming from inside the body, such as heartbeats, may play in this referencing process. Specifically we show that private interoceptive sensations can be combined with affectively neutral information unrelated to the self to influence the processing of a multisensory percept. Results are discussed in terms of both standard multisensory integration processes and predictive coding theories. PMID:26620928

  19. Innovative testing of spatial ability: interactive responding and the use of complex stimuli material.

    PubMed

    Jelínek, Martin; Květon, Petr; Vobořil, Dalibor

    2015-02-01

    Despite initial expectations, which have emerged with the advancement of computer technology over the last decade of the twentieth century, scientific literature does not contain many relevant references regarding the development and use of innovative items in psychological testing. Our study presents and evaluates two novel item types. One item type is derived from a standard schematic test item used for the assessment of the spatial perception aspect of spatial ability, enhanced by an interactive response module. The performance on this item type is correlated with the performance on its paper and pencil counterpart. The other innovative item type used complex stimuli in the form of a short video of a ride through a city presented in an on-route perspective, which is intended to measure navigation skills and the ability to keep oneself oriented in space. In this case, the scores were related to the capacity of visuo-spatial working memory and also to the overall score in the paper/pencil test of spatial ability. The second relationship was moderated by gender. PMID:25362549

  20. First- and Second-Order Stimuli Reaction Time Measures Are Highly Sensitive to Mild Traumatic Brain Injuries.

    PubMed

    Piponnier, Jean-Claude; Forget, Robert; Gagnon, Isabelle; McKerral, Michelle; Giguère, Jean-François; Faubert, Jocelyn

    2016-01-15

    Mild traumatic brain injury (mTBI) has subtle effects on several brain functions that can be difficult to assess and follow up. We investigated the impact of mTBI on the perception of sine-wave gratings defined by first- and second-order characteristics. Fifteen adults diagnosed with mTBI were assessed at 15 days, 3 months, and 12 months postinjury. Fifteen matched controls followed the same testing schedule. Reaction times (RTs) for flicker detection and motion direction discrimination were measured. Stimulus contrast of first- and second-order patterns was equated to control for visibility, and correct-response RT means, standard deviations (SDs), medians, and interquartile ranges (IQRs) were calculated. The level of symptoms was also evaluated to compare it to RT data. In general in mTBI, RTs were longer, and SDs as well as IQRs larger, than those of controls. In addition, mTBI participants' RTs to first-order stimuli were shorter than those to second-order stimuli, and SDs as well as IQRs larger for first- than for second-order stimuli in the motion condition. All these observations were made over the three sessions. The level of symptoms observed in mTBI was higher than that of control participants, and this difference did also persist up to 1 year after the brain injury, despite an improvement. The combination of RT measures with particular stimulus properties is a highly sensitive method for measuring mTBI-induced visuomotor anomalies and provides a fine probe of the underlying mechanisms when the brain is exposed to mild trauma. PMID:25950948

  1. 'I wanted to be boss'.

    PubMed

    Trueland, Jennifer

    2015-10-01

    The ability to decide what has to be done now and what can wait has served Royal Blackburn Hospital matron for medicine and the medical admissions unit Lesley Gaw well in the three decades that she's been scaling the leadership ladder. But it could all have been so different, as Jennifer Trueland discovered when she met the innovative nurse manager. PMID:26419576

  2. Polymeric variable optical attenuators based on magnetic sensitive stimuli materials

    NASA Astrophysics Data System (ADS)

    de Pedro, S.; Cadarso, V. J.; Ackermann, T. N.; Muñoz-Berbel, X.; Plaza, J. A.; Brugger, J.; Büttgenbach, S.; Llobera, A.

    2014-12-01

    Magnetically-actuable, polymer-based variable optical attenuators (VOA) are presented in this paper. The design comprises a cantilever which also plays the role of a waveguide and the input/output alignment elements for simple alignment, yet still rendering an efficient coupling. Magnetic properties have been conferred to these micro-opto-electromechanical systems (MOEMS) by implementing two different strategies: in the first case, a magnetic sensitive stimuli material (M-SSM) is obtained by a combination of polydimethylsiloxane (PDMS) and ferrofluid (FF) in ratios between 14.9 wt % and 29.9 wt %. An M-SSM strip under the waveguide-cantilever, defined with soft lithography (SLT), provides the required actuation capability. In the second case, specific volumes of FF are dispensed at the end of the cantilever tip (outside the waveguide) by means of inkjet printing (IJP), obtaining the required magnetic response while holding the optical transparency of the waveguide-cantilever. In the absence of a magnetic field, the waveguide-cantilever is aligned with the output fiber optics and thus the intrinsic optical losses can be obtained. Numerical simulations, validated experimentally, have shown that, for any cantilever length, the VOAs defined by IJP present lower intrinsic optical losses than their SLT counterparts. Under an applied magnetic field (Bapp), both VOA configurations experience a misalignment between the waveguide-cantilever and the output fiber optics. Thus, the proposed VOAs modulate the output power as a function of the cantilever displacement, which is proportional to Bapp. The experimental results for the three different waveguide-cantilever lengths and six different FF concentrations (three per technology) show maximum deflections of 220 µm at 29.9 wt % of FF for VOASLT and 250 µm at 22.3 wt % FF for VOAIJP, at 0.57 kG for both. These deflections provide maximum actuation losses of 16.1 dB and 18.9 dB for the VOASLT and VOAIJP

  3. Auditory ERP response to successive stimuli in infancy

    PubMed Central

    Peter, Varghese; Burnham, Denis

    2016-01-01

    Background. Auditory Event-Related Potentials (ERPs) are useful for understanding early auditory development among infants, as it allows the collection of a relatively large amount of data in a short time. So far, studies that have investigated development in auditory ERPs in infancy have mainly used single sounds as stimuli. Yet in real life, infants must decode successive rather than single acoustic events. In the present study, we tested 4-, 8-, and 12-month-old infants’ auditory ERPs to musical melodies comprising three piano notes, and examined ERPs to each individual note in the melody. Methods. Infants were presented with 360 repetitions of a three-note melody while EEG was recorded from 128 channels on the scalp through a Geodesic Sensor Net. For each infant, both latency and amplitude of auditory components P1 and N2 were measured from averaged ERPs for each individual note. Results. Analysis was restricted to response collected at frontal central site. For all three notes, there was an overall reduction in latency for both P1 and N2 over age. For P1, latency reduction was significant from 4 to 8 months, but not from 8 to 12 months. N2 latency, on the other hand, decreased significantly from 4 to 8 to 12 months. With regard to amplitude, no significant change was found for either P1 or N2. Nevertheless, the waveforms of the three age groups were qualitatively different: for the 4-month-olds, the P1–N2 deflection was attenuated for the second and the third notes; for the 8-month-olds, such attenuation was observed only for the middle note; for the 12-month-olds, the P1 and N2 peaks show relatively equivalent amplitude and peak width across all three notes. Conclusion. Our findings indicate that the infant brain is able to register successive acoustic events in a stream, and ERPs become better time-locked to each composite event over age. Younger infants may have difficulties in responding to late occurring events in a stream, and the onset response to

  4. Auditory ERP response to successive stimuli in infancy.

    PubMed

    Chen, Ao; Peter, Varghese; Burnham, Denis

    2016-01-01

    Background. Auditory Event-Related Potentials (ERPs) are useful for understanding early auditory development among infants, as it allows the collection of a relatively large amount of data in a short time. So far, studies that have investigated development in auditory ERPs in infancy have mainly used single sounds as stimuli. Yet in real life, infants must decode successive rather than single acoustic events. In the present study, we tested 4-, 8-, and 12-month-old infants' auditory ERPs to musical melodies comprising three piano notes, and examined ERPs to each individual note in the melody. Methods. Infants were presented with 360 repetitions of a three-note melody while EEG was recorded from 128 channels on the scalp through a Geodesic Sensor Net. For each infant, both latency and amplitude of auditory components P1 and N2 were measured from averaged ERPs for each individual note. Results. Analysis was restricted to response collected at frontal central site. For all three notes, there was an overall reduction in latency for both P1 and N2 over age. For P1, latency reduction was significant from 4 to 8 months, but not from 8 to 12 months. N2 latency, on the other hand, decreased significantly from 4 to 8 to 12 months. With regard to amplitude, no significant change was found for either P1 or N2. Nevertheless, the waveforms of the three age groups were qualitatively different: for the 4-month-olds, the P1-N2 deflection was attenuated for the second and the third notes; for the 8-month-olds, such attenuation was observed only for the middle note; for the 12-month-olds, the P1 and N2 peaks show relatively equivalent amplitude and peak width across all three notes. Conclusion. Our findings indicate that the infant brain is able to register successive acoustic events in a stream, and ERPs become better time-locked to each composite event over age. Younger infants may have difficulties in responding to late occurring events in a stream, and the onset response to the

  5. Women's interest in visual sexual stimuli varies with menstrual cycle phase at first exposure and predicts later interest.

    PubMed

    Wallen, Kim; Rupp, Heather A

    2010-02-01

    This study investigated whether women's interest in visual sexual stimuli varied with their hormonal state. Viewing times of 30 women, 15 normal cycling (NC) and 15 oral contracepting (OC), to sexually explicit photos were measured at three different times. NC women were tested during their menstrual, periovulatory, and luteal phases, and OC women were tested at equivalent temporal intervals. Subjects viewed stimuli as long as desired, thus viewing time measured subject interest. Subjective ratings of stimulus sexual attractiveness were obtained on each test. There was no overall relationship between menstrual cycle phase and viewing time. However the participant's menstrual cycle phase during first exposure to sexual stimuli predicted subsequent interest in sexual stimuli during the next two tests. NC women who first viewed stimuli during their periovulatory phase looked longer at the sexual stimuli across all sessions than did women first tested in their luteal phase. OC women first exposed to the sexual stimuli during menstruation looked longer at the stimuli across all sessions than did OC women first exposed at other test phases. Neither current test phase nor initial cycle phase influenced subjective ratings. Women had increased interest in sexual stimuli across all sessions if first exposed to sexual stimuli when endogenous estrogens were most likely highest. These data suggest that women's interest in visual sexual stimuli is modulated by hormones such that the hormonal condition at first exposure possibly determines the stimuli's emotional valence, markedly affecting subsequent interest in sexual stimuli. PMID:20034495

  6. The Value of Social Attributes of Stimuli for Promoting Engagement in Persons With Dementia

    PubMed Central

    Cohen-Mansfield, Jiska; Thein, Khin; Dakheel-Ali, Maha; Regier, Natalie G.; Marx, Marcia S.

    2011-01-01

    The present study examined the impact of different attributes of social stimuli using the stimulus attributes aspect of the Comprehensive Process Model of Engagement (Cohen-Mansfield et al., (2009a) Am J Geriatr Psychiatry. 17:299–307). Participants were 193 residents of 7 Maryland nursing homes with a diagnosis of dementia. Stimuli were chosen to represent different levels of the following social attributes: social versus not social, realistic versus not realistic, animated versus nonanimated, human versus nonhuman, and alive versus not alive. Participants had significantly longer engagement, were significantly more attentive, and displayed a significantly more positive attitude with social stimuli than with nonsocial stimuli. Longer durations and higher ratings of attention and attitude were seen with realistic and animated stimuli as compared to their counterparts. Human and live stimuli resulted in significantly more engagement than their counterparts. Giving any social stimulus to the residents is preferable to providing none, and the social attributes of stimuli should be maximized. PMID:20699725

  7. Resistance to change and frequency of response-dependent stimuli uncorrelated with reinforcement.

    PubMed

    Podlesnik, Christopher A; Jimenez-Gomez, Corina; Ward, Ryan D; Shahan, Timothy A

    2009-09-01

    Stimuli uncorrelated with reinforcement have been shown to enhance response rates and resistance to disruption; however, the effects of different rates of stimulus presentations have not been assessed. In two experiments, we assessed the effects of adding different rates of response-dependent brief stimuli uncorrelated with primary reinforcement on relative response rates and resistance to change. In both experiments, pigeons responded on variable-interval 60-s schedules of food reinforcement in two components of a multiple schedule, and brief response-dependent keylight-color changes were added to one or both components. Although relative response rates were not systematically affected in either experiment, relative resistance to presession feeding and extinction were. In Experiment 1, adding stimuli on a variable-interval schedule to one component of a multiple schedule either at a low rate (1 per min) for one group or at a high rate (4 per min) for another group similarly increased resistance to disruption in the components with added stimuli. When high and low rates of stimuli were presented across components (i.e., within subjects) in Experiment 2, however, relative resistance to disruption was greater in the component presenting stimuli at a lower rate. These results suggest that stimuli uncorrelated with food reinforcement do not strengthen responding in the same way as primary reinforcers. PMID:20354599

  8. Resistance to Change and Frequency of Response-Dependent Stimuli Uncorrelated with Reinforcement

    PubMed Central

    Podlesnik, Christopher A; Jimenez-Gomez, Corina; Ward, Ryan D; Shahan, Timothy A

    2009-01-01

    Stimuli uncorrelated with reinforcement have been shown to enhance response rates and resistance to disruption; however, the effects of different rates of stimulus presentations have not been assessed. In two experiments, we assessed the effects of adding different rates of response-dependent brief stimuli uncorrelated with primary reinforcement on relative response rates and resistance to change. In both experiments, pigeons responded on variable-interval 60-s schedules of food reinforcement in two components of a multiple schedule, and brief response-dependent keylight-color changes were added to one or both components. Although relative response rates were not systematically affected in either experiment, relative resistance to presession feeding and extinction were. In Experiment 1, adding stimuli on a variable-interval schedule to one component of a multiple schedule either at a low rate (1 per min) for one group or at a high rate (4 per min) for another group similarly increased resistance to disruption in the components with added stimuli. When high and low rates of stimuli were presented across components (i.e., within subjects) in Experiment 2, however, relative resistance to disruption was greater in the component presenting stimuli at a lower rate. These results suggest that stimuli uncorrelated with food reinforcement do not strengthen responding in the same way as primary reinforcers. PMID:20354599

  9. Increasing Cognitive Load Reduces Interference from Masked Appetitive and Aversive but Not Neutral Stimuli

    PubMed Central

    Uher, Rudolf; Brooks, Samantha J.; Bartholdy, Savani; Tchanturia, Kate; Campbell, Iain C.

    2014-01-01

    Interactions between cognition and emotion are important for survival, often occurring in the absence of awareness. These interactions have been proposed to involve competition between cognition and emotion for attentional resources. Emotional stimuli have been reported to impair performance on cognitive tasks of low, but not high, load if stimuli are consciously perceived. This study explored whether this load-dependent interference effect occurred in response to subliminal emotional stimuli. Masked emotional (appetitive and aversive), but not neutral, stimuli interfered with performance accuracy but not response time on a cognitive task (n-back) at low (1-back), but not high (2-back) load. These results show that a load-dependent interference effect applies to masked emotional stimuli and that the effect generalises across stimulus categories with high motivational value. This supports models of selective attention that propose that cognition and emotion compete for attentional resources. More specifically, interference from masked emotional stimuli at low load suggests that attention is biased towards salient stimuli, while dissipation of interference under high load involves top-down regulation of attention. Our data also indicate that top-down goal-directed regulation of attention occurs in the absence of awareness and does not require metacognitive monitoring or evaluation of bias over behaviour, i.e., some degree of self-regulation occurs at a non-conscious level. PMID:24709953

  10. Environmental Interactions and Epistasis Are Revealed in the Proteomic Responses to Complex Stimuli

    PubMed Central

    Samir, Parimal; Rahul; Slaughter, James C.; Link, Andrew J.

    2015-01-01

    Ultimately, the genotype of a cell and its interaction with the environment determine the cell’s biochemical state. While the cell’s response to a single stimulus has been studied extensively, a conceptual framework to model the effect of multiple environmental stimuli applied concurrently is not as well developed. In this study, we developed the concepts of environmental interactions and epistasis to explain the responses of the S. cerevisiae proteome to simultaneous environmental stimuli. We hypothesize that, as an abstraction, environmental stimuli can be treated as analogous to genetic elements. This would allow modeling of the effects of multiple stimuli using the concepts and tools developed for studying gene interactions. Mirroring gene interactions, our results show that environmental interactions play a critical role in determining the state of the proteome. We show that individual and complex environmental stimuli behave similarly to genetic elements in regulating the cellular responses to stimuli, including the phenomena of dominance and suppression. Interestingly, we observed that the effect of a stimulus on a protein is dominant over other stimuli if the response to the stimulus involves the protein. Using publicly available transcriptomic data, we find that environmental interactions and epistasis regulate transcriptomic responses as well. PMID:26247773

  11. Comparison of EEG propagation speeds under emotional stimuli on smartphone between the different anxiety states

    PubMed Central

    Asakawa, Tetsuya; Muramatsu, Ayumi; Hayashi, Takuto; Urata, Tatsuya; Taya, Masato; Mizuno-Matsumoto, Yuko

    2014-01-01

    The current study evaluated the effect of different anxiety states on information processing as measured by an electroencephalography (EEG) using emotional stimuli on a smartphone. Twenty-three healthy subjects were assessed for their anxiety states using The State Trait Anxiety Inventory (STAI) and divided into two groups: low anxiety (I, II) or high anxiety (III and IV, V). An EEG was performed while the participant was presented with emotionally laden audiovisual stimuli (resting, pleasant, and unpleasant sessions) and emotionally laden sentence stimuli (pleasant sentence, unpleasant sentence sessions) and EEG data was analyzed using propagation speed analysis. The propagation speed of the low anxiety group at the medial coronal for resting stimuli for all time segments was higher than those of high anxiety group. The low anxiety group propagation speeds at the medial sagittal for unpleasant stimuli in the 0–30 and 60–150 s time frames were higher than those of high anxiety group. The propagation speeds at 150 s for all stimuli in the low anxiety group were significantly higher than the correspondent propagation speeds of the high anxiety group. These events suggest that neural information processes concerning emotional stimuli differ based on current anxiety state. PMID:25540618

  12. Comparison of EEG propagation speeds under emotional stimuli on smartphone between the different anxiety states.

    PubMed

    Asakawa, Tetsuya; Muramatsu, Ayumi; Hayashi, Takuto; Urata, Tatsuya; Taya, Masato; Mizuno-Matsumoto, Yuko

    2014-01-01

    The current study evaluated the effect of different anxiety states on information processing as measured by an electroencephalography (EEG) using emotional stimuli on a smartphone. Twenty-three healthy subjects were assessed for their anxiety states using The State Trait Anxiety Inventory (STAI) and divided into two groups: low anxiety (I, II) or high anxiety (III and IV, V). An EEG was performed while the participant was presented with emotionally laden audiovisual stimuli (resting, pleasant, and unpleasant sessions) and emotionally laden sentence stimuli (pleasant sentence, unpleasant sentence sessions) and EEG data was analyzed using propagation speed analysis. The propagation speed of the low anxiety group at the medial coronal for resting stimuli for all time segments was higher than those of high anxiety group. The low anxiety group propagation speeds at the medial sagittal for unpleasant stimuli in the 0-30 and 60-150 s time frames were higher than those of high anxiety group. The propagation speeds at 150 s for all stimuli in the low anxiety group were significantly higher than the correspondent propagation speeds of the high anxiety group. These events suggest that neural information processes concerning emotional stimuli differ based on current anxiety state. PMID:25540618

  13. Bioinspired Dual Stimuli-Responsive Membranous System with Multiple On-Off Gates.

    PubMed

    Lee, Bom-Yi; Hyun, Seung; Jeon, Gumhye; Kim, Eun Young; Kim, Jinhwan; Kim, Won Jong; Kim, Jin Kon

    2016-05-11

    Stimuli-responsive polymers have been widely used for controlled release of several biomolecules. In general, a single stimulus among various stimuli, for instance, temperature, pH, or light, has been used for these polymers. Although some stimuli are applied together, one cannot control each stimulus independently at a given stimulus-responsive polymer. However, to mimic biological system like cell membrane, multiple on-off gates utilizing independent control of dual (or multiple) stimuli should be used. Here, we introduce a stimuli-responsive membrane controlled by two orthogonal stimuli. For this purpose, the top and the bottom parts of anodized aluminum oxide membrane walls are independently grafted by thermoresponsive poly(N-isopropylacrylamide) and pH-responsive poly(acrylic acid), respectively, by using surface-initiated atom transfer radical polymerization. The membrane clearly showed two independent on-off gates depending on temperature and pH. Furthermore, through light irradiation of two different wavelengths (near-infrared and ultraviolet), temperature and pH were also controlled independently and promptly. Thus, this membrane shows two independent on-off gating of the transport of a model biomolecule of fluorescein isothiocyanate-labeled bovine serum albumin. This strategy suggests the potential of independently modified membrane in layers as stimuli-responsive on-off gates for the application of artificial cell membrane. PMID:27089551

  14. Improvement of Postural Stability During Quiet Standing Obtained After Mental Rotation of Foot Stimuli.

    PubMed

    Kawasaki, Tsubasa; Higuchi, Takahiro

    2016-01-01

    In a study on postural stability, the authors examined whether the effects of mental rotation (MR) intervention using a foot stimulus would last for a relatively long time (up to 60 min). The participants performed a randomly assigned MR task (using foot stimuli, hand stimuli, or non-body-related stimuli [car]) for 10 min. The amount of body sway during unipedal standing was measured immediately after the intervention and 10, 30, and 60 min after the intervention. Results showed that MR intervention using foot stimuli was more effective than that using hand or car stimuli. This suggests that foot stimuli, rather than body-related stimuli, would be advantageous for the intervention. The results show that beneficial effects were observed 60 min after the intervention; this indicates that the effects of the foot MR were unlikely to be explained on the basis of enhanced corticospinal excitability involving motor execution. The authors discuss a potential explanation for the effects and application of the MR task in a clinical setting. PMID:27162153

  15. Development of silicon microforce sensors integrated with double meander springs for standard hardness test instruments

    NASA Astrophysics Data System (ADS)

    Wasisto, Hutomo Suryo; Doering, Lutz; Daus, Alwin; Brand, Uwe; Frank, Thomas; Peiner, Erwin

    2015-05-01

    Silicon microforce sensors, to be used as a transferable standard for micro force and depth scale calibrations of hardness testing instruments, are developed using silicon bulk micromachining technologies. Instead of wet chemical etching, inductively coupled plasma (ICP) cryogenic deep reactive ion etching (DRIE) is employed in the sensor fabrication process leading to more precise control of 300 μm deep structures with smooth sidewall profiles. Double meander springs are designed flanking to the boss replacing the conventional rectangular springs and thereby improving the system linearity. Two full p-SOI piezoresistive Wheatstone bridges are added on both clamped ends of the active sensors. To realize passive force sensors two spring-mass elements are stacked using glue and photoresist as joining materials. Correspondingly, although plastic deformation seems to occur when the second spring is contacted, the kink effect (i.e., abrupt increase of stiffness) is obviously observed from the first test of the passive stack sensor.

  16. Auditory Stimuli Mimicking Ambient Sounds Drive Temporal “Delta-Brushes” in Premature Infants

    PubMed Central

    Chipaux, Mathilde; Colonnese, Matthew T.; Mauguen, Audrey; Fellous, Laure; Mokhtari, Mostafa; Lezcano, Oscar; Milh, Mathieu; Dulac, Olivier; Chiron, Catherine; Khazipov, Rustem; Kaminska, Anna

    2013-01-01

    In the premature infant, somatosensory and visual stimuli trigger an immature electroencephalographic (EEG) pattern, “delta-brushes,” in the corresponding sensory cortical areas. Whether auditory stimuli evoke delta-brushes in the premature auditory cortex has not been reported. Here, responses to auditory stimuli were studied in 46 premature infants without neurologic risk aged 31 to 38 postmenstrual weeks (PMW) during routine EEG recording. Stimuli consisted of either low-volume technogenic “clicks” near the background noise level of the neonatal care unit, or a human voice at conversational sound level. Stimuli were administrated pseudo-randomly during quiet and active sleep. In another protocol, the cortical response to a composite stimulus (“click” and voice) was manually triggered during EEG hypoactive periods of quiet sleep. Cortical responses were analyzed by event detection, power frequency analysis and stimulus locked averaging. Before 34 PMW, both voice and “click” stimuli evoked cortical responses with similar frequency-power topographic characteristics, namely a temporal negative slow-wave and rapid oscillations similar to spontaneous delta-brushes. Responses to composite stimuli also showed a maximal frequency-power increase in temporal areas before 35 PMW. From 34 PMW the topography of responses in quiet sleep was different for “click” and voice stimuli: responses to “clicks” became diffuse but responses to voice remained limited to temporal areas. After the age of 35 PMW auditory evoked delta-brushes progressively disappeared and were replaced by a low amplitude response in the same location. Our data show that auditory stimuli mimicking ambient sounds efficiently evoke delta-brushes in temporal areas in the premature infant before 35 PMW. Along with findings in other sensory modalities (visual and somatosensory), these findings suggest that sensory driven delta-brushes represent a ubiquitous feature of the human sensory

  17. fMRI measurement of the integrative effects of visual and chemical senses stimuli in humans.

    PubMed

    Tonoike, Mitsuo; Yoshida, Tatsuya; Sakuma, Hiroyuki; Wang, Li-Qun

    2013-09-01

    The purpose of this study was to evaluate the integrative effects of visual stimuli with chemical senses (olfactory and gustatory) stimuli in humans. Noninvasive measurement tools such as magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) are used to describe the mechanism of olfactory information processing in the human brain, and the neurophysiological properties of olfactory-related neurons are described. The first study analyzed the interaction between visual and olfactory stimuli. Two odors (lemon and iso-valeric acid) were selected as pleasant and unpleasant odors, respectively and pleasant and unpleasant images were also selected. These cross-modal stimulus combinations were presented to the subject at random, and responses were measured by fMRI using an event related task. These results revealed that active brain areas with pleasant/unpleasant stimuli and matched/mismatched stimuli were different for memory and cognition. The second study analyzed the interaction between visual and gustatory stimuli. Total four conditions (hunger-not hunger, and intake-not intake of monosodium glutamate (MSG)) were tested. Visual stimuli were food-related and nonfood-related photos. A visual analog scale (VAS) was also used to evaluate before and at regular time intervals after intake of MSG, and responses were measured using fMRI. Brain activity related to feeding desire after intake of MSG occurred near the insula cortex, and orbito-frontal cortex, among other areas. These results on the integrative effects of visual stimuli with olfactory and gustatory stimuli, cross-modal and complex effects on olfaction and gustation were suggested to be obtained as an emotional response such as "pleasantness/unpleasantness" and as cognitive and memory responses such as "matching/mismatching" or the responses such as "feeding desire" afterwards intake of foods. PMID:24070060

  18. Method for generating realistic sound stimuli with given characteristics by controlled combination of audio recordings.

    PubMed

    Accolti, Ernesto; Miyara, Federico

    2015-01-01

    Audio recordings are often used to improve ecological validity of stimuli for laboratory research on effects of noise. In this paper a method is proposed for composing realistic environmental sound stimuli with (1) specified overall spectrum and (2) specified statistical distribution of sound event durations and semantic categories. The combination is addressed as a mixed integer linear programming problem. Objective measurements, for eight stimuli and a moderate-size database, validate the method. The mean error in octave bands exposure level is 2.6 dB and the statistical distribution of sound event durations and semantic categories is perfectly matched. PMID:25618105

  19. The BOSS and BIOMEX space experiments on the EXPOSE-R2 mission: Endurance of the desert cyanobacterium Chroococcidiopsis under simulated space vacuum, Martian atmosphere, UVC radiation and temperature extremes.

    NASA Astrophysics Data System (ADS)

    Baqué, Mickael; de Vera, Jean-Pierre; Rettberg, Petra; Billi, Daniela

    2013-10-01

    The proposed space experiments BOSS (Biofilm Organisms Surfing Space) and BIOMEX (BIOlogy and Mars experiment) will take place on the space exposure facility EXPOSE-R2 on the International Space Station (ISS), which is set to be launched in 2014. In BOSS the hypothesis to be tested is that microorganisms grown as biofilms, hence embedded in self-produced extracellular polymeric substances, are more tolerant to space and Martian conditions compared to their planktonic counterparts. Various microbial biofilms have been developed including those obtained from the cyanobacterium Chroococcidiopsis isolated from hot and cold deserts. The prime objective of BIOMEX is to evaluate to what extent biomolecules are resistant to, and can maintain their stability under, space and Mars-like conditions; therefore a variety of pigments and cell components are under investigation to establish a biosignature data base; e.g. a Raman spectral library to be used for extraterrestrial life biosignatures. The secondary objective of BIOMEX is to investigate the endurance of extremophiles, focusing on their interactions with Lunar and Martian mineral analogues. Ground-based studies are currently being carried out in the framework of EVTs (Experiment Verification Tests) by exposing selected organisms to space and Martian simulations. Results on a desert strain of Chroococcidiopsis obtained from the first set of EVT, e.g. space vacuum, Mars atmosphere, UVC radiation, temperature cycles and extremes, suggested that dried biofilms exhibited an enhanced survival compared to planktonic lifestyle. Moreover the protection provided by a Martian mineral analogue (S-MRS) to the sub-cellular integrities of Chroococcidiopsis against UVC radiation supports the endurance of this cyanobacterium under extraterrestrial conditions and its relevance in the development of life detection strategies.

  20. A Systematic Desensitization Paradigm to Treat Hypersensitivity to Auditory Stimuli in Children with Autism in Family Contexts

    ERIC Educational Resources Information Center

    Koegel, Robert L.; Openden, Daniel; Koegel, Lynn Kern

    2004-01-01

    Many children with autism display reactions to auditory stimuli that seem as if the stimuli were painful or otherwise extremely aversive. This article describes, within the contexts of three experimental designs, how procedures of systematic desensitization can be used to treat hypersensitivity to auditory stimuli in three young children with…