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1

The shortest modulation period Blazhko RR Lyrae star: SS Cnc  

E-print Network

Extended BV(RI)c CCD observations of SS Cnc, a short period RRab star are presented. Nearly 1400 data points in each band have been obtained spanning over 79 days during the spring of 2005. The star exhibits light curve modulation, the so called Blazhko effect with small amplitude (B maximum brightness varies 0.1 mag) and with the shortest modulation period (5.309 d) ever observed. In the Fourier spectrum of the V light curve the pulsation frequency components are detected up to the 24th harmonic order, and modulation side lobe frequencies with significantly asymmetric amplitudes are seen up to the 15th and 9th orders for the lower and higher frequency components, respectively. Detailed comparison of the modulation behavior of SS Cnc and RR Gem, the two recently discovered small amplitude, short modulation period Blazhko stars is presented. The modulation frequency (f_m) appears in the Fourier spectrum of both stars with similar amplitude. We also demonstrate that the modulation frequencies have basically different properties as the pulsation and modulation side lobe frequencies have, indicating that the physics behind these frequency components are not the same. The discovery of small amplitude modulations of RRab stars cautions that the large photometric surveys (MACHO, OGLE) may seriously underestimate the number of modulated RR Lyrae stars.

J. Jurcsik; B. Szeidl; Á. Sódor; I. Dékány; Zs. Hurta; K. Posztobányi; K. Vida; M. Váradi; A. Szing

2006-03-20

2

RS CVn stars - Chromospheric phenomena  

NASA Technical Reports Server (NTRS)

The observational information regarding chromospheric emission features in surface-active RS CVn stars is reviewed. Three optical features are considered in detail: Ca II H and K, Balmer H-alpha and He I 10830 A. While the qualitative behavior of these lines is in accord with solar-analogy/rotation-activity ideas, the quantitative variation and scaling are very poorly understood. In many cases, the spectroscopic observations with sufficient SNR and resolution to decide these questions have simply not yet been made. The FK Com stars, in particular, present extreme examples of rotation that may well tax present understanding of surface activity to its limits.

Bopp, B. W.

1983-01-01

3

Infrared observations of RS CVn stars  

NASA Technical Reports Server (NTRS)

The paper presents infrared photometry of the RS CVn binary stars AR Lac (1.2-10 microns) and MM Her (1.2-3.5 microns) as they egressed from their primary and secondary eclipses; of the eclipsing systems RS CVn and Z Her at maximum light (1.2-10 microns) and of the non-eclipsing systems UX Ari and HR 1099 (1.2-10 microns). An analysis of these and published V data based on flux ratio diagrams (linear analogues of color-color diagrams) shows that G and K stars supply the infrared light of these systems. In AR Lac, the combined light of a G5-K0 subgiant and either a late F dwarf or an early F subgiant can account for the observed visual and infrared light curves. None of these systems shows infrared emission from circumstellar matter. This result is simply understood: dust grains would not be expected to form in the physical conditions surrounding the subgiant, and the corona and chromosphere (whose properties have been deduced from spectroscopic X-ray observations) should not produce appreciable infrared emission.

Berriman, G.; De Campli, W. M.; Werner, M. W.; Hatchett, S. P.

1983-01-01

4

Beryllium abundances in parent stars of extrasolar planets: 16 Cyg A & B and rho 1 Cnc  

E-print Network

The Be II 3131 A doublet has been observed in the solar-type stars 16 Cyg A & B and in the late G-type star rho 1 Cnc, to derive their beryllium abundances. 16 Cyg A & B show similar (solar) beryllium abundances while 16 Cyg B, which has been proposed to have a planetary companion of ~2 M_Jup, is known to be depleted in lithium by a factor larger than 6 with respect to 16 Cyg A. Differences in their rotational histories which could induce different rates of internal mixing of material, and the ingestion of a similar planet by 16 Cyg A are discussed as potential explanations. The existence of two other solar-type stars which are candidates to harbour planetary-mass companions and which show lithium and beryllium abundances close to those of 16 Cyg A, requires a more detailed inspection of the peculiarities of the 16 Cyg system. For rho 1 Cnc, which is the coolest known object candidate to harbour a planetary-mass companion (M > 0.85 M_Jup), we establish a precise upper limit for its beryllium abundance, showing a strong Be depletion which constrains the available mixing mechanisms. Observations of similar stars without companions are required to asses the potential effects of the planetary companion on the observed depletion. It has been recently claimed that rho 1 Cnc appears to be a subgiant. If this were the case, the observed strong Li and Be depletions could be explained by a dilution process taking place during its post-main sequence evolution.

R. J. Garcia Lopez; M. R. Perez de Taoro

1998-03-03

5

Legislation may support STaRS  

NASA Astrophysics Data System (ADS)

Congressman Vernon Ehlers (R, MI) has offered three bills in the House of Representatives that support K-12 science, math, engineering, and technology (SMET) education (Eos, April 18, 2000). Although no dollar amounts are mentioned, the three bills contain numerous provisions for improving and expanding SMET education activities at the Department of Education and the National Science Foundation, and for tax incentives for pre-service teacher education and in-service professional development. Of particular interest is Section 15 of H.R. 4271, the National Science Education Act, which directs the NSF to provide scholarships for K-12 teachers to participate in research programs in government agencies, colleges and universities, or private research establishments. Such scholarships could support AGU's Science Teacher and Research Scientist (STaRS) effort, which is intended to provide opportunities for teachers to participate in research under the direction of AGU scientists, and for those same scientists to participate in science teaching under the teachers' direction.

6

Theoretical studies of the RS Canum Venaticorum stars  

NASA Technical Reports Server (NTRS)

The activity in RS Canum Venaticorum (CVn) is investigated. Models for chromospheric structure are developed and the role of magnetic fields both in the photosphere as well as in the chromosphere and upper atmosphere are examined. T Tau stars are also studied from the same points of view. The properties of magnetic field loops are used to help understand the atmospheric structure in RS CVn stars. The concepts developed in the case of these stars appear to be applicable over a much broader region of the HR diagram. The absence of stable magnetic loops in the atmospheres of late type giant stars suggests that the atmospheres of RS CVn active components are qualitatively distinct from the solar atmosphere.

Mullan, D. J.

1982-01-01

7

MOA-2010-BLG-523: 'FAILED PLANET' = RS CVn STAR  

SciTech Connect

The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A {sub max} {approx} 265 high-magnification microlensing event. The deviations originally seemed consistent with expectations for a planetary companion to the principal lens. We combine long-term photometric monitoring with a previously published high-resolution spectrum taken near peak to demonstrate that this is an RS CVn variable, so that planetary microlensing is not required to explain the light-curve deviations. This is the first spectroscopically confirmed RS CVn star discovered in the Galactic bulge.

Gould, A.; Yee, J. C.; Pinsonneault, M. H.; Dong, Subo; Gaudi, B. S.; Hung, L.-W. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States)] [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Bond, I. A. [Institute for Information and Mathematical Sciences, Massey University, Private Bag 102-904, Auckland 1330 (New Zealand)] [Institute for Information and Mathematical Sciences, Massey University, Private Bag 102-904, Auckland 1330 (New Zealand); Udalski, A. [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland)] [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland); Han, C. [Department of Physics, Chungbuk National University, Cheongju 361-763 (Korea, Republic of)] [Department of Physics, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Jorgensen, U. G. [Niels Bohr Institutet, Kobenhavns Universitet, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark)] [Niels Bohr Institutet, Kobenhavns Universitet, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark); Greenhill, J. [University of Tasmania, School of Mathematics and Physics, Private Bag 37, Hobart, TAS 7001 (Australia)] [University of Tasmania, School of Mathematics and Physics, Private Bag 37, Hobart, TAS 7001 (Australia); Tsapras, Y. [Las Cumbres Observatory Global Telescope Network, 6740B Cortona Dr, Goleta, CA 93117 (United States)] [Las Cumbres Observatory Global Telescope Network, 6740B Cortona Dr, Goleta, CA 93117 (United States); Bensby, T. [Lund Observatory, Department of Astronomy and Theoretical Physics, Box 43, SE-221 00 Lund (Sweden)] [Lund Observatory, Department of Astronomy and Theoretical Physics, Box 43, SE-221 00 Lund (Sweden); Allen, W. [Vintage Lane Observatory, Blenheim (New Zealand)] [Vintage Lane Observatory, Blenheim (New Zealand); Almeida, L. A.; Jablonski, F. [Divisao de Astrofisica, Instituto Nacional de Pesquisas Espaciais, Avenida dos Astronautas, 1758 Sao Jose dos Campos, 12227-010 SP (Brazil)] [Divisao de Astrofisica, Instituto Nacional de Pesquisas Espaciais, Avenida dos Astronautas, 1758 Sao Jose dos Campos, 12227-010 SP (Brazil); Bos, M. [Molehill Astronomical Observatory, North Shore (New Zealand)] [Molehill Astronomical Observatory, North Shore (New Zealand); Christie, G. W. [Auckland Observatory, Auckland (New Zealand)] [Auckland Observatory, Auckland (New Zealand); DePoy, D. L. [Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843-4242 (United States)] [Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843-4242 (United States); Lee, C.-U. [Korea Astronomy and Space Science Institute, 776 Daedukdae-ro, Yuseong-gu, Daejeon 305-348 (Korea, Republic of)] [Korea Astronomy and Space Science Institute, 776 Daedukdae-ro, Yuseong-gu, Daejeon 305-348 (Korea, Republic of); Collaboration: muFUN Collaboration; MOA Collaboration; OGLE Collaboration; MiNDSTEp Consortium; RoboNet Collaboration; PLANET Collaboration; and others

2013-02-15

8

Quiescent and Flaring Structure in RS Canum Venaticorum Stars  

NASA Astrophysics Data System (ADS)

Four of the most active RS CVn stars (V711 Tau, II Peg, ? Gem, and UX Ari) have been observed for a total of 3 Ms with the Extreme Ultraviolet Explorer satellite (EUVE) between 1992 and 2000 January. Flaring and quiescent states of extreme ultraviolet spectra (??70-740) and light curves (??75-175) have been analyzed to provide emission measure distributions (EMD) for these systems in the range logTe(K)~5.6-7.4, based principally on iron lines. Flux measurements obtained with IUE and the Orbiting and Retrievable Far and Extreme Ultraviolet Spectrometer (ORFEUS) complete the EMD in the lower temperature range [logTe(K)~4.0-5.6]. Frequent flaring activity has been found in the systems, including an increase during the rise phase by a factor of ~9 in the flux of ? Gem, the largest flare enhancement observed with EUVE. Analyses of the EUVE emission in the active single star AB Dor and the low-rotation giant star ? Cet are also included. The EMDs are remarkably similar among all the stars, showing a narrow enhancement or ``bump'' around logTe(K)~6.9. These narrow bumps are apparently unrelated to rotation rate, spectral type, binarity, or evolutionary stage. Significant material is found at logTe(K)>~7.0 for the most active stars. Modulation of the EUV flux outside of flaring occurs in four of the stars (? Gem, V711 Tau, UX Ari, AB Dor). The electron density ranges between Ne~1012 and ~1013 cm-3, measured at logTe(K)~7.0, and may reach higher values during flares. These densities and EMD values imply small scale sizes for emitting regions.

Sanz-Forcada, J.; Brickhouse, N. S.; Dupree, A. K.

2002-05-01

9

Starspots as the cause of the intrinsic light variations in RS Canum Venaticorum type stars  

NASA Technical Reports Server (NTRS)

A starspot model is proposed to interpret the light curves of three RS CVn type binary systems. Two of the systems are RS CVn and SZ Psc, which are detached, while the third system, RT Lac, is semidetached. Solar activity and the surface activity of the RS CVn type stars are compared. It is found that the spot model permits the detailed fitting of both the out-of-eclipse complications and the distorted shapes of the secondary eclipses in the light curves of these stars.

Eaton, J. A.; Hall, D. S.

1979-01-01

10

Possible magnetic activity cycles in two solar-type overcontact binary stars: AD Cnc and FG Hya  

NASA Astrophysics Data System (ADS)

W UMa-type binary stars are overcontact systems where both components are filling the critical Roche lobes and sharing a common convictive envelope (CCE). This type of binaries offers a good chance to study the effects of the CCE on solar-type magnetic activity. Recently, two solar-type overcontact binaries, AD Cnc (Sp.=K0; P=0.2827 days) and FG Hya (Sp.=G0; P=0.3278 days), have been monitored for several years photometrically with the 1.0-m telescope in Yunnan Observatory. The light levels at both minima and both maxima in the light curves were found to be variable. An orbital period analysis of the two systems were done based on our new determined times of light minimum combined with the others compiled from the literature. After long-term period changes were removed, double cyclic period changes were discovered for the two binaries. The light curves of those sample stars have been analysed with the new version of the W-D method and the properties of dark spot on the photospheric surface were determined. The main results are as following. (1) For FG Hya, we found that both the orbital period and the depth of the primary minimum show a cyclic change with a period of 36.4 years and in the same phase. The variation of the light curve, the spotted primary component and the connection between the period change and the depth of the primary minimum all indicate that the G0-type primary component display solar-type magnetic activity cycle with a period of 36.4 years. (2) The long-term evolution of dark spot on the photospheric surface of the primary component is presented based on the analysis of the variation of the light curves. It is found that the dark spot activity may have a 17-year cycle, which is close to the period of one cyclic component of the period variations (16.2 years). This suggests that the primary component (K0-type star) may have a 17-year magnetic activity cycle.

Qian, S.-B.; Soonthornthum, B.; Yuan, J.-Z.; He, J.-J.; Zhu, L. Y.

2006-08-01

11

Optical Flaring on Rs-Canum Stars - the Case of II-Pegasi in 1992SEP  

NASA Astrophysics Data System (ADS)

Recent observational results by Mathioudakis et al. have suggested that optical Uband flares are a frequent occurrence on the RS CVn star, II Peg. We present U-band monitoring of II Peg in 1992 September which failed to show any evidence of flaring to very low limits. We show that these data are inconsistent with the flaring rates reported earlier and suggest that either II Peg was in a state of low flare activity in 1992, or that it was unusually active at the time of Mathioudakis et al.'s observations. Key words: stars: activity - binaries: close - stars: flare - stars: individual: II Peg - stars: late-type.

Byrne, P. B.; Lanzafame, A. C.; Sarro, L. M.; Ryans, R.

1994-09-01

12

CNC Router Fundamentals Orientation  

NSDL National Science Digital Library

These zipped documents from MatEd provide information on designing a course on CNC Router Fundamentals Orientation. At the end of the course, students will be able to identify manufactured projects or products that are compatible for production on CNC routers, operate a Techno brand CNC router, and have proposed a project to reinforce these concepts. The documents include a draft syllabus, contact information for the author of the course, a sample new course proposal form, and a course outline.

Kraft, Patrick

2012-10-23

13

CNC Programming I.  

ERIC Educational Resources Information Center

This document contains five units for a course in computer numerical control (CNC) for computer-aided manufacturing. It is intended to familiarize students with the principles and techniques necessary to create proper CNC programs manually. Each unit consists of an introduction, instructional objectives, learning materials, learning activities,…

Casey, Joe

14

CNC router modernization  

E-print Network

A large-format CNC router has been stored in the Pappalardo Laboratory wood shop for several years in an unusable state. A need assessment determined that it would be cost effective to bring the router online for use in ...

Doody, Aaron L. (Aaron Lee)

2007-01-01

15

CAD/CAM/CNC.  

ERIC Educational Resources Information Center

Includes "Quick Start CNC (computer numerical control) with a Vacuum Filter and Laminated Plastic" (Domermuth); "School and Industry Cooperate for Mutual Benefit" (Buckler); and "CAD (computer-assisted drafting) Careers--What Professionals Have to Say" (Skinner). (JOW)

Domermuth, Dave; And Others

1996-01-01

16

The dusty AGB star RS CrB: first mid-infrared interferometric observations with the Keck telescopes  

NASA Technical Reports Server (NTRS)

We report interferometric observations of the semiregular variable star RS CrB, a red giant with strong silicate emission features. The data were among the first long-baseline mid-infrared stellar fringes obtained between the Keck telescopes, using parts of the new nulling beam combiner.

Mennesson, B.; Koresko, C.; Creech-Eakman, M. J.; Serabyn, E.; Colavita, M. M; Akeson, R.; Appleby, E.; Bell, J.; Booth, A.; Crawford, S.; Dahl, W.; Fanson, J.; Felizardo, C.; Garcia, J.; Gathright, J.; Herstein, J.; Hovland, E.; Hrynevych, M.; Johansson, E.; Le Mignant, D.; Ligon, R.; Millan-Gabet, R.; Moore, J.; Neyman, C.; Palmer, D.

2005-01-01

17

The chromosphere of II Pegasi: multi-line modelling of an RS Canum Venaticorum star  

NASA Astrophysics Data System (ADS)

We present the first simultaneous multi-line fitting of a semi-empirical atmospheric model with a chromosphere and transition region to the H I and Ca II spectra of an RS CVn star (II Peg). The static component of the H? emission core, the line profile of H? , the apparent absence of H? and Hdelta , and the emission core profiles of Ca II K and two of the Ca II IR(3) lines are all approximately fitted by a static 1D model with the following properties: log m at the onset of the transition region is ~ -2.85, and a 6000 K plateau in the upper chromosphere that spans about a decade in log m. In particular, the model is able to reproduce the unusually steep Balmer decrement (compared to the dMe stars), in which H? is strongly in emission and H? is in absorption, without recourse to extra-atmospheric material. The Ca II IR(3) lines are best fit by a model in which T_min is cooler by 300 K and shallower by over half a decade in log m than that which best fits the optical lines. The emergent flux in the IR(3) line cores arises from the T_min region, whereas the other diagnostics arise from layers well above T_min, and it is postulated that this may be the cause of the discrepancy. There has very recently been evidence from other investigators that the metallicity of II Peg may be sub-solar, and we find that models with [{A/ H}]=-0.4 provide a somewhat better fit to all the lines considered.

Short, C. I.; Byrne, P. B.; Panagi, P. M.

1998-10-01

18

S 10947 Aql = RX J2009.8+1557: A probable RS CVn star which sometimes stops its eclipses  

E-print Network

We report the discovery of a new variable star, called S 10947 Aql, as the likely optical counterpart of RX J2009.8+1557. The optical variability pattern as well as the detected X-ray emission suggest that it is a chromospherically active binary of the RS Canum Venaticorum type. We discovered an occasional disappearance of the eclipsing minima as well as large variations in the eclipse amplitude. We discuss possible causes of this peculiarity.

G. A. Richter; J. Greiner

2000-08-25

19

Rotational modulation and flares on RS Canum Venaticorum and BY Draconis stars. 18: Coordinated VLA, ROSAT, and IUE observations of RS CVn binaries  

NASA Technical Reports Server (NTRS)

As part of a coordinated program of multi-wavelength observations of RS CVn close binary systems, we observed 15 systems with the Very Large Array (VLA) and 10 systems with IUE, simultaneously or nearly simultaneously with the ROSAT All Sky Survey observations of these stars. Of the 22 systems observed with ROSAT, three were observed both by IUE and the VLA. Radio observations were made at 3.6, 6 and 20 cm. Of the 15 observed RS CVn systems, we detected 11 with greater than 4 sigma confidence at one or more wavelengths. The IUE observations were made within the RIASS (ROSAT-IUE All Sky Survey) program. We present the results of the VLA observations, along with the corresponding subsets of the ROSAT Position Sensitive Proportional Counter (PSPC) X-ray and Wide Field Camera (WFC) XUV survey, and RIASS IUE observations. We obtained an extended VLA/IUE/ROSAT simultaneous coverage of one system, TY Pyx, covering more than one orbital period. These observations reveal that the quiescent radio flux of TY Pyx is relatively constant over time scales of up to 7 hours, but that it did change by a factor of 3 over 24 hours, probably due to a flare on 1990 Nov. 12. The UV, XUV and X-ray fluxes do not show large day-to-day or phase-related variability. The observation of the decay phase of a radio flare on EI Eri, with no accompanying X-ray or XUV flare, suggests that the lack of a strong correlation between X-ray and radio flares previously noted for dMe flare stars holds for RS CVn systems as well. We suggest that the radio flare may have been due to a coherent emission process such as electron cyclotron emission. The simultaneous measurements presented here provide a unique test of the general correlation between radio and soft X-ray luminosities, L(sub radio) approximately L(sub x exp m) (Drake et al. 1989) with a power-law slope close to unity, which was previously derived using data obtained years apart. Our derived slopes are consistent with and thus support the general correlations between coronal and chromospheric/transition region emissions previously derived from nonsimultaneous measurements of a much larger sample of these variable sources. However, the importance of simultaneous measurements for accurate energy balance calculations is stressed.

Fox, David C.; Linsky, Jeffrey L.; Veale, Anthony; Dempsey, Robert C.; Brown, Alex; Neff, James E.; Pagano, Isabella; Rodono, Marcello; Bromage, Gordon E.; Kuerster, Martin

1994-01-01

20

The RS CVn Binary HD 155555: A Comparative Study of the Atmospheres for the Two Component Stars  

NASA Technical Reports Server (NTRS)

We present GHRS/HST observations of the RS CVn binary system HD 155555. Several key UV emission lines (Fe XXI, Si IV, O V, C IV) have been analyzed to provide information about the heating rate throughout the atmosphere from the chromosphere to the corona. We show that both the G and K components reveal features of a chromosphere, transition region and corona. The emission measure distribution as a function of temperature for both components is derived and compared with the RS Cvn system, HR 1099, and the Sun. The transition region and coronal lines of both stars show nonthermal broadenings of approx. 20-30 km/s. Possible physical implications for coronal heating mechanisms are discussed.

Airapetian, V. S.; Dempsey, R. C.

1997-01-01

21

X-ray-selected candidates for the RS CVn and W UMa classes of binary stars  

NASA Technical Reports Server (NTRS)

X-ray luminosity, spectral type, radial-velocity variation, rotationally broadened line profile, and Ca II H and K line emission data are used to identify 12 new candidates for the RS CVn class and seven new candidates for the W UMa class from spectroscopic binaries which are contained in the Einstein Extended Medium Sensitivity Survey. Under the assumption that the candidates are genuine members of each class, local space density estimates of 4.47 + or - 1.19 x 10 to the -4th/cu pc for RS CVn binaries and 8.47 + or - 3.00 x 10 to the -5th/cu pc for W UMa binaries are found. Although the density estimate for the W UMa binaries is shown to be consistent with previous estimates obtained from optically selected samples, the estimate for the RS CVn binaries is more than an order of magnitude greater than previously determined space densities.

Fleming, Thomas A.; Gioia, Isabella M.; Maccacaro, Tommaso

1989-01-01

22

Characterization of the Transiting Super-Earth 55 Cnc e  

NASA Astrophysics Data System (ADS)

The transiting nature of 55 Cnc e has been recently unveiled independently by the MOST satellite in the visible (Winn et al. 2011) and Warm Spitzer in the infrared (Demory et al. 2011). 55 Cnc e is the only transiting super-Earth orbiting a naked eye star, which makes this planet a true Rosetta stone in the field of low-mass exoplanets. We will present new follow-up observations scheduled during Summer 2011 that will provide better constraints on the internal structure and immediate environment of this intriguing super-Earth.

Demory, Brice-Olivier; Gillon, M.; Deming, D.; Seager, S.

2011-09-01

23

Planetpol polarimetry of the exoplanet systems 55Cnc and tauBoo  

Microsoft Academic Search

We present very sensitive polarimetry of 55Cnc and tauBoo in an attempt to detect the partially polarized reflected light from the planets orbiting these two stars. 55Cnc is orbited by a hot Neptune planet (55Cnce) at 0.038au, a hot Jupiter planet (55Cncb) at 0.11au and at least three more distant planets. The polarization of this system is very stable, showing

P. W. Lucas; J. H. Hough; J. A. Bailey; M. Tamura; E. Hirst; D. Harrison

2009-01-01

24

CNC Preparation Meets Manufacturing Opportunity  

ERIC Educational Resources Information Center

This article features the machining technology program at Cape Fear Community College (CFCC) of Wilmington, North Carolina. North Carolina's Cape Fear Community College is working to meet diverse industry needs through its CNC training. The school's program has gained the attention of the local manufacturing community and students when it shifted…

Cassola, Joel

2006-01-01

25

CNC electrical discharge machining centers  

SciTech Connect

Computer numerical control (CNC) electrical discharge machining (EDM) centers were investigated to evaluate the application and cost effectiveness of establishing this capability at Allied-Signal Inc., Kansas City Division (KCD). In line with this investigation, metal samples were designed, prepared, and machined on an existing 15-year-old EDM machine and on two current technology CNC EDM machining centers at outside vendors. The results were recorded and evaluated. The study revealed that CNC EDM centers are a capability that should be established at KCD. From the information gained, a machine specification was written and a shop was purchased and installed in the Engineering Shop. The older machine was exchanged for a new model. Additional machines were installed in the Tool Design and Fabrication and Precision Microfinishing departments. The Engineering Shop machine will be principally used for the following purposes: producing deep cavities in small corner radii, machining simulated casting models, machining difficult-to-machine materials, and polishing difficult-to-hand polish mold cavities. 2 refs., 18 figs., 3 tabs.

Jaggars, S.R.

1991-10-01

26

Rotational Brightness Modulation and Starspots on the RS CVn-type Stars IN Com, IL Com, UX Ari, and V711 Tau  

NASA Astrophysics Data System (ADS)

UBVRI photometric observations and models of spotting are presented for four noneclipsing RS CVn systems: IN Com (G5III/IV), IL Com (F8V+F8V), UX Ari (K01V+G5V), and V711 Tau (K1IV+G5V). A low amplitude variability caused by cold (T=1700K)spots which can occupy up to 19% of the star''s surface is confirmed for the little-studied star IL Com. Long-term light curves are constructed and the stellar magnitudes and color indices of the unspotted photospheres are estimated for IN com, UX Ari, and V711 Tau. It is shown that UX Ari becomes bluer with decreasing brightness, so its variability cannot be fully explained in terms of cold spots. Models of spotting on In Com and V711 Tau are constructed from the full set of available photometric observations. The spots on both of these variables lie at middle latitudes and occupy up to 22% (In Com) and 33% (V711 Tau) of the stars'' surfaces. Both stars manifest a tendency for the width of the spots to decrease as their area increases. This is a crude analog of the Maunder butterflies. These stars experience cyclical spot activity and have a differential rotation of the type found on the sun.

Alekseev, I. Yu.; Kozhevnikova, A. V.

2004-10-01

27

The photosphere and chromosphere of the RS Canum Venaticorum star, II Pegasi. II. A multi-wavelength campaign in August/September 1992  

NASA Astrophysics Data System (ADS)

We describe multi-wavelength, simultaneous observations of the RS CVn star, II Pegasi, most of which were obtained during the first three weeks of September 1992. These observations were made using optical and infra-red broad-band photometry, ultraviolet and optical spectroscopy and microwave monitoring. We have detected photospheric spots and chromospheric flares, as well as deriving a description of mean conditions in the quiet chromosphere. One of the flares, observed in optical photometry and ultraviolet spectroscopy is one of the most energetic ever observed on this star. We demonstrate that in its ``quiescent'' state II Peg is continually variable in most of its chromospheric emissions, as well as in its coronal output.

Byrne, P. B.; Abdul Aziz, H.; Amado, P. J.; Arevalo, M. J.; Avgoloupis, S.; Doyle, J. G.; Eibe, M. T.; Elliott, K. H.; Jeffries, R. D.; Lanzafame, A. C.; Lazaro, C.; Murphy, H. M.; Neff, J. E.; Panov, K. P.; Sarro, L. M.; Seiradakis, J. H.; Spencer, R. E.

1998-02-01

28

The Orbital Architecture of 55 Cnc: An Orbital Resonance, Jupiter Analog, and Transiting Super-Earth  

NASA Astrophysics Data System (ADS)

55 Cnc is the only naked eye star with a known transiting planet (Winn et al. 2011) and one of a few systems with five known planets characterized via Doppler methods. The planets span a wide range of masses and orbital periods. We investigate the orbital architecture, focusing on two of the giant planets near 3:1 mean-motion resonance and the potential impact on the dynamical effects on the other planets. To quantify the uncertainty in the orbital parameters of the 55 Cnc system requires exploring a high-dimensional ( 35) parameter space and using self-consistent N-body integrations, both of which are computationally demanding. To surmount these challenges, we apply a differential evolution Markov chain Monte Carlo algorithm to characterize the orbital properties and masses. We present these results and discuss the implications on the dynamical evolution of the 55 Cnc system.

Nelson, Benjamin E.; Payne, M.; Ford, E.; Wright, J.

2011-09-01

29

Improving Energy Efficiency in CNC Machining  

NASA Astrophysics Data System (ADS)

We present our work on analyzing and improving the energy efficiency of multi-axis CNC milling process. Due to the differences in energy consumption behavior, we treat 3- and 5-axis CNC machines separately in our work. For 3-axis CNC machines, we first propose an energy model that estimates the energy requirement for machining a component on a specified 3-axis CNC milling machine. Our model makes machine-specific predictions of energy requirements while also considering the geometric aspects of the machining toolpath. Our model - and the associated software tool - facilitate direct comparison of various alternative toolpath strategies based on their energy-consumption performance. Further, we identify key factors in toolpath planning that affect energy consumption in CNC machining. We then use this knowledge to propose and demonstrate a novel toolpath planning strategy that may be used to generate new toolpaths that are inherently energy-efficient, inspired by research on digital micrography -- a form of computational art. For 5-axis CNC machines, the process planning problem consists of several sub-problems that researchers have traditionally solved separately to obtain an approximate solution. After illustrating the need to solve all sub-problems simultaneously for a truly optimal solution, we propose a unified formulation based on configuration space theory. We apply our formulation to solve a problem variant that retains key characteristics of the full problem but has lower dimensionality, allowing visualization in 2D. Given the complexity of the full 5-axis toolpath planning problem, our unified formulation represents an important step towards obtaining a truly optimal solution. With this work on the two types of CNC machines, we demonstrate that without changing the current infrastructure or business practices, machine-specific, geometry-based, customized toolpath planning can save energy in CNC machining.

Pavanaskar, Sushrut S.

30

A Benchmark Infrared Characterisation of the Super-Earth 55 Cnc e  

NASA Astrophysics Data System (ADS)

The Kepler mission and radial-velocity surveys have revealed that super-Earth exoplanets are not only ubiquitous in our galaxy but also very diverse in terms of physical properties. However, very little is known about their nature because of the paucity of suitable targets amenable to detailed characterization. Two super-Earths, GJ1214b and 55Cnc e, orbit stars that are bright enough to enable detailed atmospheric and interior composition studies, which are crucial to improve our understanding of this class of exoplanets. As of today, 55Cnc e is the only super Earth amenable to occultation and phase curve infrared photometry, as well as a prime target to understand the nature of highly irradiated super Earths. In the past two years, Spitzer observations of 55 Cnc e resulted in photometric lightcurves of unprecedented quality, thanks to the brightness of its host star. We propose an observing program of 180 hours to pursue this effort. Our main goal is to determine whether 55 Cnc e harbors an atmosphere or not. We propose to obtain four orbital phase curves of 55 Cnc e at 4.5 microns and four other at 3.6 microns. Our observations will unambiguously determine whether 55 Cnc e is volatile-poor or volatile-rich. We will also measure for the first time the 3D climate patterns in a super-Earth atmosphere. Finally, our program will deliver precise transit, occultation and phase-curve photometry that will constitute an important legacy regarding the characterization of a super-Earth exoplanet, well in advance of JWST.

Demory, Brice-Olivier; Kataria, Tiffany; Lewis, Nikole; Krick, Jessica; Queloz, Didier; Gillon, Michael; Stamenkovic, Vlada; Madhusudhan, Nikku; Fortney, Jonathan; de Wit, Julien; Kane, Stephen

2014-12-01

31

An empirical research for CNC technology implementation in manufacturing SMEs  

Microsoft Academic Search

The aim of this research is to investigate whether CNC technology affects the firm performance and to determine the manufacturing\\u000a parameters and competitive priorities that are affected by the adoption of CNC technology. In order to understand the effect\\u000a of CNC adoption on firm performance, CNC user and non-user firms were investigated statistically to determine any significant\\u000a difference between them.

Tufan Koc; Erhan Bozdag

2007-01-01

32

MULTIBAND PHOTOMETRIC AND SPECTROSCOPIC ANALYSIS OF HV Cnc  

SciTech Connect

In this paper, radial velocity and VI- and JHK{sub S} - (Two Micron All Sky Survey) band photometric data of the detached system HV Cnc have been analyzed. The primary component of HV Cnc, which is a member of the M67 cluster, is suspected to be either a blue straggler or turn-off star. The system is a single-lined spectroscopic binary and its light curve shows a total eclipse. Spectroscopic observations of the system revealed the third component, which shows contribution to the total light of the system. Light curve and radial velocity data have been analyzed using the Wilson-Devinney (W-D) code and JHK{sub S} filter definitions computed for the W-D code in this work. Our analysis shows that the mass and radius of the primary and secondary components are 1.31 M {sub ?}, 0.52 M {sub ?}, 1.87 R {sub ?}, and 0.48 R {sub ?}, respectively. All results are compared with previously published literature values and discussed.

Gökay, G.; Gürol, B.; Derman, E., E-mail: ggokay@science.ankara.edu.tr [Astronomy and Space Sciences Department, Faculty of Science, Ankara University, 06100 Tando?an, Ankara (Turkey)

2013-11-01

33

An intelligent CNC machine control system architecture  

SciTech Connect

Intelligent, agile manufacturing relies on automated programming of digitally controlled processes. Currently, processes such as Computer Numerically Controlled (CNC) machining are difficult to automate because of highly restrictive controllers and poor software environments. It is also difficult to utilize sensors and process models for adaptive control, or to integrate machining processes with other tasks within a factory floor setting. As part of a Laboratory Directed Research and Development (LDRD) program, a CNC machine control system architecture based on object-oriented design and graphical programming has been developed to address some of these problems and to demonstrate automated agile machining applications using platform-independent software.

Miller, D.J.; Loucks, C.S.

1996-10-01

34

BD Andromedae: A New Short-period RS CVn Eclipsing Binary Star with a Distant Tertiary Body in a Highly Eccentric Orbit  

NASA Astrophysics Data System (ADS)

A photometric study of BD And was made through the analysis of two sets of new BVR light curves. The light curves with migrating photometric waves outside eclipse show that BD And is a short-period RS CVn-type binary star. The analysis of all available timings reveals that the orbital period has varied in a strictly cyclical way with a period of 9.2 yr. The periodic variation most likely arises from the light-time effect due to a tertiary moving in a highly elliptical orbit (e 3 = 0.76). The Applegate mechanism could not operate properly in the eclipsing pair. The light curves were modeled with two large spots on the hotter star and a large third light amounting to about 14% of the total systemic light. BD And is a triple system: a detached binary system consisting of two nearly equal solar-type stars with an active primary star and a G6-G7 tertiary dwarf. The absolute dimensions of the eclipsing pair and tertiary components were determined. The three components with a mean age of about 5.8 Gyr are located at midpositions in main-sequence bands. The radius of the secondary is about 17% larger than that deduced from stellar models. The orbital and radiometric characteristics of the tertiary are intensively investigated. One important feature is that the mutual inclination between two orbits is larger than 60°, implying that Kozai cycles had occurred very efficiently in the past. The possible past and future evolutions of the BD And system, driven by KCTF and MBTF, are also discussed.

Kim, Chun-Hwey; Song, Mi-Hwa; Yoon, Jo-Na; Han, Wonyong; Jeong, Min-Ji

2014-06-01

35

The multi-scale environment of RS Cancri from CO and H I observations  

NASA Astrophysics Data System (ADS)

We present a detailed study of the circumstellar gas distribution and kinematics of the semi-regular variable star RS Cnc on spatial scales ranging from ~1'' (~150 AU) to ~6' (~0.25 pc). Our study utilizes new CO1-0 data from the Plateau de Bure Interferometer and new H i 21 cm line observations from the Jansky Very Large Array (JVLA), in combination with previous observations. New modeling of CO1-0 and CO2-1 imaging observations leads to a revised characterization of RS Cnc's previously identified axisymmetric molecular outflow. Rather than a simple disk-outflow picture, we find that a gradient in velocity as a function of latitude is needed to fit the spatially resolved spectra, and in our preferred model, the density and the velocity vary smoothly from the equatorial plane to the polar axis. In terms of density, the source appears quasi-spherical, whereas in terms of velocity the source is axisymmetric with a low expansion velocity in the equatorial plane and faster outflows in the polar directions. The flux of matter is also larger in the polar directions than in the equatorial plane. An implication of our model is that the stellar wind is still accelerated at radii larger than a few hundred AU, well beyond the radius where the terminal velocity is thought to be reached in an asymptotic giant branch star. The JVLA H i data show the previously detected head-tail morphology, and also supply additional details about the atomic gas distribution and kinematics. We confirm that the head seen in H i is elongated in a direction consistent with the polar axis of the molecular outflow, suggesting that we are tracing an extension of the molecular outflow well beyond the molecular dissociation radius (up to ~0.05 pc). The 6'-long H i tail is oriented at a PA of 305°, consistent with the space motion of the star. The tail is resolved into several clumps that may result from hydrodynamic effects linked to the interaction with the local interstellar medium. We measure a total mass of atomic hydrogen MHI ? 0.0055 M? and estimate a lower limit to the timescale for the formation of the tail to be ~6.4 × 104 years. Based on observations carried out with the IRAM Plateau de Bure Interferometer and the IRAM 30 m telescope. IRAM is supported by INSU/CNRS (France), MPG (Germany) and IGN (Spain).

Hoai, D. T.; Matthews, L. D.; Winters, J. M.; Nhung, P. T.; Gérard, E.; Libert, Y.; Le Bertre, T.

2014-05-01

36

Design of five-axis CNC based on Linux  

Microsoft Academic Search

For complex parts of high speed, high precision machining demands, five -axis CNC system is studied, on the analysis of application of the embedded technology in CNC system, put forward a kind of new type of five-axis CNC system. The design utilizes an embedded multi-processor ideology to be S3C2410 processor as hardware core and motion control chips MCX314 as Secondary

Wang Changlei; Cao Shukun; Zhang Qianqian; Sui Zhiming; Yang Shangwei

2011-01-01

37

The photosphere and chromosphere of the RS Canum Venaticorum star, II Pegasi I. Spots and chromospheric emission in 1991.  

NASA Astrophysics Data System (ADS)

We report on high-resolution spectroscopy of the RSCVn binary IIPeg, along with contemporaneous UBV(RI)_KC_ photometry, including partly simultaneous U-band flare monitoring, during the third quarter of 1991. The spectroscopy was taken at two epochs separated by more than 6(1)/(2) weeks or seven rotations of IIPeg. At the first epoch we have observed the three chromospheric lines, H?, H? and HeID_3_, over a single rotation and at the second epoch we observed almost the entire visible region, for a substantial fraction of one rotation, including H?-H? and CaIIH. Our photometric results show that there was an unusually complicated spot distribution at this epoch, with at least three centres of activity discernable. We demonstrate, for the first time on a spotted late-type star, that these centres of spot activity have significantly different mean temperatures from one another. Furthermore, our derived spot temperatures are markedly lower than those previously derived from such multicolour photometry and more similar to those derived spectroscopically. Using multiple repeat exposures on each spectral line within each night, we are confident that we have derived a mean, non-flaring spectrum at each observational phase. Furthermore, the line flux variations at the two epochs repeat very well, suggesting that the mean global chromospheric structures are stable on a 1(1)/(2) months time scale. We discuss the implications of the mean spectra for the non-flaring atmosphere of IIPeg and conclude that, in the region of formation of the H? line, velocity fields are required to account for the line profile. These results suggest upward motions of the deep chromosphere with a less dramatic downflow in the high chromosphere. We examine the variation of the chromospheric line fluxes as a function of spot visibility and conclude that there is only a very loose spatial correlation of chromsopheric heating with spots. The motions suggested from the H? profile variations appear to be spot-associated.

Byrne, P. B.; Panagi, P. M.; Lanzafame, A. C.; Avgoloupis, S.; Huenemoerder, D. P.; Kilkenny, D.; Marang, F.; Panov, K. P.; Roberts, G.; Seiradakis, J. H.; van Wyk, F.

1995-07-01

38

Planetpol polarimetry of the exoplanet systems 55Cnc and ?Boo  

NASA Astrophysics Data System (ADS)

We present very sensitive polarimetry of 55Cnc and ?Boo in an attempt to detect the partially polarized reflected light from the planets orbiting these two stars. 55Cnc is orbited by a hot Neptune planet (55Cnce) at 0.038au, a hot Jupiter planet (55Cncb) at 0.11au and at least three more distant planets. The polarization of this system is very stable, showing no sign of the periodic variations that would be expected if a short-period planet were detected. The measured standard deviation of the nightly averaged Stokes Q/I and U/I parameters is 2.2 × 10-6. We derive upper limits on the geometric albedo, AG, and planetary radius using Monte Carlo multiple scattering simulations of a simple model atmosphere. We assume Rayleigh-like scattering and polarization behaviour (scaled by the maximum polarization, pm, at 90°) and pressure insensitive extinction. Atmospheres in which multiple scattering plays only a small role have an almost linear relation between polarization and AG. In this case, the 4? upper limit is AG < 0.13(R/1.2RJup)-2p-1m for 55Cnce. This is most easily explained if 55Cnce is relatively small, like GJ436b, and therefore not a pure H-He planet. The data do not provide a useful upper limit for 55Cncb. ?Boo is orbited by an unusually massive hot Jupiter planet. The data show a standard deviation in the night-to-night average Stokes Q/I and U/I polarization parameters of 5.1 × 10-6. The 4? upper limit is AG < 0.37(R/1.2RJup)-2p-1m for ?Boob, adopting the fairly well established orbital inclination i ~ 40°. This extends the similar upper limits reported previously for this planet to longer wavelengths. The fact that the ?Boo data show more scatter, despite the smaller photon noise for this bright star, may be due to the spot activity detected photometrically by the Microvariability & Oscillations of Stars (MOST) satellite. These results contrast markedly with the recent claim of a 3? detection of a periodic polarization signal from HD189733 with amplitude P = 2 × 10-4, attributed to the planet HD189733b. Based on observations made with the William Herschel Telescope operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatory del Roque de los Muchachos of the Instituto de Astrofisica de Canarias. E-mail: p.w.lucas@herts.ac.uk

Lucas, P. W.; Hough, J. H.; Bailey, J. A.; Tamura, M.; Hirst, E.; Harrison, D.

2009-02-01

39

Advanced CNC Programming (EZ-CAM). 439-366.  

ERIC Educational Resources Information Center

This document contains two units for an advanced course in computer numerical control (CNC) for computer-aided manufacturing. It is intended to familiarize students with the principles and techniques necessary to create proper CNC programs using computer software. Each unit consists of an introduction, instructional objectives, learning materials,…

Casey, Joe

40

Study of Accuracy of CNC Machine Tools  

NSDL National Science Digital Library

The dimensional accuracies as well as surface finishes of parts produced by a CNC machine tool are strongly dependent on the motion accuracy of each axis of the machine. The overall accuracy of the machine tool is decided by the mechanical characteristics of the machine as well as the characteristics if the control system driving the individual axes. A CNC Machine is programmed to travel along a predetermined or contour, and any deviation from the programmed path is referred as the contouring error. A typical test that is used is a circular test in which the machine is programmed to travel along a circle, and the difference between the programmed path and the measured actual path is compared. The purpose of this study is to identify the various contributors to this contouring error, and in particular estimate the error due to stick slip motion using analytical techniques. It is planned to measure the errors experimentally making use of capacitance probes. The study is intended to develop an appreciation for the sources of different errors produced in a machine tool and as such forms a module in a typical semester long class devoted to manufacturing processes.

Chattopadhyay, Sonnath

41

A hybrid type small 5-axis CNC milling machine  

E-print Network

5-axis CNC milling machines are important in a number of industries ranging from aerospace to consumer-die-mold machining because they can deliver high machining accuracy with a spindle tilting capacity. Most of these ...

Son, Seung-Kil, 1964-

2002-01-01

42

Design and Analysis of a Modular Cnc System  

Microsoft Academic Search

\\u000a Recent focus of manufacturing research has been in the development of unmanned machining systems. Modular Computer Numerical\\u000a Control (CNC) units, which control and monitor many tightly coupled machining tasks, are required. This article describes\\u000a the detailed engineering design and analysis of a modular, research CNC system for a milling machine. Continuous and discrete\\u000a transfer functions of a feed drive servo

Y. Altintas

43

Ground-based Transit Observations of the Super-Earth 55 Cnc e  

NASA Astrophysics Data System (ADS)

We report the first ground-based detections of the shallow transit of the super-Earth exoplanet 55 Cnc e using a 2 m class telescope. Using differential spectrophotometry, we observed one transit in 2013 and another in 2014, with average spectral resolutions of ~700 and ~250, spanning the Johnson BVR photometric bands. We find a white light planet-to-star radius ratio of 0.0190-0.0027+0.0023 from the 2013 observations and 0.0200-0.0018+0.0017 from the 2014 observations. The two data sets combined result in a radius ratio of 0.0198-0.0014+0.0013. These values are all in agreement with previous space-based results. Scintillation noise in the data prevents us from placing strong constraints on the presence of an extended hydrogen-rich atmosphere. Nevertheless, our detections of 55 Cnc e in transit demonstrate that moderate-sized telescopes on the ground will be capable of routine follow-up observations of super-Earth candidates discovered by the Transiting Exoplanet Survey Satellite around bright stars. We expect it also will be possible to place constraints on the atmospheric characteristics of those planets by devising observational strategies to minimize scintillation noise.

de Mooij, E. J. W.; López-Morales, M.; Karjalainen, R.; Hrudkova, M.; Jayawardhana, Ray

2014-12-01

44

Far Ultraviolet Spectroscopy of Three Long Period Nova-Like Variables, V363 Aur, AC Cnc and RZ Gru  

NASA Astrophysics Data System (ADS)

We have selected three nova-like variables: V363 Aur, RZ Gru and AC Cnc, all of which are UX UMa types, having similar orbital periods well beyond the 3 to 4 hour range where most nova-likes are found. All should have very similar secondary stars given the fact that they their physical parameters are so similar. V363 Aur is a bona fide SW Sex star, and AC Cnc is a probable one, while RZ Gru is not a member of the SW Sex subclass. Our objective is to carry out the first synthetic spectral analysis of far ultraviolet spectra of the three systems using state-of-the-art models both of accretion disks and photospheres. Therefore we shall compare the distances we obtain from the best fitting synthetic spectral models to other distance estimates in the literature. We present model-derived accretion rates and distances for all three systems. The FUV flux range of RZ Gru and V363 Aur is dominated by radiation from an optically thick, steady state, accretion but for AC Cnc, we find that a hot white dwarf accounts for 70% of the FUV flux. We compare the FUV characteristics and physical properties of these three long period nova-like systems to the properties of other nova-likes at shorter periods. This work was supported in part by NSF grant AST0807892 to Villanova University.

Bisol, Alexandra; Sion, E. M.

2011-01-01

45

Catalogue of Main Characteristics of Pulsations of 173 Semi-Regular Stars  

NASA Astrophysics Data System (ADS)

The characteristics of brightness variations of 173 semi-regular stars are tabulated: the moments and brightness of the extrema; the effective periods, amplitudes and significance obtained by using different methods: a) the periodogram analysis (harmonic least squares t) with prewhitening to determine characteristics and significance of waves with 3 periods; b) the wavelet analysis to determine characteristics of statistically significant waves; ) the "running parabola" scalegram analysis to determine the optimal filter half - width for smoothing. The characteristics may be used for more precise classification of semi-regular variables. Characteristics of the 6509 extrema of 147 stars are listed. The electronic version is available via http://ila.webjump.om. The observations for the analysis have been taken from the AFOEV and VSOLJ databases (with a duration up to 94 years) for the stars: AQ, EH, EK, RS, RU, RV, ST, TV, TY, TZ, UX, VX And; GY, PX, S, V, V844 Aql; V, Z Aqr; T Ari; AG, RS, S, UU, Z Aur; RV, RW, RX, RZ, U, V, WY Boo; T Cae; RR, RS, RY, S, ST, U Cam; RT Cap; PZ, SV, UX, V393, V465, WZ Cas; T, Y Cen; AR, RU, RW, RX, SS, TY, W Cep; T Cet; RS, RT, T, X Cnc; RR, RS, TT CrB; V, Y Cvn; AA, AF, AI, AV, AW, BC, RS, RU, RV, RW, RZ, TT, V460, W Cyg; EU, U Del; RS, RY, S, TX, UX, WZ Dra; SY, Z Eri; IS, NQ, RS, SW, TU, TV, Y Gem; DE, MZ, RR, ST, SX, UU, X Her; FF, RT, U, V, W, Y Hya; RS Lac; RY, SX Leo; RX, S Lep; U, W LMi; Y, EG, R, SZ Lyr; RV, SW, X Mon; V759 Oph; BQ, FX, GT, RT, W Ori; AF, AK, SV, TX Peg; AD, BU, DY, FZ, RS, RU, S, SU, SY, T, UZ, W, XX Per; R Pic; RT, RW, Z Psc; BM Sco; S Sct; FG Ser; X Sge; AB, TT, W, Y Tau; W Tri; RX, RY, RZ, ST,SV, V, Y, Z UMa; R, V UMi; RT, SS, SW Vir; RU Vul.

Chinarova, L. L.; Andronov, I. L.

2000-12-01

46

CNC Turning Center Advanced Operations. Computer Numerical Control Operator/Programmer. 444-332.  

ERIC Educational Resources Information Center

This student guide provides materials for a course designed to introduce the student to the operations and functions of a two-axis computer numerical control (CNC) turning center. The course consists of seven units. Unit 1 presents course expectations and syllabus, covers safety precautions, and describes the CNC turning center components, CNC

Skowronski, Steven D.; Tatum, Kenneth

47

Superhumps and Reflares in the WZ Sge-Type Dwarf Nova EG CNC  

NASA Astrophysics Data System (ADS)

EG Cnc is a dwarf nova discovered by Huruhata (1983). No outbursts had been confirmed until 1996 since its last in 1977. The long interval between outbursts and the large (~8 mag) outburst amplitude have strongly suggested that this star belongs to the rare class of WZ Sge-type dwarf novae consisting of only three secure members. Upon VSNET alert on the detection of its second historical outburst by P. Schmeer on 1996 Dec. 30, we undertook extensive CCD photometry using the Osaka Kyoiku University 51 cm telescope and the Ouda 60 cm telescope. Our observation has revealed the existence of two distinct types of superhumps just as were observed in other WZ Sge-type members, WZ Sge and AL Com. The object further showed, for the first time in the history of dwarf novae, repeated ``mini-outbursts" or reflares after its main superoutburst. We discuss from this new observational finding on the relationship between the repeated reflares in EG Cnc and the double superoutburst in AL Com, with a possible implication on the mechanism of similar ``mini-outbursts" observed in the black hole-candidate X-ray transient GRO J0422+32.

Kato, T.; Nogami, D.; Baba, H.; Masuda, S.; Matsumoto, K.

48

Optical, UV and Radio Observations of RS Canum Venaticorum  

NASA Astrophysics Data System (ADS)

Preliminary results are reported on optical, UV and radio observations of the binary system RS Canum Venaticorum carried out in March 1984, as a part of the international coordinated programme on solar-like activity in late type stars.

Catalano, S.; Rodono, M.; Linsky, J. L.; Carpenter, K.; Gibson, D.; Gary, D.; Butler, J.

49

Implementation of Additive Rapid Prototyping on Retrofit CNC Mill  

Technology Transfer Automated Retrieval System (TEKTRAN)

Freeform fabrication techniques are gaining popularity as a means of making parts. Layered additive methods are associated with rapid prototyping. Many rapid prototyping methods are commercially proprietary and may cost thousands of dollars. Using a retrofit CNC mill for layered fabrication and C...

50

Modelling and simulation of CNC machine tool feed drives  

Microsoft Academic Search

The paper presents a critical appraisal of existing methods for modelling and simulation of CNC machine tool feed drives. Their goal is the development of mathematical models which adequately replicate the dynamic behaviour of the actual machines. The advantages and disadvantages of lumped parameter models and modular approach are discussed and the suitability of mixed, hybrid, distributed-lumped modelling is emphasised.

C. Pislaru; D. G. Ford; V. Y. Moreno-Castaneda

51

Fidget with Widgets: CNC Activity Introduces the Flatbed Router  

ERIC Educational Resources Information Center

The computer numerical control (CNC) flatbed router is a powerful tool and a must-have piece of equipment for any technology education program in which students will produce a product--whether it involves Manufacturing, Materials Processing, or any of the vast array of Project Lead the Way courses. This article describes an activity--producing a…

Tryon, Daniel V.

2006-01-01

52

Rotational Modulation and Flares on Rs-Canum and By-Draconis Stars - Part Seventeen - Ultraviolet Spectroscopy and Optical Photometry of Au-Microscopii in 1986  

NASA Astrophysics Data System (ADS)

We present IUE spectroscopy and optical photometry of the active late type star AU Mic. The UV spectroscopy allow us to measure the chromospheric and transition region line fluxes. No detectable variations attributable to rotational modulation were evident in either the chromospheric lines or optical bands. We have produced an emission measure curve for the quiescent state of AU Mic, which spans a temperature range 4.0 ? log Te ? 7.6 when coupled with previous X-ray flux measurements. The quiescent radiative losses per unit surface area over the above temperature range is ?8 1O7 erg cm-2 s-1

Quin, D. A.; Doyle, J. G.; Butler, C. J.; Byrne, P. B.; Swank, J. H.

1993-05-01

53

Rotational modulation and flares on RS CVn and BY Dra-type stars. V - Exosat and IUE observations of a flare on EQ Pegasi  

NASA Technical Reports Server (NTRS)

Time-trailed UV spectra and a soft X-ray lightcurve were obtained during a flare on the binary dMe star EQ Peg AB. On the basis of solar flare Mg II surface fluxes and an about 70-percent enhancement in the disk-integrated flux during the flare on EQ Peg, it is estimated that the chromospheric flare covered about 1.5 percent of the stellar surface. The size scale is estimated to be comparable to that of a solar two-ribbon flare. This unusual flare is noted to exhibit a low-energy soft X-ray rise phase which is longer than that of most flares; it is longer than the decay phase and peaks much later than the medium energy light curve. Evidence of variable Fe II emission and variable continuum emission in select UV bands during the flare is noted.

Haisch, B. M.; Butler, C. J.; Doyle, J. G.; Rodono, M.

1987-01-01

54

CNC subaperture polishing process arrangement for microroughness minimisation  

NASA Astrophysics Data System (ADS)

The aim of this study was to determine the optimal subaperture polishing procedure for aspherical surfaces on the Optotech MCP 250 CNC machine. Due to the fact that the CNC subaperture polishing process runs along well defined paths, certain frequencies develop on the polished surface, which can be limiting for the resulting microroughness. A proper sequence of polishing steps in different tool motion control modes can minimize these frequencies and help to substantially reduce microroughness. In this context, various tool motion control modes ("Spiral spindle mode", "Spiral axis mode" and "Raster mode") in combination with different tools were tested. The resulting microroughness values were observed in the defined mid-frequency and high-frequency areas. The best results, i.e. the lowest microroughness values were obtained using a combination of the processes "Ball spiral axis mode", "FEM raster mode", "spiral spindle 2D FEM correction mode" and "AFJ spiral axis mode"

Prochaska, F.; Matousek, O.; Tomka, D.; Polak, J.; Poláková, I.

2015-01-01

55

Applications of integrated motion controllers for precise CNC machines  

Microsoft Academic Search

The error resources of precise motion control systems are basically categorized into linear and nonlinear effects. To realize\\u000a the precise motion of industrial computer numerical control (CNC) machines, this paper presents an integrated motion control\\u000a structure with modular algorithms, including both the linear control and the nonlinear compensation. In the linear control\\u000a design, this study applies three algorithms: (1) feedforward

Syh-Shiuh Yeh; Zheng-Hong Tsai; Pau-Lo Hsu

2009-01-01

56

Retrofitment of a CNC machine for hybrid layered manufacturing  

Microsoft Academic Search

Subtractive manufacturing [computer numerical controlled (CNC) machining] has high quality geometric and material properties\\u000a but is slow, costly, and infeasible in some cases. On the contrary additive manufacturing (rapid prototyping) has total automation\\u000a but compromises quality. A hybrid layered manufacturing process presented in this study combines the best features of both\\u000a these approaches. It uses arc weld deposition for building

K. P. Karunakaran; S. Suryakumar; Vishal Pushpa; Sreenathbabu Akula

2009-01-01

57

A multi-agent-based intelligent STEP-NC controller for CNC machine tools  

Microsoft Academic Search

ISO 6983 has now been considered as a bottleneck for developing next generation CNC machine tools. STEP-NC is a new interface standard between CAD\\/CAM systems and CNC machines, which not only provides an object-oriented data model for CNC with a detailed and structured data interface that incorporates feature-based programming, but also represents a data model for intelligent computer numerical controllers.

H. Lan; R. Liu; C. Zhang

2008-01-01

58

Precise Gouging-free Tool Orientations for 5-Axis CNC Machining Yong-Joon Kima  

E-print Network

Precise Gouging-free Tool Orientations for 5-Axis CNC Machining Yong-Joon Kima , Gershon Elbera-free tool paths for 5-axis CNC machining of freeform NURBS surfaces using flat-end and rounded-end (bull of the machining, while being gouge-free and possibly satisfying constraints on the tool tilt and the tool

Pottmann, Helmut

59

Implementation of CAD/CAM/CNC Curriculum Using Mastercam X Software in Technical Programs  

NSDL National Science Digital Library

One of the major contributions to the growing acceptance of Computer Numerical Control (CNC) has been the development of Computer Aided Manufacturing (CAM). A Computer Aided Manufacturing (CAM) program uses a CAD drawing, and then adds the cutting parameters to generate the CNC program. MastercamX is PC-based CAD/CAM software, which integrates the geometry, toolpath, and the G-code program together. The CAD section of the Mastercam software generates a dimensioned drawing using basic entities. The geometry file is saved as a CAD file and then turned into CNC code. The CNC code is used to machine parts on a milling machine. Mastercam software ties the CAD/CAM process together to generate a CNC program to make a part, using a machine tool.

Heidari, Farzin

2009-09-25

60

Time-optimal CNC tool paths : a mathematical model of machining  

E-print Network

Free-form surface machining is a fundamental but time-consuming process in modern manufacturing. The central question we ask in this thesis is how to reduce the time that it takes for a 5-axis CNC (Computer Numerical ...

Kim, Taejung, 1969-

2001-01-01

61

Production of multifluted drills on six-axis CNC tool-grinding machine  

Microsoft Academic Search

This paper presents a kinematic model to produce multifluted drills on a six-axis CNC tool-grinding machine. There are three special features of the proposed model. The first is the use of Denavit-Hartenberg notation to establish the ability matrix of a six-axis CNC tool-grinding machine. The second feature, the concept of a virtual hollow grinding wheel and virtual solid dresser, is

Jung-Fa Hsieh; Psang Dain Lin

2003-01-01

62

Cellulose nanocrystals (CNC) as carriers for a spirooxazine dye and its effect on photochromic efficiency.  

PubMed

Nanocrystalline cellulose (CNC) as a renewable/sustainable material, has received much attention. Herein we studied CNC as carriers for a hydrophobic spirooxazine (SO)-based dye, 1,3-dihydro-1,3,3-trimethylspiro[2H-indole-2,3'-[3H]naphtha[2,1-b][1,4]oxazine], which may have potential applications in reversible memory photo-devices, textiles, photo-sensitive paper coatings, and inkjet printing inks. Due to the high cost and water-insolubility of this dye, it is desirable to improve its coloration efficiency and water-dispersibility. The experimental approach was to use CNC as carriers for the SO dye, thus obtaining a stable photochromic dye in aqueous systems. Transmission electron microscope (TEM) observation confirmed that the SO dye adsorbed on the surface of the CNC, which functioned as carriers for the photochromic dye. An impregnation process was adopted to anchor the dye onto cellulosic paper. It was found that the use of CNC resulted in a significant improvement in the SO coloration efficiency. The color stability and fatigue resistance were also studied. The use of CNC as carriers for a hydrophobic compound, its enhancement of associated properties, and its subsequent application were demonstrated. PMID:25037370

Sun, Bo; Hou, Qingxi; He, Zhibin; Liu, Zehua; Ni, Yonghao

2014-10-13

63

The large outbursts studied by small telescopes - the case of RS Oph  

NASA Astrophysics Data System (ADS)

Cataclysmic variables (CVs) are one of the dominant part in astronomical research. Small telescopes are widely used to search for the sudden brightening of such stars. We present our experience with observations of the RS Ophiuchi (RS Oph) and analyses of the light curves. RS Oph is a binary system with 6 recorded outbursts classified as a recurrent nova (RN). We used the telescopes of AI SAS to measure the brightness of RS Oph after its last outburst occurred on February 12, 2006. The new observations indicate the ongoing mass transfer. % and the estimation of the mass transfer rate allow to make a prediction of the %next outburst of this RN.

Kundra, E.; Hric, L.

2014-03-01

64

Continuous tone printing in silicone from CNC milled matrices  

NASA Astrophysics Data System (ADS)

Current research at the Centre for Fine Print Research (CFPR) at the University of the West of England, Bristol, is exploring the potential of creating coloured pictorial imagery from a continuous tone relief surface. To create the printing matrices the research team have been using CNC milled images where the height of the relief image is dictated by creating a tone curve and then milling this curve into a series of relief blocks from which the image is cast in a silicone ink. A translucent image is cast from each of the colour matrices and each colour is assembled - one on top of another - resulting is a colour continuous tone print, where colour tone is created by physical depth of colour. This process is a contemporary method of continuous tone colour printing based upon the Nineteenth Century black and white printing process of Woodburytype as developed by Walter Bentley Woodbury in 1865. Woodburytype is the only true continuous tone printing process invented, and although its delicate and subtle surfaces surpassed all other printing methods at the time. The process died out in the late nineteenth century as more expedient and cost effective methods of printing prevailed. New research at CFPR builds upon previous research that combines 19th Century Photomechanical techniques with digital technology to reappraise the potential of these processes.

Hoskins, S.; McCallion, P.

2014-02-01

65

The Design of Free Surface Interpolator for CNC Machining  

NASA Astrophysics Data System (ADS)

This article provides a design for the real-time interpolator of the B-Spline free surface. The goal is to increase both the accuracy and the speed of manufacturing production by eliminating the bottleneck caused by the off-line interpolator of the CNC tool machines, by reducing manufacturing errors, and by resolving the issue of long numeric control code (NC code). The design of the surface interpolator includes location planning using the real-time cutter contact data, the interpolation of the cutter contact data, and the cutting compensation of the cutter location data. This paper provides a surface interpolation method for reading the surface NC code of a three-dimensional surface and for implementing the surface interpolation. To simplify the complexity of the calculation, one can first use knot interpolation to decompose the B-Spline surface into sections of Bezier surface, which are then used as the surface for real-time surface interpolation. Subsequently, the approximation of the second order Taylor expansion is used to obtain the location interpolation points. Fixed machining parameters are adopted to avoid the low efficiency and low quality of manufacturing caused by variation of the feeding speed. The derived cutting locations are further combined to obtain the cutting locations of the original B-Spline surface. The verification of the experiments is shown with comparing the manufacturing profile errors and any variation of the feeding speed derived from computer simulation and the corresponding data obtained from the off-line interpolators.

Tseng, Pai-Chung; Hon, Jung-Yong

66

Time-resolved Spectroscopy of RS Canum Venaticorum Short-Period Systems. II. RT Andromedae, WY Cancri, and XY Ursae Majoris  

NASA Astrophysics Data System (ADS)

We present the second part of the results of our spectroscopic study of orbital phase resolution of short-period active binaries. In this paper we present the observations of the binaries RT And, WY Cnc, and XY UMa, for which we obtained simultaneous low-resolution spectra in the H?, H?, and Ca II infrared triplet (IRT; 8498 and 8542 Å) lines, and higher resolution spectra in H? for WY Cnc and XY UMa. H? and H? emission excess was found in all the observed orbital phases of WY Cnc and XY UMa, while RT And showed H? emission only during some orbital phases. We measure a clear Ca II (IRT) excess in all the spectra of the three binaries. The ratio of the flux excesses derived for these binaries, E_H?/E_H?~= 1-3 and E_8542/E_8498~= 1-3, give low values typical of solar plage structures. In the higher resolution H? spectra, we found emissions that can be associated with both stellar components of XY UMa and WY Cnc, indicating that the faint secondary stars in both binaries are active late-type dwarfs. Some H? emission components, which could originate in extended structures between the stars, were detected in both systems.

Arévalo, M. J.; Lázaro, C.

1999-08-01

67

Synthesis of chemical cross-linked gelatin hydrogel reinforced with cellulose nanocrystals (CNC)  

NASA Astrophysics Data System (ADS)

A novel method was performed to obtain hydrogel with superior sensitivity towards changes in pH and temperature by incorporation of CNC into gelatin based hydrogel. Glutaraldehyde was used as cross-linker due to its high chemical reactivity towards NH2 group on gelatin. Different ratio of gelatin / CNC hydrogel was produced in order to study the effects of CNC towards the swelling behaviour of hydrogel at different pH and temperature. Swelling tests were performed at different pH range from pH 3 to pH 11. Temperature swelling tests were performed at 25 °C and 37 °C. The hydrogel showed impressive pH sensitivity and maximum swelling was obtained at pH 3. Higher swelling ratio was observed at higher temperature. SEM micrographs showed that the pore size of hydrogel decreased with increasing CNC content due to formation of more rigid hydrogel structure. The characteristics of the hydrogel to respond to different pH and temperature suggest that gelatin / CNC hydrogel are promising candidates to be developed as drug carrier.

Yin, Ooi Shok; Ahmad, Ishak; Amin, Mohd. Cairul Iqbal Mohd

2014-09-01

68

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese.  

PubMed

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity was investigated in 1438 unrelated subjects from Latvia, Lithuania and Taiwan. In general, polymorphism of each individual locus showed tendencies similar to determined previously in HapMap populations. Main differences concern Taiwanese and include presence of rs2277460 rare allele A not found before in Asians and absence of rs2295827 rare alleles homozygotes TT observed in all other human populations. Observed patterns of SNPs and haplotype diversity were compatible with expectation of neutral model of evolution. Linkage disequilibrium between the rs2295826 and rs2295827 was detected to be complete in Latvians and Lithuanians (D? = 1; r(2) = 1) and slightly disrupted in Taiwanese (D? = 0.978; r(2) = 0.901). Population differentiation (FST statistics) was estimated from pairwise population comparisons of loci variability, five locus haplotypes and PSMA6 and PSMC6 two locus haplotypes. Latvians were significantly different from all Asians at each of 5 SNPs and from Lithuanians at the rs1048990 and PSMC6 loci. Lithuanian and Asian populations exhibited similarities at the PSMC6 loci and were different at the PSMA6 and PSMA3 SNPs. Considering five locus haplotypes all European populations were significantly different from Asian; Lithuanian population was different from both Latvian and CEU. Allele specific patterns of transcription factor binding sites and splicing signals were predicted in silico and addressed to eventual functionality of nucleotide substitutions and their potential to be involved in human genome evolution and geographical adaptation. Current study represents a novel step toward a systematic analysis of the proteasomal gene genetic diversity in human populations. PMID:25606411

Sjakste, Tatjana; Paramonova, Natalia; Wu, Lawrence Shi-Shin; Zemeckiene, Zivile; Sitkauskiene, Brigita; Sakalauskas, Raimundas; Wang, Jiu-Yao; Sjakste, Nikolajs

2014-12-01

69

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese  

PubMed Central

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity was investigated in 1438 unrelated subjects from Latvia, Lithuania and Taiwan. In general, polymorphism of each individual locus showed tendencies similar to determined previously in HapMap populations. Main differences concern Taiwanese and include presence of rs2277460 rare allele A not found before in Asians and absence of rs2295827 rare alleles homozygotes TT observed in all other human populations. Observed patterns of SNPs and haplotype diversity were compatible with expectation of neutral model of evolution. Linkage disequilibrium between the rs2295826 and rs2295827 was detected to be complete in Latvians and Lithuanians (D? = 1; r2 = 1) and slightly disrupted in Taiwanese (D? = 0.978; r2 = 0.901). Population differentiation (FST statistics) was estimated from pairwise population comparisons of loci variability, five locus haplotypes and PSMA6 and PSMC6 two locus haplotypes. Latvians were significantly different from all Asians at each of 5 SNPs and from Lithuanians at the rs1048990 and PSMC6 loci. Lithuanian and Asian populations exhibited similarities at the PSMC6 loci and were different at the PSMA6 and PSMA3 SNPs. Considering five locus haplotypes all European populations were significantly different from Asian; Lithuanian population was different from both Latvian and CEU. Allele specific patterns of transcription factor binding sites and splicing signals were predicted in silico and addressed to eventual functionality of nucleotide substitutions and their potential to be involved in human genome evolution and geographical adaptation. Current study represents a novel step toward a systematic analysis of the proteasomal gene genetic diversity in human populations. PMID:25606411

Sjakste, Tatjana; Paramonova, Natalia; Wu, Lawrence Shi-Shin; Zemeckiene, Zivile; Sitkauskiene, Brigita; Sakalauskas, Raimundas; Wang, Jiu-Yao; Sjakste, Nikolajs

2014-01-01

70

Silicate Dust in RS Ophiuchi  

NASA Astrophysics Data System (ADS)

We present Spitzer IRS spectra of the recurrent nova RS Ophiuchi obtained between 2006 and 2009. The data show emission lines due to HI, [Ne II], [Ne V], [Ne VI] and [O IV] and the well known silicate features at 10 ?m and 18 ?m, whose behaviour are reported here. The silicate features are variable in the period covered by the observations, appearing strongest in our 2007 data. Interestingly, the central wavelength of the 18 ?m band is shorter than observed in other symbiotic systems and other circumstellar environments, suggesting unusual grain properties in RS Oph. We report changes that have taken place in the dusty environment in RS Oph and investigate the properties of the dust grains.

Rushton, M. T.; Woodward, C. E.; Helton, L. A.; Gehrz, R. D.; Evans, A.; Kaminsky, B.; Pavlenko, Y. V.; Eyres, S. P. S.; Maxwell, M.

2014-12-01

71

F- and G-type stars with planetary companions: Andromedae, 1 Cancri, Bootis, 16 Cygni and Coronae Borealis?  

Microsoft Academic Search

Accurate stellar parameters are presented for the F- and G-type stars And, 1 Cnc, Boo, 16 Cyg, and CrB, which are deemed to possess planetary companions from intense Doppler monitoring. Evolutionary tracks that employ detailed model atmospheres as upper boundary condition and allow for helium diffusion are computed for the individual stars to derive the stellar masses and ages. From

Klaus Fuhrmann; Michael J. Pfeiffer; Jan Bernkopf

72

Radial Error Feedback Geometric Adaptive Control for Bar Turning in CNC Turning Centers  

E-print Network

) turning machines. Bars can be used as shafts of all kinds of machinery, including automobiles, aircraft influences the performance of these machines. Because of increasing global market competition, more stringent. The major strategy for in-process measurement and control of CNC machines is geometric adaptive control (GAC

Collins, Emmanuel

73

CNC Machine Tool's Wear Diagnostic and Prognostic by Using Dynamic Bayesian Networks  

E-print Network

CNC Machine Tool's Wear Diagnostic and Prognostic by Using Dynamic Bayesian Networks D.A. Tobon on-line system diagnostics and prognostics. The present paper is a contribution on the assessment's behavior of the cutting tool. Then, in the second phase, which is an assessment one, the constructed models

Paris-Sud XI, Université de

74

Design and manufacture of a CNC desktop lathe for use in a project-based class  

E-print Network

The objective of this project is to evolve the design of a CNC desktop lathe for use in a project-based class and then fabricate a prototype to confirm the functionality of the design. This iteration of the lathe effectively ...

Hsieh, Jonathan C

2008-01-01

75

Real-Time, CNC Machine Tool Control with Linux: A Senior Design Project at MUSE  

Microsoft Academic Search

As machine tools age and their existing controllers fail, the machine tools must be either modernized or scrapped. This paper details the infusion of new technology and the resulting extended useful life of a computer numerical controlled (CNC) tabletop lathe. This work was undertaken as a senior design project by a group of senior engineers at Mercer University School of

Tie Duan; Ronnie Baroud; Daniel Amato; Albert LaRoe

76

CNC Turning Center Operations and Prove Out. Computer Numerical Control Operator/Programmer. 444-334.  

ERIC Educational Resources Information Center

This student guide provides materials for a course designed to instruct the student in the recommended procedures used when setting up tooling and verifying part programs for a two-axis computer numerical control (CNC) turning center. The course consists of seven units. Unit 1 discusses course content and reviews and demonstrates set-up procedures…

Skowronski, Steven D.

77

Basic CNC Operation. Training Workbook [and] Assessment and Training Guide [and] Hands-on Assessment.  

ERIC Educational Resources Information Center

This workbook is intended for students taking a course in basic computer numerical control (CNC) operation that was developed during a project to retrain defense industry workers at risk of job loss or dislocation because of conversion of the defense industry. The workbook contains daily training guides for each of the course's 13 sessions. Among…

Anoka-Hennepin Technical Coll., Minneapolis, MN.

78

Technical and Symbolic Knowledge in CNC Machining: A Study of Technical Workers of Different Backgrounds.  

ERIC Educational Resources Information Center

Performances of 45 individuals with varying degrees of formal and informal training in machining and programming were compared on tasks designed to tap intellectual changes that may occur with the introduction of computer numerical control (CNC). Participants--30 machinists, 8 machine operators, and 7 engineers--were asked background questions and…

Martin, Laura M. W.; Beach, King

79

Applications of position controller for CNC machines based on state observer and Cross Coupled Controller  

Microsoft Academic Search

This paper proposes an integrated motion control structure to realize the precise multi-axis movement controlling for high precision computer numerical control (CNC) system. On the base of the system model, three elements are applied: Zero Phase Error Tracking Controller (ZPETC), the state observer and the Cross Coupling Controller (CCC). ZPETC improves the frequency response of the tracking control system; the

Liu Qing; Wang Tai-yong; Dong Jing-chuan; Jiang Yong-xiang; Li Bo

2010-01-01

80

Maximum Feedrate Interpolator for Multi-axis CNC Machining with Jerk Constraints  

E-print Network

a smooth movement. For machining operations, the main goal is to follow precisely a given geometric pathMaximum Feedrate Interpolator for Multi-axis CNC Machining with Jerk Constraints X. Beudaert, S means to generate the setpoints for each machine tool axis. The aim of the VPOp algorithm is to make

Paris-Sud XI, Université de

81

White Dwarfs in Binary Systems A white dwarf orbiting another star can become active  

E-print Network

White Dwarfs in Binary Systems A white dwarf orbiting another star can become active when the other. Explosions from White Dwarf Star RS Oph #12;Classical Novae: RS Ophiuci Recurrent Nova RS Ophiuci Explosions becomes incandescent. #12;H and He from the companion build up on the white dwarf's surface. Classical

Barnes, Joshua Edward

82

Emisión H? en sistemas binarios cromosféricamente activos (RS CVn y BY Dra)  

NASA Astrophysics Data System (ADS)

We report here high and medium resolution Balmer H? line profiles for 11 chromospherically active binary systems including the class of RS Canum Venaticorum binaries (RS CVn) and BY Draconis (BY Dra) with a total range of rotation periods from 0.8 to 24 days. We have obtained different types of H? line profiles: strong emission line, weak emission line with strong superposed absorption profile and filled-in absorption line profile. We have measured the H? equivalent width of the program stars and the H? core emission was determined by subtraction of the equivalent width of a presumably inactive star with the same spectral type and luminosity class.

Fernández-Figueroa, M. J.; Montes, D.; de Castro, E.

1992-05-01

83

Rotational modulation and flares on RS CVn and BY Dra-type stars. I - Photometry and spot models for BY Dra, AU Mic, AR Lac, II Peg and V 711 Tau (= HR 1099)  

NASA Technical Reports Server (NTRS)

Multicolor wide-band photometry of five active stars is presented. The observations were carried out at several places before, during and after the period of IUE observations for the purpose of determining the location, sizes, and evolution of photospheric spots at the time when chromospheric, transition region, and coronal activity data were obtained from UV and radio observations. II Peg, BY Dra, and AU Mic show fairly stable quasi-sinusoidal light curves, while AR Lac and V 711 Tau show double-peaked light curves. For V 711 Tau, a remarkable evolution of the spotted area extent and/or longitude distribution is found. Small, but definite color variations that are consistent with the cool spot hypothesis have also been detected for BY Dra, II Peg and V 711 Tau.

Rodono, M.; Cutispoto, G.; Pazzani, V.; Catalano, S.; Byrne, P. B.

1986-01-01

84

Facile synthesis of CNC-MnO2 hybrid as a supercapacitor electrode  

NASA Astrophysics Data System (ADS)

A facile and efficient hydrothermal approach has been developed to synthesize three dimensional hybrid of manganese dioxide (MnO2) and carbon nanocoils (CNCs) as a kind of electrode materials for supercapacitors. This hybrid is prepared by anchoring uniformly porous MnO2 nanowiskers over the surface of CNCs. The electrochemical properties of CNC-MnO2 electrode have been measured by a three electrode configuration, which exhibits high specific capacitance with values up to 387 F/g at a scan rate of 10 mV/s and good cycling stability. These results suggest that the CNC-MnO2 hybrid is comparable or superior to other carbon-based materials coated with MnO2 nanowiskers.

Su, Deqiao; Pan, Lujun; Fu, Xin; Ma, He

2015-01-01

85

Real-time PH curve CNC interpolators for high speed cornering  

Microsoft Academic Search

In this paper, real-time Pythagorean hodograph (P-H) curve CNC interpolators are used for high speed corner machining. There\\u000a are large contouring errors around sharp corners when low-bandwidth servo controllers (such as P-PI control) are used. In\\u000a order to decrease the amount of the cornering errors, an improved interpolation method is proposed. The first deceleration\\u000a phase of motion and the over-corner

Javad Jahanpour; Behnam Moetakef Imani

2008-01-01

86

Tool path planning for 5-axis flank milling of ruled surfaces considering CNC linear interpolation  

Microsoft Academic Search

This paper investigates tool path planning for 5-axis flank milling of ruled surfaces in consideration of CNC linear interpolation.\\u000a Simulation analyses for machining error show insights into the tool motion that generates a precision machined surface. Contradicting\\u000a to previous thoughts, the resultant tool path does not necessarily produce minimal machining error when the cutter contacts\\u000a the rulings of a developable

Chih-Hsing Chu; Ping-Han Wu; Wei-Tai Lei

87

Time-stamped cross-coupled control in networked CNC systems  

Microsoft Academic Search

This paper proposes a time-stamped cross-coupled control (TSCCC) algorithm to deal with the asynchronous sampling and network-induced delays in networked computer numerical control (CNC) machines. It uses time-stamps to estimate the network-induced delays from the sampling instants of different axes to the controller node. The network-induced delays are considered for accurately estimating the contour error in real-time. Furthermore, a networked

Xiong Xu; Xinjun Sheng; Zhenhua Xiong; Xiangyang Zhu

2011-01-01

88

9th Biannual Joint Technical Day of CIE/USA and CNC/CIE, Davis, CA, 7 Nov. 2013 Improving Traceability of  

E-print Network

), textiles (AATCC) #12;9th Biannual Joint Technical Day of CIE/USA and CNC/CIE, Davis, CA, 7 Nov. 2013 CIE9th Biannual Joint Technical Day of CIE/USA and CNC/CIE, Davis, CA, 7 Nov. 2013 Improving/CIE and CNC/CIE Technical Day 7 November 2013 Joanne Zwinkels, William Neil and Mario Noël Measurement Science

California at Davis, University of

89

X-ray spectra and the rotation-activity connection of RS Canum Venaticorum binaries  

NASA Astrophysics Data System (ADS)

Results are presented from a survey of RS CVn binaries which were observed with the imaging proportional counter (IPC) on board the Einstein Observatory. Spectral analyses of the IPC pulse height spectra show that the coronae of RS CVn binaries always contain hot gas with temperatures in excess of 10 to the 7th K, similar to active late-type main-sequence stars, and that at least two temperature components are necessary to account for the higher quality IPC spectra (when absorption is unimportant). It is argued that these bimodal temperature distributions found by the IPC are indicative of true distributions of emission measure versus temperature that are continuous (just as is the case of magnetically confined coronal plasma loops observed on the sun). It is further shown that none of the derivable X-ray characteristics of RS CVn binaries depend on rotation period, implying that previous claims of period-activity relationships in RS CVn binaries were unfounded.

Majer, P.; Schmitt, J. H. M. M.; Golub, L.; Harnden, F. R., Jr.; Rosner, R.

1986-01-01

90

Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566) genes in Thai cervical cancer patients with HPV 16 infection.  

PubMed

The risk of cervical cancer development in women infected with HPV varies in relation to the individual host's genetic makeup. Many studies on polymorphisms as genetic factors have been aimed at analyzing associations with cervical cancer. In this study, single nucleotide polymorphisms (SNPs) in 3 genes were investigated in relation to cervical cancer progression in HPV16 infected women with lesions. Two thousand cervical specimens were typed by PCR sequencing methods for TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566). Ninety two HPV16 positive cases and thirty two normal cases were randomly selected. Analysis of TP53 (rs1042522) showed a significantly higher frequency in cancer samples (OR=1.22, 95%CI=1.004-1.481, p-value=0.016) while differences in frequency were not significant within each group (p-value=0.070). The genotype distributions of p16 (rs11515 and rs3088440) and NQO1 (rs1800566) did not show any significantly higher frequency in cancer samples (p-value=0.106, 0.675 and 0.132, respectively) or within each group (p-value=0.347, 0.939 and 0.111, respectively). The results indicated that the polymorphism in TP53 (rs1042522) might be associated with risk of cervical cancer development in HPV16 infected women. Further studies of possible mechanisms of influence on cervical cancer development would be useful to manage HPV infected patients. PMID:23534750

Chansaenroj, Jira; Theamboonlers, Apiradee; Junyangdikul, Pairoj; Swangvaree, Sukumarn; Karalak, Anant; Chinchai, Teeraporn; Poovorawan, Yong

2013-01-01

91

CNC machine tool's wear diagnostic and prognostic by using dynamic Bayesian networks  

NASA Astrophysics Data System (ADS)

The failure of critical components in industrial systems may have negative consequences on the availability, the productivity, the security and the environment. To avoid such situations, the health condition of the physical system, and particularly of its critical components, can be constantly assessed by using the monitoring data to perform on-line system diagnostics and prognostics. The present paper is a contribution on the assessment of the health condition of a computer numerical control (CNC) tool machine and the estimation of its remaining useful life (RUL). The proposed method relies on two main phases: an off-line phase and an on-line phase. During the first phase, the raw data provided by the sensors are processed to extract reliable features. These latter are used as inputs of learning algorithms in order to generate the models that represent the wear's behavior of the cutting tool. Then, in the second phase, which is an assessment one, the constructed models are exploited to identify the tool's current health state, predict its RUL and the associated confidence bounds. The proposed method is applied on a benchmark of condition monitoring data gathered during several cuts of a CNC tool. Simulation results are obtained and discussed at the end of the paper.

Tobon-Mejia, D. A.; Medjaher, K.; Zerhouni, N.

2012-04-01

92

AT Cnc: A SECOND DWARF NOVA WITH A CLASSICAL NOVA SHELL  

SciTech Connect

We are systematically surveying all known and suspected Z Cam-type dwarf novae for classical nova shells. This survey is motivated by the discovery of the largest known classical nova shell, which surrounds the archetypal dwarf nova Z Camelopardalis. The Z Cam shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts, in accord with the hibernation scenario of cataclysmic binaries. Here we report the detection of a fragmented 'shell', 3 arcmin in diameter, surrounding the dwarf nova AT Cancri. This second discovery demonstrates that nova shells surrounding Z Cam-type dwarf novae cannot be very rare. The shell geometry is suggestive of bipolar, conical ejection seen nearly pole-on. A spectrum of the brightest AT Cnc shell knot is similar to that of the ejecta of the classical nova GK Per, and of Z Cam, dominated by [N II] emission. Galaxy Evolution Explorer FUV imagery reveals a similar-sized, FUV-emitting shell. We determine a distance of 460 pc to AT Cnc, and an upper limit to its ejecta mass of {approx}5 Multiplication-Sign 10{sup -5} M {sub Sun }, typical of classical novae.

Shara, Michael M.; Mizusawa, Trisha; Zurek, David [Department of Astrophysics, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024-5192 (United States); Wehinger, Peter [Steward Observatory, the University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Martin, Christopher D.; Neill, James D.; Forster, Karl [Department of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Mail Code 405-47, Pasadena, CA 91125 (United States); Seibert, Mark [Observatories of the Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States)

2012-10-20

93

Non-contact automatic measurement of free-form surface profiles on CNC machines  

NASA Astrophysics Data System (ADS)

This paper describes the work to develop a non-contact type automatic measurement system for any free-form surfaces on a CNC machine tool or a coordinate measuring machine (CMM) and its CAD/CAM integration. A laser probe made by Keyence Co. model LC-2220 was integrated into the CNC machine as the non-contact sensor. A measurement software has been developed for automatic surface tracing of any free-form profile. Data transfer to any commercially available CAD/CAM system for reverse engineering is also available via proper DXF file. Extensive calibration work has been carried out on the systematic accuracy of the laser probe with respect to the color material surface slope and edge detection of the workpiece by the use of a HP5528 laser interferometer system. Having employed the surface painting technique the shape error of the copied object relative to its master piece was found within 30 micrometers which is deemed adequate enough to the mold industry.

Fan, Kuang-Chao; Wen, Kuang-Pu

1993-09-01

94

Fast manufacturing of E-ELT mirror segments using CNC polishing  

NASA Astrophysics Data System (ADS)

We report on the first-ever demonstration of grinding and polishing full-size, off-axis aspheric, mirror segments as prototypes for an extremely large telescope, processed entirely in the final hexagonal shape. We first describe the overall strategy for controlling form and mid spatial frequencies, at levels in the vicinity of <10nm RMS surface. This relies first on direct CNC grinding of the base-form of these 1.4m segments, using the Cranfield BoX™ machine. The segments are then mounted on a custom designed (Optic Glyndwr Optoelectronic Engineering Group) three segment hydraulic support, and CNC polished on a Zeeko IRP 1600 machine using a variety of custom tooling. We overview the fullaperture and sub-aperture metrology techniques used to close the process-loop and certify quality, all of which operate with the segment in-situ on the IRP1600. We then focus on the pristine edge-definition achieved by the combination of tool-lift and smoothing operations; results never previously demonstrated on full-size pre-cut hexagonal segments. Finally, the paper discusses the feasibility of scaling the process to deliver 931 segments in seven years, as required for the E-ELT project.

Gray, C.; Baker, I.; Davies, G.; Evans, R.; Field, N.; Fox-Leonard, T.; Messelink, W.; Mitchell, J.; Rees, P.; Waine, S.; Walker, D. D.; Yu, G.

2013-09-01

95

AT Cnc: A Second Dwarf Nova with a Classical Nova Shell  

NASA Astrophysics Data System (ADS)

We are systematically surveying all known and suspected Z Cam-type dwarf novae for classical nova shells. This survey is motivated by the discovery of the largest known classical nova shell, which surrounds the archetypal dwarf nova Z Camelopardalis. The Z Cam shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts, in accord with the hibernation scenario of cataclysmic binaries. Here we report the detection of a fragmented "shell," 3 arcmin in diameter, surrounding the dwarf nova AT Cancri. This second discovery demonstrates that nova shells surrounding Z Cam-type dwarf novae cannot be very rare. The shell geometry is suggestive of bipolar, conical ejection seen nearly pole-on. A spectrum of the brightest AT Cnc shell knot is similar to that of the ejecta of the classical nova GK Per, and of Z Cam, dominated by [N II] emission. Galaxy Evolution Explorer FUV imagery reveals a similar-sized, FUV-emitting shell. We determine a distance of 460 pc to AT Cnc, and an upper limit to its ejecta mass of ~5 × 10-5 M ?, typical of classical novae.

Shara, Michael M.; Mizusawa, Trisha; Wehinger, Peter; Zurek, David; Martin, Christopher D.; Neill, James D.; Forster, Karl; Seibert, Mark

2012-10-01

96

The Neural-fuzzy Thermal Error Compensation Controller on CNC Machining Center  

NASA Astrophysics Data System (ADS)

The geometric errors and structural thermal deformation are factors that influence the machining accuracy of Computer Numerical Control (CNC) machining center. Therefore, researchers pay attention to thermal error compensation technologies on CNC machine tools. Some real-time error compensation techniques have been successfully demonstrated in both laboratories and industrial sites. The compensation results still need to be enhanced. In this research, the neural-fuzzy theory has been conducted to derive a thermal prediction model. An IC-type thermometer has been used to detect the heat sources temperature variation. The thermal drifts are online measured by a touch-triggered probe with a standard bar. A thermal prediction model is then derived by neural-fuzzy theory based on the temperature variation and the thermal drifts. A Graphic User Interface (GUI) system is also built to conduct the user friendly operation interface with Insprise C++ Builder. The experimental results show that the thermal prediction model developed by neural-fuzzy theory methodology can improve machining accuracy from 80µm to 3µm. Comparison with the multi-variable linear regression analysis the compensation accuracy is increased from ±10µm to ±3µm.

Tseng, Pai-Chung; Chen, Shen-Len

97

Experimental Investigation of Parameters of CNC Turning by Taguchi based Grey Relational Analysis  

NASA Astrophysics Data System (ADS)

The AISI H13, a chromium based hot work tool Steel has a wide variety of applications in aluminum casting and extrusion dies, forging dies, hot nut tools, hot header dies, extrusion mandrels, plastic molds, cores, die holder blocks, hot press dies and specially hot work punches etc. In this study, the optimization of two response parameters (Surface roughness and Material Removal Rate) by three machining parameters (cutting speed, feed rate and depth of cut) is investigated in high speed turning of H13 in dry conditions. Taguchi's L'18 orthogonal array and analysis of variance (ANOVA) are used for individual optimization. The simultaneous optimization is done by Grey Relational Analysis approach. The different levels of all machining parameters are used and experiments are done on HMT STALLION-100 HS CNC lathe machine. The optimum condition for combined effects was found V5-F1-D1 and the optimal value of the surface roughness (Ra) comes out to be 0.85 (μm) and of MRR is 488.8 (mm³/sec). The optimum results are also verified with the help of confirmation experiments. Keywords: CNC Turning, O

Sharma, Pankaj; Bhambri, Kamaljeet

2013-03-01

98

Operating R.S. Gaines Systems Editor  

E-print Network

Operating R.S. Gaines Systems Editor Cold-Start vs. Warm- Start Miss Ratios Malcolm C. Easton IBM, requires a fee and/or specific permission. Author's present addresses: M.C. Easton, IBM Thomas J. Watson

Fagin, Ron

99

R\\/S Statistic: Accuracy and Implementations  

Microsoft Academic Search

The paper studies the behaviour of three different R\\/S statistic algorithms for Hurst-index estimation in self-similar and long-range dependent discrete time series. The accuracy of the algorithms under convergence and aggregation in time is obtained and compared. The results show that static blocks implementations of the R\\/S statistic present better accuracy than those based on a dynamic blocks implementation. The

Julio C. Ramirez Pacheco; Deni Torres Roman; Leopoldo Estrada Vargas

2008-01-01

100

Advanced CNC and CAM Series. Educational Resources for the Machine Tool Industry. Course Syllabi, Instructor's Handbook [and] Student Laboratory Manual.  

ERIC Educational Resources Information Center

This package consists of course syllabi, an instructor's handbook, and student laboratory manual for a 1-year vocational training program to prepare students for entry-level positions as advanced computer numerical control (CNC) and computer-assisted manufacturing (CAM) technicians.. The program was developed through a modification of the DACUM…

Texas State Technical Coll. System, Waco.

101

78 FR 67215 - Norfolk Southern Railway Company-Abandonment Exemption-in Fayette and Wayne Counties, Ind.; C&NC...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Exemption--in Fayette and Wayne Counties, Ind.; C&NC Railroad Corporation-- Discontinuance...Exemption--in Fayette and Wayne Counties, Ind. Norfolk Southern Railway Company (NSR...450N in Connersville, Fayette County, Ind.) and milepost CB 5.41 (near...

2013-11-08

102

78 FR 46412 - Norfolk Southern Railway Company-Abandonment Exemption-in Henry County, Ind.; C&NC Railroad...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Railway Company--Abandonment Exemption--in Henry County, Ind.; C&NC Railroad Corporation--Discontinuance of Service...contiguous rail line segments in New Castle, in Henry County, Ind., as follows: (1) Approximately 0.12 miles of rail...

2013-07-31

103

Association between DRD2 (rs1799732 and rs1801028) and ANKK1 (rs1800497) polymorphisms and schizophrenia: a meta-analysis.  

PubMed

The role of dopamine D2 receptor (DRD2) polymorphisms in schizophrenia remains controversial. We performed a meta-analysis to determine whether DRD2 polymorphisms influence the risk of schizophrenia and examined the relationship between rs1799732, rs1801028, and rs1800rs028 an23381d rs1800497 genetic variants and the etiology of schizophrenia. Relevant case-control studies were retrieved by database searches and selected according to established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta-regression, subgroup analysis, sensitivity analysis, and cumulative meta-analysis were performed. A total of 76 studies with 16096 cases and 18965 controls were included. Specifically, 24 studies with 6075 cases and 6643 controls involved rs1799732, 36 studies with 8043 cases and 10194 controls involved rs1801028 and 16 studies with 1978 cases and 2128 controls involved rs1800497. No significant associations were observed between rs1799732 and rs1800rs732 and rs1800497 and schizophrenia. The rs1801028 locus was associated with schizophrenia, with a pooled OR of 1.221 (95% CI = 1.037-1.438, P = 0.016). This meta-analysis indicates that the rs1801028 locus may be associated with schizophrenia. These data provide possible references for future case-control studies related to schizophrenia. PMID:25504812

Yao, Jun; Pan, Yu-qing; Ding, Mei; Pang, Hao; Wang, Bao-jie

2015-01-01

104

A Survey of Short-Period RS CVN Binaries  

NASA Astrophysics Data System (ADS)

We propose to observe a number of active, late-type binary systems with periods of around one day or less, so as to investigate the structure of chromospheres and transition regions in solar-type stars that, due to tidal synchronism, have rapid rotation rates of 25 to 100 km/sec. We will determine the existence of functional dependences of ultraviolet line fluxes on quantities such as period, Rossby number, and spectral type within this class of systems. We will compare the spectra of these systems to the shorterperiod W UMa contact binary systems and to RS CVn binaries of longer period, in order to verify whether there is a "global" rotation-activity relation for the entire range of rotation rates seen in late-type binary stars, or whether, on the other hand, there is evidence for "breaks" in the relation at certain critical periods. We will use these data to provide constraints on the dynamo models for generating activity in rotating, convective stars.

Drake, Stephen A.

105

Association of ERCC1 rs3212986 & ERCC2 rs13181 polymorphisms with the risk of glioma  

PubMed Central

Objective: : Several previous studies have reported the role variant of ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms in the risk of glioma, but the results of these studies are inconsistent. Therefore, we aimed to conduct a meta-analysis to investigate the role of ERCC1 rs3212986 and ERCC2 rs13181 on the risk of glioma. Methods: A comprehensive research was conducted through the databases of Pubmed, EMBASE and the China National Knowledge Infrastructure (CNKI) platforms until June 1, 2014, including 14 eligible case-control studies. Results: Our meta-analysis found that ERCC1 rs3212986 AA genotype was significantly associated with increased risk of glioma compared with CC genotype, and the pooled OR (95%CI) was 1.29(1.07-1.55). By subgroup analysis, ERCC1 rs3212986 AA genotype was found to be significantly correlated with increased glioma risk in Chinese population (OR=1.37, 95%CI=1.07, 1.55), Similarly, we found that ERCC2 rs13181 GT and TT genotypes were significantly associated with increased risk of glioma in Chinese population, with ORs(95%CI) of 1.47(1.17-1.85) and 1.50(1.02-2.22). But ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms had no significant association with glioma risk in Caucasian populations. By begg’s funnel plot, we found that no publication bias was existed in this meta-analysis. Conclusion: Our meta-analysis suggested that ERCC1 rs3212986 and ERCC2 rs13181 polymorphism play an important risk factor for brain tumor development in Chinese population, but no association in Caucasian populations.

Cui, Qing-ke; Zhu, Jian-xin; Liu, Wei-dong; Wang, Yun-hua; Wang, Zhi-gang

2014-01-01

106

(1) tRNA aaRS Woods ( ) Baeck  

E-print Network

12 10 4 * DNA10 (1)(2) DNA #12;WT WT tRNA L- tRNA TyrRS WT TyrRS TyrRS X L- 20 20 20 2=1,600 16,000 TyrRS WT (1) Sakamoto, K., Hayashi, A., Sakamoto, A., Kiga, D., Nakayama, H., Soma, A., Kobayashi, T

Hagiya, Masami

107

Wisconsin Longitudinal Study SNPs Gene rs # disease/behavior notes  

E-print Network

Impulsivity, Parkinson's 3' near gene, 0.50 heterozygosity DRD2 rs1800497 Nicotine/Alchol addiction Taq Cancer not listed in dbSNP CYP2A6 rs5031016 Nicotine addiction exonic, missense, 0.01 heterozygosity rs4680 Cognitive Aging, Impulsivity exonic, missense, 0.47 heterozygosity AR rs6152 Cognitive Aging

Wisconsin at Madison, University of

108

Optimization of Operation Sequence in CNC Machine Tools Using Genetic Algorithm  

NASA Astrophysics Data System (ADS)

The productivity of machine tools is significantly improved by using microcomputer based CAD/CAM systems for NC program generation. Currently, many commercial CAD/CAM packages that provide automatic NC programming have been developed and applied to various cutting processes. Many cutting processes machined by CNC machine tools. In this paper, we attempt to find an efficient solution approach to determine the best sequence of operations for a set of operations that located in asymmetrical locations and different levels. In order to find the best sequence of operations that achieves the shortest cutting tool travel path (CTTP), genetic algorithm is introduced. After the sequence is optimized, the G-codes that use to code for the travel time is created. CTTP can be formulated as a special case of the traveling salesman problem (TSP). The incorporation of genetic algorithm and TSP can be included in the commercial CAD/CAM packages to optimize the CTTP during automatic generation of NC programs.

Abu Qudeiri, Jaber; Yamamoto, Hidehiko; Ramli, Rizauddin

109

Study on grinding of free-form optics surface in three-axis CNC machine  

NASA Astrophysics Data System (ADS)

Due to the glass is a type of brittle material, so the high-precision free-form optics of glass material is usually machined by the technical of grinding. In this paper, for the characteristics of the diamond grinding wheel, analyzing the grinding path of free-form optics and mathematical model of the path is established based on the three-axis CNC grinding device. Moreover, the cause of the interference in the process of grinding is analyzed and the methods of avoiding. Finally, based on the above analysis results, through the experiment, the free-form optics surface accuracy was reached to 3.6um, realize the machining of the free-form optics.

Yang, Haicheng; Zhang, Yun-long; Zhang, Feng; Wang, Zhibin; Bao, Long-xiang; Su, Ying; Guo, Rui; Liu, Xuan-min

2014-08-01

110

Concurrent Collections (CnC): A new approach to parallel programming  

ScienceCinema

A common approach in designing parallel languages is to provide some high level handles to manipulate the use of the parallel platform. This exposes some aspects of the target platform, for example, shared vs. distributed memory. It may expose some but not all types of parallelism, for example, data parallelism but not task parallelism. This approach must find a balance between the desire to provide a simple view for the domain expert and provide sufficient power for tuning. This is hard for any given architecture and harder if the language is to apply to a range of architectures. Either simplicity or power is lost. Instead of viewing the language design problem as one of providing the programmer with high level handles, we view the problem as one of designing an interface. On one side of this interface is the programmer (domain expert) who knows the application but needs no knowledge of any aspects of the platform. On the other side of the interface is the performance expert (programmer or program) who demands maximal flexibility for optimizing the mapping to a wide range of target platforms (parallel / serial, shared / distributed, homogeneous / heterogeneous, etc.) but needs no knowledge of the domain. Concurrent Collections (CnC) is based on this separation of concerns. The talk will present CnC and its benefits. About the speaker Kathleen Knobe has focused throughout her career on parallelism especially compiler technology, runtime system design and language design. She worked at Compass (aka Massachusetts Computer Associates) from 1980 to 1991 designing compilers for a wide range of parallel platforms for Thinking Machines, MasPar, Alliant, Numerix, and several government projects. In 1991 she decided to finish her education. After graduating from MIT in 1997, she joined Digital Equipment?s Cambridge Research Lab (CRL). She stayed through the DEC/Compaq/HP mergers and when CRL was acquired and absorbed by Intel. She currently works in the Software and Services Group / Technology Pathfinding and Innovation.

None

2011-10-06

111

Using RS CVn Binaries as a Novel Approach to Measuring Gravity Darkening  

NASA Astrophysics Data System (ADS)

Faint companions of bright giant stars (e.g. RS CVn binaries) are often undetected by direct observations due to small angular distances and large flux ratios. Taking advantage of recent upgrades to the Michigan Infrared Combiner (MIRC) at the CHARA Array allowing for milliarcsecond resolution and large flux ratio detections (>250:1), we make the first detections of the faint main-sequence companions to the giant primary stars of RS CVn systems. These observations give orbital parameter determinations, which lead to model-independent component mass measurements and more accurate evolutionary state estimates. Using the new orbital parameters and 25 years of archival photometry, we have identified weak ellipsoidal variations allowing for a new look at gravity darkening.

CHARA Collaboration

2015-01-01

112

EUV Emission from RS Canum Venaticorum binaries.  

NASA Astrophysics Data System (ADS)

We performed a study of 104 RS CVn systems in the extreme ultraviolet (EUV) using the all-sky survey data obtained by the Extreme Ultraviolet Explorer (EUVE). The present sample includes several new RS CVn detections; 11 more than in the published EUVE catalogs, and 8 more than in the ROSAT Wide Field Camera catalog. The ratio of detections to non-detections remained constant throughout the sky, implying that our detections are not limited by the exposure time but are most likely limited by absorption from the interstellar medium. A general trend of increasing Lex/B (50-180Å) flux with decreasing rotational period is clear. The dwarf systems exhibit a leveling-off for the faster rotators. In contrast, the evolved systems exhibit no such effect. For the RS CVn systems the losses in the EUV represent a smaller fraction of the coronal radiative losses, as compared to active late-type dwarfs.

Mitrou, C. K.; Mathioudakis, M.; Doyle, J. G.; Antonopoulou, E.

1997-02-01

113

Documentation for the machine-readable version of the Catalogue of Nearby Stars, edition 1969  

NASA Technical Reports Server (NTRS)

The Catalogue of Nearby Stars, Edition 1969 (Gliese 1969) contains a number of modifications and additions to the 1957 catalog. It should be mentioned that the 1969 edition lists: (1) all 915 stars of the first edition, even though newer parallaxes place some of the stars below the catalog limit; (2) almost all known stars having trigonometric parallaxes or = 0.045 deg, although in some cases the mean values of trigonometric and spectral or photometric parallaxes are or = 0.045 deg. Pleiades stars and the carbon star X Cnc have been omitted; and (3) all stars with mean (resulting) parallaxes or = 0.045 deg. The resulting catalog contains 1529 single stars and systems with a total of 1890 components (not including spectroscopic and astrometric companions). The machine-readable version of the catalog is described. It is intended to enable users to read and process the data without problems or guesswork.

Warren, W. H., Jr.

1982-01-01

114

Association of the four common polymorphisms in interleukin-10 (rs1800890, rs1800896, rs1800871, and rs1800872) with non-Hodgkin’s lymphoma risk: a meta-analysis  

PubMed Central

Interleukin-10 (IL-10) single nucleotide polymorphisms (SNPs) have been indicated to be correlated with Non-Hodgkin’s lymphoma (NHL) susceptibility. However, the results of these studies on the association remain inconsistent. This meta-analysis was conducted to derive a more accuracy estimation of the association between the common SNPs (rs1800890, rs1800896, rs1800871 and rs1800872) in IL-10 and NHL risk. Meta-analyses were performed on 21 studies with 7,749 cases and 8584 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the NHL risk. Meta-analyses showed that rs1800890, rs1800871 and rs1800872 polymorphisms had no association with NHL risk. However, rs1800896 polymorphism has association with NHL risk based on the following comparison models (G vs. A: OR = 1.14, 95% CI = 1.00-1.29; AG vs. AA: OR = 1.20, 95% CI = 1.05-1.37; GG+AG vs. AA: OR = 1.22, 95% CI = 1.08-1.39). In the ethnic subgroup analysis, rs1800896 had an increased NHL risk in Caucasians based on the heterozygote model (OR = 1.21, 95% CI = 1.04-1.41) and dominant model (OR = 1.22, 95% CI = 1.00-1.48). When stratified by subtypes, rs1800890, rs1800896 and rs1800872 polymorphisms were found significant association with an increased risk of diffuse large B-cell Lymphoma (DLBCL) in different comparison models, whereas negative results were obtained for Follicular Lymphoma (FL) and chronic lymphocytic Leukemia/small lymphocytic Lymphoma (CLL/SLL) in all genetic models. Our meta-analysis suggested that the rs1800896 polymorphism had an increased risk with NHL susceptibility, where as the rs1800890, rs1800871 and rs1800872 had no association with NHL risk. Among the common subtypes of NHL, three polymorphisms (rs1800890, rs1800896 and rs1800872) had significant association with DLBCL risk.

Dai, Zhi-Ming; He, Ai-Li; Zhang, Wang-Gang; Liu, Jie; Cao, Xing-Mei; Chen, Yin-Xia; Ma, Xiao-Rong; Zhao, Wan-Hong; Dai, Zhi-Jun

2014-01-01

115

Evolutionary insights about bacterial GlxRS from whole genome analyses: is GluRS2 a chimera?  

PubMed Central

Background Evolutionary histories of glutamyl-tRNA synthetase (GluRS) and glutaminyl-tRNA synthetase (GlnRS) in bacteria are convoluted. After the divergence of eubacteria and eukarya, bacterial GluRS glutamylated both tRNAGln and tRNAGlu until GlnRS appeared by horizontal gene transfer (HGT) from eukaryotes or a duplicate copy of GluRS (GluRS2) that only glutamylates tRNAGln appeared. The current understanding is based on limited sequence data and not always compatible with available experimental results. In particular, the origin of GluRS2 is poorly understood. Results A large database of bacterial GluRS, GlnRS, tRNAGln and the trimeric aminoacyl-tRNA-dependent amidotransferase (gatCAB), constructed from whole genomes by functionally annotating and classifying these enzymes according to their mutual presence and absence in the genome, was analyzed. Phylogenetic analyses showed that the catalytic and the anticodon-binding domains of functional GluRS2 (as in Helicobacter pylori) were independently acquired from evolutionarily distant hosts by HGT. Non-functional GluRS2 (as in Thermotoga maritima), on the other hand, was found to contain an anticodon-binding domain appended to a gene-duplicated catalytic domain. Several genomes were found to possess both GluRS2 and GlnRS, even though they share the common function of aminoacylating tRNAGln. GlnRS was widely distributed among bacterial phyla and although phylogenetic analyses confirmed the origin of most bacterial GlnRS to be through a single HGT from eukarya, many GlnRS sequences also appeared with evolutionarily distant phyla in phylogenetic tree. A GlnRS pseudogene could be identified in Sorangium cellulosum. Conclusions Our analysis broadens the current understanding of bacterial GlxRS evolution and highlights the idiosyncratic evolution of GluRS2. Specifically we show that: i) GluRS2 is a chimera of mismatching catalytic and anticodon-binding domains, ii) the appearance of GlnRS and GluRS2 in a single bacterial genome indicating that the evolutionary histories of the two enzymes are distinct, iii) GlnRS is more widespread in bacteria than is believed, iv) bacterial GlnRS appeared both by HGT from eukarya and intra-bacterial HGT, v) presence of GlnRS pseudogene shows that many bacteria could not retain the newly acquired eukaryal GlnRS. The functional annotation of GluRS, without recourse to experiments, performed in this work, demonstrates the inherent and unique advantages of using whole genome over isolated sequence databases. PMID:24521160

2014-01-01

116

Mr. R.'s World of Math  

NSDL National Science Digital Library

Mr. R.'s World of Math is a teacher-created collection of math videos, poems, stories, songs, and challenges to help students master basic math functions. In addition to videos there are printable student handouts for the math challenges and several powerpoint demonstrations.

117

Activated DDR1 increases RS cell survival.  

PubMed

In this issue of Blood, Cader et al show that tumor microenvironment promotes Epstein-Barr virus (EBV)-driven lymphomagenesis in Hodgkin lymphoma by a novel pathway involving latent membrane protein 1 (LMP1) and discoidin domain receptor 1 (DDR1), which is activated by collagen(s) and contributes to the survival of Reed-Sternberg (RS) cells. PMID:24357706

Carbone, Antonino; Gloghini, Annunziata

2013-12-19

118

The resonance line of B II in IUE spectra of chemically peculiar stars  

NASA Technical Reports Server (NTRS)

A description is presented of high-dispersion spectroscopic observations of eight chemically peculiar stars including Kappa Cnc and Mu Lep, and of one normal comparison star, Nu Cap, in the vicinity of 1362 A. The reported data were obtained with the International Ultraviolet Explorer during the first 15 months of its operation. The initial reduction of the data, which were originally described in a qualitative summary by Leckrone (1980), was affected by a serious error in the calibration of the instrument's intensity transfer function. This error has been corrected in the currently presented data. The results of spectrum syntheses of the 1362 A feature are also described for several of the stars.

Leckrone, D. S.

1981-01-01

119

Design Of An On-Line Diagnostic System Of Finished Surfaces In An Automated Mechanized Process By CNC Turning  

Microsoft Academic Search

The primary aim of this study was to design and develop an on-line diagnostic system for the real-time prediction of finished surfaces (Ra) in automated mechanized process by turning CNC. In the first phase the characterization parameters of cutting-force signals (Fx, Fy, Fz) in the time and the frequency domain were assessed. Thereafter, the parameters that significantly influence finished surfaces

E. García-Plaza; P. J. Núñez; A. R. Martín; R. Trujillo; C. de La Cruz

2009-01-01

120

Optical and X-ray studies of chromospherically active stars: FR Cancri, HD 95559 and LO Pegasi  

NASA Technical Reports Server (NTRS)

We present a multiwavelength study of three chromospherically active stars, namely FR Cnc (= BD +16 degrees 1753), HD 95559 and LO Peg (=BD +22 degrees 4409), including newly obtained optical photometry, (for FR Cnc) low-resolution optical spectroscopy, as well as archival IR and X-ray observations. The BVR photometry carried out during the years 2001 - 2004 has found significant photometric variability to be present in all three stars. For FR Cnc, a photometric period 0.826685 +/- 0.000034 d has been established. The strong variation in the phase and amplitude of the FR Cnc light curves when folded on this period implies the presence of evolving and migrating spots or spot groups on its surface. Two independent spots with migration periods of 0.97 and 0.93 years respectively are inferred. The photometry of HD 95559 suggests the formation of a spot (group) during the interval of our observations. We infer the existence of two independent spots or groups in the photosphere of LO Peg, one of which has a migration period of 1.12 years. The optical spectroscopy of FR Cnc carried out during 2002-2003, reveals the presence of strong and variable Ca I1 H and K, H(sub beta) and H(sub alpha) emission features indicative of high level of chromospheric activity. The value of 5.3 for the ratio of the excess emission in H(sub alpha) to H(sub beta), EH(sub alpha)/EH(sub beta), suggests that the chromospheric emission may arise from an extended off-limb region. We have searched for the presence of color excesses in the near-IR JHK bands of these stars using 2MASS data, but none of them appear to have any significant color excess. We have also analyzed archival X-ray observations of HD 95559 and LO Peg carried out by with the ROSAT observatory. The best fit models to their X-ray spectra imply the presence of two coronal plasma components of differing temperatures and with sub-solar metal abundances. The inferred emission measures and temperatures of these systems are similar to those found for other active dwarf stars. The kinematics of FR Cnc suggest that it is a very young (35 - 55 Myrs) main-sequence star and a possible member of the IC 2391 supercluster. LO Peg also has young disk-type kinematics and has been previously suggested to be a member of the 100 Mys old Local Association (Pleiades Moving Group). The kinematics of HD 95559 indicate it is a possible member of the 600 Myrs old Hyades supercluster.

Pandey, J. C.; Singh, K. P.; Drake, S. A.; Sagar, R.

2005-01-01

121

Oldenlandia affinis (R&S) DC  

Microsoft Academic Search

A review of the geographical distribution, clinical use, biological activity and phytochemistry of Oldenlandia affinis (R&S) DC. is presented. During an inventory of medicinal plants in northern Congo\\/Brazzaville and south-western Central African Republic in 1962, 196 different species were registered, one of which was O. affinis used for the facilitation of childbirth. A medical team working in Luluabourg (Kananga) in

Lorents Gran; Finn Sandberg; Knut Sletten

2000-01-01

122

An adaptive recurrent-neural-network motion controller for X-Y table in CNC machine.  

PubMed

In this paper, an adaptive recurrent-neural-network (ARNN) motion control system for a biaxial motion mechanism driven by two field-oriented control permanent magnet synchronous motors (PMSMs) in the computer numerical control (CNC) machine is proposed. In the proposed ARNN control system, a RNN with accurate approximation capability is employed to approximate an unknown dynamic function, and the adaptive learning algorithms that can learn the parameters of the RNN on line are derived using Lyapunov stability theorem. Moreover, a robust controller is proposed to confront the uncertainties including approximation error, optimal parameter vectors, higher-order terms in Taylor series, external disturbances, cross-coupled interference and friction torque of the system. To relax the requirement for the value of lumped uncertainty in the robust controller, an adaptive lumped uncertainty estimation law is investigated. Using the proposed control, the position tracking performance is substantially improved and the robustness to uncertainties including cross-coupled interference and friction torque can be obtained as well. Finally, some experimental results of the tracking of various reference contours demonstrate the validity of the proposed design for practical applications. PMID:16602590

Lin, Faa-Jeng; Shieh, Hsin-Jang; Shieh, Po-Huang; Shen, Po-Hung

2006-04-01

123

A Super-Earth Transiting a Naked-eye Star  

NASA Astrophysics Data System (ADS)

We have detected transits of the innermost planet "e" orbiting 55 Cnc (V = 6.0), based on two weeks of nearly continuous photometric monitoring with the MOST space telescope. The transits occur with the period (0.74 days) and phase that had been predicted by Dawson & Fabrycky, and with the expected duration and depth for the crossing of a Sun-like star by a hot super-Earth. Assuming the star's mass and radius to be 0.963+0.051 - 0.029 M sun and 0.943 ± 0.010 R sun, the planet's mass, radius, and mean density are 8.63 ± 0.35 M ?, 2.00 ± 0.14 R ?, and 5.9+1.5 - 1.1 g cm-3, respectively. The mean density is comparable to that of Earth, despite the greater mass and consequently greater compression of the interior of 55 Cnc e. This suggests a rock-iron composition supplemented by a significant mass of water, gas, or other light elements. Outside of transits, we detected a sinusoidal signal resembling the expected signal due to the changing illuminated phase of the planet, but with a full range (168 ± 70 ppm) too large to be reflected light or thermal emission. This signal has no straightforward interpretation and should be checked with further observations. The host star of 55 Cnc e is brighter than that of any other known transiting planet, which will facilitate future investigations. Based on data from the MOST satellite, a Canadian Space Agency mission, jointly operated by Dynacon Inc., the University of Toronto Institute for Aerospace Studies, and the University of British Columbia, with the assistance of the University of Vienna.

Winn, Joshua N.; Matthews, Jaymie M.; Dawson, Rebekah I.; Fabrycky, Daniel; Holman, Matthew J.; Kallinger, Thomas; Kuschnig, Rainer; Sasselov, Dimitar; Dragomir, Diana; Guenther, David B.; Moffat, Anthony F. J.; Rowe, Jason F.; Rucinski, Slavek; Weiss, Werner W.

2011-08-01

124

An Analysis of Light Variations of RS Canum Venaticorum Binary Systems.  

NASA Astrophysics Data System (ADS)

Photoelectric data for fourteen RS Canum Venaticorum binary systems were obtained by the author from 1978 through 1981, at Rosemary Hill Observatory. These data are presented in the form of light curves and tabulated magnitudes and heliocentric Julian Dates. The outside-of-eclipse points for eight systems were Fourier analyzed for measurement of any distortion wave in the light curve. The wave in RS Canum Venaticorum itself was found to have moved half a phase unit in only two years. A wave was discovered in the light curve of RZ Eridani, and was found to have changed in a manner consistent with the starspot model for RS CVn systems. The light curve for UX Comae Bernices was found to have a large amount of intrinsic scatter, and the system was found to be anomalously bright on one night. These characteristics suggest that some type of flare activity may be present in that system. The other five systems analyzed were found to have waves consistent with other published results, or to have no definite wave at all. The possibility of detecting spots and deriving spot sizes from secondary eclipse observations was also explored. For this purpose the Wilson-Devinney computer program for light curve synthesis was modified to allow spots on the secondary star. Comparison of computer synthesized secondary eclipses of spotted stars to actual observations showed that there is little chance of detecting fluctuations due to individual spots. It was found that there is even less chance for discriminating between a few large spots and a large number of smaller spots. However, the program did produce good fits to RS CVn light curves, using reasonable spot parameters.

Caton, Daniel Bruce

125

Interferometer observations of RS Canum Venaticorum binaries  

NASA Astrophysics Data System (ADS)

We present radio flux measurements at 5 GHz for a sample of RS CVn-type chromospherically active binary systems made from 1988 to 1992 using the Nuffield Radio Astronomy Laboratories (NRAL) broad-band interferometer (BBI). The derived radio luminosities are consistent with previous observations but show that radio flaring is a common feature which will effect the results of rotation-activity studies. The mean brightness temperature for our sample, assuming a radio source size equal to twice the radius of the active stellar component, is consistent with a gyrosynchrotron emission process from mildly relativistic electrons.

Gunn, A. G.; Spencer, R. E.; Abdul Aziz, H.; Doyle, J. G.; Davis, R. J.; Pavelin, P. E.

1994-11-01

126

RADIAL VELOCITY PLANETS DE-ALIASED: A NEW, SHORT PERIOD FOR SUPER-EARTH 55 Cnc e  

SciTech Connect

Radial velocity measurements of stellar reflex motion have revealed many extrasolar planets, but gaps in the observations produce aliases, spurious frequencies that are frequently confused with the planets' orbital frequencies. In the case of Gl 581 d, the distinction between an alias and the true frequency was the distinction between a frozen, dead planet and a planet possibly hospitable to life. To improve the characterization of planetary systems, we describe how aliases originate and present a new approach for distinguishing between orbital frequencies and their aliases. Our approach harnesses features in the spectral window function to compare the amplitude and phase of predicted aliases with peaks present in the data. We apply it to confirm prior alias distinctions for the planets GJ 876 d and HD 75898 b. We find that the true periods of Gl 581 d and HD 73526 b/c remain ambiguous. We revise the periods of HD 156668 b and 55 Cnc e, which were afflicted by daily aliases. For HD 156668 b, the correct period is 1.2699 days and the minimum mass is (3.1 {+-} 0.4) M{sub +}. For 55 Cnc e, the correct period is 0.7365 days-the shortest of any known planet-and the minimum mass is (8.3 {+-} 0.3) M{sub +}. This revision produces a significantly improved five-planet Keplerian fit for 55 Cnc, and a self-consistent dynamical fit describes the data just as well. As radial velocity techniques push to ever-smaller planets, often found in systems of multiple planets, distinguishing true periods from aliases will become increasingly important.

Dawson, Rebekah I.; Fabrycky, Daniel C., E-mail: rdawson@cfa.harvard.ed, E-mail: daniel.fabrycky@gmail.co [Harvard-Smithsonian Center for Astrophysics, 60 Garden St., MS-10, Cambridge, MA 02138 (United States)

2010-10-10

127

A plausible third body in RS CVn-type binary: RT Coronae Borealis  

NASA Astrophysics Data System (ADS)

Cyclic period changes, which are usually explained as being caused by the magnetic activity of one or both components or the light travel time effect of a third body, are a typical phenomenon in the RS CVn-type binary. Combining the newly determined eclipsing times with others compiled from literature, we analyzed the cyclic period change in the RS CVn-type binary RT CrB. The result shows that the orbital period of the binary shows a period of 3.47 yr with an amplitude of 0 d .0084. The cyclic oscillation can be attributed to the existence of a third body with a lower limit mass of 1.71(±0.19) M ?. The third body is cycling the binary at a distance of no more than 2.30(±0.19) AU which would play an important role in the evolution of this system. No detected spectral lines of the third body may suggest that the third component may itself be a close binary of 0.86 M ? stars, or more likely a dark star such as a neutron star.

Zhang, W. X.; Ran, M. W.; Feng, Y. G.

2014-12-01

128

Effect of a gelatin-based edible coating containing cellulose nanocrystals (CNC) on the quality and nutrient retention of fresh strawberries during storage  

NASA Astrophysics Data System (ADS)

Strawberry is a non-climacteric fruit with a very short postharvest shelf-life. Loss of quality in this fruit is mostly due to its relatively high metabolic activity and sensitivity to fungal decay, meanly grey mold (Botrytis cinerea). In this study, the ability of gelatin coatings containing cellulose nanocrystals (CNC) to extend the shelf-life of strawberry fruit (Fragaria ananassa) over 8 days were studied. The filmogenic solution was obtained by the hydration of 5 g of gelatin (GEL) in 100 mL of distillated water containing different amounts of CNC dispersion (10 mg CNC/g of GEL or 50 mg of CNC/g of GEL) for 1 hour at room temperature. After this period, the solution was heated to 70 °C and maintained at this temperature for 10 minutes. The plasticizer (glycerol) (10g/100g of the GEL) was then added with constant, gentle stirring in order to avoid forming air bubbles and also to avoid gelatin denaturation until complete homogenization. Strawberries (purchased at the local market) were immersed in the filmogenic solution for 1 minute and after coated were dried at 15 °C by 24 hours. The strawberries were then kept under refrigeration and characterized in terms of their properties (weight loss, ascorbic acid content, titratable acidity, water content). The results have shown that samples covered with GEL/CNC had a significant improvement in its shelf- life. For instance, for the control sample (without coating) the weight loss after 8 days of storage was around 65%, while covered samples loss in the range of 31-36%. Edible coating was also effective in the retention of ascorbic acid (AA) in the strawberries, while control sample presented a fast decay in the AA content, covered samples showed a slow decay in the AA concentration. Moreover, the use of GEL/CNC edible coating had an antimicrobial effect in the fruits.

Fakhouri, F. M.; Casari, A. C. A.; Mariano, M.; Yamashita, F.; Innocnentini Mei, L. H.; Soldi, V.; Martelli, S. M.

2014-08-01

129

High-Speed RaPToRS  

NASA Astrophysics Data System (ADS)

The High-Speed Rapid Pneumatic Transport of Radioactive Samples (HS-RaPToRS) system, designed to quickly and safely move radioactive materials, was assembled and tested at the Mercury facility of the Naval Research Laboratory (NRL) in Washington D.C. A sample, which is placed inside a four-inch-diameter carrier, is activated before being transported through a PVC tube via airflow. The carrier travels from the reaction chamber to the end station where it pneumatically brakes prior to the gate. A magnetic latch releases the gate when the carrier arrives and comes to rest. The airflow, optical carrier-monitoring devices, and end gate are controlled manually or automatically with LabView software. The installation and testing of the RaPToRS system at NRL was successfully completed with transport times of less than 3 seconds. The speed of the carrier averaged 16 m/s. Prospective facilities for similar systems include the Laboratory for Laser Energetics and the National Ignition Facility.

Henchen, Robert; Esham, Benjamin; Becker, William; Pogozelski, Edward; Padalino, Stephen; Sangster, Thomas; Glebov, Vladimir

2008-11-01

130

The ROSAT All-Sky Survey of active binary coronae. I - Quiescent fluxes for the RS Canum Venaticorum systems  

NASA Astrophysics Data System (ADS)

One hundred and thirty-six RS CV(n) active binary systems were observed with the ROSAT Position Sensitive Proportional Counter (PSPC) during the All-Sky Survey component of the mission. The entire sky was surveyed, which represents the largest sample of RS CV(n) systems observed to date at any wavelength, including X-rays. X-ray surface fluxes for the RS CV(n) systems are found to lie in the range 10 exp 4 to 10 exp 8 ergs/sq cm seconds. Surface flux as a function of (B - V) color is reported. A decrease in surface flux with increasing rotation period for the entire sample is observed. The rotation period provides the best stellar or orbital parameter to predict the X-ray surface flux level. The absence of correlation of F(x) or L(x) with Gamma is noted due to the fact that the coronal heating mechanism for these active stars must be magnetic in character, and the magnetic field depends on the interaction between convection and differential rotation inside the star. X-ray properties of the RS CV(n) systems with 6 cm radio and C IV UV emission systems is compared.

Dempsey, Robert C.; Linsky, Jeffrey L.; Fleming, Thomas A.; Schmitt, J. H. M. M.

1993-06-01

131

RS-170 to 700 frame-per-second CCD camera  

NASA Astrophysics Data System (ADS)

A versatile new camera, the Los Alamos National Laboratory (LANL) model GY6, is described. It operates at a wide variety of frame rates, from RS-170 to 700 frames per second. The camera operates as an NTSC compatible black and white camera when operating at RS- 170 rates. When used for variable high-frame rates, a simple substitution is made of the RS- 170 sync/clock generator circuit card with a high speed emitter-coupled logic (ECL) circuit card.

Albright, Kevin L.; King, Nicholas S. P.; Yates, George J.; McDonald, Thomas E.; Turko, Bojan T.

1993-10-01

132

An RS-170 to 700 frame per second CCD camera  

SciTech Connect

A versatile new camera, the Los Alamos National Laboratory (LANL) model GY6, is described. It operates at a wide variety of frame rates, from RS-170 to 700 frames per second. The camera operates as an NTSC compatible black and white camera when operating at RS-170 rates. When used for variable high-frame rates, a simple substitution is made of the RS-170 sync/clock generator circuit card with a high speed emitter-coupled logic (ECL) circuit card.

Albright, K.L.; King, N.S.P.; Yates, G.J.; McDonald, T.E. [Los Alamos National Lab., NM (United States); Turko, B.T. [Lawrence Berkeley Lab., CA (United States)

1993-08-01

133

Remastering the RV Classics: Self-Consistent Dynamical Models for the 55 Cnc and GJ 876 Planetary Systems  

NASA Astrophysics Data System (ADS)

Over the past two decades, radial velocity (RV) observations have uncovered a handful of dynamically rich exoplanet systems. In particular, the 55 Cnc and GJ 876 systems have 4+ planets with some of them displaying planet-planet interactions on the observing timescale. In turn, this makes the posterior distributions of these systems oddly shaped and extremely difficult to sample from, especially when employing a Newtonian model. We apply our Radial velocity Using N-body Differential evolution Markov chain Monte Carlo code (RUN DMC; Nelson et al. 2013, submitted) to these two landmark systems. For 55 Cnc, we investigate the orbital architecture based on a cumulative 1418 RV observations from various sources and transit constraints from Winn et al. 2011. We find planets "b" and "c" are apsidally aligned but not in a mean-motion resonance, and the orbital stability of the system is sensitive to the orbital properties of planet "f". For GJ 876, we analyze the Keck HIRES (Rivera et al. 2010) and HARPS (Correia et al. 2010) data to constrain the distribution of the Laplace argument and mutual inclinations amongst planet pairs based on both the RVs and assumption of long-term stability.

Nelson, Benjamin E.; Ford, E. B.; Wright, J.; Fischer, D.

2014-01-01

134

Circumstellar Dust Disks around Stars with Known Planetary Companions  

NASA Astrophysics Data System (ADS)

We have searched six stars with known radial velocity planetary companions for circumstellar disks. Disks are expected around stars with planetary systems that accreted from regular protoplanetary disks, and remnant disks are expected to be similar to our solar system's Kuiper Belt. To date, we have detected circumstellar disks around three such stars: 55 Cnc, ? CrB, and HD 210277. All these systems now resemble mature planetary systems with Jupiter-mass companions and Kuiper Belt-like disks. Our previous detection of the 55 Cnc disk (Trilling & Brown) is included here to place that disk in the context of the other two newly detected disks. Measuring the inclinations of the disks and assuming the disks are coplanar with the planets' orbits determines the masses of the planets around these three stars to be 1.9+1.1-0.4 MJ, 1.5+0.2-0.1 MJ, and 2.2+0.6-0.2 MJ, respectively (1 MJ is one Jupiter mass). We also report nondetections for three stars--51 Peg, ? And, and Gl876--that are known to have radial velocity companions. A number of possibilities exist to explain nondetections of disks, from the absence of a disk to limits on disk mass, radial extent, or inclination. We may also be looking through a disk's central hole, especially for the nearby star Gl876. The radial brightness profiles of each of the observed disks follow a power law with index ~-5, including a power of -2 from the stellar flux drop off, similar to the suggested value for our solar system's Kuiper Belt. This likely suggests that uniform physical processes govern the Kuiper Belt's population out to at least 100 AU, and may be ubiquitous among disks. Last, we discuss how disk characterizations can lead us toward refining theories of planetary system formation.

Trilling, D. E.; Brown, R. H.; Rivkin, A. S.

2000-01-01

135

Genetic variations rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population.  

PubMed

Genome-wide association studies (GWAS) have identified a number of genetic variants associated with risk of bladder cancer in populations of European descent. Here, we assessed association of two of these variants, rs11892031 (2q37.1 region) and rs401681 (5p15.33 region) in a Chinese case-control study, which included 367 bladder cancer cases and 420 controls. We found that the AC genotype of rs11892031 was associated with remarkably decreased risk of bladder cancer (adjusted odds ratio (OR), 0.27; 95% confidence interval (CI), 0.09-0.81; p=0.019), compared with the AA genotype of rs11892031; and that CT/CC genotypes of rs401681 were associated with significantly increased risk of bladder cancer (adjusted OR, 1.79; 95% CI, 1.10-2.91; p=0.02), compared with the TT genotype of rs401681. We further conducted stratification analysis to examine the correlation between single nucleotide polymorphism (SNP) rs11892031/rs401681 and tumor grade/stage. Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p>0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population. The present study suggests that the SNPs rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population. Future analyses will be conducted with more participants recruited in a case-control study. PMID:25347272

Zhang, Yu; Sun, Yan; Chen, Tao; Hu, Hailong; Xie, Wanqin; Qiao, Zhihui; Ding, Na; Xie, Linguo; Li, Sheng; Wang, Wenlong; Xing, Chen; Wang, Yihan; Qie, Yunkai; Wu, Changli

2014-01-01

136

A Search for wide visual companions of exoplanet host stars - The Calar Alto Survey  

E-print Network

We have carried out a search for co-moving stellar and substellar companions around 18 exoplanet host stars with the infrared camera MAGIC at the 2.2m Calar Alto telescope, by comparing our images with images from the all sky surveys 2MASS, POSS I and II. Four stars of the sample namely HD80606, 55Cnc, HD46375 and BD-103166, are listed as binaries in the Washington Visual Double Star Catalogue (WDS). The binary nature of HD80606, 55Cnc, and HD46375 is confirmed with both astrometry as well as photometry, thereby the proper motion of the companion of HD46375 was determined here for the first time. We derived the companion masses as well as the longterm stability regions for additional companions in these three binary systems. We can rule out further stellar companions around all stars in the sample with projected separations between 270AU and 2500AU, being sensitive to substellar companions with masses down to \\~60MJup (S/N=3). Furthermore we present evidence that the two components of the WDS binary BD-103166 are unrelated stars, i.e this system is a visual pair. The spectrophotometric distance of the primary (a K0 dwarf) is ~67pc, whereas the presumable secondary BD-103166B (a M4 to M5 dwarf) is located at a distance of 13pc in the foreground.

Markus Mugrauer; R. Neuhaeuser; T. Mazeh; E. Guenther; M. Fernandez; C. Broeg

2006-02-03

137

An X-ray-emitting blast wave from the recurrent nova RS Ophiuchi.  

PubMed

Stellar explosions such as novae and supernovae produce most of the heavy elements in the Universe. The onset of a nova is well understood as driven by runaway thermonuclear fusion reactions on the surface of a white dwarf in a binary star system; but the structure, dynamics and mass of the ejecta are not well known. In rare cases, the white dwarf is embedded in the wind nebula of a red-giant companion, and the explosion products plough through the nebula and produce X-ray emission. Here we report X-ray observations of such an event, from the eruption of the recurrent nova RS Ophiuchi. The hard X-ray emission from RS Ophiuchi early in the eruption emanates from behind a blast wave, or outward-moving shock wave, that expanded freely for less than 2 days and then decelerated owing to interaction with the nebula. The X-rays faded rapidly, suggesting that the blast wave deviates from the standard spherical shell structure. The early onset of deceleration indicates that the ejected shell had a low mass, the white dwarf has a high mass, and that RS Ophiuchi is therefore a progenitor of the type of supernova (type Ia) integral to studies of the expansion of the Universe. PMID:16855584

Sokoloski, J L; Luna, G J M; Mukai, K; Kenyon, Scott J

2006-07-20

138

Cloning and heterologous expression of the ftfCNC-2(1) gene from Weissella confusa MBFCNC-2(1) as an extracellular active fructansucrase in Bacillus subtilis.  

PubMed

Fructan-exopolysaccharides (fructan-EPS) (inulin and levan) and their oligosaccharides (fructooligosaccharides, FOS) have drawn considerable interest in the food and pharmaceutical industries. EPS-producing lactic acid bacteria have been reported to produce ?-fructans (inulin and levan), as well as ?-glucans, by the function of sucrase enzymes, i.e., fructansucrase and glucansucrase. A fructansucrase ftfCNC-2(1) gene from Weissella confusa strain MBFCNC-2(1) was previously cloned in Escherichia coli. In this study, we aimed to express the ftf[CNC-2(1)] gene in Bacillus subtilis to obtain the active form of the extracellular recombinant protein FTF[CNC-2(1)]. This cloning was achieved by inserting the gene in-fusion with the signal sequence of the B. subtilis subtilisin E. SDS-polyacrylamide gel electrophoresis analysis and in situ activity assay with Periodic Acid-Schiff staining revealed that the recombinant FTF[CNC-2(1)] was successfully expressed as an extracellular protein from B. subtilis DB403 in its active form, which was confirmed using sucrose and raffinose. PMID:25454699

Malik, Amarila; Hapsari, Maria Tyas; Ohtsu, Iwao; Ishikawa, Shu; Takagi, Hiroshi

2014-10-29

139

57ime CONGRS CANADIEN DE GOTECHNIQUE 57TH CANADIAN GEOTECHNICAL CONFERENCE 5ime CONGRS CONJOINT SCG/AIH-CNN 5TH JOINT CGS/IAH-CNC CONFERENCE  

E-print Network

CONJOINT SCG/AIH-CNN 5TH JOINT CGS/IAH-CNC CONFERENCE SIMULATING ACID MINE DRAINAGE THROUGH MINE WASTES Québec ABSTRACT The evolution of acid mine drainage (AMD) from reactive mine wastes is simulated using that sulphide oxidation and acid mine drainage can be significantly reduced using capillary barriers

Aubertin, Michel

140

1.4 Cellulose Nanocrystals as a Reinforcing Phase in Composite Structures Spatially Resolved Characterization of CNC-Polypropylene Composite by Confocal Raman Microscopy  

E-print Network

Abstract. Raman spectroscopy was used to analyze cellulose nanocrystal (CNC)-polypropylene (PP) composites and to investigate the spatial distribution of CNCs in extruded composite filaments. Three composites were made from two forms of nanocellulose (CNCs from wood pulp and the nanoscale fraction of microcrystalline cellulose), and two of the three composites investigated used maleated PP as a coupling agent. Raman maps based on cellulose and PP bands at 1098 and 1460 cm-1 respectively and obtained at 1 micron spatial resolution showed that the CNCs were aggregated to various degrees in the PP matrix. Of the three composites analyzed, two showed clear existence of phase-separated regions: Raman images with strong PP and absent cellulose, or vice versa. For the third composite, the situation was slightly improved, but a clear transition interface between the PP-abundant and CNC-abundant regions was observed, indicating that the CNC remained poorly dispersed. The spectroscopic approach to investigating spatial distribution of composite components was helpful in evaluating CNC dispersion in the composite at the microscopic level, which helped explain the relatively modest reinforcement of PP by CNCs.

Umesh Agarwal; Ronald Sabo; Craig Clemons; Alan Rudie

141

Ionization Models of Symbiotic Stars  

NASA Astrophysics Data System (ADS)

A model of a symbiotic system is outlined. The author presents evidence that the main ionization mechanism responsible for the symbiotic nebula is radiative and not collisional. If the ionizing radiation is due to accretion, the boundary layer between accreting star and disc provides the bulk of the ionizing photons. The possibility for distinguishing between different ionization sources are briefly discussed. C/N and O/N abundance ratios, calculated with the outlined ionization model places HM Sge, RS Oph, and T CrB among the novae and not among the symbiotic stars.

Nussbaumer, H.

142

Fast decoding of a d(min) = 6 RS code  

NASA Technical Reports Server (NTRS)

A method for high speed decoding a d sub min = 6 Reed-Solomon (RS) code is presented. Properties of the two byte error correcting and three byte error detecting RS code are discussed. Decoding using a quadratic equation is shown. Theorems and concomitant proofs are included to substantiate this decoding method.

Deng, H.; Costello, D. J., Jr.

1983-01-01

143

Two distinct subtypes of human respiratory syncytial (RS) virus  

Microsoft Academic Search

SUMMARY Antigenic variation of human respiratory syncytial (RS) virus strains was analysed using a collection of nine, six, six, nine and one monoclonal antibodies respectively directed against the large glycoprotein (G), fusion protein (F), matrix protein (M), nucleoprotein (NP) and phosphoprotein (P) components of the Long strain of RS virus. A comparison was made with seven other strains isolated during

MAURICE A. MUFSON; CLAES ORVELL; BJORG RAFNAR; ERLING NORRBY

1985-01-01

144

Metallicity and effective temperature of the secondary of RS Ophiuchi  

Microsoft Academic Search

Context: The recurrent nova RS Ophiuchi undergoes nova eruptions every ~10-20 years as a result of thermonuclear runaway on the surface of a white dwarf close to the Chandrasekhar limit. Both the progress of the eruption and its aftermath depend on the (poorly known) composition of the red giant in the RS Oph system. Aims: Our aim is to understand

Ya. V. Pavlenko; A. Evans; T. Kerr; L. Yakovina; C. E. Woodward; D. Lynch; R. Rudy; R. L. Pearson; R. W. Russell

2008-01-01

145

Association of BID SNPs (rs8190315 and rs2072392) and clinical features of benign prostate hyperplasia in Korean population  

PubMed Central

Exercise has beneficial effect on cancer apoptosis and benign prostatic hyperplasia (BPH). The BH3 interacting domain death agonist (BID) gene expression is associated with apoptosis or cell proliferation. In this study, we investigated the association between BID single nucleotide polymorphisms (SNPs) and the development, prostate volume, and international prostate symptom score (IPSS) of BPH. In 222 BPH males and 214 controls, two SNPs in BID [rs8190315 (Ser56Gly), and rs2072392 (Asp106Asp)] were genotyped and analyzed using multiple logistic regression models. In the result, the genotype and allele frequencies of rs8190315 and rs2072392 were not associated with BPH development or IPSS, however, the allele frequencies [odd ratio (OR)= 1.90, 95% confidence interval (CI)= 1.07–3.41, P= 0.03] and genotype frequencies (in dominant model, OR= 1.94, 95% CI= 1.01–3.74, P= 0.42) of rs8190315, and the genotype frequencies of rs2072392 (in dominant model, OR= 1.94, 95% CI= 1.01–3.74, P= 0.42) were associated with increased prostate volume. We propose that rs8190315 and rs2072392 of BID may contribute to the disease severity of BPH. PMID:25610824

Seok, Hosik; Kim, Su Kang; Yoo, Koo Han; Lee, Byung-Cheol; Kim, Young Ock; Chung, Joo-Ho

2014-01-01

146

The evolution of the Three Rs.  

PubMed

Whilst the whole world is celebrating the bicentenary of the birth of Charles Darwin and the 150th anniversary of the publication of his renowned book, The Origin of Species, another anniversary should not be forgotten - the publication of The Principles of Humane Experimental Technique by W.M.S. Russell and R.L. Burch. The concomitance of the anniversaries of the two publications is not a coincidence, since, as reflected by the numerous quotes chosen by Russell from Darwin's masterpiece, numerous analogies can be found between the two works and the new ideas they describe. From a discrete birth, and after decades of struggle, the Three Rs concept can now celebrate its 50th anniversary, the result of its evolution through harsh selection and adaptation. The emergence of new types of techniques, in combination with the descent of modified old ones, testify to the undeniable change in our society toward a more efficient and more ethical science, through the progressive replacement of animal models. Both Darwin and Russell would no doubt have welcomed such progress, not only in terms of science, but also of moral values. One could also expect that, if Russell could have foreseen the incredible technological advances achieved 50 years later, where Replacement becomes a reality, as illustrated by some edifying examples, The Principles of Humane Experimental Technique would have probably been defined as the One R concept. PMID:19678725

Farnaud, Sebastien

2009-07-01

147

Design Of An On-Line Diagnostic System Of Finished Surfaces In An Automated Mechanized Process By CNC Turning  

NASA Astrophysics Data System (ADS)

The primary aim of this study was to design and develop an on-line diagnostic system for the real-time prediction of finished surfaces (Ra) in automated mechanized process by turning CNC. In the first phase the characterization parameters of cutting-force signals (Fx, Fy, Fz) in the time and the frequency domain were assessed. Thereafter, the parameters that significantly influence finished surfaces and underpin predicted models based on regression techniques have been evaluated. The global monitoring system was developed with the Dasylab 9.0 (Labview family) that enables: the visual display of data; signal acquisition, processing and analysis; and the real-time prediction of finished surfaces (Ra). Thus, the system predicts the Ra parameter with a relative error percentage below 5.8%, which is similar to the precision obtained in post-process quality control using a stylus contact profilometer.

García-Plaza, E.; Núñez, P. J.; Martín, A. R.; Trujillo, R.; De la Cruz, C.

2009-11-01

148

Leukocyte Telomere Length-Related rs621559 and rs398652 Genetic Variants Influence Risk of HBV-Related Hepatocellular Carcinoma  

PubMed Central

Recent genome-wide association studies (GWAS) have identified eleven leukocyte telomere length (LTL)-related single nucleotide polymorphisms (SNPs). Since LTL has been associated with risk of many malignancies, LTL-related SNPs may contribute to cancer susceptibility. To test this hypothesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we genotyped these eleven LTL-related SNPs in a case-control set including 1186 HBV-related HCC cases, 508 chronic HBV carriers and 1308 healthy controls at the discovery stage. The associations of HCC risk with these SNPs were further confirmed in an independent case-control set. We found that 1p34.2 rs621559 and 14q21 rs398652 were significantly associated with HBV-related HCC risk (both P<0.005 after Bonferroni corrections). There was no significant difference of either rs621559 or rs398652 genotypes between chronic HBV carriers and healthy controls, demonstrating that the association was not due to predisposition to HBV infection. In the pooled analyses (1806 HBV-related HCC cases and 1954 controls), we observed a decreased HCC risk, 0.72-times, associated with the 1p34.2 rs621559 AA genotype compared to the GG genotype (P?=?1.6×10?6). Additionally, there was an increased HCC risk, 1.27-fold, associated with the rs398652 GG genotype (P?=?3.3×10?6). A statistical joint effect between the rs621559 GG and rs398652 GG genotypes may exist in elevating risk of HBV-related HCC. We show, for the first time, that rs398652 and rs621559 might be marker genetic variants for risk of HBV-related HCC in the Chinese population. PMID:25365256

Shi, Juan; Lu, Chao; Wei, Jinyu; Li, Lichao; Zhou, Changchun; Yuan, Qipeng; Zhou, Liqing; Yang, Ming

2014-01-01

149

A study of short-period RS Canum Venaticorum and W Ursae Majoris binary systems - The global nature of H-alpha  

NASA Astrophysics Data System (ADS)

The author presents the rotation versus emission characteristics of the H? line for several short-period (P ? 1d) RS CVn and W UMa binary systems. Estimates for the chromospheric emission arising from each component star were obtained by subtraction of "nonactive" model spectra constructed from comparison stars. Enhanced H? emission compared to the nonactive comparison stars is seen on all components of the short-period RS CVn systems studied, while a similar enhancement is only typically seen on the primary components of the W-type W UMa systems. A possible correlation between LHα/Lbol and the Rossby number (the ratio between the rotational period and the convective time scale) is seen for those components showing emission.

Barden, S. C.

1985-08-01

150

Rs7206790 and rs11644943 in FTO Gene Are Associated with Risk of Obesity in Chinese School-Age Population  

PubMed Central

To evaluate the associations between candidate FTO single nucleotide polymorphisms (SNPs) and obesity, a case-control study was conducted among Chinese school-age children, which included 500 obese cases and 500 matched controls (age, gender and location). We selected 24 candidate FTO tag-SNPs via bio-informatics analysis and performed genotyping using SNPScan technology. Results indicated that rs7206790 and rs11644943 were significantly associated with obesity among school-age children in both additive and recessive models (P<0.05) after adjusting confounders. Comparing rs7206790 CC and CG genotype of carriers, those carrying the GG genotype had an increased risk of obesity (adjusted odds ratio [OR], 3.76; 95% Confidence interval [CI], 1.24–11.43). Carriers of the AA allele of rs11644943 had a lower risk of obesity (adjusted OR, 0.16; 95% CI, 0.04–0.72) compared with those of the T allele (TT and TA). These two SNPs (rs7206790 and rs11644943) were not Linkage Disequilibrium (LD) with previous reported obesity-associated SNPs. Under the recessive model adjusted for age and gender and location, rs7206790 GG allele carriers had significantly increased BMIs (P?=?0.012), weight (P?=?0.012), waist circumferences (WC) (P?=?0.045) and hip circumferences (HC) (P?=?0.033). Conversely, rs11644943 AA allele carriers had significantly decreased BMIs (P?=?0.006), WC (P?=?0.037) and Waist-to-height ratios (WHtR) (P?=?0.012). A dose-response relationship was found between the number of risk alleles in rs7206790, rs11644943 and rs9939609 and the risk of obesity. The Genetic Risk Score (GRS) of the reference group was 3; in comparison, those of 2, 4, and ?5 had ORs for obesity of 0.24 (95%CI, 0.05–1.13), 1.49 (95%CI, 1.10–2.01), and 5.20 (95%CI, 1.75–15.44), respectively. This study confirmed the role of FTO variation on genetic susceptibility to obesity. We reported two new obesity-related FTO SNPs (rs7206790 and rs11644943) among Chinese school-age children. PMID:25251416

Xu, Yuyang; Ling, Jie; Yang, Min; Wang, Hao; Zhang, Shuai; Zhang, Xuhui; Zhu, Yimin

2014-01-01

151

Radio emission from rapidly-rotating cool giant stars  

NASA Technical Reports Server (NTRS)

The results of a VLA program are reported to examine the radio continuum emission from 11 rapidly-rotating cool giant stars, all of which were originally believed to be single stars. Six of the 11 stars were detected as radio sources, including FK Com and HR 9024, for which there exist multifrequency observations. HD 199178, UZ Lib (now known to be a binary system), and HD 82558, for which there is only 6-cm data. The radio properties of these stars are compared with those of the active, rapidly rotating evolved stars found in the RS CVn binary systems.

Drake, Stephen A.; Walter, Frederick M.; Florkowski, David R.

1990-01-01

152

Inhibition of mini-TyrRS-induced angiogenesis response in endothelial cells by VE-cadherin-dependent mini-TrpRS.  

PubMed

To clarify whether a VE-cadherin-dependent pathway allows mini-TrpRS to inhibit mini-TrpRS-induced new blood vessel formation in endothelial cells (ECs), the inhibitory effects of mutant mini-TrpRS and VE-cadherin on mini-TrpRS-induced angiogenesis were investigated. The effects of mini-TyrRS and mini-TrpRS on EC proliferation were evaluated using an MTT colorimetric assay. Cell migration was assayed using a modified Boyden chamber technique. The angiogenic activity in vitro was evaluated by transwell migration assay and matrigel-induced capillary tube formation. It was found that mini-TrpRS does not inhibit the mini-TyrRS-induced proliferation and migration of EC under the condition of VE-cadherin knockout. While wild-type mini-TrpRS inhibited mini-TyrRS-induced angiogenesis, this activity vanished for the mutant protein. Also, the promotion of angiogenesis by mini-TyrRS and the inhibition of angiogenesis by mini-TrpRS were VEGFR2 dependent but not VEGF dependent. Mini-TyrRS was able to increase the protein expression of VEGFR-2 in the presence of VE-cadherin, while no stimulatory effect of mini-TyrRS was detected when VE-cadherin was not present. Angiogenesis is therefore stimulated by mini-TyrRS and inhibited by mini-TrpRS, raising the possibility that mini-TyrRS and mini-TrpRS stimulate a common downstream signaling event: VE-cadherin. Thus, naturally occurring fragments of the two proteins involved in translation, TyrRS and TrpRS, have opposing activities on angiogenesis. The opposing activities of the two tRNA synthetases suggest tight regulation of the balance between pro- and antiangiogenic stimuli. PMID:21442253

Zeng, Rui; Chen, Yu-cheng; Zeng, Zhi; Liu, Xiao-xia; Liu, Rui; Qiang, Ou; Li, Xian

2012-03-01

153

RS-34 Phoenix (Peacekeeper Post Boost Propulsion System) Utilization Study  

NASA Technical Reports Server (NTRS)

The Advanced Concepts Office (ACO) at the NASA Marshall Space Flight Center (MSFC) in conjunction with Pratt & Whitney Rocketdyne conducted a study to evaluate potential in-space applications for the Rocketdyne produced RS-34 propulsion system. The existing RS-34 propulsion system is a remaining asset from the de-commissioned United States Air Force Peacekeeper ICBM program, specifically the pressure-fed storable bipropellant Stage IV Post Boost Propulsion System, renamed Phoenix. MSFC gained experience with the RS-34 propulsion system on the successful Ares I-X flight test program flown in October 2009. RS-34 propulsion system components were harvested from stages supplied by the USAF and used on the Ares I-X Roll control system (RoCS). The heritage hardware proved extremely robust and reliable and sparked interest for further utilization on other potential in-space applications. MSFC is working closely with the USAF to obtain RS-34 stages for re-use opportunities. Prior to pursuit of securing the hardware, MSFC commissioned the Advanced Concepts Office to understand the capability and potential applications for the RS-34 Phoenix stage as it benefits NASA, DoD, and commercial industry. As originally designed, the RS-34 Phoenix provided in-space six-degrees-of freedom operational maneuvering to deploy multiple payloads at various orbital locations. The RS-34 Phoenix Utilization Study sought to understand how the unique capabilities of the RS-34 Phoenix and its application to six candidate missions: 1) small satellite delivery (SSD), 2) orbital debris removal (ODR), 3) ISS re-supply, 4) SLS kick stage, 5) manned GEO servicing precursor mission, and an Earth-Moon L-2 Waypoint mission. The small satellite delivery and orbital debris removal missions were found to closely mimic the heritage RS-34 mission. It is believed that this technology will enable a small, low-cost multiple satellite delivery to multiple orbital locations with a single boost. For both the small satellite delivery and the orbital debris mission candidates, the RS-34 Phoenix requires the least amount of modification to the existing hardware. The results of the RS-34 Phoenix Utilization Study show that the system is technically sufficient to successfully support all of the missions analyzed.

Esther, Elizabeth A.; Kos, Larry; Burnside, Christopher G.; Bruno, Cy

2013-01-01

154

RS-34 Phoenix (Peacekeeper Post Boost Propulsion System) Utilization Study  

NASA Technical Reports Server (NTRS)

The Advanced Concepts Office (ACO) at the NASA Marshall Space Flight Center (MSFC) in conjunction with Pratt & Whitney Rocketdyne conducted a study to evaluate potential in-space applications for the Rocketdyne produced RS-34 propulsion system. The existing RS-34 propulsion system is a remaining asset from the decommissioned United States Air Force Peacekeeper ICBM program; specifically the pressure-fed storable bipropellant Stage IV Post Boost Propulsion System, renamed Phoenix. MSFC gained experience with the RS-34 propulsion system on the successful Ares I-X flight test program flown in October 2009. RS-34 propulsion system components were harvested from stages supplied by the USAF and used on the Ares I-X Roll control system (RoCS). The heritage hardware proved extremely robust and reliable and sparked interest for further utilization on other potential in-space applications. Subsequently, MSFC is working closely with the USAF to obtain all the remaining RS-34 stages for re-use opportunities. Prior to pursuit of securing the hardware, MSFC commissioned the Advanced Concepts Office to understand the capability and potential applications for the RS-34 Phoenix stage as it benefits NASA, DoD, and commercial industry. Originally designed, the RS-34 Phoenix provided in-space six-degrees-of freedom operational maneuvering to deploy multiple payloads at various orbital locations. The RS-34 Phoenix Utilization Study sought to understand how the unique capabilities of the RS-34 Phoenix and its application to six candidate missions: 1) small satellite delivery (SSD), 2) orbital debris removal (ODR), 3) ISS re-supply, 4) SLS kick stage, 5) manned GEO servicing precursor mission, and an Earth-Moon L-2 Waypoint mission. The small satellite delivery and orbital debris removal missions were found to closely mimic the heritage RS-34 mission. It is believed that this technology will enable a small, low-cost multiple satellite delivery to multiple orbital locations with a single boost. For both the small satellite delivery and the orbital debris mission candidates, the RS-34 Phoenix requires the least amount of modification to the existing hardware. The results of the RS-34 Phoenix Utilization Study show that the system is technically sufficient to successfully support all of the missions analyzed

Esther, Elizabeth A.; Kos, Larry; Bruno, Cy

2012-01-01

155

Design and implementation of a fiber optic RS232 link  

NASA Astrophysics Data System (ADS)

This thesis investigates the feasibility of using a bi-directional fiber optic link to implement a RS232 data link. The results showed that a fiber optic link is a viable replacement. It offers a bandwidth up to 5 MHz, 250 times that of a RS232 data link. This fiber optic link was tested over a distance of 1.5 kilometers, nearly 100 times that of the present RS232 link. It also offers the benefits of space and weight savings and is comparable to devices produced commercially but at a substantial cost savings.

Ryan, James W.

1987-09-01

156

Enantioselective degradation of (2RS,3RS)-paclobutrazol in peach and mandarin under field conditions.  

PubMed

In this study we investigated the enantioselective degradation of (2RS,3RS)-paclobutrazol in peach and mandarin fruits under field conditions after foliar treatment at 500 mg active ingredient/L using a Lux Cellulose-1 chiral column on a reverse-phase liquid chromatography-tandem mass spectrometry system. Degradations of paclobutrazol in both fruits followed first-order kinetics, with half-lives of about 9 days. Initial deposits were 1.63 mg/kg on peach and 1.99 mg/kg on mandarin; terminal concentrations were lower than 0.05 mg/kg, which was acceptable in most cases. As anticipated, paclobutrazol levels in peels of mature mandarin were about 6.3 times higher than in pulp, indicating the potential risk of peel consumption. We also observed that paclobutrazol degradation in mature mandarin was relatively slow, indicating it might not be efficient enough to hold mandarin fruits on trees for lowering paclobutrazol concentrations. Significant enantioselectivity was observed: the (2R,3R)-enantiomer was preferentially degraded in mandarin (whole fruit, peels, and pulp) but enriched in peach. Because of its more rapid degradation in mandarin and the lower levels observed in pulp compared with peels, potential endocrine-related side effects due to the (2R,3R)-enantiomer pose less of a risk in mandarin than in peach. PMID:24890866

Wang, Xiangyun; Qi, Peipei; Yang, Guiling; Wang, Xinquan; Zhang, Hu; Xu, Hao; Wang, Zhiwei; Wang, Qiang

2014-08-01

157

Quantitative analysis of the association between CRP rs2808630 and rs1417938 polymorphisms and cancer risk  

PubMed Central

Accumulating evidence indicates that polymorphisms in the CRP gene are important in the development of cancer. The current meta-analysis was performed to investigate the association between CRP polymorphisms 3407 A>G (rs2808630) and 29 A>T (rs1417938), and the risk of developing cancer. A search of the relevant literature was conducted using the PubMed database to identify eligible studies published up until March 25, 2014. Five case-control studies involving 888 cases and 3,167 controls for the 3407 A>G polymorphism, and six case-control studies involving 3,110 cases and 5,951 controls for the 29 A>T polymorphism were included in the current meta-analysis. The pooled odds ratios with 95% confidence intervals were calculated using the fixed- or random-effects model. Meta-analysis identified no association between the CRP 3407 A>G and 29 A>T polymorphisms, and overall cancer risk. Additional stratified analysis by cancer type did not reveal any significant associations in the genetic models investigated. The findings of the present study indicated that CRP 3407 A>G and 29 A>T polymorphisms are not associated with cancer risk. PMID:25624919

WANG, JIAN-GONG; ZHANG, YANG; XIAO, TIAN-LIN

2015-01-01

158

10 CFR 434.103 - Referenced standards (RS).  

Code of Federal Regulations, 2010 CFR

...Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CODE FOR NEW FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH RISE RESIDENTIAL BUILDINGS Administration and Enforcement-General § 434.103 Referenced standards (RS). 103.1The...

2010-01-01

159

Naproxen–eudragit ® RS100 nanoparticles: Preparation and physicochemical characterization  

Microsoft Academic Search

The objective of the present study was to formulate naproxen–eudragit® RS100 nanoparticles and investigate the physicochemical characteristics of the prepared nanoparticles. The nanoparticles of naproxen with eudragit® RS100 were formulated using the solvent evaporation\\/extraction technique (the single emulsion technique). The effect of several process parameters, i.e., drug\\/polymer ratio, aqueous phase volume and speed of homogenization were considered on the size

Khosro Adibkia; Yousef Javadzadeh; Siavoush Dastmalchi; Ghobad Mohammadi; Fatemeh Kari Niri; Mahmood Alaei-Beirami

2011-01-01

160

Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn’s disease  

PubMed Central

AIM: To investigate the correlation between rs1568885, rs1813443 and rs4411591 polymorphisms and response to infliximab in a cohort of Greek patients with Crohn’s disease (CD). METHODS: One hundred and twenty-six patients diagnosed with CD based on standard clinical, endoscopic, radiological, and pathological criteria were enrolled in this study at the Gastroenterology Unit of the 2nd Department of Surgery and at the Colorectal Unit of the 1st Department of Propaedeutic Surgery. Infliximab at a dose of 5 mg/kg was administered intravenously at weeks 0, 2, 6 and then every 8 wk. Clinical and serological responses were assessed using the Harvey-Bradshaw Index and serum C-reactive protein (CRP) levels, respectively, and the endoscopic response was evaluated by ileocolonoscopy performed at baseline and after 12-20 wk of therapy. The changes in endoscopic appearance compared to baseline were classified into four categories, and patients were classified as responders and non-responders. Genomic DNA from whole peripheral blood was extracted and genotyping was performed by allele-specific polymerase chain reactions. ?2 test with Yate’s correction based on the S-Plus was used to compare the genotype frequencies. RESULTS: Eighty patients (63.49%) were classified as complete and 32 (25.39%) as partial responders to infliximab, while 14 (11.11%) were primary non-responders. No correlation was found between response to infliximab and patients’ characteristics such as age, gender and disease duration. There was consistency between Harvey-Bradshaw index scores and serum CRP levels. The TT genotype of the rs1568885 polymorphism was significantly related to partial response (P = 0.024) and resistance to infliximab (P = 0.007) while the AT genotype was more frequent in partial responders (P = 0.035) and in primary non-responders (P = 0.032). Regarding rs1813443, the CC genotype was found to be associated with partial response (P = 0.005) and primary resistance (P = 0.002) to infliximab while no association was found between the rs4411591 polymorphism and the clinical response to infliximab. CONCLUSION: Based on our results, the rs1568885 and rs1813443 polymorphisms are associated with clinical and biochemical response to infliximab in Greek patients with Crohn’s disease. PMID:24707144

Thomas, Diamantis; Gazouli, Maria; Karantanos, Theodoros; Rigoglou, Stella; Karamanolis, Georgios; Bramis, Konstantinos; Zografos, George; Theodoropoulos, George E

2014-01-01

161

Unified error model based spatial error compensation for four types of CNC machining center: Part II-unified model based spatial error compensation  

NASA Astrophysics Data System (ADS)

In this paper, a spatial error compensation method was proposed for CNC machining center based on the unified error model. The spatial error distribution was analyzed in this research. The result shows that the spatial error is relative to each axis of a CNC machine tool. Moreover, the spatial error distribution is non-linear and there is no regularity. In order to improve the modeling accuracy and efficiency, an automatic error modeling application was designed based on the orthogonal polynomials. To realize the spatial error compensation, a multi-thread parallel processing mode based error compensation controller was designed. Using the spatial error compensation method, the machine tools' accuracy is greatly improved compared to that with no compensation.

Fan, Kaiguo; Yang, Jianguo; Yang, Liyan

2014-12-01

162

40 CFR 180.1114 - Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS...  

Code of Federal Regulations, 2011 CFR

...syringae 742RS are exempted from the requirement of a tolerance in or on all raw agricultural commodities when applied as a frost protection agent or biological control agent to growing agricultural crops in accordance with good agricultural...

2011-07-01

163

40 CFR 180.1114 - Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS...  

Code of Federal Regulations, 2014 CFR

...syringae 742RS are exempted from the requirement of a tolerance in or on all raw agricultural commodities when applied as a frost protection agent or biological control agent to growing agricultural crops in accordance with good agricultural...

2014-07-01

164

40 CFR 180.1114 - Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS...  

Code of Federal Regulations, 2012 CFR

...syringae 742RS are exempted from the requirement of a tolerance in or on all raw agricultural commodities when applied as a frost protection agent or biological control agent to growing agricultural crops in accordance with good agricultural...

2012-07-01

165

40 CFR 180.1114 - Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS...  

Code of Federal Regulations, 2010 CFR

...syringae 742RS are exempted from the requirement of a tolerance in or on all raw agricultural commodities when applied as a frost protection agent or biological control agent to growing agricultural crops in accordance with good agricultural...

2010-07-01

166

40 CFR 180.1114 - Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS...  

Code of Federal Regulations, 2013 CFR

...syringae 742RS are exempted from the requirement of a tolerance in or on all raw agricultural commodities when applied as a frost protection agent or biological control agent to growing agricultural crops in accordance with good agricultural...

2013-07-01

167

A STUDY OF FAULT MONITORING IN CNC MACHINING OF FREE-FORM SURFACES BASED ON NN-WAVELET ANALYSIS–TECHNICAL COMMUNICATION  

Microsoft Academic Search

? Tool breakage and overcut are common fault patterns in the process of the free-form surface computer numerical control (CNC) machining. Starting from the analysis of the interactive relationship between the tool and the free-form surface, the geometrical model of the overcut fault is set up in this paper. By using superior time-frequency localization feature of the wavelet transformation and

Shuxin Xu; Yiqiang Wang; Ji Zhao; Guan Le

2008-01-01

168

Inhibition of mini-TyrRS-induced angiogenesis response in endothelial cells by VE-cadherin-dependent mini-TrpRS  

Microsoft Academic Search

To clarify whether a VE-cadherin-dependent pathway allows mini-TrpRS to inhibit mini-TrpRS-induced new blood vessel formation\\u000a in endothelial cells (ECs), the inhibitory effects of mutant mini-TrpRS and VE-cadherin on mini-TrpRS-induced angiogenesis\\u000a were investigated. The effects of mini-TyrRS and mini-TrpRS on EC proliferation were evaluated using an MTT colorimetric assay.\\u000a Cell migration was assayed using a modified Boyden chamber technique. The angiogenic

Rui ZengYu-cheng; Yu-cheng Chen; Zhi Zeng; Xiao-xia Liu; Rui Liu; Ou Qiang; Xian Li

169

Luminescent organoplatinum(II) complexes with functionalized cyclometalated C^N^C ligands: structures, photophysical properties, and material applications.  

PubMed

A series of [(R'-C^N^C-R'')Pt(L)] complexes with doubly deprotonated cyclometalated R'-C^N^C-R'' ligands (R'-C^N^C-R''=2,6-diphenylpyridine derivatives) functionalized with carbazole, fluorene, or thiophene unit(s) have been synthesized and their photophysical properties studied. The X-ray crystal structures reveal extensive intermolecular ?···? and C-H···? interactions between the cyclometalated C^N^C ligands. Compared to previously reported cyclometalated platinum(II) complexes [(C^N^C)Pt(L)], which are non-emissive in solution at room temperature, the carbazole-, fluorene- and thiophene-functionalized [(R'-C^N^C-R'')Pt(L)] (L=DMSO 1-9, C?N-Ar, 1a-9a) complexes are emissive in solution at room temperature with ?(max) at 564-619 nm and ?=0.02-0.26. The emissions of the [(R'-C^N^C-R'')Pt(L)] complexes are attributed to electronic excited states with mixed (3)MLCT and (3)IL character. The carbazole/fluorene/thiophene unit(s) allow the tuning of the electronic properties of the [(R'-C^N^C-R'')Pt] moiety, with the emission maxima in a range of 564-619 nm. These are the first examples of organoplatinum(II) complexes bearing doubly deprotonated cyclometalated C^N^C ligands that are emissive in solution at room temperature. In non-degassed DMSO, the emission intensities of 6a-9a are enhanced upon exposure to ambient light. This phenomenon is caused by reacting photogenerated (1)O(2) with a DMSO molecule to form dimethyl sulfone, leading to the removal of dissolved oxygen in solution. Self-assembled nanowires and nanorods are obtained from precipitation of 3a in THF/H(2)O and 8a in DMSO/Et(2)O, respectively. The [(R'-C^N^C-R'')Pt(L)] complexes are soluble in common organic solvents with a high thermal stability (>300 °C), rendering them as phosphorescent dopants for organic light-emitting diode (OLEDs) applications. Red OLEDs with CIE coordinates of (0.65±0.01, 0.35±0.01) were fabricated from 7a or 8a. A maximum external efficiency (?(Ext)) of 12.6% was obtained for the device using 8a as emitter. PMID:22170325

Kui, Steven C F; Hung, Faan-Fung; Lai, Shiu-Lun; Yuen, Mai-Yan; Kwok, Chi-Chung; Low, Kam-Hung; Chui, Stephen Sin-Yin; Che, Chi-Ming

2012-01-01

170

OPMILL - MICRO COMPUTER PROGRAMMING ENVIRONMENT FOR CNC MILLING MACHINES THREE AXIS EQUATION PLOTTING CAPABILITIES  

NASA Technical Reports Server (NTRS)

OPMILL is a computer operating system for a Kearney and Trecker milling machine that provides a fast and easy way to program machine part manufacture with an IBM compatible PC. The program gives the machinist an "equation plotter" feature which plots any set of equations that define axis moves (up to three axes simultaneously) and converts those equations to a machine milling program that will move a cutter along a defined path. Other supported functions include: drill with peck, bolt circle, tap, mill arc, quarter circle, circle, circle 2 pass, frame, frame 2 pass, rotary frame, pocket, loop and repeat, and copy blocks. The system includes a tool manager that can handle up to 25 tools and automatically adjusts tool length for each tool. It will display all tool information and stop the milling machine at the appropriate time. Information for the program is entered via a series of menus and compiled to the Kearney and Trecker format. The program can then be loaded into the milling machine, the tool path graphically displayed, and tool change information or the program in Kearney and Trecker format viewed. The program has a complete file handling utility that allows the user to load the program into memory from the hard disk, save the program to the disk with comments, view directories, merge a program on the disk with one in memory, save a portion of a program in memory, and change directories. OPMILL was developed on an IBM PS/2 running DOS 3.3 with 1 MB of RAM. OPMILL was written for an IBM PC or compatible 8088 or 80286 machine connected via an RS-232 port to a Kearney and Trecker Data Mill 700/C Control milling machine. It requires a "D:" drive (fixed-disk or virtual), a browse or text display utility, and an EGA or better display. Users wishing to modify and recompile the source code will also need Turbo BASIC, Turbo C, and Crescent Software's QuickPak for Turbo BASIC. IBM PC and IBM PS/2 are registered trademarks of International Business Machines. Turbo BASIC and Turbo C are trademarks of Borland International.

Ray, R. B.

1994-01-01

171

Expression, purification, and characterization of rhTyrRS  

PubMed Central

Background Aminoacyl-tRNA synthetases (AARSs) catalyze the first step of protein synthesis. Emerging evidence indicates that AARSs may have additional functions, playing a role in signal transduction pathways regulating thrombopoiesis and inflammation. Recombinant human tyrosyl-tRNA synthetase (rhTyrRS) is engineered with a single amino acid substitution that unmasks its cytokine activity. An industrial production method that provides high yield as well as high purity, quality, and potency of this protein is required for preclinical research. Results We expressed codon-optimized rhTyrRS in Escherichia coli under fermentation conditions. Soluble protein was purified by a three-step purification method using cation exchange chromatography, gel filtration chromatography, and anion exchange chromatography. We also established a method to test the biological activity of rhTyrRS by measuring aminoacylation and IL-8 release in rhTyrRS-treated HL-60 cells. Conclusions The characterization of purified rhTyrRS indicated that this protein can be used in pharmacodynamic and pharmacokinetic studies. PMID:25027604

2014-01-01

172

3D simulations of RS Ophiuchi: from accretion to nova blast  

NASA Astrophysics Data System (ADS)

Context: The binary star system RS Ophiuchi is a recurrent nova, with outbursts occurring about every 22 years. It consists of a red giant star (RG) and a wind accreting white dwarf close to the Chandrasekhar limit. This system is considered a prime candidate for evolving into an SNIa. For its most recent outbursts in 1985 and 2006, exquisite multiwavelength observational data are available. Aims: Deeper physical insight is needed regarding the inter-outburst accretion phase and the dynamical effects of the subsequent nova explosion in order to improve the interpretation of the observed data and to shed light on whether the system is an SNIa progenitor. Methods: We present a 3D hydrodynamic simulation of the quiescent accretion with the subsequent explosive phase. Results: The computed circumstellar mass distribution in the quiescent phase is highly structured with a mass enhancement in the orbital plane of about a factor of 2 as compared to the poleward directions. The simulated nova remnant evolves aspherically, propagating faster toward the poles. The shock velocities derived from the simulations agree with those derived from observations. For v_RG = 20 km s-1 and for nearly isothermal flows, we find that 10% of the mass lost by the RG is transfered to the WD. For an RG mass loss of 10-7~M? yr-1, the orbit of the system decays by 3% per million years. With the derived mass transfer rate, multi-cycle nova models provide a qualitatively correct recurrence time, amplitude, and fastness of the nova. Conclusions: Our 3D hydrodynamic simulations provide, along with the observations and nova models, the third ingredient for a deeper understanding of the recurrent novae of the RS Oph type. In combination with recent multi-cycle nova models, our results suggest that the WD in RS Oph will increase in mass. Several speculative outcomes then seem plausible. The WD may reach the Chandrasekhar limit and explode as an SN Ia. Alternatively, the mass loss of the RG could result in a smaller Roch volume, a common envelope phase, and a narrow WD + WD system. Angular momentum loss due to gravitational wave emission could trigger the merger of the two WDs and - perhaps - an SN Ia via the double degenerate scenario. In the frame of the computing project “Cosmic Engines in Galaxies”. The movie is only available in electronic form at http://www.aanda.org

Walder, R.; Folini, D.; Shore, S. N.

2008-06-01

173

Association of Versican (VCAN) gene polymorphisms rs251124 and rs2287926 (G428D), with intracranial aneurysm  

PubMed Central

Intracranial aneurysm (IA) accounts for 85% of Subarachnoid Hemorrhage (SAH) and is mainly caused due to the weakening of arterial wall. The structural integrity of the intracranial arteries is mainly influenced by the extracellular matrix (ECM) remodeling. The Proteoglycan Versican plays an important role in extracellular matrix assembly and plays a major role in the pathogenesis of IA. The linkage studies also indicated VCAN as a putative candidate gene for IA in the 5q22–31 region. Using a case–control study design, we tested the hypothesis whether the variants in VCAN gene, nonsynonymous variants in the coding region of Glycosaminoglycan ? (GAG-?) and GAG-? and two reported SNPs involved in splicing rs251124 and rs173686 can increase the risk of aSAH among South Indian patients, either independently, or by interacting with other risk factors of the disease. We selected 200 radiologically confirmed aneurysmal cases and 250 ethnically, age and sex matched controls from the Dravidian Malayalam speaking population of South India. The present study reiterated the earlier association of rs251124 with intracranial aneurysm (P = 0.0002) and also found a novel association with rs2287926 (G428D) in exon 7 coding for GAG-? with intracranial aneurysm (P = 0.0015). Interestingly, both these SNPs contributed to higher risk for aneurysm in males. In-silico analysis predicted this SNP to have the highest functional relevance in the gene which might have a potentially altered regulatory role in transcription and splicing. Using meta-analysis with available literature rs251124 was found to be the strongest intracranial aneurysm marker for global ethnicities. This study with a novel functional SNP rs2287926 (G428D) further substantiates the potential role of VCAN in the pathogenesis of IA. PMID:25606449

Sathyan, Sanish; Koshy, Linda V.; Balan, Shabeesh; Easwer, H.V.; Premkumar, S.; Nair, Suresh; Bhattacharya, R.N.; Alapatt, Jacob P.; Banerjee, Moinak

2014-01-01

174

An extended d(min) = 4 RS code  

NASA Technical Reports Server (NTRS)

A minimum distance d sub m - 4 extended Reed - Solomon (RS) code over GF (2 to the b power) was constructed. This code is used to correct any single byte error and simultaneously detect any double byte error. Features of the code; including fast encoding and decoding, are presented.

Deng, H.; Costello, D. J., Jr.

1983-01-01

175

Restoring New Agegraphic Dark Energy in RS II Braneworld  

E-print Network

Motivated by recent works [1,2], we investigate new agegraphic model of dark energy in the framework of RS II braneworld. We also include the case of variable gravitational constant in our model. Furthermore, we establish correspondence between the new agegraphic dark energy with other dark energy candidates based on scalar fields.

Mubasher Jamil; Kayoomars Karami; Ahmad Sheykhi

2011-06-14

176

Analysis of china grassland dynamic based on RS and GIS  

Microsoft Academic Search

We monitor dynamic of china grassland from 1995 to 2000 by using TM datum based RS and GIS technology. The datum are extracted from LANDSAT TM image. The task of image classification is mainly taken on by experts with the help of relief map, navigation photo etc, thus grassland coverage could be acquired. With the high and middle cover grassland

Zou Ya-rong; Zhang Zeng-xiang; Zhou Quan-bin; Tan Wen-bin

2003-01-01

177

ARIES-RS maintenance approach for high availability  

Microsoft Academic Search

The ARIES-RS tokamak power plant study developed a design approach which has the potential for high availability. One of the keys for high plant availability is a design that allows rapid replacement of the power core sectors. This is achieved by using large maintenance ports for each power core sector, enabling the removal of entire sectors composed of inboard and

S. Malang; F. Najmabadi; L. M. Waganer; M. S. Tillack

1998-01-01

178

MaRS: Mars Express Orbiter Radio Science  

Microsoft Academic Search

The Mars Express Orbiter Radio Science (MaRS) experiment will employ radio occultation to (I) sound the neutral martian atmosphere to derive vertical density, pressure and temperature profiles as functions of height to resolutions better than 100 m, (II) sound the ionosphere to derive vertical ionospheric electron density profiles and a description of the ionosphere through its diurnal and seasonal variations

M. Pätzold; F. M. Neubauer; L. Carone; A. Hagermann; C. Stanzel; B. Häusler; S. Remus; J. Selle; D. Hagl; D. P. Hinson; R. A. Simpson; G. L. Tyler; S. W. Asmar; W. I. Axford; T. Hagfors; J.-P. Barriot; J.-C. Cerisier; T. Imamura; K.-I. Oyama; P. Janle; G. Kirchengast; V. Dehant

2004-01-01

179

THE INVENTION OF TRUTH UHC RS 101 A1  

E-print Network

THE INVENTION OF TRUTH UHC RS 101 A1 Professor Alicia Borinsky Syllabus Spring 2011 The seminar addresses contemporary strategies for representing truth in literature and film through the examination for the representation and embodiment of truth? What are the contemporary cultural realms claiming a privileged

Guenther, Frank

180

An Edge Weighted RS image Quality Evaluation Method  

Microsoft Academic Search

The approaches for remote sensing (RS) image quality evaluation can be categorized by two different criteria. One is the subjective image quality testing based on many observers. The other is the objective image quality testing based on mathematical calculation. Compared with the subjective method, objective image quality testing is easier for implementation. However, the traditional objective image quality evaluation models,

Qin Lu; Liebo Du; Xuemin Xiao

2008-01-01

181

Spectroscopy of Nine Cataclysmic Variable Stars  

NASA Astrophysics Data System (ADS)

We present optical spectroscopy of nine cataclysmic binary stars, mostly dwarf novae, obtained primarily to determine orbital periods Porb. The stars and their periods are LX And, 0.1509743(5) days; CZ Aql, 0.2005(6) days; LU Cam, 0.1499686(4) days; GZ Cnc, 0.0881(4) days; V632 Cyg, 0.06377(8) days; V1006 Cyg, 0.09903(9) days; BF Eri, 0.2708804(4) days; BI Ori, 0.1915(5) days; and FO Per, for which Porb is either 0.1467(4) or 0.1719(5) days. Several of the stars proved to be especially interesting. In BF Eri, we detect the absorption spectrum of a secondary star of spectral type K3 +/- 1 subclass, which leads to a distance estimate of ~1 kpc. However, BF Eri has a large proper motion (~100 mas yr-1), and we have a preliminary parallax measurement that confirms the large proper motion and yields only an upper limit for the parallax. BF Eri's space velocity is evidently large, and it appears to belong to the halo population. In CZ Aql, the emission lines have strong wings that move with large velocity amplitude, suggesting a magnetically channeled accretion flow. The orbital period of V1006 Cyg places it squarely within the 2 to 3 hr ``gap'' in the distribution of cataclysmic binary orbital periods. Based on observations obtained at the MDM Observatory, operated by Dartmouth College, Columbia University, Ohio State University, Ohio University, and the University of Michigan.

Sheets, Holly A.; Thorstensen, John R.; Peters, Christopher J.; Kapusta, Ann B.; Taylor, Cynthia J.

2007-05-01

182

Modulation of central noradrenergic function by RS-15385-197.  

PubMed Central

1. RS-15385-197, a highly potent and selective alpha 2-adrenoceptor antagonist, was examined in a variety of in vitro and in vivo functional tests to assess the selectivity of its interaction with central noradrenergic neurones in the rat. 2. In hypothalamic slices, RS-15385-197 was potent in augmenting K(+)-evoked release of [3H]-noradrenaline, with an EC50 of 9 nM. Idazoxan and yohimbine showed 100 fold less activity. This was due to its antagonist action at presynaptic alpha 2-adrenoceptors, as RS-15385-197 (10 microM), did not directly release [3H]-noradrenaline from cortical slices unlike reserpine (10 microM), and did not inhibit noradrenaline re-uptake into cortical synaptosomes. 3. In vivo, RS-15385-197 (0.5 mg kg-1, p.o.) increased levels of 3-methoxy-4-hydroxy-phenylglycol (MHPG) in the cerebral cortex without modifying levels of 5-hydroxyindoleacetic acid (5-HIAA). This dose, but not a lower dose (0.1 mg kg-1, p.o.) caused beta-adrenoceptor down-regulation in the cortex when administered once daily for 14 days whereas 5-HT2 receptor number was unaltered, indicating a selective effect on noradrenergic transmission. 4. Selective depletion of cortical 5-HT by administration of p-chlorophenylalanine (PCPA; 100 mg kg-1, i.p. for 14 days) or 5,7-dihydroxytryptamine (5,7-DHT; 150 micrograms i.c.v.) prevented the beta-adrenoceptor down-regulation caused by RS-15385-197, indicating that a tonic 5-hydroxytryptaminergic input was required for it to elicit beta-adrenoceptor down-regulation.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8095421

Redfern, W. S.; MacKinnon, A. C.; Brown, C. M.; Martin, A. B.; Kilpatrick, A. T.; Clague, R. U.; Spedding, M.

1993-01-01

183

Fixed-Phase Observations of RS Canum Venaticorum and BY Draconis Systems  

NASA Astrophysics Data System (ADS)

We present our data set of same-hemisphere, or fixed-phase, observations of five RS Canum Venaticorum and BY Draconis binaries made with the Solar-Stellar Spectrograph at Lowell Observatory. The purpose of this study is to evaluate the level of intrinsic variability in the components of these systems, and to compare it with variability arising from rotational modulation and from long-term, activity cycle-related variability. We obtain fixed-phase observations by observing tidally locked binaries with near-integral-day periods. The fixed-phase observations reveal that the intrinsic variability of the stellar hemispheres is significantly less than the variability induced by rotational modulation or by long-term, activity-cyclic evolution, but only when several spectral features are considered in tandem. Fixed-phase ``flickering'' of the stellar hemispheres is often apparent at a higher level than the rotational or long-term modulation in individual activity indicators. Interpretation of rotational or long-term modulation in active, late-type stars using data that do not allow quantification of the fixed-phase variability of the stars (i.e., data that do not span several rotational periods) is extremely risky.

Hall, Jeffrey C.; Wolovitz, Jeffrey B.

1998-06-01

184

A catalog of chromospherically active binary stars  

NASA Astrophysics Data System (ADS)

The authors have compiled a catalog of 168 chromospherically active binary stars including the class of RS Canum Venaticorum binaries, BY Draconis binaries and other binaries which show "strong" Ca II H and K emission in their spectra. The catalog contains information on the photometric, spectroscopic, orbital and physical properties of the systems as well as the space motions and positions. Summarized in a candidate list are an additional 37 stars having similar characteristics but which are not definitely known binaries or have not had H and K emission observed. A bibliography and notes for each star are included to direct interested workers to primary references for each of the systems. The catalog contains stars in both the northern and the southern sky.

Strassmeier, K. G.; Hall, D. S.; Zeilik, M.; Nelson, E.; Eker, Z.; Fekel, F. C.

1988-02-01

185

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins.  

PubMed Central

The chicken beta-globin enhancer is critical for the tissue- and developmental stage-specific expression of the beta-globin genes. This enhancer contains two indispensable cis elements, one containing two GATA sites and the other containing an NF-E2 site. To identify the putative transcription factor acting through the NF-E2 motif in the chicken beta-globin enhancer, we screened chicken cDNA libraries with a mouse p45 NF-E2 cDNA probe and isolated cDNA clones which encode a protein of 582 amino acid residues. This protein contains a region that includes the basic region-leucine zipper domain which is well conserved among members of the CNC family proteins (Cap 'n' collar, p45 NF-E2, LCR-F1, Nrf1, and Nrf2). Hence, we named this protein ECH (erythroid cell-derived protein with CNC homology). ECH is expressed abundantly in cultured erythroid cells undergoing terminal differentiation, peripheral erythrocytes, and some nonhematopoietic tissues. Since most of the cDNA clones obtained from the chicken erythrocyte cDNA library encoded ECH, ECH is likely the predominant CNC family protein present in avian peripheral erythrocytes. Like p45 NF-E2, ECH can heterodimerize with any of the small Maf family proteins and bind the NF-E2 site as a heterodimer in vitro. In a transfection assay, ECH transactivates transcription depending on the presence of NF-E2 sites on the reporter gene plasmid. These results indicate that ECH is likely a key regulator of avian erythropoiesis. PMID:7623813

Itoh, K; Igarashi, K; Hayashi, N; Nishizawa, M; Yamamoto, M

1995-01-01

186

Period04 FCAPT uvby Photometric Studies of Eight Magnetic CP Stars  

NASA Astrophysics Data System (ADS)

We present Four College Automated Photometric Telescope (FCAPT) differential Stromgren uvby photometry of 8 magnetic CP (mCP) stars: HD 5797 (V551 Cas), HD 26792 (DH Cam), HD 27309 (56 Tau, V724 Tau), HD 49713 (V740 Mon), HD 74521 (49 Cnc, BI Cnc), HD 120198 (84 UMa, CR UMa), HD 171263 (QU Ser), and HD 215441 (GL Lac, Babcock's star). Our data sets are larger than those of most mCP stars in the literature. These are the first FCAPT observations of HD 5797, HD 26792, HD 49713, and HD 171263. Those for the remaining four stars substantially extend published FCAPT data. The FCAPT observed some stars for a longer time range and with greater accuracy than other optical region automated photometric telescopes.Our goals were to determine very accurate periods, the u, v, b, and y amplitudes, and if there were any long period periods. In addition we wanted to compare our results with those of magnetic field measurements to help interpret the light curves.We used the Period04 computer program to analyze the light curves. This program provides errors for the derived quantities as it fits the light curve. Our derived periods of 68.046 +/- 0.008 days for HD 5797, 3.80205 +/- 0.00006 days for HD 26792, 1.56889 +/- 0.000002 days for HD 27309, 2.13536 +/- 0.00002 days for HD 49713, 7.0505 +/- 0.0001 days for HD 74521, 1.38577 +/- 0.000004 days for HD 120198, 3.9974 +/- 0.0001days for HD 171263, and 9.487792 +/- 0.00005 days for HD 215441 are refinements of the best determinations in the literature.

Adelman, Saul J.; Dukes, Robert J.

2014-06-01

187

Far-infrared data for symbiotic stars. I - The IRAS pointed observations  

Microsoft Academic Search

The authors present IRAS pointed observations of eight symbiotic stars. Five S-type symbiotics (EG And, T CrB, RS Oph, AR Pav, and AX Per) have IR energy distributions that are very similar to those of normal M giants. Free-free emission may supply a fraction of the observed 12 and 25 mum flux in RS Oph, AR Pav, and AX Per.

Scott J. Kenyon; Telmo Fernandez-Castro; Robert E. Stencel

1986-01-01

188

Photometric and Ca II H and K Spectroscopic Variations in Nearby Sun-like Stars with Planets. III.  

NASA Astrophysics Data System (ADS)

We present the results of an analysis of time-series photometry, Ca II H and K spectrophotometry, and high-dispersion visible spectra of nine nearby Sun-like stars recently identified as having planets. For the six stars whose presumed planets have orbital periods of less than 4 months (? Boo, 51 Peg, ? And, ?1 Cnc, ? CrB, and 70 Vir), sine-curve fits to the photometric data show no variations with semiamplitude greater than 1 or 2 parts in 104. Photometric variations in 47 UMa are similarly small, although our photometric data of this star are slightly affected by variability of the comparison star. Nonvariability at this level of precision is sufficient to rule out surface magnetic activity as the cause of the observed radial-velocity variations in these seven stars and makes nonradial pulsations unlikely as well. Thus, our photometry provides indirect but strong support for true reflex motions-planets-in these seven stars, but cannot yet so support the planetary hypothesis for the two additional stars, 16 Cyg B and Gl 411. Continued photometric monitoring of the short-period systems may soon result in the direct detection of these planets in reflected light. We have used our photometric fluxes to search for possible transits of the extrasolar planets. Transits definitely do not occur in ? Boo, 51 Peg, ? And, and ?1 Cnc, and probably do not occur in ? CrB and 70 Vir. Our transit-search results are inconclusive for 47 UMa, and we cannot address the issue for 16 Cyg B and Gl 411. The precision of our photometry is sufficient to detect transits of planets even if they are not gas giants, as currently assumed, but much smaller objects with rocky compositions. The chance of finding at least one transit in the six stars is ~40%. We find significant year-to-year photometric variability only in ? Boo, which is not only the youngest star in the sample but also the star with the shallowest convective zone. The interseasonal range in its yearly mean photometric flux is ~0.002 mag, roughly twice the 0.0008 mag decadal variation in the Sun's total irradiance. Monitoring of the relative Ca II H and K fluxes began between 1966 and 1968 for 51 Peg, ? Boo, ? CrB, and Gl 411, between 1990 and 1993 for 47 UMa, 70 Vir, 16 Cyg B, and ?1 Cnc, and in 1996 for ? And. The data have been newly recalibrated for improved long-term instrumental stability, resulting in better precision of the Ca II records. Five of the nine stars in this study have little or no detectable year-to-year variation in Ca II flux. The remaining four show moderate or pronounced variability: ? Boo, whose radial-velocity and photometric variations have comparatively high amplitudes; Gl 411, whose planetary companion was inferred astrometrically, not spectroscopically; ?1 Cnc, which may undergo decadal cyclic activity; and ? And, which shows moderate year-to-year variability. Except for 47 UMa, intraseasonal variability consistent with rotation was detected in the Ca II records of all stars. However, the rotation periods determined for ? And, 70 Vir, and 16 Cyg B are of low confidence. An examination of the recalibrated Ca II records for 51 Peg finds a rotation period of 22 days, in contrast to our previous result of 37 days. Ages have been estimated from the mean Ca II flux and, where possible, the rotation period. We find general consistency with the ages determined by others comparing properties determined from high-resolution spectroscopy to evolutionary models, although the uncertainties are, in general, large. Based on observations made at Mount Wilson Observatory, operated by the Mount Wilson Institute, under an agreement with the Carnegie Institution of Washington and the automatic photoelectric telescope at Fairborn Observatory in the Patagonia Mountains of southern Arizona.

Henry, Gregory W.; Baliunas, Sallie L.; Donahue, Robert A.; Fekel, Francis C.; Soon, Willie

2000-03-01

189

RS485 serial port pseudo-full-duplex communication research and application  

Microsoft Academic Search

The RS-485 serial port communication is very popular in a monitoring and controlling system. A concept of RS-485 free port pseudo-full-duplex communication is presented in this paper, that is, RS-485 can not only send timed messages continuously but also receive messages at any moment from the host computer. Since RS-485 serial port has the advantage of far distance communication and

Su Xunwen; Wang Shaoping; Zhu Dongmei; Qishen Zhu

2010-01-01

190

Radiation Dry Bias of the Vaisala RS92 Humidity Sensor  

NASA Technical Reports Server (NTRS)

The comparison of simultaneous humidity measurements by the Vaisala RS92 radiosonde and by the Cryogenic Frostpoint Hygrometer (CFH) launched at Alajuela, Cosla Rica, during July 2005 reveals a large solar radiation dry bias of the Vaisala RS92 humidity sensor and a minor temperature-dependent calibration error. For soundings launched at solar zenith angles between 10" and 30 , the average dry bias is on the order of 9% at the surface and increases to 50% at 15 km. A simple pressure- and temperature-dependent correction based on the comparison with the CFH can reduce this error to less than 7% at all altitudes up to 15.2 km, which is 700 m below the tropical tropopause. The correction does not depend on relative humidity, but is able to reproduce the relative humidity distribution observed by the CFH.

Vomel, H.; Selkirk, H.; Miloshevich, L.; Valverde-Canossa, J.; Valdes, J.; Kyro, E.; Kivi, R.; Stolz, W.; Peng, G.; Diaz, J. A.

2007-01-01

191

Coordinated ultraviolet and radio observations of selected nearby stars  

NASA Technical Reports Server (NTRS)

All of the US2 shifts assigned were successfully completed with simultaneous International Ultraviolet Explorer (IUE) and the Very Large Array (VLA) observations of the proposed target stars. The target stars included dwarf M flare stars and RS CVn stars. The combined ultraviolet (IUE) and microwave (VLA) observations have provided important new insights to the radiation mechanisms at these two widely-separated regions of the electromagnetic spectrum. The VLA results included the discovery of narrow-band microwave radiation and rapid time variations in the microwave radiation of dwarf M flare stars. The results indicate that conventional radiation mechanisms cannot explain the microwave emission from these stars. In general, ultraviolet variations and bursts occur when no similar variations are detected at microwave wavelengths and vice versa. Although these is some overlap, the variations in these two spectral regions are usually uncorrelated, suggesting that there is little interaction between the activity centers at the two associated atmospheric levels.

Lang, Kenneth R.

1987-01-01

192

Network sensor of temperature & humidity based on RS485 interface  

Microsoft Academic Search

RS485 is an important communication protocol during CPU and external communication device, which is widely used in monitor-control system and project application. DS18B20 is used to test temperature in the sensor of temperature and humidity based on 89S52 MCU. ADC0831 is extended to convert the output signal of humidity sensor-NKHT, from which humidity value can be got. The value of

Lv Zhigang; Wang Peng

2010-01-01

193

The Nebulosity and Distance of the Cepheid RS Puppis  

E-print Network

Adopting a distance for RS Pup derived from a period-luminosity relation based on Cepheid parallaxes, it is shown that the phase-lag observations of the surrounding nebulosity by Kervella et al. are well fitted by a model of an equatorial disc at an angle of 8.1 $\\pm$ 0.6 degrees to the plane of the sky. The astrophysical implications of this are briefly mentioned.

Michael W. Feast

2008-04-01

194

Higher Curvature Effects in the ADD and RS Models  

SciTech Connect

Over the last few years several extra-dimensional models have been introduced in attempt to deal with the hierarchy problem. These models can lead to rather unique and spectacular signatures at Terascale colliders such as the LHC and ILC. The ADD and RS models, though quite distinct, have many common feature including a constant curvature bulk, localized Standard Model(SM) fields and the assumption of the validity of the EH action as a description of gravitational interactions.

Rizzo, Thomas G.; /SLAC

2006-07-05

195

Alkaline protease from Thermoactinomyces sp. RS1 mitigates industrial pollution.  

PubMed

Proteases have found a wide application in the several industrial processes, such as laundry detergents, protein recovery or solubilization, prion degradation, meat tenderizations, and in bating of hides and skins in leather industries. But the main hurdle in industrial application of proteases is their economical production on a large scale. The present investigation aimed to exploit the locally available inexpensive agricultural and household wastes for alkaline protease production using Thermoactinomyces sp. RS1 via solid-state fermentation (SSF) technique. The alkaline enzyme is potentially useful as an additive in commercial detergents to mitigate pollution load due to extensive use of caustic soda-based detergents. Thermoactinomyces sp. RS1 showed good protease production under SSF conditions of 55 °C, pH 9, and 50 % moisture content with potato peels as solid substrate. The presented findings revealed that crude alkaline protease produced by Thermoactinomyces sp. RS1 via SSF is of potential application in silver recovery from used X-ray films. PMID:24122212

Verma, Amit; Ansari, Mohammad W; Anwar, Mohmmad S; Agrawal, Ruchi; Agrawal, Sanjeev

2014-05-01

196

Different angiogenesis effect of mini-TyrRS/mini-TrpRS by systemic administration of modified siRNAs in rats with acute myocardial infarction.  

PubMed

We aimed to clarify the different angiogenesis effects of mini-tyrosyl-tRNA synthetase (TyrRS)/minitryptophanyl-tRNA synthetase (TrpRS) in rodent primates with acute myocardial infarction, by delivering small interfering RNAs (siRNAs) systemically in a liposomal formulation. Left coronary artery ligation was used to establish the model of acute myocardial infarction in rats; mini-TyrRS/mini-TrpRS-specific siRNAs were encapsulated in stable nucleic acid lipid particles (SNALP), and administered by intravenous injection to rats. Rats were divided into four experiment groups: sham operated group (no left anterior descending artery [LAD] occlusion); negative control group (LAD occlusion + saline injection); mock transfection group (LAD occlusion + mock transfected injection); experiment group (LAD occlusion + mini-TyrRS/mini-TrpRS-specific siRNAs injection). Silencing efficiency was assayed by Western blotting. To determine whether mini-TyrRS/mini-TrpRS affected the angiogenesis activity of rats with myocardial infarction, we measured the myocardial infarction size by TTC staining, and the capillary density using immunohistochemistry staining, to investigate the expression of factor VIII. The myocardial infarction size and the capillary density of mini-TyrRS-siRNA group were respectively 18.89% and 8.64/0.1 mm(2) 1 month after ligation, while in the mini-TrpRS-siRNA group these values were 7.33% and 17.32/0.1 mm(2), significantly different compared with the mock transfection group (14.19%; 13.56/0.1 mm(2)) and negative control group (14.28%; 13.89/0.1 mm(2)), P < 0.05. There were no significant changes between the mock transfection group and the negative control group, P > 0.05. These results indicated that angiogenesis is either stimulated by mini-TyrRS or inhibited by mini-TrpRS in rat models with acute myocardial infarction. PMID:20676842

Zeng, Rui; Chen, Yu-Cheng; Zeng, Zhi; Liu, Wei-Qiang; Liu, Xiao-Xia; Liu, Rui; Qiang, Ou; Li, Xian

2010-07-01

197

Flux density and polarization observations of HIPPARCOS radio stars  

NASA Astrophysics Data System (ADS)

Simultaneous flux density measurements with the 64 m antenna of the Madrid Deep Space Communication Complex (DSCC) at a wavelength of 13.1 cm and 3.6 cm, or of right and left circular polarization at 3.6 cm of a group of radio stars from the Hipparcos Input Catalogue, are reported. The total number of stars observed is 33, while the number of stars detected is 9. The polarization measurements of RS CVn systems are in agreement with a gyrosynchrotron emission mechanism. The observations of LS I +61°303 confirm the period emission at 8.4 GHz.

Paredes, J. M.; Estalella, R.; Rius, A.

1987-11-01

198

Stationary Star  

NSDL National Science Digital Library

This is an activity about star movement due to the Earth's rotation. Learners will utilize the Sky Tonight online program to find the star that appears stationary in our night sky. They will then draw conclusions about the Earthâs rotation based on the position changes of certain stars. This activity requires the use of a computer with Internet access. This activity is Sky Tonight Activity 2 in a larger resource, Space Update.

199

Sea Stars  

NSDL National Science Digital Library

At first glance, starfish, more properly called sea stars, aren’t doing much of anything. In this video, Jonathan’s investigations reveal a slow-motion predator that hunts and attacks its prey. Traveling the world, Jonathan investigates sea stars from the tropics to the Antarctic and uses time-lapse photography to reveal an amazing complexity to the world of the sea star. Please see the accompanying study guide for educational objectives and discussion points.

2012-07-28

200

Different angiogenesis effect of mini-TyrRS\\/mini-TrpRS by systemic administration of modified siRNAs in rats with acute myocardial infarction  

Microsoft Academic Search

We aimed to clarify the different angiogenesis effects of mini-tyrosyl-tRNA synthetase (TyrRS)\\/minitryptophanyl-tRNA synthetase\\u000a (TrpRS) in rodent primates with acute myocardial infarction, by delivering small interfering RNAs (siRNAs) systemically in\\u000a a liposomal formulation. Left coronary artery ligation was used to establish the model of acute myocardial infarction in rats;\\u000a mini-TyrRS\\/mini-TrpRS-specific siRNAs were encapsulated in stable nucleic acid lipid particles (SNALP), and

Rui Zeng; Yu-Cheng Chen; Zhi Zeng; Wei-Qiang Liu; Xiao-Xia Liu; Rui Liu; Ou Qiang; Xian Li

2010-01-01

201

Small interfering RNA knockdown of mini-TyrRS and mini-TrpRS effects angiogenesis in human umbilical vein endothelial cells in hypoxic culture  

Microsoft Academic Search

Aim We studied the role of mini-TyrRS and mini-TrpRS in angiogenesis by using small interfering RNA-mediated mini-TyrRS\\/mini-TrpRS\\u000a knockout in hypoxic culture of human umbilical vein endothelial cells. Methods SiRNA was used as the main method to inhibited the gene function. Silencing efficiency was assayed by real-time reverse transcription-polymerase\\u000a chain reaction and western blotting. The angiogenic activity in vitro was evaluated by

Rui Zeng; Yu-cheng Chen; Zhi Zeng; Rui Liu; Ou Qiang; Xiao-fei Jiang; Xiao-xia Liu; Xian Li; Hao-yu Wang

2008-01-01

202

Spatially extended emission around the Cepheid RS Puppis in near-infrared hydrogen lines. Adaptive optics imaging with VLT/NACO  

NASA Astrophysics Data System (ADS)

Context. It has been recently discovered that Cepheids harbor circumstellar envelopes (CSEs). RS Pup is the Cepheid that presents the most prominent circumstellar envelope known, the origin of which is not yet understood. Aims: Our purpose is to estimate the flux contribution of the CSE around RS Pup at the one arcsecond scale (~2000 AU) and to investigate its geometry, especially regarding asymmetries, to constrain its physical properties. Methods: We obtained near-infrared images in two narrow band filters centered on ? = 1.644 and 2.180 ?m (NB_1.64 and IB_2.18, respectively) that comprise two recombination lines of hydrogen: the 12-4 and 7-4 (Brackett ?) transitions, respectively. We used NACO's cube mode observations in order to improve the angular resolution with the shift-and-add technique, and to qualitatively study the symmetry of the spatially extended emission from the CSE with a statistical study of the speckle noise. Results: We probably detect at a 2? level an extended emission with a relative flux (compared with the star in the same filter) of 38 ± 17% in the NB_1.64 filter and 24 ± 11% in the IB_2.18 filter. This emission is centered on RS Pup and does not present any detectable asymmetry. We attribute the detected emission to the likely presence of an hydrogen envelope surrounding the star. Based on observations made with ESO telescopes at Paranal observatory under program ID 382.D-0065(A).

Gallenne, A.; Mérand, A.; Kervella, P.; Girard, J. H. V.

2011-03-01

203

Scintillating Stars  

NSDL National Science Digital Library

Often, a bright planet that is visible over the horizon will be mistaken for a star. Some believe they can tell the difference between a star and a planet because stars twinkle, or scintillate , and planets do not. In actuality however, both will twinkle because any light that passes through our atmosphere, whether it be reflected from a planet or generated by a star, will be interfered with by the atmospheric elements. This month's column sheds light on this "scintillating" subject and engages students in a research activity that revolves around the question: Is Pluto a planet?

Riddle, Bob

2003-02-01

204

Neutron Stars  

NASA Technical Reports Server (NTRS)

Neutron stars were discovered almost 40 years ago, and yet many of their most fundamental properties remain mysteries. There have been many attempts to measure the mass and radius of a neutron star and thereby constrain the equation of state of the dense nuclear matter at their cores. These have been complicated by unknown parameters such as the source distance and burning fractions. A clean, straightforward way to access the neutron star parameters is with high-resolution spectroscopy. I will present the results of searches for gravitationally red-shifted absorption lines from the neutron star atmosphere using XMM-Newton and Chandra.

Cottam, J.

2007-01-01

205

Lucky Star  

NSDL National Science Digital Library

Watch this video from Cyberchase and then play the Lucky Star game! The Lucky Star game show the will ask you math-related questions and give you four possible answers to choose from. Your goal is to answer the questions correctly and score as many points as you can. You can score points during two different rounds: the pick-a-star round and the lightning round. During the pick-a-star round you have as much time as you want to answer the questions. During the lightning round you have to think fast in order to earn the points. Good luck!

2008-01-01

206

Genomic characterization of ?RS603, a filamentous bacteriophage that is infectious to the phytopathogen Ralstonia solanacearum.  

PubMed

A filamentous bacteriophage (?), ?RS603, which is infectious to the phytopathogen Ralstonia solanacearum was isolated. ?RS603 was found to have a circular single-stranded DNA genome composed of 7679 nucleotides and to contain 13 putative open reading frames (ORFs). The ?RS603 genome showed strong similarity with those of Ralstonia phages ?RSM1 and ?RSM3, as reported by Askora et al. The ?RS603 genome had no ORFs corresponding to ORFs 2, 3, 13 and 14 (integrase) of ?RSM3. ?RS603 had an ORF that was homologous to other Ralstonia phages ?RSS0 and ?RSS1; however, ?RSM1 and ?RSM3 did not. PMID:25284202

Van, Truong Thi Bich; Yoshida, Shohei; Miki, Kaito; Kondo, Akihiro; Kamei, Kaeko

2014-12-01

207

RS Ophiuchi in Quiescence: Why Is It X-ray Faint?  

NASA Technical Reports Server (NTRS)

The short interval between successive outbursts of RS Oph strongly suggests that it has a high mass white dwarf accreting at a high rate. This, in turn, suggests the possibility of prominent X-ray emission from RS Oph in quiescence. However, archival quiescent X-ray observations of RS Oph show it to be a modest soft X-ray source but not a strong 2-10 keV X-ray source. In this aspect, RS Oph differs markedly from T CrB. We speculate on the possible mechanisms that could significantly suppress the 2-10 keV X-ray emission in RS Oph.

Mukai, Koji

2007-01-01

208

VEGF, not VEGFR2, is associated with the angiogenesis effect of mini-TyrRS/mini-TrpRS in human umbilical vein endothelial cells in hypoxia.  

PubMed

The purpose of this study was to determine the relationship between VEGF and mini-TyrRS/mini-TrpRS in angiogenesis in hypoxic culture and to begin to comprehend their mechanism in angiogenesis. We designed a VEGF gene silencing assay by using lentivirus vectors, and then western blotting was used to determine the protein expression of VEGF, VEGFR2 and pVEGFR2 in three groups in hypoxic culture at 3, 6, 12, or 24 h: (1) untransfected human umbilical vein endothelial cells (HUVECs) (Control); (2) pGCSIL-GFP lentivirus vector-transduced HUVECs (Mock); and (3) pGCSIL-shVEGF lentivirus vector-transduced HUVECs (Experimental). We also detected the effects of mini-TyrRS/mini-TrpRS peptides on HUVEC proliferation, migration and tube formation after lentivirus vector transfection and VEGFR2 antibody injection. The results indicated that expression of the mini-TyrRS protein was increased, whereas that of mini-TrpRS was specifically decreased in hypoxic culture both in control and mock groups. However, this trend in protein levels of mini-TyrRS and mini-TrpRS was lost in the experimental group after transduction with the pGCSIL-shVEGF lentivirus vector. The protein expression of VEGF was increased in hypoxic culture both in control and mock groups. After transduction with the pGCSIL-shVEGF lentivirus vector, the protein level of VEGF was noticeably decreased in the experimental group; however, for VEGFR2, the results showed no significant difference in VEGFR2 protein expression in any of the groups. For pVEGFR2, we found a distinct trend from that seen with VEGF. The protein expression of pVEGFR2 was sharply increased in hypoxic culture in the three groups. The addition of mini-TyrRS significantly promoted proliferation, migration and tube formation of HUVECs, while mini-TrpRS inhibited these processes in both control and mock groups in hypoxic culture. However, these effects disappeared after transduction with the pGCSIL-shVEGF lentivirus vector in the experimental group, but no significant difference was observed after VEGFR2 antibody injection. The protein expression of VEGF is similar to that of mini-TyrRS in hypoxic culture and plays an important role in the mini-TyrRS/mini-TrpRS-stimulated proliferation, migration and tube formation of HUVECs in hypoxia. These results also suggest that the change in mini-TyrRS and mini-TrpRS expression in hypoxic culture is not related to VEGFR2 and that some other possible mechanisms, are involved in the phosphorylation of VEGFR2. PMID:23896703

Zeng, Rui; Jiang, Xiao-Fei; Chen, Yu-Cheng; Xu, Yuan-Ning; Ma, Song-Hong; Zeng, Zhi; Liu, Rui; Qiang, Ou; Li, Xian

2014-08-01

209

Star Life  

NSDL National Science Digital Library

Visitors to this site can follow the life cycle of a star, beginning with its formation from matter exploded outward by the Big Bang, followed by its expansion into a red giant as nuclear "fuel" is consumed, and ending with its "death" in a supernova, after which it becomes a neutron star or black hole.

210

Activity in X-ray-selected late-type stars  

NASA Technical Reports Server (NTRS)

A spectroscopic study has been conducted of nine X-ray bright late-type stars selected from two Einstein X-ray surveys: the Columbia Astrophysical Laboratory Survey (five stars) and the CFA Medium Sensitivity Survey (MSS; four stars). Spectral classes were determined and radial and V sin(i) velocities were measured for the stars. Four of the Columbia Survey stars were found to be new RS CVn-type binaries. The fifth Columbia survey star was found to be an active G dwarf star without evidence for binarity. None of the four MSS stars were found to be either binaries or optically active stars. Activity in these stars was assessed by measuring the excess emission in H-alpha and the Ca II IRT (8498, 8542) lines in comparison with inactive stars of similar spectral types. A correlation was found between X-ray luminosity and V sin(i) and H-alpha line excess. The measured excess line emission in H-alpha was also correlated with V sin(i) but not with the IRT line excess.

Takalo, Leo O.; Nousek, J. A.

1988-01-01

211

High-Resolution N-Band Observations of the Nova RS Ophiuchi with the Keck Interferometer Nuller  

NASA Technical Reports Server (NTRS)

We report new observations of the nova RS Ophiuchi (RS Oph) using the Keck Interferometer Nulling Instrument, approximately 3.8 days following the most recent outburst that occurred on 2006 February 12. The Keck Interferometer Nuller (KIN) operates in K-band from 8 to 12.5 pm in a nulling mode, which means that the central broad-band interference fringe is a dark fringe - with an angular width of 25 mas at mid band - rather than the bright fringe used ill a conventional optical interferometer. In this mode the stellar light itself is suppressed by the destructive fringe, effectively enhancing the contrast of the circumstellar material located near the star. By subsequently shifting the neighboring bright fringe onto the center of the source brightness distribution and integrating, a second spatial regime dominated by light from the central portion of the source is almost simultaneously sampled. The nulling technique is the sparse aperture equivalent of the conventional corongraphic technique used in filled aperture telescopes. By fitting the unique KIK inner and outer spatial regime data, we have obtained an angular size of the mid-infrared continuum of 6.2, 4.0. or 5.4 mas for a disk profile, gaussian profile (fwhm), and shell profile respectively. The data show evidence of enhanced neutral atomic hydrogen emission located in the inner spatial regime relative to the outer regime. There is also evidence of a 9.7 micron silicate feature seen outside of this region. Importantly, we see spectral lines excited by the nova flash in the outer region before the blast wave reaches these regions. These lines are from neutral, weakly excited atoms which support the following interpretation. We discuss the present results in terms of a unifying model of the system that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star. These data show the power and potential of the nulling technique which has been developed for the detection of Earth-like planets around nearby stars for the Terrestrial Planet Finder Mission and Darwin missions.

Barry, R. K.; Danchi, W. C.; Sokoloski, J. L.; Koresko, C.; Wisniewski, J. P.; Serabyn, E.; Traub, W.; Kuchner, M.; Greenhouse, M. A.

2007-01-01

212

Genome Sequencing of Ralstonia solanacearum Biovar 3, Phylotype I, Strains Rs-09-161 and Rs-10-244, Isolated from Eggplant and Chili in India  

PubMed Central

Ralstonia solanacearum Indian strains Rs-09-161 and Rs-10-244 were isolated from the coastal region of Goa and from the Andaman Islands. We report the draft genome sequences of these representative isolates infecting solanaceous vegetables in India. PMID:24874667

Gaitonde, Sapna; Achari, Gauri; Asolkar, Trupti; Singh, Narendra Pratap; Carrere, Sebastien; Genin, Stephane; Peeters, Nemo

2014-01-01

213

Genome Sequencing of Ralstonia solanacearum Biovar 3, Phylotype I, Strains Rs-09-161 and Rs-10-244, Isolated from Eggplant and Chili in India.  

PubMed

Ralstonia solanacearum Indian strains Rs-09-161 and Rs-10-244 were isolated from the coastal region of Goa and from the Andaman Islands. We report the draft genome sequences of these representative isolates infecting solanaceous vegetables in India. PMID:24874667

Ramesh, Raman; Gaitonde, Sapna; Achari, Gauri; Asolkar, Trupti; Singh, Narendra Pratap; Carrere, Sebastien; Genin, Stephane; Peeters, Nemo

2014-01-01

214

The radion potential and supersymmetry breaking in detuned RS  

E-print Network

We study radiative corrections to the radion potential in the supersymmetric ``detuned RS model'', with supersymmetry broken by boundary conditions. Classically, the radion is stabilized in this model, and the 4d theory is AdS_4. With a few bulk hypermultiplets, the one-loop correction to the cosmological constant is positive. For small warping, this correction can (almost) cancel the classical result. The loop expansion is still reliable in this limit. The graviphoton zero-mode, which controls supersymmetry breaking, is a modulus of the classical theory, but is stabilized at one-loop. Both unbroken supersymmetry and maximal supersymmetry breaking are stable ground-states of the quantum theory.

Yael Shadmi

2006-05-28

215

RS CVn binaries: Testing the solar-stellar dynamo connection  

NASA Technical Reports Server (NTRS)

We have used the Extreme Ultraviolet Explorer satellite to study the coronal emission from the EUV-bright RS CVn binaries Sigma2 CrB, observed February 10-21, 1994, and II Peg, observed October 1-5, 1993. We present time-resolved and integrated EUV short-, medium-, and long-wavelength spectra for these binaries. Sigma2 CrB shows significant first-order emission features in the long-wavelength region. The coronal emission distributions and electron densities are estimated for those active coronae dominated by high temperature plasma.

Dempsey, R.

1995-01-01

216

Radio polarization characteristics of two RS CVn binaries  

NASA Technical Reports Server (NTRS)

The results of multifrequency epoch VLA observations of polarized radio emission from the nearby active RS CVn binaries UX Arietis and HR 1099 are reported. For both systems, there is an excellent correlation between handedness of circular polarization and frequency. Helicity reversal is almost always seen between 1.4 and 5.0 GHz, possibly due to optical depth effects. There may also be an anticorrelation between total intensity and fractional circular polarization, especially at 5 GHz. This is consistent with models in which intense flares are associated with compact selfabsorbed synchrotron sources, while the quiescent emission arises from larger gyrosynchrotron-emitting plasma.

Mutel, R. L.; Lestrade, J.-F.; Doiron, D. J.

1985-01-01

217

Exploding star  

NASA Astrophysics Data System (ADS)

Three astronomers report that the star Eta Carinae, 100 times more massive than the sun, is nearing its life expectancy and will explode sometime in the next 10,000 years. Until now, astronomers have been unable to discern whether the star was in the process of being born, was a middle-aged star with an unusual outflow of material, or an aged star about to explode.The huge star is coming to the end of what is considered a normal lifetime—about 2 million years—for a star of its size, according to Kris Davidson at the University of Minnesota, Nolan R. Walborn (presently at the Goddard Space Flight Center) of Cerro Tololo Inter-American Observatory, and Theodore R. Gull at Goddard. When Eta Carinae explodes, the astronomers report, it could emit more light than all the hundreds of billions of other stars in the galaxy for weeks. The expected explosion, or supernova, could produce a bright point of light that would be visible in broad daylight, they add.

218

rs11671784 G/A and rs895819 A/G Polymorphisms Inversely Affect Gastric Cancer Susceptibility and miR-27a Expression in a Chinese Population  

PubMed Central

Background rs895819 and rs11671784 are 2 SNPs in miR-27a that can influence the expression of mature miRNA. However, their role in gastric cancer development is still not well understood. This study aimed to determine whether these 2 polymorphisms are associated with gastric cancer risk in a Chinese population and how they influence the expression of miR-27a. Material/Methods This was a case-control study and recruited 278 gastric cases and 278 healthy matched controls. Genotyping of these 2 SNPs among the participants were performed to assess their association with gastric cancer risk. Tumor samples from 59 patients who had physical resection were used for qRT-PCR analysis of miR-27a expression. To further valid the effects of these 2 SNPs, findings of previous studies were pooled to generate integrated evidence. Results Individuals with rs895819 G variants exhibited significantly increased risk of gastric cancer, while subjects with rs11671784 A variants had significantly reduced gastric cancer risk. Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene. The subsequent meta-analysis largely confirmed the effects of these 2 SNPs on gastric cancer risk. Conclusions rs895819 and rs11671784 inversely affect gastric cancer risk and the influence was closely related to their effects on miR-27a expression. PMID:25399405

Song, Bo; Yan, Ge; Hao, Hankun; Yang, Bei

2014-01-01

219

Einstein Observatory coronal temperatures of late-type stars  

NASA Technical Reports Server (NTRS)

The results are presented of a survey of the coronal temperatures of late-type stars using the Einstein Observatory IPC. The spectral analysis shows that the frequently found one- and two-temperature descriptions are mainly influenced by the SNR of the data and that models using continuous emission measure distributions can provide equally adequate and physically more meaningful and more plausible descriptions. Intrinsic differences in differential emission measure distributions are found for four groups of stars. M dwarfs generally show evidence for high-temperature gas in conjunction with lower-temperature material, while main-sequence stars of types F and G have the high-temperature component either absent or very weak. Very hot coronae without the lower-temperature component appearing in dwarf stars are evident in most of the giant stars studied. RS CVn systems show evidence for extremely hot coronae, sometimes with no accompanying lower-temperature material.

Schmitt, J. H. M. M.; Collura, A.; Sciortino, S.; Vaiana, G. S.; Harnden, F. R., Jr.

1990-01-01

220

CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene  

PubMed Central

X-linked juvenile retinoschisis is a heritable condition of the retina in males caused by mutations in the RS1 gene. Still, the cellular function and retina-specific expression of RS1 are poorly understood. To address the latter issue, we characterized the minimal promoter driving expression of RS1 in the retina. Binding site prediction, site-directed mutagenesis, and reporter assays suggest an essential role of two nearby cone-rod homeobox (CRX)-responsive elements (CRE) in the proximal ?177/+32 RS1 promoter. Chromatin immunoprecipitation associates the RS1 promoter in vivo with CRX, the coactivators CBP, P300, GCN5 and acetylated histone H3. Transgenic Xenopus laevis expressing a green fluorescent protein (GFP) reporter under the control of RS1 promoter sequences show that the ?177/+32 fragment drives GFP expression in photoreceptors and bipolar cells. Mutating either of the two conserved CRX binding sites results in strongly decreased RS1 expression. Despite the presence of sequence motifs in the promoter, NRL and NR2E3 appear not to be essential for RS1 expression. Together, our in vitro and in vivo results indicate that two CRE sites in the minimal RS1 promoter region control retinal RS1 expression and establish CRX as a key factor driving this expression. PMID:18927113

Langmann, Thomas; Lai, Christine C. L.; Weigelt, Karin; Tam, Beatrice M.; Warneke-Wittstock, Regina; Moritz, Orson L.; Weber, Bernhard H. F.

2008-01-01

221

IFITM3 Polymorphism rs12252-C Restricts Influenza A Viruses  

PubMed Central

The IFITM3 polymorphism rs12252-C, which encodes an IFITM3 isoform (?21 IFITM3) lacking 21 amino acids at the amino terminus, has been controversially associated with poor clinical outcomes in patients with H1N1 influenza A virus (IAV) infections. In vitro studies have shown that ?21 IFITM3 loses its ability to restrict H1N1 IAV. Subsequent research has also revealed that tyrosine 20 is the key determinant for IFITM3 endocytic trafficking, which is essential for the efficient anti-viral activity of IFITM3. In contrast to previous studies, we demonstrated that both ?21 IFITM3 and an IFITM3 variant (Y20A IFITM3), in which tyrosine 20 is substituted with alanine, strongly restricted entry mediated by IAV H1, H3, H5, and H7 proteins. ?21 IFITM3 also efficiently suppressed replication of H1N1 and, to a lesser extent, H3N2 IAV. ?21 IFITM3 and Y20A IFITM3 had broader subcellular distributions than full-length IFITM3 but an abundant amount of both IFITM3 variants still localized to late endosomes and lysosomes. Our data indicate that tyrosine 20 partially regulates the subcellular localization of IFITM3 but is not functionally essential for IFITM3-mediated IAV restriction. They also suggested that mechanisms, other than viral entry restriction, might contribute to variations in clinical outcomes of H1N1 influenza associated with rs12252-C. PMID:25314048

Grotefend, Christopher Robert; Radic, Vladimir; Chung, Changik; Chung, Young-Hwa; Farzan, Michael; Huang, I-Chueh

2014-01-01

222

Information extraction of typical karst landform based on RS  

NASA Astrophysics Data System (ADS)

Guizhou Province is the most typical karst landform area of Southwest China Karst, and how to exactly extract the typical karst landform information is important to the economic development of Guizhou. Not any method based on Remote Sensing (Hereinafter referred to as RS) to extract the karst landform were reported or published. For obtaining the accuracy information of karst landform, 10 meters resolution ALOS image is used to extract the karst landform information in Guanling County of Guizhou Province in this paper. The multiscale segmentations of RS images were finished and typical of karst landform in case study area were classified with the different segmentation rules created on the eCognition Developer platform. For mostly improving the accuracy of extraction information, the experiment areas are focused on the fengcong depressions, fengcong valleys, and fenglin basins. The results show that the fengcong depressions, fengcong valleys, and fenglin basins can be respectively well extracted from the images when the segmentation scale are respectively 280, 480 and 200, shape parameter is 0.8, and tightness parameter is 0.5. We believed the research would provide an important reference to extract the karst landform information in whole Guizhou, China or global level.

Huang, Shufen; Lan, Anjun; Ma, Jiaqiong; Guo, Haixiang

2014-05-01

223

Small interfering RNA knockdown of mini-TyrRS and mini-TrpRS effects angiogenesis in human umbilical vein endothelial cells in hypoxic culture.  

PubMed

Aim We studied the role of mini-TyrRS and mini-TrpRS in angiogenesis by using small interfering RNA-mediated mini-TyrRS/mini-TrpRS knockout in hypoxic culture of human umbilical vein endothelial cells. Methods SiRNA was used as the main method to inhibited the gene function. Silencing efficiency was assayed by real-time reverse transcription-polymerase chain reaction and western blotting. The angiogenic activity in vitro was evaluated by transwell migration assay and Matrigel-induced capillary tube formation in hypoxic culture. Cell proliferation was determined by crystal violet staining. Results The results showed that levels of the mini-TyrRS/mini-TrpRS gene and protein in mock transfection group and negative control group were higher, but noticeably decreased in experimental group. However, no significant difference was detected between mock transfection group and negative control group, but there was a statistically significant difference compared with experimental group. For mini-TyrRS-siRNA group, the cell migration, tube formation and the rate of cell proliferation were respectively inhibited by (47.4, 56.3, 65.4, 73.7%), (60.5, 69.1, 75.9, 83.6%) and (40.4, 56.2, 61.2, 68.0%). For mini-TrpRS-siRNA, were respectively increased by (18.0, 33.8, 45.1, 56.4%), (18.3, 31.2, 40.3, 45.7%) and (8.4, 26.4, 38.2, 46.6%). Conclusion These results indicated that angiogenesis is either stimulated by mini-TyrRS or inhibited by mini-TrpRS in matrigel models in hypoxic culture, raising the possibility that mini-TyrRS stimulates a common downstream signaling event. Thus, naturally occurring fragments of two proteins involved in translation, TyrRS and TrpRS, have opposing activity on endothelial cell angiogenesis in the matrigel assays. The opposing activities of the two tRNA synthetases suggest tight regulation of the balance between pro- and anti-angiogenic stimuli. PMID:19002860

Zeng, Rui; Chen, Yu-Cheng; Zeng, Zhi; Liu, Rui; Qiang, Ou; Jiang, Xiao-Fei; Liu, Xiao-Xia; Li, Xian; Wang, Hao-Yu

2008-03-01

224

Accretion onto main-sequence stars. I - The transient phase  

NASA Astrophysics Data System (ADS)

A set of boundary conditions that are suitable for the study of accretion onto main-sequence stars has been derived. An important and generally neglected phenomenon is the ram pressure produced by the materials accreting onto the stellar surface. However, while important for high rates of mass accretion onto main-sequence stars, it is negligible for accretion onto both white dwarf and neutron stars. A thermal boundary condition is also provided that allows the inclusion of the accretion energy and the accretion luminosity in the evolution. These boundary conditions have been used, together with a Lagrangian, one-dimensional, hydrodynamic stellar evolution code to study mass accreting at high rates onto a main-sequence star with a mass of 1.31 solar mass, in an attempt to simulate one of the proposed scenarios for the outburst of the recurrent nova RS Ophiuchi. This study is also relevant to those members of the class of symbiotic variables that are now thought to have main-sequence stars as the mass receiver in the system. It is concluded that mass accreting onto an enlarged, massive, main-sequence star cannot be responsible for the outburst of RS Oph.

Shaviv, Giora; Starrfield, Sumner

1988-12-01

225

Classifying stars  

NSDL National Science Digital Library

You will be able to describe the H-R diagram and explain how astronomers use it. The most important characteristics for classifying stars are: a) Color b) Temperature c) Size d) Composition e) Brightness The classification scheme that we currently use is the H-R diagram which is in the Earth Science Reference Tables (ESRT). The H-R diagram groups stars by surface temperature compared to their luminosity. 1)Today you will be reading a short tutorial ...

B, Mr.

2007-11-10

226

Tycho's Star  

NASA Astrophysics Data System (ADS)

A supernova remnant in Cassiopeia, 7.7° north of ? Cas, which suddenly appeared as a brilliant naked-eye star in November 1572 and reached a maximum apparent magnitude of -3.5. Until its disappearance 16 months later, it was extensively studied by the Danish astronomer Tycho Brahe (1546-1601), who described its early appearance as follows: `Initially, the new star was brighter than any other fixe...

Murdin, P.

2000-11-01

227

STARS no star on Kauai  

SciTech Connect

The island of Kuai, home to the Pacific Missile Range Facility, is preparing for the first of a series of Star Wars rocket launches expected to begin early this year. The Strategic Defense Initiative plans 40 launches of the Stategic Target System (STARS) over a 10-year period. The focus of the tests appears to be weapons and sensors designed to combat multiple-warhead ICBMs, which will be banned under the START II Treaty that was signed in January. The focus of this article is to express the dubious value of testing the STARS at a time when their application will not be an anticipated problem.

Jones, M.

1993-04-01

228

CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene  

Microsoft Academic Search

X-linked juvenile retinoschisis is a heritable con- dition of the retina in males caused by mutations in the RS1 gene. Still, the cellular function and retina-specific expression of RS1 are poorly under- stood. To address the latter issue, we characterized the minimal promoter driving expression of RS1 in the retina. Binding site prediction, site-directed mutagenesis, and reporter assays suggest an

Thomas Langmann; Christine C. L. Lai; Karin Weigelt; Beatrice M. Tam; Regina Warneke-Wittstock; Orson L. Moritz; Bernhard H. F. Weber

2008-01-01

229

A non-LTE spectral analysis of the 3He and 4He isotopes in the HgMn star ? Cancri  

NASA Astrophysics Data System (ADS)

Aims: We present a pilot study on non-local thermodynamic equilibrium (NLTE) line-formation computations for the isotopes 3He and 4He in the mercury-manganese star ? Cancri. The impact of NLTE effects on the determination of isotopic abundances and the vertical stratification of helium in the atmosphere is investigated. Methods: Modern NLTE line-formation computations were employed to analyse a high-resolution and high signal-to-noise ratio ESO-VLT/UVES spectrum of ? Cnc. The atmospheric parameters were determined from fitting the hydrogen Balmer lines and the spectral energy distribution. Multiple He i lines were investigated, including He i ?4921 Å and ?6678 Å, which show the widest isotopic splits. Results: Half of the observed He i lines in the spectrum of ? Cnc show significant NLTE strengthening, the effects are strongest in the red lines He i?5875 Å and He i?6678 Å. NLTE abundances from individual He i lines are up to a factor of ~3 lower than LTE values. Helium is found to be stratified in the atmosphere of ? Cnc. While the LTE analysis indicates a step-like profile of the helium abundance, a gradual decrease with height is indicated by the NLTE analysis. A 3He/4He ratio of ~0.25-0.30 is found. With the available data it cannot be decided whether the two isotopes follow the same stratification profile, or not. Conclusions: This work implies that NLTE effects may be ubiquitous in the atmospheres of HgMn stars and may have a significant impact on abundance determinations and the interpretation of the vertical abundance stratification of elements. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 076.B-0055(A).Figures 3 and 4 are available in electronic form at http://www.aanda.org

Maza, Natalia L.; Nieva, María-Fernanda; Przybilla, Norbert

2014-12-01

230

Single nucleotide polymorphism rs6716901 in SLC25A12 gene is associated with Asperger syndrome  

PubMed Central

Background Autism Spectrum Conditions (ASC) are a group of developmental conditions which affect communication, social interactions and behaviour. Mitochondrial oxidative dysfunction has been suggested as a mechanism of autism based on the results of multiple genetic association and expression studies. SLC25A12 is a gene encoding a calcium-binding carrier protein that localizes to the mitochondria and is involved in the exchange of aspartate for glutamate in the inner membrane of the mitochondria regulating the cytosolic redox state. rs2056202 SNP in this gene has previously been associated with ASC. SNPs rs6716901 and rs3765166 analysed in this study have not been previously explored in association with AS. Methods We genotyped three SNPs (rs2056202, rs3765166, and rs6716901) in SLC25A12 in n?=?117 individuals with Asperger syndrome (AS) and n?=?426 controls, all of Caucasian ancestry. Results rs6716901 showed significant association with AS (P?=?0.008) after correcting for multiple testing. We did not replicate the previously identified association between rs2056202 and AS in our sample. Similarly, rs3765166 (P?=?0.11) showed no significant association with AS. Conclusion The present study, in combination with previous studies, provides evidence for SLC25A12 as involved in the etiology of AS. Further cellular and molecular studies are required to elucidate the role of this gene in ASC. PMID:24679184

2014-01-01

231

Development of a Mailing List on Variable Stars, VSNET  

NASA Astrophysics Data System (ADS)

Various usages of the Internet have been developed and made remarkable progress these years, which is now dramatically changing the style of astronomical study. Among those, the maing list is thought to be most useful to study of unpredictable objects for the characteristics, especially rapidness and equality. We started a mailing list (VSNET) on variable stars, mainly on cataclysmic variables and supernovae, in 1994 July for mutual exchange of information and ideas between astronomers including professionals and amateurs. Up to now, the various articles have been distributed, for example, calls for follow up observations of transient objects discovered in the UV or X-ray region, calls for ground-based observations simultaneous with ones by the space telescopes, discoveries of supernovae, alert notices of outbursts in long dormant dwarf novae (EG Cnc, AL Com, UZ Boo, HT Cas, etc), and so on. You can get long-term light curves of variable stars drawn using VSNET data on the VSNET web pages http://www.kusastro.kyoto-u.ac.jp/vsnet/. The archives of VSNET mails are available via VSNET web pages and anonymous ftp ftp://ftp.kusastro.kyoto-u.ac.jp/pub/vsnet/Mail/. If you have any questions and suggestions on VSNET, please feel free to contact us (vsnet-adm@kusastro.kyoto-u.ac.jp).

Nogami, D.; Kato, T.; Baba, H.; Kunjaya, C.

232

Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil.  

PubMed

Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in the TCF7L2 gene, the noncoding single nucleotide polymorphisms (SNPs) rs7903146 (C/T) and rs12255372 (G/T), with T2D. Herein, we analyzed the association of these SNPs with T2D in a population from northeastern Brazil. Our results showed that the genotype and allele frequencies in TCF7L2 rs7903146 and rs12255372 were similar in the patient and control groups (P > 0.05). In addition, the allele frequencies were not significantly associated with T2D risk [rs7903146: odds ratio (OR) = 0.95, 95% confidence interval (CI) = 0.52-1.76, P = 1.00, and rs12255372: OR = 1.38, 95%CI = 0.72-2.62, P = 0.41]. These data suggest that the TCF7L2 SNPs rs7903146 and rs12255372 may not significantly contribute to T2D susceptibility in this population. However, our results may reflect the small number of subjects. Alternatively, these results may be attributable to specific ethnic effects, as most of the previously reported associations were demonstrated with predominantly European populations. To reach a definitive conclusion on the role of such gene variants for T2D in mixed populations, additional efforts are necessary to replicate this study with larger populations from areas with more ethnic heterogeneity. PMID:25299103

Barros, C M A R; Araujo-Neto, A P; Lopes, T R; Barros, M A L; Motta, F J N; Canalle, R; Nunes, L C C; Rey, J A; Burbano, R R; Lima-Barros, M A; Yoshioka, F K N; Pinto, G R

2014-01-01

233

Energy Star  

E-print Network

ENERGY STAR ENERGY TARGETS ESL-KT-12-10-08 CATEE 2012: Clean Air Through Energy Efficiency Conference, Galveston, TX, October 9-11, 2012 POP QUIZ!!!! What is EUI?? Energy Use Intensity Do you know the EUI and any of the buildings you designed... Efficiency Conference, Galveston, TX, October 9-11, 2012 The CFLs in an ENERGY STAR qualified light fixture only need to be changed once every 8 years on average, compared with an annual ladder-climb for incandescent light bulbs. 6 CONSIDERING TIME...

Reihl, K.; Tullos, A.

2012-01-01

234

Synergistic epistasis of paraoxonase 1 (rs662 and rs85460) and apolipoprotein E4 genes in pathogenesis of Alzheimer's disease and vascular dementia.  

PubMed

Genetic polymorphism and epistasis play a role in etiopathogenesis of Alzheimer's disease (AD) and vascular dementia (VaD). In this case-control study, a total of 241 patients were included in the study to see the effect of paraoxonase 1 (PON1; rs662 and rs85460) and apolipoprotein E (ApoE) genes in altering the odds of having AD and VaD along with serum PON and lipid profile. The presence of at least 1 variant allele of rs662, but not rs85460, increased the risk of having AD by 1.8-fold (95% confidence interval [CI]: 0.97-3.40) and VaD by 3.09-fold (95% CI: 1.4-6.9). The interaction between PON1 genes (rs662 and rs85460) and ApoE genes showed synergistic epistasis in altering the odds of significantly having both AD and VaD. On the other hand, low serum level of high-density lipoprotein and low level of serum PON activity were found associated significantly (P ? .001 in both cases) only in patients with VaD as compared to healthy control. PMID:24965284

Alam, Rizwan; Tripathi, Manjari; Mansoori, Nasim; Parveen, Shama; Luthra, Kalpana; Lakshmy, Ramakrishnan; Sharma, Subhadra; Arulselvi, Subramanian; Mukhopadhyay, Asok K

2014-12-01

235

Cool stars, stellar systems, and the sun; Proceedings of the 6th Cambridge Workshop, Seattle, WA, Sept. 18-21, 1989  

NASA Technical Reports Server (NTRS)

The present conference on cool stars, stellar systems, and the sun encompasses stellar chromospheres and coronae, binary stars, the stellar evolution of contracting stars and red giants, stellar evolution abundances of the elements, mass loss and envelopes, and stellar pulsation. Specific issues addressed include theories regarding the acoustic and magnetic heating of stellar chromospheres and coronae, stellar granulation, wave heating in magnetic flux tubes, observations of the solar Ca-II lines, longitudinal-transverse magnetic tube waves in the solar atmosphere, radio emission from rapidly rotating cool giant stars, and spot temperatures and area coverages on active dwarf stars. Also addressed are the optical and UV spectra of RS-CVn stars, emission lines from T-Tauri stars, the spectroscopy of HR1614 group stars, red giants in external galaxies, the rotation of evolved stars, the transition from red giant to planetary nebula, and radiative transfer in the dynamic atmospheres of variable stars.

Wallerstein, George (editor)

1990-01-01

236

BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects  

E-print Network

BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control: Genotype Val66Met Hippocampus Control subjects Structural imaging Brain-derived neurotrophic factor (BDNF rs6265 on the BDNF gene is thought to alter activity-dependent secretion of the protein, and previous

237

Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study  

Technology Transfer Automated Retrieval System (TEKTRAN)

The objective of this study is to examine a functional variant (rs6265) in the BDNF gene interacting with dietary intake modulate obesity traits in the Boston Puerto Rican Health Study population. BDNF rs6265 was genotyped in 1147 Puerto Ricans (aged 45-75 years), and examined for association with o...

238

Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions  

PubMed Central

This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU) RS 100-coated nanostructured lipid carrier (NLC). The genistein encapsulated NLC (GEN-NLC) was produced using the melt-emulsification technique followed by surface absorption of EDU RS 100. The EDU RS 100 increased the surface zeta potential from ?7.46 mV to +13.60 mV, by uniformly forming a spherical coating outside the NLC surface, as shown by transmission electron microscopy images. The EDU RS 100 on the NLC surface effectively improved the NLC stability by inhibiting particle size growth. The obtained EDU RS 100-GEN-NLC showed extended precorneal clearance and a 1.22-fold increase in AUC (area under the curve) compared with the bare NLC in a Gamma scintigraphic evaluation. The EDU RS 100 modification also significantly increased corneal penetration producing a 3.3-fold increase in apparent permeability coefficients (Papp) compared with references. Draize and cytotoxicity testing confirmed that the developed EDU RS 100-GEN-NLC was nonirritant to ocular tissues and nontoxic to corneal cells. These results indicate that the NLC surface modified by EDU RS 100 significantly improves the NLC properties and exhibits many advantages for ocular use. PMID:25246787

Zhang, Wenji; Li, Xuedong; Ye, Tiantian; Chen, Fen; Yu, Shihui; Chen, Jianting; Yang, Xinggang; Yang, Na; Zhang, Jinsong; Liu, Jinlu; Pan, Weisan; Kong, Jun

2014-01-01

239

Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions.  

PubMed

This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU) RS 100-coated nanostructured lipid carrier (NLC). The genistein encapsulated NLC (GEN-NLC) was produced using the melt-emulsification technique followed by surface absorption of EDU RS 100. The EDU RS 100 increased the surface zeta potential from -7.46 mV to +13.60 mV, by uniformly forming a spherical coating outside the NLC surface, as shown by transmission electron microscopy images. The EDU RS 100 on the NLC surface effectively improved the NLC stability by inhibiting particle size growth. The obtained EDU RS 100-GEN-NLC showed extended precorneal clearance and a 1.22-fold increase in AUC (area under the curve) compared with the bare NLC in a Gamma scintigraphic evaluation. The EDU RS 100 modification also significantly increased corneal penetration producing a 3.3-fold increase in apparent permeability coefficients (Papp) compared with references. Draize and cytotoxicity testing confirmed that the developed EDU RS 100-GEN-NLC was nonirritant to ocular tissues and nontoxic to corneal cells. These results indicate that the NLC surface modified by EDU RS 100 significantly improves the NLC properties and exhibits many advantages for ocular use. PMID:25246787

Zhang, Wenji; Li, Xuedong; Ye, Tiantian; Chen, Fen; Yu, Shihui; Chen, Jianting; Yang, Xinggang; Yang, Na; Zhang, Jinsong; Liu, Jinlu; Pan, Weisan; Kong, Jun

2014-01-01

240

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome: ultrasonography as a diagnostic tool  

Microsoft Academic Search

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is characterized by symmetrical synovitis and swelling of both the upper and lower extremities. The anatomical determinant of RS3PE is predominantly extensor tenosynovitis as revealed by magnetic resonance imaging (MRI). Given the cost constraints, time, and expertise required in carrying out MRI and ease in diagnosing tenosynovitis by ultrasound, we utilized

Vikas Agarwal; Ajay Kumar Dabra; Ravinder Kaur; Atul Sachdev; Ram Singh

2005-01-01

241

Magnetic topology and surface differential rotation on the K1 subgiant of the RS CVn system HR 1099  

E-print Network

We present here spectropolarimetric observations of the RS CVn system HR 1099 (V711 Tau) secured from 1998 February to 2002 January with the spectropolarimeter MuSiCoS at the Telescope Bernard Lyot (Observatoire du Pic du Midi, France). We apply Zeeman-Doppler Imaging and reconstruct brightness and magnetic surface topologies of the K1 primary subgiant of the system, at five different epochs. We confirm the presence of large, axisymmetric regions where the magnetic field is mainly azimuthal, providing further support to the hypothesis that dynamo processes may be distributed throughout the whole convective zone in this star. We study the short-term evolution of surface structures from a comparison of our images with observations secured at close-by epochs by Donati et al. (2003) at the Anglo-Australian Telescope. We conclude that the small-scale brightness and magnetic patterns undergo major changes within a timescale of 4 to 6 weeks, while the largest structures remain stable over several years. We report the detection of a weak surface differential rotation (both from brightness and magnetic tracers) indicating that the equator rotates faster than the pole with a difference in rotation rate between the pole and the equator about 4 times smaller than that of the Sun. This result suggests that tidal forces also impact the global dynamic equilibrium of convective zones in cool active stars.

P. Petit; J. -F. Donati; G. A. Wade; J. D. Landstreet; S. Bagnulo; T. Lueftinger; T. A. A. Sigut; S. L. S. Shorlin; S. Strasser; M. Auriere; J. M. Oliveira

2003-12-09

242

Star Power  

ScienceCinema

The U.S. Department of Energy's Princeton Plasma Physics Laboratory has released ''Star Power,'' a new informational video that uses dramatic and beautiful images and thought-provoking interviews to highlight the importance of the Laboratory's research into magnetic fusion.

None

2014-11-18

243

Star Power  

NSDL National Science Digital Library

In this activity, learners create a star show and discover how they can prevent light pollution. Using simple materials, learners first design constellation boxes. Next, learners use their constellation boxes and desk lamps to explore how city lights impact the visibility of constellations. Finally, learners design shields to reduce light pollution and increase the visibility of constellations.

Twin Cities Public Television

2010-01-01

244

Brittle Star  

USGS Multimedia Gallery

A tiny brittle star (the central disc is smaller than a dime) clings to the branches of a soft coral in a sample bucket brought into the shipboard laboratory from a submersible dive. This creature makes its home on the deep, dark ocean floor. ...

245

Star Power  

SciTech Connect

The U.S. Department of Energy's Princeton Plasma Physics Laboratory has released ''Star Power,'' a new informational video that uses dramatic and beautiful images and thought-provoking interviews to highlight the importance of the Laboratory's research into magnetic fusion.

None

2014-10-17

246

STAR Highlights  

E-print Network

We report selected results from STAR collaboration at RHIC, focusing on jet-hadron and jet-like correlations, quarkonium suppression and collectivity, di-electron spectrum in both p+p and Au+Au, and higher moments of net-protons as well as azimuthal anisotropy from RHIC Beam Energy Scan program.

Hiroshi Masui; for the STAR Collaboration

2011-06-29

247

Two-Component Signal Transduction System SaeRS Positively Regulates Staphylococcus epidermidis Glucose Metabolism  

PubMed Central

Staphylococcus epidermidis, which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two-component signal transduction system SaeRS. In this study, we performed a proteomic analysis of differences in expression between the S. epidermidis 1457 wild-type and saeRS mutant to identify candidates regulated by saeRS using two-dimensional gel electrophoresis (2-DE) combined with matrix-assisted laser desorption/lonization mass spectrometry (MALDI-TOF-MS). Of 55 identified proteins that significantly differed in expression between the two strains, 15 were upregulated and 40 were downregulated. The downregulated proteins included enzymes related to glycolysis and TCA cycle, suggesting that glucose is not properly utilized in S. epidermidis when saeRS was deleted. The study will be helpful for treatment of S. epidermidis infection from the viewpoint of metabolic modulation dependent on two-component signal transduction system SaeRS. PMID:24592198

Qi, Yijun; Ma, Yuanfang; Qu, Di

2014-01-01

248

A lack of association between the CRP rs2794520 polymorphism and coronary artery disease  

PubMed Central

Coronary artery disease (CAD) is mainly caused by atherosclerosis, which is closely associated with the C-reactive protein (CRP), a systemic inflammatory mediator. The aim of the present study was to examine whether the CRP rs2794520 polymorphism played a role in the risk of CAD. A total of 459 CAD patients and 432 non-CAD controls were recruited in the case-control study. Genotyping was performed on the SEQUENOM® Mass-ARRAY iPLEX® platform according to the manufacturer's instructions. The results showed that CRP rs2794520 was not associated with CAD. A further breakdown analysis by age or gender also indicated a lack of association between rs2794520 and CAD. In addition, the CRP rs2794520 polymorphism was not associated with the severity of CAD, which was represented by the number of coronary arteries with stenosis. In conclusion, there was no contribution of the CRP rs2794520 polymorphism to the risk of CAD. PMID:25469258

LIAN, JIANGFANG; LI, JUNXING; DAI, DONGJUN; FANG, PEILIANG; ZHOU, JIANQING; DUAN, SHIWEI

2015-01-01

249

Association of CHKA polymorphism (rs3794186) with ?-fetoprotein levels in hepatocellular carcinoma.  

PubMed

Choline kinase ? (CHKA) has been identified to be associated with cancer development and progression. In this study, we investigated whether exonic single nucleotide polymorphisms (SNPs) of the CHKA gene are associated with hepatocellular carcinoma (HCC). Among all SNPs in the 3'-untranslated region (UTR), 5'-UTR and the coding region of CHA, only two SNPs (rs3794186 and rs11481) in the 3'-UTR had a heterozygosity above 0.1 and a minor allele frequency above 0.1. Therefore, we selected and assessed these two SNPs (rs3794186 and rs11481) in 189 HCC patients and 194 controls. Genetic data were analyzed using the SNPAnalyzer Pro, SNPStats and Haploview programs. No SNPs of the CHKA gene were found to be associated with the risk of HCC development. Upon analysis of the clinical characteristics of HCC, the genotypic frequency of rs3794186 was significantly associated with serum ?-fetoprotein (AFP) levels (P=0.022 in the co-dominant 1 model, P=0.0045 in the dominant model and P=0.0052 in the log-additive model). A significant difference in the allelic frequency of rs3794186 was also observed between the high AFP (>200 ng/ml) group and the low AFP (?200 ng/ml) group [P=0.009, odds ratio (OR) = 0.33, 95% confidence interval (95% CI) = 0.14-0.75]. The T allele frequency of rs3794186 was lower in the high AFP group (6.6%) compared to that in the low AFP group (17.8%). Our results suggest that CHKA SNPs (rs3794186 and rs11481) are not associated with HCC development; however, rs3794186 may correlate with serum AFP levels in HCC. PMID:22972156

Park, Min-Su; Kim, Su Kang; Shin, Hyun Phil; Lee, Sang Mok; Chung, Joo-Ho

2012-12-01

250

Study on parallel and distributed management of RS data based on spatial data base  

NASA Astrophysics Data System (ADS)

With the rapid development of current earth-observing technology, RS image data storage, management and information publication become a bottle-neck for its appliance and popularization. There are two prominent problems in RS image data storage and management system. First, background server hardly handle the heavy process of great capacity of RS data which stored at different nodes in a distributing environment. A tough burden has put on the background server. Second, there is no unique, standard and rational organization of Multi-sensor RS data for its storage and management. And lots of information is lost or not included at storage. Faced at the above two problems, the paper has put forward a framework for RS image data parallel and distributed management and storage system. This system aims at RS data information system based on parallel background server and a distributed data management system. Aiming at the above two goals, this paper has studied the following key techniques and elicited some revelatory conclusions. The paper has put forward a solid index of "Pyramid, Block, Layer, Epoch" according to the properties of RS image data. With the solid index mechanism, a rational organization for different resolution, different area, different band and different period of Multi-sensor RS image data is completed. In data storage, RS data is not divided into binary large objects to be stored at current relational database system, while it is reconstructed through the above solid index mechanism. A logical image database for the RS image data file is constructed. In system architecture, this paper has set up a framework based on a parallel server of several common computers. Under the framework, the background process is divided into two parts, the common WEB process and parallel process.

Chen, Yingbiao; Qian, Qinglan; Liu, Shijin

2006-12-01

251

The rs3768777-G allele of ITGAV gene is associated with rheumatoid arthritis.  

PubMed

Integrin ?v?3 (vitronectin receptor) plays a prominent role in angiogenesis, a key pathogenic feature of rheumatoid arthritis (RA). Moreover, integrin ?V (ITGAV) subunit gene has been associated with a susceptibility to RA. The aim of the present study was to detect the potential association between ITGAV gene polymorphisms and a susceptibility to RA in a Turkish cohort. DNA samples were harvested from 160 patients with RA and 144 healthy controls (HC). Three single-nucleotide polymorphisms of ITGAV gene (rs3738919, rs3768777, and rs10174098) were genotyped using real-time PCR. Serum vitronectin levels were analyzed in 30 RA patients, 28 Behçet's disease (BD) patients, and 30 HC subjects. There was no significant difference between the RA and HC groups in terms of the genotypic and allelic distributions of rs3738919 and rs10174098 polymorphisms. However, the prevalence of rs3768777-G allele was higher in the RA group than in the HC group (OR 2.3, 95 % CI 1.6-3.2, p < 0.0001). Moreover, there was a significant association between RA and the genotypic distribution of rs3768777 (GG + AG vs. AA: OR 2.1, 95 % CI 1.3-3.4; GG vs. AG + AA: OR 4.1, 95 % CI 2.1-7.8). Serum vitronectin levels were lower in the RA and BD groups than in the HC group (p ANOVA = 0.002). The rs3738919 and rs10174098 polymorphisms of the ITGAV gene seem not to be associated with susceptibility to RA in Turkish patients. However, rs3768777 increases the risk of RA in this group. These results suggest that the ITGAV gene may be a candidate gene for the etiopathogenesis of RA. PMID:24375314

Koca, Suleyman Serdar; Kara, Murat; Ozgen, Metin; Dagli, Mustafa Necati; Gozel, Nevzat; Yolbas, Servet; Gundogdu, Baris; Kargun, Kursat; Isik, Ahmet

2014-05-01

252

Assessment of Leptin Gene Polymorphism rs2060713 in Psoriasis Vulgaris  

PubMed Central

Psoriasis is a lifelong disorder characterized by approximately 8-fold reduction of the duration of normal skin keratinocyte cell cycle and 2-fold increase of the number of dividing cells. Multiple genes, several environmental factors, and immune system alterations are involved in the pathogenesis of psoriasis. Hyperleptinemia is associated with psoriasis and leptin acts as an angiogenic factor. Angiogenetic processes precede the epidermal hyperplasia in psoriasis, indicating possible involvement of leptin in the pathogenesis of psoriasis. Leptin gene polymorphisms and their association with psoriasis have been given very little attention. We present a study of the rs2060713C/T genetic polymorphism in the pathogenesis of psoriasis vulgaris in 263 vulgaris patients and 252 unrelated matched healthy controls. No statistically significant differences were observed between patients and controls. A statistically nonsignificant trend was observed in males with the early onset type of psoriasis (11.1% C/T in patients versus 5.6% in controls) and in females with the late onset type of the disease (12.8% C/T in patients versus 3.3% in controls). Still, there is no hard evidence on correlation of psoriasis vulgaris with this polymorphism. Possible association with specific forms of the disease and either gender needs further investigation in larger studies. PMID:24600521

Karpouzis, Anthony; Tripsianis, Gregory

2014-01-01

253

Rapid Pneumatic Transport of Radioactive Samples - RaPToRS  

NASA Astrophysics Data System (ADS)

Some ICF neutron activation diagnostics require quick retrieval of the activated sample. Minimizing retrieval times is particularly important when the half-life of the activated material is on the order of the transport time or the degree of radioactivity is close to the background counting level. These restrictions exist in current experiments performed at the Laboratory for Laser Energetics, thus motivating the development of the RaPToRS system. The system has been designed to minimize transportation time while requiring no human intervention during transport or counting. These factors will be important if the system is to be used at the NIF where radiological hazards will be present during post activation. The sample carrier is pneumatically transported via a 4 inch ID PVC pipe to a remote location in excess of 100 meters from the activation site at a speed of approximately 7 m/s. It arrives at an end station where it is dismounted robotically from the carrier and removed from its hermetic package. The sample is then placed by the robot in a counting station. This system is currently being developed to measure back-to-back gamma rays produced by positron annihilation which were emitted by activated graphite. Funded in part by the U.S. DOE under sub contract with LLE at the University of Rochester.

Padalino, S.; Barrios, M.; Sangster, C.

2005-10-01

254

Two component X-ray emission from RS CVn binaries  

NASA Technical Reports Server (NTRS)

A summary of results from the solid state spectrometer on the Einstein Observatory for 7 RS CVn binaries is presented. The spectra of all require two emission components, evidenced by line emission characteristic of plasma at 4 to 8 x 10 to the 6th power and bremsstrahlung characteristic of 20 to 100 x 10 to the 6th power K. The data are interpreted in terms of magnetic coronal loops similar to those seen on the Sun, although with different characteristic parameters. The emission regions could be defined by separate magnetic structures. For pressure less than approximately 10 dynes/sq cm the low temperature plasma would be confined within the stellar radii, while the high temperature plasma would, for the synchronous close binaries, fill the binary orbits. However, for loop pressures exceeding 100 dynes/sq cm, the high temperature components would also be confined to within the stellar radii, in loops covering only small fractions of the stellar surfaces. While the radio properties and the occurrence of X-ray flares suggest the larger emission regions, the observations of time variations leave the ambiguity unresolved.

Swank, J. H.; White, N. E.; Holt, S. S.; Becker, R. H.

1980-01-01

255

Spectroscopy: Star Light, Star Bright  

NSDL National Science Digital Library

This is a student reading about the different types of spectra: continuous, absorption, and emission. Learners will read about the differences between each and see graphical representations of each. This activity is from the Stanford Solar Center's All About the Sun: Sun and Stars activity guide for Grades 5-8 and can also accompany the Stanford Solar Center's Build Your Own Spectroscope activity.

256

The rs1024611 Regulatory Region Polymorphism Is Associated with CCL2 Allelic Expression Imbalance  

PubMed Central

CC chemokine ligand 2 (CCL2) is the most potent monocyte chemoattractant and inter-individual differences in its expression level have been associated with genetic variants mapping to the cis-regulatory regions of the gene. An A to G polymorphism in the CCL2 enhancer region at position –2578 (rs1024611; A>G), was found in most studies to be associated with higher serum CCL2 levels and increased susceptibility to a variety of diseases such as HIV-1 associated neurological disorders, tuberculosis, and atherosclerosis. However, the precise mechanism by which rs1024611influences CCL2 expression is not known. To address this knowledge gap, we tested the hypothesis that rs1024611G polymorphism is associated with allelic expression imbalance (AEI) of CCL2. We used haplotype analysis and identified a transcribed SNP in the 3?UTR (rs13900; C>T) can serve as a proxy for the rs1024611 and demonstrated that the rs1024611G allele displayed a perfect linkage disequilibrium with rs13900T allele. Allele-specific transcript quantification in lipopolysaccharide treated PBMCs obtained from heterozygous donors showed that rs13900T allele were expressed at higher levels when compared to rs13900C allele in all the donors examined suggesting that CCL2 is subjected to AEI and that that the allele containing rs1024611G is preferentially transcribed. We also found that AEI of CCL2 is a stable trait and could be detected in newly synthesized RNA. In contrast to these in vivo findings, in vitro assays with haplotype-specific reporter constructs indicated that the haplotype bearing rs1024611G had a lower or similar transcriptional activity when compared to the haplotype containing rs1024611A. This discordance between the in vivo and in vitro expression studies suggests that the CCL2 regulatory region polymorphisms may be functioning in a complex and context-dependent manner. In summary, our studies provide strong functional evidence and a rational explanation for the phenotypic effects of the CCL2 rs1024611G allele. PMID:23166687

Pham, Minh-Hieu T.; Bonello, Gregory B.; Castiblanco, John; Le, Tuan; Sigala, Jose; He, Weijing; Mummidi, Srinivas

2012-01-01

257

The rs1024611 regulatory region polymorphism is associated with CCL2 allelic expression imbalance.  

PubMed

CC chemokine ligand 2 (CCL2) is the most potent monocyte chemoattractant and inter-individual differences in its expression level have been associated with genetic variants mapping to the cis-regulatory regions of the gene. An A to G polymorphism in the CCL2 enhancer region at position -2578 (rs1024611; A>G), was found in most studies to be associated with higher serum CCL2 levels and increased susceptibility to a variety of diseases such as HIV-1 associated neurological disorders, tuberculosis, and atherosclerosis. However, the precise mechanism by which rs1024611influences CCL2 expression is not known. To address this knowledge gap, we tested the hypothesis that rs1024611G polymorphism is associated with allelic expression imbalance (AEI) of CCL2. We used haplotype analysis and identified a transcribed SNP in the 3'UTR (rs13900; C>T) can serve as a proxy for the rs1024611 and demonstrated that the rs1024611G allele displayed a perfect linkage disequilibrium with rs13900T allele. Allele-specific transcript quantification in lipopolysaccharide treated PBMCs obtained from heterozygous donors showed that rs13900T allele were expressed at higher levels when compared to rs13900C allele in all the donors examined suggesting that CCL2 is subjected to AEI and that that the allele containing rs1024611G is preferentially transcribed. We also found that AEI of CCL2 is a stable trait and could be detected in newly synthesized RNA. In contrast to these in vivo findings, in vitro assays with haplotype-specific reporter constructs indicated that the haplotype bearing rs1024611G had a lower or similar transcriptional activity when compared to the haplotype containing rs1024611A. This discordance between the in vivo and in vitro expression studies suggests that the CCL2 regulatory region polymorphisms may be functioning in a complex and context-dependent manner. In summary, our studies provide strong functional evidence and a rational explanation for the phenotypic effects of the CCL2 rs1024611G allele. PMID:23166687

Pham, Minh-Hieu T; Bonello, Gregory B; Castiblanco, John; Le, Tuan; Sigala, Jose; He, Weijing; Mummidi, Srinivas

2012-01-01

258

Converting neutron stars into strange stars  

NASA Technical Reports Server (NTRS)

If strange matter is formed in the interior of a neutron star, it will convert the entire neutron star into a strange star. The proposed mechanisms are reviewed for strange matter seeding and the possible strange matter contamination of neutron star progenitors. The conversion process that follows seeding and the recent calculations of the conversion timescale are discussed.

Olinto, A. V.

1991-01-01

259

Star formation and the ages of stars  

NASA Astrophysics Data System (ADS)

In this contribution we illustrate how the knowledge of the ages of stars is important to constrain star formation processes. We focus on two specific cases: star formation around the supermassive black hole at the center of the Galaxy and triggered star formation on the borders of Hii regions.

Martins, F.

2014-11-01

260

Stars : the end of a star  

NSDL National Science Digital Library

What happens during the death of a star? This activity page, part of an interactive laboratory series for grades 8-12, introduces students to the final processes of stars. Here students read about low-mass, medium-mass, and massive stars. Low-mass stars produce white dwarfs. A pop-up window describes how white dwarfs form. Medium-mass stars produce neutron stars and supernova. Pop-up information explains the supernova process. Massive stars undergo carbon burning. An interactive lab activity presents students the opportunity to predict temperature, pressure, and gravity changes that occur during carbon fusion. In a final lab activity, students compare initial star size with the type of death that occurs. Activity questions about star death are provided for each star size and are recordable and printable. Copyright 2005 Eisenhower National Clearinghouse

University of Utah. Astrophysics Science Project Integrating Research and Education (ASPIRE)

2003-01-01

261

Preparation of Fe(3)O(4)@C@CNC multifunctional magnetic core/shell nanoparticles and their application in a signal-type flow-injection photoluminescence immunosensor.  

PubMed

We describe here the preparation of carbon-coated Fe3O4 magnetic nanoparticles that were further fabricated into multifunctional core/shell nanoparticles (Fe3O4@C@CNCs) through a layer-by-layer self-assembly process of carbon nanocrystals (CNCs). The nanoparticles were applied in a photoluminescence (PL) immunosensor to detect the carcinoembryonic antigen (CEA), and CEA primary antibody was immobilized onto the surface of the nanoparticles. In addition, CEA secondary antibody and glucose oxidase were covalently bonded to silica nanoparticles. After stepwise immunoreactions, the immunoreagent was injected into the PL cell using a flow-injection PL system. When glucose was injected, hydrogen peroxide was obtained because of glucose oxidase catalysis and quenched the PL of the Fe3O4@C@CNC nanoparticles. The here proposed PL immunosensor allowed us to determine CEA concentrations in the 0.005–50 ng·mL-1 concentration range, with a detection limit of 1.8 pg·mL-1. PMID:24121430

Chu, Chengchao; Li, Meng; Li, Long; Ge, Shenguang; Ge, Lei; Yu, Jinghua; Yan, Mei; Song, Xianrang

2013-11-01

262

Association of HSPA1B SNP rs6457452 with Alopecia Areata in the Korean population.  

PubMed

The heat shock 70?kDa protein 1B (HSPA1B), which has been well-studied among the famous heat shock proteins HSPA1A/B/L, is related to autoimmune diseases, including Alopecia Areata (AA). In this study, the association of a 5'-untranslated region (5'UTR) SNP rs6457452 and a promoter SNP rs2763979 (-1140C?>?T) of HSPA1B with AA was investigated in 236 controls and 228 AA patients. Statistical analyses using the multiple logistic models were done, according to the onset and the clinical features of AA, including the age of onset, family history, type of AA lesion, nail involvement and body hair involvement. The results showed that rs6457452 was associated with the onset of AA (p?rs6457452 was weakly related to the age of onset (p???0.04) and that rs2763979 was only weakly related to the type of AA lesion (p?=?0.041). In conclusion, we suggest that the 5'UTR SNP rs6457452 of HSPA1B may be associated with the onset of AA and the T allele of rs6457452 may confer the reduced susceptibility to AA in the Korean population. PMID:24303776

Seok, Hosik; Jeon, Hye Sook; Park, Hae Jeong; Kim, Su Kang; Choi, Jeong Hwee; Lew, Bark-Lynn; Chung, Joo-Ho; Sim, Woo-Young

2014-01-01

263

Association between miR-125a rs12976445 and survival in breast cancer patients  

PubMed Central

MicroRNAs (miRNAs) act as an oncogene or a tumor suppressor by negatively regulating target genes. Genetic variants in miRNA genes confer susceptibility to cancer and risk of death in cancer patients. The aim of this study was to investigate whether miRNA polymorphisms were associated with survival in breast cancer patients. Five miRNA polymorphisms (miR-26a1 rs7372209, miR-125a rs12976445, miR-218 rs11134527, miR-423 rs6505162, and miR-608 rs4919510) were genotyped in 196 breast cancer patients. We found that miR-125a rs12976445 was significantly associated with survival in codominant, recessive, and dominant models. However, only association under the codominant model remained significant after adjustment for lymph node metastasis, TNM stage, estrogen receptor, and progesterone receptor. Furthermore, this effect remained in stratification analysis. In conclusion, our results provide evidence that miR-125a rs12976445 may serve as a prognostic biomarker for breast cancer. Further large-scale studies are required to confirm these findings.

Jiao, Lianghe; Zhang, Jiaxin; Dong, Yuanyuan; Duan, Bensong; Yu, Hong; Sheng, Haihui; Huang, Junxing; Gao, Hengjun

2014-01-01

264

The Two-Component System GrvRS (EtaRS) Regulates ace Expression in Enterococcus faecalis OG1RF.  

PubMed

Expression of ace (adhesin to collagen of Enterococcus faecalis), encoding a virulence factor in endocarditis and urinary tract infection models, has been shown to increase under certain conditions, such as in the presence of serum, bile salts, urine, and collagen and at 46°C. However, the mechanism of ace/Ace regulation under different conditions is still unknown. In this study, we identified a two-component regulatory system GrvRS as the main regulator of ace expression under these stress conditions. Using Northern hybridization and ?-galactosidase assays of an ace promoter-lacZ fusion, we found transcription of ace to be virtually absent in a grvR deletion mutant under the conditions that increase ace expression in wild-type OG1RF and in the complemented strain. Moreover, a grvR mutant revealed decreased collagen binding and biofilm formation as well as attenuation in a murine urinary tract infection model. Here we show that GrvR plays a major role in control of ace expression and E. faecalis virulence. PMID:25385790

Roh, Jung Hyeob; Singh, Kavindra V; La Rosa, Sabina Leanti; Cohen, Ana Luisa V; Murray, Barbara E

2015-01-01

265

The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers  

PubMed Central

A compromised brain reward system has been postulated as a key feature of drug dependence. We examined whether several polymorphisms of genes found to regulate nicotinic acetylcholine receptor (nAChR) and dopamine expression were related to an intrinsic reward sensitivity (IRS) deficit we previously identified among a subgroup of smokers using event-related potentials (ERPs). We examined genetic polymorphisms within the CHRNA5-A3-B4 gene cluster (CHRNA3 rs578776, CHRNA5 rs16969968, LOC123688 rs8034191, and CHRNA3 rs1051730), the ANKK1 gene (rs1800497), and the D2 dopamine receptor gene (DRD2 rs1079597, DRD2 rs1799732) from 104 smokers of European ancestry in a smoking cessation trial. Prior to treatment, we recorded ERPs evoked by emotional (both pleasant and unpleasant), neutral, and cigarette-related pictures. Smokers were assigned to two groups (IRS+/IRS?) based on the amplitude of the late positive potential (LPP) component to the pictures, a neural marker of motivational salience. Smokers (n?=?42) with blunted brain responses to intrinsically rewarding (pleasant) pictures and enhanced responses to cigarette pictures were assigned to the IRS? group, while smokers (n?=?62) with the opposite pattern of LPP responding were assigned to the IRS+ group. Carriers of the protective minor T allele (T/T, C/T) of the CHRNA3 rs578776 were less likely to be members of the IRS? group than those homozygous for the at-risk C allele (C/C). The CHRNA3 rs578776 polymorphism did not differ on questionnaires of nicotine dependence, depressed mood, or trait affective disposition and did not predict abstinence at 6?months after the quit date. These results suggest that polymorphisms of genes influencing nAChR expression are related to an endophenotype of reward sensitivity in smokers. PMID:24065931

Robinson, Jason D.; Versace, Francesco; Lam, Cho Y.; Minnix, Jennifer A.; Engelmann, Jeffrey M.; Cui, Yong; Karam-Hage, Maher; Shete, Sanjay S.; Tomlinson, Gail E.; Chen, Tina T.-L.; Wetter, David W.; Green, Charles E.; Cinciripini, Paul M.

2013-01-01

266

The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction  

PubMed Central

Background Abnormal lipids is one of the critical risk factors for myocardial infarction (MI), however the role of genetic variants in lipid metabolism-related genes on MI pathogenesis still requires further investigation. We herein genotyped three SNPs (LRP6 rs2302685, LDLRAP1 rs6687605, SOAT1 rs13306731) in lipid metabolism-related genes, aimed to shed light on the influence of these SNPs on individual susceptibility to MI. Methods Genotyping of the three SNPs (rs2302685, rs6687605 and rs13306731) was performed in 285 MI cases and 650 control subjects using polymerase chain reaction–ligation detection reaction (PCR–LDR) method. The association of these SNPs with MI and lipid profiles was performed with SPSS software. Results Multivariate logistic regression analysis showed that C allele (OR?=?1.62, P?=?0.039) and the combined CT/CC genotype (OR?=?1.67, P?=?0.035) of LRP6 rs2302685 were associated with increased MI risk, while the other two SNPs had no significant effect. Further stratified analysis uncovered a more evident association with MI risk among younger subjects (?60 years old). Fascinatingly, CT/CC genotype of rs2302685 conferred increased LDL-C levels compared to TT genotype (3.0 mmol/L vs 2.72 mmol/L) in younger subjects. Conclusions Our data provides the first evidence that LRP6 rs2302685 polymorphism is associated with an increased risk of MI in Chinese subjects, and the association is more evident among younger individuals, which probably due to the elevated LDL-C levels. PMID:24906453

2014-01-01

267

Cephalopods in neuroscience: regulations, research and the 3Rs.  

PubMed

Cephalopods have been utilised in neuroscience research for more than 100 years particularly because of their phenotypic plasticity, complex and centralised nervous system, tractability for studies of learning and cellular mechanisms of memory (e.g. long-term potentiation) and anatomical features facilitating physiological studies (e.g. squid giant axon and synapse). On 1 January 2013, research using any of the about 700 extant species of "live cephalopods" became regulated within the European Union by Directive 2010/63/EU on the "Protection of Animals used for Scientific Purposes", giving cephalopods the same EU legal protection as previously afforded only to vertebrates. The Directive has a number of implications, particularly for neuroscience research. These include: (1) projects will need justification, authorisation from local competent authorities, and be subject to review including a harm-benefit assessment and adherence to the 3Rs principles (Replacement, Refinement and Reduction). (2) To support project evaluation and compliance with the new EU law, guidelines specific to cephalopods will need to be developed, covering capture, transport, handling, housing, care, maintenance, health monitoring, humane anaesthesia, analgesia and euthanasia. (3) Objective criteria need to be developed to identify signs of pain, suffering, distress and lasting harm particularly in the context of their induction by an experimental procedure. Despite diversity of views existing on some of these topics, this paper reviews the above topics and describes the approaches being taken by the cephalopod research community (represented by the authorship) to produce "guidelines" and the potential contribution of neuroscience research to cephalopod welfare. PMID:24385049

Fiorito, Graziano; Affuso, Andrea; Anderson, David B; Basil, Jennifer; Bonnaud, Laure; Botta, Giovanni; Cole, Alison; D'Angelo, Livia; De Girolamo, Paolo; Dennison, Ngaire; Dickel, Ludovic; Di Cosmo, Anna; Di Cristo, Carlo; Gestal, Camino; Fonseca, Rute; Grasso, Frank; Kristiansen, Tore; Kuba, Michael; Maffucci, Fulvio; Manciocco, Arianna; Mark, Felix Christopher; Melillo, Daniela; Osorio, Daniel; Palumbo, Anna; Perkins, Kerry; Ponte, Giovanna; Raspa, Marcello; Shashar, Nadav; Smith, Jane; Smith, David; Sykes, António; Villanueva, Roger; Tublitz, Nathan; Zullo, Letizia; Andrews, Paul

2014-03-01

268

The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy.  

PubMed

Gene variants in MC4R, SIRT1 and FTO are associated with severe obesity and metabolic impairment in Caucasians. We investigated whether common variants in these genes are associated with metabolic syndrome (MetS) in a large group of morbidly obese young adults from southern Italy. One thousand morbidly obese subjects (62% women, mean body mass index 46.5 kg/m(2), mean age 32.6 years) whose families had lived in southern Italy for at least 2 generations were recruited. Single-nucleotide polymorphisms (SNPs) rs12970134, rs477181, rs502933 (MC4R locus), rs3818292, rs7069102, rs730821, rs2273773, rs12413112 (SIRT1 locus) and rs1421085, rs9939609, 9930506, 1121980 (FTO locus) were genotyped by Taqman assay; blood parameters were assayed by routine methods; the Fat Mass, Fat Free Mass, Respiratory Quotient, Basal Metabolic Rate (BMR) and waist circumference were also determined. Binomial logistic regression showed that the TA heterozygous genotype of SNP rs9939609 in the FTO gene was associated with the presence of MetS in our population [OR (95% CI): 2.53 (1.16-5.55)]. Furthermore, the FTO rs9939609 genotype accounted for 21.3% of the MetS phenotype together with total cholesterol, BMR and age. Our results extend the knowledge on genotype susceptibility for MetS in relation to a specific geographical area of residence. PMID:24675148

Liguori, Rosario; Labruna, Giuseppe; Alfieri, Andreina; Martone, Domenico; Farinaro, Eduardo; Contaldo, Franco; Sacchetti, Lucia; Pasanisi, Fabrizio; Buono, Pasqualina

2014-08-01

269

78 FR 20386 - Notice of Receipt of Petition for Decision That Nonconforming 2012 Porsche GT3RS Passenger Cars...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Nonconforming 2012 Porsche GT3RS Passenger Cars Are Eligible for Importation AGENCY: National...nonconforming 2012 Porsche GT3RS passenger cars that were not originally manufactured to...nonconforming 2012 Porsche GT3RS passenger cars are eligible for importation into the...

2013-04-04

270

RS-34 (Peacekeeper Post Boost Propulsion System) Orbital Debris Application Concept Study  

NASA Technical Reports Server (NTRS)

The Advanced Concepts Office (ACO) at the NASA Marshall Space Flight Center (MSFC) lead a study to evaluate the Rocketdyne produced RS-34 propulsion system as it applies to an orbital debris removal design reference mission. The existing RS-34 propulsion system is a remaining asset from the de-commissioned United States Air Force Peacekeeper ICBM program; specifically the pressure-fed storable bi-propellant Stage IV Post Boost Propulsion System. MSFC gained experience with the RS-34 propulsion system on the successful Ares I-X flight test program flown in the Ares I-X Roll control system (RoCS). The heritage hardware proved extremely robust and reliable and sparked interest for further utilization on other potential in-space applications. Subsequently, MSFC is working closely with the USAF to obtain all the remaining RS-34 stages for re-use opportunities. Prior to pursuit of securing the hardware, MSFC commissioned the Advanced Concepts Office to understand the capability and potential applications for the RS-34 Phoenix stage as it benefits NASA, DoD, and commercial industry. Originally designed, the RS-34 Phoenix provided in-space six-degrees-of freedom operational maneuvering to deploy multiple payloads at various orbital locations. The RS-34 Concept Study, preceded by a utilization study to understand how the unique capabilities of the RS-34 Phoenix and its application to six candidate missions, sought to further understand application for an orbital debris design reference mission as the orbital debris removal mission was found to closely mimic the heritage RS-34 mission. The RS-34 Orbital Debris Application Concept Study sought to identify multiple configurations varying the degree of modification to trade for dry mass optimization and propellant load for overall capability and evaluation of several candidate missions. The results of the RS-34 Phoenix Utilization Study show that the system is technically sufficient to successfully support all of the missions analyzed. The results and benefits of the RS-34 Orbital Debris Application Concept Study are presented in this paper.

Esther, Elizabeth A.; Burnside, Christopher G.

2013-01-01

271

LINGO1 rs9652490 is associated with Essential Tremor and Parkinson Disease  

PubMed Central

Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P=0.014) and Parkinson disease (P=0.0003), thus providing the first evidence of a genetic link between both diseases. PMID:19720553

Vilariño-Güell, Carles; Ross, Owen A.; Wider, Christian; Jasinska-Myga, Barbara; Cobb, Stephanie A.; Soto-Ortolaza, Alexandra I.; Kachergus, Jennifer M.; Keeling, Brett H.; Dachsel, Justus C.; Melrose, Heather L.; Behrouz, Bahareh; Wszolek, Zbigniew K.; Uitti, Ryan J.; Aasly, Jan O; Rajput, Alex; Farrer, Matthew J.

2010-01-01

272

Triggered Star Formation by Massive Stars  

NASA Astrophysics Data System (ADS)

We present our diagnosis of the role that massive stars play in the formation of low- and intermediate-mass stars in OB associations (the ? Ori region, Ori OB1, and Lac OB1 associations). We find that the classical T Tauri stars and Herbig Ae/Be stars tend to line up between luminous O stars and bright-rimmed or comet-shaped clouds; the closer to a cloud the progressively younger they are. Our positional and chronological study lends support to the validity of the radiation-driven implosion mechanism, where the Lyman continuum photons from a luminous O star create expanding ionization fronts to evaporate and compress nearby clouds into bright-rimmed or comet-shaped clouds. Implosive pressure then causes dense clumps to collapse, prompting the formation of low-mass stars on the cloud surface (i.e., the bright rim) and intermediate-mass stars somewhat deeper in the cloud. These stars are a signpost of current star formation; no young stars are seen leading the ionization fronts further into the cloud. Young stars in bright-rimmed or comet-shaped clouds are likely to have been formed by triggering, which would result in an age spread of several megayears between the member stars or star groups formed in the sequence.

Lee, Hsu-Tai; Chen, W. P.

2007-03-01

273

Triggered Star Formation by Massive Stars  

E-print Network

We present our diagnosis of the role that massive stars play in the formation of low- and intermediate-mass stars in OB associations (the Lambda Ori region, Ori OB1, and Lac OB1 associations). We find that the classical T Tauri stars and Herbig Ae/Be stars tend to line up between luminous O stars and bright-rimmed or comet-shaped clouds; the closer to a cloud the progressively younger they are. Our positional and chronological study lends support to the validity of the radiation-driven implosion mechanism, where the Lyman continuum photons from a luminous O star create expanding ionization fronts to evaporate and compress nearby clouds into bright-rimmed or comet-shaped clouds. Implosive pressure then causes dense clumps to collapse, prompting the formation of low-mass stars on the cloud surface (i.e., the bright rim) and intermediate-mass stars somewhat deeper in the cloud. These stars are a signpost of current star formation; no young stars are seen leading the ionization fronts further into the cloud. Young stars in bright-rimmed or comet-shaped clouds are likely to have been formed by triggering, which would result in an age spread of several megayears between the member stars or star groups formed in the sequence.

Hsu-Tai Lee; W. P. Chen

2009-02-03

274

Association of rs6265 and rs2030324 Polymorphisms in Brain-Derived Neurotrophic Factor Gene with Alzheimer’s Disease: A Meta-Analysis  

PubMed Central

Background The association between polymorphisms rs6265 and rs2030324 in brain-derived neurotrophic factor (BDNF) and Alzheimer’s disease (AD) has been widely reported, but the results remain controversial. Methods A comprehensive search of Pubmed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Med Online and China Biology Medical literature database (CBM) was performed. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models. We excluded the studies with OR>3.0 or OR<0.3 for sensitive analysis. Subgroup analysis by ethnicity, form of AD and gender was carried out. Meta-regression was conducted to explore the potential sources of between-study heterogeneity. Results 29 articles with 7548 cases and 7334 controls concerning rs6265 and 22 articles with 5796 cases and 5706 controls concerning rs2030324 were included in this meta-analysis. The combined evidence suggested rs6265 contributing significantly to the increased risk of AD in females (codominant: fixed-effects model (FEM): OR?=?1.13, 95% CI?=?1.04–1.23; dominant: FEM: OR?=?1.17, 95% CI?=?1.05–1.31), especially for Caucasian females (codominant: FEM: OR?=?1.18, 95% CI?=?1.03–1.34; dominant: FEM: OR?=?1.18, 95% CI?=?1.01–1.37) and female late-onset Alzheimer’s disease (LOAD) patients (codominant: FEM: OR?=?1.22, 95% CI?=?1.05–1.41; dominant: FEM: OR?=?1.23, 95% CI?=?1.03–1.46). No evidence indicated an association between rs2030324 with AD in codominant (random-effects model (REM): OR?=?1.06, 95% CI?=?0.89–1.26) and dominant (REM: OR?=?1.05, 95% CI?=?0.86–1.27) models. Conclusion This meta-analysis suggested A allele of rs6265 might increase the risk of AD in Caucasian females and female LOAD patients. In addition, no evidence indicated an association between rs2030324 with AD. Further studies are needed to confirm these results. PMID:24733169

Xie, Zhutian; Zhang, Dongfeng

2014-01-01

275

New insights into the dust formation of oxygen-rich AGB stars  

NASA Astrophysics Data System (ADS)

Context. Asymptotic giant branch (AGB) stars are one of the major sources of dust in the universe. The formation of molecules and dust grains and their subsequent expulsion into the interstellar medium via strong stellar winds is under intense investigation. This is in particular true for oxygen-rich stars, for which the path of dust formation has remained unclear. Aims: We conducted spatially and spectrally resolved mid-infrared multi-epoch interferometric observations to investigate the dust formation process in the extended atmospheres of oxygen-rich AGB stars. Methods: We observed the Mira variable AGB stars S Ori, GX Mon, and R Cnc between February 2006 and March 2009 with the MIDI instrument at the VLT interferometer. We compared the data to radiative transfer models of the dust shells, where the central stellar intensity profiles were described by dust-free dynamic model atmospheres. We used Al2O3 and warm silicate grains, following earlier studies in the literature. Results: Our S Ori and R Cnc data could be well described by an Al2O3 dust shell alone, and our GX Mon data by a mix of an Al2O3 and a silicate shell. The best-fit parameters for S Ori and R Cnc included photospheric angular diameters ?Phot of 9.7 ± 1.0 mas and 12.3 ± 1.0 mas, optical depths ?V(Al2O3) of 1.5 ± 0.5 and 1.35 ± 0.2, and inner radii Rin of 1.9 ± 0.3 RPhot and 2.2 ± 0.3 RPhot, respectively. Best-fit parameters for GX Mon were ?Phot = 8.7 ± 1.3 mas, ?V(Al2O3) = 1.9 ± 0.6, Rin(Al2O3) = 2.1 ± 0.3 RPhot, ?V(silicate)= 3.2 ± 0.5, and Rin(silicate)= 4.6 ± 0.2 RPhot. Our data did not show evidence of intra-cycle and cycle-to-cycle variability or of asymmetries within the error-bars and within the limits of our baseline and phase coverage. Conclusions: Our model fits constrain the chemical composition and the inner boundary radii of the dust shells, as well as the photospheric angular diameters. Our interferometric results are consistent with Al2O3 grains condensing close to the stellar surface at about 2 stellar radii, co-located with the extended atmosphere and SiO maser emission, and warm silicate grains at larger distances of about 4-5 stellar radii. We verified that the number densities of aluminum can match that of the best-fit Al2O3 dust shell near the inner dust radius in sufficiently extended atmospheres, confirming that Al2O3 grains can be seed particles for the further dust condensation. Together with literature data of the mass-loss rates, our sample is consistent with a hypothesis that stars with low mass-loss rates form primarily dust that preserves the spectral properties of Al2O3, and stars with higher mass-loss rate form dust with properties of warm silicates. Based on observations made with the Very Large Telescope Interferometer (VLTI) at the Paranal Observatory under program IDs 073.D-0711, 075.D-0097, 077.D-0630, 079.D-0172, and 082.D-0723.Tables 1-3, 8, 9 are available in electronic form at http://www.aanda.org

Karovicova, I.; Wittkowski, M.; Ohnaka, K.; Boboltz, D. A.; Fossat, E.; Scholz, M.

2013-12-01

276

Binary stars.  

PubMed

Most stars in the solar neighborhood are either double or multiple systems. They provide a unique opportunity to measure stellar masses and radii and to study many interesting and important phenomena. The best candidates for black holes are compact massive components of two x-ray binaries: Cygnus X-1 and LMC X-3. The binary radio pulsar PSR 1913 + 16 provides the best available evidence for gravitational radiation. Accretion disks and jets observed in close binaries offer a very good testing ground for models of active galactic nuclei and quasars. PMID:17749544

Paczynacuteski, B

1984-07-20

277

The threat of information theft by reception of electromagnetic radiation from RS232 cables  

Microsoft Academic Search

This report gives the results of theseexperiments and research into the underlyingmechanisms. These results show, that comparedwith the VDU case, RS-232 eavesdropping hassignificantly different consequences with regardto information security.

Peter Smulders

1990-01-01

278

Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation.  

PubMed

Herbert et al reported association with obesity of a common DNA variant rs7566605 at 10 kb upstream of the INSIG2 gene. We analyzed rs7566605 polymorphism in 3125 Chinese in a cross-sectional study. We found no significant association of rs7566605 polymorphism with body mass index (BMI) and waist circumference among all participants (P=0.52). However, if geographic location is considered, the C/C genotype of rs7566605 was marginally associated with increased levels of BMI and risk of obesity among individuals living in Shanghai (P=0.06), indicating that the C/C genotype may contribute to obesity in certain subpopulation among Chinese under certain environmental settings. PMID:18270535

Yang, Ling; Wu, Ying; Li, Huaixin; Yu, Zhijie; Li, Xin; Liu, Yong; Lin, Xu; Chen, Yan

2008-06-01

279

mu-XRF\\/mu-RS vs. SR mu-XRD for pigment identification in illuminated manuscripts  

Microsoft Academic Search

For the non-destructive identification of pigments and colorants in works of art, in archaeological and in forensic materials, a wide range of analytical techniques can be used. Bearing in mind that every method holds particular limitations, two complementary spectroscopic techniques, namely confocal mu-Raman spectroscopy (mu-RS) and mu-X-ray fluorescence spectroscopy (mu-XRF), were joined in one instrument. The combined mu-XRF and mu-RS

G. van der Snickt; W. de Nolf; B. Vekemans; K. Janssens

2008-01-01

280

?-XRF\\/?-RS vs. SR ?-XRD for pigment identification in illuminated manuscripts  

Microsoft Academic Search

For the non-destructive identification of pigments and colorants in works of art, in archaeological and in forensic materials,\\u000a a wide range of analytical techniques can be used. Bearing in mind that every method holds particular limitations, two complementary\\u000a spectroscopic techniques, namely confocal ?-Raman spectroscopy (?-RS) and ?-X-ray fluorescence spectroscopy (?-XRF), were\\u000a joined in one instrument. The combined ?-XRF and ?-RS

G. Van der Snickt; W. De Nolf; B. Vekemans; K. Janssens

2008-01-01

281

R+S^2 theories of gravity without big-bang singularity  

E-print Network

The R+S^2 theories of gravity with the matter fields described by a Weyssenhoff fluid are analyzed, where S^2 stands for the quadratic torsion terms. It is found that a subclass of the R+S^2 theories may solve the singularity problem of the homogenous and isotropic universe. Actually, it is shown that the torsion effect is either zero or equivalent to an additional ideal fluid with the energy density equal to the hydrostatic pressure.

Lu, Jia-An

2014-01-01

282

Utilization of Heavy Metal Molten Salts in the ARIES-RS Fusion Reactor  

Microsoft Academic Search

ARIES-RS is one of the major magnetic fusion energy reactor designs that uses a blanket having vanadium alloy structure cooled\\u000a by lithium [1, 2]. It is a deuterium–tritium (DT) fusion driven reactor, having a fusion power of 2170 MW [1, 2]. This study presents the neutronic analysis of the ARIES-RS fusion reactor using heavy metal molten salts in which Li2BeF4 as

Mustafa Übeyli; Hüseyin Yap?c?

2008-01-01

283

Effect of Tryptophan Hydroxylase2 rs7305115 SNP on suicide attempts risk in major depression  

Microsoft Academic Search

BACKGROUND: Suicide and major depressive disorders (MDD) are strongly associated, and genetic factors are responsible for at least part of the variability in suicide risk. We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene rs7305115 SNP may predispose to suicide attempts in MDD. METHODS: We genotyped TPH2 gene rs7305115 SNP in 215 MDD patients with suicide and matched MDD

Yuqi Zhang; Changsong Zhang; Guozhen Yuan; Jianjun Yao; Zaohuo Cheng; Chaojun Liu; Qinghai Liu; Gairong Wan; Guizhi Shi; Yiren Cheng; Yang Ling; Ke Li

2010-01-01

284

Wireless transmission of RS232 interface signal based on ZigBee  

Microsoft Academic Search

RS232 interfaces are widely used in data transmission, such as wireless meter reading, digital image transmission, industrial data collection, cell paging, fire-proof system, radio frequency identification card, local alarm system, and so on. Since the longest distance of cable transmission is only 15 meters, so it is important to develop a kind of RS232 interface used for wireless transmission. ZigBee

Guoxin Luo

2010-01-01

285

LINGO1 rs9652490 is associated with essential tremor and Parkinson disease  

Microsoft Academic Search

Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series

Carles Vilariño-Güell; Owen A. Ross; Christian Wider; Barbara Jasinska-Myga; Stephanie A. Cobb; Alexandra I. Soto-Ortolaza; Jennifer M. Kachergus; Brett H. Keeling; Justus C. Dachsel; Heather L. Melrose; Bahareh Behrouz; Zbigniew K. Wszolek; Ryan J. Uitti; Jan O. Aasly; Alex Rajput; Matthew J. Farrer

2010-01-01

286

Overview of the ARIES-RS reversed-shear tokamak power plant study  

Microsoft Academic Search

The ARIES-RS tokamak is a conceptual, D–T-burning 1000 MWe power plant. As with earlier ARIES design studies, the final design of ARIES-RS was obtained in a self-consistent manner using the best available physics and engineering models. Detailed analyses of individual systems together with system interfaces and interactions were incorporated into the ARIES systems code in order to assure self-consistency and

Farrokh Najmabadi; Charles G. Bathke; Michael C. Billone; James P. Blanchard; Leslie Bromberg; Edward Chin; Fredrick R. Cole; Jeffrey A. Crowell; David A. Ehst; Laila A. El-Guebaly; J. Stephen Herring; Thanh Q. Hua; Stephen C. Jardin; Charles E. Kessel; Hesham Khater; V. Dennis Lee; Siegfried Malang; Tak-Kuen Mau; Ronald L. Miller; Elsayed A. Mogahed; Thomas W. Petrie; Elmer E. Reis; Joel Schultz; M. Sidorov; Don Steiner; Igor N. Sviatoslavsky; Dai-Kai Sze; Robert Thayer; Mark S. Tillack; Peter Titus; Lester M. Wagner; Xueren Wang; Clement P. C. Wong

1997-01-01

287

Utilização dos laboratórios de informática em escolas municipais de Passo Fundo\\/RS1 Use of Computer Labs in Schools of Passo Fundo\\/RS  

Microsoft Academic Search

This paper is a report on the experience achieved in a research that has been accomplished in ten schools of the teaching municipal network of Passo Fundo\\/RS. The purpose of that research was to verify, in the educative process dynamics, which were the reflections on the network technology usage by teachers and students. Before the actual research could be carried

Karina Marcon; Adriano Canabarro Teixeira

288

Association of a redefined proximal mouse chromosome 11 imprinting region and U2afbp-rs/U2af1-rs1 expression.  

PubMed

Mice with maternal and paternal disomy for chromosome 11 (Chr 11) show growth retarded and overgrowth phenotypes, respectively, which can be attributed to genomic imprinting. Previous studies have defined the region of Chr 11 responsible (the Chr 11 imprinting region) as lying proximal to the T30H translocation breakpoint at the borders of G-bands 11B1.2 and 11B1.3. Evidence is presented here with two new translocations, T57H and T41Ad, which sequentially reduce the size of the imprinting region and locate it proximal to the T41Ad breakpoint in G-band 11A3.2. It therefore lies close to the centromere. The imprinted gene, U2af1-rs1, is known to be located within the original region and has been regarded as a candidate for the imprinting effects. Meiotic and mitotic chromosome FISH analysis, together with U2af1-rs1 expression studies are now described which show that the gene lies within the newly defined imprinting region and that its expression levels relate to the presence/absence and number of functional paternal alleles. U2af1-rs1 therefore remains a candidate gene for the Chr 11 imprinting effects. However, another recently reported imprinted gene, Meg1/Grb10, that lies within the region is also a good candidate, as it encodes a growth factor receptor. Meg1/Grb10 maps about 15 cM from U2af1-rs1 and is separated by conserved regions showing homology with two different human chromosomes. For these reasons, and because the two human homologues of U2af1-rs1 and Meg1/Grb10 also lie on different chromosomes, it would seem likely that the two genes identify two distinct imprinting domains within the small proximal region of mouse Chr 11. PMID:9678333

Cattanach, B M; Shibata, H; Hayashizaki, Y; Townsend, K M; Ball, S; Beechey, C V

1998-01-01

289

An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform  

PubMed Central

Background Although genome wide studies have associated single nucleotide polymorphisms (SNP)s near PICALM with Alzheimer’s disease (AD), the mechanism underlying this association is unclear. PICALM is involved in clathrin-mediated endocytosis and modulates Aß clearance in vitro. Comparing allelic expression provides the means to detect cis-acting regulatory polymorphisms. Thus, we evaluated whether PICALM showed allele expression imbalance (AEI) and whether this imbalance was associated with the AD-associated polymorphism, rs3851179. Results We measured PICALM allelic expression in 42 human brain samples by using next-generation sequencing. Overall, PICALM demonstrated equal allelic expression with no detectable influence by rs3851179. A single sample demonstrated robust global PICALM allelic expression imbalance (AEI), i.e., each of the measured isoforms showed AEI. Moreover, the PICALM isoform lacking exons 18 and 19 (D18-19 PICALM) showed significant AEI in a subset of individuals. Sequencing these individuals and subsequent genotyping revealed that rs588076, located in PICALM intron 17, was robustly associated with this imbalance in D18-19 PICALM allelic expression (p?=?9.54 x 10-5). This polymorphism has been associated previously with systolic blood pressure response to calcium channel blocking agents. To evaluate whether this polymorphism was associated with AD, we genotyped 3269 individuals and found that rs588076 was modestly associated with AD. However, when both the primary AD SNP rs3851179 was added to the logistic regression model, only rs3851179 was significantly associated with AD. Conclusions PICALM expression shows no evidence of AEI associated with rs3851179. Robust global AEI was detected in one sample, suggesting the existence of a rare SNP that strongly modulates PICALM expression. AEI was detected for the D18-19 PICALM isoform, and rs588076 was associated with this AEI pattern. Conditional on rs3851179, rs588076 was not associated with AD risk, suggesting that D18-19 PICALM is not critical in AD. In summary, this analysis of PICALM allelic expression provides novel insights into the genetics of PICALM expression and AD risk. PMID:25169757

2014-01-01

290

Star Search  

NSDL National Science Digital Library

In this online activity, learners can test their skills at finding constellations in the northern hemisphere's night sky. Learners can choose during which season to look, and then look for four constellations in that season. The simulation shows a simple representation of the night sky with key stars highlighted. Use this as a practice before going outside or just to give learners an idea of the difficulties involved in identifying constellations. When learners set up a free account at Kinetic City, they can answer bonus questions at the end of the activity as a quick assessment. As a larger assessment, learners can complete the Smart Attack game after they've completed several activities.

Science, American A.

2009-01-01

291

High spectral resolution observations of the coronal X-ray emission from the RS CVn binary Sigma Corona Borealis  

NASA Technical Reports Server (NTRS)

The results of high-resolution observations of the RS CVn binary star Rho Cr B are reported. The observations were carried out using the Focal Plane Crystal Spectrometer (FPCS) onboard the Einstein Observatory satellite. A spectral scan in the interval 800-840 eV shows clear evidence of an X-ray emission line at 826 eV identified with 1S(0)-1P(1) transition of Fe XVII. A prominent peak at 1007 eV in the scan band 986-1014 eV was attributed to a blend of lines produced by highly ionized iron. On the basis of the observed fluxes of the lines and the theoretical calculations of Raymond and Smith (1977), best-fit values of corona temperature and volume emission measures of 6.92 (+0.84 or -0.75) x 10 to the 6th K, and 1.74 (+0.55 or -0.69) x 10 to the 35th are derived, respectively. Some implications of the results are briefly discussed.

Agrawal, P. C.; Markert, T. H.; Riegler, G. R.

1985-01-01

292

O stars and Wolf-Rayet stars  

NASA Technical Reports Server (NTRS)

Basic information is given about O and Wolf-Rayet stars indicating how these stars are defined and what their chief observable properties are. Part 2 of the volume discussed four related themes pertaining to the hottest and most luminous stars. Presented are: an observational overview of the spectroscopic classification and extrinsic properties of O and Wolf-Rayet stars; the intrinsic parameters of luminosity, effective temperature, mass, and composition of the stars, and a discussion of their viability; stellar wind properties; and the related issues concerning the efforts of stellar radiation and wind on the immediate interstellar environment are presented.

Conti, Peter S.; Underhill, Anne B.; Jordan, Stuart (editor); Thomas, Richard (editor)

1988-01-01

293

RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist  

PubMed Central

Efforts to define precisely the role of 5-HT2B receptors in normal and disease processes have been hindered by the absence of selective antagonists. To address this deficiency, we developed a series of naphthylpyrimidines as potentially useful 5-HT2B receptor antagonists. RS-127445 (2-amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine) was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5±0.1) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. In cells expressing human recombinant 5-HT2B receptors, RS-127445 potently antagonized 5-HT-evoked formation of inositol phosphates (pKB=9.5±0.1) and 5-HT-evoked increases in intracellular calcium (pIC50=10.4±0.1). RS-127445 also blocked 5-HT-evoked contraction of rat isolated stomach fundus (pA2=9.5±1.1) and (±)?-methyl-5-HT-mediated relaxation of the rat jugular vein (pA2=9.9±0.3). RS-127445 had no detectable intrinsic activity in these assays. In rats, the fraction of RS-127445 that was bioavailable via the oral or intraperitoneal routes was 14 and 60% respectively. Intraperitoneal administration of RS-127445 (5?mg?kg?1) produced plasma concentrations predicted to fully saturate accessible 5-HT2B receptors for at least 4?h. In conclusion, RS-127445 is a selective, high affinity 5-HT2B receptor antagonist suitable for use in vivo. The therapeutic potential of this molecule is being further evaluated. PMID:10455251

Bonhaus, Douglas W; Flippin, Lee A; Greenhouse, Robert J; Jaime, Saul; Rocha, Cindy; Dawson, Mark; Van Natta, Kristine; Chang, L K; Pulido-Rios, Tess; Webber, Andrea; Leung, Edward; Eglen, Richard M; Martin, Graeme R

1999-01-01

294

The CYP7A1 gene rs3808607 variant is associated with susceptibility of tuberculosis in Moroccan population  

PubMed Central

Introduction Despite the medical progress in treatment. Tuberculosis (TB) continues to be a serious global health problem. A genome-wide linkage study identified a major susceptibility locus on chromosomal region 8q12-q13 in Moroccan TB patients. The CYP7A1 gene is located in this region and codes for cholesterol 7a-hydroxylase, an enzyme involved in cholesterol catabolism. Methods We selected three SNPs (rs3808607, rs8192875 and rs8192879) and studied their genotype and allele frequencies distribution in patients with pulmonary (PTB) or pleural TB (pTB), and compared them to Healthy Controls (HC). Genotyping of rs8192875 and rs8192879 SNPs was carried out using the Taq Man SNP genotyping Assay while rs3808607 was investigated by PCR-RFLP. Results We reported here for the first time a statistically significant increase in the AA homozygote genotype frequency of rs3808607 in PTB patients compared to HC (p = 0.02, OR = 1.93, 95% CI: 1.93 (1.07;3.49). The increased risk of developing TB was maintained when we combined the groups of patients (PTB-pTB) (p = 0.01, OR= 1.91, 95% CI = (1.07 - 3.42). In contrast, no genetic association was observed between the rs8192875 or rs8192879 polymorphisms and TB. Conclusion Our investigations suggest that rs3808607 may play a role in susceptibility to TB in a Moroccan population. PMID:25360185

Qrafli, Mounia; Amar, Youssef; Bourkadi, Jamaleddine; Ben Amor, Jouda; Iraki, Ghali; Bakri, Youssef; Amzazi, Saaîd; Lahlou, Ouafae; Seghrouchni, Fouad; El Aouad, Rajae; Sadki, Khalid

2014-01-01

295

Massive Stars in Transition  

E-print Network

We discuss the various post-main sequence phases of massive stars, focusing on Wolf-Rayet stars, Luminous Blue Variables, plus connections with other early-type and late-type supergiants. End states for massive stars are also investigated, emphasising connections between Supernovae originating from core-collapse massive stars and Gamma Ray Bursts.

Paul A. Crowther

2003-05-08

296

Lifestyles of the Stars.  

ERIC Educational Resources Information Center

Some general information on stars is provided in this National Aeronautics and Space Administration pamphlet. Topic areas briefly discussed are: (1) the birth of a star; (2) main sequence stars; (3) red giants; (4) white dwarfs; (5) neutron stars; (6) supernovae; (7) pulsars; and (8) black holes. (JN)

National Aeronautics and Space Administration, Cocoa Beach, FL. John F. Kennedy Space Center.

297

Counting Your Lucky Stars  

NSDL National Science Digital Library

In this activity, learners sample a star field to estimate the number of stars in the universe. This activity simulates how astronomers use sampling instead of census (counting) to more easily collect data in space. Learners predict, count, approximate, and average the number of stars in a Star Field Sheet.

Ricles, Shannon; Hatok, Tim; Taylor, Berlina

2013-01-30

298

Star Clusters Sterrenstelsels & Kosmos  

E-print Network

Star Clusters Sterrenstelsels & Kosmos deel 2 1 #12;Types of star clusters 2 #12;Open or Galactic Clusters · "Open" or Galactic clusters are low mass, relatively small (~10 pc diameter) clusters of stars in the Galactic disk containing stars · The Pleiades cluster is a good example of an open cluster

Weijgaert, Rien van de

299

Egyptian "Star Clocks"  

NASA Astrophysics Data System (ADS)

Diagonal, transit, and Ramesside star clocks are tables of astronomical information occasionally found in ancient Egyptian temples, tombs, and papyri. The tables represent the motions of selected stars (decans and hour stars) throughout the Egyptian civil year. Analysis of star clocks leads to greater understanding of ancient Egyptian constellations, ritual astronomical activities, observational practices, and pharaonic chronology.

Symons, Sarah

300

RS-34 Phoenix In-Space Propulsion System Applied to Active Debris Removal Mission  

NASA Technical Reports Server (NTRS)

In-space propulsion is a high percentage of the cost when considering Active Debris Removal mission. For this reason it is desired to research if existing designs with slight modification would meet mission requirements to aid in reducing cost of the overall mission. Such a system capable of rendezvous, close proximity operations, and de-orbit of Envisat class resident space objects has been identified in the existing RS-34 Phoenix. RS-34 propulsion system is a remaining asset from the de-commissioned United States Air Force Peacekeeper program; specifically the pressure-fed storable bi-propellant Stage IV Post Boost Propulsion System. The National Aeronautics and Space Administration (NASA) Marshall Space Flight Center (MSFC) gained experience with the RS-34 propulsion system on the successful Ares I-X flight test program flown in the Ares I-X Roll control system (RoCS). The heritage hardware proved extremely robust and reliable and sparked interest for further utilization on other potential in-space applications. Subsequently, MSFC has obtained permission from the USAF to obtain all the remaining RS-34 stages for re-use opportunities. The MSFC Advanced Concepts Office (ACO) was commissioned to lead a study for evaluation of the Rocketdyne produced RS-34 propulsion system as it applies to an active debris removal design reference mission for resident space object targets including Envisat. Originally designed, the RS-34 Phoenix provided in-space six-degrees-of freedom operational maneuvering to deploy payloads at multiple orbital locations. The RS-34 Concept Study lead by sought to further understand application for a similar orbital debris design reference mission to provide propulsive capability for rendezvous, close proximity operations to support the capture phase of the mission, and deorbit of single or multiple large class resident space objects. Multiple configurations varying the degree of modification were identified to trade for dry mass optimization and propellant load. The results of the RS-34 Phoenix Concept Study show that the system is technically sufficient to successfully support all of the missions to rendezvous, capture, and de-orbit targets including Envisat and Hubble Space Telescope. The results and benefits of the RS-34 Orbital Debris Application Concept Study are presented in this paper.

Esther, Elizabeth A.; Burnside, Christopher G.

2014-01-01

301

Prediction of solubilities for ginger bioactive compounds in hot water by the COSMO-RS method  

NASA Astrophysics Data System (ADS)

The solubilities in water of four main ginger bioactives, 6-gingerol, 6-shogaol, 8-gingerol and 10-gingerol, were predicted using a conductor-like screening model for real solvent (COSMO-RS) calculations. This study was conducted since no experimental data are available for ginger bioactive solubilities in hot water. The ?-profiles of these selected molecules were calculated using Gaussian software and the solubilities were calculated using the COSMO-RS method. The solubilities of these ginger bioactives were calculated at 50 to 200 °C. In order to validate the accuracy of the COSMO-RS method, the solubilities of five hydrocarbon molecules were calculated using the COSMO-RS method and compared with the experimental data in the literature. The selected hydrocarbon molecules were 3-pentanone, 1-hexanol, benzene, 3-methylphenol and 2-hydroxy-5-methylbenzaldehyde. The calculated results of the hydrocarbon molecules are in good agreement with the data in the literature. These results confirm that the solubilities of ginger bioactives can be predicted using the COSMO-RS method. The solubilities of the ginger bioactives are lower than 0.0001 at temperatures lower than 130 °C. At 130 to 200 °C, the solubilities increase dramatically with the highest being 6-shogaol, which is 0.00037 mole fraction, and the lowest is 10-gingerol, which is 0.000039 mole fraction at 200 °C.

Zaimah Syed Jaapar, Syaripah; Azian Morad, Noor; Iwai, Yoshio

2013-04-01

302

Structure and physical map of Rhodopseudomonas sphaeroides bacteriophage RS1 DNA.  

PubMed Central

We analyzed, by restriction endonuclease mapping and electron microscopy, the genome of the lytic Rhodopseudomonas sphaeroides-specific bacteriophage RS1 and characterized it as a linear molecule of approximately 60 to 65 kilobases. When the DNA from purified phage particles was examined by several independent methods, considerable size heterogeneity was apparent in the RS1 DNA. This size heterogeneity was concluded to be of biological origin, was independent of the specific host strain used to propagate virus, and was not due to the presence of host DNA within or nonspecifically associated with purified virions. In addition, treatment of RS1 DNA with either BAL 31 nuclease or DNA polymerase I Klenow fragment revealed that several distinct regions exist within the viral chromosome which contain free 3' hydroxyl groups. A restriction endonuclease map of the RS1 genome was constructed by using the restriction endonucleases EcoRI, ClaI, KpnI, BamHI, MluI, SmaI, and BclI; thereby allowing the positioning of some 40 restriction sites within the viral genome. The results are discussed in terms of the significance and the possible biological origin of the unique features discovered within the phage RS1 DNA. Images PMID:2989552

Donohue, T J; Chory, J; Goldsand, T E; Lynn, S P; Kaplan, S

1985-01-01

303

FIRE, A Test Bed for ARIES-RS/AT Advanced Physics and Plasma Technology  

SciTech Connect

The overall vision for FIRE [Fusion Ignition Research Experiment] is to develop and test the fusion plasma physics and plasma technologies needed to realize capabilities of the ARIES-RS/AT power plant designs. The mission of FIRE is to attain, explore, understand and optimize a fusion dominated plasma which would be satisfied by producing D-T [deuterium-tritium] fusion plasmas with nominal fusion gains {approx}10, self-driven currents of {approx}80%, fusion power {approx}150-300 MW, and pulse lengths up to 40 s. Achieving these goals will require the deployment of several key fusion technologies under conditions approaching those of ARIES-RS/AT. The FIRE plasma configuration with strong plasma shaping, a double null pumped divertor and all metal plasma-facing components is a 40% scale model of the ARIES-RS/AT plasma configuration. ''Steady-state'' advanced tokamak modes in FIRE with high beta, high bootstrap fraction, and 100% noninductive current drive are suitable for testing the physics of the ARIES-RS/A T operating modes. The development of techniques to handle power plant relevant exhaust power while maintaining low tritium inventory is a major objective for a burning plasma experiment. The FIRE high-confinement modes and AT-modes result in fusion power densities from 3-10 MWm{sup -3} and neutron wall loading from 2-4 MWm{sup -2} which are at the levels expected from the ARIES-RS/AT design studies.

Dale M. Meade

2004-10-21

304

Reinvestigation of microwave spectrum of dimethyl ether and rs structures of analogous molecules  

NASA Astrophysics Data System (ADS)

Microwave spectra of dimethyl ether and its sixteen isotopic species have been measured. For species with singlet spectra, a least-squares analysis of observed transition frequencies gave rotational and five quartic centrifugal distortion constants. For species with multiplet spectra due to the methyl internal rotation, a least-squares analysis of observed multiplet frequencies gave not only unperturbed rotational and five quartic centrifugal distortion constants but also the quantities related to the methyl internal rotation. The rs structures from (CH 3) 2O, CH 3OCD 3, and (CD 3) 2O species as the parent species, respectively, were compared with one another. The proposed rs structure has been established from all the species measured and was compared with the rs-like structure obtained by a diagnostic least-squares method and with the reported structure. The rs structure of the present molecule was compared with the reported structures of dimethyl sulfide and dimethyl silane in relation to the tilt phenomenon. The rs structure of dimethyl sulfide was revised based on the present comparison.

Niide, Yuzuru; Hayashi, Michiro

2003-07-01

305

Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O -methyl-L-tyrosine  

Microsoft Academic Search

The Methanococcus jannaschii tRNATyr\\/TyrRS pair has been engineered to incorporate unnatural amino acids into proteins in E. coli. To reveal the structural basis for the altered specificity of mutant TyrRS for O-methyl-L-tyrosine (OMeTyr), the crystal structures for the apo wild-type and mutant M. jannaschii TyrRS were determined at 2.66 and 3.0 Å, respectively, for comparison with the published structure of

Yan Zhang; Lei Wang; Peter G. Schultz; Ian A. Wilson

2005-01-01

306

Symbiotic stars and other H? emission-line stars towards the Galactic bulge  

NASA Astrophysics Data System (ADS)

Symbiotic stars are interacting binaries with the longest orbital periods, and their multicomponent structure makes them rich astrophysical laboratories. The accretion of a high-mass-loss-rate red giant wind on to a white dwarf (WD) makes them promising Type Ia supernova (SN Ia) progenitors. Systematic surveys for new Galactic symbiotic stars are critical to identify new promising SN Ia progenitors (e.g. RS Oph) and to better estimate the total population size to compare against SN Ia rates. Central to the latter objective is building a complete census of symbiotic stars towards the Galactic bulge. Here we report on the results of a systematic survey of H? emission-line stars covering 35 deg2. It is distinguished by the combination of deep optical spectroscopy and long-term light curves that improve the certainty of our classifications. A total of 20 bona fide symbiotic stars are found (13 S-types, 6 D-types and 1 D'-type), 35 per cent of which show the symbiotic specific Raman-scattered O VI emission bands, as well as 15 possible symbiotic stars that require further study (six S-types and nine D-types). Light curves show a diverse range of variability including stellar pulsations (semi-regular and Mira), orbital variations and slow changes due to dust. Orbital periods are determined for five S-types and Mira pulsation periods for three D-types. The most significant D-type found is H1-45 and its carbon Mira with a pulsation period of 408.6 d, corresponding to an estimated period-luminosity relation distance of ˜6.2 ± 1.4 kpc and MK = -8.06 ± 0.12 mag. If H1-45 belongs to the Galactic bulge, then it would be the first bona fide luminous carbon star to be identified in the Galactic bulge population. The lack of luminous carbon stars in the bulge is a longstanding unsolved problem. A possible explanation for H1-45 may be that the carbon enhancement was accreted from the progenitor of the WD companion. A wide variety of unusual emission-line stars were also identified. These include central stars of planetary nebulae (PNe) [one (WC10-11) Wolf-Rayet and five with high-density cores], two novae, two WN6 Wolf-Rayet stars, two possible Be stars, a B[e] star with a bipolar outflow, an ultracompact H II region and a dMe flare star. Dust obscuration events were found in two central stars of PNe, increasing the known cases to five, as well as one WN6 star. There is considerable scope to uncover several more symbiotic stars towards the bulge, many of which are currently misclassified as PNe, provided that deep spectroscopy is combined with optical and near-infrared light curves.

Miszalski, Brent; Miko?ajewska, Joanna; Udalski, Andrzej

2013-07-01

307

Neutron Stars and NuSTAR  

NASA Astrophysics Data System (ADS)

My thesis centers around the study of neutron stars, especially those in massive binary systems. To this end, it has two distinct components: the observational study of neutron stars in massive binaries with a goal of measuring neutron star masses and participation in NuSTAR, the first imaging hard X-ray mission, one that is extremely well suited to the study of massive binaries and compact objects in our Galaxy. The Nuclear Spectroscopic Telescope Array (NuSTAR) is a NASA Small Explorer mission that will carry the first focusing high energy X-ray telescope to orbit. NuSTAR has an order-of-magnitude better angular resolution and has two orders of magnitude higher sensitivity than any currently orbiting hard X-ray telescope. I worked to develop, calibrate, and test CdZnTe detectors for NuSTAR. I describe the CdZnTe detectors in comprehensive detail here - from readout procedures to data analysis. Detailed calibration of detectors is necessary for analyzing astrophysical source data obtained by the NuSTAR. I discuss the design and implementation of an automated setup for calibrating flight detectors, followed by calibration procedures and results. Neutron stars are an excellent probe of fundamental physics. The maximum mass of a neutron star can put stringent constraints on the equation of state of matter at extreme pressures and densities. From an astrophysical perspective, there are several open questions in our understanding of neutron stars. What are the birth masses of neutron stars? How do they change in binary evolution? Are there multiple mechanisms for the formation of neutron stars? Measuring masses of neutron stars helps answer these questions. Neutron stars in high-mass X-ray binaries have masses close to their birth mass, providing an opportunity to disentangle the role of "nature" and "nurture" in the observed mass distributions. In 2006, masses had been measured for only six such objects, but this small sample showed the greatest diversity in masses among all classes of neutron star binaries. Intrigued by this diversity - which points to diverse birth masses - we undertook a systematic survey to measure the masses of neutron stars in nine high-mass X-ray binaries. In this thesis, I present results from this ongoing project. While neutron stars formed the primary focus of my work, I also explored other topics in compact objects. Appendix A describes the discovery and complete characterization of a 1RXS J173006.4+033813, a polar cataclysmic variable. Appendix B describes the discovery of a diamond planet orbiting a millisecond pulsar, and our search for its optical counterpart.

Bhalerao, Varun

2012-05-01

308

Human Resources rs_msc83 Page 1 of 10 Date issued: 25-Jul-13 Recruit & Select  

E-print Network

Human Resources ­ rs_msc83 Page 1 of 10 Date issued: 25-Jul-13 Recruit & Select Human Resources the Previous/Next buttons to view the various job vacancies. #12;Human Resources ­ rs_msc83 Page 4 of 10 Date description here to open a PDF version of the full Position Description. #12;Human Resources ­ rs_msc83 Page 5

Hickman, Mark

309

No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition.  

PubMed

A promoter polymorphism in the serotonin transporter gene has been widely studied in neuropsychiatry. We genotyped the 5-HTTLPR/rs25531 triallelic polymorphism in 728 schizophrenia cases from the CATIE study and 724 control subjects. In a logistic regression with case/control status as dependent variable and 7 ancestry-informative principal components as covariates, the effect of 5-HTTLPR/rs25531 composite genotype was not significant (odds ratio = 1.008, 95% CI 0.868-1.172, P = 0.91). In cases only, 5-HTTLPR/rs25531 was not associated with neurocognition (summary neurocognitive index P = 0.21, working memory P = 0.32) or symptomatology (PANSS positive P = 0.67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons. PMID:20468059

Konneker, Thomas I; Crowley, James J; Quackenbush, Corey R; Keefe, Richard S E; Perkins, Diana O; Stroup, T Scott; Lieberman, Jeffrey A; van den Oord, Edwin; Sullivan, Patrick F

2010-07-01

310

Genetic Algorithm to Make Persistent Security and Quality of Image in Steganography from RS Analysis  

E-print Network

Retention of secrecy is one of the significant features during communication activity. Steganography is one of the popular methods to achieve secret communication between sender and receiver by hiding message in any form of cover media such as an audio, video, text, images etc. Least significant bit encoding is the simplest encoding method used by many steganography programs to hide secret message in 24bit, 8bit colour images and grayscale images. Steganalysis is a method of detecting secret message hidden in a cover media using steganography. RS steganalysis is one of the most reliable steganalysis which performs statistical analysis of the pixels to successfully detect the hidden message in an image. However, existing steganography method protects the information against RS steganalysis in grey scale images. This paper presents a steganography method using genetic algorithm to protect against the RS attack in colour images. Stego image is divided into number of blocks. Subsequently, with the implementation ...

Nair, T R Gopalakrishnan; S, Manas

2012-01-01

311

Prognostic impact of the TP53 rs1625895 polymorphism in DLBCL patients.  

PubMed

This study aimed to clarify the association between the TP53 rs1625895 polymorphism and the efficiency of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) therapy in 106 patients with diffuse large B cell lymphoma (DLBCL). All patients received six to eight courses of R-CHOP therapy as a first-line treatment. The rs1625895 polymorphism was genotyped by polymerase chain reaction with restriction fragment length polymorphism assay. The G/G genotype of the TP53 rs1625895 polymorphism was shown to be associated with a high probability of R-CHOP therapy failure in DLBCL patients according to the probability of remission as well as 5-year overall and relapse-free survivals. PMID:25430047

Voropaeva, Elena N; Voevoda, Mikhail I; Pospelova, Tatiana I; Maksimov, Vladimir N

2014-11-28

312

P-bRS: A Physarum-Based Routing Scheme for Wireless Sensor Networks  

PubMed Central

Routing in wireless sensor networks (WSNs) is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH). Based on this model, we present a novel Physarum-based routing scheme (P-bRS) for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms. PMID:24672326

Wei, Wangyang; Zheng, Ruijuan; Wu, Qingtao

2014-01-01

313

An Xp22.1-p22.2 YAC contig encompassing the disease loci for RS, KFSD, CLS, HYP and RP15: refined localization of RS.  

PubMed

To facilitate the positional cloning of the genes involved in retinoschisis (RS), keratosis follicularis spinulosa decalvans (KFSD), Coffin-Lowry syndrome (CLS), X-linked hypophosphatemic rickets (XLH, locus name HYP) and X-linked dominant cone-rod degeneration (locus name RP15), we have extended the molecular map of the Xp22 region. Screening of several YAC libraries allowed us to identify 156 YACs, 52 of which localize between markers DXS414 (P90) and DXS451 (kQST80H1). Analysis of their marker content facilitated the construction of a YAC contig from the region spanning (in this order): DXS414 - DXS987 - DXS207 - DXS1053 - DXS197 - DXS 43 - DXS1195 - DXS418 - DXS999 - PDHA1 - DXS7161 - DXS443 - DXS 7592 - DXS1229 - DXS365 - DXS7101 - DXS7593 - DXS1052 - DXS274 - DXS989 - DXS451. The region between DXS414 and DXS451 covers about 4.5-5 Mb. Two additional markers (DXS7593 and DXS7592) were placed in the region, thereby increasing the genetic resolution. Using the deduced marker order, the analysis of key recombinants in families segregating RS allowed us to refine the critical region for RS to 0.6 Mb, between DXS418 and DXS7161. PMID:8744027

Van de Vosse, E; Bergen, A A; Meershoek, E J; Oosterwijk, J C; Gregory, S; Bakker, B; Weissenbach, J; Coffey, A J; van Ommen, G J; Den Dunnen, J T

1996-01-01

314

rs929387 of GLI3 Is Involved in Tooth Agenesis in Chinese Han Population  

PubMed Central

Tooth agenesis is one of the most common anomalies of human dentition. Recent studies suggest that a number of genes are related to both syndromic and non-syndromic forms of hypodontia. In a previous study, we observed that polymorphism in rs929387 of GLI3 might be associated with hypodontia in the Chinese Han population based on a limited population. To further confirm this observation, in this study, we employed 89 individuals diagnosed with sporadic non-syndromic oligodontia (40 males and 49 females) to investigate the relationship between polymorphism in rs929387 of GLI3 and tooth agenesis. These individuals were analyzed with 273 subjects (125 males and 148 females) diagnosed with non-syndromic hypodontia and 200 healthy control subjects (100 males and 100 females). DNA was obtained from whole blood or saliva samples and genotyping was performed by a Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) method. Significant differences were observed in the allele and genotype frequencies of rs929387 of GLI3. Distributions of genotypes TT, TC and CC of rs929387 polymorphism were significantly different between the case group and the control group (P = 0.013) and C allelic frequency was higher in case group [P = 0.002, OR = 1.690, 95% CI (1.200-2.379)]. Additionally, our analysis shows that this difference is more pronounced when compared between the male case group and the male control group. The function study suggests that variation in GLI3 caused by rs929387 leads to a decrease in its transcriptional activity. These data demonstrated an association between rs929387 of GLI3 and non-syndromic tooth agenesis in Chinese Han individuals. This information may provide further understanding of the molecular mechanisms of tooth agenesis. Furthermore, GLI3 can be regarded as a marker gene for the risk of tooth agenesis. PMID:24278334

Wong, Singwai; Nan, Xu; Zhao, Hongshan; Feng, Hailan

2013-01-01

315

RS-45041-190: a selective, high-affinity ligand for I2 imidazoline receptors.  

PubMed Central

1. RS-45041-190 (4-chloro-2-(imidazolin-2-yl)isoindoline) showed high affinity for I2 imidazoline receptors labelled by [3H]-idazoxan in rat (pKi = 8.66 +/- 0.09), rabbit (pKi = 9.37 +/- 0.07), dog (pKi = 9.32 +/- 0.18) and baboon kidney (pKi = 8.85 +/- 0.12), but had very low affinity for alpha 2-adrenoceptors in rat cerebral cortex (pKi = 5.7 +/- 0.09). 2. RS-45041-190 showed low affinity for other adrenoceptors, dopamine, 5-hydroxytryptamine, and muscarinic receptors and dihydropyridine binding sites (selectivity ratio > 1000). 3. RS-45041-190 showed moderate potency for the inhibition of monoamine oxidase A in vitro (pIC50 = 6.12), but had much lower potency for monoamine oxidase B (pIC50 = 4.47), neither of which equated with its affinity for I2 receptors. 4. RS-45041-190 (0.001 to 3 mg kg-1, i.v. and 1 ng-50 micrograms i.c.v.) had only small, transient effects on blood pressure and heart rate in anaesthetized rats. In conscious rats, RS-45041-190 had no effect on body core temperature or tail skin temperature (1 mg kg-1, s.c.) or on activity or rotarod performance (10 mg kg-1, i.p.). There were also no effects on barbiturate sleeping time in mice after doses of 1-10 mg kg-1, i.p. 5. RS-45041-190 (10 and 25 mg kg-1, i.p.) significantly increased food consumption in rats for up to 4 h after dosing, but unlike idazoxan (10 mg kg-1, i.p.) did not increase water consumption.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8528553

Brown, C. M.; MacKinnon, A. C.; Redfern, W. S.; Williams, A.; Linton, C.; Stewart, M.; Clague, R. U.; Clark, R.; Spedding, M.

1995-01-01

316

Quantitative assessment of the association between MTHFR rs1801131 polymorphism and risk of liver cancer.  

PubMed

Methylenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate metabolism which plays a key role in cell metabolism. MTHFR rs1801131 (A1298C) polymorphism can decrease in vitro MTHFR enzyme activity and has been hypothesized to be associated with liver cancer risk. This study aimed to quantify the strength of the association between MTHFR rs1801131 polymorphism and liver cancer risk by performing a meta-analysis. We searched the PubMed and Wanfang databases for studies relating on the association between MTHFR rs1801131 polymorphism and risk of liver cancer. Seven studies with 2,030 cases of liver cancer and 3,096 controls were finally included into the meta-analysis. Meta-analysis of a total of seven studies showed that the homozygote genotype CC of MTHFR rs1801131 polymorphism was significantly associated with decreased risk of liver cancer (for CC versus AA: odds ratio (OR)?=?0.65, 95% confidence interval (CI) 0.47-0.89, P?=?0.007; for CC versus AA?+?AC: OR?=?0.65, 95% CI 0.48-0.89, P?=?0.006). Subgroup by race showed that the homozygote genotype CC of MTHFR rs1801131 polymorphism was significantly associated with decreased risk of liver cancer in Asians (CC versus AA: OR?=?0.64, 95% CI 0.46-0.90, P?=?0.010; for CC versus AA?+ AC: OR?=?0.63, 95% CI 0.45-0.88, P?=?0.007). However, the association in Caucasians was still unclear owing to the limited data available now. Thus, Asian individuals with the homozygote genotype CC of MTHFR rs1801131 polymorphism are significantly associated with decreased risk of liver cancer. The association in Caucasians needs further studies. PMID:24014085

Liang, Tie-Jun; Liu, Hui; Zhao, Xiao-Qian; Tan, Yan-Rong; Jing, Kai; Qin, Cheng-Yong

2014-01-01

317

Characterization of novel RS1 exonic deletions in juvenile X-linked retinoschisis  

PubMed Central

Purpose X-linked juvenile retinoschisis (XLRS) is a vitreoretinal dystrophy characterized by schisis (splitting) of the inner layers of the neuroretina. Mutations within the retinoschisis (RS1) gene are responsible for this disease. The mutation spectrum consists of amino acid substitutions, splice site variations, small indels, and larger genomic deletions. Clinically, genomic deletions are rarely reported. Here, we characterize two novel full exonic deletions: one encompassing exon 1 and the other spanning exons 4–5 of the RS1 gene. We also report the clinical findings in these patients with XLRS with two different exonic deletions. Methods Unrelated XLRS men and boys and their mothers (if available) were enrolled for molecular genetics evaluation. The patients also underwent ophthalmologic examination and in some cases electroretinogram (ERG) recording. All the exons and the flanking intronic regions of the RS1 gene were analyzed with direct sequencing. Two patients with exonic deletions were further evaluated with array comparative genomic hybridization to define the scope of the genomic aberrations. After the deleted genomic region was identified, primer walking followed by direct sequencing was used to determine the exact breakpoints. Results Two novel exonic deletions of the RS1 gene were identified: one including exon 1 and the other spanning exons 4 and 5. The exon 1 deletion extends from the 5? region of the RS1 gene (including the promoter) through intron 1 (c.(?35)-1723_c.51+2664del4472). The exon 4–5 deletion spans introns 3 to intron 5 (c.185–1020_c.522+1844del5764). Conclusions Here we report two novel exonic deletions within the RS1 gene locus. We have also described the clinical presentations and hypothesized the genomic mechanisms underlying these schisis phenotypes. PMID:24227916

D’Souza, Leera; Cukras, Catherine; Antolik, Christian; Craig, Candice; He, Hong; Li, Shibo; Hejtmancik, James F.; Sieving, Paul A.; Wang, Xinjing

2013-01-01

318

Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia  

PubMed Central

Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene (VRK2), in multiple Asian and European samples. However, its effect on the brain structure in schizophrenia is little known. We analyzed the brain structure of 36 schizophrenia patients and 18 healthy subjects with regard to rs2312147 genotype groups. Brain magnetic resonance scans for gray matter (GM) and white matter (WM) analysis, and genotype analysis for VRK2 rs2312147, were conducted. The Positive and Negative Syndrome Scale and the Digit Symbol Test were assessed for schizophrenia patients. There was no significant difference in either GM volume or WM connectivity with regard to rs2312147 genotype in healthy subjects. In contrast, we found significant differences in the WM connectivity between rs2312147 CC and CT/TT genotype groups of schizophrenia patients. The related brain areas included the splenium of corpus callosum, the left occipital lobe WM, the internal capsule (left anterior limb and right retrolenticular part), the bilateral temporal lobe WM, the left fornix/stria terminalis, the left cingulate gyrus WM, and the left parietal lobe WM. Voxelwise correlation analysis revealed that the Digit Symbol Test scores (age corrected) correlated with the fractional anisotropy in WM tracts that previously showed significant group differences between the CT/TT and CC genotypes in the rs2312147 CT/TT genotype group, while no significant correlation was found in the CC genotype group. Our data may provide evidence for the effect of VRK2 on WM connectivity in patients with schizophrenia. PMID:25079070

Kim, Keun Hyang; Kim, Min-Kyoung; Choi, Tai Kiu; Lee, Sang-Hyuk

2014-01-01

319

PCSK1 rs6232 Is Associated with Childhood and Adult Class III Obesity in the Mexican Population  

PubMed Central

Background Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity in European populations. We aimed to evaluate the contribution of these variants to obesity and related traits in Mexican children and adults. Methodology/Principal Findings Rs6232 and rs6235 were genotyped in 2382 individuals, 1206 children and 1176 adults. Minor allele frequencies were 0.78% for rs6232 and 19.99% for rs6235. Rs6232 was significantly associated with childhood obesity and adult class III obesity (OR?=?3.01 95%CI 1.64–5.53; P?=?4×10?4 in the combined analysis). In addition, this SNP was significantly associated with lower fasting glucose levels (P?=?0.01) and with increased insulin levels and HOMA-B (P?=?0.05 and 0.01, respectively) only in non-obese children. In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group. Conclusion/Significance Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity. PMID:22737226

Villalobos-Comparán, Marisela; Villamil-Ramírez, Hugo; Villarreal-Molina, Teresa; Larrieta-Carrasco, Elena; León-Mimila, Paola; Romero-Hidalgo, Sandra; Jacobo-Albavera, Leonor; Liceaga-Fuentes, Adriana E.; Campos-Pérez, Francisco J.; López-Contreras, Blanca E.; Tusié-Luna, Teresa; del Río-Navarro, Blanca E.; Aguilar-Salinas, Carlos A.; Canizales-Quinteros, Samuel

2012-01-01

320

Long-term behaviour of starspots. III - Active longitudes on the long-period RS CVn star HK Lacertae  

NASA Technical Reports Server (NTRS)

Thirteen years of photometry were used to study active longitudes on the surface of HK Lacertae. The decaying and forming phenomena of active areas in the years of 1980-1981, 1983-1984, and 1988-1989 are shown. New activity centers suddenly occur near the same orbital phase (0.6) and have lifetimes of several (greater than 6) years. The average rotational period of HK Lac is 24.2852 d; compared to the orbital period of 24.4284 d, this implies a 32 degree/year drift of the active areas on the stellar surface. Two possible interpretations for the period difference are discussed: pseudosynchronism and rigidity of magnetic patterns. The active longitudes on HK Lac are compared with similar phenomena found on the sun.

Olah, K.; Hall, D. S.; Henry, G. W.

1991-01-01

321

A light-curve distortion-wave analysis of eight RS Canum Venaticorum systems  

NASA Astrophysics Data System (ADS)

A program of differential U,B,V photometry of 14 RS CVn systems carried out at Rosemary Hill Observatory in 1978 - 1981 is described, and an analysis of the light curves for the characteristic distortion wave for eight of the systems is presented. The V light curves of the systems are shown. Significant waves were observed in RS CVn, RZ Eri, and RW UMa. No significant waves were found in UX Com, GK Hya, AR Lac, LX Per, or TY Pyx. Unusual light curve distortions were observed in UX Com and AR Lac.

Caton, D. B.

1986-01-01

322

R+S^2 theories of gravity without big-bang singularity  

E-print Network

The R+S^2 theories of gravity, where S^2 denotes the quadratic torsion terms, are analyzed under three cases. In the first two cases, the matter fields are described by two different spin fluids which are not homogeneous and isotropic. In the third case, a homogeneous and isotropic torsion field is used. It is found that under all the three cases, the R+S^2 theories may avert the big-bang singularity of the Robertson--Walker universe, with three corresponding constraints on the parameters.

Jia-An Lu

2015-02-10

323

Accurate Alpha Abundance and C/O of Low-mass Stars  

NASA Astrophysics Data System (ADS)

We investigate methods for measuring elemental abundances in M dwarf stars from high resolution (R>25,000), near-infrared spectra. With synthetic spectra from the BT-Settl model atmosphere library, we identify NIR features sensitive to enhancement of alpha elements (C, O, Mg, Si, S, Ca, and Ti) in M dwarfs. We also describe a method for measuring the amount of oxygen not bound in CO from molecular and atomic features in the NIR Y-band that, when combined with recently published methods of measuring carbon abundance in M dwarfs from K-band spectra, provides the ratio of carbon to oxygen (C/O). The ratio of carbon to oxygen is an important parameter for determining interior structures of exoplanets and processes that drive planet formation as evidenced by recent studies of the super Earth 55 Cnc e. We outline a potential observing program to empirically calibrate these methods via a sample of M dwarfs with widely-separated (5''-1500''), but associated, F, G or K-type binary companions. Once calibrated, we will apply these methods to a survey of nearby M dwarfs, including many stars that will be observed by NASA's Transiting Exoplanet Survey Satellite (TESS).

Veyette, Mark; Muirhead, Philip; Mann, Andrew

2015-01-01

324

The Effects of Close-in Exoplanets on Their Host Stars  

NASA Astrophysics Data System (ADS)

In analogy to the RS CVn stars, it is expected that close-in planets can induce stellar activity due to tidal and magnetic interaction between the star and the planet. The tidal and/or magnetic interaction between the star and the planet is expected to affect the magnetic field of the star which then cause structural changes of the stellar wind, the corona, the chromosphere, and also spots on the stellar surface. Observations of these effects are difficult and have led to mixed results that can at least partly be explained by the transient nature of the phenomena. The detection of induced activity has been claimed for a number of stars hosting close-in planets. However the most extreme object, WASP-18, does not show any such signs. The active regions, which have been claimed as being caused by induced activity are not located at the sub-planetary point but often 70° - 80° ahead of it. Some studies have claimed that stars with close-in, massive exoplanets are statistically more active, but others conclude that this correlation is just the product of a selection bias. Studies with the Kepler-satellite show that superflares exist, but they do not seem to be caused by the interaction between stars and planets. While it is still discussed whether induced activity has been detected for planet-hosting main-sequence stars, the engulfment of planets when the star evolves to a giant might have dramatic consequences.

Guenther, Eike W.; Geier, Stephan

325

Retrospective Analysis of Antigen Prevalences of Renibacterium salmoninarum (Rs) Detected by Enzyme-Linked Immunosorbent Assay in Alaskan Pacific Salmon and Trout from 1988 to 2000 and Management of Rs in Hatchery Chinook and Coho Salmon  

Microsoft Academic Search

Five species of anadromous Pacific salmon Oncorhynchus spp. and eight species of nonanadromous fish, including trouts Oncorhynchus and Salvelinus spp., Arctic char S. alpinus, and Arctic grayling Thymallus arcticus (collectively called “trout”), from Alaskan waters were examined by enzyme-linked immunosorbent assay for annual and total prevalences of Renibacterium salmoninarum (Rs) from 1988 to 2000. The total prevalence of Rs antigen

T. R. Meyers; D. Korn; K. Glass; T. Burton; S. Short; K. Lipson; N. Starkey

2003-01-01

326

Star Formation in Galaxies  

NASA Technical Reports Server (NTRS)

Topics addressed include: star formation; galactic infrared emission; molecular clouds; OB star luminosity; dust grains; IRAS observations; galactic disks; stellar formation in Magellanic clouds; irregular galaxies; spiral galaxies; starbursts; morphology of galactic centers; and far-infrared observations.

1987-01-01

327

Astronomy: A Star Party  

NSDL National Science Digital Library

This lesson is designed to teach students about the functions of a telescope, the daylight uses of a telescope, the parts of the telescope, and to identify and view certain stars and planets during a star party at night.

328

Astrophysics: Stars fight back  

NASA Astrophysics Data System (ADS)

Galaxies contain fewer stars than predicted. The discovery of a massive galactic outflow of molecular gas in a compact galaxy, which forms stars 100 times faster than the Milky Way, may help to explain why. See Letter p.68

Hopkins, Philip F.

2014-12-01

329

Stars in Nutrition & Cancer  

Cancer.gov

Stars in Nutrition & Cancer Soy and Cancer: Wish You Were Young Again Star Speaker Stephen Barnes, PhD Professor, Department of Pharmacology and Toxicology University of Alabama Birmingham Birmingham, Alabama Meeting Date Monday, October 04, 2010

330

Remote Sens. 2013, 5, 5969-5998; doi:10.3390/rs5115969 Remote Sensing  

E-print Network

Remote Sens. 2013, 5, 5969-5998; doi:10.3390/rs5115969 Remote Sensing ISSN 2072-4292 www.mdpi.com/journal/remotesensing Article Simulating Land Cover Changes and Their Impacts on Land Surface Temperature in Dhaka, Bangladesh, little is known, to-date, about land cover dynamics and their impacts on land surface temperature (LST

Crawford, Ian

331

Remote Sens. 2011, 3, 708-720; doi:10.3390/rs3040708 Remote Sensing  

E-print Network

Remote Sens. 2011, 3, 708-720; doi:10.3390/rs3040708 Remote Sensing ISSN 2072-4292 www 2011 Abstract: The Ice, Cloud and Land Elevation Satellite (ICESat) laser altimetry mission from 2003 corresponding to water footprints across the transition from the land to water were analyzed. Water elevations

Paris-Sud XI, Université de

332

Remote Sens. 2014, 6, 10716-10732; doi:10.3390/rs61110716 remote sensing  

E-print Network

Remote Sens. 2014, 6, 10716-10732; doi:10.3390/rs61110716 remote sensing ISSN 2072-4292 www organization, which is indicative of a forest's ecological function. Here, this remote sensing technology in less structural variation between slope and non-sloped land and yielding taller, OPEN ACCESS #12;Remote

Weishampel, John F.

333

Early 3 Rs: How To Lead Beginners into Reading, Writing, and Arithme-TALK.  

ERIC Educational Resources Information Center

Directed to teachers, paraprofessionals, parents, and others interested in giving a young child an early start on the 3 Rs, this book provides easy-to-follow instructions for promoting emergent literacy and for teaching reading, writing, and arithmetic from preschool into the primary grades. The progression of content extends from early…

Mountain, Lee

334

Overview of ARIES-RS neutronics and radiation shielding: key issues and main conclusions  

Microsoft Academic Search

The neutronics and radiation shielding issues were assessed for the ARIES-RS power plant. The assessment addresses the breeding level, service lifetime, radiation damage, shielding requirements and design, and personnel protection. Major efforts were devoted to fulfil the top-level requirements which include the demonstration of a closed tritium fuel cycle, generation of no radioactive waste greater than Class C, and production

L. A. El-Guebaly

1997-01-01

335

Measuring Resilience With the RS-14: A Tale of Two Samples.  

PubMed

The purpose of this study was to systematically examine the psychometric properties of the 14-item Resilience Scale (RS-14; Wagnild, 2009a). Exploratory and confirmatory factor-analytic methods were employed, including an analysis of measurement invariance models by sex and race/ethnicity. Descriptive statistics, reliability, and validity data were also calculated. Analyses were based on 2 samples, one made up of individuals seeking mental health services following the 2010 Gulf oil spill (N = 1,032) and the other made up of university students (N = 1,765). For both samples, all items loaded (>.30) onto 1 factor, indicating cohesive structure for a 1-factor model explaining 53.2% of the variance in the clinical sample and 67.6% of the variance in the undergraduate sample. Further, the examination of measurement invariance indicated that the RS-14 was similarly structured for sex and race/ethnicity. Reliability coefficients exceeded .90 for both samples and also when data were examined by comparison groups. The RS-14 correlated significantly and as expected with measures of positive concepts (such as perceived meaning in life and satisfaction with life) and indexes of psychological distress (such as depression, anxiety, stress, and posttraumatic stress). These data support the utility of the RS-14 with clinical and undergraduate student samples. Implications for these data are discussed. PMID:25257682

Aiena, Bethany J; Baczwaski, Brandy J; Schulenberg, Stefan E; Buchanan, Erin M

2014-09-25

336

Fusion Engineering and Design 38 (1997) 115137 ARIES-RS divertor system selection and analysis  

E-print Network

by the control of impurities and helium ash removal. For the ARIES-RS design, a double- null divertor configuration creates a practical means to enhance ash removal and pumping while focusing the flow of power. Migration of power from the core through the plasma mantle and the scrape-off layer (SOL

337

Temperaturas de armazenamento de alimentos em estabelecimentos comerciais na cidade de Santa Maria, RS  

Microsoft Academic Search

The correct temperature of storage is very important for food conservation, which is essential for the prevention of foodborne diseases. The present study aimed to evaluate the range in temperature in storage equipment used in grocery and food stores in Santa Maria, RS\\/Brazil. The evaluation was an observation-descriptive study during the period from April to October 2003. The temperature of

Lisandra Mürmann; Carlos Augusto Mallmann; Paulo Dilkin

338

Different frequency of epidermal growth factor rs76189946 polymorphism genotype in an Iranian colorectal cancer  

PubMed Central

Aim This study aimed to determinant association between rs76189946 polymorphism of EGF gene and risk of colorectal cancer in an Iranian population. Background Colorectal cancer (CRC) is the third most prevalent cancer in both genders worldwide. The determination of genetic variation becomes a new way to etiology of colorectal cancer. Epidermal growth factor (EGF) is a mitogen that plays an important role in cell growth and tumourigenesis, this protein acts by binding its receptor, EGFR. Patients and methods DNA samples taken from totally 125 CRC patients and healthy controls were amplified by polymerase chain reaction (PCR) for the rs76189946 polymorphism. Genotypes were analyzed using restriction fragment length polymorphism (RFLP). Finally to confirm the RFLP procedure, 20 of the PCR products were sequenced using the ABI PRISM 3130xl Genetic Analyzer and chain termination method (Applied Biosystems, Carlsbad, CA). Results Genotype distribution and allele frequency was similar in CRC patients and controls individuals. We expect observe C and G allele in both groups but only was found C allele. Conclusion In this study for first time we identified genetic distribution of exonic rs76189946 polymorphism in EGF gene both CRC patients and healthy controls. These results suggest there wasn't association between EGF polymorphism rs76189946 and risk of colorectal cancer in an Iranian population. PMID:24834285

Chaleshi, Vahid; Savabkar, Sanaz; Dolatmoradi, Hesamodin; Haghighi, Mahdi Montazer; Maryan, Elmira Khalili; Pasha, Sara; Vandfaez, Narges Ebrahimi; Mojarad, Ehsan Nazemalhosseini; Zali, Mohammad Reza

2013-01-01

339

The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes  

PubMed Central

Therapeutic interventions in prediabetes are important in the primary prevention of type 2 diabetes (T2D) and its chronic complications. However, little is known about the pharmacogenetic effect of traditional herbs on prediabetes treatment. A total of 194 impaired glucose tolerance (IGT) subjects were treated with traditional hypoglycemic herbs (Tianqi Jiangtang) for 12 months in this study. DNA samples were genotyped for 184 mutations in 34 genes involved in drug metabolism or transportation. Multinomial logistic regression analysis indicated that rs1142345 (A > G) in the thiopurine S-methyltransferase (TPMT) gene was significantly associated with the hypoglycemic effect of the drug (P = 0.001, FDR P = 0.043). The “G” allele frequencies of rs1142345 in the healthy (subjects reverted from IGT to normal glucose tolerance), maintenance (subjects still had IGT), and deterioration (subjects progressed from IGT to T2D) groups were 0.094, 0.214, and 0.542, respectively. Binary logistic regression analysis indicated that rs1142345 was also significantly associated with the hypoglycemic effect of the drug between the healthy and maintenance groups (P = 0.027, OR = 4.828) and between the healthy and deterioration groups (P = 0.001, OR = 7.811). Therefore, rs1142345 was associated with the clinical effect of traditional hypoglycemic herbs. Results also suggested that TPMT was probably involved in the pharmacological mechanisms of T2D. PMID:23737827

Li, Xi; Lian, Feng-Mei; Guo, Dong; Fan, Lan; Tang, Jie; Peng, Jing-Bo; Deng, Hong-Wen; Liu, Zhao-Qian; Xiao, Xin-Hua; Wang, Yan-Rong; Qu, Ke-Yi; Deng, Sheng; Zhong, Qi; Sha, Yi-Ling; Zhu, Yan; Bai, Yu-Jing; Chen, Xin-Yan; Zhou, Qiang; Zhou, Hong-Hao; Tong, Xiao-Lin; Zhang, Wei

2013-01-01

340

A fast technique for computing syndromes of BCH and RS codes. [deep space network  

NASA Technical Reports Server (NTRS)

A combination of the Chinese Remainder Theorem and Winograd's algorithm is used to compute transforms of odd length over GF(2 to the m power). Such transforms are used to compute the syndromes needed for decoding CBH and RS codes. The present scheme requires substantially fewer multiplications and additions than the conventional method of computing the syndromes directly.

Reed, I. S.; Truong, T. K.; Miller, R. L.

1979-01-01

341

Design of vancomycin RS-100 nanoparticles in order to increase the intestinal permeability  

PubMed Central

Purpose: The purpose of this work was to preparation of vancomycin (VCM) biodegradable nanoparticles to improve the intestinal permeability, using water-in-oil-in-water (W/O/W) multiple emulsion method. Methods: The vancomycin-loaded nanoparticles were created using double-emulsion solvent evaporation method. Using Eudragit RS100 as a coating material. The prepared nanoparticles were identifyed for their micromeritic and crystallographic properties, drug loading, particle size, drug release, Zeta potential, effective permeability (Peff) and oral fractional absorption. Intestinal permeability of VCM nanoparticles was figured out, in different concentrations using SPIP technique in rats. Results: Particle sizes were between 362 and 499 nm for different compositions of VCM-RS-100 nanoparticles. Entrapment efficiency expansed between 63%-94.76%. The highest entrapment efficiency 94.76% was obtained when the ratio of drug to polymer was 1:3. The in vitro release studies were accomplished in pH 7.4. The results showed that physicochemical properties were impressed by drug to polymer ratio. The FT-IR, XRPD and DSC results ruled out any chemical interaction betweenthe drug and RS-100. Effective intestinal permeability values of VCM nanoparticles in concentrations of 200, 300 and 400 ?g/ml were higher than that of solutions at the same concentrations. Oral fractional absorption was achieved between 0.419-0.767. Conclusion: Our findings suggest that RS-100 nanoparticles could provide a delivery system for VCM, with enhanced intestinal permeability. PMID:24312770

Loveymi, Badir Delf; Jelvehgari, Mitra; Zakeri-Milani, Parvin; Valizadeh, Hadi

2012-01-01

342

Risk Driven Requirements Specification (RiDeRS) of IT-based Homecare Systems  

E-print Network

, and include patients, their family, nurses, and other health care actors. This means that the concept of riskRisk Driven Requirements Specification (RiDeRS) of IT-based Homecare Systems Mohammad Zarifi Eslami, IT- based care systems can also introduce new types of risks such as those related to availability

Wieringa, Roel

343

The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets  

Microsoft Academic Search

INTRODUCTION: Angiogenesis is an important process in the development of destructive synovial pannus in rheumatoid arthritis (RA). The ITGAV +gene encodes a cell cycle-associated antigen, integrin ??? 3, which plays a role in RA angiogenesis. Previously, two independent studies identified an association between the major allele of the ITGAV single-nucleotide polymorphism (SNP) rs3738919 and RA. We therefore tested this association

Jade E Hollis-Moffatt; Kerry A Rowley; Amanda J Phipps-Green; Marilyn E Merriman; Nicola Dalbeth; Peter Gow; Andrew A Harrison; John Highton; Peter BB Jones; Lisa K Stamp; Pille Harrison; B Paul Wordsworth; Tony R Merriman

2009-01-01

344

Association between IL-21 gene rs907715 polymorphisms and Graves’ disease in a Southern Chinese population  

PubMed Central

Interleukin-21 (IL-21) is a pleiotropic cytokine linking innate and adaptive immune responses, which has been reported to play a key role in multiple autoimmune diseases. The aim of the present case-control study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of rs907715 within the IL-21 gene and Graves’ disease (GD) in a Southern Chinese population. A total of 211 patients with GD and 212 control subjects were recruited for the study. IL-21 gene rs907715 polymorphisms were detected by direct DNA sequencing. The results indicated that the frequencies of the GG genotype and the G allele in GD patients were significantly increased when compared with the frequencies in the controls (P=6.7×10?3 and P=2.0×10?5, respectively). In addition, the frequency of the AA genotype was much lower in the patient group when compared with the control group (16.6 vs. 34.0%; P=4.0×10?5). Furthermore, the G allele of rs907715 was associated with relapse in GD patients. These observations indicated that polymorphisms of IL-21/rs907715 may affect the susceptibility to GD in a Southern Chinese population. The G allele was significantly associated with an increased risk of GD development, whereas the A allele may lower the susceptibility to GD. PMID:24944624

ZENG, HUA; YAN, HAIYAN; ZHANG, ZHIXIAN; FANG, WEIZHEN; DING, RUI; HUANG, LISI; CHEN, MEI; ZHANG, JIN

2014-01-01

345

Association between Tumor Necrosis Factor-? rs1800629 Polymorphism and Risk of Asthma: A Meta-Analysis  

PubMed Central

Objective The purpose of this study was to explore the association between the TNF-? rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility. Methods We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. Results A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-? rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR?=?1.46, 95% CI 1.21–1.76, P<0.0001). Subgroup analyses found that the TNF-? rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR?=?2.47, 95% CI?=?1.48–4.12, P?=?0.0005; OR?=?1.83, 95% CI?=?1.42–2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR?=?1.51, 95% CI?=?1.24–1.83, P<0.0001), adults and children (OR?=?1.43, 95 CI%?=?1.07–1.91, P?=?0.02; OR?=?1.57, 95% CI?=?1.19–2.06, P?=?0.001). Conclusions This meta-analysis suggested that the rs1800629 polymorphism in TNF-? was a risk factor for asthma. PMID:24936650

Yang, Guangdie; Chen, Junjun; Xu, Fei; Bao, Zhang; Yao, Yake; Zhou, Jianying

2014-01-01

346

Remote Sens. 2014, 6, 2239-2254; doi:10.3390/rs6032239 remote sensing  

E-print Network

Remote Sens. 2014, 6, 2239-2254; doi:10.3390/rs6032239 remote sensing ISSN 2072-4292 www.mdpi.com/journal challenging [3]. Remote sensing technology, meanwhile, viewed as a time- and cost-efficient approach among International Center for Ecology, Meteorology and Environment, School of Applied Meteorology, Nanjing University

Chen, Jiquan

347

Remote Sens. 2013, 5, 4229-4254; doi:10.3390/rs5094229 Remote Sensing  

E-print Network

Remote Sens. 2013, 5, 4229-4254; doi:10.3390/rs5094229 Remote Sensing ISSN 2072-4292 www.mdpi.com/journal employs remote sensing data: Global Inventory Modeling and Mapping Studies (GIMMS) Maximum Normalized vegetation; climate variability; sea ice; Arctic 1. Background and Rationale The remotely sensed Normalized

Bhatt, Uma

348

Remote Sens. 2011, 3, 2529-2551; doi:10.3390/rs3112529 Remote Sensing  

E-print Network

Remote Sens. 2011, 3, 2529-2551; doi:10.3390/rs3112529 Remote Sensing ISSN 2072-4292 www.mdpi.com/journal-reviewed literature. Two recent special issues on UAS for environmental remote sensing applications in the journals Geocarto International [1] and GIScience and Remote Sensing [2] as well as other recent publications

349

Dynamometer Power Output Measurements of Piezoelectric Actuators E. Steltz and R.S. Fearing  

E-print Network

areas of robotics, such as to flap the wings of a micro air vehicle [1], to actuate control surfacesDynamometer Power Output Measurements of Piezoelectric Actuators E. Steltz and R.S. Fearing-- Piezoelectric bending actuators are an attractive option for driving microrobots due to their light weight

California at Berkeley, University of

350

Variability of multilevel switching in scaled hybrid RS/CMOS nanoelectronic circuits: theory  

NASA Astrophysics Data System (ADS)

A theory is presented which describes the variability of multilevel switching in scaled hybrid resistive-switching/CMOS nanoelectronic circuits. Variability is quantified in terms of conductance variation using the first two moments derived from the probability density function (PDF) of the RS conductance. For RS, which are based on the electrochemical metallization effect (ECM), this variability is - to some extent - caused by discrete events such as electrochemical reactions, which occur on atomic scale and are at random. The theory shows that the conductance variation depends on the joint interaction between the programming circuit and the resistive switch (RS), and explicitly quantifies the impact of RS device parameters and parameters of the programming circuit on the conductance variance. Using a current mirror as an exemplary programming circuit an upper limit of 2-4 bits (dependent on the filament surface area) is estimated as the storage capacity exploiting the multilevel capabilities of an ECM cell. The theoretical results were verified by Monte Carlo circuit simulations on a standard circuit simulation environment using an ECM device model which models the filament growth by a Poisson process. Contribution to the Topical Issue “International Semiconductor Conference Dresden-Grenoble - ISCDG 2012”, Edited by Gérard Ghibaudo, Francis Balestra and Simon Deleonibus.

Heittmann, Arne; Noll, Tobias G.

2013-07-01

351

RS-Forest: A Rapid Density Estimator for Streaming Anomaly Detection  

PubMed Central

Anomaly detection in streaming data is of high interest in numerous application domains. In this paper, we propose a novel one-class semi-supervised algorithm to detect anomalies in streaming data. Underlying the algorithm is a fast and accurate density estimator implemented by multiple fully randomized space trees (RS-Trees), named RS-Forest. The piecewise constant density estimate of each RS-tree is defined on the tree node into which an instance falls. Each incoming instance in a data stream is scored by the density estimates averaged over all trees in the forest. Two strategies, statistical attribute range estimation of high probability guarantee and dual node profiles for rapid model update, are seamlessly integrated into RS-Forest to systematically address the ever-evolving nature of data streams. We derive the theoretical upper bound for the proposed algorithm and analyze its asymptotic properties via bias-variance decomposition. Empirical comparisons to the state-of-the-art methods on multiple benchmark datasets demonstrate that the proposed method features high detection rate, fast response, and insensitivity to most of the parameter settings. Algorithm implementations and datasets are available upon request.

Wu, Ke; Zhang, Kun; Fan, Wei; Edwards, Andrea; Yu, Philip S.

2015-01-01

352

Sandstone cementation and fluids in hydrocarbon basins R.S. Haszeldinea,*, C.I. Macaulaya  

E-print Network

Sandstone cementation and fluids in hydrocarbon basins R.S. Haszeldinea,*, C.I. Macaulaya , A there is an intermediate view. Processes governing sandstone cementation in the deep sub-surface are elusive, case have driven studies of sandstone cementation in the past ten years: Firstly, the economic motive

Haszeldine, Stuart

353

Reactor Statics Module, RS-9: Multigroup Diffusion Program Using an Exponential Acceleration Technique.  

ERIC Educational Resources Information Center

The nine Reactor Statics Modules are designed to introduce students to the use of numerical methods and digital computers for calculation of neutron flux distributions in space and energy which are needed to calculate criticality, power distribution, and fuel burnup for both slow neutron and fast neutron fission reactors. The last module, RS-9,…

Macek, Victor C.

354

Liverpool Telescope Optical Photometry Following the 2006 Outburst of RS Ophiuchi  

E-print Network

We present a preliminary report on the broadband optical photometry of the 2006 outburst of the recurrent nova RS Ophiuchi. These data were obtained using the robotic 2m Liverpool Telescope and cover the outburst from day 27 through day 548.

M. J. Darnley; R. A. Hounsell; M. F. Bode

2008-09-26

355

MATH 590: Meshfree Methods Chapter 1: Introduction, Scattered Data Interpolation in Rs and  

E-print Network

590 ­ Chapter 1 8 #12;Introduction Energy renewable energy sector study of single wind turbinesMATH 590: Meshfree Methods Chapter 1: Introduction, Scattered Data Interpolation in Rs and MATLAB@iit.edu MATH 590 ­ Chapter 1 1 #12;Outline 1 Introduction 2 What are multivariate scattered data? 3

Fasshauer, Greg

356

ORD RESEARCH AND TECHNICAL SUPPORT AT EPA'S R.S. KERR ENVIRONMENTAL RESEARCH LABORATORY; ADA, OK  

EPA Science Inventory

EPA's Robert S. Kerr Environmental Research Laboratory is one of ten Office of Research and Development research laboratories. The R.S. Kerr Environmental Research Laboratory conducts EPA-investigator led laboratory and field research to provide the scientific basis to support t...

357

Association between a MYH9 polymorphism (rs3752462) and renal function in the Spanish RENASTUR cohort.  

PubMed

The MYH9 gene encodes a protein that is expressed in the kidney glomerular podocytes. MYH9 single nucleotide polymorphisms (SNPs) have been linked to the risk for chronic kidney disease (CKD) and end stage renal disease. Our aim was to determine whether MYH9 SNPs were associated with renal disease in Spanish Caucasians. The RENASTUR cohort consisted of 592 Spanish Caucasians, aged 55-85 years. They were genotyped for SNPs rs3752462 and rs4821480, which tagged haplotype E. The main values between individuals with a glomerular filtration rate (eGFR) <60 and ? 60 ml/min/1.73 m(2) were statistically compared. The next variables were significantly associated with the eGFR in the univariate analysis: age, gender, type 2 diabetes, total cholesterol, total LDL-cholesterol, and the MYH9 rs3752462 (TC+TT genotypes; p=0.003). This SNP remained significantly associated with the eGFR in the multivariate analysis. In conclusion, SNP rs3752462 was an independent predictor of reduced eGFR in the Spanish RENASTUR population. The genotyping of this MYH9 SNP could help to identify individuals at risk of developing CKD. PMID:23470845

Tavira, Beatriz; Coto, Eliecer; Gómez, Juan; Tranche, Salvador; Miguélez, Kevin; Ortega, Francisco; Díez, Beatriz; Sánchez, Emilio; Marín, Rafael; Arenas, Jorge; Alvarez, Victoria

2013-05-10

358

Association of Neuregulin 1 rs3924999 genotype with antisaccades and smooth pursuit eye movements.  

PubMed

Neuregulin 1 (NRG1) has been identified as one of the leading candidate genes for schizophrenia. However, its functional mechanisms and its effects on neurocognition remain unclear. In this study, we used two well-established oculomotor endophenotypes, the antisaccade (AS) and smooth pursuit eye movement (SPEM) tasks, to investigate the functional mechanisms of a single nucleotide polymorphism (SNP) in NRG1 (rs3924999) at the neurocognitive level in a healthy volunteer sample. A total of 114 healthy Caucasian volunteers completed genotyping for NRG1 rs3924999 and infrared oculographic assessment of AS and SPEM (at target velocities of 12 degrees , 24 degrees and 36 degrees per second). Additionally, self-report questionnaires of schizotypy, neuroticism, attention deficit hyperactivity and obsessive-compulsive traits were included. A significant effect of rs3924999 genotype, with gender as a covariate, was found for AS amplitude gain (P < 0.01), with an increasing number of A alleles being associated with increasingly hypermetric performance. No statistically significant associations were found for other AS and SPEM variables or questionnaire scores. These findings indicate that NRG1 rs3924999 affects spatial accuracy on the AS task, suggesting an influence of the gene on the neural mechanisms underlying visuospatial sensorimotor transformations, a mechanism that has been previously found to be impaired in patients with schizophrenia and their relatives. PMID:20497232

Schmechtig, A; Vassos, E; Kumari, V; Hutton, S B; Collier, D A; Morris, R G; Williams, S C R; Ettinger, U

2010-08-01

359

INTRODUCTION Recent studies have demonstrated that resting state fMRI (rs-fMRI) con-  

E-print Network

INTRODUCTION Recent studies have demonstrated that resting state fMRI (rs-fMRI) con- nectivity to the need for: (1) a training dataset, (2) a-priori information about informative connections, and a (3 PROCESSING AT THE SINGLE SUBJECT LEVEL USING WHOLE-BRAIN FMRI CONNECTIVITY METHODS ( Experimental Paradigm

Bandettini, Peter A.

360

It's all about being right: lessons from the R 6 RS process  

Microsoft Academic Search

In the Revised Reports on Scheme up to R5RS, the language could only be changed by unanimous consent. It has been widely believed that any language changes made in this way would clearly be the right thing. Arguably, this process reached its limits with the Revised5 Report on Scheme: Crucial language additions such as modules, records and exceptions had little

Michael Sperber

2009-01-01

361

Fusion Engineering and Design 38 (1997) 87113 Configuration and engineering design of the ARIES-RS  

E-print Network

-based power plant. The ARIES-RS engineering design process emphasized the attainment of the top-level missionFusion Engineering and Design 38 (1997) 87­113 Configuration and engineering design of the ARIES on the reversed-shear tokamak mode of plasma operation, and using moderately advanced engineering concepts

California at San Diego, University of

362

The Campylobacter jejuni?RacRS system regulates fumarate utilization in a low oxygen environment.  

PubMed

The natural environment of the human pathogen Campylobacter jejuni is the gastrointestinal tract of warm-blooded animals. In the gut, the availability of oxygen is limited; therefore, less efficient electron acceptors such as nitrate or fumarate are used by C. jejuni. The molecular mechanisms that regulate the activity of the highly branched respiratory chain of C. jejuni are still a mystery mainly because C. jejuni lacks homologues of transcription factors known to regulate energy metabolism in other bacteria. Here we demonstrate that dependent on the available electron acceptors the two-component system RacRS controls the production of fumarate from aspartate, as well as its transport and reduction to succinate. Transcription profiling, DNAse protection and functional assays showed that phosphorylated RacR binds to and represses at least five promoter elements located in front of genes involved in the uptake and synthesis of fumarate. The RacRS system is active in the presence of nitrate and trimethyl-amine-N-oxide under oxygen-limited conditions when fumarate is less preferred as an alternative electron acceptor. In the inactive state, RacRS allows utilization of fumarate for respiration. The unique C. jejuni?RacRS regulatory system illustrates the disparate evolution of Campylobacter and aids the survival of this pathogen. PMID:24707969

van der Stel, Anne-Xander; van Mourik, Andries; Heijmen-van Dijk, Linda; Parker, Craig T; Kelly, David J; van de Lest, Chris H A; van Putten, Jos P M; Wösten, Marc M S M

2014-04-01

363

RAPID COMMUNICATION: A simple test for high Jc and low Rs superconducting thin films  

NASA Astrophysics Data System (ADS)

A simple method, fishing high-Tc superconductor thin films out of a liquid nitrogen bath by a permanent magnet (field > Hc1), due to the effect of high flux pinning, has been suggested to identify films that have high critical current density (Jc > 106 A cm-2 at 77 K) and thus a low microwave surface resistance (Rs). We have demonstrated that a Nd-Fe-B magnet, having a maximum field of ~0.5 T, could fish out Tl-1223 superconducting thin films on LSAT substrate with a thickness of ~5000 Å having Jc > 1 MA cm-2 (at 77 K) whereas it could not fish out other films with Jc < 0.1 MA cm-2 at 77 K. The fished out films exhibit Rs values 237-245 µm at 77 K and 10 GHz, which is lower than that (Rs = 317 µm) of the commercially available YBCO film at the same temperature and frequency. On the other hand, the non-fishable films show very high Rs values. This method is a very simple tool to test for high Jc and good microwave properties of large area superconducting films which would otherwise require a special and expensive tool.

Sundaresan, A.; Tanaka, Y.; Iyo, A.; Kusunoki, M.; Ohshima, S.

2003-05-01

364

The cooling tower fan system fault monitoring based on the trunk of RS485  

Microsoft Academic Search

In this paper, in view of the present situation of fault monitoring of the cooling tower fan operation. New cooling tower fan fault monitoring system is designed , which is based on a set of PC ( as the host computer) , the microcontroller (as the next crew to the new RS485 bus) and a new monitoring method. This paper

Maoting Li; Xiaokai Gong; Wei Dong; Wenliang Li

2011-01-01

365

DHPG Activation of Group 1 mGluRs in BLA Enhances Fear Conditioning  

ERIC Educational Resources Information Center

Group 1 metabotropic glutamate receptors are known to play an important role in both synaptic plasticity and memory. We show that activating these receptors prior to fear conditioning by infusing the group 1 mGluR agonist, (R.S.)-3,5-dihydroxyphenylglycine (DHPG), into the basolateral region of the amygdala (BLA) of adult Sprague-Dawley rats…

Rudy, Jerry W.; Matus-Amat, Patricia

2009-01-01

366

Dublin, 11.09.2011 Star FormationStar FormationStar FormationStar Formation  

E-print Network

Dublin, 11.09.2011 Star FormationStar FormationStar FormationStar Formation An observational viewJ. Rowles, G. IoannidisJ. Rowles, G. Ioannidis #12;Dublin, 11.09.2011 Layout of the talkLayout of the talk on UWISH2 data #12;Dublin, 11.09.2011 GMCsGMCsGMCsGMCs Gravity and Turbulence dominate (maybe B

Froebrich, Dirk

367

Dibaryons in neutron stars  

NASA Technical Reports Server (NTRS)

The effects are studied of H-dibaryons on the structure of neutron stars. It was found that H particles could be present in neutron stars for a wide range of dibaryon masses. The appearance of dibaryons softens the equations of state, lowers the maximum neutron star mass, and affects the transport properties of dense matter. The parameter space is constrained for dibaryons by requiring that a 1.44 solar mass neutron star be gravitationally stable.

Olinto, Angela V.; Haensel, Pawel; Frieman, Joshua A.

1991-01-01

368

Hyper X-ray Flares on Active Stars Detected with MAXI  

NASA Astrophysics Data System (ADS)

MAXI started its operation in 2009 August. Owing to its unprecedentedly high sensitivity as an all-sky X-ray monitor and to its capability of real-time data transfer, we have detected 56 strong flares from twenty-one active stars (eleven RS CVn systems, one Algol system, seven dMe stars, one dKe star and one Young Stellar Object). These flares have large X-ray luminosity of 6 × 1030 -5 × 1033 ergs s-1 in the 2-20 keV band. The flares can be thought to be high ends among their own categories. During the flare from AT Mic on 2012 April 18th, one of the largest X-ray luminosities was recorded as a dMe star, 6 × 1032 ergs s-1 in the 2-20 keV band. It is larger than its bolometric luminosity by 4 times. The total energy emitted during the flare is 1036 ergs in the same band. Such total energy can be obtained on large flares from RS CVn system, but not on any other flares from dMe stars. In this proceeding, we report on the present situation in characteristics of hyper X-ray flares on each stellar categories.

Higa, Masaya; Tsuboi, Yohko; Negoro, Hitoshi; Nakahira, Satoshi; Tomida, Hiroshi; Matsuoka, Masaru; aff002

2014-08-01

369

RS-25 for the NASA Cargo Launch Vehicle: The Evolution of SSME for Space Exploration  

NASA Technical Reports Server (NTRS)

A key element of the National Vision for Space Exploration is the development of a heavy-lift Cargo Launch Vehicle (CaLV). Missions to the Moon, Mars, and beyond are only possible with the logistical capacity of putting large payloads in low-earth orbit. However, beyond simple logistics, there exists the need for this capability to be as cost effective as possible to ensure mission sustainability. An element of the CaLV project is, therefore, the development of the RS-25, which represents the evolution of the proven Space Shuttle Main Engine (SSME) into a high-performance, cost-effective expendable rocket engine. The development of the RS-25 will be built upon the foundation of over one million seconds of accumulated hot-fire time on the SSME. Yet in order to transform the reusable SSME into the more cost-effective, expendable RS-25 changes will have to be made. Thus the project will inevitably strive to maintain a balance between demonstrated heritage products and processes and the utilization of newer technology developments. Towards that end, the Core Stage Engine Office has been established at the NASA Marshall Space Flight Center to initiate the design and development of the RS-25 engine. This paper is being written very early in the formulation phase of the RS-25 project. Therefore the focus of this paper will be to present the scope, challenges, and opportunities for the RS-25 project. Early schedules and development decisions and plans will be explained. For not only must the RS-25 project achieve cost effectiveness through the development of new, evolved components such as a channel-wall nozzle, a new HIP-bonded main combustion chamber, and several others, it must simultaneously develop the means whereby this engine can be manufactured on a scale never envisioned for the SSME. Thus, while the overall project will span the next eight to ten years, there is little doubt that even this schedule is aggressive with a great deal of work to accomplish.

Kynard, Michael H.; McArthur, J. Craig; Ise, Dayna S.

2006-01-01

370

Life Cycles of Stars  

NSDL National Science Digital Library

This Powerpoint presentation inroduces younger students to the life cycles of stars. Topics include stellar nurseries, types of stars, supernovae, the fates of stars of either high or low mass, and the creation of heavier elements by continued fusion of successively heavier elements.

371

Van Maanen's Star  

NASA Astrophysics Data System (ADS)

This star in the constellation of Pisces, although faint, is of much importance as it is the nearest readily observable white dwarf—a class of star of considerable significance in studies of stellar evolution. The white dwarfs Sirius B and Procyon B are both closer, but their proximity to their much brighter companions makes them very difficult to study as individual stars....

Murdin, P.

2000-11-01

372

White Dwarf Stars  

Microsoft Academic Search

A white dwarf is a very dense star: The earth-sized remains of a Sun-like star that has burned all of its nuclear fuel. Although it's unable to carry out the workaday activities of a living star, a white dwarf is still an interesting object to astronomers. For one thing, white dwarfs experience \\

Steven Kawaler; Michael Dahlstrom

2000-01-01

373

Main Sequence Stars  

NSDL National Science Digital Library

This website from the Australian Telescope Outreach and Education group provides a thorough introduction to the life and death of stars. The website uses text, diagrams, and images to help explain how stars evolve. Highlights include a discussion of stellar fusion reactions and also a straightforward calculation of the lifetime of a star.

2009-12-08

374

Supernova Star Maps  

NSDL National Science Digital Library

This fun astronomy activity allows learners to experience finding stars in the night sky that will eventually go supernova. This activity is perfect for a star party outdoors. The PDF contains step-by-step instructions, photos, presentation tips, ready-to-print star maps, and links to background information.

Astronomical Society of the Pacific

2008-01-01

375

America's Star Libraries  

ERIC Educational Resources Information Center

"Library Journal"'s new national rating of public libraries, the "LJ" Index of Public Library Service, identifies 256 "star" libraries. It rates 7,115 public libraries. The top libraries in each group get five, four, or three Michelin guide-like stars. All included libraries, stars or not, can use their scores to learn from their peers and improve…

Lyons, Ray; Lance, Keith Curry

2009-01-01

376

Star formation Simon Goodwin  

E-print Network

Star formation Simon Goodwin Dept Physics & Astronomy, University of Sheffield, Hounsfield Road, Sheffield, S3 7RH, UK. s.goodwin@sheffield.ac.uk 1 Abstract Stars are one of the most important consituents of the Universe, and understanding their formation is crucial to many areas of astrophysics. Stars form from dense

Crowther, Paul

377

Analyzing Star Trails  

NSDL National Science Digital Library

In this activity, students examine a photograph of the night sky and answer questions about their observations. The picture, taken by a high school student in upstate New York, offers insight into the Earth's rotation, apparent star motion, the location of Polaris (the North Star), circumpolar constellations, and pointer stars.

Steve Kluge

378

Detection of the Molecular Zeeman Effect in Circular Polarization on Cool Active Stars  

E-print Network

We report on the first ever detection of circular polarization in molecular lines forming in magnetic regions on the surfaces of active stars. The new observations were obtained with the high-resolution spectropolarimeter ESPaDOnS recently installed at the Canada-France-Hawaii Telescope. In July 2005 we carried out a survey of 17 G-K-M stars including active main-sequence dwarfs and RS CVn-type giants and subgiants. All stars were found to possess surface magnetic fields producing average atomic Stokes V signals of 0.05% to 0.5%. Three stars clearly showed circular polarization in molecular lines of 0.5% to 1%. The molecular Stokes V signal is reminiscent of that observed in sunspots.

S. V. Berdyugina; P. Petit; D. M. Fluri; N. Afram; J. Arnaud

2007-03-21

379

The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans.  

PubMed

The antifungal plant defensin RsAFP2 isolated from radish interacts with fungal glucosylceramides and induces apoptosis in Candida albicans. To further unravel the mechanism of RsAFP2 antifungal action and tolerance mechanisms, we screened a library of 2868 heterozygous C.?albicans deletion mutants and identified 30 RsAFP2-hypersensitive mutants. The most prominent group of RsAFP2 tolerance genes was involved in cell wall integrity and hyphal growth/septin ring formation. Consistent with these genetic data, we demonstrated that RsAFP2 interacts with the cell wall of C.?albicans, which also contains glucosylceramides, and activates the cell wall integrity pathway. Moreover, we found that RsAFP2 induces mislocalization of septins and blocks the yeast-to-hypha transition in C.?albicans. Increased ceramide levels have previously been shown to result in apoptosis and septin mislocalization. Therefore, ceramide levels in C.?albicans membranes were analysed following RsAFP2 treatment and, as expected, increased accumulation of phytoC24-ceramides in membranes of RsAFP2-treated C.?albicans cells was detected. This is the first report on the interaction of a plant defensin with glucosylceramides in the fungal cell wall, causing cell wall stress, and on the effects of a defensin on septin localization and ceramide accumulation. PMID:22384976

Thevissen, Karin; de Mello Tavares, Patricia; Xu, Deming; Blankenship, Jill; Vandenbosch, Davy; Idkowiak-Baldys, Jolanta; Govaert, Gilmer; Bink, Anna; Rozental, Sonia; de Groot, Piet W J; Davis, Talya R; Kumamoto, Carol A; Vargas, Gabriele; Nimrichter, Leonardo; Coenye, Tom; Mitchell, Aaron; Roemer, Terry; Hannun, Yusuf A; Cammue, Bruno P A

2012-04-01

380

Impact of the functional status of saeRS on in vivo phenotypes of Staphylococcus aureus?sarA mutants.  

PubMed

We investigated the in vivo relevance of the impact of sarA and saeRS on protease production using derivatives of the USA300 strain LAC. The results confirmed that mutation of saeRS or sarA reduces virulence in a bacteremia model to a comparable degree. However, while eliminating protease production restored virulence in the sarA mutant, it had little impact in the saeRS mutant. Additionally, constitutive activation of saeRS (saeRS(C)) enhanced the virulence of LAC and largely restored virulence in the isogenic sarA mutant. Based on these results, together with our analysis of the representative virulence factors alpha toxin, protein A (Spa), and extracellular nucleases, we propose a model in which the attenuation of saeRS mutants is defined primarily by decreased production of such factors, while constitutive activation of saeRS increases virulence, and reverses the attenuation of sarA mutants, because it results in both increased production and decreased protease-mediated degradation of these same factors. This regulatory balance was also apparent in a murine model of catheter-associated infection, with the results suggesting that the impact of saeRS on nuclease production plays an important role during the early stages of these infections that is partially offset by increased protease production in sarA mutants. PMID:24779437

Beenken, Karen E; Mrak, Lara N; Zielinska, Agnieszka K; Atwood, Danielle N; Loughran, Allister J; Griffin, Linda M; Matthews, K Alice; Anthony, Allison M; Spencer, Horace J; Skinner, Robert A; Post, Ginell R; Lee, Chia Y; Smeltzer, Mark S

2014-06-01

381

Influence of the Two-Component System SaeRS on Global Gene Expression in Two Different Staphylococcus aureus Strains†  

PubMed Central

The two-component system SaeRS consisting of the histidin kinase SaeS and the response regulator SaeR is known to act on virulence gene expression in Staphylococcus aureus. In order to get a more comprehensive picture on SaeR-regulated genes, we studied the contribution of the two-component system on global gene expression by using both the proteomic and transcriptomic approach. Altogether, a loss of SaeRS resulted in a decreased amount of at least 17 extracellular proteins and two cell surface-associated proteins, among them several important virulence factors such as HlgA, HlgB, HlgC, LukF, and LukM. SaeRS activates the expression of these genes at the transcriptional level. The amount of the five proteins Aur, SspA, SsaA, Plc, and GlpQ was negatively influenced by SaeRS. However, the transcription of the corresponding genes was not affected by the two-component system. SaeRS had also no measurable influence on the transcription of the regulatory genes agr, sarA, arlRS, and sigB that contribute to the regulation of SaeRS-dependent virulence factors identified in this investigation. Our results clearly show that SaeRS is strongly involved in the tight temporal control of virulence factor expression in S. aureus. Its precise role within the regulatory network remains to be determined. PMID:17079681

Rogasch, Kathrin; Rühmling, Vanessa; Pané-Farré, Jan; Höper, Dirk; Weinberg, Christin; Fuchs, Stephan; Schmudde, Mareike; Bröker, Barbara M.; Wolz, Christiane; Hecker, Michael; Engelmann, Susanne

2006-01-01

382

The Apolipoprotein E Polymorphism rs7412 Associates with Body Fatness Independently of Plasma Lipids in Middle Aged Men  

PubMed Central

Background The apolipoprotein E (APOE) gene is polymorphic, encoding one of 3 common alleles (?2, ?3, ?4) produced from combinations of 2 non-synonymous SNPs (rs429358 and rs7412). APOE plays an important role controlling plasma lipids but its association with adipocyte functionality and body fatness remains to be determined. Methods We analyzed fasting plasma lipids and genotyped the two main APOE-SNPs (rs429358 and rs7412), both located in the fourth exon of the APOE, in 4660 Caucasian middle-aged men free of cardiovascular disease. Results The rs7412 SNP, which determines the APOE2 isoform, was significantly associated with Body Mass Index (BMI) and Waist Girth (WG) in a multivariate model accounting for age, smoking status and plasma lipids. BMI and WG were highest in TT homozygotes and lowest in CC homozygotes. This effect was independent of the rs429358 SNP, which failed to show any association with the BMI and WG variables. The odds ratio of being obese (BMI>30) for individuals carrying the APO?2 allele, present in 14% of the cohort and defined by the rs7412 SNP, was also significant in this multivariate model, with an OR of 1.27 (95% CI: 1.01–1.59). Conclusions This study provides an evidence of a lipid-independent association between the APOE SNP rs7412 and body fatness surrogates, BMI and WG, in a large cohort of middle-aged males. PMID:25268647

Tejedor, M. Teresa; Garcia-Sobreviela, Maria Pilar; Ledesma, Marta; Arbones-Mainar, Jose M.

2014-01-01

383

Human NPY Promoter Variation rs16147:T>C as a Moderator of Prefrontal NPY Gene Expression and Negative Affect  

PubMed Central

Studies in humans and animals suggest a role for NPY in the mediation of behavioral stress responses. Here, we examined whether the NPY promoter variant rs16147:T>C is functional for expression of NPY in a brain region relevant for behavioral control, anxiety and depression, the anterior cingulate cortex. In silico analysis of DNA structural profile changes produced by rs16147 variation suggests allelic differences in protein binding at the rs16147 site. This was confirmed by electrophoretic mobility shift assay, demonstrating that the rs16147 C-allele has strongly reduced affinity for a yet unknown factor compared to the T-allele. Analyzing 107 human post-mortem brain samples we show that allelic variation at rs16147 contributes to regulation of NPY mRNA and peptide levels in this region. Specifically, the C-allele leads to increased gene expression. In agreement with the molecular findings, rs16147:T>C is associated with anxiety and depressive symptoms in 314 young adults via a gene × environment interaction with early childhood adversity, replicating the recent finding of rs16147-C as a risk factor for stress related psychopathology. Our results show the importance of rs16147:T>C for regulation of NPY gene expression and brain function. PMID:20648632

Sommer, Wolfgang H.; Lidström, Jessica; Sun, Hui; Passer, Derek; Eskay, Robert; Parker, Stephen C.J.; Witt, Stephanie H.; Zimmermann, Ulrich S.; Nieratschker, Vanessa; Rietschel, Marcella; Margulies, Elliott H.; Palkovits, Miklós; Laucht, Manfred; Heilig, Markus

2010-01-01

384

Fusion Engineering and Design 38 (1997) 5986 Systems analysis in support of the selection of the ARIES-RS  

E-print Network

. Parametric sensitivities about the ARIES-RS reference design point are presented that illustrate the economic.A. Keywords: ARIES-RS reference design point; Parametric sensitivities; Systems analysis 1. Introduction of a lack of confidence in some scaling relations away from the reference value. Additionally, systems

385

A catalog of chromospherically active binary stars (second edition)  

NASA Technical Reports Server (NTRS)

The catalog contains 206 spectroscopic binary systems with at least one late-type component that shows Ca II H and K emission in its spectrum. These systems include the classical RS CVn binaries and BY Dra binaries. The catalog summarizes information on the photometric, spectroscopic, orbital, and physical properties of the systems as well as space motions and positions. Up to 42 'parameters' for each stellar system are listed followed by the appropriate reference to direct interested colleagues to the original papers. A comprehensive selection of further information for each star is given in the individual notes. In addition, the catalog contains a candidate list of 138 stars that have similar characteristics but are not definitely known binaries or have not had Ca II H and K emission observed.

Strassmeier, K. G.; Hall, D. S.; Fekel, F. C.; Scheck, M.

1993-01-01

386

Massive stars and star clusters in the Antennae galaxies  

E-print Network

Large numbers of young stars are formed in merging galaxies, such as the Antennae galaxies. Most of these stars are formed in compact star clusters (i.e., super star clusters), which have been the focus of a large number of studies. However, an increasing number of projects are beginning to focus on the individual stars as well. In this contribution, we examine a few results relevant to the triggering of star and star cluster formation; ask what fraction of stars form in the field rather than in clusters; and begin to explore the demographics of both the massive stars and star clusters in the Antennae. 1.

C. Whitmore

2006-01-01

387

Massive stars and star clusters in the Antennae galaxies  

E-print Network

Large numbers of young stars are formed in merging galaxies, such as the Antennae galaxies. Most of these stars are formed in compact star clusters (i.e., super star clusters), which have been the focus of a large number of studies. However, an increasing number of projects are beginning to focus on the individual stars as well. In this contribution, we examine a few results relevant to the triggering of star and star cluster formation; ask what fraction of stars form in the field rather than in clusters; and begin to explore the demographics of both the massive stars and star clusters in the Antennae.

Bradley C. Whitmore

2006-12-22

388

Virus-Encoded Aminoacyl-tRNA Synthetases: Structural and Functional Characterization of Mimivirus TyrRS and MetRS?  

PubMed Central

Aminoacyl-tRNA synthetases are pivotal in determining how the genetic code is translated in amino acids and in providing the substrate for protein synthesis. As such, they fulfill a key role in a process universally conserved in all cellular organisms from their most complex to their most reduced parasitic forms. In contrast, even complex viruses were not found to encode much translation machinery, with the exception of isolated components such as tRNAs. In this context, the discovery of four aminoacyl-tRNA synthetases encoded in the genome of mimivirus together with a full set of translation initiation, elongation, and termination factors appeared to blur what was once a clear frontier between the cellular and viral world. Functional studies of two mimivirus tRNA synthetases confirmed the MetRS specificity for methionine and the TyrRS specificity for tyrosine and conformity with the identity rules for tRNATyr for archea/eukarya. The atomic structure of the mimivirus tyrosyl-tRNA synthetase in complex with tyrosinol exhibits the typical fold and active-site organization of archaeal-type TyrRS. However, the viral enzyme presents a unique dimeric conformation and significant differences in its anticodon binding site. The present work suggests that mimivirus aminoacyl-tRNA synthetases function as regular translation enzymes in infected amoebas. Their phylogenetic classification does not suggest that they have been acquired recently by horizontal gene transfer from a cellular host but rather militates in favor of an intricate evolutionary relationship between large DNA viruses and ancestral eukaryotes. PMID:17855524

Abergel, Chantal; Rudinger-Thirion, Joëlle; Giegé, Richard; Claverie, Jean-Michel

2007-01-01

389

The active RS Canum Venaticorum binary II Pegasi. III. Chromospheric emission and flares in 1994-1996  

NASA Astrophysics Data System (ADS)

We analyse observations of the very active RS CVn-type star II Peg carried out simultaneously in chromospheric and photospheric lines in 1994-1996. We describe the correlation of the strength of the He i D3, Ca ii,K and Ca ii 8498 Ä emissions with the spot position on the stellar disk. A two-component structure is suggested in the chromosphere of II Peg, similar to that in the corona: nonvariable component (cool plages) with constant contribution to the line emission and variable, active one (hot plages) showing a growth of its activity during 1994-1996. The active component is related to the spots seen in the photosphere. Two subsequent flares on July 19-23, 1995 were observed in the He i D3 and Ca ii,K and 8498 Ä lines showing strong narrow red-shifted emissions. The development of the flares took a few hours and decay lasted several days. At the maximum of the flaring, in addition to the narrow components, broad blue-shifted emissions appeared in He i and Ca ii,K and in the cores of many strong absorption lines. The broad components are attributed to the process of the explosive evaporation from the low chromosphere. The amount of energy released in different lines is determined. From the radial velocity curve of the He i emission the location of the radiating matter is deduced. It appears to be related to the largest active region which is seen in the stellar image. The flare occurred concurrently with the break of the extended group on two well separated spots. On October 26, 1996 another flare was observed in three spectra, as narrow emissions in the He i and Ca ii,8498 Ä lines but without development in other lines. It probably was a late stage of the flare decay. Based on observations collected at the Nordic Optical Telescope (NOT), La Palma, Spain.

Berdyugina, S. V.; Ilyin, I.; Tuominen, I.

1999-09-01

390

Stars and Constellations  

NSDL National Science Digital Library

This site from Jim Kaler, a Professor of Astronomy at the University of Illinois, is geared toward amateur and budding astronomers. Kaler offers detailed but non-technical descriptions of selected stars and a link to a photo of their respective constellations. Another section of the site, The Natures of Stars, consists of basic overviews of key concepts. The star descriptions are interesting to beginner and avid starwatchers alike, but the photos would benefit perhaps from superimposed arrows or other finding aids. The Stars site grows by one celestial body each week: the Star of the Week from Kaler's other site, Skylights.

Kaler, James, B.

391

Neutron Star Collision  

NSDL National Science Digital Library

Systems of orbiting neutron stars are born when the cores of two old stars collapse in supernova explosions. Neutron stars have the mass of our Sun but are the size of a city, so dense that boundaries between atoms disappear. Einsteins theory of general relativity predicts that the orbit shrinks from ripples of space-time called gravitational waves. After about 1 billion simulation years, the two neutron stars closely circle each other at 60,000 revolutions per minute. The stars finally merge in a few milliseconds, sending out a burst of gravitational waves.

Dave Bock

1999-01-21

392

Magnetic chemically peculiar stars  

E-print Network

Chemically peculiar (CP) stars are main-sequence A and B stars with abnormally strong or weak lines for certain elements. They generally have magnetic fields and all observables tend to vary with the same period. Chemically peculiar stars provide a wealth of information; they are natural atomic and magnetic laboratories. After a brief historical overview, we discuss the general properties of the magnetic fields in CP stars, describe the oblique rotator model, explain the dependence of the magnetic field strength on the rotation, and concentrate at the end on HgMn stars.

Schöller, Markus

2015-01-01

393

Ponderable soliton stars  

NASA Technical Reports Server (NTRS)

The theory of Lee and Pang (1987), who obtained solutions for soliton stars composed of zero-temperature fermions and bosons, is applied here to quark soliton stars. Model soliton stars based on a simple physical model of the proton are computed, and the properties of the solitons are discussed, including the important problem of the existence of a limiting mass and thus the possible formation of black holes of primordial origin. It is shown that there is a definite mass limit for ponderable soliton stars, so that during cooling a soliton star might reach a stage beyond which no equilibrium configuration exists and the soliton star probably will collapse to become a black hole. The radiation of ponderable soliton stars may alter the short-wavelength character of the cosmic background radiation, and may be observed as highly redshifted objects at z of about 100,000.

Chiu, Hong-Yee

1990-01-01

394

Stars main sequence  

NSDL National Science Digital Library

What happens during most of a star's life? This activity page, part of an interactive laboratory series for grades 8-12, introduces students to the main sequence phase of a star's existence. This phase is where a star lives out the majority of its life. In an interactive lab activity, students predict the length of the main sequence for four different stars. The predictions can be printed for later evaluation. Students view diagrams that compare the size and color of stars to human lives, and equilibrium within a star is stressed. Finally, students choose between two hypotheses about the length of life of a star. Students write a one- to three-sentence explanation for their hypotheses. The correct answer is provided. Copyright 2005 Eisenhower National Clearinghouse

University of Utah. Astrophysics Science Project Integrating Research and Education (ASPIRE)

2003-01-01

395

A VLA radio-continuum survey of a sample of confirmed and marginal barium stars  

NASA Technical Reports Server (NTRS)

Results are reported from a 6-cm VLA survey of five confirmed Ba II stars and eight mild Ba II stars, undertaken to search for evidence of gyrosynchrotron emission or thermal emission from the primary star's wind that is enhanced or photoionized by a white dwarf companion. Of these 13 stars, only Beta UMi was detected as a possible radio source at a flux level of 0.11 mJy (3sigma). The 6-cm radio luminosities (L6) of the other stars are as small as log L6 less than or equal to 14.0 and are an order of magnitude or more lower than the average levels found in RS CVn systems, but are consistent with the L6 upper limits previously found for stars of spectral type similar to the Ba II stars and normal elemental abundances. The upper limit to the radio luminosity for the possible mild Ba II star 56 Peg, when combined with its previously known X-ray luminosity, may provide useful constraints on the various models that have been proposed for this interesting object, once its orbital period is known.

Drake, Stephen A.; Simon, Theodore; Linsky, Jeffrey L.

1987-01-01

396

Down Syndrome Related Muscle Hypotonia: Association with COL6A3 Functional SNP rs2270669  

PubMed Central

Down syndrome (DS), the principal cause for intellectual disability, is also associated with hormonal, immunological, and gastrointestinal abnormalities. Muscle hypotonia (MH) and congenital heart diseases (CHD) are also frequently observed. Collagen molecules are essential components for maintaining muscle integrity and are formed by the assembly of three chains, alpha 1–3. The type VI collagen is crucial for cardiac as well as skeletal muscles. The COL ?1 (VI) and ?2 (VI) chains are encoded by genes located at the 21st chromosome and are expected to have higher dosage in individuals with DS. The ? 3 (VI) chain is encoded by the COL6A3 located at the chromosome 2. We hypothesized that apart from COL6A1 and COL6A2, COL6A3 may also have some role in the MH of subjects with DS. To find out the relevance of COL6A3 in DS associated MH and CHD, we genotyped two SNPs in COL6A3, rs2270669 and rs2270668, in individuals with DS. Subjects with DS were recruited based on the Diagnostic and Statistical Manual for Mental Disorders-IV and having trisomy of the 21st chromosome. Parents of individuals with DS and ethnically matched controls were enrolled for comparison. Informed written consent was obtained for participation. Peripheral blood was used for isolation of genomic DNA. Target genetic loci were studied by DNA sequence analysis. Data obtained was subjected to population – as well as family-based statistical analysis. rs2270668 was found to be non-polymorphic in the studied population. rs2270669 showed significant association of the “C” allele and “CC” genotype with DS probands having MH (P?=?0.02). Computational analysis showed that rs2270669 may induce structural and functional alterations in the COL ?3 (VI). Interaction of COL?3 (VI) with different proteins, crucial for muscle integrity, was also noticed by computational methods. This pioneering study on COL6A3 with DS related MH thus indicates that rs2270669 “C” could be considered as a risk factor for DS related MH. PMID:23626599

Dey, Arpita; Bhowmik, Krishnendu; Chatterjee, Arpita; Chakrabarty, Pit Baran; Sinha, Swagata; Mukhopadhyay, Kanchan

2013-01-01

397

The Progenitor Masses of Wolf-Rayet Stars and Luminous Blue Variables Determined from Cluster Turn-offs. II. Results from 12 Galactic Clusters and OB Associations  

E-print Network

Here we examine 12 Galactic clusters and OB associations containing Wolf-Rayet stars (W-Rs) and/or Luminous Blue Variables (LBVs), in order to assess the progentor masses of these evolved massive stars. We find that in the Milky Way, early-type WN stars evolve from stars with masses as low as 20Mo. Some early-type WN stars are found in clusters with very high turn-off masses, supporting our earlier results that the "WNE" class of W-Rs is a common stage in the evolution of stars with a wide range of mases. In contrast, the late-type WNs (particularly those of WN7 class) and the LBVs are only found in clusters with the very highest turn-off masses, suggesting that only the most massive stars evolve to these objects. An examination of the environment of the archetype LBV Eta Car reveals that this star is coeval with the rest of the Tr14/16 association, suggesting that its LBV properties is a normal consequence of evolution, and has little to do with the possibility that it is a binary.

Massey, P; Waterhouse, E

2000-01-01

398

The Progenitor Masses of Wolf-Rayet Stars and Luminous Blue Variables Determined from Cluster Turn-offs. II. Results from 12 Galactic Clusters and OB Associations  

E-print Network

Here we examine 12 Galactic clusters and OB associations containing Wolf-Rayet stars (W-Rs) and/or Luminous Blue Variables (LBVs), in order to assess the progentor masses of these evolved massive stars. We find that in the Milky Way, early-type WN stars evolve from stars with masses as low as 20Mo. Some early-type WN stars are found in clusters with very high turn-off masses, supporting our earlier results that the "WNE" class of W-Rs is a common stage in the evolution of stars with a wide range of mases. In contrast, the late-type WNs (particularly those of WN7 class) and the LBVs are only found in clusters with the very highest turn-off masses, suggesting that only the most massive stars evolve to these objects. An examination of the environment of the archetype LBV Eta Car reveals that this star is coeval with the rest of the Tr14/16 association, suggesting that its LBV properties is a normal consequence of evolution, and has little to do with the possibility that it is a binary.

P. Massey; K. DeGioia-Eastwood; E. Waterhouse

2000-10-31

399

Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union.  

PubMed

Different government agencies operating in the European Union regulate different types of chemical products but all require testing for carcinogenicity to support applications for product marketing and commercialisation. A conference was held in Brussels in 2013 where representatives of the pharmaceutical, animal health, chemical and plant protection industries, together with representatives of regulatory agencies, universities and other stakeholders, met under the auspices of The European Partnership for Alternative Approaches to Animal Testing (EPAA) to discuss the varying requirements for carcinogenicity testing, and how these studies might be refined to improve hazard evaluation and risk assessment while implementing principles of the 3Rs (replacement, refinement and reduction in animal studies). While there are some similarities, the regulatory approaches in pharmaceutical, animal health, chemical and plant protection sectors have varying degrees of flexibility in requirements for carcinogenicity testing, to an extent reflecting concerns over the magnitude and duration of human exposure, either directly as in therapeutic exposure to pharmaceuticals, or indirectly through the ingestion of residues of veterinary drugs or plant protection chemicals. The article discusses these differences and other considerations for modified carcinogenicity testing paradigms on the basis of scientific and 3Rs approaches. PMID:24768934

Annys, Erwin; Billington, Richard; Clayton, Rick; Bremm, Klaus-Dieter; Graziano, Michael; McKelvie, Jo; Ragan, Ian; Schwarz, Michael; van der Laan, Jan Willem; Wood, Charles; Öberg, Mattias; Wester, Piet; Woodward, Kevin N

2014-07-01

400

The NOD2 p.Leu1007fsX1008 Mutation (rs2066847) Is a Stronger Predictor of the Clinical Course of Crohn's Disease than the FOXO3A Intron Variant rs12212067  

PubMed Central

Background Very recently, a sub-analysis of genome-wide association scans revealed that the non-coding single nucleotide polymorphism (SNP) rs12212067 in the FOXO3A gene is associated with a milder course of Crohn's disease (CD) (Cell 2013;155:57–69). The aim of our study was to evaluate the clinical value of the SNP rs12212067 in predicting the severity of CD by correlating CD patient genotype status with the most relevant complications of CD such as stenoses, fistulas, and CD-related surgery. Methodology/Principal Findings We genotyped 550 CD patients for rs12212067 (FOXO3A) and the three common CD-associated NOD2 mutations rs2066844, rs2066847, and rs2066847 and performed genotype-phenotype analyses. Results No significant phenotypic differences were found between the wild-type genotype TT of the FOXO3A SNP rs12212067 and the minor genotypes TG and GG independently from NOD2 variants. The allele frequency of the minor G allele was 12.7%. Age at diagnosis, disease duration, body mass index, surgery rate, stenoses, fistula, need for immunosuppressive therapy, and disease course were not significantly different. In contrast, the NOD2 mutant p.Leu1007fsX1008 (rs2066847) was highly associated with penetrating CD (p?=?0.01), the development of fistulas (p?=?0.01) and stenoses (p?=?0.01), and ileal disease localization (p?=?0.03). Importantly, the NOD2 SNP rs2066847 was a strong separator between an aggressive and a mild course of CD (p?=?2.99×10?5), while the FOXO3A SNP rs12212067 did not separate between mild and aggressive CD behavior in our cohort (p?=?0.35). 96.2% of the homozygous NOD2 p.Leu1007fsX1008 carriers had an aggressive disease behavior compared to 69.3% of the patients with the NOD2 wild-type genotype (p?=?0.007). Conclusion/Significance In clinical practice, the NOD2 variant p.Leu1007fsX1008 (rs2066847), in particular in homozygous form, is a much stronger marker for a severe clinical phenotype than the FOXO3A rs12212067 SNP for a mild disease course on an individual patient level despite its important impact on the inflammatory response of monocytes. PMID:25365249

Wolf, Christiane; Angelberger, Marianne; Diegelmann, Julia; Olszak, Torsten; Beigel, Florian; Tillack, Cornelia; Stallhofer, Johannes; Göke, Burkhard; Glas, Jürgen; Lohse, Peter; Brand, Stephan

2014-01-01

401

Vitamin D3 Receptor (VDR) Gene rs2228570 (Fok1) and rs731236 (Taq1) Variants Are Not Associated with the Risk for Multiple Sclerosis: Results of a New Study and a Meta-Analysis  

PubMed Central

Background Some epidemiological, genetic, and experimental data suggest a possible role of vitamin D in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis. Data on the possible contribution of several single nucleotide polymorphisms (SNP) in the vitamin D receptor (VDR) gene to the risk for MS are controversial. Several studies suggested an interaction between some SNPs in the VDR gene and HLADRB1*1501 in the risk for MS. Objectives The aim of this study was to investigate a possible influence of the SNPs rs2228570 and rs731236 in the VDR gene in the risk for MS. A secondary objective was to address the possible interactions between VDR genes and HLADRB1*1501. Methods We analyzed the allelic and genotype frequency of VDR rs2228570, rs731236, and HLADRB1*1501 (rs3135388) in 303 patients with MS and 310 healthy controls, using TaqMan Assays. We also conducted a meta-analysis, that was carried out by using the software Meta-Disc 1.1.1 (http://www.hrc.es/investigacion/metadisc.html; Unit of Clinical Statistics, Hospital Ramón y Cajal, Madrid, Spain). Heterogeneity between studies in terms of degree of association was tested using the Q-statistic. Results VDR rs2228570 and rs731236 allelic and genotype frequencies did not differ significantly between MS patients and controls, and were unrelated with the age of onset of MS, gender, and course of MS. HLADRB1*1501 showed a high association with the risk of developing MS 4.76(95% C.I. ?=?3.14–7.27; p<0.0001). The meta-analysis, after excluding data of one study that was responsible of heterogeneity for rs731236 polymorphism, showed lack of relation of both SNPs with the risk for MS. HLADRB1*1501 showed lack of interaction with VDR rs2228570 and rs731236 in increasing MS risk. Conclusions These results suggest that VDR rs2228570 and rs731236 polymorphisms are not related with the risk for MS, and did not confirm interaction between these VDR SNPs and HLADRB1 in the risk for MS. PMID:23840333

García-Martín, Elena; Agúndez, José A. G.; Martínez, Carmen; Benito-León, Julián; Millán-Pascual, Jorge; Calleja, Patricia; Díaz-Sánchez, María; Pisa, Diana; Turpín-Fenoll, Laura; Alonso-Navarro, Hortensia; Ayuso-Peralta, Lucía; Torrecillas, Dolores; Plaza-Nieto, José Francisco; Jiménez-Jiménez, Félix Javier

2013-01-01

402

Disks around HAEBE stars  

NASA Astrophysics Data System (ADS)

Do Herbig Ae/Be stars have accretion disks like T Tauri stars? We report the detection of 850 micron continuum emission toward 21 of 33 HAEBE stars in a JCMT mapping and archival survey; more than half the sample was observed at 450 micron as well. Of the detected sources, eight show extended, disk-like dust emission centered on the star. The others are unresolved in our beam, suggesting that the dust envelopes or disks around these stars are less than a few arcsec, similar to the sizes of envelopes and disks seen toward most T Tauri stars. Several of the detected but unresolved stars (e.g., MWC 297, Elias 1, HD 142666) have very flat SEDs in the submillimeter, suggesting the presence of dust with unusual properties or disks with large dust grains or planetesimals. These disks may be on the verge of forming planetary systems. Many HAEBE stars lie in regions of extended dust emission; quite often, however, our maps show that the strongest submillimeter emission originates from younger, optically invisible, heavily embedded sources rather than from the HAEBE stars. Mapping therefore is essential in order to determine whether the submillimeter or far-infrared emission detected in large beam measurements is from a HAEBE star, nearby protostars or merely from the dust cloud in which the star is embedded. In addition to already known cases like R CrA, LkHa 198, and BD+40 4124, where the submillimeter emission is dominated by emission from heavily embedded Class I or Class 0 sources, we find several other regions where the same is true or where the dust emission comes the surrounding PDR/molecular cloud interface, but not from the star itself. Only one star, the extremely distant MWC 300, showed no emission at all in the SCUBA field of view. Guest User, Canadian Astronomy Data Center, which is operated by the Dominion Astrophysical Observatory for the National Research Council of Canada's Herzberg Institute of Astrophysics.

Sandell, G.; Weintraub, D. A.

2002-05-01

403

Contribution of Human Fc?Rs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies  

PubMed Central

The biological activities of human IgG antibodies predominantly rely on a family of receptors for the Fc portion of IgG, Fc?Rs: Fc?RI, Fc?RIIA, Fc?RIIB, Fc?RIIC, Fc?RIIIA, Fc?RIIIB, FcRL5, FcRn, and TRIM21. All Fc?Rs bind IgG at the cell surface, except FcRn and TRIM21 that bind IgG once internalized. The affinity of Fc?Rs for IgG is determined by polymorphisms of human Fc?Rs and ranges from 2?×?104 to 8?×?107?M?1. The biological functions of Fc?Rs extend from cellular activation or inhibition, IgG-internalization/endocytosis/phagocytosis to IgG transport and recycling. This review focuses on human Fc?Rs and intends to present an overview of the current understanding of how these receptors may contribute to various pathologies. It will define Fc?Rs and their polymorphic variants, their affinity for human IgG subclasses, and review the associations found between Fc?R polymorphisms and human pathologies. It will also describe the human Fc?R-transgenic mice that have been used to study the role of these receptors in autoimmune, inflammatory, and allergic disease models. PMID:24910634

Gillis, Caitlin; Gouel-Chéron, Aurélie; Jönsson, Friederike; Bruhns, Pierre

2014-01-01

404

RANK rs1805034 T>C Polymorphism Is Associated with Susceptibility of Esophageal Cancer in a Chinese Population  

PubMed Central

Esophageal cancer remains the sixth leading cause of cancer associated death and eighth most common cancer worldwide. Genetic factors, such as single nucleotide polymorphisms (SNPs), may contribute to the carcinogenesis of esophageal cancer. Here, we conducted a hospital based case-control study to evaluate the genetic susceptibility of functional SNPs on the development of esophageal cancer. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were enrolled for this study. The OPG rs3102735 T>C, rs2073618 G>C, RANK rs1805034 T>C, RANKL rs9533156 T>C and rs2277438 A>G were determined by ligation detection reaction method. Our findings suggested that RANK rs1805034 T>C is associated with the susceptibility of ESCC, which is more evident in male and elder (?63) patients. Our study provides the first evidence that functional polymorphisms RANK rs1805034 T>C may be an indicator for individual susceptibility to ESCC. However, further larger studies among different ethnic populations are warranted to verify our conclusion. PMID:25019155

Tang, Weifeng; Wang, Xu; Lv, Lu; Shao, Aizhong; Shi, Yijun; Ding, Guowen; Chen, Suocheng; Gu, Haiyong

2014-01-01

405

Crystal structure of human mitochondrial PheRS complexed with tRNA(Phe) in the active "open" state.  

PubMed

Monomeric human mitochondrial phenylalanyl-tRNA synthetase (PheRS), or hmPheRS, is the smallest known enzyme exhibiting aminoacylation activity. HmPheRS consists of only two structural domains and differs markedly from heterodimeric eukaryotic cytosolic and bacterial analogs both in the domain organization and in the mode of tRNA binding. Here, we describe the first crystal structure of mitochondrial aminoacyl-tRNA synthetase (aaRS) complexed with tRNA at a resolution of 3.0 Å. Unlike bacterial PheRSs, the hmPheRS recognizes C74, the G1-C72 base pair, and the "discriminator" base A73, proposed to contribute to tRNA(Phe) identity in the yeast mitochondrial enzyme. An interaction of the tRNA acceptor stem with the signature motif 2 residues of hmPheRS is of critical importance for the stabilization of the CCA-extended conformation and its correct placement in the synthetic site of the enzyme. The crystal structure of hmPheRS-tRNA(Phe) provides direct evidence that the formation of the complex with tRNA requires a significant rearrangement of the anticodon-binding domain from the "closed" to the productive "open" state. Global repositioning of the domain is tRNA modulated and governed by long-range electrostatic interactions. PMID:22137894

Klipcan, Liron; Moor, Nina; Finarov, Igal; Kessler, Naama; Sukhanova, Maria; Safro, Mark G

2012-01-20

406

TNFAIP3 rs2230926 polymorphisms in rheumatoid arthritis of southern Chinese Han population: a case-control study  

PubMed Central

Polymorphism of tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been be related to various auto-immune diseases. Based on previous studies that the single nucleotide polymorphism (SNP) of rs2230926 was association with rheumatoid arthritis (RA) of Japanese, Caucasian population and the northern Chinese Han population, we tested the alleles and geno-type frequencies of rs2230926 in TNFAIP3 to investigate whether rs2230926 is susceptible to RA of southern Chinese Han population. In our case-control association study, 207 RA patients fulfilling the American College of Rheumatology (ACR) 1987 criteria were compared with 199 unrelated healthy subjects. After testing the alleles and genotype frequencies of rs2230926, the airwise linkage disequilibrium (LD) was computed and odd ration (OR) and 95% confidence intervals (95% CI) were used for evaluating the susceptibility to RA. The SNP of rs2230926 of the cases and control subjects were conformed to the Hardy-Weinberg equilibrium (P = 0.02257). The significantly statistical differences in alleles of T, G were founded in the cases and controls (P = 0.0027, OR 0.417, 95% CI 0.232-0.749); the genetic types of rs2230926 were associated with a susceptibility to RA, with OR 0.375 (95% CI 0.198-0.707, P = 0.0018). In the present study, our results indicated that the genetic polymorphism of rs2230926 in TNFAIP3 may be a susceptible factor conferring risk for RA in southern Chinese Han population.

Hao, Guifeng; Li, Yasong; Liu, Jinlin; Wo, Mingyi

2014-01-01

407

Association of genetic polymorphisms of SAA1 (rs12218) with myocardial infarction in a Chinese population.  

PubMed

Previous studies suggested that genetic polymorphisms of serum amyloid A (SAA) were associated with carotid atherosclerosis. However, the relationship between genetic polymorphisms of SAA and myocardial infarction (MI) remains unclear. In the present study, we analyzed a polymorphism (rs12218) in the SAA1 gene in 840 MI patients and 840 healthy subjects by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We found that the rs12218 CC+CT genotype was more frequent among MI patients than among healthy controls (61.1% vs 41.9%; P < 0.001). Multivariate regression analysis showed that after adjustment for gender, age, smoking, drinking, hypertension, and diabetes, the difference remained significant (P < 0.001, odds ratio = 3.332, 95% confidence interval = 1.781-9.231). Therefore, we concluded that genetic polymorphisms of SAA1 may be a genetic marker of MI in the Chinese population. PMID:24854450

Wang, B Y; Hang, J Y; Zhong, Y; Tan, S J

2014-01-01

408

Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample.  

PubMed

Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes. PMID:25098474

Cordeiro, Quirino; Vallada, Homero

2014-08-01

409

[Mapping a new secalin locus on the rye iRS arm].  

PubMed

A gene designated Sec-N encoding secalin was mapped in the introgressive winter common wheat line Hostianum 273/97 (H273) with the wheat-rye substitution (1B)1R from the octoploid triticale AD825. F2 seeds from crossing the line H273 with the line Hostianum 242/97-2 carrying the wheat-rye 1BL/1RS translocation were analysed. The studied component on the SDS-electrophoregram of total proteins was revealed to be a monomeric secalin which is encoded by the gene at the new locus Sec-N located distally with respect to the Sec-1 locus at a distance of 21.4 +/- 2.5% (22.9 +/- 3.1 cM). The arrangement of the secalin loci on the 1RS arm indicates that the Sec-N locus is to be homoeologous to the Gli-1 loci of common wheat. PMID:25184199

Kozub, N O; Motsny?, I I; Sozinov, I O; Blium, Ia B; Sizinov, O O

2014-01-01

410

Detection of an X-ray flare in the RS CVn binary Sigma Corona Borealis  

NASA Technical Reports Server (NTRS)

The first observation of a time-resolved X-ray flare in an RS CVn binary is reported. The X-ray flare was detected from the RS CVn binary Sigma CrB on August 17, 1980 during the course of a long pointed-mode observation with the Monitor Proportional Counter on the Einstein Observatory. The flare commenced at about 11:12 UT and lasted for about 205 minutes. During the flare the count rate increased by a factor of five from a quiescent state value of 0.3 count/s to a peak value of 1.5 count/s in the 1.2-10.2-keV energy band. The source spectrum during the flare was found to be considerably harder than that observed in the quiescent state. Details of the various characteristics of the X-ray flare are described.

Agrawal, P. C.; Rao, A. R.; Riegler, G. R.; Stern, R.

1983-01-01

411

Convergence of FPR-rs3-expressing neurons in the mouse accessory olfactory bulb.  

PubMed

In the mouse, most members of the FPR receptor family are expressed by vomeronasal sensory neurons. The neural circuitry corresponding to this class of chemical sensors is unknown. Taking advantage of the presence of FPR-rs3 on both vomeronasal dendrites and axonal fibers, we visualized the distribution of sensory cells expressing this member of the FPR family, and their corresponding axonal projections in the olfactory bulb. We found a rostrocaudal gradient of receptor choice frequency in the vomeronasal sensory neuroepithelium, and observed a convergence of FPR-rs3 axons into multiple, linked and deeply located glomeruli. These were homogenously innervated, and spatially restricted to the basal portion of the rostral accessory olfactory bulb. This organization, reminiscent of the one that characterizes axonal projections of V1R-expressing neurons, supports a role played by these receptors in the perception of semiochemicals. PMID:23664818

Dietschi, Quentin; Assens, Alexis; Challet, Ludivine; Carleton, Alan; Rodriguez, Ivan

2013-09-01

412

The RS Canum Venaticorum characteristics of the infrared light curves of Algol  

NASA Astrophysics Data System (ADS)

The 1.2-micron infrared light curve of Algol has been analyzed to determine the nature of the large scatter in the observations. This scatter is the result of time-dependent changes in the depths and phases of both eclipses, and in the asymmetric shape of secondary minimum. These changes can be explained by cyclic variations in the mean temperature of the secondary and by a photometric distortion of the light curve. This type of variability is similar to that seen in the optical light curves of RS Canum Venaticorum (or RS CVn) binaries which are distorted by the motions of starspots on the chromospherically active K-type secondaries in these systems. The discovery of similar photometric distortions in the 1.2-micron light curve of Algol provides evidence of starspot activity. In particular, this activity is associated with the K2 subgiant secondary in Algol.

Richards, Mercedes T.

1990-02-01

413

[Estimation of forest volume in Huzhong forest area based on RS, GIS and ANN].  

PubMed

Based on remote sensing (RS) which has integrated and realistic characteristics, geographic information system (GIS) which has powerful spatial analysis ability, and artificial neutral network (ANN) which can optimize nonlinear complex systems, the forest volume in Huzhong forest area was estimated. The results showed that there was an obvious negative correlation between the forest volume and infrared band, indicating that infrared band had definite potential in estimating forest volume. The forest volume also negatively correlated with visible band and PC1. Among the topographic factors, altitude exerted more influence than aspect and slope on the estimation of forest volume. The correlation coefficient of predicted value and actual value reached to 0.973, when the optimal ANN parameter, suitable GIS information, and RS bands were adopted. After principal component transformation, the amount of observation data was effectively reduced, while the predicted precision only had a small decline (R2 = 0.934). PMID:19102299

Liu, Zhi-Hua; Chang, Yu; Chen, Hong-Wei

2008-09-01

414

MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis  

PubMed Central

MicroRNAs (miRNAs) are small non-coding RNAs of ~22 nucleotides that function as negative regulators of gene expression by either inhibiting translation or inducing deadenylation-dependent degradation of target transcripts. Notably, deregulation of miRNAs expression is associated with the initiation and progression of human cancers where they act as oncogenes or tumor suppressors contributing to tumorigenesis. Abnormal miRNA expression may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic targets in cancer. Recently, several miRNAs have been shown to initiate invasion and metastasis by targeting multiple proteins that are major players in these cellular events, thus they have been denominated as metastamiRs. Here, we present a review of the current knowledge of miRNAs in cancer with a special focus on metastamiRs. In addition we discuss their potential use as novel specific markers for cancer progression. PMID:22408395

Lopez-Camarillo, Cesar; Marchat, Laurence A.; Arechaga-Ocampo, Elena; Perez-Plasencia, Carlos; del Moral-Hernandez, Oscar; Castaneda-Ortiz, Elizabeth J.; Rodriguez-Cuevas, Sergio

2012-01-01

415

A survey of knowledge of the three Rs concept among lecturers and postgraduate students in Brazil.  

PubMed

The use of animals in science is a widespread practice, despite growing concern about its moral justification and scientific relevance. In this scenario, the Three Rs concept might be considered to be a motivation for the establishment of a new scientific approach to the use of experimental animals and to research itself. The main objective of this survey-based study was to identify the level of knowledge about this concept among lecturers (i.e. tenure-track professors) and postgraduate students in the physiological and pharmaceutical sciences in Brazilian universities. A questionnaire was completed by 185 lecturers from 16 universities, and 140 postgraduate students from five of these universities. The results indicate that the concept of the Three Rs is widespread among lecturers and students in the areas of physiology and pharmacology, throughout Brazilian universities, but that its interpretation generally attributes more importance to refinement than to reduction and replacement. PMID:24901906

Tréz, de A Thales

2014-05-01

416

rs3746444 polymorphism and susceptibility to hepatocellular carcinoma: evidence from published studies.  

PubMed

The present study was undertaken to quantitatively evaluate the association between rs3746444 polymorphism and HCC risk. In this analysis with 667 cancer cases and 1,006 control subjects, we summarized 4 eligible case-control studies by searching databases of PubMed, EMBASE, and CNKI. The strength of the association was assessed by calculating odds ratios (ORs) with 95 % confidence intervals (CIs) with the fixed-effects model. We found that neither the allele frequency nor genotype distribution of this polymorphism was associated with risk of HCC in any genetic model. Similarly, no associations were suggested either in subgroup analyses by ethnicity or by source of control. Our research suggested that rs3746444 polymorphism may not be a risk factor for HCC. However, well-designed studies with a larger sample size are needed to confirm these findings. PMID:25074528

Liu, Fangfeng; Lin, Hongfeng; Cheng, Ying; Yang, Lei; Liu, Yongfeng

2014-12-01

417

Genetic variation in oxytocin rs2740210 and early adversity associated with postpartum depression and breastfeeding duration.  

PubMed

Mothers vary in duration of breastfeeding. These individual differences are related to a variety of demographic and individual maternal factors including maternal hormones, mood and early experiences. However, little is known about the role of genetic factors. We studied single-nucleotide polymorphisms (SNPs) in the OXT peptide gene (rs2740210; rs4813627) and the OXT receptor gene (OXTR rs237885) in two samples of mothers from the Maternal adversity, Vulnerability and Neurodevelopment study (MAVAN), a multicenter (Hamilton and Montreal, Canada) study following mothers and their children from pregnancy until 7?years of age. Data from the Hamilton site was the primary sample (n?=?201) and data from Montreal was the replication sample (n?=?151). Breastfeeding duration, maternal mood (measured by the CES-D scale) and early life adversity (measured by the CTQ scale) were established during 12?months postpartum. In our primary sample, polymorphisms in OXT rs2740210, but not the other SNPs, interacted with early life adversity to predict variation in breastfeeding duration (overall F8,125 ?=?2.361, P?=?0.021; interaction effect b?=?-8.12, t?=?-2.3, P?=?0.023) and depression (overall F8,118 ?=?5.751, P???0.001; interaction effect b?=?6.06, t?=?3.13, P?=?0.002). A moderated mediation model showed that higher levels of depression mediated the inverse relation of high levels of early life adversity to breastfeeding duration, but only in women possessing the CC genotype [effect a'?=?-3.3401, 95% confidence interval (CI)?=?-7.9466 to -0.0015] of the OXT SNP and not in women with the AA/AC genotype (a'?=?-1.2942, ns). The latter findings (moderated mediation model) were replicated in our Montreal sample (a'?=?-0.277, 95% CI?=?-0.7987 to -0.0348 for CC; a'?=?-0.1820, ns for AA/AC). PMID:23941164

Jonas, W; Mileva-Seitz, V; Girard, A W; Bisceglia, R; Kennedy, J L; Sokolowski, M; Meaney, M J; Fleming, A S; Steiner, M

2013-10-01

418

Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder.  

PubMed

Here we report the association of the rs694539 variant of nicotinamide-N-methyltransferase gene with bipolar disorder in a case-control study of 95 bipolar disorder patients and 201 healthy controls (?(2)=13.382, P=0.001). With the polymerase chain reaction restriction fragment length polymorphism method we developed we were able to show the association for the first time. This new finding may provide evidence to understand the mechanism of the disease. PMID:24004542

Sazci, Ali; Ozel, Mavi Deniz; Ergul, Emel; Onder, Mehmet Emin

2013-12-15

419

Utilization of Ceramic Uranium Fuels in ARIES-RS Fusion Reactor  

Microsoft Academic Search

This study presents the neutronic performance of the ARIES-RS fusion reactor design using different natural ceramic uranium fuels, namely UO2, UN or U3Si2, dispersed in graphite matrix. These fissionable fuels inserted as micro spheres into the first range quadratic channels at the immediate neighborhood of the first wall in the inboard blanket to amplify fusion power and breed fissile fuel.

Mustafa Übeyli

2004-01-01

420

Neutronic investigation of a hybrid version of the ARIES-RS fusion reactor  

Microsoft Academic Search

A hybrid version of the ARIES-RS of the commercial 1000 MWel power plant design concepts is investigated. A 10 cm fission zone at the inner blanket leads to a blanket multiplication of M=1.946 with ThC fuel or M=3.03 with UC fuel and increasing the fusion power from 2170 to 4200 MW or to 6500 MW, respectively. Despite a partial replacement

Sümer ?ahin; ?enay Yalç?n; Hac? Mehmet ?ahin; Mustafa Übeyli

2003-01-01

421

RS CVn-binary RW COM - A possible three-body system  

Microsoft Academic Search

The first detailed period study of the eclipsing RS CVn-binary system RW Com is presented. A new period (P = 0.2373455 d) based on 223 minima is given. The O-C diagrams of RW Com have been presented for the first time. Period changes in different portions of the O-C diagram have been estimated. The total change in period ranges from

R. K. Srivastava

1987-01-01

422

RS CVn-binary RW com: A possible three-body system  

Microsoft Academic Search

A first detailed period study of the eclipsing RS CVn-binary system RW Com is presented. A new period (P=0d.2373455) based on 223 minima is given. The O-C diagrams of RW Com have been presented for the first time. Types of ten minima have been corrected judging the period trend. Period changes in different portions of the O-C diagram (Figure 2)

R. K. Srivastava

1987-01-01

423

A Tool for Long-Range Dependent Analysis via the R\\/S Statistic  

Microsoft Academic Search

Self-similarity and long-range dependence have been found to apply as models of traffic in modern computer networks. This behavior has important implications for the design, analysis, control and performance of such networks, thus an accurate identification and quantification of such behavior is important. A novel tool for the analysis of long-range dependence via the R\\/S statistic is presented. The tool,

Julio C. Ramirez Pacheco; Deni Torres Roman

2006-01-01

424

Molecular cytogenetic identification of a novel 1AL.1RS translocation line with powdery mildew resistance.  

PubMed

A wheat germplasm line 13-2-2 with resistance to powdery mildew was isolated; this line was derived from common wheat cv. W770B and rye, Secale cereale L. (2n = 2x = 14, RR). The line was characterized based on cytological, genomic in situ hybridization (GISH), sequence-characterized amplified region (SCAR), and simple sequence repeat (SSR) analyses. The mitotic and meiotic investigations showed that the chromosome number and configuration of 13-2-2 were 2n = 42 = 21 II. GISH using rye genomic DNA as a probe detected a pair of R genome chromosome arms with strong hybridization signals in 13-2-2. Three 1RS chromosome-specific SCAR markers amplified 1RS specific bands in line 13-2-2. We screened 320 SSR primer pairs on the long or short arms from seven wheat homoeologous groups in the translocation line and parents. However, only three 1AS primers could not be amplified in line 13-2-2, whereas the others were amplified. Thus, these markers suggested that the line 13-2-2 was 1AL.1RS translocation line. Line 13-2-2 was immune to powdery mildew after inoculation with Blumeria graminis f. sp. tritici isolates E05 and E07 during the adult plant stages. In contrast, the maternal parent W770B, Kavkaz with Pm8, and Amigo with Pm17 were heavily infected with spores and had reaction response scores of susceptible. Thus, the new wheat-rye 1AL.1RS translocation line with resistance to powdery mildew could be a new and valuable donor source for wheat improvement. The molecular markers developed in this study might also be useful tools for marker-assisted selection. PMID:25526189

Lu, M; Wang, L; Zhang, J; Sun, S; Li, Y; Du, W; Wu, J; Zhao, J; Yang, Q; Chen, X

2014-01-01

425

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome: A case report  

Microsoft Academic Search

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare form of paraneoplastic tenosynovitis, which is more prone to occur in elderly males. A 78-year-old male had a past history of gastric cancer 23 years ago and underwent subtotal gastrectomy then. He led a fair life after the surgery. However, fever, edema in four extremities, gait disturbance, and liver

Yi-Ming Chen; Liang-Kung Chen; Shinn-Jang Hwang; Der-Yuan Chen; Hidenori Arai

2011-01-01

426

Configuration and engineering design of the ARIES-RS tokamak power plant  

Microsoft Academic Search

ARIES-RS is a conceptual design study which has examined the potential of an advanced tokamak-based power plant to compete with future energy sources and play a significant role in the future energy market. The design is a 1000 MWe, DT-burning fusion power plant based on the reversed-shear tokamak mode of plasma operation, and using moderately advanced engineering concepts such as

M. S. Tillack; S. Malang; L. Waganer; X. R. Wang; D. K. Sze; L. El-Guebaly; C. P. C. Wong; J. A. Crowell; T. K. Mau; L. Bromberg

1997-01-01

427

Hubble Space Telescope Imaging of the Expanding Nebular Remnant of the 2006 Outburst of RS Ophiuchi  

E-print Network

We report {\\it Hubble Space Telescope} imaging obtained 155 days and 449 days after the 2006 outburst of RS Ophiuchi. Both epochs show evidence of extended emission, consistent with that seen in earlier radio observations, and a maximum expansion rate of $3200\\pm300$ km s$^{-1}$ (in the plane of the sky). The extended structure is consistent with the remnant having a bipolar morphology with an inclination similar to that determined for the binary.

D. J. Harman; M. F. Bode; M. J. Darnley; T. J. O'Brien; H. E. Bond; S. Starrfield; A. Evans; S. P. S. Eyres; V. A. R. M. Ribeiro; J. M. Echevarria

2008-09-26

428

Association between BMP4 rs17563 Polymorphism and NSCL/P Risk: A Meta-Analysis  

PubMed Central

Objective. To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk. Methods. Four online databases were researched and the related publications were collected. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results. Results. Six published case-control studies were collected. Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found. It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis. For Chinese population, the BMP4 rs17563 polymorphism was a significantly increased risk for NSCL/P (C versus T: OR = 1.52, 95% CI = 1.28–1.82, P < 0.01, I2 = 0%; CC versus TT: OR = 2.58, 95% CI = 1.74–3.82, P < 0.01, I2 = 0%; TC + CC versus TT: OR = 1.45, 95% CI = 1.14–1.84, P < 0.01, I2 = 0%; CC versus TT + TC: OR=2.46, 95% CI = 1.46–4.14, P < 0.01, I2 = 47.0%). On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50–0.96, P = 0.03, I2 = 68.5%; TC versus TT: OR = 0.52, 95% CI = 0.40–0.68, P < 0.01, I2 = 0%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35–0.78, P < 0.010, I2 = 54.4%). Conclusion. This meta-analysis indicated that BMP4 rs17563 polymorphism could play a different role during the development of NSCL/P based on ethnicity diversity. PMID:25648829

Hu, Yuan-Yuan; Qin, Chuan-Qi; Deng, Mo-Hong; Niu, Yu-Ming; Long, Xing

2015-01-01

429

Comprehensive assessment of the association between XPD rs13181 polymorphism and lung cancer risk.  

PubMed

Xeroderma pigmentosum group D (XPD) rs13181 may reduce DNA repair capacity (DRC) through modifying XPD protein product. Reduced DRC is reportedly related to an increase in the risk of lung cancer. To precisely estimate the association between XPD rs13181 and lung cancer risk, we carried out the current meta-analysis. We searched multiple databases (up to 31 October 2013) for studies investigating the association of XPD rs13181 and lung cancer. Odds ratio (OR) was estimated with the fixed effect model to assess the association. Heterogeneity between studies was measured using Q test. Subgroup analyses were conducted by ethnicity, histological type, and sample size. Meta-analysis of 30 studies suggested that individuals carrying Gln/Gln genotype were more likely than the individuals with Lys/Lys or Lys/Gln + Lys/Lys genotypes (homozygous model, OR 1.18, 95 % confidence interval (CI) 1.07-1.31; recessive model, OR 1.17, 95 % CI 1.06-1.29) to develop lung cancer, without any substantial heterogeneity. This significantly increased risk was also revealed in the individuals harboring Gln/Gln + Lys/Gln genotypes (dominant model, OR 1.07, 95 % CI 1.01-1.12). Further stratification by histological type, ethnicity, and sample size yielded statistically significant estimates in subgroup of Caucasian subjects, non-small cell lung cancer, and relatively large studies, but borderline association in Asians. Our analyses demonstrate that XPD rs13181 may be associated with an increase in the risk of lung cancer among Caucasian populations. PMID:24845027

Wu, Hai-Ying; Ding, Ling-Yu

2014-08-01

430

Differential expression patterns of conserved miRNAs and isomiRs during Atlantic halibut development  

PubMed Central

Background MicroRNAs (miRNAs) play a major role in animal ontogenesis. Size variants of miRNAs, isomiRs, are observed along with the main miRNA types, but their origin and possible biological role are uncovered yet. Developmental profiles of miRNAs have been reported in few fish species only and, to our knowledge, differential expressions of isomiRs have not yet been shown during fish development. Atlantic halibut, Hippoglossus hippoglossus L., undergoes dramatic metamorphosis during early development from symmetrical pelagic larval stage to unsymmetrical flatfish. No data exist on role of miRNAs in halibut metamorphosis. Results miRNA profiling using SOLiD deep sequencing technology revealed a total of 199 conserved, one novel antisense, and one miRNA* mature form. Digital expression profiles of selected miRNAs were validated using reverse transcription quantitative PCR. We found developmental transition-specific miRNA expression. Expression of some miRNA* exceeded the guide strand miRNA. We revealed that nucleotide truncations and/or additions at the 3' end of mature miRNAs resulted in size variants showing differential expression patterns during the development in a number of miRNA families. We confirmed the presence of isomiRs by cloning and Sanger sequencing. Also, we found inverse relationship between expression levels of sense/antisense miRNAs during halibut development. Conclusion Developmental transitions during early development of Atlantic halibut are associated with expression of certain miRNA types. IsomiRs are abundant and often show differential expression during the development. PMID:22233483

2012-01-01

431

The mapping reflected-energy sensor-MaRS: a new level of hyperspectral technology  

NASA Astrophysics Data System (ADS)

The need to provide high-quality large-area hyperspectral data for land use, geological, environmental, and mapping applications is critical to the US Government in the 21st Century. Technological advances with regard to larger focal plane arrays (FPA) along with maturing spectrometer designs have made it possible for the development of a next generation system beyond AVIRIS. This paper will introduce the MaRS system along with some data examples from Cuprite, NV and the National Arboretum.

Simi, Christopher; Reith, Ernest; Olchowski, Fred

2009-08-01

432

Identification of ANKK1 rs1800497 variant in schizophrenia: new data and meta-analysis.  

PubMed

One functional polymorphism (rs1800497) within the ankyrin repeat and kinase domain containing-1 gene (ANKK1) was reported to be associated with schizophrenia, but results among different studies vary and conclusions remain controversial. The present study sought to clarify this potential association among a population of Han Chinese with early onset schizophrenia using a case-control (396 patients and 399 controls) and family based study (103 trios). We then performed a meta-analysis (comprising 11 case-control and 2 family-based studies) based on the present literature. Results of the association study revealed no significant difference in allele and genotype frequencies between the cases and controls, and no significant transmission distortion was detected. Kaplan-Meier survival analysis showed that age at onset in schizophrenia was significantly associated with the rs1800497 polymorphism in female patients, but not in males. Female T allele carriers had a lower age at onset than those without T allele (log rank statistic ?(2)?=?5.16, P?=?0.023; corrected P?=?0.046). Meta-analysis results indicated that rs1800497 is not associated with schizophrenia in the overall population (P?=?0.77 for the case-control studies; P?=?0.06 for the family-based studies). Our results support the hypothesis that rs1800497 polymorphism is likely to have a modifying rather than causative effect on schizophrenia. These findings may represent a significant genetic clue for the etiology of schizophrenia in females, but further investigation is required to clarify the exact role of ANKK1 in the development of schizophrenia. PMID:25073965

Zhang, Chen; Zhang, Jiangtao; Fan, Juan; Cheng, Wenhong; Du, Yasong; Yu, Shunying; Fang, Yiru

2014-10-01

433

Intercomparison of humidity and temperature sensors: GTS1, Vaisala RS80, and CFH  

Microsoft Academic Search

GTS1 digital radiosonde, developed by the Shanghai Changwang Meteorological Science and Technology Company in 1998, is now\\u000a widely used in operational radiosonde stations in China. A preliminary comparison of simultaneous humidity measurements by\\u000a the GTS1 radiosonde, the Vaisala RS80 radiosonde, and the Cryogenic Frostpoint Hygrometer (CFH), launched at Kunming in August\\u000a 2009, reveals a large dry bias produced by the

Jianchun Bian; Hongbin Chen; Holger Vömel; Yunjun Duan; Yuejian Xuan; Daren Lü

2011-01-01

434

SNP rs6265 Regulates Protein Phosphorylation and Osteoblast Differentiation and Influences BMD in Humans  

PubMed Central

Bone Mineral Density (BMD) is major index for diagnosing osteoporosis. PhosSNPs are non-synonymous SNPs that affect protein phosphorylation. The relevance and significance of phosSNPs to BMD and osteoporosis is unknown. This study aims to identify and characterize phosSNPs significant for BMD in humans. We conducted a pilot genome-wide phosSNP association study for BMD in three independent population samples, involving ~5,000 unrelated individuals. We identified and replicated three phosSNPs associated with both spine BMD and hip BMD in Caucasians. Association with hip BMD for one of these phosSNPs, i.e., rs6265 (major/minor allele: G/A) in BDNF gene, was also suggested in Chinese. Consistently in both ethnicities, individuals carrying AA genotype have significant lower hip BMD than carriers of GA and GG genotypes. Through in vitro molecular and cellular studies, we found that compared to osteoblastic cells transfected with wild-type BDNF-Val66 (encoded with allele G at rs6265), transfection of variant BDNF-Met66 (encoded with allele A at rs6265) significantly decreased BDNF protein phosphorylation (at amino acid residue T62), expression of osteoblastic genes (OPN, BMP2, and ALP), and osteoblastic activity. The findings are consistent with and explain our prior observations in general human populations. We conclude that phosSNP rs6265, via regulating BDNF protein phosphorylation and osteoblast differentiation, influence hip BMD in humans. This study represents our first endeavor to dissect the functions of phosSNPs in bone, which might stimulate extended large-scale studies on bone or similar studies on other human complex traits and diseases. PMID:23712400

Deng, Fei-Yan; Tan, Li-Jun; Shen, Hui; Liu, Yong-Jun; Liu, Yao-Zhong; Li, Jian; Zhu, Xue-Zhen; Chen, Xiang-Ding; Tian, Qing; Zhao, Ming; Deng, Hong-Wen

2013-01-01

435

Test results of the RS44 integrated component evaluator liquid oxygen\\/hydrogen rocket engine  

Microsoft Academic Search

An advanced LOX\\/LH2 expander cycle rocket engine, producing 15,000 lbf thrust for Orbital Transfer Vehicle missions, was tested to determine ignition, transition, and main stage characteristics. Detail design and fabrication of the pump fed RS44 integrated component evaluator (ICE) was accomplished using company discretionary resources and was tested under this contracted effort. Successful demonstrations were completed to about the 50

R. F. Sutton; B. W. Lariviere

1993-01-01

436

MISSION: MaRS Innovation will convert the outstanding discoveries of its partner institutions into products and services, making a significant  

E-print Network

MISSION: MaRS Innovation will convert the outstanding discoveries of its partner institutions of life of Canadians and others around the world. VISION: MaRS Innovation will transform the Toronto-based research enterprise into one of the most successful commercialization clusters in the world. MaRS

Sun, Yu

437

The Interaction Effects of pri-let-7a-1 rs10739971 with PGC and ERCC6 Gene Polymorphisms in Gastric Cancer and Atrophic Gastritis  

PubMed Central

Background The aim of this study was to investigate the interaction effects of pri-let-7a-1 rs10739971 with pepsinogen C (PGC) and excision repair cross complementing group 6 (ERCC6) gene polymorphisms and its association with the risks of gastric cancer and atrophic gastritis. We hoped to identify miRNA polymorphism or a combination of several polymorphisms that could serve as biomarkers for predicting the risk of gastric cancer and its precancerous diseases. Methods Sequenom MassARRAY platform method was used to detect polymorphisms of pri-let-7a-1 rs10739971 G?A, PGC rs4711690 C?G, PGC rs6458238 G?A, PGC rs9471643 G?C, and ERCC6 rs1917799 in 471 gastric cancer patients, 645 atrophic gastritis patients and 717 controls. Results An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (Pinteraction?=?0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (Pinteraction?=?0.012) and PGC rs9471643 polymorphism (Pinteraction?=?0.039) were observed for the risk of atrophic gastritis. Conclusion The combination of pri-let-7a-1 rs10739971 polymorphism and ERCC6 and PGC polymorphisms could provide a greater prediction potential than a single polymorphism on its own. Large-scale studies and molecular mechanism research are needed to confirm our findings. PMID:24586594

Xu, Qian; Liu, Jing-wei; He, Cai-yun; Sun, Li-ping; Gong, Yue-hua; Jing, Jing-jing; Xing, Cheng-zhong; Yuan, Yuan

2014-01-01

438

Ultrasensitive resonance scattering (RS) spectral detection for trace tetracycline in milk using aptamer-coated nanogold (ACNG) as a catalyst.  

PubMed

This paper reports an ultrasensitive resonance scattering (RS) method to detect tetracycline (TET) in milk based on the competition of aptamers between nanogold and TET, aggregation of naked nanogold, nanocatalytic Fehling reaction, and RS signals of catalytic product Cu?O cubic. The detection principle was confirmed by the nanoparticle size analyzer (NANOS), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The variations of RS intensity had good linear correlation with TET concentrations, and the limit of detection was calculated as 11.6 nM. The proposed method was successfully applied for analysis of TET in milk, with total recoveries ranging from 105 to 109%. PMID:24400926

Luo, Yanfang; He, Lan; Zhan, Shenshan; Wu, Yuangen; Liu, Le; Zhi, Wenting; Zhou, Pei

2014-02-01

439

Activity in F stars  

NASA Technical Reports Server (NTRS)

Measurements of He I 5876 A and IUE measurements of chromospheric and transition region lines in a large sample of F-type stars are presented. The data show that activity is detectable in nearly all early F-type stars and differs in several of its characteristics from that typically seen in cooler stars with slow rotation and fully developed convective zones. The onset of activity occurs near B-V = 0.28, which corresponds approximately to spectral type F0 and T(eff) = 7300 K. There is no correlation between the level of activity and the abundances of lithium and beryllium in F stars hotter than T(eff) = 6600 K. All but one of the stars in the 6600-7300 K temperature interval are active. The levels of activity in these stars are independent of Rossby number.

Wolff, Sidney C.; Boesgaard, Ann Merchant; Simon, Theodore

1986-01-01

440

The First Stars  

NASA Astrophysics Data System (ADS)

The standard cosmological model predicts that the first cosmological objects are formed when the age of the universe is a few hundred million years. Recent theoretical studies and numerical simulations consistently suggest that the first objects are very massive primordial stars. We introduce the key physics and explain why the first stars are thought to be massive, rather than to be low-mass stars. The state-of-the-art simulations include all the relevant atomic and molecular physics to follow the thermal evolution of a prestellar gas cloud to very high ``stellar'' densities. Evolutionary calculations of the primordial stars suggest the formation of massive blackholes in the early universe. Finally, we show the results from high-resolution simulations of star formation in a low-metallicity gas. Vigorous fragmentation is triggered in a star-forming gas cloud at a metallicity of as low as Z = 10-5Zsolar.

Yoshida, Naoki

2010-10-01

441

Early X-ray emission from novae: The case of the symbiotic recurrent nova RS Ophiuchi  

NASA Astrophysics Data System (ADS)

Novae can be sources of high-energy photons, reaching GeV energies. Such emission is a consequence of ?^{0} decay and/or Inverse Compton, which are related to particle (p and e^{-}) acceleration. The strong shock between matter ejected by the white dwarf and the circumstellar medium is responsible for this process. The 2006 outburst of RS Ophiuchi was the first nova for which particle acceleration was predicted. This prediction showed that the blast wave decelerated faster than expected as a consequence of acceleration of particles in the shock and their escape. RS Oph is a recurrent nova in a symbiotic system composed of a white dwarf and a red giant with a recurrence period of ˜ 21 years. Five novae have been detected by Fermi/LAT so far. Our aim is to understand the acceleration process through the analysis of contemporaneous X-ray emission. We present an analysis of the XMM-Newton's observations of RS Oph early after its 2006 outburst both with RGS and EPIC-MOS, which have a broader energy range than RGS. We will compare with RXTE, Swift/BAT and Chandra observations, to get a global picture of VHE ?-ray emission in novae and its relationship with particle acceleration.

Delgado, L.; Hernanz, M.

2014-07-01

442

?-XRF/?-RS vs. SR ?-XRD for pigment identification in illuminated manuscripts  

NASA Astrophysics Data System (ADS)

For the non-destructive identification of pigments and colorants in works of art, in archaeological and in forensic materials, a wide range of analytical techniques can be used. Bearing in mind that every method holds particular limitations, two complementary spectroscopic techniques, namely confocal ?-Raman spectroscopy (?-RS) and ?-X-ray fluorescence spectroscopy (?-XRF), were joined in one instrument. The combined ?-XRF and ?-RS device, called PRAXIS unites both complementary techniques in one mobile setup, which allows ?- and in situ analysis. ?-XRF allows one to collect elemental and spatially-resolved information in a non-destructive way on major and minor constituents of a variety of materials. However, the main disadvantages of ?-XRF are the penetration depth of the X-rays and the fact that only elements and not specific molecular combinations of elements can be detected. As a result ?-XRF is often not specific enough to identify the pigments within complex mixtures. Confocal Raman microscopy (?-RS) can offer a surplus as molecular information can be obtained from single pigment grains. However, in some cases the presence of a strong fluorescence background limits the applicability. In this paper, the concrete analytical possibilities of the combined PRAXIS device are evaluated by comparing the results on an illuminated sheet of parchment with the analytical information supplied by synchrotron radiation ?-X-ray diffraction (SR ?-XRD), a highly specific technique.

van der Snickt, G.; de Nolf, W.; Vekemans, B.; Janssens, K.

2008-07-01

443

Bitter peptides activate hTAS2Rs, the human bitter receptors  

PubMed Central

Fermented food contains numerous peptides derived from material proteins. Bitter peptides formed during the fermentation process are responsible for the bitter taste of fermented food. We investigated whether human bitter receptors (hTAS2Rs) recognize bitterness of peptides with a heterologous expression system. HEK293 cells expressing hTAS2R1, hTAS2R4, hTAS2R14, and hTAS2R16 responded to bitter casein digests. Among those cells, the hTAS2R1-expressing cell was most strongly activated by the synthesized bitter peptides Gly-Phe and Gly-Leu, and none of the cells was activated by the non-bitter dipeptide Gly-Gly. The results showed that these bitter peptides, as well as many other bitter compounds, activate hTAS2Rs, suggesting that humans utilize these hTAS2Rs to recognize and perceive the structure and bitterness of peptides. PMID:18037373

Maehashi, Kenji; Matano, Mami; Wang, Hong; Vo, Lynn A.; Yamamoto, Yasushi; Huang, Liquan

2008-01-01

444

Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility  

PubMed Central

Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants. The rs16892766 (8q23.3) polymorphism was first identified to be significantly associated with CRC in European ancestry. The following studies investigated this association in Chinese, Japanese, Romanian, Swedish, African American, European American, and Croatian populations. These studies reported consistent and inconsistent results. Here, we reevaluated this association using the relatively large-scale samples from 13 studies (N = 59737, 26237 cases and 33500 controls) using a meta-analysis by searching the PubMed, Google Scholar and CRCgene databases. We observed no significant heterogeneity among the included studies. Our results showed significant association between rs16892766 polymorphism and CRC (P = 1.33E-35, OR = 1.23, 95% CI 1.20-1.27). Collectively, our analysis further supports previous findings that the rs16892766 polymorphism is significantly associated with CRC susceptibility. We believe that our findings will be very useful for future genetic studies on CRC. PMID:25609216

Liao, Mingzhi; Wang, Guangyu; Quan, Baoku; Qi, Xingsi; Yu, Zhihui; Feng, Rennan; Zhang, Liangcai; Jiang, Yongshuai; Zhang, Yanqiao; Liu, Guiyou

2015-01-01

445

Experimental methods and prediction with COSMO-RS to determine partition coefficients in complex surfactant systems.  

PubMed

Surfactant-based separation processes are a promising alternative to conventional organic solvent processes. A crucial parameter to describe the efficiency of such processes is the partition coefficient between the surfactant aggregates (micelles) and the aqueous bulk phase. In this work, several experimental methods to determine these partition coefficients (micellar liquid chromatography, micellar enhanced ultrafiltration, and cloud point extraction) are evaluated and compared. In addition, these results are compared to predictions with the thermodynamic model COSMO-RS. In particular, systems with the nonionic surfactant TritonX-100 are studied. The partition equilibria of various solutes (pyrene, naphthalene, phenanthrene, phenol, 3-methoxyphenol, and vanillin) and the influence of different additives (alcohols) are investigated. All experimental methods show very good reproducibility. Moreover, the results from different methods are in good agreement, supplementing one another concerning the temperature ranges. Notably, the COSMO-RS model is capable of predicting partition coefficients between micelles and water in the investigated temperature range and at different alcohol concentrations. The results demonstrate the potential of the model COSMO-RS to facilitate the selection of optimized process parameters for a given separation problem. By predicting partition equilibria in multicomponent systems, the selection of surfactant, temperature, and appropriate additives can be facilitated. PMID:22091584

Mehling, Tanja; Ingram, Thomas; Smirnova, Irina

2012-01-10

446

Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility.  

PubMed

Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants. The rs16892766 (8q23.3) polymorphism was first identified to be significantly associated with CRC in European ancestry. The following studies investigated this association in Chinese, Japanese, Romanian, Swedish, African American, European American, and Croatian populations. These studies reported consistent and inconsistent results. Here, we reevaluated this association using the relatively large-scale samples from 13 studies (N = 59737, 26237 cases and 33500 controls) using a meta-analysis by searching the PubMed, Google Scholar and CRCgene databases. We observed no significant heterogeneity among the included studies. Our results showed significant association between rs16892766 polymorphism and CRC (P = 1.33E-35, OR = 1.23, 95% CI 1.20-1.27). Collectively, our analysis further supports previous findings that the rs16892766 polymorphism is significantly associated with CRC susceptibility. We believe that our findings will be very useful for future genetic studies on CRC. PMID:25609216

Liao, Mingzhi; Wang, Guangyu; Quan, Baoku; Qi, Xingsi; Yu, Zhihui; Feng, Rennan; Zhang, Liangcai; Jiang, Yongshuai; Zhang, Yanqiao; Liu, Guiyou

2015-01-01