Science.gov

Sample records for string-guided fast transport

  1. A model for fast axonal transport.

    PubMed

    Blum, J J; Reed, M C

    1985-01-01

    A model for fast axonal transport is developed in which the essential features are that organelles may interact with mechanochemical cross-bridges that in turn interact with microtubules, forming an organelle-engine-microtubule complex which is transported along the microtubules. Computer analysis of the equations derived to describe such a system show that most of the experimental observations on fast axonal transport can be simulated by the model, indicating that the model is useful for the interpretation and design of experiments aimed at clarifying the mechanism of fast axonal transport. PMID:2416456

  2. Fast algorithms for transport models

    SciTech Connect

    Manteuffel, T.A.

    1992-12-01

    The objective of this project is the development of numerical solution techniques for deterministic models of the transport of neutral and charged particles and the demonstration of their effectiveness in both a production environment and on advanced architecture computers. The primary focus is on various versions of the linear Boltzman equation. These equations are fundamental in many important applications. This project is an attempt to integrate the development of numerical algorithms with the process of developing production software. A major thrust of this reject will be the implementation of these algorithms on advanced architecture machines that reside at the Advanced Computing Laboratory (ACL) at Los Alamos National Laboratories (LANL).

  3. Fast atomic transport without vibrational heating

    SciTech Connect

    Torrontegui, E.; Ibanez, S.; Chen Xi; Ruschhaupt, A.; Guery-Odelin, D.; Muga, J. G.

    2011-01-15

    We use the dynamical invariants associated with the Hamiltonian of an atom in a one dimensional moving trap to inverse engineer the trap motion and perform fast atomic transport without final vibrational heating. The atom is driven nonadiabatically through a shortcut to the result of adiabatic, slow trap motion. For harmonic potentials this only requires designing appropriate trap trajectories, whereas perfect transport in anharmonic traps may be achieved by applying an extra field to compensate the forces in the rest frame of the trap. The results can be extended to atom stopping or launching. The limitations due to geometrical constraints, energies, and accelerations involved are analyzed along with the relation to previous approaches based on classical trajectories or ''fast-forward'' and ''bang-bang'' methods, which can be integrated in the invariant-based framework.

  4. Automated measurement of fast mitochondrial transport in neurons

    PubMed Central

    Miller, Kyle E.; Liu, Xin-An; Puthanveettil, Sathyanarayanan V.

    2015-01-01

    There is growing recognition that fast mitochondrial transport in neurons is disrupted in multiple neurological diseases and psychiatric disorders. However, a major constraint in identifying novel therapeutics based on mitochondrial transport is that the large-scale analysis of fast transport is time consuming. Here we describe methodologies for the automated analysis of fast mitochondrial transport from data acquired using a robotic microscope. We focused on addressing questions of measurement precision, speed, reliably, workflow ease, statistical processing, and presentation. We used optical flow and particle tracking algorithms, implemented in ImageJ, to measure mitochondrial movement in primary cultured cortical and hippocampal neurons. With it, we are able to generate complete descriptions of movement profiles in an automated fashion of hundreds of thousands of mitochondria with a processing time of approximately one hour. We describe the calibration of the parameters of the tracking algorithms and demonstrate that they are capable of measuring the fast transport of a single mitochondrion. We then show that the methods are capable of reliably measuring the inhibition of fast mitochondria transport induced by the disruption of microtubules with the drug nocodazole in both hippocampal and cortical neurons. This work lays the foundation for future large-scale screens designed to identify compounds that modulate mitochondrial motility. PMID:26578890

  5. Automated measurement of fast mitochondrial transport in neurons.

    PubMed

    Miller, Kyle E; Liu, Xin-An; Puthanveettil, Sathyanarayanan V

    2015-01-01

    There is growing recognition that fast mitochondrial transport in neurons is disrupted in multiple neurological diseases and psychiatric disorders. However, a major constraint in identifying novel therapeutics based on mitochondrial transport is that the large-scale analysis of fast transport is time consuming. Here we describe methodologies for the automated analysis of fast mitochondrial transport from data acquired using a robotic microscope. We focused on addressing questions of measurement precision, speed, reliably, workflow ease, statistical processing, and presentation. We used optical flow and particle tracking algorithms, implemented in ImageJ, to measure mitochondrial movement in primary cultured cortical and hippocampal neurons. With it, we are able to generate complete descriptions of movement profiles in an automated fashion of hundreds of thousands of mitochondria with a processing time of approximately one hour. We describe the calibration of the parameters of the tracking algorithms and demonstrate that they are capable of measuring the fast transport of a single mitochondrion. We then show that the methods are capable of reliably measuring the inhibition of fast mitochondria transport induced by the disruption of microtubules with the drug nocodazole in both hippocampal and cortical neurons. This work lays the foundation for future large-scale screens designed to identify compounds that modulate mitochondrial motility. PMID:26578890

  6. Fast Ignition Transport Simulations for NIF

    SciTech Connect

    Strozzi, D J; Grote, D P; Tabak, M; Cohen, B I; Town, R P; Kemp, A J

    2009-10-05

    This paper shows work at Lawrence Livermore National Lab (LLNL) devoted to modeling the propagation of, and heating by, a relativistic electron beam in a idealized dense fuel assembly for fast ignition. The implicit particle-in-cell (PIC) code LSP is used. Experiments planned on the National Ignition Facility (NIF) in the next few years using the Advanced Radiography Capability (ARC) short-pulse laser motivate this work. We demonstrate significant improvement in the heating of dense fuel due to magnetic forces, increased beam collimation, and insertion of a finite-radius carbon region between the beam excitation and fuel regions.

  7. Fast electron generation and transport in a turbulent, magnetized plasma

    SciTech Connect

    Stoneking, W.R.

    1994-05-01

    The nature of fast electron generation and transport in the Madison Symmetric Torus (MST) reversed field pinch (RFP) is investigated using two electron energy analyzer (EEA) probes and a thermocouple calorimeter. The parallel velocity distribution of the fast electron population is well fit by a drifted Maxwellian distribution with temperature of about 100 eV and drift velocity of about 2 {times} 10{sup 6} m/s. Cross-calibration of the EEA with the calorimeter provides a measurement of the fast electron perpendicular temperature of 30 eV, much lower than the parallel temperature, and is evidence that the kinetic dynamo mechanism (KDT) is not operative in MST. The fast electron current is found to match to the parallel current at the edge, and the fast electron density is about 4 {times} 10{sup 11} cm{sup {minus}3} independent of the ratio of the applied toroidal electric field to the critical electric field for runaways. First time measurements of magnetic fluctuation induced particle transport are reported. By correlating electron current fluctuations with radial magnetic fluctuations the transported flux of electrons is found to be negligible outside r/a{approximately}0.9, but rises the level of the expected total particle losses inside r/a{approximately}0.85. A comparison of the measured diffusion coefficient is made with the ausilinear stochastic diffusion coefficient. Evidence exists that the reduction of the transport is due to the presence of a radial ambipolar electric field of magnitude 500 V/m, that acts to equilibrate the ion and electron transport rates. The convective energy transport associated with the measured particle transport is large enough to account for the observed magnetic fluctuation induced energy transport in MST.

  8. Transport Simulations for Fast Ignition on NIF

    SciTech Connect

    Strozzi, D J; Tabak, M; Grote, D P; Cohen, B I; Shay, H D; Town, R J; Kemp, A J; Key, M

    2009-10-26

    We are designing a full hydro-scale cone-guided, indirect-drive FI coupling experiment, for NIF, with the ARC-FIDO short-pulse laser. Current rad-hydro designs with limited fuel jetting into cone tip are not yet adequate for ignition. Designs are improving. Electron beam transport simulations (implicit-PIC LSP) show: (1) Magnetic fields and smaller angular spreads increase coupling to ignition-relevant 'hot spot' (20 um radius); (2) Plastic CD (for a warm target) produces somewhat better coupling than pure D (cryogenic target) due to enhanced resistive B fields; and (3) The optimal T{sub hot} for this target is {approx} 1 MeV; coupling falls by 3x as T{sub hot} rises to 4 MeV.

  9. Fast algorithms for transport models. Final report

    SciTech Connect

    Manteuffel, T.A.

    1994-10-01

    This project has developed a multigrid in space algorithm for the solution of the S{sub N} equations with isotropic scattering in slab geometry. The algorithm was developed for the Modified Linear Discontinuous (MLD) discretization in space which is accurate in the thick diffusion limit. It uses a red/black two-cell {mu}-line relaxation. This relaxation solves for all angles on two adjacent spatial cells simultaneously. It takes advantage of the rank-one property of the coupling between angles and can perform this inversion in O(N) operations. A version of the multigrid in space algorithm was programmed on the Thinking Machines Inc. CM-200 located at LANL. It was discovered that on the CM-200 a block Jacobi type iteration was more efficient than the block red/black iteration. Given sufficient processors all two-cell block inversions can be carried out simultaneously with a small number of parallel steps. The bottleneck is the need for sums of N values, where N is the number of discrete angles, each from a different processor. These are carried out by machine intrinsic functions and are well optimized. The overall algorithm has computational complexity O(log(M)), where M is the number of spatial cells. The algorithm is very efficient and represents the state-of-the-art for isotropic problems in slab geometry. For anisotropic scattering in slab geometry, a multilevel in angle algorithm was developed. A parallel version of the multilevel in angle algorithm has also been developed. Upon first glance, the shifted transport sweep has limited parallelism. Once the right-hand-side has been computed, the sweep is completely parallel in angle, becoming N uncoupled initial value ODE`s. The author has developed a cyclic reduction algorithm that renders it parallel with complexity O(log(M)). The multilevel in angle algorithm visits log(N) levels, where shifted transport sweeps are performed. The overall complexity is O(log(N)log(M)).

  10. Transportation fuels from biomass via fast pyrolysis and hydroprocessing

    SciTech Connect

    Elliott, Douglas C.

    2013-09-21

    Biomass is a renewable source of carbon, which could provide a means to reduce the greenhouse gas impact from fossil fuels in the transportation sector. Biomass is the only renewable source of liquid fuels, which could displace petroleum-derived products. Fast pyrolysis is a method of direct thermochemical conversion (non-bioconversion) of biomass to a liquid product. Although the direct conversion product, called bio-oil, is liquid; it is not compatible with the fuel handling systems currently used for transportation. Upgrading the product via catalytic processing with hydrogen gas, hydroprocessing, is a means that has been demonstrated in the laboratory. By this processing the bio-oil can be deoxygenated to hydrocarbons, which can be useful replacements of the hydrocarbon distillates in petroleum. While the fast pyrolysis of biomass is presently commercial, the upgrading of the liquid product by hydroprocessing remains in development, although it is moving out of the laboratory into scaled-up process demonstration systems.

  11. Reduced Fast Ion Transport Model For The Tokamak Transport Code TRANSP

    SciTech Connect

    Podesta,, Mario; Gorelenkova, Marina; White, Roscoe

    2014-02-28

    Fast ion transport models presently implemented in the tokamak transport code TRANSP [R. J. Hawryluk, in Physics of Plasmas Close to Thermonuclear Conditions, CEC Brussels, 1 , 19 (1980)] are not capturing important aspects of the physics associated with resonant transport caused by instabilities such as Toroidal Alfv en Eigenmodes (TAEs). This work describes the implementation of a fast ion transport model consistent with the basic mechanisms of resonant mode-particle interaction. The model is formulated in terms of a probability distribution function for the particle's steps in phase space, which is consistent with the MonteCarlo approach used in TRANSP. The proposed model is based on the analysis of fast ion response to TAE modes through the ORBIT code [R. B. White et al., Phys. Fluids 27 , 2455 (1984)], but it can be generalized to higher frequency modes (e.g. Compressional and Global Alfv en Eigenmodes) and to other numerical codes or theories.

  12. The mechanical cost of transport of fast running animals.

    PubMed

    Fuentes, Mauricio A

    2014-03-21

    Regarding running animals, algebraic expressions for the horizontal (ωx) and vertical (ωy) components of the mechanical cost of transport are deduced for a ground force pattern based on the Spring-mass model. Defining μ˜ as the maximum ground forces ratio μ˜=max(Fx)/max(Fy), the analysis shows that the mechanical cost of transport ωx+ωy for fast running animals is approximately proportional to μ˜, and to the relative contact length, and positively correlated to the limb take-off angle and the collision angle. The vertical cost ωy is shown to approximate to zero for fast running animals. Sustained top running speeds are predicted to require the largest possible values of μ˜ and therefore relatively large horizontal propulsive forces, as well as a minimum possible ground contact time. The equations also show that animals running relatively slow would tend to prefer certain interval of values for parameter μ˜, which would minimize both their mechanical cost of transport and their metabolic cost of transport. Very large animals are suspected to be less capable of developing large values of μ˜, which possibly renders them incapable of developing great speeds. PMID:24333209

  13. Membranes for nanometer-scale mass fast transport

    DOEpatents

    Bakajin, Olgica; Holt, Jason; Noy, Aleksandr; Park, Hyung Gyu

    2011-10-18

    Nanoporous membranes comprising single walled, double walled, and multiwalled carbon nanotubes embedded in a matrix material were fabricated for fluid mechanics and mass transfer studies on the nanometer scale and commercial applications. Average pore size can be 2 nm to 20 nm, or seven nm or less, or two nanometers or less. The membrane can be free of large voids spanning the membrane such that transport of material such as gas or liquid occurs exclusively through the tubes. Fast fluid, vapor, and liquid transport are observed. Versatile micromachining methods can be used for membrane fabrication. A single chip can comprise multiple membranes. These membranes are a robust platform for the study of confined molecular transport, with applications in liquid and gas separations and chemical sensing including desalination, dialysis, and fabric formation.

  14. Behaviour of fast electron transport in solid targets

    NASA Astrophysics Data System (ADS)

    Koenig, M.; Baton, S. D.; Benuzzi-Mounaix, A.; Fuchs, J.; Loupias, B.; Guillou, P.; Batani, D.; Morace, A.; Piazza, D.; Kodama, R.; Norimatsu, T.; Nakatsutsumi, M.; Aglitskiy, Y.; Rousseaux, C.

    2006-06-01

    One of the main issues of the fast ignitor scheme is the role of fast electron transport in the solid fuel heating. Recent experiments used a new target scheme based on the use of cone to guide the PW laser and enhance the electron production. In this context it is fundamental to understand the physics underlying this new target scheme. We report here recent and preliminary results of ultra-intense laser pulse interaction with three layer targets in presence of the cone or without. Experiments have been performed at LULI with the 100 TW laser facility, at intensities up to 3 1019 W/cm2. Several diagnostics have been implemented (2D Kα imaging, Kα spectroscopy and rear side imaging, protons emission) to quantify the cone effect.

  15. Energy transport in ultra-fast eated solid targets

    NASA Astrophysics Data System (ADS)

    Sentoku, Yasuhiko; Johzaki, Tomoyuki; Kemp, Andreas

    2008-11-01

    We discuss hot electron generation in ultra intense laser interaction with initially non-ionized matter. Hot electron energy and the transport inside the target are strongly affected by collisional effects and ionization processes, especially in high-Z material. We have introduced an ionization model into our collisional particle-in-cell code, PICLS, to study hot electron transport in ultra-fast heated matter. Our description of collisional ionization is based on the Thomas-Fermi model, where a local average charge state is calculated from the bulk electron temperature and density. Field ionization is taken into account for ionization of low density plasmas. We have studied laser matter interaction under an irradiation of a laser with 10^20W/cm^2. A strong heat inhibition within a micron distance was observed in a gold target because of the large number of lower energy hot electrons produced at the steepened interface by the laser photon pressure. We will discuss the generation of hot electrons and their transport in ultra-fast heated solid targets of various materials.

  16. Fast and efficient transport of large ion clouds

    NASA Astrophysics Data System (ADS)

    Kamsap, M. R.; Pedregosa-Gutierrez, J.; Champenois, C.; Guyomarc'h, D.; Houssin, M.; Knoop, M.

    2015-10-01

    The manipulation of trapped charged particles by electric fields is an accurate, robust, and reliable technique for many applications or experiments in high-precision spectroscopy. The transfer of an ion sample between multiple traps allows the use of a tailored environment in quantum information, cold chemistry, or frequency metrology experiments. In this article, we experimentally study the transport of ion clouds of up to 80 000 ions over a distance of 20 mm inside a linear radio-frequency trap. Ion transport is controlled by a transfer function, which is designed taking into account the local electric potentials. We observe that the ion response is very sensitive to the details of the description of the electric potential. Nevertheless, we show that fast transport—with a total duration of 100 μ s —results in transport efficiencies attaining values higher than 90% of the ion number, even with large ion clouds. For clouds smaller than 2000 ions, a 100% transfer efficiency is observed. Transport induced heating, which depends on the transport duration, is also analyzed.

  17. A Novel and Fast Purification Method for Nucleoside Transporters.

    PubMed

    Hao, Zhenyu; Thomsen, Maren; Postis, Vincent L G; Lesiuk, Amelia; Sharples, David; Wang, Yingying; Bartlam, Mark; Goldman, Adrian

    2016-01-01

    Nucleoside transporters (NTs) play critical biological roles in humans, and to understand the molecular mechanism of nucleoside transport requires high-resolution structural information. However, the main bottleneck for structural analysis of NTs is the production of pure, stable, and high quality native protein for crystallization trials. Here we report a novel membrane protein expression and purification strategy, including construction of a high-yield membrane protein expression vector, and a new and fast purification protocol for NTs. The advantages of this strategy are the improved time efficiency, leading to high quality, active, stable membrane proteins, and the efficient use of reagents and consumables. Our strategy might serve as a useful point of reference for investigating NTs and other membrane proteins by clarifying the technical points of vector construction and improvements of membrane protein expression and purification. PMID:27376071

  18. A Novel and Fast Purification Method for Nucleoside Transporters

    PubMed Central

    Hao, Zhenyu; Thomsen, Maren; Postis, Vincent L. G.; Lesiuk, Amelia; Sharples, David; Wang, Yingying; Bartlam, Mark; Goldman, Adrian

    2016-01-01

    Nucleoside transporters (NTs) play critical biological roles in humans, and to understand the molecular mechanism of nucleoside transport requires high-resolution structural information. However, the main bottleneck for structural analysis of NTs is the production of pure, stable, and high quality native protein for crystallization trials. Here we report a novel membrane protein expression and purification strategy, including construction of a high-yield membrane protein expression vector, and a new and fast purification protocol for NTs. The advantages of this strategy are the improved time efficiency, leading to high quality, active, stable membrane proteins, and the efficient use of reagents and consumables. Our strategy might serve as a useful point of reference for investigating NTs and other membrane proteins by clarifying the technical points of vector construction and improvements of membrane protein expression and purification. PMID:27376071

  19. Modeling Fast Ion Transport in TAE Avalanches in NSTX

    SciTech Connect

    Fredrickson, E D; Bell, R E; Darrow, D; Gorelenkov, N N; Kramer, G; Kubota, S; Levinton, F M; Liu, D; Medley, S S; Podesta, M; Tritz, K

    2009-08-17

    Experiments on the National Spherical Torus Experiment [M. Ono, et al., Nucl. Fusion 40 (2000) 557 ] have found strong bursts of Toroidal Alfven Eigenmode (TAE) activity correlated with abrupt drops in the neutron rate. A fairly complete data set offers the opportunity to benchmark the NOVA [C. Z. Cheng, Phys. Reports 211, 1-51 (1992)] and ORBIT [R. B. White and M. S. Chance, Phys. Fluids 27, 2455 (1984)] codes in the low aspect ratio tokamak (ST) geometry. The internal structure of TAE were modeled with NOVA and good agreement is found with measurements made with an array of five fixed-frequency reflectometers. The fast-ion transport resulting from these bursts of multiple TAE were then modeled with the ORBIT code. The simulations are reasonably consistent with the observed drop in neutron rate. While these results represent our best attempts to find agreement, we believe that further refinements in both the simulation of the TAE structure and in the modeling of the fast ion transport are needed. Benchmarking stability codes against present experiments is an important step in developing the predictive capability needed to plan future experiments.

  20. Design of a transportable high efficiency fast neutron spectrometer

    NASA Astrophysics Data System (ADS)

    Roecker, C.; Bernstein, A.; Bowden, N. S.; Cabrera-Palmer, B.; Dazeley, S.; Gerling, M.; Marleau, P.; Sweany, M. D.; Vetter, K.

    2016-08-01

    A transportable fast neutron detection system has been designed and constructed for measuring neutron energy spectra and flux ranging from tens to hundreds of MeV. The transportability of the spectrometer reduces the detector-related systematic bias between different neutron spectra and flux measurements, which allows for the comparison of measurements above or below ground. The spectrometer will measure neutron fluxes that are of prohibitively low intensity compared to the site-specific background rates targeted by other transportable fast neutron detection systems. To measure low intensity high-energy neutron fluxes, a conventional capture-gating technique is used for measuring neutron energies above 20 MeV and a novel multiplicity technique is used for measuring neutron energies above 100 MeV. The spectrometer is composed of two Gd containing plastic scintillator detectors arranged around a lead spallation target. To calibrate and characterize the position dependent response of the spectrometer, a Monte Carlo model was developed and used in conjunction with experimental data from gamma ray sources. Multiplicity event identification algorithms were developed and used with a Cf-252 neutron multiplicity source to validate the Monte Carlo model Gd concentration and secondary neutron capture efficiency. The validated Monte Carlo model was used to predict an effective area for the multiplicity and capture gating analyses. For incident neutron energies between 100 MeV and 1000 MeV with an isotropic angular distribution, the multiplicity analysis predicted an effective area of 500 cm2 rising to 5000 cm2. For neutron energies above 20 MeV, the capture-gating analysis predicted an effective area between 1800 cm2 and 2500 cm2. The multiplicity mode was found to be sensitive to the incident neutron angular distribution.

  1. Visualizing fast electron energy transport into laser-compressed high-density fast-ignition targets

    NASA Astrophysics Data System (ADS)

    Jarrott, L. C.; Wei, M. S.; McGuffey, C.; Solodov, A. A.; Theobald, W.; Qiao, B.; Stoeckl, C.; Betti, R.; Chen, H.; Delettrez, J.; Döppner, T.; Giraldez, E. M.; Glebov, V. Y.; Habara, H.; Iwawaki, T.; Key, M. H.; Luo, R. W.; Marshall, F. J.; McLean, H. S.; Mileham, C.; Patel, P. K.; Santos, J. J.; Sawada, H.; Stephens, R. B.; Yabuuchi, T.; Beg, F. N.

    2016-05-01

    Recent progress in kilojoule-scale high-intensity lasers has opened up new areas of research in radiography, laboratory astrophysics, high-energy-density physics, and fast-ignition (FI) laser fusion. FI requires efficient heating of pre-compressed high-density fuel by an intense relativistic electron beam produced from laser-matter interaction. Understanding the details of electron beam generation and transport is crucial for FI. Here we report on the first visualization of fast electron spatial energy deposition in a laser-compressed cone-in-shell FI target, facilitated by doping the shell with copper and imaging the K-shell radiation. Multi-scale simulations accompanying the experiments clearly show the location of fast electrons and reveal key parameters affecting energy coupling. The approach provides a more direct way to infer energy coupling and guide experimental designs that significantly improve the laser-to-core coupling to 7%. Our findings lay the groundwork for further improving efficiency, with 15% energy coupling predicted in FI experiments using an existing megajoule-scale laser driver.

  2. Fast ion transport induced by saturated infernal mode

    SciTech Connect

    Marchenko, V. S.

    2014-05-15

    Tokamak discharges with extended weak-shear central core are known to suffer from infernal modes when the core safety factor approaches the mode ratio. These modes can cause an outward convection of the well-passing energetic ions deposited in the core by fusion reactions and/or neutral beam injection. Convection mechanism consists in collisional slowing down of energetic ions trapped in the Doppler-precession resonance with a finite-amplitude infernal mode. Convection velocity can reach a few m/s in modern spherical tori. Possible relation of this transport with the enhanced fast ion losses in the presence of “long lived modes” in the MAST tokamak [I. T. Chapman et al., Nucl. Fusion 50, 045007 (2010)] is discussed.

  3. Fast-electron transport in cylindrically laser-compressed matter

    NASA Astrophysics Data System (ADS)

    Perez, F.; Koenig, M.; Batani, D.; Baton, S. D.; Beg, F. N.; Benedetti, C.; Brambrink, E.; Chawla, S.; Dorchies, F.; Fourment, C.; Galimberti, M.; Gizzi, L. A.; Heathcote, R.; Higginson, D. P.; Hulin, S.; Jafer, R.; Koester, P.; Labate, L.; Lancaster, K.; Mac Kinnon, A. J.; McPhee, A. G.; Nazarov, W.; Nicolai, P.; Pasley, J.; Ravasio, A.; Richetta, M.; Santos, J. J.; Sgattoni, A.; Spindloe, C.; Vauzour, B.; Volpe, L.

    2009-12-01

    Experimental and theoretical results of relativistic electron transport in cylindrically compressed matter are presented. This experiment, which is a part of the HiPER roadmap, was achieved on the VULCAN laser facility (UK) using four long pulses beams (~4 × 50 J, 1 ns, at 0.53 µm) to compress a hollow plastic cylinder filled with plastic foam of three different densities (0.1, 0.3 and 1 g cm-3). 2D simulations predict a density of 2-5 g cm-3 and a plasma temperature up to 100 eV at maximum compression. A short pulse (10 ps, 160 J) beam generated fast electrons that propagate through the compressed matter by irradiating a nickel foil at an intensity of 5 × 1018 W cm-2. X-ray spectrometer and imagers were implemented in order to estimate the compressed plasma conditions and to infer the hot electron characteristics. Results are discussed and compared with simulations.

  4. Calculations of Electron Transport in Fast Ignition Targets.

    NASA Astrophysics Data System (ADS)

    Town, R. P. J.; Kruer, W. L.; Langdon, A. B.; Lasinski, B. F.; Tabak, M.; Welch, D. R.

    2002-11-01

    A crucial issue for the viability of the fast ignition approach [1] to inertial fusion energy is the transport of the ignition pulse energy from the critical surface to the high-density compressed fuel. For example, the ignition beam energy depends on the cross section area of the electron beam. Experiments of the interaction of short-pulse high intensity lasers with surrogate solid-density thin targets with buried K-α diagnostic layers have shown a fairly well collimated beam although with a larger radius than the laser beam spot [2]. We report on LSP calculations of these experiments. These calculations include the effects of non-normal electron beam injection, an effect previously not included in simulations. The LSP code [3] uses a direct implicit particle-in-cell algorithm in 3 dimensions to solve for the beam particles. The background particles are treated as a fluid. The implications for fast ignition will be discussed. This work was performed under the auspices of the U.S. Department of Energy by the University of California, Lawrence Livermore National Laboratory under contract W-7405-ENG-48. [1] M. Tabak, et al, Phys. Plasmas 1, 1626 (1994). [2] J. A. Koch, et al, Phys. Rev. E 65, 016410-1 (2001). [3] D. R. Welch, D. V. Rose, B. V. Oliver, and R. E. Clark, Nucl. Inst. Meth. Phys. Res. A 242, 134 (2001).

  5. Effect of runaway electrons on transport in Fast Ignition targets

    NASA Astrophysics Data System (ADS)

    Tabak, Max; Kruer, William; Langdon, A. Bruce; Lasinski, Barbara; Town, Richard; Welch, Dale

    2002-11-01

    A crucial issue for the viability of the fast ignition approach [1] to inertial fusion energy is the transport of the ignitor pulse energy from the critical surface to the high-density compressed fuel. For example, the required ignitor beam energy depends on the cross section area of the electron beam. Experiments of the interaction of short-pulse high intensity lasers with surrogate solid-density thin targets have shown, a fairly well collimated beam [2]. We report on LSP calculations of these experiments. The LSP code [3] uses a direct implicit particle-in-cell algorithm in 3 dimensions to solve for the beam particles. The background particles are treated as fluid particles. The behavior of the return current is essential in controlling the background plasma heating as well as the beam propagation. Previous calculations have used the collisional resistivity of a fluid bath for the return current. We estimate the effects of runaway electrons on the electron transport. In addition we make estimates of the effects of various microinstabilities on the effective collisionality. Analytic estimates and preliminary LSP calculations will be shown. The implications for fast ignition will be discussed. [1] M. Tabak, et al, Phys. Plasmas 1, 1626 (1994). [2] J. A. Koch, et al, Phys. Rev. E 65, 016410-1 (2001). [3] D. R. Welch, D. V. Rose, B. V. Oliver, and R. E. Clark, Nucl. Inst. Meth. Phys. Res. A 242, 134 (2001). *This work was performed under the auspices of the U.S. Department of Energy by University of California Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48.

  6. Fast electron transport and spatial energy deposition in imploded fast ignition cone-in-shell targets

    NASA Astrophysics Data System (ADS)

    Jarrott, Leonard

    2014-10-01

    We report on the first experimental observation and model validation of the spatial energy deposition of fast electrons into the imploded, high-density core of integrated cone-in-shell fast ignition experiments on OMEGA. Spatial energy deposition was characterized via fast electron produced K α fluorescence from a Cu tracer added to the CD shell. 2-D images of the Cu K α fluorescence were obtained using a spherically bent Bragg crystal imager. 54 of the 60 OMEGA beams (18 kJ) were used for fuel assembly, and the high intensity EP beam (10 ps, 0.5--1.5 kJ, Ip >1019 W/cm2) , was focused onto the inner cone tip to produce fast electrons. Cu K α emission from a 300 μm region surrounding the cone tip correlated well with the predicted core size from radiation-hydrodynamic simulations of the shell implosion. The emission also emanated from as far back as 100 μm from the cone tip, indicative of an electron source position with a large standoff distance from the cone tip, consistent with the presence of an extended pre-plasma from the EP pre-pulse. We observed a simultaneous increase in both K α yield (up to 70%) and thermal neutron number (up to 2×) with increasing EP beam energy. K α yield data also show an improved energy coupling using the high contrast EP pulse. Comprehensive simulations of the electron production within the cone and subsequent transport into the imploded core have been performed using the implicit PIC code LSP and the hybrid-PIC code ZUMA. These simulations explain the observed K α shape and yield trends and identify parameters that constrain energy coupling into the compressed core. This work was performed under the auspices of U.S. DOE under Contracts DE-FC02-04ER54789 (FSC), DE-FG02-05ER54834 (ACE) and DE-NA0000854 (NLUF).

  7. Fast electron transport in lower-hybrid current drive

    SciTech Connect

    Kupfer, K.; Bers, A.

    1991-01-01

    We generalize the quasilinear-Fokker-Planck formulation for lower-hybrid current drive to include the wave induced radial transport of fast electrons. Toroidal ray tracing shows that the wave fields in the plasma develop a large poloidal component associated with the upshift in k1l and the filling of the "spectral gap". These fields lead to an enhanced radial E x B drift of resonant electrons. Two types of radial flows are obtained: an outward convective flow driven by the asymmetry in the poloidal wave spectrum, and a diffusive flow proportional to the width of the poloidal spectrum. Simulations of Alcator C and JT60, show that the radial convection velocity has a broad maximum of nearly 1 m/sec and is independent of the amplitude of fields. In both cases, the radial diffusion is found to be highly localized near the magnetic axis. For JT60, the peak of the diffusion profile can be quite large, nearly 1 m2/sec.

  8. Bifurcation of Velocity Distributions in Cooperative Transport of Filaments by Fast and Slow Motors

    PubMed Central

    Li, Xin; Lipowsky, Reinhard; Kierfeld, Jan

    2013-01-01

    Several intracellular processes are governed by two different species of molecular motors, fast and slow ones, that both move in the same direction along the filaments but with different velocities. The transport of filaments arising from the cooperative action of these motors has been recently studied by three in vitro experiments, in which the filament velocity was measured for varying fraction of the fast motors adsorbed onto substrate surfaces in a gliding assay. As the fast motor fraction was increased, two experiments found a smooth change whereas the third one observed an abrupt increase of the filament velocity. Here, we show that all of these experimental results reflect the competition between fast and slow motors and can be understood in terms of an underlying saddle-node bifurcation. The comparison between theory and experiment leads to predictions for the detachment forces of the two motor species. Our theoretical study shows the existence of three different motility regimes: 1), fast transport with a single velocity; 2), slow transport with a single velocity; and 3), bistable transport, where the filament velocity stochastically switches between fast and slow transport. We determine the parameter regions for these regimes in terms of motility diagrams as a function of the surface fraction of fast motors and microscopic single-motor parameters. An abrupt increase of the filament velocity for an increasing fraction of fast motors is associated with the occurrence of bistable transport. PMID:23442917

  9. Influence of low-temperature resistivity on fast electron transport in solids: scaling to fast ignition electron beam parameters

    NASA Astrophysics Data System (ADS)

    McKenna, P.; MacLellan, D. A.; Butler, N. M. H.; Dance, R. J.; Gray, R. J.; Robinson, A. P. L.; Neely, D.; Desjarlais, M. P.

    2015-06-01

    The role of low-temperature electrical resistivity in defining the transport properties of mega-Ampere currents of fast (MeV) electrons in solids is investigated using 3D hybrid particle-in-cell (PIC) simulations. By considering resistivity profiles intermediate to the ordered (lattice) and disordered forms of two example materials, lithium and silicon, it is shown that both the magnitude of the resistivity and the shape of the resistivity-temperature profile at low temperatures strongly affect the self-generated resistive magnetic fields and the onset of resistive instabilities, and thus the overall fast electron beam transport pattern. The scaling of these effects to the giga-Ampere electron currents required for the fast ignition scheme for inertial fusion is also explored.

  10. DIRECT MEASUREMENT OF FAST AXONAL ORGANELLE TRANSPORT IN THE SCIATIC NERVE OF RATS TREATED WITH ACRYLAMIDE

    EPA Science Inventory

    The effects of acrylamide on fast axonal transport have been measured primarily using the indirect methods of isotope or enzyme accumulation. e report the first direct evaluation of the effects of sub-chronic acrylamide dosing (150, 300 or 500 mg/kg total dose) on the fast axonal...

  11. Fast axonal transport of kinesin in the rat visual system: functionality of kinesin heavy chain isoforms.

    PubMed Central

    Elluru, R G; Bloom, G S; Brady, S T

    1995-01-01

    The mechanochemical ATPase kinesin is thought to move membrane-bounded organelles along microtubules in fast axonal transport. However, fast transport includes several classes of organelles moving at rates that differ by an order of magnitude. Further, the fact that cytoplasmic forms of kinesin exist suggests that kinesins might move cytoplasmic structures such as the cytoskeleton. To define cellular roles for kinesin, the axonal transport of kinesin was characterized. Retinal proteins were pulse-labeled, and movement of radiolabeled kinesin through optic nerve and tract into the terminals was monitored by immunoprecipitation. Heavy and light chains of kinesin appeared in nerve and tract at times consistent with fast transport. Little or no kinesin moved with slow axonal transport indicating that effectively all axonal kinesin is associated with membranous organelles. Both kinesin heavy chain molecular weight variants of 130,000 and 124,000 M(r) (KHC-A and KHC-B) moved in fast anterograde transport, but KHC-A moved at 5-6 times the rate of KHC-B. KHC-A cotransported with the synaptic vesicle marker synaptophysin, while a portion of KHC-B cotransported with the mitochondrial marker hexokinase. These results suggest that KHC-A is enriched on small tubulovesicular structures like synaptic vesicles and that at least one form of KHC-B is predominantly on mitochondria. Biochemical specialization may target kinesins to appropriate organelles and facilitate differential regulation of transport. Images PMID:7538359

  12. Effect of Target Material on Fast-Electron Transport and Resistive Collimation

    NASA Astrophysics Data System (ADS)

    Chawla, S.; Wei, M. S.; Mishra, R.; Akli, K. U.; Chen, C. D.; McLean, H. S.; Morace, A.; Patel, P. K.; Sawada, H.; Sentoku, Y.; Stephens, R. B.; Beg, F. N.

    2013-01-01

    The effect of target material on fast-electron transport is investigated using a high-intensity (0.7 ps, 1020W/cm2) laser pulse irradiated on multilayered solid Al targets with embedded transport (Au, Mo, Al) and tracer (Cu) layers, backed with millimeter-thick carbon foils to minimize refluxing. We consistently observed a more collimated electron beam (36% average reduction in fast-electron induced Cu Kα spot size) using a high- or mid-Z (Au or Mo) layer compared to Al. All targets showed a similar electron flux level in the central spot of the beam. Two-dimensional collisional particle-in-cell simulations showed formation of strong self-generated resistive magnetic fields in targets with a high-Z transport layer that suppressed the fast-electron beam divergence; the consequent magnetic channels guided the fast electrons to a smaller spot, in good agreement with experiments. These findings indicate that fast-electron transport can be controlled by self-generated resistive magnetic fields and may have important implications to fast ignition.

  13. Breakdown of fast water transport in graphene oxides.

    PubMed

    Wei, Ning; Peng, Xinsheng; Xu, Zhiping

    2014-01-01

    Fast slip flow was identified for water inside the interlayer gallery between graphene layers or carbon nanotubes. We report here that this significant flow rate enhancement (over two orders) breaks down with the presence of chemical functionalization and relaxation of nanoconfinement in graphene oxides. Molecular dynamics simulation results show that hydrodynamics applies in this circumstance, even at length scales down to nanometers. However, corrections to the slip boundary condition and apparent viscosity of nanoconfined flow must be included to make quantitative predictions. These results were discussed with the structural characteristics of liquid water and hydrogen-bond networks. PMID:24580178

  14. Breakdown of fast water transport in graphene oxides

    NASA Astrophysics Data System (ADS)

    Wei, Ning; Peng, Xinsheng; Xu, Zhiping

    2014-01-01

    Fast slip flow was identified for water inside the interlayer gallery between graphene layers or carbon nanotubes. We report here that this significant flow rate enhancement (over two orders) breaks down with the presence of chemical functionalization and relaxation of nanoconfinement in graphene oxides. Molecular dynamics simulation results show that hydrodynamics applies in this circumstance, even at length scales down to nanometers. However, corrections to the slip boundary condition and apparent viscosity of nanoconfined flow must be included to make quantitative predictions. These results were discussed with the structural characteristics of liquid water and hydrogen-bond networks.

  15. Fast and Selective Ammonia Transport by Aquaporin-8*

    PubMed Central

    Saparov, Sapar M.; Liu, Kun; Agre, Peter; Pohl, Peter

    2010-01-01

    The transport of ammonia/ammonium is fundamental to nitrogen metabolism in all forms of life. So far, no clear picture has emerged as to whether a protein channel is capable of transporting exclusively neutral NH3 while excluding H+ and NH4+. Our research is the first stoichiometric study to show the selective transport of NH3 by a membrane channel. The purified water channel protein aquaporin-8 was reconstituted into planar bilayers, and the exclusion of NH4+ or H+ was established by ensuring a lack of current under voltage clamp conditions. The single channel water permeability coefficient of 1.2 × 10−14 cm3/subunit/s was established by imposing an osmotic gradient across reconstituted planar bilayers, and resulting minute changes in ionic concentration close to the membrane surface were detected. It is more than 2-fold smaller than the single channel ammonia permeability (2.7 × 10−14 cm3/subunit/s) that was derived by establishing a transmembrane ammonium concentration gradient and measuring the resulting concentration increases adjacent to the membrane. This permeability ratio suggests that electrically silent ammonia transport may be the main function of AQP8. PMID:17189259

  16. Simulations of Fuel Assembly and Fast-Electron Transport in Integrated Fast-Ignition Experiments on OMEGA

    NASA Astrophysics Data System (ADS)

    Solodov, A. A.; Theobald, W.; Anderson, K. S.; Shvydky, A.; Epstein, R.; Betti, R.; Myatt, J. F.; Stoeckl, C.; Jarrott, L. C.; McGuffey, C.; Qiao, B.; Beg, F. N.; Wei, M. S.; Stephens, R. B.

    2013-10-01

    Integrated fast-ignition experiments on OMEGA benefit from improved performance of the OMEGA EP laser, including higher contrast, higher energy, and a smaller focus. Recent 8-keV, Cu-Kα flash radiography of cone-in-shell implosions and cone-tip breakout measurements showed good agreement with the 2-D radiation-hydrodynamic simulations using the code DRACO. DRACO simulations show that the fuel assembly can be further improved by optimizing the compression laser pulse, evacuating air from the shell, and by adjusting the material of the cone tip. This is found to delay the cone-tip breakout by ~220 ps and increase the core areal density from ~80 mg/cm2 in the current experiments to ~500 mg/cm2 at the time of the OMEGA EP beam arrival before the cone-tip breakout. Simulations using the code LSP of fast-electron transport in the recent integrated OMEGA experiments with Cu-doped shells will be presented. Cu-doping is added to probe the transport of fast electrons via their induced Cu K-shell fluorescent emission. This material is based upon work supported by the Department of Energy National Nuclear Security Administration DE-NA0001944 and the Office of Science under DE-FC02-04ER54789.

  17. Fast transport simulation with an adaptive grid refinement.

    PubMed

    Haefner, Frieder; Boy, Siegrun

    2003-01-01

    One of the main difficulties in transport modeling and calibration is the extraordinarily long computing times necessary for simulation runs. Improved execution time is a prerequisite for calibration in transport modeling. In this paper we investigate the problem of code acceleration using an adaptive grid refinement, neglecting subdomains, and devising a method by which the Courant condition can be ignored while maintaining accurate solutions. Grid refinement is based on dividing selected cells into regular subcells and including the balance equations of subcells in the equation system. The connection of coarse and refined cells satisfies the mass balance with an interpolation scheme that is implicitly included in the equation system. The refined subdomain can move with the average transport velocity of the subdomain. Very small time steps are required on a fine or a refined grid, because of the combined effect of the Courant and Peclet conditions. Therefore, we have developed a special upwind technique in small grid cells with high velocities (velocity suppression). We have neglected grid subdomains with very small concentration gradients (zero suppression). The resulting software, MODCALIF, is a three-dimensional, modularly constructed FORTRAN code. For convenience, the package names used by the well-known MODFLOW and MT3D computer programs are adopted, and the same input file structure and format is used, but the program presented here is separate and independent. Also, MODCALIF includes algorithms for variable density modeling and model calibration. The method is tested by comparison with an analytical solution, and illustrated by means of a two-dimensional theoretical example and three-dimensional simulations of the variable-density Cape Cod and SALTPOOL experiments. Crossing from fine to coarse grid produces numerical dispersion when the whole subdomain of interest is refined; however, we show that accurate solutions can be obtained using a fraction of the

  18. Fast algorithms for transport models. Technical progress report

    SciTech Connect

    Manteuffel, T.A.

    1992-12-01

    The objective of this project is the development of numerical solution techniques for deterministic models of the transport of neutral and charged particles and the demonstration of their effectiveness in both a production environment and on advanced architecture computers. The primary focus is on various versions of the linear Boltzman equation. These equations are fundamental in many important applications. This project is an attempt to integrate the development of numerical algorithms with the process of developing production software. A major thrust of this reject will be the implementation of these algorithms on advanced architecture machines that reside at the Advanced Computing Laboratory (ACL) at Los Alamos National Laboratories (LANL).

  19. Fast model of electron transport for radiographic spectrum simulation

    SciTech Connect

    Deresch, A. Bellon, C. Jaenisch, G.-R. Ewert, U.

    2015-03-31

    Correctly modeling the continuous photon spectrum of X-ray tubes requires detailed knowledge of the probability distribution of electron properties at the time of X-ray photon creation, in particular electron energy, depth within the target, and direction of movement. Semi-analytical X-ray spectrum models frequently assume a very simplified or even uniform distribution of electron direction. In the case of thick targets and small deviations from normal incidence this is a useful approximation. For thin targets or large deviations from normal incidence the correct distribution of electron directions becomes more important. As calculation speed is an important aspect of semi-analytical models compared to Monte Carlo simulations, fast evaluation of the distribution of electron properties is highly desirable. The approach presented here numerically evaluates the evolution of a discrete probability distribution of electron properties due to single electron scatter interactions within a plane target. This allows capturing the important aspects of the electron distribution while achieving runtimes of a few seconds up to a minute on a standard office PC.

  20. On the Criticality Safety of Transuranic Sodium Fast Reactor Fuel Transport Casks

    SciTech Connect

    Samuel Bays; Ayodeji Alajo

    2010-05-01

    This work addresses the neutronic performance and criticality safety issues of transport casks for fuel pertaining to low conversion ratio sodium cooled fast reactors, conventionally known as Advanced Burner Reactors. The criticality of a one, three, seven and 19-assembly cask capacity is presented. Both dry “helium” and flooded “water” filled casks are considered. No credit for fuel burnup or fission products was assumed. As many as possible of the conservatisms used in licensing light water reactor universal transport casks were incorporated into this SFR cask criticality design and analysis. It was found that at 7-assemblies or more, adding moderator to the SFR cask increases criticality margin. Also, removal of MAs from the fuel increases criticality margin of dry casks and takes a slight amount of margin away for wet casks. Assuming credit for borated fuel tube liners, this design analysis suggests that as many as 19 assemblies can be loaded in a cask if limited purely by criticality safety. If no credit for boron is assumed, the cask could possibly hold seven assemblies if low conversion ratio fast reactor grade fuel and not breeder reactor grade fuel is assumed. The analysis showed that there is a need for new cask designs for fast reactors spent fuel transportation. There is a potential of modifying existing transportation cask design as the starting point for fast reactor spent fuel transportation.

  1. Energetic-particle-driven instabilities and induced fast-ion transport in a reversed field pinch

    SciTech Connect

    Lin, L.; Brower, D. L.; Ding, W. X.; Anderson, J. K.; Capecchi, W.; Eilerman, S.; Forest, C. B.; Koliner, J. J.; Nornberg, M. D.; Reusch, J.; Sarff, J. S.; Liu, D.

    2014-05-15

    Multiple bursty energetic-particle (EP) driven modes with fishbone-like structure are observed during 1 MW tangential neutral-beam injection in a reversed field pinch (RFP) device. The distinguishing features of the RFP, including large magnetic shear (tending to add stability) and weak toroidal magnetic field (leading to stronger drive), provide a complementary environment to tokamak and stellarator configurations for exploring basic understanding of EP instabilities. Detailed measurements of the EP mode characteristics and temporal-spatial dynamics reveal their influence on fast ion transport. Density fluctuations exhibit a dynamically evolving, inboard-outboard asymmetric spatial structure that peaks in the core where fast ions reside. The measured mode frequencies are close to the computed shear Alfvén frequency, a feature consistent with continuum modes destabilized by strong drive. The frequency pattern of the dominant mode depends on the fast-ion species. Multiple frequencies occur with deuterium fast ions compared to single frequency for hydrogen fast ions. Furthermore, as the safety factor (q) decreases, the toroidal mode number of the dominant EP mode transits from n=5 to n=6 while retaining the same poloidal mode number m=1. The transition occurs when the m=1, n=5 wave-particle resonance condition cannot be satisfied as the fast-ion safety factor (q{sub fi}) decreases. The fast-ion temporal dynamics, measured by a neutral particle analyzer, resemble a classical predator-prey relaxation oscillation. It contains a slow-growth phase arising from the beam fueling followed by a rapid drop when the EP modes peak, indicating that the fluctuation-induced transport maintains a stiff fast-ion density profile. The inferred transport rate is strongly enhanced with the onset of multiple EP modes.

  2. A fluctuation-induced plasma transport diagnostic based upon fast-Fourier transform spectral analysis

    NASA Technical Reports Server (NTRS)

    Powers, E. J.; Kim, Y. C.; Hong, J. Y.; Roth, J. R.; Krawczonek, W. M.

    1978-01-01

    A diagnostic, based on fast Fourier-transform spectral analysis techniques, that provides experimental insight into the relationship between the experimentally observable spectral characteristics of the fluctuations and the fluctuation-induced plasma transport is described. The model upon which the diagnostic technique is based and its experimental implementation is discussed. Some characteristic results obtained during the course of an experimental study of fluctuation-induced transport in the electric field dominated NASA Lewis bumpy torus plasma are presented.

  3. Fast axonal transport of labeled proteins in motoneurons of exercise-trained rats

    SciTech Connect

    Jasmin, B.J.; Lavoie, P.A.; Gardiner, P.F.

    1988-12-01

    In this study, the fast orthograde axonal transport of radiolabeled proteins was measured to determine the effects of endurance-running training on transport velocity and amounts of transported proteins in rat sciatic motoneurons. Female rats were subjected to a progressive running-training program for 10-12 wk. Twenty-four hours after the last training session, rats underwent right L4-L5 dorsal root ganglionectomy. The next day, 20 microCi of (3H)leucine was injected bilaterally in the vicinity of the motoneuronal cell bodies supplying the sciatic nerve, to study axonal transport parameters. Results showed that peak and average transport velocities of labeled proteins were significantly (P less than 0.05) increased by 22 and 29%, respectively, in the deafferented nerves of the runners as compared with controls. Moreover, the amount of total transported protein-bound radioactivity was increased in both left (40%) and right (37%) sciatic nerves of the runners. An exhaustive exercise session reduced (P less than 0.05) peak displacement (8%) and total transported protein-bound radioactivity (36%) in the sciatic nerves of control rats, whereas no changes were noticed in trained animals. The data suggest that chronic endurance running induces significant adaptations in the fast axonal transport of labeled proteins.

  4. Injection and transport properties of fast electrons in ultraintense laser-solid interactions

    SciTech Connect

    Coury, M.; Carroll, D. C.; Yuan, X. H.; Gray, R. J.; MacLellan, D. A.; Powell, H.; Quinn, M. N.; Tresca, O.; McKenna, P.; Robinson, A. P. L.; Lancaster, K. L.; Neely, D.; Brenner, C. M.; Burza, M.; Wahlstroem, C.-G.; Li, Y. T.; Lin, X. X.

    2013-04-15

    Fast electron injection and transport in solid foils irradiated by sub-picosecond-duration laser pulses with peak intensity equal to 4 Multiplication-Sign 10{sup 20} W/cm{sup 2} is investigated experimentally and via 3D simulations. The simulations are performed using a hybrid-particle-in-cell (PIC) code for a range of fast electron beam injection conditions, with and without inclusion of self-generated resistive magnetic fields. The resulting fast electron beam transport properties are used in rear-surface plasma expansion calculations to compare with measurements of proton acceleration, as a function of target thickness. An injection half-angle of {approx}50 Degree-Sign -70 Degree-Sign is inferred, which is significantly larger than that derived from previous experiments under similar conditions.

  5. Experimental evidence of electric inhibition in fast electron penetration and of electric-field-limited fast electron transport in dense matter

    PubMed

    Pisani; Bernardinello; Batani; Antonicci; Martinolli; Koenig; Gremillet; Amiranoff; Baton; Davies; Hall; Scott; Norreys; Djaoui; Rousseaux; Fews; Bandulet; Pepin

    2000-11-01

    Fast electron generation and propagation were studied in the interaction of a green laser with solids. The experiment, carried out with the LULI TW laser (350 fs, 15 J), used K(alpha) emission from buried fluorescent layers to measure electron transport. Results for conductors (Al) and insulators (plastic) are compared with simulations: in plastic, inhibition in the propagation of fast electrons is observed, due to electric fields which become the dominant factor in electron transport. PMID:11102017

  6. Mesoscale Simulation Data for Initializing Fast-Time Wake Transport and Decay Models

    NASA Technical Reports Server (NTRS)

    Ahmad, Nashat N.; Proctor, Fred H.; Vanvalkenburg, Randal L.; Pruis, Mathew J.; LimonDuparcmeur, Fanny M.

    2012-01-01

    The fast-time wake transport and decay models require vertical profiles of crosswinds, potential temperature and the eddy dissipation rate as initial conditions. These inputs are normally obtained from various field sensors. In case of data-denied scenarios or operational use, these initial conditions can be provided by mesoscale model simulations. In this study, the vertical profiles of potential temperature from a mesoscale model were used as initial conditions for the fast-time wake models. The mesoscale model simulations were compared against available observations and the wake model predictions were compared with the Lidar measurements from three wake vortex field experiments.

  7. Transport of fast electrons in a nanowire array with collisional effects included

    SciTech Connect

    Li, Boyuan; Zhang, Zhimeng; Wang, Jian; Zhang, Bo; Zhao, Zongqing; Shan, Lianqiang; Zhou, Weimin; Zhang, Baohan; Cao, Lihua; Gu, Yuqiu

    2015-12-15

    The transport of picosecond laser generated fast electrons in a nanowire array is studied with two-dimensional particle-in-cell simulations. Our simulations show that a fast electron beam is initially guided and collimated by strong magnetic filaments in the array. Subsequently, after the decomposition of the structure of nanowire array due to plasma expansion, the beam is still collimated by the resistive magnetic field. An analytical model is established to give a criterion for long-term beam collimation in a nanowire array; it indicates that the nanowire cell should be wide enough to keep the beam collimated in picosecond scale.

  8. Fast electron transport and heating in ultraintense laser pulse interaction with solid targets

    NASA Astrophysics Data System (ADS)

    Koenig, Michel; Amiranoff, Francois; Baton, Sophie; Gremillet, Laurent; Martinolli, Emanuele; Batani, Dimitri; Bernardinello, Andrea; Greison, Gabriella; Hall, Tom; Rabec Le Gloahec, Marc; Rousseaux, Christophe; Santos, Joao

    2000-10-01

    In the context of the fast electron transport in solid matter and the fast ignitor scheme, we report on results from ultraintense laser pulse interaction with thick targets. Experiments have been performed at LULI with the 100 TW CPA Nd:glass laser, at intensities up to a few 10^19 W/cm^2. Images obtained from classical and chirped-pulse time-resolved reflectometry diagnostics of the back-side target give evidence of the rear surface heating; the geometry and the dynamics of the energy deposition of the relativistic electrons flux into matter are also inferred.

  9. Oriented assembled TiO2 hierarchical nanowire arrays with fast electron transport properties.

    PubMed

    Sheng, Xia; He, Dongqing; Yang, Jie; Zhu, Kai; Feng, Xinjian

    2014-01-01

    Developing high surface area nanostructured electrodes with rapid charge transport is essential for artificial photosynthesis, solar cells, photocatalysis, and energy storage devices. Substantial research efforts have been recently focused on building one-dimensional (1D) nanoblocks with fast charge transport into three-dimensional (3D) hierarchical architectures. However, except for the enlargement in surface area, there is little experimental evidence of fast electron transport in these 3D nanostructure-based solar cells. In this communication, we report single-crystal-like 3D TiO2 branched nanowire arrays consisting of 1D branch epitaxially grown from the primary trunk. These 3D branched nanoarrays not only demonstrate 71% enlargement in large surface area (compared with 1D nanowire arrays) but also exhibit fast charge transport property (comparable to that in 1D single crystal nanoarrays), leading to 52% improvement in solar conversion efficiency. The orientated 3D assembly strategy reported here can be extended to assemble other metal oxides with one or multiple components and thus represents a critical avenue toward high-performance optoelectronics. PMID:24628675

  10. Effect of MSH/ACTH peptides on fast axonal transport in intact and regenerating sciatic nerves

    SciTech Connect

    Crescitelli, L.A.

    1985-01-01

    Fast axonal transport was examined in intact rats treated with ACTH 4-10 or ACTH 4-9 (ORG 2766), hypophysectomized rats, adrenalectomized rats, and in ACTH 4-10 treated rats with crushed regenerating sciatic nerves by injecting /sup 3/H-leucine into the ventral horn region of the spinal cord. The distance traveled by the transported activity along the sciatic nerve and the rate of fast axonal transport were not significantly altered as a result of treatment with ACTH 4-10, ACTH 4-9 (ORG 2766), hypophysectomy, or adrenalectomy. Treatment with ACTH 4-9 (ORG 2766) at concentrations of 1 ..mu..g/Kg /day and 10 ..mu..g/Kg/day caused significant reductions (62% and 64% respectively) in the crest height of the fast axonal transport curve as compared to 0.9% saline treated control animals. No significant differences were found in comparing the distance, rate, slope, or crest height of ACTH 4-10 treated animals with crushed regenerating (7 or 14d) sciatic nerves to control animals. In the group of animals in days, the amount of radiolabeled activity was significantly increased in the ACTH 4-10 treated animals as compared to control animals. The results indicate that during regeneration the peptide acts to prolong the initially high levels of synthetic activity which occur in regenerating axons.

  11. Integrated kinetic simulation of laser-plasma interactions, fast-electron generation, and transport in fast ignition

    SciTech Connect

    Kemp, A. J.; Cohen, B. I.; Divol, L.

    2010-05-15

    We present new results on the physics of short-pulse laser-matter interaction of kilojoule-picosecond pulses at full spatial and temporal scale using a new approach that combines a three-dimensional collisional electromagnetic particle-in-cell code with a magnetohydrodynamic-hybrid model of high-density plasma. In the latter, collisions damp out plasma waves, and an Ohm's law with electron inertia effects neglected determines the electric field. In addition to yielding orders of magnitude in speed-up while avoiding numerical instabilities, this allows us to model the whole problem in a single unified framework: the laser-plasma interaction at subcritical densities, energy deposition at relativistic critical densities, and fast- electron transport in solid densities. Key questions such as the multipicosecond temporal evolution of the laser energy conversion into hot electrons, the impact of return currents on the laser-plasma interaction, and the effect of self-generated electric and magnetic fields on electron transport will be addressed. We will report applications to current experiments.

  12. Integrated Kinetic Simulation of Laser-Plasma Interactions, Fast-Electron Generation and Transport in Fast Ignition

    SciTech Connect

    Kemp, A; Cohen, B; Divol, L

    2009-11-16

    We present new results on the physics of short-pulse laser-matter interaction of kilojoule-picosecond pulses at full spatial and temporal scale, using a new approach that combines a 3D collisional electromagnetic Particle-in-Cell code with an MHD-hybrid model of high-density plasma. In the latter, collisions damp out plasma waves, and an Ohm's law with electron inertia effects neglected determines the electric field. In addition to yielding orders of magnitude in speed-up while avoiding numerical instabilities, this allows us to model the whole problem in a single unified framework: the laser-plasma interaction at sub-critical densities, energy deposition at relativistic critical densities, and fast-electron transport in solid densities. Key questions such as the multi-picosecond temporal evolution of the laser energy conversion into hot electrons, the impact of return currents on the laser-plasma interaction, and the effect of self-generated electric and magnetic fields on electron transport will be addressed. We will report applications to current experiments.

  13. Study of Fast-Electron Transport in Laser-Illuminated Spherical Targets

    SciTech Connect

    Yaakobi, B.; Gotchev, O.V.; Betti, R.; Stoeckl, C.

    2009-10-22

    The transport and scattering of fast electrons created by the two-plasmon-decay instability are studied by comparing the hard x-ray signal from two identically irradiated targets: a 1-mm-diam solid Cu sphere and a 1-mm-diam solid CH sphere, both coated with a 15 um layer of CH. Comparing the results with Monte Carlo code simulations shows the role of scattering in the higher-Z Cu target. We find evidence that the fast electrons are created with a wide angular divergence and that higher-energy electrons transmitted through the target are reflected back into the target. Because of scattering, the fast-electron energy deposition (preheat) in Cu is about half that in CH, namely, ~0.15% of the laser energy for Cu as compared with ~0.30% for CH. Embedded high-Z layers in imploding fusion targets, because of the scattering, could provide protection against preheat.

  14. Hot electron transport modelling in fast ignition relevant targets with non-Spitzer resistivity

    NASA Astrophysics Data System (ADS)

    Chapman, D. A.; Hughes, S. J.; Hoarty, D. J.; Swatton, D. J. R.

    2010-08-01

    The simple Lee-More model for electrical resistivity is implemented in the hybrid fast electron transport code THOR. The model is shown to reproduce experimental data across a wide range of temperatures using a small number of parameters. The effect of this model on the heating of simple Al targets by a short-pulse laser is studied and compared to the predictions of the classical Spitzer-Härm resistivity. The model is then used in simulations of hot electron transport experiments using buried layer targets.

  15. Evidences for and the Models of Fast Nonlocal Transport of Heat in Magnetic Fusion Devices

    NASA Astrophysics Data System (ADS)

    Kukushkin, A. B.; Cherepanov, K. V.

    2009-07-01

    The paper gives a short survey of (i) recent evidences for fast nonlocal transport of the heat in magnetically confined plasmas (above all, the "cold/heat pulse" experiments), (ii) interpretations of such phenomena in terms of nonlocal transport formalisms, based on the dominance of long mean-free-path energy carriers, including the interpretations of "cold pulse" experiments, and gives (iii) quantitative evidence for the domination of nonlocality in the spatial profile of electron cyclotron net radiated power in fusion reactor-grade tokamak (strong toroidal magnetic field, BT>5 T, highly reflecting walls, Rwall>0.5, and hot electron plasma, >10 keV).

  16. PIC modeling of material dependence on fast electron generation and transport

    NASA Astrophysics Data System (ADS)

    Mishra, R.; Wei, M. S.; Chawla, S.; Sentoku, Y.; Stephens, R. B.; Beg, F. N.

    2011-10-01

    2D collisional PIC simulations, using PICLS code that includes dynamic ionization and radiation cooling, are performed to model a recent experiment on the Titan laser using multi-foil targets, where 2x reduction in total fast electron flux and a smaller spot size through high-Z layer were observed. Modeling show that a thin high-Z transport layer (e.g., Au) near lower Z source layer introduces a collimating effect on fast electron transport. Strong self-generated resistive B-fields are produced inside Au layer and at the interface (Al/Au), which confine the fast electron propagation and can also trap electrons in wing region to inhibit their propagation. In addition, effects of the surface material on LPI produced fast electron source characteristics are examined in both planar and buried cone geometries. Supported by US DOE under contracts DE-AC52 07NA27344(ACE) and DE-FC02-04ER54789 (FSC).

  17. Fast Monte Carlo Electron-Photon Transport Method and Application in Accurate Radiotherapy

    NASA Astrophysics Data System (ADS)

    Hao, Lijuan; Sun, Guangyao; Zheng, Huaqing; Song, Jing; Chen, Zhenping; Li, Gui

    2014-06-01

    Monte Carlo (MC) method is the most accurate computational method for dose calculation, but its wide application on clinical accurate radiotherapy is hindered due to its poor speed of converging and long computation time. In the MC dose calculation research, the main task is to speed up computation while high precision is maintained. The purpose of this paper is to enhance the calculation speed of MC method for electron-photon transport with high precision and ultimately to reduce the accurate radiotherapy dose calculation time based on normal computer to the level of several hours, which meets the requirement of clinical dose verification. Based on the existing Super Monte Carlo Simulation Program (SuperMC), developed by FDS Team, a fast MC method for electron-photon coupled transport was presented with focus on two aspects: firstly, through simplifying and optimizing the physical model of the electron-photon transport, the calculation speed was increased with slightly reduction of calculation accuracy; secondly, using a variety of MC calculation acceleration methods, for example, taking use of obtained information in previous calculations to avoid repeat simulation of particles with identical history; applying proper variance reduction techniques to accelerate MC method convergence rate, etc. The fast MC method was tested by a lot of simple physical models and clinical cases included nasopharyngeal carcinoma, peripheral lung tumor, cervical carcinoma, etc. The result shows that the fast MC method for electron-photon transport was fast enough to meet the requirement of clinical accurate radiotherapy dose verification. Later, the method will be applied to the Accurate/Advanced Radiation Therapy System ARTS as a MC dose verification module.

  18. Simulations of electron transport and ignition for direct-drive fast-ignition targets

    NASA Astrophysics Data System (ADS)

    Solodov, A. A.; Anderson, K. S.; Betti, R.; Gotcheva, V.; Myatt, J.; Delettrez, J. A.; Skupsky, S.; Theobald, W.; Stoeckl, C.

    2008-11-01

    The performance of high-gain, fast-ignition fusion targets is investigated using one-dimensional hydrodynamic simulations of implosion and two-dimensional (2D) hybrid fluid-particle simulations of hot-electron transport, ignition, and burn. The 2D/3D hybrid-particle-in-cell code LSP [D. R. Welch et al., Nucl. Instrum. Methods Phys. Res. A 464, 134 (2001)] and the 2D fluid code DRACO [P. B. Radha et al., Phys. Plasmas 12, 056307 (2005)] are integrated to simulate the hot-electron transport and heating for direct-drive fast-ignition targets. LSP simulates the transport of hot electrons from the place where they are generated to the dense fuel core where their energy is absorbed. DRACO includes the physics required to simulate compression, ignition, and burn of fast-ignition targets. The self-generated resistive magnetic field is found to collimate the hot-electron beam, increase the coupling efficiency of hot electrons with the target, and reduce the minimum energy required for ignition. Resistive filamentation of the hot-electron beam is also observed. The minimum energy required for ignition is found for hot electrons with realistic angular spread and Maxwellian energy-distribution function.

  19. Electron Generation and Transport in Intense Relativistic Laser-Plasma Interactions Relevant to Fast Ignition ICF

    SciTech Connect

    Ma, Tammy Yee Wing

    2010-01-01

    The reentrant cone approach to Fast Ignition, an advanced Inertial Confinement Fusion scheme, remains one of the most attractive because of the potential to efficiently collect and guide the laser light into the cone tip and direct energetic electrons into the high density core of the fuel. However, in the presence of a preformed plasma, the laser energy is largely absorbed before it can reach the cone tip. Full scale fast ignition laser systems are envisioned to have prepulses ranging between 100 mJ to 1 J. A few of the imperative issues facing fast ignition, then, are the conversion efficiency with which the laser light is converted to hot electrons, the subsequent transport characteristics of those electrons, and requirements for maximum allowable prepulse this may put on the laser system. This dissertation examines the laser-to-fast electron conversion efficiency scaling with prepulse for cone-guided fast ignition. Work in developing an extreme ultraviolet imager diagnostic for the temperature measurements of electron-heated targets, as well as the validation of the use of a thin wire for simultaneous determination of electron number density and electron temperature will be discussed.

  20. Transport simulation and image reconstruction for fast-neutron detection of explosives and narcotics

    SciTech Connect

    Micklich, B.J.; Fink, C.L.; Sagalovsky, L.

    1995-07-01

    Fast-neutron inspection techniques show considerable promise for explosive and narcotics detection. A key advantage of using fast neutrons is their sensitivity to low-Z elements (carbon, nitrogen, and oxygen), which are the primary constituents of these materials. We are currently investigating two interrogation methods in detail: Fast-Neutron Transmission Spectroscopy (FNTS) and Pulsed Fast-Neutron Analysis (PFNA). FNTS is being studied for explosives and narcotics detection in luggage and small containers for which the transmission ratio is greater than about 0.01. The Monte-Carlo radiation transport code MCNP is being used to simulate neutron transmission through a series of phantoms for a few (3-5) projection angles and modest (2 cm) resolution. Areal densities along projection rays are unfolded from the transmission data. Elemental abundances are obtained for individual voxels by tomographic reconstruction, and these reconstructed elemental images are combined to provide indications of the presence or absence of explosives or narcotics. PFNA techniques are being investigated for detection of narcotics in cargo containers because of the good penetration of the fast neutrons and the low attenuation of the resulting high-energy gamma-ray signatures. Analytic models and Monte-Carlo simulations are being used to explore the range of capabilities of PFNA techniques and to provide insight into systems engineering issues. Results of studies from both FNTS and PFNA techniques are presented.

  1. Transport simulation and image reconstruction for fast-neutron detection of explosives and narcotics

    NASA Astrophysics Data System (ADS)

    Micklich, Bradley J.; Fink, Charles L.; Sagalovsky, Leonid

    1995-09-01

    Fast-neutron inspection techniques show considerable promise for explosive and narcotics detection. A key advantage of using fast neutron is their sensitivity to low-Z elements (carbon, nitrogen, and oxygen), which are the primary constituents of these materials. We are currently investigating two interrogation methods in detail: fast-neutron transmission spectroscopy (FNTS) and pulsed fast-neutron analysis (PFNA). FNTS is being studied for explosives and narcotics detection in luggage and small containers for which the transmission ration is greater than about 0.01. The Monte Carlo radiation transport code MCNP is being used to simulate neutron transmission through a series of phantoms for a few (3-5) projections angles and modest (2 cm) reolution. Areal densities along projection rays are unfolded from the transmission data. Elemental abundances are obtained for individual voxels by tomographic reconstruction, and the reconstructed elemental images are combined to provide indications of the presence or absence of explosives or narcotics. PFNA techniques are being investigated for detection of narcotics in cargo containers because of the good penetration of the fast neutrons and the low attenuation of the resulting high-energy gamma-ray signatures. Analytic models and Monte Carlo simulations are being used to explore the range of capabilities of PFNA techniques and to provide insight into systems engineering issues. Results of studies from both FNTS and PFNA technqiues are presented.

  2. Carbon transport in a bimetallic sodium loop simulating the intermediate heat transport system of a liquid metal fast breeder reactor

    SciTech Connect

    Hampton, L.V.; Spalaris, C.N.; Roy, P.

    1980-04-01

    Carbon transport data from a bimetallic sodium loop simulating the intermediate heat transport system of a Liquid Metal Fast Breeder Reactor are discussed. The results of bulk carbon analyses after 15,000 hours' exposure indicate a pattern of carburization of Type 304 stainless steel foils which is independent of loop sodium temperature. A model based on carbon activity gradients accounting for this behavior is proposed. Data also indicate that carburization of Type 304 stainless steel is a diffusion-controlled process; however, decarburization of the ferritic 2 1/4 Cr-1Mo steel is not. It is proposed that the decarburization of the ferritic steel is controlled by the dissolution of carbides in the steel matrix. The differences in the sodium decarburization behavior of electroslag remelted and vacuum-arc remelted 2 1/4 Cr-1Mo steel are also highlighted.

  3. Integrated simulations of implosion, electron transport, and heating for direct-drive fast-ignition targetsa)

    NASA Astrophysics Data System (ADS)

    Solodov, A. A.; Anderson, K. S.; Betti, R.; Gotcheva, V.; Myatt, J.; Delettrez, J. A.; Skupsky, S.; Theobald, W.; Stoeckl, C.

    2009-05-01

    A thorough understanding of future integrated fast-ignition experiments combining compression and heating of high-density thermonuclear fuel requires hybrid (fluid+particle) simulations of the implosion and ignition process. Different spatial and temporal scales need to be resolved to model the entire fast-ignition experiment. The two-dimensional (2D) axisymmetric hydrocode DRACO [P. B. Radha et al., Phys. Plasmas 12, 056307 (2005)] and the 2D/three-dimensional hybrid particle-in-cell code LSP [D. R. Welch et al., Nucl. Instrum. Methods Phys. Res. A 464, 134 (2001)] have been integrated to simulate the implosion and heating of direct-drive, fast-ignition fusion targets. DRACO includes the physics required to simulate compression, ignition, and burn of fast-ignition targets. LSP simulates the transport of hot electrons from the place where they are generated to the dense fuel core where their energy is absorbed. The results from integrated simulations of cone-in-shell CD targets designed for fast-ignition experiments on OMEGA [T. R. Boehly et al., Opt. Commun. 133, 495 (1997); C. Stoeckl et al., Fusion Sci. Technol. 49, 367 (2006)] are presented. Target heating and neutron yields are computed. The results from LSP simulations of electron transport in solid-density plastic targets are also presented. They confirm an increase in the electron divergence angle with the laser intensity in the current experiments. The self-generated resistive magnetic field is found to collimate the hot-electron beam and increase the coupling efficiency of hot electrons with the target. Resistive filamentation of the hot-electron beam is also observed.

  4. A fast low-pressure transport route to large black phosphorus single crystals

    SciTech Connect

    Nilges, Tom Kersting, Marcel; Pfeifer, Thorben

    2008-08-15

    Black phosphorus, a promising candidate for lithium battery electrodes, can be prepared by a low-pressure transport reaction route representing the first effective and scalable access to this element modification. Crystal sizes larger than 1 cm were obtained at low-pressure conditions in silica ampoules. X-ray phase analyses, EDX, ICP-MS and optical microscopy were applied to characterize the resulting black phosphorus. The present method drastically improves the traditional preparation ways like mercury catalysis, bismuth-flux or high-pressure techniques and represents an easy, non-toxic, fast and highly efficient method to achieve black phosphorus. In contrast to a previously reported low-pressure route the present transport reaction allows an up-scaling to higher masses of starting materials, a larger black phosphorus yield and faster reaction time under retention of the high product crystallinity. - Graphical abstract: A low-pressure transport reaction route representing the first effective and scalable access to black phosphorus.

  5. Observation of Critical-Gradient Behavior in Alfvén-Eigenmode-Induced Fast-Ion Transport

    NASA Astrophysics Data System (ADS)

    Collins, C. S.; Heidbrink, W. W.; Austin, M. E.; Kramer, G. J.; Pace, D. C.; Petty, C. C.; Stagner, L.; Van Zeeland, M. A.; White, R. B.; Zhu, Y. B.

    2016-03-01

    Experiments in the DIII-D tokamak show that fast-ion transport suddenly becomes stiff above a critical threshold in the presence of many overlapping small-amplitude Alfvén eigenmodes (AEs). The threshold is phase-space dependent and occurs when particle orbits become stochastic due to resonances with AEs. Above threshold, equilibrium fast-ion density profiles are unchanged despite increased drive, and intermittent fast-ion losses are observed. Fast-ion D α spectroscopy indicates radially localized transport of the copassing population at radii that correspond to the location of midcore AEs. The observation of stiff fast-ion transport suggests that reduced models can be used to effectively predict alpha profiles, beam ion profiles, and losses to aid in the design of optimized scenarios for future burning plasma devices.

  6. Observation of Critical-Gradient Behavior in Alfvén-Eigenmode-Induced Fast-Ion Transport.

    PubMed

    Collins, C S; Heidbrink, W W; Austin, M E; Kramer, G J; Pace, D C; Petty, C C; Stagner, L; Van Zeeland, M A; White, R B; Zhu, Y B

    2016-03-01

    Experiments in the DIII-D tokamak show that fast-ion transport suddenly becomes stiff above a critical threshold in the presence of many overlapping small-amplitude Alfvén eigenmodes (AEs). The threshold is phase-space dependent and occurs when particle orbits become stochastic due to resonances with AEs. Above threshold, equilibrium fast-ion density profiles are unchanged despite increased drive, and intermittent fast-ion losses are observed. Fast-ion Dα spectroscopy indicates radially localized transport of the copassing population at radii that correspond to the location of midcore AEs. The observation of stiff fast-ion transport suggests that reduced models can be used to effectively predict alpha profiles, beam ion profiles, and losses to aid in the design of optimized scenarios for future burning plasma devices. PMID:26991180

  7. Quantum transport in neutron-irradiated modulation-doped heterojunctions. I. Fast neutrons

    SciTech Connect

    Jin, W.; Zhou, J.; Huang, Y.; Cai, L.

    1988-12-15

    We have investigated the characteristics of low-temperature quantum transport in Al/sub x/Ga/sub 1-//sub x/As/GaAs modulation-doped heterojunctions irradiated by fast neutrons of about 14 MeV energy. The concentration and the mobility of the two-dimensional electron gas (2D EG) under low magnetic fields decrease with increase in the concentrations of scatterers, such as ionized impurities, lattice defects, and interface roughness. On the other hand, under strong magnetic fields, the Hall plateau broadening associated with the Landau localized states, and the Shubnikov--de Hass (SdH) oscillation enhancement associated with the Landau extended states, increase markedly after fast-neutron irradiation.

  8. A fast Monte Carlo code for proton transport in radiation therapy based on MCNPX

    PubMed Central

    Jabbari, Keyvan; Seuntjens, Jan

    2014-01-01

    An important requirement for proton therapy is a software for dose calculation. Monte Carlo is the most accurate method for dose calculation, but it is very slow. In this work, a method is developed to improve the speed of dose calculation. The method is based on pre-generated tracks for particle transport. The MCNPX code has been used for generation of tracks. A set of data including the track of the particle was produced in each particular material (water, air, lung tissue, bone, and soft tissue). This code can transport protons in wide range of energies (up to 200 MeV for proton). The validity of the fast Monte Carlo (MC) code is evaluated with data MCNPX as a reference code. While analytical pencil beam algorithm transport shows great errors (up to 10%) near small high density heterogeneities, there was less than 2% deviation of MCNPX results in our dose calculation and isodose distribution. In terms of speed, the code runs 200 times faster than MCNPX. In the Fast MC code which is developed in this work, it takes the system less than 2 minutes to calculate dose for 106 particles in an Intel Core 2 Duo 2.66 GHZ desktop computer. PMID:25190994

  9. The Effects of the Initial Electron Distribution on Fast Ignition Relevant Transport Experiments

    NASA Astrophysics Data System (ADS)

    Cottrill, L.; Key, M. H.; Lasinski, B. F.; Tabak, M.; Town, R. P. J.; Wilks, S. C.; Welch, D. R.

    2003-10-01

    One of the essential issues necessary for understanding the physics surrounding the Fast Ignition concept [1] consists of the characterization of the energy transport within a dense plasma. Experiments have sought to characterize this transport through the interaction of short pulse, high intensity lasers with solid-density thin targets using Kα fluorescence layers [2]. We report on LSP calculations of these experiments. The LSP code uses a direct implicit particle-in-cell algorithm in 2 or 3 dimensions to solve for beam particle transport, while treating the background particles as a fluid [3]. The effects of multidimensional source representation within the code, as well as alternative hot electron beam temperature scalings, will be presented, along with their implications for fast ignition. This work was performed under the auspices of the U.S. Department of Energy by the University of California, Lawrence Livermore National Laboratory under contract W- 7405-ENG-48. [1] M. Tabak, et al, Phys. Plasmas 1, 1626 (1994). [2] R.B. Stephens, et al, submitted to Phys. Rev. E. [3] D.R. Welch, et al, Nucl. Inst. Meth. Phys. Res. A 242, 134 (2001).

  10. Fast Responsive and Controllable Liquid Transport on a Magnetic Fluid/Nanoarray Composite Interface.

    PubMed

    Tian, Dongliang; Zhang, Na; Zheng, Xi; Hou, Guanglei; Tian, Ye; Du, Yi; Jiang, Lei; Dou, Shi Xue

    2016-06-28

    Controllable liquid transport on surface is expected to occur by manipulating the gradient of surface tension/Laplace pressure and external stimuli, which has been intensively studied on solid or liquid interface. However, it still faces challenges of slow response rate, and uncontrollable transport speed and direction. Here, we demonstrate fast responsive and controllable liquid transport on a smart magnetic fluid/nanoarray interface, i.e., a composite interface, via modulation of an external magnetic field. The wettability of the composite interface to water instantaneously responds to gradient magnetic field due to the magnetically driven composite interface gradient roughness transition that takes place within a millisecond, which is at least 1 order of magnitude faster than that of other responsive surfaces. A water droplet can follow the motion of the gradient composite interface structure as it responds to the gradient magnetic field motion. Moreover, the water droplet transport direction can be controlled by modulating the motion direction of the gradient magnetic field. The composite interface can be used as a pump for the transport of immiscible liquids and other objects in the microchannel, which suggests a way to design smart interface materials and microfluidic devices. PMID:27199104

  11. Molecular-Flow Properties of RIB Type Vapor-Transport Systems Using a Fast-Valve

    SciTech Connect

    Alton, Gerald D; Bilheux, Hassina Z; Zhang, Y.; Liu, Yuan

    2014-01-01

    The advent of the fast-valve device, described previously, permits measurement of molecular-flow times of chemically active or inactive gaseous species through radioactive ion beam (RIB) target ion source systems, independent of size, geometry and materials of construction. Thus, decay losses of short-half-life RIBs can be determined for a given target/vapor-transport system in advance of on-line operation, thereby ascertaining the feasibility of the system design for successful processing of a given isotope. In this article, molecular-flow-time theory and experimentally measured molecular-flow time data are given for serial- and parallel-coupled Ta metal RIB vapor-transport systems similar to those used at ISOL based RIB facilities. In addition, the effect of source type on the molecular-flow time properties of a given system is addressed, and a chemical passivation method for negating surface adsorption enthalpies for chemically active gaseous species on Ta surfaces is demonstrated.

  12. Theory of ion transport with fast acid-base equilibrations in bioelectrochemical systems

    NASA Astrophysics Data System (ADS)

    Dykstra, J. E.; Biesheuvel, P. M.; Bruning, H.; Ter Heijne, A.

    2014-07-01

    Bioelectrochemical systems recover valuable components and energy in the form of hydrogen or electricity from aqueous organic streams. We derive a one-dimensional steady-state model for ion transport in a bioelectrochemical system, with the ions subject to diffusional and electrical forces. Since most of the ionic species can undergo acid-base reactions, ion transport is combined in our model with infinitely fast ion acid-base equilibrations. The model describes the current-induced ammonia evaporation and recovery at the cathode side of a bioelectrochemical system that runs on an organic stream containing ammonium ions. We identify that the rate of ammonia evaporation depends not only on the current but also on the flow rate of gas in the cathode chamber, the diffusion of ammonia from the cathode back into the anode chamber, through the ion exchange membrane placed in between, and the membrane charge density.

  13. Theory of ion transport with fast acid-base equilibrations in bioelectrochemical systems.

    PubMed

    Dykstra, J E; Biesheuvel, P M; Bruning, H; Ter Heijne, A

    2014-07-01

    Bioelectrochemical systems recover valuable components and energy in the form of hydrogen or electricity from aqueous organic streams. We derive a one-dimensional steady-state model for ion transport in a bioelectrochemical system, with the ions subject to diffusional and electrical forces. Since most of the ionic species can undergo acid-base reactions, ion transport is combined in our model with infinitely fast ion acid-base equilibrations. The model describes the current-induced ammonia evaporation and recovery at the cathode side of a bioelectrochemical system that runs on an organic stream containing ammonium ions. We identify that the rate of ammonia evaporation depends not only on the current but also on the flow rate of gas in the cathode chamber, the diffusion of ammonia from the cathode back into the anode chamber, through the ion exchange membrane placed in between, and the membrane charge density. PMID:25122405

  14. Fast strontium transport induced by hydrodynamic dispersion and pH-dependent sorption

    NASA Astrophysics Data System (ADS)

    Prigiobbe, Valentina; Hesse, Marc A.; Bryant, Steven L.

    2012-09-01

    As a fluid carries solutes through a porous material, species that sorb onto the surface of the material travel more slowly than the fluid. Stronger adsorption results in slower solute migration, or increased solute retardation. The adsorption of strontium (Sr2+) onto iron-oxides is strongly pH-dependent and becomes significant at high pH. Radioactive Sr2+ isotopes are, therefore, commonly stored in alkaline solutions to maximize their retardation. Field observations and numerical simulations of the leakage of such solutions into low-pH soils, however, show that even Sr2+ stored in alkaline solutions can migrate without retardation. Migration occurs because hydrodynamic dispersion allows mixing of Sr2+ with the low-pH fluid forming an acidic Sr2+-rich plume which can travel without retardation. Here we report the first experimental observations confirming this dispersion-induced fast Sr2+ transport. We report column-flood experiments where a high-pH solution containing Sr2+ was injected into a low-pH porous medium of iron-oxide-coated beads. We observe both a strongly retarded Sr2+ front and an isolated fast pulse of Sr2+ traveling at the average fluid velocity. This dispersion-induced fast pulse of strontium must be taken into account when considering the safety of radionuclide storage in alkaline solutions.

  15. Alfv?nic Instabilities and Fast Ion Transport in the DIII-D Tokamak

    SciTech Connect

    Van Zeeland, M; Heidbrink, W; Nazikian, R; Austin, M; Berk, H; Gorelenkov, N; Holcomb, C; Kramer, G; Lohr, J; Luo, Y; Makowski, M; McKee, G; Petty, C; Prater, R; Solomon, W; White, R

    2008-10-14

    Neutral beam injection into reversed magnetic shear DIII-D plasmas produces a variety of Alfvenic activity including Toroidicity and Ellipticity induced Alfven Eigenmodes (TAE/EAE, respectively) and Reversed Shear Alfven Eigenmodes (RSAE) as well as their spatial coupling. These modes are typically studied during the discharge current ramp phase when incomplete current penetration results in a high central safety factor and strong drive due to multiple higher order resonances. During this same time period Fast-Ion D{sub {alpha}} (FIDA) spectroscopy shows that the central fast ion profile is flattened, the degree of which depends on the Alfven eigenmode amplitude. Interestingly, localized electron cyclotron heating (ECH) near the mode location stabilizes RSAE activity and results in significantly improved fast ion confinement relative to discharges with ECH deposition on axis. In these discharges, RSAE activity is suppressed when ECH is deposited near the radius of the shear reversal point and enhanced with deposition near the axis. To simulate the observed neutral beam ion redistribution, NOVA calculations of the 3D eigenmode structures are matched with experimental measurements and used in combination with the ORBIT guiding center following code. For fixed frequency eigenmodes, it is found that ORBIT calculations cannot explain the observed beam ion transport with experimentally measured mode amplitudes. Possible explanations are considered including recent simulation results incorporating eigenmodes with time dependent frequencies.

  16. A fast and robust method for automated analysis of axonal transport.

    PubMed

    Welzel, Oliver; Knörr, Jutta; Stroebel, Armin M; Kornhuber, Johannes; Groemer, Teja W

    2011-09-01

    Cargo movement along axons and dendrites is indispensable for the survival and maintenance of neuronal networks. Key parameters of this transport such as particle velocities and pausing times are often studied using kymograph construction, which converts the transport along a line of interest from a time-lapse movie into a position versus time image. Here we present a method for the automatic analysis of such kymographs based on the Hough transform, which is a robust and fast technique to extract lines from images. The applicability of the method was tested on simulated kymograph images and real data from axonal transport of synaptophysin and tetanus toxin as well as the velocity analysis of synaptic vesicle sharing between adjacent synapses in hippocampal neurons. Efficiency analysis revealed that the algorithm is able to detect a wide range of velocities and can be used at low signal-to-noise ratios. The present work enables the quantification of axonal transport parameters with high throughput with no a priori assumptions and minimal human intervention. PMID:21695534

  17. Modeling fast-ion transport during toroidal Alfven eigenmode avalanches in National Spherical Torus Experiment

    SciTech Connect

    Fredrickson, E. D.; Bell, R. E.; Darrow, D. S.; Gorelenkov, N. N.; Kramer, G. J.; Medley, S. S.; White, R. B.; Crocker, N. A.; Kubota, S.; Levinton, F. M.; Yuh, H.; Liu, D.; Podesta, M.; Tritz, K.

    2009-12-15

    Experiments on the National Spherical Torus Experiment [M. Ono et al., Nucl. Fusion 40, 557 (2000)] found strong bursts of toroidal Alfven eigenmode (TAE) activity correlated with abrupt drops in the neutron rate. A fairly complete data set offers the opportunity to benchmark the NOVA[C. Z. Cheng, Phys. Rep. 211, 1 (1992)] and ORBIT[R. B. White and M. S. Chance, Phys. Fluids 27, 2455 (1984)] codes in the low aspect ratio tokamak (ST) geometry. The internal structure of TAE was modeled with NOVA and good agreement is found with measurements made with an array of five fixed-frequency reflectometers. The fast-ion transport resulting from these bursts of multiple TAE was then modeled with the ORBIT code. The simulations are reasonably consistent with the observed drop in neutron rate, however, further refinements in both the simulation of the TAE structure and in the modeling of the fast-ion transport are needed. Benchmarking stability codes against present experiments is an important step in developing the predictive capability needed to plan future experiments.

  18. Measurements of Fast-Ion Transport by Resonant Interaction at a Sawtooth Crash

    NASA Astrophysics Data System (ADS)

    Muscatello, C. M.; Heidbrink, W. W.

    2011-10-01

    Tokamak sawteeth consist of a reorganization of the plasma magnetic field and various plasma parameters. Observations indicate that distributions of superthermal ions can also be affected at the crash event. The bulk of energetic ions experiencing redistribution have passing orbits and low to moderate energies (<=100 keV) where transport due to flux-attachment is valid. Sawtooth experiments at DIII-D employing the fast-ion deuterium-alpha (FIDA) diagnostic suite indicate that even high-energy ions (>100 keV) can experience appreciable redistribution. The transport mechanism, in this case, is different; a class of trapped particles with near zero toroidal precession velocity and narrow orbit width can satisfy the nonlinear wave-particle resonance condition. Trapped within the magnetic well of the helical perturbation, the particle transforms to a ``superbanana'' orbit through the resonant interaction. The effect manifests as a plateau in the trapped fast-ion profile at the resonance layer. Work supported by the US DOE under SC-G903402 and DE-FC02-04ER54698.

  19. Generation and Transport of Fast Electrons in Laser Irradiated Targets at Relativistic Intensities

    NASA Astrophysics Data System (ADS)

    Amiranoff, F.; Baton, S. D.; Gremillet, L.; Guilbaud, O.; Koenig, M.; Martinolli, E.; Santos, J. J.; Le Gloahec, M. Rabec; Rousseaux, C.; Hall, T.

    2002-10-01

    The transport of relativistic electrons in solid targets irradiated by a short laser pulse at relativistic intensities has been studied both experimentally and numerically. A Monte-Carlo collision code takes into account individual collisions with the ions and electrons in the target. A 3D-hybrid code takes into account these collisions as well as the generation of electric and magnetic fields and the self-consistent motion of the electrons in these fields. It predicts a magnetic guiding of a fraction of the fast electron current over long distances and a localized heating of the material along the propagation axis. In experiments performed at LULI on the 100 TW laser facility, several diagnostics have been implemented to diagnose the geometry of the fast electron transport and the target heating. The typical conditions were: E1 less-than-or-equal 20 J, lambda = 1 mum, tau approximately 300 fs, I approximately 1018-5.1019W/cm2. The results indicate a modest heating of the target (typically 20-40 eV over 20 mum to 50 mum), consistent with an acceleration of the electrons inside a wide aperture cone along the laser axis.

  20. Fast particle generation and energy transport in laser-solid interactions

    NASA Astrophysics Data System (ADS)

    Zepf, Matthew

    2000-10-01

    The generation and propagation of fast electrons is a topic of intense research not least due to its relevance to the Fast Ignitor Scheme [1, 2, 3]. More recently a lot of attention has also focused on the production of highly energetic protons [3,4, 5] which are observed at the rear of the target. Apart from a possible role in a modified Fast Ignitor scenario these are also of interest for generating radioactive isotopes via nuclear reactions and as a probe. We present results from a recent experimental campaign using the Vulcan (70 TW) laser at the Rutherford Appleton Laboratory. Using innovative nuclear activation techniques and CR-39 track detectors, the angular and energy distribution of the protons for a range of different targets and intensities has been measured. Various electron acceleration mechanisms are known, both in the underdense region and at the critical density surface. It is vital to understand their interplay in these complex interactions. The subsequent propagation of the electron beams through the overdense plasma is also of great importance. Since the currents generated far exceed the Alfven limit, the fast electron current needs to be almost perfectly compensated. The transport and energy deposition is therefore expected to be dominated by collective effects rather than the single electron scattering stopping range. We will show recent results showing the dependence of electron beam directionality, generation mechanism and energy deposition on a range of laser parameters. [1] M. Tabak et al., Phys. Plasmas 1, pp.1626 (1994) [2] M. Santala et al., Phys. Rev. Lett 84, pp. 1459 (2000) [3] Hatchett et al., Phys. Plasmas 7, pp. 2076 (2000) [4] E. Clark et al., Phys. Rev. Lett., 84, pp. 670 (2000) [5] A. Maksimchuk et al. Phys, Rev. Lett 84, pp. 4108 (2000)

  1. Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha.

    PubMed

    Dietrich, Christoph G; Martin, Ina V; Porn, Anne C; Voigt, Sebastian; Gartung, Carsten; Trautwein, Christian; Geier, Andreas

    2007-09-01

    Fasting induces numerous adaptive changes in metabolism by several central signaling pathways, the most important represented by the HNF4alpha/PGC-1alpha-pathway. Because HNF4alpha has been identified as central regulator of basolateral bile acid transporters and a previous study reports increased basolateral bile acid uptake into the liver during fasting, we hypothesized that HNF4alpha is involved in fasting-induced bile acid uptake via upregulation of basolateral bile acid transporters. In rats, mRNA of Ntcp, Oatp1, and Oatp2 were significantly increased after 48 h of fasting. Protein expression as determined by Western blot showed significant increases for all three transporters 72 h after the onset of fasting. Whereas binding activity of HNF1alpha in electrophoretic mobility shift assays remained unchanged, HNF4alpha binding activity to the Ntcp promoter was increased significantly. In line with this result, we found significantly increased mRNA expression of HNF4alpha and PGC-1alpha. Functional studies in HepG2 cells revealed an increased endogenous NTCP mRNA expression upon cotransfection with either HNF4alpha, PGC-1alpha, or a combination of both. We conclude that upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway. PMID:17640976

  2. A study of fast electron energy transport in relativistically intense laser-plasma interactions with large density scalelengths

    SciTech Connect

    Scott, R. H. H.; Norreys, P. A.; Perez, F.; Baton, S. D.; Davies, J. R.; Lancaster, K. L.; Trines, R. M. G. M.; Bell, A. R.; Tzoufras, M.; Rose, S. J.

    2012-05-15

    A systematic experimental and computational investigation of the effects of three well characterized density scalelengths on fast electron energy transport in ultra-intense laser-solid interactions has been performed. Experimental evidence is presented which shows that, when the density scalelength is sufficiently large, the fast electron beam entering the solid-density plasma is best described by two distinct populations: those accelerated within the coronal plasma (the fast electron pre-beam) and those accelerated near or at the critical density surface (the fast electron main-beam). The former has considerably lower divergence and higher temperature than that of the main-beam with a half-angle of {approx}20 Degree-Sign . It contains up to 30% of the total fast electron energy absorbed into the target. The number, kinetic energy, and total energy of the fast electrons in the pre-beam are increased by an increase in density scalelength. With larger density scalelengths, the fast electrons heat a smaller cross sectional area of the target, causing the thinnest targets to reach significantly higher rear surface temperatures. Modelling indicates that the enhanced fast electron pre-beam associated with the large density scalelength interaction generates a magnetic field within the target of sufficient magnitude to partially collimate the subsequent, more divergent, fast electron main-beam.

  3. Calculations of fast electron transport through different materials at solid density using a robust hybrid code

    NASA Astrophysics Data System (ADS)

    Hughes, Steve; Chapman, David

    2009-11-01

    Development of a robust hybrid code is useful for efficient calculation of fast electron transport, in conjunction with a radiation hydrodynamics code. The code THOR has been developed for coupling to a fluid code in this fashion for modelling this fast electron population generated during short-pulse laser experiments. It is built on the hybrid philosophy of work by J.R. Davies, which provides an intuitive and relatively straightforward computational framework, and makes it easier to take advantage of parallelism for reducing noise in the solution. The basic algorithms of the code are described along with the approximations and limitations of the current implementation. Recent experiments by D. Hoarty at AWE have demonstrated a method of heating solid density Aluminium layers to hundreds of eV, buried at various depths in a plastic target. Application of the THOR code in reproducing these measurements is shown with encouraging results. The quality of the match to the data is discussed with layers placed at various depths as in the experiments, and with different laser sources. The problems of comparing the code outputs with the measurement technique used in the experiment are also described.

  4. Ultra-fast single-file transport of a simple liquid beyond the collective behavior zone.

    PubMed

    Su, Jiaye; Yang, Keda; Huang, Decai

    2016-07-27

    We use molecular dynamics simulations to analyze the single-file transport behavior of a simple liquid through a narrow membrane channel. With the decrease of the liquid-channel interaction, the liquid flow exhibits a remarkable maximum behavior owing to the competition of liquid-liquid and liquid-channel interactions. Surprisingly, this maximum flow is coupled to a sudden reduce of the liquid occupancy, where the liquid particle is moving through the channel alone at nearly constant velocity, rather than in a collective motion mode. Further investigation on the encountered energy barrier suggests that this maximum flow should be induced by particles having large instant velocities (or thermal fluctuation) that overcome the liquid-liquid and liquid-channel interaction barriers. Further decreasing the liquid-channel interaction leads to the decrease and ultimate stabilization of the liquid flow, since the energy barrier will increase and becomes steady. These results suggest that the breakdown of collective behavior can be a new rule for achieving fast single-file transportation, especially for simple or nonpolar liquids with relatively weak liquid-liquid interactions, and is thus helpful for the design of high flux nanofluidic devices. PMID:27460013

  5. Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

    PubMed Central

    Pigino, G.; Morfini, G.; Atagi, Y.; Deshpande, A.; Yu, C.; Jungbauer, L.; LaDu, M.; Busciglio, J.; Brady, S.

    2009-01-01

    The pathological mechanism by which Aβ causes neuronal dysfunction and death remains largely unknown. Deficiencies in fast axonal transport (FAT) were suggested to play a crucial role in neuronal dysfunction and loss for a diverse set of dying back neuropathologies including Alzheimer's disease (AD), but the molecular basis for pathological changes in FAT were undetermined. Recent findings indicate that soluble intracellular oligomeric Aβ (oAβ) species may play a critical role in AD pathology. Real-time analysis of vesicle mobility in isolated axoplasms perfused with oAβ showed bidirectional axonal transport inhibition as a consequence of endogenous casein kinase 2 (CK2) activation. Conversely, neither unaggregated amyloid beta nor fibrillar amyloid beta affected FAT. Inhibition of FAT by oAβ was prevented by two specific pharmacological inhibitors of CK2, as well as by competition with a CK2 substrate peptide. Furthermore, perfusion of axoplasms with active CK2 mimics the inhibitory effects of oAβ on FAT. Both oAβ and CK2 treatment of axoplasm led to increased phosphorylation of kinesin-1 light chains and subsequent release of kinesin from its cargoes. Therefore pharmacological modulation of CK2 activity may represent a promising target for therapeutic intervention in AD. PMID:19321417

  6. Structural and fast ion transport properties of glassy and amorphous materials

    SciTech Connect

    Whitmore, D.H.; Georgopoulos, P.

    1989-11-01

    This research has dealt with ionic conductivity in two classes of electrolytes. Solid inorganic, as well as polymer. In the former case, a structural characterization study of the fast Ag{sup +} ion conducting glassy electrolyte Ag{sub 0.25}Ge{sub 0.19}Se{sub 0.56} was undertaken by means of differential anomalous x-ray scattering techniques. The Ag{sup +} ion transport behavior was probed with the aid of complex impedance spectroscopy and pulsed field gradient NMR measurements of the Ag{sup +} ion diffusivity. We found evidence suggesting that short (3.1--3.5 A) Ag-Ag distances are present. The observed prefactor for conductivity suggests that the number of mobile Ag{sup +} ions in this glass is significantly less than expected from its stoichiometry. The transport property results were examined in the light of our structural findings and analyses were attempted in terms of some reasonable microscopic models. The other major aspect of this research, dealing with amorphous poly(ethylene glycol)-LiCF{sub 3}SO{sub 3} electrolytes, involved measurements, via the pulsed field gradient NMR method, of the diffusivity of the polymer host, the cation (Li{sup +}) and the anion (CF{sub 3}SO{sub 3}{sup -}) in these complexes and the ionic conductivity, via complex impedance spectroscopy. Based on the conductivity prefactors, it appears that these amorphous polymer electrolytes exhibit classical Meyer-Nelder behavior; moreover, our ion transport results could be rationalized in terms of an ion association model (involving ion pairs and higher order aggregates).

  7. Fast-ignition transport studies: Realistic electron source, integrated particle-in-cell and hydrodynamic modeling, imposed magnetic fields

    SciTech Connect

    Strozzi, D. J.; Tabak, M.; Larson, D. J.; Divol, L.; Kemp, A. J.; Bellei, C.; Marinak, M. M.; Key, M. H.

    2012-07-15

    Transport modeling of idealized, cone-guided fast ignition targets indicates the severe challenge posed by fast-electron source divergence. The hybrid particle-in-cell (PIC) code Zuma is run in tandem with the radiation-hydrodynamics code Hydra to model fast-electron propagation, fuel heating, and thermonuclear burn. The fast electron source is based on a 3D explicit-PIC laser-plasma simulation with the PSC code. This shows a quasi two-temperature energy spectrum and a divergent angle spectrum (average velocity-space polar angle of 52 Degree-Sign ). Transport simulations with the PIC-based divergence do not ignite for >1 MJ of fast-electron energy, for a modest (70 {mu}m) standoff distance from fast-electron injection to the dense fuel. However, artificially collimating the source gives an ignition energy of 132 kJ. To mitigate the divergence, we consider imposed axial magnetic fields. Uniform fields {approx}50 MG are sufficient to recover the artificially collimated ignition energy. Experiments at the Omega laser facility have generated fields of this magnitude by imploding a capsule in seed fields of 50-100 kG. Such imploded fields will likely be more compressed in the transport region than in the laser absorption region. When fast electrons encounter increasing field strength, magnetic mirroring can reflect a substantial fraction of them and reduce coupling to the fuel. A hollow magnetic pipe, which peaks at a finite radius, is presented as one field configuration which circumvents mirroring.

  8. Experimental studies on fast-ion transport by Alfven wave avalanches on the National Spherical Torus Experiment

    SciTech Connect

    Podesta, M.; Heidbrink, W. W.; Liu, D.; Ruskov, E.; Bell, R. E.; Darrow, D. S.; Fredrickson, E. D.; Gorelenkov, N. N.; Kramer, G. J.; LeBlanc, B. P.; Medley, S. S.; Roquemore, A. L.; Crocker, N. A.; Kubota, S.; Yuh, H.

    2009-05-15

    Fast-ion transport induced by Alfven eigenmodes (AEs) is studied in beam-heated plasmas on the National Spherical Torus Experiment [Ono et al., Nucl. Fusion 40, 557 (2000)] through space, time, and energy resolved measurements of the fast-ion population. Fast-ion losses associated with multiple toroidicity-induced AEs (TAEs), which interact nonlinearly and terminate in avalanches, are characterized. A depletion of the energy range >20 keV, leading to sudden drops of up to 40% in the neutron rate over 1 ms, is observed over a broad spatial range. It is shown that avalanches lead to a relaxation of the fast-ion profile, which in turn reduces the drive for the instabilities. The measured radial eigenmode structure and frequency of TAEs are compared with the predictions from a linear magnetohydrodynamics stability code. The partial disagreement suggests that nonlinearities may compromise a direct comparison between experiment and linear theory.

  9. Fast-ion transport in q min > 2 , high- β steady-state scenarios on DIII-Da)

    NASA Astrophysics Data System (ADS)

    Holcomb, C. T.; Heidbrink, W. W.; Ferron, J. R.; Van Zeeland, M. A.; Garofalo, A. M.; Solomon, W. M.; Gong, X.; Mueller, D.; Grierson, B.; Bass, E. M.; Collins, C.; Park, J. M.; Kim, K.; Luce, T. C.; Turco, F.; Pace, D. C.; Ren, Q.; Podesta, M.

    2015-05-01

    Results from experiments on DIII-D [J. L. Luxon, Fusion Sci. Technol. 48, 828 (2005)] aimed at developing high β steady-state operating scenarios with high- q min confirm that fast-ion transport is a critical issue for advanced tokamak development using neutral beam injection current drive. In DIII-D, greater than 11 MW of neutral beam heating power is applied with the intent of maximizing β N and the noninductive current drive. However, in scenarios with q min > 2 that target the typical range of q 95 = 5-7 used in next-step steady-state reactor models, Alfvén eigenmodes cause greater fast-ion transport than classical models predict. This enhanced transport reduces the absorbed neutral beam heating power and current drive and limits the achievable βN. In contrast, similar plasmas except with q min just above 1 have approximately classical fast-ion transport. Experiments that take q min > 3 plasmas to higher β P with q 95 = 11-12 for testing long pulse operation exhibit regimes of better than expected thermal confinement. Compared to the standard high- q min scenario, the high β P cases have shorter slowing-down time and lower ∇ β fast , and this reduces the drive for Alfvénic modes, yielding nearly classical fast-ion transport, high values of normalized confinement, β N , and noninductive current fraction. These results suggest DIII-D might obtain better performance in lower- q 95 , high- q min plasmas using broader neutral beam heating profiles and increased direct electron heating power to lower the drive for Alfvén eigenmodes.

  10. Fast-ion transport in qmin>2, high- β steady-state scenarios on DIII-D

    SciTech Connect

    Holcomb, C. T.; Heidbrink, W. W.; Ferron, J. R.; Van Zeeland, M. A.; Garofalo, A. M.; Solomon, W. M.; Gong, X.; Mueller, D.; Grierson, B.; Bass, E. M.; Collins, C.; Park, J. M.; Kim, K.; Luce, T. C.; Turco, F.; Pace, D. C.; Ren, Q.; Podesta, M.

    2015-05-22

    The results from experiments on DIII-D [J. L. Luxon, Fusion Sci. Technol. 48, 828 (2005)] aimed at developing high β steady-state operating scenarios with high-qminqmin confirm that fast-ion transport is a critical issue for advanced tokamak development using neutral beam injection current drive. In DIII-D, greater than 11 MW of neutral beam heating power is applied with the intent of maximizing βN and the noninductive current drive. However, in scenarios with qmin>2 that target the typical range of q95= 5–7 used in next-step steady-state reactor models, Alfvén eigenmodes cause greater fast-ion transport than classical models predict. This enhanced transport reduces the absorbed neutral beam heating power and current drive and limits the achievable βN. Conversely similar plasmas except with qmin just above 1 have approximately classical fast-ion transport. Experiments that take qmin>3 plasmas to higher βP with q95= 11–12 for testing long pulse operation exhibit regimes of better than expected thermal confinement. Compared to the standard high-qmin scenario, the high βP cases have shorter slowing-down time and lower ∇βfast, and this reduces the drive for Alfvénic modes, yielding nearly classical fast-ion transport, high values of normalized confinement, βN, and noninductive current fraction. These results suggest DIII-D might obtain better performance in lower-q95, high-qmin plasmas using broader neutral beam heating profiles and increased direct electron heating power to lower the drive for Alfvén eigenmodes.

  11. Fast-ion transport in qmin>2, high- β steady-state scenarios on DIII-D

    DOE PAGESBeta

    Holcomb, C. T.; Heidbrink, W. W.; Ferron, J. R.; Van Zeeland, M. A.; Garofalo, A. M.; Solomon, W. M.; Gong, X.; Mueller, D.; Grierson, B.; Bass, E. M.; et al

    2015-05-22

    The results from experiments on DIII-D [J. L. Luxon, Fusion Sci. Technol. 48, 828 (2005)] aimed at developing high β steady-state operating scenarios with high-qminqmin confirm that fast-ion transport is a critical issue for advanced tokamak development using neutral beam injection current drive. In DIII-D, greater than 11 MW of neutral beam heating power is applied with the intent of maximizing βN and the noninductive current drive. However, in scenarios with qmin>2 that target the typical range of q95= 5–7 used in next-step steady-state reactor models, Alfvén eigenmodes cause greater fast-ion transport than classical models predict. This enhanced transport reducesmore » the absorbed neutral beam heating power and current drive and limits the achievable βN. Conversely similar plasmas except with qmin just above 1 have approximately classical fast-ion transport. Experiments that take qmin>3 plasmas to higher βP with q95= 11–12 for testing long pulse operation exhibit regimes of better than expected thermal confinement. Compared to the standard high-qmin scenario, the high βP cases have shorter slowing-down time and lower ∇βfast, and this reduces the drive for Alfvénic modes, yielding nearly classical fast-ion transport, high values of normalized confinement, βN, and noninductive current fraction. These results suggest DIII-D might obtain better performance in lower-q95, high-qmin plasmas using broader neutral beam heating profiles and increased direct electron heating power to lower the drive for Alfvén eigenmodes.« less

  12. Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting

    PubMed Central

    van den Bosch, Heleen M; Bünger, Meike; de Groot, Philip J; van der Meijde, Jolanda; Hooiveld, Guido JEJ; Müller, Michael

    2007-01-01

    Background Fasting has dramatic effects on small intestinal transport function. However, little is known on expression of intestinal transport and phase I/II metabolism genes during fasting and the role the fatty acid-activated transcription factor PPARα may play herein. We therefore investigated the effects of fasting on expression of these genes using Affymetrix GeneChip MOE430A arrays and quantitative RT-PCR. Results After 24 hours of fasting, expression levels of 33 of the 253 analyzed transporter and phase I/II metabolism genes were changed. Upregulated genes were involved in transport of energy-yielding molecules in processes such as glycogenolysis (G6pt1) and mitochondrial and peroxisomal oxidation of fatty acids (Cact, Mrs3/4, Fatp2, Cyp4a10, Cyp4b1). Other induced genes were responsible for the inactivation of the neurotransmitter serotonin (Sert, Sult1d1, Dtd, Papst2), formation of eicosanoids (Cyp2j6, Cyp4a10, Cyp4b1), or for secretion of cholesterol (Abca1 and Abcg8). Cyp3a11, typically known because of its drug metabolizing capacity, was also increased. Fasting had no pronounced effect on expression of phase II metabolic enzymes, except for glutathione S-transferases which were down-regulated. Time course studies revealed that some genes were acutely regulated, whereas expression of other genes was only affected after prolonged fasting. Finally, we identified 8 genes that were PPARα-dependently upregulated upon fasting. Conclusion We have characterized the response to fasting on expression of transporters and phase I/II metabolic enzymes in murine small intestine. Differentially expressed genes are involved in a variety of processes, which functionally can be summarized as a) increased oxidation of fat and xenobiotics, b) increased cholesterol secretion, c) increased susceptibility to electrophilic stressors, and d) reduced intestinal motility. This knowledge increases our understanding of gut physiology, and may be of relevance for e.g. pre

  13. Effect of Ion Cyclotron Heating on Fast Ion Transport and Plasma Rotation in Tokamaks

    NASA Astrophysics Data System (ADS)

    Chan, V. S.; Omelchenko, Y. A.; Chiu, S. C.

    2000-10-01

    Minority ion cyclotron heating can produce energetic ions with banana orbits which are finite compared with the minor radius of a tokamak. The radial transport of the fast ions in the presence of Coulomb collisions results in a radial current and a corresponding JxB torque density on the bulk plasma. Collisions with the bulk ions provides an additional frictional torque that adds to or opposes the magnetic torque. This study clarifies the various mechanisms which can contribute to the torque components including collision-induced finite orbit particle diffusion, wave-induced asymmetry in canonical momentum when doppler resonance is accounted for, and orbit asymmetry created by magnetic geometry. Ion dynamics are calculated with a Monte-Carlo code in which wave-induced energy diffusion is accounted for by a quasilinear operator. The code follows particle drift trajectories in a tokamak geometry under the influence of RF fields and collisions with the background plasma. Questions on the direction of plasma rotation under different conditions and validity of the Green's function approach in modeling RF-induced rotation will be addressed.

  14. Using the transportable, computer-operated, liquid-scintillator fast-neutron spectrometer system

    SciTech Connect

    Thorngate, J.H.

    1988-11-01

    When a detailed energy spectrum is needed for radiation-protection measurements from approximately 1 MeV up to several tens of MeV, organic-liquid scintillators make good neutron spectrometers. However, such a spectrometer requires a sophisticated electronics system and a computer to reduce the spectrum from the recorded data. Recently, we added a Nuclear Instrument Module (NIM) multichannel analyzer and a lap-top computer to the NIM electronics we have used for several years. The result is a transportable fast-neutron spectrometer system. The computer was programmed to guide the user through setting up the system, calibrating the spectrometer, measuring the spectrum, and reducing the data. Measurements can be made over three energy ranges, 0.6--2 MeV, 1.1--8 MeV, or 1.6--16 MeV, with the spectrum presented in 0.1-MeV increments. Results can be stored on a disk, presented in a table, and shown in graphical form. 5 refs., 51 figs.

  15. Hybrid Simulation of Laser-Plasma Interactions and Fast Electron Transport in Inhomogeneous Plasma

    SciTech Connect

    Cohen, B I; Kemp, A; Divol, L

    2009-05-27

    A new framework is introduced for kinetic simulation of laser-plasma interactions in an inhomogenous plasma motivated by the goal of performing integrated kinetic simulations of fast-ignition laser fusion. The algorithm addresses the propagation and absorption of an intense electromagnetic wave in an ionized plasma leading to the generation and transport of an energetic electron component. The energetic electrons propagate farther into the plasma to much higher densities where Coulomb collisions become important. The high-density plasma supports an energetic electron current, return currents, self-consistent electric fields associated with maintaining quasi-neutrality, and self-consistent magnetic fields due to the currents. Collisions of the electrons and ions are calculated accurately to track the energetic electrons and model their interactions with the background plasma. Up to a density well above critical density, where the laser electromagnetic field is evanescent, Maxwell's equations are solved with a conventional particle-based, finite-difference scheme. In the higher-density plasma, Maxwell's equations are solved using an Ohm's law neglecting the inertia of the background electrons with the option of omitting the displacement current in Ampere's law. Particle equations of motion with binary collisions are solved for all electrons and ions throughout the system using weighted particles to resolve the density gradient efficiently. The algorithm is analyzed and demonstrated in simulation examples. The simulation scheme introduced here achieves significantly improved efficiencies.

  16. Numerical modeling for energy transport and isochoric heating in ultra-fast heated high Z target

    NASA Astrophysics Data System (ADS)

    Mishra, Rohini; Sentoku, Yasuhiko; Hakel, Peter; Mancini, Roberto C.

    2010-11-01

    Collisional Particle-in-Cell (PIC) code is an effective tool to study extreme energy density conditions achieved in intense laser-solid interactions. In the continuous process of developing PIC code, we have recently implemented models to incorporate dynamic ionizations, namely Saha and Thomas Fermi, and radiation cooling (due to Bremsstrahlung and line emissions). We have also revised the existing collision model to take into account bounded electrons in dynamically ionizing target (partially ionized target). One-dimensional PIC simulation of a gold target with new collision model shows strong local heating in a micron distance due to shorter stopping range of fast electrons, which reflects the increased collision frequency due to bound electrons. The peak temperature in the heated region drops significantly due to the radiation cooling to a level of a few hundred eV from keV. We also discuss the target Z dependence on radiation loss and two-dimensional effects such as the resistive magnetic fields in the hot electron transport in metal targets.

  17. Magnetic field measurements for study of fast electron transport in magnetized HED plasma

    NASA Astrophysics Data System (ADS)

    Sawada, Hiroshi; Griffin, Brandon; Presura, Radu; Haque, Showera; Sentoku, Yasuhiko

    2014-10-01

    Interaction of megagauss magnetic fields with high energy density (HED) plasma is of great interest in the field of magnetized plasma. The field changes fundamental properties of the HED plasma such as thermal and magnetic diffusion. A coupled capability utilizing the 1.0 MA Zebra pulsed power generator and the 50 TW Leopard laser at Nevada Terawatt Facility enables to create such a condition for studies of magnetized plasma properties. We have conducted an experiment to measure magnetic fields generated by a 1.0 MA, 100 ns Zebra pulsed current in stainless steel coils. Using a 532 nm continuous laser from a single longitudinal mode laser system, the temporal change in the magnetic field was measured with the Faraday rotation in F2 glass. The probe laser passing through the 1.5 mm in radius and 1.75 mm thick glass placed in the vicinity of the inductive coils was split with a Glan-Taylor prism to measure vertical and horizontal polarization components with photodiodes. We will present the analysis of the experimental result and a design of a coupled experiment for study of fast electron transport in the magnetized plasma.

  18. Simulation of laser-plasma interactions and fast-electron transport in inhomogeneous plasma

    SciTech Connect

    Cohen, B.I. Kemp, A.J.; Divol, L.

    2010-06-20

    A new framework is introduced for kinetic simulation of laser-plasma interactions in an inhomogeneous plasma motivated by the goal of performing integrated kinetic simulations of fast-ignition laser fusion. The algorithm addresses the propagation and absorption of an intense electromagnetic wave in an ionized plasma leading to the generation and transport of an energetic electron component. The energetic electrons propagate farther into the plasma to much higher densities where Coulomb collisions become important. The high-density plasma supports an energetic electron current, return currents, self-consistent electric fields associated with maintaining quasi-neutrality, and self-consistent magnetic fields due to the currents. Collisions of the electrons and ions are calculated accurately to track the energetic electrons and model their interactions with the background plasma. Up to a density well above critical density, where the laser electromagnetic field is evanescent, Maxwell's equations are solved with a conventional particle-based, finite-difference scheme. In the higher-density plasma, Maxwell's equations are solved using an Ohm's law neglecting the inertia of the background electrons with the option of omitting the displacement current in Ampere's law. Particle equations of motion with binary collisions are solved for all electrons and ions throughout the system using weighted particles to resolve the density gradient efficiently. The algorithm is analyzed and demonstrated in simulation examples. The simulation scheme introduced here achieves significantly improved efficiencies.

  19. Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

    PubMed Central

    Morfini, Gerardo A.; Bosco, Daryl A.; Brown, Hannah; Gatto, Rodolfo; Kaminska, Agnieszka; Song, Yuyu; Molla, Linda; Baker, Lisa; Marangoni, M. Natalia; Berth, Sarah; Tavassoli, Ehsan; Bagnato, Carolina; Tiwari, Ashutosh; Hayward, Lawrence J.; Pigino, Gustavo F.; Watterson, D. Martin; Huang, Chun-Fang; Banker, Gary; Brown, Robert H.; Brady, Scott T.

    2013-01-01

    Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined. Characteristics of motor neurons affected in FALS include abnormal kinase activation, aberrant neurofilament phosphorylation, and fast axonal transport (FAT) deficits, but functional relationships among these pathogenic events were unclear. Experiments in isolated squid axoplasm reveal that FALS-related SOD1 mutant polypeptides inhibit FAT through a mechanism involving a p38 mitogen activated protein kinase pathway. Mutant SOD1 activated neuronal p38 in mouse spinal cord, neuroblastoma cells and squid axoplasm. Active p38 MAP kinase phosphorylated kinesin-1, and this phosphorylation event inhibited kinesin-1. Finally, vesicle motility assays revealed previously unrecognized, isoform-specific effects of p38 on FAT. Axon-autonomous activation of the p38 pathway represents a novel gain of toxic function for FALS-linked SOD1 proteins consistent with the dying-back pattern of neurodegeneration characteristic of ALS. PMID:23776455

  20. Fast electron generation and transport in solid matter irradiated at relativistic intensities. Evidence of vxB acceleration

    NASA Astrophysics Data System (ADS)

    Baton, S. D.; Santos, J. J.; Amiranoff, F.; Popescu, H.; Gremillet, L.; Koenig, M.; Martinolli, E.; Rousseaux, C.; Rabec-Le-Gloahec, M.; Hall, T. A.; Batani, D.; Perelli, E.; Scianitti, F.; Cowan, T. E.

    2002-11-01

    In the context of the fast electron transport in solid matter and the fast ignitor scheme,we report on measurements of second harmonic of the laser light observed on the rear side of solid targets irradiated by the 100 TW laser at LULI. This emission can be explained by the acceleration of short bunches of electrons in the front of the target by the vxB force. The observations indicate that, in our conditions, the minimum fraction of the laser energy transferred to these electron bunches is of the order of 1 °.

  1. Radial Transport Characteristics of Fast Ions Due to Energetic-Particle Modes inside the Last Closed-Flux Surface in the Compact Helical System

    SciTech Connect

    Nagaoka, Kenichi; Isobe, Mitsutaka; Toi, Kazuo; Shimizu, Akihiro; Fujisawa, Akihide; Ohshima, Shunsuke; Nakano, Haruhisa; Osakabe, Masaki; Todo, Yasushi; Akiyama, Tsuyoshi; Suzuki, Chihiro; Nishimura, Shin; Yoshimura, Yasuo; Matsuoka, Keisuke; Okamura, Shoichi; Nagashima, Yoshihiko

    2008-02-15

    The internal behavior of fast ions interacting with magnetohydrodynamic bursts excited by energetic ions has been experimentally investigated in the compact helical system. The resonant convective oscillation of fast ions was identified inside the last closed-flux surface during an energetic-particle mode (EPM) burst. The phase difference between the fast-ion oscillation and the EPM, indicating the coupling strength between them, remains a certain value during the EPM burst and drives an anomalous transport of fast ions.

  2. Fast-electron transport and heating of solid targets in high-intensity laser interactions measured by Kα fluorescence

    NASA Astrophysics Data System (ADS)

    Martinolli, E.; Koenig, M.; Baton, S. D.; Santos, J. J.; Amiranoff, F.; Batani, D.; Perelli-Cippo, E.; Scianitti, F.; Gremillet, L.; Mélizzi, R.; Decoster, A.; Rousseaux, C.; Hall, T. A.; Key, M. H.; Snavely, R.; MacKinnon, A. J.; Freeman, R. R.; King, J. A.; Stephens, R.; Neely, D.; Clarke, R. J.

    2006-04-01

    We present experimental results on fast-electron energy deposition into solid targets in ultrahigh intensity laser-matter interaction. X-ray Kα emission spectroscopy with absolute photon counting served to diagnose fast-electron propagation in multilayered targets. Target heating was measured from ionization-shifted Kα emission. Data show a 200μm fast-electron range in solid Al. The relative intensities of spectrally shifted AlKα lines imply a mean temperature of a few tens of eV up to a 100μm depth. Experimental results suggest refluxing of the electron beam at target rear side. They were compared with the predictions of both a collisional Monte Carlo and a collisional-electromagnetic, particle-fluid transport code. The validity of the code modeling of heating in such highly transient conditions is discussed.

  3. Experimental Study on Fast Electrons Transport in Ultra-intense Laser Irradiated Solid Targets by Transition Radiation

    NASA Astrophysics Data System (ADS)

    Zhijian, Zheng; Guangcan, Wang; Yuqiu, Gu

    2008-11-01

    The experiment was performed with SILEX laser facility(Ti-saphhire) at LFRC in China. The SILEX parameter: wavelength 0.8μm, duration 35fs, output power 280TW, contrast 5*105, The focal spot φ10μm(F/1.7), intensity on target surface 1*10^19W/cm^2(F/3). The main diagnostic equipments are the electron spectrometer, OMA spectrometer, optical streak camera. Some experimental results are given: The spectrum of optical emission from rear surface is rather narrow around some particular frequencies(1φ, 2φ, 3φ), We ascribe and confirm that the spike-like spectral line that is coherent transition radiation; The coherent light is also seen on time-integrated image with ring-patter due to Weibel instability of the fast electron transport; Obtained experimental cure of target thickness vs OTR image intensity is relative to mean free path of fast electron; The measuring optical transition radiation(OTR) duration of 171ps much longer than 1ps duration of fast electron transport target, the possible explanation is that the OTR duration to be determined magnetic diffusion time.

  4. Effects of age on calcium transport activity of sarcoplasmic reticulum in fast- and slow-twitch rat muscle fibres.

    PubMed Central

    Larsson, L; Salviati, G

    1989-01-01

    1. The calcium transport activity of the sarcoplasmic reticulum (SR) was measured in chemically skinned single fast- and slow-twitch muscle fibres from young (3 months) and old (23-24 months) rats. Contractile properties, the myosin heavy chain (MHC) composition and enzyme histochemical features were studied in relation to the SR characteristics. 2. In fast-twitch single motor units, the contraction time of the isometric twitch increased (P less than 0.001) from 13 +/- 1 ms in young animals to 18 +/- 2 ms in old ones. In the slow-twitch soleus, the contraction (P less than 0.001) and half-relaxation (P less than 0.05) times increased from 30 +/- 5 and 45 +/- 10 ms, respectively, in the young animals to 43 +/- 3 and 55 +/- 4 ms in the old ones. The proportion of slow-twitch (type I) fibres increased (P less than 0.05) with age in the soleus from 92 +/- 6 to 98 +/- 2% and the proportion of fast-twitch fibres (type IIA) decreased (P less than 0.01) from 6 +/- 5 to 0 +/- 0%. 3. The Ca2+ accumulation capacity (an index of SR volume), the rate of Ca2+ uptake and the fractional rate of SR filling (an estimate of the specific activity of the Ca2+ pump) were decreased by 18 (P less than 0.05), 32 (P less than 0.01) and 32% (P less than 0.001), respectively, in the old fast-twitch muscle fibres. In the slow-twitch muscle fibres, on the other hand, no significant age-related changes were observed in the Ca2+ transport activity of the SR. Thus, ageing exerts a differential influence on SR volume and function in fast- and slow-twitch fibres. 4. It is concluded that an age-related impairment of intrinsic SR function and a decrease in SR volume are probable factors underlying the decreased speed of contraction of fast-twitch muscle fibres in old age. In the slow-twitch soleus, on the other hand, one or more other mechanisms are responsible for the age-related decrease in the speed of contraction. The loss of fast-twitch muscle fibres in old soleus is one mechanism, but not the

  5. Polarized Heα Radiation by Anisotropic Fast Electron Transport in Ultra-Intense Laser Produced Plasmas

    NASA Astrophysics Data System (ADS)

    Kawamura, T.; Kai, T.; Koike, F.; Nakazaki, S.; Nishimura, H.; Inubushi, Y.; Okano, Y.; Nagatomo, H.; Batani, D.; Morace, A.; Redaelli, R.; Fourment, C.; Santos, J.; Malka, G.; Boscheron, A.; Casner, A.; Koenig, M.; Fujioka, S.; Nakamura, T.; Johzaki, T.; Mima, K.

    2009-09-01

    In fast ignition research, the transport dynamics of fast electrons is one of the critical issues. Fast electrons generated by an intense laser pulse show a highly anisotropic velocity distribution. To gain insight into the anisotropy of the velocity distribution of fast electrons, polarized x-ray spectroscopy has been proposed. The polarization spectroscopy of Cl Heα radiation was experimentally demonstrated at 1017 W/cm2 (˜100 mJ in 130 fs), and a new time-dependent atomic population kinetics code was also developed. It predicts that the high polarization arises only in a low-density region of the target plasma. Additional x-ray polarization measurements were done at 101717-18 W/cm2 (˜10 J in ˜1 ps). Polarization was measured as a function of the overcoat thickness of a target. The polarization is negative in the shallow region near the target surface, and becomes near zero at the laser intensity of ˜1018 W/cm2. At ˜1017 W/cm2, the polarization varies from negative to positive, and finally zero along with an increase in the overcoat thickness.

  6. Effects of colchicine on the intestinal transport of endogenous lipid. Ultrastructural, biochemical, and radiochemical studies in fasting rats

    SciTech Connect

    Pavelka, M.; Gangl, A.

    1983-03-01

    The involvement of microtubules in the transepithelial transport of exogenous lipid in intestinal absorptive cells has been suggested. Using electronmicroscopic, biochemical, and radiochemical methods, researchers have studied the effects of the antimicrotubular agent colchicine on the intestinal mucosa and on the intestinal transport of endogenous lipid of rats in the fasting state. After colchicine treatment, the concentration of triglycerides in intestinal mucosa of rats fasted for 24 h doubled, and electron microscopic studies showed a striking accumulation of lipid particles in absorptive epithelial cells of the tips of jejunal villi. These findings suggest that colchicine interferes with the intestinal transepithelial transport of endogenous lipoproteins. Additional studies, using an intraduodenal pulse injection of (/sup 14/C)linoleic acid, showed that colchicine does not affect the uptake of fatty acids by intestinal mucosa. However, it had divergent effects on fatty acid esterification, enhancing their incorporation into triglycerides relative to phospholipids, and caused a significant accumulation of endogenous diglycerides, triglycerides, and cholesterol esters within the absorptive intestinal epithelium. Detailed ultrastructural and morphometric studies revealed a decrease of visible microtubules, and a displacement of the smooth and rough endoplasmic reticulum and Golgi apparatus. Furthermore, it is shown that after colchicine treatment, microvilli appear at the lateral plasma membrane of intestinal absorptive cells, a change not previously reported to our knowledge. Thus, our study shows that colchicine causes significant changes in enterocyte ultrastructure and colchicine perturbs the reesterification of absorbed endogenous fatty acids and their secretion in the form of triglyceride-rich lipoproteins from the enterocyte.

  7. Parametric Dependence Of Fast-ion Transport Events On The National Spherical Torus Experiment

    SciTech Connect

    Fredrickson, Erik; Gorelenkov, N. N.; Podesta, M.; Gerhardt, S. P.; Bell, R. E.; Diallo, A.; LeBlanc, B.; Bortolon, A.

    2014-03-31

    Neutral-beam heated tokamak plasmas commonly have more than one third of the plasma kinetic energy in the non-thermal energetic beam ion population. This population of fast ions heats the plasma, provides some of the current drive, and can affect the stability (positively or negatively) of magnetohydrodynamic instabilities. This population of energetic ions is not in thermodynamic equilibrium, thus there is free-energy available to drive instabilities, which may lead to redistribution of the fast ion population. Understanding under what conditions beam-driven instabilities arise, and the extent of the resulting perturbation to the fast ion population, is important for predicting and eventually demonstrating non-inductive current ramp-up and sustainment in NSTX-U, as well as the performance of future fusion plasma experiments such as ITER. This paper presents an empirical approach towards characterizing the stability boundaries for some common energetic-ion-driven instabilities seen on NSTX.

  8. Recent experiment on fast electron transport in ultra-high intensity laser interaction

    NASA Astrophysics Data System (ADS)

    Batani, D.; Baton, S.; Koenig, M.; Guillou, P.; Loupias, B.; Vinci, T.; Rousseaux, C.; Gremillet, L.; Morace, A.; Redaelli, R.; Nakatsutsumi, M.; Kodama, R.; Ozaki, N.; Norimatsu, T.; Rassuchine, J.; Cowan, T.; Dorchies, F.; Fourment, C.; Santos, J. J.

    2008-05-01

    We performed an experiment with cone targets in planar geometry devoted to the study of fast electron generation, propagation, and target heating. This was done at LULI with the 100 TW laser at intensities up to 1019 W/cm2. Fast electrons penetration, with and without cones, was studied with different diagnostics (Kα imaging, Kα spectroscopy, visible emission) for ω or 2ω irradiation. At ω, the pre-plasma generated by the laser pedestal fills the cone and prevents the beam from reaching the tip.

  9. Comparison of measured and calculated air-transported radiation from a fast unshielded nuclear reactor. Technical report

    SciTech Connect

    Robitaille, H.A.; Hoffarth, B.E.

    1980-12-01

    Neutron and gamma-ray spectra have been measured at various distances up to 1100 metres from the fast-neutron reactor of the U.S. Army Pulse Radiation Division (Materiel Testing Directorate, Aberdeen Proving Ground, Md.) The spectra were obtained at a height of two metres above the air-ground interface and are compared to previous measurements performed by two other research laboratories, and also to the results of theoretical predictions based on two-dimensional discrete-ordinates transport theory. Integral quantities such as partial and total radiation kermas are generally in good agreement, however the theoretical calculations tend to predict somewhat softer neutron spectra than are observed experimentally.

  10. Synergy between fast-ion transport by core MHD and test blanket module fields in DIII-D experiments

    NASA Astrophysics Data System (ADS)

    Heidbrink, W. W.; Austin, M. E.; Collins, C. S.; Gray, T.; Grierson, B. A.; Kramer, G. J.; Lanctot, M.; Pace, D. C.; Van Zeeland, M. A.; Mclean, A. G.

    2015-08-01

    Fast-ion transport caused by the combination of MHD and a mock-up test-blanket module (TBM) coil is measured in the DIII-D tokamak. The primary diagnostic is an infrared camera that measures the heat flux on the tiles surrounding the coil. The combined effects of the TBM and four other potential sources of transport are studied: neoclassical tearing modes, Alfén eigenmodes, sawteeth, and applied resonant magnetic perturbation fields for the control of edge localized modes. A definitive synergistic effect is observed at sawtooth crashes where, in the presence of the TBM, the localized heat flux at a burst increases from 0.36+/- 0.27 to 2.6+/- 0.5 MW m-2.

  11. Synergy between fast-ion transport by core MHD and test blanket module fields in DIII-D experiments

    DOE PAGESBeta

    Heidbrink, W. W.; Austin, M. E.; Collins, C. S.; Gray, T.; Grierson, B. A.; Kramer, G. J.; Lanctot, M.; Pace, D. C.; Van Zeeland, M. A.; Mclean, A. G.

    2015-07-21

    We measured fast-ion transport caused by the combination of MHD and a mock-up test-blanket module (TBM) coil in the DIII-D tokamak. The primary diagnostic is an infrared camera that measures the heat flux on the tiles surrounding the coil. The combined effects of the TBM and four other potential sources of transport are studied: neoclassical tearing modes, Alfvén eigenmodes, sawteeth, and applied resonant magnetic perturbation fields for the control of edge localized modes. A definitive synergistic effect is observed at sawtooth crashes where, in the presence of the TBM, the localized heat flux at a burst increases from 0.36±0.27 tomore » 2.6±0.5 MW/m-2.« less

  12. Synergy between fast-ion transport by core MHD and test blanket module fields in DIII-D experiments

    SciTech Connect

    Heidbrink, W. W.; Austin, M. E.; Collins, C. S.; Gray, T.; Grierson, B. A.; Kramer, G. J.; Lanctot, M.; Pace, D. C.; Van Zeeland, M. A.; Mclean, A. G.

    2015-07-21

    We measured fast-ion transport caused by the combination of MHD and a mock-up test-blanket module (TBM) coil in the DIII-D tokamak. The primary diagnostic is an infrared camera that measures the heat flux on the tiles surrounding the coil. The combined effects of the TBM and four other potential sources of transport are studied: neoclassical tearing modes, Alfvén eigenmodes, sawteeth, and applied resonant magnetic perturbation fields for the control of edge localized modes. A definitive synergistic effect is observed at sawtooth crashes where, in the presence of the TBM, the localized heat flux at a burst increases from 0.36±0.27 to 2.6±0.5 MW/m-2.

  13. Boundary-artifact-free phase retrieval with the transport of intensity equation: fast solution with use of discrete cosine transform.

    PubMed

    Zuo, Chao; Chen, Qian; Asundi, Anand

    2014-04-21

    The transport of intensity equation (TIE) is a two-dimensional second order elliptic partial differential equation that must be solved under appropriate boundary conditions. However, the boundary conditions are difficult to obtain in practice. The fast Fourier transform (FFT) based TIE solutions are widely adopted for its speed and simplicity. However, it implies periodic boundary conditions, which lead to significant boundary artifacts when the imposed assumption is violated. In this work, TIE phase retrieval is considered as an inhomogeneous Neumann boundary value problem with the boundary values experimentally measurable around a hard-edged aperture, without any assumption or prior knowledge about the test object and the setup. The analytic integral solution via Green's function is given, as well as a fast numerical implementation for a rectangular region using the discrete cosine transform. This approach is applicable for the case of non-uniform intensity distribution with no extra effort to extract the boundary values from the intensity derivative signals. Its efficiency and robustness have been verified by several numerical simulations even when the objects are complex and the intensity measurements are noisy. This method promises to be an effective fast TIE solver for quantitative phase imaging applications. PMID:24787811

  14. Numerical Modeling of Coupled Variably-Saturated Fluid Flow and Reactive Transport with Fast and Slow Chemical Reactions

    SciTech Connect

    LI, MING-HSU; SIEGEL, MALCOLM D.; YEH, GOUR-TSYH

    1999-09-20

    The couplings among chemical reaction rates, advective and diffusive transport in fractured media or soils, and changes in hydraulic properties due to precipitation and dissolution within fractures and in rock matrix are important for both nuclear waste disposal and remediation of contaminated sites. This paper describes the development and application of LEHGC2.0, a mechanistically-based numerical model for simulation of coupled fluid flow and reactive chemical transport including both fast and slow reactions invariably saturated media. Theoretical bases and numerical implementations are summarized, and two example problems are demonstrated. The first example deals with the effect of precipitation-dissolution on fluid flow and matrix diffusion in a two-dimensional fractured media. Because of the precipitation and decreased diffusion of solute from the fracture into the matrix, retardation in the fractured medium is not as large as the case wherein interactions between chemical reactions and transport are not considered. The second example focuses on a complicated but realistic advective-dispersive-reactive transport problem. This example exemplifies the need for innovative numerical algorithms to solve problems involving stiff geochemical reactions.

  15. Life cycle assessment of the production of hydrogen and transportation fuels from corn stover via fast pyrolysis

    NASA Astrophysics Data System (ADS)

    Zhang, Yanan; Hu, Guiping; Brown, Robert C.

    2013-06-01

    This life cycle assessment evaluates and quantifies the environmental impacts of the production of hydrogen and transportation fuels from the fast pyrolysis and upgrading of corn stover. Input data for this analysis come from Aspen Plus modeling, a GREET (Greenhouse Gases, Regulated Emissions, and Energy Use in Transportation) model database and a US Life Cycle Inventory Database. SimaPro 7.3 software is employed to estimate the environmental impacts. The results indicate that the net fossil energy input is 0.25 MJ and 0.23 MJ per km traveled for a light-duty vehicle fueled by gasoline and diesel fuel, respectively. Bio-oil production requires the largest fossil energy input. The net global warming potential (GWP) is 0.037 kg CO2eq and 0.015 kg CO2eq per km traveled for a vehicle fueled by gasoline and diesel fuel, respectively. Vehicle operations contribute up to 33% of the total positive GWP, which is the largest greenhouse gas footprint of all the unit processes. The net GWPs in this study are 88% and 94% lower than for petroleum-based gasoline and diesel fuel (2005 baseline), respectively. Biomass transportation has the largest impact on ozone depletion among all of the unit processes. Sensitivity analysis shows that fuel economy, transportation fuel yield, bio-oil yield, and electricity consumption are the key factors that influence greenhouse gas emissions.

  16. Guidelines for Transportation, Handling, and Use of Fast Pyrolysis Bio-Oil. Part 1. Flammability and Toxicity

    SciTech Connect

    Oasmaa, Anja; Kalli, Anssi; Lindfors, Christian; Elliott, Douglas C.; Springer, David L.; Peacocke, Cordner; Chiaramonti, David

    2012-05-04

    An alternative sustainable fuel, biomass-derived fast pyrolysis oil or 'bio-oil', is coming into the market. Fast pyrolysis pilot and demonstration plants for fuel applications producing tonnes of bio-oil are in operation, and commercial plants are under design. There will be increasingly larger amounts of bio-oil transportation on water and by land, leading to a need for specifications and supporting documentation. Bio-oil is different from conventional liquid fuels, and therefore must overcome both technical and marketing hurdles for its acceptability in the fuels market. A comprehensive Material Safety Data Sheet (MSDS) is required, backed with independent testing and certification. In order to standardise bio-oil quality specifications are needed. The first bio-oil burner fuel standard in ASTM (D7544) was approved in 2009. CEN standardisation has been initiated in Europe. In the EU a new chemical regulation system, REACH (Registration, Evaluation and Authorisation of Chemicals) is being applied. Registration under REACH has to be made if bio-oil is produced or imported to the EU. In the USA and Canada, bio-oil has to be filed under TOSCA (US Toxic Substances Control Act). In this paper the state of the art on standardisation is discussed, and new data for the transportation guidelines is presented. The focus is on flammability and toxicity.

  17. A CFD-based wind solver for a fast response transport and dispersion model

    SciTech Connect

    Gowardhan, Akshay A; Brown, Michael J; Pardyjak, Eric R; Senocak, Inanc

    2010-01-01

    In many cities, ambient air quality is deteriorating leading to concerns about the health of city inhabitants. In urban areas with narrow streets surrounded by clusters of tall buildings, called street canyons, air pollution from traffic emissions and other sources is difficult to disperse and may accumulate resulting in high pollutant concentrations. For various situations, including the evacuation of populated areas in the event of an accidental or deliberate release of chemical, biological and radiological agents, it is important that models should be developed that produce urban flow fields quickly. For these reasons it has become important to predict the flow field in urban street canyons. Various computational techniques have been used to calculate these flow fields, but these techniques are often computationally intensive. Most fast response models currently in use are at a disadvantage in these cases as they are unable to correlate highly heterogeneous urban structures with the diagnostic parameterizations on which they are based. In this paper, a fast and reasonably accurate computational fluid dynamics (CFD) technique that solves the Navier-Stokes equations for complex urban areas has been developed called QUIC-CFD (Q-CFD). This technique represents an intermediate balance between fast (on the order of minutes for a several block problem) and reasonably accurate solutions. The paper details the solution procedure and validates this model for various simple and complex urban geometries.

  18. Integrated Simulations of Hot-Electron Transport and Ignition for Direct-Drive, Fast-Ignition Targets

    NASA Astrophysics Data System (ADS)

    Solodov, A.

    2008-11-01

    A thorough understanding of future integrated fast-ignition experiments combining compression and heating for high-density thermonuclear fuel require hybrid (fluid+particle) simulations of the implosion and ignition process. Very different spatial and temporal scales need to be resolved to model the entire fast-ignition experiment. The 2-D axisymmetric hydrocode DRACO and the 2-D/3-D hybrid-PIC code LSP have been integrated to simulate the implosion and heating of direct-drive fast-ignition fusion targets. DRACO includes the physics required to simulate compression, ignition, and burn of fast-ignition targets. LSP simulates the transport of hot electrons from the place where they are generated by a petawatt laser pulse to the dense fuel core where their energy is absorbed. The results of integrated simulations of optimized spherically symmetric and cone-in-shell DT, high-gain, fast-ignition targets will be presented. The minimum energy required for ignition is found for hot electrons with a realistic angular spread and Maxwellian energy-distribution function. The results from simulations of cone-in-shell plastic targets designed for fast-ignition experiments on OMEGA EP will be presented. Target heating and neutron yield are computed. Resistive Weibel instability is found to break the hot-electron beam into filaments. The global self-generated resistive magnetic field of the beam is found to collimate the hot electrons. The self-generated field increases the coupling efficiency of hot electrons with the target core and reduces the minimum energy required for ignition. This work was supported by the U.S. Department of Energy under Cooperative Agreement Nos. DE-FC02-04ER54789 and DE-FC52-08NA28302. Contributors: K.S. Anderson, R. Betti, V. Gotcheva, J.F. Myatt, J.A. Delettrez, S. Skupsky. P. B. Radha et al., Phys. Plasmas 12, 056307 (2005). D. R. Welch et al., Phys. Plasmas 13, 063105 (2006). R. Betti and C. Zhou, Phys. Plasmas 12, 110702 (2005). B. Chrisman, Y

  19. Microwave-assisted fast vapor-phase transport synthesis of MnAPO-5 molecular sieves

    SciTech Connect

    Shao Hui; Yao Jianfeng; Ke Xuebin; Zhang Lixiong Xu Nanping

    2009-04-02

    MnAPO-5 was prepared by a microwave-assisted vapor-phase transport method at 180 deg. C in short times. The products were characterized by X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectra, UV-vis spectroscopic measurement, NH{sub 3}-temperature-programmed desorption and esterification reaction. It was found that dry gels prepared with aluminum isopropoxide, phosphoric acid and manganese acetate could be transferred to MnAPO-5 in the vapors of triethylamine and water by the microwave-assisted vapor-phase transport method at 180 deg. C for less than 30 min. The crystallization time was greatly reduced by the microwave heating compared with the conventional heating. The resulting MnAPO-5 exhibited much smaller particle sizes, higher surface areas and slightly higher catalytic activity in the esterification of acetic acid and butyl alcohol than those prepared by the conventional vapor-phase transport method and hydrothermal synthesis.

  20. Pharmacokinetic Model of the Transport of Fast-Acting Insulin From the Subcutaneous and Intradermal Spaces to Blood

    PubMed Central

    Lv, Dayu; Kulkarni, Sandip D.; Chan, Alice; Keith, Stephen; Pettis, Ron; Kovatchev, Boris P.; Farhi, Leon S.; Breton, Marc D.

    2015-01-01

    Pharmacokinetic (PK) models describing the transport of insulin from the injection site to blood assist clinical decision making and are part of in silico platforms for developing and testing of insulin delivery strategies for treatment of patients with diabetes. The ability of these models to accurately describe all facets of the in vivo insulin transport is therefore critical for their application. Here, we propose a new model of fast-acting insulin analogs transport from the subcutaneous and intradermal spaces to blood that can accommodate clinically observed biphasic appearance and delayed clearance of injected insulin, 2 phenomena that are not captured by existing PK models. To develop the model we compare 9 insulin transport PK models which describe hypothetical insulin delivery pathways potentially capable of approximating biphasic appearance of exogenous insulin. The models are tested with respect to their ability to describe clinical data from 10 healthy volunteers which received 1 subcutaneous and 2 intradermal insulin injections on 3 different occasions. The optimal model, selected based on information and posterior identifiability criteria, assumes that insulin is delivered at the administrative site and is then transported to the bloodstream via 2 independent routes (1) diffusion-like process to the blood and (2) combination of diffusion-like processes followed by an additional compartment before entering the blood. This optimal model accounts for biphasic appearance and delayed clearance of exogenous insulin. It agrees better with the clinical data as compared to commonly used models and is expected to improve the in silico development and testing of insulin treatment strategies, including artificial pancreas systems. PMID:25759184

  1. Pharmacokinetic Model of the Transport of Fast-Acting Insulin From the Subcutaneous and Intradermal Spaces to Blood.

    PubMed

    Lv, Dayu; Kulkarni, Sandip D; Chan, Alice; Keith, Stephen; Pettis, Ron; Kovatchev, Boris P; Farhi, Leon S; Breton, Marc D

    2015-07-01

    Pharmacokinetic (PK) models describing the transport of insulin from the injection site to blood assist clinical decision making and are part of in silico platforms for developing and testing of insulin delivery strategies for treatment of patients with diabetes. The ability of these models to accurately describe all facets of the in vivo insulin transport is therefore critical for their application. Here, we propose a new model of fast-acting insulin analogs transport from the subcutaneous and intradermal spaces to blood that can accommodate clinically observed biphasic appearance and delayed clearance of injected insulin, 2 phenomena that are not captured by existing PK models. To develop the model we compare 9 insulin transport PK models which describe hypothetical insulin delivery pathways potentially capable of approximating biphasic appearance of exogenous insulin. The models are tested with respect to their ability to describe clinical data from 10 healthy volunteers which received 1 subcutaneous and 2 intradermal insulin injections on 3 different occasions. The optimal model, selected based on information and posterior identifiability criteria, assumes that insulin is delivered at the administrative site and is then transported to the bloodstream via 2 independent routes (1) diffusion-like process to the blood and (2) combination of diffusion-like processes followed by an additional compartment before entering the blood. This optimal model accounts for biphasic appearance and delayed clearance of exogenous insulin. It agrees better with the clinical data as compared to commonly used models and is expected to improve the in silico development and testing of insulin treatment strategies, including artificial pancreas systems. PMID:25759184

  2. Bioinspired tilt-angle fabricated structure gradient fibers: micro-drops fast transport in a long-distance.

    PubMed

    Chen, Yuan; Wang, Lin; Xue, Yan; Jiang, Lei; Zheng, Yongmei

    2013-01-01

    Issues of surfaces, e.g., inspired from beetle's back, spider silk, cactus stem, etc., become the active area of research on designing novel materials in need of human beings to acquire fresh water resource from air. However, the design of materials on surface structure is little achieved on controlling of micro-scale drop transport in a long distance. Here, we report the ability of micro-drop transport in a long distance on a bioinspired Fibers with Gradient Spindle-knots (BFGS), which are fabricated by tilt angle dip-coating method. The micro-drop of ~0.25 μL transports in distance of ~5.00 mm, with velocity of 0.10-0.22 m s⁻¹ on BFGS. It is attributed to the multi-level cooperation of the release energy of drop coalescence along the gradient spindle-knots, in addition to capillary adhesion force and continuous difference of Laplace pressure, accordingly, water drops are driven to move fast directionally in a long distance on BFGS. PMID:24113433

  3. Bioinspired tilt-angle fabricated structure gradient fibers: micro-drops fast transport in a long-distance

    NASA Astrophysics Data System (ADS)

    Chen, Yuan; Wang, Lin; Xue, Yan; Jiang, Lei; Zheng, Yongmei

    2013-10-01

    Issues of surfaces, e.g., inspired from beetle's back, spider silk, cactus stem, etc., become the active area of research on designing novel materials in need of human beings to acquire fresh water resource from air. However, the design of materials on surface structure is little achieved on controlling of micro-scale drop transport in a long distance. Here, we report the ability of micro-drop transport in a long distance on a bioinspired Fibers with Gradient Spindle-knots (BFGS), which are fabricated by tilt angle dip-coating method. The micro-drop of ~0.25 μL transports in distance of ~5.00 mm, with velocity of 0.10-0.22 m s-1 on BFGS. It is attributed to the multi-level cooperation of the release energy of drop coalescence along the gradient spindle-knots, in addition to capillary adhesion force and continuous difference of Laplace pressure, accordingly, water drops are driven to move fast directionally in a long distance on BFGS.

  4. Development of a New and Fast Linear Solver for Multi-component Reactive Transport Simulation

    NASA Astrophysics Data System (ADS)

    Qiao, C.; Li, L.; Bao, C.; Hu, X.; Johns, R.; Xu, J.

    2013-12-01

    Reactive transport models (RTM) have been extensively used to understand the coupling between solute transport and (bio) geochemical reactions in complex earth systems. RTM typically involves a large number of primary and secondary species with a complex reaction network in large domains. The computational expenses increase significantly with the number of grid blocks and the number of chemical species. Within both the operator splitting approach (OS) and the global implicit approach (GI) that are commonly used, the steps that involve Newton-Raphson method are typically one of the most time-consuming parts (up to 80% to 90% of CPU times). Under such circumstances, accelerating reactive transport simulation is very essential. In this research, we present a physics-based linear system solution strategy for general reactive transport models with many species. We observed up to five times speed up for the linear solver portion of the simulations in our test cases. Our new linear solver takes advantage of the sparsity of the Jacobian matrix arising from the reaction network. The Jacobian matrix for the speciation problem is typically considered as a dense matrix and solved with a direct method such as Gaussian elimination. For the reactive transport problem, the graph of the local Jacobian matrix has a one-to-one correspondence to the reaction network graph. The Jacobian matrix is commonly sparse and has the same sparsity structure for the same reaction network. We developed a strategy that performs a minimum degree of reordering and symbolic factorization to determine the non-zero pattern at the beginning of the OS and GI simulation. During the speciation calculation in OS, we calculate the L and U factors and solve the triangular matrices according to the non-zero pattern. For GI, our strategy can be applied to inverse the diagonal blocks in the block-Jacobi preconditioner and smoothers of the multigrid preconditioners in iterative solvers. Our strategy is naturally

  5. Fast Na/+/-ion transport in skeleton structures. [solid electrolyte applications

    NASA Technical Reports Server (NTRS)

    Goodenough, J. B.; Hong, H. Y.-P.; Kafalas, J. A.

    1976-01-01

    The skeleton structures considered in the investigations consist of a rigid subarray with an interconnected interstitial space in which ions move in three dimensions. The classes of skeleton structures investigated include the Im3 phase of high-pressure KSbO3, the defect-pyrochlore structure illustrated by RbMgAlF6, and the carnegieite structure of high-temperature NaAlSiO4. A description is given of the results obtained in transport measurements involving dense polycrystalline ceramic disks. Results obtained in the case of the Na(+)-ion transport in Na3Zr2PSi2O12 appear particularly promising concerning the possible use of such substances in solid-electrolyte applications.

  6. Fast Tree Multigrid Transport Application for the Simplified P{sub 3} Approximation

    SciTech Connect

    Kotiluoto, Petri

    2001-07-15

    Calculation of neutron flux in three-dimensions is a complex problem. A novel approach for solving complicated neutron transport problems is presented, based on the tree multigrid technique and the Simplified P{sub 3} (SP{sub 3}) approximation. Discretization of the second-order elliptic SP{sub 3} equations is performed for a regular three-dimensional octree grid by using an integrated scheme. The octree grid is generated directly from STL files, which can be exported from practically all computer-aided design-systems. Marshak-like boundary conditions are utilized. Iterative algorithms are constructed for SP{sub 3} approximation with simple coarse-to-fine prolongation and fine-to-coarse restriction operations of the tree multigrid technique. Numerical results are presented for a simple cylindrical homogeneous one-group test case and for a simplistic two-group pressurized water reactor pressure vessel fluence calculation benchmark. In the former homogeneous test case, a very good agreement with 1.6% maximal deviation compared with DORT results was obtained. In the latter test case, however, notable discrepancies were observed. These comparisons show that the tree multigrid technique is capable of solving three-dimensional neutron transport problems with a very low computational cost, but that the SP{sub 3} approximation itself is not satisfactory for all problems. However, the tree multigrid technique is a very promising new method for neutron transport.

  7. Direct observation of ultrafast surface transport of laser-driven fast electrons in a solid target

    SciTech Connect

    Singh, Prashant Kumar; Chatterjee, Gourab; Adak, Amitava; Ahmed, Saima; Lad, Amit D.; Ravindra Kumar, G.; Cui, Y. Q.; Wang, W. M.; Sheng, Z. M.

    2013-11-15

    We demonstrate rapid spread of surface ionization on a glass target excited by an intense, ultrashort laser pulse at an intensity of 3 × 10{sup 17} W cm{sup −2}. Time- and space-resolved reflectivity of the target surface indicates that the initial plasma region created by the pump pulse expands at c/7. The measured quasi-static megagauss magnetic field is found to expand in a manner very similar to that of surface ionization. Two-dimensional particle-in-cell simulations reproduce measurements of surface ionization and magnetic fields. Both the experiment and simulation convincingly demonstrate the role of self-induced electric and magnetic fields in confining fast electrons along the target-vacuum interface.

  8. Direct observation of ultrafast surface transport of laser-driven fast electrons in a solid target

    NASA Astrophysics Data System (ADS)

    Singh, Prashant Kumar; Cui, Y. Q.; Chatterjee, Gourab; Adak, Amitava; Wang, W. M.; Ahmed, Saima; Lad, Amit D.; Sheng, Z. M.; Ravindra Kumar, G.

    2013-11-01

    We demonstrate rapid spread of surface ionization on a glass target excited by an intense, ultrashort laser pulse at an intensity of 3 × 1017 W cm-2. Time- and space-resolved reflectivity of the target surface indicates that the initial plasma region created by the pump pulse expands at c/7. The measured quasi-static megagauss magnetic field is found to expand in a manner very similar to that of surface ionization. Two-dimensional particle-in-cell simulations reproduce measurements of surface ionization and magnetic fields. Both the experiment and simulation convincingly demonstrate the role of self-induced electric and magnetic fields in confining fast electrons along the target-vacuum interface.

  9. Temporally resolved characterization of shock-heated foam target with Al absorption spectroscopy for fast electron transport study

    SciTech Connect

    Yabuuchi, T.; Sawada, H.; Wei, M. S.; Beg, F. N.; Regan, S. P.; Anderson, K.; Betti, R.; Hund, J.; Paguio, R. R.; Saito, K. M.; Stephens, R. B.; Key, M. H.; Mackinnon, A. J.; McLean, H. S.; Patel, P. K.; Wilks, S. C.

    2012-09-15

    The CH foam plasma produced by a laser-driven shock wave has been characterized by a temporally resolved Al 1s-2p absorption spectroscopy technique. A 200 mg/cm{sup 3} foam target with Al dopant was developed for this experiment, which used an OMEGA EP [D. D. Meyerhofer et al., J. Phys.: Conf. Ser. 244, 032010 (2010)] long pulse beam with an energy of 1.2 kJ and 3.5 ns pulselength. The plasma temperatures were inferred with the accuracy of 5 eV from the fits to the measurements using an atomic physics code. The results show that the inferred temperature is sustained at 40-45 eV between 6 and 7 ns and decreases to 25 eV at 8 ns. 2-D radiation hydrodynamic simulations show a good agreement with the measurements. Application of the shock-heated foam plasma platform toward fast electron transport experiments is discussed.

  10. Laser-driven cylindrical compression of targets for fast electron transport study in warm and dense plasmas

    SciTech Connect

    Vauzour, B.; Nicolaie, Ph.; Dorchies, F.; Fourment, C.; Hulin, S.; Regan, C.; Ribeyre, X.; Schurtz, G.; Santos, J. J.; Perez, F.; Baton, S. D.; Brambrink, E.; Volpe, L.; Batani, D.; Jafer, R.; Lancaster, K.; Galimberti, M.; Heathcote, R.; Beg, F. N.; Chawla, S.

    2011-04-15

    Fast ignition requires a precise knowledge of fast electron propagation in a dense hydrogen plasma. In this context, a dedicated HiPER (High Power laser Energy Research) experiment was performed on the VULCAN laser facility where the propagation of relativistic electron beams through cylindrically compressed plastic targets was studied. In this paper, we characterize the plasma parameters such as temperature and density during the compression of cylindrical polyimide shells filled with CH foams at three different initial densities. X-ray and proton radiography were used to measure the cylinder radius at different stages of the compression. By comparing both diagnostics results with 2D hydrodynamic simulations, we could infer densities from 2 to 11 g/cm{sup 3} and temperatures from 30 to 120 eV at maximum compression at the center of targets. According to the initial foam density, kinetic, coupled (sometimes degenerated) plasmas were obtained. The temporal and spatial evolution of the resulting areal densities and electrical conductivities allow for testing electron transport in a wide range of configurations.

  11. Quantitative measurements and modeling of cargo–motor interactions during fast transport in the living axon

    PubMed Central

    Seamster, Pamela E; Loewenberg, Michael; Pascal, Jennifer; Chauviere, Arnaud; Gonzales, Aaron; Cristini, Vittorio; Bearer, Elaine L

    2013-01-01

    The kinesins have long been known to drive microtubule-based transport of sub-cellular components, yet the mechanisms of their attachment to cargo remain a mystery. Several different cargo-receptors have been proposed based on their in vitro binding affinities to kinesin-1. Only two of these—phosphatidyl inositol, a negatively charged lipid, and the carboxyl terminus of the amyloid precursor protein (APP-C), a trans-membrane protein—have been reported to mediate motility in living systems. A major question is how these many different cargo, receptors and motors interact to produce the complex choreography of vesicular transport within living cells. Here we describe an experimental assay that identifies cargo–motor receptors by their ability to recruit active motors and drive transport of exogenous cargo towards the synapse in living axons. Cargo is engineered by derivatizing the surface of polystyrene fluorescent nanospheres (100 nm diameter) with charged residues or with synthetic peptides derived from candidate motor receptor proteins, all designed to display a terminal COOH group. After injection into the squid giant axon, particle movements are imaged by laser-scanning confocal time-lapse microscopy. In this report we compare the motility of negatively charged beads with APP-C beads in the presence of glycine-conjugated non-motile beads using new strategies to measure bead movements. The ensuing quantitative analysis of time-lapse digital sequences reveals detailed information about bead movements: instantaneous and maximum velocities, run lengths, pause frequencies and pause durations. These measurements provide parameters for a mathematical model that predicts the spatiotemporal evolution of distribution of the two different types of bead cargo in the axon. The results reveal that negatively charged beads differ from APP-C beads in velocity and dispersion, and predict that at long time points APP-C will achieve greater progress towards the presynaptic

  12. Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon

    NASA Astrophysics Data System (ADS)

    Seamster, Pamela E.; Loewenberg, Michael; Pascal, Jennifer; Chauviere, Arnaud; Gonzales, Aaron; Cristini, Vittorio; Bearer, Elaine L.

    2012-10-01

    The kinesins have long been known to drive microtubule-based transport of sub-cellular components, yet the mechanisms of their attachment to cargo remain a mystery. Several different cargo-receptors have been proposed based on their in vitro binding affinities to kinesin-1. Only two of these—phosphatidyl inositol, a negatively charged lipid, and the carboxyl terminus of the amyloid precursor protein (APP-C), a trans-membrane protein—have been reported to mediate motility in living systems. A major question is how these many different cargo, receptors and motors interact to produce the complex choreography of vesicular transport within living cells. Here we describe an experimental assay that identifies cargo-motor receptors by their ability to recruit active motors and drive transport of exogenous cargo towards the synapse in living axons. Cargo is engineered by derivatizing the surface of polystyrene fluorescent nanospheres (100 nm diameter) with charged residues or with synthetic peptides derived from candidate motor receptor proteins, all designed to display a terminal COOH group. After injection into the squid giant axon, particle movements are imaged by laser-scanning confocal time-lapse microscopy. In this report we compare the motility of negatively charged beads with APP-C beads in the presence of glycine-conjugated non-motile beads using new strategies to measure bead movements. The ensuing quantitative analysis of time-lapse digital sequences reveals detailed information about bead movements: instantaneous and maximum velocities, run lengths, pause frequencies and pause durations. These measurements provide parameters for a mathematical model that predicts the spatiotemporal evolution of distribution of the two different types of bead cargo in the axon. The results reveal that negatively charged beads differ from APP-C beads in velocity and dispersion, and predict that at long time points APP-C will achieve greater progress towards the presynaptic

  13. Antibodies Covalently Immobilized on Actin Filaments for Fast Myosin Driven Analyte Transport

    PubMed Central

    Kumar, Saroj; ten Siethoff, Lasse; Persson, Malin; Lard, Mercy; te Kronnie, Geertruy; Linke, Heiner; Månsson, Alf

    2012-01-01

    Biosensors would benefit from further miniaturization, increased detection rate and independence from external pumps and other bulky equipment. Whereas transportation systems built around molecular motors and cytoskeletal filaments hold significant promise in the latter regard, recent proof-of-principle devices based on the microtubule-kinesin motor system have not matched the speed of existing methods. An attractive solution to overcome this limitation would be the use of myosin driven propulsion of actin filaments which offers motility one order of magnitude faster than the kinesin-microtubule system. Here, we realized a necessary requirement for the use of the actomyosin system in biosensing devices, namely covalent attachment of antibodies to actin filaments using heterobifunctional cross-linkers. We also demonstrated consistent and rapid myosin II driven transport where velocity and the fraction of motile actin filaments was negligibly affected by the presence of antibody-antigen complexes at rather high density (>20 µm−1). The results, however, also demonstrated that it was challenging to consistently achieve high density of functional antibodies along the actin filament, and optimization of the covalent coupling procedure to increase labeling density should be a major focus for future work. Despite the remaining challenges, the reported advances are important steps towards considerably faster nanoseparation than shown for previous molecular motor based devices, and enhanced miniaturization because of high bending flexibility of actin filaments. PMID:23056279

  14. Antibodies covalently immobilized on actin filaments for fast myosin driven analyte transport.

    PubMed

    Kumar, Saroj; ten Siethoff, Lasse; Persson, Malin; Lard, Mercy; te Kronnie, Geertruy; Linke, Heiner; Månsson, Alf

    2012-01-01

    Biosensors would benefit from further miniaturization, increased detection rate and independence from external pumps and other bulky equipment. Whereas transportation systems built around molecular motors and cytoskeletal filaments hold significant promise in the latter regard, recent proof-of-principle devices based on the microtubule-kinesin motor system have not matched the speed of existing methods. An attractive solution to overcome this limitation would be the use of myosin driven propulsion of actin filaments which offers motility one order of magnitude faster than the kinesin-microtubule system. Here, we realized a necessary requirement for the use of the actomyosin system in biosensing devices, namely covalent attachment of antibodies to actin filaments using heterobifunctional cross-linkers. We also demonstrated consistent and rapid myosin II driven transport where velocity and the fraction of motile actin filaments was negligibly affected by the presence of antibody-antigen complexes at rather high density (>20 µm(-1)). The results, however, also demonstrated that it was challenging to consistently achieve high density of functional antibodies along the actin filament, and optimization of the covalent coupling procedure to increase labeling density should be a major focus for future work. Despite the remaining challenges, the reported advances are important steps towards considerably faster nanoseparation than shown for previous molecular motor based devices, and enhanced miniaturization because of high bending flexibility of actin filaments. PMID:23056279

  15. Fast Solutions of Maxwell's Equation for High Resolution Electromagnetic Imaging of Transport Pathways

    SciTech Connect

    DAY,DAVID M.; NEWMAN,GREGORY A.

    1999-10-01

    A fast precondition technique has been developed which accelerates the finite difference solutions of the 3D Maxwell's equations for geophysical modeling. The technique splits the electric field into its curl free and divergence free projections, and allows for the construction of an inverse operator. Test examples show an order of magnitude speed up compared with a simple Jacobi preconditioner. Using this preconditioner a low frequency Neumann series expansion is developed and used to compute responses at multiple frequencies very efficiently. Simulations requiring responses at multiple frequencies, show that the Neumann series is faster than the preconditioned solution, which must compute solutions at each discrete frequency. A Neumann series expansion has also been developed in the high frequency limit along with spectral Lanczos methods in both the high and low frequency cases for simulating multiple frequency responses with maximum efficiency. The research described in this report was to have been carried out over a two-year period. Because of communication difficulties, the project was funded for first year only. Thus the contents of this report are incomplete with respect to the original project objectives.

  16. Techno-Economic Analysis of Biomass Fast Pyrolysis to Transportation Fuels

    SciTech Connect

    Wright, M. M.; Satrio, J. A.; Brown, R. C.; Daugaard, D. E.; Hsu, D. D.

    2010-11-01

    This study develops techno-economic models for assessment of the conversion of biomass to valuable fuel products via fast pyrolysis and bio-oil upgrading. The upgrading process produces a mixture of naphtha-range (gasoline blend stock) and diesel-range (diesel blend stock) products. This study analyzes the economics of two scenarios: onsite hydrogen production by reforming bio-oil, and hydrogen purchase from an outside source. The study results for an nth plant indicate that petroleum fractions in the naphtha distillation range and in the diesel distillation range are produced from corn stover at a product value of $3.09/gal ($0.82/liter) with onsite hydrogen production or $2.11/gal ($0.56/liter) with hydrogen purchase. These values correspond to a $0.83/gal ($0.21/liter) cost to produce the bio-oil. Based on these nth plant numbers, product value for a pioneer hydrogen-producing plant is about $6.55/gal ($1.73/liter) and for a pioneer hydrogen-purchasing plant is about $3.41/gal ($0.92/liter). Sensitivity analysis identifies fuel yield as a key variable for the hydrogen-production scenario. Biomass cost is important for both scenarios. Changing feedstock cost from $50-$100 per short ton changes the price of fuel in the hydrogen production scenario from $2.57-$3.62/gal ($0.68-$0.96/liter).

  17. Transport coefficient free scaling laws for convection and magnetism in fast rotating planets

    NASA Astrophysics Data System (ADS)

    Starchenko, S. V.

    2013-09-01

    In the limit of negligible molecular diffusivity, viscosity and magnetic diffusivity effects, Scaling laws for convection and magnetism are derived for fast rotating planets. In the Earth, Jupiter, Saturn and ancient dynamo active Mars it is reasonable to suppose domination of magnetic energy over kinetic one that results in the typical magnetic field B proportional to the third root of the buoyancy flux F [3] driving the convection, while B is independent on conductivity σ and angular rotation rate Ω. The same scaling law was previously obtained via compilation of many numerical planetary dynamo simulations [1-3]. Besides, new scaling laws are obtained for typical hydrodynamic scale h, velocity V, Archimedean acceleration A, electromagnetic scale d and sinus of the angle between magnetic and velocity vector s. In Uranus, Neptune and Ganymede a local magnetic Reynolds number rm=μσVd~1 with magnetic permeability in vacuum μ. Correspondent magnetic energy could be of order kinetic energy resulting in relatively lower magnetic field strength B=(μρ)1/2V with density ρ. That may explain magnetic field values and non-dipolar structures in Uranus, Neptune and Ganymede.

  18. The transport characteristics of passing fast ions produced by nonlocal overlapping of drift island surfaces and magnetic island surfaces

    NASA Astrophysics Data System (ADS)

    Cao, Jinjia; Gong, Xueyu; Xiang, Dong; Huang, Qianhong; Yu, Jun

    2016-08-01

    The structure of the drift-island surface of passing fast ions (PFIs) is investigated in the presence of the resonant interaction with a magnetic island. Two overlapping regions of the drift-island surface and the magnetic island surface are found, one corresponding to local overlapping region and the other to non-local one. Here, the word "nonlocal" denotes that the resonances in the core plasma can have effects on the PFIs near the plasma boundary, while the "local" represents that the PFIs just near the resonant location are influenced. The nonlocal overlapping constructs a transport path along which the PFIs can become losses. There are three kinds of drift-island surfaces to join in forming the transport paths. A pitch angle region, which is called pitch angle gap, is found near the plasma boundary, where the drift-island surface cannot be formed and few PFIs are lost. The pitch-angle selective features of PFI losses are obtained by analyzing the three kinds of drift-island surfaces. The coupling between the crowd drift island surfaces and the collision can induce the prompt losses of PFIs and rapidly slowing down of PFI energy. The time of the prompt losses and the slowing down rate are calculated. Qualitatively, the theoretical results are in well agreement with the experimental observations in ASDEX Upgrade [M. García-Muñoz et al., Nucl. Fusion 47, L10 (2007)].

  19. Polymers with Cavities Tuned for Fast Selective Transport of Small Molecules and Ions

    NASA Astrophysics Data System (ADS)

    Park, Ho Bum; Jung, Chul Ho; Lee, Young Moo; Hill, Anita J.; Pas, Steven J.; Mudie, Stephen T.; Van Wagner, Elizabeth; Freeman, Benny D.; Cookson, David J.

    2007-10-01

    Within a polymer film, free-volume elements such as pores and channels typically have a wide range of sizes and topologies. This broad range of free-volume element sizes compromises a polymer’s ability to perform molecular separations. We demonstrated free-volume structures in dense vitreous polymers that enable outstanding molecular and ionic transport and separation performance that surpasses the limits of conventional polymers. The unusual microstructure in these materials can be systematically tailored by thermally driven segment rearrangement. Free-volume topologies can be tailored by controlling the degree of rearrangement, flexibility of the original chain, and judicious inclusion of small templating molecules. This rational tailoring of free-volume element architecture provides a route for preparing high-performance polymers for molecular-scale separations.

  20. Radiological transportation risk assessment of the shipment of sodium-bonded fuel from the Fast Flux Test Facility to the Idaho National Engineering Laboratory

    SciTech Connect

    Green, J.R.

    1995-01-31

    This document was written in support of Environmental Assessment: Shutdown of the Fast Flux Test Facility (FFTF), Hanford Site, Richland, Washington. It analyzes the potential radiological risks associated with the transportation of sodium-bonded metal alloy and mixed carbide fuel from the FFTF on the Hanford Site in Washington State to the Idaho Engineering Laboratory in Idaho in the T-3 Cask. RADTRAN 4 is used for the analysis which addresses potential risk from normal transportation and hypothetical accident scenarios.

  1. Release of kinesin from vesicles by hsc70 and regulation of fast axonal transport

    NASA Technical Reports Server (NTRS)

    Tsai, M. Y.; Morfini, G.; Szebenyi, G.; Brady, S. T.

    2000-01-01

    The nature of kinesin interactions with membrane-bound organelles and mechanisms for regulation of kinesin-based motility have both been surprisingly difficult to define. Most kinesin is recovered in supernatants with standard protocols for purification of motor proteins, but kinesin recovered on membrane-bound organelles is tightly bound. Partitioning of kinesin between vesicle and cytosolic fractions is highly sensitive to buffer composition. Addition of either N-ethylmaleimide or EDTA to homogenization buffers significantly increased the fraction of kinesin bound to organelles. Given that an antibody against kinesin light chain tandem repeats also releases kinesin from vesicles, these observations indicated that specific cytoplasmic factors may regulate kinesin release from membranes. Kinesin light tandem repeats contain DnaJ-like motifs, so the effects of hsp70 chaperones were evaluated. Hsc70 released kinesin from vesicles in an MgATP-dependent and N-ethylmaleimide-sensitive manner. Recombinant kinesin light chains inhibited kinesin release by hsc70 and stimulated the hsc70 ATPase. Hsc70 actions may provide a mechanism to regulate kinesin function by releasing kinesin from cargo in specific subcellular domains, thereby effecting delivery of axonally transported materials.

  2. A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein

    NASA Technical Reports Server (NTRS)

    Ratner, N.; Bloom, G. S.; Brady, S. T.

    1998-01-01

    Proteins that interact with both cytoskeletal and membrane components are candidates to modulate membrane trafficking. The tumor suppressor proteins neurofibromin (NF1) and adenomatous polyposis coli (APC) both bind to microtubules and interact with membrane-associated proteins. The effects of recombinant NF1 and APC fragments on vesicle motility were evaluated by measuring fast axonal transport along microtubules in axoplasm from squid giant axons. APC4 (amino acids 1034-2844) reduced only anterograde movements, whereas APC2 (aa 1034-2130) or APC3 (aa 2130-2844) reduced both anterograde and retrograde transport. NF1 had no effect on organelle movement in either direction. Because APC contains multiple cyclin-dependent kinase (CDK) consensus phosphorylation motifs, the kinase inhibitor olomoucine was examined. At concentrations in which olomoucine is specific for cyclin-dependent kinases (5 microM), it reduced only anterograde transport, whereas anterograde and retrograde movement were both affected at concentrations at which other kinases are inhibited as well (50 microM). Both anterograde and retrograde transport also were inhibited by histone H1 and KSPXK peptides, substrates for proline-directed kinases, including CDKs. Our data suggest that CDK-like axonal kinases modulate fast anterograde transport and that other axonal kinases may be involved in modulating retrograde transport. The specific effect of APC4 on anterograde transport suggests a model in which the binding of APC to microtubules may limit the activity of axonal CDK kinase or kinases in restricted domains, thereby affecting organelle transport.

  3. Sink fast and swim harder! Round-trip cost-of-transport for buoyant divers.

    PubMed

    Miller, Patrick J O; Biuw, Martin; Watanabe, Yuuki Y; Thompson, Dave; Fedak, Mike A

    2012-10-15

    Efficient locomotion between prey resources at depth and oxygen at the surface is crucial for breath-hold divers to maximize time spent in the foraging layer, and thereby net energy intake rates. The body density of divers, which changes with body condition, determines the apparent weight (buoyancy) of divers, which may affect round-trip cost-of-transport (COT) between the surface and depth. We evaluated alternative predictions from external-work and actuator-disc theory of how non-neutral buoyancy affects round-trip COT to depth, and the minimum COT speed for steady-state vertical transit. Not surprisingly, the models predict that one-way COT decreases (increases) when buoyancy aids (hinders) one-way transit. At extreme deviations from neutral buoyancy, gliding at terminal velocity is the minimum COT strategy in the direction aided by buoyancy. In the transit direction hindered by buoyancy, the external-work model predicted that minimum COT speeds would not change at greater deviations from neutral buoyancy, but minimum COT speeds were predicted to increase under the actuator disc model. As previously documented for grey seals, we found that vertical transit rates of 36 elephant seals increased in both directions as body density deviated from neutral buoyancy, indicating that actuator disc theory may more closely predict the power requirements of divers affected by gravity than an external work model. For both models, minor deviations from neutral buoyancy did not affect minimum COT speed or round-trip COT itself. However, at body-density extremes, both models predict that savings in the aided direction do not fully offset the increased COT imposed by the greater thrusting required in the hindered direction. PMID:23014571

  4. Fast-ion transport in q{sub min}>2, high-β steady-state scenarios on DIII-D

    SciTech Connect

    Holcomb, C. T.; Heidbrink, W. W.; Collins, C.; Ferron, J. R.; Van Zeeland, M. A.; Garofalo, A. M.; Bass, E. M.; Luce, T. C.; Pace, D. C.; Solomon, W. M.; Mueller, D.; Grierson, B.; Podesta, M.; Gong, X.; Ren, Q.; Park, J. M.; Kim, K.; Turco, F.

    2015-05-15

    Results from experiments on DIII-D [J. L. Luxon, Fusion Sci. Technol. 48, 828 (2005)] aimed at developing high β steady-state operating scenarios with high-q{sub min} confirm that fast-ion transport is a critical issue for advanced tokamak development using neutral beam injection current drive. In DIII-D, greater than 11 MW of neutral beam heating power is applied with the intent of maximizing β{sub N} and the noninductive current drive. However, in scenarios with q{sub min}>2 that target the typical range of q{sub 95}= 5–7 used in next-step steady-state reactor models, Alfvén eigenmodes cause greater fast-ion transport than classical models predict. This enhanced transport reduces the absorbed neutral beam heating power and current drive and limits the achievable β{sub N}. In contrast, similar plasmas except with q{sub min} just above 1 have approximately classical fast-ion transport. Experiments that take q{sub min}>3 plasmas to higher β{sub P} with q{sub 95}= 11–12 for testing long pulse operation exhibit regimes of better than expected thermal confinement. Compared to the standard high-q{sub min} scenario, the high β{sub P} cases have shorter slowing-down time and lower ∇β{sub fast}, and this reduces the drive for Alfvénic modes, yielding nearly classical fast-ion transport, high values of normalized confinement, β{sub N}, and noninductive current fraction. These results suggest DIII-D might obtain better performance in lower-q{sub 95}, high-q{sub min} plasmas using broader neutral beam heating profiles and increased direct electron heating power to lower the drive for Alfvén eigenmodes.

  5. A FOCUSED TRANSPORT APPROACH TO THE TIME-DEPENDENT SHOCK ACCELERATION OF SOLAR ENERGETIC PARTICLES AT A FAST TRAVELING SHOCK

    SciTech Connect

    Le Roux, J. A.; Webb, G. M.

    2012-02-10

    Some of the most sophisticated models for solar energetic particle (SEP) acceleration at coronal mass ejection driven shocks are based on standard diffusive shock acceleration theory. However, this theory, which only applies when SEP pitch-angle anisotropies are small, might have difficulty in describing first-order Fermi acceleration or the shock pre-heating and injection of SEPs into first-order Fermi acceleration accurately at lower SEP speeds where SEP pitch-angle anisotropies upstream near the shock can be large. To avoid this problem, we use a time-dependent focused transport model to reinvestigate first-order Fermi acceleration at planar parallel and quasi-parallel spherical traveling shocks between the Sun and Earth with high shock speeds associated with rare extreme gradual SEP events. The focused transport model is also used to investigate and compare three different shock pre-heating mechanisms associated with different aspects of the nonuniform cross-shock solar wind flow, namely, the convergence of the flow (adiabatic compression), the shear tensor of the flow, and the acceleration of the flow, and a fourth shock pre-heating mechanism associated with the cross-shock electric field, to determine which pre-heating mechanism contributes the most to injecting shock pre-heated source particles into the first-order Fermi acceleration process. The effects of variations in traveling shock conditions, such as increasing shock obliquity and shock slowdown, and variations in the SEP source with increasing shock distance from the Sun on the coupled processes of shock pre-heating, injection, and first-order Fermi acceleration are analyzed. Besides the finding that the cross-shock acceleration of the solar wind flow yields the dominant shock pre-heating mechanism at high shock speeds, we find that first-order Fermi acceleration at fast traveling shocks differs in a number of respects from the predictions and assumptions of standard steady-state diffusive shock

  6. Experimental Transport Benchmarks for Physical Dosimetry to Support Development of Fast-Neutron Therapy with Neutron Capture Augmentation

    SciTech Connect

    D. W. Nigg; J. K. Hartwell; J. R. Venhuizen; C. A. Wemple; R. Risler; G. E. Laramore; W. Sauerwein; G. Hudepohl; A. Lennox

    2006-06-01

    The Idaho National Laboratory (INL), the University of Washington (UW) Neutron Therapy Center, the University of Essen (Germany) Neutron Therapy Clinic, and the Northern Illinois University(NIU) Institute for Neutron Therapy at Fermilab have been collaborating in the development of fast-neutron therapy (FNT) with concurrent neutron capture (NCT) augmentation [1,2]. As part of this effort, we have conducted measurements to produce suitable benchmark data as an aid in validation of advanced three-dimensional treatment planning methodologies required for successful administration of FNT/NCT. Free-beam spectral measurements as well as phantom measurements with Lucite{trademark} cylinders using thermal, resonance, and threshold activation foil techniques have now been completed at all three clinical accelerator facilities. The same protocol was used for all measurements to facilitate intercomparison of data. The results will be useful for further detailed characterization of the neutron beams of interest as well as for validation of various charged particle and neutron transport codes and methodologies for FNT/NCT computational dosimetry, such as MCNP [3], LAHET [4], and MINERVA [5].

  7. Enhanced Dopamine Release by Dopamine Transport Inhibitors Described by a Restricted Diffusion Model and Fast-Scan Cyclic Voltammetry.

    PubMed

    Hoffman, Alexander F; Spivak, Charles E; Lupica, Carl R

    2016-06-15

    Fast-scan cyclic voltammetry (FSCV) using carbon fiber electrodes is widely used to rapidly monitor changes in dopamine (DA) levels in vitro and in vivo. Current analytical approaches utilize parameters such as peak oxidation current amplitude and decay times to estimate release and uptake processes, respectively. However, peak amplitude changes are often observed with uptake inhibitors, thereby confounding the interpretation of these parameters. To overcome this limitation, we demonstrate that a simple five-parameter, two-compartment model mathematically describes DA signals as a balance of release (r/ke) and uptake (ku), summed with adsorption (kads and kdes) of DA to the carbon electrode surface. Using nonlinear regression, we demonstrate that our model precisely describes measured DA signals obtained in brain slice recordings. The parameters extracted from these curves were then validated using pharmacological manipulations that selectively alter vesicular release or DA transporter (DAT)-mediated uptake. Manipulation of DA release through altering the Ca(2+)/Mg(2+) ratio or adding tetrodotoxin reduced the release parameter with no effect on the uptake parameter. DAT inhibitors methylenedioxypyrovalerone, cocaine, and nomifensine significantly reduced uptake and increased vesicular DA release. In contrast, a low concentration of amphetamine reduced uptake but had no effect on DA release. Finally, the kappa opioid receptor agonist U50,488 significantly reduced vesicular DA release but had no effect on uptake. Together, these data demonstrate a novel analytical approach to distinguish the effects of manipulations on DA release or uptake that can be used to interpret FSCV data. PMID:27018734

  8. Impact of Pre-Plasma on Fast Electron Generation and Transport from Short Pulse High Intensity Lasers

    NASA Astrophysics Data System (ADS)

    Peebles, J.; McGuffey, C.; Krauland, C.; Jarrott, L. C.; Sorokovikova, A.; Qiao, B.; Krasheninnikov, S.; Beg, F. N.; Wei, M. S.; Park, J.; Link, A.; Chen, H.; McLean, H. S.; Wagner, C.; Minello, V.; McCary, E.; Meadows, A.; Spinks, M.; Gaul, E.; Dyer, G.; Hegelich, B. M.; Martinez, M.; Donovan, M.; Ditmire, T.

    2014-10-01

    We present the results and analysis from recent short pulse laser matter experiments using the Texas Petawatt Laser to study the impact of pre-plasma on fast electron generation and transport. The experimental setup consisted of 3 separate beam elements: a main, high intensity, short pulse beam for the interaction, a secondary pulse of equal intensity interacting with a separate thin foil target to generate protons for side-on proton imaging and a third, low intensity, wider beam to generate a varied scale length pre-plasma. The main target consisted of a multilayer planar Al foil with a buried Cu fluor layer. The electron beam was characterized with multiple diagnostics, including several bremsstrahlung spectrometers, magnetic electron spectrometers and Cu-K α imaging. The protons from the secondary target were used to image the fields on the front of the target in the region of laser plasma interaction. Features seen in the interaction region by these protons will be presented along with characteristics of the generated electron beam. This work performed under the auspices of the US DOE under Contracts DE-FOA-0000583 (FES, NNSA).

  9. The effect of biological shielding on fast neutron and photon transport in the VVER-1000 mock-up model placed in the LR-0 reactor.

    PubMed

    Košťál, Michal; Cvachovec, František; Milčák, Ján; Mravec, Filip

    2013-05-01

    The paper is intended to show the effect of a biological shielding simulator on fast neutron and photon transport in its vicinity. The fast neutron and photon fluxes were measured by means of scintillation spectroscopy using a 45×45 mm(2) and a 10×10 mm(2) cylindrical stilbene detector. The neutron spectrum was measured in the range of 0.6-10 MeV and the photon spectrum in 0.2-9 MeV. The results of the experiment are compared with calculations. The calculations were performed with various nuclear data libraries. PMID:23434890

  10. Transcriptome Analysis and Postprandial Expression of Amino Acid Transporter Genes in the Fast Muscles and Gut of Chinese Perch (Siniperca chuatsi)

    PubMed Central

    Chen, Lin; Zeng, Ming; Wu, Yuanan; Wang, Jianhua; Zhang, Jianshe

    2016-01-01

    The characterization of the expression and regulation of growth-related genes in the muscles of Chinese perch is of great interest to aquaculturists because of the commercial value of the species. The transcriptome annotation of the skeletal muscles is a crucial step in muscle growth-related gene analysis. In this study, we generated 52 504 230 reads of mRNA sequence data from the fast muscles of the Chinese perch by using Solexa/Illumina RNA-seq. Twenty-one amino acid transporter genes were annotated by searching protein and gene ontology databases, and postprandial changes in their transcript abundance were assayed after administering a single satiating meal to Chinese perch juveniles (body mass, approximately 100 g), following fasting for 1 week. The gut content of the Chinese perch increased significantly after 1 h and remained high for 6 h following the meal and emptied within 48–96 h. Expression of eight amino acid transporter genes was assayed in the fast muscles through quantitative real-time polymerase chain reaction at 0, 1, 3, 6, 12, 24, 48, and 96 h. Among the genes, five transporter transcripts were markedly up-regulated within 1 h of refeeding, indicating that they may be potential candidate genes involved in the rapid-response signaling system regulating fish myotomal muscle growth. These genes display coordinated regulation favoring the resumption of myogenesis responding to feeding. PMID:27463683

  11. Transcriptome Analysis and Postprandial Expression of Amino Acid Transporter Genes in the Fast Muscles and Gut of Chinese Perch (Siniperca chuatsi).

    PubMed

    Wu, Ping; Li, Yulong; Cheng, Jia; Chen, Lin; Zeng, Ming; Wu, Yuanan; Wang, Jianhua; Zhang, Jianshe; Chu, Wuying

    2016-01-01

    The characterization of the expression and regulation of growth-related genes in the muscles of Chinese perch is of great interest to aquaculturists because of the commercial value of the species. The transcriptome annotation of the skeletal muscles is a crucial step in muscle growth-related gene analysis. In this study, we generated 52 504 230 reads of mRNA sequence data from the fast muscles of the Chinese perch by using Solexa/Illumina RNA-seq. Twenty-one amino acid transporter genes were annotated by searching protein and gene ontology databases, and postprandial changes in their transcript abundance were assayed after administering a single satiating meal to Chinese perch juveniles (body mass, approximately 100 g), following fasting for 1 week. The gut content of the Chinese perch increased significantly after 1 h and remained high for 6 h following the meal and emptied within 48-96 h. Expression of eight amino acid transporter genes was assayed in the fast muscles through quantitative real-time polymerase chain reaction at 0, 1, 3, 6, 12, 24, 48, and 96 h. Among the genes, five transporter transcripts were markedly up-regulated within 1 h of refeeding, indicating that they may be potential candidate genes involved in the rapid-response signaling system regulating fish myotomal muscle growth. These genes display coordinated regulation favoring the resumption of myogenesis responding to feeding. PMID:27463683

  12. Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human

    PubMed Central

    Kulkarni, Supriya R.; Donepudi, Ajay C.; Xu, Jialin; Wei, Wei; Cheng, Qiuqiong C.; Driscoll, Maureen V.; Johnson, Delinda A.; Johnson, Jeffrey A.; Li, Xiaoling

    2014-01-01

    Abstract Aims: The purpose of this study was to determine whether 3′-5′-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) and Sirtuin-1 (SIRT1) dependent mechanisms modulate ATP-binding Cassette (ABC) transport protein expression. ABC transport proteins (ABCC2–4) are essential for chemical elimination from hepatocytes and biliary excretion. Nuclear factor-E2 related-factor 2 (NRF2) is a transcription factor that mediates ABCC induction in response to chemical inducers and liver injury. However, a role for NRF2 in the regulation of transporter expression in nonchemical models of liver perturbation is largely undescribed. Results: Here we show that fasting increased NRF2 target gene expression through NRF2- and SIRT1–dependent mechanisms. In intact mouse liver, fasting induces NRF2 target gene expression by at least 1.5 to 5-fold. In mouse and human hepatocytes, treatment with 8-Bromoadenosine-cAMP, a cAMP analogue, increased NRF2 target gene expression and antioxidant response element activity, which was decreased by the PKA inhibitor, H-89. Moreover, fasting induced NRF2 target gene expression was decreased in liver and hepatocytes of SIRT1 liver-specific null mice and NRF2-null mice. Lastly, NRF2 and SIRT1 were recruited to MAREs and Antioxidant Response Elements (AREs) in the human ABCC2 promoter. Innovation: Oxidative stress mediated NRF2 activation is well described, yet the influence of basic metabolic processes on NRF2 activation is just emerging. Conclusion: The current data point toward a novel role of nutrient status in regulation of NRF2 activity and the antioxidant response, and indicates that cAMP/PKA and SIRT1 are upstream regulators for fasting-induced activation of the NRF2-ARE pathway. Antioxid. Redox Signal. 20, 15–30. PMID:23725046

  13. Sawtooth-induced Fast-ion Transport in the DIII-D Tokamak: Observations and Comparison to Theory

    NASA Astrophysics Data System (ADS)

    Muscatello, C. M.; Heidbrink, W. W.; Pace, D. C.; Zhu, Y. B.; Kolesnichenko, Ya. I.; Lutsenko, V. V.; Yakovenko, Yu. V.; van Zeeland, M. A.; Fisher, R. K.; Tobias, B. J.

    2010-11-01

    Tokamak sawteeth consist of a reorganization of the plasma magnetic field and various plasma parameters. The extent to which the fast-ion distribution function F(x,v) is influenced can depend on the ions' distribution of pitch and energy as well as the nature of the crash. Recent sawtooth experiments at DIII-D employed the newly extended fast-ion deuterium-alpha (FIDA) diagnostic, 2D FIDA imaging, and the newly commissioned fast-ion loss detector. Consistent with theoretical predictions, the FIDA diagnostic indicates that passing particles are more strongly affected by a sawtooth crash than the trapped population. Furthermore, FIDA imaging reports a depletion of up to 50% of the central fast-ion density. Extensive experimental data provide a rigorous test bed of theoretical models.

  14. DEVELOPMENT AND EVALUATION OF A TRANSPORTABLE FAST GAS CHROMATOGRAPHY FOR THE MONITORING OF ORGANIC VAPORS IN AIR

    EPA Science Inventory

    Gas chromatography has the potential to be a real-time or near real-time monitoring method for organics in air. ransportable fast GC with FID/ECD and PID/ECD configurations has been developed. reliminary evaluation has shown that all design features and improvements of the instru...

  15. Study of dependence of fast electron transport on target material using the 10ps, 1.5kJ Omega EP laser

    NASA Astrophysics Data System (ADS)

    Sorokovikova, A.; Wei, M. S.; Stephens, R. B.; Jacquez, J.; Mishra, R.; Sawada, H.; Theobald, W.; Patel, P.; McLean, H.; Sentoku, Y.; Beg, F. N.

    2011-10-01

    Igniting a Fast Ignition (FI) target requires generation of hot electrons inside a cone tip that travel to the compressed fuel through the tip. Its material must withstand the shell implosion. The effect of different materials on electron transport was previously studied at the Titan laser (150 J 0.7ps); emission from a buried fluor characterized the laser-generated electrons transmission through Al, Mo, or Au. Recent experiments using the OMEGA EP (300 J, 1 ps) showed similar effects on transport--going from Al to Au halved the detected electrons and decreased their divergence. We have extended these experiments to 10 ps, 1.5 kJ pulses to study pulse length effects. Experiments are modeled using both collisional and hybrid PIC codes. Detailed results will be presented. Supported by US DOE contracts DE-NA0000870, DE-FG02-05ER54834, DE-FC02-04ER54789.

  16. The mechanisms of fast and slow transport in neurons: identification and characterization of the new kinesin superfamily motors.

    PubMed

    Hirokawa, N

    1997-10-01

    Progress in the identification and characterization of new carboxy-terminal motor domain type kinesin superfamily proteins (KIFs)-KIFC2, 16 new KIFs and KIF-associated protein 3 (KAP3)-has provided further insight into the molecular mechanisms of organelle transport in neurons. Developments in molecular and cellular biophysics and recombinant adenovirus infection techniques combined with transgenic mice technology have enhanced the visualization of moving forms of cytoskeletal proteins during slow transport. The results of these studies strongly support the subunit transport theory. PMID:9384541

  17. Post-scram Liquid Metal cooled Fast Breeder Reactor (LMFBR) heat transport system dynamics and steam generator control: Figures

    NASA Astrophysics Data System (ADS)

    Brukx, J. F. L. M.

    1982-06-01

    Dynamic modeling of LMFBR heat transport system is discussed. Uncontrolled transient behavior of individual components and of the integrated heat transport system are considered. For each component, results showing specific dynamic features of the component and/or model capability were generated. Controlled dynamic behavior for alternative steam generator control systems during forced and natural sodium coolant circulation was analyzed. Combined free and forced convection of laminar and turbulent vertical pipe flow of liquid metals was investigated.

  18. Post-scram Liquid Metal cooled Fast Breeder Reactor (LMFBR) neat transport system dynamics and steam generator control

    NASA Astrophysics Data System (ADS)

    Brukx, J. F. L. M.

    1982-06-01

    Loop type LMFBR heat transport system dynamics after reactor shutdown and during subsequent decay heat removal are considered with emphasis on steam generator dynamics including the development and evaluation of various post-scram steam generator control systems, and natural circulation of the sodium coolant, including the influence of superimposed free convection on forced convection heat transfer and pressure drop. The normal operating and decay heat removal functions of the overall heat transport system are described.

  19. Biorelevant media for transport experiments in the Caco-2 model to evaluate drug absorption in the fasted and the fed state and their usefulness.

    PubMed

    Markopoulos, C; Thoenen, F; Preisig, D; Symillides, M; Vertzoni, M; Parrott, N; Reppas, C; Imanidis, G

    2014-04-01

    In this work we developed and characterized transport media that simulate the composition of micellar phase of intestinal fluids in the fasted and, especially, in the fed state and are appropriate for evaluating intestinal drug permeability characteristics using the Caco-2 model (FaSSIF-TM(Caco) and FeSSIF-TM(Caco), respectively). Media composition was based on FaSSIF-V2 and FeSSIF-V2 and recently reported data on total lipid concentrations in the micellar phase of contents of the upper small intestine in the fasted and the fed state and was adapted for cell culture compatibility. Permeation data were evaluated by compartmental kinetic modeling. Permeability coefficients, P, of hydrophilic drugs were not affected by media composition. In contrast, P values of a series of lipophilic compounds measured with FaSSIF-TM(Caco) and FeSSIF-TM(Caco), and reflecting transport by diffusion were smaller than those obtained with a purely aqueous reference transport medium, aq-TM(Caco), following the rank order aq-TM(Caco)>FaSSIF-TM(Caco)>FeSSIF-TM(Caco). The decline of permeability values was stronger as lipophilicity of the compounds increased. Compared with values estimated using aq-TM(Caco), permeability was reduced, depending on the compound, by more than 20- to 100-fold when measured with FeSSIF-TM(Caco) whereas compound ranking in regard to the permeability characteristics was also affected. The impact of reduced P value on flux through the mucosa, hence on drug absorption, in combination with the drug amount loaded on colloidal particles needs to be taken into consideration in PBPK modeling especially when the food effect is evaluated. PMID:24184673

  20. The China Clipper - Fast advective transport of radon-rich air from the Asian boundary layer to the upper troposphere near California

    NASA Technical Reports Server (NTRS)

    Kritz, Mark A.; Le Roulley, Jean-Claude; Danielsen, Edwin F.

    1990-01-01

    A series of upper tropospheric radon concentration measurements made over the eastern Pacific and west coast of the U.S. during the summers of 1983 and 1984 has revealed the occurrence of unexpectedly high radon concentrations for 9 of the 61 measurements. A frequency distribution plot of the set of 61 observations shows a distinct bimodal distribution, with approximately 2/5 of the observations falling close to 1 pCi/SCM, and 3/5 falling in a high concentration mode centered at about 11 pCi/SCM. Trajectory and synoptic analyses for two of the flights on which such high radon concentrations were observed indicate that this radon-rich air originated in the Asian boundary layer, ascended in cumulus updrafts, and was carried eastward in the fast moving air on the anticyclonic side of the upper tropospheric jet. The results suggest that the combination of rapid vertical transport from the surface boundary layer to the upper troposphere, followed by rapid horizontal transport eastward represents an efficient mode of long-transport for other, chemically reactive atmospheric trace constituents.

  1. Transportation.

    ERIC Educational Resources Information Center

    Crank, Ron

    This instructional unit is one of 10 developed by students on various energy-related areas that deals specifically with transportation and energy use. Its objective is for the student to be able to discuss the implication of energy usage as it applies to the area of transportation. Some topics covered are efficiencies of various transportation…

  2. Evaluation of moisture and heat transport in the fast-response building-resolving urban transport code QUIC EnvSim

    NASA Astrophysics Data System (ADS)

    Briggs, Kevin A.

    QUIC EnvSim (QES) is a complete building-resolving urban microclimate modeling system developed to rapidly compute mass, momentum, and heat transport for the design of sustainable cities. One of the more computationally intensive components of this type of modeling system is the transport and dispersion of scalars. In this paper, we describe and evaluate QESTransport, a Reynolds-averaged Navier-Stokes (RANS) scalar transport model. QESTransport makes use of light-weight methods and modeling techniques. It is parallelized for Graphics Processing Units (GPUs), utilizing NVIDIA's OptiX application programming interfaces (APIs). QESTransport is coupled with the well-validated QUIC Dispersion Modeling system. To couple the models, a new methodology was implemented to efficiently prescribe surface flux boundary conditions on both vertical walls and flat surfaces. In addition, a new internal boundary layer parameterization was introduced into QUIC to enable the representation of momentum advection across changing surface conditions. QESTransport is validated against the following three experimental test cases designed to evaluate the model's performance under idealized conditions: (i) flow over a step change in moisture, roughness, and temperature, (ii) flow over an isolated heated building, and (iii) flow through an array of heated buildings. For all three cases, the model is compared against published simulation results. QESTransport produces velocity, temperature, and moisture fields that are comparable to much more complex numerical models for each case. The code execution time performance is evaluated and demonstrates linear scaling on a single GPU for problem sizes up to 4.5 x 4.5 km at 5 m grid resolution, and is found to produce results at much better than real time for a 1.2 x 1.2 km section of downtown Salt Lake City, Utah.

  3. Risk assessment of the fatality due to explosion in land mass transport infrastructure by fast transient dynamic analysis.

    PubMed

    Giannopoulos, G; Larcher, M; Casadei, F; Solomos, G

    2010-01-15

    Terrorist attacks in New York have shocked the world community showing clearly the vulnerability of air transport in such events. However, the terrorist attacks in Madrid and London showed that land mass transport infrastructure is equally vulnerable in case of similar attacks. The fact that there has not been substantial investment in the domain of risk analysis and evaluation of the possible effects due to such events in land mass transportation infrastructure leaves large room for new developments that could eventually fill this gap. In the present work using the finite element code EUROPLEXUS there has been a large effort to perform a complete study of the land mass infrastructure in case of explosion events. This study includes a train station, a metro station and a metro carriage providing thus valuable simulation data for a variety of different situations. For the analysis of these structures it has been necessary to apply a laser scanning method for the acquisition of geometrical data, to improve the simulation capabilities of EUROPLEXUS by adding failure capabilities for specific finite elements, to implement new material models (e.g. glass), and to add new modules that achieve data post-processing for the calculation of fatal and non-fatal injuries risk. The aforementioned improvements are explained in the present work with emphasis in the newly developed risk analysis features of EUROPLEXUS. PMID:19773121

  4. Fast Neutron Transport in the Biological Shielding Model and Other Regions of the VVER-1000 Mock-Up on the LR-0 Research Reactor

    NASA Astrophysics Data System (ADS)

    Košťál, Michal; Milčák, Ján; Cvachovec, František; Jánský, Bohumil; Rypar, Vojtěch; Juříček, Vlastimil; Novák, Evžen; Egorov, Alexander; Zaritskiy, Sergey

    2016-02-01

    A set of benchmark experiments was carried out in the full scale VVER-1000 mock-up on the reactor LR-0 in order to validate neutron transport calculation methodologies and to perform the optimization of the shape and locations of neutron flux operation monitors channels inside the shielding of the new VVER-1000 type reactors. Compared with previous experiments on the VVER-1000 mock-up on the reactor LR-0, the fast neutron spectra were measured in the extended neutron energy interval (0.1-10 MeV) and new calculations were carried out with the MCNPX code using various nuclear data libraries (ENDF/B VII.0, JEFF 3.1, JENDL 3.3, JENDL 4, ROSFOND 2009, and CENDL 3.1). Measurements and calculations were carried out at different points in the mock-up. The calculation and experimental data are compared.

  5. Investigations on the heat transport capability of a cryogenic oscillating heat pipe and its application in achieving ultra-fast cooling rates for cell vitrification cryopreservation☆

    PubMed Central

    Han, Xu; Ma, Hongbin; Jiao, Anjun; Critser, John K.

    2010-01-01

    Theoretically, direct vitrification of cell suspensions with relatively low concentrations (~1 M) of permeating cryoprotective agents (CPA) is suitable for cryopreservation of almost all cell types and can be accomplished by ultra-fast cooling rates that are on the order of 106–7 K/min. However, the methods and devices currently available for cell cryopreservation cannot achieve such high cooling rates. In this study, we constructed a novel cryogenic oscillating heat pipe (COHP) using liquid nitrogen as its working fluid and investigated its heat transport capability to assess its application for achieving ultra-fast cooling rates for cell cryopreservation. The experimental results showed that the apparent heat transfer coefficient of the COHP can reach 2 × 105 W/m2·K, which is two orders of the magnitude higher than traditional heat pipes. Theoretical analyzes showed that the average local heat transfer coefficient in the thin film evaporation region of the COHP can reach 1.2 × 106 W/m2·K, which is approximately 103 times higher than that achievable with standard pool-boiling approaches. Based on these results, a novel device design applying the COHP and microfabrication techniques is proposed and its efficiency for cell vitrification is demonstrated through numerical simulation. The estimated average cooling rates achieved through this approach is 106–7 K/min, which is much faster than the currently available methods and sufficient for achieving vitrification with relatively low concentrations of CPA. PMID:18430413

  6. The Shortlist Method for Fast Computation of the Earth Mover's Distance and Finding Optimal Solutions to Transportation Problems

    PubMed Central

    Gottschlich, Carsten; Schuhmacher, Dominic

    2014-01-01

    Finding solutions to the classical transportation problem is of great importance, since this optimization problem arises in many engineering and computer science applications. Especially the Earth Mover's Distance is used in a plethora of applications ranging from content-based image retrieval, shape matching, fingerprint recognition, object tracking and phishing web page detection to computing color differences in linguistics and biology. Our starting point is the well-known revised simplex algorithm, which iteratively improves a feasible solution to optimality. The Shortlist Method that we propose substantially reduces the number of candidates inspected for improving the solution, while at the same time balancing the number of pivots required. Tests on simulated benchmarks demonstrate a considerable reduction in computation time for the new method as compared to the usual revised simplex algorithm implemented with state-of-the-art initialization and pivot strategies. As a consequence, the Shortlist Method facilitates the computation of large scale transportation problems in viable time. In addition we describe a novel method for finding an initial feasible solution which we coin Modified Russell's Method. PMID:25310106

  7. The Shortlist Method for fast computation of the Earth Mover's Distance and finding optimal solutions to transportation problems.

    PubMed

    Gottschlich, Carsten; Schuhmacher, Dominic

    2014-01-01

    Finding solutions to the classical transportation problem is of great importance, since this optimization problem arises in many engineering and computer science applications. Especially the Earth Mover's Distance is used in a plethora of applications ranging from content-based image retrieval, shape matching, fingerprint recognition, object tracking and phishing web page detection to computing color differences in linguistics and biology. Our starting point is the well-known revised simplex algorithm, which iteratively improves a feasible solution to optimality. The Shortlist Method that we propose substantially reduces the number of candidates inspected for improving the solution, while at the same time balancing the number of pivots required. Tests on simulated benchmarks demonstrate a considerable reduction in computation time for the new method as compared to the usual revised simplex algorithm implemented with state-of-the-art initialization and pivot strategies. As a consequence, the Shortlist Method facilitates the computation of large scale transportation problems in viable time. In addition we describe a novel method for finding an initial feasible solution which we coin Modified Russell's Method. PMID:25310106

  8. Fast changes in chemical composition and size distribution of fine particles during the near-field transport of industrial plumes.

    PubMed

    Marris, Hélène; Deboudt, Karine; Augustin, Patrick; Flament, Pascal; Blond, François; Fiani, Emmanuel; Fourmentin, Marc; Delbarre, Hervé

    2012-06-15

    Aerosol sampling was performed inside the chimneys and in the close environment of a FeMn alloys manufacturing plant. The number size distributions show a higher abundance of ultrafine aerosols (10-100 nm) inside the plume than upwind of the plant, indicating the emissions of nanoparticles by the industrial process. Individual analysis of particles collected inside the plume shows a high proportion of metal bearing particles (Mn-/Fe-) consisting essentially of internally mixed aluminosilicate and metallic compounds. These particles evolve rapidly (in a few minutes) after emission by adsorption of VOC gas and sulfuric acid emitted by the plant but also by agglomeration with pre-existing particles. At the moment, municipalities require a monitoring of industrial emissions inside the chimneys from manufacturers. However those measures are insufficient to report such rapid changes in chemical composition and thus to evaluate the real impact of industrial plumes in the close environment of plants (when those particles leave the industrial site). Consequently, environmental authorities will have to consider such fast evolutions and then to adapt future regulations on air pollution sources. PMID:22542297

  9. Impact of pre-plasma on fast electron generation and transport from short pulse, high intensity lasers

    NASA Astrophysics Data System (ADS)

    Peebles, J.; McGuffey, C.; Krauland, C. M.; Jarrott, L. C.; Sorokovikova, A.; Wei, M. S.; Park, J.; Chen, H.; McLean, H. S.; Wagner, C.; Spinks, M.; Gaul, E. W.; Dyer, G.; Hegelich, B. M.; Martinez, M.; Donovan, M.; Ditmire, T.; Krasheninnikov, S. I.; Beg, F. N.

    2016-01-01

    Previous experiments and modeling examining the impact of an underdense, pre-formed plasma in laser-plasma interactions have shown that the fast electrons are generated with energies higher than predicted by ponderomotive scaling [4, 3-14]. We report on experiments using the Texas Petawatt high intensity (150 fs, 1.5  ×  1020 W cm-2) laser pulse, which were conducted to examine the mechanism for accelerating these high energy electrons. These experiments gauge the impact a controlled low density pre-formed plasma has on electron generation with a shorter time scale than previous experiments, 150-180 fs. Electron temperatures measured via magnetic spectrometer on experiment were found to be independent of preformed plasma. Supplemental computational results using 1D PIC simulations predict that super-ponderomotive electrons are generated inside a potential well in the pre-plasma [1]. However, while the potential well is established around 150 fs, the electrons require at least an additional 50 fs to be trapped and heated inside it.

  10. Fast-electron source characterization and transport in high-intensity laser-solid interactions and the role of resistive magnetic fields

    NASA Astrophysics Data System (ADS)

    Storm, Michael

    An electron transport regime is identified in which >1 MA, relativistic currents, generated by high-intensity, laser-target interactions, are collimated (or focused) by self-generated, resistive, magnetic fields within solid-density targets. The strongest magnetic fields appear at the edge of the electric current due to the radial shear in the current density. High-resolution coherent transition radiation (CTR) imaging of the target rear surface diagnoses the electrons that are accelerated from the target front surface by a laser that is focused to an intensity of I ˜ 10 19 Wcm-2. CTR is emitted when an electron beam, with longitudinal electron density modulations, crosses a refractive index interface such as the target rear surface. A fast electron temperature of T hot = 1.4 +/- 0.1 MeV is inferred from variations in the radiated CTR energy with target thickness. Variation in the CTR emitted energy with laser intensity obeys the power law ECTR ∝ I5.7 +/- 0.5. These results are consistent with the predictions of the ponderomotive scaling law. The high resolution images show the presence of bright, micron-scale structures in the CTR emission that indicate that the electron beam filaments. The micron scale structures are superimposed onto larger annular structures that suggest the electron beam hollows as it propagates. The variation in the spatial extent of the CTR emission with increasing target thickness gives an electron beam angular divergence of theta1/2 = 15.7 +/- 0.9°. Three-dimensional, hybrid-particle-in-cell code simulations of the electron transport indicate a target rear-surface electron density distribution that reproduces the details of the CTR emission seen in the experiments. The variation of the electron density distribution with increasing target thickness resembles an expanding annulus that breaks into filaments due to the resistive filamentation instability. The radially expanding annular pattern results from the partial collimation of an

  11. Highly Repeatable and Recoverable Phototransistors Based on Multifunctional Channels of Photoactive CdS, Fast Charge Transporting ZnO, and Chemically Durable Al2O3 Layers.

    PubMed

    Ahn, Cheol Hyoun; Kang, Won Jun; Kim, Ye Kyun; Yun, Myeong Gu; Cho, Hyung Koun

    2016-06-22

    Highly repeatable and recoverable phototransistors were explored using a "multifunctional channels" structure with multistacked chalcogenide and oxide semiconductors. These devices were made of (i) photoactive CdS (with a visible band gap), (ii) fast charge transporting ZnO (with a high field-effect mobility), and (iii) a protection layer of Al2O3 (with high chemical durability). The CdS TFT without the Al2O3 protection layer did not show a transfer curve due to the chemical damage that occurred on the ZnO layer during the chemical bath deposition (CBD) process used for CdS deposition. Alternatively, compared to CdS phototransistors with long recovery time and high hysteresis (ΔVth = 19.5 V), our "multi-functional channels" phototransistors showed an extremely low hysteresis loop (ΔVth = 0.5V) and superior photosensitivity with repeatable high photoresponsivity (52.9 A/W at 400 nm). These improvements are likely caused by the physical isolation of the sensing region and charge transport region by the insertion of the ultrathin Al2O3 layer. This approach successfully addresses some of the existing problems in CdS phototransistors, such as the high gate-interface trap site density and high absorption of molecular oxygen, which originate from the polycrystalline CdS. PMID:27259048

  12. R_transport_matrices of the Fast Extraction Beam (FEB) of the AGS, and Beam Parameters at the Starting point of the AtR Line

    SciTech Connect

    Tsoupas,N.; MacKay, W.W.; Satogata, T.; Glenn, W.; Ahrens, L.; Brown, K.; Gardner, C.; Tanaka, S.

    2008-01-01

    As part of the task to improve and further automate the 'AtR BPM Application' we provide the theoretically calculated R-transport-matrices for the following beam line sections, which are shown schematically in Figure 1: (a) the Fast Extraction Beam section (FEB) of the AGS synchrotron. The FEB section starts at the middle of the GlO-kicker and ends at the middle of the H1 0{_}septum. (b) the Drift Extraction Channel (DEC) section of the AGS synchrotron. The DEC section starts at the middle of the H10{_}septum, continues along the fringe field region of the H11,H12, and H13 AGS main magnets, and ends at the starting point of the AtR line. The knowledge of these R-transport-matrices are needed in order to calculate the beam parameters at the beginning of the AtR line, which in turn, are required to calculate the magnet settings of the U{_}line, that match the U{_}line into the W{_}line. Also by incorporating these R{_}matrices into the model of the AtR line, the G10 kicker and the H10 septum are included in the AtR model therefore one can investigate any 'jitter' of either the GlO{_}kicker or HlO{_}septum by looking at the trajectory of the beam in the AtR line.

  13. Status report on the Small Secure Transportable Autonomous Reactor (SSTAR) /Lead-cooled Fast Reactor (LFR) and supporting research and development.

    SciTech Connect

    Sienicki, J. J.; Moisseytsev, A.; Yang, W. S.; Wade, D. C.; Nikiforova, A.; Hanania, P.; Ryu, H. J.; Kulesza, K. P.; Kim, S. J.; Halsey, W. G.; Smith, C. F.; Brown, N. W.; Greenspan, E.; de Caro, M.; Li, N.; Hosemann, P.; Zhang, J.; Yu, H.; Nuclear Engineering Division; LLNL; LANL; Massachusetts Inst. of Tech.; Ecole des Mines de Paris; Oregon State Univ.; Univ.of California at Berkley

    2008-06-23

    This report provides an update on development of a pre-conceptual design for the Small Secure Transportable Autonomous Reactor (SSTAR) Lead-Cooled Fast Reactor (LFR) plant concept and supporting research and development activities. SSTAR is a small, 20 MWe (45 MWt), natural circulation, fast reactor plant for international deployment concept incorporating proliferation resistance for deployment in non-fuel cycle states and developing nations, fissile self-sufficiency for efficient utilization of uranium resources, autonomous load following making it suitable for small or immature grid applications, and a high degree of passive safety further supporting deployment in developing nations. In FY 2006, improvements have been made at ANL to the pre-conceptual design of both the reactor system and the energy converter which incorporates a supercritical carbon dioxide Brayton cycle providing higher plant efficiency (44 %) and improved economic competitiveness. The supercritical CO2 Brayton cycle technology is also applicable to Sodium-Cooled Fast Reactors providing the same benefits. One key accomplishment has been the development of a control strategy for automatic control of the supercritical CO2 Brayton cycle in principle enabling autonomous load following over the full power range between nominal and essentially zero power. Under autonomous load following operation, the reactor core power adjusts itself to equal the heat removal from the reactor system to the power converter through the large reactivity feedback of the fast spectrum core without the need for motion of control rods, while the automatic control of the power converter matches the heat removal from the reactor to the grid load. The report includes early calculations for an international benchmarking problem for a LBE-cooled, nitride-fueled fast reactor core organized by the IAEA as part of a Coordinated Research Project on Small Reactors without Onsite Refueling; the calculations use the same neutronics

  14. Ion/electron coupled transport through polyaniline membrane: fast transmembrane redox reactions at neutral pH.

    PubMed

    Kocherginsky, Nikolai M; Wang, Zheng

    2008-06-12

    Different oxidizing and reducing agents can be separated by a solid polymer membrane, but they still react. The possibility to conduct this type of transmembrane redox reactions coupled with electroneutral electron/chloride countertransport is demonstrated here for polyaniline (PANI) membrane doped with camphor sulfonic acid (CSA). For the 80 microm film, the transmembrane reaction rate can be as high as 5 x 10 (-8) mol/(cm (2) s) with FeCl 3 as the oxidizing and ascorbic acid as the reducing agents, which is approximately 25 times higher than described by us earlier with HCl-doped PANI membrane. Both solutions separated by the membrane with CSA can have pH near neutral, which is impossible with HCl-doping. Advanced kinetic mechanism of electron/ion coupled transport including chloride equilibrium at the interface is proposed, and major kinetic parameters are estimated. Interfacial redox rate constants (cm/s) are compared with the rate constants determined for polarized membranes by electrochemical methods and also with usual first and second order rate constants in the bulk volume. Possibility to conduct different redox reactions between substances which are not mixed and are separated by a membrane makes this new process very attractive for chemical and environmental engineering. PMID:18489136

  15. MO-A-BRD-10: A Fast and Accurate GPU-Based Proton Transport Monte Carlo Simulation for Validating Proton Therapy Treatment Plans

    SciTech Connect

    Wan Chan Tseung, H; Ma, J; Beltran, C

    2014-06-15

    Purpose: To build a GPU-based Monte Carlo (MC) simulation of proton transport with detailed modeling of elastic and non-elastic (NE) protonnucleus interactions, for use in a very fast and cost-effective proton therapy treatment plan verification system. Methods: Using the CUDA framework, we implemented kernels for the following tasks: (1) Simulation of beam spots from our possible scanning nozzle configurations, (2) Proton propagation through CT geometry, taking into account nuclear elastic and multiple scattering, as well as energy straggling, (3) Bertini-style modeling of the intranuclear cascade stage of NE interactions, and (4) Simulation of nuclear evaporation. To validate our MC, we performed: (1) Secondary particle yield calculations in NE collisions with therapeutically-relevant nuclei, (2) Pencil-beam dose calculations in homogeneous phantoms, (3) A large number of treatment plan dose recalculations, and compared with Geant4.9.6p2/TOPAS. A workflow was devised for calculating plans from a commercially available treatment planning system, with scripts for reading DICOM files and generating inputs for our MC. Results: Yields, energy and angular distributions of secondaries from NE collisions on various nuclei are in good agreement with the Geant4.9.6p2 Bertini and Binary cascade models. The 3D-gamma pass rate at 2%–2mm for 70–230 MeV pencil-beam dose distributions in water, soft tissue, bone and Ti phantoms is 100%. The pass rate at 2%–2mm for treatment plan calculations is typically above 98%. The net computational time on a NVIDIA GTX680 card, including all CPU-GPU data transfers, is around 20s for 1×10{sup 7} proton histories. Conclusion: Our GPU-based proton transport MC is the first of its kind to include a detailed nuclear model to handle NE interactions on any nucleus. Dosimetric calculations demonstrate very good agreement with Geant4.9.6p2/TOPAS. Our MC is being integrated into a framework to perform fast routine clinical QA of pencil

  16. A Focused Transport Approach to SEP acceleration at a Fast Parallel Shock in the Corona Including Self-excitation of Alfvén Waves

    NASA Astrophysics Data System (ADS)

    le Roux, J. A.

    2012-12-01

    It has been argued that the acceleration of SEPS at a quasi-parallel CME-driven shock to GeV energies in the corona only occurs if strong wave-excitation by SEPs ahead of the shock reduces the parallel mean free path upstream, thus boosting the rate of diffusive shock acceleration. To investigate this issue, we modeled SEP acceleration at a fast parallel traveling shock in the corona with an existing time-dependent focused transport model. The model has been expanded recently to also feature time-dependent self-excitation and damping of Alfvén waves by SEP anisotropies ahead of the shock based on standard quasi-linear theory. Alfvén wave propagation near the traveling shock is modeled based on standard theory for wave transport in a slowly varying non-uniform plasma medium. Preliminary results will be shown to illustrate the increase in wave power driven by SEP anisotropies upstream, the effect of the shock wave in shortening the wave length and increasing the wave amplitude of Alfvén waves, and the associated acceleration of SEPs by 1st order Fermi acceleration to high energies. The role of the acceleration of the cross-shock solar wind flow, which was found to create a downstream population of shock pre-heated particles which forms an additional source for injection into 1st order Fermi acceleration, will be discussed in terms of how it affects self-excitation of Alfvén waves and the formation of high-energy SEPs by 1st order Fermi acceleration.

  17. Reducing The Cost of Transport and Increasing Walking Distance After Stroke: A Randomized Controlled Trial on Fast Locomotor Training Combined With Functional Electrical Stimulation.

    PubMed

    Awad, Louis N; Reisman, Darcy S; Pohlig, Ryan T; Binder-Macleod, Stuart A

    2016-08-01

    Background Neurorehabilitation efforts have been limited in their ability to restore walking function after stroke. Recent work has demonstrated proof-of-concept for a functional electrical stimulation (FES)-based combination therapy designed to improve poststroke walking by targeting deficits in paretic propulsion. Objectives To determine the effects on the energy cost of walking (EC) and long-distance walking ability of locomotor training that combines fast walking with FES to the paretic ankle musculature (FastFES). Methods Fifty participants >6 months poststroke were randomized to 12 weeks of gait training at self-selected speeds (SS), fast speeds (Fast), or FastFES. Participants' 6-minute walk test (6MWT) distance and EC at comfortable (EC-CWS) and fast (EC-Fast) walking speeds were measured pretraining, posttraining, and at a 3-month follow-up. A reduction in EC-CWS, independent of changes in speed, was the primary outcome. Group differences in the number of 6MWT responders and moderation by baseline speed were also evaluated. Results When compared with SS and Fast, FastFES produced larger reductions in EC (Ps ≤.03). FastFES produced reductions of 24% and 19% in EC-CWS and EC-Fast (Ps <.001), respectively, whereas neither Fast nor SS influenced EC. Between-group 6MWT differences were not observed; however, 73% of FastFES and 68% of Fast participants were responders, in contrast to 35% of SS participants. Conclusions Combining fast locomotor training with FES is an effective approach to reducing the high EC of persons poststroke. Surprisingly, differences in 6MWT gains were not observed between groups. Closer inspection of the 6MWT and EC relationship and elucidation of how reduced EC may influence walking-related disability is warranted. PMID:26621366

  18. Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport.

    PubMed

    Tiernan, Chelsea T; Combs, Benjamin; Cox, Kristine; Morfini, Gerardo; Brady, Scott T; Counts, Scott E; Kanaan, Nicholas M

    2016-09-01

    In Alzheimer's disease (AD), tau undergoes numerous modifications, including increased phosphorylation at serine-422 (pS422). In the human brain, pS422 tau protein is found in prodromal AD, correlates well with cognitive decline and neuropil thread pathology, and appears associated with increased oligomer formation and exposure of the N-terminal phosphatase-activating domain (PAD). However, whether S422 phosphorylation contributes to toxic mechanisms associated with disease-related forms of tau remains unknown. Here, we report that S422-pseudophosphorylated tau (S422E) lengthens the nucleation phase of aggregation without altering the extent of aggregation or the types of aggregates formed. When compared to unmodified tau aggregates, the S422E modification significantly increased the amount of SDS-stable tau dimers, despite similar levels of immunoreactivity with an oligomer-selective antibody (TOC1) and another antibody that reports PAD exposure (TNT1). Vesicle motility assays in isolated squid axoplasm further revealed that S422E tau monomers inhibited anterograde, kinesin-1 dependent fast axonal transport (FAT). Unexpectedly, and unlike unmodified tau aggregates, which selectively inhibit anterograde FAT, aggregates composed of S422E tau were found to inhibit both anterograde and retrograde FAT. Highlighting the relevance of these findings to human disease, pS422 tau was found to colocalize with tau oligomers and with a fraction of tau showing increased PAD exposure in the human AD brain. This study identifies novel effects of pS422 on tau biochemical properties, including prolonged nucleation and enhanced dimer formation, which correlate with a distinct inhibitory effect on FAT. Taken together, these findings identify a novel mechanistic basis by which pS422 confers upon tau a toxic effect that may directly contribute to axonal dysfunction in AD and other tauopathies. PMID:27373205

  19. Accumulation of [3H]fucose-labelled glycoproteins in the Golgi apparatus of dorsal root ganglion neurons during inhibition of fast axonal transport caused by exposure of the ganglion to Co2+-containing or Ca2+-free medium.

    PubMed

    Lavoie, P A; Bennett, G

    1983-01-01

    Previous in vitro studies have established that Co2+-containing or Ca2+-free media interfere with the initiation of the fast axonal transport of proteins. The present study has used light- and electron-microscope radioautography to compare the distribution of [3H]fucose-labelled glycoproteins in neuronal cell bodies of control dorsal root ganglia and ganglia incubated for 16-17 h in Ca2+-free medium or in medium containing 0.18 mM Co2+. The radioautographic reaction in control cell bodies was diffusely scattered throughout the cytoplasm; grain counts revealed that 22% of the reaction was associated with elements of the Golgi apparatus and 78% was over other organelles and the remainder of the cytoplasm. In most experimental cell bodies, 78% of the silver grains were clustered over elements of the Golgi complex whereas other organelles and the remainder of the cytoplasm were comparatively much less labelled; structural alterations of the Golgi apparatus were also produced by the modified media. In parallel studies where the radioactivity in nerve trunks and ganglia was measured by liquid scintillation counting, it was found that the Ca2+-free medium and the Co2+-containing medium both reduced by approximately 80% the quantity of [3H]fucose-labelled glycoproteins which were carried by the fast axonal transport system; they did so without interfering with the incorporation of [3H]fucose into glycoproteins. The results indicate that in the presence of Co2+ or in the absence of Ca2+ the proteins which are destined for fast axonal transport accumulate at the Golgi apparatus of neuronal cell bodies. These results thus suggest that Ca2+ is required for proteins to leave the Golgi region in transit to the fast axonal transport system. PMID:6188994

  20. Intermodal Transportation: Current Fast Ship Designs Specify Propulsion Systems that Are about 20 Knots Faster than Ships in the Current Fleet

    ERIC Educational Resources Information Center

    Childress, Vincent W.

    2005-01-01

    Intermodal transportation is the moving of people or cargo using more than one mode of transportation. When a person drives to the airport, stands on a conveyor to move through the terminal, and flies to another city, then he or she is using intermodal transportation. Moving cargo in the first half of the twentieth century was a time-consuming and…

  1. Spatial kinetics in fast reactors

    NASA Astrophysics Data System (ADS)

    Seleznev, E. F.; Belov, A. A.; Panova, I. S.; Matvienko, I. P.; Zhukov, A. M.

    2013-12-01

    The analysis of the solution to the spatial nonstationary equation of neutron transport is presented by the example of a fast reactor. Experiments in spatial kinetics conducted recently at the complex of critical assemblies (fast physical stand) and computations of their data using the TIMER code (for solving the nonstationary equation in multidimensional diffusion approximation for direct and inverse problems of reactor kinetics) have shown that kinetics of fast reactors substantially differs from kinetics of thermal reactors. The difference is connected with influence of the delayed neutron spectrum on rates of the process in a fast reactor.

  2. Fast valve

    DOEpatents

    Van Dyke, W.J.

    1992-04-07

    A fast valve is disclosed that can close on the order of 7 milliseconds. It is closed by the force of a compressed air spring with the moving parts of the valve designed to be of very light weight and the valve gate being of wedge shaped with O-ring sealed faces to provide sealing contact without metal to metal contact. The combination of the O-ring seal and an air cushion create a soft final movement of the valve closure to prevent the fast air acting valve from having a harsh closing. 4 figs.

  3. Fast valve

    DOEpatents

    Van Dyke, William J.

    1992-01-01

    A fast valve is disclosed that can close on the order of 7 milliseconds. It is closed by the force of a compressed air spring with the moving parts of the valve designed to be of very light weight and the valve gate being of wedge shaped with O-ring sealed faces to provide sealing contact without metal to metal contact. The combination of the O-ring seal and an air cushion create a soft final movement of the valve closure to prevent the fast air acting valve from having a harsh closing.

  4. Fast Crystallization and Improved Stability of Perovskite Solar Cells with Zn2SnO4 Electron Transporting Layer: Interface Matters.

    PubMed

    Bera, Ashok; Sheikh, Arif D; Haque, Md Azimul; Bose, Riya; Alarousu, Erkki; Mohammed, Omar F; Wu, Tom

    2015-12-30

    Here we report that mesoporous ternary oxide Zn2SnO4 can significantly promotes the crystallization of hybrid perovskite layers and serves as an efficient electron transporting material in perovskite solar cells. Such devices exhibit an energy conversion efficiency of 13.34%, which is even higher than that achieved with the commonly used TiO2 in the similar experimental conditions (9.1%). Simple one-step spin coating of CH3NH3PbI3-xClx on Zn2SnO4 is found to lead to rapidly crystallized bilayer perovskite structure without any solvent engineering. Furthermore, ultrafast transient absorption measurement reveals efficient charge transfer at the Zn2SnO4/perovskite interface. Most importantly, solar cells with Zn2SnO4 as the electron-transporting material exhibit negligible electrical hysteresis and exceptionally high stability without encapsulation for over one month. Besides underscoring Zn2SnO4 as a highly promising electron transporting material for perovskite solar cells, our results demonstrate the significant role of interfaces on improving the perovskite crystallization and photovoltaic performance. PMID:26633572

  5. Project FAST.

    ERIC Educational Resources Information Center

    Essexville-Hampton Public Schools, MI.

    Described are components of Project FAST (Functional Analysis Systems Training) a nationally validated project to provide more effective educational and support services to learning disordered children and their regular elementary classroom teachers. The program is seen to be based on a series of modules of delivery systems ranging from mainstream…

  6. Fast ignitor coupling physics

    SciTech Connect

    Mason, R.J.; Tabak, M.

    1997-10-01

    The Fast Ignitor is an alternate approach to ICF in which short pulse lasers are used to initiate burn at the surface of the compressed DT fuel. The aim is to avoid the need for careful central focusing of final shocks, and possibly to lower substantially the energy requirements for ignition. Ultimately, both goals may prove crucial to Science Based Stockpile Stewardship (SBSS). This will be the case should either emerging energetic needs, or funding difficulties render the presently planned radiative fusion approach to ignition with the NIF impractical. Ignition is a first step towards the achievement of substantial energy and neutron outputs for such Stewardship. For success with the Fast Ignitor, the laser energy must be efficiently deposited into megavolt electrons (suprathermal), which must, in turn, couple to the background ions within an alpha particle range. To understand the electron fuel coupling, we have used ANTHEM plasma simulation code to model the transport of hot electrons generated by an intense short pulse laser into plasma targets over a broad range of densities. Our study will spell out the acceleration and transport mechanisms active in the Fast Ignitor environment.

  7. Simulation of Relativistic Electron Transport and Energy Deposition in Fast Ignitor ICF(Inertial Confinement Fusion) using GaPH (a Fluid Element Particle in Cell)

    NASA Astrophysics Data System (ADS)

    Shon, J. W.; Bateson, W. B.; Hewett, D. W.; Tabak, M.; Baldis, H. A.

    1997-11-01

    Ultrahigh intensity lasers can ignite ICF capsules with a total energy of a few tens of kilo joules of laser light, and can possibly lead to high gain with as little as 100 kJ(M. Tabak, J. Hammer, M. E. Glinsky, W. L. Kruer, S. C. Wilks and R. J. Mason, Phys. Plasmas, 1, (1994), 1626.). The energy deposition by relativistic electrons, produced in the high-intensity laser-plasma interactions, is a critical issue for the fuel ignition. A new plasma/fluid transport algorithm called GaPH method(W. B. Bateson and D. W. Hewett, J. Comput. Phys., submitted.) is applied to simulate the propagation of suprathermal electrons and their interactions with background plasma. A field solver using Darwin approximation(D. W. Hewett, J. Comput. Phys., 38, (1980), 378.) provides all components of electromagnetic fields. The initial investigation is focused at hot electron transport to the high density core and the characterization of localized energy deposition. The penetration of energetic electrons depends on the formation of charge-neutralising return current, which is a strong function of the electrical conductivity of the background plasma. *Work performed under the auspices of the U.S. DOE by the LLNL under contract no. W-7405-ENG-48.

  8. Exploiting Resistive Guiding for Fast Ignition

    NASA Astrophysics Data System (ADS)

    Robinson, Alex

    2012-10-01

    Devising methods and schemes for controlling fast electron transport remains a major challenge in Fast Ignition research. Realistic estimates of the fast electron divergence angle require this control in order to ensure that the fast electron to hot spot coupling efficiency does not reach excessively low values. Resistivity gradients in the target will lead to strong magnetic field growth (via ∇ηxj) which can be exploited for the purposes of controlling the fast electron propagation (Robinson and Sherlock, PoP (2007)). There are a number of possible schemes which might be considered. Here we will report on numerical simulations that we have carried out on both simple configurations such as parabolic reflectors, and complex arrangements (Robinson, Key and Tabak, PRL (2012)). Substantial improvements to the fast electron to hot spot coupling efficiency have been found even for realistic fast electron divergence angles.

  9. Fast ignitor coupling physics

    SciTech Connect

    Mason, R.J.; Tabak, M.

    1997-10-01

    The Fast Ignitor is an alternate approach to ICF in which short pulse lasers are used to initiate burn at the surface of the compressed DT fuel. The aim is to avoid the need for careful central focussing of final shocks, and possibly to lower substantially the energy requirements for ignition. Ultimately, both goals may prove crucial to Stockpile Stewardship. For success with the Fast Ignitor, the laser energy must be efficiently deposited into megavolt electrons, which must, in turn, couple to the background ions within an alpha particle range. To understand this coupling, we have used ANTHEM plasma simulation code to model the transport of hot electrons generated by an intense ({ge} 3 x 10{sup 18} W/cm{sup 2}) short pulse 1.06 {mu}m laser into plasma targets over a broad range of densities (0.35 to 10{sup 4} x n{sub crit}). Ponderomotive effects are included as a force on the cold background and hot emission electrons of the form, F{sub h,c} = -({omega}{sup 2}{sub Ph,c}/2{omega}{sup 2}){del}I, in which I is the laser intensity and {omega}{sub p}{sup 2} = 4{pi}e{sup 2}n/m{sub 0}{gamma} with m{sub 0} the electron rest mass.

  10. FAST: FAST Analysis of Sequences Toolbox.

    PubMed

    Lawrence, Travis J; Kauffman, Kyle T; Amrine, Katherine C H; Carper, Dana L; Lee, Raymond S; Becich, Peter J; Canales, Claudia J; Ardell, David H

    2015-01-01

    FAST (FAST Analysis of Sequences Toolbox) provides simple, powerful open source command-line tools to filter, transform, annotate and analyze biological sequence data. Modeled after the GNU (GNU's Not Unix) Textutils such as grep, cut, and tr, FAST tools such as fasgrep, fascut, and fastr make it easy to rapidly prototype expressive bioinformatic workflows in a compact and generic command vocabulary. Compact combinatorial encoding of data workflows with FAST commands can simplify the documentation and reproducibility of bioinformatic protocols, supporting better transparency in biological data science. Interface self-consistency and conformity with conventions of GNU, Matlab, Perl, BioPerl, R, and GenBank help make FAST easy and rewarding to learn. FAST automates numerical, taxonomic, and text-based sorting, selection and transformation of sequence records and alignment sites based on content, index ranges, descriptive tags, annotated features, and in-line calculated analytics, including composition and codon usage. Automated content- and feature-based extraction of sites and support for molecular population genetic statistics make FAST useful for molecular evolutionary analysis. FAST is portable, easy to install and secure thanks to the relative maturity of its Perl and BioPerl foundations, with stable releases posted to CPAN. Development as well as a publicly accessible Cookbook and Wiki are available on the FAST GitHub repository at https://github.com/tlawrence3/FAST. The default data exchange format in FAST is Multi-FastA (specifically, a restriction of BioPerl FastA format). Sanger and Illumina 1.8+ FastQ formatted files are also supported. FAST makes it easier for non-programmer biologists to interactively investigate and control biological data at the speed of thought. PMID:26042145

  11. FAST: FAST Analysis of Sequences Toolbox

    PubMed Central

    Lawrence, Travis J.; Kauffman, Kyle T.; Amrine, Katherine C. H.; Carper, Dana L.; Lee, Raymond S.; Becich, Peter J.; Canales, Claudia J.; Ardell, David H.

    2015-01-01

    FAST (FAST Analysis of Sequences Toolbox) provides simple, powerful open source command-line tools to filter, transform, annotate and analyze biological sequence data. Modeled after the GNU (GNU's Not Unix) Textutils such as grep, cut, and tr, FAST tools such as fasgrep, fascut, and fastr make it easy to rapidly prototype expressive bioinformatic workflows in a compact and generic command vocabulary. Compact combinatorial encoding of data workflows with FAST commands can simplify the documentation and reproducibility of bioinformatic protocols, supporting better transparency in biological data science. Interface self-consistency and conformity with conventions of GNU, Matlab, Perl, BioPerl, R, and GenBank help make FAST easy and rewarding to learn. FAST automates numerical, taxonomic, and text-based sorting, selection and transformation of sequence records and alignment sites based on content, index ranges, descriptive tags, annotated features, and in-line calculated analytics, including composition and codon usage. Automated content- and feature-based extraction of sites and support for molecular population genetic statistics make FAST useful for molecular evolutionary analysis. FAST is portable, easy to install and secure thanks to the relative maturity of its Perl and BioPerl foundations, with stable releases posted to CPAN. Development as well as a publicly accessible Cookbook and Wiki are available on the FAST GitHub repository at https://github.com/tlawrence3/FAST. The default data exchange format in FAST is Multi-FastA (specifically, a restriction of BioPerl FastA format). Sanger and Illumina 1.8+ FastQ formatted files are also supported. FAST makes it easier for non-programmer biologists to interactively investigate and control biological data at the speed of thought. PMID:26042145

  12. Enhanced Model for Fast Ignition

    SciTech Connect

    Mason, Rodney J.

    2010-10-12

    Laser Fusion is a prime candidate for alternate energy production, capable of serving a major portion of the nation's energy needs, once fusion fuel can be readily ignited. Fast Ignition may well speed achievement of this goal, by reducing net demands on laser pulse energy and timing precision. However, Fast Ignition has presented a major challenge to modeling. This project has enhanced the computer code ePLAS for the simulation of the many specialized phenomena, which arise with Fast Ignition. The improved code has helped researchers to understand better the consequences of laser absorption, energy transport, and laser target hydrodynamics. ePLAS uses efficient implicit methods to acquire solutions for the electromagnetic fields that govern the accelerations of electrons and ions in targets. In many cases, the code implements fluid modeling for these components. These combined features, "implicitness and fluid modeling," can greatly facilitate calculations, permitting the rapid scoping and evaluation of experiments. ePLAS can be used on PCs, Macs and Linux machines, providing researchers and students with rapid results. This project has improved the treatment of electromagnetics, hydrodynamics, and atomic physics in the code. It has simplified output graphics, and provided new input that avoids the need for source code access by users. The improved code can now aid university, business and national laboratory users in pursuit of an early path to success with Fast Ignition.

  13. Catalytic fast pyrolysis of lignocellulosic biomass.

    PubMed

    Liu, Changjun; Wang, Huamin; Karim, Ayman M; Sun, Junming; Wang, Yong

    2014-11-21

    Increasing energy demand, especially in the transportation sector, and soaring CO2 emissions necessitate the exploitation of renewable sources of energy. Despite the large variety of new energy carriers, liquid hydrocarbon still appears to be the most attractive and feasible form of transportation fuel taking into account the energy density, stability and existing infrastructure. Biomass is an abundant, renewable source of energy; however, utilizing it in a cost-effective way is still a substantial challenge. Lignocellulose is composed of three major biopolymers, namely cellulose, hemicellulose and lignin. Fast pyrolysis of biomass is recognized as an efficient and feasible process to selectively convert lignocellulose into a liquid fuel-bio-oil. However bio-oil from fast pyrolysis contains a large amount of oxygen, distributed in hundreds of oxygenates. These oxygenates are the cause of many negative properties, such as low heating value, high corrosiveness, high viscosity, and instability; they also greatly limit the application of bio-oil particularly as transportation fuel. Hydrocarbons derived from biomass are most attractive because of their high energy density and compatibility with the existing infrastructure. Thus, converting lignocellulose into transportation fuels via catalytic fast pyrolysis has attracted much attention. Many studies related to catalytic fast pyrolysis of biomass have been published. The main challenge of this process is the development of active and stable catalysts that can deal with a large variety of decomposition intermediates from lignocellulose. This review starts with the current understanding of the chemistry in fast pyrolysis of lignocellulose and focuses on the development of catalysts in catalytic fast pyrolysis. Recent progress in the experimental studies on catalytic fast pyrolysis of biomass is also summarized with the emphasis on bio-oil yields and quality. PMID:24801125

  14. Catalytic fast pyrolysis of lignocellulosic biomass

    SciTech Connect

    Liu, Changjun; Wang, Huamin; Karim, Ayman M.; Sun, Junming; Wang, Yong

    2014-11-21

    Increasing energy demand, especially in the transportation sector, and soaring CO2 emissions necessitate the exploitation of renewable sources of energy. Despite the large variety of new energy Q3 carriers, liquid hydrocarbon still appears to be the most attractive and feasible form of transportation fuel taking into account the energy density, stability and existing infrastructure. Biomass is an abundant, renewable source of energy; however, utilizing it in a cost-effective way is still a substantial challenge. Lignocellulose is composed of three major biopolymers, namely cellulose, hemicellulose and lignin. Fast pyrolysis of biomass is recognized as an efficient and feasible process to selectively convert lignocellulose into a liquid fuel—bio-oil. However bio-oil from fast pyrolysis contains a large amount of oxygen, distributed in hundreds of oxygenates. These oxygenates are the cause of many negative properties, such as low heating values, high corrosiveness, high viscosity, and instability; they also greatly Q4 limit the application of bio-oil particularly as transportation fuel. Hydrocarbons derived from biomass are most attractive because of their high energy density and compatibility with the existing infrastructure. Thus, converting lignocellulose into transportation fuels via catalytic fast pyrolysis has attracted much attention. Many studies related to catalytic fast pyrolysis of biomass have been published. The main challenge of this process is the development of active and stable catalysts that can deal with a large variety of decomposition intermediates from lignocellulose. This review starts with the current understanding of the chemistry in fast pyrolysis of lignocellulose and focuses on the development of catalysts in catalytic fast pyrolysis. Recent progress in the experimental studies on catalytic fast pyrolysis of biomass is also summarized with the emphasis on bio-oil yields and quality.

  15. Fast food (image)

    MedlinePlus

    Fast foods are quick, reasonably priced, and readily available alternatives to home cooking. While convenient and economical for a busy lifestyle, fast foods are typically high in calories, fat, saturated fat, ...

  16. Fast food tips (image)

    MedlinePlus

    ... challenge to eat healthy when going to a fast food place. In general, avoiding items that are deep ... challenge to eat healthy when going to a fast food place. In general, avoiding items that are deep ...

  17. Acid-fast stain

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/003766.htm Acid-fast stain To use the sharing features on this page, please enable JavaScript. The acid-fast stain is a laboratory test that determines ...

  18. Is fast food addictive?

    PubMed

    Garber, Andrea K; Lustig, Robert H

    2011-09-01

    Studies of food addiction have focused on highly palatable foods. While fast food falls squarely into that category, it has several other attributes that may increase its salience. This review examines whether the nutrients present in fast food, the characteristics of fast food consumers or the presentation and packaging of fast food may encourage substance dependence, as defined by the American Psychiatric Association. The majority of fast food meals are accompanied by a soda, which increases the sugar content 10-fold. Sugar addiction, including tolerance and withdrawal, has been demonstrated in rodents but not humans. Caffeine is a "model" substance of dependence; coffee drinks are driving the recent increase in fast food sales. Limited evidence suggests that the high fat and salt content of fast food may increase addictive potential. Fast food restaurants cluster in poorer neighborhoods and obese adults eat more fast food than those who are normal weight. Obesity is characterized by resistance to insulin, leptin and other hormonal signals that would normally control appetite and limit reward. Neuroimaging studies in obese subjects provide evidence of altered reward and tolerance. Once obese, many individuals meet criteria for psychological dependence. Stress and dieting may sensitize an individual to reward. Finally, fast food advertisements, restaurants and menus all provide environmental cues that may trigger addictive overeating. While the concept of fast food addiction remains to be proven, these findings support the role of fast food as a potentially addictive substance that is most likely to create dependence in vulnerable populations. PMID:21999689

  19. Fast-Food Environments and Family Fast-Food Intake in Nonmetropolitan Areas

    PubMed Central

    Longacre, Meghan R.; Drake, Keith M.; MacKenzie, Todd A.; Gibson, Lucinda; Owens, Peter; Titus, Linda J.; Beach, Michael L.; Dalton, Madeline A.

    2012-01-01

    Background Little is known about the influence of in-town fast-food availability on family-level fast-food intake in nonmetropolitan areas. Purpose The purpose of the current study was to determine whether the presence of chain fast-food outlets was associated with fast-food intake among adolescents and parents, and to assess whether this relationship was moderated by family access to motor vehicles. Methods Telephone surveys were conducted with 1547 adolescent–parent dyads in 32 New Hampshire and Vermont communities between 2007 and 2008. Fast-food intake in the past week was measured through self-report. In-town fast-food outlets were located and enumerated using an onsite audit. Family motor vehicle access was categorized based on the number of vehicles per licensed drivers in the household. Poisson regression was used to determine unadjusted and adjusted risk ratios (RRs). Analyses were conducted in 2011. Results About half (52.1%) of adolescents and 34.7% of parents consumed fast food at least once in the past week. Adolescents and parents who lived in towns with five or more fast-food outlets were about 30% more likely to eat fast food compared to those in towns with no fast-food outlets, even after adjusting for individual, family, and town characteristics (RR=1.29, 95% CI= 1.10, 1.51; RR=1.32, 95% CI=1.07,1.62, respectively). Interaction models demonstrated that the influence of in-town fast-food outlets on fast-food intake was strongest among families with low motor vehicle access. Conclusions In nonmetropolitan areas, household transportation should be considered as an important moderator of the relationship between in-town fast-food outlets and family intake. PMID:22608373

  20. FAST User Guide

    NASA Technical Reports Server (NTRS)

    Walatka, Pamela P.; Clucas, Jean; McCabe, R. Kevin; Plessel, Todd; Potter, R.; Cooper, D. M. (Technical Monitor)

    1994-01-01

    The Flow Analysis Software Toolkit, FAST, is a software environment for visualizing data. FAST is a collection of separate programs (modules) that run simultaneously and allow the user to examine the results of numerical and experimental simulations. The user can load data files, perform calculations on the data, visualize the results of these calculations, construct scenes of 3D graphical objects, and plot, animate and record the scenes. Computational Fluid Dynamics (CFD) visualization is the primary intended use of FAST, but FAST can also assist in the analysis of other types of data. FAST combines the capabilities of such programs as PLOT3D, RIP, SURF, and GAS into one environment with modules that share data. Sharing data between modules eliminates the drudgery of transferring data between programs. All the modules in the FAST environment have a consistent, highly interactive graphical user interface. Most commands are entered by pointing and'clicking. The modular construction of FAST makes it flexible and extensible. The environment can be custom configured and new modules can be developed and added as needed. The following modules have been developed for FAST: VIEWER, FILE IO, CALCULATOR, SURFER, TOPOLOGY, PLOTTER, TITLER, TRACER, ARCGRAPH, GQ, SURFERU, SHOTET, and ISOLEVU. A utility is also included to make the inclusion of user defined modules in the FAST environment easy. The VIEWER module is the central control for the FAST environment. From VIEWER, the user can-change object attributes, interactively position objects in three-dimensional space, define and save scenes, create animations, spawn new FAST modules, add additional view windows, and save and execute command scripts. The FAST User Guide uses text and FAST MAPS (graphical representations of the entire user interface) to guide the user through the use of FAST. Chapters include: Maps, Overview, Tips, Getting Started Tutorial, a separate chapter for each module, file formats, and system

  1. Measuring Fast Ion Losses in a Reversed Field Pinch Plasma

    NASA Astrophysics Data System (ADS)

    Bonofiglo, P. J.; Anderson, J. K.; Almagri, A. F.; Kim, J.; Clark, J.; Capecchi, W.; Sears, S. H.

    2015-11-01

    The reversed field pinch (RFP) provides a unique environment to study fast ion confinement and transport. The RFP's weak toroidal field, strong magnetic shear, and ability to enter a 3D state provide a wide range of dynamics to study fast ions. Core-localized, 25 keV fast ions are sourced into MST by a tangentially injected hydrogen/deuterium neutral beam. Neutral particle analysis and measured fusion neutron flux indicate enhanced fast ion transport in the plasma core. Past experiments point to a dynamic loss of fast ions associated with the RFP's transition to a 3D state and with beam-driven, bursting magnetic modes. Consequently, fast ion transport and losses in the RFP have garnered recent attention. Valuable information on fast-ion loss, such as energy and pitch distributions, are sought to provide a better understanding of the transport mechanisms at hand. We have constructed and implemented two fast ion loss detectors (FILDs) for use on MST. The FILDs have two, independent, design concepts: collecting particles as a function of v⊥ or with pitch greater than 0.8. In this work, we present our preliminary findings and results from our FILDs on MST. This research is supported by US DOE.

  2. Fast Ion Redistribution and Implications for the Hybrid Regime

    SciTech Connect

    Nazikian, R; Austin, M E; Budny, R V; Chu, M S; Heidbrink, W W; Makowski, M A; Petty, C C; Politzer, P A; Solomon, W M; Van Zeeland, M A

    2007-06-26

    Time dependent TRANSP analysis indicates that radial redistribution of fast ions is unlikely to affect the central current density in hybrid plasmas sufficient to raise q(0) above unity. The results suggest that some other mechanism other than fast ion transport must be involved in raising q(0) and preventing sawteeth in hybrid plasmas.

  3. Diagnostics for Fast Ignition Science

    SciTech Connect

    MacPhee, A; Akli, K; Beg, F; Chen, C; Chen, H; Clarke, R; Hey, D; Freeman, R; Kemp, A; Key, M; King, J; LePape, S; Link, A; Ma, T; Nakamura, N; Offermann, D; Ovchinnikov, V; Patel, P; Phillips, T; Stephens, R; Town, R; Wei, M; VanWoerkom, L; Mackinnon, A

    2008-05-06

    The concept for Electron Fast Ignition Inertial Confinement Fusion demands sufficient laser energy be transferred from the ignitor pulse to the assembled fuel core via {approx}MeV electrons. We have assembled a suite of diagnostics to characterize such transfer. Recent experiments have simultaneously fielded absolutely calibrated extreme ultraviolet multilayer imagers at 68 and 256eV; spherically bent crystal imagers at 4 and 8keV; multi-keV crystal spectrometers; MeV x-ray bremmstrahlung and electron and proton spectrometers (along the same line of sight); nuclear activation samples and a picosecond optical probe based interferometer. These diagnostics allow careful measurement of energy transport and deposition during and following laser-plasma interactions at extremely high intensities in both planar and conical targets. Augmented with accurate on-shot laser focal spot and pre-pulse characterization, these measurements are yielding new insight into energy coupling and are providing critical data for validating numerical PIC and hybrid PIC simulation codes in an area that is crucial for many applications, particularly fast ignition. Novel aspects of these diagnostics and how they are combined to extract quantitative data on ultra high intensity laser plasma interactions are discussed, together with implications for full-scale fast ignition experiments.

  4. Fast food (image)

    MedlinePlus

    ... quick, reasonably priced, and readily available alternatives to home cooking. While convenient and economical for a busy lifestyle, fast foods are typically high in calories, fat, saturated fat, ...

  5. fast-matmul

    SciTech Connect

    Grey Ballard, Austin Benson

    2014-11-26

    This software provides implementations of fast matrix multiplication algorithms. These algorithms perform fewer floating point operations than the classical cubic algorithm. The software uses code generation to automatically implement the fast algorithms based on high-level descriptions. The code serves two general purposes. The first is to demonstrate that these fast algorithms can out-perform vendor matrix multiplication algorithms for modest problem sizes on a single machine. The second is to rapidly prototype many variations of fast matrix multiplication algorithms to encourage future research in this area. The implementations target sequential and shared memory parallel execution.

  6. [Medical aspects of fasting].

    PubMed

    Gavrankapetanović, F

    1997-01-01

    Fasting (arabic-savm) was proclaimed through islam, and thus it is an obligation for Holly Prophet Muhammad s.a.v.s.-Peace be to Him-in the second year after Hijra (in 624 after Milad-born of Isa a.s.). There is a month of fasting-Ramadan-each lunar (hijra) year. So, it was 1415th fasting this year. Former Prophets have brought obligative messages on fasting to their people; so there are also certain forms of fasting with other religions i.e. with Catholics, Jews, Orthodox. These kinds of fasting above differ from muslim fasting, but they also appear obligative. All revelations have brought fasting as obligative. From medical point of view, fasting has two basical components: psychical and physical. Psychical sphere correlate closely with its fundamental ideological message. Allah dz.s. says in Quran: "... Fasting is obligative for you, as it was obligative to your precedents, as to avoid sins; during very few days (II, II, 183 & 184)." Will strength, control of passions, effort and self-discipline makes a pure faithfull person, who purify its mind and body through fasting. Thinking about The Creator is more intensive, character is more solid; and spirit and will get stronger. We will mention the hadith saying: "Essaihune humus saimun!" That means: "Travellers at the Earth are fasters (of my ummet)." The commentary of this hadith, in the Collection of 1001 hadiths (Bin bir hadis), number 485, says: "There are no travelling dervishs or monks in islam; thus there is no such a kind of relligousity in islam. In stead, it is changed by fasting and constant attending of mosque. That was proclaimed as obligation, although there were few cases of travelling in the name of relligousity, like travelling dervishs and sheichs." In this paper, the author discusses medical aspects of fasting and its positive characteristics in the respect of healthy life style and prevention of many sicks. The author mentions positive influence of fasting to certain system and organs of human

  7. Integrative Physiology of Fasting.

    PubMed

    Secor, Stephen M; Carey, Hannah V

    2016-04-01

    Extended bouts of fasting are ingrained in the ecology of many organisms, characterizing aspects of reproduction, development, hibernation, estivation, migration, and infrequent feeding habits. The challenge of long fasting episodes is the need to maintain physiological homeostasis while relying solely on endogenous resources. To meet that challenge, animals utilize an integrated repertoire of behavioral, physiological, and biochemical responses that reduce metabolic rates, maintain tissue structure and function, and thus enhance survival. We have synthesized in this review the integrative physiological, morphological, and biochemical responses, and their stages, that characterize natural fasting bouts. Underlying the capacity to survive extended fasts are behaviors and mechanisms that reduce metabolic expenditure and shift the dependency to lipid utilization. Hormonal regulation and immune capacity are altered by fasting; hormones that trigger digestion, elevate metabolism, and support immune performance become depressed, whereas hormones that enhance the utilization of endogenous substrates are elevated. The negative energy budget that accompanies fasting leads to the loss of body mass as fat stores are depleted and tissues undergo atrophy (i.e., loss of mass). Absolute rates of body mass loss scale allometrically among vertebrates. Tissues and organs vary in the degree of atrophy and downregulation of function, depending on the degree to which they are used during the fast. Fasting affects the population dynamics and activities of the gut microbiota, an interplay that impacts the host's fasting biology. Fasting-induced gene expression programs underlie the broad spectrum of integrated physiological mechanisms responsible for an animal's ability to survive long episodes of natural fasting. PMID:27065168

  8. Fast protein folding kinetics

    PubMed Central

    Gelman, Hannah; Gruebele, Martin

    2014-01-01

    Fast folding proteins have been a major focus of computational and experimental study because they are accessible to both techniques: they are small and fast enough to be reasonably simulated with current computational power, but have dynamics slow enough to be observed with specially developed experimental techniques. This coupled study of fast folding proteins has provided insight into the mechanisms which allow some proteins to find their native conformation well less than 1 ms and has uncovered examples of theoretically predicted phenomena such as downhill folding. The study of fast folders also informs our understanding of even “slow” folding processes: fast folders are small, relatively simple protein domains and the principles that govern their folding also govern the folding of more complex systems. This review summarizes the major theoretical and experimental techniques used to study fast folding proteins and provides an overview of the major findings of fast folding research. Finally, we examine the themes that have emerged from studying fast folders and briefly summarize their application to protein folding in general as well as some work that is left to do. PMID:24641816

  9. fastKDE

    SciTech Connect

    O'Brien, Travis A.; Kashinath, Karthik

    2015-05-22

    This software implements the fast, self-consistent probability density estimation described by O'Brien et al. (2014, doi: ). It uses a non-uniform fast Fourier transform technique to reduce the computational cost of an objective and self-consistent kernel density estimation method.

  10. Fast and effective?

    PubMed

    Trueland, Jennifer

    2013-12-18

    The 5.2 diet involves two days of fasting each week. It is being promoted as the key to sustained weight loss, as well as wider health benefits, despite the lack of evidence on the long-term effects. Nurses need to support patients who wish to try intermittent fasting. PMID:24345130

  11. RFI Mitigation for FAST

    NASA Astrophysics Data System (ADS)

    Zhang, Haiyan; Nan, Rendong; Gan, Hengqian; Yue, Youling; Wu, Mingchang; Zhang, Zhiwei; Jin, Chengjin; Peng, Bo

    2015-08-01

    Five-hundred-meter Aperture Spherical radio Telescope (FAST) is a Chinese mega-science project to build the largest single dish radio telescope in the world. The construction was officially commenced in March 2011. The first light of FAST is expected in 2016. Due to the high sensitivity of FAST, Radio Frequency Interference (RFI) mitigation for the telescope is required to assure the realization of the scientific goals. In order to protect the radio environment of FAST site, the local government has established a radio quiet zone with 30 km radius. Moreover, Electromagnetic Compatibility (EMC) designs and measurements for FAST have also been carried out, and some examples, such as EMC designs for actuator and focus cabin, have been introduced briefly.

  12. Dual fluidized bed design for the fast pyrolysis of biomass

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A mechanism for the transport of solids between fluidised beds in dual fluidised bed systems for the fast pyrolysis of biomass process was selected. This mechanism makes use of an overflow standpipe to transport solids from the fluidised bed used for the combustion reactions to a second fluidised be...

  13. A Code to Produce Cell Averaged Cross Sections for Fast Critical Assemblies and Fast Power Reactors.

    Energy Science and Technology Software Center (ESTSC)

    1987-05-14

    Version 00 SLAROM solves the neutron integral transport equations to determine the flux distribution and spectra in a fast reactor lattice and calculates cell averaged effective cross sections. The code uses multigroup data of the type in DLC-111/JFS that use Bondarenko factors for resonance effects.

  14. Reusable fast opening switch

    DOEpatents

    Van Devender, J.P.; Emin, D.

    1983-12-21

    A reusable fast opening switch for transferring energy, in the form of a high power pulse, from an electromagnetic storage device such as an inductor into a load. The switch is efficient, compact, fast and reusable. The switch comprises a ferromagnetic semiconductor which undergoes a fast transition between conductive and metallic states at a critical temperature and which undergoes the transition without a phase change in its crystal structure. A semiconductor such as europium rich europhous oxide, which undergoes a conductor to insulator transition when it is joule heated from its conductor state, can be used to form the switch.

  15. Fast Breeder Reactor studies

    SciTech Connect

    Till, C.E.; Chang, Y.I.; Kittel, J.H.; Fauske, H.K.; Lineberry, M.J.; Stevenson, M.G.; Amundson, P.I.; Dance, K.D.

    1980-07-01

    This report is a compilation of Fast Breeder Reactor (FBR) resource documents prepared to provide the technical basis for the US contribution to the International Nuclear Fuel Cycle Evaluation. The eight separate parts deal with the alternative fast breeder reactor fuel cycles in terms of energy demand, resource base, technical potential and current status, safety, proliferation resistance, deployment, and nuclear safeguards. An Annex compares the cost of decommissioning light-water and fast breeder reactors. Separate abstracts are included for each of the parts.

  16. Fasting and cognitive function.

    PubMed

    Pollitt, E; Lewis, N L; Garza, C; Shulman, R J

    The effects of short-term fasting (skipping breakfast) on the problem-solving performance of 9 to 11 yr old children were studied under the controlled conditions of a metabolic ward. The behavioral test battery included an assessment of IQ, the Matching Familiar Figure Test and Hagen Central Incidental Test. Glucose and insulin levels were measured in blood. All assessments were made under fasting and non-fasting conditions. Skipping breakfast was found to have adverse effects on the children's late morning problem-solving performance. These findings support observations that the timing and nutrient composition of meals have acute and demonstrable effects on behavior. PMID:6764933

  17. fast-matmul

    Energy Science and Technology Software Center (ESTSC)

    2014-11-26

    This software provides implementations of fast matrix multiplication algorithms. These algorithms perform fewer floating point operations than the classical cubic algorithm. The software uses code generation to automatically implement the fast algorithms based on high-level descriptions. The code serves two general purposes. The first is to demonstrate that these fast algorithms can out-perform vendor matrix multiplication algorithms for modest problem sizes on a single machine. The second is to rapidly prototype many variations of fastmore » matrix multiplication algorithms to encourage future research in this area. The implementations target sequential and shared memory parallel execution.« less

  18. Fast-ion Dα measurements of the fast-ion distribution (invited).

    PubMed

    Heidbrink, W W

    2010-10-01

    The fast-ion Dα (FIDA) diagnostic is an application of charge-exchange recombination spectroscopy. Fast ions that neutralize in an injected neutral beam emit Balmer-α light with a large Doppler shift. The spectral shift is exploited to distinguish the FIDA emission from other bright sources of Dα light. Background subtraction is the main technical challenge. A spectroscopic diagnostic typically achieves temporal, energy, and transverse spatial resolution of ∼1 ms, ∼10 keV, and ∼2 cm, respectively. Installations that use narrow-band filters achieve high spatial and temporal resolution at the expense of spectral information. For high temporal resolution, the bandpass-filtered light goes directly to a photomultiplier, allowing detection of ∼50 kHz oscillations in FIDA signal. For two-dimensional spatial profiles, the bandpass-filtered light goes to a charge-coupled device camera; detailed images of fast-ion redistribution at instabilities are obtained. Qualitative and quantitative models relate the measured FIDA signals to the fast-ion distribution function. The first quantitative comparisons between theory and experiment found excellent agreement in beam-heated magnetohydrodynamics (MHD)-quiescent plasmas. FIDA diagnostics are now in operation at magnetic-fusion facilities worldwide. They are used to study fast-ion acceleration by ion cyclotron heating, to detect fast-ion transport by MHD modes and microturbulence, and to study fast-ion driven instabilities. PMID:21033920

  19. Acid-fast stain

    MedlinePlus

    The acid-fast stain is a laboratory test that determines if a sample of tissue, blood, or other body ... dye. The slide is then washed with an acid solution and a different stain is applied. Bacteria ...

  20. Discovery with FAST

    NASA Astrophysics Data System (ADS)

    Wilkinson, P.

    2016-02-01

    FAST offers "transformational" performance well-suited to finding new phenomena - one of which might be polarised spectral transients. But discoveries will only be made if "the system" provides its users with the necessary opportunities. In addition to designing in as much observational flexibility as possible, FAST should be operated with a philosophy which maximises its "human bandwidth". This band includes the astronomers of tomorrow - many of whom not have yet started school or even been born.

  1. Explicit lower bounds for the cost of fast controls for some 1-D parabolic or dispersive equations, and a new lower bound concerning the uniform controllability of the 1-D transport-diffusion equation

    NASA Astrophysics Data System (ADS)

    Lissy, Pierre

    2015-11-01

    In this paper, we prove explicit lower bounds for the cost of fast boundary controls for a class of linear equations of parabolic or dispersive type involving the spectral fractional Laplace operator. We notably deduce the following striking result: in the case of the heat equation controlled on the boundary, Miller's conjecture formulated in Miller (2004) [16] is not verified. Moreover, we also give a new lower bound for the minimal time needed to ensure the uniform controllability of the one-dimensional convection-diffusion equation with negative speed controlled on the left boundary, proving that the conjecture formulated in Coron and Guerrero (2005) [2] concerning this problem is also not verified at least for negative speeds. The proof is based on complex analysis, and more precisely on a representation formula for entire functions of exponential type, and is quite related to the moment method.

  2. FAST2 Code validation

    SciTech Connect

    Wilson, R.E.; Freeman, L.N.; Walker, S.N.

    1995-09-01

    The FAST2 Code which is capable of determining structural loads of a flexible, teetering, horizontal axis wind turbine is described and comparisons of calculated loads with test data at two wind speeds for the ESI-80 are given. The FAST2 Code models a two-bladed HAWT with degrees of freedom for blade flap, teeter, drive train flexibility, yaw, and windwise and crosswind tower motion. The code allows blade dimensions, stiffness, and weights to differ and models tower shadow, wind shear, and turbulence. Additionally, dynamic stall is included as are delta-3 and an underslung rotor. Load comparisons are made with ESI-80 test data in the form of power spectral density, rainflow counting, occurrence histograms and azimuth averaged bin plots. It is concluded that agreement between the FAST2 Code and test results is good.

  3. Fast Reactor Technology Preservation

    SciTech Connect

    Wootan, David W.; Omberg, Ronald P.

    2008-01-11

    There is renewed worldwide interest in developing and implementing a new generation of advanced fast reactors. International cooperative efforts are underway such as the Global Nuclear Energy Partnership (GNEP). Advanced computer modeling and simulation efforts are a key part of these programs. A recognized and validated set of Benchmark Cases are an essential component of such modeling efforts. Testing documentation developed during the operation of the Fast Flux Test Facility (FFTF) provide the information necessary to develop a very useful set of Benchmark Cases.

  4. Integral Fast Reactor concept

    SciTech Connect

    Till, C.E.; Chang, Y.I.

    1986-01-01

    The Integral Fast Reactor (IFR) is an innovative LMR concept, being developed at Argonne National Laboratory, that fully exploits the inherent properties of liquid metal cooling and metallic fuel to achieve breakthroughs in economics and inherent safety. This paper describes key features and potential advantages of the IFR concept, technology development status, fuel cycle economics potential, and future development path.

  5. The Integral Fast Reactor

    SciTech Connect

    Till, C.E.; Chang, Y.I. ); Lineberry, M.J. )

    1990-01-01

    Argonne National Laboratory, since 1984, has been developing the Integral Fast Reactor (IFR). This paper will describe the way in which this new reactor concept came about; the technical, public acceptance, and environmental issues that are addressed by the IFR; the technical progress that has been made; and our expectations for this program in the near term. 5 refs., 3 figs.

  6. FAST - FREEDOM ASSEMBLY SEQUENCING TOOL PROTOTYPE

    NASA Technical Reports Server (NTRS)

    Borden, C. S.

    1994-01-01

    FAST is a project management tool designed to optimize the assembly sequence of Space Station Freedom. An appropriate assembly sequence coordinates engineering, design, utilization, transportation availability, and operations requirements. Since complex designs tend to change frequently, FAST assesses the system level effects of detailed changes and produces output metrics that identify preferred assembly sequences. FAST incorporates Space Shuttle integration, Space Station hardware, on-orbit operations, and programmatic drivers as either precedence relations or numerical data. Hardware sequencing information can either be input directly and evaluated via the "specified" mode of operation or evaluated from the input precedence relations in the "flexible" mode. In the specified mode, FAST takes as its input a list of the cargo elements assigned to each flight. The program determines positions for the cargo elements that maximize the center of gravity (c.g.) margin. These positions are restricted by the geometry of the cargo elements and the location of attachment fittings both in the orbiter and on the cargo elements. FAST calculates every permutation of cargo element location according to its height, trunnion fitting locations, and required intercargo element spacing. Each cargo element is tested in both its normal and reversed orientation (rotated 180 degrees). The best solution is that which maximizes the c.g. margin for each flight. In the flexible mode, FAST begins with the first flight and determines all feasible combinations of cargo elements according to mass, volume, EVA, and precedence relation constraints. The program generates an assembly sequence that meets mass, volume, position, EVA, and precedence constraints while minimizing the total number of Shuttle flights required. Issues associated with ground operations, spacecraft performance, logistics requirements and user requirements will be addressed in future versions of the model. FAST is written in C

  7. Radiation Transport

    SciTech Connect

    Urbatsch, Todd James

    2015-06-15

    We present an overview of radiation transport, covering terminology, blackbody raditation, opacities, Boltzmann transport theory, approximations to the transport equation. Next we introduce several transport methods. We present a section on Caseology, observing transport boundary layers. We briefly broach topics of software development, including verification and validation, and we close with a section on high energy-density experiments that highlight and support radiation transport.

  8. Magnetically guided fast electrons in cylindrically compressed matter.

    PubMed

    Pérez, F; Debayle, A; Honrubia, J; Koenig, M; Batani, D; Baton, S D; Beg, F N; Benedetti, C; Brambrink, E; Chawla, S; Dorchies, F; Fourment, C; Galimberti, M; Gizzi, L A; Gremillet, L; Heathcote, R; Higginson, D P; Hulin, S; Jafer, R; Koester, P; Labate, L; Lancaster, K L; MacKinnon, A J; MacPhee, A G; Nazarov, W; Nicolai, P; Pasley, J; Ramis, R; Richetta, M; Santos, J J; Sgattoni, A; Spindloe, C; Vauzour, B; Vinci, T; Volpe, L

    2011-08-01

    Fast electrons produced by a 10 ps, 160 J laser pulse through laser-compressed plastic cylinders are studied experimentally and numerically in the context of fast ignition. K(α)-emission images reveal a collimated or scattered electron beam depending on the initial density and the compression timing. A numerical transport model shows that implosion-driven electrical resistivity gradients induce strong magnetic fields able to guide the electrons. The good agreement with measured beam sizes provides the first experimental evidence for fast-electron magnetic collimation in laser-compressed matter. PMID:21902333

  9. "Fast" Capitalism and "Fast" Schools: New Realities and New Truths.

    ERIC Educational Resources Information Center

    Robertson, Susan L.

    This paper locates the phenomenon of self-managing schools within the framework of "fast capitalism" and identifies themes of organization central to fast capitalism, which are argued to also underpin the self-managing schools. "Fast capitalism" refers to the rapidly intensified integration of regionalized productive activities into the global…

  10. Fast electrochemical actuator

    NASA Astrophysics Data System (ADS)

    Uvarov, I. V.; Postnikov, A. V.; Svetovoy, V. B.

    2016-03-01

    Lack of fast and strong microactuators is a well-recognized problem in MEMS community. Electrochemical actuators can develop high pressure but they are notoriously slow. Water electrolysis produced by short voltage pulses of alternating polarity can overcome the problem of slow gas termination. Here we demonstrate an actuation regime, for which the gas pressure is relaxed just for 10 μs or so. The actuator consists of a microchamber filled with the electrolyte and covered with a flexible membrane. The membrane bends outward when the pressure in the chamber increases. Fast termination of gas and high pressure developed in the chamber are related to a high density of nanobubbles in the chamber. The physical processes happening in the chamber are discussed so as problems that have to be resolved for practical applications of this actuation regime. The actuator can be used as a driving engine for microfluidics.

  11. Fast fission phenomenon

    NASA Astrophysics Data System (ADS)

    In these lectures we have described two different phenomena occuring in dissipative heavy ion collisions : neutron-proton asymmetry and fast fission. Neutron-proton asymmetry has provided us with an example of a fast collective motion. As a consequence quantum fluctuations can be observed. The observation of quantum or statistical fluctuations is directly connected to the comparison between the phonon energy and the temperature of the intrinsic system. This means that this mode might also provide a good example for the investigation of the transition between quantum and statistical fluctuations which might occur when the bombarding energy is raised above 10 MeV/A. However it is by no means sure that in this energy domain enough excitation energy can be put into the system in order to reach such high temperatures over the all system. The other interest in investigating neutron-proton asymmetry above 10 MeV/A is that the interaction time between the two incident nuclei will decrease. Consequently, if some collective motion should still be observed, it will be one of the last which can be seen. Fast fission corresponds on the contrary to long interaction times. The experimental indications are still rather weak and mainly consist of experimental data which cannot be understood in the framework of standard dissipative models. We have seen that a model which can describe both the entrance and the exit configuration gives this mechanism in a natural way and that the experimental data can, to a good extend, be explained. The nicest thing is probably that our old understanding of dissipative heavy ion collisions is not changed at all except for the problems that can now be understood in terms of fast fission. Nevertheless this area desserve further studies, especially on the experimental side to be sure that the consistent picture which we have on dissipative heavy ion collisions still remain coherent in the future.

  12. Fast tracking hospital construction.

    PubMed

    Quirk, Andrew

    2013-03-01

    Hospital leaders should consider four factors in determining whether to fast track a hospital construction project: Expectations of project length, quality, and cost. Whether decisions can be made quickly as issues arise. Their own time commitment to the project, as well as that of architects, engineers, construction managers, and others. The extent to which they are willing to share with the design and construction teams how and why decisions are being made. PMID:23513759

  13. The Integral Fast Reactor

    SciTech Connect

    Chang, Y.I.

    1988-01-01

    The Integral Fast Reactor (IFR) is an innovative liquid metal reactor concept being developed at Argonne National Laboratory. It seeks to specifically exploit the inherent properties of liquid metal cooling and metallic fuel in a way that leads to substantial improvements in the characteristics of the complete reactor system. This paper describes the key features and potential advantages of the IFR concept, with emphasis on its safety characteristics. 3 refs., 4 figs., 1 tab.

  14. PHENIX Fast TOF

    SciTech Connect

    Soha, Aria; Chiu, Mickey; Mannel, Eric; Stoll, Sean; Lynch, Don; Boose, Steve; Northacker, Dave; Alfred, Marcus; Lindesay, James; Chujo, Tatsuya; Inaba, Motoi; Nonaka, Toshihiro; Sato, Wataru; Sakatani, Ikumi; Hirano, Masahiro; Choi, Ihnjea

    2014-01-15

    This is a technical scope of work (TSW) between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of PHENIX Fast TOF group who have committed to participate in beam tests to be carried out during the FY2014 Fermilab Test Beam Facility program. The goals for this test beam experiment are to verify the timing performance of the two types of time-of-flight detector prototypes.

  15. Pupil Transportation.

    ERIC Educational Resources Information Center

    Stollar, Dewey H.

    The purpose of this NEFP satellite study is to provide an overview of pupil transportation. The first phase of the study discusses the early legal and financial bases for student transportation, the second the current status of student transportation, and the third the future status of student transportation needs and financing for 1980.…

  16. Fast Track Study

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The NASA Fast Track Study supports the efforts of a Special Study Group (SSG) made up of members of the Advanced Project Management Class number 23 (APM-23) that met at the Wallops Island Management Education Center from April 28 - May 8, 1996. Members of the Class expressed interest to Mr. Vem Weyers in having an input to the NASA Policy Document (NPD) 7120.4, that will replace NASA Management Institute (NMI) 7120.4, and the NASA Program/Project Management Guide. The APM-23 SSG was tasked with assisting in development of NASA policy on managing Fast Track Projects, defined as small projects under $150 million and completed within three years. 'Me approach of the APM-23 SSG was to gather data on successful projects working in a 'Better, Faster, Cheaper' environment, within and outside of NASA and develop the Fast Track Project section of the NASA Program/Project Management Guide. Fourteen interviews and four other data gathering efforts were conducted by the SSG, and 16 were conducted by Strategic Resources, Inc. (SRI), including five interviews at the Jet Propulsion Laboratory (JPL) and one at the Applied Physics Laboratory (APL). The interviews were compiled and analyzed for techniques and approaches commonly used to meet severe cost and schedule constraints.

  17. The fast Hartley transform

    NASA Astrophysics Data System (ADS)

    Mar, Mark H.

    1990-11-01

    The purpose of this paper is to report the results of testing the fast Hartley transform (FHT) and comparing it with the fast Fourier transform (FFT). All the definitions and equations in this paper are quoted and cited from the series of references. The author of this report developed a FORTRAN program which computes the Hartley transform. He tested the program with a generalized electromagnetic pulse waveform and verified the results with the known value. Fourier analysis is an essential tool to obtain frequency domain information from transient time domain signals. The FFT is a popular tool to process many of today's audio and electromagnetic signals. System frequency response, digital filtering of signals, and signal power spectrum are the most practical applications of the FFT. However, the Fourier integral transform of the FFT requires computer resources appropriate for the complex arithmetic operations. On the other hand, the FHT can accomplish the same results faster and requires fewer computer resources. The FHT is twice as fast as the FFT, uses only half the computer resources, and so could be more useful than the FFT in typical applications such as spectral analysis, signal processing, and convolution. This paper presents a FORTRAN computer program for the FHT algorithm along with a brief description and compares the results and performance of the FHT and the FFT algorithms.

  18. Fasting - the ultimate diet?

    PubMed

    Johnstone, A M

    2007-05-01

    Adult humans often undertake acute fasts for cosmetic, religious or medical reasons. For example, an estimated 14% of US adults have reported using fasting as a means to control body weight and this approach has long been advocated as an intermittent treatment for gross refractory obesity. There are unique historical data sets on extreme forms of food restriction that give insight into the consequences of starvation or semi-starvation in previously healthy, but usually non-obese subjects. These include documented medical reports on victims of hunger strike, famine and prisoners of war. Such data provide a detailed account on how the body adapts to prolonged starvation. It has previously been shown that fasting for the biblical period of 40 days and 40 nights is well within the overall physiological capabilities of a healthy adult. However, the specific effects on the human body and mind are less clearly documented, either in the short term (hours) or in the longer term (days). This review asks the following three questions, pertinent to any weight-loss therapy, (i) how effective is the regime in achieving weight loss, (ii) what impact does it have on psychology? and finally, (iii) does it work long-term? PMID:17444963

  19. Neighborhood fast food availability and fast food consumption.

    PubMed

    Oexle, Nathalie; Barnes, Timothy L; Blake, Christine E; Bell, Bethany A; Liese, Angela D

    2015-09-01

    Recent nutritional and public health research has focused on how the availability of various types of food in a person's immediate area or neighborhood influences his or her food choices and eating habits. It has been theorized that people living in areas with a wealth of unhealthy fast-food options may show higher levels of fast-food consumption, a factor that often coincides with being overweight or obese. However, measuring food availability in a particular area is difficult to achieve consistently: there may be differences in the strict physical locations of food options as compared to how individuals perceive their personal food availability, and various studies may use either one or both of these measures. The aim of this study was to evaluate the association between weekly fast-food consumption and both a person's perceived availability of fast-food and an objective measure of fast-food presence - Geographic Information Systems (GIS) - within that person's neighborhood. A randomly selected population-based sample of eight counties in South Carolina was used to conduct a cross-sectional telephone survey assessing self-report fast-food consumption and perceived availability of fast food. GIS was used to determine the actual number of fast-food outlets within each participant's neighborhood. Using multinomial logistic regression analyses, we found that neither perceived availability nor GIS-based presence of fast-food was significantly associated with weekly fast-food consumption. Our findings indicate that availability might not be the dominant factor influencing fast-food consumption. We recommend using subjective availability measures and considering individual characteristics that could influence both perceived availability of fast food and its impact on fast-food consumption. If replicated, our findings suggest that interventions aimed at reducing fast-food consumption by limiting neighborhood fast-food availability might not be completely effective. PMID

  20. Hispanics in Fast Food Jobs.

    ERIC Educational Resources Information Center

    Charner, Ivan; Fraser, Bryna Shore

    A study examined the employment of Hispanics in the fast-food industry. Data were obtained from a national survey of employees at 279 fast-food restaurants from seven companies in which 194 (4.2 percent) of the 4,660 respondents reported being Hispanic. Compared with the total sample, Hispanic fast-food employees were slightly less likely to be…

  1. Bi-Directional Fast Charging Study Report

    SciTech Connect

    Tyler Gray

    2012-02-01

    This report details the hardware and software infrastructure needed to demonstrate the possibility of utilizing battery power in plug-in hybrid electric vehicles (PHEVs) and electric vehicles (EVs) with a bi directional fast charger to support/offset peak building loads. This document fulfills deliverable requirements for Tasks 1.2.1.2, 1.2.1.3, and 1.2.1.4 of Statement of Work (SOW) No.5799 for Electric Transportation Engineering Corporation, now ECOtality North America (NA) support for the Idaho National Laboratory (INL).

  2. Fast infrared response of YBCO thin films

    NASA Technical Reports Server (NTRS)

    Ballentine, P. H.; Kadin, A. M.; Donaldson, W. R.; Scofield, J. H.; Bajuk, L.

    1990-01-01

    The response to short infrared pulses of some epitaxial YBCO films prepared by sputter deposition and by electron-beam evaporation is reported. The response is found to be essentially bolometric on the ns timescale, with some indirect hints of nonequilibrium electron transport on the ps scale. Fast switching could be obtained either by biasing the switch close to the critical current or by cooling the film below about 20 K. These results are encouraging for potential application to a high-current optically-triggered opening switch.

  3. The fast encryption package

    NASA Technical Reports Server (NTRS)

    Bishop, Matt

    1988-01-01

    The organization of some tools to help improve passwork security at a UNIX-based site is described along with how to install and use them. These tools and their associated library enable a site to force users to pick reasonably safe passwords (safe being site configurable) and to enable site management to try to crack existing passworks. The library contains various versions of a very fast implementation of the Data Encryption Standard and of the one-way encryption functions used to encryp the password.

  4. Simplified fast neutron dosimeter

    DOEpatents

    Sohrabi, Mehdi

    1979-01-01

    Direct fast-neutron-induced recoil and alpha particle tracks in polycarbonate films may be enlarged for direct visual observation and automated counting procedures employing electrochemical etching techniques. Electrochemical etching is, for example, carried out in a 28% KOH solution at room temperature by applying a 2000 V peak-to-peak voltage at 1 kHz frequency. Such recoil particle amplification can be used for the detection of wide neutron dose ranges from 1 mrad. to 1000 rads. or higher, if desired.

  5. FAST NEUTRONIC REACTOR

    DOEpatents

    Snell, A.H.

    1957-12-01

    This patent relates to a reactor and process for carrying out a controlled fast neutron chain reaction. A cubical reactive mass, weighing at least 920 metric tons, of uranium metal containing predominantly U/sup 238/ and having a U/sup 235/ content of at least 7.63% is assembled and the maximum neutron reproduction ratio is limited to not substantially over 1.01 by insertion and removal of a varying amount of boron, the reactive mass being substantially freed of moderator.

  6. Fast Ignitor coupling physics

    SciTech Connect

    Mason, R.J.; Tabak, M.

    1997-10-01

    The Fast Ignitor is an alternate approach to ICF in which short pulse lasers are used to initiate burn at the surface of the compressed DT fuel. The aim is to avoid the need for careful central focusing of final shocks, and possibly to lower substantially the energy requirements for ignition. Ultimately, both goals may prove crucial to Science Based Stockpile Stewardship (SBSS). This will be the case should either emerging energetic needs, or finding difficulties render the presently planned radiative fusion approach to ignition with the NIF impractical. Ignition is a first step towards the achievement of substantial energy and neutron outputs for such Stewardship.

  7. Fast quench reactor method

    SciTech Connect

    Detering, Brent A.; Donaldson, Alan D.; Fincke, James R.; Kong, Peter C.; Berry, Ray A.

    1999-01-01

    A fast quench reaction includes a reactor chamber having a high temperature heating means such as a plasma torch at its inlet and a means of rapidly expanding a reactant stream, such as a restrictive convergent-divergent nozzle at its outlet end. Metal halide reactants are injected into the reactor chamber. Reducing gas is added at different stages in the process to form a desired end product and prevent back reactions. The resulting heated gaseous stream is then rapidly cooled by expansion of the gaseous stream.

  8. Fast quench reactor method

    DOEpatents

    Detering, B.A.; Donaldson, A.D.; Fincke, J.R.; Kong, P.C.; Berry, R.A.

    1999-08-10

    A fast quench reaction includes a reactor chamber having a high temperature heating means such as a plasma torch at its inlet and a means of rapidly expanding a reactant stream, such as a restrictive convergent-divergent nozzle at its outlet end. Metal halide reactants are injected into the reactor chamber. Reducing gas is added at different stages in the process to form a desired end product and prevent back reactions. The resulting heated gaseous stream is then rapidly cooled by expansion of the gaseous stream. 8 figs.

  9. Fast neutron dosimetry

    SciTech Connect

    DeLuca, P.M. Jr.; Pearson, D.W.

    1992-01-01

    This progress report concentrates on two major areas of dosimetry research: measurement of fast neutron kerma factors for several elements for monochromatic and white spectrum neutron fields and determination of the response of thermoluminescent phosphors to various ultra-soft X-ray energies and beta-rays. Dr. Zhixin Zhou from the Shanghai Institute of Radiation Medicine, People's Republic of China brought with him special expertise in the fabrication and use of ultra-thin TLD materials. Such materials are not available in the USA. The rather unique properties of these materials were investigated during this grant period.

  10. Slow and fast light in semiconductors

    NASA Astrophysics Data System (ADS)

    Sedgwick, Forrest Grant

    Slow and fast light are the propagation of optical signals at group velocities below and above the speed of light in a given medium. There has been great interest in the use of nonlinear optics to engineer slow and fast light dispersion for applications in optical communications and radio-frequency or microwave photonics. Early results in this field were primarily confined to dilute atomic systems. While these results were impressive, they had two major barriers to practical application. First, the wavelengths were not compatible with fiber optic telecommunications. More importantly, the bandwidth obtainable in these experiments was inherently low; 100 kHz or less. Within the last five years slow and fast light effects have been observed and engineered in a much wider variety of systems. In this work, we detail our efforts to realize slow and fast light in semiconductor systems. There are three primary advantages of semiconductor systems: fiber-compatible wavelengths, larger bandwidth, and simplification of integration with other optical components. In this work we will explore three different types of physical mechanisms for implementing slow and fast light. The first is electromagnetically induced transparency (EIT). In transporting this process to semiconductors, we initially turn our attention to quantum dots or "artificial atoms". We present simulations of a quantum dot EIT-based device within the context of an optical communications link and we derive results which are generally applicable to a broad class of slow light devices. We then present experimental results realizing EIT in quantum wells by using long-lived electron spin coherence. The second mechanism we will explore is coherent population oscillations (CPO), also known as carrier density pulsations (CDP). We examine for the first time how both slow and fast light may be achieved in a quantum well semiconductor optical amplifier (SOA) while operating in the gain regime. Again, we simulate the device