Science.gov

Sample records for supporting frequent updates

  1. Research Supports Value of Updated School Facilities

    ERIC Educational Resources Information Center

    Fielding, Randall

    2012-01-01

    Two recent peer-reviewed studies support the need to update the traditional school design model that has remained fundamentally unchanged for over a century. In a 2011 study published by the American Educational Research Journal, entitled "Problem-Based Learning in K-12 Education," Clarice Wirkala and Deanna Kuhn document a 200-500 percent…

  2. Extracorporeal life support: updates and controversies.

    PubMed

    Gadepalli, Samir K; Hirschl, Ronald B

    2015-02-01

    The use of Extracorporeal Life Support (ECLS) in children and adults has markedly increased during the past few years with over 4000 patients placed on ECLS every year in over 200 centers. This article focuses on updates to the physiology and mechanics of ECLS with use of magnetically levitated centrifugal pumps, hollow-fiber gas-exchange devices, and bi-caval dual-lumen catheters. We also explore controversies in management including indications, cannulation approaches, renal replacement, monitoring of anticoagulation, early ambulation, and termination of ECLS. Finally, we present changes in the systems that provide ECLS including the single-provider model and regionalization of care. PMID:25639803

  3. ASDSO updates bibliography, creates support database

    SciTech Connect

    Spragens, L. )

    1993-04-01

    The Association of State Dam Safety Officials has updated its Bibliography of Dam Safety Practices, originally published in 1990 with assistance from the US Committee on Large Dams. The new document lists publications addressing dam safety issues and includes 20 subject headings. The Federal Emergency Management Agency underwrote the update, which includes information about journal articles on dam safety, conference presentations, and new books and manuals. The publication also contains information about obtaining copies of the documents. The bibliography features a new section on use of geosynthetics in dam safety, compiled by Greg Hammer, of ASDSO's Technical Committee. Dam break analysis, emergency action planning, instrumentation, inspections, overtopping of dams, rehabilitation of dams, risk analysis, and seismic behavior are also included. In conjunction with the release of the updated bibliography, ASDSO is creating a computer database for its members that contains information from the bibliography. ASDSO also is in the process of adding information to the database about current research in dam safety. When the database becomes available later this year, members will be able to search for information on research in a specific subject area. Users also will be able to search for research groups, individuals, and universities to obtain an overview of who is conducting research in dam safety. Additionally, the database will allow the user to search for subject matter experts when looking for conference speakers and writers with specific specialties.

  4. Drug Free Communities Support Program. Prevention Update

    ERIC Educational Resources Information Center

    Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2012

    2012-01-01

    Administered by the Office of National Drug Control Policy (ONDCP), in partnership with the Substance Abuse and Mental Health Services Administration (SAMHSA), the Drug Free Communities Support Program (DFC) is a federal grant program that provides funding to community-based coalitions that organize to prevent youth substance use. Since the…

  5. A Use Case to Support Precision Medicine for Frequently Hospitalized Older Adults with Polypharmacy.

    PubMed

    Cabrera, Manuel; Finkelstein, Joseph

    2016-01-01

    Polypharmacy in older adults results in multiple negative clinical consequences including increased risk of hospital readmissions. Precision medicine may provide tools to optimize complex medication regimens however its potential in older adults with polypharmacy is unknown. We carried out pharmacogenetic testing in an older adult with multiple chronic conditions and polypharmacy who was concerned about frequent readmissions despite receiving guideline-concordant care and being adherent to medication regimen. The testing identified patients' CYP2D6 rapid metabolizer status. This may have resulted in decreased exposure to Carvedilol which was primary drug for CHF management in this patient. Additional nine drug-drug interactions were identified during personalized drug regimen review. We concluded that, though precision medicine has enormous potential in older adults with polypharmacy, the complexity of pharmacogenetic information requires innovative informatics solutions to support optimal workflows, decision support, and medication optimization and management in order to fully utilize its potential in routine clinical care. PMID:27570642

  6. A Use Case to Support Precision Medicine for Frequently Hospitalized Older Adults with Polypharmacy

    PubMed Central

    Cabrera, Manuel; Finkelstein, Joseph

    2016-01-01

    Polypharmacy in older adults results in multiple negative clinical consequences including increased risk of hospital readmissions. Precision medicine may provide tools to optimize complex medication regimens however its potential in older adults with polypharmacy is unknown. We carried out pharmacogenetic testing in an older adult with multiple chronic conditions and polypharmacy who was concerned about frequent readmissions despite receiving guideline-concordant care and being adherent to medication regimen. The testing identified patients’ CYP2D6 rapid metabolizer status. This may have resulted in decreased exposure to Carvedilol which was primary drug for CHF management in this patient. Additional nine drug-drug interactions were identified during personalized drug regimen review. We concluded that, though precision medicine has enormous potential in older adults with polypharmacy, the complexity of pharmacogenetic information requires innovative informatics solutions to support optimal workflows, decision support, and medication optimization and management in order to fully utilize its potential in routine clinical care. PMID:27570642

  7. Advanced integrated life support system update

    NASA Technical Reports Server (NTRS)

    Whitley, Phillip E.

    1994-01-01

    The Advanced Integrated Life Support System Program (AILSS) is an advanced development effort to integrate the life support and protection requirements using the U.S. Navy's fighter/attack mission as a starting point. The goal of AILSS is to optimally mate protection from altitude, acceleration, chemical/biological agent, thermal environment (hot, cold, and cold water immersion) stress as well as mission enhancement through improved restraint, night vision, and head-mounted reticules and displays to ensure mission capability. The primary emphasis to date has been to establish garment design requirements and tradeoffs for protection. Here the garment and the human interface are treated as a system. Twelve state-off-the-art concepts from government and industry were evaluated for design versus performance. On the basis of a combination of centrifuge, thermal manikin data, thermal modeling, and mobility studies, some key design parameters have been determined. Future efforts will concentrate on the integration of protection through garment design and the use of a single layer, multiple function concept to streamline the garment system.

  8. 7. Mentor update and support: what do mentors need from an update?

    PubMed

    Phillips, Mari; Marshall, Joyce

    2015-04-01

    Mentorship is the 14th series of 'Midwifery basics' targeted at practising midwives. The aim of these articles is to provide information to raise awareness of the impact of the work of midwives on women's experience, and encourage midwives to seek further information through a series of activities relating to the topic. In this seventh article Mari Phillips and Joyce Marshall consider some of the key issues related to mentor update and support and consider what mentors need from their annual update. PMID:26328467

  9. Mitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling

    PubMed Central

    Eisner, Verónica; Lenaers, Guy

    2014-01-01

    Genetic targeting experiments indicate a fundamental role for mitochondrial fusion proteins in mammalian physiology. However, owing to the multiple functions of fusion proteins, their related phenotypes are not necessarily caused by altered mitochondrial fusion. Perhaps the biggest mystery is presented by skeletal muscle, where mostly globular-shaped mitochondria are densely packed into the narrow intermyofilamental space, limiting the interorganellar interactions. We show here that mitochondria form local networks and regularly undergo fusion events to share matrix content in skeletal muscle fibers. However, fusion events are less frequent and more stable in the fibers than in nondifferentiated myoblasts. Complementation among muscle mitochondria was suppressed by both in vivo genetic perturbations and chronic alcohol consumption that cause myopathy. An Mfn1-dependent pathway is revealed whereby fusion inhibition weakens the metabolic reserve of mitochondria to cause dysregulation of calcium oscillations during prolonged stimulation. Thus, fusion dynamically connects skeletal muscle mitochondria and its prolonged loss jeopardizes bioenergetics and excitation–contraction coupling, providing a potential pathomechanism contributing to myopathies. PMID:24751540

  10. LANDFIRE 2010 - updated data to support wildfire and ecological management

    USGS Publications Warehouse

    Nelson, Kurtis J.; Connot, Joel A.; Peterson, Birgit; Picotte, Joshua J.

    2013-01-01

    Wildfire is a global phenomenon that affects human populations and ecosystems. Wildfire effects occur at local to global scales impacting many people in different ways (Figure 1). Ecological concerns due to land use, fragmentation, and climate change impact natural resource use, allocation, and conservation. Access to consistent and current environmental data is a constant challenge, yet necessary for understanding the complexities of wildfire and ecological management. Data products and tools from the LANDFIRE Program help decision-makers to clarify problems and identify possible solutions when managing fires and natural resources. LANDFIRE supports the reduction of risk from wildfire to human lives and property, monitoring of fire danger, prediction of fire behavior on active incidents, and assessment of fire severity and impacts on natural systems [1] [2] [3]. LANDFIRE products are unique in that they are nationally consistent and provide the only complete geospatial dataset describing vegetation and wildland fuel information for the entire U.S. As such, LANDFIRE data are useful for many ecological applications [3]. For example, LANDFIRE data were recently integrated into a decision-support system for resource management and conservation decision-making along the Appalachian Trail. LANDFIRE is a joint effort between the U.S. Department of the Interior Office of Wildland Fire, U.S. Department of Agriculture Forest Service Fire & Aviation Management, and The Nature Conservancy. To date, seven versions of LANDFIRE data have been released, with each successive version improving the quality of the data, adding additional features, and/or updating the time period represented by the data. The latest version, LANDFIRE 2010 (LF 2010), released mid-2013, represents circa 2010 landscape conditions and succeeds LANDFIRE 2008 (LF 2008), which represented circa 2008 landscape conditions. LF 2010 used many of the same processes developed for the LF 2008 effort [3]. Ongoing

  11. Updated plan for support of research related to geothermal reservoir engineering

    SciTech Connect

    Howard, J.H.; Goldstein, N.E.; Graf, A.N.

    1980-09-01

    The original plan for support of research in geothermal reservoir engineering, GREMP, is reviewed and compared with accomplishments to date. A commentary on the comparison and an updated plan are presented. Also included are a justification of the updated plan and a revised management plan. (MHR)

  12. An Update on NiCE Support for BISON

    SciTech Connect

    McCaskey, Alex; Billings, Jay Jay; Deyton, Jordan H.; Wojtowicz, Anna

    2015-09-01

    The Nuclear Energy Advanced Modeling and Simulation program (NEAMS) from the Department of Energy s Office of Nuclear Energy has funded the development of a modeling and simulation workflow environment to support the various codes in its nuclear energy scientific computing toolkit. This NEAMS Integrated Computational Environment (NiCE) provides extensible tools and services that enable efficient code execution, input generation, pre-processing visualizations, and post-simulation data analysis and visualization for a large portion of the NEAMS Toolkit. A strong focus for the NiCE development team throughout FY 2015 has been support for the Multiphysics Object Oriented Simulation Environment (MOOSE) and the NEAMS nuclear fuel performance modeling application built on that environment, BISON. There is a strong desire in the program to enable and facilitate the use of BISON throughout nuclear energy research and industry. A primary result of this desire is the need for strong support for BISON in NiCE. This report will detail improvements to NiCE support for BISON. We will present a new and improved interface for interacting with BISON simulations in a variety of ways: (1) improved input model generation, (2) embedded mesh and solution data visualizations, and (3) local and remote BISON simulation launch. We will also show how NiCE has been extended to provide support for BISON code development.

  13. Update on Activities of CEOS Disaster Management Support Group

    NASA Astrophysics Data System (ADS)

    Wood, H. M.; Lauritson, L.

    The Committee on Earth Observation Satellites (CEOS) Disaster Management Support Group (DMSG) has supported natural and technological disaster management on a worldwide basis by fostering improved utilization of existing and planned Earth Observation (EO) satellite data. The DMSG has focused on developing and refining recommendations for the application of satellite data to selected hazard areas--drought, earthquake, fire, flood, ice, landslide, oil spill, and volcanic hazards. Particular emphasis was placed on working closely with space agencies, international and regional organizations, and commercial organizations on the implementation of these recommendations. The DMSG is in its last year with its primary focus on documenting its work and migrating on going activities to other fora. With over 300 participants from more than 140 organizations, the DMSG has found strong support among CEOS space agencies and the Integrated Global Observing Strategy (IGOS), as well as an enthusiastic reception from numerous international, regional, and national emergency managers, and distinct interest from the commercial sector. In addition, the group has worked to give full support to the work of the United Nations Committee on the Peaceful Uses of Outer Space (COPUOS) in pursuit of decisions taken at UNISPACE III and the United Nations International Strategy on Disaster Reduction (ISDR). In conjunction with the IGOS, several of the DMSG hazards teams (earthquake, landslide, and solid Earth dimensions of volcanoes) are joining in the effort to develop an IGOS Geohazards theme team. Cooperation efforts with organizations such as IGOS, COPUOS, and ISDR will hopefully lead to the pick up of much of the on going DMSG activities. Since the inception of this ad hoc working group and its predecessor project, the DMSG has developed and refined recommendations for the application of satellite data by bringing together experts from eight hazard areas to identify user needs, as well as

  14. Frequent Urination

    MedlinePlus

    ... leader Partner Spotlight Become a partner World Prematurity Day Your support helps babies We are determined to ... very strong. After birth For the first few days after delivery, you may urinate even more often ...

  15. Keratoconus Frequently Asked Questions

    MedlinePlus

    ... Presentations More Links Research Research Update Clinical Trials News E-Updates Products Press Releases Papers Events The NKCF Virtual ... Presentations More Links Research Research Update Clinical Trials News E-Updates Products Press Releases Papers Events The NKCF Virtual ...

  16. Medical support of the Sinai Multinational Force and Observers: an update, 2001.

    PubMed

    Rowe, John R

    2003-02-01

    The Multinational Force and Observers is an 11-nation coalition force with the mission of peacekeeping in the Sinai. It commenced operations in 1982 and continues today after two decades of successful enforcement of the 1979 Egyptian-Israeli Treaty of Peace. The fielding of a medical support team for this mission was the first effort of its kind for the U.S. Army Medical Department, resulting in a uniquely organized medical unit. A U.S. Army physician heads the medical team, which includes nine other physicians from six different countries. The team provides health care for the 2,500-person coalition in the remote Sinai desert. This writing compares earlier medical support with that of August 2000 through July 2001 and describes medical conditions and problems encountered during the 12-month tour of duty. This article updates two previous articles on the subject published in Military Medicine in 1983 and 1991. PMID:12636137

  17. An Update on Improvements to NiCE Support for RELAP-7

    SciTech Connect

    McCaskey, Alex; Wojtowicz, Anna; Deyton, Jordan H.; Patterson, Taylor C.; Billings, Jay Jay

    2015-01-01

    The Multiphysics Object-Oriented Simulation Environment (MOOSE) is a framework that facilitates the development of applications that rely on finite-element analysis to solve a coupled, nonlinear system of partial differential equations. RELAP-7 represents an update to the venerable RELAP-5 simulator that is built upon this framework and attempts to model the balance-of-plant concerns in a full nuclear plant. This report details the continued support and integration of RELAP-7 and the NEAMS Integrated Computational Environment (NiCE). RELAP-7 is fully supported by the NiCE due to on-going work to tightly integrate NiCE with the MOOSE framework, and subsequently the applications built upon it. NiCE development throughout the first quarter of FY15 has focused on improvements, bug fixes, and feature additions to existing MOOSE-based application support. Specifically, this report will focus on improvements to the NiCE MOOSE Model Builder, the MOOSE application job launcher, and the 3D Nuclear Plant Viewer. This report also includes a comprehensive tutorial that guides RELAP-7 users through the basic NiCE workflow: from input generation and 3D Plant modeling, to massively parallel job launch and post-simulation data visualization.

  18. Differentially Private Frequent Subgraph Mining

    PubMed Central

    Xu, Shengzhi; Xiong, Li; Cheng, Xiang; Xiao, Ke

    2016-01-01

    Mining frequent subgraphs from a collection of input graphs is an important topic in data mining research. However, if the input graphs contain sensitive information, releasing frequent subgraphs may pose considerable threats to individual's privacy. In this paper, we study the problem of frequent subgraph mining (FGM) under the rigorous differential privacy model. We introduce a novel differentially private FGM algorithm, which is referred to as DFG. In this algorithm, we first privately identify frequent subgraphs from input graphs, and then compute the noisy support of each identified frequent subgraph. In particular, to privately identify frequent subgraphs, we present a frequent subgraph identification approach which can improve the utility of frequent subgraph identifications through candidates pruning. Moreover, to compute the noisy support of each identified frequent subgraph, we devise a lattice-based noisy support derivation approach, where a series of methods has been proposed to improve the accuracy of the noisy supports. Through formal privacy analysis, we prove that our DFG algorithm satisfies ε-differential privacy. Extensive experimental results on real datasets show that the DFG algorithm can privately find frequent subgraphs with high data utility.

  19. Supporting Documentation for the 2008 Update to the Insulation Fact Sheet

    SciTech Connect

    Stovall, Therese K

    2008-02-01

    The Insulation Fact Sheet provides consumers for general guidance and recommended insulation levels for their home. This fact sheet has been on-line since 1995 and this update addresses new insulation materials, as well as updated costs for energy and materials.

  20. Case management and self-management support for frequent users with chronic disease in primary care: a pragmatic randomized controlled trial

    PubMed Central

    2013-01-01

    Background Chronic diseases represent a major challenge for health care and social services. A number of people with chronic diseases require more services due to characteristics that increase their vulnerability. Given the burden of increasingly vulnerable patients on primary care, a pragmatic intervention in four Family Medicine Groups (primary care practices in Quebec, Canada) has been proposed for individuals with chronic diseases (diabetes, cardiovascular diseases, respiratory diseases, musculoskeletal diseases and/or chronic pain) who are frequent users of hospital services. The intervention combines case management by a nurse with group support meetings encouraging self-management based on the Stanford Chronic Disease Self-Management Program. The goals of this study are to: (1) analyze the implementation of the intervention in the participating practices in order to determine how the various contexts have influenced the implementation and the observed effects; (2) evaluate the proximal (self-efficacy, self-management, health habits, activation and psychological distress) and intermediate (empowerment, quality of life and health care use) effects of the intervention on patients; (3) conduct an economic analysis of the efficiency and cost-effectiveness of the intervention. Methods/Design The analysis of the implementation will be conducted using realistic evaluation and participatory approaches within four categories of stakeholders (Family Medicine Group and health centre management, Family Medicine Group practitioners, patients and their families, health centre or community partners). The data will be obtained through individual and group interviews, project documentation reviews and by documenting the intervention. Evaluation of the effects on patients will be based on a pragmatic randomized before-after experimental design with a delayed intervention control group (six months). Economic analysis will include cost-effectiveness and cost-benefit analysis

  1. Responding to Changes in Building Legislation. Updating Training for the Building Regulations 1985 and Supporting Documents.

    ERIC Educational Resources Information Center

    Harris, Robert; Phillips, Alan

    A project sought to develop a means of updating and retraining those required to comply with Britain's 1985 Building Regulations, which are substantially different from the previous ones in regard to procedures and technical content. The training needs analysis conducted indicated that the new training should be flexible and use practical and…

  2. E-1 Dynamic Fluid-Flow Model Update: EASY/ROCETS Enhancement and Model Development Support

    NASA Technical Reports Server (NTRS)

    Follett, Randolph F.; Taylor, Robert P.

    1998-01-01

    This report documents the research conducted to update computer models for dynamic fluid flow simulation of the E-1 test stand subsystems at te NASA John C. Stennis Space Center.Work also involved significant upgrades to the capabilities of EASY/ROCKETS library through the inclusion of the NIST-12 thermodynamic property database and development of new control system modules.

  3. Empirical Evidence Supporting Frequent Cryptic Speciation in Epiphyllous Liverworts: A Case Study of the Cololejeunea lanciloba Complex

    PubMed Central

    Yu, Ying; Heinrichs, Jochen; Zhu, Rui-Liang; Schneider, Harald

    2013-01-01

    Cryptic species are frequently recovered in plant lineages, and considered an important cause for divergent of morphological disparity and species diversity. The identification of cryptic species has important implications for the assessment of conservation needs of species aggregates. The mechanisms and processes of the origin of cryptic species diversity are still poorly understand based on the lack of studies especially in context of environment factors. Here we explored evidence for cryptic species within the epiphyllous liverworts Cololejeunea lanciloba complex based on two loci, the plastid trnL-F region and the nuclear ribosomal ITS region. Several analytic approaches were employed to delimit species based on DNA sequence variation including phylogenetic reconstruction, statistical parsimony networks analysis and two recently introduced species delimitation criteria: Rosenberg’s reciprocal monophyly and Rodrigo’s randomly distinct. We found evidence for thirteen genetically distinct putative species, each consisting of more than one haplotype, rather than four morphologically-circumscribed species. The results implied that the highly conserved phenotypes are not congruent with the genetic differentiation, contributing to incorrect assessments of the biodiversity of epiphyllous liverworts. We hypothesize that evolution of cryptic species recovered may be caused by selection of traits critical to the survival in epiphyllous habitats combined with limited developmental options designed in the small body. PMID:24367634

  4. Updates on the Construction of an Eyeglass-Supported Nasal Prosthesis Using Computer-Aided Design and Rapid Prototyping Technology.

    PubMed

    Ciocca, Leonardo; Tarsitano, Achille; Marchetti, Claudio; Scotti, Roberto

    2016-01-01

    This study was undertaken to design an updated connection system for an eyeglass-supported nasal prosthesis using rapid prototyping techniques. The substructure was developed with two main endpoints in mind: the connection to the silicone and the connection to the eyeglasses. The mold design was also updated; the mold was composed of various parts, each carefully designed to allow for easy release after silicone processing and to facilitate extraction of the prosthesis without any strain. The approach used in this study enabled perfect transfer of the reciprocal position of the prosthesis with respect to the eyeglasses, from the virtual to the clinical environment. Moreover, the reduction in thickness improved the flexibility of the prosthesis and promoted adaptation to the contours of the skin, even during functional movements. The method described here is a simplified and viable alternative to standard construction techniques for nasal prostheses and offers improved esthetic and functional results when no bone is available for implant-supported prostheses. PMID:26288248

  5. Five-Year Progress Update on the Surgeon General's Call to Action to Support Breastfeeding, 2011.

    PubMed

    Anstey, Erica H; MacGowan, Carol A; Allen, Jessica A

    2016-08-01

    In 2011, Surgeon General Regina Benjamin issued a Call to Action to Support Breastfeeding (Call to Action) in an effort to mobilize families, communities, clinicians, healthcare systems, and employers to take action to improve support for breastfeeding. The Call to Action identified 20 key action steps to address society-wide breastfeeding barriers in six areas: mothers and families, communities, healthcare, employment, research, and public health infrastructure. This report highlights major federal activities that show progress toward answering the Call to Action in the first 5 years since its launch. PMID:27463691

  6. Positive Behavior Support: A Proposal for Updating and Refining the Definition

    ERIC Educational Resources Information Center

    Kincaid, Don; Dunlap, Glen; Kern, Lee; Lane, Kathleen Lynne; Bambara, Linda M.; Brown, Fredda; Fox, Lise; Knoster, Timothy P.

    2016-01-01

    Positive behavior support (PBS) has been a dynamic and growing enterprise for more than 25 years. During this period, PBS has expanded applications across a wide range of populations and multiple levels of implementation. As a result, there have been understandable inconsistencies and confusion regarding the definition of PBS. In this essay, we…

  7. The Empirically Supported Status of Acceptance and Commitment Therapy: An Update

    ERIC Educational Resources Information Center

    Smout, Matthew F.; Hayes, Louise; Atkins, Paul W. B.; Klausen, Jessica; Duguid, James E.

    2012-01-01

    Acceptance and commitment therapy (ACT) is a transdiagnostic cognitive behavioural therapy that predominantly teaches clients acceptance and mindfulness skills, as well as values clarification and enactment skills. Australian treatment guideline providers have been cautious in recognising ACT as empirically supported. This article reviews evidence…

  8. ArrayTrack: a free FDA bioinformatics tool to support emerging biomedical research--an update.

    PubMed

    Xu, Joshua; Kelly, Reagan; Fang, Hong; Tong, Weida

    2010-08-01

    ArrayTrack is a Food and Drug Administration (FDA) bioinformatics tool that has been widely adopted by the research community for genomics studies. It provides an integrated environment for microarray data management, analysis and interpretation. Most of its functionality for statistical, pathway and gene ontology analysis can also be applied independently to data generated by other molecular technologies. ArrayTrack has been undergoing active development and enhancement since its inception in 2001. This review summarises its key functionalities, with emphasis on the most recent extensions in support of the evolving needs of FDA's research programmes. ArrayTrack has added capability to manage, analyse and interpret proteomics and metabolomics data after quantification of peptides and metabolites abundance, respectively. Annotation information about single nucleotide polymorphisms and quantitative trait loci has been integrated to support genetics-related studies. Other extensions have been added to manage and analyse genomics data related to bacterial food-borne pathogens. PMID:20846933

  9. Node 3 Relocation Environmental Control and Life Support System Modification Kit Verification and Updated Status

    NASA Technical Reports Server (NTRS)

    Williams, David E.; Spector Lawrence N.

    2010-01-01

    Node 1 (Unity) flew to International Space Station (ISS) on Flight 2A. Node 1 was the first module of the United States On-Orbit Segment (USOS) launched to ISS. The Node 1 ISS Environmental Control and Life Support (ECLS) design featured limited ECLS capability. The main purpose of Node 1 was to provide internal storage by providing four stowage rack locations within the module and to allow docking of multiple modules and a truss segment to it. The ECLS subsystems inside Node 1 were routed through the element prior to launch to allow for easy integration of the attached future elements, particularly the Habitation Module which was planned to be located at the nadir docking port of Node 1. After Node I was on-orbit, the Program decided not to launch the Habitation Module and instead, to replace it with Node 3 (Tranquility). In 2007, the Program became concerned with a potential Russian docking port approach issue for the Russian FGB nadir docking port after Node 3 is attached to Node 1. To solve this concern the Program decided to relocate Node 3 from Node I nadir to Node 1 port. To support the movement of Node 3 the Program decided to build a modification kit for Node 1, an on-orbit feedthrough leak test device, and new vestibule jumpers to support the ECLS part of the relocation. This paper provides a design overview of the modification kit for Node 1, a summary of the Node 1 ECLS re-verification to support the Node 3 relocation from Node 1 nadir to Node 1 port, and a status of the ECLS modification kit installation into Node 1.

  10. Node 3 Relocation Environmental Control and Life Support System Modification Kit Verification and Updated Status

    NASA Technical Reports Server (NTRS)

    Williams, David E.; Spector, Lawrence N.

    2009-01-01

    Node 1 (Unity) flew to International Space Station (ISS) on Flight 2A. Node 1 was the first module of the United States On-Orbit Segment (USOS) launched to ISS. The Node 1 ISS Environmental Control and Life Support (ECLS) design featured limited ECLS capability. The main purpose of Node 1 was to provide internal storage by providing four stowage rack locations within the module and to allow docking of multiple modules and a truss segment to it. The ECLS subsystems inside Node 1 were routed through the element prior to launch to allow for easy integration of the attached future elements, particularly the Habitation Module which was planned to be located at the nadir docking port of Node 1. After Node 1 was on-orbit, the Program decided not to launch the Habitation Module and instead, to replace it with Node 3 (Tranquility). In 2007, the Program became concerned with a potential Russian docking port approach issue for the Russian FGB nadir docking port after Node 3 is attached to Node 1. To solve this concern the Program decided to relocate Node 3 from Node 1 nadir to Node 1 port. To support the movement of Node 3 the Program decided to build a modification kit for Node 1, an on-orbit feedthrough leak test device, and new vestibule jumpers to support the ECLS part of the relocation. This paper provides a design overview of the modification kit, a summary of the Node 1 ECLS re-verification to support the Node 3 relocation from Node 1 nadir to Node 1 port, and a status of the ECLS modification kit installation into Node 1.

  11. An Update on Improvements to NiCE Support for PROTEUS

    SciTech Connect

    Bennett, Andrew; McCaskey, Alexander J.; Billings, Jay Jay

    2015-09-01

    The Department of Energy Office of Nuclear Energy s Nuclear Energy Advanced Modeling and Simulation (NEAMS) program has supported the development of the NEAMS Integrated Computational Environment (NiCE), a modeling and simulation workflow environment that provides services and plugins to facilitate tasks such as code execution, model input construction, visualization, and data analysis. This report details the developement of workflows for the reactor core neutronics application, PROTEUS. This advanced neutronics application (primarily developed at Argonne National Laboratory) aims to improve nuclear reactor design and analysis by providing an extensible and massively parallel, finite-element solver for current and advanced reactor fuel neutronics modeling. The integration of PROTEUS-specific tools into NiCE is intended to make the advanced capabilities that PROTEUS provides more accessible to the nuclear energy research and development community. This report will detail the work done to improve existing PROTEUS workflow support in NiCE. We will demonstrate and discuss these improvements, including the development of flexible IO services, an improved interface for input generation, and the addition of advanced Fortran development tools natively in the platform.

  12. Update on the Ares V to Support Heavy Lift for U.S. Space Exploration Policy

    NASA Technical Reports Server (NTRS)

    Sumrall, John P.; Creech, Steve

    2008-01-01

    When NASA's Ares V cargo launch vehicle begins flying late next decade, its capabilities will significantly exceed the 1960s-era Saturn V. It will send more crew and cargo to more places on the lunar surface than Apollo and provide ongoing support to a permanent lunar outpost that will open the Moon to greater exploration, science and adventure than ever before. Moreover, it will restore the United States heavy-lift capability, which can support human and robotic exploration for decades to come. Ares V remains in a pre-design analysis cycle stage pending a planned Authority to Proceed (ATP) in late 2010. Ares V benefits from the decision to draw from heritage hardware and its commonality with the Ares I crew launch vehicle, which completed its preliminary design review (PDR) in September 2008. Most of the work on Ares V to date has been focused on refining the vehicle design through a variety of internal studies. This paper will provide background information on the Ares V evolution, emphasizing the vehicle configuration as it exists today.

  13. Space Station Environmental Control and Life Support Systems: An Update on Waste Water Reclamation

    NASA Technical Reports Server (NTRS)

    Ferner, Kathleen M.

    1994-01-01

    Since the mid-1980's, work has been ongoing In the development of the various environmental control and life support systems (ECLSS) for the space station. Part of this effort has been focused on the development of a new subsystem to reclaim waste water that had not been previously required for shuttle missions. Because of the extended manned missions proposed, reclamation of waste water becomes imperative to avoid the weight penalties associated with resupplying a crew's entire water needs for consumption and daily hygiene. Hamilton Standard, under contract to Boeing Aerospace and Electronics, has been designing the water reclamation system for space station use. Since June of 1991, Hamilton Standard has developed a combined water processor capable of reclaiming potable quality water from waste hygiene water, used laundry water, processed urine, Shuttle fuel cell water, humidity condensate and other minor waste water sources. The system was assembled and then tested with over 27,700 pounds of 'real' waste water. During the 1700 hours of system operation required to process this waste water, potable quality water meeting NASA and Boeing specifications was produced. This paper gives a schematic overview of the system, describes the test conditions and test results and outlines the next steps for system development.

  14. Update on the Ares V to Support Heavy Lift for U.S. Space Exploration Policy

    NASA Technical Reports Server (NTRS)

    Creech, Steve

    2008-01-01

    The focus of design efforts in the near future will be on the primary Lunar mission. We are currently just beginning to integrate the design functions from the various centers for this mission. We appreciate all thoughts and ideas for different ways to use the Ares V platform. The Ares V can support an order of magnitude more science instrumentation for outer planetary exploration missions. It can also reach outer planets such as Neptune and other high energy insertion destinations. Current Ares V Point-of-Departure (51.00.48) exceeds Saturn mass capability by approx.40%. Ares V Lunar Capabilities Concept Review analysis focused on meeting lunar requirements and developing margin. Ares V is sensitive to Loiter, Attitude, Power, and Altitude requirements in addition to payload performance. LCCR-approved 51.00.48 POD 5.5-segment steel case booster/6 engine core) Ares V can meet current Human Lunar Return requirements with approx.6 mT of Margin. LCCR-approved 51.00.47 option maintained (5 segment HTPB composite case booster/6 engine core) can meet HLR requirement with more than 9 mT Margin. Ares V team is actively reaching out to external organizations during this early concept phase to ensure that the Ares V vehicle can be leveraged for national security, scientific and commercial development needs.

  15. An Updated Decision Support Interface: A Tool for Remote Monitoring of Crop Growing Conditions

    NASA Astrophysics Data System (ADS)

    Husak, G. J.; Budde, M. E.; Rowland, J.; Verdin, J. P.; Funk, C. C.; Landsfeld, M. F.

    2014-12-01

    Remote sensing of agroclimatological variables to monitor food production conditions is a critical component of the Famine Early Warning Systems Network portfolio of tools for assessing food security in the developing world. The Decision Support Interface (DSI) seeks to integrate a number of remotely sensed and modeled variables to create a single, simplified portal for analysis of crop growing conditions. The DSI has been reformulated to incorporate more variables and give the user more freedom in exploring the available data. This refinement seeks to transition the DSI from a "first glance" agroclimatic indicator to one better suited for the differentiation of drought events. The DSI performs analysis of variables over primary agricultural zones at the first sub-national administrative level. It uses the spatially averaged rainfall, normalized difference vegetation index (NDVI), water requirement satisfaction index (WRSI), and actual evapotranspiration (ETa) to identify potential hazards to food security. Presenting this information in a web-based client gives food security analysts and decision makers a lightweight portal for information on crop growing conditions in the region. The crop zones used for the aggregation contain timing information which is critical to the DSI presentation. Rainfall and ETa are accumulated from different points in the crop phenology to identify season-long deficits in rainfall or transpiration that adversely affect the crop-growing conditions. Furthermore, the NDVI and WRSI serve as their own seasonal accumulated measures of growing conditions by capturing vegetation vigor or actual evapotranspiration deficits. The DSI is currently active for major growing regions of sub-Saharan Africa, with intention of expanding to other areas over the coming years.

  16. Arthritis: Frequently Asked Questions

    MedlinePlus

    ... artritis FAQs Download Spanish Materials Download English Materials Marketing and Support Ambassador Outreach Coordinator’s Guide Person-to- ... to Provider Outreach Provider Outreach Videos Developing a Marketing and Promotion Plan Preparing for Provider Outreach Conducting ...

  17. Financial assistance to states and tribes to support emergency preparedness and response and the safe transportation of hazardous shipments: 1996 Update

    SciTech Connect

    Bradbury, J.A.; Leyson, J.; Lester, M.K.

    1996-07-01

    This report revises and updates the 1995 report Financial Assistance to States and Tribes to Support Emergency Preparedness and Response and the Safe Transportation of Hazardous Shipments, PNL-10260 (UC-620). The presentation of data and some of the data reported have been changed; these data supersede those presented in the earlier publication. All data have been updated to fiscal year 1995, with the exception of FEMA data that are updated to fiscal year 1994 only. The report identifies and summarizes existing sources of financial assistance to States and Tribes in preparing and responding to transportation emergencies and ensuring the safe transportation of hazardous shipments through their jurisdictions. It is intended for use as an information resource for the U.S. Department of Energy`s Office of Environmental Management (EM), Office of Transportation, Emergency Management, and Analytical Services (EM-76).

  18. LANDFIRE 2010—Updates to the national dataset to support improved fire and natural resource management

    USGS Publications Warehouse

    Nelson, Kurtis J.; Long, Donald G.; Connot, Joel A.

    2016-01-01

    The Landscape Fire and Resource Management Planning Tools (LANDFIRE) 2010 data release provides updated and enhanced vegetation, fuel, and fire regime layers consistently across the United States. The data represent landscape conditions from approximately 2010 and are the latest release in a series of planned updates to maintain currency of LANDFIRE data products. Enhancements to the data products included refinement of urban areas by incorporating the National Land Cover Database 2006 land cover product, refinement of agricultural lands by integrating the National Agriculture Statistics Service 2011 cropland data layer, and improved wetlands delineations using the National Land Cover Database 2006 land cover and the U.S. Fish and Wildlife Service National Wetlands Inventory data. Disturbance layers were generated for years 2008 through 2010 using remotely sensed imagery, polygons representing disturbance events submitted by local organizations, and fire mapping program data such as the Monitoring Trends in Burn Severity perimeters produced by the U.S. Geological Survey and the U.S. Forest Service. Existing vegetation data were updated to account for transitions in disturbed areas and to account for vegetation growth and succession in undisturbed areas. Surface and canopy fuel data were computed from the updated vegetation type, cover, and height and occasionally from potential vegetation. Historical fire frequency and succession classes were also updated. Revised topographic layers were created based on updated elevation data from the National Elevation Dataset. The LANDFIRE program also released a new Web site offering updated content, enhanced usability, and more efficient navigation.

  19. An Internet-based intervention for eating disorders consisting of automated computer-tailored feedback with or without supplemented frequent or infrequent support from a coach: study protocol for a randomized controlled trial

    PubMed Central

    2013-01-01

    Background Several Internet-based interventions for eating disorders have shown their effectiveness. Still, there is a need to refine such interventions given that most existing programs seem to be limited by their static ‘one-size-fits-all’ approach. ‘Featback’, an Internet-based intervention for symptoms of eating disorders provides a more individualized approach. It consists of several components (psychoeducation, a fully automated monitoring and feedback system, and support from a coach), which can be matched to participants’ needs and preferences. Until now, it is unclear whether online self-help interventions for eating disorders with support are more effective than those without. The aims of the current study are i) to examine the relative effectiveness of (the different components of) Featback; ii) to examine predictors, moderators and mediators of intervention responses; iii) to report on practical experiences with Featback; and iv) to examine the cost-effectiveness of Featback. Methods/design Individuals aged 16 years or older, with mild to severe eating disorder symptoms will be randomized to one of the four study conditions. In condition one, participants receive the basic version of Featback, consisting of psychoeducation and a fully automated monitoring and feedback system. In conditions two and three, participants receive the basic version of Featback supplemented with the possibility of infrequent (weekly) or frequent (three times a week) e-mail, chat, or Skype support from a coach, respectively. The fourth condition is a waiting list control condition. Participants are assessed at baseline, post-intervention (8 weeks), and at 3- and 6-month follow-up (the latter except for participants in the waiting list control condition). Primary outcome measures are disordered eating behaviors and attitudes. Secondary outcome measures are (eating disorder-related) quality of life, self-stigma of seeking help, self-esteem, mastery and support, symptoms

  20. Updating of ASME Nuclear Code Case N-201 to Accommodate the Needs of Metallic Core Support Structures for High Temperature Gas Cooled Reactors Currently in Development

    SciTech Connect

    Mit Basol; John F. Kielb; John F. MuHooly; Kobus Smit

    2007-05-02

    On September 29, 2005, ASME Standards Technology, LLC (ASME ST-LLC) executed a multi-year, cooperative agreement with the United States DOE for the Generation IV Reactor Materials project. The project's objective is to update and expand appropriate materials, construction, and design codes for application in future Generation IV nuclear reactor systems that operate at elevated temperatures. Task 4 was embarked upon in recognition of the large quantity of ongoing reactor designs utilizing high temperature technology. Since Code Case N-201 had not seen a significant revision (except for a minor revision in September, 2006 to change the SA-336 forging reference for 304SS and 316SS to SA-965 in Tables 1.2(a) and 1.2(b), and some minor editorial changes) since December 1994, identifying recommended updates to support the current high temperature Core Support Structure (CSS) designs and potential new designs was important. As anticipated, the Task 4 effort identified a number of Code Case N-201 issues. Items requiring further consideration range from addressing apparent inconsistencies in definitions and certain material properties between CC-N-201 and Subsection NH, to inclusion of additional materials to provide the designer more flexibility of design. Task 4 developed a design parameter survey that requested input from the CSS designers of ongoing high temperature gas cooled reactor metallic core support designs. The responses to the survey provided Task 4 valuable input to identify the design operating parameters and future needs of the CSS designers. Types of materials, metal temperature, time of exposure, design pressure, design life, and fluence levels were included in the Task 4 survey responses. The results of the survey are included in this report. This research proves that additional work must be done to update Code Case N-201. Task 4 activities provide the framework for the Code Case N-201 update and future work to provide input on materials. Candidate

  1. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine

    PubMed Central

    Brierley, Joe; Carcillo, Joseph A.; Choong, Karen; Cornell, Tim; DeCaen, Allan; Deymann, Andreas; Doctor, Allan; Davis, Alan; Duff, John; Dugas, Marc-Andre; Duncan, Alan; Evans, Barry; Feldman, Jonathan; Felmet, Kathryn; Fisher, Gene; Frankel, Lorry; Jeffries, Howard; Greenwald, Bruce; Gutierrez, Juan; Hall, Mark; Han, Yong Y.; Hanson, James; Hazelzet, Jan; Hernan, Lynn; Kiff, Jane; Kissoon, Niranjan; Kon, Alexander; Irazusta, Jose; Lin, John; Lorts, Angie; Mariscalco, Michelle; Mehta, Renuka; Nadel, Simon; Nguyen, Trung; Nicholson, Carol; Peters, Mark; Okhuysen-Cawley, Regina; Poulton, Tom; Relves, Monica; Rodriguez, Agustin; Rozenfeld, Ranna; Schnitzler, Eduardo; Shanley, Tom; Skache, Sara; Skippen, Peter; Torres, Adalberto; von Dessauer, Bettina; Weingarten, Jacki; Yeh, Timothy; Zaritsky, Arno; Stojadinovic, Bonnie; Zimmerman, Jerry; Zuckerberg, Aaron

    2013-01-01

    Background The Institute of Medicine calls for the use of clinical guidelines and practice parameters to promote “best practices” and to improve patient outcomes. Objective 2007 update of the 2002 American College of Critical Care Medicine Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock. Participants Society of Critical Care Medicine members with special interest in neonatal and pediatric septic shock were identified from general solicitation at the Society of Critical Care Medicine Educational and Scientific Symposia (2001–2006). Methods The Pubmed/MEDLINE literature database (1966–2006) was searched using the keywords and phrases: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation (ECMO), and American College of Critical Care Medicine guidelines. Best practice centers that reported best outcomes were identified and their practices examined as models of care. Using a modified Delphi method, 30 experts graded new literature. Over 30 additional experts then reviewed the updated recommendations. The document was subsequently modified until there was greater than 90% expert consensus. Results The 2002 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and AHA sanctioned recommendations. Centers that implemented the 2002 guidelines reported best practice outcomes (hospital mortality 1%–3% in previously healthy, and 7%– 10% in chronically ill children). Early use of 2002 guidelines was associated with improved outcome in the community hospital emergency department (number needed to treat = 3.3) and tertiary pediatric intensive care setting (number needed to treat = 3.6); every hour that went by without guideline adherence was associated with a 1.4-fold increased mortality risk. The updated 2007 guidelines continue to recognize an increased likelihood that

  2. Frequent Itemset Hiding Algorithm Using Frequent Pattern Tree Approach

    ERIC Educational Resources Information Center

    Alnatsheh, Rami

    2012-01-01

    A problem that has been the focus of much recent research in privacy preserving data-mining is the frequent itemset hiding (FIH) problem. Identifying itemsets that appear together frequently in customer transactions is a common task in association rule mining. Organizations that share data with business partners may consider some of the frequent…

  3. Treatment of Anthrax Disease Frequently Asked Questions

    SciTech Connect

    Judd, Kathleen S.; Young, Joan E.; Lesperance, Ann M.; Malone, John D.

    2010-05-14

    This document provides a summary of Frequently Asked Questions (FAQs) on the treatment of anthrax disease caused by a wide-area release of Bacillus anthracis spores as an act bioterrorism. These FAQs are intended to provide the public health and medical community, as well as others, with guidance and communications to support the response and long-term recovery from an anthrax event.

  4. Winter Weather Frequently Asked Questions

    MedlinePlus

    ... Planning Information on Specific Types of Emergencies Winter Weather Frequently Asked Questions Language: English Español (Spanish) Recommend ... I do if I get stranded in cold weather? Tie a brightly colored cloth to the antenna ...

  5. National Study of Student Support Services. Third-Year Longitudinal Study Results and Program Implementation Study Update.

    ERIC Educational Resources Information Center

    Chaney, Bradford; Muraskin, Lana; Cahalan, Margaret; Rak, Rebecca

    This follow-up study, part of the National Study of Student Support Services compared the status of 2,900 disadvantaged students receiving student support services (SSS) since entering college 3 years earlier and 2,900 nonparticipating comparable students. Services offered varied among institutions but were all intended to help students stay in…

  6. Effect of the tobacco price support program on cigarette consumption in the United States: an updated model.

    PubMed Central

    Zhang, P; Husten, C; Giovino, G

    2000-01-01

    OBJECTIVES: This study evaluated the direct effect of the tobacco price support program on domestic cigarette consumption. METHODS: We developed an economic model of demand and supply of US tobacco to estimate how much the price support program increases the price of tobacco. We calculated the resultant increase in cigarette prices from the change in the tobacco price and the quantity of domestic tobacco contained in US cigarettes. We then assessed the reduction in cigarette consumption attributable to the price support program by applying the estimated increase in the cigarette price to assumed price elasticities of demand for cigarettes. RESULTS: We estimated that the tobacco price support program increased the price of tobacco leaf by $0.36 per pound. This higher tobacco price translates to a $0.01 increase in the price of a pack of cigarettes and an estimated 0.21% reduction in cigarette consumption. CONCLUSION: Because the tobacco price support program increases the price of cigarettes minimally, its potential health benefit is likely to be small. The adverse political effect of the tobacco program might substantially outweigh the potential direct benefit of the program on cigarette consumption. PMID:10800423

  7. The UCSC Genome Browser database: 2016 update.

    PubMed

    Speir, Matthew L; Zweig, Ann S; Rosenbloom, Kate R; Raney, Brian J; Paten, Benedict; Nejad, Parisa; Lee, Brian T; Learned, Katrina; Karolchik, Donna; Hinrichs, Angie S; Heitner, Steve; Harte, Rachel A; Haeussler, Maximilian; Guruvadoo, Luvina; Fujita, Pauline A; Eisenhart, Christopher; Diekhans, Mark; Clawson, Hiram; Casper, Jonathan; Barber, Galt P; Haussler, David; Kuhn, Robert M; Kent, W James

    2016-01-01

    For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the "Data Integrator", for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment. PMID:26590259

  8. The UCSC Genome Browser database: 2016 update

    PubMed Central

    Speir, Matthew L.; Zweig, Ann S.; Rosenbloom, Kate R.; Raney, Brian J.; Paten, Benedict; Nejad, Parisa; Lee, Brian T.; Learned, Katrina; Karolchik, Donna; Hinrichs, Angie S.; Heitner, Steve; Harte, Rachel A.; Haeussler, Maximilian; Guruvadoo, Luvina; Fujita, Pauline A.; Eisenhart, Christopher; Diekhans, Mark; Clawson, Hiram; Casper, Jonathan; Barber, Galt P.; Haussler, David; Kuhn, Robert M.; Kent, W. James

    2016-01-01

    For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the “Data Integrator”, for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment. PMID:26590259

  9. IMPACTING POPULATION CARDIOVASCULAR HEALTH THROUGH A COMMUNITY-BASED PRACTICE NETWORK: UPDATE ON AN ASH-SUPPORTED COLLABORATIVE

    PubMed Central

    Egan, Brent M.; Laken, Marilyn A.; Wagner, C. Shaun; Mack, Sheryl S.; Seymour-Edwards, Kim; Dodson, John; Zhao, Yumin; Lackland, Daniel T.

    2011-01-01

    The Hypertension Initiative began in 1999 to help transition South Carolina from a leader in cardiovascular disease (CVD) to a model of heart and vascular health. Goals were to reduce heart disease and stroke 50% by promoting healthy lifestyles and access to effective care and medications. Continuing medical education was used to train providers, encourage physicians to become American Society of Hypertension (ASH) certified Hypertension Specialists and recruit practices into the community-based practice network (CBPN). Practice data audit with provider specific feedback is a key quality improvement tool. With ASH support, the CBPN has grown to 197 practices with ~1.6 million patients (~700,000 hypertensives). Clinical data are obtained from electronic health records and quarterly provider feedback reports generated. Hypertension, hypercholesterolemia and diabetes control rose and South Carolina improved from 51st to 35th in CVD mortality from 1995 to 2006. The Hypertension Initiative expanded to the Outpatient Quality Improvement Network to encompass comparative effectiveness research and other chronic diseases. Lessons learned include: trust enables success, addressing practice priorities powers participation, infrastructure support must be multilateral, strategic planning identifies opportunities and pitfalls. A collaborative practice network is attainable that produces positive, sustainable, and growing impacts on cardiovascular and other chronic diseases. PMID:21806763

  10. SEI: An update

    NASA Technical Reports Server (NTRS)

    Peach, Lewis L., Jr.

    1991-01-01

    An update on the Space Exploration Initiative (SEI) is given in viewgraph form. Topics covered include the key prerequisites of human exploration, project planning, Mars and lunar explorations, supporting technologies, near-term strategies for SEI, human support elements, and Space Station Freedom SEI accommodations.

  11. Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

    PubMed

    Kavlock, Robert; Chandler, Kelly; Houck, Keith; Hunter, Sid; Judson, Richard; Kleinstreuer, Nicole; Knudsen, Thomas; Martin, Matt; Padilla, Stephanie; Reif, David; Richard, Ann; Rotroff, Daniel; Sipes, Nisha; Dix, David

    2012-07-16

    The field of toxicology is on the cusp of a major transformation in how the safety and hazard of chemicals are evaluated for potential effects on human health and the environment. Brought on by the recognition of the limitations of the current paradigm in terms of cost, time, and throughput, combined with the ever increasing power of modern biological tools to probe mechanisms of chemical-biological interactions at finer and finer resolutions, 21st century toxicology is rapidly taking shape. A key element of the new approach is a focus on the molecular and cellular pathways that are the targets of chemical interactions. By understanding toxicity in this manner, we begin to learn how chemicals cause toxicity, as opposed to merely what diseases or health effects they might cause. This deeper understanding leads to increasing confidence in identifying which populations might be at risk, significant susceptibility factors, and key influences on the shape of the dose-response curve. The U. S. Environmental Protection Agency (EPA) initiated the ToxCast, or "toxicity forecaster", program 5 years ago to gain understanding of the strengths and limitations of the new approach by starting to test relatively large numbers (hundreds) of chemicals against an equally large number of biological assays. Using computational approaches, the EPA is building decision support tools based on ToxCast in vitro screening results to help prioritize chemicals for further investigation, as well as developing predictive models for a number of health outcomes. This perspective provides a summary of the initial, proof of concept, Phase I of ToxCast that has laid the groundwork for the next phases and future directions of the program. PMID:22519603

  12. On Differentially Private Frequent Itemset Mining.

    PubMed

    Zeng, Chen; Naughton, Jeffrey F; Cai, Jin-Yi

    2012-11-01

    We consider differentially private frequent itemset mining. We begin by exploring the theoretical difficulty of simultaneously providing good utility and good privacy in this task. While our analysis proves that in general this is very difficult, it leaves a glimmer of hope in that our proof of difficulty relies on the existence of long transactions (that is, transactions containing many items). Accordingly, we investigate an approach that begins by truncating long transactions, trading off errors introduced by the truncation with those introduced by the noise added to guarantee privacy. Experimental results over standard benchmark databases show that truncating is indeed effective. Our algorithm solves the "classical" frequent itemset mining problem, in which the goal is to find all itemsets whose support exceeds a threshold. Related work has proposed differentially private algorithms for the top-k itemset mining problem ("find the k most frequent itemsets".) An experimental comparison with those algorithms show that our algorithm achieves better F-score unless k is small. PMID:24039383

  13. [Osmolality of frequently consumed beverages].

    PubMed

    Dini, Elizabeth; De Abreu, Jorge; López, Emeris

    2004-12-01

    The objective of this work was to determine the osmolality of beverages frequently consumed by children and adolescents due to the scarce information available in our country. The samples were grouped as follows: milks; refreshments; beverages based on fruits, vegetables, cereals, and tubers; sport drinks; energizing drinks; oral rehydrating solutions; reconstituted drinks and infusions. A vapor pressure digital osmometer was used, five samples of each beverage from different lots were analyzed. Four osmolality determinations were made on each sample and the average of such values was calculated. When the variation coefficient of the osmolality measurements of the five samples was higher than 10%, five additional samples were analyzed. As many samples as possible were used with breast milk in the time period of the study. Osmolality averages, standard deviation, and the osmolality confidence intervals (95% reliability) were calculated. The osmolality (mmol/kg) of breast milk and that of cow milk were between 273 and 389; refreshments, white, black and flavored colas, and malts ranged between 479-811; and soda and light drinks: 44-62; fresh fruit and commercial drinks (coconut, peach, apple, orange, pear, pineapple, grape, plum, tamarind): 257-1152 and light juices: 274; sports beverages: 367; energizing drinks: 740; drinks based on vegetables and cereals: 213-516; oral rehydrating solutions: 236-397; reconstituted drinks: 145; infusions: 25. Beverages with adequate osmolality levels for children were: milks, light refreshments, soda, fresh and light juices, oral rehydrating, soy, and reconstituted drinks and infusions. PMID:15602899

  14. Frequent Hemodialysis Fistula Infectious Complications

    PubMed Central

    Lok, Charmaine E.; Sontrop, Jessica M.; Faratro, Rose; Chan, Christopher T.; Zimmerman, Deborah Lynn

    2014-01-01

    Background Few studies have examined if infectious arteriovenous access complications vary with the cannulation technique and whether this is modified by dialysis frequency. We compared the infection rate between fistulas cannulated using buttonhole versus stepladder techniques for patients treated with short daily (SDH) or nocturnal hemodialysis at home (NHD). We also compared patients receiving conventional intermittent hemodialysis (CIHD) using stepladder cannulation. Methods Data were prospectively collected from 631 patients dialyzed with a fistula from 2001 to 2010 (Toronto and Ottawa, Canada). We compared the person-time incidence rate of bacteremia and local fistula infections using the exact binomial test. Results Forty-six (7.3%) patients received SDH (≥5 sessions/week, 2-4 h/session), 128 (20.3%) NHD (≥4 sessions/week, ≥5 h/session) and 457 (72%) CIHD (3 sessions/week, ≤4 h/session). Fifty percent of SDH and 72% of NHD patients used the buttonhole technique. There were 39 buttonhole-related bacteremias (rate: 0.196/1,000 fistula days) and at least 2 local buttonhole site infections. Staphylococcus aureus accounted for 85% of the bacteremias. There were 5 (13%) infection-related hospitalizations and 3 (10%) serious metastatic infections, including fistula loss. In comparison, there was 1 possible fistula-related infection in CIHD during follow-up (rate: 0.002/1,000 fistula days). Conclusions The rate of buttonhole-related infections was high among patients on frequent hemodialysis and more than 50 times greater than that among patients on CIHD with the stepladder technique. Most bacteremias were due to S. aureus – with serious consequences. The risks and benefits of buttonhole cannulation require individual consideration with careful monitoring, prophylaxis and management. PMID:25473405

  15. Email Updates

    MedlinePlus

    ... unsubscribe. Prevent MedlinePlus emails from being marked as "spam" or "junk" To ensure that MedlinePlus email updates ... com to your email address book, adjust your spam settings, or follow the instructions from your email ...

  16. Focus Group Study Exploring Factors Related to Frequent Sickness Absence

    PubMed Central

    van Rhenen, Willem

    2016-01-01

    Introduction Research investigating frequent sickness absence (3 or more episodes per year) is scarce and qualitative research from the perspective of frequent absentees themselves is lacking. The aim of the current study is to explore awareness, determinants of and solutions to frequent sickness absence from the perspective of frequent absentees themselves. Methods We performed a qualitative study of 3 focus group discussions involving a total of 15 frequent absentees. Focus group discussions were audiotaped and transcribed verbatim. Results were analyzed with the Graneheim method using the Job Demands Resources (JD–R) model as theoretical framework. Results Many participants were not aware of their frequent sickness absence and the risk of future long-term sickness absence. As determinants, participants mentioned job demands, job resources, home demands, poor health, chronic illness, unhealthy lifestyles, and diminished feeling of responsibility to attend work in cases of low job resources. Managing these factors and improving communication (skills) were regarded as solutions to reduce frequent sickness absence. Conclusions The JD–R model provided a framework for determinants of and solutions to frequent sickness absence. Additional determinants were poor health, chronic illness, unhealthy lifestyles, and diminished feeling of responsibility to attend work in cases of low job resources. Frequent sickness absence should be regarded as a signal that something is wrong. Managers, supervisors, and occupational health care providers should advise and support frequent absentees to accommodate job demands, increase both job and personal resources, and improve health rather than express disapproval of frequent sickness absence and apply pressure regarding work attendance. PMID:26872050

  17. Frequent Subgraph Discovery in Large Attributed Streaming Graphs

    SciTech Connect

    Ray, Abhik; Holder, Larry; Choudhury, Sutanay

    2014-08-13

    The problem of finding frequent subgraphs in large dynamic graphs has so far only consid- ered a dynamic graph as being represented by a series of static snapshots taken at various points in time. This representation of a dynamic graph does not lend itself well to real time processing of real world graphs like social networks or internet traffic which consist of a stream of nodes and edges. In this paper we propose an algorithm that discovers the frequent subgraphs present in a graph represented by a stream of labeled nodes and edges. Our algorithm is efficient and consists of tunable parameters that can be tuned by the user to get interesting patterns from various kinds of graph data. In our model updates to the graph arrive in the form of batches which contain new nodes and edges. Our algorithm con- tinuously reports the frequent subgraphs that are estimated to be found in the entire graph as each batch arrives. We evaluate our system using 5 large dynamic graph datasets: the Hetrec 2011 challenge data, Twitter, DBLP and two synthetic. We evaluate our approach against two popular large graph miners, i.e., SUBDUE and GERM. Our experimental re- sults show that we can find the same frequent subgraphs as a non-incremental approach applied to snapshot graphs, and in less time.

  18. Working Memory Updating as a Predictor of Academic Attainment

    ERIC Educational Resources Information Center

    Lechuga, M. Teresa; Pelegrina, Santiago; Pelaez, Jose L.; Martin-Puga, M. Eva; Justicia, M. Jose

    2016-01-01

    There is growing evidence supporting the importance of executive functions, and specifically working memory updating (WMU), for children's academic achievement. This study aimed to assess the specific contribution of updating to the prediction of academic performance. Two updating tasks, which included different updating components, were…

  19. NLM extramural program: frequently asked questions.

    PubMed Central

    Zink, S; Illes, J; Vannier, M W

    1996-01-01

    New and aspiring investigators often ask the same questions of experts as proposals are formulated, written, and submitted to the National Library of Medicine (NLM) for peer review. The NLM's Division of Extramural Programs (EP) provides support to medical libraries, academic medical centers, individuals, and industry through numerous types of grants and contracts. A complex set of processes and procedures is in place and is familiar to established and funded researchers, but to few others. A collection of frequently asked questions (FAQ) and their answers on these issues has been prepared by the Biomedical Library Review Committee (BLRC), a standing advisory group to the NLM that meets three times a year to review and score proposals. The BLRC and two experts on National Institutes of Health (NIH) grants and contracts compiled their advice in an electronic FAQ that has been edited and abridged as an introduction to NLM EP for investigators from medical library science, informatics, and biotechnology. The BLRC expects that if new investigators are able to avoid common mistakes and misconceptions, their proposals will improve in quality and they will be able to spend their time more effectively in proposal preparation. Images PMID:8826620

  20. Response of Sensitive Behaviors to Frequent Measurement

    PubMed Central

    2014-01-01

    We study the influence of frequent survey measurement on behavior. Widespread access to the Internet has made important breakthroughs in frequent measurement possible—potentially revolutionizing social science measurement of processes that change quickly over time. One key concern about using such frequent measurement is that it may influence the behavior being studied. We investigate this possibility using both a population-based experiment with random assignment to participation in a weekly journal for twelve months (versus no journal) and a large scale population-based journal-keeping study with weekly measurement for 30 months. Results reveal few of the measured behaviors are correlated with assignment to frequent measurement. Theoretical reasoning regarding the likely behavioral response to frequent measurement correctly predicts domains most vulnerable to this possibility. Overall, however, we found little evidence of behavioral response to frequent measurement. PMID:25432599

  1. Plus updates.

    PubMed

    Parkhouse, Richard C

    2008-01-01

    Inevitably, with an innovative and fast growing technique, improvements in hardware and refinements are ongoing. So it is with Plus. Therefore there are some relevant updates, subsequent to my article "Current Products and Practice: Tip-Edge Plus" (reprinted in the last issue of International Journalof Orthodontics by kind permission of the British Journal of Orthodontics). PMID:19263632

  2. Update '98.

    ERIC Educational Resources Information Center

    Mock, Karen R.

    1998-01-01

    Updates cases and issues previously discussed in this regular column on human rights in Canada, including racism and anti-Semitism, laws on hate crimes, hate sites on the World Wide Web, the use of the "free speech" defense by hate groups, and legal challenges to antiracist groups by individuals criticized by them. (DSK)

  3. Memory Updating and Mental Arithmetic

    PubMed Central

    Han, Cheng-Ching; Yang, Tsung-Han; Lin, Chia-Yuan; Yen, Nai-Shing

    2016-01-01

    Is domain-general memory updating ability predictive of calculation skills or are such skills better predicted by the capacity for updating specifically numerical information? Here, we used multidigit mental multiplication (MMM) as a measure for calculating skill as this operation requires the accurate maintenance and updating of information in addition to skills needed for arithmetic more generally. In Experiment 1, we found that only individual differences with regard to a task updating numerical information following addition (MUcalc) could predict the performance of MMM, perhaps owing to common elements between the task and MMM. In Experiment 2, new updating tasks were designed to clarify this: a spatial updating task with no numbers, a numerical task with no calculation, and a word task. The results showed that both MUcalc and the spatial task were able to predict the performance of MMM but only with the more difficult problems, while other updating tasks did not predict performance. It is concluded that relevant processes involved in updating the contents of working memory support mental arithmetic in adults. PMID:26869971

  4. [DGRW-update: patient education].

    PubMed

    Faller, H; Reusch, A; Meng, K

    2011-10-01

    Patient education programmes, i. e. standardized, manualized, interactive group programmes aiming to increase self-management and empowerment, are a core element of medical rehabilitation for chronic conditions. In an update of the evidence of the effectiveness of patient education, its effectiveness was proven for a broad spectrum of chronic disorders, such as diabetes mellitus, chronic low back pain, rheumatoid arthritis, coronary heart disease, chronic heart failure, bronchial asthma, COPD, and cancer, as well as for the modification of health behaviours, such as diet and exercise. To sustain effects, aftercare interventions, such as support provided by phone, were found to be successful. Interventions targeted to particular patient groups according to gender, age, or migration background are also being developed more frequently. When evaluating educational interventions not only distal outcomes, such as quality of life and participation, should be used but also proximal outcomes such as self-management skills. A recent survey of patient education practice in medical rehabilitation revealed a continuing potential for optimization relative to manualization, evaluation and didactics. However, the dissemination of innovative programmes into rehabilitation routine presents a major challenge. PMID:21976261

  5. Ten Frequent Assumptions of Cultural Bias in Counseling.

    ERIC Educational Resources Information Center

    Pedersen, Paul

    1987-01-01

    Identifies 10 of the most frequently encountered examples of cultural bias that consistently emerge in the literature about multicultural counseling and development. Assumptions are described in the areas of normal behavior, individualism, limits of academic disciplines, dependence on abstract words, independence, client support systems, linear…

  6. 75 FR 31794 - Information Sheet Guidance for Sponsors, Clinical Investigators, and IRBs; Frequently Asked...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... FR 5861), which describes FDA's intention to update the process for developing, issuing, and making... Guidances as needed. In the Federal Register of July 29, 2008 (73 FR 43940), FDA announced the availability... Investigators, and IRBs; Frequently Asked Questions--Statement of Investigator (Form FDA 1572);...

  7. Recent advances in emergency life support.

    PubMed

    Dries, David J; Sample, Mary Anne

    2002-03-01

    With additional international input, recent changes in emergency life support are reflected in updated guidelines for Advanced Cardiac Life Support (ACLS) from the American Heart Association and new technology in the arena of vascular access and emergency airway management. These changes will expand nurses' ability to provide advanced levels of care, even in the prehospital situation, and represent a more rigorous evidence-based approach than ever before. As early morbidity and mortality in emergency situations are frequently associated with complications associated with airway management and vascular access, recent development in these areas are reviewed along with evolution in ACLS guidelines. PMID:11818257

  8. Frequently Asked Questions about Digital Mammography

    MedlinePlus

    ... Consumer Information (MQSA) Frequently Asked Questions About Digital Mammography Share Tweet Linkedin Pin it More sharing options ... mammography exams, such as DBT? What is digital mammography? Full field digital mammography (FFDM, also known simply ...

  9. Frequently Asked Questions (Palliative Care: Conversations Matter)

    MedlinePlus

    ... Questions Frequently Asked Questions: What is pediatric palliative care? Pediatric palliative (pal-lee-uh-tiv) care is ... for patients and families. Who provides pediatric palliative care? Every palliative care team is different. The team ...

  10. Head Lice: Frequently Asked Questions (FAQs)

    MedlinePlus

    ... Treatment FAQs Malathion FAQs Epidemiology & Risk Factors Disease Biology Diagnosis Treatment Prevention & Control Resources for Health Professionals ... Frequently Asked Questions (FAQs) Epidemiology & Risk Factors Disease Biology Diagnosis Treatment Prevention & Control Resources for Health Professionals ...

  11. Head Lice: Treatment Frequently Asked Questions (FAQs)

    MedlinePlus

    ... Treatment FAQs Malathion FAQs Epidemiology & Risk Factors Disease Biology Diagnosis Treatment Prevention & Control Resources for Health Professionals ... Frequently Asked Questions (FAQs) Epidemiology & Risk Factors Disease Biology Diagnosis Treatment Prevention & Control Resources for Health Professionals ...

  12. Body Lice Frequently Asked Questions (FAQs)

    MedlinePlus

    ... Treatment FAQs Malathion FAQs Epidemiology & Risk Factors Disease Biology Diagnosis Treatment Prevention & Control Resources for Health Professionals ... Frequently Asked Questions (FAQs) Epidemiology & Risk Factors Disease Biology Diagnosis Treatment Prevention & Control Resources for Health Professionals ...

  13. Frequently Asked Questions about Genetic Disorders

    MedlinePlus

    ... used on this page Frequently Asked Questions About Genetic Disorders What are genetic disorders? A genetic disorder is a disease caused ... significant risk of developing the disease. . Geneticists group genetic disorders into three categories: Monogenetic disorders are caused ...

  14. Frequently Asked Questions about Genetic Testing

    MedlinePlus

    ... sobre las pruebas genéticas Frequently Asked Questions About Genetic Testing What is genetic testing? What can I ... find more information about genetic testing? What is genetic testing? Genetic testing uses laboratory methods to look ...

  15. Frequent patterns mining in multiple biological sequences.

    PubMed

    Chen, Ling; Liu, Wei

    2013-10-01

    Existing algorithms for mining frequent patterns in multiple biosequences may generate multiple projected databases and short candidate patterns, which can increase computation time and memory requirement. In order to overcome such shortcomings, we propose a fast and efficient algorithm for mining frequent patterns in multiple biological sequences (MSPM). We first present the concept of a primary pattern, which can be extended to form larger patterns in the sequence. To detect frequent primary patterns, a prefix tree is constructed. Based on this prefix tree, a pattern-extending approach is also presented to mine frequent patterns without producing a large number of irrelevant candidate patterns. The experimental results show that the MSPM algorithm can achieve not only faster speed, but also higher quality results as compared with other methods. PMID:24034736

  16. Women and Diabetes: Frequently Asked Questions

    MedlinePlus

    ... A A A Listen En Español Women and Diabetes: Frequently Asked Questions Why are women with diabetes ... 08-book-sabores-de-cuba.html More from diabetes.org Shopdiabetes.org: Take the Guesswork out of ...

  17. Levetiracetam: Probably Associated Diurnal Frequent Urination.

    PubMed

    Ju, Jun; Zou, Li-Ping; Shi, Xiu-Yu; Hu, Lin-Yan; Pang, Ling-Yu

    2016-01-01

    Diurnal frequent urination is a common condition in elementary school children who are especially at risk for associated somatic and behavioral problems. Levetiracetam (LEV) is a broad-spectrum antiepileptic drug that has been used in both partial and generalized seizures and less commonly adverse effects including psychiatric and behavioral problems. Diurnal frequent urination is not a well-known adverse effect of LEV. Here, we reported 2 pediatric cases with epilepsy that developed diurnal frequent urination after LEV administration. Case 1 was a 6-year-old male patient who presented urinary frequency and urgency in the daytime since the third day after LEV was given as adjunctive therapy. Symptoms increased accompanied by the raised dosage of LEV. Laboratory tests and auxiliary examinations did not found evidence of organic disease. Diurnal frequent urination due to LEV was suspected, and then the drug was discontinued. As expected, his frequency of urination returned to normal levels. Another 13-year-old female patient got similar clinical manifestations after oral LEV monotherapy and the symptoms became aggravated while in stress state. Since the most common causes of frequent micturition had been ruled out, the patient was considered to be diagnosed with LEV-associated psychogenic frequent urination. The dosage of LEV was reduced to one-third, and the frequency of urination was reduced by 60%. Both patients got the Naranjo score of 6, which indicated that LEV was a "probable" cause of diurnal frequent urination. Although a definite causal link between LEV and diurnal urinary frequency in the 2 cases remains to be established, we argue that diurnal frequent urination associated with LEV deserves clinician's attention. PMID:26938751

  18. Atypical odontalgia--an update.

    PubMed

    Patel, Seena B; Boros, Audrey L; Kumar, Satish K S

    2012-09-01

    Atypical odontalgia is a commonly misdiagnosed condition that frequently leads to unnecessary dental treatments such as extraction and endodontic therapy. These treatments often worsen the pain. Despite greater recognition and understanding of this condition, proper diagnosis and treatment remains a challenge. It is believed that atypical odontalgia is a neuropathic condition. This article updates the current understanding of the etiology and pathophysiology of atypical odontalgia, and provides appropriate diagnostic and management approaches for this condition. PMID:23097829

  19. Rhabdomyolysis updated

    PubMed Central

    Efstratiadis, G; Voulgaridou, A; Nikiforou, D; Kyventidis, A; Kourkouni, E; Vergoulas, G

    2007-01-01

    Rhabdomyolysis constitutes a common cause of acute renal failure and presents paramount interest. A large variety of causes with different pathogenetic mechanisms can involve skeletal muscles resulting in rhabdomyolysis with or without acute renal failure. Crush syndrome, one of the most common causes of rhabdomyolysis presents increased clinical interest, particularly in areas often involved by earthquakes, such as Greece and Turkey. Drug abusers are another sensitive group of young patients prone to rhabdomyolysis, which attracts the clinical interest of a variety of medical specialties. We herein review the evidence extracted from updated literature concerning the data related to pathogenetic mechanisms and pathophysiology as well as the management of this interesting syndrome. PMID:19582207

  20. [Pharmacovigilance update].

    PubMed

    Livio, F

    2013-01-01

    Main pharmacovigilance updates in 2012 are reviewed here. Dabigatran: elderly patients with renal failure are at higher risk of bleeding. Dual renin-angiotensin-aldosterone system blockade comprising aliskiren is harmful. Incretins: low risk of acute pancreatitis. Interaction between fusidic acid and statins: many reports of rhabdomyolysis. Interactions between boceprevir/telaprevir and antiretroviral therapies: complex, but manageable. Citalopram, ondansetron: maximum recommended doses are reduced. Atomoxetine: significant increase in blood pressure and heart rate in a fraction of exposed patients. Agomelatine: elevated liver enzymes are common. Fingolimod: bradycardia and heart blocks after first dose - stronger safety recommendations regarding use in patients with heart conditions and strengthened cardiovascular monitoring. PMID:23367709

  1. [Pharmacovigilance update].

    PubMed

    Fogarasi Szabo, Nathalie; Diezi, Léonore; Delenclos, Laurie; Renard, Delphine; Chtioui, Haithem; Rothuizen, Laura E; Buclin, Thierry; Livio, Françoise

    2015-01-14

    The main pharmacovigilance updates in 2014 are reviewed. Ivabradine: increased risk of cardiovascular death and myocardial infarction in patients with symptomatic angina treated with high dosages. Clopidogrel: rare observations of acquired hemophilia. Orlistat: may reduce the absorption of HIV antiretrovirals. Ponatinib: increased risk of arteriopathy and thrombosis. Axitinib: significant risk of heart failure (class effect). Tocilizumab: possible causal relationship with the emergence or aggravation of psoriasis. Lithium: hypercalcemia and hyperparathyroidism commonly observed. Sildenalfil: suspected causal association with melanoma, so far not proven, Methylphenidate: rare observations of priapism. St John's wort (Hypericum): reduced effectiveness of hormonal contraceptives, including implants. PMID:25799668

  2. [Pharmacovigilance update].

    PubMed

    Dao, Kim; Chtioui, Haithem; Rothuizen, Laura E; Diezi, Léonore; Prod'hom, Sylvain; Winterfeld, Ursula; Buclin, Thierry; Livio, Françoise

    2016-01-13

    The main pharmacovigilance updates in 2015are reviewed. Sofosbuvir amiodarone interaction: risk of severe bradycardia. Dasabuvir clopidogrel interaction: increased dasabuvir concentrations and potential risk of QTprolongation. SGLT2 inhibitors: risks of diabetic acidocetosis and bone fracture. Dabigatran: therapeutic drug monitoring may improve benefit-risk ratio. Ibuprofen: at higher dosage, vascular risks are comparable to coxibs. Pregabaline, gabapentine: potential for abuse and addiction. Varenicline: potentiates alcohol's effects. Codeine: contra-indicated as cough medicine under the age of twelve. Valproate: strengthened warnings on the risks of valproate use in pregnancy. Dimethylfumarate: rare observations of progressive multifocal leucoencephalopathy. Ustekinumab: rare observations of erythrodermia. PMID:26946710

  3. Human strategy updating in evolutionary games.

    PubMed

    Traulsen, Arne; Semmann, Dirk; Sommerfeld, Ralf D; Krambeck, Hans-Jürgen; Milinski, Manfred

    2010-02-16

    Evolutionary game dynamics describe not only frequency-dependent genetic evolution, but also cultural evolution in humans. In this context, successful strategies spread by imitation. It has been shown that the details of strategy update rules can have a crucial impact on evolutionary dynamics in theoretical models and, for example, can significantly alter the level of cooperation in social dilemmas. What kind of strategy update rules can describe imitation dynamics in humans? Here, we present a way to measure such strategy update rules in a behavioral experiment. We use a setting in which individuals are virtually arranged on a spatial lattice. This produces a large number of different strategic situations from which we can assess strategy updating. Most importantly, spontaneous strategy changes corresponding to mutations or exploration behavior are more frequent than assumed in many models. Our experimental approach to measure properties of the update mechanisms used in theoretical models will be useful for mathematical models of cultural evolution. PMID:20142470

  4. RESRAD update

    SciTech Connect

    Yu, C.; Cheng, J.J.; Zielen, A.J.; Jones, L.G.; LePoire, D.J.; Wang, Y.Y. ); Yuan, Y.C. ); Loureiro, C.O. . Escola de Engenharia); Wallo, A. III; Peterson, H. . Offic

    1993-01-01

    A microcomputer program called RESRAD, which implements a pathway analysis method for radiological risk assessment, was developed by Argonne National Laboratory (ANL) in 1989. This program is used to derive allowable residual concentrations of radionuclides in soil and to predict effective dose equivalents and excess cancer incidence risks incurred by an individual exposed to radioactive materials. Since its development, the RESRAD code has been adopted by DOE in Order 5400.5 for the derivation of soil cleanup criteria and dose calculations, and it has been used widely by DOE, other agencies, and their contractors. The original models used by ANL to develop RESRAD were initially developed as part of a DOE effort that began in the early 1980s and involved most of the national laboratories and DOE program offices. The RESRAD code is continuously improved and updated to incorporate comments from users and new features that ease the interaction with users and increase the code's capability and flexibility. The DOE Offices of Environmental Guidance and Environmental Restoration also provide periodic guidance regarding any significant changes to the code. The RESRAD update, Version 5.0, has substantial improvements in many aspects compared with the last version released in 1989.

  5. RESRAD update

    SciTech Connect

    Yu, C.; Cheng, J.J.; Zielen, A.J.; Jones, L.G.; LePoire, D.J.; Wang, Y.Y.; Yuan, Y.C.; Loureiro, C.O.; Wallo, A. III; Peterson, H.; H Williams, W.A.

    1993-05-01

    A microcomputer program called RESRAD, which implements a pathway analysis method for radiological risk assessment, was developed by Argonne National Laboratory (ANL) in 1989. This program is used to derive allowable residual concentrations of radionuclides in soil and to predict effective dose equivalents and excess cancer incidence risks incurred by an individual exposed to radioactive materials. Since its development, the RESRAD code has been adopted by DOE in Order 5400.5 for the derivation of soil cleanup criteria and dose calculations, and it has been used widely by DOE, other agencies, and their contractors. The original models used by ANL to develop RESRAD were initially developed as part of a DOE effort that began in the early 1980s and involved most of the national laboratories and DOE program offices. The RESRAD code is continuously improved and updated to incorporate comments from users and new features that ease the interaction with users and increase the code`s capability and flexibility. The DOE Offices of Environmental Guidance and Environmental Restoration also provide periodic guidance regarding any significant changes to the code. The RESRAD update, Version 5.0, has substantial improvements in many aspects compared with the last version released in 1989.

  6. Fathers Can Support Breastfeeding

    MedlinePlus

    ... System Women, Infants and Children (WIC) Fathers Supporting Breastfeeding Last Published: 05/26/2016 Email Updates Click ... in each of the materials. FATHERS CAN SUPPORT BREASTFEEDING Poster - FNS 354 Be a Part of the ...

  7. EXPOSURE FACTORS HANDBOOK - FREQUENTLY ASKED QUESTIONS

    EPA Science Inventory

    This page provides a list of the most frequently asked questions and answers related to exposure factors. The following questions and answers have been compiled from inquiries made by users of the Exposure Factors Handbook. These questions and answers provide general information ...

  8. Frequent Collaborative Quiz Taking and Conceptual Learning

    ERIC Educational Resources Information Center

    Rezaei, Ali R.

    2015-01-01

    This quasi-experimental study reports on the effectiveness of three assessment strategies for students' performance. The primary goal was to determine whether there are any improvements in students' conceptual learning when a frequent (weekly) quiz is used for grading purposes compared to using midterm and final examinations only. Another goal was…

  9. Exploration Update

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Delores Beasley, NASA Public Affairs, introduces the panel who consist of: Scott "Doc" Horowitz, Associate Administrator of Exploration Systems from NASA Headquarters; Jeff Henley, Constellation Program Manager from NASA Johnson Space Flight Center; and Steve Cook, Manager Exploration Launch Office at NASA Marshall Space Flight Center. Scott Horowitz presents a short video entitled, "Ares Launching the Future". He further explains how NASA personnel came up with the name of Ares and where the name Ares was derived. Jeff Henley, updates the Constellation program and Steve Cook presents two slide presentations detailing the Ares l crew launch vehicle and Ares 5 cargo launch vehicle. A short question and answer period from the news media follows.

  10. [Pharmacovigilance update].

    PubMed

    Diezi, Léonore; Renard, Delphine; Rothuizen, Laura E; Livio, Françoise

    2014-01-15

    The main pharmacovigilance updates in 2013 are reviewed. Nitrofurantoin: lower efficacy and an increased risk of adverse events when creatinine clearance is below 60 ml/min. Dabigatran: contraindicated in patients with mechanical heart valves. Azithromycin: QT prolongation and increased risk of death. Zolpidem: towards a lower dosage. Roflumilast: avoid in patients known or at risk for mood disorders. Retigabine: indication restricted to last-line use and new monitoring requirements after reports of pigment changes in retina and other tissues. Telaprevir and rituximab: severe mucocutaneous reactions. Fingolimod: rare cases of progressive multifocal leucoencephalopathy. Tolvaptan: potential for hepatotoxicity. Nicotinic acid/laropiprant: suspension of marketing authorization as benefits no longer outweigh risks. PMID:24558915

  11. EPA DSSTox and ToxCast Project Updates: Generating New Data and Linkages in Support of Public Toxico-Cheminformatics Efforts

    EPA Science Inventory

    EPA’s National Center for Computational Toxicology is generating data and capabilities to support a new paradigm for toxicity screening and prediction. The DSSTox project is improving public access to quality structure-annotated chemical toxicity information in less summarized fo...

  12. Postdialysis Fatigue: A Frequent and Debilitating Symptom.

    PubMed

    Bossola, Maurizio; Tazza, Luigi

    2016-05-01

    Postdialysis fatigue (PDF) is a frequent and debilitating symptom of patients on chronic hemodialysis that affects their daily living and quality of life. Little is known about the mechanisms underlying this symptom and its severity. Only a few studies have investigated therapeutic interventions and with conflicting results. Given the major impact of PDF on the quality of life of hemodialysis patients, a larger effort is warranted to better understand, prevent, and treat PDF. PMID:26806879

  13. SNTEMP (In)frequently asked questions

    USGS Publications Warehouse

    Bartholow, J.M.

    2000-01-01

    Here, you will find a series of questions and answers resulting from many years of technical assistance with SNTEMP and SSTEMP. These (in)frequently asked questions are presented here so that you may get a feel for the range of questions posed, learn from the questions and their 'answers,' and share in the discussions if you wish. I certainly didn't answer all the questions, nor do I feel like I've got the only answer for them all.

  14. Recommendations on frequently encountered relief requests

    SciTech Connect

    Hartley, R.S.; Ransom, C.B.

    1992-01-01

    This paper is based on the review of a large database of requests for relief from enservice testing (1ST) requirements for pumps and valves. From the review, the paper identifies areas where enhancements to either the relief request process or the applicable test codes can improve IST of pumps and valves. Certain types of requests occur frequently. The paper examines some frequent requests and considers possible changes to the requirements to determine if the frequent requests can be eliminated. Recommended changes and their bases will be discussed. IST of safety-related pumps and valves at commercial nuclear power plants is done according to the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code (the Code), Section XI. Because of the design and function of some safety systems in nuclear plants, performing Code testing of certain pumps and valves is impractical or a hardship without a compensating increase in the level of safety. Deviations from the Code are allowed by law, as reviewed and approved by the United States Nuclear Regulatory Commission (NRC), through the relief request process. Because of similarities in plant design and system function, many problems encountered in testing components are similar from plant to plant. Likewise, there are often common problems associated with test methods or equipment. Therefore, many relief requests received by the NRC from various plants are similar. Identifying and addressing the root causes for these common requests will greatly improve IST.

  15. Recommendations on frequently encountered relief requests

    SciTech Connect

    Hartley, R.S.; Ransom, C.B.

    1992-09-01

    This paper is based on the review of a large database of requests for relief from enservice testing (1ST) requirements for pumps and valves. From the review, the paper identifies areas where enhancements to either the relief request process or the applicable test codes can improve IST of pumps and valves. Certain types of requests occur frequently. The paper examines some frequent requests and considers possible changes to the requirements to determine if the frequent requests can be eliminated. Recommended changes and their bases will be discussed. IST of safety-related pumps and valves at commercial nuclear power plants is done according to the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code (the Code), Section XI. Because of the design and function of some safety systems in nuclear plants, performing Code testing of certain pumps and valves is impractical or a hardship without a compensating increase in the level of safety. Deviations from the Code are allowed by law, as reviewed and approved by the United States Nuclear Regulatory Commission (NRC), through the relief request process. Because of similarities in plant design and system function, many problems encountered in testing components are similar from plant to plant. Likewise, there are often common problems associated with test methods or equipment. Therefore, many relief requests received by the NRC from various plants are similar. Identifying and addressing the root causes for these common requests will greatly improve IST.

  16. Guidelines for specialized nutritional and metabolic support in the critically-ill patient: update. Consensus SEMICYUC-SENPE: liver failure and liver transplantation.

    PubMed

    Montejo González, J C; Mesejo, A; Bonet Saris, A

    2011-11-01

    Patients with liver failure have a high prevalence of malnutrition, which is related to metabolic abnormalities due to the liver disease, reduced nutrient intake and alterations in digestive function, among other factors. In general, in patients with liver failure, metabolic and nutritional support should aim to provide adequate nutrient intake and, at the same time, to contribute to patients' recovery through control or reversal of metabolic alterations. In critically-ill patients with liver failure, current knowledge indicates that the organ failure is not the main factor to be considered when choosing the nutritional regimen. As in other critically-ill patients, the enteral route should be used whenever possible. The composition of the nutritional formula should be adapted to the patient's metabolic stress. Despite the physiopathological basis classically described by some authors who consider amino acid imbalance to be a triggering factor and key element in maintaining encephalopathy, there are insufficient data to recommend "specific" solutions (branched-chain amino acid-enriched with low aromatic amino acids) as part of nutritional support in patients with acute liver failure. In patients undergoing liver transplantation, nutrient intake should be started early in the postoperative period through transpyloric access. Prevention of the hepatic alterations associated with nutritional support should also be considered in distinct clinical scenarios. PMID:22411515

  17. Interim Control Strategy for the Test Area North/Technical Support Facility Sewage Treatment Facility Disposal Pond - Two-year Update

    SciTech Connect

    L. V. Street

    2007-04-01

    The Idaho Cleanup Project has prepared this interim control strategy for the U.S. Department of Energy Idaho Operations Office pursuant to DOE Order 5400.5, Chapter 11.3e (1) to support continued discharges to the Test Area North/Technical Support Facility Sewage Treatment Facility Disposal Pond. In compliance with DOE Order 5400.5, a 2-year review of the Interim Control Strategy document has been completed. This submittal documents the required review of the April 2005 Interim Control Strategy. The Idaho Cleanup Project's recommendation is unchanged from the original recommendation. The Interim Control Strategy evaluates three alternatives: (1) re-route the discharge outlet to an uncontaminated area of the TSF-07; (2) construct a new discharge pond; or (3) no action based on justification for continued use. Evaluation of Alternatives 1 and 2 are based on the estimated cost and implementation timeframe weighed against either alternative's minimal increase in protection of workers, the public, and the environment. Evaluation of Alternative 3, continued use of the TSF-07 Disposal Pond under current effluent controls, is based on an analysis of four points: - Record of Decision controls will protect workers and the public - Risk of increased contamination is low - Discharge water will be eliminated in the foreseeable future - Risk of contamination spread is acceptable. The Idaho Cleanup Project recommends Alternative 3, no action other than continued implementation of existing controls and continued deactivation, decontamination, and dismantlement efforts at the Test Area North/Technical Support Facility.

  18. An Update of the Ground Testing of the Li-ion Batteries in Support of JPL's 2003 Mars Exploration Rover Mission

    NASA Technical Reports Server (NTRS)

    Smart, Marshall C.; Ratnakumar, B. V.; Ewell, R. C.; Whitcanack, L. D.; Surampudi, S.; Puglia, F.; Gitzendanner, R.

    2006-01-01

    In early 2004, JPL successfully landed two Rovers, named Spirit and Opportunity, on the surface of Mars after traveling > 300 million miles over a 6-7 month period. In order to operate for extended duration (>9 months), both Rovers are equipped with rechargeable Lithium-ion batteries, which have enabled operation for over 854 and 834 Sols of operation, respectively, to date. Given that the batteries were required to support the mission for 90 Sols of operation by design, it is significant that the batteries have demonstrated over a nine fold increase in life over mission objectives. In addition to supporting the surface operations in conjunction with a triple-junction deployable solar arrays, the batteries were designed to aid in the launch and the EDL pyros, and allow for anomalies during cruise. In summary, the requirements of the Lithium-ion battery include the ability to provide power at least 90 sols on the surface of Mars, operate over a wide temperature range (-20 C to +30 C), withstand long storage periods (e.g., cruise period), operate in an inverted orientation, and support high current pulses (e.g., firing pyro events). In order to determine the viability of meeting these requirements, ground testing was performed on a Rover Battery Assembly Unit (RBAU), consisting of two 8-cell 10 Ah lithium-ion batteries connected in parallel. The RBAU upon which the performance testing was performed is nearly identical to the batteries incorporated into the two Rovers currently on Mars. The testing includes, (a) performing initial characterization tests (discharge capacity at different temperatures), (b) simulating the launch conditions, (c) simulating the cruise phase conditions (including trajectory correction maneuvers), (d) simulating the entry, decent, and landing (EDL) pulse load profile (required to support the pyros) (e) simulating the Mars surface operation mission simulation conditions, as well as, (f) assessing capacity loss and impedance characteristics as

  19. Activities update

    NASA Astrophysics Data System (ADS)

    Smith, Gerald A.

    1994-07-01

    The present report is an update on activities for the second year of funding. Research leading to a detailed characterization of antiproton annihilation in nuclei has resulted in a published analysis of fast deuteron production from carbon and uranium targets. This follows previously reported work and publications by our group on gamma-ray, neutral and charged pion, proton, and neutron production. The deuteron measurements are important to our SHIVA Star antiproton- catalyzed microfission experiment at the Phillips Laboratory, Kirtland AFB, in that they help constrain theoretical models of light nuclei production and subsequent energy deposition in the target. Work continues at SHIVA Star on working fluid formation and target compression for the microfission experiment. Excellent progress has been made, both theoretically and experimentally, on these important aspects of the experiment. The Penn State group, working in collaboration with Los Alamos National Laboratory physicists, trapped and held up to 721,000 antiprotons per beam injection pulse from the LEAR accelerator during July, 1993. This was a crucial step to the ultimate goal of transferring large numbers of antiprotons to the Phillips Laboratory for the antiproton-catalyzed microfission experiment.

  20. Working memory updating latency reflects the cost of switching between maintenance and updating modes of operation.

    PubMed

    Kessler, Yoav; Oberauer, Klaus

    2014-05-01

    Updating and maintenance of information are 2 conflicting demands on working memory (WM). We examined the time required to update WM (updating latency) as a function of the sequence of updated and not-updated items within a list. Participants held a list of items in WM and updated a variable subset of them in each trial. Four experiments that vary the number of to-be-updated and to-be-maintained items, as well as their positions in the list, are reported. The pattern of latencies was best explained by a model assuming forward scanning of the list, updating modified items, and maintaining nonmodified items. Switching between updating and maintenance incurred a response time cost, which increased with overall set-size. The formation of new item-position associations accounted for an additional response time component. The finding of an update-switch cost provides novel behavioral support for a class of physiologically inspired computational models, in which updating and maintenance require 2 different states of WM. PMID:24446752

  1. Spatially explicit modeling of annual and seasonal habitat for greater sage-grouse (Centrocercus urophasianus) in Nevada and Northeastern California—An updated decision-support tool for management

    USGS Publications Warehouse

    Coates, Peter S.; Casazza, Michael L.; Brussee, Brianne E.; Ricca, Mark A.; Gustafson, K. Benjamin; Sanchez-chopitea, Erika; Mauch, Kimberly; Niell, Lara; Gardner, Scott; Espinosa, Shawn; Delehanty, David J.

    2016-01-01

    Successful adaptive management hinges largely upon integrating new and improved sources of information as they become available. As a timely example of this tenet, we updated a management decision support tool that was previously developed for greater sage-grouse (Centrocercus urophasianus, hereinafter referred to as “sage-grouse”) populations in Nevada and California. Specifically, recently developed spatially explicit habitat maps derived from empirical data played a key role in the conservation of this species facing listing under the Endangered Species Act. This report provides an updated process for mapping relative habitat suitability and management categories for sage-grouse in Nevada and northeastern California (Coates and others, 2014, 2016). These updates include: (1) adding radio and GPS telemetry locations from sage-grouse monitored at multiple sites during 2014 to the original location dataset beginning in 1998; (2) integrating output from high resolution maps (1–2 m2) of sagebrush and pinyon-juniper cover as covariates in resource selection models; (3) modifying the spatial extent of the analyses to match newly available vegetation layers; (4) explicit modeling of relative habitat suitability during three seasons (spring, summer, winter) that corresponded to critical life history periods for sage-grouse (breeding, brood-rearing, over-wintering); (5) accounting for differences in habitat availability between more mesic sagebrush steppe communities in the northern part of the study area and drier Great Basin sagebrush in more southerly regions by categorizing continuous region-wide surfaces of habitat suitability index (HSI) with independent locations falling within two hydrological zones; (6) integrating the three seasonal maps into a composite map of annual relative habitat suitability; (7) deriving updated land management categories based on previously determined cut-points for intersections of habitat suitability and an updated index of sage

  2. Washington Update.

    ERIC Educational Resources Information Center

    Edelstein, Fritz; Larock, J. D.

    2003-01-01

    The main federal support for school modernization comes via the Qualified Zone Academy Board (QZAB) program, which helps districts raise funds and offers low-income schools freedom from bond and loan interest. The Better Classroom Act of 2003 proposes to extend the QZAB program by promoting new school construction. Two other bills currently before…

  3. HDF Update

    NASA Technical Reports Server (NTRS)

    Pourmal, Elena

    2016-01-01

    The HDF Group maintains and evolves HDF software used by NASA ESDIS program to manage remote sense data. In this talk we will discuss new features of HDF (Virtual Datasets, Single writerMultiple reader access, Community supported HDF5 compression filters) that address storage and IO performance requirements of the applications that work with the ESDIS data products.

  4. Updating Systematic Reviews: An International Survey

    PubMed Central

    Garritty, Chantelle; Tsertsvadze, Alexander; Tricco, Andrea C.; Sampson, Margaret; Moher, David

    2010-01-01

    Background Systematic reviews (SRs) should be up to date to maintain their importance in informing healthcare policy and practice. However, little guidance is available about when and how to update SRs. Moreover, the updating policies and practices of organizations that commission or produce SRs are unclear. Methodology/Principal Findings The objective was to describe the updating practices and policies of agencies that sponsor or conduct SRs. An Internet-based survey was administered to a purposive non-random sample of 195 healthcare organizations within the international SR community. Survey results were analyzed using descriptive statistics. The completed response rate was 58% (n = 114) from across 26 countries with 70% (75/107) of participants identified as producers of SRs. Among responders, 79% (84/107) characterized the importance of updating as high or very-high and 57% (60/106) of organizations reported to have a formal policy for updating. However, only 29% (35/106) of organizations made reference to a written policy document. Several groups (62/105; 59%) reported updating practices as irregular, and over half (53/103) of organizational respondents estimated that more than 50% of their respective SRs were likely out of date. Authors of the original SR (42/106; 40%) were most often deemed responsible for ensuring SRs were current. Barriers to updating included resource constraints, reviewer motivation, lack of academic credit, and limited publishing formats. Most respondents (70/100; 70%) indicated that they supported centralization of updating efforts across institutions or agencies. Furthermore, 84% (83/99) of respondents indicated they favoured the development of a central registry of SRs, analogous to efforts within the clinical trials community. Conclusions/Significance Most organizations that sponsor and/or carry out SRs consider updating important. Despite this recognition, updating practices are not regular, and many organizations lack a formal

  5. Legislative update

    NASA Astrophysics Data System (ADS)

    1984-04-01

    ARCTIC RESEARCH AND POLICY ACT, H.R. 2292 (Young, R-Alaska) and S. 373 (Murkowski, R-Alaska), would provide comprehensive national policy dealing with national needs and objectives in Arctic and would provide a centralized system for collection and retrieval of scientific data, establish priorities, and provide financial support for basic and applied scientific research. Senate Passed June 27, 1983 House Passed April 24, 1984

  6. Minimum Hamiltonian Ascent Trajectory Evaluation (MASTRE) program (update to automatic flight trajectory design, performance prediction, and vehicle sizing for support of Shuttle and Shuttle derived vehicles) engineering manual

    NASA Technical Reports Server (NTRS)

    Lyons, J. T.

    1993-01-01

    The Minimum Hamiltonian Ascent Trajectory Evaluation (MASTRE) program and its predecessors, the ROBOT and the RAGMOP programs, have had a long history of supporting MSFC in the simulation of space boosters for the purpose of performance evaluation. The ROBOT program was used in the simulation of the Saturn 1B and Saturn 5 vehicles in the 1960's and provided the first utilization of the minimum Hamiltonian (or min-H) methodology and the steepest ascent technique to solve the optimum trajectory problem. The advent of the Space Shuttle in the 1970's and its complex airplane design required a redesign of the trajectory simulation code since aerodynamic flight and controllability were required for proper simulation. The RAGMOP program was the first attempt to incorporate the complex equations of the Space Shuttle into an optimization tool by using an optimization method based on steepest ascent techniques (but without the min-H methodology). Development of the complex partial derivatives associated with the Space Shuttle configuration and using techniques from the RAGMOP program, the ROBOT program was redesigned to incorporate these additional complexities. This redesign created the MASTRE program, which was referred to as the Minimum Hamiltonian Ascent Shuttle TRajectory Evaluation program at that time. Unique to this program were first-stage (or booster) nonlinear aerodynamics, upper-stage linear aerodynamics, engine control via moment balance, liquid and solid thrust forces, variable liquid throttling to maintain constant acceleration limits, and a total upgrade of the equations used in the forward and backward integration segments of the program. This modification of the MASTRE code has been used to simulate the new space vehicles associated with the National Launch Systems (NLS). Although not as complicated as the Space Shuttle, the simulation and analysis of the NLS vehicles required additional modifications to the MASTRE program in the areas of providing

  7. Substance use treatment barriers for patients with frequent hospital admissions.

    PubMed

    Raven, Maria C; Carrier, Emily R; Lee, Joshua; Billings, John C; Marr, Mollie; Gourevitch, Marc N

    2010-01-01

    Substance use (SU) disorders adversely impact health status and contribute to inappropriate health services use. This qualitative study sought to determine SU-related factors contributing to repeated hospitalizations and to identify opportunities for preventive interventions. Fifty Medicaid-insured inpatients identified by a validated statistical algorithm as being at high-risk for frequent hospitalizations were interviewed at an urban public hospital. Patient drug/alcohol history, experiences with medical, psychiatric and addiction treatment, and social factors contributing to readmission were evaluated. Three themes related to SU and frequent hospitalizations emerged: (a) barriers during hospitalization to planning long-term treatment and follow-up, (b) use of the hospital as a temporary solution to housing/family problems, and (c) unsuccessful SU aftercare following discharge. These data indicate that homelessness, brief lengths of stay complicating discharge planning, patient ambivalence regarding long-term treatment, and inadequate detox-to-rehab transfer resources compromise substance-using patients' likelihood of avoiding repeat hospitalization. Intervention targets included supportive housing, detox-to-rehab transportation, and postdischarge patient support. PMID:19540700

  8. Horizontal subsea trees allow frequent deepwater workovers

    SciTech Connect

    Krenek, M.; Hall, G.; Sheng, W.Z.

    1995-05-01

    Horizontal subsea wellheads have found application in the Liuhua oil field in the South China Sea. These trees allow installation and retrieval of downhole equipment through the tree without having to disturb the tree or its external connections to flow lines, service lines, or control umbilicals. This access to the well is important because the Liuhua wells will be produced with electrical submersible pumps (ESPs), which may have relatively short intervals between maintenance, leading to frequent well work. The wells will be completed subsea in about 300 m of water. The large bore, horizontal trees allow all downhole equipment to be pulled without removal of the subsea tree. This wellhead configuration also provides well control and vertical access to downhole equipment through a conventional marine drilling riser and subsea blowout preventer (BOP), eliminating the need for costly specialized completion risers. Another benefit of the horizontal tree is its extremely compact profile with a low number of valves for well control. Valve size and spacing are decoupled from the size and bore spacing of the tubing hanger. The tree`s low profile geometry reduces costs of manufacturing the tree and framework and optimize load transfer to the wellhead.

  9. Forward scanning in verbal working memory updating.

    PubMed

    Kessler, Yoav; Oberauer, Klaus

    2015-12-01

    Effective use of working memory (WM) for high-level cognitive tasks requires coordinating two conflicting requirements: robust maintenance and rapid updating. Models of WM suggest that these demands are coordinated by a gate between perceptual input and WM. Previous work with a letter-updating paradigm (Kessler & Oberauer, Journal of Experimental Psychology: Learning, Memory, and Cognition, 40, 738-754, 2014) supported a scanning and gate-switching (SGS) model of WM updating. The present work provides further evidence for the SGS model. Participants were required to keep track of the last letter that appeared in each of a row of frames on the screen. On each updating step, a variable subset of letters in varying positions in the row had to be updated. The SGS model assumes that on each updating step, participants scan through the memory set sequentially, opening the gate when a letter requires updating, and closing the gate when the next letter needs to be maintained. As is predicted by the SGS model, the reaction times for each updating step increased with the number of updated items and with the number of gate switches. In addition, the present experiment provides direct evidence supporting the scanning assumption of the model. Hebrew-speaking participants performed the task with either Hebrew or English letter stimuli, in different blocks. As was predicted, the scanning direction of the stimulus set was from left to right in English and from right to left in Hebrew. The SGS model fit the data only when the scanning direction was taken into account, establishing the role of item-based forward scanning during WM updating. PMID:25962687

  10. Legislative update

    NASA Astrophysics Data System (ADS)

    Arctic Research And Policy Act, H.R. 2292 (Young, R-Alaska) and S. 373 (Murkowski, R-Alaska), would provide comprehensive national policy dealing with national needs and objectives in Arctic and would provide a centralized system for collection and retrieval of scientific data, establish priorities, and provide financial support for basic and applied scientific research. Senate version created a 5-person Arctic Science Council to establish policy and a 9-member commission to make research grants. Also authorized $25 million per year for 5 years. House Science and Technology Committee reported a new version that would establish a 6-member Arctic Research Commission responsible for developing policy and advising government agencies. Passed June 27, 1983 Reported Nov. 10, 1983

  11. Updating representations of temporal intervals.

    PubMed

    Danckert, James; Anderson, Britt

    2015-12-01

    Effectively engaging with the world depends on accurate representations of the regularities that make up that world-what we call mental models. The success of any mental model depends on the ability to adapt to changes-to 'update' the model. In prior work, we have shown that damage to the right hemisphere of the brain impairs the ability to update mental models across a range of tasks. Given the disparate nature of the tasks we have employed in this prior work (i.e. statistical learning, language acquisition, position priming, perceptual ambiguity, strategic game play), we propose that a cognitive module important for updating mental representations should be generic, in the sense that it is invoked across multiple cognitive and perceptual domains. To date, the majority of our tasks have been visual in nature. Given the ubiquity and import of temporal information in sensory experience, we examined the ability to build and update mental models of time. We had healthy individuals complete a temporal prediction task in which intervals were initially drawn from one temporal range before an unannounced switch to a different range of intervals. Separate groups had the second range of intervals switch to one that contained either longer or shorter intervals than the first range. Both groups showed significant positive correlations between perceptual and prediction accuracy. While each group updated mental models of temporal intervals, those exposed to shorter intervals did so more efficiently. Our results support the notion of generic capacity to update regularities in the environment-in this instance based on temporal information. The task developed here is well suited to investigations in neurological patients and in neuroimaging settings. PMID:26303026

  12. Updating Situation Models

    ERIC Educational Resources Information Center

    Zwaan, Rolf A.; Madden, Carol J.

    2004-01-01

    The authors examined how situation models are updated during text comprehension. If comprehenders keep track of the evolving situation, they should update their models such that the most current information, the here and now, is more available than outdated information. Contrary to this updating hypothesis, E. J. O'Brien, M. L. Rizzella, J. E.…

  13. Situation Model Updating in Young and Older Adults: Global versus Incremental Mechanisms

    PubMed Central

    Bailey, Heather R.; Zacks, Jeffrey M.

    2015-01-01

    Readers construct mental models of situations described by text. Activity in narrative text is dynamic, so readers must frequently update their situation models when dimensions of the situation change. Updating can be incremental, such that a change leads to updating just the dimension that changed, or global, such that the entire model is updated. Here, we asked whether older and young adults make differential use of incremental and global updating. Participants read narratives containing changes in characters and spatial location and responded to recognition probes throughout the texts. Responses were slower when probes followed a change, suggesting that situation models were updated at changes. When either dimension changed, responses to probes for both dimensions were slowed; this provides evidence for global updating. Moreover, older adults showed stronger evidence of global updating than did young adults. One possibility is that older adults perform more global updating to offset reduced ability to manipulate information in working memory. PMID:25938248

  14. Frequently asked questions: iodinated contrast agents.

    PubMed

    Bettmann, Michael A

    2004-10-01

    Although iodinated contrast agents are safe and widely used, adverse events occur and questions remain about their use, safety, and interactions. Some questions are easily answered and others still require extensive investigation. For one frequent question--is informed consent necessary before all contrast media injections--the simple answer is no. Another question concerns use of contrast media in patients with prior reactions or allergies. Contrast agents can be safely used in such patients, but special care must be taken to be aware of what the previous reaction was and to be ready to treat any reaction. The protective role of pre-treatment with steroids is well established for minor reactions, but they may not prevent major reactions. It is important to realize that even life-threatening, anaphylactoid reactions are not the result of a true allergy to contrast media. Many questions arise about contrast agent-induced nephropathy. Baseline serum creatinine values should be obtained in patients who are at risk, not all patients. The incidence and natural history of contrast agent-induced nephropathy remain unclear. It occurs only in patients with compromised renal function before contrast agent injection, but even patients with normal serum creatinine levels can have renal dysfunction. Calculated creatinine clearance is a better way to determine risk and to follow this complication. The outcome in almost all patients is benign, with progression to end-stage renal disease being rare. The major risk factors, in addition to renal dysfunction, are long-standing diabetes mellitus, dehydration, and use of other nephrotoxic medications. Recent work in preventing and ameliorating contrast agent-induced nephropathy with N-acetyl cysteine, substitution of an isosmolal nonionic contrast agent, and various hydration regimens has been promising. Another common concern is use of iodinated contrast agents in pregnant or breast-feeding women. In both cases, there is no evidence

  15. Lisfranc injuries: an update.

    PubMed

    Eleftheriou, Kyriacos I; Rosenfeld, Peter F; Calder, James D F

    2013-06-01

    Lisfranc injuries are a spectrum of injuries to the tarsometatarsal joint complex of the midfoot. These range from subtle ligamentous sprains, often seen in athletes, to fracture dislocations seen in high-energy injuries. Accurate and early diagnosis is important to optimise treatment and minimise long-term disability, but unfortunately, this is a frequently missed injury. Undisplaced injuries have excellent outcomes with non-operative treatment. Displaced injuries have worse outcomes and require anatomical reduction and internal fixation for the best outcome. Although evidence to date supports the use of screw fixation, plate fixation may avoid further articular joint damage and may have benefits. Recent evidence supports the use of limited arthrodesis in more complex injuries. PMID:23563815

  16. a Bottom-Up Geosptial Data Update Mechanism for Spatial Data Infrastructure Updating

    NASA Astrophysics Data System (ADS)

    Tian, W.; Zhu, X.; Liu, Y.

    2012-08-01

    Currently, the top-down spatial data update mechanism has made a big progress and it is wildly applied in many SDI (spatial data infrastructure). However, this mechanism still has some issues. For example, the update schedule is limited by the professional department's project, usually which is too long for the end-user; the data form collection to public cost too much time and energy for professional department; the details of geospatial information does not provide sufficient attribute, etc. Thus, how to deal with the problems has become the effective shortcut. Emerging Internet technology, 3S technique and geographic information knowledge which is popular in the public promote the booming development of geoscience in volunteered geospatial information. Volunteered geospatial information is the current "hotspot", which attracts many researchers to study its data quality and credibility, accuracy, sustainability, social benefit, application and so on. In addition to this, a few scholars also pay attention to the value of VGI to support the SDI updating. And on that basis, this paper presents a bottom-up update mechanism form VGI to SDI, which includes the processes of match homonymous elements between VGI and SDI vector data , change data detection, SDI spatial database update and new data product publication to end-users. Then, the proposed updating cycle is deeply discussed about the feasibility of which can detect the changed elements in time and shorten the update period, provide more accurate geometry and attribute data for spatial data infrastructure and support update propagation.

  17. The effect of frequent hemodialysis on nutrition and body composition: frequent Hemodialysis Network Trial.

    PubMed

    Kaysen, George A; Greene, Tom; Larive, Brett; Mehta, Ravindra L; Lindsay, Robert M; Depner, Tom A; Hall, Yoshio N; Daugirdas, John T; Chertow, Glenn M

    2012-07-01

    We investigated the effects of frequency of hemodialysis on nutritional status by analyzing the data in the Frequent Hemodialysis Network Trial. We compared changes in albumin, body weight, and composition among 245 patients randomized to six or three times per week in-center hemodialysis (Daily Trial) and 87 patients randomized to six times per week nocturnal or three times per week conventional hemodialysis, performed largely at home (Nocturnal Trial). In the Daily Trial, there were no significant differences between groups in changes in serum albumin or the equilibrated protein catabolic rate by 12 months. There was a significant relative decrease in predialysis body weight of 1.5 ± 0.2 kg in the six times per week group at 1 month, but this significantly rebounded by 1.3 ± 0.5 kg over the remaining 11 months. Extracellular water (ECW) decreased in the six times per week compared with the three per week hemodialysis group. There were no significant between-group differences in phase angle, intracellular water, or body cell mass (BCM). In the Nocturnal Trial, there were no significant between-group differences in any study parameter. Any gain in 'dry' body weight corresponded to increased adiposity rather than muscle mass but was not statistically significant. Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition. PMID:22456602

  18. ADAS Update and Maintainability

    NASA Technical Reports Server (NTRS)

    Watson, Leela R.

    2010-01-01

    Since 2000, both the National Weather Service Melbourne (NWS MLB) and the Spaceflight Meteorology Group (SMG) have used a local data integration system (LOIS) as part of their forecast and warning operations. The original LOIS was developed by the Applied Meteorology Unit (AMU) in 1998 (Manobianco and Case 1998) and has undergone subsequent improvements. Each has benefited from three-dimensional (3-D) analyses that are delivered to forecasters every 15 minutes across the peninsula of Florida. The intent is to generate products that enhance short-range weather forecasts issued in support of NWS MLB and SMG operational requirements within East Central Florida. The current LDIS uses the Advanced Regional Prediction System (ARPS) Data Analysis System (AD AS) package as its core, which integrates a wide variety of national, regional, and local observational data sets. It assimilates all available real-time data within its domain and is run at a finer spatial and temporal resolution than current national or regional-scale analysis packages. As such, it provides local forecasters with a more comprehensive understanding of evolving fine-scale weather features. Over the years, the LDIS has become problematic to maintain since it depends on AMU-developed shell scripts that were written for an earlier version of the ADAS software. The goals of this task were to update the NWS MLB/SMG LDIS with the latest version of ADAS, incorporate new sources of observational data, and upgrade and modify the AMU-developed shell scripts written to govern the system. In addition, the previously developed ADAS graphical user interface (GUI) was updated. Operationally, these upgrades will result in more accurate depictions of the current local environment to help with short-range weather forecasting applications, while also offering an improved initialization for local versions of the Weather Research and Forecasting (WRF) model used by both groups.

  19. Treatment of Warts in Children: An Update.

    PubMed

    Gerlero, P; Hernández-Martín, Á

    2016-09-01

    Warts are among the most common skin infections in children. Although numerous treatment options are available, none are completely effective in a single session. Treatment is particularly complicated in children, not only because certain treatments are poorly tolerated, but also because parents frequently have unrealistic expectations. In this article, we offer an update on the treatments available for warts, focusing specifically on pediatric patients. We do not discuss treatments for oral and anogenital warts. PMID:27241712

  20. Moving Objects Updating

    NASA Astrophysics Data System (ADS)

    Chen, Jidong; Meng, Xiaofeng

    In moving objects applications, large numbers of locations can be sampled by sensors or GPS periodically, then sent from moving clients to the server and stored in a database. Therefore, continuously maintaining in a database the current locations of moving objects by using a tracking technique becomes very important. The key issue is minimizing the number of updates, while providing precise locations for query results. In this chapter, we will introduce some underlying location update methods. Then, we describe two location update strategies in detail, which can improve the performance. One is the proactive location update strategy, which predicts the movement of moving objects to lower the update frequency; the other is the group location update strategy, which groups the objects to minimize the total number of objects reporting their locations.

  1. CLINICAL PRACTICE GUIDELINES FOR THE PERIOPERATIVE NUTRITIONAL, METABOLIC, AND NONSURGICAL SUPPORT OF THE BARIATRIC SURGERY PATIENT—2013 UPDATE: COSPONSORED BY AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, THE OBESITY SOCIETY, AND AMERICAN SOCIETY FOR METABOLIC & BARIATRIC SURGERY★

    PubMed Central

    Mechanick, Jeffrey I.; Youdim, Adrienne; Jones, Daniel B.; Garvey, W. Timothy; Hurley, Daniel L.; McMahon, M. Molly; Heinberg, Leslie J.; Kushner, Robert; Adams, Ted D.; Shikora, Scott; Dixon, John B.; Brethauer, Stacy

    2014-01-01

    The development of these updated guidelines was commissioned by the AACE, TOS, and ASMBS Board of Directors and adheres to the AACE 2010 protocol for standardized production of clinical practice guidelines (CPG). Each recommendation was re-evaluated and updated based on the evidence and subjective factors per protocol. Examples of expanded topics in this update include: the roles of sleeve gastrectomy, bariatric surgery in patients with type-2 diabetes, bariatric surgery for patients with mild obesity, copper deficiency, informed consent, and behavioral issues. There are 74 recommendations (of which 56 are revised and 2 are new) in this 2013 update, compared with 164 original recommendations in 2008. There are 403 citations, of which 33 (8.2%) are EL 1, 131 (32.5%) are EL 2, 170 (42.2%) are EL 3, and 69 (17.1%) are EL 4. There is a relatively high proportion (40.4%) of strong (EL 1 and 2) studies, compared with only 16.5% in the 2008 AACE- TOS-ASMBS CPG. These updated guidelines reflect recent additions to the evidence base. Bariatric surgery remains a safe and effective intervention for select patients with obesity. A team approach to perioperative care is mandatory with special attention to nutritional and metabolic issues. PMID:23529351

  2. Clinical Practice Guidelines for the Perioperative Nutritional, Metabolic, and Nonsurgical Support of the Bariatric Surgery Patient—2013 Update: Cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery*

    PubMed Central

    Mechanick, Jeffrey I.; Youdim, Adrienne; Jones, Daniel B.; Garvey, W. Timothy; Hurley, Daniel L.; McMahon, Molly; Heinberg, Leslie J.; Kushner, Robert; Adams, Ted D.; Shikora, Scott; Dixon, John B.; Brethauer, Stacy

    2014-01-01

    The development of these updated guidelines was commissioned by the AACE, TOS, and ASMBS Board of Directors and adheres to the AACE 2010 protocol for standardized production of clinical practice guidelines (CPG). Each recommendation was re-evaluated and updated based on the evidence and subjective factors per protocol. Examples of expanded topics in this update include: the roles of sleeve gastrectomy, bariatric surgery in patients with type-2 diabetes, bariatric surgery for patients with mild obesity, copper deficiency, informed consent, and behavioral issues. There are 74 recommendations (of which 56 are revised and 2 are new) in this 2013 update, compared with 164 original recommendations in 2008. There are 403 citations, of which 33 (8.2%) are EL 1, 131 (32.5%) are EL 2, 170 (42.2%) are EL 3, and 69 (17.1%) are EL 4. There is a relatively high proportion (40.4%) of strong (EL 1 and 2) studies, compared with only 16.5% in the 2008 AACE-TOS-ASMBS CPG. These updated guidelines reflect recent additions to the evidence base. Bariatric surgery remains a safe and effective intervention for select patients with obesity. A team approach to perioperative care is mandatory with special attention to nutritional and metabolic issues. PMID:23529939

  3. ISS Update: Suitport

    NASA Video Gallery

    ISS Update commentator Lynnette Madison interviews Mallory Jennings, Suitport Human Testing Lead, about making spacewalks easier and more efficient with the Suitport. Questions? Ask us on Twitter @...

  4. Updating in Models of Spatial Memory

    NASA Astrophysics Data System (ADS)

    Rump, Björn; McNamara, Timothy P.

    This chapter discusses a new model of spatial memory and updating. The model includes an egocentric subsystem that computes and represents transient self-to-object spatial relations and an environmental subsystem that forms enduring representations of environments using intrinsic reference systems. Updating occurs in both subsystems, but only the egocentric subsystem readily provides object locations relative to any adopted orientation. In the absence of visual support, updating in the egocentric subsystem is limited, and object locations may have to be retrieved from the orientation dependent environmental subsystem. The model is evaluated in light of the results of numerous studies from the areas of spatial memory and spatial updating and contrasted with two alternative models. Furthermore, results are presented that suggest that interobject spatial relations are preferentially represented when they are aligned with intrinsic reference directions in the environmental subsystem.

  5. 77 FR 64562 - Draft Emergency Preparedness Frequently Asked Questions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Emergency Preparedness Frequently Asked Questions AGENCY: Nuclear Regulatory Commission... Commission (NRC) is making available for comment Emergency Preparedness (EP) frequently asked...

  6. 78 FR 52570 - Draft Emergency Preparedness Frequently Asked Questions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Emergency Preparedness Frequently Asked Questions AGENCY: Nuclear Regulatory Commission... Commission (NRC) is making available for comment Emergency Preparedness (EP) frequently asked...

  7. 78 FR 33862 - Draft Emergency Preparedness Frequently Asked Questions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Emergency Preparedness Frequently Asked Questions AGENCY: Nuclear Regulatory Commission... Commission (NRC) is making available for comment Emergency Preparedness (EP) frequently asked...

  8. Adherence to health regimens among frequent attenders of Finnish healthcare

    PubMed Central

    Hirsikangas, Sari; Kanste, Outi; Korpelainen, Juha; Kyngäs, Helvi

    2016-01-01

    Objectives The aim of the study was to describe adherence to health regimens and the factors associated with it among adult frequent attenders (FAs). Design This was a cross-sectional study. The study sample consisted of 462 healthcare FAs in 7 municipal health centres in northern Finland. An FA is a person who has had 8 or more outpatient visits to a GP (in a health centre) or 4 or more outpatient visits to a university hospital during 1 year. The main outcome was self-reported adherence to health regimens. Results Of the FAs, 82% adhered well to their health regimens. Carrying out self-care, medical care and feeling responsible for self-care were the most significant predictors to good adherence in all models. No significant differences in adherence were found in male and female subjects, age groups or educational levels. Support from healthcare providers and support from relatives were not significant predictors of good adherence. Conclusion FAs in Finland adhere well to health regimens and exceptionally well to medication. Variables that predict the best adherence of FAs to health regimens are carrying out self-care, receiving medical care and feeling responsible for self-care. PMID:26996780

  9. Acute Decompensated Heart Failure Update

    PubMed Central

    Teerlink, John R; Alburikan, Khalid; Metra, Marco; Rodgers, Jo E

    2015-01-01

    Acute decompensated heart failure (ADHF) continues to increase in prevalence and is associated with substantial mortality and morbidity including frequent hospitalizations. The American Heart Association is predicting that more than eight million Americans will have heart failure by 2030 and that the total direct costs associated with the disease will rise from $21 billion in 2012 to $70 billion in 2030. The increase in the prevalence and cost of HF is primarily the result of shifting demographics and a growing population. Although many large, randomized, controlled clinical trials have been conducted in patients with chronic heart failure, it was not until recently that a growing number of studies began to address the management of ADHF. It is the intent of this review to update the clinician regarding the evaluation and optimal management of ADHF. PMID:24251454

  10. Research Results and Information Update

    NASA Astrophysics Data System (ADS)

    2011-01-01

    Research Results Monsoon behavior balanced by glaciers Research Discovers Frequent Mutations of Chromatin Significant Progress in Water Photochemistry Research Structural signature in amorphous alloy formation and plastic deformation The neural basis of Drosophila larval light/darkness preference Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity Determination of electron pairing symmetry of iron-based superconductor FeSe Long-Range Topological Order in Metallic Glass Information Update List of Projects Jointly Funded by NSFC and CNRS in 2011 List of Projects Jointly Funded by NSFC and ESRC in 2011 List of Projects Jointly Funded by NSFC and RS in 2011 List of Projects Jointly Funded by NSFC and RSE in 2011 Funding of Major Program Projects in 2010 Funding of Key Program Projects in 2010

  11. The template update problem.

    PubMed

    Matthews, Iain; Ishikawa, Takahiro; Baker, Simon

    2004-06-01

    Template tracking dates back to the 1981 Lucas-Kanade algorithm. One question that has received very little attention, however, is how to update the template so that it remains a good model of the tracked object. We propose a template update algorithm that avoids the "drifting" inherent in the naive algorithm. PMID:18579941

  12. Country Update: Israel 2005

    ERIC Educational Resources Information Center

    Marar, Marianne Maurice

    2005-01-01

    Country Updates is a new section of "Intercultural Education." Starting in "Intercultural Education," Volume 16 No. 5, this column will focus on recent developments during the last two to three years in the field of intercultural education in one particular country. These updates can include recent policy decisions, the main results of important…

  13. Zika Virus Infection and Zika Fever: Frequently Asked Questions

    MedlinePlus

    ... Updated: 25 March 2016 ABOUT ZIKA What is Zika virus infection? Zika virus infection is caused by the ... possible to characterize the disease better. How is Zika virus transmitted? Zika virus is transmitted to people through ...

  14. Genomics and Health Impact Update

    MedlinePlus

    ... Genomics in Practice Newborn Screening Pharmacogenomics Reproductive Health Tools and Databases About the Genomics & Health Impact Update The Office of Public Health Genomics provides updated and credible ...

  15. Hypersensitivity and vaccines: an update.

    PubMed

    Barbaud, Annick; Deschildre, Antoine; Waton, Julie; Raison-Peyron, Nadia; Tréchot, Philippe

    2013-04-01

    Allergic reactions to vaccines can be classified as sensitivity to one of the vaccine components, pseudo-allergic reactions, often after hyperimmunization, and exacerbation of atopic symptoms or vasculitis. Pseudo-allergic reactions, some possibly due to hyperimmunization, are probably more common than true allergies. Atopic reactions should not be confused with the "flash" phenomenon, defined as an exacerbation of an allergic reaction due to a reduction in the allergic reactivity threshold following the vaccine injection. BCGitis occurs frequently, and for this reason, guidelines for Bacillus Calmette-Guérin (BCG) have been modified. The vaccine is now reserved for people at risk of exposure to Mycobacterium tuberculosis. This review provides an update on the vaccination modalities for people allergic to eggs, on the assessment that should be performed when a reaction occurs due to tetanus vaccination, on the urticaria after hepatitis vaccination, on an aluminum granuloma, which is more and more frequent in young children, and vasculitis after flu vaccination and BCGitis. The side effects associated with new, recently released vaccines, such as anti-influenza A H1N1 or anti-human papilloma virus (HPV) will also be presented. PMID:23238161

  16. Learning from failure in health care: frequent opportunities, pervasive barriers.

    PubMed

    Edmondson, A C

    2004-12-01

    The notion that hospitals and medical practices should learn from failures, both their own and others', has obvious appeal. Yet, healthcare organisations that systematically and effectively learn from the failures that occur in the care delivery process, especially from small mistakes and problems rather than from consequential adverse events, are rare. This article explores pervasive barriers embedded in healthcare's organisational systems that make shared or organisational learning from failure difficult and then recommends strategies for overcoming these barriers to learning from failure, emphasising the critical role of leadership. Firstly, leaders must create a compelling vision that motivates and communicates urgency for change; secondly, leaders must work to create an environment of psychological safety that fosters open reporting, active questioning, and frequent sharing of insights and concerns; and thirdly, case study research on one hospital's organisational learning initiative suggests that leaders can empower and support team learning throughout their organisations as a way of identifying, analysing, and removing hazards that threaten patient safety. PMID:15576689

  17. Updated Trends in Materials' Outgassing Technology

    NASA Technical Reports Server (NTRS)

    Rosecrans, Glenn; Mlucciacciaro, Anthony

    2010-01-01

    This slide presentation reviews the trends in materials' outgassing. The work utilized a database of reports to identify common outgassing chemical species from flight hardware, spacecraft, and ground support equipment (GSE). This work updates an earlier work that reported on chemical analysis from 1970-1978.

  18. Frequent visitors to psychiatric emergency services: staff attitudes and temporal patterns.

    PubMed

    Arfken, Cynthia; Zeman, Lori Lackman; Yeager, Lindsay; Mischel, Edward; Amirsadri, Alireza

    2002-11-01

    Providing quality psychiatric emergency services is becoming more difficult as utilization rates soar, especially by individuals who are frequent visitors. To address this issue, a staff survey and analysis of admission patterns were conducted. Staff were more likely to believe that frequent visitors sought care because they had difficulty accessing alternative services, had basic needs unmet, were substance abusers, wanted inpatient admission, and were noncompliant with treatment plans. The 1999 temporal admission pattern documented that frequent visitors' admissions were higher during the first week of the month and inclement weather. Surprisingly, the infrequent visitors' admissions also were higher during the first week of the month. Together, these findings suggest that, in this urban location, frequent visitors are disadvantaged individuals lacking support and alternative treatment settings who use psychiatric emergency services to meet basic needs. PMID:12404943

  19. Pain in IBD Patients: Very Frequent and Frequently Insufficiently Taken into Account

    PubMed Central

    Ak, Melike; Müller-Mottet, Séverine; Scharl, Sylvie; Biedermann, Luc; Fournier, Nicolas; Frei, Pascal; Pittet, Valerie; Scharl, Michael; Fried, Michael

    2016-01-01

    Background Pain is a common symptom related to inflammatory bowel disease (IBD). In addition to abdominal pain, pain can also be an extraintestinal manifestation of IBD. Pain treatment is challenging and a substantial part of IBD patients are treated with opioids. Therefore, a better knowledge on pain symptoms is crucial for a better therapeutic approach to this clinical problem. Methods Patients of the Swiss IBD Cohort Study (SIBDCS) (n = 2152) received a questionnaire regarding pain intensity, pain localization and impact of pain on daily life and social activities. Furthermore, the questionnaire investigated the use of pain-specific medication. Results A vast majority of patients (71%) experienced pain during the disease course. For a substantial part of patients (49% in UC and 55% in CD) pain is a longstanding problem (>5 years). Pain in UC was of shorter duration compared to CD (p < 0.01). Abdominal pain (59.5%) and back pain (38.3%) were the main pain localizations. 67% of patients took pain medication; 24% received no pain treatment. The general quality of life was significantly lower in patients suffering of pain compared to those without pain (38 vs. 77; (-100 very bad; 100 very good) p<0.0001). Conclusions Prevalence of pain is high in patients of the SIBDCS. It is a longstanding problem for the majority of the patients affected. Pain was found to be undertreated in the SIBDCS and was significantly associated with health-related quality of life. Thus, an increased awareness is mandatory to address this frequent complication in the course of IBD. PMID:27332879

  20. ISS Update: Suitport Testing

    NASA Video Gallery

    ISS Update commentator Lynnette Madison interviews Joel Maganza, Test Director, about thermal vacuum chambers and unmanned and human-testing with the Suitport. Questions? Ask us on Twitter @NASA_Jo...

  1. ISS Update: NEEMO 16

    NASA Video Gallery

    ISS Update commentator Josh Byerly interviews astronaut Stan Love about the NEEMO 16 mission from Aquarius Base. Questions? Ask us on Twitter @NASA_Johnson and include the hashtag #askStation. For ...

  2. The Analysis of Verbal Behavior: a Status Update.

    PubMed

    Luke, Molli M; Carr, James E

    2015-10-01

    We analyzed past volumes of The Analysis of Verbal Behavior (TAVB) to provide a comprehensive status update after 30 years of publication. Data on TAVB's content, frequent contributors, and scholarly impact suggest a healthy state of the journal. PMID:27606209

  3. 75 FR 59322 - Notice of Availability of Answers to Frequently Asked Questions Regarding Buy America & FRA's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... Buy America & FRA's High-Speed Intercity Passenger Rail Program AGENCY: Federal Railroad...'s High Speed Intercity ] Passenger Rail Program. The Answers to Frequently Asked Questions can be... to support intercity passenger rail service (Sec. 301), high-speed corridor development (Sec....

  4. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009.

    PubMed

    Yatham, Lakshmi N; Kennedy, Sidney H; Schaffer, Ayal; Parikh, Sagar V; Beaulieu, Serge; O'Donovan, Claire; MacQueen, Glenda; McIntyre, Roger S; Sharma, Verinder; Ravindran, Arun; Young, L Trevor; Young, Allan H; Alda, Martin; Milev, Roumen; Vieta, Eduard; Calabrese, Joseph R; Berk, Michael; Ha, Kyooseob; Kapczinski, Flávio

    2009-05-01

    The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with the International Society for Bipolar Disorders (ISBD), reviews new evidence and is designed to be used in conjunction with the previous publications. The recommendations for the management of acute mania remain mostly unchanged. Lithium, valproate, and several atypical antipsychotics continue to be first-line treatments for acute mania. Tamoxifen is now suggested as a third-line augmentation option. The combination of olanzapine and carbamazepine is not recommended. For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first-line options. New data support the use of adjunctive modafinil as a second-line option, but also indicate that aripiprazole should not be used as monotherapy for bipolar depression. Lithium, lamotrigine, valproate, and olanzapine continue to be first-line options for maintenance treatment of bipolar disorder. New data support the use of quetiapine monotherapy and adjunctive therapy for the prevention of manic and depressive events, aripiprazole monotherapy for the prevention of manic events, and risperidone long-acting injection monotherapy and adjunctive therapy, and adjunctive ziprasidone for the prevention of mood events. Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients' lives. This update provides an expanded look at bipolar II disorder. PMID:19419382

  5. Frequently Asked Questions: IDEA Early Childhood--Disclosure Avoidance

    ERIC Educational Resources Information Center

    Center for IDEA Early Childhood Data Systems (DaSy), 2014

    2014-01-01

    This 2014 document is an adaptation of the 2012 release of "Frequently Asked Questions--Disclosure Avoidance" intended for K-12 audiences. Presented here in the form of responses to frequently asked questions (FAQs) are suggestions intended to provide guidance to IDEA Part C early intervention and Part B 619 preschool special education…

  6. [Congestive heart failure with frequent hospital readmissions in the elderly].

    PubMed

    Pentimone, F; Del Corso, L

    1993-03-01

    Ten elderly patients with heart failure and frequent hospital readmission within 12 months before the study, were submitted to clinical radiologic, electrocardiographic and echocardiographic evaluation in order to find the causes of readmission. The most frequent factors were found to be non compliance with drug prescriptions and therapy inadequate for the etiology of the heart failure and the kind of cardiac dysfunction. PMID:8482059

  7. 77 FR 25504 - Draft Emergency Preparedness Frequently Asked Questions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... COMMISSION Draft Emergency Preparedness Frequently Asked Questions AGENCY: Nuclear Regulatory Commission... asked questions (EPFAQs). These EPFAQs will be used to provide clarification of guidance documents... Frequently Asked Questions is available electronically under ADAMS Accession Number ML12108A151, and it...

  8. Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions.

    PubMed

    Ang, Daphne C; Warrick, Andrea L; Shilling, Amy; Beadling, Carol; Corless, Christopher L; Troxell, Megan L

    2014-05-01

    The phosphatidylinositol-3-kinase pathway is one of the most commonly altered molecular pathways in invasive breast carcinoma, with phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) mutations in 25% of invasive carcinomas. Ductal carcinoma in situ (DCIS), benign papillomas, and small numbers of columnar cell lesions harbor an analogous spectrum of PIK3CA and AKT1 mutations, yet there is little data on usual ductal hyperplasia and atypical ductal and lobular neoplasias. We screened 192 formalin-fixed paraffin-embedded breast lesions from 75 patients for point mutations using a multiplexed panel encompassing 643 point mutations across 53 genes, including 58 PIK3CA substitutions. PIK3CA point mutations were identified in 31/62 (50%) proliferative lesions (usual ductal hyperplasia and columnar cell change), 10/14 (71%) atypical hyperplasias (atypical ductal hyperplasia and flat epithelial atypia), 7/16 (44%) lobular neoplasias (atypical lobular hyperplasia and lobular carcinoma in situ), 10/21 (48%) DCIS, and 13/37 (35%) invasive carcinomas. In genotyping multiple lesions of different stage from the same patient/specimen, we found considerable heterogeneity; most notably, in 12 specimens the proliferative lesion was PIK3CA mutant but the concurrent carcinoma was wild type. In 11 additional specimens, proliferative epithelium and cancer contained different point mutations. The frequently discordant genotypes of usual ductal hyperplasia/columnar cell change and concurrent carcinoma support a role for PIK3CA-activating point mutations in breast epithelial proliferation, perhaps more so than transformation. Further, these data suggest that proliferative breast lesions are heterogeneous and may represent non-obligate precursors of invasive carcinoma. PMID:24186142

  9. Diabetes update: population management.

    PubMed

    Erlich, Deborah R; Slawson, David C; Shaughnessy, Allen

    2013-05-01

    To optimally care for diabetes patients, physicians must adopt a systematic approach to managing the entire panel. At the heart of excellent care is a multidisciplinary health care team working in a patient-centered environment. Options to supplement traditional office visits include shared medical appointments (ie, group visits), patient self-management education, and social media for patient support and education. Educating patients about diabetes is associated with more frequent recommended screening, improved objective measures, cost savings, and improved short-term quality of life, especially when behavioral goal setting is incorporated. Participation in a nurse-led diabetes management program or an outreach program is associated with reduced health care costs and increased receipt of recommended screening and testing for patients with diabetes; implementation of an electronic database or registry system also is associated with these benefits. Some studies show that these interventions are associated with improvements in A1c; however, outcomes data are limited. Formats for group visits vary. Evidence suggests that patients with diabetes who participate in a group education program have lower A1c levels, improved lipid profiles, higher quality of life scores, and improved knowledge about diabetes and problem-solving ability. PMID:23690376

  10. Long-Term Effects of Frequent In-Center Hemodialysis.

    PubMed

    Chertow, Glenn M; Levin, Nathan W; Beck, Gerald J; Daugirdas, John T; Eggers, Paul W; Kliger, Alan S; Larive, Brett; Rocco, Michael V; Greene, Tom

    2016-06-01

    The Frequent Hemodialysis Network Daily Trial randomized 245 patients to receive six (frequent) or three (conventional) in-center hemodialysis sessions per week for 12 months. As reported previously, frequent in-center hemodialysis yielded favorable effects on the coprimary composite outcomes of death or change in left ventricular mass and death or change in self-reported physical health. Here, we determined the long-term effects of the 12-month frequent in-center hemodialysis intervention. We determined the vital status of patients over a median of 3.6 years (10%-90% range, 1.5-5.3 years) after randomization. Using an intention to treat analysis, we compared the mortality hazard in randomized groups. In a subset of patients from both groups, we reassessed left ventricular mass and self-reported physical health a year or more after completion of the intervention; 20 of 125 patients (16%) randomized to frequent hemodialysis died during the combined trial and post-trial observation periods in contrast to 34 of 120 patients (28%) randomized to conventional hemodialysis. The relative mortality hazard for frequent versus conventional hemodialysis was 0.54 (95% confidence interval, 0.31 to 0.93); with censoring of time after kidney transplantation, the relative hazard was 0.56 (95% confidence interval, 0.32 to 0.99). Bayesian analysis suggested a relatively high probability of clinically significant benefit and a very low probability of harm with frequent hemodialysis. In conclusion, a 12-month frequent in-center hemodialysis intervention significantly reduced long-term mortality, suggesting that frequent hemodialysis may benefit selected patients with ESRD. PMID:26467779

  11. Online updating of synthetic vision system databases

    NASA Astrophysics Data System (ADS)

    Simard, Philippe

    In aviation, synthetic vision systems render artificial views of the world (using a database of the world and pose information) to support navigation and situational awareness in low visibility conditions. The database needs to be periodically updated to ensure its consistency with reality, since it reflects at best a nominal state of the environment. This thesis presents an approach for automatically updating the geometry of synthetic vision system databases and 3D models in general. The approach is novel in that it profits from all of the available prior information: intrinsic/extrinsic camera parameters and geometry of the world. Geometric inconsistencies (or anomalies) between the model and reality are quickly localized; this localization serves to significantly reduce the complexity of the updating problem. Given a geometric model of the world, a sample image and known camera motion, a predicted image can be generated based on a differential approach. Model locations where predictions do not match observations are assumed to be incorrect. The updating is then cast as an optimization problem where differences between observations and predictions are minimized. To cope with system uncertainties, a mechanism that automatically infers their impact on prediction validity is derived. This method not only renders the anomaly detection process robust but also prevents the overfitting of the data. The updating framework is examined at first using synthetic data and further tested in both a laboratory environment and using a helicopter in flight. Experimental results show that the algorithm is effective and robust across different operating conditions.

  12. Sweet Syndrome: A Review and Update.

    PubMed

    Villarreal-Villarreal, C D; Ocampo-Candiani, J; Villarreal-Martínez, A

    2016-06-01

    Sweet syndrome is the most representative entity of febrile neutrophilic dermatoses. It typically presents in patients with pirexya, neutrophilia, painful tender erytomatous papules, nodules and plaques often distributed asymmetrically. Frequent sites include the face, neck and upper extremities. Affected sites show a characteristical neutrophilic infiltrate in the upper dermis. Its etiology remains elucidated, but it seems that can be mediated by a hypersensitivity reaction in which cytokines, followed by infiltration of neutrophils, may be involved. Systemic corticosteroids are the first-line of treatment in most cases. We present a concise review of the pathogenesis, classification, diagnosis and treatment update of this entity. PMID:26826881

  13. Answers to frequently asked questions about cleanup activities at Three Mile Island, Unit 2

    SciTech Connect

    Not Available

    1984-03-01

    This question-and-answer report provides answers in nontechnical language to frequently asked questions about the status of cleanup activities at Three Mile Island, Unit 2. The answers update information first prepared in 1981, shortly after the cleanup got under way. Since then, a variety of important developments in the cleanup has occurred. The information in the report should be read in conjunction with NUREG 1060, a discussion of increased occupational exposure estimates for the cleanup. The questions and answers in this report cover purpose and community involvement, decontamination of water and reactor, fuel removal, radwaste transport, environmental impact, social and economic effects, worker exposures and safety, radiation monitoring, potential for accidents, and schedule and funding.

  14. 223. FREQUENTLY REPRODUCED VIEW OF GWMP SHOWING VARIABLE WIDTH MEDIANS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    223. FREQUENTLY REPRODUCED VIEW OF GWMP SHOWING VARIABLE WIDTH MEDIANS WITH INDEPENDENT ALIGNMENTS FROM KEY BRIDGE LOOKING NORTHWEST, 1953. - George Washington Memorial Parkway, Along Potomac River from McLean to Mount Vernon, VA, Mount Vernon, Fairfax County, VA

  15. Vytra Healthcare forms a frequent user plan focusing on wellness.

    PubMed

    Herreria, J

    1998-01-01

    Vytra Healthcare's "Constellation Club" marks the first time the concept of wellness has been applied to health plans. The Constellation Club is comparable to a frequent flier club in the airline industry. PMID:10186393

  16. Frequently Asked Questions about Cell Phones and Your Health

    MedlinePlus

    ... Procedures Radiation in Everyday Objects Air Travel Airport Security Screening Building Materials Cigarette Smoking and Radiation Frequently Asked Questions about Cell Phones and Your Health Ultraviolet Radiation Wearable Computers and Wearable Technology Radiation in Nature Radon in ...

  17. Unsupervised mining of frequent tags for clinical eligibility text indexing.

    PubMed

    Miotto, Riccardo; Weng, Chunhua

    2013-12-01

    Clinical text, such as clinical trial eligibility criteria, is largely underused in state-of-the-art medical search engines due to difficulties of accurate parsing. This paper proposes a novel methodology to derive a semantic index for clinical eligibility documents based on a controlled vocabulary of frequent tags, which are automatically mined from the text. We applied this method to eligibility criteria on ClinicalTrials.gov and report that frequent tags (1) define an effective and efficient index of clinical trials and (2) are unlikely to grow radically when the repository increases. We proposed to apply the semantic index to filter clinical trial search results and we concluded that frequent tags reduce the result space more efficiently than an uncontrolled set of UMLS concepts. Overall, unsupervised mining of frequent tags from clinical text leads to an effective semantic index for the clinical eligibility documents and promotes their computational reuse. PMID:24036004

  18. Unsupervised Mining of Frequent Tags for Clinical Eligibility Text Indexing

    PubMed Central

    Miotto, Riccardo; Weng, Chunhua

    2013-01-01

    Clinical text, such as clinical trial eligibility criteria, is largely underused in state-of-the-art medical search engines due to difficulties of accurate parsing. This paper proposes a novel methodology to derive a semantic index for clinical eligibility documents based on a controlled vocabulary of frequent tags, which are automatically mined from the text. We applied this method to eligibility criteria on ClinicalTrials.gov and report that frequent tags (1) define an effective and efficient index of clinical trials and (2) are unlikely to grow radically when the repository increases. We proposed to apply the semantic index to filter clinical trial search results and we concluded that frequent tags reduce the result space more efficiently than an uncontrolled set of UMLS concepts. Overall, unsupervised mining of frequent tags from clinical text leads to an effective semantic index for the clinical eligibility documents and promotes their computational reuse. PMID:24036004

  19. 78 FR 72122 - Draft Emergency Preparedness Frequently Asked Questions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... Commission (NRC) is making available for comment Emergency Preparedness Frequently Asked Question (EPFAQ) No... Library at http://www.nrc.gov/reading-rm/adams.html . To begin the search, select ``ADAMS Public...

  20. Correction: Frequently-Used Words in TV Captions.

    ERIC Educational Resources Information Center

    Jensema, Carl; Rovins, Michele

    1998-01-01

    The 250 most frequently used words in television captions are listed in order of frequency. This table is a correction to the table printed in the article "Instant Reading Incentives: TV Captions," in the September 1997 issue. (DB)

  1. Con: Frequent haemodialysis for all chronic haemodialysis patients.

    PubMed

    Labriola, Laura; Morelle, Johann; Jadoul, Michel

    2015-01-01

    Frequent haemodialysis (HD) regimens have been proposed with the aim to improve survival and other important patient outcomes. They indeed avoid the long interdialytic interval and have been associated with some proven benefits, i.e. an improvement in blood pressure and phosphataemia control, a reduction in left ventricular mass and lower ultrafiltration rates. However, the actual impact of frequent HD regimens on survival is, at best, inconclusive and, at worse, harmful, and remains uncertain regarding nutritional status and anaemia control. Moreover, the higher rates of vascular access complications and more rapid development of anuria with frequent HD regimens are worrying. Frequent HD also considerably increases the burden for patients and their caregivers, logistics and costs, especially with in-centre frequent schedules. In our opinion, before increasing HD frequency, a number of underused strategies summarized in our review and able to improve patient tolerance and/or HD dose should be tested first, taking into account patient's characteristics and life expectancy. Frequent HD schedules should be reserved for selected cases, only after all other available options have failed. PMID:25538159

  2. Delta Coherence Protocols: The Home Update Protocol

    SciTech Connect

    Williams, C.; Reynolds, P.F.; de Supinoki, B.

    2000-07-21

    We describe a new class of directory coherence protocols called delta coherence protocols that use network guarantees to support a new and highly concurrent approach to maintain a consistent shared memory. Delta coherence protocols are more concurrent than other coherence protocols in that they allow processes to pipeline memory accesses without violating sequential consistency; support multiple concurrent readers and writers to the same cache block; and allow processes to access multiple shared variables atomically without invalidating the copies held by other processes or otherwise obtaining exclusive access to the referenced variables. Delta protocols include both update and invalidate protocols. In this paper we describe the simplest, most basic delta protocol, an update protocol called the home update protocol. Delta protocols are based on isotach network guarantees. An isotach network maintains a logical time system that allows each process to predict and control the logical time at which its messages are received. Processes use isotach guarantees to control the logical time at which their requests on shared memory appear to be executed. We prove the home update protocol is correct using logical time to reason about the order in which requests are executed.

  3. Sensorimotor recovery following spaceflight may be due to frequent square-wave saccadic intrusions

    NASA Technical Reports Server (NTRS)

    Reschke, Millard; Somers, Jeffrey T.; Leigh, R. John; Krnavek, Jody M.; Kornilova, Ludmila; Kozlovskaya, Inessa; Bloomberg, Jacob J.; Paloski, William H.

    2004-01-01

    Square-wave jerks (SWJs) are small, involuntary saccades that disrupt steady fixation. We report the case of an astronaut (approximately 140 d on orbit) who showed frequent SWJs, especially postflight, but who showed no impairment of vision or decrement of postflight performance. These data support the view that SWJs do not impair vision because they are paired movements, consisting of a small saccade away from the fixation position followed, within 200 ms, by a corrective saccade that brings the eye back on target. Since many returning astronauts show a decrement of dynamic visual function during postflight locomotion, it seems possible that frequent SWJs improved this astronaut's visual function by providing postsaccadic enhancement of visual fixation, which aided postflight performance. Certainly, frequent SWJs did not impair performance in this astronaut, who had no other neurological disorder.

  4. SUPPORT FOR BEIR VII

    EPA Science Inventory

    The office is supporting the continued funding of National Academy of Sciences Study to update our understanding of the effects of low-level radiation. In particular, this study, entitled the Biological Effects of Ionizing Radiation VII, will draw upon the most recent data avail...

  5. The AGTSR consortium: An update

    SciTech Connect

    Fant, D.B.; Golan, L.P.

    1995-12-31

    The Advanced Gas Turbine Systems Research program is a nationwide consortium dedicated to advancing land-based gas turbine systems for improving future power generation capability. It directly supports the technology-research arm of the ATS program and targets industry- defined research needs in the areas of combustion, heat transfer, materials, aerodynamics, controls, alternative fuels, and advanced cycles. It is organized to enhance U.S. competitiveness through close collaboration with universities, government, and industry at the R&D level. AGTSR is just finishing its third year of operation; it is scheduled to continue past the year 2000. This update reviews the AGTSR triad, which consists of university/industry R&D activities, technology transfer programs, and trial student programs.

  6. Updating Older Fume Hoods.

    ERIC Educational Resources Information Center

    Saunders, G. Thomas

    1985-01-01

    Provides information on updating older fume hoods. Areas addressed include: (1) adjustment of the hood's back baffle; (2) hood air leakage; (3) light level; (4) hood location in relation to room traffic and room air; and (5) establishing and maintaining hood performance. (JN)

  7. Update: Biological Nitrogen Fixation.

    ERIC Educational Resources Information Center

    Wiseman, Alan; And Others

    1985-01-01

    Updates knowledge on nitrogen fixation, indicating that investigation of free-living nitrogen-fixing organisms is proving useful in understanding bacterial partners and is expected to lead to development of more effective symbioses. Specific areas considered include biochemistry/genetics, synthesis control, proteins and enzymes, symbiotic systems,…

  8. Veterinary medicines update.

    PubMed

    2016-03-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:26940413

  9. Veterinary medicines update.

    PubMed

    2016-02-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:26851100

  10. Community Update, 1999.

    ERIC Educational Resources Information Center

    Anderson, Julie, Ed.

    1999-01-01

    This document consists of nine issues (covering January through December 1999) of the newsletter "Community Update," containing articles on community and family involvement in education. Article topics include: new programs to help students prepare for college early; Vice President Al Gore announced the first-ever national Hispanic Education…

  11. Veterinary medicines update.

    PubMed

    2016-07-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:27365238

  12. Veterinary medicines update.

    PubMed

    2016-06-11

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:27288166

  13. Updating: Learning versus Supposing

    ERIC Educational Resources Information Center

    Zhao, Jiaying; Crupi, Vincenzo; Tentori, Katya; Fitelson, Branden; Osherson, Daniel

    2012-01-01

    Bayesian orthodoxy posits a tight relationship between conditional probability and updating. Namely, the probability of an event "A" after learning "B" should equal the conditional probability of "A" given "B" prior to learning "B". We examine whether ordinary judgment conforms to the orthodox view. In three experiments we found substantial…

  14. Supreme Court Update

    ERIC Educational Resources Information Center

    Taylor, Kelley R.

    2009-01-01

    "Chief Justice Flubs Oath." "Justice Ginsburg Has Cancer Surgery." At the start of this year, those were the news headlines about the U.S. Supreme Court. But January 2009 also brought news about key education cases--one resolved and two others on the docket--of which school administrators should take particular note. The Supreme Court updates on…

  15. Cultural practices updates

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cultural practice updates from 2013 included the effects of shredding in spring, residue management, periodic flooding, no-till fertilizer applications, and billet planting on cane tonnage and sugar yield. Shredding, whether high or low, had little impacts in 2013. However, burning following shreddi...

  16. Southern Horticultural Lab Update

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This publication is a new quarterly update for members of the Mississippi Nursery and Landscape Association that is published quarterly in their association newsletter. Two other versions of this newsletter are being submitted to the Louisiana Nursery and Landscape Association (LALNLA) and the Alaba...

  17. Veterinary medicines update.

    PubMed

    2016-09-10

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:27609956

  18. Veterinary medicines update.

    PubMed

    2016-08-01

    The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues. PMID:27493045

  19. Community Update, 2001.

    ERIC Educational Resources Information Center

    Ashby, Nicole, Ed.

    2001-01-01

    This document consists of 10 issues (covering January through December 2000) of the newsletter, "Community Update," which features articles on community and family involvement in education. In addition to the articles, each issue (except the Special Issue) includes a preview of the month's Satellite Town Meeting; events and information discussed…

  20. The Rikers Island Hot Spotters: Defining the Needs of the Most Frequently Incarcerated

    PubMed Central

    Kaba, Fatos; Rosner, Zachary; Vise, Allison; Weiss, David; Brittner, Mindy; Skerker, Molly; Dickey, Nathaniel; Venters, Homer

    2015-01-01

    Objectives. We used “hot spotting” to characterize the persons most frequently admitted to the New York City jail system in 2013. Methods. We used our Correctional Health Services electronic health record to identify 800 patients admitted in 2013 who returned most since November 2008. We compared them to a randomly selected control group of 800 others admitted in 2013, by using descriptive statistics and cross-tabulations, including data through December 2014. Results. The frequently incarcerated individuals had a median of 21 incarcerations (median duration 11 days), representing 18 713 admissions and $129 million in custody and health costs versus $38 million for the controls. The frequently incarcerated were significantly older (42 vs 35 years), and more likely to have serious mental illness (19% vs 8.5%) and homelessness (51.5% vs 14.7%) in their record. Significant substance use was highly prevalent (96.9% vs 55.6%). Most top criminal charges (88.7%) for the frequently incarcerated were misdemeanors; assault charges were less common (2.8% vs 10.4%). Conclusions. Frequently incarcerated persons have chronic mental health and substance use problems, their charges are generally minor, and incarceration is costly. Tailored supportive housing is likely to be less costly and improve outcomes. PMID:26378829

  1. A primer to frequent itemset mining for bioinformatics.

    PubMed

    Naulaerts, Stefan; Meysman, Pieter; Bittremieux, Wout; Vu, Trung Nghia; Vanden Berghe, Wim; Goethals, Bart; Laukens, Kris

    2015-03-01

    Over the past two decades, pattern mining techniques have become an integral part of many bioinformatics solutions. Frequent itemset mining is a popular group of pattern mining techniques designed to identify elements that frequently co-occur. An archetypical example is the identification of products that often end up together in the same shopping basket in supermarket transactions. A number of algorithms have been developed to address variations of this computationally non-trivial problem. Frequent itemset mining techniques are able to efficiently capture the characteristics of (complex) data and succinctly summarize it. Owing to these and other interesting properties, these techniques have proven their value in biological data analysis. Nevertheless, information about the bioinformatics applications of these techniques remains scattered. In this primer, we introduce frequent itemset mining and their derived association rules for life scientists. We give an overview of various algorithms, and illustrate how they can be used in several real-life bioinformatics application domains. We end with a discussion of the future potential and open challenges for frequent itemset mining in the life sciences. PMID:24162173

  2. A primer to frequent itemset mining for bioinformatics

    PubMed Central

    Naulaerts, Stefan; Meysman, Pieter; Bittremieux, Wout; Vu, Trung Nghia; Vanden Berghe, Wim; Goethals, Bart

    2015-01-01

    Over the past two decades, pattern mining techniques have become an integral part of many bioinformatics solutions. Frequent itemset mining is a popular group of pattern mining techniques designed to identify elements that frequently co-occur. An archetypical example is the identification of products that often end up together in the same shopping basket in supermarket transactions. A number of algorithms have been developed to address variations of this computationally non-trivial problem. Frequent itemset mining techniques are able to efficiently capture the characteristics of (complex) data and succinctly summarize it. Owing to these and other interesting properties, these techniques have proven their value in biological data analysis. Nevertheless, information about the bioinformatics applications of these techniques remains scattered. In this primer, we introduce frequent itemset mining and their derived association rules for life scientists. We give an overview of various algorithms, and illustrate how they can be used in several real-life bioinformatics application domains. We end with a discussion of the future potential and open challenges for frequent itemset mining in the life sciences. PMID:24162173

  3. Recommendations of diagnosis and treatment of pleural effusion. Update.

    PubMed

    Villena Garrido, Victoria; Cases Viedma, Enrique; Fernández Villar, Alberto; de Pablo Gafas, Alicia; Pérez Rodríguez, Esteban; Porcel Pérez, José Manuel; Rodríguez Panadero, Francisco; Ruiz Martínez, Carlos; Salvatierra Velázquez, Angel; Valdés Cuadrado, Luis

    2014-06-01

    Although during the last few years there have been several important changes in the diagnostic or therapeutic methods, pleural effusion is still one of the diseases that the respiratory specialist have to evaluate frequently. The aim of this paper is to update the knowledge about pleural effusions, rather than to review the causes of pleural diseases exhaustively. These recommendations have a longer extension for the subjects with a direct clinical usefulness, but a slight update of other pleural diseases has been also included. Among the main scientific advantages are included the thoracic ultrasonography, the intrapleural fibrinolytics, the pleurodesis agents, or the new pleural drainages techniques. PMID:24698396

  4. Frequently Used Coping Scales: A Meta-Analysis.

    PubMed

    Kato, Tsukasa

    2015-10-01

    This article reports the frequency of the use of coping scales in academic journals published from 1998 to 2010. Two thousand empirical journal articles were selected from the EBSCO database. The COPE, Ways of Coping Questionnaire, Coping Strategies Questionnaire, Coping Inventory for Stressful Situations, Religious-COPE and Coping Response Inventory were frequently mentioned. In particular, the COPE (20.2%) and Ways of Coping Questionnaire (13.6%) were used the most frequently. In this literature reviewed, coping scales were most often used to assess coping with health issues (e.g. illness, pain and medical diagnoses) over other types of stressors, and patients were the most frequent participants. Further, alpha coefficients were estimated for the COPE subscales, and correlations between the COPE subscales and coping outcomes were calculated, including depressive symptoms, anxiety, negative affect, psychological distress, physical symptoms and well-being. PMID:24338955

  5. [Anorexia nervosa is frequently associated with psychiatric co-morbidity].

    PubMed

    Panchenko, Anna; Arnfred, Sidse Marie Hemmingsen

    2015-09-21

    Recent literature is explored focusing on the relationship between symptoms of anorexia nervosa (AN) and other psychiatric disorders and lines of treatment. In AN, restrictive subtype, anxiety and obsessive-compulsive disorders are the most frequent co-morbidities. In AN, bulimic subtype, depression, emotional instability/borderline and dependency disorders are most frequent. Psychopharmacological treatment could be tried in cases with AN and co-morbid depression, but otherwise the evidence base is lacking and pharmacological treatment relies on case stories and experience. PMID:26418641

  6. Frequent rhabdomyolysis in anti-NMDA receptor encephalitis.

    PubMed

    Lim, Jung-Ah; Lee, Soon-Tae; Kim, Tae-Joon; Moon, Jangsup; Sunwoo, Jun-Sang; Byun, Jung-Ick; Jung, Keun-Hwa; Jung, Ki-Young; Chu, Kon; Lee, Sang Kun

    2016-09-15

    The aim of this study was to analyze the clinical presentation and provocation factors of rhabdomyolysis in anti-NMDAR encephalitis. Among the 16 patients with anti-NMDAR encephalitis in our institutional cohort, nine patients had elevated CK enzyme levels and clinical evidence of rhabdomyolysis. Rhabdomyolysis was more frequent after immunotherapy. The use of dopamine receptor blocker (DRB) increased the risk of rhabdomyolysis. None of the patients without rhabdomyolysis received DRBs. Rhabdomyolysis is a frequent complication in anti-NMDAR encephalitis and more common after immunotherapy and the use of DRBs increases the risk. Therefore, DRBs should be administered carefully in patients with anti-NMDAR encephalitis. PMID:27609293

  7. Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?

    PubMed

    Sahoo, Jyoti Narayan; Gurjar, Mohan

    2016-02-01

    Phenytoin toxicity or adverse drug reaction is common due to its narrow therapeutic window. Mild and moderate toxicity require supportive care and enteral activated charcoal. In severe toxicity, charcoal hemoperfusion (CHP) have been shown to decrease serum phenytoin half-life and early recovery. Here, we report two cases with phenytoin toxicity who showed marked clinical improvement after early and frequent CHP treatment. PMID:27076716

  8. Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?

    PubMed Central

    Sahoo, Jyoti Narayan; Gurjar, Mohan

    2016-01-01

    Phenytoin toxicity or adverse drug reaction is common due to its narrow therapeutic window. Mild and moderate toxicity require supportive care and enteral activated charcoal. In severe toxicity, charcoal hemoperfusion (CHP) have been shown to decrease serum phenytoin half-life and early recovery. Here, we report two cases with phenytoin toxicity who showed marked clinical improvement after early and frequent CHP treatment. PMID:27076716

  9. Frequent Absences? Help Students Keep up, Not Drop out

    ERIC Educational Resources Information Center

    Butts, Patricia H.

    2009-01-01

    Absenteeism, which is increasing at an alarming rate, is becoming the gateway to dropping out of school altogether. One way to combat this trend is for educators to implement strategies and interventions for students returning from frequent absences in an effort to keep their make-up workload feasible and to help them maintain their grades.…

  10. Demystifying the Electoral College: 12 Frequently Asked Questions

    ERIC Educational Resources Information Center

    Middleton, Tiffany

    2012-01-01

    As the presidential election of 2012 draws closer, Americans will witness a resurgence of references to the Electoral College in news reports. Here, "Looking at the Law" hopes to demystify the Electoral College, and refresh many social studies memories--just in time for the next election--with some frequently asked questions about electing the…

  11. Energy Savings Performance Contracts (ESPC): Frequently Asked Questions

    SciTech Connect

    2012-11-01

    An ESPC is a working relationship between a Federal agency and an energy service company (ESCO). The ESCO conducts a comprehensive energy audit for the Federal facility and identifies improvements to save energy. The following sections present a number of frequently asked questions from ESPC end-users and stakeholders.

  12. Frequently Asked Questions: Common Core State Standards Initiative

    ERIC Educational Resources Information Center

    Common Core State Standards Initiative, 2015

    2015-01-01

    The document provides answers to some of the frequently asked questions about the Common Core State Standards, from how they were developed to what they mean for states and local communities. The questions are organized into the following categories: (1) Overview; (2) Process; (3) Implementation and Future Work; and (4) Content and Quality of the…

  13. Frequent Errors in Chinese EFL Learners' Topic-Based Writings

    ERIC Educational Resources Information Center

    Zhan, Huifang

    2015-01-01

    This paper investigated a large number of errors found in the topic-based writings of Chinese EFL learners, especially provided an analysis on frequent errors, to find useful pedagogical implications for English grammar teaching and writing instruction in Chinese EFL setting. Students' topic-based writings were examined by the author. The findings…

  14. Ban the Book Report: Promoting Frequent and Enthusiastic Reading

    ERIC Educational Resources Information Center

    Foster, Graham

    2012-01-01

    Teachers recognize that frequent independent reading increases student knowledge on a wide range of topics, enhances vocabulary, and improves comprehension. "Ban the Book Report" inspires teachers to go beyond narrow and analytical book reports by exploring the potential of book talks, alternate book covers, identifying features of informational…

  15. The Most Frequently Listed Courses in the Undergraduate Psychology Curriculum.

    ERIC Educational Resources Information Center

    Perlman, Baron; McCann, Lee I.

    1999-01-01

    Explores the most frequently listed undergraduate psychology courses for four institutional types by analyzing 400 college catalogs. Reports that some segmentation continues in the research methodology and developmental areas, the balance of natural and social science courses appear stable, and there are no signs of a change toward vocationalism.…

  16. Vaginal Microbiota of Women with Frequent Vulvovaginal Candidiasis▿

    PubMed Central

    Zhou, Xia; Westman, Rachel; Hickey, Roxana; Hansmann, Melanie A.; Kennedy, Colleen; Osborn, Thomas W.; Forney, Larry J.

    2009-01-01

    Vulvovaginal candidiasis (VVC) is an insidious infection that afflicts a large proportion of women of all ages, and 5 to 8% of affected women experience recurrent VVC (RVVC). The aim of this study was to explore the possible importance of vaginal bacterial communities in reducing the risk of RVVC. The species composition and diversity of microbial communities were evaluated for 42 women with and without frequent VVC based on profiles of terminal restriction fragment polymorphisms of 16S rRNA genes and phylogenetic analysis of cloned 16S rRNA gene sequences from the numerically dominant microbial populations. The data showed that there were no significant differences between the vaginal microbial communities of women in the two groups (likelihood score, 5.948; bootstrap P value, 0.26). Moreover, no novel bacteria were found in the communities of women with frequent VVC. The vaginal communities of most women in both groups (38/42; 90%) were dominated by species of Lactobacillus. The results of this study failed to provide evidence for the existence of altered or unusual vaginal bacterial communities in women who have frequent VVC compared to women who do not have frequent VVC. The findings suggest that commensal vaginal bacterial species may not be able to prevent VVC. PMID:19528218

  17. Hit List: Frequently Challenged Books for Young Adults.

    ERIC Educational Resources Information Center

    Monks, Merri M.; Pistolis, Donna Reidy

    This book presents descriptions of 26 young adult titles that have been frequent targets of censorship attempts. Each entry provides an annotation for the book in question; examples of recent challenges; citations to reviews of the book and background articles; a list of awards garnered by the book or its author; references about the author;…

  18. Fraternity Membership & Frequent Drinking. NBER Working Paper No. 16291

    ERIC Educational Resources Information Center

    DeSimone, Jeffrey S.

    2010-01-01

    Reinforcing earlier findings from other data, college senior fraternity/sorority members are more likely to consume alcohol frequently. Large reductions in estimates upon controlling for time spent partying, and to a lesser extent cigarette use and intramural sports involvement, suggest considerable unobserved heterogeneity in the relationship.…

  19. Can Frequent Moves in Childhood Spell Trouble Later?

    MedlinePlus

    ... England. "Although frequent residential mobility could be a marker for familial psychosocial difficulties, the elevated risks were observed across the socioeconomic spectrum, and mobility may be intrinsically harmful," Webb added. The study included all 1.4 million Danes born between ...

  20. Bumper 3 Update for IADC Protection Manual

    NASA Technical Reports Server (NTRS)

    Christiansen, Eric L.; Nagy, Kornel; Hyde, Jim

    2016-01-01

    The Bumper code has been the standard in use by NASA and contractors to perform meteoroid/debris risk assessments since 1990. It has undergone extensive revisions and updates [NASA JSC HITF website; Christiansen et al., 1992, 1997]. NASA Johnson Space Center (JSC) has applied BUMPER to risk assessments for Space Station, Shuttle, Mir, Extravehicular Mobility Units (EMU) space suits, and other spacecraft (e.g., LDEF, Iridium, TDRS, and Hubble Space Telescope). Bumper continues to be updated with changes in the ballistic limit equations describing failure threshold of various spacecraft components, as well as changes in the meteoroid and debris environment models. Significant efforts are expended to validate Bumper and benchmark it to other meteoroid/debris risk assessment codes. Bumper 3 is a refactored version of Bumper II. The structure of the code was extensively modified to improve maintenance, performance and flexibility. The architecture was changed to separate the frequently updated ballistic limit equations from the relatively stable common core functions of the program. These updates allow NASA to produce specific editions of the Bumper 3 that are tailored for specific customer requirements. The core consists of common code necessary to process the Micrometeoroid and Orbital Debris (MMOD) environment models, assess shadowing and calculate MMOD risk. The library of target response subroutines includes a board range of different types of MMOD shield ballistic limit equations as well as equations describing damage to various spacecraft subsystems or hardware (thermal protection materials, windows, radiators, solar arrays, cables, etc.). The core and library of ballistic response subroutines are maintained under configuration control. A change in the core will affect all editions of the code, whereas a change in one or more of the response subroutines will affect all editions of the code that contain the particular response subroutines which are modified. Note

  1. [Update on anticancer drugs].

    PubMed

    Roila, Fausto; Ballatori, Enzo

    2014-01-01

    Update on anticancer drugs. A thorough review of the clinical trials published over the last two years in major medical and oncological journals on a comprehensive spectrum of oncological conditions aims to provide at the same time (as the authors are well known representatives of the critical and complementary competences of clinical care and research methodology) an interesting double opportunity of update on: a) what is truly (i.e.documented and reliable) innovative and deserves adoption in daily care,vs what is either purely suggestive or clearly misleading; b) what are the methological, concrete, simple rules to observe in a field which is certainly moving fast, but at the same time generates highly controversial behaviors in research as well as in daily practices. The accompanying editorial (pag 60-63) further illustrates the way and the yield of using this material and approach both in the areas of nursing sciences and practice. PMID:25002061

  2. Sensors, Update 12

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Fedder, Gary K.; Korvink, Jan G.

    2003-04-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  3. Sensors, Update 8

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    2001-02-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections: Sensor Technology reviews highlights in applied and basic research, while Sensor Applications covers new or improved applications of sensors, and Sensor Markets provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be invaluable to scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  4. Sensors, Update 2

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    1996-10-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Furthermore, the sensor market as well as peripheral aspects such as standards are covered. Each volume is divided into four sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  5. Sensors, Update 11

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Fedder, Gary K.; Korvink, Jan G.

    2003-03-01

    Sensors Update ensures that you stay at the cutting edge of the field, presenting the current highlights of sensor and related microelectromechanical systems technology. Coverage includes most recent developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles based on micro- and nanotechnology. Each volume is divided into three sections: Sensor Technology reviews highlights in applied and basic research, Sensor Applications covers new or improved applications of sensors and Sensor Markets provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update is of must-have value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  6. Sensors, Update 1

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    1996-12-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Treatments include current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Furthermore, the sensor market as well as peripheral aspects such as standards are covered. Each volume is divided into four sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides an overview of suppliers and market trends for a particular section, and Sensor Standards, reviews recent legislation and requirements for sensors. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  7. Sensors, Update 10

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Fedder, Gary K.; Korvink, Jan G.

    2002-04-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  8. Sensors, Update 9

    NASA Astrophysics Data System (ADS)

    Baltes, Henry; Göpel, Wolfgang; Hesse, Joachim

    2001-10-01

    Sensors Update ensures that you stay at the cutting edge of the field. Built upon the series Sensors, it presents an overview of highlights in the field. Coverage includes current developments in materials, design, production, and applications of sensors, signal detection and processing, as well as new sensing principles. Each volume is divided into three sections. Sensor Technology, reviews highlights in applied and basic research, Sensor Applications, covers new or improved applications of sensors, Sensor Markets, provides a survey of suppliers and market trends for a particular area. With this unique combination of information in each volume, Sensors Update will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users.

  9. SIM-Lite Update

    NASA Technical Reports Server (NTRS)

    Shao, Michael

    2008-01-01

    Discussion focus on: SIM-Lite Instrument Update - 6m baseline, 50cm, approximately 900M cost; Technology Update - Systematic errors and floor; SIM-Lite terrestrial planet discovery capability; Double blind multiple planet study summary; and the changing landscape of exoplanet science and the role of SIM-Lite. Slides include technology to flight component engineering; instrumental systematic errors; ultra deep search for Earth clones; double blind test, astrometric detection of Earths in multiplanet systems; the current era of exoplanet science and where SIM-Lite fits in; the next frontier and where SIM-Lite fits in, why SIM is unique in discovering Earths; imaging planet status is uncertain without masses and ages; SIM role in establishing how planetary systems form and evolve; and SIM probes of broad planet mass range around young stars.

  10. Sequence History Update Tool

    NASA Technical Reports Server (NTRS)

    Khanampompan, Teerapat; Gladden, Roy; Fisher, Forest; DelGuercio, Chris

    2008-01-01

    The Sequence History Update Tool performs Web-based sequence statistics archiving for Mars Reconnaissance Orbiter (MRO). Using a single UNIX command, the software takes advantage of sequencing conventions to automatically extract the needed statistics from multiple files. This information is then used to populate a PHP database, which is then seamlessly formatted into a dynamic Web page. This tool replaces a previous tedious and error-prone process of manually editing HTML code to construct a Web-based table. Because the tool manages all of the statistics gathering and file delivery to and from multiple data sources spread across multiple servers, there is also a considerable time and effort savings. With the use of The Sequence History Update Tool what previously took minutes is now done in less than 30 seconds, and now provides a more accurate archival record of the sequence commanding for MRO.

  11. Update on gastric varices

    PubMed Central

    Triantafyllou, Maria; Stanley, Adrian J

    2014-01-01

    Although less common than oesophageal variceal haemorrhage, gastric variceal bleeding remains a serious complication of portal hypertension, with a high associated mortality. In this review we provide an update on the aetiology, classification and management of gastric varices, including acute bleeding, prevention of rebleeding and primary prophylaxis. We describe the optimum management strategies for gastric varices including drug, endoscopic and radiological therapies, focusing on recent published evidence. PMID:24891929

  12. How Documentalists Update SIMBAD

    NASA Astrophysics Data System (ADS)

    Buga, M.; Bot, C.; Brouty, M.; Bruneau, C.; Brunet, C.; Cambresy, L.; Eisele, A.; Genova, F.; Lesteven, S.; Loup, C.; Neuville, M.; Oberto, A.; Ochsenbein, F.; Perret, E.; Siebert, A.; Son, E.; Vannier, P.; Vollmer, B.; Vonflie, P.; Wenger, M.; Woelfel, F.

    2015-04-01

    The Strasbourg astronomical Data Center (CDS) was created in 1972 and has had a major role in astronomy for more than forty years. CDS develops a service called SIMBAD that provides basic data, cross-identifications, bibliography, and measurements for astronomical objects outside the solar system. It brings to the scientific community an added value to content which is updated daily by a team of documentalists working together in close collaboration with astronomers and IT specialists. We explain how the CDS staff updates SIMBAD with object citations in the main astronomical journals, as well as with astronomical data and measurements. We also explain how the identification is made between the objects found in the literature and those already existing in SIMBAD. We show the steps followed by the documentalist team to update the database using different tools developed at CDS, like the sky visualizer Aladin, and the large catalogues and survey database VizieR. As a direct result of this teamwork, SIMBAD integrates almost 10.000 bibliographic references per year. The service receives more than 400.000 queries per day.

  13. Frequent oligonucleotides and peptides of the Haemophilus influenzae genome.

    PubMed Central

    Karlin, S; Mrázek, J; Campbell, A M

    1996-01-01

    The complete Haemophilus influenzae genome (1.83 Mb, Rd strain) provides opportunities for characterizing global genomic inhomogeneities and for detecting important sequence signals. Along these lines, new methods for identifying frequent words (oligonucleotides and/or peptides) and their distributions are applied to the H.influenzae genome with some comparisons and contrasts made with frequent words of other bacterial genomes. Three major classes of frequent oligonucleotides stand out: (i) oligos related to the familiar uptake signal sequences (USSs), AAGTGCGGT (USS+) and its inverted complement (USS-), (ii) multiple tetranucleotide iterations and (iii) intergenic dyad sequences (ISDs) found as AAGCCCACCCTAC and its dyad form. The USS+ and USS- occur in almost equal counts, are remarkably evenly spaced around the genome, and appear predominantly in the same reading frame of protein coding domains (USS+ translated to Ser-Ala-Val, USS- translated to Thr-Ala-Leu). These observations suggest that USSs contribute to global genomic functions, for example, in replication and/or repair processes, or as membrane attachment sites, or as sequences helping to pack DNA. The long tetranucleotide iterations, virtually unique to H.influenzae (i.e., unknown in other prokaryotes), through polymerase slippage during replication and/or homologous recombination may produce subpopulations expressing alternative proteins. The 13 bp frequent IDS words, invariably intergenic, occur mostly in clusters and provide potential for complex secondary structures suggesting that these sequences may be important signals for regulating the activity of their flanking genes. The frequent oligopeptides of H.influenzae are principally of two kinds--those induced by oligonucleotide frequent words (USSs, tetranucleotide iterations), and those associated with ATP or GTP binding sites that are generally composed of three motifs: the A-box which contributes to delineating the binding pocket; the B-box which

  14. Pharmacodynamics of Memantine: An Update

    PubMed Central

    Rammes, G; Danysz, W; Parsons, C.G

    2008-01-01

    Memantine received marketing authorization from the European Agency for the Evaluation of Medicinal Products (EMEA) for the treatment of moderately severe to severe Alzheimer´s disease (AD) in Europe on 17th May 2002 and shortly thereafter was also approved by the FDA for use in the same indication in the USA. Memantine is a moderate affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist with strong voltage-dependency and fast kinetics. Due to this mechanism of action (MOA), there is a wealth of other possible therapeutic indications for memantine and numerous preclinical data in animal models support this assumption. This review is intended to provide an update on preclinical studies on the pharmacodynamics of memantine, with an additional focus on animal models of diseases aside from the approved indication. For most studies prior to 1999, the reader is referred to a previous review [196]. In general, since 1999, considerable additional preclinical evidence has accumulated supporting the use of memantine in AD (both symptomatic and neuroprotective). In addition, there has been further confirmation of the MOA of memantine as an uncompetitive NMDA receptor antagonist and essentially no data contradicting our understanding of the benign side effect profile of memantine. PMID:19305788

  15. Factors associated with frequent and infrequent HIV testing.

    PubMed

    Brown, B S; O'Grady, K E; Farrell, E V; Flechner, I S; Nurco, D N

    2001-10-01

    Drug user treatment clients with 5 or more HIV tests (frequent testees N=43) and 0-2 HIV tests (infrequent testees-N = 56) were compared on demographic characteristics, risk behaviors, perceived risk of HIV infection to self, involvement with family members, and psychological functioning. Extreme groups of HIV testees did not differ on any variables other than an index of perceived vulnerability to HIV infection (e.g., " You think that you really could get AIDS"). That measure of felt vulnerability was not correlated significantly with needle or sexual risk behaviors, family involvement, psychological functioning or other measures of perceived risk. It was reasoned that, in a community in which both dangers and protective behaviors are widely understood, frequent testees experience a generalized and heightened concern unrelated to specific behaviors or characteristics. PMID:11758815

  16. Evidence for frequent incest in a cooperatively breeding mammal.

    PubMed

    Nichols, H J; Cant, M A; Hoffman, J I; Sanderson, J L

    2014-12-01

    As breeding between relatives often results in inbreeding depression, inbreeding avoidance is widespread in the animal kingdom. However, inbreeding avoidance may entail fitness costs. For example, dispersal away from relatives may reduce survival. How these conflicting selection pressures are resolved is challenging to investigate, but theoretical models predict that inbreeding should occur frequently in some systems. Despite this, few studies have found evidence of regular incest in mammals, even in social species where relatives are spatio-temporally clustered and opportunities for inbreeding frequently arise. We used genetic parentage assignments together with relatedness data to quantify inbreeding rates in a wild population of banded mongooses, a cooperatively breeding carnivore. We show that females regularly conceive to close relatives, including fathers and brothers. We suggest that the costs of inbreeding avoidance may sometimes outweigh the benefits, even in cooperatively breeding species where strong within-group incest avoidance is considered to be the norm. PMID:25540153

  17. Evidence for frequent incest in a cooperatively breeding mammal

    PubMed Central

    Nichols, H. J.; Cant, M. A.; Hoffman, J. I.; Sanderson, J. L.

    2014-01-01

    As breeding between relatives often results in inbreeding depression, inbreeding avoidance is widespread in the animal kingdom. However, inbreeding avoidance may entail fitness costs. For example, dispersal away from relatives may reduce survival. How these conflicting selection pressures are resolved is challenging to investigate, but theoretical models predict that inbreeding should occur frequently in some systems. Despite this, few studies have found evidence of regular incest in mammals, even in social species where relatives are spatio-temporally clustered and opportunities for inbreeding frequently arise. We used genetic parentage assignments together with relatedness data to quantify inbreeding rates in a wild population of banded mongooses, a cooperatively breeding carnivore. We show that females regularly conceive to close relatives, including fathers and brothers. We suggest that the costs of inbreeding avoidance may sometimes outweigh the benefits, even in cooperatively breeding species where strong within-group incest avoidance is considered to be the norm. PMID:25540153

  18. In Search of Social Translucence: An Audit Log Analysis of Handoff Documentation Views and Updates

    PubMed Central

    Jiang, Silis Y.; Hum, R. Stanley; Vawdrey, David; Mamykina, Lena

    2015-01-01

    Communication and information sharing are critical parts of teamwork in the hospital; however, achieving open and fluid communication can be challenging. Finding specific patient information within documentation can be difficult. Recent studies on handoff documentation tools show that resident handoff notes are increasingly used as an alternative information source by non-physician clinicians. Previous findings also show that residents have become aware of this unintended use. This study investigated the alignment of resident note updating patterns and team note viewing patterns based on usage log data of handoff notes. Qualitative interviews with clinicians were used to triangulate findings based on the log analysis. The study found that notes that were frequently updated were viewed significantly more frequently than notes updated less often (p < 2.2 × 10−16). Almost 44% of all notes had aligned frequency of views and updates. The considerable percentage (56%) of mismatched note utilization suggests an opportunity for improvement. PMID:26958202

  19. Frequent DPH3 promoter mutations in skin cancers

    PubMed Central

    Denisova, Evgeniya; Heidenreich, Barbara; Nagore, Eduardo; Rachakonda, P. Sivaramakrishna; Hosen, Ismail; Akrap, Ivana; Traves, Víctor; García-Casado, Zaida; López-Guerrero, José Antonio; Requena, Celia; Sanmartin, Onofre; Serra-Guillén, Carlos; Llombart, Beatriz; Guillén, Carlos; Ferrando, Jose; Gimeno, Enrique; Nordheim, Alfred; Hemminki, Kari; Kumar, Rajiv

    2015-01-01

    Recent reports suggested frequent occurrence of cancer associated somatic mutations within regulatory elements of the genome. Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. The UV-signature mutations occurred at sites adjacent and within a binding motif for E-twenty six/ternary complex factors (Ets/TCF), at −8 and −9 bp from DPH3 transcription start site. Follow up screening of 586 different skin lesions showed that the DPH3 promoter mutations were present in melanocytic nevi (2/114; 2%), melanoma (30/304; 10%), basal cell carcinoma of skin (BCC; 57/137; 42%) and squamous cell carcinoma of skin (SCC; 12/31; 39%). Reporter assays carried out in one melanoma cell line for DPH3 and OXNAD1 orientations showed statistically significant increased promoter activity due to −8/−9CC > TT tandem mutations; although, no effect of the mutations on DPH3 and OXNAD1 transcription in tumors was observed. The results from this study show occurrence of frequent somatic non-coding mutations adjacent to a pre-existing binding site for Ets transcription factors within the directional promoter of DPH3 and OXNAD1 genes in three major skin cancers. The detected mutations displayed typical UV signature; however, the functionality of the mutations remains to be determined. PMID:26416425

  20. Frequent DPH3 promoter mutations in skin cancers.

    PubMed

    Denisova, Evgeniya; Heidenreich, Barbara; Nagore, Eduardo; Rachakonda, P Sivaramakrishna; Hosen, Ismail; Akrap, Ivana; Traves, Víctor; García-Casado, Zaida; López-Guerrero, José Antonio; Requena, Celia; Sanmartin, Onofre; Serra-Guillén, Carlos; Llombart, Beatriz; Guillén, Carlos; Ferrando, Jose; Gimeno, Enrique; Nordheim, Alfred; Hemminki, Kari; Kumar, Rajiv

    2015-11-01

    Recent reports suggested frequent occurrence of cancer associated somatic mutations within regulatory elements of the genome. Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. The UV-signature mutations occurred at sites adjacent and within a binding motif for E-twenty six/ternary complex factors (Ets/TCF), at -8 and -9 bp from DPH3 transcription start site. Follow up screening of 586 different skin lesions showed that the DPH3 promoter mutations were present in melanocytic nevi (2/114; 2%), melanoma (30/304; 10%), basal cell carcinoma of skin (BCC; 57/137; 42%) and squamous cell carcinoma of skin (SCC; 12/31; 39%). Reporter assays carried out in one melanoma cell line for DPH3 and OXNAD1 orientations showed statistically significant increased promoter activity due to -8/-9CC > TT tandem mutations; although, no effect of the mutations on DPH3 and OXNAD1 transcription in tumors was observed. The results from this study show occurrence of frequent somatic non-coding mutations adjacent to a pre-existing binding site for Ets transcription factors within the directional promoter of DPH3 and OXNAD1 genes in three major skin cancers. The detected mutations displayed typical UV signature; however, the functionality of the mutations remains to be determined. PMID:26416425

  1. Handling Dynamic Weights in Weighted Frequent Pattern Mining

    NASA Astrophysics Data System (ADS)

    Ahmed, Chowdhury Farhan; Tanbeer, Syed Khairuzzaman; Jeong, Byeong-Soo; Lee, Young-Koo

    Even though weighted frequent pattern (WFP) mining is more effective than traditional frequent pattern mining because it can consider different semantic significances (weights) of items, existing WFP algorithms assume that each item has a fixed weight. But in real world scenarios, the weight (price or significance) of an item can vary with time. Reflecting these changes in item weight is necessary in several mining applications, such as retail market data analysis and web click stream analysis. In this paper, we introduce the concept of a dynamic weight for each item, and propose an algorithm, DWFPM (dynamic weighted frequent pattern mining), that makes use of this concept. Our algorithm can address situations where the weight (price or significance) of an item varies dynamically. It exploits a pattern growth mining technique to avoid the level-wise candidate set generation-and-test methodology. Furthermore, it requires only one database scan, so it is eligible for use in stream data mining. An extensive performance analysis shows that our algorithm is efficient and scalable for WFP mining using dynamic weights.

  2. Frequent dieting among adolescents: psychosocial and health behavior correlates.

    PubMed Central

    French, S A; Story, M; Downes, B; Resnick, M D; Blum, R W

    1995-01-01

    OBJECTIVES. The present study examined correlates of frequent dieting in 33,393 adolescents. It was hypothesized that frequent dieting would be correlated with negative psychosocial and health behavior outcomes. METHODS. A comprehensive, school-based health behavior survey was administered in 1987 to public school students in grades 7 through 12 in Minnesota. Students self-reported dieting behavior; substance use; suicidal, sexual, and delinquent behavior; family and peer concerns; sick days; and abuse history. Differences on psychosocial and health behavior risk factors by dieting frequency and by purging status were assessed with multivariate logistic regression, with body mass index and demographic variables controlled. RESULTS. Dieting frequency was associated with history of binge eating (females: odds ratio [OR] = 1.46, males: OR = 1.53); poor body image (females: OR = 0.56, males: OR = 0.63); lower connectedness to others (females: OR = 0.79); greater alcohol use (females: OR = 1.17); and greater tobacco use (females: OR = 1.08). Purging status was independently associated with negative risk factors in both males and females. CONCLUSIONS. These findings suggest that frequent dieting efforts in adolescents should not be viewed in isolation, but rather in the broader context of health and risk-taking behaviors. PMID:7733431

  3. Prediction of Risk Factors of Frequent Relapse Idiopathic Nephrotic Syndrome.

    PubMed

    Jahan, I; Hanif, M; Ali, M A; Hoque, M M

    2015-10-01

    This case control study was aimed to identify the predictive risk factors for frequent relapse idiopathic nephrotic syndrome (INS) and conducted in Sir Salimullah Medical College & Mitford Hospital, Dhaka and at Renal and Dialysis Unit of Dhaka Shishu Hospital and Bangladesh Institute of Child Health (BICH), Dhaka, from January 2006 to December 2006. We examined retrospectively the clinical course of fifty cases of frequent relapse nephrotic syndrome (FRNS) as cases and fifty cases of infrequent relapse nephrotic syndrome (IRNS) as control who met the predefined enrollment criteria, followed for at least one year after initial onset of disease. After enrollment following parameters were studied as predictors of frequent relapse: i) Socio-demographic variables: age, sex, socio-economic condition, number of living room ii) Disease related variables i.e. age of onset, duration of illness, frequency of relapse within the 1st year, regimen of initial steroid therapy, total cumulative dose of steroid for remission, day of remission after starting steroid, association with atopy and infection, concomitant upper respiratory illness iii) Biochemical and pathological variables (at the time of initial attack) i.e. Serum albumin, serum cholesterol, blood urea, 24 hours urinary protein, serum creatinine, complete blood count, urine RBC, urine pus cell, urine culture. The test statistics used to analyses the data were descriptive statistics, Chi-square probability test, Student's t-test and Binary logistic regression analysis for Odds ratio. Both univariate and multivariate logistic regression analysis revealed that age of onset (P<0.001, OR=0.9, 95% CI=0.85-0.95), poor socioeconomic status (P<0.034, OR=0.5.8, 95% CI=1.14-29.5) and low serum albumin level at the time of initial presentation (P<0.022, OR=0.8, 95% CI=0.65-0.97) were independent predictors of frequent relapse nephrotic syndrome. In conclusion, we demonstrated that age at onset, poor socioeconomic condition and low

  4. [FREQUENTLY USED VEGETABLE OILS IN SOUTH AMERICA: FEATURES AND PROPERTIES].

    PubMed

    Durán Agüero, Samuel; Torres García, Jairo; Sanhueza Catalán, Julio

    2015-01-01

    In recent decades, the consumption of vegetable oils has increased in our society, being an important part of the diet worldwide. South America is a major producer of an important variety of vegetable oils. The composition of vegetable oils is not standard as it varies greatly in the amount of saturated, monounsaturated and polyunsaturated fatty acids, and particularly in the amounts of omega-6 and omega-3, which are associated with the source either plant species, seed, plant or fruit, providing different nutritional benefits. The purpose of this article is to review and update the data and evidence about the consumption of oils produced and commercialized in South America, such as soybean oil, corn, palm, sunflower, canola and olive oils, and also to determine health effects from studies related with the topic. PMID:26262691

  5. Fuel Cell Handbook update

    SciTech Connect

    Owens, W.R.; Hirschenhofer, J.H.; Engleman, R.R. Jr.; Stauffer, D.B.

    1993-11-01

    The objective of this work was to update the 1988 version of DOE`s Fuel Cell Handbook. Significant developments in the various fuel cell technologies required revisions to reflect state-of-the-art configurations and performance. The theoretical presentation was refined in order to make the handbook more useful to both the casual reader and fuel cell or systems analyst. In order to further emphasize the practical application of fuel cell technologies, the system integration information was expanded. In addition, practical elements, such as suggestions and guidelines to approximate fuel cell performance, were provided.

  6. Updated Conceptual Cost Estimating

    NASA Technical Reports Server (NTRS)

    Brown, J. A.

    1987-01-01

    16-page report discusses development and use of NASA TR-1508, the Kennedy Space Center Aerospace Construction Price Book for preparing conceptual, budget, funding, cost-estimating, and preliminary cost-engineering reports. Updated annually from 1974 through 1985 with actual bid prices and government estimates. Includes labor and material quantities and prices with contractor and subcontractor markups for buildings, facilities, and systems at Kennedy Space Center. While data pertains to aerospace facilities, format and cost-estimating techniques guide estimation of costs in other construction applications.

  7. Fuel Cell Handbook update

    NASA Astrophysics Data System (ADS)

    Owens, W. R.; Hirschenhofer, J. H.; Engleman, R. R., Jr.; Stauffer, D. B.

    The objective of this work was to update the 1988 version of DOE's Fuel Cell Handbook. Significant developments in the various fuel cell technologies required revisions to reflect state-of-the-art configurations and performance. The theoretical presentation was refined in order to make the handbook more useful to both the casual reader and fuel cell or systems analyst. In order to further emphasize the practical application of fuel cell technologies, the system integration information was expanded. In addition, practical elements, such as suggestions and guidelines to approximate fuel cell performance, were provided.

  8. Development of the updated system of city underground pipelines based on Visual Studio

    NASA Astrophysics Data System (ADS)

    Zhang, Jianxiong; Zhu, Yun; Li, Xiangdong

    2009-10-01

    Our city has owned the integrated pipeline network management system with ArcGIS Engine 9.1 as the bottom development platform and with Oracle9i as basic database for storaging data. In this system, ArcGIS SDE9.1 is applied as the spatial data engine, and the system was a synthetic management software developed with Visual Studio visualization procedures development tools. As the pipeline update function of the system has the phenomenon of slower update and even sometimes the data lost, to ensure the underground pipeline data can real-time be updated conveniently and frequently, and the actuality and integrity of the underground pipeline data, we have increased a new update module in the system developed and researched by ourselves. The module has the powerful data update function, and can realize the function of inputting and outputting and rapid update volume of data. The new developed module adopts Visual Studio visualization procedures development tools, and uses access as the basic database to storage data. We can edit the graphics in AutoCAD software, and realize the database update using link between the graphics and the system. Practice shows that the update module has good compatibility with the original system, reliable and high update efficient of the database.

  9. Electrophysiological correlates of inter- and intrahemispheric saccade-related updating of visual space.

    PubMed

    Peterburs, Jutta; Gajda, Kathrin; Hoffmann, Klaus-Peter; Daum, Irene; Bellebaum, Christian

    2011-01-20

    The process of spatial updating is crucial for maintaining perceptual stability despite gross and frequent displacements of space following saccadic eye movements. Efference copies of motor commands are used to update retinal coordinates across saccades. The present study investigated neural correlates of saccadic updating in a perceptual context with regard to temporal dynamics and modulation by intra- versus interhemispheric transfer of updating-related information. Twenty-two subjects engaged in a perceptual localization task which required trans-saccadic spatial updating while event-related potentials (ERPs) were recorded. In accordance with previous studies, post-saccadic perceptual localization of stimuli presented before a saccade was less accurate when relying on efference copy signals (i.e. updating was required) as compared to a control condition not involving updating. Updating-related ERP components emerged before and after saccade onset. There was no clear transfer-dependent modulation of the presaccadic component. A negative deflection between 30 and 70 ms after saccade onset was most pronounced for rightward saccades, and when intrahemispheric transfer was required. A slower positive deflection starting about 170-230 ms after saccade onset had a shorter latency for leftward than for rightward saccades and was not modulated by transfer. In accordance with previous work, this relative positivity is thought to reflect sensory memory, whereas the earlier negative deflection can be more directly linked to the updating process itself. PMID:20797412

  10. Genomic aberrations frequently alter chromatin regulatory genes in chordoma.

    PubMed

    Wang, Lu; Zehir, Ahmet; Nafa, Khedoudja; Zhou, Nengyi; Berger, Michael F; Casanova, Jacklyn; Sadowska, Justyna; Lu, Chao; Allis, C David; Gounder, Mrinal; Chandhanayingyong, Chandhanarat; Ladanyi, Marc; Boland, Patrick J; Hameed, Meera

    2016-07-01

    Chordoma is a rare primary bone neoplasm that is resistant to standard chemotherapies. Despite aggressive surgical management, local recurrence and metastasis is not uncommon. To identify the specific genetic aberrations that play key roles in chordoma pathogenesis, we utilized a genome-wide high-resolution SNP-array and next generation sequencing (NGS)-based molecular profiling platform to study 24 patient samples with typical histopathologic features of chordoma. Matching normal tissues were available for 16 samples. SNP-array analysis revealed nonrandom copy number losses across the genome, frequently involving 3, 9p, 1p, 14, 10, and 13. In contrast, copy number gain is uncommon in chordomas. Two minimum deleted regions were observed on 3p within a ∼8 Mb segment at 3p21.1-p21.31, which overlaps SETD2, BAP1 and PBRM1. The minimum deleted region on 9p was mapped to CDKN2A locus at 9p21.3, and homozygous deletion of CDKN2A was detected in 5/22 chordomas (∼23%). NGS-based molecular profiling demonstrated an extremely low level of mutation rate in chordomas, with an average of 0.5 mutations per sample for the 16 cases with matched normal. When the mutated genes were grouped based on molecular functions, many of the mutation events (∼40%) were found in chromatin regulatory genes. The combined copy number and mutation profiling revealed that SETD2 is the single gene affected most frequently in chordomas, either by deletion or by mutations. Our study demonstrated that chordoma belongs to the C-class (copy number changes) tumors whose oncogenic signature is non-random multiple copy number losses across the genome and genomic aberrations frequently alter chromatin regulatory genes. © 2016 Wiley Periodicals, Inc. PMID:27072194

  11. Obsessive-Compulsive Disorder Presenting with Compulsions to Urinate Frequently.

    PubMed

    Jiwanmall, Stephen Amarjeet; Kattula, Dheeraj

    2016-01-01

    Obsessive compulsive disorder (OCD) is a common psychiatric disorder which is easily recognized. However, sometimes patients of OCD present in such an atypical presentation of symptoms and a pathway to care involving multiple specialities. We report a case of a girl who had consulted several physicians and a urologist for frequent micturition, who was treated as a case of OCD after clarifying the compulsive nature of her symptom. There was significant improvement in her condition following 8 weeks of treatment with 200 mg of Sertraline and behaviour therapy. PMID:27570353

  12. Obsessive-Compulsive Disorder Presenting with Compulsions to Urinate Frequently

    PubMed Central

    Jiwanmall, Stephen Amarjeet; Kattula, Dheeraj

    2016-01-01

    Obsessive compulsive disorder (OCD) is a common psychiatric disorder which is easily recognized. However, sometimes patients of OCD present in such an atypical presentation of symptoms and a pathway to care involving multiple specialities. We report a case of a girl who had consulted several physicians and a urologist for frequent micturition, who was treated as a case of OCD after clarifying the compulsive nature of her symptom. There was significant improvement in her condition following 8 weeks of treatment with 200 mg of Sertraline and behaviour therapy. PMID:27570353

  13. Retention Indices for Frequently Reported Compounds of Plant Essential Oils

    NASA Astrophysics Data System (ADS)

    Babushok, V. I.; Linstrom, P. J.; Zenkevich, I. G.

    2011-12-01

    Gas chromatographic retention indices were evaluated for 505 frequently reported plant essential oil components using a large retention index database. Retention data are presented for three types of commonly used stationary phases: dimethyl silicone (nonpolar), dimethyl silicone with 5% phenyl groups (slightly polar), and polyethylene glycol (polar) stationary phases. The evaluations are based on the treatment of multiple measurements with the number of data records ranging from about 5 to 800 per compound. Data analysis was limited to temperature programmed conditions. The data reported include the average and median values of retention index with standard deviations and confidence intervals.

  14. Do short, frequent DNA sequence motifs mould the epigenome?

    PubMed

    Quante, Timo; Bird, Adrian

    2016-04-01

    'Epigenome' refers to the panoply of chemical modifications borne by DNA and its associated proteins that locally affect genome function. Epigenomic patterns are thought to be determined by external constraints resulting from development, disease and the environment, but DNA sequence is also a potential influence. We propose that domains of relatively uniform DNA base composition may modulate the epigenome through cell type-specific proteins that recognize short, frequent sequence motifs. Differential recruitment of epigenomic modifiers may adjust gene expression in multigene blocks as an alternative to tuning the activity of each gene separately, thus simplifying gene expression programming. PMID:26837845

  15. Working Memory Updating Latency Reflects the Cost of Switching between Maintenance and Updating Modes of Operation

    ERIC Educational Resources Information Center

    Kessler, Yoav; Oberauer, Klaus

    2014-01-01

    Updating and maintenance of information are 2 conflicting demands on working memory (WM). We examined the time required to update WM (updating latency) as a function of the sequence of updated and not-updated items within a list. Participants held a list of items in WM and updated a variable subset of them in each trial. Four experiments that vary…

  16. Getting into hot water: sick guppies frequent warmer thermal conditions.

    PubMed

    Mohammed, Ryan S; Reynolds, Michael; James, Joanna; Williams, Chris; Mohammed, Azad; Ramsubhag, Adesh; van Oosterhout, Cock; Cable, Jo

    2016-07-01

    Ectotherms depend on the environmental temperature for thermoregulation and exploit thermal regimes that optimise physiological functioning. They may also frequent warmer conditions to up-regulate their immune response against parasite infection and/or impede parasite development. This adaptive response, known as 'behavioural fever', has been documented in various taxa including insects, reptiles and fish, but only in response to endoparasite infections. Here, a choice chamber experiment was used to investigate the thermal preferences of a tropical freshwater fish, the Trinidadian guppy (Poecilia reticulata), when infected with a common helminth ectoparasite Gyrodactylus turnbulli, in female-only and mixed-sex shoals. The temperature tolerance of G. turnbulli was also investigated by monitoring parasite population trajectories on guppies maintained at a continuous 18, 24 or 32 °C. Regardless of shoal composition, infected fish frequented the 32 °C choice chamber more often than when uninfected, significantly increasing their mean temperature preference. Parasites maintained continuously at 32 °C decreased to extinction within 3 days, whereas mean parasite abundance increased on hosts incubated at 18 and 24 °C. We show for the first time that gyrodactylid-infected fish have a preference for warmer waters and speculate that sick fish exploit the upper thermal tolerances of their parasites to self medicate. PMID:26965895

  17. Analyzing the Number of Varieties in Frequently Found Flows

    NASA Astrophysics Data System (ADS)

    Shomura, Yusuke; Watanabe, Yoshinori; Yoshida, Kenichi

    Abnormal traffic that causes various problems on the Internet, such as P2P flows, DDoS attacks, and Internet worms, is increasing; therefore, the importance of methods that identify and control abnormal traffic is also increasing. Though the application of frequent-itemset-mining techniques is a promising way to analyze Internet traffic, the huge amount of data on the Internet prevents such techniques from being effective. To overcome this problem, we have developed a simple frequent-itemset-mining method that uses only a small amount of memory but is effective even with the large volumes of data associated with broadband Internet traffic. Using our method also involves analyzing the number of distinct elements in the itemsets found, which helps identify abnormal traffic. We used a cache-based implementation of our method to analyze actual data on the Internet and demonstrated that such an implementation can be used to provide on-line analysis of data while using only a small amount of memory.

  18. Parapharyngeal abscess is frequently associated with concomitant peritonsillar abscess.

    PubMed

    Klug, Tejs Ehlers; Fischer, Anne Sophie Lind; Antonsen, Christine; Rusan, Maria; Eskildsen, Helle; Ovesen, Therese

    2014-06-01

    To characterize patients with parapharyngeal abscess admitted to a Danish tertiary care centre and evaluate our management. This is a retrospective chart review. All records of patients with parapharyngeal abscess admitted to the Ear-Nose-Throat Department at Aarhus University Hospital, Denmark, from January 2001 through December 2011 were reviewed. In total, 63 patients (41 males), aged 4-89 years (median, 45 years) were included in the study. The mean annual incidence of parapharyngeal abscess was 0.9 cases/100,000 population. Thirty-three (52%) patients had concomitant peritonsillar abscess. In two patients the parapharyngeal abscess was accompanied by necrotizing fasciitis. The most frequent surgical approach used was intrapharyngeal incision in combination with tonsillectomy. The most commonly used antibiotic regimen was benzylpenicillin plus metronidazole. Seven (13%) patients returned to the operating theatre due to post-tonsillectomy haemorrhage or insufficient abscess drainage. Tonsillectomy and internal incision of the abscess in combination with a narrow-spectrum intravenous penicillin and metronidazole is a safe and efficient approach for managing parapharyngeal abscesses. This approach, however, carries a relatively high complication rate, requiring close surveillance in the early post-operative period. This is especially true for parapharyngeal abscess patients without peritonsillar abscess. In our series, these patients were more ill, more likely to experience complications, require intensive care, intubation, and tracheotomy, than parapharyngeal abscess patients with concurrent peritonsillar abscess. The frequent co-existence of parapharyngeal abscess and peritonsillar abscess favours careful consideration of addition of tonsillectomy to intrapharyngeal incision. PMID:23982668

  19. Widespread and frequent horizontal transfers of transposable elements in plants.

    PubMed

    El Baidouri, Moaine; Carpentier, Marie-Christine; Cooke, Richard; Gao, Dongying; Lasserre, Eric; Llauro, Christel; Mirouze, Marie; Picault, Nathalie; Jackson, Scott A; Panaud, Olivier

    2014-05-01

    Vertical, transgenerational transmission of genetic material occurs through reproduction of living organisms. In addition to vertical inheritance, horizontal gene transfer between reproductively isolated species has recently been shown to be an important, if not dominant, mechanism in the evolution of prokaryotic genomes. In contrast, only a few horizontal transfer (HT) events have been characterized so far in eukaryotes and mainly concern transposable elements (TEs). Whether these are frequent and have a significant impact on genome evolution remains largely unknown. We performed a computational search for highly conserved LTR retrotransposons among 40 sequenced eukaryotic genomes representing the major plant families. We found that 26 genomes (65%) harbor at least one case of horizontal TE transfer (HTT). These transfers concern species as distantly related as palm and grapevine, tomato and bean, or poplar and peach. In total, we identified 32 cases of HTTs, which could translate into more than 2 million among the 13,551 monocot and dicot genera. Moreover, we show that these TEs have remained functional after their transfer, occasionally causing a transpositional burst. This suggests that plants can frequently exchange genetic material through horizontal transfers and that this mechanism may be important in TE-driven genome evolution. PMID:24518071

  20. Common Pharmacophore Identification Using Frequent Clique Detection Algorithm

    PubMed Central

    Podolyan, Yevgeniy; Karypis, George

    2008-01-01

    The knowledge of a pharmacophore, or the 3D arrangement of features in the biologically active molecule that is responsible for its pharmacological activity, can help in the search and design of a new or better drug acting upon the same or related target. In this paper we describe two new algorithms based on the frequent clique detection in the molecular graphs. The first algorithm mines all frequent cliques that are present in at least one of the conformers of each (or a portion of all) molecules. The second algorithm exploits the similarities among the different conformers of the same molecule and achieves an order of magnitude performance speedup compared to the first algorithm. Both algorithms are guaranteed to find all common pharmacophores in the dataset, which is confirmed by the validation on the set of molecules for which pharmacophores have been determined experimentally. In addition, these algorithms are able to scale to datasets with arbitrarily large number of conformers per molecule and identify multiple ligand binding modes or multiple binding sites of the target. PMID:19072298

  1. Receptor Editing Occurs Frequently during Normal B Cell Development

    PubMed Central

    Retter, Marc W.; Nemazee, David

    1998-01-01

    Allelic exclusion is established in development through a feedback mechanism in which the assembled immunoglobulin (Ig) suppresses further V(D)J rearrangement. But Ig expression sometimes fails to prevent further rearrangement. In autoantibody transgenic mice, reactivity of immature B cells with autoantigen can induce receptor editing, in which allelic exclusion is transiently prevented or reversed through nested light chain gene rearrangement, often resulting in altered B cell receptor specificity. To determine the extent of receptor editing in a normal, non-Ig transgenic immune system, we took advantage of the fact that λ light chain genes usually rearrange after κ genes. This allowed us to analyze κ loci in IgMλ+ cells to determine how frequently in-frame κ genes fail to suppress λ gene rearrangements. To do this, we analyzed recombined VκJκ genes inactivated by subsequent recombining sequence (RS) rearrangement. RS rearrangements delete portions of the κ locus by a V(D)J recombinase-dependent mechanism, suggesting that they play a role in receptor editing. We show that RS recombination is frequently induced by, and inactivates, functionally rearranged κ loci, as nearly half (47%) of the RS-inactivated VκJκ joins were in-frame. These findings suggest that receptor editing occurs at a surprisingly high frequency in normal B cells. PMID:9763602

  2. Stormwater harvesting and WSUD frequent flow management: a compatibility analysis.

    PubMed

    Brodie, I

    2012-01-01

    Harvesting stormwater from urban catchments provides a supplementary water resource and, due to the physical abstraction of polluted water, also leads to environmental benefits. These benefits include the reduction of frequent ecosystem disturbance during small storms and less waterway erosion; hydrological impacts which are currently addressed by Water Sensitive Urban Design guidelines for stormwater frequent flow management (FFM). Although FFM and stormwater harvesting share the same store-release behaviour, they have a very different underlying basis to their design and operation. This paper explores the level of compatibility between these two systems and hence the potential for their integration. It was found by water balance analysis that the harvesting storage required to maximise most yields is similar to the recommended storage volume for FFM. This analysis was performed for a temperate-climate location in South East Queensland under historically low rainfalls. Environmental benefits associated with runoff quantity and pollutant load reductions are highest when the capture storage is rapidly emptied after storms. PMID:22744693

  3. Infant and perinatal pulmonary hypoplasia frequently associated with brainstem hypodevelopment.

    PubMed

    Ottaviani, Giulia; Mingrone, Rosaria; Lavezzi, Anna M; Matturri, Luigi

    2009-04-01

    Recent anatomo-pathological studies have revealed a frequent associated hypoplasia of both arcuate nucleus and lungs in stillbirths. The purpose of this study is to analyze the lung and brainstem development in sudden unexplained perinatal death and sudden infant death syndrome (SIDS). A total of 51 cases were investigated. A complete autopsy was performed in each case. Anatomo-pathologic examination of the central autonomic nervous system included an in-depth study on histological serial sections of the brains where the main structures participating in control of the vital functions are located. The stage of lung development was evaluated by macroscopic and microscopic criteria. In 52.9% of cases, a pulmonary hypoplasia was detected. The pulmonary hypoplasia was significantly more frequent in the SIDS group compared to the sudden perinatal unexplained death groups (p < 0.05). In 72.5% of cases, histological examination of the brainstem on serial sections showed hypodevelopment of the brainstem nuclei, particularly hypoplasia, of the arcuate nucleus (60.8%). In 47.1% of cases, pulmonary hypoplasia was associated with brainstem hypodevelopment. PMID:19288128

  4. Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.

    PubMed

    Devine, Shane M; Mulcair, Mark D; Debono, Cael O; Leung, Eleanor W W; Nissink, J Willem M; Lim, San Sui; Chandrashekaran, Indu R; Vazirani, Mansha; Mohanty, Biswaranjan; Simpson, Jamie S; Baell, Jonathan B; Scammells, Peter J; Norton, Raymond S; Scanlon, Martin J

    2015-02-12

    We have identified a class of molecules, known as 2-aminothiazoles (2-ATs), as frequent-hitting fragments in biophysical binding assays. This was exemplified by 4-phenylthiazol-2-amine being identified as a hit in 14/14 screens against a diverse range of protein targets, suggesting that this scaffold is a poor starting point for fragment-based drug discovery. This prompted us to analyze this scaffold in the context of an academic fragment library used for fragment-based drug discovery (FBDD) and two larger compound libraries used for high-throughput screening (HTS). This analysis revealed that such "promiscuous 2-aminothiazoles" (PrATs) behaved as frequent hitters under both FBDD and HTS settings, although the problem was more pronounced in the fragment-based studies. As 2-ATs are present in known drugs, they cannot necessarily be deemed undesirable, but the combination of their promiscuity and difficulties associated with optimizing them into a lead compound makes them, in our opinion, poor scaffolds for fragment libraries. PMID:25559643

  5. [Recommendations for palivizumab use. Update 2015].

    PubMed

    Fernández Jonusas, Silvia; Albas Maubett, Deleys; Satragno, Daniela; Cattaino, Adriana; Martin Alonso, Margarita; Rubio, Cecilia; Nieto, Ricardo

    2016-02-01

    This recommendation updates the Argentinean Pediatrics' Neonatal Committee (CEFEN) ones published in 2007. The respiratory syncytial virus is the most frequent agent for lower respiratory infection. Tiny premature, bronchopulmonary dysplasia and significant hemodynamic congenital heart disease babies are the most vulnerable populations. Palivizumab is a humanized monoclonal antibody against respiratory syncytial virus used in the cold season. These recommendations are based on the scientific review of the literature published up to date. We reinforce the importance of general prevention measures like hand hygiene and family education among others. During the predominant season of respiratory syncytial virus in our country (April to September) a monthly dose of intramuscular 15 mg/kg of palivizumab is recommended. The safety and effectiveness has been proved as well as a reduction in the hospitalizations rates. In addition, epidemiological data of previous years are provided here. PMID:26914078

  6. Lennox-Gastaut syndrome. Management update.

    PubMed

    Al-Banji, Muradi H; Zahr, Doaa K; Jan, Mohammed M

    2015-07-01

    Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by mixed seizures, cognitive decline, and generalized slow (<3 Hz) spike wave discharges on electroencephalography. Atonic seizures result in dangerous drop attacks with risks of injury and impairment of the quality of life. The seizures are frequently resistant to multiple antiepileptic (AED) drugs. Newer AEDs, such as rufinamide, are now available. When multiple AED trials fail, non-pharmacological treatments such as the ketogenic diet, vagus nerve stimulation, and epilepsy surgery, should be considered. The aim of this review is to present an updated outline of LGS and the available treatments. Although the prognosis for complete seizure control remains poor, the addition of newer therapies provides an improved hope for some of these patients and their families. Further long term randomized controlled trials are required to compare different therapeutic interventions in terms of efficacy and tolerability. PMID:26166587

  7. Case studies on forecasting for innovative technologies: frequent revisions improve accuracy.

    PubMed

    Lerner, Jeffrey C; Robertson, Diane C; Goldstein, Sara M

    2015-02-01

    Health technology forecasting is designed to provide reliable predictions about costs, utilization, diffusion, and other market realities before the technologies enter routine clinical use. In this article we address three questions central to forecasting's usefulness: Are early forecasts sufficiently accurate to help providers acquire the most promising technology and payers to set effective coverage policies? What variables contribute to inaccurate forecasts? How can forecasters manage the variables to improve accuracy? We analyzed forecasts published between 2007 and 2010 by the ECRI Institute on four technologies: single-room proton beam radiation therapy for various cancers; digital breast tomosynthesis imaging technology for breast cancer screening; transcatheter aortic valve replacement for serious heart valve disease; and minimally invasive robot-assisted surgery for various cancers. We then examined revised ECRI forecasts published in 2013 (digital breast tomosynthesis) and 2014 (the other three topics) to identify inaccuracies in the earlier forecasts and explore why they occurred. We found that five of twenty early predictions were inaccurate when compared with the updated forecasts. The inaccuracies pertained to two technologies that had more time-sensitive variables to consider. The case studies suggest that frequent revision of forecasts could improve accuracy, especially for complex technologies whose eventual use is governed by multiple interactive factors. PMID:25646112

  8. Updates Technologies of Media Change

    ERIC Educational Resources Information Center

    Comer, Joshua

    2015-01-01

    Whether as status notifications in news feeds or interactive prompts in online video services, updates punctuate the background routines of media by bringing a variety of changes to the attention of users. In this dissertation I argue that updates rationalize media change by making previously obscure actions of users and movements of technologies…

  9. Perinatal neuroprotection update

    PubMed Central

    Jelin, Angie C.; Salmeen, Kirsten; Gano, Dawn; Burd, Irina; Thiet, Mari-Paule

    2016-01-01

    Antepartum, intrapartum, and neonatal events can result in a spectrum of long-term neurological sequelae, including cerebral palsy, cognitive delay, schizophrenia, and autism spectrum disorders [1]. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to decrease preterm delivery but also to improve neurological outcomes in infants delivered preterm. We recently published a comprehensive review addressing the impacts of magnesium sulfate, therapeutic hypothermia, delayed cord clamping, infections, and prevention of preterm delivery on the modification of neurological risk [2]. In this review, we will briefly provide updates to the aforementioned topics as well as an expansion on avoidance of toxin and infections, specifically the Zika virus. PMID:27606053

  10. Update on toxic myopathies.

    PubMed

    Mastaglia, F L; Needham, M

    2012-02-01

    The toxic myopathies are a clinically and pathologically diverse group of disorders that can be caused by a variety of therapeutic agents used in clinical practice, as well as various venoms and other biological toxins. The most important iatrogenic causes are the statin and fibrate cholesterol-lowering agents that can cause a severe necrotizing myopathy and acute rhabdomyolysis and myoglobinuria. The current update focuses on the mechanisms of statin myotoxicity and the importance of genetic predisposing factors for statin myopathy, as well as the recently described form of necrotizing autoimmune myopathy, which is associated with antibodies to the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme and is responsive to aggressive immunotherapy. Mitochondrial myopathies associated with antiretroviral agents and the pyrimidine nucleoside analogue clevudine, and recent reports of myopathies caused by ingestion of red yeast rice and toxic species of mushrooms are also discussed. PMID:21968786

  11. ILRS Website Update

    NASA Technical Reports Server (NTRS)

    Noll, Carey E.; Torrence, Mark H.; Pollack, Nathan H.; Tyahla, Lori J.

    2013-01-01

    The ILRS website, http://ilrs.gsfc.nasa.gov, is the central source of information for all aspects of the service. The website provides information on the organization and operation of the ILRS and descriptions of ILRS components data, and products. Furthermore, the website provides an entry point to the archive of these data products available through the data centers. Links are provided to extensive information on the ILRS network stations including performance assesments and data quality evaluations. Descriptions of suported satellite missions (current, future, and past) are provided to aid in station acquisition and data analysis. The website was reently redesigned. Content was reviewed during the update process, ensuring information is current and useful. This poster will provide specific examples of key sections, applicaitons, and webpages.

  12. Update on infection control.

    PubMed

    1999-12-01

    Infection control is a dynamic and ever-changing subject and all dental staff should be kept aware of the most up-to-date procedures required to prevent the transmission of infection and should understand why these procedures are necessary. Regular monitoring and updating of all procedures in the light of new scientific evidence is necessary and all new staff must be trained in infection control procedures prior to working in the surgery. A practitioner who is routinely following an appropriate infection control policy, including the use of techniques and products of proven efficacy (perhaps through accreditation), is better placed to refute allegations arising in the course of civil litigation, health and safety at work prosecution, complaints and disciplinary procedures, or investigations by the GDC. PMID:16892574

  13. Macrofouling control technology update

    SciTech Connect

    Tsou, J.L.; Armor, A.F.

    1996-12-31

    Macrofouling of condenser systems with debris, fish, clams, barnacles, mussels, algae, and other marine organisms can significantly affect power plant availability and performance. Typical difficulties include increased condenser back pressure due to reduced cooling-water flow, malfunctioning of on-line tube-cleaning equipment, and accelerated corrosion and erosion of tubing. In some severe cases, condenser back pressure increased to a point that the turbine had to be tripped. In 1981 EPRI initiated a research project to develop utility industry guidelines for reducing macrofouling problems. In 1987 EPRI published the Guidelines on Macrofouling Control Technology. Since then significant progress has been made by EPRI, utility members, equipment manufacturers, and others. The purpose of this paper is to update the macrofouling control technology. Control technology covered will include thermal treatment, mechanical removal devices, antifouling coatings, and chemical treatment.

  14. Perinatal neuroprotection update.

    PubMed

    Jelin, Angie C; Salmeen, Kirsten; Gano, Dawn; Burd, Irina; Thiet, Mari-Paule

    2016-01-01

    Antepartum, intrapartum, and neonatal events can result in a spectrum of long-term neurological sequelae, including cerebral palsy, cognitive delay, schizophrenia, and autism spectrum disorders [1]. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to decrease preterm delivery but also to improve neurological outcomes in infants delivered preterm. We recently published a comprehensive review addressing the impacts of magnesium sulfate, therapeutic hypothermia, delayed cord clamping, infections, and prevention of preterm delivery on the modification of neurological risk [2]. In this review, we will briefly provide updates to the aforementioned topics as well as an expansion on avoidance of toxin and infections, specifically the Zika virus. PMID:27606053

  15. LDEF environment modeling updates

    NASA Technical Reports Server (NTRS)

    Gordon, Tim; Rantanen, Ray; Whitaker, Ann F.

    1995-01-01

    An updated gas dynamics model for gas interactions around the LDEF is presented that includes improved scattering algorithms. The primary improvement is more accurate predictions of surface fluxes in the wake region. The code used is the Integrated Spacecraft Environments Model (ISEM). Additionally, initial results of a detailed ISEM prediction model of the Solar Array Passive LDEF Experiment (SAMPLE), A0171, is presented. This model includes details of the A0171 geometry and outgassing characteristics of the many surfaces on the experiment. The detailed model includes the multiple scattering that exists between the ambient atmosphere, LDEF outgassing, and atomic oxygen erosion products. Predictions are made for gas densities, surface fluxes and deposition at three different time periods of the LDEF mission.

  16. Neurocritical care update.

    PubMed

    Kuroda, Yasuhiro

    2016-01-01

    This update comprises six important topics under neurocritical care that require reevaluation. For post-cardiac arrest brain injury, the evaluation of the injury and its corresponding therapy, including temperature modulation, is required. Analgosedation for target temperature management is an essential strategy to prevent shivering and minimizes endogenous stress induced by catecholamine surges. For severe traumatic brain injury, the diverse effects of therapeutic hypothermia depend on the complicated pathophysiology of the condition. Continuous electroencephalogram monitoring is an essential tool for detecting nonconvulsive status epilepticus in the intensive care unit (ICU). Neurocritical care, including advanced hemodynamic monitoring, is a fundamental approach for delayed cerebral ischemia following subarachnoid hemorrhage. We must be mindful of the high percentage of ICU patients who may develop sepsis-associated brain dysfunction. PMID:27239312

  17. Updating the Read Codes

    PubMed Central

    Robinson, David; Comp, Dip; Schulz, Erich; Brown, Philip; Price, Colin

    1997-01-01

    Abstract The Read Codes are a hierarchically-arranged controlled clinical vocabulary introduced in the early 1980s and now consisting of three maintained versions of differing complexity. The code sets are dynamic, and are updated quarterly in response to requests from users including clinicians in both primary and secondary care, software suppliers, and advice from a network of specialist healthcare professionals. The codes' continual evolution of content, both across and within versions, highlights tensions between different users and uses of coded clinical data. Internal processes, external interactions and new structural features implemented by the NHS Centre for Coding and Classification (NHSCCC) for user interactive maintenance of the Read Codes are described, and over 2000 items of user feedback episodes received over a 15-month period are analysed. PMID:9391934

  18. International Space Station (ISS) Plasma Contactor Unit (PCU) Utilization Plan Assessment Update

    NASA Technical Reports Server (NTRS)

    Hernandez-Pellerano, Amri; Iannello, Christopher J.; Wollack, Edward J.; Wright, Kenneth H.; Garrett, Henry B.; Ging, Andrew T.; Katz, Ira; Keith, R. Lloyd; Minow, Joseph I.; Willis, Emily M.; Schneider, Todd A.; Whittlesey, Albert C.

    2014-01-01

    The NASA Engineering and Safety Center (NESC) received a request to support the Assessment of the International Space Station (ISS) Plasma Contactor Unit (PCU) Utilization Update. The NESC conducted an earlier assessment of the use of the PCU in 2009. This document contains the outcome of the assessment update.

  19. Practical Approaches for Mining Frequent Patterns in Molecular Datasets.

    PubMed

    Naulaerts, Stefan; Moens, Sandy; Engelen, Kristof; Berghe, Wim Vanden; Goethals, Bart; Laukens, Kris; Meysman, Pieter

    2016-01-01

    Pattern detection is an inherent task in the analysis and interpretation of complex and continuously accumulating biological data. Numerous itemset mining algorithms have been developed in the last decade to efficiently detect specific pattern classes in data. Although many of these have proven their value for addressing bioinformatics problems, several factors still slow down promising algorithms from gaining popularity in the life science community. Many of these issues stem from the low user-friendliness of these tools and the complexity of their output, which is often large, static, and consequently hard to interpret. Here, we apply three software implementations on common bioinformatics problems and illustrate some of the advantages and disadvantages of each, as well as inherent pitfalls of biological data mining. Frequent itemset mining exists in many different flavors, and users should decide their software choice based on their research question, programming proficiency, and added value of extra features. PMID:27168722

  20. Personality Profiles and Frequent Heavy Drinking in Young Adulthood

    PubMed Central

    Bray, Bethany C.; Zhang, Minqiang; Lanza, Stephanie T.

    2015-01-01

    Few studies examining the link between personality and alcohol use have adopted a comprehensive modeling framework to take into account individuals’ profiles across multiple personality traits. In this study, latent profile analysis (LPA) was applied to a national sample of young adults in the United States to identify subgroups defined by their profiles of mean scores on the Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness personality factors. Personality profiles were then used to predict heavy drinking. Five profiles were identified: Reserved, Rigid, Confident, Ordinary, and Resilient. Compared to individuals in the Ordinary profile, those with Reserved and Resilient profiles were at increased risk of frequent heavy drinking. These findings suggest which comprehensive personality profiles may place individuals at risk for problematic alcohol-related outcomes. PMID:25892836

  1. Practical Approaches for Mining Frequent Patterns in Molecular Datasets

    PubMed Central

    Naulaerts, Stefan; Moens, Sandy; Engelen, Kristof; Berghe, Wim Vanden; Goethals, Bart; Laukens, Kris; Meysman, Pieter

    2016-01-01

    Pattern detection is an inherent task in the analysis and interpretation of complex and continuously accumulating biological data. Numerous itemset mining algorithms have been developed in the last decade to efficiently detect specific pattern classes in data. Although many of these have proven their value for addressing bioinformatics problems, several factors still slow down promising algorithms from gaining popularity in the life science community. Many of these issues stem from the low user-friendliness of these tools and the complexity of their output, which is often large, static, and consequently hard to interpret. Here, we apply three software implementations on common bioinformatics problems and illustrate some of the advantages and disadvantages of each, as well as inherent pitfalls of biological data mining. Frequent itemset mining exists in many different flavors, and users should decide their software choice based on their research question, programming proficiency, and added value of extra features. PMID:27168722

  2. Frequent mutations in chromatin-remodeling genes in pulmonary carcinoids

    PubMed Central

    Lu, Xin; Sun, Ruping; Ozretić, Luka; Seidal, Danila; Zander, Thomas; Leenders, Frauke; George, Julie; Müller, Christian; Dahmen, Ilona; Pinther, Berit; Bosco, Graziella; Konrad, Kathryn; Altmüller, Janine; Nürnberg, Peter; Achter, Viktor; Lang, Ulrich; Schneider, Peter M; Bogus, Magdalena; Soltermann, Alex; Brustugun, Odd Terje; Helland, Åslaug; Solberg, Steinar; Lund-Iversen, Marius; Ansén, Sascha; Stoelben, Erich; Wright, Gavin M.; Russell, Prudence; Wainer, Zoe; Solomon, Benjamin; Field, John K; Hyde, Russell; Davies, Michael PA.; Heukamp, Lukas C; Petersen, Iver; Perner, Sven; Lovly, Christine; Cappuzzo, Federico; Travis, William D; Wolf, Jürgen; Vingron, Martin; Brambilla, Elisabeth; Haas, Stefan A.; Buettner, Reinhard; Thomas, Roman K

    2014-01-01

    Pulmonary carcinoids are rare neuroendocrine tumors of the lung. The molecular alterations underlying the pathogenesis of these tumors have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and observe frequent mutations in chromatin-remodeling genes. Covalent histone modifiers and subunits of the SWI/SNF complex are mutated in 40% and 22.2% of the cases respectively, with MEN1, PSIP1 and ARID1A being recurrently affected. In contrast to small-cell lung cancer and large-cell neuroendocrine tumors, TP53 and RB1 mutations are rare events, suggesting that pulmonary carcinoids are not early progenitor lesions of the highly aggressive lung neuroendocrine tumors but arise through independent cellular mechanisms. These data also suggest that inactivation of chromatin remodeling genes is sufficient to drive transformation in pulmonary carcinoids. PMID:24670920

  3. Frequent Replenishment Sustains the Beneficial Microbiome of Drosophila melanogaster

    PubMed Central

    Blum, Jessamina E.; Fischer, Caleb N.; Miles, Jessica; Handelsman, Jo

    2013-01-01

    ABSTRACT We report that establishment and maintenance of the Drosophila melanogaster microbiome depend on ingestion of bacteria. Frequent transfer of flies to sterile food prevented establishment of the microbiome in newly emerged flies and reduced the predominant members, Acetobacter and Lactobacillus spp., by 10- to 1,000-fold in older flies. Flies with a normal microbiome were less susceptible than germfree flies to infection by Serratia marcescens and Pseudomonas aeruginosa. Augmentation of the normal microbiome with higher populations of Lactobacillus plantarum, a Drosophila commensal and probiotic used in humans, further protected the fly from infection. Replenishment represents an unexplored strategy by which animals can sustain a gut microbial community. Moreover, the population behavior and health benefits of L. plantarum resemble features of certain probiotic bacteria administered to humans. As such, L. plantarum in the fly gut may serve as a simple model for dissecting the population dynamics and mode of action of probiotics in animal hosts. PMID:24194543

  4. Consequences of Frequent Hemodialysis: Comparison to Conventional Hemodialysis and Transplantation

    PubMed Central

    Stokes, John B.

    2011-01-01

    The average life expectancy of a person on hemodialysis is less than 3 years and hasn't changed in 20 years. The Hemodialysis (HEMO) trial, a randomized trial to determine whether increasing urea removal to the maximum practical degree through a 3-times-a-week schedule, showed no difference in mortality in the treatment and control groups. Investigators speculated that the increment in functional waste removal in the HEMO study was too small to produce improvements in mortality. To test this hypothesis, the NIDDK funded the Frequent Hemodialysis Network, a consortium of centers testing whether patients randomized to intensive dialysis would demonstrate improved (reduced) left ventricular LV mass and quality of life. The trial has two arms: the daily (in-center) and the home (nocturnal) arms. Each arm has patients randomized to conventional dialysis or 6 days (or nights) of dialysis. The results of the HEMO trial will be reported in the fall of 2010. PMID:21686215

  5. Frequent detection of stomach contents in accidental drowning.

    PubMed

    Kibayashi, Kazuhiko; Shimada, Ryo; Nakao, Ken-Ichiro

    2011-07-01

    We analysed forensic autopsies of 536 consecutive adults to determine the relationship between the presence of stomach contents and the manner of death. Stomach contents were identified in 27 (79.4%) of 34 accidental drownings and in 22 (43.1%) of 51 suicidal drownings (P < 0.01). Accidental drowning was the manner of death most frequently associated with the presence of stomach contents, and stomach contents were found significantly more often in this type of death than in suicidal drowning. These findings indicate that food intake is a factor possibly related to accidental drowning and suggest that fasting may be required before swimming or taking a bath to prevent accidental drowning. PMID:21905572

  6. Imagery rehearsal therapy for frequent nightmares in children.

    PubMed

    St-Onge, Mélanie; Mercier, Pierre; De Koninck, Joseph

    2009-01-01

    This study examined the applicability of imagery rehearsal therapy (IRT) to children with frequent nightmares. Eleven boys and 9 girls aged 9 to 11, with moderate to severe primary nightmares (1 or more per week for 6 months) and without posttraumatic stress disorder, were randomly divided into an imagery rehearsal treatment group (n = 9) or a waiting-list (n = 11) group. ANCOVA with repeated measures revealed that, following a baseline period, IRT reduced the frequency of nightmares (p < .04; eta(2) = 0.22) in the treated group compared to the waiting-list group. This reduction was maintained over a 9-month follow-up. The effects of IRT on post-nightmare state distress could not be assessed due to low nightmare incidences. However, retrospective trait nightmare distress was not significantly reduced. Future research is needed to validate this simple approach for nightmare reduction and to evaluate its potential for the reduction of the associated nightmare distress. PMID:19330581

  7. Homeodomain proteins: an update.

    PubMed

    Bürglin, Thomas R; Affolter, Markus

    2016-06-01

    Here, we provide an update of our review on homeobox genes that we wrote together with Walter Gehring in 1994. Since then, comprehensive surveys of homeobox genes have become possible due to genome sequencing projects. Using the 103 Drosophila homeobox genes as example, we present an updated classification. In animals, there are 16 major classes, ANTP, PRD, PRD-LIKE, POU, HNF, CUT (with four subclasses: ONECUT, CUX, SATB, and CMP), LIM, ZF, CERS, PROS, SIX/SO, plus the TALE superclass with the classes IRO, MKX, TGIF, PBC, and MEIS. In plants, there are 11 major classes, i.e., HD-ZIP (with four subclasses: I to IV), WOX, NDX, PHD, PLINC, LD, DDT, SAWADEE, PINTOX, and the two TALE classes KNOX and BEL. Most of these classes encode additional domains apart from the homeodomain. Numerous insights have been obtained in the last two decades into how homeodomain proteins bind to DNA and increase their specificity by interacting with other proteins to regulate cell- and tissue-specific gene expression. Not only protein-DNA base pair contacts are important for proper target selection; recent experiments also reveal that the shape of the DNA plays a role in specificity. Using selected examples, we highlight different mechanisms of homeodomain protein-DNA interaction. The PRD class of homeobox genes was of special interest to Walter Gehring in the last two decades. The PRD class comprises six families in Bilateria, and tinkers with four different motifs, i.e., the PAIRED domain, the Groucho-interacting motif EH1 (aka Octapeptide or TN), the homeodomain, and the OAR motif. Homologs of the co-repressor protein Groucho are also present in plants (TOPLESS), where they have been shown to interact with small amphipathic motives (EAR), and in yeast (TUP1), where we find an EH1-like motif in MATα2. PMID:26464018

  8. Gearbox Reliability Collaborative Update: A Brief (Presentation)

    SciTech Connect

    Sheng, S.; Keller, J.; McDade, M.

    2012-01-01

    This presentation is an update on the Gearbox Reliability Collaborative (GRC) for the AWEA Wind Project Operations, Maintenance & Reliability Seminar. GRC accomplishments are: (1) Failure database software deployed - partners see business value for themselves and customers; (2) Designed, built, instrumented, and tested two gearboxes - (a) Generated unprecedented public domain test data from both field testing and dynamometer testing, (b) Different responses from 'identical' gearboxes, (c) Demonstrated importance of non-torque loading and modeling approach; and (3) Active collaborative, with wide industry support, leveraging DOE funding - Modeling round robin and Condition Monitoring round robin.

  9. An update of input instructions to TEMOD

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The theory and operation of a FORTRAN 4 computer code, designated as TEMOD, used to calcuate tubular thermoelectric generator performance is described in WANL-TME-1906. The original version of TEMOD was developed in 1969. A description is given of additions to the mathematical model and an update of the input instructions to the code. Although the basic mathematical model described in WANL-TME-1906 has remained unchanged, a substantial number of input/output options were added to allow completion of module performance parametrics as required in support of the compact thermoelectric converter system technology program.

  10. [Microscopic colitis: update 2014].

    PubMed

    Burgmann, Konstantin; Fraga, Montserrat; Schoepfer, Alain M; Yun, Pu

    2014-09-01

    Microscopic colitis, which includes lymphocytic colitis and collagenous colitis, represents a frequent cause of chronic watery diarrhea especially in the elderly population. Several medications, such as nonsteroidal antiinflammatory drugs, proton pump inhibitors or antidepressants, as well as cigarette smoking have been recognized as risk factors for microscopic colitis. The diagnosis of microscopic colitis is based on a macroscopically normal ileo-colonoscopy and several biopsies from the entire colon, which demonstrate the pathognomonic histopathologic findings. Therapy is mainly based on the use of budesonide. Other medications, such as mesalazine, cholestyramine and bismuth, have been evaluated as well but the evidence is less solid. PMID:25276996

  11. French Immersion in Canada: Frequently Asked Questions (FAQs).

    ERIC Educational Resources Information Center

    Obadia, Andre A.

    This brochure, intended for the parents of current and prospective French immersion students, answers commonly-asked questions about immersion education, including who should participate, how good the child's French will be, whether immersion students are likely to lose ground in English or academic subjects, how parents can provide support at…

  12. Care Practice #3: Continuous Labor Support

    PubMed Central

    Green, Jeanne; Amis, Debby; Hotelling, Barbara A.

    2007-01-01

    This updated edition of Care Practice Paper #3 presents the evidence for the benefits of continuous support in labor. The role of the doula is explained. Women are encouraged to plan for continuous support during labor and to consider including a woman experienced with childbirth among their labor support team. PMID:18566654

  13. ISS Update: SpaceX Dragon Launch Update

    NASA Video Gallery

    NASA Public Affairs Office commentator Pat Ryan talks with Mike Horkachuck, NASA Project Executive for SpaceX, for an update on the SpaceX Dragon's next launch attempt scheduled for Tuesday at 3:44...

  14. A Case Study of Private Schools in Kibera: An Update

    ERIC Educational Resources Information Center

    Dixon, Pauline; Tooley, James

    2012-01-01

    This article provides an update on our earlier paper on the introduction by the Kenyan government in 2003 of free primary education (FPE), and its impact on low-fee private schools. First, published papers that have used our contribution as a springboard for discussion are critically reviewed. The argument and supporting evidence that the poor are…

  15. 77 FR 19077 - Adoption of Updated EDGAR Filer Manual

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... COMMISSION 17 CFR Part 232 Adoption of Updated EDGAR Filer Manual AGENCY: Securities and Exchange Commission... revisions to the Electronic Data Gathering, Analysis, and Retrieval System (EDGAR) Filer Manual to reflect... system is scheduled to be upgraded to support this functionality on March 26, 2012. The filer manual...

  16. Neural dissociations between meaningful and mere inconsistency in impression updating.

    PubMed

    Mende-Siedlecki, Peter; Todorov, Alexander

    2016-09-01

    Recent neuroimaging work has identified a network of regions that work in concert to update impressions of other people, particularly in response to inconsistent behavior. However, the specific functional contributions of these regions to the updating process remain unclear. Using fMRI, we tested whether increases in activity triggered by inconsistent behavior reflect changes in the stored representations of other people in response to behavioral inconsistency, or merely a response to the inconsistency itself. Participants encountered a series of individuals whose behavior either changed in an attributionally meaningful fashion or was merely inconsistent with the immediately preceding behavior. We observed that left ventrolateral prefrontal cortex (vlPFC) and left inferior frontal gyrus (IFG) were preferentially recruited in response to unexpected, immoral behavior, whereas a separate set of regions (including dorsal anterior cingulate cortex, posterior cingulate cortex and temporoparietal junction/inferior parietal lobule) was preferentially recruited in response to more mundane inconsistencies in behavior. These results shed light on the distributed systems supporting impression updating. Specifically, while many regions supporting updating may primarily respond to moment-to-moment changes in behavior, a subset of regions (e.g. vlPFC and IFG) may contribute to updating person representations in response to trait-relevant changes in behavior. PMID:27217118

  17. Posterior reversible encephalopathy syndrome (PRES) and hypomagnesemia: A frequent association?

    PubMed

    Chardain, A; Mesnage, V; Alamowitch, S; Bourdain, F; Crozier, S; Lenglet, T; Psimaras, D; Demeret, S; Graveleau, P; Hoang-Xuan, K; Levy, R

    2016-01-01

    Posterior reversible encephalopathy syndrome (PRES) is a serious neurological condition encountered in various medical fields. Pathophysiological factor(s) common to PRES cases of apparently unrelated etiologies are yet to be found. Based on the hypothesis that hypomagnesemia might participate in the cascade leading to PRES, our study sought to verify whether hypomagnesemia is frequently associated with PRES regardless of etiology. From a retrospective study of a cohort of 57 patients presenting with PRES of different etiologies, presented here are the findings of 19 patients with available serum magnesium levels (SMLs) during PRES. In the acute phase of PRES, hypomagnesemia was present in all 19 patients in spite of differences in etiology (including immunosuppressive drugs, hypertensive encephalopathy, eclampsia, systemic lupus erythematosus, iatrogenic etiology and unknown). SMLs were within normal ranges prior to PRES and below normal ranges during the first 48h of PRES, with a significant decrease in SMLs during the acute phase. In this retrospective study, constant hypomagnesemia was observed during the acute phase of PRES regardless of its etiology. These results now require larger studies to assess the particular importance of acute hypomagnesemia in PRES and especially the possible need to treat PRES with magnesium sulfate. PMID:27371132

  18. Frequent Occurrence of Mixed Enterocytozoon bieneusi Infections in Humans

    PubMed Central

    Widmer, Giovanni; Dilo, Julia; Tumwine, James K.; Tzipori, Saul

    2013-01-01

    Enterocytozoon bieneusi (phylum Microsporidia) is a human pathogen with a broad host range. Following the sequencing of 3.8 Mb of the estimated 6-Mb E. bieneusi genome, simple sequence repeats (micro- and minisatellites) were identified. Sequencing of four such repeats from various human and animal E. bieneusi isolates identified extensive sequence polymorphism and enabled the development of a multilocus genotyping method to study the epidemiology of this pathogen. We genotyped E. bieneusi DNA extracted from 197 fecal samples originating from children with diarrhea who were residing in Kampala, Uganda. Three newly identified microsatellite markers and the internal transcribed spacer were PCR amplified, and multiple cloned amplicons for each marker were sequenced from each individual. Most microsatellite sequences were unique to the Ugandan population. Significantly, polymorphism not only was present among isolates but was also found within isolates. This observation suggests that infections with heterogeneous E. bieneusi populations are common in this region. However, the data do not exclude that some of the polymorphism originates from divergent paralogs within the genome. The frequent occurrence of multiple sequences within an isolate precluded the identification of multilocus genotypes. This observation raises the possibility that in a region in which the prevalence of E. bieneusi is high, sequencing of uncloned PCR products may not be adequate for multilocus genotyping. PMID:23811516

  19. Tetrasomic Recombination Is Surprisingly Frequent in Allotetraploid Arachis

    PubMed Central

    Leal-Bertioli, Soraya; Shirasawa, Kenta; Abernathy, Brian; Moretzsohn, Marcio; Chavarro, Carolina; Clevenger, Josh; Ozias-Akins, Peggy; Jackson, Scott; Bertioli, David

    2015-01-01

    Arachis hypogaea L. (cultivated peanut) is an allotetraploid (2n = 4x = 40) with an AABB genome type. Based on cytogenetic studies it has been assumed that peanut and wild-derived induced AABB allotetraploids have classic allotetraploid genetic behavior with diploid-like disomic recombination only between homologous chromosomes, at the exclusion of recombination between homeologous chromosomes. Using this assumption, numerous linkage map and quantitative trait loci studies have been carried out. Here, with a systematic analysis of genotyping and gene expression data, we show that this assumption is not entirely valid. In fact, autotetraploid-like tetrasomic recombination is surprisingly frequent in recombinant inbred lines generated from a cross of cultivated peanut and an induced allotetraploid derived from peanut’s most probable ancestral species. We suggest that a better, more predictive genetic model for peanut is that of a “segmental allotetraploid” with partly disomic, partly tetrasomic genetic behavior. This intermediate genetic behavior has probably had a previously overseen, but significant, impact on the genome and genetics of cultivated peanut. PMID:25701284

  20. Functional epigenetic approach identifies frequently methylated genes in Ewing sarcoma.

    PubMed

    Alholle, Abdullah; Brini, Anna T; Gharanei, Seley; Vaiyapuri, Sumathi; Arrigoni, Elena; Dallol, Ashraf; Gentle, Dean; Kishida, Takeshi; Hiruma, Toru; Avigad, Smadar; Grimer, Robert; Maher, Eamonn R; Latif, Farida

    2013-11-01

    Using a candidate gene approach we recently identified frequent methylation of the RASSF2 gene associated with poor overall survival in Ewing sarcoma (ES). To identify effective biomarkers in ES on a genome-wide scale, we used a functionally proven epigenetic approach, in which gene expression was induced in ES cell lines by treatment with a demethylating agent followed by hybridization onto high density gene expression microarrays. After following a strict selection criterion, 34 genes were selected for expression and methylation analysis in ES cell lines and primary ES. Eight genes (CTHRC1, DNAJA4, ECHDC2, NEFH, NPTX2, PHF11, RARRES2, TSGA14) showed methylation frequencies of>20% in ES tumors (range 24-71%), these genes were expressed in human bone marrow derived mesenchymal stem cells (hBMSC) and hypermethylation was associated with transcriptional silencing. Methylation of NPTX2 or PHF11 was associated with poorer prognosis in ES. In addition, six of the above genes also showed methylation frequency of>20% (range 36-50%) in osteosarcomas. Identification of these genes may provide insights into bone cancer tumorigenesis and development of epigenetic biomarkers for prognosis and detection of these rare tumor types. PMID:24005033

  1. FREQUENT SPIN REORIENTATION OF GALAXIES DUE TO LOCAL INTERACTIONS

    SciTech Connect

    Cen, Renyue

    2014-04-10

    We study the evolution of angular momenta of M {sub *} = 10{sup 10}-10{sup 12} M {sub ☉} galaxies utilizing large-scale ultra-high resolution cosmological hydrodynamic simulations and find that the spin of the stellar component changes direction frequently because of interactions with nearby systems, such as major mergers, minor mergers, significant gas inflows, and torques. The rate and nature of change of spin direction cannot be accounted for by large-scale tidal torques, because the rates of the latter fall short by orders of magnitude and because the apparent random swings of the spin direction are inconsistent with the alignment by linear density field. The implications for galaxy formation as well as the intrinsic alignment of galaxies are profound. Assuming the large-scale tidal field is the sole alignment agent, a new picture emerging is that intrinsic alignment of galaxies would be a balance between slow large-scale coherent torquing and fast spin reorientation by local interactions. What is still open is whether other processes, such as feeding galaxies with gas and stars along filaments or sheets, introduce coherence for spin directions of galaxies along the respective structures.

  2. Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms

    PubMed Central

    Nishikawa, G; Sekine, S; Ogawa, R; Matsubara, A; Mori, T; Taniguchi, H; Kushima, R; Hiraoka, N; Tsuta, K; Tsuda, H; Kanai, Y

    2013-01-01

    Background: The molecular basis for the development of appendiceal mucinous tumours, which can be a cause of pseudomyxoma peritonei, remains largely unknown. Methods: Thirty-five appendiceal mucinous neoplasms were analysed for GNAS and KRAS mutations. A functional analysis of mutant GNAS was performed using a colorectal cancer cell line. Results: A mutational analysis identified activating GNAS mutations in 16 of 32 low-grade appendiceal mucinous neoplasms (LAMNs) but in none of three mucinous adenocarcinomas (MACs). KRAS mutations were found in 30 LAMNs and in all MACs. We additionally analysed a total of 186 extra-appendiceal mucinous tumours and found that GNAS mutations were highly prevalent in intraductal papillary mucinous tumours of the pancreas (88%) but were rare or absent in mucinous tumours of the colorectum, ovary, lung and breast (0–9%). The prevalence of KRAS mutations was quite variable among the tumours. The introduction of the mutant GNAS into a colorectal cancer cell line markedly induced MUC2 and MUC5AC expression, but did not promote cell growth either in vitro or in vivo. Conclusion: Activating GNAS mutations are a frequent and characteristic genetic abnormality of LAMN. Mutant GNAS might play a direct role in the prominent mucin production that is a hallmark of LAMN. PMID:23403822

  3. Evidence and Implications of Frequent Fires in Ancient Shrub Tundra

    SciTech Connect

    Higuera, P E; Brubaker, L B; Anderson, P M; Brown, T A; Kennedy, A T; Hu, F S

    2008-03-06

    Understanding feedbacks between terrestrial and atmospheric systems is vital for predicting the consequences of global change, particularly in the rapidly changing Arctic. Fire is a key process in this context, but the consequences of altered fire regimes in tundra ecosystems are rarely considered, largely because tundra fires occur infrequently on the modern landscape. We present paleoecological data that indicate frequent tundra fires in northcentral Alaska between 14,000 and 10,000 years ago. Charcoal and pollen from lake sediments reveal that ancient birchdominated shrub tundra burned as often as modern boreal forests in the region, every 144 years on average (+/- 90 s.d.; n = 44). Although paleoclimate interpretations and data from modern tundra fires suggest that increased burning was aided by low effective moisture, vegetation cover clearly played a critical role in facilitating the paleo-fires by creating an abundance of fine fuels. These records suggest that greater fire activity will likely accompany temperature-related increases in shrub-dominated tundra predicted for the 21st century and beyond. Increased tundra burning will have broad impacts on physical and biological systems as well as land-atmosphere interactions in the Arctic, including the potential to release stored organic carbon to the atmosphere.

  4. Myocardial ischaemia in patients with frequent angina pectoris.

    PubMed Central

    Selwyn, A P; Fox, K; Eves, M; Oakley, D; Dargie, H; Shillingford, J

    1978-01-01

    One hundred patients with angina pectoris underwent 16-point electrocardiographic (ECG) mapping of the left hemithorax during a standardised exercise test. Forty-five patients had maximum ST-segment depression at position V5, while 35 had no ECG signs of ischaemia at this position. In 20 V5 was on the edge of the precordial area, which showed less severe ST-depression than the central positions. An Oxford ECG recorder and highspeed analyser were modified and used in 50 of the patients with daily angina for recording ST-segment changes over 24 hours. Serial 24-hour ambulatory recordings from the edge of the precordial area of ischaemia identified during exercise detected a mean of only 14 +/- SD 3% of the episodes of ST-segment changes recorded from the centre of the same area. Only 16 +/- 2% of the episodes detected by ECG were accompanied by chest pain. More episodes occurred between 4 am and 6 am than at any other time during the night. This study shows the importance of recording ECG evidence of ischaemia from the precordial position showing maximum changes during exercise. ECG evidence of ischaemia occurs more frequently than anginal pain. These objective measurements add important information to the frequency of chest pain reported by patients with ischaemic heart disease. Images FIG 3 PMID:728737

  5. Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

    PubMed Central

    Patch, Ann-Marie; Bailey, Peter; Newell, Felicity; Holmes, Oliver; Fink, J. Lynn; Quinn, Michael C.J.; Tang, Yue Hang; Lampe, Guy; Quek, Kelly; Loffler, Kelly A.; Manning, Suzanne; Idrisoglu, Senel; Miller, David; Xu, Qinying; Waddell, Nick; Wilson, Peter J.; Bruxner, Timothy J.C.; Christ, Angelika N.; Harliwong, Ivon; Nourse, Craig; Nourbakhsh, Ehsan; Anderson, Matthew; Kazakoff, Stephen; Leonard, Conrad; Wood, Scott; Simpson, Peter T.; Reid, Lynne E.; Krause, Lutz; Hussey, Damian J.; Watson, David I.; Lord, Reginald V.; Nancarrow, Derek; Phillips, Wayne A.; Gotley, David; Smithers, B. Mark; Whiteman, David C.; Hayward, Nicholas K.; Campbell, Peter J.; Pearson, John V.; Grimmond, Sean M.; Barbour, Andrew P.

    2015-01-01

    Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic driving events have been underrepresented. Here we use a combination of whole-genome sequencing (WGS) and single-nucleotide polymorphism-array profiling to show that genomic catastrophes are frequent in EAC, with almost a third (32%, n = 40/123) undergoing chromothriptic events. WGS of 22 EAC cases show that catastrophes may lead to oncogene amplification through chromothripsis-derived double-minute chromosome formation (MYC and MDM2) or breakage-fusion-bridge (KRAS, MDM2 and RFC3). Telomere shortening is more prominent in EACs bearing localized complex rearrangements. Mutational signature analysis also confirms that extreme genomic instability in EAC can be driven by somatic BRCA2 mutations. These findings suggest that genomic catastrophes have a significant role in the malignant transformation of EAC. PMID:25351503

  6. The most frequent short sequences in non-coding DNA.

    PubMed

    Subirana, Juan A; Messeguer, Xavier

    2010-03-01

    The purpose of this work is to determine the most frequent short sequences in non-coding DNA. They may play a role in maintaining the structure and function of eukaryotic chromosomes. We present a simple method for the detection and analysis of such sequences in several genomes, including Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster and Homo sapiens. We also study two chromosomes of man and mouse with a length similar to the whole genomes of the other species. We provide a list of the most common sequences of 9-14 bases in each genome. As expected, they are present in human Alu sequences. Our programs may also give a graph and a list of their position in the genome. Detection of clusters is also possible. In most cases, these sequences contain few alternating regions. Their intrinsic structure and their influence on nucleosome formation are not known. In particular, we have found new features of short sequences in C. elegans, which are distributed in heterogeneous clusters. They appear as punctuation marks in the chromosomes. Such clusters are not found in either A. thaliana or D. melanogaster. We discuss the possibility that they play a role in centromere function and homolog recognition in meiosis. PMID:19966278

  7. Smartphone gaming and frequent use pattern associated with smartphone addiction.

    PubMed

    Liu, Chun-Hao; Lin, Sheng-Hsuan; Pan, Yuan-Chien; Lin, Yu-Hsuan

    2016-07-01

    The aim of this study was to investigate the risk factors of smartphone addiction in high school students.A total of 880 adolescents were recruited from a vocational high school in Taiwan in January 2014 to complete a set of questionnaires, including the 10-item Smartphone Addiction Inventory, Chen Internet Addiction Scale, and a survey of content and patterns of personal smartphone use. Of those recruited, 689 students (646 male) aged 14 to 21 and who owned a smartphone completed the questionnaire. Multiple linear regression models were used to determine the variables associated with smartphone addiction.Smartphone gaming and frequent smartphone use were associated with smartphone addiction. Furthermore, both the smartphone gaming-predominant and gaming with multiple-applications groups showed a similar association with smartphone addiction. Gender, duration of owning a smartphone, and substance use were not associated with smartphone addiction.Our findings suggest that smartphone use patterns should be part of specific measures to prevent and intervene in cases of excessive smartphone use. PMID:27428191

  8. Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

    PubMed

    Nones, Katia; Waddell, Nicola; Wayte, Nicci; Patch, Ann-Marie; Bailey, Peter; Newell, Felicity; Holmes, Oliver; Fink, J Lynn; Quinn, Michael C J; Tang, Yue Hang; Lampe, Guy; Quek, Kelly; Loffler, Kelly A; Manning, Suzanne; Idrisoglu, Senel; Miller, David; Xu, Qinying; Waddell, Nick; Wilson, Peter J; Bruxner, Timothy J C; Christ, Angelika N; Harliwong, Ivon; Nourse, Craig; Nourbakhsh, Ehsan; Anderson, Matthew; Kazakoff, Stephen; Leonard, Conrad; Wood, Scott; Simpson, Peter T; Reid, Lynne E; Krause, Lutz; Hussey, Damian J; Watson, David I; Lord, Reginald V; Nancarrow, Derek; Phillips, Wayne A; Gotley, David; Smithers, B Mark; Whiteman, David C; Hayward, Nicholas K; Campbell, Peter J; Pearson, John V; Grimmond, Sean M; Barbour, Andrew P

    2014-01-01

    Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic driving events have been underrepresented. Here we use a combination of whole-genome sequencing (WGS) and single-nucleotide polymorphism-array profiling to show that genomic catastrophes are frequent in EAC, with almost a third (32%, n=40/123) undergoing chromothriptic events. WGS of 22 EAC cases show that catastrophes may lead to oncogene amplification through chromothripsis-derived double-minute chromosome formation (MYC and MDM2) or breakage-fusion-bridge (KRAS, MDM2 and RFC3). Telomere shortening is more prominent in EACs bearing localized complex rearrangements. Mutational signature analysis also confirms that extreme genomic instability in EAC can be driven by somatic BRCA2 mutations. These findings suggest that genomic catastrophes have a significant role in the malignant transformation of EAC. PMID:25351503

  9. Frequently asked questions about family medicine in India.

    PubMed

    Kumar, Raman

    2016-01-01

    Family medicine (FM) is an independent and distinct medical specialty in the developed countries such as USA, UK, Australia, and Canada since 1960s. FM teaching is imparted at undergraduate and postgraduate levels in countries such as Nepal, Pakistan, and Sri Lanka. Family practice is the practicing vocation of the majority doctors in India. The practitioners of FM include general practitioners, family physicians, FM specialists, and medical officers in the public sector. Medical students are largely unaware about FM career as this concept is not introduced at MBBS level. Faculty and senior doctors from other disciplines are also not able to answer the queries related to FM as they themselves also have gone through the same education system for last three decades, largely unexposed to the concept of academic family medicine. This article is a compilation of frequently asked questions, and their appropriate responses, presented here to dispel myths and misinformation about FM specialty. The answers are deliberated upon by Dr. Raman Kumar the founder president of the Academy of Family Physicians of India and the chief editor of the Journal of Family Medicine and Primary Care. This article was originally published as an interview in Docplexus, a popular online network and website for medical doctors in November 2015. PMID:27453835

  10. Smartphone gaming and frequent use pattern associated with smartphone addiction

    PubMed Central

    Liu, Chun-Hao; Lin, Sheng-Hsuan; Pan, Yuan-Chien; Lin, Yu-Hsuan

    2016-01-01

    Abstract The aim of this study was to investigate the risk factors of smartphone addiction in high school students. A total of 880 adolescents were recruited from a vocational high school in Taiwan in January 2014 to complete a set of questionnaires, including the 10-item Smartphone Addiction Inventory, Chen Internet Addiction Scale, and a survey of content and patterns of personal smartphone use. Of those recruited, 689 students (646 male) aged 14 to 21 and who owned a smartphone completed the questionnaire. Multiple linear regression models were used to determine the variables associated with smartphone addiction. Smartphone gaming and frequent smartphone use were associated with smartphone addiction. Furthermore, both the smartphone gaming-predominant and gaming with multiple-applications groups showed a similar association with smartphone addiction. Gender, duration of owning a smartphone, and substance use were not associated with smartphone addiction. Our findings suggest that smartphone use patterns should be part of specific measures to prevent and intervene in cases of excessive smartphone use. PMID:27428191

  11. Frequently asked questions about family medicine in India

    PubMed Central

    Kumar, Raman

    2016-01-01

    Family medicine (FM) is an independent and distinct medical specialty in the developed countries such as USA, UK, Australia, and Canada since 1960s. FM teaching is imparted at undergraduate and postgraduate levels in countries such as Nepal, Pakistan, and Sri Lanka. Family practice is the practicing vocation of the majority doctors in India. The practitioners of FM include general practitioners, family physicians, FM specialists, and medical officers in the public sector. Medical students are largely unaware about FM career as this concept is not introduced at MBBS level. Faculty and senior doctors from other disciplines are also not able to answer the queries related to FM as they themselves also have gone through the same education system for last three decades, largely unexposed to the concept of academic family medicine. This article is a compilation of frequently asked questions, and their appropriate responses, presented here to dispel myths and misinformation about FM specialty. The answers are deliberated upon by Dr. Raman Kumar the founder president of the Academy of Family Physicians of India and the chief editor of the Journal of Family Medicine and Primary Care. This article was originally published as an interview in Docplexus, a popular online network and website for medical doctors in November 2015. PMID:27453835

  12. Chest Pain: The Need to Consider Less Frequent Diagnosis

    PubMed Central

    Morais, Anabela; Carvalho, Sofia; Cunha, Joana; Lima, Ana R.; Moreira, J. Ilídio; Faria, Trigo

    2016-01-01

    Chest pain is one of the most frequent patient's complaints. The commonest underlying causes are well known, but, sometimes, in some clinical scenarios, it is necessary to consider other diagnoses. We report a case of a 68-year-old Caucasian male, chronically hypertensive, who complained of recurrent episodes of chest pain and fever with elevated acute phase reactants. The first investigation was negative for some of the most likely diagnosis and he quickly improved with anti-inflammatory drugs. Over a few months, his symptoms continued to recur periodically, his hypertension was aggravated, and he developed headaches and lower limbs claudication. After a temporal artery biopsy that was negative for vasculitis, he underwent a positron emission tomography suggestive of Takayasu Arteritis. Takayasu Arteritis is a rare chronic granulomatous vasculitis of the aorta and its first-order branches affecting mostly females up to 50 years old. Chest pain is experienced by >40% of the patients and results from the inflammation of the aorta, pulmonary artery, or coronaries. PMID:27034853

  13. The Supportive Chair.

    ERIC Educational Resources Information Center

    Rosbottom, Ronald C.

    1987-01-01

    Recommendations for chairs of college-level foreign language departments include: being supportive of the department; communicating fully and openly with faculty and staff; promoting grantsmanship; and encouraging staff and faculty. Recommendations for deans working with chairs and department heads include: consulting frequently and communicating…

  14. Respiratory Conditions Update: Asthma.

    PubMed

    Zeller, Timothy A

    2016-09-01

    Asthma is a chronic respiratory disease characterized by chronic airway inflammation and variable expiratory airflow limitation. Related clinical features include wheezing, dyspnea, chest tightness, and cough that worsens at night or in the early morning, and that varies over time and in intensity. A finding of variable expiratory airflow limitation on spirometry confirms the diagnosis. A forced expiratory volume in 1 second to forced vital capacity ratio less than the level predicted for the patient's age is suggestive of airflow limitation. Variability also must be confirmed. Updated guidelines recommend control-based management administered in a stepwise manner, with goals of achieving symptom control and minimizing the risks of exacerbations, future fixed airway limitation, and adverse effects of therapy. There is good evidence for the effectiveness of asthma education and self-management plans. Short-acting bronchodilators should be used as needed for symptom relief, with the addition of an inhaled corticosteroid early as maintenance therapy if symptoms are not well controlled. If asthma remains uncontrolled despite therapy, patients should be referred for more specialized treatment. Biomarkers, biologic drugs, and endoscopic treatments are being studied in the management of severe asthma, and ongoing research may determine which patients might benefit most from these emerging therapies. PMID:27576231

  15. Update on Vascular Dementia.

    PubMed

    Khan, Ayesha; Kalaria, Raj N; Corbett, Anne; Ballard, Clive

    2016-09-01

    Vascular dementia (VaD) is a major contributor to the dementia syndrome and is described as having problems with reasoning, planning, judgment, and memory caused by impaired blood flow to the brain and damage to the blood vessels resulting from events such as stroke. There are a variety of etiologies that contribute to the development of vascular cognitive impairment and VaD, and these are often associated with other dementia-related pathologies such as Alzheimer disease. The diagnosis of VaD is difficult due to the number and types of lesions and their locations in the brain. Factors that increase the risk of vascular diseases such as stroke, high blood pressure, high cholesterol, and smoking also raise the risk of VaD. Therefore, controlling these risk factors can help lower the chances of developing VaD. This update describes the subtypes of VaD, with details of their complex presentation, associated pathological lesions, and issues with diagnosis, prevention, and treatment. PMID:27502303

  16. Dali server update.

    PubMed

    Holm, Liisa; Laakso, Laura M

    2016-07-01

    The Dali server (http://ekhidna2.biocenter.helsinki.fi/dali) is a network service for comparing protein structures in 3D. In favourable cases, comparing 3D structures may reveal biologically interesting similarities that are not detectable by comparing sequences. The Dali server has been running in various places for over 20 years and is used routinely by crystallographers on newly solved structures. The latest update of the server provides enhanced analytics for the study of sequence and structure conservation. The server performs three types of structure comparisons: (i) Protein Data Bank (PDB) search compares one query structure against those in the PDB and returns a list of similar structures; (ii) pairwise comparison compares one query structure against a list of structures specified by the user; and (iii) all against all structure comparison returns a structural similarity matrix, a dendrogram and a multidimensional scaling projection of a set of structures specified by the user. Structural superimpositions are visualized using the Java-free WebGL viewer PV. The structural alignment view is enhanced by sequence similarity searches against Uniprot. The combined structure-sequence alignment information is compressed to a stack of aligned sequence logos. In the stack, each structure is structurally aligned to the query protein and represented by a sequence logo. PMID:27131377

  17. Update in Internal Medicine

    PubMed Central

    López-Jiménez, Francisco; Brito, Máximo; Aude, Y. Wady; Scheinberg, Phillip; Kaplan, Mariana; Dixon, Denise A.; Schneiderman, Neil; Trejo, Jorge F.; López-Salazar, Luis Humberto; Ramírez-Barba, Ector Jaime; Kalil, Roberto; Ortiz, Carmen; Goyos, José; Buenaño, Alvaro; Kottiech, Samer; Lamas, Gervasio A.

    2009-01-01

    More than 500,000 new medical articles are published every year and available time to keep updated is scarcer every day. Nowadays, the task of selecting useful, consistent, and relevant information for clinicians is a priority in many major medical journals. This review has the aim of gathering the results of the most important findings in clinical medicine in the last few years. It is focused on results from randomized clinical trials and well-designed observational research. Findings were included preferentially if they showed solid results, and we avoided as much as possible including only preliminary data, or results that included only non-clinical outcomes. Some of the most relevant findings reported here include the significant benefit of statins in patients with coronary artery disease even with mean cholesterol level. It also provides a substantial review of the most significant trials assessing the effectiveness of IIb/IIIa receptor blockers. In gastroenterology many advances have been made in the H. pylori eradication, and the finding that the cure of H. pylori infection may be followed by gastroesophageal reflux disease. Some new antivirals have shown encouraging results in patients with chronic hepatitis. In the infectious disease arena, the late breaking trials in anti-retroviral disease are discussed, as well as the new trends regarding antibiotic resistance. This review approaches also the role of leukotriene modifiers in the treatment of asthma and discusses the benefit of using methylprednisolone in patients with adult respiratory distress syndrome, among many other advances in internal medicine. PMID:11068074

  18. Update on PISCES

    NASA Technical Reports Server (NTRS)

    Pearson, Don; Hamm, Dustin; Kubena, Brian; Weaver, Jonathan K.

    2010-01-01

    An updated version of the Platform Independent Software Components for the Exploration of Space (PISCES) software library is available. A previous version was reported in Library for Developing Spacecraft-Mission-Planning Software (MSC-22983), NASA Tech Briefs, Vol. 25, No. 7 (July 2001), page 52. To recapitulate: This software provides for Web-based, collaborative development of computer programs for planning trajectories and trajectory- related aspects of spacecraft-mission design. The library was built using state-of-the-art object-oriented concepts and software-development methodologies. The components of PISCES include Java-language application programs arranged in a hierarchy of classes that facilitates the reuse of the components. As its full name suggests, the PISCES library affords platform-independence: The Java language makes it possible to use the classes and application programs with a Java virtual machine, which is available in most Web-browser programs. Another advantage is expandability: Object orientation facilitates expansion of the library through creation of a new class. Improvements in the library since the previous version include development of orbital-maneuver- planning and rendezvous-launch-window application programs, enhancement of capabilities for propagation of orbits, and development of a desktop user interface.

  19. [Emergency departments - 2016 update].

    PubMed

    Zimmermann, M; Brokmann, J C; Gräff, I; Kumle, B; Wilke, P; Gries, A

    2016-04-01

    Acute medical care in hospital emergency departments has experienced rapid development in recent years and gained increasing importance not only from a professional medical point of view but also from an economic and health policy perspective. The present article therefore provides an update on the situation of emergency departments in Germany. Care in emergency departments is provided with an increasing tendency to patients of all ages presenting with varying primary symptoms, complaints, illnesses and injury patterns. In the process, patients reach the emergency department by various routes and structural provision. Cross-sectional communication and cooperation, prioritization and organization of emergency management and especially medical staff qualifications increasingly play a decisive role in this process. The range of necessary knowledge and skills far exceeds the scope of prehospital medical emergency care and the working environment differs substantially. In addition to existing structural and economic problems, the latest developments, as well as future proposals for the design of in-hospital emergency medical care in interdisciplinary emergency departments are described. PMID:26952123

  20. The X-33 Program Update

    NASA Technical Reports Server (NTRS)

    Dill, Charlie

    2000-01-01

    This viewgraph presentation gives an overview of the X-33 program update, including details on program objectives and plans, the X-33 configuration, technologies used, and X-33 assembly and test status.

  1. Gearbox Reliability Collaborative Update (Presentation)

    SciTech Connect

    Sheng, S.

    2013-10-01

    This presentation was given at the Sandia Reliability Workshop in August 2013 and provides information on current statistics, a status update, next steps, and other reliability research and development activities related to the Gearbox Reliability Collaborative.

  2. ISS Update: Transit of Venus

    NASA Video Gallery

    ISS Update commentator Brandi Dean interviews Mario Runco, NASA astronaut, about Venus's transit across the sun on June 5, 2012. Questions? Ask us on Twitter @NASA_Johnson and include the hashtag #...

  3. Email Updates: MedlinePlus

    MedlinePlus

    ... MedlinePlus emails from being marked as "spam" or "junk" To ensure that MedlinePlus email updates are delivered ... our emails from being marked as "spam" or "junk." About MedlinePlus Site Map FAQs Contact Us Get ...

  4. An interval model updating strategy using interval response surface models

    NASA Astrophysics Data System (ADS)

    Fang, Sheng-En; Zhang, Qiu-Hu; Ren, Wei-Xin

    2015-08-01

    Stochastic model updating provides an effective way of handling uncertainties existing in real-world structures. In general, probabilistic theories, fuzzy mathematics or interval analyses are involved in the solution of inverse problems. However in practice, probability distributions or membership functions of structural parameters are often unavailable due to insufficient information of a structure. At this moment an interval model updating procedure shows its superiority in the aspect of problem simplification since only the upper and lower bounds of parameters and responses are sought. To this end, this study develops a new concept of interval response surface models for the purpose of efficiently implementing the interval model updating procedure. The frequent interval overestimation due to the use of interval arithmetic can be maximally avoided leading to accurate estimation of parameter intervals. Meanwhile, the establishment of an interval inverse problem is highly simplified, accompanied by a saving of computational costs. By this means a relatively simple and cost-efficient interval updating process can be achieved. Lastly, the feasibility and reliability of the developed method have been verified against a numerical mass-spring system and also against a set of experimentally tested steel plates.

  5. Tourette's Disorder: Genetic Update, Neurological Correlates, and Evidence-Based Interventions

    ERIC Educational Resources Information Center

    Phelps, LeAdelle

    2008-01-01

    This article provides an update of the search for genetic markers related to Tourette's Disorder. The probable neurophysiology of the disorder is reviewed. Frequently prescribed medications are related to the probable biological bases of the disorder. Behavioral interventions and assessment tools are examined. It is concluded that evidence based…

  6. Frequent underwater volcanism in the central Aegean Sea

    NASA Astrophysics Data System (ADS)

    Huebscher, C.; Ruhnau, M.; Dehghani, G. A.

    2012-04-01

    The extinction of the Minoan culture in the mid second millennium BCE is a well known consequence of the Plinian eruption of Thera volcano (Santorini Island). Santorini is a member of the South Aegean arc forming a chain from the Gulf of Saronikos (Susaki, Egina, Poros, Methana) at West, to an area close to the Anatolian coast at East (Kos, Nisyros and minor islands), through the central part (Milos and Santorini island groups). Underwater volcanic activity was manifested historically only once. During 1649-1650 CE the Kolumbo underwater volcano evolved about 8 km northeast of Santorini. As a consequence of this eruption volcanic ash covered the entire Aegean area and a hazardous tsunami was triggered. Here we show by means of reflection seismic and magnetic data that underwater volcanism occurred more frequently in the central Aegean Sea than previously assumed. Seismic data show that Kolumbo constitutes of five vertically stacked cones of pyroclastic sediment plus at least four smaller cones on the flank of the volcano. The formation of Kolumbo started synchronous with Santorini Island. The entire volume of the Kolumbo pyroclastic cones is estimated to more than 15 cubic-kilometers. Several small-scale cones have been detected in the Anyhdros Basin some km north-east of Kolumbo, being previously interpreted as mud volcanoes by other authors. However, the similarity of seismic and magnetic signatures of these cones and Kolumbo strongly suggest that these cones were also created by underwater volcanism. Volcanic cones, Kolumbo and Santorini are situated along a NE-SW striking graben system that evolved during five extensional tectonic pulses in the Pliocene.

  7. Frequent transmission of immunodeficiency viruses among bobcats and pumas

    USGS Publications Warehouse

    Franklin, S.P.; Troyer, J.L.; TerWee, J.A.; Lyren, L.M.; Boyce, W.M.; Riley, S.P.D.; Roelke, M.E.; Crooks, K.R.; VandeWoude, S.

    2007-01-01

    With the exception of human immunodeficiency virus (HIV), which emerged in humans after cross-species transmissions of simian immunodeficiency viruses from nonhuman primates, immunodeficiency viruses of the family Lentiviridae represent species-specific viruses that rarely cross species barriers to infect new hosts. Among the Felidae, numerous immunodeficiency-like lentiviruses have been documented, but only a few cross-species transmissions have been recorded, and these have not been perpetuated in the recipient species. Lentivirus seroprevalence was determined for 79 bobcats (Lynx rufus) and 31 pumas (Puma concolor) from well-defined populations in Southern California. Partial genomic sequences were subsequently obtained from 18 and 12 seropositive bobcats and pumas, respectively. Genotypes were analyzed for phylogenic relatedness and genotypic composition among the study set and archived feline lentivirus sequences. This investigation of feline immunodeficiency virus infection in bobcats and pumas of Southern California provides evidence that cross-species infection has occurred frequently among these animals. The data suggest that transmission has occurred in multiple locations and are most consistent with the spread of the virus from bobcats to pumas. Although the ultimate causes remain unknown, these transmission events may occur as a result of puma predation on bobcats, a situation similar to that which fostered transmission of HIV to humans, and likely represent the emergence of a lentivirus with relaxed barriers to cross-species transmission. This unusual observation provides a valuable opportunity to evaluate the ecological, behavioral, and molecular conditions that favor repeated transmissions and persistence of lentivirus between species. Copyright ?? 2007, American Society for Microbiology. All Rights Reserved.

  8. Lymphedema following cancer therapy in Slovenia: a frequently overlooked condition?

    PubMed Central

    Rucigaj, Tanja Planinsek; Leskovec, Nada Kecelj; Zunter, Vesna Tlaker

    2010-01-01

    Introduction Secondary lymphedema following cancer therapy is a frequent, often painful, quality of life disturbing condition, reducing the patients’ mobility and predisposing them to complications, e.g. infections and malignancies. The critical aspect of lymphedema therapy is to start as soon as possible to prevent the irreversible tissue damage. Patients and methods We performed a retrospective study of patients with lymphedema, treated at the Department of Dermatovenereology, University Medical Center Ljubljana, from January 2002 to June 2010. The patients’ demographic and medical data were collected, including type of cancer, type and stage of lymphedema, and time to first therapy of lymphedema. The number of referred patients with lymphedema following the therapy of melanoma, breast cancer, and uterine/cervical cancer, was compared to the number of patients expected to experience lymphedema following cancer therapy, calculated from the incidence reported in the literature. Results In the period of 8.5 years, 543 patients (432 females, 112 males) with lymphedema were treated. The results show that probably many Slovenian patients with secondary lymphedema following cancer therapy remain unrecognized and untreated or undertreated. In the majority of our patients, the management of lymphedema was delayed; on average, the patients first received therapy for lymphedema 3.6 years after the first signs of lymphedema. Conclusions To avoid a delay in diagnosis and therapy, and the complications of lymphedema following cancer therapy, the physician should actively look for signs or symptoms of lymphedema during the follow-up period, and promptly manage or refer the patients developing problems. PMID:22933923

  9. [Adherence to chronic medication: also a frequent problem in Belgium!].

    PubMed

    Liekens, S; Hulshagen, L; Dethier, M; Laekeman, G; Foulon, V

    2013-12-01

    Medication adherence in chronic conditions such as asthma, type 2 diabetes, heart failure, HIV and cancer appears to be a frequent problem. However, the literature on adherence in patients who use inhaled corticosteroids (ICS), oral hypoglycemic agents, drugs for heart failure, antiretrovirals or oral chemotherapy, contains little or no relevant data for Belgium. In the context of a Master thesis in Pharmaceutical care at KU Leuven, a quantitative study was performed to determine the prevalence of adherence to chronic medication in Belgium. This retrospective, cross-sectional study used a database containing refill data of a regional pharmacists' association (KLAV). Out of the 603 pharmacies affiliated with this association, all 50 pharmacies where HIV medication was delivered, were selected. Dispensing data from the selected pharmacies were collected from 01/07/2008 to 31/12/2009 for five pathologies, i.e.; asthma, type 2 diabetes, heart failure, HIV and cancer. Adherence (TT) was calculated with the Medication Refill Adherence (MRA) method. In order to determine whether there were associations between age, gender, drug class and adherence, Chi-square tests were used. Compared with the other patients, cancer patients were the most adherent in taking their drugs (median adherence rate = 88%). In addition, this was the only group in which the median adherence rate was above the set limit of 80%. The patients who were prescribed inhaled corticosteroids were the least adherent (median adherence rate = 38%). More than 50% of patients with asthma/COPD, heart failure and diabetes were classified as "under-users". Furthermore, the results showed a significant association within asthma patients between gender and adherence. In asthma, type 2 diabetes, heart failure and HIV patients there was a significant relationship between age and adherence and drug class and adherence. As the current study has some limitations, the results should be handled with caution. Nevertheless

  10. Dermal fillers: an update.

    PubMed

    Ballin, Annelyse Cristine; Brandt, Fredric S; Cazzaniga, Alex

    2015-08-01

    Injection of dermal fillers is the second most frequent nonsurgical cosmetic procedure performed in the USA. Dermal fillers are an option in the treatment of volume deficiency, scars, and rhytides; facial sculpting; facial contouring; and augmentation of specific anatomical sites such as the lips. The number of injectable dermal fillers available on the market increases yearly. Dermatologists and cosmetic surgeons should regularly review treatment options to provide patients with safe and effective filler options. This paper extensively reviews the properties of the available fillers, such as their rheology, longevity, and adverse effects, and how these properties affect the choice of filler agent for a particular patient or a particular site. Also, trends in dermal filler injections are discussed. PMID:26081021

  11. Modes of Fatty Acid Desaturation in Cyanobacteria: An Update

    PubMed Central

    Los, Dmitry A.; Mironov, Kirill S.

    2015-01-01

    Fatty acid composition of individual species of cyanobacteria is conserved and it may be used as a phylogenetic marker. The previously proposed classification system was based solely on biochemical data. Today, new genomic data are available, which support a need to update a previously postulated FA-based classification of cyanobacteria. These changes are necessary in order to adjust and synchronize biochemical, physiological and genomic data, which may help to establish an adequate comprehensive taxonomic system for cyanobacteria in the future. Here, we propose an update to the classification system of cyanobacteria based on their fatty acid composition. PMID:25809965

  12. NPOESS Field Terminal Updates

    NASA Astrophysics Data System (ADS)

    Heckmann, G.; Route, G.

    2009-12-01

    The National Oceanic and Atmospheric Administration (NOAA), Department of Defense (DoD), and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation weather and environmental satellite system; the National Polar-orbiting Operational Environmental Satellite System (NPOESS). NPOESS replaces the current Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA and the Defense Meteorological Satellite Program (DMSP) managed by the DoD. The NPOESS satellites carry a suite of sensors that collect meteorological, oceanographic, climatological, and solar-geophysical observations of the earth, atmosphere, and space. The ground data processing segment for NPOESS is the Interface Data Processing Segment (IDPS), developed by Raytheon Intelligence and Information Systems. The IDPS processes NPOESS satellite data to provide environmental data products (aka, Environmental Data Records or EDRs) to NOAA and DoD processing centers operated by the United States government. The IDPS will process EDRs beginning with the NPOESS Preparatory Project (NPP) and continuing through the lifetime of the NPOESS system. IDPS also provides the software and requirements for the Field Terminal Segment (FTS). NPOESS provides support to deployed field terminals by providing mission data in the Low Rate and High Rate downlinks (LRD/HRD), mission support data needed to generate EDRs and decryption keys needed to decrypt mission data during Selective data Encryption (SDE). Mission support data consists of globally relevant data, geographically constrained data, and two line element sets. NPOESS provides these mission support data via the Internet accessible Mission Support Data Server and HRD/LRD downlinks. This presentation will illustrate and describe the NPOESS capabilities in support of Field Terminal users. This discussion will include the mission support data available to Field Terminal users, content of the direct broadcast HRD and LRD

  13. CREME96 Update/Replacement Efforts

    NASA Technical Reports Server (NTRS)

    Adams, Jim H.

    2007-01-01

    This talk concerns the plans to update the CREME96 model that is currently available on the WWW. The talk states the reasons for updating C REME. It describes the updates that are planned, including the single event prediction paradigm, the method of radiation transport through the spacecraft to the electronic component of interest and the planned updates to models for the space radiation environment. It also revi ews user suggestions received do date for the update.

  14. A web-services architecture designed for intermittent connectivity to support medical response to disasters.

    PubMed

    Brown, Steve; Griswold, William; Lenert, Leslie A

    2005-01-01

    To support mobile computing systems for first responders at mass casualty sites, as part of the WIISARD (Wireless Internet Information System for Medical Response in Disasters) project, we have developed a data architecture to gracefully handle an environment with frequent network failure and, multiple writers that also supports rapid dissemination of updates that could be critical to the safety of responders. This is accomplished by allowing for a subset of the overall information available in a disaster scene to be cached locally on a responder's device and locally modified with or without network access. When the network is available, the local subset of the model is automatically synchronized with a server that contains the full model, and conflicts are resolved. When changes from a device are committed, the changes are instantly sent to any connected devices where the local subset would be modified by the changes. PMID:16779191

  15. UCbase 2.0: ultraconserved sequences database (2014 update)

    PubMed Central

    Lomonaco, Vincenzo; Martoglia, Riccardo; Mandreoli, Federica; Anderlucci, Laura; Emmett, Warren; Bicciato, Silvio; Taccioli, Cristian

    2014-01-01

    UCbase 2.0 (http://ucbase.unimore.it) is an update, extension and evolution of UCbase, a Web tool dedicated to the analysis of ultraconserved sequences (UCRs). UCRs are 481 sequences >200 bases sharing 100% identity among human, mouse and rat genomes. They are frequently located in genomic regions known to be involved in cancer or differentially expressed in human leukemias and carcinomas. UCbase 2.0 is a platform-independent Web resource that includes the updated version of the human genome annotation (hg19), information linking disorders to chromosomal coordinates based on the Systematized Nomenclature of Medicine classification, a query tool to search for Single Nucleotide Polymorphisms (SNPs) and a new text box to directly interrogate the database using a MySQL interface. To facilitate the interactive visual interpretation of UCR chromosomal positioning, UCbase 2.0 now includes a graph visualization interface directly linked to UCSC genome browser. Database URL: http://ucbase.unimore.it PMID:24951797

  16. UCbase 2.0: ultraconserved sequences database (2014 update).

    PubMed

    Lomonaco, Vincenzo; Martoglia, Riccardo; Mandreoli, Federica; Anderlucci, Laura; Emmett, Warren; Bicciato, Silvio; Taccioli, Cristian

    2014-01-01

    UCbase 2.0 (http://ucbase.unimore.it) is an update, extension and evolution of UCbase, a Web tool dedicated to the analysis of ultraconserved sequences (UCRs). UCRs are 481 sequences >200 bases sharing 100% identity among human, mouse and rat genomes. They are frequently located in genomic regions known to be involved in cancer or differentially expressed in human leukemias and carcinomas. UCbase 2.0 is a platform-independent Web resource that includes the updated version of the human genome annotation (hg19), information linking disorders to chromosomal coordinates based on the Systematized Nomenclature of Medicine classification, a query tool to search for Single Nucleotide Polymorphisms (SNPs) and a new text box to directly interrogate the database using a MySQL interface. To facilitate the interactive visual interpretation of UCR chromosomal positioning, UCbase 2.0 now includes a graph visualization interface directly linked to UCSC genome browser. Database URL: http://ucbase.unimore.it. PMID:24951797

  17. A last updating evolution model for online social networks

    NASA Astrophysics Data System (ADS)

    Bu, Zhan; Xia, Zhengyou; Wang, Jiandong; Zhang, Chengcui

    2013-05-01

    As information technology has advanced, people are turning to electronic media more frequently for communication, and social relationships are increasingly found on online channels. However, there is very limited knowledge about the actual evolution of the online social networks. In this paper, we propose and study a novel evolution network model with the new concept of “last updating time”, which exists in many real-life online social networks. The last updating evolution network model can maintain the robustness of scale-free networks and can improve the network reliance against intentional attacks. What is more, we also found that it has the “small-world effect”, which is the inherent property of most social networks. Simulation experiment based on this model show that the results and the real-life data are consistent, which means that our model is valid.

  18. Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology

    PubMed Central

    2011-01-01

    Background Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this study was to determine the incidence of acute leukemia in children who were diagnosed and treated in public hospitals in Mexico City. Methods Included in this study were those children, under 15 years of age and residents of Mexico City, who were diagnosed in 2006 and 2007 with leukemia, as determined by using the International Classification of Childhood Cancer. The average annual incidence rates (AAIR), and the standardized average annual incidence rates (SAAIR) per million children were calculated. We calculated crude, age- and sex-specific incidence rates and adjusted for age by the direct method with the world population as standard. We determined if there were a correlation between the incidence of acute leukemias in the various boroughs of Mexico City and either the number of agricultural hectares, the average number of persons per household, or the municipal human development index for Mexico (used as a reference of socio-economic level). Results Although a total of 610 new cases of leukemia were registered during 2006-2007, only 228 fit the criteria for inclusion in this study. The overall SAAIR was 57.6 per million children (95% CI, 46.9-68.3); acute lymphoblastic leukemia (ALL) was the most frequent type of leukemia, constituting 85.1% of the cases (SAAIR: 49.5 per million), followed by acute myeloblastic leukemia at 12.3% (SAAIR: 6.9 per million), and chronic myeloid leukemia at 1.7% (SAAIR: 0.9 per million). The 1-4 years age group had the highest SAAIR for ALL (77.7 per million). For cases of ALL, 73.2% had precursor B-cell immunophenotype (SAAIR: 35.8 per million) and 12.4% had T-cell immunophenotype (SAAIR 6.3 per million). The peak ages for ALL were 2-6 years and 8-10 years. More than half the children (58.8%) were classified as high

  19. An Update on the CDDIS

    NASA Technical Reports Server (NTRS)

    Noll, Carey; Michael, Patrick; Dube, Maurice P.; Pollack, N.

    2012-01-01

    The Crustal Dynamics Data Inforn1ation System (CoorS) supports data archiving and distribution activities for the space geodesy and geodynamics community. The main objectives of the system are to store space geodesy and geodynamics related data products in a central data bank, to maintain infom1ation about the archival of these data, and to disseminate these data and information in a timely mam1er to a global scientific research community. The archive consists of GNSS, laser ranging, VLBI, and OORIS data sets and products derived from these data. The coors is one of NASA's Earth Observing System Oata and Infom1ation System (EOSorS) distributed data centers; EOSOIS data centers serve a diverse user community and are tasked to provide facilities to search and access science data and products. The coors data system and its archive have become increasingly important to many national and international science communities, in pal1icular several of the operational services within the International Association of Geodesy (lAG) and its project the Global Geodetic Observing System (GGOS), including the International OORIS Service (IDS), the International GNSS Service (IGS), the International Laser Ranging Service (ILRS), the International VLBI Service for Geodesy and Astrometry (IVS), and the International Earth Rotation Service (IERS). The coors has recently expanded its archive to supp011 the IGS Multi-GNSS Experiment (MGEX). The archive now contains daily and hourly 3D-second and subhourly I-second data from an additional 35+ stations in RINEX V3 fOm1at. The coors will soon install an Ntrip broadcast relay to support the activities of the IGS Real-Time Pilot Project (RTPP) and the future Real-Time IGS Service. The coors has also developed a new web-based application to aid users in data discovery, both within the current community and beyond. To enable this data discovery application, the CDDIS is currently implementing modifications to the metadata extracted from

  20. Updated NGNP Fuel Acquisition Strategy

    SciTech Connect

    David Petti; Tim Abram; Richard Hobbins; Jim Kendall

    2010-12-01

    A Next Generation Nuclear Plant (NGNP) fuel acquisition strategy was first established in 2007. In that report, a detailed technical assessment of potential fuel vendors for the first core of NGNP was conducted by an independent group of international experts based on input from the three major reactor vendor teams. Part of the assessment included an evaluation of the credibility of each option, along with a cost and schedule to implement each strategy compared with the schedule and throughput needs of the NGNP project. While credible options were identified based on the conditions in place at the time, many changes in the assumptions underlying the strategy and in externalities that have occurred in the interim requiring that the options be re-evaluated. This document presents an update to that strategy based on current capabilities for fuel fabrication as well as fuel performance and qualification testing worldwide. In light of the recent Pebble Bed Modular Reactor (PBMR) project closure, the Advanced Gas Reactor (AGR) fuel development and qualification program needs to support both pebble and prismatic options under the NGNP project. A number of assumptions were established that formed a context for the evaluation. Of these, the most important are: • Based on logistics associated with the on-going engineering design activities, vendor teams would start preliminary design in October 2012 and complete in May 2014. A decision on reactor type will be made following preliminary design, with the decision process assumed to be completed in January 2015. Thus, no fuel decision (pebble or prismatic) will be made in the near term. • Activities necessary for both pebble and prismatic fuel qualification will be conducted in parallel until a fuel form selection is made. As such, process development, fuel fabrication, irradiation, and testing for pebble and prismatic options should not negatively influence each other during the period prior to a decision on reactor type

  1. DOE interpretations Guide to OSH standards. Update to the Guide

    SciTech Connect

    Not Available

    1994-03-31

    Reflecting Secretary O`Leary`s focus on occupational safety and health, the Office of Occupational Safety is pleased to provide you with the latest update to the DOE Interpretations Guide to OSH Standards. This Guide was developed in cooperation with the Occupational Safety and Health Administration, which continued its support during this last revision by facilitating access to the interpretations found on the OSHA Computerized Information System (OCIS). This March 31, 1994 update contains 123 formal interpretation letters written OSHA. As a result of the unique requests received by the 1-800 Response Line, this update also contains 38 interpretations developed by DOE. This new occupational safety and health information adds still more important guidance to the four volume reference set that you presently have in your possession.

  2. DOE interpretations Guide to OSH standards. Update to the Guide

    SciTech Connect

    Not Available

    1994-03-31

    Reflecting Secretary O`Leary`s focus on occupational safety and health, the Office of Occupational Safety is pleased to provide you with the latest update to the DOE Interpretations Guide to OSH Standards. This Guide was developed in cooperation with the Occupational Safety and Health Administration, which continued it`s support during this last revision by facilitating access to the interpretations found on the OSHA Computerized Information System (OCIS). This March 31, 1994 update contains 123 formal in letter written by OSHA. As a result of the unique requests received by the 1-800 Response Line, this update also contains 38 interpretations developed by DOE. This new occupational safety and health information adds still more important guidance to the four volume reference set that you presently have in your possession.

  3. DOE interpretations Guide to OSH standards. Update to the Guide

    SciTech Connect

    Not Available

    1994-03-31

    Reflecting Secretary O`Leary`s focus on occupational safety and health, the Office of Occupational Safety is pleased to provide you with the latest update to the DOE Interpretations Guide to OSH Standards. This Guide was developed in cooperation with the Occupational Safety and Health Administration, which continued its support during this last revision by facilitating access to the interpretations found on the OSHA Computerized Information System (OCIS). This March 31, 1994 update contains 123 formal interpretation letters written by OSHA. As a result of the unique requests received by the 1-800 Response Line, this update also contains 38 interpretations developed by DOE. This new occupational safety and health information adds still more important guidance to the four volume reference set that you presently have in your possession.

  4. Transaction rules for updating surfaces in 3D GIS

    NASA Astrophysics Data System (ADS)

    Gröger, Gerhard; Plümer, Lutz

    2012-04-01

    Three-dimensional surface models representing the terrain and the outer hull of objects such as buildings and bridges support important 3D GIS applications, for example telecommunication planning and noise emission simulation. Updates of surface models often introduce errors which violate basic assumptions of users and their applications. The notion of geometric-topological consistency covers many of these assumptions. It guarantees that objects do not penetrate mutually or that objects completely cover other objects. Assuring that updates do not violate geometric-topological consistency constitutes a major challenge for 3D GIS which has not been satisfactorily met so far. This article presents a solution which is based on efficient transaction rules for updating 3D surface models. We show that these rules are safe (consistency is preserved by any rule application) and complete (any consistent surface model can be generated by successive rule applications). For both properties rigorous mathematic proofs are given.

  5. Are PPS payments adequate? Issues for updating and assessing rates

    PubMed Central

    Sheingold, Steven H.; Richter, Elizabeth

    1992-01-01

    Declining operating margins under Medicare's prospective payment system (PPS) have focused attention on the adequacy of payment rates. The question of whether annual updates to the rates have been too low or cost increases too high has become important. In this article we discuss issues relevant to updating PPS rates and judging their adequacy. We describe a modification to the current framework for recommending annual update factors. This framework is then used to retrospectively assess PPS payment and cost growth since 1985. The preliminary results suggest that current rates are more than adequate to support the cost of efficient care. Also discussed are why using financial margins to evaluate rates is problematic and alternative methods that might be employed. PMID:10127450

  6. Web Site Development Support

    NASA Technical Reports Server (NTRS)

    Abdul, Hameed

    2016-01-01

    This summer I assisted the RPT Program Office in developing a design plan to update their existing website to current NASA web standards. The finished website is intended for the general public, specifically potential customers interested in learning about NASA's chemical rocket test facility capabilities and test assignment process. The goal of the website is to give the public insight about the purpose and function of the RPT Program. Working on this project gave me the opportunity to learn skills necessary for effective project management. The RPT Program Office manages numerous facilities so they are required to travel often to other sites for meetings throughout the year. Maneuvering around the travel schedule of the office and the workload priority of the IT Department proved to be quite the challenge. I overcame the travel schedule of the office by frequently communicating and checking in with my mentor via email and telephone.

  7. BEVALAC operation's update

    SciTech Connect

    Not Available

    1986-01-01

    Information is given on the operation and improvement of the BEVALAC, and about some of the supporting facilities, such as the electronics pool and a living/working facility at the accelerator. The status is given of an upgraded local injector, five individual beam lines, and the Plastic Ball Detector. (LEW)

  8. Update on Canada.

    ERIC Educational Resources Information Center

    Hochstadt, John Webster

    1994-01-01

    Gift planning is increasing in Canada's colleges and universities to offset effects of retrenchment. New annuity vehicles and the emergence of university Crown Foundations offer tax breaks that support private giving to institutions. In addition, a simplified process for gifts is anticipated. (MSE)

  9. NSF FY1982 update: Support for basic research

    NASA Astrophysics Data System (ADS)

    Bell, Peter M.

    When the Appropriation Committees of the House of Representatives and the Senate meet in conference this month, discussion of the Astronomical, Atmospheric, Earth, and Ocean Sciences (AAEO) sections of the National Science Foundation (NSF) will be limited. Both the House and the Senate committees made some slight increases to the Office of Management and Budget requests, and the program by program agreement between the two was unusual.The House appropriation bill, H.R. 4034, provides $70 million over the administration request of $1033.5 million. Of the increase, $44.9 million was added in the area of research and related activities and $25.1 million for science and engineering education.

  10. DSSTOX PROJECT UPDATE: SUPPORTING IMPROVED TOXICO-CHEMOINFORMATICS CAPABILITIES.

    EPA Science Inventory

    DSSTox is serving as a source of high quality structure-annotated toxicity and EPA data files for the new Aggregated Computational Toxicology Resource (ACToR) data repository, under development within the EPA NCCT, which will house in an integrated platform multiple domains of to...

  11. DSSTox Project Update: Supporting Improved Toxico-Chemoinformatics Capabilities

    EPA Science Inventory

    Efforts to improve public access to chemical toxicity information resources and to systematize older toxicity studies, along with significant amounts of new data being generated from high throughput screening (HTS) technologies, have the potential to significantly improve predict...

  12. Basidiobolus haptosporus is frequently associated with the gamasid mite Leptogamasus obesus.

    PubMed

    Werner, Sebastian; Peršoh, Derek; Rambold, Gerhard

    2012-01-01

    Two species of mites inhabiting a pine forest soil were screened for associated fungi. The fungal community composition was assessed in 49 mite and 19 soil samples by environmental PCR with a focus on fungi of the genus Basidiobolus. PCR products of the fungal ITS rRNA gene were analyzed by sub-cloning, RFLP-analysis, and sequencing. Thereby Basidiobolus haptosporus was found for the first time to be frequently associated with the gamasid mite species Leptogamasus obesus, while being absent from the oribatid mite Oppiella subpectinata, and from the surrounding soil. The fungus was isolated in pure culture for a detailed morphological characterization and experimental approaches concerning the nature of this fungus-mite association. The experiments and a supporting microscopic screening of freshly captured gamasid mites revealed no indications for the fungus being localized in the mites' gut or haemocoel, but a single spore was found attached to an individual of L. obesus. However, an exclusive phoretic association does not satisfactorily explain the frequent detection of B. haptosporus DNA on or in L. obesus, and the absence of the fungus from soil samples seems not to be in line with its assumed ecology as a widespread saprobic soil fungus. Therefore, a second host species in the life cycle of B. haptosporus is discussed as a working hypothesis. PMID:22208604

  13. Large Scale Frequent Pattern Mining using MPI One-Sided Model

    SciTech Connect

    Vishnu, Abhinav; Agarwal, Khushbu

    2015-09-08

    In this paper, we propose a work-stealing runtime --- Library for Work Stealing LibWS --- using MPI one-sided model for designing scalable FP-Growth --- {\\em de facto} frequent pattern mining algorithm --- on large scale systems. LibWS provides locality efficient and highly scalable work-stealing techniques for load balancing on a variety of data distributions. We also propose a novel communication algorithm for FP-growth data exchange phase, which reduces the communication complexity from state-of-the-art O(p) to O(f + p/f) for p processes and f frequent attributed-ids. FP-Growth is implemented using LibWS and evaluated on several work distributions and support counts. An experimental evaluation of the FP-Growth on LibWS using 4096 processes on an InfiniBand Cluster demonstrates excellent efficiency for several work distributions (87\\% efficiency for Power-law and 91% for Poisson). The proposed distributed FP-Tree merging algorithm provides 38x communication speedup on 4096 cores.

  14. Spatial updating in area LIP is independent of saccade direction.

    PubMed

    Heiser, Laura M; Colby, Carol L

    2006-05-01

    We explore the world around us by making rapid eye movements to objects of interest. Remarkably, these eye movements go unnoticed, and we perceive the world as stable. Spatial updating is one of the neural mechanisms that contributes to this perception of spatial constancy. Previous studies in macaque lateral intraparietal cortex (area LIP) have shown that individual neurons update, or "remap," the locations of salient visual stimuli at the time of an eye movement. The existence of remapping implies that neurons have access to visual information from regions far beyond the classically defined receptive field. We hypothesized that neurons have access to information located anywhere in the visual field. We tested this by recording the activity of LIP neurons while systematically varying the direction in which a stimulus location must be updated. Our primary finding is that individual neurons remap stimulus traces in multiple directions, indicating that LIP neurons have access to information throughout the visual field. At the population level, stimulus traces are updated in conjunction with all saccade directions, even when we consider direction as a function of receptive field location. These results show that spatial updating in LIP is effectively independent of saccade direction. Our findings support the hypothesis that the activity of LIP neurons contributes to the maintenance of spatial constancy throughout the visual field. PMID:16291805

  15. Tourette Syndrome: Update

    PubMed Central

    HALLETT, Mark

    2015-01-01

    Tourette Syndrome is a disorder characterized by tics. It typically begins in childhood and often improves in adult life. Tics are best described as voluntary movements made automatically so that volition is not ordinarily appreciated. There is frequently an urge, sometimes in the form of a specific sensory feeling (sensory tic), that precedes the tic. Patients say that they make the tic in order to reduce the urge, although shortly after the tic, the urge recurs. The sensory feeling may arise due to defective sensory habituation. Since tics relieve the urge, this can be considered rewarding, and repetition of this behavior may perpetuate the tic as a habit. Tourette Syndrome affects boys more than girls and is associated with attention deficit hyperactivity disorder and obsessive compulsive disorder. Although Tourette Syndrome often appears to be autosomal recessive in inheritance, it has been difficult to find any abnormal genes. There is a loss of inhibition in these patients and recent studies show abnormalities in brain GABA. Certainly there is also an abnormality in dopamine function and dopamine blocking agents are effective therapy. In severe drug-refractory patients, deep brain stimulation can be effective. PMID:25604739

  16. [DGRW update: alcohol addiction].

    PubMed

    Vogelgesang, M

    2011-10-01

    First, epidemiological data and socioeconomic consequences of alcohol addiction are summarized. Research findings, in particular in intervention and evaluation, from 2009-2011 in the field of alcohol addiction treatment are then discussed concerning their relevance for rehabilitation practice. The search was based on PubMed and PSYNDEX. The interventions most frequently evaluated and found most effective in alcohol addiction treatment are cognitive-behavioural interventions. Further topics dealt with are: pharmacological relapse prevention; technologically based therapies (e. g. e-therapy); systemic interventions; 12-steps; effectiveness of addiction treatment as confirmed in large-scale catamnestic studies; treatment of addiction and comorbidity; various subgroups (like elderly people and women); as well as other new and interesting developments such as rehab case management, dovetailing of medical and vocational interventions, stepped-care interventions, rehab management category groups as well as a new focus on individual treatment experiences and the pre-eminence of the therapeutic relationship. Finally, priority areas of future research are described. PMID:21976262

  17. Updated Electronic Testbed System

    NASA Technical Reports Server (NTRS)

    Brewer, Kevin L.

    2001-01-01

    updated Electronic Testbed System.

  18. Finite element modelling and updating of a lively footbridge: The complete process

    NASA Astrophysics Data System (ADS)

    Živanović, Stana; Pavic, Aleksandar; Reynolds, Paul

    2007-03-01

    The finite element (FE) model updating technology was originally developed in the aerospace and mechanical engineering disciplines to automatically update numerical models of structures to match their experimentally measured counterparts. The process of updating identifies the drawbacks in the FE modelling and the updated FE model could be used to produce more reliable results in further dynamic analysis. In the last decade, the updating technology has been introduced into civil structural engineering. It can serve as an advanced tool for getting reliable modal properties of large structures. The updating process has four key phases: initial FE modelling, modal testing, manual model tuning and automatic updating (conducted using specialist software). However, the published literature does not connect well these phases, although this is crucial when implementing the updating technology. This paper therefore aims to clarify the importance of this linking and to describe the complete model updating process as applicable in civil structural engineering. The complete process consisting the four phases is outlined and brief theory is presented as appropriate. Then, the procedure is implemented on a lively steel box girder footbridge. It was found that even a very detailed initial FE model underestimated the natural frequencies of all seven experimentally identified modes of vibration, with the maximum error being almost 30%. Manual FE model tuning by trial and error found that flexible supports in the longitudinal direction should be introduced at the girder ends to improve correlation between the measured and FE-calculated modes. This significantly reduced the maximum frequency error to only 4%. It was demonstrated that only then could the FE model be automatically updated in a meaningful way. The automatic updating was successfully conducted by updating 22 uncertain structural parameters. Finally, a physical interpretation of all parameter changes is discussed. This

  19. HER2 testing in gastric cancer: An update

    PubMed Central

    Abrahao-Machado, Lucas Faria; Scapulatempo-Neto, Cristovam

    2016-01-01

    Human epidermal growth factor receptor 2 (HER2) overexpression is increasingly recognized as a frequent molecular abnormality in gastric and gastroesophageal cancer. With the recent introduction of HER2 molecular targeted therapy for patients with advanced gastric cancer, determination of HER2 status is crucial in order to select patients who may benefit from this treatment. This paper provides an update on our knowledge of HER2 in gastric and gastroesophageal cancer, including the prognostic relevance of HER2, the key differences between HER2 protein expression interpretation in breast and gastric cancer, the detection methods and the immunohistochemistry scoring system. PMID:27217694

  20. Update on Pathologic Diagnosis of Corneal Infections and Inflammations

    PubMed Central

    Vemuganti, Geeta K.; Murthy, Somasheila I.; Das, Sujata

    2011-01-01

    One of the most frequent types of corneal specimen that we received in our pathology laboratory is an excised corneal tissue following keratoplasty. Several of these cases are due to corneal infections or the sequelae, like corneal scar. Advances in the histological and molecular diagnosis of corneal infections and inflammations have resulted in rapid and accurate diagnosis of the infectious agent and in the overall understanding of the mechanisms in inflammatory diseases of the cornea. This review provides an update of histopathological findings in various corneal infections and inflammations. PMID:22224015

  1. HER2 testing in gastric cancer: An update.

    PubMed

    Abrahao-Machado, Lucas Faria; Scapulatempo-Neto, Cristovam

    2016-05-21

    Human epidermal growth factor receptor 2 (HER2) overexpression is increasingly recognized as a frequent molecular abnormality in gastric and gastroesophageal cancer. With the recent introduction of HER2 molecular targeted therapy for patients with advanced gastric cancer, determination of HER2 status is crucial in order to select patients who may benefit from this treatment. This paper provides an update on our knowledge of HER2 in gastric and gastroesophageal cancer, including the prognostic relevance of HER2, the key differences between HER2 protein expression interpretation in breast and gastric cancer, the detection methods and the immunohistochemistry scoring system. PMID:27217694

  2. An update on the management of chronic lumbar discogenic pain.

    PubMed

    Manchikanti, Laxmaiah; Hirsch, Joshua A

    2015-09-01

    Lumbar degenerative disc disease without disc herniation, also known as discogenic pain, is an elusive diagnosis of chronic low back pain. Lumbar provocation discography and fusion surgery have been frequently utilized for several decades as the gold standards for the diagnosis and treatment of symptomatic lumbar discogenic pain, though controversial, based on conjecture, rather than evidence. In addition to lumbar fusion, various other operative and nonoperative modalities of treatments are available in managing chronic lumbar discogenic pain. This review provides an updated assessment of the management of chronic lumbar discogenic pain with a critical look at the many modalities of treatments that are currently available. PMID:26255722

  3. Neural mechanisms of reactivation-induced updating that enhance and distort memory

    PubMed Central

    St. Jacques, Peggy L.; Olm, Christopher; Schacter, Daniel L.

    2013-01-01

    We remember a considerable number of personal experiences because we are frequently reminded of them, a process known as memory reactivation. Although memory reactivation helps to stabilize and update memories, reactivation may also introduce distortions if novel information becomes incorporated with memory. Here we used functional magnetic resonance imaging (fMRI) to investigate the neural mechanisms mediating reactivation-induced updating in memory for events experienced during a museum tour. During scanning, participants were shown target photographs to reactivate memories from the museum tour followed by a novel lure photograph from an alternate tour. Later, participants were presented with target and lure photographs and asked to determine whether the photographs showed a stop they visited during the tour. We used a subsequent memory analysis to examine neural recruitment during reactivation that was associated with later true and false memories. We predicted that the quality of reactivation, as determined by online ratings of subjective recollection, would increase subsequent true memories but also facilitate incorporation of the lure photograph, thereby increasing subsequent false memories. The fMRI results revealed that the quality of reactivation modulated subsequent true and false memories via recruitment of left posterior parahippocampal, bilateral retrosplenial, and bilateral posterior inferior parietal cortices. However, the timing of neural recruitment and the way in which memories were reactivated contributed to differences in whether memory reactivation led to distortions or not. These data reveal the neural mechanisms recruited during memory reactivation that modify how memories will be subsequently retrieved, supporting the flexible and dynamic aspects of memory. PMID:24191059

  4. Statistical evaluation of synchronous spike patterns extracted by frequent item set mining

    PubMed Central

    Torre, Emiliano; Picado-Muiño, David; Denker, Michael; Borgelt, Christian; Grün, Sonja

    2013-01-01

    We recently proposed frequent itemset mining (FIM) as a method to perform an optimized search for patterns of synchronous spikes (item sets) in massively parallel spike trains. This search outputs the occurrence count (support) of individual patterns that are not trivially explained by the counts of any superset (closed frequent item sets). The number of patterns found by FIM makes direct statistical tests infeasible due to severe multiple testing. To overcome this issue, we proposed to test the significance not of individual patterns, but instead of their signatures, defined as the pairs of pattern size z and support c. Here, we derive in detail a statistical test for the significance of the signatures under the null hypothesis of full independence (pattern spectrum filtering, PSF) by means of surrogate data. As a result, injected spike patterns that mimic assembly activity are well detected, yielding a low false negative rate. However, this approach is prone to additionally classify patterns resulting from chance overlap of real assembly activity and background spiking as significant. These patterns represent false positives with respect to the null hypothesis of having one assembly of given signature embedded in otherwise independent spiking activity. We propose the additional method of pattern set reduction (PSR) to remove these false positives by conditional filtering. By employing stochastic simulations of parallel spike trains with correlated activity in form of injected spike synchrony in subsets of the neurons, we demonstrate for a range of parameter settings that the analysis scheme composed of FIM, PSF and PSR allows to reliably detect active assemblies in massively parallel spike trains. PMID:24167487

  5. Tube support

    DOEpatents

    Mullinax, Jerry L.

    1988-01-01

    A tube support for supporting horizontal tubes from an inclined vertical support tube passing between the horizontal tubes. A support button is welded to the vertical support tube. Two clamping bars or plates, the lower edges of one bearing on the support button, are removably bolted to the inclined vertical tube. The clamping bars provide upper and lower surface support for the horizontal tubes.

  6. Simultaneous update of priority structures

    SciTech Connect

    Biswas, J.; Browne, J.C.

    1987-01-01

    To avoid centralized bottlenecks, data structures for multiple computer systems must be simultaneously updatable and yet must have some coherent and consistent state. This can be achieved through judicious partitioning of system data structures and control of access to them in such a manner that (1) either different processes operate upon disjoint segments of a given structure; or (2) processes operate upon the same datum object, in a controlled manner. Partitioning of data structures can be by structure or content. It can also occur at multiple times. In this paper we demonstrate content partitioning of a k-ary tree data structure at runtime, to realize a simultaneously updatable priority queue. The tree algorithms are then generalized to banyan data structures and shown to possess attractive properties of simultaneous update and throughput.

  7. Update on local allergic rhinitis.

    PubMed

    Altıntoprak, Niyazi; Kar, Murat; Bayar Muluk, Nuray; Oktemer, Tugba; Ipci, Kagan; Birdane, Leman; Aricigil, Mitat; Senturk, Mehmet; Bafaqeeh, Sameer Ali; Cingi, Cemal

    2016-08-01

    We here provide an update on the literature regarding local allergic rhinitis (LAR). In reviewing LAR, we have included an updated definition, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment for LAR, as well as the defined research areas for future evidence-based studies. LAR is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators. The localised allergic response of LAR is an important topic for the study of allergies. This review provides an update on the current knowledge of LAR. PMID:27368453

  8. Shuttle autoland support program

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The results of the space shuttle automatic landing support program studies performed from November 1, 1975 to March 31, 1976 were summarized. The following subjects were discussed: (1) software definition review (TAEM pre-final and Autoland only), (2) software definition review (KPIT scheduling), (3) deletion of air data, (4) June 1975 aero data update and check runs, (5) flat turn study, (6) guidance mode switching study, (7) flat turn study-additional data, (8) trajectory shaping study, (9) aero data tolerances, and (10) turbulence model study.

  9. Updated treatment algorithm of pulmonary arterial hypertension.

    PubMed

    Galiè, Nazzareno; Corris, Paul A; Frost, Adaani; Girgis, Reda E; Granton, John; Jing, Zhi Cheng; Klepetko, Walter; McGoon, Michael D; McLaughlin, Vallerie V; Preston, Ioana R; Rubin, Lewis J; Sandoval, Julio; Seeger, Werner; Keogh, Anne

    2013-12-24

    The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes different types of recommendations with varying degrees of scientific evidence. In addition, the algorithm is required to be comprehensive but not too complex, informative yet simple and straightforward. The type of information in the treatment algorithm are heterogeneous including clinical, hemodynamic, medical, interventional, pharmacological and regulatory recommendations. Stakeholders (or users) including physicians from various specialties and with variable expertise in PAH, nurses, patients and patients' associations, healthcare providers, regulatory agencies and industry are often interested in the PAH treatment algorithm for different reasons. These are the considerable challenges faced when proposing appropriate updates to the current evidence-based treatment algorithm.The current treatment algorithm may be divided into 3 main areas: 1) general measures, supportive therapy, referral strategy, acute vasoreactivity testing and chronic treatment with calcium channel blockers; 2) initial therapy with approved PAH drugs; and 3) clinical response to the initial therapy, combination therapy, balloon atrial septostomy, and lung transplantation. All three sections will be revisited highlighting information newly available in the past 5 years and proposing updates where appropriate. The European Society of Cardiology grades of recommendation and levels of evidence will be adopted to rank the proposed treatments. PMID:24355643

  10. Transfer after Working Memory Updating Training

    PubMed Central

    Waris, Otto; Soveri, Anna; Laine, Matti

    2015-01-01

    During the past decade, working memory training has attracted much interest. However, the training outcomes have varied between studies and methodological problems have hampered the interpretation of results. The current study examined transfer after working memory updating training by employing an extensive battery of pre-post cognitive measures with a focus on near transfer. Thirty-one healthy Finnish young adults were randomized into either a working memory training group or an active control group. The working memory training group practiced with three working memory tasks, while the control group trained with three commercial computer games with a low working memory load. The participants trained thrice a week for five weeks, with one training session lasting about 45 minutes. Compared to the control group, the working memory training group showed strongest transfer to an n-back task, followed by working memory updating, which in turn was followed by active working memory capacity. Our results support the view that working memory training produces near transfer effects, and that the degree of transfer depends on the cognitive overlap between the training and transfer measures. PMID:26406319

  11. [Preoperative fasting guidelines: an update].

    PubMed

    López Muñoz, A C; Busto Aguirreurreta, N; Tomás Braulio, J

    2015-03-01

    Anesthesiology societies have issued various guidelines on preoperative fasting since 1990, not only to decrease the incidence of lung aspiration and anesthetic morbidity, but also to increase patient comfort prior to anesthesia. Some of these societies have been updating their guidelines, as such that, since 2010, we now have 2 evidence-based preoperative fasting guidelines available. In this article, an attempt is made to review these updated guidelines, as well as the current instructions for more controversial patients such as infants, the obese, and a particular type of ophthalmic surgery. PMID:25443866

  12. Sustainability Base Construction Update

    NASA Technical Reports Server (NTRS)

    Mewhinney, Michael

    2012-01-01

    Construction of the new Sustainability Base Collaborative support facility, expected to become the highest performing building in the federal government continues at NASA's Ames Research Center, Moffet Field, Calif. The new building is designed to achieve a platinum rating under the leadership in Energy and Environment Design (LEED) new construction standards for environmentally sustainable construction developed by the U. S. Green Building Council, Washington, D. C. When completed by the end of 2011, the $20.6 million building will feature near zero net energy consumption, use 90 percent less potable water than conventionally build buildings of equivalent size, and will result in reduced building maintenance costs.

  13. Forecast Mekong: 2011 update

    USGS Publications Warehouse

    Turnipseed, D. Phil

    2011-01-01

    In 2009, U.S. Secretary of State Hillary R. Clinton joined with the Foreign Ministers of Cambodia, Laos, Thailand, and Vietnam in launching the Lower Mekong Initiative to enhance U.S. engagement with the Lower Mekong countries in the areas of environment, health, education, and infrastructure. Part of the Lower Mekong Initiative, the U.S. Geological Survey's Forecast Mekong project is engaging the United States in scientific research relevant to environmental issues in the Lower Mekong River countries and is staying the course in support of the Mekong Nations with a suite of new projects for 2011.

  14. UPDATE: Applications of Research in Music Education. UPDATE Yearbook

    ERIC Educational Resources Information Center

    Rowman & Littlefield Education, 2005

    2005-01-01

    The Fall 2004 and Spring 2005 issues of "UPDATE: Applications of Research in Music Education," in one print volume, presents hard facts and statistical data in a style that can be easily understood and appreciated by music researchers, teachers, graduates, and undergraduates alike. Includes advice to first-year music teachers, instrument…

  15. Knowledge structure representation and automated updates in intelligent information management systems

    NASA Technical Reports Server (NTRS)

    Corey, Stephen; Carnahan, Richard S., Jr.

    1990-01-01

    A continuing effort to apply rapid prototyping and Artificial Intelligence techniques to problems associated with projected Space Station-era information management systems is examined. In particular, timely updating of the various databases and knowledge structures within the proposed intelligent information management system (IIMS) is critical to support decision making processes. Because of the significantly large amounts of data entering the IIMS on a daily basis, information updates will need to be automatically performed with some systems requiring that data be incorporated and made available to users within a few hours. Meeting these demands depends first, on the design and implementation of information structures that are easily modified and expanded, and second, on the incorporation of intelligent automated update techniques that will allow meaningful information relationships to be established. Potential techniques are studied for developing such an automated update capability and IIMS update requirements are examined in light of results obtained from the IIMS prototyping effort.

  16. Roll back malaria update.

    PubMed

    1999-10-01

    This article presents the activities under WHO's Roll Back Malaria (RBM) program in Asia, particularly in Nepal, Indonesia, India, Bangladesh, Sri Lanka and the Philippines. In India, the RBM program will start in 5 districts with a major malaria problem. A national committee has been formed by researchers, which will be able to provide operational and strategic support and research expertise in relation to malaria. In Bangladesh, the RBM program was initiated in the sparsely populated hill tract areas of Banderban and Chittagong where access to health care is very poor. At the district level, effective partnerships with private practitioners, politicians, community leaders, school teachers, the press and district Ministry of Health officials are operating to plan for rolling back malaria. In Myanmar, Cambodia, Lao People's Democratic Republic, Yunnan province of China, Vietnam, and Thailand, the focus of the RBM program was to move health care closer to the malaria-infected communities. WHO¿s Global Health Leadership Fellowship Programme, supported by the UN Foundation and Rockefeller Foundation, enables potential leaders to experience the work of UN agencies and contribute to the work of the organization for 2 years. Three out of four persons appointed to the RBM program received prestigious awards: Dr. Paola Marchesini of Brazil; Dr. Tieman Diarra of Mali; and Dr. Bob Taylor of the UK. PMID:12295474

  17. [Gout management: an update].

    PubMed

    Ankli, Barbara; Krähenbühl, Stephan

    2016-01-01

    Gout is the most frequent arthritis worldwide. Despite progress in therapeutic options the majority of gout patients are still insufficiently treated. International guidelines (ACR, EULAR, 3e initiative) clearly specify treatment targets: keep the patient flare-free and maintain a low urate serum level (< 360 µmol/l). The treat to target strategy includes therapy of flares, urate lowering treatment (ULT) and prophylaxis of flares. Evolution of gout guidelines over several years shows a broader indication for ULT, mandatory prophylaxis of flares during the initiation of ULT over several months and an earlier start of ULT in patients with flares as soon as symptoms have diminished. Colchicine is the preferred specific flare treatment, Caution has to be taken especially in patients with kidney disease, patients with hepatic dysfunction or in patients with interacting comedication. Low dose oral colchicine is nowadays the standard flare treatment. NSAIDs and prednisone are valuable alternatives. Interleukin-1 blockers offer a quick resolution of flares and may be an option in patients with chronic gout and severe kidney disease. Xanthinoxidase inhibitors (XOI) are the mainstay of ULT, with allopurinol still being the preferred XOI. The recently approved XOI febuxostat is eliminated mostly by the liver and can induce a faster lowering of urate. Uricosuric drugs such as probenecid are recommended in patients with sufficient renal function in whom the treatment goals cannot be reached with XOI. In Switzerland, only the two gout-lowering drugs allopurinol and probenecid are available, which reduces the therapeutic possibilities. Treatment success is often hampered by malcompliance. Recent guidelines stress the importance of patient education to ameliorate compliance. Comorbidities such as metabolic syndrome, cardiovascular and kidney disease are often found in gout patients. Patients with severe kidney disease are the most difficult to treat: the choice of

  18. Breast Cancer and Estrogen-Alone Update

    MedlinePlus

    ... Current Issue Past Issues Research News From NIH Breast Cancer and Estrogen-Alone Update Past Issues / Summer 2006 ... hormone therapy does not increase the risk of breast cancer in postmenopausal women, according to an updated analysis ...

  19. A Machine-Portable CDC UPDATE Emulator.

    Energy Science and Technology Software Center (ESTSC)

    1987-09-01

    Version 01 UPEML is a machine-portable CDC UPDATE emulation program. It is capable of emulating a significant subset of the standard CDC UPDATE functions, including program library creation and subsequent modification.

  20. RELAP-7 Development Updates

    SciTech Connect

    Zhang, Hongbin; Zhao, Haihua; Gleicher, Frederick Nathan; DeHart, Mark David; Zou, Ling; Andrs, David; Martineau, Richard Charles

    2015-09-01

    RELAP-7 is a nuclear systems safety analysis code being developed at the Idaho National Laboratory, and is the next generation tool in the RELAP reactor safety/systems analysis application series. RELAP-7 development began in 2011 to support the Risk Informed Safety Margins Characterization (RISMC) Pathway of the Light Water Reactor Sustainability (LWRS) program. The overall design goal of RELAP-7 is to take advantage of the previous thirty years of advancements in computer architecture, software design, numerical methods, and physical models in order to provide capabilities needed for the RISMC methodology and to support nuclear power safety analysis. The code is being developed based on Idaho National Laboratory’s modern scientific software development framework – MOOSE (the Multi-Physics Object-Oriented Simulation Environment). The initial development goal of the RELAP-7 approach focused primarily on the development of an implicit algorithm capable of strong (nonlinear) coupling of the dependent hydrodynamic variables contained in the 1-D/2-D flow models with the various 0-D system reactor components that compose various boiling water reactor (BWR) and pressurized water reactor nuclear power plants (NPPs). During Fiscal Year (FY) 2015, the RELAP-7 code has been further improved with expanded capability to support boiling water reactor (BWR) and pressurized water reactor NPPs analysis. The accumulator model has been developed. The code has also been coupled with other MOOSE-based applications such as neutronics code RattleSnake and fuel performance code BISON to perform multiphysics analysis. A major design requirement for the implicit algorithm in RELAP-7 is that it is capable of second-order discretization accuracy in both space and time, which eliminates the traditional first-order approximation errors. The second-order temporal is achieved by a second-order backward temporal difference, and the one-dimensional second-order accurate spatial discretization

  1. Renal Ablation Update

    PubMed Central

    Khiatani, Vishal; Dixon, Robert G.

    2014-01-01

    Thermal ablative technologies have evolved considerably in the recent past and are now an important component of current clinical guidelines for the treatment of small renal masses. Both radiofrequency ablation and cryoablation have intermediate-term oncologic control that rivals surgical options, with favorable complication profiles. Studies comparing cryoablation and radiofrequency ablation show no significant difference in oncologic control or complication profile between the two modalities. Early data from small series with microwave ablation have shown similar promising results. Newer technologies including irreversible electroporation and high-intensity–focused ultrasound have theoretical advantages, but will require further research before becoming a routine part of the ablation armamentarium. The purpose of this review article is to discuss the current ablative technologies available, briefly review their mechanisms of action, discuss technical aspects of each, and provide current data supporting their use. PMID:25049445

  2. Renal ablation update.

    PubMed

    Khiatani, Vishal; Dixon, Robert G

    2014-06-01

    Thermal ablative technologies have evolved considerably in the recent past and are now an important component of current clinical guidelines for the treatment of small renal masses. Both radiofrequency ablation and cryoablation have intermediate-term oncologic control that rivals surgical options, with favorable complication profiles. Studies comparing cryoablation and radiofrequency ablation show no significant difference in oncologic control or complication profile between the two modalities. Early data from small series with microwave ablation have shown similar promising results. Newer technologies including irreversible electroporation and high-intensity-focused ultrasound have theoretical advantages, but will require further research before becoming a routine part of the ablation armamentarium. The purpose of this review article is to discuss the current ablative technologies available, briefly review their mechanisms of action, discuss technical aspects of each, and provide current data supporting their use. PMID:25049445

  3. Periviable birth: Interim update.

    PubMed

    Ecker, Jeffrey L; Kaimal, Anjali; Mercer, Brian M; Blackwell, Sean C; deRegnier, Raye Ann O; Farrell, Ruth M; Grobman, William A; Resnik, Jamie L; Sciscione, Anthony C

    2016-08-01

    Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth. These include, but are not limited to, nonmodifiable factors (eg, fetal sex, weight, plurality), potentially modifiable antepartum and intrapartum factors (eg, location of delivery, intent to intervene by cesarean delivery or induction for delivery, administration of antenatal corticosteroids and magnesium sulfate), and postnatal management (eg, starting or withholding and continuing or withdrawing intensive care after birth). Antepartum and intrapartum management options vary depending upon the specific circumstances but may include short-term tocolytic therapy for preterm labor to allow time for administration of antenatal steroids, antibiotics to prolong latency after preterm premature rupture of membranes or for intrapartum group B streptococci prophylaxis, and delivery, including cesarean delivery, for concern regarding fetal well-being or fetal malpresentation. Whenever possible, periviable births for which maternal or neonatal intervention is planned should occur in centers that offer expertise in maternal and neonatal care and the needed infrastructure, including intensive care units, to support such services. This document describes newborn outcomes after periviable birth, provides current evidence and recommendations regarding interventions in this setting, and provides an outline for family counseling with the goal of

  4. Drug Interactions with Lithium: An Update.

    PubMed

    Finley, Patrick R

    2016-08-01

    Lithium has been used for the management of psychiatric illnesses for over 50 years and it continues to be regarded as a first-line agent for the treatment and prevention of bipolar disorder. Lithium possesses a narrow therapeutic index and comparatively minor alterations in plasma concentrations can have significant clinical sequelae. Several drug classes have been implicated in the development of lithium toxicity over the years, including diuretics and non-steroidal anti-inflammatory compounds, but much of the anecdotal and experimental evidence supporting these interactions is dated, and many newer medications and medication classes have been introduced during the intervening years. This review is intended to provide an update on the accumulated evidence documenting potential interactions with lithium, with a focus on pharmacokinetic insights gained within the last two decades. The clinical relevance and ramifications of these interactions are discussed. PMID:26936045

  5. Hubble Space Telescope Battery Capacity Update

    NASA Technical Reports Server (NTRS)

    Hollandsworth, Roger; Armantrout, Jon; Rao, Gopalakrishna M.

    2007-01-01

    Orbital battery performance for the Hubble Space Telescope is discussed and battery life is predicted which supports decision to replace orbital batteries by 2009-2010 timeframe. Ground characterization testing of cells from the replacement battery build is discussed, with comparison of data from battery capacity characterization with cell studies of Cycle Life and 60% Stress Test at the Naval Weapons Surface Center (NWSC)-Crane, and cell Cycle Life testing at the Marshal Space Flight Center (MSFC). The contents of this presentation includes an update to the performance of the on-orbit batteries, as well as a discussion of the HST Service Mission 4 (SM4) batteries manufactured in 1996 and activated in 2000, and a second set of SM4 backup replacement batteries which began manufacture Jan 11, 2007, with delivery scheduled for July 2008.

  6. Antidepressant-induced suicidality: an update.

    PubMed

    Reeves, Roy R; Ladner, Mark E

    2010-08-01

    Evidence suggests that antidepressant treatment may in some cases result in worsening depression and increased risk of suicidality in pediatric and adolescent patients. The United States Food and Drug Administration requires that antidepressants carry a black box warning regarding such a risk in patients up to age 24. Many studies of antidepressant-induced suicidality among adults have also reported an increased risk, while several other investigations involving that population have not supported such a finding. This article provides an update of the controversy surrounding antidepressants as a potential cause of suicidal ideations or behavior. Antidepressant-induced suicidality appears to be an uncommon occurrence but also a legitimate phenomenon. Close monitoring and a follow-up care should be provided for patients after initiation of a new antidepressant. PMID:20553304

  7. An update on PPAR activation by cannabinoids.

    PubMed

    O'Sullivan, Saoirse Elizabeth

    2016-06-01

    Some cannabinoids activate the different isoforms of PPARs (α, β and γ), as shown through the use of reporter gene assays, binding studies, selective antagonists and knockout studies. Activation of all isoforms, but primarily PPARα and γ, mediates some (but not all) of the analgesic, neuroprotective, neuronal function modulation, anti-inflammatory, metabolic, anti-tumour, gastrointestinal and cardiovascular effects of some cannabinoids, often in conjunction with activation of the more traditional target sites of action such as the cannabinoid CB1 and CB2 receptors and the TRPV1 ion channel. PPARs also mediate some of the effects of inhibitors of endocannabinoid degradation or transport. Cannabinoids may be chaperoned to the PPARs by fatty acid binding proteins. The aims of this review are to update the evidence supporting PPAR activation by cannabinoids and to review the physiological responses to cannabinoids that are mediated, and not mediated, by PPAR activation. PMID:27077495

  8. INHERITED NEUROPATHIES: CLINICAL OVERVIEW AND UPDATE

    PubMed Central

    KLEIN, CHRISTOPHER J.; DUAN, XIAOHUI; SHY, MICHAEL E.

    2014-01-01

    Inherited neuropathy is a group of common neurologic disorders with heterogeneous clinical presentations and genetic causes. Detailed neuromuscular evaluations, including nerve conduction studies, laboratory testing, and histopathologic examination, can assist in identification of the inherited component beyond family history. Genetic testing increasingly enables definitive diagnosis of specific inherited neuropathies. Diagnosis, however, is often complex, and neurologic disability may have both genetic and acquired components in individual patients. The decision of which genetic test to order or whether to order genetic tests is often complicated, and the strategies to maximize the value of testing are evolving. Apart from rare inherited metabolic neuropathies, treatment approaches remain largely supportive. We provide a clinical update of the various types of inherited neuropathies, their differential diagnoses, and distinguishing clinical features (where available). A framework is provided for clinical evaluations, including the inheritance assessment, electrophysiologic examinations, and specific genetic tests. PMID:23801417

  9. Preclinical Rheumatoid Arthritis (Autoantibodies): An Updated Review

    PubMed Central

    Deane, Kevin D.

    2014-01-01

    Multiple studies demonstrate that there is a period of development of rheumatoid arthritis (RA) during which there are elevations of disease-related biomarkers, including autoantibodies, in the absence of and prior to the development of RA; this period can be termed ‘preclinical RA’. These ‘preclinical’ autoantibodies including rheumatoid factor and antibodies to citrullinated protein antigens, and more recent studies have also identified a wider variety of autoantibodies and a wide range of inflammatory biomarkers. These findings in conjunction with established and emerging data about genetic and environmental risk factors for RA support a model of disease development where certain factors lead to an initial triggering of RA-related autoimmunity that expands over time to the point where symptomatic arthritis classifiable as RA develops. Herein will be reviewed updates in the field, as well as a discussion of current limitations of our understanding of preclinical RA, and potential future directions for study. PMID:24643396

  10. Community Update, 1998-1999.

    ERIC Educational Resources Information Center

    Anderson, Julie, Ed.

    1999-01-01

    This document consists of ten issues of the newsletter "Community Update," containing articles on community and family involvement in education. Article topics include: a college education is necessary and possible; math and science study points out problems and positive solutions; the "America Reads Challenge"; meeting the Department of…

  11. Task Group 9 Update (Presentation)

    SciTech Connect

    Bosco, N.

    2014-04-01

    This presentation is a brief update of IEC TC82 QA Task Force, Group 9. Presented is an outline of the recently submitted New Work Item Proposal (NWIP) for a Comparative Thermal Cycling Test for CPV Modules to Differentiate Thermal Fatigue Durability.

  12. National Educators' Workshop: Update 1996

    NASA Technical Reports Server (NTRS)

    Gardner, James E.; Freeman, Ginger L.; Jacobs, James; Parkin, Don M.

    1997-01-01

    This document contains a collection of experiments presented and demonstrated at the National Educators' Workshop: Update 96, held at Los Alamos National Laboratory, Los Alamos, New Mexico on October 27-30, 1996. The experiments related to the nature and properties of engineering materials and provided information to assist in teaching about materials in the education community.

  13. NUHOMS{reg_sign} update

    SciTech Connect

    Rich, N.

    1995-12-31

    NUHOMS{reg_sign} is the dry spent fuel storage and transportation technology selected to date by the majority of commercial nuclear utilities. The author first gives a system overview of the NUHOMS{reg_sign}. Next she discusses the project status and licensing status. She closes with an update of the multi-purpose canister.

  14. Community Update, 1997-1998.

    ERIC Educational Resources Information Center

    Anderson, Julie, Ed.

    1998-01-01

    This document consists of 10 issues of the newsletter "Community Update," containing articles on community and family involvement in education. Article topics include: preparing America's future teachers; reports on satellite town meetings; E-rate (education rate) discounts for telecommunications services in schools and libraries; President…

  15. Austin Community College Benchmarking Update.

    ERIC Educational Resources Information Center

    Austin Community Coll., TX. Office of Institutional Effectiveness.

    Austin Community College contracted with MGT of America, Inc. in spring 1999 to develop a peer and benchmark (best) practices analysis on key indicators. These indicators were updated in spring 2002 using data from eight Texas community colleges and four non-Texas institutions that represent large, comprehensive, urban community colleges, similar…

  16. A Mathematics Software Database Update.

    ERIC Educational Resources Information Center

    Cunningham, R. S.; Smith, David A.

    1987-01-01

    Contains an update of an earlier listing of software for mathematics instruction at the college level. Topics are: advanced mathematics, algebra, calculus, differential equations, discrete mathematics, equation solving, general mathematics, geometry, linear and matrix algebra, logic, statistics and probability, and trigonometry. (PK)

  17. Wind turbine reliability database update.

    SciTech Connect

    Peters, Valerie A.; Hill, Roger Ray; Stinebaugh, Jennifer A.; Veers, Paul S.

    2009-03-01

    This report documents the status of the Sandia National Laboratories' Wind Plant Reliability Database. Included in this report are updates on the form and contents of the Database, which stems from a fivestep process of data partnerships, data definition and transfer, data formatting and normalization, analysis, and reporting. Selected observations are also reported.

  18. Censorship in Massachusetts: An Update.

    ERIC Educational Resources Information Center

    Woods, L. B.; O'Brien, Jane E.

    This report updates a 1979 article from the Bay State Librarian about censorship in Massachusetts libraries from 1966 through 1975. Compiled using data from the American Library Association's Office of Intellectual Freedom (OIF), the report provides information about censorship attempts and actions between 1976 and 1982. The definition of…

  19. Competitive Electricity Prices: An Update

    EIA Publications

    1998-01-01

    Illustrates a third impact of the move to competitive generation pricing -- the narrowing of the range of prices across regions of the country. This feature article updates information in Electricity Prices in a Competitive Environment: Marginal Cost Pricing of Generation Services and Financial Status of Electric Utilities.

  20. Deductive Updating Is Not Bayesian

    ERIC Educational Resources Information Center

    Markovits, Henry; Brisson, Janie; de Chantal, Pier-Luc

    2015-01-01

    One of the major debates concerning the nature of inferential reasoning is between counterexample-based theories such as mental model theory and probabilistic theories. This study looks at conclusion updating after the addition of statistical information to examine the hypothesis that deductive reasoning cannot be explained by probabilistic…

  1. Updating the Behavior Engineering Model.

    ERIC Educational Resources Information Center

    Chevalier, Roger

    2003-01-01

    Considers Thomas Gilbert's Behavior Engineering Model as a tool for systematically identifying barriers to individual and organizational performance. Includes a detailed case study and a performance aid that incorporates gap analysis, cause analysis, and force field analysis to update the original model. (Author/LRW)

  2. Progress Update: Stack Project Complete

    ScienceCinema

    Cody, Tom

    2012-06-14

    Progress update from the Savannah River Site. The 75 foot 293 F Stack, built for plutonium production, was cut down to size in order to prevent injury or release of toxic material if the structure were to collapse due to harsh weather.

  3. Energy Education Materials Bibliography - Update.

    ERIC Educational Resources Information Center

    Minnesota State Energy Agency, St. Paul.

    Presented is an updated version of a previous bibliography prepared by the Minnesota State Energy Agency. The materials included in this document are indexed according to grade level and according to whether they are background materials or classroom activities. Each of the items listed were evaluated and included into either the "A" list or the…

  4. National Drug Control Strategy. Update

    ERIC Educational Resources Information Center

    Office of National Drug Control Policy, 2005

    2005-01-01

    The first National Drug Control Strategy set ambitious two and five-year performance based goals: (1) to lower the rate of drug use by 10 percent over 2 years among both youth and adults; and (2) to lower the rate by 25 percent over 5 years. The chapters in this updated version are keyed to the strategies three priorities: (1) Stopping Use Before…

  5. Progress Update: Stack Project Complete

    SciTech Connect

    Cody, Tom

    2010-01-01

    Progress update from the Savannah River Site. The 75 foot 293 F Stack, built for plutonium production, was cut down to size in order to prevent injury or release of toxic material if the structure were to collapse due to harsh weather.

  6. ERIC/IT Update, 2002.

    ERIC Educational Resources Information Center

    ERIC/IT Update, 2002

    2002-01-01

    This document contains two issues of the ERIC Clearinghouse on Information and Technology (ERIC/IT) serial publication, "Update." Each issue includes feature articles; ERIC/IT News; information about new books published in cooperation with ERIC/IT; abstracts of new ERIC Digests, with links to full-text versions of the Digests; a subscription form;…

  7. Vitamin E: Textbooks Require Updating

    ERIC Educational Resources Information Center

    Azzi, Angelo; Zingg, Jean-Marc

    2005-01-01

    Vitamin E was discovered in 1922, but in more than 60 years many new findings have added to the early one. However, its description in many textbooks has not been proportionally updated. The result is an inaccurate, incomplete, and often incorrect description of the function of this vitamin. In some other textbooks, vitamin E is absolutely…

  8. The kidney in heart failure: an update.

    PubMed

    Damman, Kevin; Testani, Jeffrey M

    2015-06-14

    Heart and kidney are closely related in the clinical syndrome of heart failure (HF). It is now sufficiently clear that renal dysfunction occurs frequently in all phenotypes of HF, and when present, it is associated with higher mortality and morbidity. While the pathophysiology is multifactorial, the most important factors are a reduced renal perfusion and venous congestion. Recent interest has focused on worsening renal function (WRF), a situation strongly related to mortality, but seemingly only when HF status deteriorates. Unfortunately, to date clinicians are unable to identify specifically those patients with a grim prognosis following WRF. Although much has been learned on cardiorenal interaction in HF, still more questions have been left unanswered. The coming decade should provide us with more dedicated epidemiologic, mechanistic, and controlled trials in HF patients with reduced renal function. An updated classification of the cardiorenal syndrome that incorporates recent evidence and points towards areas of interest and uncertainties, and areas where progress is needed could facilitate this process. Ultimately, this should lead to preventive and treatment strategies that can preserve renal function and associated outcome in patients with HF. PMID:25838436

  9. 2012 update in the treatment of prolactinomas.

    PubMed

    Maiter, Dominique; Primeau, Vanessa

    2012-04-01

    New information has been provided over the last years regarding treatment of prolactinomas and will be reviewed in this update. Medical treatment with a dopamine agonist (DA) remains the cornerstone of therapy and cabergoline is the first choice, due to its high efficacy and good tolerability profile. Prolonged remission after discontinuation of DA may be observed if treatment has been given for at least two years, normal prolactin has been obtained with a low dose and tumoral diameter has been reduced by at least 50%. Although the risk of restrictive cardiac valve disease is low at the standard doses of cabergoline used for the treatment of hyperprolactinaemia, long-term echocardiographic surveillance is however indicated, in particular in resistant patients who need higher doses of cabergoline (2.0 mg/week or more). Neurosurgical treatment of prolactinomas is less effective than medical therapy and recurrence of hyperprolactinaemia is frequent. Besides classical indications such as drug intolerance, resistance or acute complications, new indications have emerged such as young patients with a high likelihood of complete tumour resection and who do not wish to take prolonged medical treatment, or patients who require high doses of cabergoline, in whom surgical debulking may significantly improve postoperative hormonal control. Finally, recent data indicate that cabergoline is safe for the developing foetus and for the mother, and therefore should not be preventively withdrawn in a young woman wishing to become pregnant. PMID:22503806

  10. Glanzmann's thrombasthenia: updated.

    PubMed

    Nair, Sona; Ghosh, Kanjaksha; Kulkarni, Bipin; Shetty, Shrimati; Mohanty, Dipika

    2002-11-01

    Glanzmann's thrombasthenia is an autosomal recessive disorder, rare in a global context, but a relatively more common platelet function defect in communities where consanguineous marriages are more frequent. On clinical grounds alone, it cannot be distinguished from other congenital platelet function defects. Epistaxis, gum bleeding, menorrhagia are the common clinical manifestations, whereas large muscle hematoma or hemarthrosis seldom occur in these patients. Essential diagnostic features are a normal platelet count and morphology, a greatly prolonged bleeding time, absence of platelet aggregation in response to ADP, collagen, epinephrine, thrombin and to all aggregating agents which ultimately depend on fibrinogen binding to platelets for this effect, flow cytometry, studies of GPIIb-IIIa receptors on the platelet membrane surface using monoclonal antibodies. The present review describes some of the uncommon features of the disorders and the currently available options which the treating physicians should be aware of during the management of these patients. Although by definition all patients with Glanzmann's thrombasthenia have a virtually complete failure of platelet aggregation, a number of variant forms of GT have been described in which the glycoproteins are present in normal or near normal amounts but are functionally defective. Understanding the pathophysiology of the disorder by the treating physicians is of utmost importance. Presence of high affinity platelet receptors resulting in thrombasthennia-like phenotype may require an antagonistic treatment atypical of classical GT management. It has now been established that different genetic mutations of either GPIIb or IIIa genes results in such a heterogeneity of thrombasthenia phenotype. Glanzmann's thrombasthenia is a paradigm for treating coronary artery disease patients with GPIIb-IIIa antibody and inhibitors. By using these medicines we create a temporary GT-like situation. Hence, understanding this

  11. Abu Dhabi Basemap Update Using the LiDAR Mobile Mapping Technology

    NASA Astrophysics Data System (ADS)

    Alshaiba, Omar; Amparo Núñez-Andrés, M.; Lantada, Nieves

    2016-04-01

    Mobile LiDAR system provides a new technology which can be used to update geospatial information by direct and rapid data collection. This technology is faster than the traditional survey ways and has lower cost. Abu Dhabi Municipal System aims to update its geospatial system frequently as the government entities have invested heavily in GIS technology and geospatial data to meet the repaid growth in the infrastructure and construction projects in recent years. The Emirate of Abu Dhabi has witnessed a huge growth in infrastructure and construction projects in recent years. Therefore, it is necessary to develop and update its basemap system frequently to meet their own organizational needs. Currently, the traditional ways are used to update basemap system such as human surveyors, GPS receivers and controller (GPS assigned computer). Then the surveyed data are downloaded, edited and reviewed manually before it is merged to the basemap system. Traditional surveying ways may not be applicable in some conditions such as; bad weather, difficult topographic area and boundary area. This paper presents a proposed methodology which uses the Mobile LiDAR system to update basemap in Abu Dhabi by using daily transactions services. It aims to use and integrate the mobile LiDAR technology into the municipality's daily workflow such that it becomes the new standard cost efficiency operating procedure for updating the base-map in Abu Dhabi Municipal System. On another note, the paper will demonstrate the results of the innovated workflow for the base-map update using the mobile LiDAR point cloud and few processing algorithms.

  12. 40 CFR 55.12 - Consistency updates.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 6 2013-07-01 2013-07-01 false Consistency updates. 55.12 Section 55.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) OUTER CONTINENTAL SHELF AIR REGULATIONS § 55.12 Consistency updates. (a) The Administrator will update this part as necessary to maintain...

  13. Fast Updating National Geo-Spatial Databases with High Resolution Imagery: China's Methodology and Experience

    NASA Astrophysics Data System (ADS)

    Chen, J.; Wang, D.; Zhao, R. L.; Zhang, H.; Liao, A.; Jiu, J.

    2014-04-01

    Geospatial databases are irreplaceable national treasure of immense importance. Their up-to-dateness referring to its consistency with respect to the real world plays a critical role in its value and applications. The continuous updating of map databases at 1:50,000 scales is a massive and difficult task for larger countries of the size of more than several million's kilometer squares. This paper presents the research and technological development to support the national map updating at 1:50,000 scales in China, including the development of updating models and methods, production tools and systems for large-scale and rapid updating, as well as the design and implementation of the continuous updating workflow. The use of many data sources and the integration of these data to form a high accuracy, quality checked product were required. It had in turn required up to date techniques of image matching, semantic integration, generalization, data base management and conflict resolution. Design and develop specific software tools and packages to support the large-scale updating production with high resolution imagery and large-scale data generalization, such as map generalization, GIS-supported change interpretation from imagery, DEM interpolation, image matching-based orthophoto generation, data control at different levels. A national 1:50,000 databases updating strategy and its production workflow were designed, including a full coverage updating pattern characterized by all element topographic data modeling, change detection in all related areas, and whole process data quality controlling, a series of technical production specifications, and a network of updating production units in different geographic places in the country.

  14. The Ribosomal Basis of Diamond-Blackfan Anemia: Mutation and Database Update

    PubMed Central

    Boria, Ilenia; Garelli, Emanuela; Gazda, Hanna T.; Aspesi, Anna; Quarello, Paola; Pavesi, Elisa; Ferrante, Daniela; Meerpohl, Joerg J.; Kartal, Mutlu; Da Costa, Lydie; Proust, Alexis; Leblanc, Thierry; Simansour, Maud; Dahl, Niklas; Fröjmark, Anne-Sophie; Pospisilova, Dagmar; Cmejla, Radek; Beggs, Alan H.; Sheen, Mee R.; Landowski, Michael; Buros, Christopher M.; Clinton, Catherine M.; Dobson, Lori J.; Vlachos, Adrianna; Atsidaftos, Eva; Lipton, Jeffrey M.; Ellis, Steven R.; Ramenghi, Ugo; Dianzani, Irma

    2011-01-01

    Diamond-Blackfan Anemia (DBA) is characterized by a defect of erythroid progenitors and, clinically, by anemia and malformations. DBA exhibits an autosomal dominant pattern of inheritance with incomplete penetrance. Currently nine genes, all encoding ribosomal proteins (RP), have been found mutated in approximately 50% of patients. Experimental evidence supports the hypothesis that DBA is primarily the result of defective ribosome synthesis. By means of a large collaboration among six centers, we report here a mutation update that includes nine genes and 220 distinct mutations, 56 of which are new. The DBA Mutation Database now includes data from 355 patients. Of those where inheritance has been examined, 125 patients carry a de novo mutation and 72 an inherited mutation. Mutagenesis may be ascribed to slippage in 65.5% of indels, whereas CpG dinucleotides are involved in 23% of transitions. Using bioinformatic tools we show that gene conversion mechanism is not common in RP genes mutagenesis, notwithstanding the abundance of RP pseudogenes. Genotype–phenotype analysis reveals that malformations are more frequently associated with mutations in RPL5 and RPL11 than in the other genes. All currently reported DBA mutations together with their functional and clinical data are included in the DBA Mutation Database. PMID:20960466

  15. Relapsing Polychondritis: an Update on Pathogenesis, Clinical Features, Diagnostic Tools, and Therapeutic Perspectives.

    PubMed

    Vitale, Antonio; Sota, Jurgen; Rigante, Donato; Lopalco, Giuseppe; Molinaro, Francesco; Messina, Mario; Iannone, Florenzo; Cantarini, Luca

    2016-01-01

    Relapsing polychondritis is a rare multisystemic disease widely accepted as a complex autoimmune disorder affecting proteoglycan-rich structures and cartilaginous tissues, especially the auricular pinna, cartilage of the nose, tracheobronchial tree, eyes, and heart's connective components. The clinical spectrum may vary from intermittent inflammatory episodes leading to unesthetic structural deformities to life-threatening cardiopulmonary manifestations, such as airway collapse and valvular regurgitation. The frequent association with other rheumatologic and hematologic disorders has been extensively reported over time, contributing to define its complexity at a diagnostic and also therapeutic level. Diagnosis of relapsing polychondritis is mainly based on clinical clues, while laboratory data have only a supportive contribution. Conversely, radiology is showing a relevant role in estimating the rate of systemic involvement as well as disease activity. The present review is aimed at providing an update on scientific data reported during the last 3 years about relapsing polychondritis in terms of pathogenesis, clinical features, diagnosis, and new treatment options. PMID:26711694

  16. Frequent Users of Pornography. A Population Based Epidemiological Study of Swedish Male Adolescents

    ERIC Educational Resources Information Center

    Svedin, Carl Goran; Akerman, Ingrid; Priebe, Gisela

    2011-01-01

    Frequent use of pornography has not been sufficiently studied before. In a Swedish survey 2015 male students aged 18 years participated. A group of frequent users of pornography (N = 200, 10.5%) were studied with respect to background and psychosocial correlates. The frequent users had a more positive attitude to pornography, were more often…

  17. Standards update -- 1995

    SciTech Connect

    Mason, J.D.

    1995-12-31

    What a year this has been! Not since 1986, when SGML was being finished, has there been so much activity in the SGML world. In ISO, there are new standards being completed and old ones (some of which are not really all that old) being revised. As you`ll be hearing, there is lots of SGML activity in the applications world--particularly on the Internet--and that`s causing other kinds of standards activity. WG8 divides its work into five ``Rapporteur Groups`` (or ``RGs``) for DSSSL, Font Description and Interchange, SGML, SPDL, and Hypermedia Languages. Since interest is in DSSSL, SGML, and Hypermedia Languages, the author only mentions that the other groups have been active, too. The Fronts group has been doing amendments to its standards, ISO/IEC 9541 and ISO/IEC 10036. The Fronts groups has been active in providing support for ISO/IEC 10646, the massive character coding standard that has drawn a lot of attention in the SGML world. The SPDL group has at long last finished its standard, the Standard Page Description Language (ISO/IEC 10180) and is about to publish it. More detailed discussions are given for activity in SGML, DSSSL, and Hypermedia Languages.

  18. PACE Status Update

    SciTech Connect

    M., Zimring,; Hoffman, I.; Fuller, M.

    2010-08-11

    The Federal Housing Finance Agency (FHFA) regulates Fannie Mae, Freddie Mac, and the 12 Federal Home Loan Banks (the government-sponsored enterprises - GSEs). On July 6, 2010, FHFA and the Office of the Comptroller of the Currency (OCC) concluded that Property Assessed Clean Energy (PACE) programs 'present significant safety and soundness concerns' to the housing finance industry. This statement came after a year of discussions with state and federal agencies in which PACE, a novel mechanism for financing energy efficiency and renewable energy improvements, has gone from receiving support from the White House, canonization as one of Scientific American's 'World Changing Ideas' and legislative adoption in 24 states to questionable relevance, at least in the residential sector. Whether PACE resumes its expansion as an innovative tool for financing energy efficiency and clean generation depends on outcomes in each of the three branches of government - discussions on a PACE pilot phase among federal agencies, litigation in federal court, and legislation in Congress - all highly uncertain. This policy brief addresses the practical impacts of these possible outcomes on existing and emerging PACE programs across the United States and potential paths forward.

  19. Heidrun concrete TLP: Update

    SciTech Connect

    Munkejord, T.

    1995-10-01

    This paper gives a summary of the Heidrun substructure including tethers and foundations. The focus will although be on the concrete substructure. The Heidrun Field is located in 345 m water depth in the northern part of the Haltenbanken area, approximately 100N miles from the west coast of mid-Norway. The field is developed by means of a concrete Tension Leg Platform (TLP) by Conoco Norway Inc. The TLP will be moored by 16 steel tethers, arranged in groups of four per corner, which secure the substructure (hull) to the concrete foundations. A general view of the TLP is shown. The Heidrun TLP will be the northern most located platform in the North Sea when installed at Haltenbanken in 1995. Norwegian Contractors a.s (NC) is undertaking the Engineering, Procurement, Construction and Installation (EPCI) contract for the Heidrun TLP substructure. This comprises the complete delivery of the hull with two module support beams (MSB), including all mechanical outfitting. Furthermore, NC will perform all marine operations related to the substructure. For the concrete foundations NC has performed the detailed engineering work and has been responsible for the two to field and installation of the foundations.

  20. SABER instrument design update

    NASA Astrophysics Data System (ADS)

    Esplin, Roy W.; Zollinger, Lorin; Batty, J. Clair; Folkman, Steve; Roosta, Mehrdad; Tansock, Joseph J.; Jensen, Mark; Stauder, John; Miller, Jim; Vanek, Michael; Robinson, Don

    1995-09-01

    This paper describes the design of a 10-channel infrared (1.27 to 16.9 micrometers ) radiometer instrument known as SABER (sounding of the atmosphere using broadband emission radiometry) that will measure earth-limb emissions from the TIMED (thermosphere- ionosphere-mesosphere energetics and dynamics) satellite. The instrument telescope, designed to reject stray light from the earth and the atmosphere, is an on-axis Cassegrain design with a clam shell reimager and a one-axis scan mirror. The telescope is cooled below 210 K by a dedicated radiator. The focal plane assembly (consisting of a filter array, a detector array, a Lyot stop, and a window) is cooled to 75 K by a miniature cryogenic refrigerator. The conductive heat load on the refrigerator is minimized by a Kevlar support system that thermally isolates the focal plane assembly from the telescope. Kevlar is also used to thermally isolate the telescope from the spacecraft. Instrument responsivity drifts due to changes in telescope and focal plane temperatures as well as other causes are neutralized by an in-flight calibration system. The detector array consists of discrete HgCdTe, InSb, and InGaAs detectors. Two InGaAs detectors are a new long wavelength type, made by EG&G, that have a long wavelength cutoff of 2.33 micrometers at 77 K.

  1. Updates to the High-Redshift Supernovae in the SCP Union Compilation

    NASA Astrophysics Data System (ADS)

    Rubin, David; Aldering, G. S.; Amanullah, R.; Barbary, K. H.; Bruce, A.; Dawson, K. S.; Doi, M.; Fakhouri, H.; Fruchter, A. S.; Goobar, A.; Huang, X.; Ihara, Y.; Kim, A. G.; Kowalski, M.; Krechmer, E.; Lidman, C.; Linder, E.; Meyers, J.; Morokuma, T.; Nordin, J.; Perlmutter, S.; Rykoff, E. S.; Saunders, C.; Spadafora, A. L.; Suzuki, N.; Takanashi, N.; Yasuda, N.; Cosmology Project, Supernova

    2013-01-01

    Building on the work presented in Amanullah et al. (ApJ, 2010) and Suzuki et al. (ApJ, 2012), adding new z > 1 supernovae discovered in ground-based work and a new analysis of existing HST SNe, we present an updated high-redshift dataset. We update the SCP Union compilation with this and other recent datasets and present updated cosmological fits. This work has been supported by the Office of Science, U.S. Department of Energy (through contract DE-AC02-05CH11231), and in part by NASA through grants associated with HST-GO-10496.

  2. Update on prenatal care.

    PubMed

    Zolotor, Adam J; Carlough, Martha C

    2014-02-01

    Many elements of routine prenatal care are based on tradition and lack a firm evidence base; however, some elements are supported by more rigorous studies. Correct dating of the pregnancy is critical to prevent unnecessary inductions and to allow for accurate treatment of preterm labor. Physicians should recommend folic acid supplementation to all women as early as possible, preferably before conception, to reduce the risk of neural tube defects. Administration of Rho(D) immune globulin markedly decreases the risk of alloimmunization in an RhD-negative woman carrying an RhD-positive fetus. Screening and treatment for iron deficiency anemia can reduce the risks of preterm labor, intrauterine growth retardation, and perinatal depression. Testing for aneuploidy and neural tube defects should be offered to all pregnant women with a discussion of the risks and benefits. Specific genetic testing should be based on the family histories of the patient and her partner. Physicians should recommend that pregnant women receive a vaccination for influenza, be screened for asymptomatic bacteriuria, and be tested for sexually transmitted infections. Testing for group B streptococcus should be performed between 35 and 37 weeks' gestation. If test results are positive or the patient has a history of group B streptococcus bacteriuria during pregnancy, intrapartum antibiotic prophylaxis should be administered to reduce the risk of infection in the infant. Intramuscular or vaginal progesterone should be considered in women with a history of spontaneous preterm labor, preterm premature rupture of membranes, or shortened cervical length (less than 2.5 cm). Screening for diabetes should be offered using a universal or a risk-based approach. Women at risk of preeclampsia should be offered low-dose aspirin prophylaxis, as well as calcium supplementation if dietary calcium intake is low. Induction of labor may be considered between 41 and 42 weeks' gestation. PMID:24506122

  3. Update on Autoimmune Hepatitis

    PubMed Central

    Liberal, Rodrigo; Vergani, Diego; Mieli-Vergani, Giorgina

    2015-01-01

    Autoimmune hepatitis (AIH), a liver disorder affecting both children and adults, is characterized by inflammatory liver histology, elevated transaminase levels, circulating nonorganspecific autoantibodies, and increased levels of immunoglobulin G, in the absence of a known etiology. Two types of AIH are recognized according to seropositivity: smooth muscle antibody and/or antinuclear antibody define AIH type 1 and antibodies to liver-kidney microsome type 1 and/or liver cytosol type 1 define AIH type 2. AIH type 1 affects both adults and children, while AIH type 2 is mainly a paediatric disease, though it does occasionally affects young adults. AIH should be considered during the diagnostic workup of any patient with increased liver enzyme levels. AIH is exquisitely responsive to immunosuppressive treatment with prednisolone with or without azathioprine, with symptom free long-term survival for the majority of patients. For those who do not respond to standard treatment, or who are difficult-to-treat, mycophenolate mofetil and, in the absence of a response, calcineurin inhibitors should be tried in addition to steroids. The pathogenesis of AIH is not fully understood, although there is mounting evidence that genetic susceptibility, molecular mimicry and impaired immunoregulatory networks contribute to the initiation and perpetuation of the autoimmune attack. Liver damage is thought to be mediated primarily by CD4 T-cells, although recent studies support the involvement of diverse populations, including Th17 cells. A deeper understanding of the pathogenesis of AIH is likely to contribute to the development of novel treatments, such as the adoptive transfer of autologous expanded antigenspecific regulatory T-cells, which ultimately aim at restoring tolerance to liver-derived antigens. PMID:26357634

  4. Frequent Urination

    MedlinePlus

    ... Schueler, MD How it Works Testimonials FAQ for Consumers FAQ for Physicians News Advertising Terms of Use Contact Us Site Map How it Works When people are sick, they must make critical decisions about when and where they should receive healthcare. ...

  5. Update on Allergy Immunotherapy

    PubMed Central

    2005-01-01

    This article summarizes and provides commentary regarding guidelines on the administration of immunotherapy (IT) for allergic airway disease. Recent investigations have provided important insights into the immunologic mechanism of IT and the prominent role of interleukin-10-producing regulatory T lymphocytes. The most important aspect of successful IT is the administration of an appropriate dose of an extract containing a sufficient concentration of the relevant allergen. This is largely possible now only with standardized extracts. When the major allergen content of successful IT extracts was quantified, efficacy was demonstrated across a surprisingly narrow concentration range (approximately 5-24 μg per injection), irrespective of the extract. This presumably reflects the concentration of an antigen that drives an immune response toward tolerance. It may be predicted that as major allergen content is quantified in currently nonstandardized extracts, effective IT will also be achieved by administering a dose in this range, in contrast to current practices involving fairly arbitrary dosing decisions. With the availability of nonsedating antihistamines, intranasal corticosteroids, and the leukotriene modifiers, inadequate pharmacologic response or intolerable side effects are less commonly the major indications for starting IT for allergic rhinitis (AR). However, with the recognition that a relatively short course (3-5 years) of IT can provide long-term immunomodulation and clinical benefit, a desire to avoid long-term pharmacotherapy and the associated high costs may be the primary indication for IT in AR cases. While evidence overwhelmingly supports the beneficial influences of IT in asthma cases, the positioning of IT for this disorder is not established. The observed prevention of asthma in children who have AR is intriguing, but further studies are required to assess the extent to which the prevalence and severity of chronic asthma will be reduced when these

  6. NASA UAS Update

    NASA Technical Reports Server (NTRS)

    Bauer, Jeffrey Ervin; Mulac, Brenda Lynn

    2010-01-01

    Last year may prove to be a pivotal year for the National Aeronautics and Space Administration (NASA) in the Unmanned Aircraft Systems (UAS) arena, especially in relation to routine UAS access to airspace as NASA accepted an invitation to join the UAS Executive Committee (UAS ExCom). The UAS ExCom is a multi-agency, Federal executive-level committee comprised of the Federal Aviation Administration (FAA), Department of Defense (DoD), Department of Homeland Security (DHS), and NASA with the goals to: 1) Coordinate and align efforts between key Federal Government agencies to achieve routine safe federal public UAS operations in the National Airspace System (NAS); 2) Coordinate and prioritize technical, procedural, regulatory, and policy solutions needed to deliver incremental capabilities; 3) Develop a plan to accommodate the larger stakeholder community at the appropriate time; and 4) Resolve conflicts between Federal Government agencies (FAA, DoD, DHS, and NASA), related to the above goals. The committee was formed in recognition of the need of UAS operated by these agencies to access to the National Airspace System (NAS) to support operational, training, development and research requirements. In order to meet that need, technical, procedural, regulatory, and policy solutions are required to deliver incremental capabilities leading to routine access. The formation of the UAS ExCom is significant in that it represents a tangible commitment by FAA senior leadership to address the UAS access challenge. While the focus of the ExCom is government owned and operated UAS, civil UAS operations are bound to benefit by the progress made in achieving routine access for government UAS. As the UAS ExCom was forming, NASA's Aeronautics Research Mission Directorate began to show renewed interest in UAS, particularly in relation to the future state of the air transportation system under the Next Generation Air Transportation System (NextGen). NASA made funding from the American

  7. Source Update Capture in Information Agents

    NASA Technical Reports Server (NTRS)

    Ashish, Naveen; Kulkarni, Deepak; Wang, Yao

    2003-01-01

    In this paper we present strategies for successfully capturing updates at Web sources. Web-based information agents provide integrated access to autonomous Web sources that can get updated. For many information agent applications we are interested in knowing when a Web source to which the application provides access, has been updated. We may also be interested in capturing all the updates at a Web source over a period of time i.e., detecting the updates and, for each update retrieving and storing the new version of data. Previous work on update and change detection by polling does not adequately address this problem. We present strategies for intelligently polling a Web source for efficiently capturing changes at the source.

  8. A Successive Selection Method for finite element model updating

    NASA Astrophysics Data System (ADS)

    Gou, Baiyong; Zhang, Weijie; Lu, Qiuhai; Wang, Bo

    2016-03-01

    Finite Element (FE) model can be updated effectively and efficiently by using the Response Surface Method (RSM). However, it often involves performance trade-offs such as high computational cost for better accuracy or loss of efficiency for lots of design parameter updates. This paper proposes a Successive Selection Method (SSM), which is based on the linear Response Surface (RS) function and orthogonal design. SSM rewrites the linear RS function into a number of linear equations to adjust the Design of Experiment (DOE) after every FE calculation. SSM aims to interpret the implicit information provided by the FE analysis, to locate the Design of Experiment (DOE) points more quickly and accurately, and thereby to alleviate the computational burden. This paper introduces the SSM and its application, describes the solution steps of point selection for DOE in detail, and analyzes SSM's high efficiency and accuracy in the FE model updating. A numerical example of a simply supported beam and a practical example of a vehicle brake disc show that the SSM can provide higher speed and precision in FE model updating for engineering problems than traditional RSM.

  9. A Meteorological Model's Dependence on Radiation Update Frequency

    NASA Technical Reports Server (NTRS)

    Eastman, Joseph L.; Peters-Lidard, Christa; Tao, Wei-Kuo; Kumar, Sujay; Tian, Yudong; Lang, Stephen E.; Zeng, Xiping

    2004-01-01

    Numerical weather models are used to simulate circulations in the atmosphere including clouds and precipitation by applying a set of mathematical equations over a three-dimensional grid. The grid is composed of discrete points at which the meteorological variables are defined. As computing power continues to rise these models are being used at finer grid spacing, but they must still cover a wide range of scales. Some of the physics that must be accounted for in the model cannot be explicitly resolved, and their effects, therefore, must be estimated or "parameterized". Some of these parameterizations are computationally expensive. To alleviate the problem, they are not always updated at the time resolution of the model with the assumption being that the impact will be small. In this study, a coupled land-atmosphere model is used to assess the impact of less frequent updates of the computationally expensive radiation physics for a case on June 6, 2002, that occurred during a field experiment over the central plains known as International H20 Project (IHOP). The model was tested using both the original conditions, which were dry, and with modified conditions wherein moisture was added to the lower part of the atmosphere to produce clouds and precipitation (i.e., a wet case). For each of the conditions (i.e., dry and wet), four set of experiments were conducted wherein the model was run for a period of 24 hours and the radiation fields (including both incoming solar and outgoing longwave) were updated every 1, 3, 10, and 100 time steps. Statistical tests indicated that average quantities of surface variables for both the dry and wet cases were the same for the various update frequencies. However, spatially the results could be quite different especially in the wet case after it began to rain. The near-surface wind field was found to be different most of the time even for the dry case. In the wet case, rain intensities and average vertical profiles of heating associated

  10. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-11-01

    (Post-16 Initiative) Engineering Physics? Many A-level physics students do not go on to study physics. For them physics is a support subject, either just for fun or just for the grade. Where physics is a lead subject some students go on to study physics but many more go on to study engineering. So can we deliberately give some aspects of an A-level course an engineering flavour? Electromagnetism would seem a good place to start. There is a clear `physics' route into this topic, a microscopic forces and fields view of the situation. But do our students really need to look at it this way? All electromagnetic machines are linked magnetic and electric circuits. The design idea is to link these circuits as closely as possible. The electric circuits must be as good as possible, with a high conductivity. The magnetic circuits must be as good as possible, with high permeance. Conductivity depends on area/length. So does permeance. The goodness of an electromagnetic machine (how good it is at its job, which is linking electric and magnetic circuits) scales as the square of its linear dimensions. That means small electromagnetic machines are harder to make, and so the very smallest nanomotors are electrostatic. None of this is new, but many teachers are uncomfortable with it. We are thinking like physicists. Many of our students are not. They deserve us to take the trouble every now and again to encourage them to think a bit differently about a topic, to look at practical ways of discussing design and to give their course an engineering flavour. Philip Britton Coursework in A-level Physics The criteria for the new AS and A-levels have provided the teams developing the specifications with an opportunity to think creatively about how internal assessment is used within post-16 physics courses. Teachers may be concerned that allowing 30% of the marks to be internally assessed will create a burden for them. However, it is possible to look at this in a much more positive light

  11. An Update on AGU Publishing

    NASA Astrophysics Data System (ADS)

    Hilst, Rob; Hanson, Brooks

    2013-07-01

    In the past year, AGU publishing has undergone substantial change, and we realize that this has caused some anxiety and concern among you, our members. As the start of a regular Eos series on issues in scientific publishing in general and AGU's content in particular, we provide here an overview and update of recent developments, with an emphasis on the partnership between AGU and Wiley. Topical entries, for instance on open access, will be published later.

  12. MEMS Stirling Cooler Development Update

    NASA Technical Reports Server (NTRS)

    Moran, Matthew E.; Wesolek, Danielle

    2003-01-01

    This presentation provides an update on the effort to build and test a prototype unit of the patented MEMS Stirling cooler concept. A micro-scale regenerator has been fabricated by Polar Thermal Technologies and is currently being integrated into a Stirling cycle simulator at Johns Hopkins University Applied Physics Laboratory. A discussion of the analysis, design, assembly, and test plans for the prototype will be presented.

  13. Imaging in neuroblastoma: An update

    PubMed Central

    Kembhavi, Seema A; Shah, Sneha; Rangarajan, Venkatesh; Qureshi, Sajid; Popat, Palak; Kurkure, Purna

    2015-01-01

    Neuroblastoma is the third common tumor in children. Imaging plays an important role in the diagnosis, staging, treatment planning, response evaluation and in follow-up of a case of Neuroblastoma. The International Neuroblastoma Risk Group task force has recently introduced an imaging-based staging system and laid down guidelines for uniform reporting of imaging studies. This review is an update on imaging in neuroblastoma, with emphasis on these guidelines. PMID:25969636

  14. WFGD system materials cost update

    SciTech Connect

    Milobowski, M.G.

    1998-12-31

    This paper is an update of the report ``Economic Comparison of Materials of Construction of Wet FGD Absorbers and Internals`` which was presented at the 1991 EPRI/EPA/DOE SO{sub 2} Control symposium. An economic comparison of the materials standardly used for fabrication of wet FGD spray towers will be presented in this paper. Costs for various materials of construction for such absorber components as spray headers, moisture separators, and gas distribution devices will also be addressed,

  15. Update on Banned Substances 2013

    PubMed Central

    Barnes, Kenneth P.; Rainbow, Catherine R.

    2013-01-01

    Context: Doping has been pervasive throughout the history of athletic competitions and has only recently been regulated by organizations such as the World Anti-Doping Agency (WADA), US Anti-Doping Agency (USADA), and the National Collegiate Athletic Association (NCAA). These regulatory bodies were created to preserve fair play and maintain the safety of the participants. Their updated 2013 lists of banned substances and practices include a variety of drugs and practices that could cause harm to an athlete or give one an unfair competitive advantage. Evidence Acquisition: Published websites for the WADA, USADA, and NCAA were investigated. These governing bodies update and publish their lists annually. Results: The WADA, USADA, and NCAA monitor anabolic steroids, hormones, growth factors, β-agonists, hormone and metabolic modulators, masking agents, street drugs, manipulation of blood and blood components, chemical and physical manipulation, gene doping, stimulants, narcotics, glucocorticosteroids, and β-blockers. Some substances may be used by athletes but require formal exemption. The WADA has also recently created a category of nonapproved substances that have yet to be identified to curb athletes from experimenting with new doping agents. Conclusion: The lists of banned substances and practices per the WADA, USADA, and NCAA are in place to ensure the integrity of sports and maintain safe competition. Health care providers who work with athletes under the jurisdiction of these organizations should review updated lists of banned substances when prescribing medications. PMID:24427415

  16. Deductive updating is not Bayesian.

    PubMed

    Markovits, Henry; Brisson, Janie; de Chantal, Pier-Luc

    2015-07-01

    One of the major debates concerning the nature of inferential reasoning is between counterexample-based theories such as mental model theory and probabilistic theories. This study looks at conclusion updating after the addition of statistical information to examine the hypothesis that deductive reasoning cannot be explained by probabilistic inferences. In Study 1, participants were given an initial "If P then Q rule" for a phenomenon on a recently discovered planet, told that "Q was true," and asked to make a judgment of either deductive validity or probabilistic likelihood of the putative conclusion that "P is true." They were then told the results of 1,000 observations. In the low-probability problem, 950 times P was false and Q was true, whereas 50 times P was true and Q was true. In the high-probability problem, these proportions were inverted. On the low-probability problem, probabilistic ratings and judgments of logical validity decreased. However, on the high-probability problem, probabilistic ratings remained high whereas judgments of logical validity significantly decreased. Confidence ratings were consistent with this different pattern for probabilistic and for deductive inferences. Study 2 replicated this result with another form of inference, "If P then Q. P is false." These results show that deductive updating is not explicable by Bayesian updating. PMID:25603167

  17. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-09-01

    Institute of Physics post-16 initiative, shaping the future Physics education based in IT - sorry ICT! Which, of course, makes for a nifty headline, but as is so often the case with neat slogans, little else. Two formative questions: What, in another decade, will the government of the day call `What you lot should be doing with computers'? and What, of the many things that currently exercise our intellects, will there be anything special to say about in a decade, concerning the use of computers in the teaching of physics? Advancing Physics represents some attempts to come to grips with the second of the two questions above. The first is left to a higher wisdom. In thinking about learning, what can we do with the huge processing power, increasingly available in smaller and less obtrusive packages? What will we do that helps people learn physics, both tomorrow and in 2009? Here are a few suggestions based on development work so far. Wide, reliable and shared access to well ordered learning resources. We have created a CD-ROM, with versions for both student and teacher, that provides a wide range of resources. These do not teach, but do provide. A commitment to allowing a course to evolve and adapt. Electronic publication puts the costs into origination, and not into publication and distribution. A website allows for the community of users to contribute. E-mail networks support individuals and propagate good practice. You can create and explore your own microworlds. The interactive nature of models, and the crafted relationships between the models and the natural world give an insight into the creative imaginary worlds of the physicist. The unreasonable, but pleasurable, success of mathematics in describing the natural world can come to the fore. Measurements that were not possible before are now possible. What was previously indirect, and inaccessible, now becomes a direct measurement, making relationships transparent in new and fruitful ways. The dichotomy between

  18. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-03-01

    characteristics of particular functions. Modelling tools allow teachers or students to build models or more simply to create animations to demonstrate the properties of mathematical entities such as vectors. Graphical calculators mean that all students can have cheap access to such tools and it may be that some of the analytical mathematical tools we hold so dear are obsolete. Other issues are discussed in the booklet and were aired at the ASE conference: the situation in HE, the approach to mathematics taken by the Salters Horners approach, ways to introduce special functions such as exponentials, ways of thinking about the relationships between variables as expressed in equations. Many practical suggestions are made in the booklet about how we can help and support students and, most importantly, how we can communicate to them some of the beauty and pleasure of Physics in Mathematical Mood. Simon Carson A perspective on apparatus The effective deployment of apparatus is one technique available in physics that does not exist in some other areas of teaching. We should capitalize on this. Apparatus is a tool that can be used to enable thinking and learning. There are a number of purposes to be served by the effective use of apparatus. It is no more likely that apparatus will `teach' any more than nature `teaches' physics in the first place. Discussion and the creative interpretation of observation are both necessary to the sense-making process. Apparatus must be chosen with these opportunities in mind. In a demonstration we are trying to persuade students that the world behaves in a particular way. An attempt is being made to persuade students that a particular conception of the world is worth considering and that this conception is a fruitful and truthful picture of the world. Apparatus chosen for this purpose must have clear links between what is to be measured and the representations of that measurement. The art of demonstration is very much like a magician's show, in that it

  19. Assessment of a method to detect signals for updating systematic reviews

    PubMed Central

    2014-01-01

    was Kappa = 0.74. Conclusions These results provide some support for the validity of a surveillance system for detecting signals indicating when a systematic review needs updating. PMID:24529068

  20. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-03-01

    characteristics of particular functions. Modelling tools allow teachers or students to build models or more simply to create animations to demonstrate the properties of mathematical entities such as vectors. Graphical calculators mean that all students can have cheap access to such tools and it may be that some of the analytical mathematical tools we hold so dear are obsolete. Other issues are discussed in the booklet and were aired at the ASE conference: the situation in HE, the approach to mathematics taken by the Salters Horners approach, ways to introduce special functions such as exponentials, ways of thinking about the relationships between variables as expressed in equations. Many practical suggestions are made in the booklet about how we can help and support students and, most importantly, how we can communicate to them some of the beauty and pleasure of Physics in Mathematical Mood. Simon Carson A perspective on apparatus The effective deployment of apparatus is one technique available in physics that does not exist in some other areas of teaching. We should capitalize on this. Apparatus is a tool that can be used to enable thinking and learning. There are a number of purposes to be served by the effective use of apparatus. It is no more likely that apparatus will `teach' any more than nature `teaches' physics in the first place. Discussion and the creative interpretation of observation are both necessary to the sense-making process. Apparatus must be chosen with these opportunities in mind. In a demonstration we are trying to persuade students that the world behaves in a particular way. An attempt is being made to persuade students that a particular conception of the world is worth considering and that this conception is a fruitful and truthful picture of the world. Apparatus chosen for this purpose must have clear links between what is to be measured and the representations of that measurement. The art of demonstration is very much like a magician's show, in that it

  1. Carriage of Multidrug Resistant Bacteria on Frequently Contacted Surfaces and Hands of Health Care Workers

    PubMed Central

    Visalachy, Sowndarya; Kopula, Sridharan Sathyamoorthy; Sekar, Uma

    2016-01-01

    Introduction Maximal contact between the patients and Health Care Workers (HCWs) happens in the Intensive Care Units (ICU). Control of nosocomial infections requires compliance with hand hygiene and contamination free surfaces. Aim To determine the colonization of potential pathogens in the hands of HCWs and frequent contacted environmental surfaces. Materials and Methods A cross sectional study was conducted between September 2012 and May 2013 at Sri Ramachandra Medical College and Hospital. A total of 327 samples were collected using Glove juice technique from hands and swabs from frequently contacted surfaces. A sum of 157 samples were collected by glove juice technique from the hands of HCWs which included Consultants (20), Internees (3), Residents (10), Staff nurse (102) and support staff (22). A total of 170 samples were collected through swabbing which included frequently touched surfaces of apron and dress (140 which included 10 consultants, 3 internees, 9 Residents, 101 Staff nurse and 17 support staff), 9 door handle, 4 key board, 12 tap handles and 5 monitors. The samples were inoculated into Blood agar, Chocolate agar and Mac-Conkey agar plates and incubated at 370C aerobically. The plates showing growth were further processed to identify the organisms by Gram staining and biochemical reactions. Antibiotic susceptibility testing was done for the isolates by Kirby-baur disc diffusion method as per CLSI guidelines. Results Out of the 157 hand sampling done by glove juice method 67(42.7%) of them showed growth and 90(57.3%) showed no growth. The potential pathogens grown were 13 (8.3%), consisting of Methicillin Sensitive Staphylococcus aureus (MSSA) 6(3.8%), Methicillin Resistant Staphylococcus aureus (MRSA) 2(1.3%), Pseudomonas spp 4(2.6%) and Acenitobacter spp 1 (0.6%). The MRSA was seen in Consultant 1(5%; n=20) and Staff nurse 1(0.9%; n= 102). Among the 140 sampling from the dress of HCWs growth was observed in 69(49.3%) and growth was absent in 71

  2. The universal tree of life: an update

    PubMed Central

    Forterre, Patrick

    2015-01-01

    Biologists used to draw schematic “universal” trees of life as metaphors illustrating the history of life. It is indeed a priori possible to construct an organismal tree connecting the three major domains of ribosome encoding organisms: Archaea, Bacteria and Eukarya, since they originated by cell division from LUCA. Several universal trees based on ribosomal RNA sequence comparisons proposed at the end of the last century are still widely used, although some of their main features have been challenged by subsequent analyses. Several authors have proposed to replace the traditional universal tree with a ring of life, whereas others have proposed more recently to include viruses as new domains. These proposals are misleading, suggesting that endosymbiosis can modify the shape of a tree or that viruses originated from the last universal common ancestor (LUCA). I propose here an updated version of Woese’s universal tree that includes several rootings for each domain and internal branching within domains that are supported by recent phylogenomic analyses of domain specific proteins. The tree is rooted between Bacteria and Arkarya, a new name proposed for the clade grouping Archaea and Eukarya. A consensus version, in which each of the three domains is unrooted, and a version in which eukaryotes emerged within archaea are also presented. This last scenario assumes the transformation of a modern domain into another, a controversial evolutionary pathway. Viruses are not indicated in these trees but are intrinsically present because they infect the tree from its roots to its leaves. Finally, I present a detailed tree of the domain Archaea, proposing the sub-phylum neo-Euryarchaeota for the monophyletic group of euryarchaeota containing DNA gyrase. These trees, that will be easily updated as new data become available, could be useful to discuss controversial scenarios regarding early life evolution. PMID:26257711

  3. The universal tree of life: an update.

    PubMed

    Forterre, Patrick

    2015-01-01

    Biologists used to draw schematic "universal" trees of life as metaphors illustrating the history of life. It is indeed a priori possible to construct an organismal tree connecting the three major domains of ribosome encoding organisms: Archaea, Bacteria and Eukarya, since they originated by cell division from LUCA. Several universal trees based on ribosomal RNA sequence comparisons proposed at the end of the last century are still widely used, although some of their main features have been challenged by subsequent analyses. Several authors have proposed to replace the traditional universal tree with a ring of life, whereas others have proposed more recently to include viruses as new domains. These proposals are misleading, suggesting that endosymbiosis can modify the shape of a tree or that viruses originated from the last universal common ancestor (LUCA). I propose here an updated version of Woese's universal tree that includes several rootings for each domain and internal branching within domains that are supported by recent phylogenomic analyses of domain specific proteins. The tree is rooted between Bacteria and Arkarya, a new name proposed for the clade grouping Archaea and Eukarya. A consensus version, in which each of the three domains is unrooted, and a version in which eukaryotes emerged within archaea are also presented. This last scenario assumes the transformation of a modern domain into another, a controversial evolutionary pathway. Viruses are not indicated in these trees but are intrinsically present because they infect the tree from its roots to its leaves. Finally, I present a detailed tree of the domain Archaea, proposing the sub-phylum neo-Euryarchaeota for the monophyletic group of euryarchaeota containing DNA gyrase. These trees, that will be easily updated as new data become available, could be useful to discuss controversial scenarios regarding early life evolution. PMID:26257711

  4. Predictors of Frequent Recourse to Health Professionals by People With Severe Mental Disorders

    PubMed Central

    Fleury, Marie-Josée; Grenier, Guy; Bamvita, Jean-Marie

    2015-01-01

    Objective: Based on Andersen’s behavioural model, our study sought to determine predictors and blocks of factors that could explain why people with severe mental disorders (SMDs) more often seek the services of health professionals. Methods: This longitudinal study involved 292 users with SMDs located in Le Sud-Ouest, the southwest borough of Montreal. Data were collected from participants’ medical records and through 7 questionnaires. Using Andersen’s Behavioral Model of Health Services Use, independent variables were divided into 3 classes—predisposing factors, enabling factors, and need factors—and were introduced in this order in a hierarchical logistic model. Results: Among 292 users, 110 (37.7%) were frequent users who consulted about one health professional every 3 days. Participants who were more likely to call on health professionals were single and older, depended on welfare as their main source of income, lived in supervised housing, suffered from schizophrenia, schizophrenia spectrum disorders, and adjustment disorders, and, marginally, exhibited multiple mental disorders. Conclusion: Mental health services could promote strategies to overcome the reluctance of younger people to seek professional services. Professionals should pay close attention to subsidiary conditions, such as adjustment disorders, from which people with SMDs may suffer. Interventions to improve the socioeconomic condition of unemployed people with SMDs may help to reduce health care service use among that clientele. Programs such as supported employment should be tailored and enhanced for people receiving welfare to decrease stigmatization and improve job market integration. PMID:25886658

  5. Application of Gap-Constraints Given Sequential Frequent Pattern Mining for Protein Function Prediction

    PubMed Central

    Park, Hyeon Ah; Kim, Taewook; Li, Meijing; Shon, Ho Sun; Park, Jeong Seok; Ryu, Keun Ho

    2015-01-01

    Objectives Predicting protein function from the protein–protein interaction network is challenging due to its complexity and huge scale of protein interaction process along with inconsistent pattern. Previously proposed methods such as neighbor counting, network analysis, and graph pattern mining has predicted functions by calculating the rules and probability of patterns inside network. Although these methods have shown good prediction, difficulty still exists in searching several functions that are exceptional from simple rules and patterns as a result of not considering the inconsistent aspect of the interaction network. Methods In this article, we propose a novel approach using the sequential pattern mining method with gap-constraints. To overcome the inconsistency problem, we suggest frequent functional patterns to include every possible functional sequence—including patterns for which search is limited by the structure of connection or level of neighborhood layer. We also constructed a tree-graph with the most crucial interaction information of the target protein, and generated candidate sets to assign by sequential pattern mining allowing gaps. Results The parameters of pattern length, maximum gaps, and minimum support were given to find the best setting for the most accurate prediction. The highest accuracy rate was 0.972, which showed better results than the simple neighbor counting approach and link-based approach. Conclusion The results comparison with other approaches has confirmed that the proposed approach could reach more function candidates that previous methods could not obtain. PMID:25938021

  6. Comparative effectiveness and cost-effectiveness analyses frequently agree on value.

    PubMed

    Glick, Henry A; McElligott, Sean; Pauly, Mark V; Willke, Richard J; Bergquist, Henry; Doshi, Jalpa; Fleisher, Lee A; Kinosian, Bruce; Perfetto, Eleanor; Polsky, Daniel E; Schwartz, J Sanford

    2015-05-01

    The Patient-Centered Outcomes Research Institute, known as PCORI, was established by Congress as part of the Affordable Care Act (ACA) to promote evidence-based treatment. Provisions of the ACA prohibit the use of a cost-effectiveness analysis threshold and quality-adjusted life-years (QALYs) in PCORI comparative effectiveness studies, which has been understood as a prohibition on support for PCORI's conducting conventional cost-effectiveness analyses. This constraint complicates evidence-based choices where incremental improvements in outcomes are achieved at increased costs of care. How frequently this limitation inhibits efficient cost containment, also a goal of the ACA, depends on how often more effective treatment is not cost-effective relative to less effective treatment. We examined the largest database of studies of comparisons of effectiveness and cost-effectiveness to see how often there is disagreement between the more effective treatment and the cost-effective treatment, for various thresholds that may define good value. We found that under the benchmark assumption, disagreement between the two types of analyses occurs in 19 percent of cases. Disagreement is more likely to occur if a treatment intervention is musculoskeletal and less likely to occur if it is surgical or involves secondary prevention, or if the study was funded by a pharmaceutical company. PMID:25941282

  7. Disturbed dreaming and sleep quality: altered sleep architecture in subjects with frequent nightmares.

    PubMed

    Simor, Péter; Horváth, Klára; Gombos, Ferenc; Takács, Krisztina P; Bódizs, Róbert

    2012-12-01

    Nightmares are intense, emotionally negative mental experiences that usually occur during late-night sleep and result in abrupt awakenings. Questionnaire-based studies have shown that nightmares are related to impaired sleep quality; however, the polysomnographic profile of nightmare subjects has been only scarcely investigated. We investigated the sleep architecture of 17 individuals with frequent nightmares and 23 control subjects based on polysomnographic recordings of a second night spent in the laboratory after an adaptation night. Nightmare subjects in comparison with control subjects were characterized by impaired sleep architecture, as reflected by reduced sleep efficiency, increased wakefulness, a reduced amount of slow wave sleep, and increased nocturnal awakenings, especially from Stage 2 sleep. While these differences were independent of the effects of waking psychopathology, nightmare subjects also exhibited longer durations of REM sleep that was mediated by heightened negative affect. Our results support that nightmares are related to altered sleep architecture, showing impaired sleep continuity and emotion-related increase in REM propensity. PMID:22526731

  8. Frequent users of pornography. A population based epidemiological study of Swedish male adolescents.

    PubMed

    Svedin, Carl Göran; Akerman, Ingrid; Priebe, Gisela

    2011-08-01

    Frequent use of pornography has not been sufficiently studied before. In a Swedish survey 2015 male students aged 18 years participated. A group of frequent users of pornography (N = 200, 10.5%) were studied with respect to background and psychosocial correlates. The frequent users had a more positive attitude to pornography, were more often "turned on" viewing pornography and viewed more often advanced forms of pornography. Frequent use was also associated with many problem behaviours. A multiple logistic regression analysis showed that frequent users of pornography were more likely to be living in a large city, consuming alcohol more often, having greater sexual desire and had more often sold sex than other boys of the same age. High frequent viewing of pornography may be seen as a problematic behaviour that needs more attention from both parents and teachers and also to be addressed in clinical interviews. PMID:20888038

  9. Performance of a new wind updating system for a prognostic meteorological model in the environs of Mexico City

    SciTech Connect

    Williams, M.D.

    1993-12-31

    Los Alamos National Laboratory and Institute Mexicano del Petroleo are completely a joint study of options for improving air quality in Mexico City. The US Department of Energy supported the efforts of the Los Alamos investigators, while PEMEX supported the efforts of the Mexican researchers. One of the first steps in the process was to develop an understanding of the existing air quality situation. In this context we have modified a three-dimensional, prognostic, higher order turbulence model for atmospheric circulation (HOTMAC) to treat domains which include an urbanized area. This sophisticated meteorological model is required because of the complexity of the terrain and the relative paucity of meteorological data. Mexico City lies at an elevation of approximately 7500 feet above sea level in a ``U`` shaped basin which opens to the north. The city occupies a major part of the southwest portion of the basin. Upper level winds are provided by rawinsondes at the airport, while low-level winds are measured at several sites within the city. Many of the sites have obstructed upwind fetches for a variety of directions. During the wintertime when the worst air quality episodes occur, the winds are frequently light, and out of the northeast at lower levels, while above 1000 meters above the surface they are usually from the southwest. This means the winds are light within the city, but significant slope winds develop which influence the behavior of the pollutants. Frequently, the winds in the basin change as a seabreeze penetrates the basin from the northeast. The seabreeze produces a much different wind regime after its arrival in the late afternoon or early evening. This makes it important to update the winds in a realistic fashion.

  10. The inter-contact interval: a new measure to define frequent attenders in primary care

    PubMed Central

    2013-01-01

    Background Frequent attenders receive much attention in primary care research. Defining frequent attendance is crucial for an adequate view on this group of demanding patients. We aimed to develop a purely contact-based definition of “frequent attendance” and to apply it to real patients. Methods From electronic records of 123 general practices in Germany, patients’ inter-contact intervals (ICI) between two consecutive doctor-patient-contacts were calculated in this retrospective observational study. ICI less than 7 days were labelled “frequent attendance”, patients with 60% or more of such intervals “frequent attenders (new view)”. In contrast, patients having at least 24 contacts per calendar year were considered “frequent attenders (traditional view)”. Both groups were analysed in their diseases and demands, using multiple logistic regression. Results A total of 177,057 patients with at least 3 ICI in 1996 until 2006 yielded 4,408,033 ICI. One third were “short” ICI (less than 7 days), resulting in 19,759 (11.2%) frequent attenders (new). In contrast, 22,921 (12.9%) patients were frequent attenders (traditional). Compared to non-frequent attenders, frequent attenders (new) were more likely to have pneumonia (OR 1.66), stroke (OR 1.49), dementia (OR 1.46), or severe substance abuse (OR 1.44), also to need home visits or emergency attention. Frequent attenders (traditional) were more likely to have dementia (OR 2.76) or stroke (OR 2.06), and by far to need home visits (OR 5.43; all p < 0.001). Conclusions A new measure, the interval in days of two consecutive face-to-face contacts (ICI), widens our perspective on frequent attenders in general practice. In many cases, their consultation behaviour and need for medical services seem to follow “disease logic”. PMID:24152427

  11. Communication Concepts Related to Perceived Organizational Support.

    ERIC Educational Resources Information Center

    Allen, Myria Watkins

    1995-01-01

    Finds that employee perceptions regarding top management's general expressions of support for employees, formal positive feedback directed towards individuals, and decision-making input were strongly related to perceived organizational support; employees talked more frequently about their organization's support of its employees with coworkers than…

  12. LSAT[R] Scores of Economics Majors: The 2008-9 Class Update

    ERIC Educational Resources Information Center

    Nieswiadomy, Michael

    2010-01-01

    Using 1994-95 and 2002-3 data, the author (1998, 2006) has found that economics majors scored well on the LSAT[R]. These results are frequently posted on university Web sites by economics (and other) departments. The author, who updates the previous studies by using current 2007-8 law school applicants for the 2008-9 class of students entering law…

  13. Identifying Frequent Users of an Urban Emergency Medical Service Using Descriptive Statistics and Regression Analyses

    PubMed Central

    Norman, Chenelle; Mello, Michael; Choi, Bryan

    2016-01-01

    This retrospective cohort study provides a descriptive analysis of a population that frequently uses an urban emergency medical service (EMS) and identifies factors that contribute to use among all frequent users. For purposes of this study we divided frequent users into the following groups: low- frequent users (4 EMS transports in 2012), medium-frequent users (5 to 6 EMS transports in 2012), high-frequent users (7 to 10 EMS transports in 2012) and super-frequent users (11 or more EMS transports in 2012). Overall, we identified 539 individuals as frequent users. For all groups of EMS frequent users (i.e. low, medium, high and super) one or more hospital admissions, receiving a referral for follow-up care upon discharge, and having no insurance were found to be statistically significant with frequent EMS use (P<0.05). Within the diagnostic categories, 41.61% of super-frequent users had a diagnosis of “primarily substance abuse/misuse” and among low-frequent users a majority, 53.33%, were identified as having a “reoccurring (medical) diagnosis.” Lastly, relative risk ratios for the highest group of users, super-frequent users, were 3.34 (95% CI [1.90–5.87]) for obtaining at least one referral for follow-up care, 13.67 (95% CI [5.60–33.34]) for having four or more hospital admissions and 5.95 (95% CI [1.80–19.63]) for having a diagnoses of primarily substance abuse/misuse. Findings from this study demonstrate that among low- and medium-frequent users a majority of patients are using EMS for reoccurring medical conditions. This could potentially be avoided with better care management. In addition, this study adds to the current literature that illustrates a strong correlation between substance abuse/misuse and high/super-frequent EMS use. For the subgroup analysis among individuals 65 years of age and older, we did not find any of the independent variables included in our model to be statistically significant with frequent EMS use. PMID:26823929

  14. Sterilization: A Review and Update.

    PubMed

    Moss, Chailee; Isley, Michelle M

    2015-12-01

    Sterilization is a frequently used method of contraception. Female sterilization is performed 3 times more frequently than male sterilization, and it can be performed immediately postpartum or as an interval procedure. Methods include mechanical occlusion, coagulation, or tubal excision. Female sterilization can be performed using an abdominal approach, or via laparoscopy or hysteroscopy. When an abdominal approach or laparoscopy is used, sterilization occurs immediately. When hysteroscopy is used, tubal occlusion occurs over time, and additional testing is needed to confirm tubal occlusion. Comprehensive counseling about sterilization should include discussion about male sterilization (vasectomy) and long-acting reversible contraceptive methods. PMID:26598311

  15. Model updating of rotor systems by using Nonlinear least square optimization

    NASA Astrophysics Data System (ADS)

    Jha, A. K.; Dewangan, P.; Sarangi, M.

    2016-07-01

    Mathematical models of structure or machineries are always different from the existing physical system, because the approach of numerical predictions to the behavior of a physical system is limited by the assumptions used in the development of the mathematical model. Model updating is, therefore necessary so that updated model should replicate the physical system. This work focuses on the model updating of rotor systems at various speeds as well as at different modes of vibration. Support bearing characteristics severely influence the dynamics of rotor systems like turbines, compressors, pumps, electrical machines, machine tool spindles etc. Therefore bearing parameters (stiffness and damping) are considered to be updating parameters. A finite element model of rotor systems is developed using Timoshenko beam element. Unbalance response in time domain and frequency response function have been calculated by numerical techniques, and compared with the experimental data to update the FE-model of rotor systems. An algorithm, based on unbalance response in time domain is proposed for updating the rotor systems at different running speeds of rotor. An attempt has been made to define Unbalance response assurance criterion (URAC) to check the degree of correlation between updated FE model and physical model.

  16. Perspective: Update on Idiopathic Intracranial Hypertension

    PubMed Central

    Bruce, Beau B.; Biousse, Valérie; Newman, Nancy J.

    2011-01-01

    Purpose Provide an update on various features of idiopathic intracranial hypertension. Design Perspective. Methods Selected articles on the epidemiology, clinical and imaging features, natural history, pathophysiology, and treatment of idiopathic intracranial hypertension were reviewed and interpreted in the context of the authors’ clinical and research experience. Results Idiopathic intracranial hypertension is primarily a disease of obese women of childbearing age, but it can affect patients of any weight, sex, and age. Although a relatively rare disorder, idiopathic intracranial hypertension’s associated costs in the U.S. entail hundreds of millions of dollars. Even following treatment, headaches are frequently persistent and may require the continued involvement of a neurologist. Quality of life reductions and depression are common among idiopathic intracranial hypertension patients. However, visual dysfunction, especially visual field abnormalities, represents the major morbidity of this disorder, and serial automated perimetry remains the primary mode of patient monitoring. Patients who are men, black, very obese, or anemic are at higher risk of visual loss. Vitamin A metabolism, adipose tissue as an actively secreting endocrine tissue, and cerebral venous abnormalities are areas of active study regarding idiopathic intracranial hypertension’s pathophysiology. Treatment studies show that lumbar puncture is a valuable treatment (in addition to its crucial diagnostic role) and that weight management is critical. However, open questions remain regarding the efficacy of acetazolamide, CSF diversion procedures, and cerebral venous stenting. Conclusions Many questions remain unanswered about idiopathic intracranial hypertension. Ongoing studies, especially an ongoing NIH-funded clinical trial of acetazolamide, should provide more insight into this important, yet poorly understood syndrome of isolated intracranial hypertension. PMID:21696699

  17. Updating knowledge bases with disjunctive information

    SciTech Connect

    Zhang, Yan; Foo, Norman Y.

    1996-12-31

    It is well known that the minimal change principle was widely used in knowledge base updates. However, recent research has shown that conventional minimal change methods, eg. the PMA, are generally problematic for updating knowledge bases with disjunctive information. In this paper, we propose two different approaches to deal with this problem - one is called the minimal change with exceptions (MCE), the other is called the minimal change with maximal disjunctive inclusions (MCD). The first method is syntax-based, while the second is model-theoretic. We show that these two approaches are equivalent for propositional knowledge base updates, and the second method is also appropriate for first order knowledge base updates. We then prove that our new update approaches still satisfy the standard Katsuno and Mendelzon`s update postulates.

  18. Using Collaborative Authoring To Develop a Hypermedia Performance Support System.

    ERIC Educational Resources Information Center

    Tjahjono, Benny; Greenough, Richard

    2002-01-01

    Considers the need of factory workers for support in rapidly changing tasks and suggests that electronic performance support systems can reduce training time, can be updated many times as procedures change, and can allow those with relevant manufacturing expertise to create electronic procedures that support shop floor workers more effectively.…

  19. Tone-dependent error diffusion based on an updated blue-noise model

    NASA Astrophysics Data System (ADS)

    Fung, Yik-Hing; Chan, Yuk-Hee

    2016-01-01

    The conventional blue-noise model that specifies the desired noise characteristics of an ideal halftone has been updated recently, and simulation results showed that the updated model can serve as a better guideline for developing halftone algorithms. At the moment, only a feature-preserving multiscale error diffusion-based algorithm was developed based on the updated noise model. As the algorithm does not support real-time applications, a tone-dependent error diffusion (TDED) algorithm is developed based on the updated noise model. To support the proposed TDED algorithm, we optimize a diffusion filter and a quantizer threshold for each possible input gray level based on the updated noise model, such that the algorithm can adapt its diffusion filter and quantizer according to the input intensity value of a pixel to produce a halftone. Simulation results showed that the proposed TDED algorithm can successfully produce halftones bearing the desired noise characteristics as specified by the updated noise model. As a consequence, it provides better performance than conventional error diffusion-based algorithms in terms of various measures including radially averaged power spectrum density and anisotropy. When processing real images, it can eliminate directional artifacts, regular structure patterns, and unintended sharpening effects in its halftoning outputs.

  20. Update of Thyroid Developmental Genes.

    PubMed

    Stoupa, Athanasia; Kariyawasam, Dulanjalee; Carré, Aurore; Polak, Michel

    2016-06-01

    Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism in iodine-sufficient regions and includes a spectrum of developmental anomalies. The genetic components of TD are complex. Although a sporadic disease, advances in developmental biology have revealed monogenetic forms of TD. Inheritance is not based on a simple Mendelian pattern and additional genetic elements might contribute to the phenotypic spectrum. This article summarizes the key steps of normal thyroid development and provides an update on responsible genes and underlying mechanisms of TD. Up-to-date technologies in genetics and biology will allow us to advance in our knowledge of TD. PMID:27241962

  1. Big bang nucleosynthesis: An update

    SciTech Connect

    Olive, Keith A.

    2013-07-23

    An update on the standard model of big bang nucleosynthesis (BBN) is presented. With the value of the baryon-tophoton ratio determined to high precision by WMAP, standard BBN is a parameter-free theory. In this context, the theoretical prediction for the abundances of D, {sup 4}He, and {sup 7}Li is discussed and compared to their observational determination. While concordance for D and {sup 4}He is satisfactory, the prediction for {sup 7}Li exceeds the observational determination by a factor of about four. Possible solutions to this problem are discussed.

  2. An update on Argonne's AWA

    SciTech Connect

    Rosing, M.; Chojnacki, E.; Gai, W.; Ho, C.; Konecny, R.; Mtingwa, S.; Norem, J.; Schoessow, P.; Simpson, J.

    1991-01-01

    The Argonne Wakefield Accelerator (AWA) is a new research facility which will possess unprecedented research capabilities for the study of wakefields and related areas requiring short, intense electron bunches. The AWA is designed to produce 100 nC, 14 ps (full width) electron bunches at rep rates up to 30 Hz. Phase-1 of the AWA, now under construction, will provide these pulses at 20 MeV for various experiments. Current designs, related research and development, and construction status are presented in this general overview and project update. 6 refs., 4 figs.

  3. Current Updates on Choanal Atresia

    PubMed Central

    Kwong, Kelvin M.

    2015-01-01

    Choanal atresia (CA) is a relatively uncommon but well-recognized condition characterized by the anatomical closure of the posterior choanae in the nasal cavity. Since the original description back in the early eighteenth century, there have been controversies regarding its exact pathogenesis, the optimal surgical approach, and the use of adjunct treatments such as post-surgical stenting and anti-neoplastic agents, despite of abundant literature available. The emergence and development of new technologies play a significant role in the management of this condition. This review provides a comprehensive clinical update on CA and identifies areas for future study based on the existing available literature. PMID:26106591

  4. Cerebral Palsy: A Dental Update

    PubMed Central

    Sehrawat, Nidhi; Bansal, Kalpana; Chopra, Radhika

    2014-01-01

    ABSTRACT Special and medically compromised patients present a unique population that challenges the dentist’s skill and knowledge. Providing oral care to people with cerebral palsy (CP) requires adaptation of the skills we use everyday. In fact, most people with mild or moderate forms of CP can be treated successfully in the general practice setting. This article is to review various dental considerations and management of a CP patient. How to cite this article: Sehrawat N, Marwaha M, Bansal K, Chopra R. Cerebral Palsy: A Dental Update. Int J Clin Pediatr Dent 2014;7(2):109-118. PMID:25356010

  5. Autonomy Support for Online Students

    ERIC Educational Resources Information Center

    Lee, Eunbae; Pate, Joseph A.; Cozart, Deanna

    2015-01-01

    Despite the rapid growth of online learning in higher education, the dropout rates for online courses has reached 50 percent. Lack of student engagement rank as a critical reason for frequent online course dropout. This article discusses autonomy support as a strategy to enhance online students' intrinsic motivation and engagement. Drawing from…

  6. ISS Update: Burning and Suppression of Solids

    NASA Video Gallery

    ISS Update Commentator Pat Ryan interviews Paul Ferkul, Principal Investigator for the Burning and Suppression of Solids (BASS) experiment, about performing combustion experiments in microgravity. ...

  7. Nutritional Support

    MedlinePlus

    Nutritional support is therapy for people who cannot get enough nourishment by eating or drinking. You may need ... absorb nutrients through your digestive system You receive nutritional support through a needle or catheter placed in your ...

  8. Preliminary Analysis of Interteaching's Frequent Examinations Component in the Community College Classroom

    ERIC Educational Resources Information Center

    Felderman, Theresa A.

    2014-01-01

    Interteaching has shown to be an effective alternative to traditional lecture in a number of studies, but thorough analyses of its components, including frequent exams, is limited. Research suggests that increasing the frequency of exams may improve student learning. This study assessed the effectiveness of interteaching's frequent exams…

  9. Reliability of Frequent Retrospective Behavior Ratings for Elementary School Students with EBD

    ERIC Educational Resources Information Center

    Burke, Mack D.; Vannest, Kimberly; Davis, John; Davis, Cole; Parker, Richard

    2009-01-01

    This study is a preliminary examination of the reliability of frequent retrospective teacher behavior ratings. Frequent retrospective behavior ratings are an approach for creating scales that can be used to monitor individual behavioral progress. In this study, the approach is used to progress monitor behavioral individualized education plan goals…

  10. Implementing Response to Intervention: Practices and Perspectives from Five Schools--Frequently Asked Questions

    ERIC Educational Resources Information Center

    Tackett, Kathryn Klingler; Roberts, Greg; Baker, Scott; Scammacca, Nancy

    2009-01-01

    One question frequently arises in the work of the Regional Comprehensive Centers: "What are states, districts, and schools doing about RTI?" This document addresses that question, with particular focus on instruction and the implementation of effective practices. It uses a frequently asked questions (FAQs) format, with answers based on the…

  11. Spending Time with Teacher: Characteristics of Preschoolers Who Frequently Elicit versus Initiate Interactions with Teachers.

    ERIC Educational Resources Information Center

    Coplan, Robert J.; Prakash, Kavita

    2003-01-01

    Explored interface between preschoolers' socio-emotional characteristics and interactions with teachers during free play. Found that children who most frequently initiated teacher interaction behaved more aggressively than peers and were so rated by teachers. Children who most frequently received teacher initiations were more shy and anxious.…

  12. Frequent Emergency Department Use among Released Prisoners with HIV: Characterization Including a Novel Multimorbidity Index

    PubMed Central

    Meyer, Jaimie P.; Qiu, Jingjun; Chen, Nadine E.; Larkin, Gregory L.; Altice, Frederick L.

    2012-01-01

    Objectives To characterize the medical, social, and psychiatric correlates of frequent emergency department (ED) use among released prisoners with human immunodeficiency virus (HIV). Methods Data on all ED visits by 151 released prisoners with HIV on antiretroviral therapy were prospectively collected for 12 months. Correlates of frequent ED use, defined as having two or more ED visits post-release, were described using univariate and multivariate models, and generated medical, psychiatric, and social multi-morbidity indices. Results Forty-four (29%) of the 151 participants were defined as frequent ED users, accounting for 81% of the 227 ED visits. Frequent ED users were more likely than infrequent or non-users to be female; have chronic medical illnesses that included seizures, asthma, and migraines; and have worse physical health-related quality of life. In multivariate Poisson regression models, frequent ED use was associated with lower physical health-related quality of life (odds ratio [OR] 0.95, p = 0.02), and having not had pre-release discharge planning (OR 3.16, p = 0.04). Frequent ED use was positively correlated with increasing psychiatric multi-morbidity index values. Conclusions Among released prisoners with HIV, frequent ED use is driven primarily by extensive co-morbid medical and psychiatric illness. Frequent ED users were also less likely to have received pre-release discharge planning, suggesting missed opportunities for seamless linkages to care. PMID:23570481

  13. EPAct Alternative Fuel Transporation Program - State and Alternative Fuel Provider Fleets: Frequently Asked Questions

    SciTech Connect

    2010-03-01

    Factsheet answering frequently asked questions about the U.S. Department of Energy's Alternative Fuel Transportation Program (the Program) that implements provisions of Titles III–V of the Energy Policy Act of 1992 (EPAct). Answers to questions that are frequently asked about the Program by managers of state government and alternative fuel provider fleets are provided in the factsheet.

  14. Frequent Visitors: Somatization in School-Age Children and Implications for School Nurses

    ERIC Educational Resources Information Center

    Shannon, Robin Adair; Bergren, Martha Dewey; Matthews, Alicia

    2010-01-01

    There is a gap in the nursing literature regarding children who frequently visit school nurses' offices with recurrent unexplained physical symptoms. A review of the scientific health literature was undertaken to examine the clinical presentation, associated variables, and implications for school nurses regarding children who are frequent school…

  15. The Effect of Frequent Quizzes on Short- and Long-Term Academic Performance.

    ERIC Educational Resources Information Center

    Geist, James R.; Soehren, Stephen E.

    1997-01-01

    This study examined effects of frequent quizzes on dental student performance in a course on introductory radiology. Results indicated the group (N=36) with frequent quizzes performed significantly better than the control group (n=35) on midterm and final examinations (but not post-tests), and assessed course content and instructor more…

  16. Questions Frequently Asked about Vocational Education. Special Publication Series No. 57.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. National Center for Research in Vocational Education.

    This document offers the best available answers to questions frequently asked about vocational education by policymakers in vocational education at the state and local level. It is divided into two sections. The first section contains 15 frequently asked questions about vocational education effects and practices, each of which is followed by a…

  17. Linking Online Gaming and Addictive Behavior: Converging Evidence for a General Reward Deficiency in Frequent Online Gamers

    PubMed Central

    Hahn, Tim; Notebaert, Karolien Hilde; Dresler, Thomas; Kowarsch, Linda; Reif, Andreas; Fallgatter, Andreas J.

    2014-01-01

    Millions of people regularly play so-called massively multiplayer online role playing games (MMORPGs). Recently, it has been argued that MMORPG overuse is becoming a significant health problem worldwide. Symptoms such as tolerance, withdrawal, and craving have been described. Based on behavioral, resting state, and task-related neuroimaging data, we test whether frequent players of the MMORPG “World of Warcraft” (WoW) – similar to drug addicts and individuals with an increased risk for addictions – show a generally deficient reward system. In frequent players of the MMORPG “World of Warcraft” (WoW-players) and in a control group of non-gamers we assessed (1) trait sensitivity to reward (SR), (2) BOLD responses during monetary reward processing in the ventral striatum, and (3) ventral-striatal resting-state dynamics. We found a decreased neural activation in the ventral striatum during the anticipation of both small and large monetary rewards. Additionally, we show generally altered neurodynamics in this region independent of any specific task for WoW players (resting state). On the behavioral level, we found differences in trait SR, suggesting that the reward processing deficiencies found in this study are not a consequence of gaming, but predisposed to it. These findings empirically support a direct link between frequent online gaming and the broad field of behavioral and drug addiction research, thus opening new avenues for clinical interventions in addicted gamers and potentially improving the assessment of addiction-risk in the vast population of frequent gamers. PMID:25426039

  18. Getting support when your child has cancer

    MedlinePlus

    ... news can be tiring. Online e-mails or social networks are a great way to update the people in your life. You can also receive kind words of support this way. ... know if they are giving you or your child too much attention

  19. Acute Intermittent Porphyria in Argentina: An Update

    PubMed Central

    Cerbino, Gabriela Nora; Gerez, Esther Noemí; Varela, Laura Sabina; Melito, Viviana Alicia; Parera, Victoria Estela; Rossetti, María Victoria

    2015-01-01

    Porphyrias are a group of metabolic diseases that arise from deficiencies in the heme biosynthetic pathway. A partial deficiency in hydroxymethylbilane synthase (HMBS) produces a hepatic disorder named Acute Intermittent Porphyria (AIP); the acute porphyria is more frequent in Argentina. In this paper we review the results obtained for 101 Argentinean AIP families and 6 AIP families from foreign neighbour countries studied at molecular level at Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP). Thirty-five different mutations were found, of which 14 were described for the first time in our population. The most prevalent type of mutations was the missense mutations (43%) followed by splice defects (26%) and small deletions (20%). An odd case of a double heterozygous presentation of AIP in a foreign family from Paraguay is discussed. Moreover, it can be noted that 38 new families were found carrying the most frequent mutation in Argentina (p.G111R), increasing to 55.66% the prevalence of this genetic change in our population and adding further support to our previous hypothesis of a founder effect for this mutation in Argentina. Identification of patients with an overt AIP is important because treatment depends on an accurate diagnosis, but more critical is the identification of asymptomatic relatives to avoid acute attacks which may progress to death. PMID:26075277

  20. Successful GP intervention with frequent attenders in primary care: randomised controlled trial

    PubMed Central

    Bellón, Juan Ángel; Rodríguez-Bayón, Antonina; de Dios Luna, Juan; Torres-González, Francisco

    2008-01-01

    Background Frequent attenders to GP clinics can place an unnecessary burden on primary care. Interventions to reduce frequent attendance have had mixed results. Aim To assess the effectiveness of a GP intervention to reduce frequent-attender consultations. Design of study Randomised controlled trial with frequent attenders divided into an intervention group and two control groups (one control group was seen by GPs also providing care to patients undergoing the intervention). Setting A health centre in southern Spain. Method Six GPs and 209 randomly-selected frequent attenders participated. Three GPs were randomly allocated to perform the new intervention: of the 137 frequent attenders registered with these three GPs, 66 were randomly allocated to receive the intervention (IG) and 71 to a usual care control group (CG2). The other three GPs offered usual care to the other 72 frequent attenders (CG1). The main outcome measure was the total number of consultations 1 year post-intervention. Baseline measurements were recorded of sociodemographic characteristics, provider–user interface, chronic illnesses, and psychosocial variables. GPs allocated to the new intervention received 15 hours' training which incorporated biopsychosocial, organisational, and relational approaches. After 1 year of follow-up frequent attenders were contacted. An intention-to-treat analysis was used. Results A multilevel model was built with three factors: time, patient, and doctor. After adjusting for covariates, the mean number of visits at 1 year in IG was 13.10 (95% confidence interval [CI] = 11.39 to 14.94); in the CG1 group was 19.37 (95% CI = 17.31 to 21.55); and in the CG2 group this was 16.72 (95% CI =14.84 to 18.72). Conclusion The new intervention with GPs resulted in a significant and relevant reduction in frequent-attender consultations. Although further trials are needed, this intervention is recommended to GPs interested in reducing consultations by their frequent attenders

  1. Risk Assessment Update: Russian Segment

    NASA Technical Reports Server (NTRS)

    Christiansen, Eric; Lear, Dana; Hyde, James; Bjorkman, Michael; Hoffman, Kevin

    2012-01-01

    BUMPER-II version 1.95j source code was provided to RSC-E- and Khrunichev at January 2012 MMOD TIM in Moscow. MEMCxP and ORDEM 3.0 environments implemented as external data files. NASA provided a sample ORDEM 3.0 g."key" & "daf" environment file set for demonstration and benchmarking BUMPER -II v1.95j installation at the Jan-12 TIM. ORDEM 3.0 has been completed and is currently in beta testing. NASA will provide a preliminary set of ORDEM 3.0 ".key" & ".daf" environment files for the years 2012 through 2028. Bumper output files produced using the new ORDEM 3.0 data files are intended for internal use only, not for requirements verification. Output files will contain these words ORDEM FILE DESCRIPTION = PRELIMINARY VERSION: not for production. The projectile density term in many BUMPER-II ballistic limit equations will need to be updated. Cube demo scripts and output files delivered at the Jan-12 TIM have been updated for the new ORDEM 3.0 data files. Risk assessment results based on ORDEM 3.0 and MEM will be presented for the Russian Segment (RS) of ISS.

  2. Updating outdated predictive accident models.

    PubMed

    Wood, A G; Mountain, L J; Connors, R D; Maher, M J; Ropkins, K

    2013-06-01

    Reliable predictive accident models (PAMs) (also referred to as safety performance functions (SPFs)) are essential to design and maintain safe road networks however, ongoing changes in road and vehicle design coupled with road safety initiatives, mean that these models can quickly become dated. Unfortunately, because the fitting of sophisticated PAMs including a wide range of explanatory variables is not a trivial task, available models tend to be based on data collected many years ago and seem unlikely to give reliable estimates of current accidents. Large, expensive studies to produce new models are likely to be, at best, only a temporary solution. This paper thus seeks to develop a practical and efficient methodology to allow currently available PAMs to be updated to give unbiased estimates of accident frequencies at any point in time. Two principal issues are examined: the extent to which the temporal transferability of predictive accident models varies with model complexity; and the practicality and efficiency of two alternative updating strategies. The models used to illustrate these issues are the suites of models developed for rural dual and single carriageway roads in the UK. These are widely used in several software packages in spite of being based on data collected during the 1980s and early 1990s. It was found that increased model complexity by no means ensures better temporal transferability and that calibration of the models using a scale factor can be a practical alternative to fitting new models. PMID:23510788

  3. Incontinentia pigmenti diagnostic criteria update.

    PubMed

    Minić, S; Trpinac, D; Obradović, M

    2014-06-01

    In 1993 diagnostic criteria for incontinentia pigmenti (IP), a genodermatosis in which skin changes are usually combined with anomalies of other organs, were established. Approximately a decade ago, IKBKG gene mutation was discovered as a cause for IP. This finding has not been included in IP diagnosis so far. In addition, literature data pointed out a few other clinical findings as possible IP diagnostic criteria. Literature facts concerning IP diagnosis were analyzed. Different organ anomalies, their frequency and severity, were analyzed in the context of applicability as IP diagnostic criteria. Taking into account analyzed data from the literature, the proposal of updated IP diagnostic criteria was presented. We propose as major criteria one of the stages of IP skin lesions. As updated IP minor criteria in our proposal we included: dental, ocular; central nervous system (CNS), hair, nail, palate, breast and nipple anomalies; multiple male miscarriages, and IP pathohistological findings. In the diagnosis of IP, the presence of IKBKG mutation typical for IP, and existence of family relatives with diagnosed IP are taken into account. PMID:23802866

  4. An Update on Planet Nine

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2016-07-01

    Whats the news coming from the research world on the search for Planet Nine? Read on for an update from a few of the latest studies.Artists illustration of Planet Nine, a hypothesized Neptune-sized planet orbiting in the distant reaches of our solar system. [Caltech/Robert Hurt]What is Planet Nine?In January of this year, Caltech researchers Konstantin Batygin and Mike Brown presented evidence of a distant ninth planet in our solar system. They predicted this planet to be of a mass and volume consistent with a super-Earth, orbiting on a highly eccentric pathwith a period of tens of thousands of years.Since Batygin and Browns prediction, scientists have been hunting for further signs of Planet Nine. Though we havent yet discovered an object matching its description, we have come up with new strategies for finding it, we set some constraints on where it might be, and we made some interesting theoretical predictions about its properties.Visualizations of the resonant orbits of the four longest-period Kuiper belt objects, depicted in a frame rotating with the mean angular velocity of Planet Nine. Planet Nines position is on the right (with the trace of possible eccentric orbits e=0.17 and e=0.4 indicated in red). [Malhotra et al 2016]Here are some of the newest constraints on Planet Nine from studies published just within the past two weeks.Resonant OrbitsRenu Malhotra (University of Arizonas Lunar and Planetary Laboratory) and collaborators present further evidence of the shaping of solar system orbits by the hypothetical Planet Nine. The authors point out that the four longest-period Kuiper belt objects (KBOs) have orbital periods close to integer ratios with each other. Could it be that these outer KBOs have become locked into resonant orbits with a distant, massive body?The authors find that a distant planet orbiting with a period of ~17,117 years and a semimajor axis ~665 AU would have N/1 and N/2 period ratios with these four objects. If this is correct, it

  5. An Update on Planet Nine

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2016-07-01

    Whats the news coming from the research world on the search for Planet Nine? Read on for an update from a few of the latest studies.Artists illustration of Planet Nine, a hypothesized Neptune-sized planet orbiting in the distant reaches of our solar system. [Caltech/Robert Hurt]What is Planet Nine?In January of this year, Caltech researchers Konstantin Batygin and Mike Brown presented evidence of a distant ninth planet in our solar system. They predicted this planet to be of a mass and volume consistent with a super-Earth, orbiting on a highly eccentric pathwith a period of tens of thousands of years.Since Batygin and Browns prediction, scientists have been hunting for further signs of Planet Nine. Though we havent yet discovered an object matching its description, we have come up with new strategies for finding it, we set some constraints on where it might be, and we made some interesting theoretical predictions about its properties.Visualizations of the resonant orbits of the four longest-period Kuiper belt objects, depicted in a frame rotating with the mean angular velocity of Planet Nine. Planet Nines position is on the right (with the trace of possible eccentric orbits e=0.17 and e=0.4 indicated in red). [Malhotra et al 2016]Here are some of the newest constraints on Planet Nine from studies published just within the past two weeks.Resonant OrbitsRenu Malhotra (University of Arizonas Lunar and Planetary Laboratory) and collaborators present further evidence of the shaping of solar system orbits by the hypothetical Planet Nine. The authors point out that the four longest-period Kuiper belt objects (KBOs) have orbital periods close to integer ratios with each other. Could it be that these outer KBOs have become locked into resonant orbits with a distant, massive body?The authors find that a distant planet orbiting with a period of ~17,117 years and a semimajor axis ~665 AU would have N/1 and N/2 period ratios with these four objects. If this is correct, it

  6. The Hazards Data Distribution System update

    USGS Publications Warehouse

    Jones, Brenda K.; Lamb, Rynn

    2010-01-01

    After a major disaster, a satellite image or a collection of aerial photographs of the event is frequently the fastest, most effective way to determine its scope and severity. The U.S. Geological Survey (USGS) Emergency Operations Portal provides emergency first responders and support personnel with easy access to imagery and geospatial data, geospatial Web services, and a digital library focused on emergency operations. Imagery and geospatial data are accessed through the Hazards Data Distribution System (HDDS). HDDS historically provided data access and delivery services through nongraphical interfaces that allow emergency response personnel to select and obtain pre-event baseline data and (or) event/disaster response data. First responders are able to access full-resolution GeoTIFF images or JPEG images at medium- and low-quality compressions through ftp downloads. USGS HDDS home page: http://hdds.usgs.gov/hdds2/

  7. Longevity of emplacement drift ground support materials

    SciTech Connect

    Tang, David

    2000-04-01

    The purpose of this analysis is to evaluate the factors affecting the longevity of emplacement drift ground support materials and to develop a basis for the selection of materials for ground support that will function throughout the preclosure period of a potential repository at Yucca Mountain. The Development Plan (DP) for this analysis is given in Longevity of Emplacement Drift Ground Support Materials (CRWMS M and O 1999a). The objective of this analysis is to update the previous analysis (CRWMS M and O 2000a) to account for related changes in the Ground Control System Description Document (CRWMS M and O 2000b), the Monitored Geologic Repository Project Description Document (CRWMS M and O 1999b), and in environmental conditions, and to provide updated information on candidate ground support materials.

  8. ZFIN: enhancements and updates to the zebrafish model organism database

    PubMed Central

    Bradford, Yvonne; Conlin, Tom; Dunn, Nathan; Fashena, David; Frazer, Ken; Howe, Douglas G.; Knight, Jonathan; Mani, Prita; Martin, Ryan; Moxon, Sierra A. T.; Paddock, Holly; Pich, Christian; Ramachandran, Sridhar; Ruef, Barbara J.; Ruzicka, Leyla; Bauer Schaper, Holle; Schaper, Kevin; Shao, Xiang; Singer, Amy; Sprague, Judy; Sprunger, Brock; Van Slyke, Ceri; Westerfield, Monte

    2011-01-01

    ZFIN, the Zebrafish Model Organism Database, http://zfin.org, serves as the central repository and web-based resource for zebrafish genetic, genomic, phenotypic and developmental data. ZFIN manually curates comprehensive data for zebrafish genes, phenotypes, genotypes, gene expression, antibodies, anatomical structures and publications. A wide-ranging collection of web-based search forms and tools facilitates access to integrated views of these data promoting analysis and scientific discovery. Data represented in ZFIN are derived from three primary sources: curation of zebrafish publications, individual research laboratories and collaborations with bioinformatics organizations. Data formats include text, images and graphical representations. ZFIN is a dynamic resource with data added daily as part of our ongoing curation process. Software updates are frequent. Here, we describe recent additions to ZFIN including (i) enhanced access to images, (ii) genomic features, (iii) genome browser, (iv) transcripts, (v) antibodies and (vi) a community wiki for protocols and antibodies. PMID:21036866

  9. A novel meta-analytic approach: Mining frequent co-activation patterns in neuroimaging databases

    PubMed Central

    Caspers, Julian; Zilles, Karl; Beierle, Christoph; Rottschy, Claudia; Eickhoff, Simon B.

    2016-01-01

    In recent years, coordinate-based meta-analyses have become a powerful and widely used tool to study coactivity across neuroimaging experiments, a development that was supported by the emergence of large-scale neuroimaging databases like BrainMap. However, the evaluation of co-activation patterns is constrained by the fact that previous coordinate-based meta-analysis techniques like Activation Likelihood Estimation (ALE) and Multilevel Kernel Density Analysis (MKDA) reveal all brain regions that show convergent activity within a dataset without taking into account actual within-experiment co-occurrence patterns. To overcome this issue we here propose a novel meta-analytic approach named PaMiNI that utilizes a combination of two well-established data-mining techniques, Gaussian mixture modeling and the Apriori algorithm. By this, PaMiNI enables a data-driven detection of frequent co-activation patterns within neuroimaging datasets. The feasibility of the method is demonstrated by means of several analyses on simulated data as well as a real application. The analyses of the simulated data show that PaMiNI identifies the brain regions underlying the simulated activation foci and perfectly separates the co-activation patterns of the experiments in the simulations. Furthermore, PaMiNI still yields good results when activation foci of distinct brain regions become closer together or if they are non-Gaussian distributed. For the further evaluation, a real dataset on working memory experiments is used, which was previously examined in an ALE meta-analysis and hence allows a cross-validation of both methods. In this latter analysis, PaMiNI revealed a fronto-parietal “core” network of working memory and furthermore indicates a left-lateralization in this network. Finally, to encourage a widespread usage of this new method, the PaMiNI approach was implemented into a publicly available software system. PMID:24365675

  10. The effect of ageing on recollection: the role of the binding updating process.

    PubMed

    Boujut, Arnaud; Clarys, David

    2016-10-01

    The aim of this study was to highlight the underlying process responsible for the age-related deficit in recollection. Through two experiments using the Remember-Know-Guess procedure (Gardiner, J. M., & Richardson-Klavehn, A. [2000]. Remembering and knowing. In The Oxford handbook of memory (pp. 229-244). New York, NY: Oxford University Press) in recognition, we manipulated the opportunity to update bindings between target items and their encoding context, in young and older adults. In the first experiment we impaired the binding updating process during the encoding of items, while in the second we supported this process. The results indicated that the "Remember" responses in the younger group were specifically reduced by the impairment of the binding updating process (Exp. 1), suggesting that this ability is useful for them to encode a specific episode. Conversely, only the "Remember" responses in the older group were improved in accuracy by supporting the binding updating process (Exp. 2), suggesting that their weakness in this ability is the source of their failure to improve the accuracy of their memories. The overall results support the hypothesis that the age-related decline in episodic memory is partly due to a greater vulnerability to interference on bindings, impairing the ability to update content-context bindings as and when events occur. PMID:27560656

  11. Part C Updates. 10th Edition

    ERIC Educational Resources Information Center

    Goode, Sue; Lazara, Alex; Danaher, Joan

    2008-01-01

    "Part C Updates" is a compilation of information on various aspects of the Early Intervention Program for Infants and Toddlers with Disabilities (Part C) of the Individuals with Disabilities Education Act (IDEA). This is the tenth volume in a series of compilations, which included two editions of Part H Updates, the former name of the program.…

  12. Census in Schools Educator Update, November 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) New Web Site for the…

  13. Census in Schools Educator Update, May 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census: The…

  14. Census in Schools Educator Update, February 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census Video: A…

  15. 40 CFR 55.12 - Consistency updates.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Consistency updates. 55.12 Section 55.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) OUTER CONTINENTAL SHELF AIR REGULATIONS § 55.12 Consistency updates. (a) The Administrator will...

  16. Spatial Updating of Environments Described in Texts

    ERIC Educational Resources Information Center

    Avraamides, Marios N.

    2003-01-01

    People update egocentric spatial relations in an effortless and on-line manner when they move in the environment, but not when they only imagine themselves moving. In contrast to previous studies, the present experiments examined egocentric updating with spatial scenes that were encoded linguistically instead of perceived directly. Experiment 1…

  17. 34 CFR 668.55 - Updating information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Updating information. 668.55 Section 668.55 Education... Information § 668.55 Updating information. (a)(1) Unless the provisions of paragraph (a)(2) or (a)(3) of this... applicant to verify the information contained in his or her application for assistance in an award year...

  18. 34 CFR 668.55 - Updating information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false Updating information. 668.55 Section 668.55 Education... Information § 668.55 Updating information. (a)(1) Unless the provisions of paragraph (a)(2) or (a)(3) of this... applicant to verify the information contained in his or her application for assistance in an award year...

  19. Control of Interference during Working Memory Updating

    ERIC Educational Resources Information Center

    Szmalec, Arnaud; Verbruggen, Frederick; Vandierendonck, Andre; Kemps, Eva

    2011-01-01

    The current study examined the nature of the processes underlying working memory updating. In 4 experiments using the n-back paradigm, the authors demonstrate that continuous updating of items in working memory prevents strong binding of those items to their contexts in working memory, and hence leads to an increased susceptibility to proactive…

  20. 40 CFR 68.190 - Updates.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 16 2012-07-01 2012-07-01 false Updates. 68.190 Section 68.190 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.190 Updates. (a) The owner or operator...

  1. Tech Plan Update Electronic Forms Preview.

    ERIC Educational Resources Information Center

    Massachusetts State Dept. of Education, Malden.

    This packet of "Tech Plan Update" Preview forms is provided by the Massachusetts Department of Education for planning purposes for the July 1, 2000 to June 30, 2001 fiscal year, prior to submitting "Tech Plan Update" electronic forms online. The first section, Local Technology Plan Data Collection Form, is divided by benchmarks, as follows:…

  2. 77 FR 41258 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... Proposed FOIA Fee Schedule, 77 FR 32433. No comments were received in response to that notice, and the... Schedule Update went into effect on July 29, 2011. 76 FR 43819. Board Action Accordingly, the Board issues... SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety...

  3. 75 FR 17641 - Updating Fire Safety Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... AFFAIRS 38 CFR Parts 17 and 59 RIN 2900-AN57 Updating Fire Safety Standards AGENCY: Department of Veterans..., including standards for fire safety and heating and cooling systems. The proposed amendments would help.... Comments should indicate that they are submitted in response to ``RIN 2900-AN57--Updating Fire...

  4. Census in Schools Educator Update, February 2010

    ERIC Educational Resources Information Center

    US Census Bureau, 2010

    2010-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter includes the following items: (1) Have You Seen the Census…

  5. Part C Updates. 11th Edition

    ERIC Educational Resources Information Center

    Danaher, Joan; Goode, Sue; Lazara, Alex

    2010-01-01

    "Part C Updates" is a compilation of information on various aspects of the Early Intervention Program for Infants and Toddlers with Disabilities (Part C) of the Individuals with Disabilities Education Act (IDEA). This is the eleventh volume in a series of compilations, which included two editions of Part H Updates, the former name of the program.…

  6. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  7. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  8. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  9. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  10. 10 CFR 26.57 - Authorization update.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Authorization update. 26.57 Section 26.57 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.57 Authorization update. (a) Before granting authorization to an individual whose authorization has been interrupted...

  11. Census in Schools Educator Update, April 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census; (2)…

  12. Census in Schools Educator Update, June 2009

    ERIC Educational Resources Information Center

    US Census Bureau, 2009

    2009-01-01

    The "Census in Schools Educator Update" is sent to educators and educational organizations periodically to keep them informed about current and upcoming census data and to provide ideas about how to use data in the classroom. This issue of the "Census in Schools Educator Update" newsletter focuses on the following topics: (1) 2010 Census; (2)…

  13. Better Plants Progress Update Fall 2013

    SciTech Connect

    none,

    2013-09-23

    This Progress Update summarizes the significant energy saving achievements and cumulative cost savings made by these industry leaders from 2010-2012. The update also shares the plans and priorities over the next year for the Better Plants Program to continue to advance energy efficiency in the industrial sector.

  14. 1 CFR 8.3 - Periodic updating.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Periodic updating. 8.3 Section 8.3 General... the intent and purpose of the Administrative Committee as stated in § 8.1. (b) Staggered publication... before the “As of” date. Thus, each title updated as of July 1 each year will reflect all...

  15. 1 CFR 8.3 - Periodic updating.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Periodic updating. 8.3 Section 8.3 General... the intent and purpose of the Administrative Committee as stated in § 8.1. (b) Staggered publication... before the “As of” date. Thus, each title updated as of July 1 each year will reflect all...

  16. 1 CFR 8.3 - Periodic updating.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Periodic updating. 8.3 Section 8.3 General... the intent and purpose of the Administrative Committee as stated in § 8.1. (b) Staggered publication... before the “As of” date. Thus, each title updated as of July 1 each year will reflect all...

  17. 1 CFR 8.3 - Periodic updating.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Periodic updating. 8.3 Section 8.3 General... the intent and purpose of the Administrative Committee as stated in § 8.1. (b) Staggered publication... before the “As of” date. Thus, each title updated as of July 1 each year will reflect all...

  18. 1 CFR 8.3 - Periodic updating.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Periodic updating. 8.3 Section 8.3 General... the intent and purpose of the Administrative Committee as stated in § 8.1. (b) Staggered publication... before the “As of” date. Thus, each title updated as of July 1 each year will reflect all...

  19. SCORPION II persistent surveillance system update

    NASA Astrophysics Data System (ADS)

    Coster, Michael; Chambers, Jon

    2010-04-01

    This paper updates the improvements and benefits demonstrated in the next generation Northrop Grumman SCORPION II family of persistent surveillance and target recognition systems produced by the Xetron Campus in Cincinnati, Ohio. SCORPION II reduces the size, weight, and cost of all SCORPION components in a flexible, field programmable system that is easier to conceal and enables integration of over fifty different Unattended Ground Sensor (UGS) and camera types from a variety of manufacturers, with a modular approach to supporting multiple Line of Sight (LOS) and Beyond Line of Sight (BLOS) communications interfaces. Since 1998 Northrop Grumman has been integrating best in class sensors with its proven universal modular Gateway to provide encrypted data exfiltration to Common Operational Picture (COP) systems and remote sensor command and control. In addition to feeding COP systems, SCORPION and SCORPION II data can be directly processed using a common sensor status graphical user interface (GUI) that allows for viewing and analysis of images and sensor data from up to seven hundred SCORPION system gateways on single or multiple displays. This GUI enables a large amount of sensor data and imagery to be used for actionable intelligence as well as remote sensor command and control by a minimum number of analysts.

  20. Neurodevelopmental model of schizophrenia: update 2012

    PubMed Central

    Rapoport, JL; Giedd, JN; Gogtay, N

    2012-01-01

    The neurodevelopmental model of schizophrenia, which posits that the illness is the end state of abnormal neurodevelopmental processes that started years before the illness onset, is widely accepted, and has long been dominant for childhood-onset neuropsychiatric disorders. This selective review updates our 2005 review of recent studies that have impacted, or have the greatest potential to modify or extend, the neurodevelopmental model of schizophrenia. Longitudinal whole-population studies support a dimensional, rather than categorical, concept of psychosis. New studies suggest that placental pathology could be a key measure in future prenatal high-risk studies. Both common and rare genetic variants have proved surprisingly diagnostically nonspecific, and copy number variants (CNVs) associated with schizophrenia are often also associated with autism, epilepsy and intellectual deficiency. Large post-mortem gene expression studies and prospective developmental multi-modal brain imaging studies are providing critical data for future clinical and high-risk developmental brain studies. Whether there can be greater molecular specificity for phenotypic characterization is a subject of current intense study and debate, as is the possibility of neuronal phenotyping using human pluripotent-inducible stem cells. Biological nonspecificity, such as in timing or nature of early brain development, carries the possibility of new targets for broad preventive treatments. PMID:22488257