Sample records for star rs cnc

  1. HI and CO in the circumstellar environment of the S-type star RS Cnc

    E-print Network

    Libert, Yannick; Bertre, Thibaut Le; Gérard, Eric; Matthews, Lynn D

    2010-01-01

    This paper presents interferometric and single-dish CO observations along with HI data obtained for the oxygen-rich semi-regular variable RS Cnc, in order to probe its circumstellar environment at different scales. With the Plateau de Bure Interferometer and the IRAM 30-m telescope, we detect both the CO(1-0) and the CO(2-1) rotational lines from RS Cnc. The line profiles are composite, with two components of half-width ~2 km/s and ~8 km/s respectively. Whereas the narrow velocity component seems to originate from an equatorial disk in the central part of the CO envelope, the broad component reveals a bipolar structure, with a north-south velocity gradient. In addition, we obtain new HI data on the source and around it in a field of almost 1 square degree. The HI line is centered at v_LSR = 7 km/s in agreement with CO observations. A new reduction process reveals a complex extended structure in the northwest direction, of estimated size ~18 arcmin, with a PA (~310 degrees) opposite to the direction of the ste...

  2. The multi-scale environment of RS Cnc from CO and HI observations

    E-print Network

    Hoai, D T; Winters, J M; Nhung, P T; Gérard, E; Libert, Y; Bertre, T Le

    2014-01-01

    We present a detailed study of the circumstellar gas distribution and kinematics of the semi-regular variable star RS Cnc on spatial scales ranging from ~1" (~150 AU) to ~6' (~0.25 pc). New modeling of CO1-0 and CO2-1 imaging observations leads to a revised characterization of RS Cnc's previously identified axisymmetric molecular outflow. Rather than a simple disk-outflow picture, we find that a gradient in velocity as a function of latitude is needed to fit the spatially resolved spectra, and in our preferred model, the density and the velocity vary smoothly from the equatorial plane to the polar axis. In terms of density, the source appears quasi-spherical, whereas in terms of velocity the source is axi-symmetric with a low expansion velocity in the equatorial plane and faster outflows in the polar directions. The flux of matter is also larger in the polar directions than in the equatorial plane. An implication of our model is that the stellar wind is still accelerated at radii larger than a few hundred AU,...

  3. On the central symmetry of the circumstellar envelope of RS Cnc

    E-print Network

    Nhung, Pham Tuyet; Winters, Jan Martin; Darriulat, Pierre; Gérard, Eric; Bertre, Thibaut Le

    2014-01-01

    We present a phenomenological study of CO(1-0) and CO(2-1) emission from the circumstellar envelope (CSE) of the Asymptotic Giant Branch (AGB) star RS\\,Cnc. It reveals departures from central symmetry that turn out to be efficient tools for the exploration of some of the CSE properties. We use a wind model including a bipolar flow with a typical wind velocity of $\\sim$8 km\\,s$^{-1}$ decreasing to $\\sim$2 km\\,s$^{-1}$ near the equator to describe Doppler velocity spectral maps obtained by merging data collected at the IRAM Plateau de Bure Interferometer and Pico Veleta single dish radio telescope. Parameters describing the wind morphology and kinematics are obtained, together with the radial dependence of the gas temperature in the domain of the circumstellar envelope probed by the CO observations. Significant north-south central asymmetries are revealed by the analysis, which we quantify using a simple phenomenological description. The origin of such asymmetries is unclear.

  4. Infrared photometry of the RS CVn short-period systems - XY UMa and WY Cnc

    SciTech Connect

    Arevalo, M.J.; Lazaro, C. (Instituto de Astrofisica de Canarias, La Laguna (Spain))

    1990-03-01

    Infrared J and K light curves of two RS CVn short-period systems, XY UMa and WY Cnc, are presented. Both systems show similar variability in the infrared to that observed in the visual. From the colors an infrared excess is inferred for the primary component of both systems. A new determination of their geometrical elements is presented and the resulting parameters are compared to those previously obtained from visible photometry. The light curves show peculiarities that may indicate the presence of gas streams in the systems. 27 refs.

  5. The shortest modulation period Blazhko RR Lyrae star: SS Cnc

    E-print Network

    J. Jurcsik; B. Szeidl; Á. Sódor; I. Dékány; Zs. Hurta; K. Posztobányi; K. Vida; M. Váradi; A. Szing

    2006-03-20

    Extended BV(RI)c CCD observations of SS Cnc, a short period RRab star are presented. Nearly 1400 data points in each band have been obtained spanning over 79 days during the spring of 2005. The star exhibits light curve modulation, the so called Blazhko effect with small amplitude (B maximum brightness varies 0.1 mag) and with the shortest modulation period (5.309 d) ever observed. In the Fourier spectrum of the V light curve the pulsation frequency components are detected up to the 24th harmonic order, and modulation side lobe frequencies with significantly asymmetric amplitudes are seen up to the 15th and 9th orders for the lower and higher frequency components, respectively. Detailed comparison of the modulation behavior of SS Cnc and RR Gem, the two recently discovered small amplitude, short modulation period Blazhko stars is presented. The modulation frequency (f_m) appears in the Fourier spectrum of both stars with similar amplitude. We also demonstrate that the modulation frequencies have basically different properties as the pulsation and modulation side lobe frequencies have, indicating that the physics behind these frequency components are not the same. The discovery of small amplitude modulations of RRab stars cautions that the large photometric surveys (MACHO, OGLE) may seriously underestimate the number of modulated RR Lyrae stars.

  6. Line blanketed model atmospheres of Ap-stars. V - The Hg-Mn stars 53 Tau and Kappa CNC

    NASA Astrophysics Data System (ADS)

    Stepien, K.; Muthsam, H.

    1981-07-01

    All available observations of the energy distributions of 53 Tau and ? Cnc from the wavelength interval between L? and the Paschen jump are compared with a series of model atmospheres in which temperature, microturbulent velocity and chemical composition were varied. Good agreement is obtained if effective temperatures of 53 Tau and ? Cnc are 11,250 K and 12,800 K, respectively, and the chemical compositions are taken from Strom (1969) and Kodaira (1965). New chemical compositions obtained by Heacox (1979) produce too much blanketing in UV, particularly for ? Cnc. For 53 Tau the set with ?micr = 0 gives equally good fit as the old abundances and the resulting temperature is 11,400 K. Observations of both stars show a slight excess of radiation in the red. It is suggested that this excess may be caused by the circumstellar matter.

  7. Long-term starspot activity of short-period RS Canum Venaticorum stars. IV. WY Cancri

    SciTech Connect

    Zeilik, M.; Cox, D.A.; Ledlow, M.J.; Rhodes, M.; Heckert, P.A. (New Mexico Univ., Albuquerque (USA) U.S. Air Force Academy, Colorado Springs, CO (USA) Western Carolina Univ., Cullowhee, NC (USA))

    1990-11-01

    The photometric distortion waves in the short-period RS CVn system WY CnC are parametrized by a dark, circular spot model for the active regions on the primary star. From recent observations and archival sources, the changes in positions and areas of the active regions are inferred. For light curves with simultaneous visual and red or infrared data, the average temperatures of the spotted regions relative to the photosphere are evaluated. In 1989, it is found that T(spot) = 3970 + or - 300 K for a primary star temperature of 5520 K. Some indication is found of a nonuniform temperature distribution in longitude across the spotted area at this time. The active regions tend to occur at low latitudes, in contrast to the high latitudes previously found for SV Cam, RT And, and BH Vir. It is found again that the active regions fall into preferred longitudes near 90 and 270 deg. 27 refs.

  8. Beryllium abundances in parent stars of extrasolar planets: 16 Cyg A & B and rho 1 Cnc

    E-print Network

    R. J. Garcia Lopez; M. R. Perez de Taoro

    1998-03-03

    The Be II 3131 A doublet has been observed in the solar-type stars 16 Cyg A & B and in the late G-type star rho 1 Cnc, to derive their beryllium abundances. 16 Cyg A & B show similar (solar) beryllium abundances while 16 Cyg B, which has been proposed to have a planetary companion of ~2 M_Jup, is known to be depleted in lithium by a factor larger than 6 with respect to 16 Cyg A. Differences in their rotational histories which could induce different rates of internal mixing of material, and the ingestion of a similar planet by 16 Cyg A are discussed as potential explanations. The existence of two other solar-type stars which are candidates to harbour planetary-mass companions and which show lithium and beryllium abundances close to those of 16 Cyg A, requires a more detailed inspection of the peculiarities of the 16 Cyg system. For rho 1 Cnc, which is the coolest known object candidate to harbour a planetary-mass companion (M > 0.85 M_Jup), we establish a precise upper limit for its beryllium abundance, showing a strong Be depletion which constrains the available mixing mechanisms. Observations of similar stars without companions are required to asses the potential effects of the planetary companion on the observed depletion. It has been recently claimed that rho 1 Cnc appears to be a subgiant. If this were the case, the observed strong Li and Be depletions could be explained by a dilution process taking place during its post-main sequence evolution.

  9. MOA-2010-BLG-523: 'FAILED PLANET' = RS CVn STAR

    SciTech Connect

    Gould, A.; Yee, J. C.; Pinsonneault, M. H.; Dong, Subo; Gaudi, B. S.; Hung, L.-W. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States)] [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Bond, I. A. [Institute for Information and Mathematical Sciences, Massey University, Private Bag 102-904, Auckland 1330 (New Zealand)] [Institute for Information and Mathematical Sciences, Massey University, Private Bag 102-904, Auckland 1330 (New Zealand); Udalski, A. [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland)] [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland); Han, C. [Department of Physics, Chungbuk National University, Cheongju 361-763 (Korea, Republic of)] [Department of Physics, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Jorgensen, U. G. [Niels Bohr Institutet, Kobenhavns Universitet, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark)] [Niels Bohr Institutet, Kobenhavns Universitet, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark); Greenhill, J. [University of Tasmania, School of Mathematics and Physics, Private Bag 37, Hobart, TAS 7001 (Australia)] [University of Tasmania, School of Mathematics and Physics, Private Bag 37, Hobart, TAS 7001 (Australia); Tsapras, Y. [Las Cumbres Observatory Global Telescope Network, 6740B Cortona Dr, Goleta, CA 93117 (United States)] [Las Cumbres Observatory Global Telescope Network, 6740B Cortona Dr, Goleta, CA 93117 (United States); Bensby, T. [Lund Observatory, Department of Astronomy and Theoretical Physics, Box 43, SE-221 00 Lund (Sweden)] [Lund Observatory, Department of Astronomy and Theoretical Physics, Box 43, SE-221 00 Lund (Sweden); Allen, W. [Vintage Lane Observatory, Blenheim (New Zealand)] [Vintage Lane Observatory, Blenheim (New Zealand); Almeida, L. A.; Jablonski, F. [Divisao de Astrofisica, Instituto Nacional de Pesquisas Espaciais, Avenida dos Astronautas, 1758 Sao Jose dos Campos, 12227-010 SP (Brazil)] [Divisao de Astrofisica, Instituto Nacional de Pesquisas Espaciais, Avenida dos Astronautas, 1758 Sao Jose dos Campos, 12227-010 SP (Brazil); Bos, M. [Molehill Astronomical Observatory, North Shore (New Zealand)] [Molehill Astronomical Observatory, North Shore (New Zealand); Christie, G. W. [Auckland Observatory, Auckland (New Zealand)] [Auckland Observatory, Auckland (New Zealand); DePoy, D. L. [Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843-4242 (United States)] [Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843-4242 (United States); Lee, C.-U. [Korea Astronomy and Space Science Institute, 776 Daedukdae-ro, Yuseong-gu, Daejeon 305-348 (Korea, Republic of)] [Korea Astronomy and Space Science Institute, 776 Daedukdae-ro, Yuseong-gu, Daejeon 305-348 (Korea, Republic of); Collaboration: muFUN Collaboration; MOA Collaboration; OGLE Collaboration; MiNDSTEp Consortium; RoboNet Collaboration; PLANET Collaboration; and others

    2013-02-15

    The Galactic bulge source MOA-2010-BLG-523S exhibited short-term deviations from a standard microlensing light curve near the peak of an A {sub max} {approx} 265 high-magnification microlensing event. The deviations originally seemed consistent with expectations for a planetary companion to the principal lens. We combine long-term photometric monitoring with a previously published high-resolution spectrum taken near peak to demonstrate that this is an RS CVn variable, so that planetary microlensing is not required to explain the light-curve deviations. This is the first spectroscopically confirmed RS CVn star discovered in the Galactic bulge.

  10. cnc-11 cnc-5 cnc-4 cnc-3 Cbr-R09B5.12

    E-print Network

    Ewbank, Jonathan

    cnc-1 cnc-11 cnc-5 cnc-4 cnc-3 cnc-2 elegans briggsae remanei R09B5.12 srj-23 Cbr-R09B5.12 Cre-R09B5.12 R09B5.11 Cre-R09B5.11 Cbr-cnc-5.2 Cbr-cnc-5.1 Cbr-cnc-11 Cbr-cnc-4 Cbr-cnc-3 Cbr-cnc-2 Cre-cnc-5.2 Cre-cnc-5.1 Cre-cnc-11 Cre-cnc-4 Cre-cnc-3 Cre-cnc-2 Cre-cnc-1 R09B5.11 NcoI EcoNI cnc-11 cnc-1

  11. Magnetic field topology of the RS CVn star II Pegasi

    NASA Astrophysics Data System (ADS)

    Kochukhov, O.; Mantere, M. J.; Hackman, T.; Ilyin, I.

    2013-02-01

    Context. The dynamo processes in cool active stars generate complex magnetic fields responsible for prominent surface stellar activity and variability at different time scales. For a small number of cool stars magnetic field topologies were reconstructed from the time series of spectropolarimetric observations using the Zeeman Doppler imaging (ZDI) method, often yielding surprising and controversial results. Aims: In this study we follow a long-term evolution of the magnetic field topology of the RS CVn binary star II Peg using a more self-consistent and physically more meaningful modelling approach compared to previous ZDI studies. Methods: We collected high-resolution circular polarisation observations of II Peg using the SOFIN spectropolarimeter at the Nordic Optical Telescope. These data cover 12 epochs spread over 7 years, comprising one of the most comprehensive spectropolarimetric data sets acquired for a cool active star. A multi-line diagnostic technique in combination with a new ZDI code is applied to interpret these observations. Results: We have succeeded in detecting clear magnetic field signatures in average Stokes V profiles for all 12 data sets. These profiles typically have complex shapes and amplitudes of ~10-3 of the unpolarised continuum, corresponding to mean longitudinal fields of 50-100 G. Magnetic inversions using these data reveals evolving magnetic fields with typical local strengths of 0.5-1.0 kG and complex topologies. Despite using a self-consistent magnetic and temperature mapping technique, we do not find a clear correlation between magnetic and temperature features in the ZDI maps. Neither do we confirm the presence of persistent azimuthal field rings found in other RS CVn stars. Reconstruction of the magnetic field topology of II Peg reveals significant evolution of both the surface magnetic field structure and the extended magnetospheric field geometry on the time scale covered by our observations. From 2004 to 2010 the total field energy drastically declined and the field became less axisymmetric. This also coincided with the transition from predominantly poloidal to mainly toroidal field topology. Conclusions: A qualitative comparison of the ZDI maps of II Peg with the prediction of dynamo theory suggests that the magnetic field in this star is produced mainly by the turbulent ?2 dynamo rather than the solar ?? dynamo. Our results do not show a clear active longitude system, nor is there evidence of the presence of an azimuthal dynamo wave. Based on observations obtained with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, at the Spanish Observatorio del Roque de los Muchachos of the Instituto Astrofisica de Canarias.

  12. Spot activity of the RS Canum Venaticorum star ? Geminorum

    NASA Astrophysics Data System (ADS)

    Kajatkari, P.; Hackman, T.; Jetsu, L.; Lehtinen, J.; Henry, G. W.

    2014-02-01

    Aims: We model the photometry of RS CVn star ? Geminorum to obtain new information on the changes of the surface starspot distribution, that is, activity cycles, differential rotation, and active longitudes. Methods: We used the previously published continuous period search (CPS) method to analyse V-band differential photometry obtained between the years 1987 and 2010 with the T3 0.4 m Automated Telescope at the Fairborn Observatory. The CPS method divides data into short subsets and then models the light-curves with Fourier-models of variable orders and provides estimates of the mean magnitude, amplitude, period, and light-curve minima. These light-curve parameters are then analysed for signs of activity cycles, differential rotation and active longitudes. Results: We confirm the presence of two previously found stable active longitudes, synchronised with the orbital period Porb = 19.60d, and found eight events where the active longitudes are disrupted. The epochs of the primary light-curve minima rotate with a shorter period Pmin,1 = 19.47d than the orbital motion. If the variations in the photometric rotation period were to be caused by differential rotation, this would give a differential rotation coefficient of ? ? 0.103. Conclusions: The presence of two slightly different periods of active regions may indicate a superposition of two dynamo modes, one stationary in the orbital frame and the other one propagating in the azimuthal direction. Our estimate of the differential rotation is much higher than previous results. However, simulations show that this may be caused by insufficient sampling in our data. Analysed photometry and numerical results are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/562/A107

  13. Theoretical studies of the RS cannum venaticorum stars

    NASA Technical Reports Server (NTRS)

    Mullan, D. J.

    1981-01-01

    Four areas of research were investigated: chromospheric modelling; starspot modelling; supersonic transition locus (STL) crossing; and STL crossing and T Tauri phenomena. Relationships among these areas of research are presented. Stellar structure and mass ejection for these stars were examined along with chromospheric analysis.

  14. Time Minimization of CNC Part Programs in a Vertical Machining Center in Terms of Tool Path and Cutting Parameter Criteria

    Microsoft Academic Search

    Ahmet Murat PINAR

    An algorithm was prepared for minimizing the machining time of CNC part programs used in a vertical machining center. The CNC program is transferred from the machine to the CNC code editor with a serial cable (RS-232). The time calculator examines all the codes in the code editor and calculates the time of all the moves in minutes. The other

  15. Southern RS CVn systems - Candidate list. [spectral catalog of variable binary stars

    NASA Technical Reports Server (NTRS)

    Weiler, E. J.; Stencel, R. E.

    1979-01-01

    A list of 43 candidate RS CVn binary systems in the far southern hemisphere of the sky (south of -40 deg declination) is presented. The candidate systems were selected from the first two volumes of the Michigan Spectral Catalog (1975, 1978), which provides MK classifications for southern HD stars and identifies any unusual characteristics noted for individual stellar spectra. The selection criteria used were: (1) the occurrence of Ca II H and K emission; (2) known or suspected binary nature; (3) regular light variations of zero to one magnitude; and (4) spectral type between F0 and K2 and luminosity less than bright giant (II).

  16. Long-term starspot activity of short-period RS Canum Venaticorum stars. III - BH Virginis

    SciTech Connect

    Zeilik, M.; Ledlow, M.; Rhodes, M.; Arevalo, M.J.; Budding, E. (New Mexico Univ., Albuquerque (USA) Air Force Academy, Colorado Springs, CO (USA) Instituto de Astrofisica de Canarias, La Laguna (Spain) Carter Observatory, Wellington (New Zealand))

    1990-05-01

    The photometric distortion waves in the light curves of the short-period RS CVn system BH Vir by a dark, circular spot model for the active regions on the primary star is parameterized. Recent observations and archival sources are used to infer the positions and areas of the active regions. For light curves with simultaneous B and R or V and I data, the temperatures of the spotted regions relative to the photospheres can be evaluated. For BH Vir in 1986, T(spot) = 4900 + or - 500 K. The active regions tend to occur at high latitudes and at preferred longitudes near 90 and 270 deg. 32 refs.

  17. CNC Programming I.

    ERIC Educational Resources Information Center

    Casey, Joe

    This document contains five units for a course in computer numerical control (CNC) for computer-aided manufacturing. It is intended to familiarize students with the principles and techniques necessary to create proper CNC programs manually. Each unit consists of an introduction, instructional objectives, learning materials, learning activities,…

  18. Open architecture CNC system

    SciTech Connect

    Tal, J. [Galil Motion Control Inc., Sunnyvale, CA (United States); Lopez, A.; Edwards, J.M. [Los Alamos National Lab., NM (United States)

    1995-04-01

    In this paper, an alternative solution to the traditional CNC machine tool controller has been introduced. Software and hardware modules have been described and their incorporation in a CNC control system has been outlined. This type of CNC machine tool controller demonstrates that technology is accessible and can be readily implemented into an open architecture machine tool controller. Benefit to the user is greater controller flexibility, while being economically achievable. PC based, motion as well as non-motion features will provide flexibility through a Windows environment. Up-grading this type of controller system through software revisions will keep the machine tool in a competitive state with minimal effort. Software and hardware modules are mass produced permitting competitive procurement and incorporation. Open architecture CNC systems provide diagnostics thus enhancing maintainability, and machine tool up-time. A major concern of traditional CNC systems has been operator training time. Training time can be greatly minimized by making use of Windows environment features.

  19. FR Cnc Revisited: Photometry, Polarimetry and Spectroscopy

    E-print Network

    Golovin, A; Hernan-Obispo, M; Andreev, M; Barnes, J R; Montes, D; Pavlenko, E; Pandey, J C; Martinez-Arnaiz, R; Medhi, B J; Parihar, P S; Henden, A; Sergeev, A; Zaitsev, S V; Karpov, N

    2011-01-01

    Here we present the study of FR Cnc, a young, active and spotted star. We performed analysis of ASAS-3 (The All Sky Automated Survey) data for the years 2002-2008 and amended the value of the rotational period to be 0.826518 d. The amplitude of photometric variations decreased abruptly in the year 2005, while the mean brightness remained the same, which was interpreted as a quick redistribution of spots. BVRc and Ic broad band photometric calibration was performed for 166 stars in FR Cnc vicinity. The photometry at Terskol Observatory shows two brightening episodes, one of which occurred at the same phase as the flare of 2006 November 23. Polarimetric BVR observations indicate the probable presence of a supplementary source of polarization. We monitored FR Cnc spectroscopically during the years 2004-2008. We concluded that the RV changes cannot be explained by the binary nature of FR Cnc. We determined the spectral type of FR Cnc as K7V. Calculated galactic space-velocity components (U, V, W) indicate that FR...

  20. Long-term starspot activity of short-period RS Canum Venaticorum stars. II. RT Andromedae

    SciTech Connect

    Zeilik, M.; Cox, D.A.; De Blasi, C.; Rhodes, M.; Budding, E. (New Mexico Univ., Albuquerque (USA) Carter Observatory, Wellington (New Zealand))

    1989-10-01

    The photometric distortion waves in the light curves of the short-period RS CVn system RT And are parameterized by means of a dark, circular starspot model. The light curves are drawn from archival sources and 1987 and 1989 observations. The longitudes, latitudes, and areas of the active regions are inferred and the information content of the archival data is evaluated. It is concluded that one large starspot region on the primary star at high latitude and near quadrature longitudes can account for the major maculation effects since 1920. The temperature difference between the spotted region and the photosphere is 1100 to 1200 K. Good quality light curves result in an eccentricity (e = 0.026) and major axis orientation consistent with those reported by others using different procedures. 36 refs.

  1. CAD/CAM/CNC.

    ERIC Educational Resources Information Center

    Domermuth, Dave; And Others

    1996-01-01

    Includes "Quick Start CNC (computer numerical control) with a Vacuum Filter and Laminated Plastic" (Domermuth); "School and Industry Cooperate for Mutual Benefit" (Buckler); and "CAD (computer-assisted drafting) Careers--What Professionals Have to Say" (Skinner). (JOW)

  2. The dusty AGB star RS CrB: first mid-infrared interferometric observations with the Keck telescopes

    NASA Technical Reports Server (NTRS)

    Mennesson, B.; Koresko, C.; Creech-Eakman, M. J.; Serabyn, E.; Colavita, M. M; Akeson, R.; Appleby, E.; Bell, J.; Booth, A.; Crawford, S.; Dahl, W.; Fanson, J.; Felizardo, C.; Garcia, J.; Gathright, J.; Herstein, J.; Hovland, E.; Hrynevych, M.; Johansson, E.; Le Mignant, D.; Ligon, R.; Millan-Gabet, R.; Moore, J.; Neyman, C.; Palmer, D.

    2005-01-01

    We report interferometric observations of the semiregular variable star RS CrB, a red giant with strong silicate emission features. The data were among the first long-baseline mid-infrared stellar fringes obtained between the Keck telescopes, using parts of the new nulling beam combiner.

  3. S 10947 Aql = RX J2009.8+1557: A probable RS CVn star which sometimes stops its eclipses

    E-print Network

    G. A. Richter; J. Greiner

    2000-08-25

    We report the discovery of a new variable star, called S 10947 Aql, as the likely optical counterpart of RX J2009.8+1557. The optical variability pattern as well as the detected X-ray emission suggest that it is a chromospherically active binary of the RS Canum Venaticorum type. We discovered an occasional disappearance of the eclipsing minima as well as large variations in the eclipse amplitude. We discuss possible causes of this peculiarity.

  4. Unusually Increased Activity of GZ Cnc

    E-print Network

    T. Kato; P. A. Dubovsky; R. Stubbings; M. Simonsen

    2002-07-23

    GZ Cnc was discovered as a variable star by Takamizawa (Tmz V34), which turned out to a cataclysmic variable (CV). Past studies have shown that this object is a good candidate for a rarely outbursting, long-period dwarf nova. Only three outbursts were recorded between 1999 and 2001. In 2002 March-May, the object suddenly showed a dramatic increase of the outburst frequency. The shortest observed interval was only 11 d. We suggest that the present behavior may be interpreted as a clustering of short outbursts occasionally seen in intermediate polars (magnetic CVs). The present activity can also be comparable to V426 Oph, another dwarf nova which is known to show occasionally increased activities. The resemblances in the X-ray properties and the outburst behavior suggests that GZ Cnc and V426 Oph may comprise a new class of (weakly magnetic) cataclysmic variables.

  5. Two New EW-type Eclipsing Variables Near AK Cnc

    Microsoft Academic Search

    Natalia A. Virnina

    2011-01-01

    Two new eclipsing variable stars, USNO-B1.0 1015-0165372 = 2MASS 08543896+1133002 and USNO-B1.0 1017-0168554 = 2MASS 08534894+1143534, were discovered in the field of the cataclysmic variable star AK Cnc. The remotely controlled astrophysical refractor AP-180 of the Tzec Maun Observatory (USA) has been used. Both binary systems were classified as EW-type. All parameters needed for the General Catalog of Variable Stars

  6. Characterization of the Transiting Super-Earth 55 Cnc e

    NASA Astrophysics Data System (ADS)

    Demory, Brice-Olivier; Gillon, M.; Deming, D.; Seager, S.

    2011-09-01

    The transiting nature of 55 Cnc e has been recently unveiled independently by the MOST satellite in the visible (Winn et al. 2011) and Warm Spitzer in the infrared (Demory et al. 2011). 55 Cnc e is the only transiting super-Earth orbiting a naked eye star, which makes this planet a true Rosetta stone in the field of low-mass exoplanets. We will present new follow-up observations scheduled during Summer 2011 that will provide better constraints on the internal structure and immediate environment of this intriguing super-Earth.

  7. QY Cas und EF Cnc - zwei besondere RRc-Sterne

    NASA Astrophysics Data System (ADS)

    Maintz, Gisela

    2013-02-01

    CCD observations of QY Cas (RA = 23:59:05.15, DE = +54:01:00.70) and EF Cnc (RA = 08:40:38.82, DE = 23:15:50.3) were obtained at my private observatory. For QY Cas 9 maxima were gained showing a light curve that varies from epoch to epoch, showing either one broad maximum or double-maxima. Revised elements are given as: QY Cas, Max = 2455887.368 + 0.2741261 *E. For EF Cnc 6 maxima were observed over a time span of 4 years. This long time helped to revise its period to: EF Cnc Max = 2456001.4818 + 0.295778 *E. For several RRc stars having a broad maximum or double-maxima the width of the bright light is found to be about 1/7 of their period.

  8. Towards CNC Programming Using Haskell

    Microsoft Academic Search

    Gustavo Arroyo; Claudio Ochoa; Josep Silva; Germán Vidal

    2004-01-01

    Recent advances in Computerized Numeric Control (CNC) have allowed the manufacturing of products with high quality standards. Since CNC programs consist of a series of assembler-like instructions, several high-level languages (e.g., AutoLISP, APL, OMAC) have been proposed to raise the programming abstraction level. Unfortunately, the lack of a clean semantics prevents the development of formal tools for the analysis and

  9. FR Cnc Nature Revisited M.C. Glvez1, 2 , A. Golovin3, 4, M. Hernn-Obispo2, E. Pavlenko5, M. Andreev6, M., D. Montes2,

    E-print Network

    Complutense de Madrid, Universidad

    FR Cnc Nature Revisited M.C. Gálvez1, 2 , A. Golovin3, 4, M. Hernán-Obispo2, E. Pavlenko5, M. Saraswati, Hanle, INDIA The results of photometric and spectroscopic monitoring of FR Cnc reported a tricky@astrax.fis.ucm.es FR Cnc is a K5-7V, chromospherically active star. Here we found spectroscopic and photometric

  10. CNC Preparation Meets Manufacturing Opportunity

    ERIC Educational Resources Information Center

    Cassola, Joel

    2006-01-01

    This article features the machining technology program at Cape Fear Community College (CFCC) of Wilmington, North Carolina. North Carolina's Cape Fear Community College is working to meet diverse industry needs through its CNC training. The school's program has gained the attention of the local manufacturing community and students when it shifted…

  11. Intelligent process-planning system or optimal CNC programming – a step towards complete automation of CNC programming

    Microsoft Academic Search

    Millan K. Yeung

    2003-01-01

    One of the bottle-necks of computer numerical control (CNC) machining is the CNC programming. It relies on the experience and skills of the CNC programmer for the generation of the CNC program. The intelligent process-planning system described in this paper generates a process plan automatically for CNC programming. It utilizes artificial intelligent technologies such as knowledge base, blackboard system and

  12. CNC electrical discharge machining centers

    SciTech Connect

    Jaggars, S.R.

    1991-10-01

    Computer numerical control (CNC) electrical discharge machining (EDM) centers were investigated to evaluate the application and cost effectiveness of establishing this capability at Allied-Signal Inc., Kansas City Division (KCD). In line with this investigation, metal samples were designed, prepared, and machined on an existing 15-year-old EDM machine and on two current technology CNC EDM machining centers at outside vendors. The results were recorded and evaluated. The study revealed that CNC EDM centers are a capability that should be established at KCD. From the information gained, a machine specification was written and a shop was purchased and installed in the Engineering Shop. The older machine was exchanged for a new model. Additional machines were installed in the Tool Design and Fabrication and Precision Microfinishing departments. The Engineering Shop machine will be principally used for the following purposes: producing deep cavities in small corner radii, machining simulated casting models, machining difficult-to-machine materials, and polishing difficult-to-hand polish mold cavities. 2 refs., 18 figs., 3 tabs.

  13. Rossiter-McLaughlin Observations of 55 Cnc e

    E-print Network

    Lopez-Morales, Mercedes; Rodler, Florian; Dumusque, Xavier; Buchhave, Lars A; Harutyunyan, A; Hoyer, Sergio; Alonso, Roi; Gillon, Michael; Kaib, Nathan A; Latham, David W; Lovis, Christophe; Pepe, Francesco; Queloz, Didier; Raymond, Sean N; Segransan, Damien; Waldmann, Ingo P; Udry, Stephane

    2014-01-01

    We present Rossiter-McLaughlin observations of the transiting super-Earth 55 Cnc e collected during six transit events between January 2012 and November 2013 with HARPS and HARPS-N. We detect no radial-velocity signal above 35 cm/s (3-sigma) and confine the stellar v sin i to 0.2 +/- 0.5 km/s. The star appears to be a very slow rotator, producing a very low amplitude Rossiter-McLaughlin effect. Given such a low amplitude, the Rossiter-McLaughlin effect of 55 Cnc e is undetected in our data, and any spin-orbit angle of the system remains possible. We also performed Doppler tomography and reach a similar conclusion. Our results offer a glimpse of the capacity of future instrumentation to study low amplitude Rossiter-McLaughlin effects produced by super-Earths.

  14. Space curve interpolation for CNC machines

    Microsoft Academic Search

    Sotiris L. Omirou

    2003-01-01

    Despite the tremendous development in CNC programming facilities, linear and circular cuts parallel to the coordinate planes continue to be the standard motions of modern CNC machines. However, the increasing industrial demand for parts with intricate shapes cannot be satisfied with only these standard motions. This paper proposes an efficient and accurate method for developing a class of precise interpolation

  15. An RTOS-based embedded CNC system

    Microsoft Academic Search

    Tao Wang; Qingjian Liu; Liwen Wang

    2010-01-01

    The characteristics of real time operating system (RTOS) are analyzed and its advantages in design of embedded computer numerical control system (CNC system) are highlighted, according to comparisons with general operating systems. In this study, RTOS ?C\\/OS - II is introduced in the embedded hardware platform of CNC system based on ARM and Motion Control Chip. Furthermore, the software architecture

  16. Parametric CNC programming of reconfigurable machine tools based on remanufacturing

    Microsoft Academic Search

    Jian-cheng Zhang; Xin Jin; Lin-hui Zhao; Shao-hua Zhang; Jing-ya Ma

    2011-01-01

    Because of the particularity of its techniques, the remanufacturing parts and ordinary parts are very different from their machining and program method. Due to the CNC software of reconfigurable machine tools is expandable, the parametric CNC programming method is researched. Parametric CNC programming modules is sorted based on typical parts and machining techniques, which is used on CNC system of

  17. Research on Component Technology for Reconfigurable CNC System

    Microsoft Academic Search

    Shaohua Du; Dong Yu

    2009-01-01

    Reconfigurable CNC system, as an extension of open CNC system, can be rapid designed, easy to integrate new technologies and flexible to fulfill different application requirements. In order to implement the reconfigurable CNC system, component based software engineering appears to be an efficient approach. This paper presents a component model for reconfigurable CNC system, which addresses the special functional and

  18. EXPERIENCES IN NEW CNC LEARNING INNOVATIONS MARAVELAKIS Emmanuel1

    E-print Network

    Aristomenis, Antoniadis

    EXPERIENCES IN NEW CNC LEARNING INNOVATIONS MARAVELAKIS Emmanuel1 , YALDIZ Süleyman2 , SAHIN Mehmet learning innovations in CNC training. The evolution of CNC machine technology and continuous developments in CNC programming, produce an increasing demand for an effective, user-friendly and innovative training

  19. TX Cnc AS A MEMBER OF THE PRAESEPE OPEN CLUSTER

    SciTech Connect

    Zhang, X. B.; Deng, L.; Lu, P. [National Astronomical Observatories, Chinese Academy of Sciences, 20A Datun Road, 100012 Beijing (China)

    2009-08-15

    We present B-, V-, and I-band CCD photometry of the W UMa-type binary system TX Cnc, which is a member star of the Praesepe open cluster. Based on the observations, new ephemeris and a revised photometric solution of the binary system were derived. Combined with the results of the radial velocity solution contributed by Pribulla et al., the absolute parameters of the system were determined. The mass, radius, and luminosity of the primary component are derived to be 1.35 {+-} 0.02 M {sub sun}, 1.27 {+-} 0.04 R {sub sun}, and 2.13 {+-} 0.11 L {sub sun}. Those for the secondary star are computed as 0.61 {+-} 0.01 M {sub sun}, 0.89 {+-} 0.03 R {sub sun}, and 1.26 {+-} 0.07 L {sub sun}, respectively. Based on these results, a distance modulus of (m - M) {sub V} = 6.34 {+-} 0.05 is determined for the star. It confirms the membership of TX Cnc to the Praesepe open cluster. The evolutionary status and the physical nature of the binary system are discussed compared with the theoretical model.

  20. The Orbital Architecture of 55 Cnc: An Orbital Resonance, Jupiter Analog, and Transiting Super-Earth

    NASA Astrophysics Data System (ADS)

    Nelson, Benjamin E.; Payne, M.; Ford, E.; Wright, J.

    2011-09-01

    55 Cnc is the only naked eye star with a known transiting planet (Winn et al. 2011) and one of a few systems with five known planets characterized via Doppler methods. The planets span a wide range of masses and orbital periods. We investigate the orbital architecture, focusing on two of the giant planets near 3:1 mean-motion resonance and the potential impact on the dynamical effects on the other planets. To quantify the uncertainty in the orbital parameters of the 55 Cnc system requires exploring a high-dimensional ( 35) parameter space and using self-consistent N-body integrations, both of which are computationally demanding. To surmount these challenges, we apply a differential evolution Markov chain Monte Carlo algorithm to characterize the orbital properties and masses. We present these results and discuss the implications on the dynamical evolution of the 55 Cnc system.

  1. Improving Energy Efficiency in CNC Machining

    NASA Astrophysics Data System (ADS)

    Pavanaskar, Sushrut S.

    We present our work on analyzing and improving the energy efficiency of multi-axis CNC milling process. Due to the differences in energy consumption behavior, we treat 3- and 5-axis CNC machines separately in our work. For 3-axis CNC machines, we first propose an energy model that estimates the energy requirement for machining a component on a specified 3-axis CNC milling machine. Our model makes machine-specific predictions of energy requirements while also considering the geometric aspects of the machining toolpath. Our model - and the associated software tool - facilitate direct comparison of various alternative toolpath strategies based on their energy-consumption performance. Further, we identify key factors in toolpath planning that affect energy consumption in CNC machining. We then use this knowledge to propose and demonstrate a novel toolpath planning strategy that may be used to generate new toolpaths that are inherently energy-efficient, inspired by research on digital micrography -- a form of computational art. For 5-axis CNC machines, the process planning problem consists of several sub-problems that researchers have traditionally solved separately to obtain an approximate solution. After illustrating the need to solve all sub-problems simultaneously for a truly optimal solution, we propose a unified formulation based on configuration space theory. We apply our formulation to solve a problem variant that retains key characteristics of the full problem but has lower dimensionality, allowing visualization in 2D. Given the complexity of the full 5-axis toolpath planning problem, our unified formulation represents an important step towards obtaining a truly optimal solution. With this work on the two types of CNC machines, we demonstrate that without changing the current infrastructure or business practices, machine-specific, geometry-based, customized toolpath planning can save energy in CNC machining.

  2. BD Andromedae: A New Short-period RS CVn Eclipsing Binary Star with a Distant Tertiary Body in a Highly Eccentric Orbit

    NASA Astrophysics Data System (ADS)

    Kim, Chun-Hwey; Song, Mi-Hwa; Yoon, Jo-Na; Han, Wonyong; Jeong, Min-Ji

    2014-06-01

    A photometric study of BD And was made through the analysis of two sets of new BVR light curves. The light curves with migrating photometric waves outside eclipse show that BD And is a short-period RS CVn-type binary star. The analysis of all available timings reveals that the orbital period has varied in a strictly cyclical way with a period of 9.2 yr. The periodic variation most likely arises from the light-time effect due to a tertiary moving in a highly elliptical orbit (e 3 = 0.76). The Applegate mechanism could not operate properly in the eclipsing pair. The light curves were modeled with two large spots on the hotter star and a large third light amounting to about 14% of the total systemic light. BD And is a triple system: a detached binary system consisting of two nearly equal solar-type stars with an active primary star and a G6-G7 tertiary dwarf. The absolute dimensions of the eclipsing pair and tertiary components were determined. The three components with a mean age of about 5.8 Gyr are located at midpositions in main-sequence bands. The radius of the secondary is about 17% larger than that deduced from stellar models. The orbital and radiometric characteristics of the tertiary are intensively investigated. One important feature is that the mutual inclination between two orbits is larger than 60°, implying that Kozai cycles had occurred very efficiently in the past. The possible past and future evolutions of the BD And system, driven by KCTF and MBTF, are also discussed.

  3. BD Andromedae: A new short-period RS CVn eclipsing binary star with a distant tertiary body in a highly eccentric orbit

    SciTech Connect

    Kim, Chun-Hwey; Song, Mi-Hwa; Yoon, Jo-Na; Jeong, Min-Ji [Department of Astronomy and Space Science, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Han, Wonyong, E-mail: kimch@chungbuk.ac.kr [Korea Astronomy and Space Institute, Daejeon 305-348 (Korea, Republic of)

    2014-06-20

    A photometric study of BD And was made through the analysis of two sets of new BVR light curves. The light curves with migrating photometric waves outside eclipse show that BD And is a short-period RS CVn-type binary star. The analysis of all available timings reveals that the orbital period has varied in a strictly cyclical way with a period of 9.2 yr. The periodic variation most likely arises from the light-time effect due to a tertiary moving in a highly elliptical orbit (e {sub 3} = 0.76). The Applegate mechanism could not operate properly in the eclipsing pair. The light curves were modeled with two large spots on the hotter star and a large third light amounting to about 14% of the total systemic light. BD And is a triple system: a detached binary system consisting of two nearly equal solar-type stars with an active primary star and a G6-G7 tertiary dwarf. The absolute dimensions of the eclipsing pair and tertiary components were determined. The three components with a mean age of about 5.8 Gyr are located at midpositions in main-sequence bands. The radius of the secondary is about 17% larger than that deduced from stellar models. The orbital and radiometric characteristics of the tertiary are intensively investigated. One important feature is that the mutual inclination between two orbits is larger than 60°, implying that Kozai cycles had occurred very efficiently in the past. The possible past and future evolutions of the BD And system, driven by KCTF and MBTF, are also discussed.

  4. A parametric programming technique for efficient CNC machining operations

    Microsoft Academic Search

    Manocher Djassemi

    1998-01-01

    In this paper the application of parametric programming to CNC machining is discussed. As one of the less frequently utilized features of CNC machines, parametric programming has the potential to increase the efficiency of CNC operations. This feature is particularly beneficial to companies with group technology manufacturing where parts with similar design or operational requirements are processed within a machine

  5. Towards CNC Programming Using Haskell , C. Ochoa2

    E-print Network

    Vidal, Germán

    Towards CNC Programming Using Haskell G. Arroyo1 , C. Ochoa2 , J. Silva2 , and G. Vidal2 1 CIIDET,jsilva,gvidal}@dsic.upv.es Abstract. Recent advances in Computerized Numeric Control (CNC) have allowed the manufacturing of products with high quality standards. Since CNC programs consist of a series of assembler-like instructions, several

  6. Posted 4/19/12 CNC Instructor Job Announcement

    E-print Network

    Heller, Barbara

    Posted 4/19/12 CNC Instructor Job Announcement About the Position: Reporting to the Career & Community Program Director of the Center for Labor & Community Research (CLCR), the CNC Instructor be available based on demand. CLCR offers competitive wages and generous benefits as eligible. The CNC

  7. The CnC Programmimg Model Zoran Budimlic1

    E-print Network

    Palsberg, Jens

    The CnC Programmimg Model Zoran Budimli´c1 Michael Burke1 Vincent Cav´e1 Kathleen Knobe2 Geoff Rice University 2 Intel Corporation 3 UCLA Abstract We introduce the Concurrent Collections (CnC) programming model. CnC supports flexible combinations of task and data parallelism while retaining determinism

  8. Spectroscopic Analyses of the Planetary System Candidates: 55 Cnc, 51 Peg, 47 UMa, 70 Vir, and HD 114762

    E-print Network

    Guillermo Gonzalez

    1996-09-20

    The stars 55 Cnc, 51 Peg, 47 UMa, 70 Vir, and HD 114762 have recently been proposed to harbor planetary mass companions. Using spectrospic methods we find that 55 Cnc and 51 Peg are super metal- rich, 47 UMa and 70 Vir have roughly solar metallicities, and HD 114762 is metal-poor. Otherwise, the abundance patterns, expressed as [X/Fe], are approximately solar. The ages of 47 UMa and 51 Peg are similar to that of the Sun; 70 Vir is slightly older, and 55 Cnc and HD 114762 are at least 10 Gyr old. Our estimates of vsini for the parent stars are 1.4, 1.8, 2.0, Cnc, 51 Peg, 47 UMa, 70 Vir, and HD 114762, respectively. Using these data and estimates for the rotation periods and radii, the corresponding masses of the companions are: > 0.6, 0.51, 4.6, > 20, and > 8.5 MJ. The systems appear to fall into three groups: roughly Jupiter mass companions with small circular orbits with metal-rich parent stars (55 Cnc and 51 Peg), larger companions with larger circular orbits (47 UMa), and much more massive companions with large eccentric orbits around moderately metal- poor parent stars (70 Vir and HD 114762). Our findings are consistent with the recently proposed mechanism whereby a gas giant migrates to within a few hundredths of an AU of its parent star during the formative epoch of the planetary system. During this process the material between the giant planet and the star is accreted onto the latter. If the accreted material is depleted in H and He, then the photospheric composition of the parent star might be altered significantly.

  9. Chromospherically active stars. III - HD 26337 = EI Eri: An RS CVn candidate for the Doppler-imaging technique

    NASA Technical Reports Server (NTRS)

    Fekel, Francis C.; Quigley, Robert; Gillies, Kim; Africano, John L.

    1987-01-01

    Spectroscopic observations of the chromospherically active G5 IV single-lined binary HD 26337 = EI Eri are presented. An orbital period of 1.94722 days is found for the star. It has moderately strong Ca II H and K emission and strong ultraviolet emission features, while H-alpha is a weak absorption feature that is variable in strength. The inclination of the system is 46 + or - 12 deg, and the unseen secondary is probably a late K or early M dwarf. The v sin i of the primary is 50 + or - 3 km/s, resulting in a minimum radius of 1.9 + or - 0.1 solar radius. The star is within the required limits for Doppler imaging. The primary is close to filling its Roche lobe, resulting in a strong constraint that the mass ratio is 2.6 or greater, with a primary mass of at least 1.4 solar mass. The distance to the system is estimated at 75 pc.

  10. Development of Lathe Attachment for a CNC Machine

    NASA Astrophysics Data System (ADS)

    Roy, V.; Kumar, S.

    2013-04-01

    A lathe attachment has been developed for an existing CNC machine (installed with rapid prototyping attachment) using conceptual design. The CNC machine operates on mechatronic controls and a computer interface called CAMSOFT, and is used as a CNC Lathe after installing the respective attachment to it. The conceptual design phase, starts from an idea and different components of the lathe are designed as attachment using CAD modelling and is followed by fabrication phase. The lathe attachment is successfully developed and is installed to the CNC machine. The working of the CNC Lathe attachment is checked by making some machining operation like turning and thread cutting. The machining operations are successfully done. The CNC machine becomes multifunctional with the presently developed lathe attachment and the existing RP (rapid prototyping) attachment, and can be used accordingly by installing the respective attachment to it. The CNC machine is useful for carrying research work in both the fields, when installed with the appropriate attachment.

  11. Predicitve Monitoring Environment for CNC Machining

    Microsoft Academic Search

    M. Martins-Barbara; J. M. Ribeiro-Fonseca; A. Steiger-Garcao

    1990-01-01

    This paper presents and discusses a proposal for an open architecture for CNC program generation, esecution and predictive monitoring, incorporating also the information system concept as a support and interface to the FMS as a whole. A reference model is presented, associated with specific discussion of an already implemented transputer supported solution. A knowledge based approach aimed to support modelling

  12. PROGRAMING CNC MEASURING MACHINES BY GENETIC ALGORITHMS

    Microsoft Academic Search

    Miran Brezocnik; Miha Kovacic; Joze Balic; Bogdan Sovilj

    2004-01-01

    The need for efficient and reliable tools for programming of CNC coordinate measuring machine is rapidly increasing in modern production. The proposed concept based on genetic algorithms assures generation and optimization of NC programs for measuring machine. Therefore the structure, undergoing simulated evolution, is the population of NC programs. The NC programs control the tactile probe which performs simple elementary

  13. PRE-MACHINING CNC CONTOUR VALIDATION

    Microsoft Academic Search

    Tony Schmitz; John Ziegert

    The current procedure followed to manufacture a new part by CNC machining is to write the part program, machine a test part and measure the test part for conformance to the required dimensions and tolerances. If the test part dimensions are not correct, the part program is modified and the process repeated until a successful part is machined. In many

  14. The Maryland CNC Test: normative studies.

    PubMed

    Causey, G D; Hood, L J; Hermanson, C L; Bowling, L S

    1984-01-01

    These studies were conducted to determine the performance-intensity functions of the Maryland CNC Test (male voice) with normal-hearing and hearing-impaired persons, to examine the equivalence of the 10 lists, and to determine test-retest reliability. There was a 2.1% increase per decibel in word recognition in the linear portion of the performance-intensity function for normal listeners and a 1.3% increase per decibel for hearing-impaired listeners. 6 lists were judged to be equivalent, and there was good test-retest reliability. Hearing-impaired subjects demonstrated a wide range of scores on the Maryland CNC Test, suggesting that this measure can distinguish among varying degrees of word recognition ability. PMID:6517748

  15. Developing an integrated STEP-compliant CNC prototype

    Microsoft Academic Search

    S. H Suh; D. H Chung; B. E Lee; J. H Cho; S. U Cheon; H. D Hong; H. S Lee

    2002-01-01

    STEP-compliant CNC is the next-generation CNC controller, taking the STEP-NC data model as the interface scheme between CAM and CNC and carrying out various intelligent functions. At the moment, efforts are being made worldwide to establish an international standard for the new interface scheme (so-called STEP-NC), formalized as ISO 14649. In the near future, the new interface scheme will be

  16. Planetpol polarimetry of the exoplanet systems 55 Cnc and tau Boo

    E-print Network

    P. W. Lucas; J. H. Hough; J. A. Bailey; M. Tamura; E. Hirst; D. Harrison

    2008-11-04

    We present very sensitive polarimetry of 55 Cnc and tau Boo in an attempt to detect the partially polarised reflected light from the planets orbiting these two stars. 55 Cnc is orbited by a hot Neptune planet (55 Cnc e) at 0.038 AU, a hot Jupiter planet (55 Cnc b) at 0.11 AU, and at least 3 more distant planets. The polarisation of this system is very stable, showing no sign of the periodic variations that would be expected if a short period planet were detected. The measured standard deviation of the night averaged Stokes Q/I and U/I parameters is 2.2x10^{-6}. We derive upper limits on the geometric albedo, A_G and planetary radius using Monte Carlo multiple scattering simulations of a simple model atmosphere. We assume Rayleigh-like scattering (scaled by the maximum polarisation, p_m at 90 degrees) and pressure insensitive extinction. Atmospheres in which multiple scattering plays only a small role have an almost linear relation between polarisation and A_G. In this case, the 4 sigma upper limits is A_GCnc e. This suggests that 55 Cnc e is relatively small and not a pure H-He planet. The data do not give a useful upper limit for 55 Cnc b. tau Boo is orbited by an unusually massive hot Jupiter planet. The standard deviation in the night averaged Stokes Q/I and U/I polarisation parameters is 5.1x10^{-6}. The 4 sigma upper limit is A_G<0.37(R/1.2 R_{Jup})^{-2}p_m^{-1} for tau Boo b. This extends the similar upper limits reported previously for this planet to longer wavelengths. The larger scatter in the tau Boo data may be due to the spot activity detected photometrically by the MOST satellite. These results contrast markedly with the recent claim of a 3 sigma detection of a periodic polarisation signal from HD189733 with amplitude P=2x10^{-4}, attributed to the planet HD189733 b.

  17. CNC Turning Technician. A Competency-Based Instructional System.

    ERIC Educational Resources Information Center

    Sloan, Kelly; Hilley, Robert

    This competency-based curriculum guide for instructing students in using computer numerically controlled (CNC) turning machines is one of a series of instructional guides for the machinist field developed in Oklahoma. Although developed jointly with Baxter Technologies Corporation and oriented toward the Baxter Vo-Tec 2000 Future Builder CNC

  18. Advanced CNC Programming (EZ-CAM). 439-366.

    ERIC Educational Resources Information Center

    Casey, Joe

    This document contains two units for an advanced course in computer numerical control (CNC) for computer-aided manufacturing. It is intended to familiarize students with the principles and techniques necessary to create proper CNC programs using computer software. Each unit consists of an introduction, instructional objectives, learning materials,…

  19. Strategic advantages of interoperability for global manufacturing using CNC technology

    Microsoft Academic Search

    S. T. Newman; A. Nassehi; X. W. Xu; R. S. U. Rosso; L. Wang; Y. Yusof; L. Ali; R. Liu; L. Y. Zheng; S. Kumar; P. Vichare; V. Dhokia

    2008-01-01

    In the domain of manufacturing, computer numerically controllers (CNC) technology is a major contributor to the production capacity of the enterprises. The advances in CNC technology coupled with enhancements in computing systems have provided the basis to re-examine the way in which computer-aided systems (CAx) can be used to enable global manufacturing. Interoperability of the various components of the CAx

  20. Understanding and Writing G & M Code for CNC Machines

    ERIC Educational Resources Information Center

    Loveland, Thomas

    2012-01-01

    In modern CAD and CAM manufacturing companies, engineers design parts for machines and consumable goods. Many of these parts are cut on CNC machines. Whether using a CNC lathe, milling machine, or router, the ideas and designs of engineers must be translated into a machine-readable form called G & M Code that can be used to cut parts to precise…

  1. ULTRACAM photometry of the eclipsing cataclysmic variables GY Cnc, IR Com and HT Cas

    E-print Network

    W. J. Feline; V. S. Dhillon; T. R. Marsh; C. A. Watson; S. P. Littlefair

    2005-10-14

    We present high-speed, three-colour photometry of the eclipsing cataclysmic variables GY Cnc, IR Com and HT Cas. We find that the sharp eclipses in GY Cnc and IR Com are due to eclipses of the white dwarf. There is some evidence for a bright spot on the edge of the accretion disc in GY Cnc, but not in IR Com. Eclipse mapping of HT Cas is presented which shows changes in the structure of the quiescent accretion disc. Observations in 2002 show the accretion disc to be invisible except for the presence of a bright spot at the disc edge. 2003 observations, however, clearly show a bright inner disc and the bright spot to be much fainter than in 2002. Although no outburst was associated with either set of quiescent observations, the system was ~0.6 mJy brighter in 2003, mainly due to the enhanced emission from the inner disc. We propose that these changes are due to variations in the mass transfer rate from the secondary star and through the disc. The disc colours indicate that it is optically thin in both its inner and outer regions. We estimate the white dwarf temperature of HT Cas to be 15 000 +/- 1000 K in 2002 and 14 000 +/- 1000 K in 2003.

  2. Virtual Training Centre For CNC: a Sample Virtual Training Environment Mehmet Sahin1

    E-print Network

    Aristomenis, Antoniadis

    Virtual Training Centre For CNC: a Sample Virtual Training Environment Mehmet Sahin1 , Süleyman and reinforce Vocational Training in Computer Numerical Control (CNC) Machines. "Virtual Training Centre for CNC over other training tools in VET. Keywords: Virtual training center, CNC, Training centre 1

  3. Study of Accuracy of CNC Machine Tools

    NSDL National Science Digital Library

    Chattopadhyay, Sonnath

    The dimensional accuracies as well as surface finishes of parts produced by a CNC machine tool are strongly dependent on the motion accuracy of each axis of the machine. The overall accuracy of the machine tool is decided by the mechanical characteristics of the machine as well as the characteristics if the control system driving the individual axes. A CNC Machine is programmed to travel along a predetermined or contour, and any deviation from the programmed path is referred as the contouring error. A typical test that is used is a circular test in which the machine is programmed to travel along a circle, and the difference between the programmed path and the measured actual path is compared. The purpose of this study is to identify the various contributors to this contouring error, and in particular estimate the error due to stick slip motion using analytical techniques. It is planned to measure the errors experimentally making use of capacitance probes. The study is intended to develop an appreciation for the sources of different errors produced in a machine tool and as such forms a module in a typical semester long class devoted to manufacturing processes.

  4. Very low luminosity stars with very large amplitude flares

    SciTech Connect

    Schaefer, B.E. (NASA, Goddard Space Flight Center, Greenbelt, MD (USA))

    1990-04-01

    CCD frames of CZ Cnc, KY Cep, the gamma-ray burster optical transient, and NSV 12006 are analyzed. Also studied are 549 archival photographic plates of the CZ Cnc field. These observations are compared with the data of Lovas (1976). Flare events on CZ Cnc are examined. Based on the data it is noted that CZ Cnc is a main-sequence star, has a magnitude of 16.1, a distance of 100 pc, occasional large-amplitude flares, and frequent flares with amplitudes greater than 4 mag. 36 refs.

  5. Very low luminosity stars with very large amplitude flares

    NASA Technical Reports Server (NTRS)

    Schaefer, Bradley E.

    1990-01-01

    CCD frames of CZ Cnc, KY Cep, the gamma-ray burster optical transient, and NSV 12006 are analyzed. Also studied are 549 archival photographic plates of the CZ Cnc field. These observations are compared with the data of Lovas (1976). Flare events on CZ Cnc are examined. Based on the data it is noted that CZ Cnc is a main-sequence star, has a magnitude of 16.1, a distance of 100 pc, occasional large-amplitude flares, and frequent flares with amplitudes greater than 4 mag.

  6. Close binary stars in the solar-age Galactic open cluster M67

    E-print Network

    Yakut, K; Kalomeni, B; Van Winckel, H; Waelkens, C; De Cat, P; Bauwens, E; Vuckovic, M; Saesen, S; Guillou, L Le; Parmaksizoglu, M; Uluc, K; Khamitov, I; Raskin, G; Aerts, C

    2009-01-01

    We present multi-colour time-series CCD photometry of the solar-age galactic open cluster M67 (NGC 2682). About 3600 frames spread over 28 nights were obtained with the 1.5 m Russian-Turkish and 1.2 m Mercator telescopes. High-precision observations of the close binary stars AH Cnc, EV Cnc, ES Cnc, the $\\delta$ Scuti type systems EX Cnc and EW Cnc, and some long-period variables belonging to M67 are presented. Three full multi-colour light curves of the overcontact binary AH Cnc were obtained during three observing seasons. Likewise we gathered three light curves of EV Cnc, an EB-type binary, and two light curves of ES Cnc, a blue straggler binary. Parts of the light change of long-term variables S1024, S1040, S1045, S1063, S1242, and S1264 are obtained. Period variation analysis of AH Cnc, EV Cnc, and ES Cnc were done using all times of mid-eclipse available in the literature and those obtained in this study. In addition, we analyzed multi-colour light curves of the close binaries and also determined new fre...

  7. 1CIE/USA-CNC/CIE 2013 CIE/USA-CNC/CIE Biennial Joint Meeting, Davis, CA, Nov. 7-8, 2013

    E-print Network

    California at Davis, University of

    1CIE/USA-CNC/CIE 2013 CIE/USA-CNC/CIE Biennial Joint Meeting, Davis, CA, Nov. 7-8, 2013 Yoshi Ohno Experiment on White Light Chromaticity for Lighting ­ Duv levels Perceived Most Natural ­ #12;2CIE/USA-CNC.3762001 for fluorescent lamps IEC 60081 for Fluorescent Lamps #12;3CIE/USA-CNC/CIE 2013 ANSI C78.377-2011 (for Solid State

  8. ULTRACAM photometry of the ultracompact binaries V407 Vul and HM Cnc

    NASA Astrophysics Data System (ADS)

    Barros, S. C. C.; Marsh, T. R.; Dhillon, V. S.; Groot, P. J.; Littlefair, S.; Nelemans, G.; Roelofs, G.; Steeghs, D.; Wheatley, P. J.

    2007-02-01

    V407 Vul (RXJ1914.4+2456) and HM Cnc (RXJ0806.3+1527) are X-ray emitting stars with X-ray light curves that are 100 per cent modulated on periods of 569 and 321 s, respectively. These periods are thought possibly to represent the orbital periods of close pairs of white dwarfs. In this paper we present optical light curves taken with the high-speed CCD camera ULTRACAM on the 4.2-m William Hershel Telescope in 2003 May and 2005 August and with the VLT in 2005 November. The optical and X-ray light curves of HM Cnc have been reported as being in antiphase, but we find that in fact the X-rays peak around 0.2 cycles after the maximum of the optical light, as seen also in V407 Vul. The X-ray/optical phase shifts are well explained under the accreting models of the systems if most of the optical modulation comes from the heated faces of the mass donors and if the X-ray emitting spots are positioned in advance of the mass donors, as is expected given the angular momentum of the accreting material. Some optical emission may also come from the vicinity of the X-ray spot, and we further show that this can explain the non-sinusoidal light curves of HM Cnc. On the basis of this model we constrain the temperature of the heated face of the companion star finding a bolometric luminosity >1033ergs-1 and a distance, d > 1.1 kpc. We can identify no explanation for the X-ray/optical phase shifts under the intermediate polar and unipolar inductor models of the systems. The only significant difference between the two stars is that V407 Vul is observed to have the spectrum of a G star. The variation in position on the sky of a blend of a variable and a constant star can be used as a measure of their separation, and is sensitive to values well below the limit set by seeing. We apply this `pulsation astrometry' to deduce that the G star is separated from the variable by about 0.027 arcsec and hence plays no role in the variability of V407 Vul. We show that light traveltime variations could influence the period change in V407 Vul if it forms a triple system with the G star.

  9. FEATURE-BASED CNC PROGRAMMING ENVIRONMENT ON THE INTERNET

    Microsoft Academic Search

    Dan Wu; Zhiyang Yao; Linda C. Schmidt

    2000-01-01

    Effective global manufacturing enterprises require internet-based tools and technologies to virtually integrate the efforts of customers, designers, and manufacturers who work in separate office buildings or on separate continents. We present the framework for an internet- accessible, feature-based, CNC programming environment. The environment empowers users from different geographical sites to control CNC machining processes via real-time simulations, remote access, and

  10. Intelligent Programming of CNC Turning Operations using Genetic Algorithm

    Microsoft Academic Search

    Joze Balic; Miha Kovacic; Bostjan Vaupotic

    2006-01-01

    CAD\\/CAM systems are nowadays tightly connected to ensure that CAD data can be used for optimal tool path determination and\\u000a generation of CNC programs for machine tools. The aim of our research is the design of a computer-aided, intelligent and genetic\\u000a algorithm(GA) based programming system for CNC cutting tools selection, tool sequences planning and optimisation of cutting\\u000a conditions. The first

  11. Ease of Use with Concurrent Collections (CnC)

    Microsoft Academic Search

    Kathleen Knobe

    Parallel programming is hard. We present a new approach called Concurrent Collections (CnC). This paper briefly explains why writing a parallel program is hard in the current environment and introduces our new approach based on this perspective. In particular, a CnC program doesn't explicitly express the parallelism. It expresses the con- straints on parallelism. These constraints remain valid regardless of

  12. CNC tool path in terms of B-spline curves

    Microsoft Academic Search

    Claire Lartigue; François Thiebaut; Takashi Maekawa

    2001-01-01

    We present an accurate and efficient method to generate a CNC tool path for a smooth free-form surface in terms of planar cubic B-spline curves which will be fed into a free-form curve interpolator. We assume the use of a three-axis CNC machine tool with a ball end-mill cutter. We first interpolate break points, which are generated by computing the

  13. A high speed machining algorithm for CNC machine tools

    Microsoft Academic Search

    Guk-Chan Han; Dong-II Kim; Hyo-Gyu Kim; Kibeohn Nam; Byeong-Kap Choi; Sung-Kwun Kim

    1999-01-01

    This paper introduces a high speed machining algorithm based on a look-ahead interpolation technique for the machining of 3D surface obtained by a CAD\\/CAM system. Generally, specification of CNC system for high speed machining requires an additional hardware and it burdens end users with additional cost. The purpose of this research is to develop the low cost CNC controller having

  14. Real-time CNC interpolators for Pythagorean-hodograph curves

    Microsoft Academic Search

    Rida T. Farouki; Sagar Shah

    1996-01-01

    CNC machining requires “interpolation” algorithms that accurately and efficiently generate sequences of reference positions, distributed according to a prescribed feedrate function, along the tool paths. CNC interpolators have traditionally accommodated only linear and circular trajectories, on account of the absence of easily-calculable relations between the arc length s and parameter ? for free-form parametric curves. With the Pythagorean-hodograph (PH) curves,

  15. An active axis control system for a conventional CNC machine

    Microsoft Academic Search

    Daniel Hanafi; Michal Tordon; Jayantha Katupitiya

    2003-01-01

    A non-invasive approach to implement an active axis controller for a conventional CNC machine is presented. To develop the system a two-stage approach has been taken. In stage one, a generic external axis controller is designed to bring the machine under the real-time control of an external computer. The external controller is interfaced to the CNC machine via the Manual

  16. ULTRACAM Photometry of the ultracompact binaries V407 Vul and HM Cnc

    E-print Network

    S. C. C. Barros; T. R. Marsh; V. S. Dhillon; P. J. Groot; S. Littlefair; G. Nelemans; G. Roelofs; D. Steeghs; P. J. Wheatley

    2006-11-03

    V407 Vul (RXJ1914.4+2456) and HM Cnc (RXJ0806.3+1527) are X-ray emitting stars with X-ray light curves that are 100% modulated on periods of 569 and 321 seconds respectively. These periods are thought possibly to represent the orbital periods of close pairs of white dwarfs. In this paper we present optical light curves taken with the high-speed CCD camera ULTRACAM on the 4.2m WHT in May 2003 and August 2005 and with the VLT in November 2005. The optical and X-ray light curves of HM Cnc have been reported as being in anti-phase, but we find that in fact the X-rays peak around 0.2 cycles after the maximum of the optical light, as seen also in V407 Vul. The X-ray/optical phase shifts are well explained under the accreting models of the systems if most of the optical modulation comes from the heated faces of the mass donors and if the X-ray emitting spots are positioned in advance of the mass donors, as is expected given the angular momentum of the accreting material. Some optical emission may also come from the vicinity of the X-ray spot, and we further show that this can explain the non-sinusoidal lightcurves of HM Cnc. The only significant difference between the two stars is that V407 Vul is observed to have the spectrum of a G star. The variation in position on the sky of a blend of a variable and a constant star can be used as a measure of their separation, and is sensitive to values well below the limit set by seeing. We apply "pulsation astrometry" to deduce that the G star is separated from the variable by about 0.027'' and hence plays no role in the variability of V407 Vul. We show that light travel time variations could influence the period change in V407 Vul if it forms a triple system with the G star.

  17. Characterising the atmosphere of the super-Earth 55Cnc e

    NASA Astrophysics Data System (ADS)

    de Mooij, Ernst

    2014-10-01

    So-called "super-Earth" planets could come in a variety of flavors, but to date we have few observational constraints on their diversity. In fact, atmospheres of only two members of the class have been measured in transmission so far. Here we propose to observe two transits of the third of that class that can be characterised, the super-Earth 55Cnc e, orbiting the brightest star in the sky known to harbor a transiting planet, using WFC3 in the near-infrared. This planet's low average density implies either a significant water fraction or a hydrogen-rich envelope. However, given the intensity of its stellar insolation, a hydrogen-rich envelope is expected to have evaporated. If, on the other hand, 55Cnc e contains a large water fraction, it is expected to have a small scale-height envelope dominated by water. Our proposed observations will not only investigate its atmospheric properties and constrain the scale-height, but also demonstrate HST's capabilities for characterizing small planets around nearby, bright stars, which will be prime targets for upcoming surveys such as the TESS mission.

  18. Detection of a transit of the super-Earth 55 Cnc e with Warm Spitzer

    E-print Network

    Demory, B -O; Deming, D; Valencia, D; Seager, S; Benneke, B; Lovis, C; Cubillos, P; Harrington, J; Stevenson, K B; Mayor, M; Pepe, F; Queloz, D; Segransan, D; Udry, S

    2011-01-01

    We report on the detection of a transit of the super-Earth 55 Cnc e with Warm Spitzer in IRAC's 4.5-micron band. Our MCMC analysis includes an extensive modeling of the systematic effects affecting Warm Spitzer photometry, and yields a transit depth of 450 +- 50 ppm, which translates to a planetary radius of 2.13 +- 0.14 Earth Radii as measured in IRAC 4.5-micron channel. A planetary mass of 7.98 +- 0.69 Earth Masses is derived from an extensive set of radial-velocity data, yielding a planetary density of 0.83 +- 0.18 Earth density. Interestingly, the derived radius is 1.3 times larger than the one recently reported in the visible by Winn et al. Thanks to the brightness of its host star (V=6, K=4), 55 Cnc e is a unique target for the thorough characterization of a super-Earth orbiting around a solar-type star.

  19. MOST satellite photometry of stars in the M67 field: Eclipsing binaries, blue stragglers and delta-Scuti variables

    E-print Network

    Theodor Pribulla; Slavek Rucinski; Jaymie M. Matthews; Rainer Kuschnig; Jason F. Rowe; David B. Guenther; Anthony F. J. Moffat; Dimitar Sasselov; Gordon A. H. Walker; Werner W. Weiss

    2008-09-02

    We present two series of MOST (Microvariability & Oscillations of STars) space-based photometry, covering nearly continuously 10 days in 2004 and 30 days in 2007, of selected variable stars in the upper Main Sequence of the old open cluster M67. New high-precision light curves were obtained for the blue-straggler binary/triple systems AH Cnc, ES Cnc and EV Cnc. The precision and phase coverage of ES Cnc and EV Cnc is by far superior to any previous observations. The light curve of ES Cnc is modelled in detail, assuming two dark photospheric spots and Roche geometry. An analysis of the light curve of AH Cnc indicates a low mass ratio (q about 0.13) and a high inclination angle for this system. Two new long-period eclipsing binaries, GSC 814-323 and HD75638 (non-members of M67) were discovered. We also present ground-based DDO spectroscopy of ES Cnc and of the newly found eclipsing binaries. Especially interesting is HD75638, a member of a visual binary, which must itself be a triple or a higher-multiplicity system. New light curves of two delta Scuti pulsators, EX Cnc and EW Cnc, have been analyzed leading to detection of 26 and 8 pulsation frequencies of high temporal stability.

  20. CNC grinding of valve housing piston holes

    SciTech Connect

    Ashbaugh, F.A.

    1991-11-01

    Grinding has traditionally been used for machining operations requiring close dimensional tolerances and better surface finishes than can be obtained from other metal removal techniques. Using a grinding process for the last metal removal operation, the close tolerances and surface finishes can be easily held while eliminating the adverse conditions from the current metal removal processes. Pre-machined test parts were sent to a machine tool supplier to have the critical inside features of a typical piston bore finish machined using an internal CNC grinder equipped with high-frequency spindles. The piston bore and sealing angle were ground using a standard 120-grit silicon carbide wheel. The wafer step was machined using a solid carbide tool designed and built at Allied-Signal Inc., Kansas City Division (KCD). Six consecutive parts were machined for evaluation. The repeatability on all six parts was within print requirements. The inside corner radii was less than 0.002 in. and the surface finish was 8.2 arithmetical average or better as defined by ANSI B46.1, Surface Texture. Machining parts by this grinding process would eliminate bellmouth, chatter, waviness, and traveler polishing operations. It would produce a superior surface finish, small inside radii, and small easily removable burrs. It would also hold tolerances closer and significantly reduce scrap, rework, rejects, and deviations. 1 fig.

  1. Final Report: CNC Micromachines LDRD No.10793

    SciTech Connect

    JOKIEL JR., BERNHARD; BENAVIDES, GILBERT L.; BIEG, LOTHAR F.; ALLEN, JAMES J.

    2003-04-01

    The three-year LDRD ''CNC Micromachines'' was successfully completed at the end of FY02. The project had four major breakthroughs in spatial motion control in MEMS: (1) A unified method for designing scalable planar and spatial on-chip motion control systems was developed. The method relies on the use of parallel kinematic mechanisms (PKMs) that when properly designed provide different types of motion on-chip without the need for post-fabrication assembly, (2) A new type of actuator was developed--the linear stepping track drive (LSTD) that provides open loop linear position control that is scalable in displacement, output force and step size. Several versions of this actuator were designed, fabricated and successfully tested. (3) Different versions of XYZ translation only and PTT motion stages were designed, successfully fabricated and successfully tested demonstrating absolutely that on-chip spatial motion control systems are not only possible, but are a reality. (4) Control algorithms, software and infrastructure based on MATLAB were created and successfully implemented to drive the XYZ and PTT motion platforms in a controlled manner. The control software is capable of reading an M/G code machine tool language file, decode the instructions and correctly calculate and apply position and velocity trajectories to the motion devices linear drive inputs to position the device platform along the trajectory as specified by the input file. A full and detailed account of design methodology, theory and experimental results (failures and successes) is provided.

  2. 78 FR 50135 - CNC Development, Ltd., Exousia Advanced Materials, Inc., and South American Minerals, Inc.; Order...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ...SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] CNC Development, Ltd., Exousia Advanced Materials, Inc., and...current and accurate information concerning the securities of CNC Development, Ltd. because it has not filed any periodic...

  3. Time synchronization of hierarchical real-time networked CNC system based on ethernet\\/internet

    Microsoft Academic Search

    Xiang-li Zhang; Xiao-qi Tang; Ji-hong Chen

    2008-01-01

    With the development of Ethernet\\/Internet, using Ethernet\\/Internet technology to implement the communication of computer numerical\\u000a control (CNC) system is a new research field of networked CNC system. To support the synchronization control of the CNC system\\u000a based on Ethernet\\/Internet, a time synchronization solution for the hierarchical real-time networked CNC system based on Ethernet\\/Internet\\u000a is designed in this paper. To evaluate

  4. Architecture and implementation of a shop-floor programming system for STEP-compliant CNC

    Microsoft Academic Search

    Suk-hwan Suh; Byeong-eon Lee; Dae-hyuck Chung; S. U. Cheon

    2003-01-01

    STEP-NC (formalized as ISO 14649 and ISO 10303 AP238) is a new interface (or language) standard for the CAD–CAM–CNC chain, currently under establishment by ISO TC184 SC1 and SC4. Upon completion, it will replace ISO 6983, so called M & G codes used for CNC since 1950s. As the new language is being established, a new CNC controller called STEP-CNC

  5. Drilling of circuit boards using CNC controlled by programable logic controller

    Microsoft Academic Search

    Pavel Sofer; Jaromir Skuta; Jan Gebauer

    2012-01-01

    The paper is devoted to 3-axis positioning of a CNC machine model. This desktop CNC machine is used here as a tool for circuit board holes drilling, designed using the EAGLE software. Connection between the EAGLE software and the CNC machine model is provided by monitoring and visualization application, created in the visualization system Control Web 6. This application receives

  6. ADAPTIVE CORRECTION OF ERRORS IN CNC TURNING USING ARTIFICIAL NEURAL NETWORKS

    Microsoft Academic Search

    T. S. Suneel; S. S. Pande

    2000-01-01

    This paper presents the development of an intelligent adaptive correction tool for im- proving the profile accuracy of parts produced on CNC turning centers. Actual dimensions and shape (form) produced on components during machining differ from the nominal dimensions commanded in the CNC program. The error if predicted apriori can be used to correct the ideal CNC code and thus

  7. CNC Turning Center Advanced Operations. Computer Numerical Control Operator/Programmer. 444-332.

    ERIC Educational Resources Information Center

    Skowronski, Steven D.; Tatum, Kenneth

    This student guide provides materials for a course designed to introduce the student to the operations and functions of a two-axis computer numerical control (CNC) turning center. The course consists of seven units. Unit 1 presents course expectations and syllabus, covers safety precautions, and describes the CNC turning center components, CNC

  8. CNC Machine Tool's Wear Diagnostic and Prognostic by Using Dynamic Bayesian Networks

    E-print Network

    Paris-Sud XI, Université de

    CNC Machine Tool's Wear Diagnostic and Prognostic by Using Dynamic Bayesian Networks D.A. Tobon of the health condition of a Computer Numerical Control (CNC) tool machine and the estimation of its Remaining of a CNC tool. Simulation results are obtained and discussed at the end of the paper. Keywords: Diagnostic

  9. A fast tool servo design for precision turning of shafts on conventional CNC lathes

    Microsoft Academic Search

    Wen-Hong Zhu; Martin B. Jun; Yusuf Altintas

    2001-01-01

    A technique for precision turning of shafts on conventional CNC turning centers is presented. The shaft is semi-turned on a conventional CNC lathe. The precision finish turning operation is delivered by a piezoelectric based fast tool servo which is mounted on the same CNC lathe's turret. The precision tool tip motion is delivered by a proposed sliding mode controller which

  10. Maximum Feedrate Interpolator for Multi-axis CNC Machining with Jerk Constraints

    E-print Network

    Paris-Sud XI, Université de

    Maximum Feedrate Interpolator for Multi-axis CNC Machining with Jerk Constraints X. Beudaert, S name@lurpa.ens-cachan.fr Abstract A key role of the CNC is to perform the feedrate interpolation which for the next point along the path is computed. Examples and comparisons with an industrial CNC demonstrate

  11. Precise Gouging-free Tool Orientations for 5-Axis CNC Machining Yong-Joon Kima

    E-print Network

    Pottmann, Helmut

    Precise Gouging-free Tool Orientations for 5-Axis CNC Machining Yong-Joon Kima , Gershon Elbera-free tool paths for 5-axis CNC machining of freeform NURBS surfaces using flat-end and rounded-end (bull modeling and have been widely used in a variety of applications. Consequently, CNC machining of NURBS

  12. Radial Error Feedback Geometric Adaptive Control for Bar Turning in CNC Turning Centers

    E-print Network

    Collins, Emmanuel

    Radial Error Feedback Geometric Adaptive Control for Bar Turning in CNC Turning Centers by Chun Fan-6046 liu@eng.fsu.edu, indwang1@eng.fsu.edu Abstract In-process measurement and control of CNC machines can adaptive control (REFGAC) system for bar turning in CNC turning centers. REFGAC system was design to com

  13. Measuring the Overhead of Intel C++ CnC over TBB for Gauss-Jordan Elimination

    E-print Network

    Tang, Peiyi

    Measuring the Overhead of Intel C++ CnC over TBB for Gauss-Jordan Elimination Peiyi Tang Department only by the data dependencies be- tween the tasks. Both Intel C++ Concurrent Col- lections (CnC algorithm and implemented it in TBB. We compare the performances of TBB and CnC, which is built on top

  14. Direct Trajectory Interpolation on the Surface using an Open CNC Xavier Beudaert Sylvain Lavernhe Christophe Tournier

    E-print Network

    Paris-Sud XI, Université de

    Direct Trajectory Interpolation on the Surface using an Open CNC Xavier Beudaert · Sylvain Lavernhe format of the industrial CNC. Then, during the tool path interpolation, marks on fin- ished surfaces can of the data exchange between CAD/CAM and CNC opens new ways to optimize the manufacturing process. The Direct

  15. ME/AE 381 Mechanical and Aerospace Control Systems MINI CNC LABORATORY

    E-print Network

    Landers, Robert G.

    ME/AE 381 ­ Mechanical and Aerospace Control Systems MINI CNC LABORATORY The objective of this laboratory is to design controllers that will regulate the position of three linear axes in a table top CNC tracking controllers in the laboratory using the mini CNC Rapid Development System. Plot the linear axis

  16. Making CNC machine tools more open, interoperable and intelligent - a review of the technologies

    Microsoft Academic Search

    X. W. Xu; Stephen T. Newman

    2006-01-01

    The aim of the next generation of computer numerically controlled (CNC) machines is to be portable, interoperable and adaptable. Over the years, G-codes (ISO 6983) have been extensively used by the CNC machine tools for part programming and are now considered as a bottleneck for developing next generation of CNC machines. A new standard known as STEP-NC is being developed

  17. Optical flares and flaring oscillations on the M-type eclipsing binary CU Cnc

    E-print Network

    -B., Qian S; Zhu, L -Y; Liu, L; Liao, W -P; Zhao, E -G; He, J -J; Li, L -J; Li, K; Dai, Z -B

    2012-01-01

    We report here the discovery of an optical flare observed in R band from the red-dwarf eclipsing binary CU Cnc whose component stars are at the upper boundary of full convection (M1=0.43 and M2=0.4M0, M0 is the solar mass). The amplitude of the flare is the largest among those detected in R band (~0.52mag) and the duration time is about 73 minutes. As those observed on the Sun, quasi-periodic oscillations were seen during and after the flare. Three more R-band flares were found by follow up monitoring. In total, this binary was monitored photometrically by using R filter for 79.9 hours, which reveals a R-band flare rate about 0.05 flares per hour. These detections together with other strong chromospheric and coronal activities, i.e., very strong H_alpha and H_beta emission features and an EUV and X-ray source, indicate that it has very strong magnetic activity. Therefore, the apparent faintness (~1.4 magnitude in V) of CU Cnc compared with other single red dwarfs of the same mass can be plausibly explained by...

  18. Ground-Based Transit Observations of the Super-Earth 55 Cnc e

    E-print Network

    de Mooij, E J W; Karjalainen, R; Hrudkova, M; Jayawardhana, R

    2014-01-01

    We report the first ground-based detections of the shallow transit of the super-Earth exoplanet 55 Cnc e using a 2-meter-class telescope. Using differential spectrophotometry, we observed one transit in 2013 and another in 2014, with average spectral resolutions of ~700 and ~250, spanning the Johnson BVR photometric bands. We find a white-light planet-to-star radius ratio of 0.0190 -0.0027+0.0023 from the 2013 observations and 0.0200 -0.0018+0.0017 from the 2014 observations. The two datasets combined results in a radius ratio of 0.0198 -0.0014+0.0013. These values are all in agreement with previous space-based results. Scintillation noise in the data prevents us from placing strong constraints on the presence of an extended hydrogen-rich atmosphere. Nevertheless, our detections of 55 Cnc e in transit demonstrate that moderate-size telescopes on the ground will be capable of routine follow-up observations of super-Earth candidates discovered by the Transiting Exoplanet Survey Satellite (TESS) around bright st...

  19. Capturing and Composing Parallel Patterns with Intel CnC Ryan Newton Frank Schlimbach Mark Hampton Kathleen Knobe

    E-print Network

    Gummadi, Ramakrishna

    Capturing and Composing Parallel Patterns with Intel CnC Ryan Newton Frank Schlimbach Mark Hampton to encapsulate only a single pattern. Thus we explore the use of Intel CnC as a single frame- work for capturing. In this paper, we consider Intel Concurrent Collections (CnC)[9]. as a candidate substrate for patterns. CnC

  20. Close binary and other variable stars in the solar-age Galactic open cluster M 67

    NASA Astrophysics Data System (ADS)

    Yakut, K.; Zima, W.; Kalomeni, B.; van Winckel, H.; Waelkens, C.; De Cat, P.; Bauwens, E.; Vu?kovi?, M.; Saesen, S.; Le Guillou, L.; Parmaks?zo?lu, M.; Uluç, K.; Khamitov, I.; Raskin, G.; Aerts, C.

    2009-08-01

    We present multi-colour time-series CCD photometry of the solar-age galactic open cluster M 67 (NGC 2682). About 3600 frames spread over 28 nights were obtained with the 1.5 m Russian-Turkish and 1.2 m Mercator telescopes. High-precision observations of the close binary stars AH Cnc, EV Cnc, ES Cnc, the ? Scuti type systems EX Cnc and EW Cnc, and some long-period variables belonging to M 67 are presented. Three full multi-colour light curves of the overcontact binary AH Cnc were obtained during three observing seasons. Likewise we gathered three light curves of EV Cnc, an EB-type binary, and two light curves of ES Cnc, a blue straggler binary. Parts of the light change of long-term variables S1024, S1040, S1045, S1063, S1242, and S1264 are obtained. Period variation analysis of AH Cnc, EV Cnc, and ES Cnc were done using all times of mid-eclipse available in the literature and those obtained in this study. In addition, we analyzed multi-colour light curves of the close binaries and also determined new frequencies for the ? Scuti systems. The physical parameters of the close binary stars were determined with simultaneous solutions of multi-colour light and radial velocity curves. Finally we determined the distance of M 67 as 857(33) pc via binary star parameters, which is consistent with an independent method from earlier studies. Based on observations made with the Mercator Telescope, operated on the island of La Palma by the Flemish Community, at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias and TÜB?TAK National Observatory Russian-Turkish telescope operated at Sakl?kent, Antalya.

  1. PROMOTING A VIRTUAL TRAINING ENVIRONMENT FOR CNC Faruk nsaar

    E-print Network

    Aristomenis, Antoniadis

    more and more automated through the use of CAD/CAM systems. Furthermore continuous developments. The facilities for CNC training vary a lot and this has had direct impact on the experience that the trainee vary a lot and it has a direct impact on the experience that the trainee is acquiring during his

  2. CANADIAN GEOTECHNICAL CONFERENCE JOINT IAH-CNC/CGS CONFERENCE

    E-print Network

    Aubertin, Michel

    56TH CANADIAN GEOTECHNICAL CONFERENCE 4TH JOINT IAH-CNC/CGS CONFERENCE 2003 NAGS CONFERENCE 56ième properties of the backfill. The models were experimentaly validated. The programming of the developed can effectively manage backfill technology. Hence, multi-disciplinary research programs are carried

  3. CANADIAN GEOTECHNICAL CONFERENCE JOINT IAH-CNC/CGS CONFERENCE

    E-print Network

    Zornberg, Jorge G.

    56TH CANADIAN GEOTECHNICAL CONFERENCE 4TH JOINT IAH-CNC/CGS CONFERENCE 2003 NAGS CONFERENCE 56ième in stability analyses using the proposed discrete framework. The experimental testing program involves tensile in the experimental testing program. RÉSUMÉ: Une étude expérimentale a été dirigée pour valider une méthodologie

  4. Feature based automatic CNC code generation for prismatic parts

    Microsoft Academic Search

    Rajiv B. Karadkar; S. S. Pande

    1996-01-01

    This paper reports the design and implementation of prisplan — a generative feature based process planning system for prismatic components. The system comprises two important modules — a solid based feature modeller and the automated process planning module for CNC code generation. The feature based modeller provides an interactive graphical environment for part synthesis, while the process planning module facilitates

  5. An efficient CNC programming approach based on group technology

    Microsoft Academic Search

    Manocher Djassemi

    2000-01-01

    Many studies and reports support the significant impact of the application of group technology on various aspects of product design and manufacturing. The fact that group technology is the common solution to similar problems is the main source of such impact. In this paper, one of the less frequently utilized features of CNC technology known as parametric part programming is

  6. Development of an open CNC based on industrial Ethernet

    Microsoft Academic Search

    Xuhui Zhang; Sunan Wang; Qin Liu

    2008-01-01

    The conventional CNC lacks of flexibility for network and integration in manufacturing, because of its close architecture and network shortage etc., one of the effective measures to solve the problems is ONC (open numerical control). But the ONC based PC cannot carry out open architecture from core, results in resource wasted seriously and needs to study its reliability further. This

  7. Design and performance of a small precision CNC turning machine

    Microsoft Academic Search

    R. R. Donaldson; D. C. Thompson; E LOEWEN

    1986-01-01

    This paper describes the design of a CNC turning machine that is capable of machining workpieces up to 100 mm in diameter with a high contour accuracy and a very low surface roughness. Two nearly identical machines have been built and put into operation using this design, one for serial parts manufacture and the other for research into improving the

  8. Simulation of thermal behavior of a CNC machine tool spindle

    Microsoft Academic Search

    Zhao Haitao; Yang Jianguo; Shen Jinhua

    2007-01-01

    The thermal deformations of a CNC machine tool spindle are the major contributor of thermal error. It is very significant both theoretically and practically to study how to accurately simulate the thermal error of the spindle. Firstly, this paper proposes a method for computing the coefficient of convection heat transfer of the spindle surface by referencing the theory on computing

  9. Implementation of Additive Rapid Prototyping on Retrofit CNC Mill

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Freeform fabrication techniques are gaining popularity as a means of making parts. Layered additive methods are associated with rapid prototyping. Many rapid prototyping methods are commercially proprietary and may cost thousands of dollars. Using a retrofit CNC mill for layered fabrication and C...

  10. Forming strategies and Process Modelling for CNC Incremental Sheet Forming

    Microsoft Academic Search

    G. Hirt; J. Ames; M. Bambach; R. Kopp

    2004-01-01

    Incremental Sheet Forming (ISF) is a process capable of producing complex sheet components by the CNC movement of a simple tool in combination with simplified dies. Earlier work revealed two major process limits, namely the limitation on the maximum achievable wall angle, and the occurrence of geometric deviations. The work detailed in this paper focuses on forming strategies to overcome

  11. Two X-Ray Bright Cataclysmic Variables with Unusual Activities: GZ Cnc and NSV 10934

    E-print Network

    T. Kato; P. A. Dubovsky; R. Stubbings; M. Simonsen; H. Yamaoka; P. Nelson; B. Monard; A. Pearce; G. Garradd

    2002-10-01

    We report on a discovery of unexpected activities in two X-ray bright dwarf novae. GZ Cnc showed an anomalous clustering of outbursts in 2002, in contrast to a low outburst frequency in the past record. The activity resembles an increased activity seen in some intermediate polars or candidates. We identified NSV 10934, X-ray selected high-amplitude variable star, as a dwarf nova with unusually rapid decline. The outburst characteristics make NSV 10934 a twin of recently discovered intermediate polar (HT Cam) with dwarf nova-type outbursts. We propose that these activities in X-ray strong dwarf novae may be a previously overlooked manifestation of outburst activities in magnetic cataclysmic variables.

  12. New ephemerides for 120 eclipsing binary stars

    NASA Astrophysics Data System (ADS)

    Mallama, A. D.

    1980-10-01

    New ephemerides based on data from 1968 to 1978 have been derived for 120 eclipsing binary stars with Algol-like light curves. The original visual timings are grouped into yearly normals of rather high accuracy. The program stars are: RT And, UU And, xZ And, RY Aqr, CX Aqr, CZ Aqr, EE Aqr, V346 Aql, WW Aur, UW Boo, ZZ Boo, Y Cam, SV Cam, AL Cam, TU Cnc, R CMa, RX CMa, TU CMa, AG CMi, TV Cap, Rz Cas, TV Cas, AB Cas, U Cep, EG Cep, RW Cet, U CrB, V Crt, Y Cyg, SW Cyg, UW Cyg, WW Cyg, zZ Cyg, AE Cyg, V456 Cyg, V477 Cyg, V687 Cyg, V728 Cyg, W Del, TY Del, YY Del, FZ Del, Z Dra, RR Dra, TW Dra, A' Dra, S Equ, TZ Eri, WX Eri, RW Gem, TX Gem, YY Gem, AF Gem, RX Her, SZ Her, TU Her, TX Her, UX Her, CC Her, CT Her, V338 Her, RX Hya, TW Lac, VX Lac, AU Lac, CM Lac, Y Leo, RW Leo, UU Leo, UV Leo, T LMi, RS Lep, Lib, UZ Lyr, EW Lyr, FL Lyr, RW Mon, TU Mon, BO Mon, U Oph, RV Oph, V449 Oph, FL Ori, FT Ori, UX Peg, BN Peg, DI Peg, Z Per, RT Per, RV Per, ST Per, xZ Per, p Per, Y Psc, xZ Pup, U Sge, XY Sgr, V505 Sgr, RS Sct, AK Ser, AO Ser, RW Tau, HU Tau, X Tri, TX UMa, UX UMa, vV UMa, xZ UMa, zZ UMa, W UMi, RU UMi, UW Vir, AK Vir, BF Vir, BH Vir, Z Vul, AX Vul, BE Vul, BO Vul, and BU Vul.

  13. The Research of CNC Communication Based on Industrial Ethernet

    Microsoft Academic Search

    Jianqiao Xiong; Xiaosong Xiong; Xue Li; Bin Yu

    \\u000a Firstly, analyzing several interfaces of the current CNC machine tools, then proposing connecting them with Industrial Ethernet\\u000a and a kind of topologic structure based on Industrial Ethernet.Concretely illuminating the frame structure of digital interface\\u000a and communication mode of EtherCAT,and analyzing and evaluating the functions and characteristics of the Industrial Ethernet.Finally,\\u000a a method for designing based on hardware and software of

  14. Incremental sheet metal forming on CNC milling machine-tool

    Microsoft Academic Search

    J. Kopac; Z. Kampus

    2005-01-01

    Incremental sheet metal forming is a promising process providing a short and inexpensive way of forming products having a relatively simple but interesting shape. The paper presents the process controlled by CNC milling machine-tool together with CAD\\/CAM Master Cam system and a smooth forming tool. With experimental testing and measurements the limits of forming without a full-size model were defined.

  15. Real-time NURBS command generators for CNC servo controllers

    Microsoft Academic Search

    M.-Y. Cheng; M.-C. Tsai; J.-C. Kuo

    2002-01-01

    This study proposes a real-time Non-Uniform Rational B-Spline (NURBS) motion command generator for computer numerical control (CNC) machines to achieve the goal of high-speed and highly accurate machining. Different numerical algorithms for implementing the NURBS motion command generator are compared on the basis of both the computation time and the precision of geometric representation. In addition, to reduce the computation

  16. An Internet-Based Virtual CNC Milling System

    Microsoft Academic Search

    S. K. Ong; L. Jiang; A. Y. C. Nee

    2002-01-01

    This paper addresses the importance of integrating a virtual Manufacturing (VM) system with the Internet and proposes a web-based,\\u000a scalable and distributed architecture for developing a platform-independent VM system. A prototype web-based virtual CNC milling\\u000a system has been developed using Virtual Reality Modelling Language and Java. The user can easily set up machining conditions,\\u000a operate the virtual milling machine in

  17. A Framework for an Intelligent CNC and Data Model

    Microsoft Academic Search

    S.-H. Suh; S.-U. Cheon

    2002-01-01

    In this paper, we present a conceptual framework for designing and implementing an intelligent CNC system. The architecture\\u000a and functional modules are derived from requirement analysis, and they are designed to have a thinking capability before,\\u000a during, and after the execution of the manufacturing task, so that the assigned task can be effectively executed while dealing\\u000a with unexpected changes occurring

  18. Design of reconfigurable CNC system based on embedded technology

    Microsoft Academic Search

    Yue Xu; Taiyong Wang; Yanju Zhao; Jingchuan Dong

    2008-01-01

    A CNC system which was based on embedded processors and embedded-real-time-operating system was structured. Its hardware platform which is of dual-CPU model is designed by ARM and DSP. This structure is used to control production process. FPGA module realizes systempsilas flexible manufacturing and reconfiguration. Due to the disadvantages of single task software structure this paper uses embedded real time operating

  19. Retrofitment of a CNC machine for hybrid layered manufacturing

    Microsoft Academic Search

    K. P. Karunakaran; S. Suryakumar; Vishal Pushpa; Sreenathbabu Akula

    2009-01-01

    Subtractive manufacturing [computer numerical controlled (CNC) machining] has high quality geometric and material properties\\u000a but is slow, costly, and infeasible in some cases. On the contrary additive manufacturing (rapid prototyping) has total automation\\u000a but compromises quality. A hybrid layered manufacturing process presented in this study combines the best features of both\\u000a these approaches. It uses arc weld deposition for building

  20. Ubiquitous-based mobile control and monitoring of CNC machines for development of u-machine

    Microsoft Academic Search

    Dong-Hoon Kim; Jun-Yeob Song

    2006-01-01

    This study was an attempt to control and monitor Computerized Numerical Controller (CNC) machines anywhere and anytime for\\u000a the development of a ubiquitous machine (u-machine). With a Personal Digital Assistant (PDA) phone, the machine status and\\u000a machining data of CNC machines can be monitored in wired and wireless environments, including the environments of IMT2000\\u000a and Wireless LAN. Moreover, CNC machines

  1. Standard process monitoring and traceability programming in collaborative CAD\\/CAM\\/CNC manufacturing scenarios

    Microsoft Academic Search

    Julio Garrido Campos; Luis Rodriguez Miguez

    2011-01-01

    The paper focuses on collaborative STEP-based CAD\\/CAM\\/CNC supply chains to program and automate machining process data monitoring and traceability activities. A traceability interface (traceability nc_functions) is defined for the new CNC programming standard ISO STEP-NC. CAM systems will be able to program monitoring and data access activities by inserting traceability nc_function calls in CNC programs. On the shop floor, controllers

  2. Research of communication mechanism in CNC system based on EtherCAT

    Microsoft Academic Search

    Mingzhong Zhang; Yongming Chen; Yin Li

    2011-01-01

    EtherCAT (Ethernet for Control Automation Technology) is a type of real-time industrial Ethernet protocol for date communication in automation control system, which is used in the pure-soft open CNC system communication. In this solution named ADX CNC, CNC system is the master station and communicates data through the NIC of Industrial PC with slave stations without any other cards. To

  3. Autonomously Proficient CNC Controller for High-Performance Machine Tools Based on an Open Architecture Concept

    Microsoft Academic Search

    Kazuo Yamazaki; Yoshimaro Hanaki; Masahiko Mori; Kazusaka Tezuka

    1997-01-01

    The paper deals with the new controller for the high performance CNC machine tools. The controller proposed is referred to as “TRUE-CNC.” “TRUE” means Transparent, Transportable and Transplantable, Revivable, User-reconfigurable, and Evolving. TRUE-CNC allows the operator to achieve the maximum productivity and highest possible quality of the machined parts in a given environment with autonomous capturing of the machining operation

  4. Modeling and control of cnc machines using a PC-based open architecture controller

    Microsoft Academic Search

    Stephen J. Rober; Yung C. Shin

    1995-01-01

    A PC-based open architecture computer numerical controller (CNC) is introduced to control milling machines. The controller is implemented on two systems: (1) a single-axis high speed milling machine using analog control signals where the PC-based controller assumes all CNC functions and (2) a three-axis milling machine controlled by digital signals where the existing CNC continues to monitor peripheral functions but

  5. Accuracy enhancement of five-axis CNC machines through real-time error compensation

    Microsoft Academic Search

    W. T Lei; Y. Y Hsu

    2003-01-01

    Although error modeling and compensation have given significant results for three-axis CNC machine tools, a few barriers have prevented this promising technique from being applied in five-axis CNC machine tools. One crucial barrier is the difficulty of measuring or identifying link errors in the rotary block of five-axis CNC machine tools. The error model is thus not fully known. To

  6. Constitutive activation of Drosophila CncC transcription factor reduces lipid formation in the fat body.

    PubMed

    Karim, M Rezaul; Taniguchi, Hiroaki; Kobayashi, Akira

    2015-08-01

    Accumulating evidence indicates that the vertebrate stress-response transcription factors Nrf1 and Nrf2 are involved in hepatic lipid metabolism. However, the underlying molecular mechanisms of Nrf1-and Nrf2-mediated lipid metabolism remain unclear. To elucidate the precise roles of Nrfs in this process, we analyzed the physiological role of CncC in lipid metabolism as a Drosophila model for vertebrate Nrf1 and Nrf2. We first examined whether CncC activity is repressed under physiological conditions through a species-conserved NHB1 (N-terminal homology box 1) domain, similar to that observed for Nrf1. Deletion of the NHB1 domain (CncC?N) led to CncC-mediated rough-eye phenotypes and the induced expression of the CncC target gene gstD1 both in vivo and in vitro. Thus, we decided to explore how CncC?N overexpression affects the formation of the fat body, which is the major lipid storage organ. Intriguingly, CncC?N caused a significant reduction in lipid droplet size and triglyceride (TG) levels in the fat body compared to wild type. We found that CncC?N induced a number of genes related to innate immunity that might have an effect on the regulation of cellular lipid storage. Our study provides new insights into the regulatory mechanism of CncC and its role in lipid homeostasis. PMID:26049108

  7. CNC-implemented fault diagnosis and web-based remote services

    Microsoft Academic Search

    Dong-Hoon Kim; Sun-Ho Kim; Kwang-Sik Koh

    2005-01-01

    Recently, the conventional controller of machine-tool has been increasingly replaced by the PC-based open architecture controller,\\u000a which is independent of the CNC vendor and on which it is possible to implement user-defined application programs. This paper\\u000a proposes CNC-implemented fault diagnosis and web-based remote services for machine-tool with open architecture CNC. The faults\\u000a of CNC machine-tool are defined as the operational

  8. Resonance line of B II in IUE spectra of chemically peculiar stars

    SciTech Connect

    Leckrone, D.S.

    1981-11-15

    High-dispersion IUE spectroscopic observations of the B II resonance line at 1362.46 A are presented for six HgMn stars (kappa Cnc, ..mu.. Lep, 46 Draiola, CrB, HR 4072, and chi Lup), two magnetic peculiar stars (..cap alpha../sup 2/ CVn and HD 32633), and one normal B9.5 V star (..nu.. Cap). The B II line is present in great strength in kappa Cnc. It is absent from the five other HgMn stars. It is probably present, though unresolved and weak, in the magnetic stars. Its strength in ..nu.. Cap is consistent with a normal boron abundance.

  9. o Consonant-Nucleus-Consonant (CNC) o 50 phonetically balanced one-syllable words (list phonetically balanced to

    E-print Network

    Litovsky, Ruth

    Stimuli o Consonant-Nucleus-Consonant (CNC) o 50 phonetically balanced one-syllable words (list) as a function of run number METHODS Figure 1: Testing screen consisting of 50 CNC words. Figure 3. Acute adult

  10. Command Shaping for Micro-Mills and CNC Controllers Joel Fortgang*, William Singhose*, Juan de Juanes Marquez**, Jesus Perez**

    E-print Network

    Singhose, William

    Command Shaping for Micro-Mills and CNC Controllers Joel Fortgang*, William Singhose*, Juan de-mill which can be implemented with a standard CNC controller. The robustness of this technique to modelling

  11. Prediction of the final part properties in sheet metal forming by CNC-controlled stretch forming

    Microsoft Academic Search

    K. Siegert; A. Rennet; K.-J. Fann

    1997-01-01

    By means of the finite element method (FEM) stimulation it was possible to predetermine the final properties of sheet metal parts which were formed with a CNC-controlled stretch forming machine. The CNC-controlled stretch forming machine allows the formation of convex shaped sheet metal parts with the help of six independent two axes grippers. In the sense of a real process

  12. CNC incremental sheet forming of an axially symmetric specimen and the locus of optimization

    Microsoft Academic Search

    Kun Dai; Z. R Wang; Yi Fang

    2000-01-01

    CNC incremental sheet forming is a new flexible sheet forming process. It does not need a dedicated die and can form sheet parts with a higher forming limit and of complicated shape by use of a CNC device. This process is suited to the forming of sheet parts of small volume, diversification and complicated shape in space-flight, automobile and civil

  13. A generalized approach for the acceleration and deceleration of industrial robots and CNC machine tools

    Microsoft Academic Search

    Jae Wook Jeon; Young Youl Ha

    2000-01-01

    Many techniques for the acceleration and deceleration of industrial robots and computer numerical control (CNC) machine tools have been proposed in order to make industrial robots and CNC machine tools perform given tasks efficiently. Although the techniques selecting polynomial functions can generate various acceleration and deceleration characteristics, the major problem is the computational load. The digital convolution techniques are more

  14. Prediction of surface roughness in CNC face milling using neural networks and Taguchi's design of experiments

    Microsoft Academic Search

    P. G Benardos; G. C Vosniakos

    2002-01-01

    In this paper, a neural network modeling approach is presented for the prediction of surface roughness (Ra) in CNC face milling. The data used for the training and checking of the networks’ performance derived from experiments conducted on a CNC milling machine according to the principles of Taguchi design of experiments (DoE) method. The factors considered in the experiment were

  15. FPGA based acceleration and deceleration circuit for industrial robots and CNC machine tools

    Microsoft Academic Search

    Jae Wook Jeon; Yun-Ki Kim

    2002-01-01

    In order to make industrial robots and computer numerical control (CNC) machine tools perform tasks efficiently, many techniques for the acceleration and deceleration of industrial robots and CNC machine tools have been proposed. Polynomial technique can generate velocity profiles of various acceleration and deceleration characteristics, but it requires a lot of computations. Digital convolution technique can generate efficiently velocity profiles,

  16. Department of Industrial and Manufacturing Engineering Fall 2012 Enabling CNC-RP in PSU's IE FAME Lab

    E-print Network

    Demirel, Melik C.

    PENNSTATE Department of Industrial and Manufacturing Engineering Fall 2012 Enabling CNC-RP in PSU's IE FAME Lab Overview In this project, CNC-RP capability has been installed and developed in the Penn be built with this particular method. After finding the limitations of this process, this CNC-RP capability

  17. International Conference on E-Portfolio Process in Vocational Education-EPVET 2007 REVISITING CNC TRAINING A "VIRTUAL TRAINING CENTRE

    E-print Network

    Aristomenis, Antoniadis

    International Conference on E-Portfolio Process in Vocational Education- EPVET 2007 REVISITING CNC TRAINING ­ A "VIRTUAL TRAINING CENTRE FOR CNC" Mehmet ahin*1 , Nikolaos Bilalis2 , Süleyman Yaldiz1, Technological Educational Institute of Crete, Chania, Greece Abstract CNC Training has been a scope of interest

  18. FR Cnc Nature Revisited M.C. Galvez, A. Golovin, M. Hernan-Obispo, E. Pavlenko, M. Andreev, D.

    E-print Network

    Complutense de Madrid, Universidad

    FR Cnc Nature Revisited M.C. G´alvez, A. Golovin, M. Hern´an-Obispo, E. Pavlenko, M. Andreev, D and spectroscopic monitoring of FR Cnc re- ported a tricky nature. We carried out several observations at different Cnc in three observing runs: March-April 2004, using the Fibre Optics Cassegrain Echelle Spec

  19. Stars

    NASA Astrophysics Data System (ADS)

    Capelato, Hugo Vicente

    1999-01-01

    We will begin our study with a more or less superficial inspection of the "forest" of stars that we see in the skies. The first thing we notice is that, as sources of light, they are much weaker than the Sun. Second, their apparent colors vary; from a bluish-white in most of them to a reddish-yellow, which is rarer. There is also a third aspect, though it is not very obvious to the naked eye: most of the stars group themselves in small families of two, three or more members. A good example is the Alpha Centauri, the closest star to us, which, in fact, is a triple system of stars. Another is the group of 7 stars that make up the Pleiades, which will be discussed later on. In fact, almost half of the stars are double systems with only two members, called binary stars. Most of these double stars, though together, are separated by several astronomical units (one astronomical unit, AU, is the distance from Earth to the sun: see Chapter 1), and revolve around each other over periods of several years. And yet the revolutions of some binary stars, separated by much smaller distances, occur in only a few hours! These stars are so close to each other that they can share enveloping material. Often this exchange occurs in a somewhat violent manner. Local explosions may occur, expelling matter away from the system. In other binary systems, where one of the components is a very compact, dense star, companion material flows more calmly, making up a light disk around the compact star.

  20. HI Observations of the Asymptotic Giant Branch Star X Herculis: Discovery of an Extended Circumstellar Wake Superposed on a Compact High-Velocity Cloud

    E-print Network

    Matthews, L D; Gerard, E; Bertre, T Le; Johnson, M C; Dame, T M

    2010-01-01

    We report HI 21-cm line observations of the AGB star X Her obtained with the Green Bank Telescope (GBT) and the Very Large Array (VLA). We have detected HI emission totaling M_HI=2.1e-03 M_sun associated with the circumstellar envelope of the star. The HI distribution exhibits a head-tail morphology, similar to those previously observed around Mira and RS Cnc. The tail extends ~6.0' (0.24 pc) in the plane of the sky, along the direction of the star's space motion. We also detect a velocity gradient of ~6.5 km/s across the envelope, consistent with the HI tracing a turbulent wake that arises from the motion of a mass-losing star through the ISM. GBT mapping of a 2x2deg region around X Her reveals that the star lies (in projection) near the periphery of a much larger HI cloud that also exhibits signatures of ISM interaction. The properties of the cloud are consistent with those of compact high-velocity clouds. Using CO observations, we have placed an upper limit on its molecular gas content of N_H22.4~M_sun) an...

  1. Implementation of CAD/CAM/CNC Curriculum Using Mastercam X Software in Technical Programs

    NSDL National Science Digital Library

    Heidari, Farzin

    One of the major contributions to the growing acceptance of Computer Numerical Control (CNC) has been the development of Computer Aided Manufacturing (CAM). A Computer Aided Manufacturing (CAM) program uses a CAD drawing, and then adds the cutting parameters to generate the CNC program. MastercamX is PC-based CAD/CAM software, which integrates the geometry, toolpath, and the G-code program together. The CAD section of the Mastercam software generates a dimensioned drawing using basic entities. The geometry file is saved as a CAD file and then turned into CNC code. The CNC code is used to machine parts on a milling machine. Mastercam software ties the CAD/CAM process together to generate a CNC program to make a part, using a machine tool.

  2. CNC water-jet machining and cutting center

    SciTech Connect

    Bartlett, D.C.

    1991-09-01

    CNC water-jet machining was investigated to determine the potential applications and cost-effectiveness that would result by establishing this capability in the engineering shops of Allied-Signal Inc., Kansas City Division (KCD). Both conductive and nonconductive samples were machined at KCD on conventional machining equipment (a three-axis conversational programmed mill and a wire electrical discharge machine) and on two current-technology water-jet machines at outside vendors. These samples were then inspected, photographed, and evaluated. The current-technology water-jet machines were not as accurate as the conventional equipment. The resolution of the water-jet equipment was only {plus minus}0.005 inch, as compared to {plus minus}0.0002 inch for the conventional equipment. The principal use for CNC water-jet machining would be as follows: Contouring to near finished shape those items made from 300 and 400 series stainless steels, titanium, Inconel, aluminum, glass, or any material whose fabrication tolerance is less than the machine resolution of {plus minus}0.005 inch; and contouring to finished shape those items made from Kevlar, rubber, fiberglass, foam, aluminum, or any material whose fabrication specifications allow the use of a machine with {plus minus}0.005 inch tolerance. Additional applications are possible because there is minimal force generated on the material being cut and because the water-jet cuts without generating dust. 12 figs.

  3. Stars

    NSDL National Science Digital Library

    Roberta Johnson

    2000-07-01

    This section of the Windows to the Universe web site provides information and images about stars including star statistics, and a star gallery. Windows to the Universe is a user-friendly learning system pertaining to the Earth and Space sciences. The objective of this project is to develop an innovative and engaging web site that spans the Earth and Space sciences and includes a rich array of documents, including images, movies, animations, and data sets that explore the Earth and Space sciences and the historical and cultural ties between science, exploration and the human experience. Links at the top of each page allow users to navigate between beginner, intermediate and advanced levels.

  4. Design and performance of a small precision CNC turning machine

    SciTech Connect

    Donaldson, R.R.; Thompson, D.C.

    1986-02-26

    This paper describes the design of a CNC turning machine that is capable of machining workpieces up to 100 mm in diameter with a high contour accuracy and a very low surface roughness. Two nearly identical machines have been built and put into operation using this design, one for serial parts manufacture and the other for research into improving the accuracy of single-point machining; information based on this operational experience is also presented. The first machine has demonstrated an accuracy of 0.1 ..mu..m peak-to-valley on contoured workpieces, while the second machine has produced surface roughnesses of 1 nm rms in flat facing of electroless nickel with a diamond tool.

  5. The moderately interacting Algol binary RS Cephei

    NASA Technical Reports Server (NTRS)

    Plavec, Mirek J.; Dobias, Jan J.

    1987-01-01

    In agreement with previous observers, it is found that the eclipsing binary RS Cep is an Algol-type semidetached system. From IUE spectra and Lick Observatory optical scans, the spectral types of the components are determined as B9.7e V + G8 III-IV. The effective temperature of the primary star is found to be 9670 K (with an uncertainty of about 150 K). From the photometric elements, the spectral types, and the semidetached nature of the system, a satisfactory model of the system is developed, giving masses 2.4 and 0.4 solar mass, radii 2.3 and 7.6 solar radii, and separation of the components 32 solar radii. This model leads to a distance of 910 pc; the color excess is E(B - V) = 0.03 mag. Balmer emission lines are observed in the optical scans, so that the system is a Be star. An IUE spectrum obtained during the total primary eclipse reveals a number of UV emission lines, typical for interacting Algols and W Ser stars. Power emitted in these lines is about twice as high as that in TT Hya or U Cep, therefore, RS Cep is a relatively active Algol system. A broad 'bulge' of excess relative flux is observed roughly between wavelengths 210 and 270 nm in the totality spectrum, and interpreted as broad blends of emission lines of Fe II; the same Fe II lines, formed in a circumstellar shell or disk, cause additional absorption in the out-of-eclipse spectra.

  6. STEPNC++ – An Effective Tool for Feature-based CAM\\/CNC

    Microsoft Academic Search

    John Michaloski; Thomas Kramer; Frederick Proctor; Xun Xu; Sid Venkatesh; David Odendahl

    This chapter discusses the realization of direct translation of feature-based CAM files into feature-based CNC part program\\u000a files. The information infrastructure that allows this to happen is STEP-NC, as described by ISO 14649 Parts 10 and 11. Among\\u000a the many benefits cited for STEP-NC, the elimination of the costly and inefficient process of post-processing using one standard\\u000a CNC definition is

  7. Machining of plate cam profiles on CNC machine tools using a highly integrated part programming system

    Microsoft Academic Search

    B. Satyanarayana; P. N. Rao; N. K. Tewari

    1988-01-01

    The concept of NC (Numerical Control) and CNC (Computerised Numerical Control) in machine tools has contributed a great deal\\u000a to automation and flexibility in manufacturing. In small\\/medium batch manufacturing, machining of complex contours with conventional\\u000a machining is neither economical nor accurate. These can be achieved on a CNC machining centre more economically.\\u000a \\u000a The can machining system is designed to provide

  8. Hierarchical real-time networked CNC system based on the transparent model of industrial Ethernet

    Microsoft Academic Search

    X. L. Zhang; X. Q. Tang; J. H. Chen; H. C. Zhou; T. Wu

    2007-01-01

    Given the rising importance of industrial Ethernet in the market, a networked CNC (Computer Numerical Control) system based\\u000a on the transparent model of industrial Ethernet is urgently needed. To this end, a hierarchical real-time network based on\\u000a Ethernet\\/Internet, called RNH-CNC, is designed in this paper. To evaluate the performance, some experiments were conducted\\u000a and the results were analyzed. The results

  9. Springback behaviour in bending of ultra-high-strength steel sheets using CNC servo press

    Microsoft Academic Search

    K. Mori; K. Akita; Y. Abe

    2007-01-01

    The springback behaviour of ultra-high-strength steel sheets in bending was investigated under controlled conditions using a CNC servo press. Although the ultra-high-strength steel sheets are attractive in reducing weight of cars, the amount of springback of the ultra-high-strength steel sheets in the forming is very large due to high strength. The CNC servo press has the function of accurately controlling

  10. An investigation of stick-slip friction on the contouring accuracy of cnc machine tools

    Microsoft Academic Search

    Y. S. Tarng; H. E. Cheng

    1995-01-01

    Stick-slip friction has a great influence on the contouring accuracy of CNC machine tools. In this paper, a nonlinear model is used to simulate and analyze dynamic behaviors of stick-slip friction on the contouring accuracy of CNC machine tools. A simple control strategy is then developed to tune the control loop gain for reducing the contouring error due to stick-slip

  11. Identification of common sensory features for the control of CNC milling operations under varying cutting conditions

    Microsoft Academic Search

    Yalcin M. Ertekin; Yongjin Kwon

    2003-01-01

    The main focus of this study is to identify the most influential and common sensory features for the process quality characteristics in CNC milling operations—dimensional accuracy (bore size tolerance) and surface roughness—using three different material types (6061-T6 aluminum, 7075-T6 aluminum, and ANSI-4140 steel). The materials were machined on a vertical CNC mill, retrofitted with multiple sensors and data acquisition systems,

  12. Cellulose nanocrystals (CNC) as carriers for a spirooxazine dye and its effect on photochromic efficiency.

    PubMed

    Sun, Bo; Hou, Qingxi; He, Zhibin; Liu, Zehua; Ni, Yonghao

    2014-10-13

    Nanocrystalline cellulose (CNC) as a renewable/sustainable material, has received much attention. Herein we studied CNC as carriers for a hydrophobic spirooxazine (SO)-based dye, 1,3-dihydro-1,3,3-trimethylspiro[2H-indole-2,3'-[3H]naphtha[2,1-b][1,4]oxazine], which may have potential applications in reversible memory photo-devices, textiles, photo-sensitive paper coatings, and inkjet printing inks. Due to the high cost and water-insolubility of this dye, it is desirable to improve its coloration efficiency and water-dispersibility. The experimental approach was to use CNC as carriers for the SO dye, thus obtaining a stable photochromic dye in aqueous systems. Transmission electron microscope (TEM) observation confirmed that the SO dye adsorbed on the surface of the CNC, which functioned as carriers for the photochromic dye. An impregnation process was adopted to anchor the dye onto cellulosic paper. It was found that the use of CNC resulted in a significant improvement in the SO coloration efficiency. The color stability and fatigue resistance were also studied. The use of CNC as carriers for a hydrophobic compound, its enhancement of associated properties, and its subsequent application were demonstrated. PMID:25037370

  13. CNC programming system for complex components based on KBE within integrated environment of CAD\\/CAPP\\/CAM

    Microsoft Academic Search

    Shengwen Zhang; Guicheng Wang; Liang Zhang; Xifeng Fang

    2009-01-01

    To promote the research and development of modern digital and intelligent manufacturing technology and overcome shortcomings\\u000a of computerized numerical control(CNC) programming for complex components, an innovative idea has been proposed to introduce\\u000a knowledge based engineering (KBE) into the field of CNC programming within the integrated environment of CAD\\/CAPP\\/ CAM. This\\u000a paper constructs the architecture of CNC programming based on KBE

  14. PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese.

    PubMed

    Sjakste, Tatjana; Paramonova, Natalia; Wu, Lawrence Shi-Shin; Zemeckiene, Zivile; Sitkauskiene, Brigita; Sakalauskas, Raimundas; Wang, Jiu-Yao; Sjakste, Nikolajs

    2014-12-01

    PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity was investigated in 1438 unrelated subjects from Latvia, Lithuania and Taiwan. In general, polymorphism of each individual locus showed tendencies similar to determined previously in HapMap populations. Main differences concern Taiwanese and include presence of rs2277460 rare allele A not found before in Asians and absence of rs2295827 rare alleles homozygotes TT observed in all other human populations. Observed patterns of SNPs and haplotype diversity were compatible with expectation of neutral model of evolution. Linkage disequilibrium between the rs2295826 and rs2295827 was detected to be complete in Latvians and Lithuanians (D? = 1; r(2) = 1) and slightly disrupted in Taiwanese (D? = 0.978; r(2) = 0.901). Population differentiation (FST statistics) was estimated from pairwise population comparisons of loci variability, five locus haplotypes and PSMA6 and PSMC6 two locus haplotypes. Latvians were significantly different from all Asians at each of 5 SNPs and from Lithuanians at the rs1048990 and PSMC6 loci. Lithuanian and Asian populations exhibited similarities at the PSMC6 loci and were different at the PSMA6 and PSMA3 SNPs. Considering five locus haplotypes all European populations were significantly different from Asian; Lithuanian population was different from both Latvian and CEU. Allele specific patterns of transcription factor binding sites and splicing signals were predicted in silico and addressed to eventual functionality of nucleotide substitutions and their potential to be involved in human genome evolution and geographical adaptation. Current study represents a novel step toward a systematic analysis of the proteasomal gene genetic diversity in human populations. PMID:25606411

  15. RS3PE: Clinical and Research Development.

    PubMed

    Li, Hongbin; Altman, Roy D; Yao, Qingping

    2015-08-01

    Remitting seronegative symmetrical synovitis with pitting edema or RS3PE is a rare elderly-onset rheumatic syndrome. Although there are overlapping clinical manifestations between RS3PE, elderly-onset rheumatoid arthritis, and polymyalgia rheumatica, RS3PE has distinct characteristics. RS3PE can be associated with neoplasia and various rheumatic conditions, suggesting that it may be heterogeneous, and is considered as a paraneoplastic rheumatic disease. The pathogenesis of RS3PE may involve vascular endothelial growth factor and infection in RS3PE based upon limited data. Patients with RS3PE without concomitant malignancy respond well to small doses of glucocorticoids and carry good prognosis. PMID:26113011

  16. The Design of Free Surface Interpolator for CNC Machining

    NASA Astrophysics Data System (ADS)

    Tseng, Pai-Chung; Hon, Jung-Yong

    This article provides a design for the real-time interpolator of the B-Spline free surface. The goal is to increase both the accuracy and the speed of manufacturing production by eliminating the bottleneck caused by the off-line interpolator of the CNC tool machines, by reducing manufacturing errors, and by resolving the issue of long numeric control code (NC code). The design of the surface interpolator includes location planning using the real-time cutter contact data, the interpolation of the cutter contact data, and the cutting compensation of the cutter location data. This paper provides a surface interpolation method for reading the surface NC code of a three-dimensional surface and for implementing the surface interpolation. To simplify the complexity of the calculation, one can first use knot interpolation to decompose the B-Spline surface into sections of Bezier surface, which are then used as the surface for real-time surface interpolation. Subsequently, the approximation of the second order Taylor expansion is used to obtain the location interpolation points. Fixed machining parameters are adopted to avoid the low efficiency and low quality of manufacturing caused by variation of the feeding speed. The derived cutting locations are further combined to obtain the cutting locations of the original B-Spline surface. The verification of the experiments is shown with comparing the manufacturing profile errors and any variation of the feeding speed derived from computer simulation and the corresponding data obtained from the off-line interpolators.

  17. Continuous tone printing in silicone from CNC milled matrices

    NASA Astrophysics Data System (ADS)

    Hoskins, S.; McCallion, P.

    2014-02-01

    Current research at the Centre for Fine Print Research (CFPR) at the University of the West of England, Bristol, is exploring the potential of creating coloured pictorial imagery from a continuous tone relief surface. To create the printing matrices the research team have been using CNC milled images where the height of the relief image is dictated by creating a tone curve and then milling this curve into a series of relief blocks from which the image is cast in a silicone ink. A translucent image is cast from each of the colour matrices and each colour is assembled - one on top of another - resulting is a colour continuous tone print, where colour tone is created by physical depth of colour. This process is a contemporary method of continuous tone colour printing based upon the Nineteenth Century black and white printing process of Woodburytype as developed by Walter Bentley Woodbury in 1865. Woodburytype is the only true continuous tone printing process invented, and although its delicate and subtle surfaces surpassed all other printing methods at the time. The process died out in the late nineteenth century as more expedient and cost effective methods of printing prevailed. New research at CFPR builds upon previous research that combines 19th Century Photomechanical techniques with digital technology to reappraise the potential of these processes.

  18. The design of an ultra-precision CNC measuring machine

    SciTech Connect

    Thompson, D.C.

    1989-01-01

    A specialized ultra-precision CNC measuring machine is being developed to provide an inspection capability compatible with existing precision turning machines. The instrument is to be applied to the inspection of the inner and outer surfaces of hemispherical shells and other axisymmetric parts, with diameters of up to 400 mm. The overall accuracy of the machine operating in continuous path contouring mode is to be less than 0.75 micrometre (p-v) per surface, including both instrument and process-related errors. In addition, an accuracy of 1.75 micrometres is required for the inspection of wall thickness on some categories of parts, which in some instances may be distorted by gravity loading. This latter requirement dictates a single setup for the inspection of inner and outer surfaces, and effectively eliminates a standard Coordinate Measuring Machine (CMM) configuration for the new gauge. The new instrument is known as the Certification of Process (COP) Gauge. 9 refs., 5 figs., 2 tabs.

  19. 57ime CONGRS CANADIEN DE GOTECHNIQUE 57TH CANADIAN GEOTECHNICAL CONFERENCE 5ime CONGRS CONJOINT SCG/AIH-CNN 5TH JOINT CGS/IAH-CNC CONFERENCE

    E-print Network

    Aubertin, Michel

    CONJOINT SCG/AIH-CNN 5TH JOINT CGS/IAH-CNC CONFERENCE GENERALIZED DIRECTIONAL PEAK SHEAR STRESS CRITERION résistance au cisaillement des joints cisaillés à contrainte normale constante (CNC) ou à rigidité normale

  20. Synthesis of chemical cross-linked gelatin hydrogel reinforced with cellulose nanocrystals (CNC)

    NASA Astrophysics Data System (ADS)

    Yin, Ooi Shok; Ahmad, Ishak; Amin, Mohd. Cairul Iqbal Mohd

    2014-09-01

    A novel method was performed to obtain hydrogel with superior sensitivity towards changes in pH and temperature by incorporation of CNC into gelatin based hydrogel. Glutaraldehyde was used as cross-linker due to its high chemical reactivity towards NH2 group on gelatin. Different ratio of gelatin / CNC hydrogel was produced in order to study the effects of CNC towards the swelling behaviour of hydrogel at different pH and temperature. Swelling tests were performed at different pH range from pH 3 to pH 11. Temperature swelling tests were performed at 25 °C and 37 °C. The hydrogel showed impressive pH sensitivity and maximum swelling was obtained at pH 3. Higher swelling ratio was observed at higher temperature. SEM micrographs showed that the pore size of hydrogel decreased with increasing CNC content due to formation of more rigid hydrogel structure. The characteristics of the hydrogel to respond to different pH and temperature suggest that gelatin / CNC hydrogel are promising candidates to be developed as drug carrier.

  1. STAR Highlights and Future Brookhaven National Laboratory

    E-print Network

    STAR Highlights and Future Brookhaven National Laboratory May 5th , 2008 S T A RS T A R RR. Sponsored by the Department of Physics, Brookhaven National Laboratory #12;STAR Highlights and Future Brookhaven National Laboratory May 5th , 2008 S T A RS T A R RR Scientific Program 2:00 pm Opening Remarks

  2. 76 FR 39156 - C&NC Railroad, LLC-Lease Renewal Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ...Beesons, Ind., to milepost 25.30 at New Castle, Ind., and (b) milepost R0.1 to milepost R1.16 at New Castle. C&NC has leased and operated the lines...the interchange point with NSR is New Castle. C&NC certifies that the...

  3. 9th Biannual Joint Technical Day of CIE/USA and CNC/CIE, Davis, CA, 7 Nov. 2013 Improving Traceability of

    E-print Network

    California at Davis, University of

    9th Biannual Joint Technical Day of CIE/USA and CNC/CIE, Davis, CA, 7 Nov. 2013 Improving/CIE and CNC/CIE Technical Day 7 November 2013 Joanne Zwinkels, William Neil and Mario Noël Measurement Science and Standards National Research Council of Canada #12;9th Biannual Joint Technical Day of CIE/USA and CNC

  4. INT. J. PROD.RES.,2000, VOL.38, NO. 7, 1677 1687 CNC tool path planning for multi-patch sculptured surfaces

    E-print Network

    Kim, Jongwon

    INT. J. PROD.RES.,2000, VOL.38, NO. 7, 1677± 1687 CNC tool path planning for multi-patch sculptured surfaces J. H. CHO{, J. W. KIM{ and K. KIM}* A new CNC tool path generation method for a multi representation methods in the CAD system, the next step is to obtain CNC tool paths (CL ® le) for the given

  5. **Notice of Job Opportunity: Reynolds Manufacturing Company ** Reynolds Manufacturing company is looking for a CNC Programmer and Set up person. For details see

    E-print Network

    Saniie, Jafar

    is looking for a CNC Programmer and Set up person. For details see the listing below. Interested students Company larrym@reynoldsmfg.com Job Title: CNC programmer / set up company Name: Reynolds Website URL: reynoldsmfg.com Qualifications: Manufacturing company in Milan, Illinois is seeking a CNC

  6. An iterative learning control method with application for CNC machine tools

    SciTech Connect

    Kim, D.I.; Kim, S. [Samsung Electronics, Suwon (Korea, Republic of)

    1996-01-01

    A proportional, integral, and derivative (PID) type iterative learning controller is proposed for precise tracking control of industrial robots and computer numerical controller (CNC) machine tools performing repetitive tasks. The convergence of the output error by the proposed learning controller is guaranteed under a certain condition even when the system parameters are not known exactly and unknown external disturbances exist. As the proposed learning controller is repeatedly applied to the industrial robot or the CNC machine tool with the path-dependent repetitive task, the distance difference between the desired path and the actual tracked or machined path, which is one of the most significant factors in the evaluation of control performance, is progressively reduced. The experimental results demonstrate that the proposed learning controller can improve machining accuracy when the CNC machine tool performs repetitive machining tasks.

  7. X-ray observations through the outburst cycle of the dwarf nova YZ Cnc

    E-print Network

    Frank Verbunt; Peter J. Wheatley; Janet A. Mattei

    1999-03-15

    We have observed YZ Cnc at two day intervals from 6 to 24 April 1998, covering two full outburst cycles. The 0.1-2.4 keV flux is lower during optical outburst than in quiescence, and lowest at the end of the outburst. The decline of the X-ray flux in the quiescent interval appears to be in contrast to prediction of simple models for accretion-disk instabilities. Variability on \\~hour time scales is present, but appears not related to the orbital phase. YZ Cnc was less luminous in X-rays during our 1998 observations than in earlier ROSAT observations.

  8. Radio emission of cataclysmic variable stars

    NASA Technical Reports Server (NTRS)

    Fuerst, E.; Benz, A.; Hirth, W.; Geffert, M.; Kiplinger, A.

    1986-01-01

    Eight cataclysmic variable stars were observed at 6 cm wavelength using the Very Large Array (VLA). The objects were: CN-Ori, SS-Aur, YZ-Cnc, SU-Uma, Z-Cam, V603-Aql, EM-Cyg, and RZ-Sge. Most of these objects were in optical high stage, but none were detected beyond flux limits between 0.1 and 0.3 mJy.

  9. Chemical crosslinking of acrylic acid to form biocompatible pH sensitive hydrogel reinforced with cellulose nanocrystals (CNC)

    SciTech Connect

    Lim, Lim Sze; Ahmad, Ishak; Lazim, Mohd Azwani Shah Mat [Faculty of Science and Technology, University Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor (Malaysia); Amin, Mohd. Cairul Iqbal Mohd [Faculty of Pharmacy, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur (Malaysia)

    2014-09-03

    The purpose of this study is to produce a novel pH and temperature sensitive hydrogel, composed of poly(acrylic acid) (PAA) and cellulose nanocrystal (CNC). CNC was extracted from kenaf fiber through a series of alkali and bleaching treatments followed by acid hydrolysis. The PAA was then subjected to chemical cross-linking using the cross-linking agent (N,N-methylenebisacrylamide) with CNC entrapped in PAA matrix. The mixture was casted onto petri dish to obtain disc shape hydrogel. The effects of reaction conditions such as the ratio of PAA and CNC on the swelling behavior of the hydrogel obtained towards pH and temperature were studied. The obtained hydrogel was further subjected to different tests such swelling test for swelling behaviour at different pH and temperature along with scanning electron microscopy (SEM) for morphology analysis. The hydrogel obtained showed excellent pH sensitivity and obtained maximum swelling at pH 7. Besides that, hydrogel obtained showed significant increase in swelling ratio when temperature of swelling medium was increased from 25°C to 37°C. SEM micrograph showed that the pore size of the hydrogel decreases with increase of CNC content proving that the hydrogel structure became more rigid with addition of CNC. The PAA/CNC hydrogel with such excellent sensitivity towards pH and temperature can be developed further as drug carrier.

  10. Chemical crosslinking of acrylic acid to form biocompatible pH sensitive hydrogel reinforced with cellulose nanocrystals (CNC)

    NASA Astrophysics Data System (ADS)

    Lim, Lim Sze; Ahmad, Ishak; Lazim, Mohd Azwani Shah Mat; Amin, Mohd. Cairul Iqbal Mohd

    2014-09-01

    The purpose of this study is to produce a novel pH and temperature sensitive hydrogel, composed of poly(acrylic acid) (PAA) and cellulose nanocrystal (CNC). CNC was extracted from kenaf fiber through a series of alkali and bleaching treatments followed by acid hydrolysis. The PAA was then subjected to chemical cross-linking using the cross-linking agent (N,N-methylenebisacrylamide) with CNC entrapped in PAA matrix. The mixture was casted onto petri dish to obtain disc shape hydrogel. The effects of reaction conditions such as the ratio of PAA and CNC on the swelling behavior of the hydrogel obtained towards pH and temperature were studied. The obtained hydrogel was further subjected to different tests such swelling test for swelling behaviour at different pH and temperature along with scanning electron microscopy (SEM) for morphology analysis. The hydrogel obtained showed excellent pH sensitivity and obtained maximum swelling at pH 7. Besides that, hydrogel obtained showed significant increase in swelling ratio when temperature of swelling medium was increased from 25°C to 37°C. SEM micrograph showed that the pore size of the hydrogel decreases with increase of CNC content proving that the hydrogel structure became more rigid with addition of CNC. The PAA/CNC hydrogel with such excellent sensitivity towards pH and temperature can be developed further as drug carrier.

  11. Universal geometric error modeling of the CNC machine tools based on the screw theory

    Microsoft Academic Search

    Wenjie Tian; Baiyan He; Tian Huang

    2010-01-01

    The methods to improve the precision of the CNC (Computerized Numerical Control) machine tools can be classified into two categories: error prevention and error compensation. Error prevention is to improve the precision via high accuracy in manufacturing and assembly. Error compensation is to analyze the source errors that affect on the machining error, to establish the error model and to

  12. Comparison of command language and direct manipulation interfaces for CNC milling machines

    Microsoft Academic Search

    O. F. TORRES-CHAZARO; R. J. BEATON; M. P. DEISENROTH

    1992-01-01

    This paper reports a human factors study comparing the usability of command language and direct manipulation interfaces for computer numerically-controlled (CNC) milling machines. The operator-machine interfaces were assessed in terms of task completion time, operator retention of training knowledge, and subjective preference judgements. Four factors were manipulated in the study: (1) work session (two sessions separated by a one week

  13. Autonomous Coordinate Measurement Planning with Work-in-Progress Measurement for TRUE-CNC

    Microsoft Academic Search

    Hung Ng; Jiancheng Liu; Kazuo Yamazaki; Kazuo Nakanishi; Kazusaku Tezuka; Sun-Kyu Lee

    1998-01-01

    The paper deals with the autonomous programming technology for the high speed coordinate measuring machine (CMM). In order to provide the breakthrough technology to enhance the operability of CMMs to be used for in-line measurement of mechanical parts, a new autonomous programming method which automatically generates a CMM program from the CNC program used for machining of the part is

  14. Basic CNC Operation. Training Workbook [and] Assessment and Training Guide [and] Hands-on Assessment.

    ERIC Educational Resources Information Center

    Anoka-Hennepin Technical Coll., Minneapolis, MN.

    This workbook is intended for students taking a course in basic computer numerical control (CNC) operation that was developed during a project to retrain defense industry workers at risk of job loss or dislocation because of conversion of the defense industry. The workbook contains daily training guides for each of the course's 13 sessions. Among…

  15. A Layerless Additive Manufacturing Process based on CNC Accumulation , Chi Zhou, Jingyuan Lao

    E-print Network

    Chen, Yong

    1/13 A Layerless Additive Manufacturing Process based on CNC Accumulation Yong Chen* , Chi Zhou additive manufacturing processes are layer-based, that is building a physical model layer on additive manufacturing, it is suggested to investigate alternative non-layer based approaches

  16. Computer-aided accuracy enhancement for multi-axis CNC machine tool

    Microsoft Academic Search

    Jenq-Shyong Chen

    1995-01-01

    A computer-aided error compensation scheme has been developed to enhance the accuracy of multi-axis CNC machine tools by compensating for machine geometric and thermal errors in software way. Stationary geometric errors including the coupling effect of linkage errors between machine slides are calibrated off line. Dynamic thermal errors are predicted on line by an artificial neural network model. Because machine

  17. Development of a high-speed CNC cutting machine using linear motors

    Microsoft Academic Search

    Seamus Gordon; Michael T. Hillery

    2005-01-01

    The traditional approach to construct CNC machine tools has been to use rotary drive motors and ballscrews to achieve table motion. Linear motors offer several advantages over this approach, including low inertia, better performance, increased accuracy and reduced complexity. This article describes how a low cost, high-speed cutting machine was built using linear motors in order to conduct machining tests

  18. An iterative learning control method with application for CNC machine tools

    Microsoft Academic Search

    Dong-Il Kim; Sungkwun Kim

    1996-01-01

    A proportional, integral, and derivative (PID) type iterative learning controller is proposed for precise tracking control of industrial robots and computer numerical controller (CNC) machine tools performing repetitive tasks. The convergence of the output error by the proposed learning controller is guaranteed under a certain condition even when the system parameters are not known exactly and unknown external disturbances exist.

  19. Statistical optimization and assessment of a thermal error model for CNC machine tools

    Microsoft Academic Search

    Jin-Hyeon Lee; Seung-Han Yang

    2002-01-01

    The objective of a thermal error compensation system for CNC machine tools is improved machining accuracy through real time error compensation. The compensation capability depends on the accuracy of the thermal error model. A thermal error model can be obtained using an appropriate combination of temperature variables. In this study, the thermal error modeling is based on a correlation grouping

  20. A new type of machine control system to replace traditional CNC

    Microsoft Academic Search

    Andrew M. Luscombe; Dario J. Toncich; William Thompson; Richard Dluzniak

    1994-01-01

    This paper discusses the rationale behind a new form of machine tool control system which has been developed at the Key Centre for Computer Integrated Manufacture (CIM Centre) in Melbourne Australia. The new control system is based upon standard computer hardware and is intended as a replacement for computer numerical control (CNC), which has severe limitations in the CIM environment.

  1. Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

    Microsoft Academic Search

    Hozumi Motohashi; Tania O'Connor; Fumiki Katsuoka; James Douglas Engel; Masayuki Yamamoto

    2002-01-01

    Recent progress in the analysis of transcriptional regulation has revealed the presence of an exquisite functional network comprising the Maf and Cap ’n’ collar (CNC) families of regulatory proteins, many of which have been isolated. Among Maf factors, large Maf proteins are important in the regulation of embryonic development and cell differentiation, whereas small Maf proteins serve as obligatory heterodimeric

  2. CNC Turning Center Operations and Prove Out. Computer Numerical Control Operator/Programmer. 444-334.

    ERIC Educational Resources Information Center

    Skowronski, Steven D.

    This student guide provides materials for a course designed to instruct the student in the recommended procedures used when setting up tooling and verifying part programs for a two-axis computer numerical control (CNC) turning center. The course consists of seven units. Unit 1 discusses course content and reviews and demonstrates set-up procedures…

  3. Technical and Symbolic Knowledge in CNC Machining: A Study of Technical Workers of Different Backgrounds.

    ERIC Educational Resources Information Center

    Martin, Laura M. W.; Beach, King

    Performances of 45 individuals with varying degrees of formal and informal training in machining and programming were compared on tasks designed to tap intellectual changes that may occur with the introduction of computer numerical control (CNC). Participants--30 machinists, 8 machine operators, and 7 engineers--were asked background questions and…

  4. Design and manufacture of a CNC desktop lathe for use in a project-based class

    E-print Network

    Hsieh, Jonathan C

    2008-01-01

    The objective of this project is to evolve the design of a CNC desktop lathe for use in a project-based class and then fabricate a prototype to confirm the functionality of the design. This iteration of the lathe effectively ...

  5. A comprehensive method for calibration of volumetric positioning accuracy of CNC-machines

    Microsoft Academic Search

    Eung-Suk Leer; Suk-Hwan Suh; Jin-Wook Shon

    1998-01-01

    A comprehensive method for measuring the systematic errors of CNC-machine tools has been studied. The method used for measurement and calibration of machine tool errors should be general and efficient. The objectives of this study include:1.Volumetric error modelling.2.Experimental procedure for error measurement.3.A tool position and path compensation method.4.The verification method.

  6. CCD Photometric Study of the Contact Binary TX Cnc in the Young Open Cluster NGC 2632

    E-print Network

    Liang, Liu; Soonthornthum, BOONRUCKSAR; Liying, Zhu; Jiajia, He; Yuan, J -Z

    2011-01-01

    TX Cnc is a member of the young open cluster NGC 2632. In the present paper, four CCD epochs of light minimum and a complete V light curve of TX Cnc are presented. A period investigation based on all available photoelectric or CCD data showed that it is found to be superimposed on a long-term increase ($dP/dt=+3.97\\times{10^{-8}}$\\,days/year), and a weak evidence suggests that it includes a small-amplitude period oscillation ($A_3=0.^{d}0028$; $T_3=26.6\\,years$). The light curves in the V band obtained in 2004 were analyzed with the 2003 version of the W-D code. It was shown that TX Cnc is an overcontact binary system with a degree of contact factor $f=24.8%(\\pm0.9%)$. The absolute parameters of the system were calculated: $M_1=1.319\\pm0.007M_{\\odot}$, $M_2=0.600\\pm0.01M_{\\odot}$; $R_1=1.28\\pm0.19R_{\\odot}$, $R_2=0.91\\pm0.13R_{\\odot}$. TX Cnc may be on the TRO-controlled stage of the evolutionary scheme proposed by Qian (2001a, b; 2003a), and may contains an invisible tertiary component ($m_3\\approx0.097M_{\\o...

  7. High speed CNC system design. Part II: modeling and identification of feed drives

    Microsoft Academic Search

    Kaan Erkorkmaz; Yusuf Altintas

    2001-01-01

    Accurate modeling and identification of the feed drives' dynamics is an important step in designing a high performance CNC. This paper presents a method for identifying the dynamic parameters, as well as the friction characteristics of machine tool drives. The inertia and viscous friction are estimated through an unbiased least squares scheme. The friction model is developed by observing the

  8. A real-time NURBS surface interpolator for precision three-axis CNC machining

    Microsoft Academic Search

    M.-C. Tsai; C.-W. Cheng; M.-Y. Cheng

    2003-01-01

    Due to the fact that the cutting occurs around the cutter contact (CC) point, the efficiency and quality of CNC machining can be improved significantly if the CC velocity along the surface is kept costant. Conventional approaches to machining mainly maintain a constant cutter location (CL) velocity, so that the CC velocity along the surface is often not constant and

  9. A real-time scheme of cubic parametric curve interpolations for CNC systems

    Microsoft Academic Search

    Behnam Bahr; Xiaomao Xiao; Krishnan Krishnan

    2001-01-01

    In this paper, the popular finite forward differencing algorithm for fast evaluation of points on a cubic parametric curve is modified for its application to CNC systems so that the inherent accumulative error in the calculation of one piece of curve will not propagate to the whole composite curve. Using specified tolerances, a computationally non-intensive method of analysis for the

  10. Frame based system combination and a comparison with weighted ROVER and CNC

    Microsoft Academic Search

    Björn Hoffmeister; Tobias Klein; Ralf Schlüter; Hermann Ney

    2006-01-01

    In this paper we present a novel ASR system combination technique able to combine systems producing word graphs of dif- ferent structure and with different segmentations. The new method is based on the definition of a time frame-wise word error cost function in a minimum Bayes risk framework. In contrast to confusion network combination (CNC), it preserves both the word

  11. PC-BASED LOW-COST CNC AUTOMATION OF PLASMA PROFILE CUTTING OF PIPES

    Microsoft Academic Search

    James N. Keraita; Kyo-Hyoung Kim

    In modern fabrication shops, it is important to invest in affordable, state-of-the-art technology; including material handling systems, computerized motion control, advanced cutting systems and dedicated software programs in order to compete effectively in the market. In pipe profile cutting operations using plasma arc, CNC automation introduces higher precision, repeatability and speed. One method of simplifying the automation and hence improving

  12. RS-232 Data Diode Tutorial and Reference Manual

    E-print Network

    Jones, Douglas W.

    RS-232 Data Diode Tutorial and Reference Manual DRAFTDRAFTDRAFTDRAFTDRAFTDRAFTDRAFTDRAFTDRAFTDRAFT-232 Data Diode . . . . . . 1 Cables . . . . . . . . . . 2 Signal Definitions for the DB9 RS-232 the RS-232 Data Diode . . . . . . . 5 The RS-232 Data Diode Transmitter . . . . . . 6 Transmitter

  13. UVBY Photometry of the Magnetic Chemically Peculiar Stars HR 1297, 36 Aurigae, and HR 2722 and the Nonmagnetic Chemically Peculiar Stars HR 1576 and alpha CANCRI

    NASA Astrophysics Data System (ADS)

    Adelman, Saul J.; Brunhouse, Eric F.

    1998-11-01

    Differential Strömgren uvby photometric observations from the Four College Automated Photoelectric Telescope are presented for the magnetic CP stars HR 1297, 36 Aur, and HR 2722 and the nonmagnetic CP stars HR 1576 and alpha Cnc. Both the moderately rotating HR 1576, a mercury-manganese star, and alpha Cnc, a metallic-line star, are nonvariable. For HR 1297 we refined Winzer's period to 1.06457 days. Our period of 14.366 days for 36 Aur is an alias of Winzer's period and is in keeping with the sharp-lined nature of this star. We found a more accurate period of 2.31523 days for the low-amplitude variable HR 2722.

  14. Rotational modulation and flares on RS CVn and BY Dra-type stars. I - Photometry and spot models for BY Dra, AU Mic, AR Lac, II Peg and V 711 Tau (= HR 1099)

    NASA Technical Reports Server (NTRS)

    Rodono, M.; Cutispoto, G.; Pazzani, V.; Catalano, S.; Byrne, P. B.

    1986-01-01

    Multicolor wide-band photometry of five active stars is presented. The observations were carried out at several places before, during and after the period of IUE observations for the purpose of determining the location, sizes, and evolution of photospheric spots at the time when chromospheric, transition region, and coronal activity data were obtained from UV and radio observations. II Peg, BY Dra, and AU Mic show fairly stable quasi-sinusoidal light curves, while AR Lac and V 711 Tau show double-peaked light curves. For V 711 Tau, a remarkable evolution of the spotted area extent and/or longitude distribution is found. Small, but definite color variations that are consistent with the cool spot hypothesis have also been detected for BY Dra, II Peg and V 711 Tau.

  15. The Coherent Radio Emission from the RS CVn Binary HR 1099 O. B. SleeA,C

    E-print Network

    The Coherent Radio Emission from the RS CVn Binary HR 1099 O. B. SleeA,C , W. LawsonA , G. Ramsay of radiation which has been emitted at the fundamental electron cyclotron frequency. If the auroral analogue at times of enhanced radio activity in HR 1099. Keywords: Stars: activity -- stars: individual: HR 1099

  16. Integrated steepest-directed and iso-cusped toolpath generation for three-axis CNC machining of sculptured parts

    Microsoft Academic Search

    G. W Vickers; Z Dong

    2003-01-01

    Today, sculptured parts are widely used in aeronautical, automotive, and many other industries. To make high-quality sculptured surfaces through efficient toolpaths in three-axis CNC machining is a major technical challenge. In this work, a new toolpath generation method for three-axis CNC milling, the Steepest-Directed and Iso-Cusped (SDIC) toolpath generation scheme, is introduced. The method integrates the steepest-directed and iso-cusped toolpaths

  17. A Three Dimensional Picture of RS CVN Stellar Atmospheres

    NASA Astrophysics Data System (ADS)

    Linsky, Jeffrey L.

    The ROSAT all-sky survey provides a unique opportunity to study an RS CVn system simultaneously at x-ray, EUV, UV, optical, and radio wavelengths at many phases throughout an orbital period. ROSAT can detect the x-ray flux of each candidate system during each 30 second viewing 16 times per day for at least 2 days. We request a block of 7 IUE shifts to obtain NEAR SIMULTANEOUS emission line fluxes (SWP-LO) and Mg IT line profiles (LWP-HI), and we will obtain contemporaneous optical photometry and spectroscopy and VLA radio fluxes (3.6, 6, and 20 cm). one objective of this PROPOSAL is to obtain the FIRST 3-D MODEL OF THE INHOMOGENEOUS PHOTOSPHERE, CHROMOSPHERE, AND CORONA OF A STAR OTHER THAN THE SUN. We will use optical photometry and spectroscopy to map the spotted photospheres of each star, and the Mg II line profiles to DOPPLERIMAGE their chromospheres, to determine the location, size, and surface flux of the active regions. We will then use the time variation of the UV emission line and x-ray fluxes to determine what fluxes are due to the quiet and active regions separately. These data will provide SURFACE FLUXES for the quiet and active regions separately. We will then will model BOTH REGIONS independently using an emission measure analysis. We will also model any flares observed. The second part of the program will be a simultaneous UV/X-ray SURVEY with the objective of DETERMINING THE RANGE OF PHYSICAL MODELS APPLICABLE TO THE CHROMOSPHERES AND CORONAE OF RS CVN SYSTEMS. We propose to obtain emission line fluxes (SWP-LO) and Mg II line profiles (LWP-HI) of all bright RS CVns observed by ROSAT from mid-July through September 1990 that meet the IUE observing constraints. About 17 systems in the Strassmeier catalog will likely be observed during this period. While many RS CVn systems have been observed separately by IUE and x-ray satellites, SIMULTANEOUS UV and x-ray observations are required to model these spatially inhomogenous and timevariable systems. This research program and the ROSAT RS CVn survey will constitute most of the data for the Ph.D. Thesis of the Lead Investigator, Anthony Veale.

  18. An Upper Limit to the Mass of rho1 Cnc's Radial Velocity Companion

    E-print Network

    Melissa A. McGrath; Edmund Nelan; David C. Black; George Gatewood; Keith Noll; Al Schultz; Stephen Lubow; Inwoo Han; Tomasz F. Stepinski; Thomas Targett

    2001-12-03

    Doppler spectroscopy of rho1 Cnc has detected evidence of a companion with an orbital period of 14.65 days and a minimum mass of 0.88 Jupiter masses. Astrometric observations performed with the Hubble Space Telescope Fine Guidance Sensor 1r using a novel new observing technique have placed an upper limit on the astrometric reflex motion of rho1 Cnc in a time period of only one month. These observations detected no reflex motion induced by the 14.65 day period radial velocity companion, allowing us to place a 3-sigma upper limit of \\~0.3 milliarcseconds on the semi-major axis of this motion, ruling out the preliminary Hipparcos value of 1.15 milliarcseconds. The corresponding upper limit on the true mass of the companion is ~30 Mj, confirming that it is a sub-stellar object.

  19. Vision-based on-machine measurement for CNC machine tool

    NASA Astrophysics Data System (ADS)

    Xia, Ruixue; Han, Jiang; Lu, Rongsheng; Xia, Lian

    2015-02-01

    A vision-based on-machine measurement system (OMM) was developed to improve manufacturing effectiveness. It was based on a visual probe to enable the CNC machine tool itself to act as a coordinate measuring machine (CMM) to inspect a workpiece. The proposed OMM system was composed of a visual probe and two software modules: computer-aided inspection planning (CAIP) module and measurement data processing (MDP) module. The auto-focus function of the visual probe was realized by using astigmatic method. The CAIP module was developed based on a CAD development platform with Open CASCADE as its kernel. The MDP module includes some algorithms for determination of inspection parameters, for example, the chamfered hole was measured through focus variation. The entire system was consequently verified on a CNC milling machine.

  20. Learning Control: SenseMaking, CNC Machines, and Changes in Vocational Training for Industrial Work

    Microsoft Academic Search

    Boel Berner

    2009-01-01

    The paper explores how novices in school-based vocational training make sense of computerized numerical control (CNC) machines.\\u000a Based on two ethnographic studies in Swedish schools, one from the early 1980s and one from 2006, it analyses change and continuity\\u000a in the cognitive, social, and emotional processes of learning how to become a machine tool operator. What and how students\\u000a learn

  1. The vibration behavior of impeller blades in the five-axis CNC flank milling process

    Microsoft Academic Search

    Kawin Sonthipermpoon; E. Bohez; H. Hasemann; M. Rautenberg

    2010-01-01

    Today, in most cases, impellers of centrifugal compressors are produced by flank milling on five-axis CNC milling machines.\\u000a The complex three-dimensional geometry of the very thin blades consists of ruled surfaces. The flank milling process allows\\u000a a fast production of the impellers and the surface of the blades is of high quality. The limited strength of the very thin\\u000a blades

  2. System integrated product design, CNC programming and postprocessing for three-axis lathes

    Microsoft Academic Search

    Stanislaw Zietarski

    2001-01-01

    New three-axis CNC turning machines have been installed on shop floors of factories in the last few years. Although the machines are still particularly adapted to cylindrical work, they are also used for non-cylindrical machining. The third axis, C or Y, and separately driven, additional milling cutters have eliminated traditional limitations and opened new machining possibilities, i.e. turning and milling

  3. Real-time simulation of 3-axis CNC programs with 3D graphics

    Microsoft Academic Search

    Wenxing Qi; Qingping Xiong; Ming Zhou

    1995-01-01

    The 3-dimensional (3D) graphics realtime simulation is one of the difficult techniques in computer numerical control (CNC) machining. This paper presents the data structure representing the geometric volume. Based on the specification of the machining processes and the property of orthographic projection, we develop the local graphics display method for the dynamic graphics, adopting the front-to-back visible-surface determination algorithm. As

  4. A new high-efficiency error compensation system for CNC multi-axis machine tools

    Microsoft Academic Search

    Shih-Ming Wang; Han-Jen Yu; Hung-Wei Liao

    2006-01-01

    To enhance the accuracy of CNC machines for the request of modern industry, an effective static\\/quasi-static error compensation\\u000a system composed of an element-free interpolation algorithm based on the Galerkin method for error prediction, a recursive\\u000a software compensation procedure, and an NC-code converting software, is developed. Through automatically analyzing the machining\\u000a path, the new error prediction method takes into consideration the

  5. Performance analysis of CNC interpolators for time-dependent feedrates along PH curves

    Microsoft Academic Search

    Yi-feng Tsai; Rida T. Farouki; Bryan Feldman

    2001-01-01

    Virtually any desired time variation V(t) of the feedrate along a curved path can be realized by real-time CNC interpolator algorithms for the Pythagorean-hodograph (PH) curves: the only stipulation is that V(t) should admit a closed-form indefinite integral F(t). Different feedrate variations V(t) can be accommodated with minimal modifications to the core algorithm by employing a modular function call to

  6. Five-axis CNC milling for effective machining of sculptured surfaces

    Microsoft Academic Search

    H. D. CHO; Y. T. JUN; M. Y. YANG

    1993-01-01

    In machining of sculptured surfaces on five-axis CNC milling machines, determination of the direction vector of the milling cutter is very important. The direction vector is obtained from the fact that the bottom part of the milling cutter rides on free-form surfaces using a z-map method, and this can be applied to all geometric types of sculptured surfaces. After generating

  7. CNC machine tool surface interpolator for ball-end milling of free-form surfaces

    Microsoft Academic Search

    Chih-Ching Lo

    2000-01-01

    This paper presents a new type of CNC machine tool interpolator that is capable of generating the cutter path for ball-end milling of a free-form surface. The surface interpolator comprises on-line algorithms for cutter-contact (CC) path scheduling, CC path interpolation, and tool offsetting. The interpolator algorithms for iso-parametric, iso-scallop and iso-planar machining methods are developed, respectively. The proposed surface interpolator

  8. Contour machining of free-form surfaces with real-time PH curve CNC interpolators

    Microsoft Academic Search

    Rida T. Farouki; Yi-feng Tsai; Guo-feng Yuan

    1999-01-01

    Two strategies for contour milling of free-form surfaces, using real-time CNC interpolators for Pythagorean-hodograph (PH) curves, are described. The first method, applicable to convex surfaces, employs a flat-end mill and approximates the surface section curves by planar PH quintics. The second approach, which employs a ball-end mill, approximates the tool-center trajectory by quintic PH space curves, and can accommodate nonconvex

  9. Comparison between predicted and actual accuracies for an Ultra-Precision CNC measuring machine

    SciTech Connect

    Thompson, D.C.; Fix, B.L.

    1995-05-30

    At the 1989 CIRP annual meeting, we reported on the design of a specialized, ultra-precision CNC measuring machine, and on the error budget that was developed to guide the design process. In our paper we proposed a combinatorial rule for merging estimated and/or calculated values for all known sources of error, to yield a single overall predicted accuracy for the machine. In this paper we compare our original predictions with measured performance of the completed instrument.

  10. Intelligent cross-coupled fuzzy feedrate controller design for CNC machine tools based on genetic algorithms

    Microsoft Academic Search

    Y. S. Tarng; H. Y. Chuang; W. T. Hsu

    1999-01-01

    In this paper, an intelligent contour control strategy has been investigated to improve the contour error of CNC machine tools. An uncoupled contour control system is first analyzed and then a cross-coupled controller is added in the control loop to form a cross-coupled contour control system. An algorithm for an on-line estimation of the contour error in arbitrary curved contouring

  11. Exact Taylor series coefficients for variable-feedrate CNC curve interpolators

    Microsoft Academic Search

    Rida T. Farouki; Yi-feng Tsai

    2001-01-01

    Abstract Recent papers [Yang DCH, Kong T. Computer Aided Design 1994;26:225?34; Yeh S-S, Hsu P-L. Computer Aided Design 1999;31:349? 57] formulate real-time CNC interpolators for variable feedrates along parametric curves. These interpolators employ,truncated Taylor series to compute successive reference-point parameter values, but in both papers an erroneous coefficient for the highest (quadratic) term is cited. The derivation of the proper

  12. STEP-compliant CNC system for turning: Data model, architecture, and implementation

    Microsoft Academic Search

    Suk-hwan Suh; Dae-hyuck Chung; Byeong-eon Lee; Seungjun Shin; Injun Choi; Kwang-myung Kim

    2006-01-01

    STEP-NC, a new data model for CAD–CAM–CNC chain, is expected to encompass the whole scope of e-manufacturing. The new data model formalized as ISO 14649 is under development by ISO TC184 SC1 and SC4 for the replacement of the old standard so-called G&M codes, formalized as ISO 6983 which has been used since the 1950s. As the new data model

  13. Thread milling on N/C and CNC milling machines. Final report

    SciTech Connect

    Ashbaugh, F.A.; Murry, K.R.

    1985-12-01

    A unique thread-cutting tool design has been developed which permits threading of internal or external features; right- or left-hand threads; and standard, metric, or special pitches within a given size range without changing tools. One of the major advantages of the technique is the ability to produce small threads on N/C and CNC milling manchines. This study presents results showing fabrication of quality threads as small as number 0-80 in selected materials.

  14. Real-time generation and control of cutter path for 5-axis CNC machining

    Microsoft Academic Search

    Chih-Ching Lo

    1999-01-01

    This paper presents a new approach to real-time generation and control of the cutter path for 5-axis machining applications. The cutter path generation method comprises real-time algorithms for cutter-contact path interpolation, cutter offsetting, and coordinate conversion. In addition, a global feedback loop is closed by the CNC interpolator so as to augment the controlled accuracy in practical cutter path generation.

  15. VLT Phase Resolved Optical Spectroscopy of the Ultra-Compact Binary HM Cnc

    E-print Network

    Mason, Elena; Dall'Osso, S; Stella, L; Munari, U; Marconi, G; O'Brian, K; Covino, S; Fugazza, D

    2010-01-01

    A 321.5 s modulation was discovered in 1999 in the X-ray light curve of HM Cnc. In 2001 and 2002, optical photometric and spectroscopic observations revealed that HM Cnc is a very blue object with no intrinsic absorptions but broad (FWHM 1500 km s^-1) low equivalent width emission lines (EW 1-6A), which were first identified with the HeII Pickering series. The combination of X-ray and optical observations pictures HM Cnc as a double degenerate binary hosting two white dwarfs, and possibly being the shortest orbital period binary discovered so far. The present work is aimed at studying the orbital motion of the two components by following the variations of the shape, centroid and intensity of the emission lines through the orbit. In February 2007, we carried out the first phase resolved optical spectroscopic study with the VLT/FORS2 in the High Time Resolution (HIT) mode, yielding five phase bins in the 321 s modulation. Despite the low SNR, the data show that the intensity of the three most prominent emission...

  16. RS CV sub n binary systems

    NASA Technical Reports Server (NTRS)

    Linsky, J. L.

    1984-01-01

    An attempt is made to place in context the vast amount of data obtained as a result of X-ray, ultraviolet, optical, and microwave observations of RS CVn and similar spectroscopic binary systems. Emphasis is on the RS CVn systems and their long period analogs. The following questions are considered: (1) are the original defining characteristics still valid and still adequate? (2) what is the evidence for discrete active regions? (3) have any meaningful physical properties for the atmospheres of RS CVn systems been derived? (4) what do the flare observations tell about magnetic fields in RS CVn systems? (5) is there evidence for systematic trends in RS CVn systems with spectral type?

  17. The Association between Four Genetic Variants in MicroRNAs (rs11614913, rs2910164, rs3746444, rs2292832) and Cancer Risk: Evidence from Published Studies

    PubMed Central

    Cho, William C.; Xu, Yeqiong; Gu, Ling; Nie, Zhenglin; Chen, Liping; Song, Guoqi; Gao, Tianyi; Li, Rui; Wang, Shukui

    2012-01-01

    MicroRNAs (miRNAs) participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. Single nucleotide polymorphisms (SNPs) in miRNA may contribute to cancer development with changes in the microRNA's properties and/or maturation. Polymorphisms in miRNAs have been suggested in predisposition to cancer risk; however, accumulated studies have shown inconsistent conslusionss. To further validate determine whether there is any potential association between the four common SNPs (miR-196a2C>T, rs11614913; miR-146aG>C, rs2910164; miR-499A>G, rs3746444; miR-149C>T, rs2292832) and the risk for developing risk, a meta-analysis was performed according to the 40 published case-control studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the extent of the association. The results demonstrated that the rs11614913TT genotype was significantly associated with a decreased cancer risk, in particular with a decreased risk for colorectal cancer and lung cancer, or for Asian population subgroup. In addition, the rs2910164C allele was associated with decreased risk for esophageal cancer, cervical cancer, prostate cancer, and hepatocellular carcinoma (HCC), in particular in Asian population subgroup. Similarly, the rs3746444G allele was observed as a risk factor for cancers in the Asian population. It is concluded that two SNPs prsent in miRNAs(rs11614913TT, and rs2910164C) may protect against the pathogenesis of some cancers, and that the rs3746444 may increase risk for cancer. PMID:23155448

  18. Systematic Pressure and Temperature Differences between Vaisala RS80 and RS92 Radiosonde-Systems

    NASA Astrophysics Data System (ADS)

    Steinbrecht, W.; Claude, H.; Schönenborn, F.

    2008-12-01

    National meteorological centers are replacing the widely used Vaisala RS80 radiosonde with the newer RS90 or RS92. Such change-overs often introduce erroneous steps into long-term atmospheric temperature records. We show that twin-flight campaigns with RS80 and RS92 sondes on the same balloon, and the transition from RS80 to RS92 in operational radio-soundings over Germany, consistently indicate higher temperature readings from RS92 sondes in the stratosphere. In our presentation we summarize these main differences between RS80 and RS92. Significant differences are found in the stratosphere, above the 100~hPa level. The accuracy of our temperature results is of the order of 0.1 to 0.5~K, and at this level we were not able to find significant differences in the troposphere, although there are indications for slightly higher daytime temperatures from RS92 sondes. During day-time and near 50~hPa, RS92s report +0.3 ± 0.2~K higher temperature than RS80s, increasing to +0.7 ± 0.4~K near 10~hPa (2? uncertainties). At night, the difference is smaller, +0.1 ± 0.1~K near 50~hPa to +0.35 ± 0.2~K near 10~hPa. The mean day-to-night difference (12-00~UT) is also larger for RS92s, by 0.1± 0.06~K near 70~hPa, and by 0.76± 0.16~K near 10~hPa. The main contribution to this stratospheric day-time difference comes from an over-correction of the radiation error in the Vaisala RS80 data processing. The night-time difference at stratospheric levels (and part of the day-time difference) is due to a low bias of the RS80 pressure measurement, typically by -0.4~hPa near 10~hPa. This shifts temperature readings to lower pressure/ higher altitude. For stratospheric levels, it results in lower temperatures from RS80 sondes (due to the vertical temperature increase). Generally, RS92s give better temperature repeatabiliy, ±0.25~K (2?) near 50~hPa, and much more precise pressure, ±0.2~hPa near 50~hPa, compared to RS80 systems, ±0.5~K, or ±1.5~hPa. Geopotential heights from RS92s are also much more precise, ±100~m near 10~hPa compared to only ±1000~m for RS80s. A major advantage of the RS92 is the on-board GPS receiver. It gives more precise altitude information (±10~m), than previously available in the stratosphere. Geopotential heights from RS92s are in very good agreement with the on-board GPS altitudes, typically within ± 100 near 10~hPa (and better below), with some changes between production charges. Our results indicate that long-term records of stratospheric temperature should be corrected for the transition from Vaisala RS80 to the newer and better RS92 radiosonde system. In our presentation we show the main differences and give estimates for an appropriate correction. Reference Steinbrecht, W. et al., 2008, Pressure and Temperature Differences between Vaisala RS80 and RS92 Radiosonde-Systems, J. Atmos. Ocean. Tech., 25, 909--927, doi: 10.1175/2007JTECHA999.1 abstract&doi=10.1175%2F2007JTECHA999.1 class="ab'>

  19. Spectroscopic analyses of the parent stars of extrasolar planetary system candidates

    Microsoft Academic Search

    Guillermo Gonzalez

    1998-01-01

    The stars rho () 1 Cnc, rho CrB, 16 Cyg B, 51 Peg, 47 UMa, 70 Vir, and HD 114762 have recently been proposed to harbor planetary mass companions based on small amplitude radial velocity variations. From spectroscopic analyses we derive the following values of [Fe\\/H] for these stars: 0.29, -0.29, 0.06, 0.21, 0.01, -0.03, and -0.60 (all with an

  20. Ares V and RS-68B

    NASA Technical Reports Server (NTRS)

    Creech, Steve; Taylor, Jim; Bellamy, Scott; Kuck, Fritz

    2008-01-01

    Ares V is the heavy lift vehicle NASA is designing for lunar and other space missions. It has significantly more lift capability than the Saturn V vehicle used for the Apollo missions to the moon. Ares V is powered by two recoverable 5.5 segment solid rocket boosters and six RS-68B engines on the core stage. The upper stage, designated as the Earth Departure Stage, is powered by a single J-2X engine. This paper provides an overview of the Ares V vehicle and the RS-68B engine, an upgrade to the Pratt & Whitney Rocketdyne RS-68 engine developed for the Delta IV vehicle.

  1. Search for RS-gravitons at CDF

    SciTech Connect

    Strologas, John; /New Mexico U.

    2011-09-01

    We present a search for Randall-Sundrum (RS) gravitons decaying to diphotons or dielectrons or dimuons, performed with the CDF II detector and using up to 5.7 fb{sup -1} of integrated luminosity. The respective mass spectra are consistent with the ones expected by the standard model. For the RS-model parameter k/{bar M}{sub Pl} = 0.1, RS-gravitons with mass less than 1111 GeV/c{sup 2} are excluded at 95% CL.

  2. Variability in the super-Earth 55 Cnc e

    E-print Network

    Demory, Brice-Olivier; Madhusudhan, Nikku; Queloz, Didier

    2015-01-01

    Considerable progress has been made in recent years in observations of atmospheric signatures of giant exoplanets, but processes in rocky exoplanets remain largely unknown due to major challenges in observing small planets. Numerous efforts to observe spectra of super-Earths, exoplanets with masses of 1-10 Earth masses, have thus far revealed only featureless spectra. In this paper we report a 4-$\\sigma$ detection of variability in the dayside thermal emission from the transiting super-Earth 55 Cancri e. Dedicated space-based monitoring of the planet in the mid-infrared over eight eclipses revealed the thermal emission from its dayside atmosphere varying by a factor 3.7 between 2012 and 2013. The amplitude and trend of the variability are not explained by potential influence of star spots or by local thermal or compositional changes in the atmosphere over the short span of the observations. The possibility of large scale surface activity due to strong tidal interactions possibly similar to Io, or the presence...

  3. It's a dramatic scene--the kind played out with precision and compassion at the new University of Utah Clinical Neurosciences Center (CNC). Unparalleled advances in our understanding of the

    E-print Network

    Capecchi, Mario R.

    of Utah Clinical Neurosciences Center (CNC). Unparalleled advances in our understanding of the brain in the Intermountain West is the University's CNC, which for the first time unites the School of Medicine's departments and Huntsman Cancer Hospital. Also affiliated with the CNC are the largest pediatric neurosurgery service

  4. Wisconsin Longitudinal Study SNPs Gene rs # disease/behavior notes

    E-print Network

    Wisconsin at Madison, University of

    2 rs174575 IQ intronic, 0.39 heterozygosity FADS2 rs1535 IQ intronic, 0.41 heterozygosity HFE rs3990403 Fertility 3' UTR, 0.47 heterozygosity CH25H rs3802657 Alzheimer's 3' UTR, 0.41 heterozygosity FADS

  5. An Expanding Shell and Synchrotron Jet in RS Ophiuchi

    E-print Network

    Michael P. Rupen; Amy J. Mioduszewski; Jennifer L. Sokoloski

    2007-11-07

    We report high-resolution radio imaging of the recurrent nova RS Ophiuchi (RS Oph) during the first month of the 2006 outburst, using the Very Long Baseline Array (VLBA). Observations made on days 20.8 and 26.8 of the outburst show a synchrotron-emitting partial shell that is much brighter to the east than to the west. Assuming the broad component of the infrared lines corresponds to the outermost part of the shell seen by the VLBA, the distance to the source is $2.45\\pm0.4 kpc$. The circular shape and spectral indices of the shell emission challenge simple models for the radio structure immediately after the outburst. The second epoch also shows an additional, resolved, synchrotron-emitting component well to the east of the shell. Its inferred velocity is comparable to the escape speed from the surface of a high-mass white dwarf. This component was not seen in the first epoch. Its appearance may be related to the outflow reaching the edge of the nebula created by the red giant wind, which had been re-filling the void left by the last outburst in 1985. This eastern component is likely related to the jets previously seen in this and other symbiotic stars, and represents the earliest clear detection of such a jet, as well as the best case yet for synchrotron emission from a white dwarf jet.

  6. H I OBSERVATIONS OF THE ASYMPTOTIC GIANT BRANCH STAR X HERCULIS: DISCOVERY OF AN EXTENDED CIRCUMSTELLAR WAKE SUPERPOSED ON A COMPACT HIGH-VELOCITY CLOUD

    SciTech Connect

    Matthews, L. D.; Johnson, M. C. [MIT Haystack Observatory, Off Route 40, Westford, MA 01886 (United States); Libert, Y. [IRAM, 300 Rue de la Piscine, Domaine Universitaire, 38406 Saint Martin d'Heres (France); Gerard, E. [GEPI, UMR 8111, Observatoire de Paris, 5 Place J Janssen, F-92195 Meudon Cedex (France); Le Bertre, T. [LERMA, UMR 8112, Observatoire de Paris, 61 av. de l'Observatoire, F-75014 Paris (France); Dame, T. M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS-42, Cambridge, MA 02138 (United States)

    2011-02-15

    We report H I 21 cm line observations of the asymptotic giant branch (AGB) star X Her obtained with the Robert C. Byrd Green Bank Telescope (GBT) and the Very Large Array. We have unambiguously detected H I emission associated with the circumstellar envelope of the star, with a mass totaling M{sub HI} {approx} 2.1 x 10{sup -3} M{sub sun}. The H I distribution exhibits a head-tail morphology, similar to those previously observed around the AGB stars Mira and RS Cnc. The tail is elongated along the direction of the star's space motion, with a total extent of {approx}> 6.'0 (0.24 pc) in the plane of the sky. We also detect a systematic radial velocity gradient of {approx}6.5 km s{sup -1} across the H I envelope. These results are consistent with the H I emission tracing a turbulent wake that arises from the motion of a mass-losing star through the interstellar medium (ISM). GBT mapping of a 2{sup 0} x 2{sup 0} region around X Her reveals that the star lies (in projection) near the periphery of a much larger H I cloud that also exhibits signatures of interaction with the ISM. The properties of the cloud are consistent with those of compact high-velocity clouds. Using {sup 12}CO J = 1-0 observations, we have placed an upper limit on its molecular gas content of N{sub H2} < 1.3 x 10{sup 20} cm{sup -2}. Although the distance to the cloud is poorly constrained, the probability of a chance coincidence in position, velocity, and apparent position angle of space motion between X Her and the cloud is extremely small, suggesting a possible physical association. However, the large H I mass of the cloud ({approx}>2.4 M{sub sun}) and the blueshift of its mean velocity relative to X Her are inconsistent with an origin tied directly to ejection from the star.

  7. AT Cnc: A SECOND DWARF NOVA WITH A CLASSICAL NOVA SHELL

    SciTech Connect

    Shara, Michael M.; Mizusawa, Trisha; Zurek, David [Department of Astrophysics, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024-5192 (United States); Wehinger, Peter [Steward Observatory, the University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Martin, Christopher D.; Neill, James D.; Forster, Karl [Department of Physics, Math and Astronomy, California Institute of Technology, 1200 East California Boulevard, Mail Code 405-47, Pasadena, CA 91125 (United States); Seibert, Mark [Observatories of the Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States)

    2012-10-20

    We are systematically surveying all known and suspected Z Cam-type dwarf novae for classical nova shells. This survey is motivated by the discovery of the largest known classical nova shell, which surrounds the archetypal dwarf nova Z Camelopardalis. The Z Cam shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts, in accord with the hibernation scenario of cataclysmic binaries. Here we report the detection of a fragmented 'shell', 3 arcmin in diameter, surrounding the dwarf nova AT Cancri. This second discovery demonstrates that nova shells surrounding Z Cam-type dwarf novae cannot be very rare. The shell geometry is suggestive of bipolar, conical ejection seen nearly pole-on. A spectrum of the brightest AT Cnc shell knot is similar to that of the ejecta of the classical nova GK Per, and of Z Cam, dominated by [N II] emission. Galaxy Evolution Explorer FUV imagery reveals a similar-sized, FUV-emitting shell. We determine a distance of 460 pc to AT Cnc, and an upper limit to its ejecta mass of {approx}5 Multiplication-Sign 10{sup -5} M {sub Sun }, typical of classical novae.

  8. Evolutionary insights about bacterial GlxRS from whole genome analyses: is GluRS2 a chimera?

    PubMed Central

    2014-01-01

    Background Evolutionary histories of glutamyl-tRNA synthetase (GluRS) and glutaminyl-tRNA synthetase (GlnRS) in bacteria are convoluted. After the divergence of eubacteria and eukarya, bacterial GluRS glutamylated both tRNAGln and tRNAGlu until GlnRS appeared by horizontal gene transfer (HGT) from eukaryotes or a duplicate copy of GluRS (GluRS2) that only glutamylates tRNAGln appeared. The current understanding is based on limited sequence data and not always compatible with available experimental results. In particular, the origin of GluRS2 is poorly understood. Results A large database of bacterial GluRS, GlnRS, tRNAGln and the trimeric aminoacyl-tRNA-dependent amidotransferase (gatCAB), constructed from whole genomes by functionally annotating and classifying these enzymes according to their mutual presence and absence in the genome, was analyzed. Phylogenetic analyses showed that the catalytic and the anticodon-binding domains of functional GluRS2 (as in Helicobacter pylori) were independently acquired from evolutionarily distant hosts by HGT. Non-functional GluRS2 (as in Thermotoga maritima), on the other hand, was found to contain an anticodon-binding domain appended to a gene-duplicated catalytic domain. Several genomes were found to possess both GluRS2 and GlnRS, even though they share the common function of aminoacylating tRNAGln. GlnRS was widely distributed among bacterial phyla and although phylogenetic analyses confirmed the origin of most bacterial GlnRS to be through a single HGT from eukarya, many GlnRS sequences also appeared with evolutionarily distant phyla in phylogenetic tree. A GlnRS pseudogene could be identified in Sorangium cellulosum. Conclusions Our analysis broadens the current understanding of bacterial GlxRS evolution and highlights the idiosyncratic evolution of GluRS2. Specifically we show that: i) GluRS2 is a chimera of mismatching catalytic and anticodon-binding domains, ii) the appearance of GlnRS and GluRS2 in a single bacterial genome indicating that the evolutionary histories of the two enzymes are distinct, iii) GlnRS is more widespread in bacteria than is believed, iv) bacterial GlnRS appeared both by HGT from eukarya and intra-bacterial HGT, v) presence of GlnRS pseudogene shows that many bacteria could not retain the newly acquired eukaryal GlnRS. The functional annotation of GluRS, without recourse to experiments, performed in this work, demonstrates the inherent and unique advantages of using whole genome over isolated sequence databases. PMID:24521160

  9. Taking the lab into the classroom: Using mobile technology to monitor and receive data from CNC machines

    Microsoft Academic Search

    Victor M. Monroy; Juan de Dios Calderón

    2005-01-01

    Technology education requires students to understand how theory relates to practice. This relation is established during laboratory sessions carried out during the course. Unfortunately, this laboratory work is often conducted in after-class sessions, limiting the opportunity for the professor to show in theory and practice in parallel, losing the opportunity to maximize learning. The present work shows how a CNC

  10. Advanced CNC and CAM Series. Educational Resources for the Machine Tool Industry. Course Syllabi, Instructor's Handbook [and] Student Laboratory Manual.

    ERIC Educational Resources Information Center

    Texas State Technical Coll. System, Waco.

    This package consists of course syllabi, an instructor's handbook, and student laboratory manual for a 1-year vocational training program to prepare students for entry-level positions as advanced computer numerical control (CNC) and computer-assisted manufacturing (CAM) technicians.. The program was developed through a modification of the DACUM…

  11. Fuzzy Petri nets with neural networks to model products quality from a CNC-milling machining centre

    Microsoft Academic Search

    Moheb M. Hanna; Arthur Buck; Roger Smith

    1996-01-01

    This paper presents a Petri net approach for the modeling of a CNC-milling machining centre. Next, by utilizing fuzzy logic with Petri nets (fuzzy Petri nets), a technique based on 9 fuzzy rules is developed. This paper demonstrates how fuzzy input variables, fuzzy marking, fuzzy firing sequences, and a global output variable should be defined for use with fuzzy Petri

  12. Taguchi-fuzzy multi output optimization (MOO) in high speed CNC turning of AISI P-20 tool steel

    Microsoft Academic Search

    Anil Gupta; Hari Singh; Aman Aggarwal

    2011-01-01

    This paper presents the application of Taguchi method with logical fuzzy reasoning for multiple output optimization of high speed CNC turning of AISI P-20 tool steel using TiN coated tungsten carbide coatings. The machining parameters (cutting speed, feed rate, depth of cut, nose radius and cutting environment) are optimized with considerations of the multiple performance measures (surface roughness, tool life,

  13. FPGA-Based Vibration Analyzer for Continuous CNC Machinery Monitoring With Fused FFT-DWT Signal Processing

    Microsoft Academic Search

    Jose de Jesus Rangel-Magdaleno; René de Jesús Romero-Troncoso; Roque Alfredo Osornio-Rios; Eduardo Cabal-Yepez; Aurelio Dominguez-Gonzalez

    2010-01-01

    The industry of machine tools keeps a constant progress that responds to the most demanding market requirements, such as production-time decreasing and zero-defect manufacturing. As part of this progress, sensors and monitoring instruments have been integrated on machine tools, improving computer numerical control (CNC) and monitoring during the manufacturing process. The vibrations are one of the most significant variables to

  14. SEAC4RS Data and Information Page

    Atmospheric Science Data Center

    2015-07-01

    ... operation was based in Houston, Texas.  The primary SEAC4RS science objectives are: to determine how pollutant emissions are redistributed ... to in-situ cloud characterizations.  To accomplish the science objectives, the flight plans were designed to investigate the influence ...

  15. Rowan: RS 2012 GravitationalWave Astronomy

    E-print Network

    Hinton, Jim

    Xiv:1003.2480 #12;Rowan: RS 2012 Types of GW Burst Searches ·Allsky, alltimes search ­Analyze all available data for GW bursts arriving from any direction (offline search ­ can be done with months/year latency events (GRBs, magnetar flares, pulsar timing glitches...) ­ Candidate transient signals (highenergy

  16. Mr. R.'s World of Math

    NSDL National Science Digital Library

    Mr. R.'s World of Math is a teacher-created collection of math videos, poems, stories, songs, and challenges to help students master basic math functions. In addition to videos there are printable student handouts for the math challenges and several powerpoint demonstrations.

  17. 108 New Variable Stars in the NSVS Database

    Microsoft Academic Search

    Maxim Usatov; Artem Nosulchik

    2008-01-01

    In this paper we present 105 SR+L, 1 Orion T Tau and 2 RS CVn type variable stars found in the Northern Sky Variability Survey (NSVS) database. This work is designated to complement and finalize our previous publication of the Extended Catalog of Red AGB Variable Stars found in the NSVS database as is primarily designated to find SR+L stars.

  18. Study on grinding of free-form optics surface in three-axis CNC machine

    NASA Astrophysics Data System (ADS)

    Yang, Haicheng; Zhang, Yun-long; Zhang, Feng; Wang, Zhibin; Bao, Long-xiang; Su, Ying; Guo, Rui; Liu, Xuan-min

    2014-08-01

    Due to the glass is a type of brittle material, so the high-precision free-form optics of glass material is usually machined by the technical of grinding. In this paper, for the characteristics of the diamond grinding wheel, analyzing the grinding path of free-form optics and mathematical model of the path is established based on the three-axis CNC grinding device. Moreover, the cause of the interference in the process of grinding is analyzed and the methods of avoiding. Finally, based on the above analysis results, through the experiment, the free-form optics surface accuracy was reached to 3.6um, realize the machining of the free-form optics.

  19. Optimization of Operation Sequence in CNC Machine Tools Using Genetic Algorithm

    NASA Astrophysics Data System (ADS)

    Abu Qudeiri, Jaber; Yamamoto, Hidehiko; Ramli, Rizauddin

    The productivity of machine tools is significantly improved by using microcomputer based CAD/CAM systems for NC program generation. Currently, many commercial CAD/CAM packages that provide automatic NC programming have been developed and applied to various cutting processes. Many cutting processes machined by CNC machine tools. In this paper, we attempt to find an efficient solution approach to determine the best sequence of operations for a set of operations that located in asymmetrical locations and different levels. In order to find the best sequence of operations that achieves the shortest cutting tool travel path (CTTP), genetic algorithm is introduced. After the sequence is optimized, the G-codes that use to code for the travel time is created. CTTP can be formulated as a special case of the traveling salesman problem (TSP). The incorporation of genetic algorithm and TSP can be included in the commercial CAD/CAM packages to optimize the CTTP during automatic generation of NC programs.

  20. Development of Sequential Optimization Method for CNC Turning Based on In-Process Tool Wear Monitoring

    NASA Astrophysics Data System (ADS)

    Moriwaki, Toshimichi; Tangjitsitcharoen, Somkiat; Shibasaka, Toshiroh

    A system and procedures are developed to optimize the cutting speed for CNC turning. The current amount of tool wear is estimated based on the in-process cutting force measurement by applying the method developed and reported previously. Once the tool wear is estimated for the different cutting speeds, the coefficients of the Taylor’s tool life equation are determined or successively modified based on the estimated tool wear data. The optimum cutting speed is obtained by referring to the criteria of either the minimum production cost or the maximum production rate. The system developed is applied to actual turning of carbon steel with coated carbide tools, and it has been proved that the system runs satisfactory. The method developed here can be readily applied to unknown combinations of the work material and the tool, as it searches the optimum cutting conditions automatically while the process is going on.

  1. Association between ANKK1 (rs1800497) and LTA (rs909253) Genetic Variants and Risk of Schizophrenia

    PubMed Central

    Arab, Arwa H.; Elhawary, Nasser A.

    2015-01-01

    Limited research has assessed associations between schizophrenia and genetic variants of the ankyrin repeat and kinase domain containing 1 (ANKK1) and lymphotoxin-alpha (LTA) genes among individuals of Middle Eastern ancestry. Here we present the first association study investigating the ANKK1 rs1800497 (T>C) and LTA rs909253 (A>G) single-nucleotide polymorphisms in an Egyptian population. Among 120 patients with DSM-IV and PANSS (Positive and Negative Syndrome Scale) assessments of schizophrenia and 100 healthy controls, we determined the genotypes for the polymorphisms using endonuclease digestion of amplified genomic DNA. Results confirmed previous findings from different ethnic populations, in that the rs1800497 and rs909253 polymorphisms were both associated with risk of schizophrenia. Differences between the genotypes of cases and controls were strongly significant (P = 0.0005 for rs1800497 and P = 0.001 for rs909253). The relative risk to schizophrenia was 1.2 (P = 0.01) for the C allele and 0.8 (P = 0.04) for the G allele. The CC, GG, and combined CC/AA genotypes were all more frequent in cases than in controls. These results support an association between ANKK1 and LTA genetic markers and vulnerability to schizophrenia and show the potential influence of just one copy of the mutant C or G allele in the Egyptian population.

  2. Concurrent Collections (CnC): A new approach to parallel programming

    SciTech Connect

    None

    2010-05-07

    A common approach in designing parallel languages is to provide some high level handles to manipulate the use of the parallel platform. This exposes some aspects of the target platform, for example, shared vs. distributed memory. It may expose some but not all types of parallelism, for example, data parallelism but not task parallelism. This approach must find a balance between the desire to provide a simple view for the domain expert and provide sufficient power for tuning. This is hard for any given architecture and harder if the language is to apply to a range of architectures. Either simplicity or power is lost. Instead of viewing the language design problem as one of providing the programmer with high level handles, we view the problem as one of designing an interface. On one side of this interface is the programmer (domain expert) who knows the application but needs no knowledge of any aspects of the platform. On the other side of the interface is the performance expert (programmer or program) who demands maximal flexibility for optimizing the mapping to a wide range of target platforms (parallel / serial, shared / distributed, homogeneous / heterogeneous, etc.) but needs no knowledge of the domain. Concurrent Collections (CnC) is based on this separation of concerns. The talk will present CnC and its benefits. About the speaker Kathleen Knobe has focused throughout her career on parallelism especially compiler technology, runtime system design and language design. She worked at Compass (aka Massachusetts Computer Associates) from 1980 to 1991 designing compilers for a wide range of parallel platforms for Thinking Machines, MasPar, Alliant, Numerix, and several government projects. In 1991 she decided to finish her education. After graduating from MIT in 1997, she joined Digital Equipment’s Cambridge Research Lab (CRL). She stayed through the DEC/Compaq/HP mergers and when CRL was acquired and absorbed by Intel. She currently works in the Software and Services Group / Technology Pathfinding and Innovation.

  3. Concurrent Collections (CnC): A new approach to parallel programming

    ScienceCinema

    None

    2011-10-06

    A common approach in designing parallel languages is to provide some high level handles to manipulate the use of the parallel platform. This exposes some aspects of the target platform, for example, shared vs. distributed memory. It may expose some but not all types of parallelism, for example, data parallelism but not task parallelism. This approach must find a balance between the desire to provide a simple view for the domain expert and provide sufficient power for tuning. This is hard for any given architecture and harder if the language is to apply to a range of architectures. Either simplicity or power is lost. Instead of viewing the language design problem as one of providing the programmer with high level handles, we view the problem as one of designing an interface. On one side of this interface is the programmer (domain expert) who knows the application but needs no knowledge of any aspects of the platform. On the other side of the interface is the performance expert (programmer or program) who demands maximal flexibility for optimizing the mapping to a wide range of target platforms (parallel / serial, shared / distributed, homogeneous / heterogeneous, etc.) but needs no knowledge of the domain. Concurrent Collections (CnC) is based on this separation of concerns. The talk will present CnC and its benefits. About the speaker Kathleen Knobe has focused throughout her career on parallelism especially compiler technology, runtime system design and language design. She worked at Compass (aka Massachusetts Computer Associates) from 1980 to 1991 designing compilers for a wide range of parallel platforms for Thinking Machines, MasPar, Alliant, Numerix, and several government projects. In 1991 she decided to finish her education. After graduating from MIT in 1997, she joined Digital Equipment?s Cambridge Research Lab (CRL). She stayed through the DEC/Compaq/HP mergers and when CRL was acquired and absorbed by Intel. She currently works in the Software and Services Group / Technology Pathfinding and Innovation.

  4. The resonance line of B II in IUE spectra of chemically peculiar stars

    NASA Technical Reports Server (NTRS)

    Leckrone, D. S.

    1981-01-01

    A description is presented of high-dispersion spectroscopic observations of eight chemically peculiar stars including Kappa Cnc and Mu Lep, and of one normal comparison star, Nu Cap, in the vicinity of 1362 A. The reported data were obtained with the International Ultraviolet Explorer during the first 15 months of its operation. The initial reduction of the data, which were originally described in a qualitative summary by Leckrone (1980), was affected by a serious error in the calibration of the instrument's intensity transfer function. This error has been corrected in the currently presented data. The results of spectrum syntheses of the 1362 A feature are also described for several of the stars.

  5. PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study.

    PubMed

    Garatachea, Nuria; Fuku, Noriyuki; He, Zi-Hong; Tian, Ye; Arai, Yasumichi; Abe, Yukiko; Murakami, Haruka; Miyachi, Motohiko; Yvert, Thomas; Venturini, Letizia; Santiago, Catalina; Santos-Lozano, Alejandro; Rodríguez, Gabriel; Ricevuti, Giovanni; Pareja-Galeano, Helios; Sanchis-Gomar, Fabian; Emanuele, Enzo; Hirose, Nobuyoshi; Lucia, Alejandro

    2014-10-01

    Focal adhesion is critical for cell survival. The focal adhesion kinase (FAK, or PTK2) is an important component of the human interactome and thus is a potential longevity-related protein. Here we studied the association between two PTK2 gene single-nucleotide polymorphisms (SNPs) (rs7843014, rs7460) and exceptional longevity (EL). In addition to gaining insight into their functionality by determining luciferase gene reporter activity, we studied the genotype/allele frequency of these two SNPs among three different cohorts: (1) Spanish centenarians (n=175, 100-111 years, 144 women) and healthy controls (n=355, 20-50 years, 284 women); (2) Italian centenarians (n=79, 100-104 years, 40 women) and controls (n=316, 29-50 years, 156 women); and (3) Japanese centenarians (n=742, 100-116 years, 623 women) and healthy controls (n=499, 23-59 years, 356 women). Both SNPs had functional significance, with the A allele up-regulating luciferase activity compared to the other allele (rs7460 T allele and rs7843014 C allele, respectively). The A allele of both SNPs was negatively associated with EL in the Spanish cohort (rs7460, odds ratio [OR] adjusted by sex=0.40, 95% confidence intervals [CI] 0.3, 0.6, p<0.001); rs7843014, OR=0.37, 95% CI 0.3, 0.5, p<0.001). The OR of being a centenarian if having the rs7460-TT genotype was 6.68 (95% CI 4.1, 10.8, p<0.001). The rs7843014 CC genotype was also positively associated with EL (OR=7.58, 95% CI 4.6, 12.3, p<0.001]. No association was, however, found for the Italian or Japanese cohorts. Thus, two genotypes of the FAK gene, rs7460 TT and rs7843014 CC, are possibly associated with lower gene expression and might favor the likelihood of reaching EL in the Spanish population. Further research is needed to unveil the mechanisms by which FAK expression could perhaps influence the rate of aging. PMID:24930376

  6. SFH/NC-BFSK Erasure insertion RS-BCH

    E-print Network

    Song, Hong-Yeop

    /NC-BFSK . erasure insertion BCH . BCH , RS BCH . SNR(Signal to noise ratio) SJR 2014 SFH/NC-BFSK Erasure insertion RS-BCH , , , , *, *, ** , *, ** {carisis, yangpw-Jamming Scheme Using RS-BCH Concatenation Code and Erasure Insertion in the SFH/BFSK System under Partial Band

  7. Oldenlandia affinis (R&S) DC

    Microsoft Academic Search

    Lorents Gran; Finn Sandberg; Knut Sletten

    2000-01-01

    A review of the geographical distribution, clinical use, biological activity and phytochemistry of Oldenlandia affinis (R&S) DC. is presented. During an inventory of medicinal plants in northern Congo\\/Brazzaville and south-western Central African Republic in 1962, 196 different species were registered, one of which was O. affinis used for the facilitation of childbirth. A medical team working in Luluabourg (Kananga) in

  8. Observations and a new interpretation for the delta Scuti variable star VZ Cancri

    SciTech Connect

    Cox, A.N.; McNamara, B.J.; Ryan, W.

    1984-09-01

    Extensive numbers of new photoelectric data have been collected and analyzed to investigate the modal behavior of VZ Cnc. Its previously observed periods yield a period ratio of 0.80 implying pulsation in the first and second radial overtones. Of the seventeen delta Scuti stars listed by Fitch and Sziedl which have well-determined periods, it is the only star which apparently does not pulsate in the fundamental mode. This peculiarity is investigated from the standpoint of a change with time of the dominant pulsation mode and atmospheric helium settling. The former suggestion is found to be untenable. The latter is found to increase the theoretical ratio of the first overtone/fundamental periods to that observed. It is thus suggested that VZ Cnc pulsates in these lowest order modes and that its atmosphere has been largely depleted of helium. However, if VZ Cnc has a temperatur as large as 7500 K, its position in the instability strip places this star near the transition line between the first and second overtone pulsation modes, beyond the fundamental mode blue edge. In this case the fundamental mode cannot exist, and the 1H and 2H modes are properly identified.

  9. A&A 503, 165176 (2009) DOI: 10.1051/0004-6361/200911918

    E-print Network

    2009-01-01

    of the close binary stars AH Cnc, EV Cnc, ES Cnc, the Scuti type systems EX Cnc and EW Cnc, and some long Cnc were obtained during three observing seasons. Likewise we gathered three light curves of EV Cnc, an EB-type binary, and two light curves of ES Cnc, a blue straggler binary. Parts of the light change

  10. TERT polymorphisms rs2853669 and rs7726159 influence on prostate cancer risk in Russian population.

    PubMed

    Shadrina, Alexandra S; Boyarskikh, Uljana A; Oskina, Natalja A; Sinkina, Tatiana V; Lazarev, Alexandr F; Petrova, Valentina D; Filipenko, Maxim L

    2015-02-01

    Telomere length and telomerase activity have been hypothesized to play a role in cancer development. The aim of our study was to investigate the association of allelic variants of three functional polymorphisms rs2853669, rs2736100, and rs7726159 in the telomerase reverse transcriptase (TERT) gene with the risk of the breast cancer and prostate cancer in Russian population. Six hundred sixty women with breast cancer, 372 men with prostate cancer, and corresponding control groups of 523 women and 363 men were included in the present case-control study. We observed an association of allele rs2853669 C with increased risk of prostate cancer (co-dominant model TC vs. TT OR?=?1.65, P?=?0.002; additive model OR?=?1.42, P?=?0.005; dominant model: OR?=?1.64, P?=?0.001) and allele rs7726159 A with reduced risk of this malignancy (?o-dominant model: AA vs. CC OR?=?0.42, P?=?0.002; additive model: OR?=?0.69, P?=?0.002; dominant model: OR?=?0.67, P?=?0.01; recessive model: OR?=?0.48, P?=?0.005). None of the studied polymorphisms showed an association with the risk of breast cancer. Our results provide evidence that the TERT gene variability modulate prostate cancer predisposition in ethnical Russians. PMID:25296732

  11. Research of production times and cutting of the spur gears by end mill in CNC milling machine

    Microsoft Academic Search

    Cihan Özel

    2011-01-01

    In the current study, differently from the conventional manufacturing methods, cutting of spur gear by the end mill in the\\u000a computer numerically controlled (CNC) vertical milling machine was purposed. For this aim, two different approaches, radial\\u000a and axial cutting methods, were introduced. However, the cutting process is performed by use of only the radial cutting method.\\u000a Parametric equations of tool

  12. Closed-loop CAPP\\/CAM\\/CNC process chain based on STEPand STEP-NC inspection tasks

    Microsoft Academic Search

    C. Brecher; M. Vitr; J. Wolf

    2006-01-01

    The object-oriented STEP-NC programming interface supports a bi-directional data exchange between computer-aided manufacturing (CAM) systems and computerized numerical controllers (CNCs), and by that helps to integrate the CNC into the CAx (Computer Aided technologies in general) world. In this context the current paper introduces the integration of measuring technology into the STEP-NC-based process chain, to be able to preserve the

  13. Optimization in CNC end milling of UNS C34000 medimum leaded brass with multiple surface roughnesses characteristics

    Microsoft Academic Search

    Bharat Chandra Routara; Saumya Darsan Mohanty; Saurav Datta; Asish Bandyopadhyay; Siba Sankar Mahapatra

    2010-01-01

    The present study highlights a multi-objective optimization problem by applying utility concept coupled with Taguchi method\\u000a through a case study in CNC end milling of UNS C34000 medium leaded brass. The study aimed at evaluating the best process\\u000a environment which could simultaneously satisfy multiple requirements of surface quality. In view of the fact, the traditional\\u000a Taguchi method cannot solve a

  14. Optical and X-ray studies of chromospherically active stars: FR Cancri, HD 95559 and LO Pegasi

    NASA Technical Reports Server (NTRS)

    Pandey, J. C.; Singh, K. P.; Drake, S. A.; Sagar, R.

    2005-01-01

    We present a multiwavelength study of three chromospherically active stars, namely FR Cnc (= BD +16 degrees 1753), HD 95559 and LO Peg (=BD +22 degrees 4409), including newly obtained optical photometry, (for FR Cnc) low-resolution optical spectroscopy, as well as archival IR and X-ray observations. The BVR photometry carried out during the years 2001 - 2004 has found significant photometric variability to be present in all three stars. For FR Cnc, a photometric period 0.826685 +/- 0.000034 d has been established. The strong variation in the phase and amplitude of the FR Cnc light curves when folded on this period implies the presence of evolving and migrating spots or spot groups on its surface. Two independent spots with migration periods of 0.97 and 0.93 years respectively are inferred. The photometry of HD 95559 suggests the formation of a spot (group) during the interval of our observations. We infer the existence of two independent spots or groups in the photosphere of LO Peg, one of which has a migration period of 1.12 years. The optical spectroscopy of FR Cnc carried out during 2002-2003, reveals the presence of strong and variable Ca I1 H and K, H(sub beta) and H(sub alpha) emission features indicative of high level of chromospheric activity. The value of 5.3 for the ratio of the excess emission in H(sub alpha) to H(sub beta), EH(sub alpha)/EH(sub beta), suggests that the chromospheric emission may arise from an extended off-limb region. We have searched for the presence of color excesses in the near-IR JHK bands of these stars using 2MASS data, but none of them appear to have any significant color excess. We have also analyzed archival X-ray observations of HD 95559 and LO Peg carried out by with the ROSAT observatory. The best fit models to their X-ray spectra imply the presence of two coronal plasma components of differing temperatures and with sub-solar metal abundances. The inferred emission measures and temperatures of these systems are similar to those found for other active dwarf stars. The kinematics of FR Cnc suggest that it is a very young (35 - 55 Myrs) main-sequence star and a possible member of the IC 2391 supercluster. LO Peg also has young disk-type kinematics and has been previously suggested to be a member of the 100 Mys old Local Association (Pleiades Moving Group). The kinematics of HD 95559 indicate it is a possible member of the 600 Myrs old Hyades supercluster.

  15. Association of PTPN22 rs2476601 and EGFR rs17337023 Gene polymorphisms and rheumatoid arthritis in Zahedan, Southeast Iran.

    PubMed

    Hashemi, M; Atabaki, M; Daneshvar, H; Zakeri, Z; Eskandari-Nasab, E

    2013-08-01

    In this study we aimed to evaluate the possible association of PTPN22 rs2476601 as well as epidermal growth factor receptor (EGFR) rs17337023 gene polymorphism and rheumatoid arthritis (RA) in a sample of Iranian population. This case-control study was performed on 120 patients with RA and 120 healthy subjects. Genomic DNA was extracted from whole blood and PTPN22 rs2476601 and EGFR rs17337023 polymorphisms were determined using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results showed that PTPN22 rs2476601 CT genotype as well as rs2476601 T allele was a risk factor for susceptibility to RA (OR=5.89 95%CI = 1.78-19.48, P = 0.004 and OR = 4.78, 95%CI = 1.59-14.35, P = 0.003, respectively). We also found that EGFR rs17337023 AT and rs17337023 TT genotypes were risk factor for susceptibility to RA (OR = 9.94 95%CI = 3.65-26.73, P < 0.001 and OR = 3.66, 95%CI = 1.46-9.15, P = 0.005, respectively). In addition the EGFR rs17337023 T allele was a risk for predisposition to RA (OR = 1.56, 95%CI=1.06-2.30, P = 0.030). In conclusion, we found an association between PTPN22 rs2476601 and EGFR rs17337023 polymorphisms and the risk of RA in a sample of Iranian population. PMID:23350658

  16. STEP-compliant NC research: the search for intelligent CAD\\/CAPP\\/CAM\\/CNC integration

    Microsoft Academic Search

    X. W. Xu; H. Wang; J. Mao; S. T. Newman; T. R. Kramer; F. M. Proctor; J. L. Michaloski

    2005-01-01

    Since the first generation of Numerically Controlled (NC) machine tools was developed in the 1950s, there have been many developments which make today's NC machines completely unrecognizable from their early ancestors. Further developments, however, are now being significantly limited by the current programming language (ISO6983 or RS274D) that has been supporting NC manufacture since day one. Today a new standard,

  17. A Super-Earth Transiting a Naked-eye Star

    NASA Astrophysics Data System (ADS)

    Winn, Joshua N.; Matthews, Jaymie M.; Dawson, Rebekah I.; Fabrycky, Daniel; Holman, Matthew J.; Kallinger, Thomas; Kuschnig, Rainer; Sasselov, Dimitar; Dragomir, Diana; Guenther, David B.; Moffat, Anthony F. J.; Rowe, Jason F.; Rucinski, Slavek; Weiss, Werner W.

    2011-08-01

    We have detected transits of the innermost planet "e" orbiting 55 Cnc (V = 6.0), based on two weeks of nearly continuous photometric monitoring with the MOST space telescope. The transits occur with the period (0.74 days) and phase that had been predicted by Dawson & Fabrycky, and with the expected duration and depth for the crossing of a Sun-like star by a hot super-Earth. Assuming the star's mass and radius to be 0.963+0.051 - 0.029 M sun and 0.943 ± 0.010 R sun, the planet's mass, radius, and mean density are 8.63 ± 0.35 M ?, 2.00 ± 0.14 R ?, and 5.9+1.5 - 1.1 g cm-3, respectively. The mean density is comparable to that of Earth, despite the greater mass and consequently greater compression of the interior of 55 Cnc e. This suggests a rock-iron composition supplemented by a significant mass of water, gas, or other light elements. Outside of transits, we detected a sinusoidal signal resembling the expected signal due to the changing illuminated phase of the planet, but with a full range (168 ± 70 ppm) too large to be reflected light or thermal emission. This signal has no straightforward interpretation and should be checked with further observations. The host star of 55 Cnc e is brighter than that of any other known transiting planet, which will facilitate future investigations. Based on data from the MOST satellite, a Canadian Space Agency mission, jointly operated by Dynacon Inc., the University of Toronto Institute for Aerospace Studies, and the University of British Columbia, with the assistance of the University of Vienna.

  18. Development of a high precision tabletop versatile CNC wire-EDM for making intricate micro parts

    NASA Astrophysics Data System (ADS)

    Liao, Yunn-Shiuan; Chen, Shun-Tong; Lin, Chang-Sheng

    2005-02-01

    The micro-electrical discharge machining (micro-EDM) process has been proved to be appropriate for making 3D micro parts that are difficult and even impossible to manufacture by other processes. In this paper a high precision tabletop CNC wire electrical discharge machine (wire EDM) designed specifically for machining complex shape micro parts or structures is developed. In the machine developed, a novel micro-wire-cutting mechanism is designed, an approach to control wire tension by magnetic force is proposed and a servo feed control strategy, in accordance with the measured gap voltage, is designed and implemented. To verify the functions and capabilities of the machine developed, several thick micro outer and internal spur gears and rack are machined. It shows that the taper angle along the wall or cavity of a part that appears when other micro-EDM processes are applied can be avoided. A very good dimensional accuracy of 1 µm and a surface finish of Rmax equal to 0.64 µm are achieved. The satisfactory cutting of a miniature 3D pagoda with a micro-hooked structure also reveals that the machine developed is versatile, and can be used as a new tool for making intricate micro parts.

  19. Improved precision on the radius of the nearby super-Earth 55 Cnc e

    E-print Network

    Gillon, M; Benneke, B; Valencia, D; Deming, D; Seager, S; Lovis, C; Mayor, M; Pepe, F; Queloz, D; Segransan, Damien; Udry, S

    2011-01-01

    We report on new transit photometry for the super-Earth 55 Cnc e obtained with Warm Spitzer/IRAC at 4.5 microns. An individual analysis of these new data leads to a planet radius of 2.21-0.16+0.15 Rearth, in good agreement with the values previously derived from the MOST and Spitzer transit discovery data. A global analysis of both Spitzer transit time-series improves the precision on the radius of the planet at 4.5 microns to 2.20+-0.12 Rearth. We also performed an independent analysis of the MOST data, paying particular attention to the influence of the systematic effects of instrumental origin on the derived parameters and errors by including them in a global model instead of performing a preliminary detrending-filtering processing. We deduce from this reanalysis of MOST data an optical planet radius of 2.04+-0.15 Rearth that is consistent with our Spitzer infrared radius. Assuming the achromaticity of the transit depth, we performed a global analysis combining Spitzer and MOST data that results in a plane...

  20. XMM-Newton observations of the dwarf nova YZ Cnc in quiescence

    E-print Network

    Pasi Hakala; Gavin Ramsay; Peter Wheatley; Emilios Harlaftis; C. Papadimitriou

    2004-03-08

    We present results from the XMM observations of the dwarf nova YZ Cnc in a quiescent state. We have performed a detailed time series analysis of the resulting light curves. Unusually, we do not detect any orbital modulation in the UV, with only marginal evidence for X-ray modulation on this period. Although there are peaks in the X-ray periodograms at periods less than 5000 s, we attribute them to red noise effects and assign significance to them using a novel approach. The variability in the UV and optical bands can also be modelled as a result of aperiodic variability (red noise) in the system. There is evidence that the UV and X-ray fluxes are anti-correlated with a time delay of about 100 s, with the UV lagging behind the X-ray emission. This anti-correlation is intriguing, but is only present on two occasions lasting several 1000 s each. The X-ray spectrum shows similar emission features to other dwarf novae and is well fitted using a multi-temperature emission model. We measure a relatively high X-ray luminosity of ~1.4x10^{32} ergs/s, although this is consistent with a low binary inclination. Finally, we find evidence for a possible -1200km/s blue shift in the fitted Fe K line energies, possibly indicating the presence of an outflow in this low inclination system.

  1. AT Cnc: A Second Dwarf Nova with a Classical Nova Shell

    E-print Network

    Shara, Michael M; Wehinger, Peter; Zurek, David; Martin, Christopher D; Neill, James D; Forster, Karl; Seibert, Mark

    2012-01-01

    We are systematically surveying all known and suspected Z Cam-type dwarf novae for classical nova shells. This survey is motivated by the discovery of the largest known classical nova shell, which surrounds the archetypal dwarf nova Z Camelopardalis. The Z Cam shell demonstrates that at least some dwarf novae must have undergone classical nova eruptions in the past, and that at least some classical novae become dwarf novae long after their nova thermonuclear outbursts, in accord with the hibernation scenario of cataclysmic binaries. Here we report the detection of a fragmented "shell", 3 arcmin in diameter, surrounding the dwarf nova AT Cancri. This second discovery demonstrates that nova shells surrounding Z Cam-type dwarf novae cannot be very rare. The shell geometry is suggestive of bipolar, conical ejection seen nearly pole-on. A spectrum of the brightest AT Cnc shell knot is similar to that of the ejecta of the classical nova GK Per, and of Z Cam, dominated by [NII] emission. Galex FUV imagery reveals a ...

  2. Development of a CNC 5KW CO{sub 2} laser processing equipment

    SciTech Connect

    Zhang Shuren; Lu Boliang; Zhang Hong; Shao Wushan [Changchun Inst. of Optics and Fine Mechanics (China). Dept. of Mechanical Engineering

    1996-12-31

    This paper introduces the fundamental compositions and functions of a newly developed 5KW CO{sub 2} laser processing equipment CGJ-93 controlled by microcomputer in CIOM (Changchun Institute of Optics and Fine Mechanics). The laser processing equipment consists of a 5KW CO{sub 2} laser, multifunction beam guidance system, modular processing machine, water cooling system and CNC system. The equipment has ability to heat-treat not only the internal holes and outer circular surfaces but also space holes and three dimensional curved surfaces. The equipment can heat-treat workpieces up to 3,000 mm length, 1,500mm diameter and 3,000kg weight. The longitudinal table allows moving speed of 0.8--12,000mm per minute with 3,600mm effective moving range and 0.069mm position accuracy. The transverse table allows moving speed of 5--1,2000mm per minute with 1,000mm effective moving range and 0.028 mm position accuracy. The laser head allows longitudinal moving speed of 0.1--1,2000mm per minute, its effective moving range and position accuracy are 540mm and 0.03mm respectively.

  3. Spectroscopic Study of SU UMa-type Dwarf Nova YZ Cnc during its 2002 Superoutburst

    E-print Network

    Ying-he Zhao; Zong-yun Li; Xiao-an Wu; Qiu-he Peng

    2005-07-11

    We report time-resolved spectroscopic observations of the SU Ursae Majoris dwarf nova, YZ Cnc, for 2 nights over 11 hrs during its 2002 January superoutburst. The spectra only show absorption-line profiles in the first day. But the lines display blue and red troughs, with ``W'' profiles in the second day. The radial velocity curve of the absorption troughs and emission peaks of H$\\beta$ has an amplitude of $49\\pm10$ km s$^{-1}$ and a phase offset of $-0.07\\pm0.04$, which are very similar to those measured in quiescence; however, the $\\gamma$ velocity deviates strongly from the systemic velocity measured in quiescence, showing variation of the order of $\\pm$60 km s$^{-1}$. And large shifts of $\\sim$70 km s$^{-1}$ and $\\sim$0.09, for the orbital-averaged velocity and phase respectively, are also found in our observations. All these phenomena can be well explained with a precession of an eccentric disk and we conclude that these phenomena are the characteristic products of an eccentric accretion disk.

  4. Neural nAChRs PET imaging probes.

    PubMed

    Mo, Ye-Xiong; Yin, Ya-Fu; Li, Ya-Ming

    2014-02-01

    There have been a number of attempts to study PET radioligands for imaging nicotinic acetylcholine receptors (nAChRs) in the human brain, and the most successful tracers found are radioligands for imaging ?4?2-nAChRs, which is the main cerebral nAChRs subtype. C-Nicotine and 2-[F]FA have been applied in many studies in humans. However, neither is entirely ideal and efforts have been made to develop radioligands with optimized imaging properties. Only a few reports have been published on radioligands for ?7-nAChRs imaging, another important cerebral nAChRs subtype. This paper will review the development of PET radioligands for imaging cerebral nAChRs. PMID:24240192

  5. Nucleotide Sequence Analysis of pRS2 and pRS3, Two Small Cryptic Plasmids from Oenococcus oeni

    Microsoft Academic Search

    Juan M. Mesas; M. Carmen Rodr??guez; M. Teresa Alegre

    2001-01-01

    Nucleotide sequence analysis of two cryptic plasmids, pRS2 (2544 bp) and pRS3 (3948 bp), from Oenococcus oeni revealed the presence in both of three major open reading frames with significant similarity to other small cryptic plasmids from O. oeni. The results suggest that those plasmids could be separated into two subfamilies, one represented by pLo13 and pRS3, the other represented

  6. The CN/C15N isotopic ratio towards dark clouds

    NASA Astrophysics Data System (ADS)

    Hily-Blant, P.; Pineau des Forêts, G.; Faure, A.; Le Gal, R.; Padovani, M.

    2013-09-01

    Understanding the origin of the composition of solar system cosmomaterials is a central question, not only in the cosmochemistry and astrochemistry fields, and requires various approaches to be combined. Measurements of isotopic ratios in cometary materials provide strong constraints on the content of the protosolar nebula. Their relation with the composition of the parental dark clouds is, however, still very elusive. In this paper, we bring new constraints based on the isotopic composition of nitrogen in dark clouds, with the aim of understanding the chemical processes that are responsible for the observed isotopic ratios. We have observed and detected the fundamental rotational transition of C15N towards two starless dark clouds, L1544 and L1498. We were able to derive the column density ratio of C15N over 13CN towards the same clouds and obtain the CN/C15N isotopic ratios, which were found to be 500 ± 75 for both L1544 and L1498. These values are therefore marginally consistent with the protosolar value of 441. Moreover, this ratio is larger than the isotopic ratio of nitrogen measured in HCN. In addition, we present model calculations of the chemical fractionation of nitrogen in dark clouds, which make it possible to understand how CN can be deprived of 15N and HCN can simultaneously be enriched in heavy nitrogen. The non-fractionation of N2H+, however, remains an open issue, and we propose some chemical way of alleviating the discrepancy between model predictions and the observed ratios. Appendices are available in electronic form at http://www.aanda.orgThe reduced spectra (in FITS format) are available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/557/A65

  7. V474 Car: A Rare Halo RS CVn Binary in Retrograde Galactic Orbit

    E-print Network

    Bubar, Eric J; Jensen, Eric L N; Walter, Frederick M

    2011-01-01

    We report the discovery that the star V474 Car is an extremely active, high velocity halo RS CVn system. The star was originally identified as a possible pre-main sequence star in Carina, given its enhanced stellar activity, rapid rotation (10.3 days), enhanced Li, and absolute magnitude that places it above the main sequence. However, its extreme radial velocity (264 km s$^{-1}$) suggested that this system was unlike any previously known pre-MS system. Our detailed spectroscopic analysis of echelle spectra taken with the CTIO 4-m finds that V474 Car is both a spectroscopic binary with orbital period similar to the photometric rotation period, and metal poor ([Fe/H] $\\simeq -$0.99). The star's Galactic orbit is extremely eccentric (e $\\simeq$ 0.93) with perigalacticon of only $\\sim$0.3 kpc of the Galactic center - and its eccentricity and smallness of its perigalacticon are only surpassed by $\\sim$0.05%, of local F/G-type field stars. The observed characteristics are consistent with V474 Car being a high velo...

  8. RADIAL VELOCITY PLANETS DE-ALIASED: A NEW, SHORT PERIOD FOR SUPER-EARTH 55 Cnc e

    SciTech Connect

    Dawson, Rebekah I.; Fabrycky, Daniel C., E-mail: rdawson@cfa.harvard.ed, E-mail: daniel.fabrycky@gmail.co [Harvard-Smithsonian Center for Astrophysics, 60 Garden St., MS-10, Cambridge, MA 02138 (United States)

    2010-10-10

    Radial velocity measurements of stellar reflex motion have revealed many extrasolar planets, but gaps in the observations produce aliases, spurious frequencies that are frequently confused with the planets' orbital frequencies. In the case of Gl 581 d, the distinction between an alias and the true frequency was the distinction between a frozen, dead planet and a planet possibly hospitable to life. To improve the characterization of planetary systems, we describe how aliases originate and present a new approach for distinguishing between orbital frequencies and their aliases. Our approach harnesses features in the spectral window function to compare the amplitude and phase of predicted aliases with peaks present in the data. We apply it to confirm prior alias distinctions for the planets GJ 876 d and HD 75898 b. We find that the true periods of Gl 581 d and HD 73526 b/c remain ambiguous. We revise the periods of HD 156668 b and 55 Cnc e, which were afflicted by daily aliases. For HD 156668 b, the correct period is 1.2699 days and the minimum mass is (3.1 {+-} 0.4) M{sub +}. For 55 Cnc e, the correct period is 0.7365 days-the shortest of any known planet-and the minimum mass is (8.3 {+-} 0.3) M{sub +}. This revision produces a significantly improved five-planet Keplerian fit for 55 Cnc, and a self-consistent dynamical fit describes the data just as well. As radial velocity techniques push to ever-smaller planets, often found in systems of multiple planets, distinguishing true periods from aliases will become increasingly important.

  9. Gravitational quantization of exoplanet orbits in 55 Cnc, $\\upsilon$ And, Kepler-11, Kepler-20, and Kepler-90

    E-print Network

    Geroyannis, Vassilis S

    2014-01-01

    In the framework of the so-called "global polytropic model", we assume hydrostatic equilibrium for a planetary system, and solve the resulting Lane--Emden differential equation in the complex plane. We thus obtain polytropic spherical shells defined by succesive roots of the real part $\\mathrm{Re}(\\theta)$ of the Lane-Emden function $\\theta$. These shells seem to provide hosting orbits for the planets of the system(s) under consideration. In the present investigation, we study within this framework the exoplanet systems 55 Cnc, $\\upsilon$ And, Kepler-11, Kepler-20, and Kepler-90.

  10. FPGA-Based Fused Smart-Sensor for Tool-Wear Area Quantitative Estimation in CNC Machine Inserts

    PubMed Central

    Trejo-Hernandez, Miguel; Osornio-Rios, Roque Alfredo; de Jesus Romero-Troncoso, Rene; Rodriguez-Donate, Carlos; Dominguez-Gonzalez, Aurelio; Herrera-Ruiz, Gilberto

    2010-01-01

    Manufacturing processes are of great relevance nowadays, when there is a constant claim for better productivity with high quality at low cost. The contribution of this work is the development of a fused smart-sensor, based on FPGA to improve the online quantitative estimation of flank-wear area in CNC machine inserts from the information provided by two primary sensors: the monitoring current output of a servoamplifier, and a 3-axis accelerometer. Results from experimentation show that the fusion of both parameters makes it possible to obtain three times better accuracy when compared with the accuracy obtained from current and vibration signals, individually used. PMID:22319304

  11. Radiation Dry Bias of the Vaisala RS92 Humidity Sensor

    Microsoft Academic Search

    H. Vömel; H. Selkirk; L. Miloshevich; J. Valverde-Canossa; J. Valdés; E. Kyrö; R. Kivi; W. Stolz; G. Peng; J. A. Diaz

    2007-01-01

    The comparison of simultaneous humidity measurements by the Vaisala RS92 radiosonde and by the Cryogenic Frostpoint Hygrometer (CFH) launched at Alajuela, Costa Rica, during July 2005 reveals a large solar radiation dry bias of the Vaisala RS92 humidity sensor and a minor temperature-dependent calibra- tion error. For soundings launched at solar zenith angles between 10° and 30°, the average dry

  12. Responding to the 5Rs: An Alternate Perspective of Slowmation

    ERIC Educational Resources Information Center

    Kidman, Gillian; Keast, Stephen; Cooper, Rebecca

    2012-01-01

    This paper is a response to Hoban and Neilsen's (2010) Five Rs model for understanding how learners engage with slowmation. An alternative model (the Learning MMAEPER Model) that builds on the 5Rs model is explained in terms of its use in secondary science preservice teacher education. To probe into the surface and deep learning that can occur…

  13. Fast decoding of a d(min) = 6 RS code

    NASA Technical Reports Server (NTRS)

    Deng, H.; Costello, D. J., Jr.

    1983-01-01

    A method for high speed decoding a d sub min = 6 Reed-Solomon (RS) code is presented. Properties of the two byte error correcting and three byte error detecting RS code are discussed. Decoding using a quadratic equation is shown. Theorems and concomitant proofs are included to substantiate this decoding method.

  14. [Application possibility of the macrolides for the RS virus infections].

    PubMed

    Yokota, Shin-ichi; Tsutsumi, Hiroyuki; Himi, Tetsuo

    2014-06-01

    Human respiratory syncytial virus (RSV) is a major causative agent of respiratory infections. Common cold syndrome caused by RS virus, which is prevalent in winter, occasionally develops into bronchitis, bronchiolitis and pneumonia. In particular, severe RS virus infections in infants with underlying cardiopulmonary diseases and with low-birth weight baby have been a problem. Furthermore, repetitive RS virus infections occur for the entire lifetime, and the relationship between RS virus infections and exacerbation of COPD and bronchial asthma is also indicated mainly in elderly individuals. Various immunomodulatory effects other than antimicrobial activity of macrolides, including clarithromycin, have been reported, and their clinical usefulness is shown mainly in respiratory diseases. This review describes the findings of action of macrolides on RS virus infections. PMID:25163248

  15. High pressure intensification of cassava resistant starch (RS3) yields.

    PubMed

    Lertwanawatana, Proyphon; Frazier, Richard A; Niranjan, Keshavan

    2015-08-15

    Cassava starch, typically, has resistant starch type 3 (RS3) content of 2.4%. This paper shows that the RS3 yields can be substantially enhanced by debranching cassava starch using pullulanase followed by high pressure or cyclic high-pressure annealing. RS3 yield of 41.3% was obtained when annealing was carried out at 400MPa/60°C for 15 min, whereas it took nearly 8h to obtain the same yield under conventional atmospheric annealing at 60°C. The yield of RS3 could be further significantly increased by annealing under 400 MPa/60°C pressure for 15 min followed by resting at atmospheric pressure for 3h 45 min, and repeating this cycle for up to six times. Microstructural surface analysis of the product under a scanning electron microscope showed an increasingly rigid density of the crystalline structure formed, confirming higher RS3 content. PMID:25794725

  16. GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population.

    PubMed

    Chen, Yong Ping; Song, Wei; Huang, Rui; Chen, Ke; Zhao, Bi; Li, Jianpeng; Yang, Yuan; Shang, Hui-Fang

    2013-06-01

    Numerous single-nucleotide polymorphisms (SNPs) such as GAK rs1564282 and DGKQ rs11248060 have been reported to be associated with the risk of Parkinson's disease (PD) in Caucasian populations. However, this association is yet to be proven in the Chinese population. This study included 376 unrelated Han Chinese PD patients from Southwest China and 277 unrelated Chinese healthy controls from the same region. Two SNPs, namely, rs1564282 and rs11248060, were genotyped using Sequenom's iPLEX assay. The allele frequencies and genotype distributions of the SNPs in the PD patients and controls were compared using Fisher's exact test. Significant differences were found in the genotype distributions and allele frequencies for DGKQ rs11248060 between PD patients and controls (p = 0.0425 and p = 0.0308, respectively). Significant differences were also observed in the allele frequencies for GAK rs1564282 between PD patients and controls. No significant differences were observed in the genotype frequencies, minor allele frequency, and minor allele carrier frequencies between early-onset PD (EOPD) and controls, between late-onset PD (LOPD) and controls, and between EOPD and LOPD after conservative Bonferroni adjustment. GAK rs1564282 and DGKQ rs11248060 increase the risk for PD in Chinese patients. More related studies with a larger number of participants are needed to confirm these findings. PMID:23618683

  17. Association of BID SNPs (rs8190315 and rs2072392) and clinical features of benign prostate hyperplasia in Korean population

    PubMed Central

    Seok, Hosik; Kim, Su Kang; Yoo, Koo Han; Lee, Byung-Cheol; Kim, Young Ock; Chung, Joo-Ho

    2014-01-01

    Exercise has beneficial effect on cancer apoptosis and benign prostatic hyperplasia (BPH). The BH3 interacting domain death agonist (BID) gene expression is associated with apoptosis or cell proliferation. In this study, we investigated the association between BID single nucleotide polymorphisms (SNPs) and the development, prostate volume, and international prostate symptom score (IPSS) of BPH. In 222 BPH males and 214 controls, two SNPs in BID [rs8190315 (Ser56Gly), and rs2072392 (Asp106Asp)] were genotyped and analyzed using multiple logistic regression models. In the result, the genotype and allele frequencies of rs8190315 and rs2072392 were not associated with BPH development or IPSS, however, the allele frequencies [odd ratio (OR)= 1.90, 95% confidence interval (CI)= 1.07–3.41, P= 0.03] and genotype frequencies (in dominant model, OR= 1.94, 95% CI= 1.01–3.74, P= 0.42) of rs8190315, and the genotype frequencies of rs2072392 (in dominant model, OR= 1.94, 95% CI= 1.01–3.74, P= 0.42) were associated with increased prostate volume. We propose that rs8190315 and rs2072392 of BID may contribute to the disease severity of BPH. PMID:25610824

  18. The evolution of the Three Rs.

    PubMed

    Farnaud, Sebastien

    2009-07-01

    Whilst the whole world is celebrating the bicentenary of the birth of Charles Darwin and the 150th anniversary of the publication of his renowned book, The Origin of Species, another anniversary should not be forgotten - the publication of The Principles of Humane Experimental Technique by W.M.S. Russell and R.L. Burch. The concomitance of the anniversaries of the two publications is not a coincidence, since, as reflected by the numerous quotes chosen by Russell from Darwin's masterpiece, numerous analogies can be found between the two works and the new ideas they describe. From a discrete birth, and after decades of struggle, the Three Rs concept can now celebrate its 50th anniversary, the result of its evolution through harsh selection and adaptation. The emergence of new types of techniques, in combination with the descent of modified old ones, testify to the undeniable change in our society toward a more efficient and more ethical science, through the progressive replacement of animal models. Both Darwin and Russell would no doubt have welcomed such progress, not only in terms of science, but also of moral values. One could also expect that, if Russell could have foreseen the incredible technological advances achieved 50 years later, where Replacement becomes a reality, as illustrated by some edifying examples, The Principles of Humane Experimental Technique would have probably been defined as the One R concept. PMID:19678725

  19. On the RS2 realization of unparticles

    NASA Astrophysics Data System (ADS)

    Friedland, Alexander; Giannotti, Maurizio; Graesser, Michael

    2009-07-01

    We consider the Randall-Sundrum 2 setup with the Standard Model fields on the brane and a massive vector field in the warped bulk. We show that in this model the known properties of vector unparticles - the nontrivial phase of the CFT propagator, the necessity and dominance of contact interactions, the unitarity constraint on the conformal dimension of the operator, and the tensor structure dictated by conformal symmetry - follow by simple inspection of the brane-to-brane propagator. The phase has a physical interpretation as controlling the rate of escape of unparticles into the extra dimension. Requiring the correct sign for the imaginary part of the longitudinal polarization of the propagator, we obtain the unitarity condition m52?0, which, unlike in the scalar case, is unchanged from flat space. This condition results in the unitarity bound d?3, or, more generally, d?D-1 for a vector unparticle in D-dimensional space. It is instructive to consider the RS2 propagator in (Euclidean) position space: at large distances it behaves as a pure CFT propagator, while at short distances it turns into the softer 5d flat space propagator. In contrast, in momentum space, at low momenta the CFT piece is subdominant to the “contact” interactions.

  20. Leukocyte Telomere Length-Related rs621559 and rs398652 Genetic Variants Influence Risk of HBV-Related Hepatocellular Carcinoma

    PubMed Central

    Shi, Juan; Lu, Chao; Wei, Jinyu; Li, Lichao; Zhou, Changchun; Yuan, Qipeng; Zhou, Liqing; Yang, Ming

    2014-01-01

    Recent genome-wide association studies (GWAS) have identified eleven leukocyte telomere length (LTL)-related single nucleotide polymorphisms (SNPs). Since LTL has been associated with risk of many malignancies, LTL-related SNPs may contribute to cancer susceptibility. To test this hypothesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we genotyped these eleven LTL-related SNPs in a case-control set including 1186 HBV-related HCC cases, 508 chronic HBV carriers and 1308 healthy controls at the discovery stage. The associations of HCC risk with these SNPs were further confirmed in an independent case-control set. We found that 1p34.2 rs621559 and 14q21 rs398652 were significantly associated with HBV-related HCC risk (both P<0.005 after Bonferroni corrections). There was no significant difference of either rs621559 or rs398652 genotypes between chronic HBV carriers and healthy controls, demonstrating that the association was not due to predisposition to HBV infection. In the pooled analyses (1806 HBV-related HCC cases and 1954 controls), we observed a decreased HCC risk, 0.72-times, associated with the 1p34.2 rs621559 AA genotype compared to the GG genotype (P?=?1.6×10?6). Additionally, there was an increased HCC risk, 1.27-fold, associated with the rs398652 GG genotype (P?=?3.3×10?6). A statistical joint effect between the rs621559 GG and rs398652 GG genotypes may exist in elevating risk of HBV-related HCC. We show, for the first time, that rs398652 and rs621559 might be marker genetic variants for risk of HBV-related HCC in the Chinese population. PMID:25365256

  1. Association Study of Polymorphisms rs4552569 and rs17095830 and the Risk of Ankylosing Spondylitis in a Taiwanese Population

    PubMed Central

    Wei, James Cheng-Chung; Hsu, Yu-Wen; Hung, Kuo-Sheng; Wong, Ruey-Hong; Huang, Chun-Huang; Liu, Yi-Tzu; Guo, Yuh-Cherng; Ikegawa, Shiro; Chang, Wei-Chiao

    2013-01-01

    Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS) showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569) and within ANO6 at 12q12 (rs17095830) contribute to the risk of AS in Han Chinese. In this study, we enrolled 475 AS patients and 475 healthy subjects to assess whether these genetic variations contribute to the susceptibility and the severity of AS in the Taiwanese population. The correlation between genetic polymorphisms, AS activity indexes, (namely, BASDAI, BASFI and BAS-G) and AS complications (uveitis and inflammatory bowel disease) were tested using the markers, rs4552569 and rs17095830. Although no association between rs4552569/rs17095830 genetic polymorphisms and AS susceptibility/severity was found, a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population. PMID:23308121

  2. Niobium in R And (S6, 6e) and HR 1105 (S5, 3). [S star abundance

    NASA Technical Reports Server (NTRS)

    Davis, D. N.

    1985-01-01

    Lines of the first multiplet of niobium are strong in R And and HR 1105. These lines are also present in other S stars: HR 8714, R Cam, V Cnc, R CMi, and T Sgr. They are also visible in the M stars, Beta-Peg and Mu-UMa. An approximation to the abundance ratio, Nb/Fe, has been deduced from pairs of lines having nearly equal intensity. In R And, the ratio is about 200 times the solar value. It is hoped that good plates will soon be obtained for the near infrared region, so that the significant Nb/Rb abundance ratio may be determined.

  3. Enantioselective degradation of (2RS,3RS)-paclobutrazol in peach and mandarin under field conditions.

    PubMed

    Wang, Xiangyun; Qi, Peipei; Yang, Guiling; Wang, Xinquan; Zhang, Hu; Xu, Hao; Wang, Zhiwei; Wang, Qiang

    2014-08-01

    In this study we investigated the enantioselective degradation of (2RS,3RS)-paclobutrazol in peach and mandarin fruits under field conditions after foliar treatment at 500 mg active ingredient/L using a Lux Cellulose-1 chiral column on a reverse-phase liquid chromatography-tandem mass spectrometry system. Degradations of paclobutrazol in both fruits followed first-order kinetics, with half-lives of about 9 days. Initial deposits were 1.63 mg/kg on peach and 1.99 mg/kg on mandarin; terminal concentrations were lower than 0.05 mg/kg, which was acceptable in most cases. As anticipated, paclobutrazol levels in peels of mature mandarin were about 6.3 times higher than in pulp, indicating the potential risk of peel consumption. We also observed that paclobutrazol degradation in mature mandarin was relatively slow, indicating it might not be efficient enough to hold mandarin fruits on trees for lowering paclobutrazol concentrations. Significant enantioselectivity was observed: the (2R,3R)-enantiomer was preferentially degraded in mandarin (whole fruit, peels, and pulp) but enriched in peach. Because of its more rapid degradation in mandarin and the lower levels observed in pulp compared with peels, potential endocrine-related side effects due to the (2R,3R)-enantiomer pose less of a risk in mandarin than in peach. PMID:24890866

  4. Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock

    PubMed Central

    Cardoso, Cristina Padre; de Oliveira, Argenil José de Assis; Botoni, Fernando Antônio; Rezende, Isabela Cristina Porto; Alves-Filho, Jose Carlos; Cunha, Fernando de Queiroz; Estanislau, Juliana de Assis Silva Gomes; Magno, Luiz Alexandre Viana; Rios-Santos, Fabricio

    2015-01-01

    Despite major improvements in its treatment and diagnosis, sepsis is still a leading cause of death and admittance to the intensive care unit (ICU). Failure to identify patients at high risk of developing septic shock contributes to an increase in the sepsis burden and rapid molecular tests are currently the most promising avenue to aid in patient risk determination and therapeutic anticipation. The primary goal of this study was to evaluate the genetic susceptibility that affects sepsis outcome in 72 sepsis patients admitted to the ICU. Seven polymorphisms were genotyped in key inflammatory response genes in sepsis, including tumour necrosis factor-?, interlelukin (IL)-1?, IL-10, IL-8, Toll-like receptor 4, CXCR1 and CXCR2. The primary finding showed that patients who were homozygous for the major A allele in IL-10 rs1800896 had almost five times higher chance to develop septic shock compared to heterozygotes. Similarly, selected clinical features and CXCR2 rs1126579 single nucleotide polymorphisms modulated septic shock susceptibility without affecting survival. These data support the hypothesis that molecular testing has clinical usefulness to improve sepsis prognostic models. Therefore, enrichment of the ICU portfolio by including these biomarkers will aid in the early identification of sepsis patients who may develop septic shock. PMID:26038959

  5. 10 CFR 434.103 - Referenced standards (RS).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... false Referenced standards (RS). 434.103 Section 434.103 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CODE FOR NEW FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH RISE RESIDENTIAL BUILDINGS Administration and...

  6. 10 CFR 434.103 - Referenced standards (RS).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... false Referenced standards (RS). 434.103 Section 434.103 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CODE FOR NEW FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH RISE RESIDENTIAL BUILDINGS Administration and...

  7. G IS ,,,, (~' G IS RS -- 210093) (~'--,,fiL...--" 210093)

    E-print Network

    Li, Xiang

    G IS °Æ,,,, × / (~'·§ G IS º RS --¿¸ø¡¡ 210093) ¡¡ (~'·§°--,,»fiL...--¿"¡¡ 210093) ¡""¡¿ ­~°¨Ø`¸¤`¢°--´,,l G IS ~­"-- , ¨»"·`¸¸ø--L°Æ,,,," , ¢Æ»° ^~°--´,,l G IS °Æ,,,, , ¨¶--»--',°l----`¸--¿ , ~´"¶­°Æ,,,,--·~»--' °l----`¸´¡£ ¡,,...¡¿ ´,,l¡¡ G IS¡¡°Æ,,,,¡¡¨

  8. Discovery of three new RS Canum Venaticorum-like counterparts to HEAO I X-ray sources

    NASA Technical Reports Server (NTRS)

    Buckley, D. A. H.; Tuohy, I. R.; Remillard, R. A.; Bradt, H. V.; Schwartz, D. A.

    1987-01-01

    The identification of three high-latitude HEAO I Scanning Modulation Collimator X-ray sources with the chromospherically active RS CVn-like stars HD 113816, HD 146413, and HD 39576 is reported. Optical observations, including coude spectroscopy and broad-band and narrow band photoelectric photometry are presented. The Ca II emission strength of all three stars shows that they are chromospherically active. HD 146413 and HD 39576 exhibit variable X-ray emission in the 1-13 keV energy range, while HD 113816 is a softer and steadier source. The level of X-ray flux detected from these three stars is some one to two orders of magnitude higher than predicted empirically from the Ca II emission fluxes. It is proposed that this emission results from flarelike activity.

  9. Prognostic significance of interleukin-6 single nucleotide polymorphism genotypes in neuroblastoma: rs1800795 (promoter) and rs8192284 (receptor)

    PubMed Central

    Lagmay, Joanne P.; London, Wendy B.; Gross, Thomas G.; Termuhlen, Amanda; Sullivan, Nicholas; Axel, Amy; Mundy, Bethany; Ranalli, Mark; Canner, Jason; McGrady, Patrick; Hall, Brett

    2009-01-01

    Purpose Neuroblastoma is a childhood cancer of the sympathetic nervous system and many patients present with high risk disease. Risk stratification, based on pathology and tumor-derived biomarkers, has improved prediction of clinical outcomes, but overall survival rates remain unfavorable and new therapeutic targets are needed. Some studies suggest a link between interleukin-6 and more aggressive behavior in neuroblastoma tumor cells. Therefore, we examined the impact of two IL-6 single nucleotide polymorphisms (SNP) on neuroblastoma disease progression. Experimental design DNA samples from 96 high risk neuroblastoma patients were screened for two SNP that are known to regulate the serum levels of IL-6 and the soluble IL-6 receptor (IL-6R), rs1800795 and rs8192284 respectively. The genotype for each SNP was determined in a blinded fashion and independent statistical analysis was performed to determine SNP-related event free survival (EFS) and overall survival (OS) rates. Results The rs1800795 IL-6 promoter SNP is an independent prognostic factor for EFS and OS in -high risk neuroblastoma patients. In contrast, the rs8192284 IL-6 receptor SNP revealed no prognostic value. Conclusions The rs1800795 SNP (-174 IL-6 (G>C) represents a novel and independent prognostic marker for both EFS and OS in high risk neuroblastoma. Since the rs1800795 SNP (-174 IL-6 (G>C) has been shown to correlate with production of IL-6, this cytokine may represent a target for development of new therapies in neuroblastoma. PMID:19671870

  10. Association of SNPs in GHSR rs292216 and rs509035 on dietary intake in Indonesian obese female adolescents

    PubMed Central

    Luglio, Harry Freitag; Inggriyani, Cut Gina; Huriyati, Emy; Julia, Madarina; Susilowati, Rina

    2014-01-01

    Background: Obesity has been linked to high dietary intake and low physical activity. Studies showed that those factors were not only regulated by environment but also by genetic. However, the relationship is less been understood in obese children and adolescents. Objective: The objective of this study was to examine the role of SNPs in GHSR rs292216 and rs509035 on dietary intake in obese female adolescents. Methods: This is an observational study with cross sectional design. Respondents were obese female adolescents enrolled from obesity screening done in six junior high schools in Yogyakarta. Dietary intake was measured using 6 days 24 hours inconsecutive dietary recall. Genotyping of 2 SNPs from GHSR was done using FRLP-PCR. Results: There were 78 obese female adolescents joined this study. We found that no significant association between SNPs GHSR and dietary intake (p < 0.05). In addition, a SNP-SNP interaction analysis shown there is no difference between combination of GHSR rs292216 and rs509035 on dietary intake (p < 0.05). Conclusion: We concluded that SNPs on GHSR rs292216 and rs509035 were not related to dietary intake in Indonesian obese female adolescents. Further study is necessary to investigate the effect of those genes on dietary intake in the broader population. PMID:25755847

  11. Optical flickering of the recurrent nova RS Ophiuchi: amplitude-flux relation

    NASA Astrophysics Data System (ADS)

    Zamanov, R.; Latev, G.; Boeva, S.; Sokoloski, J. L.; Stoyanov, K.; Bachev, R.; Spassov, B.; Nikolov, G.; Golev, V.; Ibryamov, S.

    2015-07-01

    We report observations of the flickering variability of the symbiotic recurrent nova RS Oph at quiescence in five bands (UBVRI). We find evidence of a correlation between the peak-to-peak flickering amplitude (?F) and the average flux of the hot component (Fav). The correlation is highly significant, with a correlation coefficient of 0.85 and a p-value of ˜10-20. Combining the data from all wavebands, we find a dependence of the type ? F ? F_{av}^k, with power-law index k = 1.02 ± 0.04 for the UBVRI flickering of RS Oph. Thus, the relationship between the amplitude of variability and the average flux of the hot component is consistent with linearity. The rms amplitude of flickering is on average 8 per cent (±2 per cent) of Fav. The detected correlation is similar to that found in accreting black holes/neutron stars and cataclysmic variables. The possible reasons are briefly discussed. The data are available upon request from the authors.

  12. Limb xenotransplantation using FK506 and RS61443 immunosuppression.

    PubMed

    Hebebrand, D; Jones, N F; Zohman, G; Rao, U; Soleiman, N

    1998-04-01

    A new model of limb xenotransplantation has been developed to determine whether the newer immunosuppressive agents, FK-506 and RS-61443, either alone or in combination, can delay the rejection of a composite limb xenograft from donor Golden Syrian hamsters to recipient Lewis rats. Using a short-term course of immunosuppression for 14 days post-transplant, both FK-506 2 mg/kg/day and RS-61443 30 mg/kg/day were able to delay rejection. FK-506-treated animals had a mean rejection time of 10.2 days and RS-61443-treated animals had a mean rejection time of 10 days, compared with a mean rejection time of 6.4 days in non-immunosuppressed controls. Combination and sequential immunosuppression with both FK-506 and RS-61443 did not produce any improvement, compared with single-agent immunosuppression, and were quite toxic. Histologically, FK-506 seemed to prevent signs of rejection in the skin and muscle components of the limb xenograft better than RS-61443. PMID:9590615

  13. Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report.

    PubMed

    Hashemi, Mohammad; Rezaei, Hamzeh; Eskandari-Nasab, Ebrahim; Kaykhaei, Mahmoud Ali; Zakeri, Zahra; Taheri, Mohsen

    2012-12-01

    Metabolic syndrome (MeS) is associated with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease. There is some evidence indicating that adipokines play a role in the development of MeS. The present study was aimed to investigate the impact of chemerin rs17173608 and vaspin rs2236242 gene polymorphisms with the risk of MeS in a sample of Iranian population. This case-control study was done on 151 subjects with MeS and 149 without MeS, as defined by NCEP-ATPIII. Tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) was designed to detect the polymorphisms. Our finding showed that there are significant differences in genotype frequencies between the groups regarding vaspin rs2236242 polymorphism (?(2)=18.74, p<0.0001). A significant protection against MeS was found for vaspin rs2236242 in allele and genotypes (Odd Ratio [OR]=0.52; 95% confidence interval [CI]=0.37-0.72; p=0.0001, T vs A; OR=0.49; 95%CI=0.29-0.82; p=0.007, TT vs TA and OR=0.17; 95%CI=0.07-0.40; p<0.0001, TT vs AA). Our finding showed positive association between chemerin rs17173608 polymorphism and risk of MeS (?(2)=7.70, p=0.021). The G allele increased the risk of MeS (OR=1.78; 95% CI=1.14-2.78; p=0.012) as compared to the T allele. In conclusion, our data suggest for the first time a significant association between vaspin rs2236242 and chemerin rs17173608 polymorphisms and the MeS in Zahedan, southeast Iran. Further studies with large sample size and different ethnicities are required to confirm our findings. PMID:22982016

  14. Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.

    PubMed Central

    Chan, J Y; Kwong, M; Lu, R; Chang, J; Wang, B; Yen, T S; Kan, Y W

    1998-01-01

    The CNC-basic leucine zipper (CNC-bZIP) family is a subfamily of bZIP proteins identified from independent searches for factors that bind the AP-1-like cis-elements in the beta-globin locus control region. Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1 and Nrf-2 are expressed in a wide range of tissues. To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero. PMID:9501099

  15. Luminescent Ruthenium(II) Complex Bearing Bipyridine and N-Heterocyclic Carbene-based C?N?C Pincer Ligand for Live-Cell Imaging of Endocytosis

    NASA Astrophysics Data System (ADS)

    Tsui, Wai-Kuen; Chung, Lai-Hon; Wong, Matthew Man-Kin; Tsang, Wai-Him; Lo, Hoi-Shing; Liu, Yaxiang; Leung, Chung-Hang; Ma, Dik-Lung; Chiu, Sung-Kay; Wong, Chun-Yuen

    2015-03-01

    Luminescent ruthenium(II)-cyanide complex with N-heterocyclic carbene pincer ligand C?N?C = 2,6-bis(1-butylimidazol-2-ylidene)pyridine and 2,2'-bipyridine (bpy) shows minimal cytotoxicity to both human breast carcinoma cell (MCF-7) and human retinal pigmented epithelium cell (RPE) in a wide range of concentration (0.1-500 ?M), and can be used for the luminescent imaging of endocytosis of the complex in these cells.

  16. Strange stars

    NASA Technical Reports Server (NTRS)

    Alcock, Charles; Farhi, Edward; Olinto, Angela

    1986-01-01

    Strange matter, a form of quark matter that is postulated to be absolute stable, may be the true ground stage of the hadrons. If this hypothesis is correct, neutron stars may convert to 'strange stars'. The mass-radius relation for strange stars is very different from that of neutron stars; there is no minimum mass, and for mass of 1 solar mass or less, mass is proportional to the cube of the radius. For masses between 1 solar mass and 2 solar masses, the radii of strange stars are about 10 km, as for neutron stars. Strange stars may have an exposed quark surface, which is capable of radiating at rates greatly exceeding the Eddington limit, but has a low emissivity for X-ray photons. The stars may have a thin crust with the same composition as the preneutron drip outer layer of a conventional neutron star crust. Strange stars cool efficiently via neutrino emission.

  17. Ralf Klessen: Lecture 3: 29.12.2006 From clouds to stars

    E-print Network

    Klessen,Ralf

    : Lecture 3: 29.12.2006 Literature (update) Star Formation: Stahler, S., & Palla, F., 2004, "The Formation) Review articles: Mac Low, M.-M., Klessen, R.S., 2004, "The control of star formation by supersonic, 23 - 81 Protostars and Planets V (new review book): articles at http://www2.ifa

  18. Possible selective formation of CNC/sup +/ and CCN/sup +/ in the interstellar reactions of C/sup +/ with HCN and HNC/sup +/

    SciTech Connect

    Haese, N.N.; Woods, R.C.

    1981-05-15

    The molecular structures of CNC/sup +/ and CCN/sup +/ have been determined by double zeta self-consistent field (SCF) calculations. Their standard heats of formation are theoretically estimated to be 372 +- 20 and 421 +- 25 kcal mol/sup -1/, respectively, the latter determined by double zeta plus polarization SCF-CI (configuration interaction) calculation of the isomerization energy for CNC/sup +/..-->..CCN/sup +/. Using these results, the available appearance potential data for these ions in the mass spectra of HC/sub 3/N and C/sub 2/N/sub 2/ can be explained by simple reactions, and the numerical agreement between the corresponding experimental and theoretical heats of formation is excellent. With this thermochemical information and mechanistic considerations of C/sup +/ reactions with HCN and HNC, we propose that CNC/sup +/ may be selectively made from HCN, and CCN/sup +/ from HNC, and that this selectivity may play an important role in the chemistry of the interstellar medium. For the polar isomer CCN/sup +/ we report an SCF prediction of its rotational constant (11.93 +- 0.5 GHz) and a higher-level (CI) calculation of its electric dipole moment (2.50 +- 0.2 debye) and nitrogen nuclear quadrupole coupling constant (-4.95 +- 0.5 MHz).

  19. Association of Versican (VCAN) gene polymorphisms rs251124 and rs2287926 (G428D), with intracranial aneurysm.

    PubMed

    Sathyan, Sanish; Koshy, Linda V; Balan, Shabeesh; Easwer, H V; Premkumar, S; Nair, Suresh; Bhattacharya, R N; Alapatt, Jacob P; Banerjee, Moinak

    2014-12-01

    Intracranial aneurysm (IA) accounts for 85% of Subarachnoid Hemorrhage (SAH) and is mainly caused due to the weakening of arterial wall. The structural integrity of the intracranial arteries is mainly influenced by the extracellular matrix (ECM) remodeling. The Proteoglycan Versican plays an important role in extracellular matrix assembly and plays a major role in the pathogenesis of IA. The linkage studies also indicated VCAN as a putative candidate gene for IA in the 5q22-31 region. Using a case-control study design, we tested the hypothesis whether the variants in VCAN gene, nonsynonymous variants in the coding region of Glycosaminoglycan ? (GAG-?) and GAG-? and two reported SNPs involved in splicing rs251124 and rs173686 can increase the risk of aSAH among South Indian patients, either independently, or by interacting with other risk factors of the disease. We selected 200 radiologically confirmed aneurysmal cases and 250 ethnically, age and sex matched controls from the Dravidian Malayalam speaking population of South India. The present study reiterated the earlier association of rs251124 with intracranial aneurysm (P = 0.0002) and also found a novel association with rs2287926 (G428D) in exon 7 coding for GAG-? with intracranial aneurysm (P = 0.0015). Interestingly, both these SNPs contributed to higher risk for aneurysm in males. In-silico analysis predicted this SNP to have the highest functional relevance in the gene which might have a potentially altered regulatory role in transcription and splicing. Using meta-analysis with available literature rs251124 was found to be the strongest intracranial aneurysm marker for global ethnicities. This study with a novel functional SNP rs2287926 (G428D) further substantiates the potential role of VCAN in the pathogenesis of IA. PMID:25606449

  20. Association of Versican (VCAN) gene polymorphisms rs251124 and rs2287926 (G428D), with intracranial aneurysm

    PubMed Central

    Sathyan, Sanish; Koshy, Linda V.; Balan, Shabeesh; Easwer, H.V.; Premkumar, S.; Nair, Suresh; Bhattacharya, R.N.; Alapatt, Jacob P.; Banerjee, Moinak

    2014-01-01

    Intracranial aneurysm (IA) accounts for 85% of Subarachnoid Hemorrhage (SAH) and is mainly caused due to the weakening of arterial wall. The structural integrity of the intracranial arteries is mainly influenced by the extracellular matrix (ECM) remodeling. The Proteoglycan Versican plays an important role in extracellular matrix assembly and plays a major role in the pathogenesis of IA. The linkage studies also indicated VCAN as a putative candidate gene for IA in the 5q22–31 region. Using a case–control study design, we tested the hypothesis whether the variants in VCAN gene, nonsynonymous variants in the coding region of Glycosaminoglycan ? (GAG-?) and GAG-? and two reported SNPs involved in splicing rs251124 and rs173686 can increase the risk of aSAH among South Indian patients, either independently, or by interacting with other risk factors of the disease. We selected 200 radiologically confirmed aneurysmal cases and 250 ethnically, age and sex matched controls from the Dravidian Malayalam speaking population of South India. The present study reiterated the earlier association of rs251124 with intracranial aneurysm (P = 0.0002) and also found a novel association with rs2287926 (G428D) in exon 7 coding for GAG-? with intracranial aneurysm (P = 0.0015). Interestingly, both these SNPs contributed to higher risk for aneurysm in males. In-silico analysis predicted this SNP to have the highest functional relevance in the gene which might have a potentially altered regulatory role in transcription and splicing. Using meta-analysis with available literature rs251124 was found to be the strongest intracranial aneurysm marker for global ethnicities. This study with a novel functional SNP rs2287926 (G428D) further substantiates the potential role of VCAN in the pathogenesis of IA. PMID:25606449

  1. Variable Stars Pulsating Stars: periodic

    E-print Network

    Basu, Shantanu

    Variable Stars · Pulsating Stars: periodic expansion and contraction, e.g., Cepheids, RR Lyrae increases . Why? #12;Pulsating Stars Cepheid variables: giant stars, very luminous Type II Cepheids: lower Z's · Catacylsmic and Eruptive Variables: sudden large changes, e.g., novae and supernovae · Others: changes

  2. INFeRS: Interactive Numeric Files Retrieval System. Final Report.

    ERIC Educational Resources Information Center

    Chiang, Katherine; And Others

    In 1988 Mann Library at Cornell University proposed to develop a computer system that would support interactive access to significant electronic files in agriculture and the life sciences. This system was titled the Interactive Numeric Files Retrieval System (INFeRS). This report describes how project goals were met and it presents the project's…

  3. Role of miRs in Cardiac Preconditioning

    PubMed Central

    Salloum, Fadi N.; Yin, Chang; Kukreja, Rakesh C.

    2014-01-01

    Preconditioning of the heart by sub-lethal ischemia, mild heat shock or hypoxia have evolved as powerful experimental tools to discover novel signaling mechanisms in cardioprotection. The ultimate goal is to determine novel therapeutic targets for potential application in humans in protecting the heart against ischemia-related injuries. In recent years, there has been a tremendous interest in understanding the role of small non-coding RNAs, microRNAs (miRs), in cardiovascular diseases. miRs have been recognized as regulators of gene expression by destabilization and translational inhibition of target mRNAs. Studies have shown that several miRs including miR-1, miR-133, miR-21, miR-126, miR-320, miR-92a and miR-199a are regulated after preconditioning and play an active role in protection of the heart against ischemia/reperfusion injury. These miRs also drive the synthesis of important cardioprotective proteins including HSP-70, eNOS, iNOS, HSP-20, Sirt-1 and HIF-1?. We believe that identification and targeted delivery of miR(s) in the heart could have an immense therapeutic potential in reducing myocardial infarction in patients suffering from heart disease. PMID:20980922

  4. Quantitative Evaluation of Pairs and RS Steganalysis Andrew D. Ker

    E-print Network

    Ker, Andrew

    here is on the Pairs and RS methods, for detection of simple LSB steganography in grayscale bitmaps, and resampled cover images. Keywords: Steganography, Steganalysis 1. INTRODUCTION: STEGANOGRAPHY AND STEGANALYSIS The aim of steganography is to transmit hidden data embedded in a cover medium, in such a way

  5. 359-06/RDS/rs PERSISTENT SURVEILLANCE FOR

    E-print Network

    -700 0C) heat extraction ­ Complex neutronics issues ­ Tritium breeding ratio > 1.0 ­ Chemistry effects/rs The Fusion Development Facility Mission: Develop Fusion's Energy Applications · Develop the technology to make ­ Tritium ­ Electricity ­ Hydrogen · By using conservative Advanced Tokamak physics to run steady

  6. Is there the radion in the RS2 model?

    NASA Astrophysics Data System (ADS)

    Smolyakov, Mikhail; Volobuev, Igor

    2004-03-01

    We analyse the physical boundary conditions at infinity for metric fluctuations and gauge functions in the RS2 model with matter on the brane. We argue that due to these boundary conditions the radion field cannot be gauged out in this case. Thus, it represents a physical degree of freedom of the model.

  7. OPMILL - MICRO COMPUTER PROGRAMMING ENVIRONMENT FOR CNC MILLING MACHINES THREE AXIS EQUATION PLOTTING CAPABILITIES

    NASA Technical Reports Server (NTRS)

    Ray, R. B.

    1994-01-01

    OPMILL is a computer operating system for a Kearney and Trecker milling machine that provides a fast and easy way to program machine part manufacture with an IBM compatible PC. The program gives the machinist an "equation plotter" feature which plots any set of equations that define axis moves (up to three axes simultaneously) and converts those equations to a machine milling program that will move a cutter along a defined path. Other supported functions include: drill with peck, bolt circle, tap, mill arc, quarter circle, circle, circle 2 pass, frame, frame 2 pass, rotary frame, pocket, loop and repeat, and copy blocks. The system includes a tool manager that can handle up to 25 tools and automatically adjusts tool length for each tool. It will display all tool information and stop the milling machine at the appropriate time. Information for the program is entered via a series of menus and compiled to the Kearney and Trecker format. The program can then be loaded into the milling machine, the tool path graphically displayed, and tool change information or the program in Kearney and Trecker format viewed. The program has a complete file handling utility that allows the user to load the program into memory from the hard disk, save the program to the disk with comments, view directories, merge a program on the disk with one in memory, save a portion of a program in memory, and change directories. OPMILL was developed on an IBM PS/2 running DOS 3.3 with 1 MB of RAM. OPMILL was written for an IBM PC or compatible 8088 or 80286 machine connected via an RS-232 port to a Kearney and Trecker Data Mill 700/C Control milling machine. It requires a "D:" drive (fixed-disk or virtual), a browse or text display utility, and an EGA or better display. Users wishing to modify and recompile the source code will also need Turbo BASIC, Turbo C, and Crescent Software's QuickPak for Turbo BASIC. IBM PC and IBM PS/2 are registered trademarks of International Business Machines. Turbo BASIC and Turbo C are trademarks of Borland International.

  8. Modulation of central noradrenergic function by RS-15385-197.

    PubMed Central

    Redfern, W. S.; MacKinnon, A. C.; Brown, C. M.; Martin, A. B.; Kilpatrick, A. T.; Clague, R. U.; Spedding, M.

    1993-01-01

    1. RS-15385-197, a highly potent and selective alpha 2-adrenoceptor antagonist, was examined in a variety of in vitro and in vivo functional tests to assess the selectivity of its interaction with central noradrenergic neurones in the rat. 2. In hypothalamic slices, RS-15385-197 was potent in augmenting K(+)-evoked release of [3H]-noradrenaline, with an EC50 of 9 nM. Idazoxan and yohimbine showed 100 fold less activity. This was due to its antagonist action at presynaptic alpha 2-adrenoceptors, as RS-15385-197 (10 microM), did not directly release [3H]-noradrenaline from cortical slices unlike reserpine (10 microM), and did not inhibit noradrenaline re-uptake into cortical synaptosomes. 3. In vivo, RS-15385-197 (0.5 mg kg-1, p.o.) increased levels of 3-methoxy-4-hydroxy-phenylglycol (MHPG) in the cerebral cortex without modifying levels of 5-hydroxyindoleacetic acid (5-HIAA). This dose, but not a lower dose (0.1 mg kg-1, p.o.) caused beta-adrenoceptor down-regulation in the cortex when administered once daily for 14 days whereas 5-HT2 receptor number was unaltered, indicating a selective effect on noradrenergic transmission. 4. Selective depletion of cortical 5-HT by administration of p-chlorophenylalanine (PCPA; 100 mg kg-1, i.p. for 14 days) or 5,7-dihydroxytryptamine (5,7-DHT; 150 micrograms i.c.v.) prevented the beta-adrenoceptor down-regulation caused by RS-15385-197, indicating that a tonic 5-hydroxytryptaminergic input was required for it to elicit beta-adrenoceptor down-regulation.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8095421

  9. Evidence for a New Dust Creation Paradigm in Recurrent Novae: Milliarcsecond Resolution Mid-Infrared Observations of RS Ophiuchi

    NASA Astrophysics Data System (ADS)

    Danchi, W. C.; Barry, R. K.; Traub, W. A.; Sokoloski, J. L.; Wisniewski, J. P.; Serabyn, E.; Kuchner, M. J.

    2009-02-01

    We report observations of the nova RS Ophiuchi (RS Oph) using the Keck Interferometer Nuller (KIN), approximately 3.8 days following the most recent outburst of 2006 February 12. These observations represent the first scientific results from the KIN, which operates in N-band from 8 to 12.5 ?m in a nulling mode. In this mode the stellar light itself is suppressed by a destructive fringe, effectively enhancing the contrast of any nearby (constructive fringe) source, which in this case is the circumstellar material located near the star. By fitting the unique KIN data, we have obtained an angular size of the mid-infrared continuum of 6.2+/-0.6, 4.0+/-0.4, or 5.4+/-0.6 mas for disk, gaussian (FWHM), and shell profiles, respectively. The data show evidence of enhanced neutral atomic hydrogen emission and atomic metals including silicon located in the inner spatial regime (<5 AU) near the white dwarf (WD) relative to the outer regime. There are also nebular emission lines and evidence of hot silicate dust in the outer spatial region, centered at about 17 AU from the WD that are not found in the inner regime. Our evidence suggests that these features have been excited by the nova flash in the outer spatial regime before the blast wave reached these regions, in support a model in which the dust appears to be present between outbursts. The present results are consistent with a unifying model of the system that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star.

  10. Milliarcsecond N-Band Observations of the Nova RS Ophiuchi: First Science with the Keck Interferometer Nuller

    NASA Astrophysics Data System (ADS)

    Barry, R. K.; Danchi, W. C.; Traub, W. A.; Sokoloski, J. L.; Wisniewski, J. P.; Serabyn, E.; Kuchner, M. J.; Akeson, R.; Appleby, E.; Bell, J.; Booth, A.; Brandenburg, H.; Colavita, M.; Crawford, S.; Creech-Eakman, M.; Dahl, W.; Felizardo, C.; Garcia, J.; Gathright, J.; Greenhouse, M. A.; Herstein, J.; Hovland, E.; Hrynevych, M.; Koresko, C.; Ligon, R.; Mennesson, B.; Millan-Gabet, R.; Morrison, D.; Palmer, D.; Panteleeva, T.; Ragland, S.; Shao, M.; Smythe, R.; Summers, K.; Swain, M.; Tsubota, K.; Tyau, C.; Wetherell, E.; Wizinowich, P.; Woillez, J.; Vasisht, G.

    2008-04-01

    We report observations of the nova RS Ophiuchi (RS Oph) using the Keck Interferometer Nuller (KIN), approximately 3.8 days following the most recent outburst that occurred on 2006 February 12. These observations represent the first scientific results from the KIN, which operates in N band from 8 to 12.5 ?m in a nulling mode. The nulling technique is the sparse aperture equivalent of the conventional coronagraphic technique used in filled aperture telescopes. In this mode the stellar light itself is suppressed by a destructive fringe, effectively enhancing the contrast of the circumstellar material located near the star. By fitting the unique KIN data, we have obtained an angular size of the mid-infrared continuum emitting material of 6.2, 4.0, or 5.4 mas for a disk profile, Gaussian profile (FWHM), and shell profile, respectively. The data show evidence of enhanced neutral atomic hydrogen emission and atomic metals including silicon located in the inner spatial regime near the white dwarf (WD) relative to the outer regime. There are also nebular emission lines and evidence of hot silicate dust in the outer spatial region, centered at ~17 AU from the WD, that are not found in the inner regime. Our evidence suggests that these features have been excited by the nova flash in the outer spatial regime before the blast wave reached these regions. These identifications support a model in which the dust appears to be present between outbursts and is not created during the outburst event. We further discuss the present results in terms of a unifying model of the system that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star.

  11. Milliarcsecond N-Band Observations of the Nova RS Ophiuchi: First Science with the Keck Interferometer Nuller

    E-print Network

    R. K. Barry; W. C. Danchi; W. A. Traub; J. L. Sokoloski; J. P. Wisniewski; E. Serabyn; M. J. Kuchner; R. Akeson; E. Appleby; J. Bell; A. Booth; H. Brandenburg; M. Colavita; S. Crawford; M. Creech-Eakman; W. Dahl; C. Felizardo; J. Garcia; J. Gathright; M. A. Greenhouse; J. Herstein; E. Hovland; M. Hrynevych; C. Koresko; R. Ligon; B. Mennesson; R. Millan-Gabet; D. Morrison; D. Palmer; T. Panteleeva; S. Ragland; M. Shao; R. Smythe; K. Summers; M. Swain; K. Tsubota; C. Tyau; G. Vasisht; E. Wetherell; P. Wizinowich; J. Woillez

    2008-01-27

    We report observations of the nova RS Ophiuchi (RS Oph) using the Keck Interferometer Nuller (KIN), approximately 3.8 days following the most recent outburst that occurred on 2006 February 12. These observations represent the first scientific results from the KIN, which operates in N-band from 8 to 12.5 microns in a nulling mode. By fitting the unique KIN data, we have obtained an angular size of the mid-infrared continuum of 6.2, 4.0, or 5.4 mas for a disk profile, gaussian profile (FWHM), and shell profile respectively. The data show evidence of enhanced neutral atomic hydrogen emission and atomic metals including silicon located in the inner spatial regime near the white dwarf (WD) relative to the outer regime. There are also nebular emission lines and evidence of hot silicate dust in the outer spatial region, centered at ! 17 AU from the WD, that are not found in the inner regime. Our evidence suggests that these features have been excited by the nova flash in the outer spatial regime before the blast wave reached these regions. These identifications support a model in which the dust appears to be present between outbursts and is not created during the outburst event. We further discuss the present results in terms of a unifying model of the system that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star. These data show the power and potential of the nulling technique which has been developed for the detection of Earth-like planets around nearby stars for the Terrestrial Planet Finder Mission and Darwin missions.

  12. Pulsating Stars

    NASA Astrophysics Data System (ADS)

    Catelan, M.; Smith, H. A.

    2015-03-01

    This book surveys our understanding of stars which change in brightness because they pulsate. Pulsating variable stars are keys to distance scales inside and beyond the Milky Way galaxy. They test our understanding not only of stellar pulsation theory but also of stellar structure and evolution theory. Moreover, pulsating stars are important probes of the formation and evolution of our own and neighboring galaxies. Our understanding of pulsating stars has greatly increased in recent years as large-scale surveys of pulsating stars in the Milky Way and other Local Group galaxies have provided a wealth of new observations and as space-based instruments have studied particular pulsating stars in unprecedented detail.

  13. 40 CFR 180.1114 - Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    742RS are exempted from the requirement of a tolerance in or on all raw agricultural commodities when applied as a frost protection agent or biological control agent to growing agricultural crops in accordance with good agricultural practices. [57 FR 42700, Sept. 16,...

  14. Intermittent process measurement and process capability analysis using MP700 touch trigger probe on a CNC machining center

    NASA Astrophysics Data System (ADS)

    Shiou, Fang-Jung; Su, Po-Chuan

    2006-11-01

    This study developed an intermittent process measurement system by integrating a MP700 touch trigger probe system with a machining center to measure a workpiece containing freeform surface and regular geometric features, and to do the statistical process control analysis. The whole measuring system, consisting of a personal computer, a CNC machining center controller, a RENISHAW MP700 touch probe system, was integrated information-technically. Measuring software was also developed to simulate the measuring path, to prevent collision, to generate the corresponding measuring NC codes and to calculate the process capability indices, such as the process capability index (Cp), the process performance index (C PK) and the accuracy capability index (Ca). To evaluate the performance of the developed measuring system, a carrier combined with a freeform surface and regular geometric features, referred to in the ISO 10791-7 cutting test standard, was designed. Six pieces of the tested carriers were manufactured and inspected using the MP700 touch trigger probe to evaluate the performance of the developed measuring system. According to the measuring results, the developed measuring system was successfully and effectively used to carry out the intermittent process measurement and the statistical process analysis of the measuring results of some test carriers on the machining center.

  15. Radial velocity planets de-aliased. A new, short period for Super-Earth 55 Cnc e

    E-print Network

    Dawson, Rebekah I

    2010-01-01

    Radial velocity measurements of stellar reflex motion have revealed many extra-solar planets, but gaps in the observations produce aliases, spurious frequencies that are frequently confused with the planets' orbital frequencies. In the case of Gl 581d, the distinction between an alias and the true frequency was the distinction between a dead, frozen planet and a planet likely hospitable to life (Udry et al. 2007; Mayor et al. 2009). To improve the characterization of planetary systems, we describe how aliases originate and present a new approach for distinguishing between orbital frequencies and their aliases. Our approach harnesses features in the spectral window function to compare the amplitude and phase of predicted aliases with peaks present in the data. We apply it to confirm prior alias distinctions for the planets GJ 876d and HD 75898b. We find that the true periods of Gl 581c and HD 73526b/c remain ambiguous. We revise the periods of HD 156668b and 55 Cnc e, which were afflicted by daily aliases. For...

  16. Tidal dissipation and eccentricity pumping: Implications for the depth of the secondary eclipse of 55 Cnc e

    E-print Network

    Bolmont, Emeline; Raymond, Sean N; Leconte, Jeremy; Hersant, Franck; Maurin, Anne-Sophie; Pericaud, Jessica

    2013-01-01

    We use the super Earth 55 Cnc e as a case study to address an observable effect of tidal heating. We investigate whether planet-planet interactions can force the eccentricity of this planet to a level affecting the eclipse depth observed with Spitzer. Using the constant time lag tidal model, we first calculate the observed planet flux as a function of albedo and eccentricity, for different tidal dissipation constants and for two extreme cases: a planet with no heat redistribution and a planet with full heat redistribution. We derive the values of albedo and eccentricity that match the observed transit depth. We then perform N-body simulations of the planetary system including tides and General Relativity to follow the evolution of the eccentricity of planet e. We compare the range of eccentricities given by the simulations with the eccentricities required to alter the eclipse depth. We find that the eccentricity of planet e can be large enough to contribute at a measurable level to the thermal emission measur...

  17. Synthetic Direct Impact Light Curves of the Ultracompact AM CVn Binary Systems V407 Vul and HM Cnc

    E-print Network

    Wood, Matt A

    2009-01-01

    The interacting binary white dwarf (AM CVn) systems HM Cnc and V407 have orbital periods of 5.4 min and 9.5 min, respectively. The two systems are characterized by an "on/off" behaviour in the X-ray light curve, and optical light curves that are nearly sinusoidal and which lead the X-ray light curves in phase by about 0.2 in both systems. Of the models that have been proposed to explain the observations, the one that seems to require the least fine tuning is the direct impact model of Marsh & Steeghs (2002). In this model, the white dwarf primary is large enough relative to the semi-major axis that the accretion stream impacts the surface of the primary white dwarf directly without forming an accretion disc. Marsh & Steeghs proposed that in this situation there could be a flow set up around the equator with a decreasing surface temperature the further one measured from the impact point. In this study, we estimate the light curves that might result from such a temperature distribution, and find them to...

  18. Investigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with multiple sclerosis of Azerbaijan, Northwest Iran

    PubMed Central

    Gharibi, Tohid; Kazemi, Tohid; Aliparasti, Mohammad Reza; Farhoudi, Mehdi; Almasi, Shohreh; Dehghanzadeh, Rashedeh; seyfizadeh, Narges; Babaloo, Zohreh

    2015-01-01

    Background: Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the Central Nervous System that is immunologically mediated in genetically susceptible individuals. IL-21, a cytokine produced by TCD4+ cells, particularly by Th-17 cells, is believed to play an important role in the MS pathogenesis. Objective: This study was performed to investigate the impact of genetic polymorphisms in IL-21 gene on MS susceptibility and clinical profiles. Methods: Seventy Iranian patients with clinically definite relapsing-remitting MS and 110 age, sex and ethic matched controls were genotyped for IL-21 gene polymorphisms using PCR-RFLP method. Results: Our results showed that the IL-21 rs2221903 SNP is not polymorphic in our population. Also, the allelic and genotypic frequencies of the IL-21 rs2055979 did not differ significantly between the MS patients and controls (P = 0.413 and P = 0.565 respectively, and OR = 1.122, 95% CI = 0.79-1.87 for T allele). However, our results showed that IL-21 rs2055979 (G/T) T allele positive (TT+GT) MS patients had lower (PI ? 1.5) disease progression compared to rs2055979 T allele negative (GG) patients (P = 0.009). Conclusion: Our results showed that no outstanding association exists between IL-21 alleles and susceptibility to MS. However, our clinical analysis showed significant association of IL-21 gene polymorphism with the progression of multiple sclerosis disease. Our results indicate that the G allele promotes, or the T allele protects against disease progression. To clarify the role of IL-21 rs2055979 in MS pathogenesis, further comprehensive studies with larger sample sizes among different ethnicity populations are recommended. PMID:26155434

  19. Association of rs5368 and rs3917406 polymorphisms in E-selectin gene with premature coronary artery disease in Chinese Han population

    PubMed Central

    Shan, Hongwei; Zhang, Min; Zhang, Mingduo; Liu, Xin; Song, Xiantao; Yin, Xunli; Lv, Shuzheng

    2015-01-01

    Objectives: Genetics polymorphism of the E-selectin affects the pathogenesis of atherosclerosis and associated with coronary artery disease (CAD). We aimed to investigate the association between the rs5368 and rs3917406 polymorphisms in E-selectin genes and premature CAD (PCAD) in Chinese Han population. Methods: PCAD 628 patients and 732 controls were included in the study. E-selectin of rs5368 and rs3917406 polymorphisms were analyzed by polymerase chain reaction (PCR). Results: The frequencies of T allele of the rs5368 and rs3917406 polymorphisms were 27.2% and 47.8%, respectively, in the PCAD group, and 30.5% and 42.8% in the control group. The frequency of the T allele of the rs3917406 polymorphism was significantly higher in the PCAD group than in the control group (x2 = 6.857, P = 0.009). In contrast, no statistically significant difference was found between controls and patients in the frequency of T allele of the rs5368 polymorphism. The univariate analysis showed that the E-selectin rs3917406 polymorphisms was associated with the PCAD in additive model (OR = 1.226, 95% CI = 1.05-1.43, P = 0.010) and dominant model (OR = 1.406, 95% CI = 1.11-1.78, P = 0.005). After adjusting for potential confounding variables the rs3917406 polymorphisms was independently associated with PCAD in additive model (OR = 1.347, 95% CI = 1.12-1.62, P = 0.002) and dominant model (OR = 1.669, 95% CI = 1.26-2.21, P < 0.001). The E-selectin rs5368 polymorphisms were not associated with PCAD in univariate and multivariate analyses of three models. Conclusion: Among the Chinese Han population, the rs3917406 polymorphism of the E-selectin gene was associated with PCAD in univariate and multivariate analysis, however, no significant correlation between the E-selectin rs5368 polymorphism and PCAD.

  20. Testing of rye-specific markers located on 1RS chromosome and distribution of 1AL.RS and 1BL.RS translocations in Turkish wheat ( Triticum aestivum L., T. durum Desf.) varieties and landraces

    Microsoft Academic Search

    Fulya Eylem Yediay; Faheem Shehzad Baloch; Benjamin Kilian; Hakan Özkan

    2010-01-01

    Rye (Secale cereale L.) is a valuable source for alien chromosome translocations in wheat breeding, due to its capability to grow and sustain\\u000a under harsh environmental conditions. Wheat germplasm with 1AL.1RS and 1BL.1RS wheat-rye chromosome translocations have been\\u000a used worldwide by breeders. Determining 1AL.1RS and 1BL.1RS translocations in wheat is therefore of important practical value\\u000a for wheat improvement. In this

  1. Spectroscopy of Nine Cataclysmic Variable Stars

    NASA Astrophysics Data System (ADS)

    Sheets, Holly A.; Thorstensen, John R.; Peters, Christopher J.; Kapusta, Ann B.; Taylor, Cynthia J.

    2007-05-01

    We present optical spectroscopy of nine cataclysmic binary stars, mostly dwarf novae, obtained primarily to determine orbital periods Porb. The stars and their periods are LX And, 0.1509743(5) days; CZ Aql, 0.2005(6) days; LU Cam, 0.1499686(4) days; GZ Cnc, 0.0881(4) days; V632 Cyg, 0.06377(8) days; V1006 Cyg, 0.09903(9) days; BF Eri, 0.2708804(4) days; BI Ori, 0.1915(5) days; and FO Per, for which Porb is either 0.1467(4) or 0.1719(5) days. Several of the stars proved to be especially interesting. In BF Eri, we detect the absorption spectrum of a secondary star of spectral type K3 +/- 1 subclass, which leads to a distance estimate of ~1 kpc. However, BF Eri has a large proper motion (~100 mas yr-1), and we have a preliminary parallax measurement that confirms the large proper motion and yields only an upper limit for the parallax. BF Eri's space velocity is evidently large, and it appears to belong to the halo population. In CZ Aql, the emission lines have strong wings that move with large velocity amplitude, suggesting a magnetically channeled accretion flow. The orbital period of V1006 Cyg places it squarely within the 2 to 3 hr ``gap'' in the distribution of cataclysmic binary orbital periods. Based on observations obtained at the MDM Observatory, operated by Dartmouth College, Columbia University, Ohio State University, Ohio University, and the University of Michigan.

  2. Massive Stars

    NASA Astrophysics Data System (ADS)

    Livio, Mario; Villaver, Eva

    2009-11-01

    Participants; Preface Mario Livio and Eva Villaver; 1. High-mass star formation by gravitational collapse of massive cores M. R. Krumholz; 2. Observations of massive star formation N. A. Patel; 3. Massive star formation in the Galactic center D. F. Figer; 4. An X-ray tour of massive star-forming regions with Chandra L. K. Townsley; 5. Massive stars: feedback effects in the local universe M. S. Oey and C. J. Clarke; 6. The initial mass function in clusters B. G. Elmegreen; 7. Massive stars and star clusters in the Antennae galaxies B. C. Whitmore; 8. On the binarity of Eta Carinae T. R. Gull; 9. Parameters and winds of hot massive stars R. P. Kudritzki and M. A. Urbaneja; 10. Unraveling the Galaxy to find the first stars J. Tumlinson; 11. Optically observable zero-age main-sequence O stars N. R. Walborn; 12. Metallicity-dependent Wolf-Raynet winds P. A. Crowther; 13. Eruptive mass loss in very massive stars and Population III stars N. Smith; 14. From progenitor to afterlife R. A. Chevalier; 15. Pair-production supernovae: theory and observation E. Scannapieco; 16. Cosmic infrared background and Population III: an overview A. Kashlinsky.

  3. Predicting pKa for proteins using COSMO-RS.

    PubMed

    Andersson, Martin Peter; Jensen, Jan Halborg; Stipp, Susan Louise Svane

    2013-01-01

    We have used the COSMO-RS implicit solvation method to calculate the equilibrium constants, pKa, for deprotonation of the acidic residues of the ovomucoid inhibitor protein, OMTKY3. The root mean square error for comparison with experimental data is only 0.5 pH units and the maximum error 0.8 pH units. The results show that the accuracy of pKa prediction using COSMO-RS is as good for large biomolecules as it is for smaller inorganic and organic acids and that the method compares very well to previous pKa predictions of the OMTKY3 protein using Quantum Mechanics/Molecular Mechanics. Our approach works well for systems of about 1000 atoms or less, which makes it useful for small proteins as well as for investigating portions of larger proteins such as active sites in enzymes. PMID:24244915

  4. Narcolepsy goes to school: the three Rs for school nurses.

    PubMed

    Gow, Monica

    2014-03-01

    The sleep disorder narcolepsy most often first appears in the teen years. It can dash the dreams of optimistic, intelligent students. It can make some students the target of nasty jokes and bullying, leaving them depressed and socially isolated. It can challenge children's self-esteem, and lowered self-esteem may last a lifetime. Typically, children with narcolepsy gain weight and have no interest in participating in anything. Many constantly feel extreme tiredness, and they may experience cataplexy. School nurses and teachers can help if they know the symptoms and practice the 3 Rs of narcolepsy: Recognize the symptoms of narcolepsy; Respect that narcolepsy is a lifelong, serious sleep disorder that needs treatment; and Refer students who exhibit symptoms to medical professionals. The 3 Rs will help students living with this lifelong disorder to get a fair shake in life's academic, social, and career arenas. PMID:24707660

  5. Radiation Dry Bias of the Vaisala RS92 Humidity Sensor

    NASA Technical Reports Server (NTRS)

    Vomel, H.; Selkirk, H.; Miloshevich, L.; Valverde-Canossa, J.; Valdes, J.; Kyro, E.; Kivi, R.; Stolz, W.; Peng, G.; Diaz, J. A.

    2007-01-01

    The comparison of simultaneous humidity measurements by the Vaisala RS92 radiosonde and by the Cryogenic Frostpoint Hygrometer (CFH) launched at Alajuela, Cosla Rica, during July 2005 reveals a large solar radiation dry bias of the Vaisala RS92 humidity sensor and a minor temperature-dependent calibration error. For soundings launched at solar zenith angles between 10" and 30 , the average dry bias is on the order of 9% at the surface and increases to 50% at 15 km. A simple pressure- and temperature-dependent correction based on the comparison with the CFH can reduce this error to less than 7% at all altitudes up to 15.2 km, which is 700 m below the tropical tropopause. The correction does not depend on relative humidity, but is able to reproduce the relative humidity distribution observed by the CFH.

  6. The Nebulosity and Distance of the Cepheid RS Puppis

    E-print Network

    Michael W. Feast

    2008-04-01

    Adopting a distance for RS Pup derived from a period-luminosity relation based on Cepheid parallaxes, it is shown that the phase-lag observations of the surrounding nebulosity by Kervella et al. are well fitted by a model of an equatorial disc at an angle of 8.1 $\\pm$ 0.6 degrees to the plane of the sky. The astrophysical implications of this are briefly mentioned.

  7. Common Proper Motion Companions to Nearby Stars: Ages and Evolution

    NASA Astrophysics Data System (ADS)

    Makarov, V. V.; Zacharias, N.; Hennessy, G. S.

    2008-11-01

    A set of 41 nearby stars (closer than 25 pc) is investigated which have very wide binary and common proper motion (CPM) companions at projected separations between 1000 and 200,000 AU. These companions are identified by astrometric positions and proper motions from the NOMAD catalog. Based mainly on measures of chromospheric and X-ray activity, age estimation is obtained for most of 85 identified companions. Color-absolute magnitude diagrams are constructed to test whether CPM companions are physically related to the primary nearby stars and have the same age. Our carefully selected sample includes three remote white dwarf companions to main-sequence stars and two systems (55 Cnc and GJ 777A) of multiple planets and distant stellar companions. Ten new CPM companions, including three of extreme separations, are found. Multiple hierarchical systems are abundant; more than 25% of CPM components are spectroscopic or astrometric binaries or multiples themselves. Two new astrometric binaries are discovered among nearby CPM companions, GJ 264 and HIP 59000, and preliminary orbital solutions are presented. The Hyades kinematic group (or stream) is presented broadly in the sample, but we find few possible thick-disk objects and no halo stars. It follows from our investigation that moderately young (age<~1 Gyr) thin-disk dwarfs are the dominating species in the near CPM systems, in general agreement with the premises of the dynamical survival paradigm.

  8. The Obesity-Associated Polymorphisms FTO rs9939609 and MC4R rs17782313 and Endometrial Cancer Risk in Non-Hispanic White Women

    PubMed Central

    Lurie, Galina; Gaudet, Mia M.; Spurdle, Amanda B.; Carney, Michael E.; Wilkens, Lynne R.; Yang, Hannah P.; Weiss, Noel S.; Webb, Penelope M.; Thompson, Pamela J.; Terada, Keith; Setiawan, Veronica Wendy; Rebbeck, Timothy R.; Prescott, Jennifer; Orlow, Irene; O'Mara, Tracy; Olson, Sara H.; Narod, Steven A.; Matsuno, Rayna K.; Lissowska, Jolanta; Liang, Xiaolin; Levine, Douglas A.; Le Marchand, Loic; Kolonel, Laurence N.; Henderson, Brian E.; Garcia-Closas, Montserrat; Doherty, Jennifer Anne; De Vivo, Immaculata; Chen, Chu; Brinton, Louise A.; Akbari, Mohammad R.; Goodman, Marc T.

    2011-01-01

    Overweight and obesity are strongly associated with endometrial cancer. Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity. We examined the association of FTO rs9939609 and MC4R rs17782313 with endometrial cancer risk in a pooled analysis of nine case-control studies within the Epidemiology of Endometrial Cancer Consortium (E2C2). This analysis included 3601 non-Hispanic white women with histologically-confirmed endometrial carcinoma and 5275 frequency-matched controls. Unconditional logistic regression models were used to assess the relation of FTO rs9939609 and MC4R rs17782313 genotypes to the risk of endometrial cancer. Among control women, both the FTO rs9939609 A and MC4R rs17782313 C alleles were associated with a 16% increased risk of being overweight (p?=?0.001 and p?=?0.004, respectively). In case-control analyses, carriers of the FTO rs9939609 AA genotype were at increased risk of endometrial carcinoma compared to women with the TT genotype [odds ratio (OR) ?=?1.17; 95% confidence interval (CI): 1.03–1.32, p?=?0.01]. However, this association was no longer apparent after adjusting for body mass index (BMI), suggesting mediation of the gene-disease effect through body weight. The MC4R rs17782313 polymorphism was not related to endometrial cancer risk (per allele OR?=?0.98; 95% CI: 0.91–1.06; p?=?0.68). FTO rs9939609 is a susceptibility marker for white non-Hispanic women at higher risk of endometrial cancer. Although FTO rs9939609 alone might have limited clinical or public health significance for identifying women at high risk for endometrial cancer beyond that of excess body weight, further investigation of obesity-related genetic markers might help to identify the pathways that influence endometrial carcinogenesis. PMID:21347432

  9. Hadron star models. [neutron stars

    NASA Technical Reports Server (NTRS)

    Cohen, J. M.; Boerner, G.

    1974-01-01

    The properties of fully relativistic rotating hadron star models are discussed using models based on recently developed equations of state. All of these stable neutron star models are bound with binding energies as high as about 25%. During hadron star formation, much of this energy will be released. The consequences, resulting from the release of this energy, are examined.

  10. Coordinated ultraviolet and radio observations of selected nearby stars

    NASA Technical Reports Server (NTRS)

    Lang, Kenneth R.

    1987-01-01

    All of the US2 shifts assigned were successfully completed with simultaneous International Ultraviolet Explorer (IUE) and the Very Large Array (VLA) observations of the proposed target stars. The target stars included dwarf M flare stars and RS CVn stars. The combined ultraviolet (IUE) and microwave (VLA) observations have provided important new insights to the radiation mechanisms at these two widely-separated regions of the electromagnetic spectrum. The VLA results included the discovery of narrow-band microwave radiation and rapid time variations in the microwave radiation of dwarf M flare stars. The results indicate that conventional radiation mechanisms cannot explain the microwave emission from these stars. In general, ultraviolet variations and bursts occur when no similar variations are detected at microwave wavelengths and vice versa. Although these is some overlap, the variations in these two spectral regions are usually uncorrelated, suggesting that there is little interaction between the activity centers at the two associated atmospheric levels.

  11. FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs.

    PubMed

    Sanchis-Gomar, Fabian; Garatachea, Nuria; He, Zi-hong; Pareja-Galeano, Helios; Fuku, Noriyuki; Tian, Ye; Arai, Yasumichi; Abe, Yukiko; Murakami, Haruka; Miyachi, Motohiko; Yvert, Thomas; Santiago, Catalina; Venturini, Letizia; Fiuza-Luces, Carmen; Santos-Lozano, Alejandro; Rodríguez-Romo, Gabriel; Ricevuti, Giovanni; Hirose, Nobuyoshi; Emanuele, Enzo; Lucia, Alejandro

    2014-01-01

    Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e., being a centenarian. It has been recently shown that two single-nucleotide polymorphisms (SNPs) in the FNDC5 gene, rs16835198 and rs726344, are associated with in vivo insulin sensitivity in adults. We determined luciferase gene reporter activity in the two above-mentioned SNPs and studied genotype distributions among centenarians (n?=?175, 144 women) and healthy controls (n?=?347, 142 women) from Spain. We also studied an Italian [79 healthy centenarians (40 women) and 316 healthy controls (156 women)] and a Japanese cohort [742 centenarians (623 women) and 499 healthy controls (356 women)]. The rs726344 SNP had functional significance, as shown by differences in luciferase activity between the constructs of this SNP (all P???0.05), with the variant A-allele having higher luciferase activity compared with the G-allele (P?=?0.04). For the rs16835198 SNP, the variant T-allele tended to show higher luciferase activity compared with the G-allele (P?=?0.07). However, we found no differences between genotype/allele frequencies of the two SNPs in centenarians versus controls in any cohort, and no significant association (using logistic regression adjusted by sex) between the two SNPs and EL. Further research is needed with different cohorts as well as with additional variants in the FNDC5 gene or in other genes involved in irisin signaling. PMID:25427998

  12. Genomic characterization of ?RS603, a filamentous bacteriophage that is infectious to the phytopathogen Ralstonia solanacearum.

    PubMed

    Van, Truong Thi Bich; Yoshida, Shohei; Miki, Kaito; Kondo, Akihiro; Kamei, Kaeko

    2014-12-01

    A filamentous bacteriophage (?), ?RS603, which is infectious to the phytopathogen Ralstonia solanacearum was isolated. ?RS603 was found to have a circular single-stranded DNA genome composed of 7679 nucleotides and to contain 13 putative open reading frames (ORFs). The ?RS603 genome showed strong similarity with those of Ralstonia phages ?RSM1 and ?RSM3, as reported by Askora et al. The ?RS603 genome had no ORFs corresponding to ORFs 2, 3, 13 and 14 (integrase) of ?RSM3. ?RS603 had an ORF that was homologous to other Ralstonia phages ?RSS0 and ?RSS1; however, ?RSM1 and ?RSM3 did not. PMID:25284202

  13. Flux density and polarization observations of HIPPARCOS radio stars

    NASA Astrophysics Data System (ADS)

    Paredes, J. M.; Estalella, R.; Rius, A.

    1987-11-01

    Simultaneous flux density measurements with the 64 m antenna of the Madrid Deep Space Communication Complex (DSCC) at a wavelength of 13.1 cm and 3.6 cm, or of right and left circular polarization at 3.6 cm of a group of radio stars from the Hipparcos Input Catalogue, are reported. The total number of stars observed is 33, while the number of stars detected is 9. The polarization measurements of RS CVn systems are in agreement with a gyrosynchrotron emission mechanism. The observations of LS I +61°303 confirm the period emission at 8.4 GHz.

  14. Sea Stars

    NSDL National Science Digital Library

    2012-07-28

    At first glance, starfish, more properly called sea stars, aren’t doing much of anything. In this video, Jonathan’s investigations reveal a slow-motion predator that hunts and attacks its prey. Traveling the world, Jonathan investigates sea stars from the tropics to the Antarctic and uses time-lapse photography to reveal an amazing complexity to the world of the sea star. Please see the accompanying study guide for educational objectives and discussion points.

  15. Scintillating Stars

    NSDL National Science Digital Library

    Bob Riddle

    2003-02-01

    Often, a bright planet that is visible over the horizon will be mistaken for a star. Some believe they can tell the difference between a star and a planet because stars twinkle, or scintillate , and planets do not. In actuality however, both will twinkle because any light that passes through our atmosphere, whether it be reflected from a planet or generated by a star, will be interfered with by the atmospheric elements. This month's column sheds light on this "scintillating" subject and engages students in a research activity that revolves around the question: Is Pluto a planet?

  16. Neutron Stars

    NASA Technical Reports Server (NTRS)

    Cottam, J.

    2007-01-01

    Neutron stars were discovered almost 40 years ago, and yet many of their most fundamental properties remain mysteries. There have been many attempts to measure the mass and radius of a neutron star and thereby constrain the equation of state of the dense nuclear matter at their cores. These have been complicated by unknown parameters such as the source distance and burning fractions. A clean, straightforward way to access the neutron star parameters is with high-resolution spectroscopy. I will present the results of searches for gravitationally red-shifted absorption lines from the neutron star atmosphere using XMM-Newton and Chandra.

  17. Interaction among Caveolin-1 genotypes (rs3807987/rs7804372), H. pylori infection, and risk of gastric cancer in a Chinese population.

    PubMed

    Zhang, Ye; Hu, Xue-jun; Zhang, Lu-lu; Sun, Li-ping; Yuan, Yuan; Qu, Xiu-juan; Liu, Yun-peng

    2014-02-01

    Caveolin-1, a candidate tumor suppressor, interacts with a number of transducing molecules and plays a regulatory role in several signaling pathways. Recently, a study revealed that Cav-1 G14713A (rs3807987)/T29107A (rs7804372) polymorphisms might be associated with the susceptibility to certain cancers. In this study, we evaluated the interaction among Caveolin-1 genotypes (rs3807987/rs7804372) and Helicobacter pylori infection and increased risk of gastric cancer among the Chinese population. Blood specimens were collected from 412 gastric cancer cases to 412 noncancer controls between January 2004 and December 2012 in Liaoning Province, China. Caveolin-1 genotypes (rs3807987/rs7804372) were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Enzyme-linked immunosorbent assays were used to measure serum levels of anti-H. pylori IgG. Odds ratio and 95 % confidence interval were calculated using multivariate logistic regression adjusted by sex and age. There were significant differences between gastric cancer and control groups in the distribution of their genotypes and allelic frequencies of the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms, respectively. An elevated risk of gastric cancer was observed in patients with H. pylori infection combined with the Cav-1 G14713A, but not T29107A genotypes. The A allele of G14713A shows an interaction with H. pylori infection that increases the risk of gastric cancer. PMID:24065198

  18. Genome Sequencing of Ralstonia solanacearum Biovar 3, Phylotype I, Strains Rs-09-161 and Rs-10-244, Isolated from Eggplant and Chili in India.

    PubMed

    Ramesh, Raman; Gaitonde, Sapna; Achari, Gauri; Asolkar, Trupti; Singh, Narendra Pratap; Carrere, Sebastien; Genin, Stephane; Peeters, Nemo

    2014-01-01

    Ralstonia solanacearum Indian strains Rs-09-161 and Rs-10-244 were isolated from the coastal region of Goa and from the Andaman Islands. We report the draft genome sequences of these representative isolates infecting solanaceous vegetables in India. PMID:24874667

  19. Neuronal nitric oxide synthase (nNOS, NOS1) rs693534 and rs7977109 variants and risk for restless legs syndrome.

    PubMed

    Jiménez-Jiménez, Félix Javier; Alonso-Navarro, Hortensia; Martínez, Carmen; Zurdo, Martín; Turpín-Fenoll, Laura; Millán-Pascual, Jorge; Adeva-Bartolomé, Teresa; Cubo, Esther; Navacerrada, Francisco; Rojo-Sebastián, Ana; Rubio, Lluisa; Calleja, Marisol; Plaza-Nieto, José Francisco; Pilo-de-la-Fuente, Belén; Arroyo-Solera, Margarita; García-Albea, Esteban; García-Martín, Elena; Agúndez, José A G

    2015-06-01

    Several biochemical, neuropathological, and experimental data suggest a possible role of nitric oxide (NO) in the pathophysiology of restless legs syndrome (RLS). Two single nucleotide polymorphisms (SNPs) neuronal nitric oxide synthase (nNOS or NOS1) gene (rs7977109 and rs693534) have been found to be associated with the risk for RLS in Germans, although only one of them (rs7977109) remained as significant after multiple comparison tests. The aim of our study was to replicate the possible association between these SNPs and risk for RLS in the Spanish population. We studied the allelic and genotype frequencies of the SNPs rs7977109 and rs693534 in 205 patients with RLS and 328 healthy controls using TaqMan genotyping. The rs7977109 and rs693534 genotypes and allelic frequencies did not significantly differ between patients with RLS and controls and were unrelated with the age at onset of RLS, gender, ferritin levels, and response to dopaminergic or gabaergic agents. The rs7999109GA genotype was overrepresented in RLS patients with positive family history of RLS, and in patients with symptomatic response to clonazepam. The results of our study suggest that these two NOS1 SNPs are not related to the overall risk for RLS in the Spanish population. PMID:25300364

  20. High-Resolution N-Band Observations of the Nova RS Ophiuchi with the Keck Interferometer Nuller

    NASA Technical Reports Server (NTRS)

    Barry, R. K.; Danchi, W. C.; Sokoloski, J. L.; Koresko, C.; Wisniewski, J. P.; Serabyn, E.; Traub, W.; Kuchner, M.; Greenhouse, M. A.

    2007-01-01

    We report new observations of the nova RS Ophiuchi (RS Oph) using the Keck Interferometer Nulling Instrument, approximately 3.8 days following the most recent outburst that occurred on 2006 February 12. The Keck Interferometer Nuller (KIN) operates in K-band from 8 to 12.5 pm in a nulling mode, which means that the central broad-band interference fringe is a dark fringe - with an angular width of 25 mas at mid band - rather than the bright fringe used ill a conventional optical interferometer. In this mode the stellar light itself is suppressed by the destructive fringe, effectively enhancing the contrast of the circumstellar material located near the star. By subsequently shifting the neighboring bright fringe onto the center of the source brightness distribution and integrating, a second spatial regime dominated by light from the central portion of the source is almost simultaneously sampled. The nulling technique is the sparse aperture equivalent of the conventional corongraphic technique used in filled aperture telescopes. By fitting the unique KIK inner and outer spatial regime data, we have obtained an angular size of the mid-infrared continuum of 6.2, 4.0. or 5.4 mas for a disk profile, gaussian profile (fwhm), and shell profile respectively. The data show evidence of enhanced neutral atomic hydrogen emission located in the inner spatial regime relative to the outer regime. There is also evidence of a 9.7 micron silicate feature seen outside of this region. Importantly, we see spectral lines excited by the nova flash in the outer region before the blast wave reaches these regions. These lines are from neutral, weakly excited atoms which support the following interpretation. We discuss the present results in terms of a unifying model of the system that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star. These data show the power and potential of the nulling technique which has been developed for the detection of Earth-like planets around nearby stars for the Terrestrial Planet Finder Mission and Darwin missions.

  1. Swift Observations of Shock Evolution in RS Ophiuchi

    E-print Network

    Bode, M F; Page, K L; Beardmore, A P; O'Brien, T J; Ness, J -U; Starrfield, S; Skinner, G K; Darnley, M J; Drake, J J; Evans, A; Eyres, S P S; Krautter, J; Schwarz, G

    2008-01-01

    Our \\textit{Swift} observations of RS Oph form an unprecedented X-ray dataset to undertake investigations of both the central source and the interaction of the outburst ejecta with the circumstellar environment. Over the first month, the XRT data are dominated by emission from rapidly evolving shocks. We discuss the differences in derived parameters from those found for \\textit{RXTE} at early times and the evolution of the X-ray emission to much later times. It is apparent that at late times several emission components are present. We find no strong evidence of the proposed shock break-out in our data.

  2. rs11671784 G/A and rs895819 A/G Polymorphisms Inversely Affect Gastric Cancer Susceptibility and miR-27a Expression in a Chinese Population

    PubMed Central

    Song, Bo; Yan, Ge; Hao, Hankun; Yang, Bei

    2014-01-01

    Background rs895819 and rs11671784 are 2 SNPs in miR-27a that can influence the expression of mature miRNA. However, their role in gastric cancer development is still not well understood. This study aimed to determine whether these 2 polymorphisms are associated with gastric cancer risk in a Chinese population and how they influence the expression of miR-27a. Material/Methods This was a case-control study and recruited 278 gastric cases and 278 healthy matched controls. Genotyping of these 2 SNPs among the participants were performed to assess their association with gastric cancer risk. Tumor samples from 59 patients who had physical resection were used for qRT-PCR analysis of miR-27a expression. To further valid the effects of these 2 SNPs, findings of previous studies were pooled to generate integrated evidence. Results Individuals with rs895819 G variants exhibited significantly increased risk of gastric cancer, while subjects with rs11671784 A variants had significantly reduced gastric cancer risk. Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene. The subsequent meta-analysis largely confirmed the effects of these 2 SNPs on gastric cancer risk. Conclusions rs895819 and rs11671784 inversely affect gastric cancer risk and the influence was closely related to their effects on miR-27a expression. PMID:25399405

  3. STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C Polymorphisms Influence the Risk of Developing Juvenile Idiopathic Arthritis in Han Chinese Patients

    PubMed Central

    Fan, Zhi-Dan; Wang, Fei-Fei; Huang, Hui; Huang, Na; Ma, Hui-Hui; Guo, Yi-Hong; Zhang, Ya-Yuan; Qian, Xiao-Qing; Yu, Hai-Guo

    2015-01-01

    Juvenile idiopathic arthritis (JIA) is a common autoimmune disease characterized by environmental influences along with several predisposing genes in the pathogenesis. The protein tyrosine phosphatase nonreceptor 22 (PTPN22) and signal transducer and activator of transcription factor 4 (STAT4) have been recognized as susceptibility genes for numerous autoimmune diseases. Associations of STAT4 rs7574865 G/T and PTPN22 (rs2488457 G/C and rs2476601 C/T) polymorphisms with JIA have repeatedly been replicated in several Caucasian populations. The aim of this study was to investigate the influence of three polymorphisms mentioned above on the risk of developing JIA in Han Chinese patients. Genotyping was performed on a total of 137 Chinese patients with JIA (JIA group) and 150 sex and age frequency-matched healthy volunteers (Control group). The single-nucleotide polymorphisms (SNP) were determined by using direct sequencing of PCR-amplified products. There were significant differences of PTPN22 rs2488457 G/C and STAT4 rs7574865 G/T polymorphisms between both groups. However, no significant difference was observed in distribution frequencies of PTPN22 rs2476601 polymorphism. The association with the PTPN22 rs2488457 G/C polymorphism remained significant in the stratifications by age at onset, ANA status, splenomegaly, lymphadenectasis and involvement joints. As with the STAT4 rs7574865 G/T polymorphisms, the enthesitis-related arthritis and presence of hepatomegaly had strong effect on the association. Our data strengthen STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms as susceptibility factors for JIA. PMID:25781893

  4. LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography

    PubMed Central

    2014-01-01

    Background Polymorphisms in the LPA gene were associated with coronary artery disease (CAD). However, there are differences in the allelic frequencies, Lp(a) levels, and significant association with CAD according to ethnic groups. In this scenario, the main aim of this study was to assess the influence of the LPA polymorphisms on coronary lesions in Brazilian patients. Methods 1,394 consecutive patients submitted to coronary angiography to study suggestive CAD and twenty coronary segments were scored. Genotyping for the LPA rs10455872 and rs3798220 polymorphisms were performed by high resolution melting analysis. Results The frequencies of the rs10455872 G and rs3798220 C variant alleles were 6.4% and 6.2%, respectively. LPA rs10455872 G variant allele was associated with higher odds ratio of having coronary lesions in an adjusted model (OR?=?2.02, 95% CI?=?1.10-3.72, p?=?0.02). Scores of coronary lesions (extension, severity, and Gensini scores) were significantly different among rs10455872 genotype groups. Coronary lesions was not associated with LPA rs3798220 (OR?=?1.09, 95% CI?=?0.67-1.76, p?=?0.73) and scores of coronary lesions were not different among rs3798220 genotypes. Conclusions We confirmed the association of the LPA rs10455872 with CAD in a large sample of Brazilian patients. For the LPA rs3798220, our finding is consistent with studies which showed the lack of this genetic association. PMID:24776095

  5. First science with the Keck Interferometer Nuller: high spatial resolution N-band observations of the recurrent nova RS Ophiuchi

    NASA Astrophysics Data System (ADS)

    Barry, R. K.; Danchi, W. C.; Traub, W.; Kuchner, M.; Wisniewski, J. P.; Akeson, R.; Colavita, M.; Greenhouse, M. A.; Koresko, C.; Mennesson, B.; Serabyn, E.; Sokoloski, J. L.

    2008-07-01

    We report observations of the nova RS Ophiuchi using the Keck Interferometer Nuller (KIN) taken approximately 3.8 days following the most recent outburst that occurred on 2006 February 12. The KIN operates in N-band from 8 to 12.5 ?m in a nulling mode. In this mode the stellar light is suppressed by a destructive fringe, effectively enhancing the contrast of the circumstellar material located near the star. In a second, constructive-fringe mode, the instrument detects primarily the light from the central, bright source. These are the outer and inner spatial regimes, respectively. We will describe the capabilities of the KIN, including these unique modes, and outline how they were key in our discovery that dust was created between nova events. We also show how these first results from the KIN are consistent with Spitzer data. The KIN data show evidence of enhanced neutral atomic hydrogen emission and atomic metals including silicon located in the inner spatial regime (< 4 AU from theWD) relative to the outer regime. There are also nebular emission lines and evidence of hot silicate dust in the outer spatial region, centered at approximately ~ 17 AU from the WD, that are not found in the inner regime. The KIN and Spitzer data suggest that these emissions were excited in the outer spatial regime before the blast wave reached these regions. We describe the present results in terms of a new model for dust creation in recurrent novae that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star. These data show the power and potential of the nulling technique which has been developed for the detection of Earth-like planets around nearby stars for the Terrestrial Planet Finder Mission and Darwin missions.

  6. Creative implementation of 3Rs principles within industry programs: beyond regulations and guidelines.

    PubMed

    Bratcher, Natalie A; Reinhard, Gregory R

    2015-03-01

    The industry involved with using animals as an essential part of research has supported the theory and philosophy of the 3Rs for years. However, both the culture and approach surrounding the 3Rs is evolving rapidly, and many institutions are attempting to surpass the regulations and guidelines to implement the 3Rs for improved science and animal welfare. Regulatory documents and guidelines such as the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, the Public Health Service Policy on Humane Care and Use of Laboratory Animals, and the US Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training clearly outline how the IACUC should address the 3Rs, but there are many additional paradigms and resources that an institution can use to promote the 3Rs creatively. We review the legal mandates and guidelines that institutions must or should follow, and we present some creative approaches toward their compliance, including the creation of full-time dedicated 3Rs roles as well as temporary 3Rs-focused positions such as visiting scientist and postdoctoral fellowships and internships. We also discuss how to creatively achieve 3Rs progress through internal committees and working groups, involvement in 3Rs consortia, recognizing 3Rs advances through awards programs, and creating 3Rs volunteer opportunities. Adherence to regulations and guidelines creates a solid foundation for good animal care and science, and creative 3Rs approaches enable the growth of a robust animal welfare culture that enhances the potential for 3Rs benefits to animals and science. PMID:25836958

  7. Radio stars.

    PubMed

    Hjellming, R M; Wade, C M

    1971-09-17

    Up to the present time six classes of radio stars have been established. The signals are almost always very faint and drastically variable. Hence their discovery has owed as much to serendipity as to the highly sophisticated equipment and techniques that have been used. When the variations are regular, as with the pulsars, this characteristic can be exploited very successfully in the search for new objects as well as in the detailed study of those that are already known. The detection of the most erratically variable radio stars, the flare stars and the x-ray stars, is primarily a matter of luck and patience. In the case of the novas, one at least knows where and oughly when to look for radio emission. A very sensitive interferometer is clearly the best instrument to use in the initial detection of a radio star. The fact that weak background sources are frequently present makes it essential to prove that the position of a radio source agrees with that of a star to within a few arc seconds. The potential of radio astronomy for the study of radio stars will not be realized until more powerful instruments than those that are available today can be utilized. So far, we have been able to see only the most luminous of the radio stars. PMID:17836594

  8. Star Journey

    NSDL National Science Digital Library

    Carolyn Anderson

    This National Geographic web-site contains information about the Hubble Space Telescope (HST) along with a star chart and facts about objects in the night sky. The HST section contains details about the building and structure of the HST, how it captures light, positioning the HST to targets, instruments used to record and measure infrared through UV wavelengths, how the HST is powered and communicates with the Earth. Star Attractions discusses properties of constellations, the Milky Way galaxy, other galaxies, star clusters and nebulae. This information is then put together on the National Geographic Star Chart. This chart contains maps of the heavens for the northern and southern hemispheres. The chart contains constellation names, location of stars and other objects, and links to HST images of various galaxies and objects on the chart with names and detailed descriptions. There is an image index to find HST images from the site, details about chart symbol meanings, and links for more information.

  9. Star dust.

    PubMed

    Ney, E P

    1977-02-11

    Infrared astronomy has shown that certain classes of stars are abundant producers of refractory grains, which condense in their atmospheres and are blown into interstellar space by the radiation pressure of these stars. Metallic silicates of the kind that produce terrestrial planets are injected by the oxygen-rich stars and carbon and its refractories by carbon stars. Much of the interstellar dust may be produced by this mechanism. A number of "infrared stars" are completely surrounded by their own dust, and a few of these exhibit a unique morphology that suggests the formation of a planetary system or a stage in the evolution of a planetary nebula. Certain novae also condense grains, which are blown out in their shells. In our own solar system, comets are found to contain the same silicates that are present elsewhere in the galaxy, suggesting that these constituents were present in the primeval solar nebula. PMID:17732279

  10. Information extraction of typical karst landform based on RS

    NASA Astrophysics Data System (ADS)

    Huang, Shufen; Lan, Anjun; Ma, Jiaqiong; Guo, Haixiang

    2014-05-01

    Guizhou Province is the most typical karst landform area of Southwest China Karst, and how to exactly extract the typical karst landform information is important to the economic development of Guizhou. Not any method based on Remote Sensing (Hereinafter referred to as RS) to extract the karst landform were reported or published. For obtaining the accuracy information of karst landform, 10 meters resolution ALOS image is used to extract the karst landform information in Guanling County of Guizhou Province in this paper. The multiscale segmentations of RS images were finished and typical of karst landform in case study area were classified with the different segmentation rules created on the eCognition Developer platform. For mostly improving the accuracy of extraction information, the experiment areas are focused on the fengcong depressions, fengcong valleys, and fenglin basins. The results show that the fengcong depressions, fengcong valleys, and fenglin basins can be respectively well extracted from the images when the segmentation scale are respectively 280, 480 and 200, shape parameter is 0.8, and tightness parameter is 0.5. We believed the research would provide an important reference to extract the karst landform information in whole Guizhou, China or global level.

  11. IFITM3 Polymorphism rs12252-C Restricts Influenza A Viruses

    PubMed Central

    Grotefend, Christopher Robert; Radic, Vladimir; Chung, Changik; Chung, Young-Hwa; Farzan, Michael; Huang, I-Chueh

    2014-01-01

    The IFITM3 polymorphism rs12252-C, which encodes an IFITM3 isoform (?21 IFITM3) lacking 21 amino acids at the amino terminus, has been controversially associated with poor clinical outcomes in patients with H1N1 influenza A virus (IAV) infections. In vitro studies have shown that ?21 IFITM3 loses its ability to restrict H1N1 IAV. Subsequent research has also revealed that tyrosine 20 is the key determinant for IFITM3 endocytic trafficking, which is essential for the efficient anti-viral activity of IFITM3. In contrast to previous studies, we demonstrated that both ?21 IFITM3 and an IFITM3 variant (Y20A IFITM3), in which tyrosine 20 is substituted with alanine, strongly restricted entry mediated by IAV H1, H3, H5, and H7 proteins. ?21 IFITM3 also efficiently suppressed replication of H1N1 and, to a lesser extent, H3N2 IAV. ?21 IFITM3 and Y20A IFITM3 had broader subcellular distributions than full-length IFITM3 but an abundant amount of both IFITM3 variants still localized to late endosomes and lysosomes. Our data indicate that tyrosine 20 partially regulates the subcellular localization of IFITM3 but is not functionally essential for IFITM3-mediated IAV restriction. They also suggested that mechanisms, other than viral entry restriction, might contribute to variations in clinical outcomes of H1N1 influenza associated with rs12252-C. PMID:25314048

  12. Einstein Observatory coronal temperatures of late-type stars

    NASA Technical Reports Server (NTRS)

    Schmitt, J. H. M. M.; Collura, A.; Sciortino, S.; Vaiana, G. S.; Harnden, F. R., Jr.

    1990-01-01

    The results are presented of a survey of the coronal temperatures of late-type stars using the Einstein Observatory IPC. The spectral analysis shows that the frequently found one- and two-temperature descriptions are mainly influenced by the SNR of the data and that models using continuous emission measure distributions can provide equally adequate and physically more meaningful and more plausible descriptions. Intrinsic differences in differential emission measure distributions are found for four groups of stars. M dwarfs generally show evidence for high-temperature gas in conjunction with lower-temperature material, while main-sequence stars of types F and G have the high-temperature component either absent or very weak. Very hot coronae without the lower-temperature component appearing in dwarf stars are evident in most of the giant stars studied. RS CVn systems show evidence for extremely hot coronae, sometimes with no accompanying lower-temperature material.

  13. The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS

    PubMed Central

    Fernández, Lucía; Jenssen, Håvard; Bains, Manjeet; Wiegand, Irith; Gooderham, W. James

    2012-01-01

    Cationic antimicrobial peptides pass across the outer membrane by interacting with negatively charged lipopolysaccharide (LPS), leading to outer membrane permeabilization in a process termed self-promoted uptake. Resistance can be mediated by the addition of positively charged arabinosamine through the action of the arnBCADTEF operon. We recently described a series of two-component regulators that lead to the activation of the arn operon after recognizing environmental signals, including low-Mg2+ (PhoPQ, PmrAB) or cationic (ParRS) peptides. However, some peptides did not activate the arn operon through ParRS. Here, we report the identification of a new two-component system, CprRS, which, upon exposure to a wide range of antimicrobial peptides, triggered the expression of the LPS modification operon. Thus, mutations in the cprRS operon blocked the induction of the arn operon in response to several antimicrobial peptides independently of ParRS but did not affect the response to low Mg2+. Distinct patterns of arn induction were identified. Thus, the responses to polymyxins were abrogated by either parR or cprR mutations, while responses to other peptides, including indolicidin, showed differential dependency on the CprRS and ParRS systems in a concentration-dependent manner. It was further demonstrated that, following exposure to inducing antimicrobial peptides, cprRS mutants did not become adaptively resistant to polymyxins as was observed for wild-type cells. Our microarray studies demonstrated that the CprRS system controlled a quite modest regulon, indicating that it was quite specific to adaptive peptide resistance. These findings provide greater insight into the complex regulation of LPS modification in Pseudomonas aeruginosa, which involves the participation of at least 4 two-component systems. PMID:23006746

  14. MPI-LAPI: An Efficient Implementation of MPI for IBM RS\\/6000 SP Systems

    Microsoft Academic Search

    Mohammad Banikazemi; Rama K. Govindaraju; Robert Blackmore; Dhabaleswar K. Panda

    2001-01-01

    The IBM RS\\/6000 SP system is one of the most cost-effective commercially available highperformance machines. IBM RS\\/6000 SP systems support the Message Passing Interfacestandard (MPI) and LAPI. LAPI is a low level, reliable and efficient one sided communicationAPI library, implemented on IBM RS\\/6000 SP systems. This paper explains howthe high performance of the LAPI library has been exploited in order

  15. Association of the three common SNPs of cyclooxygenase-2 gene (rs20417, rs689466, and rs5275) with the susceptibility of breast cancer: an updated meta-analysis involving 34,590 subjects.

    PubMed

    Dai, Zhi-Jun; Shao, Yong-Ping; Ma, Xiao-Bin; Xu, Dan; Tang, Wei; Kang, Hua-Feng; Lin, Shuai; Wang, Meng; Ren, Hong-Tao; Wang, Xi-Jing

    2014-01-01

    Several single nucleotide polymorphisms have been identified in cyclooxygenase-2 (COX-2) genes (e.g., -765 G>C (rs20417), -1195G>A (rs689466), and 8473 C>T (rs5275)). The association of these SNPs with the risk of different cancer types is still controversial. This study aims to evaluate the correlation between these SNPs and breast cancer risk in different ethnic groups. We have searched PubMed, Web of Knowledge, and Embase for relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the associations. A total of 13 studies (15,330 cases and 19,260 controls) were eligible for meta-analysis. This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians. The rs5275 polymorphism had no association with breast cancer risk. PMID:25214704

  16. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo.

    PubMed Central

    Eglen, R. M.; Bonhaus, D. W.; Johnson, L. G.; Leung, E.; Clark, R. D.

    1995-01-01

    1. The pharmacology of two novel 5-HT4 receptor agonists, RS 67333 (1-(4-amino-5-chloro-2-methoxy-phenyl)-3-[1(n-butyl)-4-piperidinyl]-1- propanone HCl) and RS 67506 (1-(4-amino-5-chloro-2-methoxy-phenyl)-3-[1-(2-methyl sulphonylamino)ethyl-4-piperidinyl]-1-propanone HCl) have been assessed in vitro and in vivo. 2. RS 67333 and RS 67506 exhibited affinities (pKi = 8.7 and 8.8, respectively) for the 5-HT4 binding sites, labelled with [3H]-GR 113808, in guinea-pig striatum. The Hill coefficients from these displacement curves were not significantly different from unity. The compounds exhibited lower affinities (< 6.0) at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. However, RS 67333 and RS 67506 did exhibit affinities for the sigma 1 (pKi = 8.9 and 7.9, respectively) and sigma 2 (pKi = 8.0 and 7.3, respectively) binding sites. 3. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 and RS 67506 acted as potent (pEC50 8.4 and 8.6, respectively), partial agonists (intrinsic activities, with respect to 5-HT were 0.5 and 0.6, respectively) with respect to 5-HT. Relaxant responses to RS 67333 or RS 67506 were surmountably antagonized by GR 11308 (10 nM), with apparent affinities (pKB) of 9.1 and 9.0, respectively. RS 67333 and RS 67506 induced dose-dependent increases in heart rate of the anaesthetized micropig (ED50 4.9 and 5.4 micrograms kg-1, i.v.), with maximal increases of 35 and 47 beats min-1, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8564196

  17. Texas A&M University GIS/RS certificate application. Revised 07/2014

    E-print Network

    Semester/year taken Credits Grade Introductory level (one is required) ______ ESSM 655 ____________________ _______ _______ ______ GEOG 661 ____________________ _______ _______ Specialized RS courses (one is required) ______ ATMO 655

  18. Complete genome sequence of a filamentous bacteriophage, RS611, that infects the phytopathogen Ralstonia solanacearum.

    PubMed

    Van, Truong Thi Bich; Yoshida, Shohei; Miki, Kaito; Kondo, Akihiro; Kamei, Kaeko

    2015-03-01

    Filamentous bacteriophage RS611 (?RS611), which infects the phytopathogen Ralstonia solanacearum, had a circular single-stranded DNA genome that was characterized as an Ff-type phage belonging to the family Inoviridae. The ?RS611 genome was composed of 6386 bases with a G + C content of 62.1 % and contained 11 putative open reading frames. The ?RS611 genome showed high similarity to those of Ralstonia phages RSS0 and RSS1. However, approximately 900-nucleotide deletions were found in the region corresponding to open reading frames 10 and 11 of ?RSS0 and ?RSS1. PMID:25559667

  19. Stars equilibrium

    NSDL National Science Digital Library

    University of Utah. Astrophysics Science Project Integrating Research and Education (ASPIRE)

    2003-01-01

    What causes the fusion reaction in a star's core? This activity page, part of an interactive laboratory series for grades 8-12, introduces students to processes inside a star. Students read about the equilibrium process in a star, in which outward gas pressure equals inward gravitational pressure. Then, an interactive lab activity offers students the opportunity to predict temperature, pressure, and gravity changes that occur during equilibrium. The chemical reactions of the fusion process are presented, and more specific detailed reactions are available in a pop-up box. Student practice quizzes about the equilibrium process and pressure and gravity interactions inside the star are included, as are answers. Copyright 2005 Eisenhower National Clearinghouse

  20. Neutron stars

    NASA Astrophysics Data System (ADS)

    Lattimer, James M.

    2014-05-01

    Neutron stars are laboratories for dense matter and gravitational physics. Observations of neutron stars from sources such as radio pulsars, low-mass X-ray binaries, X-ray bursts and thermally-emitting neutron stars are setting bounds to neutron star masses, radii, rotation rates, temperatures and ages. Mass measurements constrain the equation of state at the highest densities and set firm bounds to the highest possible density of cold matter. Radii constrain the equation of state in the vicinity of the nuclear saturation density and yield information about the density dependence of the nuclear symmetry energy. Laboratory measurements and theoretical studies of pure neutron matter are in remarkable agreement with observational bounds.

  1. Flaring on RS CVn systems: Results from EUVE Photometry

    NASA Astrophysics Data System (ADS)

    Osten, R. A.; Brown, A.; Ayres, T. R.

    We present broadband EUV photometry for a sample of RS CVn systems observed with the Deep Survey Spectrometer and Right Angle Program (RAP) Scanners on the Extreme Ultraviolet Explorer (EUVE). We have developed robust data analysis and light curve software for the interpretation of these data. Large-scale flaring activity is seen on 15 of the 18 systems studied. These binaries cover a range in orbital period of 0.7 days to 21 days and include a mixture of giant, subgiant, and dwarf luminosity classes. For many systems the photometric coverage extends over several orbital periods and flaring is unambiguously characterized. We present statistics on the distribution of variability in the survey. Correlations of flaring with binary properties are examined.

  2. RS-A4 relaxation of flavor and CP violation

    NASA Astrophysics Data System (ADS)

    Kadosh, Avihay

    2013-03-01

    I discuss a model based on an A4 bulk flavor symmetry in the Randall-Sundrum (RS) setup. After discussing the setup and leading order results for the masses and mixings of quarks and leptons, I elaborate on the effect of higher order "cross-talk" corrections, their contributions to flavor violating processes and the resulting constraints on the model parameter space and the Kaluza-Klein (KK) mass scale. In addition, I present a systematic study of higher order corrections to the PMNS matrix in light of the recent measurements of ? 13 > 0 by RENO and Daya Bay. Finally, I also comment on the model new physics contributions to B_{s,d}to?+?^- and ? ? e?, in light of the new upper bounds recently set by the LHCb and MEG experiment.

  3. Preparation and characterization of nebivolol nanoparticles using Eudragit® RS100.

    PubMed

    Jana, Utpal; Mohanty, Anjan Kumar; Manna, Prabal Kumar; Mohanta, Guru Prasad

    2014-01-01

    Nebivolol, a beta-blocker, has been widely used for the treatment of hypertension and cardiovascular diseases; but has drawbacks like poor solubility and bioavailability requiring frequent dosing. The present study attempts to overcome these issues through nanoparticulate delivery system using widely used carrier Eudragit(®) RS100. The solvent evaporation (single emulsion) technique was used for developing nanoparticles. The impact of formulation and process variables on particle size and entrapment efficiency was studied to optimize the formulation. The physico-chemical characterization confirmed the particle size in nano range with smooth and spherical morphology. Further, Fourier transforms infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) studies confirm compatibility of drug-polymer combination. The in vitro drug release study of the prepared nanoparticles showed prolongation of drug release with reduced burst release in comparison with pure drug powder. PMID:24140793

  4. Smoke plume impacts on photolysis frequencies during SEAC4RS

    NASA Astrophysics Data System (ADS)

    Hall, S. R.; Ullmann, K.; Madronich, S.; Hair, J. W.; Fenn, M. A.; Butler, C. F.; Anderson, B. E.; Ziemba, L. D.; Beyersdorf, A. J.

    2014-12-01

    The Studies of Emissions and Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys (SEAC4RS) campaign during the summer of 2013 was strongly impacted by smoke from fires in the western United States. Scattering and absorption by particles in the plume directly impact actinic flux spectra which drives the photochemistry. Near the fire, high absorption results in low photolysis rates. In combination with strong plume convection (including pyro-convection), this permits injection of volatile, normally short-lived species to the free troposphere and beyond. Measurements from the Charged-coupled device Actinic Flux Spectroradiometers (CAFS) onboard the NASA DC-8 aircraft show penetration of the California Rim fire reduced in situ ozone photolysis by as much as 95% and nitrogen dioxide photolysis by 80%. Downstream, the aged plume can contain high concentrations of strongly scattering particles attributed to hygroscopic growth. Evidence will be sought for enhancement of photolysis above such plumes by comparison with a radiative transfer model.

  5. Milli-Arcsecond Infrared Observations of the Nova RS Ophiuchi

    NASA Technical Reports Server (NTRS)

    Barry, Richard K.; Danchi, W. C.; Koresko, C.; Kuchner, M.; Traub, W. A.; Monnier, J. D.; Serabyn, E.; Mennesson, B.; Greenhouse, M. A.; Colavita, M. M.; Lane, B. F.

    2007-01-01

    We report on infrared interferometric measurements of the 2006 outburst of Nova RS Oph in H, K, and N bands. These measurements, conducted using the Infrared and Optical Telescope Array, the Palomar Testbed Interferometer, and the Keck Interferometer, show a small variation in the 3 mas size if this resolved source during the first 65 days of the outburst. Additionally, using interferometric closure phases, these observations show an unambiguous departure from point symmetry of the object. We also describe simultaneous N-band observations of the nova in two separate milli-arcsecond spatial regimes on day four in which we detect line emission indicating onset of the optically thin phase. These data represent the first science from the Keck Interferometer's nulling mode.

  6. Black Holes and Wormholes in RS2 Type Brane Worlds

    NASA Astrophysics Data System (ADS)

    Bronnikov, K. A.; Michtchenko, A. V.

    We review some recent results concerning the properties of static, spherically symmetric configurations in RS2 type brane worlds: 1) Solving the trace of the effective 4D gravity equations, we obtain general classes of black hole and wormhole metrics, including families which unify symmetric wormholes, extremal black holes and non-extremal non-singular black holes. 2) Assuming E? ? = 0 (where E? ? is a part of the 5D Weyl tensor contributing to the 4D gravity equations), we show that material scalar fields confined on the brane may violate the no-hair theorem, support wormholes or form particlelike objects, but only at super-nuclear matter densities in the strong field region. 3) Solutions to the bulk field equations are found in case E? ? ? 0, among them solutions with a nonzero 4D cosmological constant, generalizing the so-called "black string".

  7. Tycho's Star

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    A supernova remnant in Cassiopeia, 7.7° north of ? Cas, which suddenly appeared as a brilliant naked-eye star in November 1572 and reached a maximum apparent magnitude of -3.5. Until its disappearance 16 months later, it was extensively studied by the Danish astronomer Tycho Brahe (1546-1601), who described its early appearance as follows: `Initially, the new star was brighter than any other fixe...

  8. Tycho's Star

    Microsoft Academic Search

    P. Murdin

    2000-01-01

    A supernova remnant in Cassiopeia, 7.7° north of alpha Cas, which suddenly appeared as a brilliant naked-eye star in November 1572 and reached a maximum apparent magnitude of -3.5. Until its disappearance 16 months later, it was extensively studied by the Danish astronomer Tycho Brahe (1546-1601), who described its early appearance as follows: `Initially, the new star was brighter than

  9. High-Resolution N-Band Observations of the Nova Rs Ophiuchi: First Science with the Keck Interferometer Nuller

    NASA Technical Reports Server (NTRS)

    Danchi, William

    2008-01-01

    We report new observations of the nova RS Ophiuchi using the Keck Interferometer Nulling Instrument (KIN), approximately 3.8 days following the most recent outburst that occurred on 2006 February 12. These observations represent the first scientific results from the KIN, which operates in N-band from 8 to 12.5 microns. The nulling technique is the sparse aperture equivalent of the conventional coronagraphic technique used in filled aperture telescopes. By fitting the unique KIN inner and outer spatial regime data, we have obtained an angular size of the mid-infrared continuum of 6.2,4.0, or 5.4 mas for a disk profile, Gaussian profile, and shell profile respectively. The data show evidence of enhanced neutral atomic hydrogen emission and atomic metals including silicon located in the inner spatial regime near the white dwarf relative to the outer regime. There are also nebular emission lines and evidence of hot silicate dust in the outer spatial region, centered at approximately 2.5E14 cm from the WD, that are not found in the inner regime. The nova flash in the outer spatial regime evidently excited these features before the blast wave reached these regions. These identifications support the following interpretation. The dust appears to be present between outbursts and was not created during the outburst event. We further discuss the present results in terms of a unifying model of the system that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star. These data show the power and potential of the nulling technique which has been developed for the detection of Earthlike planets around nearby stars for the Terrestrial Planet Finder Mission and Darwin missions.

  10. High-resolution N-band Observations Of The Nova Rs Ophiuchi: First Science With The Keck Interferometer Nuller

    NASA Astrophysics Data System (ADS)

    Barry, Richard K.; Danchi, W. C.; Sokoloski, J. L.; Koresko, C.; Wisniewski, J.; Serabyn, E.; Traub, W.; Kuchner, M.; Greenhouse, M.

    2007-12-01

    We report new observations of the nova RS Ophiuchi using the Keck Interferometer Nulling Instrument (KIN), approximately 3.8 days following the most recent outburst that occurred on 2006 February 12. These observations represent the first scientific results from the KIN, which operates in N-band from 8 to 12.5 microns. The nulling technique is the sparse aperture equivalent of the conventional coronagraphic technique used in filled aperture telescopes. By fitting the unique KIN inner and outer spatial regime data, we have obtained an angular size of the mid-infrared continuum of 6.2, 4.0, or 5.4 mas for a disk profile, Gaussian profile, and shell profile respectively. The data show evidence of enhanced neutral atomic hydrogen emission and atomic metals including silicon located in the inner spatial regime near the white dwarf relative to the outer regime. There are also nebular emission lines and evidence of hot silicate dust in the outer spatial region, centered at approximately 2.5E14 cm from the WD, that are not found in the inner regime. The nova flash in the outer spatial regime evidently excited these features before the blast wave reached these regions. These identifications support the following interpretation. The dust appears to be present between outbursts and was not created during the outburst event. We further discuss the present results in terms of a unifying model of the system that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star. These data show the power and potential of the nulling technique which has been developed for the detection of Earth-like planets around nearby stars for the Terrestrial Planet Finder Mission and Darwin missions.

  11. Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis.

    PubMed

    Naderi, Mohammad; Hashemi, Mohammad; Khorgami, Parisa; Koshki, Maliheh; Ebrahimi, Mahboubeh; Amininia, Shadi; Sharifi-Mood, Batool; Taheri, Mohsen

    2015-01-01

    Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings. PMID:25815281

  12. Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis

    PubMed Central

    Naderi, Mohammad; Hashemi, Mohammad; Khorgami, Parisa; Koshki, Maliheh; Ebrahimi, Mahboubeh; Amininia, Shadi; Sharifi-Mood, Batool; Taheri, Mohsen

    2015-01-01

    Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings. PMID:25815281

  13. STAR FORMATION HISTORIES IN A CLUSTER ENVIRONMENT AT z {approx} 0.84

    SciTech Connect

    Demarco, R. [Department of Astronomy, Universidad de Concepcion, Casilla 160-C, Concepcion (Chile); Gobat, R. [CEA, Laboratoire AIM, Irfu/SAp, F-91191 Gif-sur-Yvette (France); Rosati, P. [European Southern Observatory, Karl-Schwarzschild-Strasse 2, D-85748 Garching (Germany); Lidman, C. [Anglo-Australian Observatory, P.O. Box 296, Epping, NSW 1710 (Australia); Rettura, A. [Department of Physics and Astronomy, University of California, Riverside, 900 University Avenue, Riverside, CA 92521 (United States); Nonino, M. [INAF-OAT, via G. B. Tiepolo 11, 40131 Trieste (Italy); Van der Wel, A. [Max-Planck Institute for Astronomy, Koenigstuhl 17, D-69117, Heidelberg (Germany); Jee, M. J. [Department of Physics, University of California, Davis, One Shields Avenue, Davis, CA 95616 (United States); Blakeslee, J. P. [Herzberg Institute of Astrophysics, National Research Council of Canada, Victoria, BC V9E 2E7 (Canada); Ford, H. C. [Department of Physics and Astronomy, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Postman, M., E-mail: rdemarco@astro-udec.c [Space Telescope Science Institute, Baltimore, MD 21218 (United States)

    2010-12-10

    We present a spectrophotometric analysis of galaxies belonging to the dynamically young, massive cluster RX J0152.7-1357 at z {approx} 0.84, aimed at understanding the effects of the cluster environment on the star formation history (SFH) of cluster galaxies and the assembly of the red sequence (RS). We use VLT/FORS spectroscopy, ACS/WFC optical, and NTT/SofI near-IR data to characterize SFHs as a function of color, luminosity, morphology, stellar mass, and local environment from a sample of 134 spectroscopic members. In order to increase the signal-to-noise ratio, individual galaxy spectra are stacked according to these properties. Moreover, the D4000, Balmer, CN3883, Fe4383, and C4668 indices are also quantified. The SFH analysis shows that galaxies in the blue faint-end of the RS have on average younger stars ({Delta}t {approx} 2 Gyr) than those in the red bright-end. We also found, for a given luminosity range, differences in age ({Delta}t {approx} 0.5-1.3 Gyr) as a function of color, indicating that the intrinsic scatter of the RS may be due to age variations. Passive galaxies in the blue faint-end of the RS are preferentially located in the low density areas of the cluster, likely being objects entering the RS from the 'blue cloud'. It is likely that the quenching of the star formation of these RS galaxies is due to interaction with the intracluster medium. Furthermore, the SFH of galaxies in the RS as a function of stellar mass reveals signatures of 'downsizing' in the overall cluster.

  14. Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil.

    PubMed

    Barros, C M A R; Araujo-Neto, A P; Lopes, T R; Barros, M A L; Motta, F J N; Canalle, R; Nunes, L C C; Rey, J A; Burbano, R R; Lima-Barros, M A; Yoshioka, F K N; Pinto, G R

    2014-01-01

    Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in the TCF7L2 gene, the noncoding single nucleotide polymorphisms (SNPs) rs7903146 (C/T) and rs12255372 (G/T), with T2D. Herein, we analyzed the association of these SNPs with T2D in a population from northeastern Brazil. Our results showed that the genotype and allele frequencies in TCF7L2 rs7903146 and rs12255372 were similar in the patient and control groups (P > 0.05). In addition, the allele frequencies were not significantly associated with T2D risk [rs7903146: odds ratio (OR) = 0.95, 95% confidence interval (CI) = 0.52-1.76, P = 1.00, and rs12255372: OR = 1.38, 95%CI = 0.72-2.62, P = 0.41]. These data suggest that the TCF7L2 SNPs rs7903146 and rs12255372 may not significantly contribute to T2D susceptibility in this population. However, our results may reflect the small number of subjects. Alternatively, these results may be attributable to specific ethnic effects, as most of the previously reported associations were demonstrated with predominantly European populations. To reach a definitive conclusion on the role of such gene variants for T2D in mixed populations, additional efforts are necessary to replicate this study with larger populations from areas with more ethnic heterogeneity. PMID:25299103

  15. Association between Insulin-Like Growth Factor 1 Gene rs12423791 or rs6214 Polymorphisms and High Myopia: A Meta-Analysis

    PubMed Central

    Guo, Lan; Du, Xueying; Lu, Ciyong; Zhang, Wei-Hong

    2015-01-01

    Objective To evaluate the association of insulin-like growth factor 1 gene rs12423791 and rs6214 polymorphisms with high myopia. Methods An electronic search was conducted on PubMed, Embase, the Cochrane Library and the Chinese Biological Abstract Database for articles published prior to May 6, 2014. A meta-analysis was performed using Revman 5.1 and Stata 12.0, and the odds ratios with 95% confidence intervals were calculated in fixed or random effects models based on the results of the Q test. The subgroup analysis was conducted on the basis of the various regions, the sensitivity analysis was also performed to evaluate the stability of the results, and the publication bias was evaluated by a funnel plot and Egger’s linear regression analysis. Results This comprehensive meta-analysis included 2808 high myopia patients and 2778 controls from five unrelated studies. The results demonstrated that the significant association was not present in any genetic models between IGF-1 rs12423791 or rs6214 and high myopia. However, subgroup analysis indicated that rs12423791 polymorphism was associated with high myopia in the Chinese populations in the allelic contrast model (C vs. G: OR=1.24, 95% CI=1.04-1.48 in the fixed-effects model), the dominant model (CC+CG vs. GG: OR=1.40, 95% CI=1.16-1.69 in the fixed-effects model), and the codominant model (CG vs. GG: OR=1.37, 95% CI= 1.12-1.68 in the fixed-effects model). Additionally, none of the individual studies significantly affected the association between IGF-1 rs12423791 and high myopia, according to sensitivity analysis. Conclusion This meta-analysis shows that IGF-1 rs12423791 or rs6214 gene polymorphism is not associated with high myopia. PMID:26076017

  16. Binarity and multiperiodicity in high-amplitude delta Scuti stars

    E-print Network

    A. Derekas; L. L. Kiss; B. Csak; J. Griffin; C. Lindstrom; Sz. Meszaros; P. Szekely; M. C. B. Ashley; T. R. Bedding

    2005-09-16

    We present our first results for a sample of southern high-amplitude delta Scuti stars (HADS), based on a spectrophotometric survey started in 2003. For CY Aqr and AD CMi, we found very stable light and radial velocity curves; we confirmed the double-mode nature of ZZ Mic, BQ Ind and RY Lep. Finally, we detected gamma-velocity changes in RS Gru and RY Lep

  17. Novel Oversampling Technique for Improving Signal-to-Quantization Noise Ratio on Accelerometer-Based Smart Jerk Sensors in CNC Applications

    PubMed Central

    Rangel-Magdaleno, Jose J.; Romero-Troncoso, Rene J.; Osornio-Rios, Roque A.; Cabal-Yepez, Eduardo

    2009-01-01

    Jerk monitoring, defined as the first derivative of acceleration, has become a major issue in computerized numeric controlled (CNC) machines. Several works highlight the necessity of measuring jerk in a reliable way for improving production processes. Nowadays, the computation of jerk is done by finite differences of the acceleration signal, computed at the Nyquist rate, which leads to low signal-to-quantization noise ratio (SQNR) during the estimation. The novelty of this work is the development of a smart sensor for jerk monitoring from a standard accelerometer, which has improved SQNR. The proposal is based on oversampling techniques that give a better estimation of jerk than that produced by a Nyquist-rate differentiator. Simulations and experimental results are presented to show the overall methodology performance. PMID:22412337

  18. A non-LTE spectral analysis of the 3He and 4He isotopes in the HgMn star ? Cancri

    NASA Astrophysics Data System (ADS)

    Maza, Natalia L.; Nieva, María-Fernanda; Przybilla, Norbert

    2014-12-01

    Aims: We present a pilot study on non-local thermodynamic equilibrium (NLTE) line-formation computations for the isotopes 3He and 4He in the mercury-manganese star ? Cancri. The impact of NLTE effects on the determination of isotopic abundances and the vertical stratification of helium in the atmosphere is investigated. Methods: Modern NLTE line-formation computations were employed to analyse a high-resolution and high signal-to-noise ratio ESO-VLT/UVES spectrum of ? Cnc. The atmospheric parameters were determined from fitting the hydrogen Balmer lines and the spectral energy distribution. Multiple He i lines were investigated, including He i ?4921 Å and ?6678 Å, which show the widest isotopic splits. Results: Half of the observed He i lines in the spectrum of ? Cnc show significant NLTE strengthening, the effects are strongest in the red lines He i?5875 Å and He i?6678 Å. NLTE abundances from individual He i lines are up to a factor of ~3 lower than LTE values. Helium is found to be stratified in the atmosphere of ? Cnc. While the LTE analysis indicates a step-like profile of the helium abundance, a gradual decrease with height is indicated by the NLTE analysis. A 3He/4He ratio of ~0.25-0.30 is found. With the available data it cannot be decided whether the two isotopes follow the same stratification profile, or not. Conclusions: This work implies that NLTE effects may be ubiquitous in the atmospheres of HgMn stars and may have a significant impact on abundance determinations and the interpretation of the vertical abundance stratification of elements. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 076.B-0055(A).Figures 3 and 4 are available in electronic form at http://www.aanda.org

  19. Associations between Cox-2 rs20417 and rs5275 polymorphisms and the risk of hepatocellular carcinoma: a meta analysis.

    PubMed

    Wu, Hexing; Wu, Xiangwei; Wan, Guoxing; Zhang, Shijie

    2014-01-01

    Genetic polymorphisms of cyclooxygenase-2 (Cox-2) gene have been implicated in the susceptibility to hepatocellular carcinoma (HCC), but the findings from published studies are conflicting and inconclusive. To obtain a more precise estimate of the association of Cox-2 polymorphisms with HCC risk, we performed a meta-analysis of eight eligible case-control studies identified through an extensive online database search of PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang and Chinese Biomedicine Database; after exclusion, 2324 cases and 2604 controls were included. The pooled odds ratios with corresponding 95% confidence intervals were calculated to assess associations, using fixed- or random-effect models. In addition, subgroup analysis by ethnicity and sensitivity analysis were performed. Our results showed that the Cox-2 rs20417 (-765 G/C) polymorphism was not associated with HCC risk in the studied genetic contrast modes (C vs. G, GC vs. GG, and CC + GC vs. GG). No significant association was found with ethnic groups examined (P > 0.05). Similarly, no significant association of the Cox-2 rs5275 (+ 8473 T/C) polymorphism and HCC risk was found under any of the studied contrasts (C vs. T, TC vs. TT, CC vs. TT, CC + TC vs. TT, CC vs. TC + TT). The present meta-analysis, combining all currently available data, suggests no significant associations of either Cox-2 polymorphism with HCC risk. Further studies with a larger sample size are needed to determine the association in different ethnicities. PMID:25400773

  20. 27/10/2010 12:48AGU: Highlatitude geomagnetically induced current events observed on very low frequency radio wave receiver systems Page 1 of 2http://europa.agu.org/?view=article&uri=/journals/rs/rs1002/2009RS004215/2009RS004215.xml&t=

    E-print Network

    Ulich, Thomas

    frequency radio wave receiver systems Page 1 of 2http://europa.agu.org/?view=article&uri=/journals/rs/rs1002 Abstract Highlatitude geomagnetically induced current events observed on very low frequency radio wave. Kavanagh (2010), Highlatitude geomagnetically induced current events observed on very low frequency radio

  1. Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility

    PubMed Central

    Chen, Guangyuan; Fu, Xiuhua; Wang, Guangyu; Liu, Guiyou; Bai, Xiuping

    2015-01-01

    Large-scale genome-wide association studies (GWAS) have revealed that rs10757278 polymorphism (or its proxy rs1333049) on chromosome 9p21 is associated with myocardial infarction (MI) susceptibility in individuals of Caucasian ancestry. Following studies in other populations investigated this association. However, some of these studies reported weak or no significant association. Here, we reevaluated this association using large-scale samples by searching PubMed and Google Scholar databases. Our results showed significant association between rs10757278 polymorphism and MI with p = 6.09 × 10?22, odds ratio (OR) = 1.29, 95% confidence interval (CI) 1.22–1.36 in pooled population. We further performed a subgroup analysis, and found significant association between rs10757278 polymorphism and MI in Asian and Caucasian populations. We identified that the association between rs10757278 polymorphism and MI did not vary substantially by excluding any one study. However, the heterogeneity among the selected studies varies substantially by excluding the study from the Pakistan population. We found even more significant association between rs10757278 polymorphism and MI in pooled population, p = 3.55 × 10?53, after excluding the study from the Pakistan population. In summary, previous studies reported weak or no significant association between rs10757278 polymorphism and MI. Interestingly, our analysis suggests that rs10757278 polymorphism is significantly associated with MI susceptibility by analyzing large-scale samples. PMID:26006241

  2. Robust GRAPPA-Accelerated Diffusion-Weighted Readout-Segmented (RS)-EPI

    PubMed Central

    Holdsworth, Samantha J.; Skare, Stefan; Newbould, Rexford D.; Bammer, Roland

    2010-01-01

    Readout segmentation (RS-EPI) has been suggested as a promising variant to echo-planar imaging (EPI) for high-resolution imaging, particularly when combined with parallel imaging. This work details some of the technical aspects of diffusion-weighted (DW)-RS-EPI, outlining a set of reconstruction methods and imaging parameters that can both minimize the scan time and afford high-resolution diffusion imaging with reduced distortions. These methods include an efficient generalized autocalibrating partially parallel acquisition (GRAPPA) calibration for DW-RS-EPI data without scan time penalty, together with a variant for the phase correction of partial Fourier RS-EPI data. In addition, the role of pulsatile and rigid-body brain motion in DW-RS-EPI was assessed. Corrupt DW-RS-EPI data arising from pulsatile nonlinear brain motion had a prevalence of ~7% and were robustly identified via k-space entropy metrics. For DW-RS-EPI data corrupted by rigid-body motion, we showed that no blind overlap was required. The robustness of RS-EPI toward phase errors and motion, together with its minimized distortions compared with EPI, enables the acquisition of exquisite 3 T DW images with matrix sizes close to 5122. PMID:19859974

  3. Design and application of fog monitoring system based on RS and GIS

    Microsoft Academic Search

    Fengbin Zhengl; Baojun Qiao; Jun Ma; Shenshen Li

    2009-01-01

    It is very importance to monitor fog for its impact on traffic and human health. With the development of remote sensing (RS) and geographical information system (GIS) technologies, the monitoring of fog can be easily and quickly. In this paper, a fog monitoring system based on RS and GIS was built up. Firstly, by the thresholds in different bands, the

  4. PCLO rs2522833 impacts HPA system activity in healthy young adults

    Microsoft Academic Search

    C Kuehner; S Huffziger; S H Witt; M Rietschel

    2011-01-01

    Recent genetic studies showed evidence for a role of the single-nucleotide polymorphism rs2522833 within the PCLO gene in the etiology of major depression, and rs2522833 has been shown to modulate hypothalamic pituitary adrenal (HPA) axis activity during antidepressant treatment. Monoaminergic modulation of the HPA system may be one possible pathomechanism by which PCLO exerts its effect on depression. In the

  5. Characterization of Fpr-rs8, an Atypical Member of the Mouse Formyl Peptide Receptor Gene Family

    Microsoft Academic Search

    H. Lee Tiffany; Ji-Liang Gao; Ester Roffe; Joan M. G. Sechler; Philip M. Murphy

    2011-01-01

    The formyl peptide receptor gene family encodes G protein-coupled receptors for phagocyte chemoattractants, including bacteria- and mitochondria-derived N-formylpeptides. The human family has 3 functional genes, whereas the mouse family has 7 functional genes and 2 possible pseudogenes (?Fpr-rs2 and ?Fpr-rs3). Here we characterize ?Fpr-rs2, a duplication of Fpr-rs2. Compared to Fpr-rs2, the ?Fpr-rs2 ORF is 186 nucleotides shorter but 98%

  6. The emerging landscape of circular RNA ciRS-7 in cancer (Review).

    PubMed

    Peng, Li; Yuan, Xiao Qing; Li, Guan Cheng

    2015-06-01

    Circular RNAs (circRNAs) are a novel class of non?coding RNA molecules ubiquitously present in the cytoplasm of eukaryotic cells. CircRNAs are generated from exons or introns via multiple mechanisms. A recently identified circRNA, ciRS-7, can regulate the activities of miRNAs, mRNAs, and RBP to exert specific biological effects. Also, ciRS-7 acts as a natural competing endogenous RNA, a.k.a. 'super sponge' of microRNA-7 (miR-7) that sequesters and competitively inhibits the activity of miR-7. This competition between ciRS-7 and miR-7 may have profound effects on oncogenesis. This review will summarize the origin and functions of ciRS-7 and discuss the relationship among ciRS-7, its target molecules and cancer. PMID:25873049

  7. The ARIES-RS power core -- Recent development in Li/V designs

    SciTech Connect

    Sze, D.K.; Billone, M.C.; Hua, T.Q. [and others

    1997-04-01

    The ARIES-RS fusion power plant design study is based on reversed-shear (RS) physics with a Li/V (lithium breeder and vanadium structure) blanket. The reversed-shear discharge has been documented in many large tokamak experiments. The plasma in the RS mode has a high beta, low current, and low current drive requirements. Therefore, it is an attractive physics regime for a fusion power plant. The blanket system based on a Li/V has high temperature operating capability, good tritium breeding, excellent high heat flux removal capability, long structural life time, low activation, low after heat and good safety characteristics. For these reasons, the ARIES-RS reactor study selected Li/V as the reference blanket. The combination of attractive physics and attractive blanket engineering is expected to result in a superior power plant design. This paper summarizes the power core design of the ARIES-RS power plant study.

  8. Association of IL-1? rs17561 and IL-1 RN rs315952 polymorphisms with Tourette syndrome: a family-based study

    PubMed Central

    He, Fan; Shao, Xiaohui; Yi, Mingji; Wang, Yu; Wang, Chuan-Yue; Liu, Shiguo

    2015-01-01

    Aim: Immune system dysregulation has been implicated to play a key role in pathogenesis of Tourette syndrome (TS). IL-1? and IL-1RN are important inflammatory cytokines that mediate the inflammation. In this study, we investigated the relationship between single-nucleotide polymorphisms (SNPs) of IL-1? and IL-1RN and the susceptibility to TS in Chinese Han population. Methods: A total of 276 children with TS and their parents were recruited in the study. All DNA from our subjects were genotyped for SNPs of IL-1? rs17561 and IL-1RN rs315952 using predesigned TaqMan SNP genotyping assay. The genetic contributions of two polymorphisms were evaluated using transmission disequilibrium test (TDT) and haplotype relative risk (HRR) design. In addition, to increase the efficiency of the test, the haplotype-based HRR (HHRR) was performed. Results: No significant differences were observed in allelic and genotypic frequency of rs17561 in IL-1? and rs315952 in IL-1RN between the transmitted group and non-transmitted group (for IL-1? rs17561: TDT=0.890, df=1, P=0.402; HRR=1.011, X2=3.016, P=0.082, 95% CI=0.999-1.024; for IL-1RN rs315952: TDT=0.095, df=1, P=0.805; HRR=0.984, X2=0.008, P=0.929, 95% CI=0.695-1.394). Similarly, the analysis of HHRR also did not support a significant association (for IL-1? rs17561: HHRR=1.226, X2=0.915, P=0.339, 95% CI=0.807-1.863; for IL-1RN rs315952: HHRR=0.963, X2=0.094, P=0.759, 95% CI=0.758-1.225). Conclusion: Our results suggest that IL-1? rs17561 and IL-1RN rs315952 polymorphisms may not be associated with susceptibility to TS in Chinese Han population. However, the results still need to be replicated in a larger sample size and different populations. PMID:26097611

  9. Study on parallel and distributed management of RS data based on spatial database

    NASA Astrophysics Data System (ADS)

    Chen, Yingbiao; Qian, Qinglan; Wu, Hongqiao; Liu, Shijin

    2009-10-01

    With the rapid development of current earth-observing technology, RS image data storage, management and information publication become a bottle-neck for its appliance and popularization. There are two prominent problems in RS image data storage and management system. First, background server hardly handle the heavy process of great capacity of RS data which stored at different nodes in a distributing environment. A tough burden has put on the background server. Second, there is no unique, standard and rational organization of Multi-sensor RS data for its storage and management. And lots of information is lost or not included at storage. Faced at the above two problems, the paper has put forward a framework for RS image data parallel and distributed management and storage system. This system aims at RS data information system based on parallel background server and a distributed data management system. Aiming at the above two goals, this paper has studied the following key techniques and elicited some revelatory conclusions. The paper has put forward a solid index of "Pyramid, Block, Layer, Epoch" according to the properties of RS image data. With the solid index mechanism, a rational organization for different resolution, different area, different band and different period of Multi-sensor RS image data is completed. In data storage, RS data is not divided into binary large objects to be stored at current relational database system, while it is reconstructed through the above solid index mechanism. A logical image database for the RS image data file is constructed. In system architecture, this paper has set up a framework based on a parallel server of several common computers. Under the framework, the background process is divided into two parts, the common WEB process and parallel process.

  10. Detecting the Companions and Ellipsoidal Variations of RS CVn Primaries. I. ? Geminorum

    NASA Astrophysics Data System (ADS)

    Roettenbacher, Rachael M.; Monnier, John D.; Henry, Gregory W.; Fekel, Francis C.; Williamson, Michael H.; Pourbaix, Dimitri; Latham, David W.; Latham, Christian A.; Torres, Guillermo; Baron, Fabien; Che, Xiao; Kraus, Stefan; Schaefer, Gail H.; Aarnio, Alicia N.; Korhonen, Heidi; Harmon, Robert O.; ten Brummelaar, Theo A.; Sturmann, Judit; Sturmann, Laszlo; Turner, Nils H.

    2015-07-01

    To measure the properties of both components of the RS Canum Venaticorum binary ? Geminorum (? Gem), we directly detect the faint companion, measure the orbit, obtain model-independent masses and evolutionary histories, detect ellipsoidal variations of the primary caused by the gravity of the companion, and measure gravity darkening. We detect the companion with interferometric observations obtained with the Michigan InfraRed Combiner at Georgia State University’s Center for High Angular Resolution Astronomy Array with a primary-to-secondary H-band flux ratio of 270 ± 70. A radial velocity curve of the companion was obtained with spectra from the Tillinghast Reflector Echelle Spectrograph on the 1.5 m Tillinghast Reflector at Fred Lawrence Whipple Observatory. We additionally use new observations from the Tennessee State University Automated Spectroscopic and Photometric Telescopes (AST and APT, respectively). From our orbit, we determine model-independent masses of the components ({M}1=1.28+/- 0.07 {M}? , {M}2=0.73+/- 0.03 {M}? ), and estimate a system age of 5\\mp 1 Gyr. An average of the 27 year APT light curve of ? Gem folded over the orbital period (P=19.6027+/- 0.0005 days) reveals a quasi-sinusoidal signature, which has previously been attributed to active longitudes 180° apart on the surface of ? Gem. With the component masses, diameters, and orbit, we find that the predicted light curve for ellipsoidal variations due to the primary star partially filling its Roche lobe potential matches well with the observed average light curve, offering a compelling alternative explanation to the active longitudes hypothesis. Measuring gravity darkening from the light curve gives ? \\lt 0.1, a value slightly lower than that expected from recent theory.

  11. Energy Star 

    E-print Network

    Reihl, K.; Tullos, A.

    2012-01-01

    to design, track, and report energy use of projects ESL-KT-12-10-08 CATEE 2012: Clean Air Through Energy Efficiency Conference, Galveston, TX, October 9-11, 2012 Source: 2006 Lunch & Learn Workshop. ?Energy Star ? New Building Design.? Karen P. Butler.... US Environmental Protection Agency. ESL-KT-12-10-08 CATEE 2012: Clean Air Through Energy Efficiency Conference, Galveston, TX, October 9-11, 2012 Source: 2006 Lunch & Learn Workshop. ?Energy Star ? New Building Design.? Karen P. Butler. US...

  12. Star struck

    NASA Astrophysics Data System (ADS)

    Closer to home, astronomers using the Hubble Space Telescope recently took a close-up photograph of the red supergiant star Betelgeuse, providing astronomers with their first direct look at the surface of a star besides the Sun.Andrea Dupree of the Harvard-Smithsonian Center for Astrophysics and Ronald Gilliland of the Space Telescope Science Institute presented pictures of Betelgeuse revealing an extended atmosphere and a surface marked by a bright spot more than 10 Earths wide and as much as 2000 K warmer than the rest of the surface.

  13. RASSF1A and the rs2073498 Cancer Associated SNP

    PubMed Central

    Donninger, Howard; Barnoud, Thibaut; Nelson, Nick; Kassler, Suzanna; Clark, Jennifer; Cummins, Timothy D.; Powell, David W.; Nyante, Sarah; Millikan, Robert C.; Clark, Geoffrey J.

    2011-01-01

    RASSF1A is one of the most frequently inactivated tumor suppressors yet identified in human cancer. It is pro-apoptotic and appears to function as a scaffolding protein that interacts with a variety of other tumor suppressors to modulate their function. It can also complex with the Ras oncoprotein and may serve to integrate pro-growth and pro-death signaling pathways. A SNP has been identified that is present in approximately 29% of European populations [rs2073498, A(133)S]. Several studies have now presented evidence that this SNP is associated with an enhanced risk of developing breast cancer. We have used a proteomics based approach to identify multiple differences in the pattern of protein/protein interactions mediated by the wild type compared to the SNP variant protein. We have also identified a significant difference in biological activity between wild type and SNP variant protein. However, we have found only a very modest association of the SNP with breast cancer predisposition. PMID:22649770

  14. STAR Highlights

    E-print Network

    Hiroshi Masui; for the STAR Collaboration

    2011-06-29

    We report selected results from STAR collaboration at RHIC, focusing on jet-hadron and jet-like correlations, quarkonium suppression and collectivity, di-electron spectrum in both p+p and Au+Au, and higher moments of net-protons as well as azimuthal anisotropy from RHIC Beam Energy Scan program.

  15. Star Power

    ScienceCinema

    None

    2014-11-18

    The U.S. Department of Energy's Princeton Plasma Physics Laboratory has released ''Star Power,'' a new informational video that uses dramatic and beautiful images and thought-provoking interviews to highlight the importance of the Laboratory's research into magnetic fusion.

  16. Star Power

    NSDL National Science Digital Library

    Twin Cities Public Television

    2010-01-01

    In this activity, learners create a star show and discover how they can prevent light pollution. Using simple materials, learners first design constellation boxes. Next, learners use their constellation boxes and desk lamps to explore how city lights impact the visibility of constellations. Finally, learners design shields to reduce light pollution and increase the visibility of constellations.

  17. Brittle Star

    USGS Multimedia Gallery

    A tiny brittle star (the central disc is smaller than a dime) clings to the branches of a soft coral in a sample bucket brought into the shipboard laboratory from a submersible dive. This creature makes its home on the deep, dark ocean floor. ...

  18. Star Power

    SciTech Connect

    None

    2014-10-17

    The U.S. Department of Energy's Princeton Plasma Physics Laboratory has released ''Star Power,'' a new informational video that uses dramatic and beautiful images and thought-provoking interviews to highlight the importance of the Laboratory's research into magnetic fusion.

  19. Characterization of Fpr-rs8, an Atypical Member of the Mouse Formyl Peptide Receptor Gene Family

    PubMed Central

    Tiffany, H. Lee; Gao, Ji-Liang; Roffe, Ester; Sechler, Joan M.G.; Murphy, Philip M.

    2011-01-01

    The formyl peptide receptor gene family encodes G protein-coupled receptors for phagocyte chemoattractants, including bacteria- and mitochondria-derived N-formylpeptides. The human family has 3 functional genes, whereas the mouse family has 7 functional genes and 2 possible pseudogenes (?Fpr-rs2 and ?Fpr-rs3). Here we characterize ?Fpr-rs2, a duplication of Fpr-rs2. Compared to Fpr-rs2, the ?Fpr-rs2 ORF is 186 nucleotides shorter but 98% identical. Due to a deletion and frame shift, the sequences lack homology from amino acid 219–289. Both transcripts were detected constitutively in multiple immune organs; however, ?Fpr-rs2 was consistently less abundant than Fpr-rs2. LPS induced expression of ?Fpr-rs2, but not Fpr-rs2, in spleen and bone marrow. Both transcripts were detected constitutively in thioglycollate-elicited peritoneal neutrophils, whereas only Fpr-rs2 was detected in thioglycollate-elicited peritoneal macrophages. Both transcripts were induced in LPS-stimulated macrophages. ?Fpr-rs2-GFP fusion protein appeared in cytoplasm but not plasma membrane of transfected HEK 293 cells, whereas Fpr-rs2-GFP labeled only plasma membrane. Survival of ?Fpr-rs2–/– mice was 33% shorter than that of wild-type and heterozygous littermates (p < 0.05), but no signature pathology was identified. Since ?Fpr-rs2 is expressed in phagocytes and regulated by bacterial products, and may affect longevity, we propose renaming it Fpr-rs8, an atypical member of the formyl peptide receptor gene family. Copyright © 2011 S. Karger AG, Basel PMID:21691049

  20. Characterization of Fpr-rs8, an atypical member of the mouse formyl peptide receptor gene family.

    PubMed

    Tiffany, H Lee; Gao, Ji-Liang; Roffe, Ester; Sechler, Joan M G; Murphy, Philip M

    2011-01-01

    The formyl peptide receptor gene family encodes G protein-coupled receptors for phagocyte chemoattractants, including bacteria- and mitochondria-derived N-formylpeptides. The human family has 3 functional genes, whereas the mouse family has 7 functional genes and 2 possible pseudogenes (?Fpr-rs2 and ?Fpr-rs3). Here we characterize ?Fpr-rs2, a duplication of Fpr-rs2. Compared to Fpr-rs2, the ?Fpr-rs2 ORF is 186 nucleotides shorter but 98% identical. Due to a deletion and frame shift, the sequences lack homology from amino acid 219-289. Both transcripts were detected constitutively in multiple immune organs; however, ?Fpr-rs2 was consistently less abundant than Fpr-rs2. LPS induced expression of ?Fpr-rs2, but not Fpr-rs2, in spleen and bone marrow. Both transcripts were detected constitutively in thioglycollate-elicited peritoneal neutrophils, whereas only Fpr-rs2 was detected in thioglycollate-elicited peritoneal macrophages. Both transcripts were induced in LPS-stimulated macrophages. ?Fpr-rs2-GFP fusion protein appeared in cytoplasm but not plasma membrane of transfected HEK 293 cells, whereas Fpr-rs2-GFP labeled only plasma membrane. Survival of ?Fpr-rs2(-/-) mice was 33% shorter than that of wild-type and heterozygous littermates (p < 0.05), but no signature pathology was identified. Since ?Fpr-rs2 is expressed in phagocytes and regulated by bacterial products, and may affect longevity, we propose renaming it Fpr-rs8, an atypical member of the formyl peptide receptor gene family. PMID:21691049

  1. Association between miR-125a rs12976445 and survival in breast cancer patients

    PubMed Central

    Jiao, Lianghe; Zhang, Jiaxin; Dong, Yuanyuan; Duan, Bensong; Yu, Hong; Sheng, Haihui; Huang, Junxing; Gao, Hengjun

    2014-01-01

    MicroRNAs (miRNAs) act as an oncogene or a tumor suppressor by negatively regulating target genes. Genetic variants in miRNA genes confer susceptibility to cancer and risk of death in cancer patients. The aim of this study was to investigate whether miRNA polymorphisms were associated with survival in breast cancer patients. Five miRNA polymorphisms (miR-26a1 rs7372209, miR-125a rs12976445, miR-218 rs11134527, miR-423 rs6505162, and miR-608 rs4919510) were genotyped in 196 breast cancer patients. We found that miR-125a rs12976445 was significantly associated with survival in codominant, recessive, and dominant models. However, only association under the codominant model remained significant after adjustment for lymph node metastasis, TNM stage, estrogen receptor, and progesterone receptor. Furthermore, this effect remained in stratification analysis. In conclusion, our results provide evidence that miR-125a rs12976445 may serve as a prognostic biomarker for breast cancer. Further large-scale studies are required to confirm these findings. PMID:25628797

  2. High-resolution X-ray spectroscopy of the evolving shock in the 2006 outburst of RS Ophiuchi

    E-print Network

    J. -U. Ness; J. J. Drake; S. Starrfield; M. F. Bode; T. J. O'Brien; A. Evans; S. P. S. Eyres; L. A. Helton; J. P. Osborne; K. L. Page; C. Schneider; C. E. Woodward

    2008-10-11

    The evolution of the 2006 outburst of the recurrent nova RS Ophiuchi was followed with 12 X-ray grating observations with Chandra and XMM-Newton. We present detailed spectral analyses using two independent approaches. From the best dataset, taken on day 13.8 after outburst, we reconstruct the temperature distribution and derive elemental abundances. We find evidence for at least two distinct temperature components on day 13.8 and a reduction of temperature with time. The X-ray flux decreases as a power-law, and the power-law index changes from -5/3 to -8/3 around day 70 after outburst. This can be explained by different decay mechanisms for the hot and cool components. The decay of the hot component and the decrease in temperature are consistent with radiative cooling, while the decay of the cool component can be explained by the expansion of the ejecta. We find overabundances of N and of alpha-elements, which could either represent the composition of the secondary that provides the accreted material or that of the ejecta. The N overabundance indicates CNO-cycled material. From comparisons to abundances for the secondary taken from the literature, we conclude that 20-40% of the observed nitrogen could originate from the outburst. The overabundance of the alpha-elements is not typical for stars of the spectral type of the secondary in the RS Oph system, and white dwarf material might have been mixed into the ejecta. However, no direct measurements of the alpha-elements in the secondary are available, and the continuous accretion may have changed the observable surface composition.

  3. Accuracy assessment and correction of Vaisala RS92 radiosonde water vapor measurements

    NASA Astrophysics Data System (ADS)

    Miloshevich, Larry M.; VöMel, Holger; Whiteman, David N.; Leblanc, Thierry

    2009-06-01

    Relative humidity (RH) measurements from Vaisala RS92 radiosondes are widely used in research and operational applications, but their accuracy is not well characterized as a function of height, RH, and time of day (or solar altitude angle). This study compares RS92 RH measurements to simultaneous water vapor measurements from three reference instruments of known accuracy. Cryogenic frost point hygrometer measurements are used to characterize the RS92 accuracy above the 700-mbar level, microwave radiometer measurements characterize the RS92 accuracy averaged over essentially the lower troposphere, and the RS92 accuracy at the surface is characterized by a system of 6 RH probes with National Institute of Standards and Technology-traceable calibrations. The three RS92 accuracy assessments are combined to yield a detailed estimate of RS92 accuracy for all RH conditions from the surface to the lowermost stratosphere. An empirical correction is derived to remove the mean bias error, yielding corrected RS92 measurements whose bias uncertainty is independent of height or RH and is estimated to be ±4% of the measured RH value for nighttime soundings and ±5% for daytime soundings, plus an RH offset uncertainty of ±0.5% RH that is significant for dry conditions. The accuracy of an individual RS92 sounding is further characterized by the 1-? "random production variability," estimated to be ±1.5% of the measured RH value. The daytime bias correction must be used with caution, as it is only accurate for clear-sky or near-clear conditions owing to the complicated effect of clouds on the solar radiation error.

  4. Polymorphism of the rs1800896 IL10 promoter gene protects children from post-bronchiolitis asthma.

    PubMed

    Koponen, Petri; Nuolivirta, Kirsi; Virta, Miia; Helminen, Merja; Hurme, Mikko; Korppi, Matti

    2014-08-01

    Viral bronchiolitis is a major cause of hospitalization in infancy, with increased asthma risk in later childhood. However, the principal mechanisms behind post-bronchiolitic asthma have remained unclear. Previously, different cytokine polymorphisms have been associated with asthma occurrence, but no previous follow-up study has investigated cytokine polymorphisms in relation to post-bronchiolitic asthma. We hypothesized that former bronchiolitis patients with cytokine gene variants associating with Th2 cell up-regulation are at asthma risk at preschool age. Our emphasis was in IL10 rs1800896, since IL-10 has an important role in immune tolerance, and lower production of IL-10 has been associated with Th2-type immunology, and accordingly, with increased asthma risk. IL10 rs1800896, IFNG rs2430561, and IL18 rs1872387 polymorphims and their associations with asthma and allergy were studied in 135 preschool-aged children hospitalized for bronchiolitis at age 0-6 months. Parents were interviewed to record asthma and allergy from infancy to present. At age 6.4 years (mean), asthma was present in 17(12.6%), atopic eczema in 47(34.8%) and allergic rhinitis in 36(26.7%) children. IL10 rs1800896 SNP associated significantly with asthma; only 1/32 (3.1%) of those with G/G genotype had asthma (P?=?0.04). In logistic regression adjusted for gender, age and atopy, the carriage of allele A (rs1800896) was a significant risk factor for preschool asthma. IFNG rs2430561 or IL18 rs1872387 SNP's had no associations with asthma or allergy. In conclusion, IL10 rs1800896 SNP was significantly associated with preschool asthma after severe lower respiratory tract infection in early infancy. PMID:24167151

  5. 78 FR 20386 - Notice of Receipt of Petition for Decision That Nonconforming 2012 Porsche GT3RS Passenger Cars...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ...Nonconforming 2012 Porsche GT3RS Passenger Cars Are Eligible for Importation AGENCY: National...nonconforming 2012 Porsche GT3RS passenger cars that were not originally manufactured to...nonconforming 2012 Porsche GT3RS passenger cars are eligible for importation into the...

  6. RS-Algo: an Algorithm for Improved Memory Utilization in Continuous Query System under Asynchronous Data Streams

    E-print Network

    Plale, Beth

    RS-Algo: an Algorithm for Improved Memory Utilization in Continuous Query System under Asynchronous experimentally evaluate the RS-Algo algorithm for dynamically adjusting sliding window sizes used in database joins to reflect current stream rates. In this TR we provide detailed results of measurements of the RS-Algo

  7. Human Resources rs_msc83 Page 1 of 10 Date issued: 25-Jul-13 Recruit & Select

    E-print Network

    Hickman, Mark

    Human Resources ­ rs_msc83 Page 1 of 10 Date issued: 25-Jul-13 Recruit & Select Human Resources the Previous/Next buttons to view the various job vacancies. #12;Human Resources ­ rs_msc83 Page 4 of 10 Date description here to open a PDF version of the full Position Description. #12;Human Resources ­ rs_msc83 Page 5

  8. The crystal field theory for D 2d symmetric complexes and the splitting of d-orbitals of Mo 5+ in Mo[S 2 CN(C 2 H 5 ) 2 ] 4 I 3

    Microsoft Academic Search

    Yang Jian-Hua; Zhou Kang-Wei

    1989-01-01

    The energy order assignment of the d-orbitals of Mo5+ in Mo[S2CN(C2H5)2]4I3 given by Jasimet al. (1985) is restudied and corrected. It is indicated that, in general, the energy order of the d-orbitals of D2d symmetric complexes is depending on the bond angles and bond lengths of the ligands, thus there cannot be any universal energy order.

  9. Synthesis, spectroscopic characterization, and x-ray structural determination of W(CO)/sub 4/(PR/sub 3/)CNC/sub 6/H/sub 4/(PR/sub 3/ (R = Ph, Et)

    SciTech Connect

    Rommel, J.S.; Weinrach, J.B.; Grubisha, D.S.; Bennett, D.W.

    1988-08-24

    Two bimetallic complexes containing 1,4-diisocyanobenzene as a bridging ligand have been prepared and examined by x-ray crystallography and /sup 13/C NMR, /sup 31/P NMR, and infrared spectroscopies. W(CO)/sub 4/(PEt/sub 3/)CNC/sub 6/H/sub 4/NCW(CO)/sub 4/(PEt/sub 3/) (1) and W(CO)/sub 4/(PPh/sub 3/)CNC/sub 6/H/sub 4/NCW(CO)/sub 4/(PPh/sub 3/) (2) both crystallized in the same space group in very similar packing environments. Crystal data: for 1, monoclinic space group P2/sub 1//n,a = 7.780 (2) /angstrom/, b = 15.930 (3) /angstrom/, c = 14.137 (6) /angstrom/, /beta/ = 99.56 (3)/degree/, Z = 2, R = 0.040; for 2, monoclinic space group P2/sub 1//n, a = 11.641 (2) /angstrom/, b = 16.970 (2) /angstrom/, c = 12.463 (2), /angstrom/, /beta/ = 101.24 (1)/degree/, Z = 2, R = 0.047; NMR chemical shifts and vibrational frequencies for CNC/sub 6/H/sub 4/NC experience significant changes upon coordination, and the presence of an organophosphine ligand in the metal coordination sphere causes the diisocyanide to experience in-plane bends of 10.8/degrees/ for 1 and 4.2/degree/ for 2. In spite of strong evidence for the M-CNR back-bonding, the C-N bond length varies only negligibly among 1, 2, and CNC/sub 6/H/sub 4/NC, the free ligand. 20 references, 2 figures, 8 tables.

  10. Spectroscopy: Star Light, Star Bright

    NSDL National Science Digital Library

    This is a student reading about the different types of spectra: continuous, absorption, and emission. Learners will read about the differences between each and see graphical representations of each. This activity is from the Stanford Solar Center's All About the Sun: Sun and Stars activity guide for Grades 5-8 and can also accompany the Stanford Solar Center's Build Your Own Spectroscope activity.

  11. Cephalopods in neuroscience: regulations, research and the 3Rs.

    PubMed

    Fiorito, Graziano; Affuso, Andrea; Anderson, David B; Basil, Jennifer; Bonnaud, Laure; Botta, Giovanni; Cole, Alison; D'Angelo, Livia; De Girolamo, Paolo; Dennison, Ngaire; Dickel, Ludovic; Di Cosmo, Anna; Di Cristo, Carlo; Gestal, Camino; Fonseca, Rute; Grasso, Frank; Kristiansen, Tore; Kuba, Michael; Maffucci, Fulvio; Manciocco, Arianna; Mark, Felix Christopher; Melillo, Daniela; Osorio, Daniel; Palumbo, Anna; Perkins, Kerry; Ponte, Giovanna; Raspa, Marcello; Shashar, Nadav; Smith, Jane; Smith, David; Sykes, António; Villanueva, Roger; Tublitz, Nathan; Zullo, Letizia; Andrews, Paul

    2014-03-01

    Cephalopods have been utilised in neuroscience research for more than 100 years particularly because of their phenotypic plasticity, complex and centralised nervous system, tractability for studies of learning and cellular mechanisms of memory (e.g. long-term potentiation) and anatomical features facilitating physiological studies (e.g. squid giant axon and synapse). On 1 January 2013, research using any of the about 700 extant species of "live cephalopods" became regulated within the European Union by Directive 2010/63/EU on the "Protection of Animals used for Scientific Purposes", giving cephalopods the same EU legal protection as previously afforded only to vertebrates. The Directive has a number of implications, particularly for neuroscience research. These include: (1) projects will need justification, authorisation from local competent authorities, and be subject to review including a harm-benefit assessment and adherence to the 3Rs principles (Replacement, Refinement and Reduction). (2) To support project evaluation and compliance with the new EU law, guidelines specific to cephalopods will need to be developed, covering capture, transport, handling, housing, care, maintenance, health monitoring, humane anaesthesia, analgesia and euthanasia. (3) Objective criteria need to be developed to identify signs of pain, suffering, distress and lasting harm particularly in the context of their induction by an experimental procedure. Despite diversity of views existing on some of these topics, this paper reviews the above topics and describes the approaches being taken by the cephalopod research community (represented by the authorship) to produce "guidelines" and the potential contribution of neuroscience research to cephalopod welfare. PMID:24385049

  12. ROSAT all-sky survey observations of X-ray variability in cool giant stars

    NASA Technical Reports Server (NTRS)

    Haisch, Bernhard; Schmitt, J. H. M. M.

    1994-01-01

    We have identified 24 active late-type giant stars, including 11 RS CVn systems, with soft X-ray count rates high enough to allow the detection of statistically significant variability on a Roentgen Satellite (ROSAT) orbital timescale (96 minutes) as observed by the Position Sensitive Proportional Counter (PSPC) during the all-sky survey. Our sensitivity typically lies in the range of 10% - 25%, depending on the source count rate. Comparison is made to the daily, nonflare solar soft X-ray variability as observed by the Solrad satellites during solar minimum in 1969 and solar maximum in 1975. Seven of the 24 stars show significant variability; in two of these cases (HR 3922 and HR 8448) major flares were observed in which the peak count rate is enhanced by at least a factor of 3 above quiescent. While HR 3922 (G5 III) is not (yet) classified as an RS CVn star, its flare is more energetic (3 x 10(exp 31) ergs/s) than previously observed RS CVn flares. The apparently single giant HR 8167 (G8 III) also shows two flares. While one might expect to find an anticorrelation between saturated coronae and variability, we find no evidence of this: the two stars in our sample with the highest ratio of f(sub x)/f(sub v) both show variability. We also point out that Capella (G6 III + F9 III) is one of the stars manifesting variability.

  13. First Zeeman Doppler imaging of a cool star using all four Stokes parameters

    E-print Network

    Rosén, Lisa; Wade, Gregg A

    2015-01-01

    Magnetic fields are ubiquitous in active cool stars but they are in general complex and weak. Current Zeeman Doppler imaging (ZDI) studies of cool star magnetic fields chiefly employ circular polarization observations because linear polarization is difficult to detect and requires a more sophisticated radiative transfer modeling to interpret. But it has been shown in previous theoretical studies, and in the observational analyses of magnetic Ap stars, that including linear polarization in the magnetic inversion process makes it possible to correctly recover many otherwise lost or misinterpreted magnetic features. We have obtained phase-resolved observations in all four Stokes parameters of the RS CVn star II Peg at two separate epochs. Here we present temperature and magnetic field maps reconstructed for this star using all four Stokes parameters. This is the very first such ZDI study of a cool active star. Our magnetic inversions reveal a highly structured magnetic field topology for both epochs. The strengt...

  14. Role of TLR4??rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease

    PubMed Central

    Ao, Ran; Wang, Ying; Zhnag, Dao-Rong; Du, Ya-Qi

    2015-01-01

    Objective. The present meta-analysis investigated the contribution of TLR4 rs4986790A>G and rs4986791C>T genetic polymorphisms in increasing the risk of inflammatory bowel disease (IBD). Methods. Databases were searched using a combination of keywords related to TLR4 and IBD. Relevant studies were selected based on strict inclusion and exclusion criteria. Meta-analysis of the data extracted from the selected studies was performed using CMA 2.0 statistical analysis software. Results. Out of the 70 studies retrieved by database search, only 13 studies were eligible for inclusion in this meta-analysis and these 13 studies contained a total number of 4409 IBD patients and 5693 healthy controls. The meta-analysis results demonstrated that TLR4 rs4986790A>G polymorphism is associated with an increased risk of IBD (allele model: OR = 1.268, 95% CI = 1.124~1.431, and P < 0.001; dominant model: OR = 1.240, 95% CI = 1.090~1.409, and P = 0.001). Similarly, TLR4 rs4986791C>T polymorphism also conferred an increased risk of IBD (allele model: OR = 1.259, 95% CI = 1.092~1.453, and P = 0.002; dominant model: OR = 1.246, 95% CI = 1.072~1.447, and P = 0.004). Conclusion. Our meta-analysis results demonstrate that TLR4 rs4986790A>G and rs4986791C>T genetic polymorphisms are associated with the etiopathogenesis of IBD. PMID:26089865

  15. TIM-1 rs41297579 G>A (-1454) and TIM-4 rs7700944 gene polymorphisms as possible risk factor for rheumatoid arthritis: relation to activity and severity.

    PubMed

    Mosaad, Y M; El-Bassiony, S R; El-Ghaweet, A E; Elhindawy, M M; El-Deek, B S; Sultan, W A

    2015-08-01

    This study was aimed to evaluate the impact of both TIM-1 rs41297579 G>A (-1454) and TIM-4 rs7700944 polymorphisms on susceptibility to rheumatoid arthritis (RA) in a cohort of Egyptian population and to evaluate for the first time their relation to activity, severity, disease-related disability and erosion. TIM-1 rs41297579 G>A (-1454) and TIM-4 rs7700944 gene polymorphisms were typed by RFLP for 128 patients with RA and 125 healthy controls. The A allele, A-containing genotypes (GA and AA) of the TIM-4 and GA haplotype were present with significant higher frequency in patients with RA than healthy controls (Pc  < 0.001). These findings suggest that the A allele, A-containing genotypes (GA and AA) and GA haplotype may be a susceptibility risk factor for RA [OR = 5.83 (3.6-9.4), OR = 9.41 (5.0-17.6) and OR = 4.21 (1.07-19.2), respectively]. No associations were found between TIM genotypes and disease activity, severity or presence of erosion. However, the RA patients with GA genotype of TIM-4 have higher grade of rheumatoid factor (RF) positivity (P = 0.018), and have worse disease-related disability (P = 0.007) and worse pain (0.025). TIM-4 rs7700944 and not TIM-1 rs41297579 G>A (-1454) is associated with RA in the present cohort of Egyptian and may be a risk factor for development of RA in Egyptian. Both SNPs have no effect on disease activity, severity or erosion. However, TIM-4 GA genotype is associated with higher grade of RF positivity and worse disease-related disability and pain. PMID:25899833

  16. Association Study between Coronary Artery Disease and rs1333049 and rs10757274 Polymorphisms at 9p21 Locus in South-West Iran

    PubMed Central

    Foroughmand, Ali Mohammad; Nikkhah, Emad; Galehdari, Hamid; Jadbabaee, Mohammad Hossin

    2015-01-01

    Objective Coronary artery disease (CAD) is a multi-factorial and heterogenic disease with atherosclerosis plaques formation in internal wall of coronary artery. Plaque formation results to limitation of the blood reaching to myocardium leading to appearance of some problems, such as ischemia, sudden thrombosis veins and myocardial infarction (MI). Several environmental and genetic factors are involved in prevalence and incident of CAD as follows: hypertension, high low density lipoprotein-cholesterol (LDL-C), age, diabetes mellitus, family history of early-onset heart disease and smoking. According to genome wide association studies (GWAS), five polymorphisms in the 9p21 locus seem to be associated with the CAD. We aimed to evaluate the remarkable association of two polymorphisms at 9p21 locus, rs1333049 and rs10757274, with CAD. Materials and Methods This experimental study was conducted in Golestan, Aria Hospitals and Genetics Lab of Shahid Chamran University in the city of Ahvaz, Iran, in 2010- 2011. The collected blood samples belonging to 170 CAD patients (case group) and 100 healthy individuals (control group) were analyzed by tetra-primer amplification refractory mutation system (ARMS)-polymerase chain reaction (PCR) technique. The results were analyzed using software package used for statistical analysis (SPSS; SPSS Inc., USA) version 16. A value of p<0.05 and an odd ratio (OR) with 95% confidence intervals (CI) were considered significant. Results The frequencies of CC, CG and GG genotypes for rs1333049 polymorphism in patients were 18.2, 65.3 and 16.5%, while in controls, the related values were 25, 67 and 8%, respectively. GG genotypes of rs1333049 polymorphism in CAD patients were more than control cases (OR: 0.354, 95%CI: 0.138-0.912, p=0.032). The frequencies of AA, AG and GG genotypes for rs10757274 in CAD patients were 8.2, 58.3 and 33.5%, while in controls, the related values were 35, 63 and 2%, respectively. GG Genotype in rs10757274 polymorphism in CAD patients was found more than control cases (OR: 0.014, 95% CI: 0.003 -0.065, p=0.0001). Conclusion The rs1333049 polymorphism at 9p21 locus shows a weak association with CAD, whereas rs10757274 polymorphism reveals a significant association with CAD. These variants may help the identification of patients with increased risk for coronary artery disease. PMID:25870838

  17. Energy Star

    E-print Network

    Reihl, K.; Tullos, A.

    2012-01-01

    ENERGY STAR ENERGY TARGETS ESL-KT-12-10-08 CATEE 2012: Clean Air Through Energy Efficiency Conference, Galveston, TX, October 9-11, 2012 POP QUIZ!!!! What is EUI?? Energy Use Intensity Do you know the EUI and any of the buildings you designed... submit anytime before earn utility bills ? Project Types ? Commercial buildings (office, schools, hotels, banks, courthouses, warehouses, big box retail, etc.) ? Target Finder ? Achieve an EPA rating of 75 or greater ? Submit two documents 1...

  18. Christmas star.

    NASA Astrophysics Data System (ADS)

    Bia?a, J.

    There are continuous attempts to identify the legendary Christmas Star with a real astronomical event accompanying the birth of Jesus from Nazareth. Unfortunately, the date of birth is difficult to establish on the basis of historical records with better accuracy than a few years. During that period a number of peculiar astronomical events were observed and it seem to be impossible to identify the right one unambiguously.

  19. Consideration and checkboxes: incorporating ethics and science into the 3Rs.

    PubMed

    Landi, Margaret S; Shriver, Adam J; Mueller, Anne

    2015-03-01

    Members of the research community aim to both produce high-quality research and ensure that harm is minimized in animals. The primary means of ensuring these goals are both met is the 3Rs framework of replacement, reduction, and refinement. However, some approaches to the 3Rs may result in a 'check box mentality' in which IACUC members, researchers, administrators, and caretakers check off a list of tasks to evaluate a protocol. We provide reasons for thinking that the 3Rs approach could be enhanced with more explicit discussion of the ethical assumptions used to arrive at an approved research protocol during IACUC review. Here we suggest that the notion of moral considerability, and all of the related issues it gives rise to, should be incorporated into IACUC discussions of 3Rs deliberations during protocol review to ensure that animal wellbeing is enhanced within the constraints of scientific investigation. PMID:25836970

  20. MAPT1 gene rs1052553 variant is unrelated with the risk for restless legs syndrome.

    PubMed

    Roco, Angela; Jiménez-Jiménez, Félix Javier; Alonso-Navarro, Hortensia; Martínez, Carmen; Zurdo, Martín; Turpín-Fenoll, Laura; Millán, Jorge; Adeva-Bartolomé, Teresa; Cubo, Esther; Navacerrada, Francisco; Rojo-Sebastián, Ana; Rubio, Lluisa; Calleja, Marisol; Plaza-Nieto, José Francisco; Pilo-de-la-Fuente, Belén; Arroyo-Solera, Margarita; García-Martín, Elena; Agúndez, José A G

    2013-03-01

    Mutations in the microtubule-associated protein tau gene (MAPT) can cause frontotemporal dementia with Parkinsonism linked to the chromosome 17, and are associated with the risk for progressive supranuclear palsy, Parkinson's disease, corticobasal degeneration, and multiple system atrophy. We tried to establish, whether MAPT H1 discriminating haplotype single nucleotide polymorphisms (SNP) (rs1052553) is associated with the risk for restless legs syndrome (RLS). We studied the allelic and genotype frequencies of the SNP rs1052553 in 205 patients with RLS and 324 healthy controls using TaqMan genotyping. rs1052553 genotype and allelic frequencies did not differ significantly between patients with RLS and controls, and were unrelated with the age at onset of RLS, gender, family history of RLS, and severity of RLS. The results of the present study suggest that the SNP rs1052553 is not related with the risk for RLS. PMID:23001634

  1. Line profile asymmetries in chromospherically active stars

    NASA Technical Reports Server (NTRS)

    Dempsey, Robert C.; Bopp, Bernard W.; Strassmeier, Klaus G.; Granados, Arno F.; Henry, Gregory W.; Hall, Douglas S.

    1992-01-01

    A powerful, new probe of chromospheric activity, cross-correlation, has been developed and applied to a variety of stars. In this particular application, an entire CCD spectrum of an active star is correlated with the spectrum of a narrow-line, inactive star of similar spectral type and luminosity class. Using a number of strong lines in this manner enables the detection of absorption profile asymmetries at moderate resolution (lambda/Delta lambda about 40,000) and S/N 150:1. This technique has been applied to 14 systems mostly RS CVn's, with 10 not greater than nu sin i not greater than 50 km/s and P not less than 7 d. Distortions were detected for the first time in five systems: Sigma Gem, IM Peg, GX Lib, UV Crb, and Zeta And. Detailed modeling, incorporating both spectral line profiles and broad-band photometry, is applied to Sigma Gem. Profile asymmetries for this star are fitted by two high-latitude spots covering 5 percent of the stellar surface. The derived spot temperature of 3400 K is lower than found in previous studies. In addition, two well-known systems have been studied: HD 199178 and V711 Tau. Polar spots are found on both.

  2. A Reed-Solomon Product-Code (RS-PC) decoder for DVD applications

    Microsoft Academic Search

    H. C. Chang; C. Shung

    1998-01-01

    The digital versatile disk (DVD), an emerging standard of optical storage, provides a higher capacity than audio CD, CD-ROM or video CD (VCD). To mitigate the errors introduced during manufacturing or by user damage, a Reed-Solomon Product-Code (RS-PC) is used in DVD for error correction. For this application, the authors present an RS-PC decoder chip with a dual-frame-buffer architecture. The

  3. MEM for arbitrary closed queueing networks with RS-blocking and multiple job classes

    Microsoft Academic Search

    Demetres D. Kouvatsos; Irfan-Ullah Awan

    1998-01-01

    A new product-form approximation, based on the method of entropy maximisation (MEM), is characterised for arbitrary closed queueing networks with multiple and distinct classes of jobs, Generalised Exponential (GE) service times, mixed service disciplines, complete buffer sharing and repetitive-service blocking with both fixed (RS-FD) and random destinations (RS-RD). The maximum entropy (ME) approximation implies decomposition of the network into individual

  4. A lack of association between the IKZF2 rs12619285 polymorphism and coronary heart disease

    PubMed Central

    YE, HUADAN; HONG, QINGXIAO; LI, YIRUN; XU, XUTING; HUANG, YI; XU, LIMIN; ZHOU, ANNAN; DENG, YOUPING; DUAN, SHIWEI

    2015-01-01

    The IKZF2 rs12619285 polymorphism is associated with the eosinophil count, which has multidimensional functions in the pathogenesis of coronary heart disease (CHD). The aim of the present study was to investigate the contribution of the IKZF2 rs12619285 polymorphism to the risk of CHD in a Han Chinese population. In total, 721 CHD cases and 631 non-CHD controls were recruited for an association study of the IKZF2 rs12619285 polymorphism. Genotyping was performed using the melting temperature-shift polymerase chain reaction method. No statistically significant association was observed between the IKZF2 rs12619285 polymorphism and CHD (odds ratio, 1.139, 95% confidence interval, 0.927–1.334; P=0.17). In addition, subgroup analyses by gender or age were unable to identify any association between IKZF2 rs12619285 and CHD (P>0.05), and there was no significant correlation between IKZF2 rs12619285 and the severity of CHD (P>0.05). The power of the case-control study was determined to be 63.3%. In addition, the G allele frequency was calculated as 63.6% in the Han Chinese population, which was similar to the 59.3% recorded for the HapMap Chinese population of Han Chinese individuals living in Beijing, compared with 24.3% in European descendents (HapMap-CEU). Therefore, the results indicated that the IKZF2 rs12619285 polymorphism was not associated with CHD in a Han Chinese population. The discrepancy in the association between rs12619285 and CHD may be due to the ethnic differences between Han Chinese and European populations. PMID:25780427

  5. The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing

    Microsoft Academic Search

    P. D. Pharoah; R. T. Palmieri; S. J. Ramus; S. A. Gayther; I. L. Andrulis; H. Anton-Culver; N. Antonenkova; A. C. Antoniou; D. Goldgar; M. S. Beattie; M. W. Beckmann; M. J. Birrer; N. Bogdanova; K. L. Bolton; W. Brewster; A. Brooks-Wilson; R. Brown; R. Butzow; T. Caldes; M. A. Caligo; I. Campbell; J. Chang-Claude; Y. A. Chen; L. S. Cook; F. J. Couch; D. W Cramer; J. M. Cunningham; E. Despierre; J. A. Doherty; T. Dork; M. Durst; D. M. Eccles; A. B. Ekici; D. Easton; P. A. Fasching; A. de Fazio; D. A. Fenstermacher; J. M. Flanagan; B. L. Fridley; E. Friedman; B. Gao; O. Sinilnikova; A. Gentry-Maharaj; A. K. Godwin; E. L. Goode; M. T. Goodman; J. Gross; T. V. Hansen; P. Harnett; M. Rookus; T. Heikkinen; R. Hein; C. Hogdall; E. Hogdall; E. S. Iversen; A. Jakubowska; S. E. Johnatty; B. Y. Karlan; N. D. Kauff; S. B. Kaye; G. Chenevix-Trench; L. E. Kelemen; L. A. L. M. Kiemeney; S. K. Kjaer; D. Lambrechts; J. P. Lapolla; C. Lazaro; N. D. Le; A. Leminen; K. Leunen; D. A. Levine; Y. Lu; L. Lundvall; S. MacGregor; T. Marees; L. F. A. G. Massuger; J. R. McLaughlin; U. Menon; M. Montagna; K. B. Moysich; S. A. Narod; K. L. Nathanson; L. Nedergaard; R. B. Ness; H. Nevanlinna; S. Nickels; A. Osorio; J. Paul; C. L. Pearce; C. M. Phelan; M. C. Pike; P. Radice; M. A. Rossing; J. M. Schildkraut; T. A. Sellers; C. F. Singer; H. Song; D. O. Stram; R. Sutphen; A. Lindblom

    2011-01-01

    PURPOSE: An assay for the single-nucleotide polymorphism (SNP), rs61764370, has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'-UTR miRNA binding site of the KRAS oncogene and is a candidate for epithelial ovarian cancer (EOC) susceptibility. However, only one published article, analyzing

  6. The equivalence between B-W and K-G and R-S equations

    NASA Astrophysics Data System (ADS)

    Huang, Shi-Zhong; Ruan, Tu-Nan; Wu, Ning; Zheng, Zhi-Peng

    2003-01-01

    The equivalence between the Bargmann-Wigner (B-W) equations and the Klein-Gordon (K-G) equations for integral spin and the Rarita-Schwinger (R-S) equations for half integral spin is established by explicit derivation, starting from the lowest spin cases. It is demonstrated that all the constraints or subsidiary conditions imposed on the K-G or R-S equations are included in the B-W equations.

  7. Blind prediction test of free energies of hydration with COSMO-RS

    Microsoft Academic Search

    Andreas Klamt; Michael Diedenhofen

    2010-01-01

    The COSMO-RS method, a combination of the quantum chemical dielectric continuum solvation model COSMO with COSMO-RS, a statistical\\u000a thermodynamics treatment of surface interactions, simulations, has been used for the direct, blind prediction of free energies\\u000a of hydration within the SAMPL challenge. Straight application of the latest version of the COSMOtherm implementation in combination with a rigorous conformational sampling yielded a

  8. PCLO rs2522833 impacts HPA system activity in healthy young adults.

    PubMed

    Kuehner, C; Huffziger, S; Witt, S H; Rietschel, M

    2011-01-01

    Recent genetic studies showed evidence for a role of the single-nucleotide polymorphism rs2522833 within the PCLO gene in the etiology of major depression, and rs2522833 has been shown to modulate hypothalamic pituitary adrenal (HPA) axis activity during antidepressant treatment. Monoaminergic modulation of the HPA system may be one possible pathomechanism by which PCLO exerts its effect on depression. In the present study, we investigated the effect of rs2522833 on the cortisol awakening response (CAR) in healthy young adults. A total of 66 healthy volunteers from the community (36 men and 30 women) aged 18-25 years without individual or family history of affective disorders and schizophrenia collected saliva cortisol samples at 0, 30, 45 and 60?min after awakening on two consecutive working days. We identified a blunted CAR (AUCinc) in rs2522833 risk-allele (C) carriers, possibly indicating exhausted regulatory mechanisms underlying the HPA system. We also identified higher neuroticism scores in rs2522833 risk-allele carriers but no phenotypic correlation between the CAR (AUCinc) and neuroticism. These findings suggest that the rs2522833 risk variant might increase vulnerability to depression both by physiological and behavioral pathways, which appear, however, not to be substantially overlapped. Replication with larger samples is warranted. PMID:22832399

  9. Quantitative assessment of the association between AXIN2 rs2240308 polymorphism and cancer risk

    PubMed Central

    Gong, Juan; Jiang, Yuan; Hao, Ningbo; Zhu, Bo; Li, Yongsheng

    2015-01-01

    Axin2 is involved in the regulation of Wnt/?-catenin pathway and implicated in cancer development and progression. The association between AXIN2 rs2240308 polymorphism and cancer risk has been examined in several case-control studies, but the conclusions were conflicting. Here we performed a meta-analysis to evaluate the role of rs2240308 in cancer risk. A total of 8 studies were included in this meta-analysis (1559 cancer cases and 1503 controls). The pooled odds ratios (OR) and the 95% confidence intervals (CIs) were assessed to evaluate the association of the AXIN2 rs2240308 polymorphism with a susceptibility to cancer. A significantly decreased overall cancer risk was observed in the homozygous (TT vs. CC), heterozygous (CT vs. CC), dominant (CT+TT vs. CC) and allelic (T vs. C) models (P?rs2240308 was also associated with decreased cancer risk under all five models in lung cancer. However, AXIN2 rs2240308 polymorphism was not associated with cancer risk under any above model in Turkish population and under homozygous, heterozygous, recessive models in Japanese population. These findings indicate that AXIN2 rs2240308 polymorphism significantly and race-specifically correlates with decreased cancer risk. PMID:25974148

  10. Staphylococcus aureus Nuclease Is an SaeRS-Dependent Virulence Factor

    PubMed Central

    Olson, Michael E.; Nygaard, Tyler K.; Ackermann, Laynez; Watkins, Robert L.; Zurek, Oliwia W.; Pallister, Kyler B.; Griffith, Shannon; Kiedrowski, Megan R.; Flack, Caralyn E.; Kavanaugh, Jeffrey S.; Kreiswirth, Barry N.

    2013-01-01

    Several prominent bacterial pathogens secrete nuclease (Nuc) enzymes that have an important role in combating the host immune response. Early studies of Staphylococcus aureus Nuc attributed its regulation to the agr quorum-sensing system. However, recent microarray data have indicated that nuc is under the control of the SaeRS two-component system, which is a major regulator of S. aureus virulence determinants. Here we report that the nuc gene is directly controlled by the SaeRS two-component system through reporter fusion, immunoblotting, Nuc activity measurements, promoter mapping, and binding studies, and additionally, we were unable identify a notable regulatory link to the agr system. The observed SaeRS-dependent regulation was conserved across a wide spectrum of representative S. aureus isolates. Moreover, with community-associated methicillin-resistant S. aureus (CA MRSA) in a mouse model of peritonitis, we observed in vivo expression of Nuc activity in an SaeRS-dependent manner and determined that Nuc is a virulence factor that is important for in vivo survival, confirming the enzyme's role as a contributor to invasive disease. Finally, natural polymorphisms were identified in the SaeRS proteins, one of which was linked to Nuc regulation in a CA MRSA USA300 endocarditis isolate. Altogether, our findings demonstrate that Nuc is an important S. aureus virulence factor and part of the SaeRS regulon. PMID:23381999

  11. Single nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma

    PubMed Central

    Greenberg, Alexandra J.; Lee, Adam M.; Serie, Daniel J.; McDonnell, Shannon K.; Cerhan, James R.; Liebow, Mark; Larson, Dirk R.; Colby, Colin L.; Norman, Aaron D.; Kyle, Robert A.; Rajkumar, S. Vincent; Diasio, Robert B.; Slager, Susan L.; Vachon, Celine M.

    2013-01-01

    Summary Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant precursor to multiple myeloma (MM). Though several genetic variants have been identified for MM, none have been identified for MGUS. Recently, Broderick et al. conducted a GWAS of MM and identified three novel loci at 3p22.1 (rs1052501), 7p15.3 (rs4487645) and 2p23.3 (rs6746082) associated with MM risk. We examined the association of these variants with MGUS in a clinic-based case-control study of 391 MGUS cases and 365 controls. We also attempted to replicate the reported association with MM (243 MM cases, 365 controls). We found rs1052501 associated with increased risk of both MGUS (OR=1.32; 95% CI, 1.02 to 1.72; p=0.04) and MM (OR=1.39; 95% CI, 1.04, 1.86; p=0.03). However, there were no associations with the other two loci, rs6746082 and rs4487645, for either MGUS or MM. We identified one genetic variant that may exert its influence on MM through its association with MGUS. PMID:22945773

  12. CYP17 polymorphism (rs743572) is associated with increased risk of gallbladder cancer in tobacco users.

    PubMed

    Rai, Rajani; Sharma, Kiran L; Misra, Sanjeev; Kumar, Ashok; Mittal, Balraj

    2014-07-01

    Gallbladder cancer (GBC) involves interplay of sex steroids, including estrogen and progesterone. Since CYP17 is a key enzyme involved in estrogen and testosterone hormone biosynthesis as well as in xenobiotic metabolism, it may be a potential candidate gene in the carcinogenesis of the gallbladder. Hence, the present study aimed to investigate the association of CYP17 (rs2486758, and rs743572) polymorphisms with GBC susceptibility. The present study included a total of 414 histologically confirmed GBC and 230 healthy controls. The CYP17 (rs2486758 and rs743572) polymorphisms were genotyped by TaqMan-Allele discrimination assays. Statistical analysis was performed by using SPSS ver. 16. Overall, both the CYP17 SNPs did not indicate any association with GBC risk at genotype, haplotype, or at the genotypic interaction levels. However, in the case-only analysis, CYP rs743572 showed association with increased risk of GBC in tobacco users at hetero genotype and dominant models, as compared to non-user GBC patients. The TCrs2486758-AGrs743572 genotypic combination was also associated with increased GBC susceptibility in tobacco users. CYP17 rs743572 is associated with increased risk of GBC in tobacco users in the North Indian population. However, the study requires confirmation in other populations. PMID:24687554

  13. Association between the rs342293 polymorphism and adverse cardiac events in patients undergoing percutaneous coronary intervention.

    PubMed

    Siller-Matula, Jolanta M; Arbesu, Iciar; Jilma, Bernd; Maurer, Gerald; Lang, Irene M; Mannhalter, Christine

    2014-06-01

    The single nucleotide polymorphism (SNP) rs342293 has been shown to influence platelet number and mean platelet volume (MPV). We investigated the association between the rs342293 polymorphism and cardiovascular outcome in a prospective cohort study. The rs342293 polymorphism was analysed in 404 patients with coronary artery disease undergoing percutaneous coronary intervention. The rates of cardiac adverse events were recorded during two years of follow-up. The polymorphism was associated with MPV (median 10.1 fL, interquartile range [IQR]: 9.6 to 10.6 in patients with the CC-allele vs 10.4 fL, IQR: 9.9 to 11.1 in G>C SNP carriers; p<0.001), but not with platelet count. Survival analysis indicated that carriers of the rs342293 G variant had a substantially higher risk to develop cardiac adverse events compared with wild type carriers during two years of follow-up (33% vs 22%; adjusted hazard ratio = 1.63, 95% confidence interval = 1.06-2.52, p=0.027). The rs342293 SNP could explain 2.9% of the variability in MPV (p=0.01). In conclusion, patients undergoing coronary stenting who carry the G-variant of the rs342293 SNP which is associated with larger MPV are at higher risk for adverse cardiovascular outcome. PMID:24652536

  14. New insights into the dust formation of oxygen-rich AGB stars

    NASA Astrophysics Data System (ADS)

    Karovicova, I.; Wittkowski, M.; Ohnaka, K.; Boboltz, D. A.; Fossat, E.; Scholz, M.

    2013-12-01

    Context. Asymptotic giant branch (AGB) stars are one of the major sources of dust in the universe. The formation of molecules and dust grains and their subsequent expulsion into the interstellar medium via strong stellar winds is under intense investigation. This is in particular true for oxygen-rich stars, for which the path of dust formation has remained unclear. Aims: We conducted spatially and spectrally resolved mid-infrared multi-epoch interferometric observations to investigate the dust formation process in the extended atmospheres of oxygen-rich AGB stars. Methods: We observed the Mira variable AGB stars S Ori, GX Mon, and R Cnc between February 2006 and March 2009 with the MIDI instrument at the VLT interferometer. We compared the data to radiative transfer models of the dust shells, where the central stellar intensity profiles were described by dust-free dynamic model atmospheres. We used Al2O3 and warm silicate grains, following earlier studies in the literature. Results: Our S Ori and R Cnc data could be well described by an Al2O3 dust shell alone, and our GX Mon data by a mix of an Al2O3 and a silicate shell. The best-fit parameters for S Ori and R Cnc included photospheric angular diameters ?Phot of 9.7 ± 1.0 mas and 12.3 ± 1.0 mas, optical depths ?V(Al2O3) of 1.5 ± 0.5 and 1.35 ± 0.2, and inner radii Rin of 1.9 ± 0.3 RPhot and 2.2 ± 0.3 RPhot, respectively. Best-fit parameters for GX Mon were ?Phot = 8.7 ± 1.3 mas, ?V(Al2O3) = 1.9 ± 0.6, Rin(Al2O3) = 2.1 ± 0.3 RPhot, ?V(silicate)= 3.2 ± 0.5, and Rin(silicate)= 4.6 ± 0.2 RPhot. Our data did not show evidence of intra-cycle and cycle-to-cycle variability or of asymmetries within the error-bars and within the limits of our baseline and phase coverage. Conclusions: Our model fits constrain the chemical composition and the inner boundary radii of the dust shells, as well as the photospheric angular diameters. Our interferometric results are consistent with Al2O3 grains condensing close to the stellar surface at about 2 stellar radii, co-located with the extended atmosphere and SiO maser emission, and warm silicate grains at larger distances of about 4-5 stellar radii. We verified that the number densities of aluminum can match that of the best-fit Al2O3 dust shell near the inner dust radius in sufficiently extended atmospheres, confirming that Al2O3 grains can be seed particles for the further dust condensation. Together with literature data of the mass-loss rates, our sample is consistent with a hypothesis that stars with low mass-loss rates form primarily dust that preserves the spectral properties of Al2O3, and stars with higher mass-loss rate form dust with properties of warm silicates. Based on observations made with the Very Large Telescope Interferometer (VLTI) at the Paranal Observatory under program IDs 073.D-0711, 075.D-0097, 077.D-0630, 079.D-0172, and 082.D-0723.Tables 1-3, 8, 9 are available in electronic form at http://www.aanda.org

  15. Swift X-ray and ultraviolet observations of the shortest orbital period double-degenerate system RX J0806.3+1527 (HM Cnc)

    E-print Network

    Esposito, P; Dall'Osso, S; Covino, S

    2013-01-01

    RX J0806.3+1527 (HM Cnc) is a pulsating X-ray source with 100 per cent modulation on a period of 321.5 s (5.4 min). This period reflects the orbital motion of a close binary system consisting of two interacting white dwarfs. Here we present a series of simultaneous X-ray (0.2-10 keV) and near-ultraviolet (2600 angstrom and 1928 angstrom) observations carried out with the Swift satellite. In the near-ultraviolet the counterpart of RX J0806.3+1527 was detected at flux densities consistent with a blackbody with temperature 27E+3 K. We found that the emission at 2600 angstrom is modulated at the 321.5-s period, with the peak ahead of the X-ray one by 0.28 cycles and coincident, within 0.05 cycles, with the optical. This phase-shift measurement confirms that the X-ray hot spot (located on the primary white dwarf) is at about 80-100 degrees from the direction connecting the two white dwarfs. Albeit at lower significance, the 321.5-s signature is present also in the 1928-angstrom data; at this wavelength, however, t...

  16. Binary stars.

    PubMed

    Paczynacuteski, B

    1984-07-20

    Most stars in the solar neighborhood are either double or multiple systems. They provide a unique opportunity to measure stellar masses and radii and to study many interesting and important phenomena. The best candidates for black holes are compact massive components of two x-ray binaries: Cygnus X-1 and LMC X-3. The binary radio pulsar PSR 1913 + 16 provides the best available evidence for gravitational radiation. Accretion disks and jets observed in close binaries offer a very good testing ground for models of active galactic nuclei and quasars. PMID:17749544

  17. Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.

    PubMed

    Ou, Jingxing; Vijayasarathy, Camasamudram; Ziccardi, Lucia; Chen, Shan; Zeng, Yong; Marangoni, Dario; Pope, Jodie G; Bush, Ronald A; Wu, Zhijian; Li, Wei; Sieving, Paul A

    2015-07-01

    Strategies aimed at invoking synaptic plasticity have therapeutic potential for several neurological conditions. The human retinal synaptic disease X-linked retinoschisis (XLRS) is characterized by impaired visual signal transmission through the retina and progressive visual acuity loss, and mice lacking retinoschisin (RS1) recapitulate human disease. Here, we demonstrate that restoration of RS1 via retina-specific delivery of adeno-associated virus type 8-RS1 (AAV8-RS1) vector rescues molecular pathology at the photoreceptor-depolarizing bipolar cell (photoreceptor-DBC) synapse and restores function in adult Rs1-KO animals. Initial development of the photoreceptor-DBC synapse was normal in the Rs1-KO retina; however, the metabotropic glutamate receptor 6/transient receptor potential melastatin subfamily M member 1-signaling (mGluR6/TRPM1-signaling) cascade was not properly maintained. Specifically, the TRPM1 channel and G proteins G?o, G?5, and RGS11 were progressively lost from postsynaptic DBC dendritic tips, whereas the mGluR6 receptor and RGS7 maintained proper synaptic position. This postsynaptic disruption differed from other murine night-blindness models with an electronegative electroretinogram response, which is also characteristic of murine and human XLRS disease. Upon AAV8-RS1 gene transfer to the retina of adult XLRS mice, TRPM1 and the signaling molecules returned to their proper dendritic tip location, and the DBC resting membrane potential was restored. These findings provide insight into the molecular plasticity of a critical synapse in the visual system and demonstrate potential therapeutic avenues for some diseases involving synaptic pathology. PMID:26098217

  18. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

    PubMed Central

    Bonhaus, Douglas W; Flippin, Lee A; Greenhouse, Robert J; Jaime, Saul; Rocha, Cindy; Dawson, Mark; Van Natta, Kristine; Chang, L K; Pulido-Rios, Tess; Webber, Andrea; Leung, Edward; Eglen, Richard M; Martin, Graeme R

    1999-01-01

    Efforts to define precisely the role of 5-HT2B receptors in normal and disease processes have been hindered by the absence of selective antagonists. To address this deficiency, we developed a series of naphthylpyrimidines as potentially useful 5-HT2B receptor antagonists. RS-127445 (2-amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine) was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5±0.1) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. In cells expressing human recombinant 5-HT2B receptors, RS-127445 potently antagonized 5-HT-evoked formation of inositol phosphates (pKB=9.5±0.1) and 5-HT-evoked increases in intracellular calcium (pIC50=10.4±0.1). RS-127445 also blocked 5-HT-evoked contraction of rat isolated stomach fundus (pA2=9.5±1.1) and (±)?-methyl-5-HT-mediated relaxation of the rat jugular vein (pA2=9.9±0.3). RS-127445 had no detectable intrinsic activity in these assays. In rats, the fraction of RS-127445 that was bioavailable via the oral or intraperitoneal routes was 14 and 60% respectively. Intraperitoneal administration of RS-127445 (5?mg?kg?1) produced plasma concentrations predicted to fully saturate accessible 5-HT2B receptors for at least 4?h. In conclusion, RS-127445 is a selective, high affinity 5-HT2B receptor antagonist suitable for use in vivo. The therapeutic potential of this molecule is being further evaluated. PMID:10455251

  19. RS-25 for the NASA Crew Launch Vehicle: The Evolution of SSME for Space Exploration

    NASA Technical Reports Server (NTRS)

    Kynard, Michael H.; Genge, Gary G.; Greene, William D.; Jacobs, William; McArthur, J. Craig; Mims, Michael J.; Tepool, J. Eric; Wofford, Steven J.

    2006-01-01

    As a first step towards the fulfillment of the National Vision for Space Exploration, NASA has begun development of the Crew Launch Vehicle (CLV). The CLV will act, in conjunction with the Crew Exploration Vehicle, as the next generation human launch system to first support missions to the International Space Station (ISS), then later to support the lunar return missions, and then after that to exploration missions to Mars and beyond. The CLV is a two-stage launch vehicle with the first stage based upon the Space Shuttle solid rocket booster. The newly designed, expendable second stage is powered by a single RS-25 liquid hydrogen/liquid oxygen rocket engine. The RS-25 is essentially the Space Shuttle Main Engine (SSME) evolved for a new mission, new environments, and new conditions. The CLV Upper-Stage Engine (USE) office has been established to develop the RS-25 in support of the CLV Project. This paper presents an outline and discussion of the risks associated with this endeavor of transforming the SSME into the upper-stage, altitude-start RS-25 and the plans being undertaken to understand and mitigate these risks. In addition, to meet the long-term requirements of the CLV launch manifest, it will be necessary to redevelop the RS-25, with its long history as the reusable SSME for the Space Shuttle Program, as an expendable engine. While the first flights of CLV will be using heritage SSME hardware, beyond that a new version of RS-25 as an expendable engine is being pursued by the CLV USE element. The goals of this work include the need to make the hardware more producible while maintaining the inherent and inherited reliability of the basic design. This paper will also discuss the risks and present the plans for developing both this next generation version of the RS-25 and for developing the manufacturing capacity necessary to support the CLV Project.

  20. Evidence of mechanism how rs7575840 influences apolipoprotein B containing lipid particles

    PubMed Central

    Haas, Blake E.; Weissglas-Volkov, Daphna; Aguilar-Salinas, Carlos A.; Nikkola, Elina; Vergnes, Laurent; Cruz-Bautista, Ivette; Riba, Laura; Stancakova, Alena; Kuusisto, Johanna; Soininen, Pasi; Kangas, Antti J.; Ala-Korpela, Mika; Tusie-Luna, Teresa; Laakso, Markku; Pajukanta, Päivi

    2011-01-01

    Objective Recent genome-wide association studies (GWAS) identified a variant rs7575840 in the apolipoprotein B (APOB) gene region to be associated with LDL-C. However, the underlying functional mechanism of this variant that resides 6.5 kb upstream of APOB has remained unknown. Our objective was to investigate rs7575840 for association with refined apoB containing lipid particles; for replication in a non-Caucasian Mexican population; and for underlying functional mechanism. Methods and Results Our data show that rs7575840 is associated with serum apoB levels (P=4.85×10?10) and apoB containing lipid particles, very small VLDL, IDL and LDL particles (P=2×10?5 - 9×10?7) in the Finnish METSIM study sample (n=7,710). Fine mapping of the APOB region using 43 SNPs replicated the association of rs7575840 with apoB in a Mexican study sample (n=2,666, P=3.33×10?05). Furthermore, our transcript analyses of adipose RNA samples from 175 Finnish METSIM subjects indicate that rs7575840 alters expression of APOB (P=1.13×10?10) and a regional non-coding RNA (BU630349) (P=7.86×10?6) in adipose tissue. Conclusions It has been difficult to convert GWAS associations into mechanistic insights. Our data show that rs7575840 is associated with serum apoB levels and apoB containing lipid particles as well as influences expression of APOB and a regional transcript BU630349 in adipose tissue. We thus provide evidence how a common genome-wide significant SNP rs7575840 may affect serum apoB, LDL-C, and TC levels. PMID:21393584

  1. First 2.2 micrometer results from the iota interferometer

    NASA Technical Reports Server (NTRS)

    Dyck, H. M.; Benson, J. A.; Carlton, N. P.; Coldwell, C.; Lacasse, M. G.; Nisenson, P.; Panasyuk, A.; Papaliolios, C.; Pearlman, R. D.; Reasenberg, R. D.

    1995-01-01

    We present the first infrared fringe visibility measurements made with the Infrared Optical Telescope Array on Mt. Hopkins. Effective temperatures are derived for RX Boo, RS Cnc, and Beta Peg. RX Boo is the coolest small-amplitude variable giant star to have an effective temperature determination. We compare the size of its photosphere at infrared wavelengths with the sizes of its SiO and H20 radio emission regions. We also discuss initial performance parameters for the interferometer.

  2. Composite spectra: XX. 45 Cancri. Two stars with very similar masses but quite different evolutionary states

    NASA Astrophysics Data System (ADS)

    Griffin, R. E. M.; Griffin, R. F.

    2015-02-01

    From accurate radial-velocity measurements covering 11 circuits of the orbit of the composite-spectrum binary 45 Cnc, together with high-resolution spectroscopy spanning nearly 3 circuits, we have (i) isolated cleanly the spectrum of the early-type secondary, (ii) classified the component spectra as G8 III and A3 III, (iii) derived the first double-lined orbit for the system and a mass ratio (M_1/M_2) of 1.035 ± 0.01, and (iv) extracted physical parameters for the component stars, deriving the masses and (log) luminosities of the G star and A star as 3.11 and 3.00 M?} R?, and 2.34 and 2.28 L?, respectively, with corresponding uncertainties of ±0.10 M? R? and ±0.09 L?. Since the mass ratio is close to unity, we argue that the more evolved component is unlikely to have been a red giant long enough to have made multiple ascents of the RGB, an argument that is supported somewhat by the rather high eccentricity of the orbit (e = 0.46) and the evolutionary time-scales of the two components, but chiefly by the presence of significant Li I in the spectrum of the cool giant.

  3. Spectroscopic Binary Star Studies with the Palomar Testbed Interferometer II

    E-print Network

    for which we will present new orbit mod- els are: 12 Boo (HD 123999), 75 Cnc (HD 78418), 47 And (HD 8374.4 1.6 27.1 #6; 0.4 27.3 #6; 0.8 BY Dra K6 V 4.4 24 65.8 #6; 5.4 60.9 #6; 0.9 75 Cnc G5 IV 5.9 4.6 31 completed our analysis or have solid provisional solutions: 12 Boo (HD 123999), 75 Cnc (HD 78418), 47

  4. Effects of PSCA rs2294008 (C/T) and c-MYC rs9642880 (G/T) polymorphisms on bladder cancer: evidence from a meta-analysis

    PubMed Central

    Gao, Jie; Yang, Peng-Tao; Diao, Yan; Kang, Hua-Feng; Zhao, Yang; Lin, Shuai; Wang, Zi-Ming; Wang, Meng; Wang, Xi-Jing; Dai, Zhi-Jun

    2015-01-01

    Previous studies have investigated the associations between the two polymorphisms (prostate stem cell antigen (PSCA) rs2294008 C/T and c-MYC rs9642880 G/T) and bladder cancer (BC) risk. However, the results are inconsistent. We therefore carried out a meta-analysis to estimate the relationship between PSCA/c-MYC polymorphisms and BC risk. We searched PubMed up to November 2014 to identify potentially eligible literatures. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of the associations, the data were further stratified by ethnicity. Heterogeneity was evaluated by Q test and I2 statistics. Begg’s funnel plot and Egger’s test were used to assess the publication bias. 11 studies from 9 articles were identified, including a total of 16,814 cancer cases and 52,868 case-free controls. We found a significant association between PSCA rs2294008 polymorphism and BC risk (the allele contrast model: OR = 1.14, 95% CI = 1.11-1.18; homozygote comparison: OR = 1.28, 95% CI = 1.20-1.37; heterozygote comparison: OR = 1.23, 95% CI = 1.17-1.30; dominant model: OR = 1.25, 95% CI = 1.19-1.31 and recessive model: OR = 1.13, 95% CI = 1.07-1.20). Moreover, a significant increased risk of BC was confirmed both in Caucasian and in Asians. For c-MYC rs9642880 polymorphism, significant increased BC risk was detected under the following genetic models (the allele contrast model: OR = 1.20, 95% CI = 1.13-1.27; homozygote comparison: OR = 1.37, 95% CI = 1.21-1.55; heterozygote comparison: OR = 1.20, 95% CI = 1.09-1.32; dominant model: OR = 1.25, 95% CI = 1.14-1.37 and recessive model: OR = 1.26, 95% CI = 1.13-1.40). Further stratified analysis by ethnicity also observed the same results. This meta-analysis suggested that PSCA rs2294008 and c-MYC rs9642880 polymorphisms may increase the BC risk. Further studies are needed to clarify the effects. PMID:25932146

  5. Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta-analysis.

    PubMed

    Zeng, Xian-Tao; Lu, Jun-Ti; Tang, Xiang-Jun; Weng, Hong; Luo, Jie

    2014-05-01

    Several epidemiological studies suggested that methionine synthase (MTRR) rs1801394 and methionine synthase reductase (MTR) rs1805087 polymorphisms may be involved in the risk of meningioma in adults; however, the results from different case-control studies have been inconsistent. Therefore, we performed a meta-analysis to investigate the association of MTRR and MTR polymorphisms with meningioma. PubMed, Web of Knowledge, China National Knowledge Infrastructure and Wanfang databases were searched up to October 30, 2013 and 3 publications, involving 7 case-control studies, were finally included. Following data extraction, a meta-analysis was conducted using Stata 12.0 software. The pooled results based on the fixed effects model demonstrated that the MTRR rs1801394 polymorphism was associated with an increased risk of meningioma [odds ratio (OR)=1.18, 95% confidence interval (CI): 1.05-1.32 for G vs. A; OR=1.41, 95% CI: 1.12-1.77 for GG vs. AA; OR=1.08, 95% CI: 0.94-1.33 for AG vs. AA; OR=1.19, 95% CI: 1.01-1.40 for (AG+GG) vs. AA; and OR=1.32, 95% CI: 1.07-1.63 for GG vs. (AG+AA)]; however, an association between the MTR rs1805087 polymorphism and the risk of meningioma was not identified [OR=0.99, 95% CI: 0.88-1.12 for G vs. A; OR=1.09, 95% CI: 0.80-1.48 for GG vs. AA; OR=0.95, 95% CI: 0.82-1.11 for AG vs. AA; OR=0.97, 95% CI: 0.84-1.13 for (AG+GG) vs. AA; and OR=1.09, 95% CI: 0.80-1.48 for GG vs. (AG+AA)]. Therefore, the currently available evidence suggests that the MTRR rs1801394 polymorphism may increase the risk of meningioma, whereas the MTRR rs1801394 polymorphism is not associated with meningioma. PMID:24748989

  6. FIRE, A Test Bed for ARIES-RS/AT Advanced Physics and Plasma Technology

    SciTech Connect

    Dale M. Meade

    2004-10-21

    The overall vision for FIRE [Fusion Ignition Research Experiment] is to develop and test the fusion plasma physics and plasma technologies needed to realize capabilities of the ARIES-RS/AT power plant designs. The mission of FIRE is to attain, explore, understand and optimize a fusion dominated plasma which would be satisfied by producing D-T [deuterium-tritium] fusion plasmas with nominal fusion gains {approx}10, self-driven currents of {approx}80%, fusion power {approx}150-300 MW, and pulse lengths up to 40 s. Achieving these goals will require the deployment of several key fusion technologies under conditions approaching those of ARIES-RS/AT. The FIRE plasma configuration with strong plasma shaping, a double null pumped divertor and all metal plasma-facing components is a 40% scale model of the ARIES-RS/AT plasma configuration. ''Steady-state'' advanced tokamak modes in FIRE with high beta, high bootstrap fraction, and 100% noninductive current drive are suitable for testing the physics of the ARIES-RS/A T operating modes. The development of techniques to handle power plant relevant exhaust power while maintaining low tritium inventory is a major objective for a burning plasma experiment. The FIRE high-confinement modes and AT-modes result in fusion power densities from 3-10 MWm{sup -3} and neutron wall loading from 2-4 MWm{sup -2} which are at the levels expected from the ARIES-RS/AT design studies.

  7. NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis

    PubMed Central

    2014-01-01

    Background A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population. Methods We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays. Results NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS. Conclusions Our results indicate that NQO1 rs1800566 does not have an effect on MS disease risk. PMID:24755231

  8. No Expanding Fireball: Resolving the Recurrent Nova RS Ophiuchi with Infrared Interferometry

    NASA Astrophysics Data System (ADS)

    Monnier, J. D.; Barry, R. K.; Traub, W. A.; Lane, B. F.; Akeson, R. L.; Ragland, S.; Schuller, P. A.; Le Coroller, H.; Berger, J.-P.; Millan-Gabet, R.; Pedretti, E.; Schloerb, F. P.; Koresko, C.; Carleton, N. P.; Lacasse, M. G.; Kern, P.; Malbet, F.; Perraut, K.; Kuchner, M. J.; Muterspaugh, M. W.

    2006-08-01

    Following the recent outburst of the recurrent nova RS Oph on 2006 February 12, we measured its near-infrared size using the IOTA, Keck, and PTI Interferometers at multiple epochs. The characteristic size of ~3 mas hardly changed over the first 60 days of the outburst, ruling out currently popular models whereby the near-infrared emission arises from hot gas in the expanding shock. The emission was also found to be significantly asymmetric, evidenced by nonzero closure phases detected by IOTA. The physical interpretation of these data depends strongly on the adopted distance to RS Oph. Our data can be interpreted as the first direct detection of the underlying RS Oph binary, lending support to the recent ``reborn red giant'' models of Hachisu & Kato. However, this result hinges on an RS Oph distance of <~540 pc, in strong disagreement with the widely adopted distance of ~1.6 kpc. At the farther distance, our observations imply instead the existence of a nonexpanding, dense, and ionized circumbinary gaseous disk or reservoir responsible for the bulk of the near-infrared emission. Longer baseline infrared interferometry is uniquely suited to distinguish between these models and to ultimately determine the distance, binary orbit, and component masses for RS Oph, one of the closest known (candidate) Type 1a supernova progenitor systems.

  9. Creation of unification RS and geophysical data in Central Kyzylkum-Western Uzbekistan

    NASA Astrophysics Data System (ADS)

    Sidorova, Elena

    2014-05-01

    In the report describes the state of the art of remote sensing and geophysical studies- seismic, magnetic data on the covered Mz-Kz deposits area of Central Kyzylkum. The complex data interpretation includes three steps: (i) creation geophysical data base in ArcGIS 10.1 software; (ii) processing RS data and Erdas Imagine 9.2 software (indication method, PCA analysis and etc.); (iii) integration geophysical and RS data in to ArcGIS&RS model. Materials of seismic and magnetic studies were used for the identification of anomalous objects and their heterogeneities in deep horizons of the consolidated crust as the basis for further correlation with RS data observed on the Earth's surface. As results of collaboration between GIS and RS data analysis the new prospect areas were extracted from the study areas. Were revealed the geological structures in 3-D model, associated with mineralization, lineaments and ring structures. The complex analysis of model allowed proposing new potential ore areas for statement of prospecting work. As example, we present results of correlation between Tamdy ring structure and high velocity object on the deep 4 km, which in the which also link with large gold deposit Muruntau in Central Kyzylkum.

  10. Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis

    PubMed Central

    Li, Jingguang; Zhao, Yajun; Li, Rena; Broster, Lucas S.; Zhou, Chenglin; Yang, Suyong

    2015-01-01

    A common variant in the oxytocin receptor gene (OXTR), rs53576, has been broadly linked to socially related personality traits and behaviors. However, the pattern of published results is inconsistent. Here, we performed a meta-analysis to comprehensively evaluate the association. The literature was searched for relevant studies and effect sizes between individuals homozygous for the G allele (GG) and individuals with A allele carriers (AA/AG). Specifically, two indices of sociality were evaluated independently: i) general sociality (24 samples, n = 4955), i.e., how an individual responds to other people in general; and ii) close relationships (15 samples, n = 5262), i.e., how an individual responds to individuals with closed connections (parent-child or romantic relationship). We found positive association between the rs53576 polymorphism and general sociality (Cohen’s d = 0.11, p = .02); G allele homozygotes had higher general sociality than the A allele carriers. However, the meta-analyses did not detect significant genetic association between rs53576 and close relationships (Cohen’s d = 0.01, p = .64). In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders. PMID:26121678

  11. The physiological target for LeuRS translational quality control is norvaline.

    PubMed

    Cvetesic, Nevena; Palencia, Andrés; Halasz, Ivan; Cusack, Stephen; Gruic-Sovulj, Ita

    2014-08-01

    The fidelity of protein synthesis depends on the capacity of aminoacyl-tRNA synthetases (AARSs) to couple only cognate amino acid-tRNA pairs. If amino acid selectivity is compromised, fidelity can be ensured by an inherent AARS editing activity that hydrolyses mischarged tRNAs. Here, we show that the editing activity of Escherichia coli leucyl-tRNA synthetase (EcLeuRS) is not required to prevent incorrect isoleucine incorporation. Rather, as shown by kinetic, structural and in vivo approaches, the prime biological function of LeuRS editing is to prevent mis-incorporation of the non-standard amino acid norvaline. This conclusion follows from a reassessment of the discriminatory power of LeuRS against isoleucine and the demonstration that a LeuRS editing-deficient E. coli strain grows normally in high concentrations of isoleucine but not under oxygen deprivation conditions when norvaline accumulates to substantial levels. Thus, AARS-based translational quality control is a key feature for bacterial adaptive response to oxygen deprivation. The non-essential role for editing under normal bacterial growth has important implications for the development of resistance to antimicrobial agents targeting the LeuRS editing site. PMID:24935946

  12. The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction

    PubMed Central

    CLARKE, TONI-KIM; WEISS, AMY R.D.; FERARRO, THOMAS N.; KAMPMAN, KYLE M.; DACKIS, CHARLES A.; PETTINATI, HELEN M.; O'BRIEN, CHARLES P.; OSLIN, DAVID W.; LOHOFF, FALK W.; BERRETTINI, WADE H.

    2014-01-01

    SUMMARY The risk for drug addiction is partially heritable. Genes of the dopamine system are likely candidates to harbor risk variants, as dopamine neurotransmission is involved in mediating the rewarding effects of drugs of abuse. One functional SNP in DRD2, rs1076560, is involved in regulating splicing of the gene and alters the ratio of DRD2 isoforms located pre and post-synaptically. rs1076560 has been previously associated with cocaine abuse and we set out to confirm this association in a sample of European American (n=336) and African American (n=1034) cocaine addicts and European American (n=656) and African American (n=668) controls. We also analysed the role of rs1076560 in opioid dependence by genotyping European American (n=1041) and African American (n=284) opioid addicts. rs1076560 was found to be nominally associated with opioid dependence in European Americans (p=0.02, OR=1.27) and African Americans (p=0.03, OR=1.43). When both opioid addicted ancestral samples were combined, rs1076560 was significantly associated with increased risk for drug dependence (p=0.0038, OR=1.29). This association remained significant after correction for multiple testing. No association was found with cocaine dependence. These data demonstrate the importance of dopamine gene variants in the risk for opioid dependence and highlight a functional polymorphism which warrants further study. PMID:24359476

  13. NUDT11 rs5945572 polymorphism and prostate cancer risk: a meta-analysis

    PubMed Central

    Li, Wencheng; Gu, Min

    2015-01-01

    The association between the NUDT10 rs5945572 polymorphism and prostate cancer (PCa) was not clear. We thus conducted a meta-analysis to assess the association between NUDT10 rs5945572 polymorphism and PCa risk. A literature search was carried out using PUBMED, EMBASE, and Cochrane Library Central database before Dec 2014. The strength of the associations between the NUDT10 rs5945572 polymorphism and PCa risk was measured by odds ratios (OR) with 95% confidence intervals (CI). The random-effects model was used. NUDT10 rs5945572 polymorphism was significantly associated with PCa risk (OR = 1.22, 95% CI 1.19-1.26, P < 0.001, I2 = 0%, Figure 2). In the subgroup analysis by ethnicity, a significant association was found among Caucasians (OR = 1.25, 95% CI 1.00-1.57, P = 0.05, I2 = 0%), and Asians (OR = 1.23, 95% CI 1.19-1.28, P < 0.001, I2 = 0%), and Africans (OR = 1.22, 95% CI 1.03-1.45, P = 0.02, I2 = 48%). In conclusion, this meta-analysis found a significant association between NUDT10 rs5945572 polymorphism and prostate cancer.

  14. An Evaluation of Association between a Novel Hippocampal Biology Related SNP (rs7294919) and Schizophrenia

    PubMed Central

    Liu, Jiewei; Numata, Shusuke; Ikeda, Masashi; Watanabe, Yuichiro; Zheng, Xue-bin; Luo, Xiongjian; Kinoshita, Makoto; Nunokawa, Ayako; Someya, Toshiyuki; Ohmori, Tetsuro; Bei, Jin-xin; Chong, Siow-Ann; Lee, Jimmy; Li, Zhiqiang; Liu, Jianjun; Iwata, Nakao; Shi, Yongyong; Li, Ming; Su, Bing

    2013-01-01

    Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N?=?3) and Japanese (N?=?3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p?=?0.51 in total samples, odds ratio?=?1.02 for allele[C]). The absence of rs7294919’s association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations. PMID:24278305

  15. CCDC26 rs4295627 polymorphism and glioma risk: a meta-analysis

    PubMed Central

    Cui, Tao

    2015-01-01

    Several studies have examined the association of CCDC26 rs4295627 polymorphism and glioma risk. However, the results were conflicting. Thus, a meta-analysis was conducted. We searched for relevant studies up to Dec 2014 in both English and Chinese through the PubMed/MEDLINE, EMBASE, the China National Knowledge Infrastructure (CNKI) platforms, WanFang and VIP database. Overall, 14 studies with 17419 cases and 28465 controls were selected for final meta-analysis. CCDC26 rs4295627 polymorphism was significantly associated with an increased risk of glioma (OR = 1.25, 95% CI 1.15-1.36, P < 0.00001). Interestingly, CCDC26 rs4295627 polymorphism might decrease the risk of glioma in Asians (OR = 0.92, 95% CI 0.82-1.03, P = 0.15). However, Caucasians with CCDC26 rs4295627 polymorphism showed an increased risk of glioma (OR = 1.33, 95% CI 1.25-1.46, P < 0.00001). Subgroup analysis was performed by histology. Significant associations were observed among astrocytoma patients (OR = 1.31, 95% CI 1.17-1.47, P < 0.00001) and oligodendroglioma patients (OR = 1.79, 95% CI 1.47-2.17, P < 0.00001). No significant association was found between this polymorphism and glioblastoma risk (OR = 0.11, 95% CI 0.92-1.33, P = 0.28). This meta-analysis suggested that CCDC26 rs4295627 polymorphism was a risk factor for glioma.

  16. Star Search

    NSDL National Science Digital Library

    2012-04-02

    In this online activity, learners can test their skills at finding constellations in the northern hemisphere's night sky. Learners can choose during which season to look, and then look for four constellations in that season. The simulation shows a simple representation of the night sky with key stars highlighted. Use this as a practice before going outside or just to give learners an idea of the difficulties involved in identifying constellations. When learners set up a free account at Kinetic City, they can answer bonus questions at the end of the activity as a quick assessment. As a larger assessment, learners can complete the Smart Attack game after they've completed several activities.

  17. O stars and Wolf-Rayet stars

    NASA Technical Reports Server (NTRS)

    Conti, Peter S.; Underhill, Anne B.; Jordan, Stuart (editor); Thomas, Richard (editor)

    1988-01-01

    Basic information is given about O and Wolf-Rayet stars indicating how these stars are defined and what their chief observable properties are. Part 2 of the volume discussed four related themes pertaining to the hottest and most luminous stars. Presented are: an observational overview of the spectroscopic classification and extrinsic properties of O and Wolf-Rayet stars; the intrinsic parameters of luminosity, effective temperature, mass, and composition of the stars, and a discussion of their viability; stellar wind properties; and the related issues concerning the efforts of stellar radiation and wind on the immediate interstellar environment are presented.

  18. 10830 A He I observations of 455 stars

    NASA Technical Reports Server (NTRS)

    Zirin, H.

    1982-01-01

    A comparison with K line, X-ray and other data, of 10830 A equivalent widths (EW) measurements in 890 image tube spectra of 455 stars shows that for the case of G stars, the EW correlates well with K line intensity. Good correlation is also found between 10830 A EW and soft X-ray fluxes, confirming the excitation of the line by coronal soft X-rays, which can serve as a measure of coronal emission. It is also found that, in contradiction to published models, 10830 A is weak or absent in O, B and A stars, and is absent in F and M supergiants. Moderate to high 10830 A EW is frequent in F and M dwarfs, G and K supergiants, and class K3 III. The 58 stars whose 10830 A EW was found to be of 300 A or more should be relatively intense X-ray emitters. Almost all RS CVn stars show strong 10830 A absorption, and T Tauri stars show both absorption and emission.

  19. Far UV Spectroscopy: Atmospheric Processes in Cool Stars

    NASA Astrophysics Data System (ADS)

    Brickhouse, Nancy S.

    1998-05-01

    New results from the far ultraviolet are increasing our understanding of the structure and dynamics of cool star atmospheres. The far UV spectrum bridges the gap between the chromospheric ultraviolet and the X-ray corona. The important O VI ion spans the range of activity from a diverse group of systems, and is formed near the peak of the emission measure distribution of less active stars like the Sun, while it is formed at the minimum of the distribution for the highly active RS CVn binaries and rapidly rotating young stars. Density diagnostics from C III, newly accessible with the lambda 977/lambda 1176 line ratio from ORFEUS, indicate a wide spread in transition region pressure among different systems as well. In active (i.e. closed field) regions, magnetic pressure confinement overcomes fluid domination in the transition region and allows quasi-static structures to support the steep temperature gradients, while in open field line regions (e.g. coronal holes) the wind begins its acceleration through steep gradients. New results from ORFEUS show the first evidence for warm winds in luminous hybrid stars, providing the critical link between solar-like stars with hot coronae and cooler stars with cool winds. Closer to home, the UVCS experiment on SOHO probes the diagnostic O VI doublet throughout the inner coronal region of the Sun. Observed line profiles indicate that ion temperatures in solar coronal holes are hotter than electron temperatures, demonstrating the importance of ion heating and acceleration processes.

  20. Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk

    Microsoft Academic Search

    Marie-Louise Lehmann; Silvia Selinski; Meinolf Blaszkewicz; Michael Orlich; Daniel Ovsiannikov; Oliver Moormann; Christoph Guballa; Alexander Kress; Michael C. Truss; Holger Gerullis; Thomas Otto; Dimitri Barski; Günter Niegisch; Peter Albers; Sebastian Frees; Walburgis Brenner; Joachim W. Thüroff; Miriam Angeli-Greaves; Thilo Seidel; Gerhard Roth; Holger Dietrich; Rainer Ebbinghaus; Hans M. Prager; Hermann M. Bolt; Michael Falkenstein; Anna Zimmermann; Torsten Klein; Thomas Reckwitz; Hermann C. Roemer; Dietrich Löhlein; Wobbeke Weistenhöfer; Wolfgang Schöps; Anwer E. Beg; Muhammad Aslam; Gergely Bánfi; Imre Romics; Katja Ickstadt; Holger Schwender; Andreas Winterpacht; Jan G. Hengstler; Klaus Golka

    2010-01-01

    Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associated with increased bladder cancer risk. To investigate the\\u000a association of rs710521[A] and bladder cancer by new data and by meta-analysis including all published data, rs710521 was\\u000a studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies.

  1. Insect nicotinic acetylcholine receptors (nAChRs): Important amino acid residues contributing to neonicotinoid insecticides selectivity and resistance

    Microsoft Academic Search

    Zewen Liu; Xiangmei Yao; Yixi Zhang

    2008-01-01

    Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels which mediate fast cholinergic synaptic transmission in insect and vertebrate nervous systems. The great abundance of nAChRs within the insect central nervous system has led to the development of insecticides targeting these receptors, such as neonicotinoid insecticides. Neonicotinoid insecticides act selectively on insect nAChRs, accounting at least in part for the selective

  2. PaRS: Parallel and Near-Optimal Grid-Based Cell Sizing for Library-Based Design

    Microsoft Academic Search

    Tai-Hsuan Wu; Azadeh Davoodi

    2009-01-01

    We propose PaRS, a parallel and randomized al- gorithm and tool to solve the discrete gate sizing (cell sizing) problem on a grid. PaRS is formulated based on an optimization framework known as Nested Partitions which we adopt for the first time in the CAD area. PaRS uses parallelism from a novel perspective to better identify the optimization direction. It

  3. P-bRS: a physarum-based routing scheme for wireless sensor networks.

    PubMed

    Zhang, Mingchuan; Wei, Wangyang; Zheng, Ruijuan; Wu, Qingtao

    2014-01-01

    Routing in wireless sensor networks (WSNs) is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH). Based on this model, we present a novel Physarum-based routing scheme (P-bRS) for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms. PMID:24672326

  4. Determination of climatic potential of Qom province for rain fed wheat using RS and GIS

    NASA Astrophysics Data System (ADS)

    Yazdan Panah, H.; Soleimani Tabar, M.

    2010-09-01

    This investigation was done to determine climatic potential of Qom province for wheat culture using RS and GIS. After collecting meteorological and wheat phonological data of available stations in Qom and its adjacent provinces we analyzed the data to obtain agrometeorological indices which affects on growth and yield of wheat. In the next step for these indices (the maximum and minimum temperature, sunshine hours, relative humidity, slope, elevation, GDD,rainfall,wind.land use and thermal stresses) we prepared separate maps using GIS and RS. Finally the above mentioned layers were overlaid to obtain agroclimatic map of wheat in Qom province. Results showed that about 30.2 percent of province is very suitable,53.5 percent is suitable,15.2 percent is moderate and 1.1 percent is not suitable for wheat culturing. Key words: Agrometeorology, GIS, RS, Wheat

  5. P-bRS: A Physarum-Based Routing Scheme for Wireless Sensor Networks

    PubMed Central

    Wei, Wangyang; Zheng, Ruijuan; Wu, Qingtao

    2014-01-01

    Routing in wireless sensor networks (WSNs) is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH). Based on this model, we present a novel Physarum-based routing scheme (P-bRS) for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms. PMID:24672326

  6. Genetic Algorithm to Make Persistent Security and Quality of Image in Steganography from RS Analysis

    E-print Network

    Nair, T R Gopalakrishnan; S, Manas

    2012-01-01

    Retention of secrecy is one of the significant features during communication activity. Steganography is one of the popular methods to achieve secret communication between sender and receiver by hiding message in any form of cover media such as an audio, video, text, images etc. Least significant bit encoding is the simplest encoding method used by many steganography programs to hide secret message in 24bit, 8bit colour images and grayscale images. Steganalysis is a method of detecting secret message hidden in a cover media using steganography. RS steganalysis is one of the most reliable steganalysis which performs statistical analysis of the pixels to successfully detect the hidden message in an image. However, existing steganography method protects the information against RS steganalysis in grey scale images. This paper presents a steganography method using genetic algorithm to protect against the RS attack in colour images. Stego image is divided into number of blocks. Subsequently, with the implementation ...

  7. rs10865331 Associated with Susceptibility and Disease Severity of Ankylosing Spondylitis in a Taiwanese Population

    PubMed Central

    Chiou, Hung-Yi; Wong, Henry Sung-Ching; Wong, Ruey-Hong; Ikegawa, Shiro; Chang, Wei-Chiao

    2014-01-01

    Ankylosing spondylitis (AS) is a highly familial rheumatic disorder and is considered as a chronic inflammatory disease. Genetic factors are involved in the pathogenesis of AS. To identify genes which render people susceptible to AS in a Taiwanese population, we selected six single-nucleotide polymorphisms (SNPs) from previous genome-wide association studies (GWASs) which were associated with AS in European descendants and Han Chinese. To assess whether the six SNPs contributed to AS susceptibility and severity in Taiwanese population, 475 AS patients fulfilling the modified New York Criteria and 527 healthy subjects were recruited. We found that rs10865331 was significantly associated with AS susceptibility and with Bath AS Function Index (BASFI). The AA and AG genotypes of rs10865331 were also significantly associated with a higher erythrocyte sedimentation rate. Our findings provided evidence that rs10865331 is associated AS susceptibility and with disease activity (BASFI) in a Taiwanese population. PMID:25184745

  8. Counting Your Lucky Stars

    NSDL National Science Digital Library

    Shannon Ricles

    2013-01-30

    In this activity, learners sample a star field to estimate the number of stars in the universe. This activity simulates how astronomers use sampling instead of census (counting) to more easily collect data in space. Learners predict, count, approximate, and average the number of stars in a Star Field Sheet.

  9. RR Lyrae Stars

    NASA Astrophysics Data System (ADS)

    Smith, Horace A.

    2004-09-01

    Preface; 1. Introduction; 2. The absolute magnitude of the RR Lyrae stars; 3. RR Lyrae stars in globular clusters; 4. RR Lyrae stars of the galactic field; 5. Period changes, the Blanzhko effect, and the double mode pulsation; 6. RR Lyrae stars beyond the Milky Way; Glossary of symbols; Short list of journal abbreviations; References; Index.

  10. Chemical Chaperones Exceed the Chaperone Effects of RIC-3 in Promoting Assembly of Functional ?7 AChRs

    PubMed Central

    Kuryatov, Alexander; Mukherjee, Jayanta; Lindstrom, Jon

    2013-01-01

    Functional ?7 nicotinic acetylcholine receptors (AChRs) do not assemble efficiently in cells transfected with ?7 subunits unless the cells are also transfected with the chaperone protein RIC-3. Despite the presence of RIC-3, large amounts of these subunits remain improperly assembled. Thus, additional chaperone proteins are probably required for efficient assembly of ?7 AChRs. Cholinergic ligands can act as pharmacological chaperones to promote assembly of mature AChRs and upregulate the amount of functional AChRs. In addition, we have found that the chemical chaperones 4-phenylbutyric acid (PBA) and valproic acid (VPA) greatly increase the amount of functional ?7 AChRs produced in a cell line expressing both ?7 and RIC-3. Increased ?7 AChR expression allows assay of drug action using a membrane potential-sensitive fluorescent indicator. Both PBA and VPA also increase ?7 expression in the SH-SY5Y neuroblastoma cell line that endogenously expresses ?7 AChRs. VPA increases expression of endogenous ?7 AChRs in hippocampal neurons but PBA does not. RIC-3 is insufficient for optimal assembly of ?7 AChRs, but provides assay conditions for detecting additional chaperones. Chemical chaperones are a useful pragmatic approach to express high levels of human ?7 AChRs for drug selection and characterization and possibly to increase ?7 expression in vivo. PMID:23638015

  11. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.

    PubMed

    Warnatz, Hans-Jörg; Schmidt, Dominic; Manke, Thomas; Piccini, Ilaria; Sultan, Marc; Borodina, Tatiana; Balzereit, Daniela; Wruck, Wasco; Soldatov, Alexey; Vingron, Martin; Lehrach, Hans; Yaspo, Marie-Laure

    2011-07-01

    The regulation of gene expression in response to environmental signals and metabolic imbalances is a key step in maintaining cellular homeostasis. BTB and CNC homology 1 (BACH1) is a heme-binding transcription factor repressing the transcription from a subset of MAF recognition elements at low intracellular heme levels. Upon heme binding, BACH1 is released from the MAF recognition elements, resulting in increased expression of antioxidant response genes. To systematically address the gene regulatory networks involving BACH1, we combined chromatin immunoprecipitation sequencing analysis of BACH1 target genes in HEK 293 cells with knockdown of BACH1 using three independent types of small interfering RNAs followed by transcriptome profiling using microarrays. The 59 BACH1 target genes identified by chromatin immunoprecipitation sequencing were found highly enriched in genes showing expression changes after BACH1 knockdown, demonstrating the impact of BACH1 repression on transcription. In addition to known and new BACH1 targets involved in heme degradation (HMOX1, FTL, FTH1, ME1, and SLC48A1) and redox regulation (GCLC, GCLM, and SLC7A11), we also discovered BACH1 target genes affecting cell cycle and apoptosis pathways (ITPR2, CALM1, SQSTM1, TFE3, EWSR1, CDK6, BCL2L11, and MAFG) as well as subcellular transport processes (CLSTN1, PSAP, MAPT, and vault RNA). The newly identified impact of BACH1 on genes involved in neurodegenerative processes and proliferation provides an interesting basis for future dissection of BACH1-mediated gene repression in neurodegeneration and virus-induced cancerogenesis. PMID:21555518

  12. Successful fabrication of a convex platform PMMA cell-counting slide using a high-precision perpendicular dual-spindle CNC machine tool

    NASA Astrophysics Data System (ADS)

    Chen, Shun-Tong; Chang, Chih-Hsien

    2013-12-01

    This study presents a novel approach to the fabrication of a biomedical-mold for producing convex platform PMMA (poly-methyl-meth-acrylate) slides for counting cells. These slides allow for the microscopic examination of urine sediment cells. Manufacturing of such slides incorporates three important procedures: (1) the development of a tabletop high-precision dual-spindle CNC (computerized numerical control) machine tool; (2) the formation of a boron-doped polycrystalline composite diamond (BD-PCD) wheel-tool on the machine tool developed in procedure (1); and (3) the cutting of a multi-groove-biomedical-mold array using the formed diamond wheel-tool in situ on the developed machine. The machine incorporates a hybrid working platform providing wheel-tool thinning using spark erosion to cut, polish, and deburr microgrooves on NAK80 steel directly. With consideration given for the electrical conductive properties of BD-PCD, the diamond wheel-tool is thinned to a thickness of 5 µm by rotary wire electrical discharge machining. The thinned wheel-tool can grind microgrooves 10 µm wide. An embedded design, which inserts a close fitting precision core into the biomedical-mold to create step-difference (concave inward) of 50 µm in height between the core and the mold, is also proposed and realized. The perpendicular dual-spindles and precision rotary stage are features that allow for biomedical-mold machining without the necessity of uploading and repositioning materials until all tasks are completed. A PMMA biomedical-slide with a plurality of juxtaposed counting chambers is formed and its usefulness verified.

  13. Swift X-ray and ultraviolet observations of the shortest orbital period double-degenerate system RX J0806.3+1527 (HM Cnc)

    NASA Astrophysics Data System (ADS)

    Esposito, Paolo; Israel, Gian Luca; Dall'Osso, Simone; Covino, Stefano

    2014-01-01

    The system RX J0806.3+1527 (HM Cnc) is a pulsating X-ray source with 100 per cent modulation on a period of 321.5 s (5.4 min). This period reflects the orbital motion of a close binary consisting of two interacting white dwarfs. Here we present a series of simultaneous X-ray (0.2-10 keV) and near-ultraviolet (2600 Å and 1928 Å) observations that were carried out with the Swift satellite. In the near-ultraviolet, the counterpart of RX J0806.3+1527 was detected at flux densities consistent with a blackbody with a temperature of (27 ± 8) × 103 K. We found that the emission at 2600 Å is modulated at the 321.5-s period with the peak ahead of the X-ray one by 0.28 ± 0.02 cycles and is coincident within ± 0.05 cycles with the optical. This phase-shift measurement confirms that the X-ray hot spot (located on the primary white dwarf) is at about 80°-100° from the direction that connects the two white dwarfs. Albeit at lower significance, the 321.5-s signature is also present in the 1928-Å data; at this wavelength, however, the pulse peak is better aligned with that observed at X-rays. We use the constraints on the source luminosity and the geometry of the emitting regions to discuss the merits and limits of the main models for RX J0806.3+1527.

  14. CHRNA4 rs1044396 is associated with smoking cessation in varenicline therapy

    PubMed Central

    Rocha Santos, Juliana; Tomaz, Paulo R. X.; Issa, Jaqueline S.; Abe, Tânia O.; Krieger, José E.; Pereira, Alexandre C.; Santos, Paulo C. J. L.

    2015-01-01

    Background: The large individual variability in response to drugs for smoking cessation suggests that specific treatments can be more effective in particular subgroups of smokers. In the context of personalized medicine, the main aim of the present study was to evaluate whether the CHRNA4 and CHRNB2 polymorphisms are associated with response to smoking cessation therapies in patients from a smoker assistance program. Methods: This cohort study enrolled 483 smoking patients who received behavioral counseling and drug treatment (varenicline, bupropion, and/or nicotine replacement therapy). Smoking cessation success was considered for patients who completed 6 months of continuous abstinence. Fagerström test for nicotine dependence (FTND) and Issa situational smoking scores were analyzed for nicotine dependence. The CHRNA4 (rs1044396 and rs2236196) and CHRNB2 (rs2072660 and rs2072661) polymorphisms were genotyped by high resolution melting analysis. Results: Patients with rs1044396 CC genotype had lower success rate in treatment with varenicline (29.5%) compared with carriers of CT or TT genotypes (50.9%; p = 0.007, n = 167). The CT or TT genotypes were associated with higher odds ratio for success (OR = 1.67, 95% CI = 1.10–2.53, p = 0.02), in a multivariate model. We did not observe significant differences in the FTND and Issa scores according to the studied polymorphisms. Conclusion: The CHRNA4 rs1044396 is associated with smoking cessation in individuals on varenicline therapy. We suggest that this polymorphism influences the varenicline response, but replications of this finding are needed. PMID:25774163

  15. devRS, an autoregulated and essential genetic locus for fruiting body development in Myxococcus xanthus.

    PubMed Central

    Thöny-Meyer, L; Kaiser, D

    1993-01-01

    Two Tn5 lac insertions into the Myxococcus genome at sites omega 4414 and omega 4473, which are separated by 550 nucleotides, inactivate fruiting body development. Sporulation is decreased 100- to 10,000-fold. At least two genes, devR and devS, are transcribed in this region, probably as an operon. Expression of devR begins by 6 h after starvation has initiated development. On the basis of their nucleotide sequences, devR and devS are expected to encode proteins of 302 and 214 amino acids, respectively. Dev+ function can be restored by a segment of 7.8 kb cloned from the devRS region of wild-type cells. Two experiments show that devR expression is under strong negative autoregulation. beta-Galactosidase is expressed at a higher level from a transcriptional devR::lacZ fusion when the fused operon is in a dev strain than when it is in the dev/dev+ genetic background of a partial diploid. There is more mRNA accumulation from the devRS region in the dev strain than in a rescued dev/dev+ tandem duplication strain. Sporulation rescue is correlated with some degree of negative autoregulation, even though sporulation is not inversely proportional to beta-galactosidase expression from omega 4414. A second level of regulation is suggested by complementation of dev by dev+ in duplication strains. The expression of devRS, measured by sporulation levels, differs 1,000-fold when devRS+ is moved from a distance of 20 kb to 3 Mb from the mutant devRS locus. Expression of devR is also dependent on the cell density at which development is initiated, a third level of regulation. Multiple levels of regulation suggest that devRS is a switch required to activate completion of aggregation and sporulation. Images PMID:7693658

  16. RS 23597-190: a potent and selective 5-HT4 receptor antagonist.

    PubMed Central

    Eglen, R. M.; Bley, K.; Bonhaus, D. W.; Clark, R. D.; Hegde, S. S.; Johnson, L. G.; Leung, E.; Wong, E. H.

    1993-01-01

    1. The pharmacological properties of RS 23597-190 (3-(piperdine-1-yl)-propyl-4-amino-5-chloro-2-methoxy benzoate hydrochloride) have been studied in vitro and in vivo. 2. RS 23597-190 competitively antagonized 5-HT4 receptor-mediated relaxations of rat, carbachol precontracted oesophageal muscularis mucosae, (pA2 = 7.8 +/- 0.1; Schild slope = 1.2 +/- 0.2). Affinity estimates (-log KB) at 5-HT4 receptors using either renzapride or SC-53116 as agonists yielded a -log KB value of 8.0 +/- 0.01. In contrast, RS 23597-190 failed to antagonize contractile responses to 5-HT of guinea-pig ileal 5-HT3 receptors, even at concentrations up to 10 microM. 3. Increases in short-circuit current, induced by 5-HT, were studied in guinea-pig ileal mucosal sheets. Concentration-response curves to 5-HT were biphasic, with the high potency phase to 5-HT inhibited by RS 23597-190 and mimicked by 5-methoxytryptamine. The -log KB value for RS 23597-190 at the high potency phase was 7.3 confirming that 5-HT4 receptors mediated the high potency phase. 4. In rat isolated vagus nerve, 5-HT elicited a slow, maintained depolarization at low concentrations and a rapid, transient depolarization at higher concentrations. The high potency, slow depolarizing phase to 5-HT was abolished selectively in the presence of 1 microM RS 23597-190 and the low potency phase was abolished selectively in the presence of 1 microM ondansetron. These data confirm that 5-HT4 and 5-HT3 receptors mediated slow and fast depolarization responses, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8220871

  17. Current evidence on the relationship between rs1256049 polymorphism in estrogen receptor-? gene and cancer risk

    PubMed Central

    Dai, Zhi-Jun; Wang, Bao-Feng; Ma, Yun-Feng; Kang, Hua-Feng; Diao, Yan; Zhao, Yang; Lin, Shuai; Lv, Ye; Wang, Meng; Wang, Xi-Jing

    2014-01-01

    Previous studies have suggested that estrogen receptor-? (ESR2) rs1256049 polymorphism is associated with the susceptibility of cancer. However, the results are inconsistent. We performed a meta-analysis to evaluate the association between the rs1256049 polymorphism and cancer risk. PubMed, ISI Web of Knowledge, and Chinese National Knowledge Infrastructure (CNKI), were searched for eligible studies. The odds ratios (ORs) with 95% confidence interval (CI) were used to assess the strength of association. 22 studies including 22,994 cases and 30,514 controls were identified. There was no significant association between rs1256049 and cancer risk in the overall population. Stratified analysis by ethnicity revealed that the rs1256049 polymorphism was associated with cancer risk in Caucasians (A vs. G: OR = 1.09, 95% CI = 1.01-1.16; GA vs. GG: OR = 1.10, 95% CI = 1.02-1.18; AA+GA vs. GG: OR = 1.09, 95% CI = 1.02-1.17), but not in Asians. Further subgroup analysis by cancer type indicated that the rs1256049 polymorphism may contribute to prostate cancer risk (AA vs. GG: OR = 1.41, 95% CI = 1.02-1.96; AA vs. GG+GA: OR = 1.52, 95% CI = 1.10-2.10), whereas negative results were obtained for breast cancer in any genetic model. This meta-analysis suggested that the ESR2 rs1256049 polymorphism is a candidate gene polymorphism for cancer susceptibility in Caucasians, especially in prostate cancer. PMID:25664002

  18. Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia

    PubMed Central

    Kim, Keun Hyang; Kim, Min-Kyoung; Choi, Tai Kiu; Lee, Sang-Hyuk

    2014-01-01

    Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene (VRK2), in multiple Asian and European samples. However, its effect on the brain structure in schizophrenia is little known. We analyzed the brain structure of 36 schizophrenia patients and 18 healthy subjects with regard to rs2312147 genotype groups. Brain magnetic resonance scans for gray matter (GM) and white matter (WM) analysis, and genotype analysis for VRK2 rs2312147, were conducted. The Positive and Negative Syndrome Scale and the Digit Symbol Test were assessed for schizophrenia patients. There was no significant difference in either GM volume or WM connectivity with regard to rs2312147 genotype in healthy subjects. In contrast, we found significant differences in the WM connectivity between rs2312147 CC and CT/TT genotype groups of schizophrenia patients. The related brain areas included the splenium of corpus callosum, the left occipital lobe WM, the internal capsule (left anterior limb and right retrolenticular part), the bilateral temporal lobe WM, the left fornix/stria terminalis, the left cingulate gyrus WM, and the left parietal lobe WM. Voxelwise correlation analysis revealed that the Digit Symbol Test scores (age corrected) correlated with the fractional anisotropy in WM tracts that previously showed significant group differences between the CT/TT and CC genotypes in the rs2312147 CT/TT genotype group, while no significant correlation was found in the CC genotype group. Our data may provide evidence for the effect of VRK2 on WM connectivity in patients with schizophrenia. PMID:25079070

  19. New and Redesigned pRS Plasmid Shuttle Vectors for Genetic Manipulation of Saccharomyces cerevisiae

    PubMed Central

    Chee, Mark K.; Haase, Steven B.

    2012-01-01

    We have constructed a set of 42 plasmid shuttle vectors based on the widely used pRS series for use in the budding yeast Saccharomyces cerevisiae and the bacterium Escherichia coli. This set of pRSII plasmids includes new shuttle vectors that can be used with histidine and adenine auxotrophic laboratory yeast strains carrying mutations in the genes HIS2 and ADE1, respectively. Our pRSII plasmids also include updated versions of commonly used pRS plasmids from which common restriction sites that occur within their yeast-selectable biosynthetic marker genes have been removed to increase the availability of unique restriction sites within their polylinker regions. Hence, our pRSII plasmids are a complete set of integrating, centromere and 2? episomal plasmids with the biosynthetic marker genes ADE2, HIS3, TRP1, LEU2, URA3, HIS2, and ADE1 and a standardized selection of at least 16 unique restriction sites in their polylinkers. Additionally, we have expanded the range of drug selection options that can be used for PCR-mediated homologous replacement using pRS plasmid templates by replacing the G418-resistance kanMX4 cassette of pRS400 with MX4 cassettes encoding resistance to phleomycin, hygromycin B, nourseothricin, and bialaphos. Finally, in the process of generating the new plasmids, we have determined several errors in existing publicly available sequences for several commonly used yeast plasmids. Using our updated sequences, we constructed pRS plasmid backbones with a unique restriction site for inserting new markers to facilitate future expansion of the pRS series. PMID:22670222

  20. Star-spots activity on BH Virginis

    NASA Astrophysics Data System (ADS)

    Xiang, F. Y.; Deng, S. F.; Liu, Q. Y.

    2000-10-01

    BH Virginis is a short-period RS CVn system. From our observations and archival sources we have gained an ephemeris by means of the times of minima. The light curves and the photoelectric observations in B and V obtained by Koch (\\cite{Koch1967}) have been analyzed by using the Wilson-Devinney program. The principal results are as follows: (1) The mass ratio obtained from the photoelectric light curves is q = m_2/m_1=0.967, close to the spectroscopic value 0.968 obtained by Zhai et al. (\\cite{Zhai1990}). (2) The photospheric temperature of the primary, T_1, at two epochs (1963-1964 and 1991) was about 5945 K-6010 K. (3) Several spotted active regions are revealed on both components in 1963-1964 data sets, while only one small spotted active region appears on the secondary star in 1991.

  1. R+S^2 theories of gravity without big-bang singularity

    E-print Network

    Jia-An Lu

    2015-02-10

    The R+S^2 theories of gravity, where S^2 denotes the quadratic torsion terms, are analyzed under three cases. In the first two cases, the matter fields are described by two different spin fluids which are not homogeneous and isotropic. In the third case, a homogeneous and isotropic torsion field is used. It is found that under all the three cases, the R+S^2 theories may avert the big-bang singularity of the Robertson--Walker universe, with three corresponding constraints on the parameters.

  2. Improved Rs Monitoring for Robust Process Control of High Energy Well Implants

    NASA Astrophysics Data System (ADS)

    Kim, J. H.; Kim, S.; Ra, G. J.; Lee, K. W.; Reece, R. N.; Bae, S. Y.

    2008-11-01

    We describe a robust method of improving precision in monitoring high energy ion implantation processes. Ion implant energy accuracy was measured using an unpatterned implanted layer on an intrinsic p-type silicon wafer. To increase Rs sensitivity to energy at the well implant process, a p-n junction structure was formed by p-well and deep n-well implants into the p-type Si wafer. It was observed that the depletion layer formed by the p-n junction was very sensitive to the energy variation of the well implant. Consequently, it can be recommended to monitor well implant processes using the Rs measurement method described herein.

  3. Implementation of RS-485 Communication between PLC and PC of Distributed Control System Based on VB

    NASA Astrophysics Data System (ADS)

    Lian Zhang, Chuan; Da Huang, Zhi; Qing Zhou, Gui; Chong, Kil To

    2015-05-01

    This paper focuses on achieving RS-485 communication between programmable logical controller (PLC) and PC based on visual basic 6.0 (VB6.0) on an experimental automatic production line. Mitsubishi FX2N PLCs and a PC are chosen as slave stations and main station, respectively. Monitoring software is developed using VB6.0 for data input/output, flow control and online parameters setting. As a result, all functions are fulfilled with robust performance. It is concluded from results that one PC can monitor several PLCs using RS-485 communication.

  4. Magnetic inhibition of convection and the fundamental properties of low-mass stars. I. Stars with a radiative core

    SciTech Connect

    Feiden, Gregory A. [Current address: Department of Physics and Astronomy, Uppsala University, Box 516, Uppsala 751 20, Sweden. (Sweden); Chaboyer, Brian, E-mail: gregory.a.feiden.gr@dartmouth.edu, E-mail: brian.chaboyer@dartmouth.edu [Department of Physics and Astronomy, Dartmouth College, 6127 Wilder Laboratory, Hanover, NH 03755 (United States)

    2013-12-20

    Magnetic fields are hypothesized to inflate the radii of low-mass stars—defined as less massive than 0.8 M {sub ?}—in detached eclipsing binaries (DEBs). We investigate this hypothesis using the recently introduced magnetic Dartmouth stellar evolution code. In particular, we focus on stars thought to have a radiative core and convective outer envelope by studying in detail three individual DEBs: UV Psc, YY Gem, and CU Cnc. Our results suggest that the stabilization of thermal convection by a magnetic field is a plausible explanation for the observed model-radius discrepancies. However, surface magnetic field strengths required by the models are significantly stronger than those estimated from observed coronal X-ray emission. Agreement between model predicted surface magnetic field strengths and those inferred from X-ray observations can be found by assuming that the magnetic field sources its energy from convection. This approach makes the transport of heat by convection less efficient and is akin to reduced convective mixing length methods used in other studies. Predictions for the metallicity and magnetic field strengths of the aforementioned systems are reported. We also develop an expression relating a reduction in the convective mixing length to a magnetic field strength in units of the equipartition value. Our results are compared with those from previous investigations to incorporate magnetic fields to explain the low-mass DEB radius inflation. Finally, we explore how the effects of magnetic fields might affect mass determinations using asteroseismic data and the implication of magnetic fields on exoplanet studies.

  5. Retinoschisin (RS1) Interacts with Negatively Charged Lipid Bilayers in the presence of Ca2+: An Atomic Force Microscopy Study

    PubMed Central

    Kotova, Svetlana; Vijayasarathy, Camasamudram; Dimitriadis, Emilios K.; Ikonomou, Laertis; Jaffe, Howard; Sieving, Paul A.

    2010-01-01

    Retinoschisin (RS1) is a retina-specific secreted protein encoding a conserved discoidin domain sequence. As an adhesion molecule, RS1 preserves the retinal cell architecture and promotes visual signal transduction. In young males, loss-of-function mutations in the X- linked retinoschisis gene (RS1) cause X-linked retinoschisis, a form of progressive blindness. Neither the structure of RS1 nor the nature of its anchoring and organization on the plasma membranes is fully understood. The discoidin C2 domains of coagulation factors V and VIII are known to interact with extracellular phosphatidylserine (PS). In this study we have used atomic force microscopy (AFM) to study the interactions of murine retinoschisin (Rs1) with supported anionic lipid bilayers in the presence of Ca2+. The bilayers consisting of a single lipid, PS, and mixtures of lipids with or without PS were used. Consistent with previous X-ray diffraction studies, AFM imaging showed two distinct domains in pure PS bilayers when Ca2+ was present. Upon Rs1 adsorption, these PS and PS-containing mixed bilayers underwent fast and extensive reorganization. Protein localization was ascertained by immunolabeling. AFM imaging showed the Rs1 antibody bound exclusively to the calcium-rich ordered phase of the bilayers pointing to the sequestration of Rs1 within those domains. This was further supported by the increased mechanical strength of these domains after Rs1 binding. Besides, changes in bilayer thickness suggested that Rs1 was partially embedded into the bilayer. These findings support a model whereby the Rs1 protein binds to PS in the retinal cell plasma membranes in a calcium-dependent manner. PMID:20677810

  6. Retrospective Analysis of Antigen Prevalences of Renibacterium salmoninarum (Rs) Detected by Enzyme-Linked Immunosorbent Assay in Alaskan Pacific Salmon and Trout from 1988 to 2000 and Management of Rs in Hatchery Chinook and Coho Salmon

    Microsoft Academic Search

    T. R. Meyers; D. Korn; K. Glass; T. Burton; S. Short; K. Lipson; N. Starkey

    2003-01-01

    Five species of anadromous Pacific salmon Oncorhynchus spp. and eight species of nonanadromous fish, including trouts Oncorhynchus and Salvelinus spp., Arctic char S. alpinus, and Arctic grayling Thymallus arcticus (collectively called “trout”), from Alaskan waters were examined by enzyme-linked immunosorbent assay for annual and total prevalences of Renibacterium salmoninarum (Rs) from 1988 to 2000. The total prevalence of Rs antigen

  7. Remote Sens. 2009, 1, 519-533; doi:10.3390/rs1030519 Remote Sensing

    E-print Network

    MacDonald, Lee

    Remote Sens. 2009, 1, 519-533; doi:10.3390/rs1030519 Remote Sensing ISSN 2072-4292 www 7 ETM+ satellite scenes and a suite of vegetation indices at different times of the growing season projects despite intensive labor requirements, associated high economic costs, and incomplete coverage

  8. Remote Sens. 2013, 5, 2492-2512; doi:10.3390/rs5052492 OPEN ACCESS

    E-print Network

    Remote Sens. 2013, 5, 2492-2512; doi:10.3390/rs5052492 OPEN ACCESS Remote Sensing ISSN 2072 of greening in pasture cells is significantly higher than for cells dominated by natural vegetation and browning trends in global pasture lands, including a comparison with vegetation trends in regions dominated

  9. Remote Sens. 2013, 5, 845-861; doi:10.3390/rs5020845 Remote Sensing

    E-print Network

    Myneni, Ranga B.

    and continuous geographic coverage. Because metrics and thresholds of vegetation indices may not directlyRemote Sens. 2013, 5, 845-861; doi:10.3390/rs5020845 Remote Sensing ISSN 2072-4292 www Abstract: Using estimated leaf unfolding data and two types of Normalized Difference Vegetation Index (NDVI

  10. A family of RS domain proteins with novel subcellular localization and trafficking

    PubMed Central

    Kavanagh, Steven J.; Schulz, Thomas C.; Davey, Philippa; Claudianos, Charles; Russell, Carrie; Rathjen, Peter D.

    2005-01-01

    We report the sequence, conservation and cell biology of a novel protein, Psc1, which is expressed and regulated within the embryonic pluripotent cell population of the mouse. The Psc1 sequence includes an RS domain and an RNA recognition motif (RRM), and a sequential arrangement of protein motifs that has not been demonstrated for other RS domain proteins. This arrangement was conserved in a second mouse protein (BAC34721). The identification of Psc1 and BAC34721 homologues in vertebrates and related proteins, more widely throughout evolution, defines a new family of RS domain proteins termed acidic rich RS (ARRS) domain proteins. Psc1 incorporated into the nuclear speckles, but demonstrated novel aspects of subcellular distribution including localization to speckles proximal to the nuclear periphery and localization to punctate structures in the cytoplasm termed cytospeckles. Integration of Psc1 into cytospeckles was dependent on the RRM. Cytospeckles were dynamic within the cytoplasm and appeared to traffic into the nucleus. These observations suggest a novel role in RNA metabolism for ARRS proteins. PMID:15741184

  11. Clinical Features: Patients with Robinow syndrome (RS) [OMIM #268310] have characteristic facial features, growth

    E-print Network

    Gilad, Yoav

    tract anomalies, rib fusions and nail hypoplasia or dystrophy. Approximately 10% of children with RS (BDB1) [OMIM #113000] have hypoplasia/aplasia of the distal phalanges and nails. Middle phalanges to the tyrosine kinase domain cause a severe, amputation- like phenotype affecting three or more fingers, whereas

  12. Clinical Features: Patients with Robinow syndrome (RS) [OMIM #268310] have characteristic facial features, growth

    E-print Network

    Ober, Carole

    tract anomalies, rib fusions and nail hypoplasia or dystrophy. Approximately 10% of children with RS] have hypoplasia/aplasia of the distal phalanges and nails. Middle phalanges are short and terminal domain cause a severe, amputation- like phenotype affecting three or more fingers, whereas proximal

  13. A Simple Method for Specifying the R/S Configuration about a Chiral Center.

    ERIC Educational Resources Information Center

    Idoux, John P.

    1982-01-01

    Describes a method for specifying R/S (clockwise/counterclockwise) configuration about a chiral center which does not require the use of a three-dimensional physical model, the mental visualization of the molecule, or the memorization of a recently reported arbitrary number system. (Author/JN)

  14. A hybrid model for portfolio selection based on Grey Relational Analysis and RS theories

    Microsoft Academic Search

    Kuang Yu Huang; Chuen-Jiuan Jane; Ting-Cheng Chang

    2010-01-01

    In this study, the Grey Relational Analysis (GRA) model is combined with Fuzzy C-Means (FCM) clustering scheme and Rough Set (RS) theory to create an automatic portfolio selection mechanism. In the proposed approach, 53 financial indices are collected automatically for each stock item every quarter and a GRA model is used to consolidate these indices into six predetermined financial ratios

  15. ESTUDO DA UTILIZAÇÃO DE ANFO NA MINA DE CARVÃO DO RECREIO, BUTIÁ, RS

    Microsoft Academic Search

    Enrique Munaretti; João Felipe; Coimbra Leite; João Francisco Linck Feijó

    The ANFO utilization ha s been fundamental i n the de velopment of t he mining industry, allowing reduction o f costs and improving safety. The Brazilian coal sector traditionally uses nitroglycerin and emulsion. This work shows the de velopment of mixtures from different ammonium nitrate prill grades and oils at Mina do Recreio, Butiá, RS, to a chieve the

  16. RS and GIS-based analysis of urban heat island effect in Shanghai

    Microsoft Academic Search

    Kang Xiao; Huiping Xu

    2010-01-01

    The urban heat island effect (UHI) has caught great attention with the fast urbanization processes. UHI leads to the worsening environment due to its contribution to intensely high temperature, particularly in the summer. The effect of summer UHI has been concerned in the whole urban ecological system. Taking Shanghai as an example, two distinct ETM+ remote sensing (RS) images are

  17. VDM-RS: A visual data mining system for exploring and classifying remotely sensed images

    E-print Network

    Gruenwald, Le

    applications domains, such as environmental monitoring, change detection, fire risk mapping and land useVDM-RS: A visual data mining system for exploring and classifying remotely sensed images Jianting 2009 Accepted 20 February 2009 Keywords: Data mining Visualization Remote sensing Image classification

  18. Liverpool Telescope Optical Photometry Following the 2006 Outburst of RS Ophiuchi

    E-print Network

    M. J. Darnley; R. A. Hounsell; M. F. Bode

    2008-09-26

    We present a preliminary report on the broadband optical photometry of the 2006 outburst of the recurrent nova RS Ophiuchi. These data were obtained using the robotic 2m Liverpool Telescope and cover the outburst from day 27 through day 548.

  19. Association between vaspin rs2236242 gene polymorphism and polycystic ovary syndrome risk.

    PubMed

    Kohan, Leila; Zarei, Ali; Fallahi, Sara; Tabiee, Omid

    2014-04-15

    Vaspin, an adipocytokine that has been isolated from the visceral adipose tissue, is a member of the serine protease inhibitor family. In humans, serum vaspin levels are correlated with body mass index (BMI) and obese women with polycystic ovary syndrome (PCOS). The present study is the first investigation to examine the association between vaspin rs2236242 gene polymorphism and risk of PCOS in Iranian patients. This case-control study was performed on 150 patients with PCOS and 150 healthy women. The vaspin genotypes were determined using tetra-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). Our finding showed that there are significant differences in genotype frequencies between case and control group regarding vaspin rs2236242 polymorphism (OR=0.59, CI=0.37-0.95, p=0.03). The A allele decreased the risk of PCOS (OR=0.67, CI=0.46-0.96, p=0.03) as compared to the T allele. There was no significant association between vaspin rs2236242 gene polymorphism and PCOS after adjusting genotypes for BMI. In conclusion, our data suggest a significant association between vaspin rs2236242 polymorphism and the PCOS but this relationship is affected by obesity status. PMID:24530312

  20. Mouse U2af1-rs1 is a neomorphic imprinted gene.

    PubMed Central

    Nabetani, A; Hatada, I; Morisaki, H; Oshimura, M; Mukai, T

    1997-01-01

    The mouse U2af1-rs1 gene is an endogenous imprinted gene on the proximal region of chromosome 11. This gene is transcribed exclusively from the unmethylated paternal allele, while the methylated maternal allele is silent. An analysis of genome structure of this gene revealed that the whole gene is located in an intron of the Murr1 gene. Although none of the three human U2af1-related genes have been mapped to chromosome 2, the human homolog of Murr1 is assigned to chromosome 2. The mouse Murr1 gene is transcribed biallelically, and therefore it is not imprinted in neonatal mice. Allele-specific methylation is limited to a region around U2af1-rs1 in an intron of Murr1. These results suggest that in chromosomal homology and genomic imprinting, the U2af1-rs1 gene is distinct from the genome region surrounding it. We have proposed the neomorphic origin of the U2af1-rs1 gene by retrotransposition and the particular mechanism of genomic imprinting of ectopic genes. PMID:9001233