Dain, S J; McCarthy, A K; Chan-Ling, T
The investigation of the role of visual and ocular characteristics of visual display unit (VDU) operators in the causation of subjective visual fatigue has not been reported previously. A retrospective study in which the visual and ocular characteristics of symptomatic and asymptomatic VDU operators was carried out in order to determine whether such a relation could be demonstrated. Three groups totaling 1013 VDU operators from two semigovernment organizations were assessed using either a full eye examination or a modified clinical screening technique. Before examination, the operators completed a short questionnaire on the symptoms they experienced when using VDU's. Significant differences between the symptomatic and asymptomatic operators in some groups were found for over-refraction (spherical equivalent and cylindrical) and near horizontal heterophoria. Despite the existence of this relation, no basis for valid visual standards could be established. In particular, no basis was found for the automatic prescribing of low plus corrections and, in the absence of clearly definable visual standards, the involvement of clinical judgment in the assessment of operators was found to be necessary. PMID:3364524
Crosby, Erin C.; Abernethy, Melinda; Berger, Mitchell B.; DeLancey, John O.; Fenner, Dee E.; Morgan, Daniel M.
OBJECTIVE Complications from transvaginal mesh placed for prolapse often require operative management. The aim of this study is to describe the outcomes of vaginal mesh removal. METHODS A retrospective review of all patients having surgery by the Urogynecology group in the Department of Obstetrics & Gynecology at our institution for a complication of transvaginal mesh placed for prolapse was performed. Demographics, presenting symptoms, surgical procedures, and postoperative symptoms were abstracted. Comparative statistics were performed using the chi-squared or Fisher’s exact test with significance at p<0.05. RESULTS Between January 2008 and April 2012, 90 patients had surgery for complications related to vaginal mesh and 84 had follow-up data. The most common presenting signs and symptoms were: mesh exposure 62% (n=56), pain 64% (n=58), and dyspareunia 48% (n=43). During operative management, mesh erosion was encountered unexpectedly in a second area of the vagina in 5% (n=4), in the bladder in 1% (n=1), and in the bowel in 2% (n=2). After vaginal mesh removal, 51% (n=43) had resolution of all presenting symptoms. Mesh exposure was treated successfully in 95% of cases, while pain was only successfully treated in 51% of women. CONCLUSION Removal of vaginal mesh is helpful in relieving symptoms of presentation. Patients can be reassured that exposed mesh can almost always be successfully managed surgically, but pain and dyspareunia are only resolved completely in half of cases. PMID:24463673
Palmer, K.; Crane, G.; Inskip, H.
OBJECTIVES: To survey the prevalence and severity of hand-arm vibration syndrome symptoms (HAVS), and to estimate past and current exposure to hand held vibrating tools in a sample of gas distribution operatives breaking and re-instating road surfaces. METHODS: 153 gas distribution operatives (participation rate 81%) from three company districts were assessed by an administered questionnaire, a clinical examination, and a simple cold challenge test to the hands. Exposure histories were taken aided by a picture album of past and current tools. Information was obtained from several sources on the likely vibratory characteristics of those tools. Estimates were thus obtained of the frequency of blanching and neurological complaints in operatives, and of their lifetime hours of exposure and lifetime dose of vibration. RESULTS: On average, the sample had spent 16 years in employment involving use of vibratory tools. 24% had symptoms or signs of blanching after use of tools in the industry; 46% had troublesome persistent complaints of paraesthesiae or numbness, and these symptoms extended into the hands or arms in 18% of workers. In 5.9% the distribution of symptoms was suggestive of carpal tunnel syndrome; and of ulnar nerve entrapment in a further 3.9%. The risks of blanching and neurological complaints rose significantly with lifetime hours of use of vibrating tools and lifetime dose of vibration. Symptoms were generally mild and apparent only after a prolonged interval, but there were exceptions, and cases had occurred after lower recent exposures. CONCLUSIONS: It has been suggested that aspects of the gas distribution operative's work mitigate against the risk normally anticipated from use of pneumatic road breaking tools. By contrast our data suggest that symptoms of HAVS do occur, given sufficient exposure, a finding relevant not only to gas supply workers, but also to workers from other industries who break and repair road surfaces. PMID:9930095
Chappelle, Wayne; Goodman, Tanya; Reardon, Laura; Thompson, William
Remotely piloted aircraft (RPA), commonly referred to as "drones," have emerged over the past decade as an innovative warfighting tool. Given there is a paucity of empirical research assessing drone operators, the purpose of this study was to assess for the prevalence of PTSD symptoms among this cohort. Of the 1084 United States Air Force (USAF) drone operators that participated, a total of 4.3% endorsed a pattern of symptoms of moderate to extreme level of severity meeting criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders-4th edition. The incidence of PTSD among USAF drone operators in this study was lower than rates of PTSD (10-18%) among military personnel returning from deployment but higher than incidence rates (less than 1%) of USAF drone operators reported in electronic medical records. Although low PTSD rates may be promising, limitations to this study are discussed. PMID:24907535
Hu, Rong; Li, Yingxue; Zhang, Zhixia; Yan, Weirong
Background The purpose of the study was to investigate the association between depression and/or depressive symptoms during pregnancy and the risk of an operative delivery or preeclampsia, and to quantify the strength of the association. Methods A search of the PubMed, SCI/SSCI, Proquest PsycARTICLES and CINAHL databases was supplemented by manual searches of bibliographies of key retrieved articles and review articles. We aimed to include case control or cohort studies that reported data on antenatal depression and /or depressive symptoms and the risk of an operative delivery and/or preeclampsia. Results Twelve studies with self-reported screening instruments were eligible for inclusion with a total of 8400 participants. Seven articles that contained 4421 total participants reported the risk for an operative delivery, and five articles that contained 3979 total participants reported the risk for preeclampsia. The pooled analyses showed that both operative delivery and preeclampsia had a statistically significant association with antenatal depressive symptoms (RR = 1.24; 95% CI, 1.14 to 1.35, and OR = 1.63, 95% CI, 1.32 to 2.02, respectively). When the pre-pregnancy body mass indices were controlled in their initial design, the risk for preeclampsia still existed (OR = 1.48, 95% CI, 1.04 to 2.01), while the risk for an operative delivery became uncertain (RR = 1.01, 95% CI, 0.85 to 1.22). Conclusions Antenatal depressive symptoms are associated with a moderately increased risk of an operative delivery and preeclampsia. An abnormal pre-pregnancy body mass index may modify this association. PMID:25789626
Jepsen, Jørgen R; Thomsen, Gert
Background The character of upper limb disorder in computer operators is subject to debate. A peripheral nerve-involvement is suggested from the common presence of a triad of symptoms consisting of pain, paraestesiae and subjective weakness, and from physical findings suggesting neuropathy. This study aimed to examine the outcome of a detailed neurological examination in computer operators and to compare findings with the presence of symptoms. Methods 96 graphical computer operators answered a modified Nordic Questionnaire including information on perceived pain in the shoulder, elbow, and wrist/hand scored for each region on a VAS-scale 0 – 9. In addition, they underwent a physical examination including the subjective assessment of the individual function of 11 upper limb muscles, of algesia in five and vibratory threshold in three territories, respectively, and of mechanosensitivity of nerves at seven locations. In order to reflect an involvement of the brachial plexus (chord level), the posterior interosseous nerve and the median nerve at elbow level we defined three patterns of neurological findings illustrating the course of nerves and their innervation. The pain scores summarized for the three upper limb regions (min. = 0, max = 27) in the mouse-operating and contralateral limbs were compared by a Wilcoxon test and the relation to each physical item analyzed by Kendall's rank correlation. The relation of summarized pain to each pattern was studied by application of a test of the trend across ordered groups (patterns). Results Pain, paraestesiae and subjective weakness was reported for 67, 23, and 7 mouse-operating limbs, respectively, with the summarized pain scores exceeding 4 in 33 limbs. Abnormal physical findings were prevalent. The summarized pain was significantly related to a reduced function in five muscles, to mechanical allodynia at one location and to elevated threshold to vibration in two territories. Brachial plexopathy was diagnosed in 9/2, median neuropathy in 13/5 and posterior interosseous neuropathy in 13/8 mouse operating/contralateral limbs, respectively. The summarized pain was significantly higher in the mouse-operating limbs and in limbs with any of the defined patterns. There was a significant trend between the summarized pain and the summarized scores for the items contained in each pattern. Conclusion This small-scale study of a group of computer-operators currently in work and with no or minor upper limb symptoms has indicated in symptomatic subjects the presence of peripheral nerve-afflictions with specific locations. PMID:17078880
;Foto:KnutAasland #12;Hva er produktutvikling og produksjon? Produktutvikling og produksjon (PuP) er et Engineering. Med denne basisen på plass velger du selv hva du vil jobbe videre med. På studieprogrammet lærer
Christensen, Henrik Bærbak
Cloud Computing og availability Projekt i pålidelighed Henrik Lavdal - 20010210 Søren Bardino Kaa - 20011654 Gruppe 8 19-03-2010 #12;Cloud Computing og availability Side 2 af 28 Indholdsfortegnelse ...........................................................................................5 Cloud computing
Masahiro GOTOH; Isao SAITO; Jian HUANG; Yukio FUKAYA; Tadao MATSUMOTO; Naomi HISANAGA; Eiji SHIBATA; Gaku ICHIHARA; Michihiro KAMIJIMA; Yasuhiro TAKEUCHI
Changes in Cholinesterase Activity, Nerve Conduction Velocity, and Clinical Signs and Symptoms in Termite Control Operators Exposed to Chlorpyrifos: Masahiro GOTOH, et al. Asahi Rosai Hospital—We have surveyed periodical medical examinations for pest and termite control operators (n=64) exposed to chlorpyrifos and other organophosphate pesticides. Distribution of serum butyrylcholinesterase (BuChE) activities of all workers ranged 0.01-1.18 (? pH). Serum BuChE
Dianat, Iman; Kord, Madeh; Yahyazade, Parvin; Karimi, Mohammad Ali; Stedmon, Alex W
This cross-sectional study evaluated working conditions and the occurrence of self-reported musculoskeletal symptoms among 251 Iranian sewing machine operators. A questionnaire and direct observations of working postures using the rapid upper limb assessment (RULA) method were used. A high prevalence of musculoskeletal symptoms, particularly in the neck/shoulders, back and hands/wrists were found. The mean RULA grand score of 5.7 highlighted a poor sewing workstation design and indicated that most operators (with posture assessed at action level 3) needed an investigation and changes in their working habits soon. Work-related factors (including number of years worked as an operator, prolonged working hours per shift, long duration of sitting work without a break, feeling pressure due to work and working postures) and individual factors (including age, gender, BMI and regular sport/physical activities) were associated with musculoskeletal symptoms in multiple logistic regression models. The findings add to the understanding of working conditions of those jobs involving sewing activities and emphasise the need for ergonomic interventions to reduce musculoskeletal symptoms in the future. PMID:26154216
Levitt, Alexandra E; Galor, Anat; Weiss, Jayne S; Felix, Elizabeth R; Martin, Eden R; Patin, Dennis J; Sarantopoulos, Konstantinos D; Levitt, Roy C
Laser in-situ keratomileusis (LASIK) is a commonly performed surgical procedure used to correct refractive error. LASIK surgery involves cutting a corneal flap and ablating the stroma underneath, with known damage to corneal nerves. Despite this, the epidemiology of persistent pain and other long-term outcomes after LASIK surgery are not well understood. Available data suggest that approximately 20-55% of patients report persistent eye symptoms (generally regarded as at least 6 months post-operation) after LASIK surgery. While it was initially believed that these symptoms were caused by ocular surface dryness, and referred to as "dry eye," it is now increasingly understood that corneal nerve damage produced by LASIK surgery resembles the pathologic neuroplasticity associated with other forms of persistent post-operative pain. In susceptible patients, these neuropathological changes, including peripheral sensitization, central sensitization, and altered descending modulation, may underlie certain persistent dry eye symptoms after LASIK surgery. This review will focus on the known epidemiology of symptoms after LASIK and discuss mechanisms of persistent post-op pain due to nerve injury that may be relevant to these patients. Potential preventative and treatment options based on approaches used for other forms of persistent post-op pain and their application to LASIK patients are also discussed. Finally, the concept of genetic susceptibility to post-LASIK ocular surface pain is presented. PMID:25896684
Utdanningen har gitt både meg og bedriften kompetanse og forde- ler som vi ellers ikke ville hatt,ogkursetav- sluttes med hjemmeeksamen,sier Ola Strandhagen, professor ved NTNU. Jeg har stort sett tatt ett fag per.Jegplanleggeråstartepåmas- teroppgaven neste semester, sier Mæhlum,som har brukt tre og et halvt år hittil, og regner ett år til
Jepsen, Jorgen R; Thomsen, Gert
Background In a previous study of computer operators we have demonstrated the relation of upper limb pain to individual and patterns of neurological findings (reduced function of muscles, sensory deviations from normal and mechanical allodynia of nerve trunks). The identified patterns were in accordance with neural afflictions at three specific locations (brachial plexus at chord level, posterior interosseous and median nerve on elbow level). We have introduced an intervention program aiming to mobilize nerves at these locations and tested its efficacy. Methods 125 and 59, respectively, computer operators in two divisions of an engineering consultancy company were invited to answer a questionnaire on upper limb symptoms and to undergo a blinded neurological examination. Participants in one division were subsequently instructed to participate in an upper limb stretching course at least three times during workdays in a six month period. Subjects from the other division served as controls. At the end of the intervention both groups were invited to a second identical evaluation by questionnaire and physical examination. Symptoms and findings were studied in the right upper limb. Perceived changes of pain were recorded and individual and patterns of physical findings assessed for both groups at baseline and at follow-up. In subjects with no or minimal preceding pain we additionally studied the relation of incident pain to the summarized findings for parameters contained in the definition of nerve affliction at the three locations. Results Summarized pain was significantly reduced in the intervention group but unchanged in controls. After the intervention, fewer neurological abnormalities in accordance with nerve affliction were recorded for the whole material but no conclusion could be drawn regarding the relation to the intervention of this reduction. Incident pain correlated to findings in accordance with the three locations of nerve affliction. Conclusion A six month course of stretching seems to reduce upper limb symptoms in computer operators but we could not demonstrate an influence on neurological physical findings in this sample. The relation of incident symptoms to identified neurological patterns provides additional support to the construct validity of the employed neurological examination. PMID:18179682
Chappelle, Wayne L; McDonald, Kent D; Prince, Lillian; Goodman, Tanya; Ray-Sannerud, Bobbie N; Thompson, William
The goal of this study is to repeat a survey administered in 2010 to assess for changes in mental health among United States Air Force aircrew operating Predator/Reaper remotely piloted aircraft, also commonly referred to as "drones." Participants were assessed for self-reported sources of occupational stress, levels of clinical distress using the Outcome Questionnaire-45.2, and symptoms of post-traumatic stress disorder (PTSD) using the PTSD Checklist-Military Version. A total of 1,094 aircrew responded to the web-based survey composed of the commercially available standardized instruments mentioned above. The survey also contained nonstandardized items asking participants to report the main sources of their occupational stress, as well as questions addressing demographics and work-related characteristics. The estimated response rate to the survey was 49%. Study results reveal the most problematic self-reported stressors are operational: low manning, extra duties/administrative tasks, rotating shift work, and long hours. The results also reveal 10.72% of operators self-reported experiencing high levels of distress and 1.57% reported high levels of PTSD symptomology. The results are lower than findings from the 2010 survey and from soldiers returning from Iraq and Afghanistan. Implications of the study and recommendations for United States Air Force line leadership and mental health providers are discussed. PMID:25102551
er det viktig å være i mediene? 4 Ta initiativ til mediekontakt! 6 Hva er en nyhet? 8 Journalistens arbeidsvilkår 10 Hva trenger journalisten? 11 Når journalisten besøker UiO 12 Når du skal intervjues 14 Før og prinsipielt interessant. Hva er en nyhet? FOTO:UIO/OLASÆTHER Jørn Hurum ble først intervjuet av verdenspressen
Dosman, James A; Chenard, Liliane; Rennie, Donna C; Senthilselvan, Ambikaipakan
In large commercial swine operations, workers are exposed to indoor air-contaminants during their work-shift. In recently developed large swine operations, exposures are typically 8 or 12 hours/day and females account for a sizeable proportion of the workers. Implications of enhanced exposures and gender require evaluation. Two hundred and forty male and 134 female swine barn workers and 184 male and 227 female nonfarming rural dwellers (controls) (mean age +/- SD males: 36.2 +/- 11.9; females: 34.9 +/- 10.7) completed respiratory questionnaires. Of these, 348 workers (93.0%) and 401 controls (97.6%) underwent allergy skin prick tests (house dust mite, Alternaria sp., hog, cat, mixed grass). The number of hours worked per day was 8.2 for female workers and 7.7 for male workers. Atopy was present in 38.7% and 29.4% of male and female workers, and 46.9% and 38.3% of male and female controls. There was a 72% reduction in risk for chronic phlegm and 70% reduction in usual phlegm in female workers with atopy in comparison to female controls without atopy. There was a significantly increased risk for chronic and usual phlegm, and chronic and usual cough in male workers with atopy. Female workers with atopy were at increased risk for asthma. These findings, that atopy in exposed female workers may be protective of symptoms suggestive of chronic bronchitis but that atopic female workers may be more susceptible to the development of asthma, suggest that exposures to inhaled substances in the workplace may be mediated differently in male and female workers. PMID:19437288
Peng Chen; Toshio Toyota; Zhengja He
Dimensional or nondimensional symptom parameters are usually used for condition monitoring of plant machinery. However, it is difficult to extract the most important symptom parameters and the functions of those parameters by which machinery faults can be sensitively detected and the fault types can be precisely distinguished. In order to overcome this difficulty and to ensure highly accurate fault diagnosis,
Ronaldson, Amy; Poole, Lydia; Kidd, Tara; Leigh, Elizabeth; Jahangiri, Marjan; Steptoe, Andrew
Objective Optimism is thought to be associated with long-term favourable outcomes for patients undergoing coronary artery bypass graft (CABG) surgery. Our objective was to examine the association between optimism and post-operative pain and physical symptoms in CABG patients. Methods We assessed optimism pre-operatively in 197 adults undergoing CABG surgery, and then followed them up 6–8 weeks after the procedure to measure affective pain, pain intensity, and physical symptom reporting directly pertaining to CABG surgery. Results Greater optimism measured pre-operatively was significantly associated with lower pain intensity (? = ? 0.150, CI = ? 0.196 to ? 0.004, p = .042) and fewer physical symptoms following surgery (? = ? 0.287, CI = ? 0.537 to ? 0.036, p = .025), but not with affective pain, after controlling for demographic, clinical and behavioural covariates, including negative affectivity. Conclusions Optimism is a modest, yet significant, predictor of pain intensity and physical symptom reporting after CABG surgery. Having positive expectations may promote better recovery. PMID:25129850
Symptom Management A brain injury can affect a person physically and psychologically, and sometimes the symptoms don't appear ... Diagnosis and Assessment Treatment and Recovery Caregiving Symptom Management Life After TBI Defense and Veterans Brain Injury ...
Renshaw, Keith D; Rodrigues, Camila S; Jones, David H
In current military operations in Iraq and Afghanistan, US National Guard (NG) troops are serving longer deployments than ever before. Little is known, however, about how such deployments affect this population of individuals, relative to active component (AC) troops. This study investigated the extent of combat exposure, severity of post-deployment psychological symptoms, and general interpersonal functioning, as well as the interrelationships of these variables, in 50 NG soldiers who served a 12-month deployment in Iraq from 2005 to 2006. The results indicate that combat exposure and post-deployment post-traumatic stress symptoms in this sample are greater than those in NG veterans of past military operations, and similar to those of full-time soldiers in current operations. Furthermore, the patterns of interrelationships between combat exposure, psychological symptoms, and interpersonal variables were similar to those detected in prior research on AC troops. These results suggest that NG veterans of current military operations may require similar services as active duty veterans. Given that NG troops are less integrated into the military structure, specific outreach efforts may be needed to help NG veterans to receive such services. PMID:18785032
Symptom validity test performance and consistency of self-reported memory functioning of Operation Enduring Freedom/Operation Iraqi freedom veterans with positive Veteran Health Administration Comprehensive Traumatic Brain Injury evaluations.
Russo, Arthur C
Operation Enduring Freedom and Operation Iraqi Freedom combat veterans given definite diagnoses of mild Traumatic Brain Injury (TBI) during the Veteran Health Administration (VHA) Comprehensive TBI evaluation and reporting no post-deployment head injury were examined to assess (a) consistency of self-reported memory impairment and (b) symptom validity test (SVT) performance via a two-part study. Study 1 found that while 49 of 50 veterans reported moderate to very severe memory impairment during the VHA Comprehensive TBI evaluation, only 7 had reported any memory problem at the time of their Department of Defense (DOD) post-deployment health assessment. Study 2 found that of 38 veterans referred for neuropsychological evaluations following a positive VHA Comprehensive TBI evaluation, 68.4% failed the Word Memory Test, a forced choice memory recognition symptom validity task. Together, these studies raise questions concerning the use of veteran symptom self-report for TBI assessments and argue for the inclusion of SVTs and the expanded use of contemporaneous DOD records to improve the diagnostic accuracy of the VHA Comprehensive TBI evaluation. PMID:23059350
LPU OG LEP STUDENTFORENING ARRANGERER FAGKVELD OM MOBBING Sted: Kjeller'n pÃ¥ Helga Eng Dag: Tirsdag Foredragsholder Terje Forsberg vokste opp med grov mobbing pÃ¥ skolen og en alkoholisert og voldelig far. En lÃ¦rer. Mobbing er et vanskelig tema. Her kan vi fÃ¥ hjelp til Ã¥ se hvordan vi som lÃ¦rere kan forebygge mobbing, og
... Submit Home > HIV/AIDS > What is HIV/AIDS? HIV/AIDS This information in Spanish ( en español ) HIV symptoms Photo courtesy of AIDS.gov Facing AIDS ... and brain Return to top More information on HIV symptoms Explore other publications and websites Basic Information ...
W. M. Rowston; S. E. McCluskey; J. C. Gazet; J. Hubert Lacey; G. Franks; D. Lynch
Sixteen morbidly obese patients (12 females, four males) underwent the Scopinaro operation according to Gazet. Profound weight\\u000a loss occurred, along with marked improvements in eating patterns, mood and psychosocial functioning which were reported retrospectively\\u000a 1 year and repeated 2 years after surgery. Continued binge eating, comfort eating and ‘eating sensibly\\/making up in private’\\u000a were associated with reduced weight loss, suggesting
electrolysis of steam Solid Oxide Electrolyser Cell Dansk Selskab for Vindenergi, Ebeltoft, okt. 2004 - Allan Schrøder P. #12;Produktion og lagring af brint Thermodynamics of electrolysis of steam Graph taken from E Central Receiver System and High Temperature Electrolysis of Steam", in Proceedings of the Third
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skal det skrives litt om hva diusjonsprosesser er, hvilke spesielle resultater fra diusjonsteorien man skal se nærmere på i oppgaven, og hva som menes med diusjonstilnærmelse. De teoretiske resultatene sammenliknes med de resultatene man nner ved å benytte diusjonstilnærmelsen. Prøv å nne ut hva som skal til
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Brodal, Gerth StÃ¸lting
grafens knuder svarer til webÂsiderne og hvor der findes en kant fra en knude u til en knude v hvis og kun i opgaven. Vi antager i det fÃ¸lgende at grafen er givet ved adjacency list reprÃ¦sentationen og at der som sÃ¦dvanligt er henholdsvis n knuder og m kanter i grafen. LÃ¦ngden af en sti i grafen er som
Pesaresi, D.; Barnaba, C.
The Centro di Ricerche Sismologiche (CRS, Seismological Research Centre) of the Istituto Nazionale di Oceanografia e di Geofisica Sperimentale (OGS, Italian National Institute for Oceanography and Experimental Geophysics) in Udine (Italy) after the strong earthquake of magnitude M=6.4 occurred in 1976 in the Italian Friuli-Venezia Giulia region, started to operate the Northeastern Italy Seismic Network: it currently consists of 19 very sensitive broad band and 17 simpler short period seismic stations, all telemetered to and acquired in real time at the OGS CRS data centre in Udine. The southwestern edge of the OGS seismic network stands on the Po alluvial basin: earthquake localization and characterization in this area is affected by the presence of soft alluvial deposits. Following the ML=5.9 earthquake that struck the Emilia region around Ferrara in Northern Italy on May 20, 2012, a cooperation of Istituto Nazionale di Geofisica e Vulcanologia, OGS, the Comune di Ferrara and the University of Ferrara lead to the reinstallation of a previously existing very broad band (VBB) borehole seismic station in Ferrara and to the deployment of a temporary seismographic network consisting of eight portable seismological stations, to record the local earthquakes that occurred during the seismic sequence. The aim of the OGS intervention was on one hand to extend its real time seismic monitoring capabilities toward South-West, including Ferrara and its surroundings, and on the other hand to evaluate seismic site responses in the area. We will introduce details of the Ferrara VBB borehole station and the OGS temporary seismographic network configuration and installation. We will then illustrate the location capability performances, and finally we will shortly describe seismic site characterization with surface/borehole comparisons in terms of seismic noise, site amplification and resonance frequencies.
kraftige maskiner basert p°a digital teknologi. I denne artikkelen skal vi snakke litt om hva kompleksitetsklasser er for noe, hva som kjennetegner NP og litt om konsekvensene av at NP-problemer i praksis er mer vanlig formulering av den handelsreisendes problem er Hva er den korteste reisestrekningen vi
deres sensornettverk se ut? Â Hvilke data vil gÃ¥ i disse nettverkene? Â Hvor kan det legges kabler Â hva mÃ¥ vÃ¦re trÃ¥dlÃ¸st? Â Hvilket utstyr skal overvÃ¥kes? Â Hvilke situasjoner kan oppstÃ¥ og hva skal gjÃ¸res
Reimbursement Request OGS Research and Presentation Grants Name for a grant to conduct research, you cannot use the money to go to a conference. Reimbursement requests firstname.lastname@example.org. The grant does not reimburse membership fees or any extra-curricular activities during your conference
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Naumov, Dmitri; Bilke, Lars; Fischer, Thomas; Rink, Karsten; Wang, Wenqing; Watanabe, Norihiro; Kolditz, Olaf
OpenGeoSys (OGS) is a scientific open-source initiative for numerical simulation of thermo-hydro-mechanical/chemical (THMC) processes in porous and fractured media, continuously developed since the mid-eighties. The basic concept is to provide a flexible numerical framework for solving coupled multi-field problems. OGS is targeting mainly on applications in environmental geoscience, e.g. in the fields of contaminant hydrology, water resources management, waste deposits, or geothermal energy systems, but it has also been successfully applied to new topics in energy storage recently. OGS is actively participating several international benchmarking initiatives, e.g. DECOVALEX (waste management), CO2BENCH (CO2 storage and sequestration), SeSBENCH (reactive transport processes) and HM-Intercomp (coupled hydrosystems). Despite the broad applicability of OGS in geo-, hydro- and energy-sciences, several shortcomings became obvious concerning the computational efficiency as well as the code structure became too sophisticated for further efficient development. OGS-5 was designed for object-oriented FEM applications. However, in many multi-field problems a certain flexibility of tailored numerical schemes is essential. Therefore, a new concept was designed to overcome existing bottlenecks. The paradigms for ogs6 are: - Flexibility of numerical schemes (FEM#FVM#FDM), - Computational efficiency (PetaScale ready), - Developer- and user-friendly. ogs6 has a module-oriented architecture based on thematic libraries (e.g. MeshLib, NumLib) on the large scale and uses object-oriented approach for the small scale interfaces. Usage of a linear algebra library (Eigen3) for the mathematical operations together with the ISO C++11 standard increases the expressiveness of the code and makes it more developer-friendly. The new C++ standard also makes the template meta-programming technique code used for compile-time optimizations more compact. We have transitioned the main code development to the GitHub code hosting system (https://github.com/ufz/ogs). The very flexible revision control system Git in combination with issue tracking, developer feedback and the code review options improve the code quality and the development process in general. The continuous testing procedure of the benchmarks as it was established for OGS-5 is maintained. Additionally unit testing, which is automatically triggered by any code changes, is executed by two continuous integration frameworks (Jenkins CI, Travis CI) which build and test the code on different operating systems (Windows, Linux, Mac OS), in multiple configurations and with different compilers (GCC, Clang, Visual Studio). To improve the testing possibilities further, XML based file input formats are introduced helping with automatic validation of the user contributed benchmarks. The first ogs6 prototype version 6.0.1 has been implemented for solving generic elliptic problems. Next steps are envisaged to transient, non-linear and coupled problems. Literature:  Kolditz O, Shao H, Wang W, Bauer S (eds) (2014): Thermo-Hydro-Mechanical-Chemical Processes in Fractured Porous Media: Modelling and Benchmarking - Closed Form Solutions. In: Terrestrial Environmental Sciences, Vol. 1, Springer, Heidelberg, ISBN 978-3-319-11893-2, 315pp. http://www.springer.com/earth+sciences+and+geography/geology/book/978-3-319-11893-2  Naumov D (2015): Computational Fluid Dynamics in Unconsolidated Sediments: Model Generation and Discrete Flow Simulations, PhD thesis, Technische Universität Dresden.
Anna Jensen, DTU Side 1 August 2004 ITRF, ETRS, EUREF89 og WGS84 - hvad er det nu lige det er? Anna ITRF, ETRS, EUREF89 og WGS84 nÃ¦sten det samme, og hvis man arbejder med absolut GPS, og er tilfreds med amerikansk udviklede WGS84 og dets relation til de Ã¸vrige systemer, og til sidst kommer nogle bemÃ¦rkning om
Badheka, Apurva O; Chothani, Ankit; Panaich, Sidakpal S; Mehta, Kathan; Patel, Nileshkumar J; Deshmukh, Abhishek; Singh, Vikas; Arora, Shilpkumar; Patel, Nilay; Grover, Peeyush; Shah, Neeraj; Savani, Chirag N; Patel, Achint; Panchal, Vinaykumar; Brown, Michael; Kaki, Amir; Kondur, Ashok; Mohamad, Tamam; Elder, Mahir; Grines, Cindy; Schreiber, Theodore
The increase in the number of carotid artery stenting (CAS) procedures over the last decade has necessitated critical appraisal of procedural outcomes and patterns of utilization including cost analysis. The main objectives of our study were to evaluate the postprocedural mortality and complications after CAS and the patterns of resource utilization in terms of length of stay (LOS) and cost of hospitalization. We queried the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample from 2006 to 2010 using the International Classification of Diseases, Ninth Revision, procedure code of 00.63 for CAS. Hierarchical mixed-effects models were generated to identify the independent multivariate predictors of in-hospital mortality, procedural complications, LOS, and cost of hospitalization. A total of 13,564 CAS procedures (weighted n = 67,344) were analyzed. The overall postprocedural mortality was low at 0.5%, whereas the complication rate was 8%, both of which remained relatively steady over the time frame of the study. Greater postoperative mortality and complications were noted in symptomatic patients, women, and those with greater burden of baseline co-morbidities. A greater operator volume was associated with a lower rate of postoperative mortality and complications, as well as shorter LOS and lesser hospitalization costs. In conclusion, the postprocedural mortality after CAS has remained low over the recent years. Operator volume is an important predictor of postprocedural outcomes and resource utilization. PMID:25208563
Brodal, Gerth StÃ¸lting
Â°a internettet. Siderne kan opfattes som en orienteret graf, hvor grafens knuder svarer til web-siderne og hvor at grafen er givet ved adjacency list reprÃ¦sentationen og at der som sÃ¦dvanligt er henholdsvis n knuder og m kanter i grafen. LÃ¦ngden af en sti i grafen er som sÃ¦dvanligt antallet af kanter der indgÂ°ar i stien
Huijie Ji; Meihua Xu; Feng Ran
A scheme for auto classification of skin symptom is introduced in this paper. It classifies different skin symptoms based on the principle of least Mahalanobis distance. Skin images with symptom to be identified will be preprocessed at first. Basic operations of preprocessing includes color space transformation, image segmentation based on threshold by self-adapting method, image post-processing by mathematical morphology, edge
... of the American Medical Association JAMA PATIENT PAGE Vaginal Symptoms V aginal symptoms are one of the ... includes an article about diagnosing vaginal symptoms. DIAGNOSING VAGINAL SYMPTOMS FOR MORE INFORMATION • American College of Obstetricians ...
Swarnjit Singh; Joel E. Richter; Laurence A. Bradley; Julie M. Haile
The symptom index is a quantitative measure developed for assessing the relationship between gastroesophageal reflux and symptoms. Controversy exists, however, over its accuracy and the appropriate threshold for defining acid-related symptoms of heartburn and chest pain. Therefore, a retrospective review was done of 153 consecutive patients referred to our esophageal laboratory. Three groups were identified: patients with normal 24-hr pH
... My Bridge 4 Life Clinical Trials Guides Newsletters Nutrition & Wellness PCF Spotlight Glossary African American Men Understanding Prostate Cancer Prostate Cancer Symptoms English | Español Not everyone experiences ...
LENA FJELDHEIM GOURSAUD - TEKST OG FOTO Marianne Espeland fra Kydland skal i tre år forske på Salomonøyene (foto: privat). Under feltarbeidet treffer Marianne på mange ulike og flotte insekter. Her to fargerike øyenstikkere på Salomonøyene (foto: privat). Marianne har alltid med seg lokale hjelpere. Her er
Carbonate Fuel Cell", MCFC) og endelig fastoxidbrændselscellen (eng. "Solid Oxide Fuel Cell", SOFC), som har brændselscelle, der er tale om. I det følgendebetragter vi en SOFC, men princip- pet er det samme for de andre typer: De iltioner, der dannes p°a katodesiden af SOFC-cellen, vil forbruges p°a anodesiden
at være blandt de absolut førende i verden inden for SOFC-teknologien. Aftalen forpligter Risø til fem års forskning og udvikling af SOFC-brændselscel- ler, er positiv for Risø og Risøs forskere såvel for Materialeforskning som i dag arbejder med forskning og udvikling af SOFC-brændselsceller. Han er programleder og ved
2D og 3D invers Radon transformation til PET Jesper James Jensen Frembringelse og tolkning af PET optaget med PET skannere ved hjaelp af den inverse Radon transformation. Der eksisterer forskellige Radon transformation til PET og Frembringelse og tolkning af PET billeder. Disse projekter er udfÃ¸rt i
This article considers the relationship between various types of dissociative symptoms, including symptoms of depersonalization, derealization, and conversion disorders, and epilepsy. After introductory remarks concerning dissociation, this relationship is discussed through two main themes: firstly, the phenomenology and mechanisms of so-called 'dreamy states' in epilepsy and their closest analogs in psychiatric disorders, and secondly, the similarities and differences between epileptic seizures and psychogenic nonepileptic attacks. Although epileptic and dissociative symptoms may appear similar to observers, they arise through different mechanisms and have different experiential qualities. PMID:24196397
... Home What Are the Symptoms of Ovarian Cancer? Language: English Español (Spanish) Recommend on Facebook Tweet Share Compartir ... Should I Know About Screening? Â Stay Informed Language: English Español (Spanish) File Formats Help: How do I ...
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Acute and chronic intoxications become manifest in primary neurological symptoms. After a definition of poisoning the autonomic, neurological and psychological disturbances are briefly discussed and the therapeutic measures presented in a table. Later, the neurological symptoms are described with reference to oberservations of cases of lead, thallium, E 605 (parathion), carbon monoxide, mercury, amphetamine and botulin poisoning. Four table and 9 figures supplement the text. PMID:6775212
... treatments A - D Contact dermatitis Signs and symptoms Contact dermatitis: Signs and symptoms Allergic contact dermatitis : Testing ... these symptoms, you need immediate medical care. Allergic contact dermatitis This skin condition occurs when you have ...
David B. Burnett; Mustafa Siddiqui
Management and disposal of produced water is one of the most important problems associated with oil and gas (O&G) production. O&G production operations generate large volumes of brine water along with the petroleum resource. Currently, produced water is treated as a waste and is not available for any beneficial purposes for the communities where oil and gas is produced. Produced
Miyashita, K; Morioka, I; Tanabe, T; Iwata, H; Takeda, S
To study the effects of construction machinery operation on subjective symptoms, a questionnaire survey was carried out among construction machinery operators by a self-reporting method. Subjects were 184 power shovel operators, 127 bulldozer operators, 44 forklift operators as operator groups, and 44 office workers as a control. Their ages were in a range of 30-49 years. The questionnaire contained 20 symptoms referring to fatigue, digestive problems, and upper or lower limbs or back problems. The prevalence rate and symptom characteristics were examined. The dominant symptoms of the operator groups were stiff shoulder, low back pain, and stomach symptoms. The prevalence rate of low back pain was significantly different between forklift operators and controls. No significant differences were found in the symptoms of upper limbs and fingers between operator groups and controls. The prevalence of Raynaud's phenomenon was 0.5%-2.3% in the operator groups and 2.3% in the control group. PMID:1487332
Barbanti, Piero; Fofi, L; Aurilia, C; Egeo, G
Migraine pain is often preceded, accompanied and followed by dopaminergic symptoms (premonitory yawning and somnolence, accompanying nausea and vomiting, postdromal somnolence, euphoria and polyuria). After reviewing evidence from pharmacological, biochemical, genetic and animal experimental studies on the relationship between dopamine and migraine, and matching these data with patients' clinical features, we postulate that migraine attacks could be characterized by an ictal dopamine release in a subject with dopamine receptor hypersensitivity due to a chronic dopaminergic deficit synergistic to serotoninergic impairment. Our review suggests that when the attack begins, a low dopamine plasma concentration stimulates hypersensitive central presynaptic dopamine receptors thus causing prodromal symptoms such as yawning and somnolence. Increasing dopamine levels, though still insufficient to stop trigeminovascular activation, stimulate postsynaptic dopamine receptors thus inducing nausea, vomiting and hypotension. Finally, dopamine levels slowly return to baseline, giving rise to somnolence and fatigue, but, in some cases, continue to rise triggering postdromal symptoms such as euphoria and polyuria. PMID:23695049
Krishnan, Jerry A.; Lemanske, Robert F.; Canino, Glorisa J.; Elward, Kurtis S.; Kattan, Meyer; Matsui, Elizabeth C.; Mitchell, Herman; Sutherland, E. Rand; Minnicozzi, Michael
Background Respiratory symptoms are commonly used to assess the impact of patient-centered interventions. Objective At the request of National Institutes of Health (NIH) institutes and other federal agencies, an expert group was convened to propose which measurements of asthma symptoms should be used as a standardized measure in future clinical research studies. Methods Asthma symptom instruments were classified as daily diaries (prospectively recording symptoms between research visits) or retrospective questionnaires (completed at research visits). We conducted a systematic search in PubMed and a search for articles that cited key studies describing development of instruments. We classified outcome instruments as either core (required in future studies), supplemental (used according to study aims and standardized), or emerging (requiring validation and standardization). This work was discussed at an NIH-organized workshop in March 2010 and finalized in September 2011. Results Four instruments (3 daily diaries, 1 for adults and 2 for children; and 1 retrospective questionnaire for adults) were identified. Minimal clinically important differences have not been established for these instruments, and validation studies were only conducted in a limited number of patient populations. Validity of existing instruments may not be generalizable across racial-ethnic or other subgroups. Conclusions An evaluation of symptoms should be a core asthma outcome measure in clinical research. However, available instruments have limitations that preclude selection of a core instrument. The working group participants propose validation studies in diverse populations, comparisons of diaries versus retrospective questionnaires, and evaluations of symptom assessment alone versus composite scores of asthma control. PMID:22386505
... variable from one person to another. Although the mean survival time with ALS is three to five years, many people live five, 10 or more years. Symptoms can begin in the muscles that control speech and swallowing or in the hands, arms, ...
... materials (aspiration pneumonia) Breathing difficulty, possibly leading to death (10-20% of cases are fatal) Â Top of Page Related Page Symptoms/Complications for Clinicians Related Links Tetanus Vaccination Maternal and Neonatal Tetanus Elimination File Formats Help: How do I ...
Idsoe, Thormod; Dyregrov, Atle; Idsoe, Ella Cosmovici
PTSD symptoms related to school bullying have rarely been investigated, and never in national samples. We used data from a national survey to investigate this among students from grades 8 and 9 (n = 963). The prevalence estimates of exposure to bullying were within the range of earlier research findings. Multinomial logistic regression showed that…
Coppo, Peter; Chiarantini, Leandro; Maselli, Fabio; Migliorini, Stefano; Pippi, Ivan; Marcoionni, Paolo
The Officine Galileo (OG) Hyperspectral Camera (HYC) (currently under development in the frame of the Hypseo ASI program) consists of an high spatial resolution (20 m) imaging spectrometer working in the visible and SWIR bands, to be embarked on future low earth orbit operational satellites. The mission requirements include monitoring of vegetation, coastal/internal waters and geology/hydrology. The instrument works with a swath of 20 Km and steering capability within 500-Km across-track. It operates in about 210 spectral bands of 10 nm of resolution. The objective of the present work is the evaluation of application performances of the HYC camera compared to those of multi- spectral sensors (e.g. ETM+/Landsat 7), carried out by means of images and products simulations. For this scope some airborne campaigns have been performed with hyper- spectral sensors (VIRS, MIVIS) in a test area of Tuscany region (1), with contemporaneous collection of ground/sea truth data. HYC and ETM+ radiance images have been simulated by means of surface reflectance maps obtained from the airborne sensors, applying the MODTRAN atmospheric code and the HYC (and ETM+) instrumental models (spatial, spectral and noise degradation). The retrieval of surface reflectance has been performed by means of an atmospheric correction algorithm based on the dark pixel method. Next, two test products (forest classification and river plumes analysis) have been simulated; the first based on a maximum likelihood classification method and the second based on multivariate regression analysis. The results have been validated with ground truth data for different atmospheric conditions. Classification error decreases from 22% (ETM+) to 13% (HYC), whereas suspended sediments accuracy error decreases from 24% (ETM+) to 15% (HYC) in the tested conditions. The implemented methodology has allowed studying the better trade-off between product accuracy and instrumental requirements.
overflader er lige så vigtige i mange anvendelser udenfor kroppen. Nogle eksempler er DNA-chips og pro biokompatible overflader skærpes yderligere, hvis vi prø- ver at få stamceller til at gro, specialisere sig og
energianvendelse En målrettet dansk forskning og udvikling i magnetiske gear kan på længere sigt bane vej for dansk konstruktion. Desuden bør der arbejdes med integration af mag- netgear og elektrisk maskine, der kan bane vej
Mo, K.; Lee, S. J.; Seong, P. H. [Dept. of Nuclear and Quantum Engineering, Korea Advanced Inst. of Science and Technology, 373-1, Guseong-dong, Yuseong-gu, Daejeon, 305-701 (Korea, Republic of)
In this study, an operation guidance system (OGS) has been developed to regulate and supervise operators' actions during abnormal environments in nuclear power plants (NPPs). The system integrated a primitive computerized procedures system (CPS) and an operation validation system (OVS). As the key component of the OGS, OVS provides two important functions for the operators: validated check of operations, and qualitative and quantitative effects analysis of operations. Each of operators' action is evaluated by the system and possible results are simulated by using artificial neural networks (ANNs). Finally, corresponding suggestion or warning is provided to operators. The human errors during operation in emergency could be effectively reduced. (authors)
Design og konstruktion af magnetiske gear ELFOR PSO 334-031 1 #12;Design og konstruktion af magnetiske gear ELFOR PSO 334-031 Projektet er udarbejdet af: Peter Omand Rasmussen Aalborg Universitet opnået i forskningsprojektet Design og konstruktion af magnetiske gear. Projektet er gennemført med PSO
... dementia occurs before or within 1 year of Parkinson's symptoms are diagnosed with DLB. People who have an ... include sound, taste, smell, and touch. Parkinsonism or Parkinson's Disease symptoms, take the form of changes in gait; the ...
Cempel, C.; Natke, H. G.; Yao, J. T. P.
Quite recently the authors of this paper defined the concept of symptom reliability for systems in use or in operation, which means that the reliability is based on symptoms of the systems under consideration. This symptom-dependent reliability is quite different from the commonly known lifetime-based reliability. But despite the lack of definition it is a quantity already used in the practice of machine condition monitoring . Following this concept, the symptom-dependent hazard functions are introduced, and proposals are made for their use. This provides the opportunity to link the symptom reliability with other covariates associated with the systems usuage, such as load and maintenance quality, which are not contained explicitly within the symptom values or lifetimes. This will allow condition determination and prediction to be made more reliably and accurately, and it will make systems usage more economical than before.
Sandilyan, Malarvizhi Babu; Dening, Tom
The clinical features of dementia are usually considered in two groups: cognitive and non-cognitive symptoms. Among cognitive symptoms, problems with memory are typical of most forms of dementia, but problems with language and executive functioning are also prevalent. Non-cognitive symptoms is a somewhat unsatisfactory general term for a group of problems that include mood disorders, psychotic symptoms and various other changes in behaviour. In assessment and management, it is important to look for underlying causes of symptoms and try to understand the perspective of the individual with dementia, because their behaviour may be communicating an important message. PMID:26058652
Aarsland, D.; Marsh, L.; Schrag, A.
Neuropsychiatric symptoms are common in Parkinson's disease, even at the earliest stages, and have important consequences for quality of life and daily functioning, are associated with increased carer burden and increased risk for nursing home admission. In addition to cognitive impairment, a wide range of neuropsychiatric symptoms have been reported. In this paper, the epidemiology, clinical course, diagnosis, and management of some of the most common neuropsychiatric symptoms in PD are discussed: depression, anxiety, apathy, fatigue and psychotic symptoms. Although much is known regarding the prevalence and course of these symptoms, the empirical evidence for how to manage these symptoms is limited at best. There is thus an urgent need for systematic studies for the pharmacological and non-pharmacological management of these symptoms. PMID:19768724
muligheter til Ã¥ fÃ¥ utlÃ¸p for "kunstneriske" tendenser. Kverna maler jevnt og trutt... #12;3 "Ehh... Hva blir lÃ¸sninger nÃ¥r nye problemer skal lÃ¸ses. #12;4 "Jaha... Men hva slags problemer skal jeg lÃ¸se???" Du skal
Oberly, Stacey Inez (Wachimamachi [Antelope Woman])
Describes the Pinunuuchi Po'og'ani, the Southern Ute Indian Academy, providing Montessori education for Southern Ute tribal members ages 6 weeks through 10 years and reviving the use of the Southern Ute language and culture among young students and their families. Describes how the program supports families, students, and staff, and incorporates…
The label "sick building syndrome" is often used to imply the absence of a physiologic basis for symptoms in the built environment. Although building-related illness is widely recognized but considered rare, several well-studied mechanisms may be responsible for many symptoms in buildings. These mechanisms do not explain why some individuals perceive disability. Until researchers distinguish physiologic mechanisms from other aspects of disease and study them systematically, poorly defined symptoms will remain poorly understood. The disability associated with such symptoms and syndromes, not the physiology, is the primary interest and generates controversy. PMID:12194903
PORTLAND STATE UNIVERSITY PLEASE SUBMIT A SINGLE COPY 1/08 OGS This form is available on our website: www.gsr.pdx.edu/ogs.php Overload Approval OVERLOAD APPROVAL The Office of Graduate Studies the approval signatures indicated below in order to register for more than 16 credits in a term (graduate
PORTLAND STATE UNIVERSITY PLEASE SUBMIT A SINGLE COPY 1/11 OGS This form is available on our website: www.gsr.pdx.edu/ogs.php Overload Approval OVERLOAD APPROVAL The Office of Graduate Studies the approval signatures indicated below in order to register for more than 16 credits in a term (graduate
K. Miyashita; I. Morioka; T. Tanabe; H. Iwata; S. Takeda
Summary To study the effects of construction machinery operation on subjective symptoms, a questionnaire survey was caried out among construction machinery operators by a self-reporting method. Subjects were 184 power shovel operators, 127 bulldozer operators, 44 forklift operators as operator groups, and 44 office workers as a control. Their ages were in a range of 30–49 years. The questionnaire contained
Bandettini, Peter A.
1 " " Know the symptoms. Take action. heart attack c a l l Don't Take a Chance With a Heart Attack: Know the Facts and Act Fast More than 1 million people in the United States have heart attacks each attack happens, delay in treatment can be deadly. Learn the warning symptoms of a heart attack, and know
Bandettini, Peter A.
heart attack Know the symptoms. Take action. c a l l Important Information Fill out the next two:____________________________ Home phone:_______________________ Work phone: ________________________ December 2011 #12;Heart Attack might be having heart attack symptoms or a heart attack, call 911 immediately. Don't ignore your pain
Brodal, Gerth StÃ¸lting
graf best#23;aende af k sammen- h#26;ngende #12;rkanter. For k = 12 ser grafen s#23;adan ud: Sp#28;rgsm at #12;nde et minimum udsp#26;ndende tr#26; for grafen. Sp#28;rgsm#23;al b: Beskriv en O(n) algoritme for algoritmens komplek- sitet, og for, at den #12;nder det #28;nskede. Antag at grafen som s#26;dvanligt er givet
Hall, Devin; Finger, Elizabeth C
Although psychotic features have long been recognized in association with frontotemporal dementia (FTD), recent genetic discoveries enabling further subtyping of FTD have revealed that psychotic symptoms are frequent in some forms of FTD. Hallucinations and delusions can even precede onset of other cognitive or behavioural symptoms in patients with FTD. In this review, we explore the frequency and types of psychotic symptoms reported in patients with FTD, as well as in other neuropsychiatric disorders, to aid practitioners' consideration of these features in the diagnosis of FTD and related disorders. PMID:26008815
... nervousness and irritability are signs that a person's blood sugar is getting dangerously low. A person showing any of these symptoms should check their blood sugar. If the level is low (70 mg/dl), ...
... More information on menopause symptom relief and treatments Learning about menopause treatment options Most women do not ... medicine, and blood pressure medicine. Try taking slow, deep breaths when a flash starts. If you’re ...
... Manual Manual Appendices References & Resources Multimedia Related Links Medline Plus Healthfinder.gov Shingles Signs & Symptoms Language: English ... of Page Related Page Chickenpox Complications Related Links Medline Plus Healthfinder.gov Shingles Language: English Español (Spanish) ...
... and Resources MMWR Articles Outbreak Articles Related Links World Health Organization Medline Plus Signs & Symptoms of Mumps Language: English ... Action Coalition's website (www.vaccineinformation.org). Related Links World Health Organization Medline Plus Language: English Español (Spanish) File Formats ...
Tower, R B; Kasl, S V
Data from the Established Populations for the Epidemiologic Study of the Elderly (EPESE) in New Haven include independent interviews with husbands and wives in 317 community-dwelling older couples. Drawing on these data, we (a) describe the prevalence of three aspects of marital closeness: having a confidant, perceived emotional support, and reciprocity between spouses' reports of marital closeness; (b) evaluate their associations with depressive symptoms according to both a respondent's own and his or her spouse's reports; and (c) examine gender similarities and differences in the prevalence and the associations of the closeness variables. Both husbands and wives responded more strongly to their spouse's than to their own. Different dynamics operate, with husbands having fewest depressive symptoms when they have emotionally independent wives, and wives having low levels when they feel important emotionally to their husbands. Dyadic closeness was associated with fewer symptoms in wives and more symptoms in husbands. PMID:8620352
1 Ti år efter Tjernobyl - myter og fakta Den 26. april 1986 skete der en voldsom eks- plosion på Tjernobyl-atomkraftværket i Ukraine. I løbet af de næste ti dage blev der frigjort store mængder af meste er stærkt overdrevet og ofte groft fordrejet. I de ti år, der nu er forløbet siden uheldet, er der
Slutrapport for PSO 337-068 Udvikling af LED lyskilder og lamper Carsten Dam-Hansen, Paul Michael Munkgaard Andersen, Hans Falleboe, Jesper Olsen og Christian Flindt Titel: Slutrapport for PSO 337 light sources and lamps" PSO no. 337-068 supported by Dansk Energi Net. The project
Tsien, Roger Y.
OGS TA LOAN PROGRAM (available Fall quarter only) Application/Payment Agreement 2013/14 Submit: __________________________________ Payroll ID # (if previously employed) _____________ OGS TA LOAN PROGRAM Important: A student must be enrolled before the check can be processed. The TA loan fund provides Teaching Assistants with a loan
OGS TA LOAN PROGRAM (available Fall quarter only) Application/Payment Agreement 2014/15 Submit: __________________________________ Payroll ID # (if previously employed) _____________ OGS TA LOAN PROGRAM Important: A student must be enrolled before the check can be processed. The TA loan fund provides Teaching Assistants with a loan
Indledning Hedehøgen Circus pygargus har siden 1997 været på den danske Rødliste, som omfatter artikel vil vi undersøge hvilke påvirkninger, der har haft indflydelse på artens ungeproduktion, og dermed begyndelsen af 1990erne opda- gede man de første reder i marker med vintersæd, og siden har en stigende andel
Selv om fremstilling og bearbejdning af metaller har været kendt helt tilbage fra jernalderen, har påvirkninger som fx tryk og varme. Nu har for- skerne et redskab til at kigge ind i selve metallets Gitte Willumsen RISØNYT N O 12003 GRUNDFORSKNING ER VIGTIG #12;Metaller har været kendt i mange tusinder
Zhou, XueZhong; Menche, Jörg; Barabási, Albert-László; Sharma, Amitabh
In the post-genomic era, the elucidation of the relationship between the molecular origins of diseases and their resulting phenotypes is a crucial task for medical research. Here, we use a large-scale biomedical literature database to construct a symptom-based human disease network and investigate the connection between clinical manifestations of diseases and their underlying molecular interactions. We find that the symptom-based similarity of two diseases correlates strongly with the number of shared genetic associations and the extent to which their associated proteins interact. Moreover, the diversity of the clinical manifestations of a disease can be related to the connectivity patterns of the underlying protein interaction network. The comprehensive, high-quality map of disease-symptom relations can further be used as a resource helping to address important questions in the field of systems medicine, for example, the identification of unexpected associations between diseases, disease etiology research or drug design. PMID:24967666
Vår beskrivelse av bevegelser og deformasjon av Jordens ytterste skall har i løpet av et århundre). Platetektonikk har hatt suksess, både teoretisk og praktisk, og den har dannet et vitenskapelig rammeverk for en millioner år siden. Senere har geologene kartlagt noen av disse glasiale avsetningene nær ekvator, og han
Gideon E. Anholt; Danielle C. Cath; Patricia van Oppen; Merijn Eikelenboom; Johannes H. Smit; Harold van Megen
In obsessive-compulsive disorder (OCD), the relationship between autism spectrum disorders (ASD), attention-deficit\\/hyperactivity\\u000a disorder (ADHD) symptom, and obsessive-compulsive (OC) symptom dimensions and severity has scarcely been studied. Therefore,\\u000a 109 adult outpatients with primary OCD were compared to 87 healthy controls on OC, ADHD and ASD symptoms. OCD patients showed\\u000a increased ADHD and autism symptom frequencies, OCD + ADHD patients reporting more autism symptoms
Robe, L B; Gromisch, D S; Iosub, S
Neonatal withdrawal symptoms in 15 cases of fetal alcohol syndrome with maternal intoxication at time of delivery, reported in 9 studies, are compared with symptoms reported in 138 cases of neonatal narcotic withdrawal. Seen frequently in ethanol but rarely in narcotic withdrawal are abdominal distention and opisthotonos. Seen frequently in narcotic but rarely in ethanol withdrawal are high pitch cry, frequent yawning, excessive sucking, mottling of the skin, excoriation, nasal stuffiness, excess sweating, sleeplessness and diarrhea. Seen frequently in both are increased muscle tonicity and tremors; however, convulsions are rare in narcotic yet are fairly frequent in neonatal ethanol withdrawal. PMID:7343193
Cheng, Jun; Wang, Lixia; Zhang, Hui; Xia, Yinyin
Objective To evaluate the diagnostic value of symptom screening for tuberculosis (TB) case finding defined in National Tuberculosis Control Program in China (China NTP) among elderly people(?65 years) and younger people(<65 years). Methods We made a secondary analysis in a population-based TB prevalence survey in China in 2010. Questionnaire including information for cough and haemoptysis was completed by face to face interview, and then chest radiography was conducted in all eligible participants. Sputum smear and culture were followed for all TB suspects. We calculated the odds ratios (OR), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and the area under the receiver operating characteristic curve (AUC) of using different symptoms for screening to detect bacteriologically positive TB in subpopulations stratified by age 65, to evaluate the performance of symptom screening for TB. Findings Of 315 newly diagnosed bacteriologically positive TB, 131 patients (41.59%) were elderly, and 48.57% of TB patients were asymptomatic. Nearly 50% patients did not present cough of any duration, and less than half present cough more than 2 weeks, a defined suspected symptom in China NTP. Cough of any duration was reported more in patients aged under 65 than those in elderly, especially for the acute cough (9.78% vs 6.87%). Those symptoms defined by China NTP were reported by less than half participants in two subpopulations. Acute cough (<2 weeks) was an independent predictor of TB in people aged under 65 (adjusted OR: 3.3, 95% CI: 2.0-5.5), but not in those aged 65 and above (adjusted OR: 1.4, 95% CI: 0.7-2.9). The specificity for each symptom was significantly higher in participants aged under 65 (P<0.01), and sensitivities of most symptoms were significantly higher among elderly (P<0.05 or P<0.01). When compared with cough for 2 weeks and more, using cough of any duration for symptom screening increased the sensitivity from 42.9% to 51. % for all participants, and the AUC increased from 0.70 to 0.74 for participants aged under 65 without significant difference. Conclusions There is a high percent of asymptomatic TB patients, and those symptoms adopted in China NTP for screening is poorly predictive for TB. The presence of TB symptoms, the sensitivities and specificities of symptoms for TB were distinct between two subpopulations cut by age 65, implying different case finding strategies should be established for them. The current case finding strategy should be improved, and further studies should be done to evaluate the performance and cost-effectiveness of different symptom screening strategy. PMID:26001190
Emma Haycraft; Jackie Blissett
This study aimed to examine associations between symptoms of eating disorders and parenting style, in a non-clinical sample. One hundred and five mothers completed self-report measures of eating disorder symptoms and parenting style. Higher levels of eating disorder symptoms were associated with more authoritarian and permissive parenting styles. Authoritative parenting was not significantly related to eating disorder symptoms. The findings
Department of the Interior Strategic Science Group
Hurricane Sandy made US landfall near Atlantic City, NJ on 29 October 2012, causing 72 direct deaths, displacing thousands of individuals from damaged or destroyed dwellings, and leaving over 8.5 million homes without power across the northeast and mid-Atlantic. To coordinate federal rebuilding activities in the affected region, the President established the cabinet-level Hurricane Sandy Rebuilding Task Force (Task Force). The Task Force was charged with identifying opportunities for achieving rebuilding success while supporting economic vitality, improving public health and safety, protecting and enhancing natural and manmade infrastructure, bolstering resilience, and ensuring appropriate accountability. The Department of the Interior (DOI) Strategic Sciences Group (SSG) was established in 2012 to provide interdisciplinary science-based scenarios for environmental crises affecting Departmental resources. In January 2013, the Secretary of the Interior directed the SSG to support the Department’s participation in the Task Force. The SSG assembled a team of experts from government, academia, and non-governmental organizations – Operational Group Sandy (OGS) – to develop scenarios for the impacts of Hurricane Sandy and future major storms on coastal communities and urban systems in the New York/New Jersey region. This report documents results from the March 2013 deployment of the OGS. It includes background information on Hurricane Sandy and the federal response; the OGS methodology; scenarios for Hurricane Sandy’s impact on coastal communities and urban ecosystems; potential interventions to improve regional resilience to future major storms; a discussion of scenario results; and lessons learned about the OGS process.
Brodal, Gerth StÃ¸lting
dobbeltÂsekskanterne har vÃ¦gt 2. Eksempelvis har H(1)Âgrafen vÃ¦gtet pÅ¡a denne mÅ¡ade fÃ¸lgende udseende 1 3 letteste udspÃ¦ndende trÃ¦ for grafen. # SpÃ¸rgsmÅ¡al c: Angiv vÃ¦gten af et letteste udspÃ¦ndende trÃ¦ for en vandrette kanter i enkeltÂsekskanterne har vÃ¦gt N (N erstatter 3), og hvor alle andre kanter i grafen har
Brodal, Gerth StÃ¸lting
vÃ¦gt 2. Eksempelvis har H(1)-grafen vÃ¦gtet pÂ°a denne mÂ°ade fÃ¸lgende udseende 1 3 1 3 2 2 2 2 2 2 2 2 2 for grafen. 2 SpÃ¸rgsmÂ°al c: Angiv vÃ¦gten af et letteste udspÃ¦ndende trÃ¦ for en sÂ°adan vÃ¦gtet H-sekskanterne har vÃ¦gt N (N erstatter 3), og hvor alle andre kanter i grafen har vÃ¦gte der er strengt stÃ¸rre end 1
Harm, Deborah L.
Motion sickness research is reviewed with the emphasis placed on theories developed to explain its symptomatology. A general review of central nervous system, autonomic nervous system, and neuroendocrine system involvement in the syndrome. Particular attention is given to signs, symptoms, and physiological correlates, methodological issues, and directions for future research based on a dynamic interactive systems model.
SARDINIA was believed to be a virus-free citrus region until Boselli1 first noted a disorder showing symptoms commonly referred to as the psorosis virus complex. Following this, the main citrus areas of the Island have been surveyed with the view of recognizing and recording virus or virus-like manifestations.
Kasap, Elmas; Ayer, Ahmet; Bozo?lan, Hümeyra; Ozen, Cigdem; Eslek, Ilhan; Yüceyar, Hakan
Background: Psychological factors and psychiatric disorders play a role in a variety of gastrointestinal illnesses, including esophageal diseases. Aim: The aim of the present study was to evaluate the frequency of gastroesophageal reflux disease symptoms in patients with schizophrenia in Turkey. Patients and Methods: Ninety-eight patients with schizophrenia and one hundred control individuals were enrolled in the study, which was undertaken at the Manisa State Hospital for Mental Health and Neurological Disorders and Celal Bayar University Gastroenterology Department. Case and control subjects alike underwent 30–45 min oral interviews conducted by a designated study coordinator (E.K.). The coordinator gathered information about demographic characteristics, social habits, and a large variety of symptoms suggestive of reflux disease or other gastrointestinal conditions. Results: In terms of reflux symptoms, cough was the only significant association in schizophrenic patients than controls. Heartburn and regurgitation were more frequent in schizophrenic patients who smoked than in controls who were smokers. However, the prevalence of reflux symptoms in cigarette smokers versus nonsmoker patients with schizophrenia was similar. Heartburn and/or regurgitation occurred more frequently in patients with schizophrenic than controls with alcohol use. Conclusions: Psychiatric disorders might indirectly affect esophageal physiology through increased consumption of alcohol and nicotine. PMID:25657460
Amodu, Enema Job; Fasunla, Ayotunde James; Akano, Aliu Oyebamiji; Daud Olusesi, Abiodun
Introduction Symptomatology, nasal endoscopy and Computerised Tomographic (CT) scan have been used to diagnose chronic rhinosinusitis. The value of disease severity score in the assessment of chronic rhinosinusitis has not been well investigated. Hence, this study aims to correlate the pre-operative symptom severity score as well as overall disease severity scoreof patients with chronic rhinosinusitis with CT scan scores. Methods This is a prospective study of 60 patients diagnosed clinically with chronic rhinosinusitis. Each patientsubjectively assessed his/her presenting symptoms and severity of disease on a visual analogue scale. The patients had CT scan of the paranasal sinuses which were graded and scored using Lund-Mackay grading system. The correlation study between severity of symptoms/disease severity and CT scores was performed. The level of statistical significance was considered at p < 0.05 and confidence interval at 95%. Results All patients had more than one symptom with mean symptom severity scores highest for nasal discharge and nasal obstruction. There was a significant correlation between CT scores and nasal discharge (r = -0.132; p = 0.03)and nasal obstruction (r = 0.193; p = 0.049). No correlation with other symptoms. There wasno correlation between the overall disease severity scores and the Lund-Mackay CT scores (r = 0.195; p = 0.6). Conclusion This study showed that CT scan scores can help clinicians to predict severity of symptom for nasal obstruction and discharge but not for other symptoms of chronic rhinosinusitis. However, there was no association of CT score with the overall disease severity score. PMID:25368729
Hong, Soon-Beom; Lee, Jong-Ha; Chun, Duk Hee; Shin, Min-Sup; Yoo, Hee-Jeong; Kim, Boong-Nyun; Cho, Soo-Churl
Objective People with attention-deficit/hyperactivity disorder (ADHD) exhibit considerable impairment in social, academic, or occupational functioning. The present study aimed to examine the patterns of associations between ADHD symptoms, depression, and family functioning. Methods The sample consisted of 1,022 adults randomly selected from a district in Seoul, South Korea. Several self-assessment scales were utilized to rate ADHD symptoms (both past and current), current symptoms of depression, and level of family functioning. ADHD symptoms in the children of these participants were also assessed. Pearson's correlation and multiple linear regression analyses were performed; structural equation modeling (SEM) was conducted to determine the best fitting model. Results Adult ADHD symptoms were positively associated with depressive symptoms. Depressive symptoms, in turn, mediated the relationship between adult ADHD symptoms and cohesion among family members. In addition, depressive symptoms mediated the relationship between adult ADHD symptoms and their children's ADHD symptoms. Conclusion The relationship between adult ADHD symptoms and family dysfunction may be influenced by depressive symptoms. When treating ADHD in adults, clinicians should pay attention to the presence or absence of depression. PMID:24843366
Frickmann, H; Jungblut, S; Holzknecht, N; Hansmann, M-L; Hanke, P
For the first time we describe a sclerosing mesenteritis that appeared acutely after abdominal operations. The patient suffered from diffuse abdominal symptoms. There was a hard tumour in the left middle and lower abdomen. Histological analysis revealed fibrosis and bone tissue. Symptoms improved after application of prednisone and high-calorie infusions. PMID:17024501
Brendel, Rebecca W.; Stern, Theodore A.
Lessons Learned at the Interface of Medicine and Psychiatry The Psychiatric Consultation Service at Massachusetts General Hospital (MGH) sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. Such consultations require the integration of medical and psychiatric knowledge. During rounds, Dr. Stern and the chief resident discuss the diagnosis and management of conditions confronted. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry. PMID:16308581
Luo, Yingqin; Fu, Cong; Zhang, Da-Yong; Lin, Kui
Background Overlapping genes (OGs) in bacterial genomes are pairs of adjacent genes of which the coding sequences overlap partly or entirely. With the rapid accumulation of sequence data, many OGs in bacterial genomes have now been identified. Indeed, these might prove a consistent feature across all microbial genomes. Our previous work suggests that OGs can be considered as robust markers at the whole genome level for the construction of phylogenies. An online, interactive web server for inferring phylogenies is needed for biologists to analyze phylogenetic relationships among a set of bacterial genomes of interest. Description BPhyOG is an online interactive server for reconstructing the phylogenies of completely sequenced bacterial genomes on the basis of their shared overlapping genes. It provides two tree-reconstruction methods: Neighbor Joining (NJ) and Unweighted Pair-Group Method using Arithmetic averages (UPGMA). Users can apply the desired method to generate phylogenetic trees, which are based on an evolutionary distance matrix for the selected genomes. The distance between two genomes is defined by the normalized number of their shared OG pairs. BPhyOG also allows users to browse the OGs that were used to infer the phylogenetic relationships. It provides detailed annotation for each OG pair and the features of the component genes through hyperlinks. Users can also retrieve each of the homologous OG pairs that have been determined among 177 genomes. It is a useful tool for analyzing the tree of life and overlapping genes from a genomic standpoint. Conclusion BPhyOG is a useful interactive web server for genome-wide inference of any potential evolutionary relationship among the genomes selected by users. It currently includes 177 completely sequenced bacterial genomes containing 79,855 OG pairs, the annotation and homologous OG pairs of which are integrated comprehensively. The reliability of phylogenies complemented by annotations make BPhyOG a powerful web server for genomic and genetic studies. It is freely available at . PMID:17650344
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Rhode Island, University of
, Sensitivity to light Aching muscles/joints back, shoulder, limbs General Sick Feeling tired, loss of appetite, and may experience nausea & vomiting Later Symptoms (By day 4) Early symptoms are replaced by
Gatzinsky, Vladimir; Jönsson, Linus; Ekerljung, Linda; Friberg, Lars-Göran; Wennergren, Göran
Background Oesophageal atresia (OA) is a congenital malformation that can lead to persistent respiratory symptoms in adulthood. Aim To describe the prevalence of respiratory symptoms in adulthood in a population-based study of patients with repaired OA and to compare this with the prevalence in the general population. Methods Of 80 patients operated for OA in Gothenburg in 1968–1983, 79 were located. The patients received a questionnaire on respiratory symptoms. Controls were 4979 gender- and age-matched subjects who answered the same questions. Results The questionnaire was answered by 73 of 79 (92%) patients. Physician-diagnosed asthma was reported by 30% in the OA group vs 10% in the control group (OR 4.1; 95% CI 2.4–6.8), and recurrent wheeze in 29% vs 5.5% (OR 6.9; 4.1–11.6). Also wheeze during the last year, asthma medication, a long-standing cough, cough with sputum production and chronic bronchitis were significantly more common among the patients with OA. In contrast, there was no significant difference regarding risk factors for asthma. The prevalence of respiratory symptoms did not appear to decrease with age. Conclusion A high prevalence of respiratory symptoms remains among adult patients with repaired OA. Many of the patients had an asthma diagnosis. However, asthma heredity or allergic rhinitis was not overrepresented. PMID:21418293
Nagase, H; Nakamura, H; Nakamura, H; Nohara, S; Miura, K; Ohnishi, T
This study was conducted to evaluate the relationship between the prevalence of subjective symptoms in workers using vibrating tools and the duration of chain saw operation and to examine whether the symptoms were relevant to factors other than the usage of vibrating tools. The statistical model of multivariate analysis was adapted to analyze individual data on the subjective symptoms of 317 chain saw operators. The obtained results were as follows: 1. In analysis of covariance, age-adjusted operating year in workers with peripheral circulatory, peripheral neurological and musculoskeletal disturbances was significantly longer than that without such disturbances. For these disturbances, partial regression coefficients of operating year were significantly high in multiple regression analysis. These results show that these disturbances and age-adjusted operating year are mutually closely related. 2. Multiple regression analysis showed that the partial regression coefficients of both operating year and age were low for nine symptoms, i.e. dulling sense of touch, joint pain, headache, dizziness and/or tinnitus, profuse sweating, discomfort of stomach, palpitation and/or dyspnea, hearing disturbance and lumbago. These results suggest that such symptoms were not related to either age or chain saw operation. 3. The results of principal component analysis were visualized in three-dimensional space in order to evaluate the relationships among the symptoms. The analysis showed that peripheral circulatory and neurological disturbances appeared independently and that general symptoms such as easy fatigability, headache, forgetfulness, vertigo and/or tinnitus, easy irritability, sleep disorder, profuse sweating, discomfort of stomach, palpitation and/or dyspnea, shoulder stiffness, hearing disturbance and lumbago consisted of four independent groups. Each group has no relationship with duration of chain saw operation. This suggests other harmful factors of the groups play a role in the prevalence of the symptoms. PMID:1753444
MARILYN GARSHOWITZ; THOMAS R. MARTIN
The present study examined the associations among the frequency of negative social interactions, personality traits, and depressive symptoms in university students. Subjects completed measures of negative social interactions, sociotropy, autonomy, perfectionism, and depressive symptoms. It was found in the total sample that higher depression symptoms scores were correlated significantly with the frequency of negative social interactions, sociotropy, autonomy, and socially
Ferol E. Mennen
This exploratory study looks at a sample of abused Latino children and evaluates the relationship of PTSD symptoms to other symptoms, characteristics of the abuse, and demographics. The results indicate that Latino children have a wide range of distress, with some children being highly symptomatic and others with few symptoms. The scores on the PTSD Inventory were related to scores
Ileana Berman; Anthony Kalinowski; Stuart M Berman; JoAnn Lengua; Alan I Green
The goals of the study were to determine the prevalence of obsessive or compulsive (OC) symptoms among chronic schizophrenic patients, and to elucidate the level of function and course of illness in chronic schizophrenic patients with and without such symptoms. Therapists of 102 patients with DSM-III-R diagnoses of chronic schizophrenia reported on their patients' OC symptoms, level of function, and
Praktikant til Socialdemokraternes Analyse-og Informationsafdeling (AIA) og Mette Frederiksen Senest i oktober vil der blive udskrevet valg i den forbindelse sger vi en praktikant, som har lyst til at vre
Senest i oktober vil der blive udskrevet valg Â i den forbindelse sÃ¸ger vi en praktikant, som har lyst. Vi har brug for en praktikant, der har mod pÃ¥ lidt af hvert, er fleksibel og kan tage selvstÃ¦ndige initiativer og er parat til at pÃ¥fÃ¸re sig et stort ansvar. Vi forventer at du: Har flair for kommunikation og
Qin, Xiang; Singh, Kavindra V.; Xu, Yi; Weinstock, George M.; Murray, Barbara E.
A mutant (TX5127) of Enterococcus faecalis OG1RF was generated by disruption mutagenesis of a previously described autolysin gene. TX5127 formed longer chains (2 to 10 cells per chain) than wild-type OG1RF (mainly single cells) during growth in broth even though it had a growth rate similar to that of the parental strain as measured by turbidity and cell count. Autolysin activity, as defined by the ability to lyse heat-killed Micrococcus lysodeikticus cells, was absent in TX5127, while this activity was easily detectable in OG1RF. However, disruption of this autolysin gene did not block the ability of TX5127 to hydrolyze E. faecalis cell walls compared to that of OG1RF. The autolysis rate of cells of TX5127 in 10 mM sodium phosphate buffer (pH 6.8) was slower than that of wild-type OG1RF. TX5127 also showed a decreased rate of lysis in the presence of penicillin, as measured by changes in the turbidity of the culture during 24 h of incubation at 37°C and a slightly decreased effect of penicillin as measured by time-kill curves. The virulence of TX5127 was similar to that of OG1RF in the mouse peritonitis model, indicating that the autolysin of E. faecalis is not important for infection in this model. PMID:9797220
Papanastasiou, D; Magiakou, M A; Giannopoulou, E; Kaklamanis, L
The physical examination of a 9 1/2 months old infant with repeated attacks of flushing, hypotonia and tachycardia, beginning at the age of 3 months revealed two indurated, brown coloured skin areas, each with a diameter of 2 cm, situated on the left side of the back and on the left buttock, respectively. The histological findings proved the clinically suspected diagnosis of a "solitary mastocytoma". No more generalised symptoms were observed after the surgical removal of the skin lesions during a follow up period of 24 months until today. PMID:3133559
Rhodes, Scott D.; Martinez, Omar; Song, Eun-Young; Daniel, Jason; Alonzo, Jorge; Eng, Eugenia; Duck, Stacy; Downs, Mario; Bloom, Fred R.; Allen, Alex Boeving; Miller, Cindy; Reboussin, Beth
Objective To estimate the prevalence and identify correlates of depressive symptoms among immigrant Latino sexual minorities. Methods Respondent-driven sampling (RDS) was used to estimate the prevalence of depressive symptoms, and univariate and multivariable analyses were conducted to identify correlates of depressive symptoms. Results Unweighted and RDS-weighted prevalence estimates of depressive symptoms were 69.2% and 74.8%, respectively. In the multivariable analysis, low social support, sexual compulsivity, and high self-esteem were significantly associated with increased depressive symptoms. Conclusions A need exists for culturally congruent mental health services for immigrant Latino sexual minorities in the southern United States. PMID:23985187
Takala, E P; Viikari-Juntura, E; Moneta, G B; Saarenmaa, K; Kaivanto, K
The objective of the investigation was to study the course of neck and shoulder symptoms and the predictors for these symptoms among women in light sedentary work. Postal surveys were conducted among 351 tellers (age 20-50 years) of a bank company in September, December, March, and May. The response rates were 74-90%. The outcome was the frequency of the symptoms during the previous three months. In the analysis, univariate explorations and random-effects logistic binomial regression for distinguishable responses were used. A change in the frequency of neck and shoulder symptoms was seen in 40.5% of the subjects during the follow-up period from autumn to spring. The frequency of the symptoms decreased from autumn and winter towards spring. The stability of the frequency of the symptoms was positively associated with age. Seasonal variation in symptoms should be considered when preventive programs against neck and shoulder disorders are planned and evaluated. PMID:1411369
Sansone, Randy A.; Sansone, Lori A.
Borderline personality is an Axis II disorder that has historically encompassed a number of different psychiatric symptoms. In empirical studies, these multiple psychiatric symptoms appear to manifest as numerous comorbid Axis I and II diagnoses. In echoing these findings in primary care settings, individuals with borderline personality exhibit prolific somatic symptoms. Rather than the type of symptom, are the number of symptoms suggestive of this disorder, such that proliferative psychiatric or medical symptoms are diagnostically relevant? We discuss these issues and conclude that the number of symptoms is an unacknowledged but important diagnostic feature in borderline personality disorder. This ongoing column is dedicated to the challenging clinical interface between psychiatry and primary care—two fields that are inexorably linked. PMID:19727271
Friis, L; Agréus, L; Edling, C
The objective of this cross-sectional study was to investigate the prevalence of abdominal symptoms and the abdominal medical history among sewage workers. 142 male sewage workers and 137 male referents in 11 Swedish municipalities were addressed with a questionnaire about abdominal symptoms, medical history, occupational history and life style factors. The sewage workers suffered less from nausea [adjusted odds ratio (adjOR) = 0.18, 95% confidence interval (Cl) 0.04-0.84] than the referents. There was no significant difference in the three months prevalence of diarrhoea (adjOR = 1.7, 95% Cl = 0.79-3.4), dyspepsia (adjOR = 0.85, 95% Cl = 0.49-1.5) or irritable bowel syndrome (adjOR = 1.4, 95% Cl = 0.53-3.5). The sewage workers were affected more often by peptic ulcers during their present jobs than the referents, although the increased risk was not significant (adjOR = 1.4, 95% Cl = 0.31-6.1). The odds ratios were adjusted for age, use of tobacco products and alcohol consumption. The conclusion of this study was that sewage workers are less affected by nausea than comparable referents. PMID:9800423
McDonald, Claire; Koshi, Sharon; Busner, Lorna; Kavi, Lesley; Newton, Julia L
Objective To examine a large UK cohort of patients with postural tachycardia syndrome (PoTS), to compare demographic characteristics, symptoms and treatment of PoTS at one centre compared to the largest patient group PoTS UK and to verify if their functional limitation is similar to patients with chronic fatigue syndrome (CFS). Design A cross-sectional study assessed the frequency of symptoms and their associated variables. Patients and setting Two PoTS cohorts were: (1) recruited via PoTS UK, (2) diagnosed at Newcastle Hospitals National Health Service (NHS) Foundation Trust 2009–2012. Patients with PoTS were then compared to a matched cohort with CFS. Main outcome measures Patients’ detailed demographics, time to diagnosis, education, disability, medications, comorbidity and precipitants. Symptom assessment tools captured, Fatigue Impact Scale, Epworth Sleepiness Scale, Orthostatic Grading Scale (OGS), Hospital Anxiety and Depression Scale, Health Assessment Questionnaire, Cognitive Failures Questionnaire. Results 136 patients with PoTS participated (84 members of PoTS UK (170 cohort; 50% return) and 52 (87 cohort; 60%) from Newcastle Clinics). The PoTS UK population was significantly younger than the clinic patients, with significantly fewer men (p=0.005). Over 60% had a university or postgraduate degree. Significantly more of the PoTS UK cohort were working, with hours worked being significantly higher (p=0.001). Time to diagnosis was significantly longer in the PoTS UK cohort (p=0.04). Symptom severity was comparable between cohorts. The PoTS total group was compared with a matched CFS cohort; despite comparable levels of fatigue and sleepiness, autonomic symptom burden (OGS) was statistically significantly higher. The most common treatment regime included ?-blockers. Overall, 21 treatment combinations were described. Up to 1/3 were taking no treatment. Conclusions Patients with PoTS are predominantly women, young, well educated and have significant and debilitating symptoms that impact significantly on quality of life. Despite this, there is no consistent treatment. PMID:24934205
Van Dyke, Sarah A; Millis, Scott R; Axelrod, Bradley N; Hanks, Robin A
The current study aimed to clarify the relationship among the constructs involved in neuropsychological assessment, including cognitive performance, symptom self-report, performance validity, and symptom validity. Participants consisted of 120 consecutively evaluated individuals from a veteran's hospital with mixed referral sources. Measures included the Wechsler Adult Intelligence Scale-Fourth Edition Full Scale IQ (WAIS-IV FSIQ), California Verbal Learning Test-Second Edition (CVLT-II), Trail Making Test Part B (TMT-B), Test of Memory Malingering (TOMM), Medical Symptom Validity Test (MSVT), WAIS-IV Reliable Digit Span (RDS), Post-traumatic Check List-Military Version (PCL-M), MMPI-2 F scale, MMPI-2 Symptom Validity Scale (FBS), MMPI-2 Response Bias Scale (RBS), and the Postconcussive Symptom Questionnaire (PCSQ). Six different models were tested using confirmatory factor analysis (CFA) to determine the factor model describing the relationships between cognitive performance, symptom self-report, performance validity, and symptom validity. The strongest and most parsimonious model was a three-factor model in which cognitive performance, performance validity, and self-reported symptoms (including both standard and symptom validity measures) were separate factors. The findings suggest failure in one validity domain does not necessarily invalidate the other domain. Thus, performance validity and symptom validity should be evaluated separately. PMID:24028487
Pradeep, Neeti; Sutin, Angelina R.
Depressive symptoms may co-occur within couples and follow similar trajectories, but relatively little is known about this process in old age. This study thus examined the association between some spousal characteristics (spouse's depressive symptoms, age difference between spouses) and the trajectory of depressive symptoms in older adults. Participants ?65 years old were drawn from the Health and Retirement Study (N = 12,010; Mean age = 70.60 and 69.16 for target husbands and wives, respectively). Depressive symptoms were measured with a short form of the Center for Epidemiological Studies Depression (CES-D) scale. Hierarchical Linear Modeling was used to model up to 9 assessments of depressive symptoms of target spouses (Mean number of CESD assessments per target spouse = 3, range 1–9). Depressive symptoms between spouses were correlated; convergence over time was modest. For both husbands and wives, having a younger spouse was associated with more depressive symptoms at age 65. These results suggest that there is concordance between spouses' depressive symptoms and that the age difference between spouses contribute to depressive symptoms as couples enter old age. The association between spouses' depressive symptoms is nearly as strong as the effect of each decade increase in age. PMID:25716455
Keeffe, Emmet B.; Lowe, Daniel K.; Goss, J. Richard; Wayne, Robert
A survey of 707 participants in the 13th Annual Trail's End Marathon in Seaside, Oregon, showed a high incidence of gastrointestinal disturbances, predominantly of the lower tract, associated with long-distance running. The urge to defecate, both during and immediately after running, occurred in over a third of runners. Bowel movements (35%) and diarrhea (19%) were relatively common after running, and runners occasionally interrupted hard runs or races for bowel movements (18%) or diarrhea (10%). Lower gastrointestinal disturbances were more frequent in women than in men and in younger than in older runners. Awareness of the frequency and nature of gastrointestinal symptoms documented by this survey will assist physicians in evaluating abdominal complaints in runners. PMID:6506684
Keeffe, E B; Lowe, D K; Goss, J R; Wayne, R
A survey of 707 participants in the 13th Annual Trail's End Marathon in Seaside, Oregon, showed a high incidence of gastrointestinal disturbances, predominantly of the lower tract, associated with long-distance running. The urge to defecate, both during and immediately after running, occurred in over a third of runners. Bowel movements (35%) and diarrhea (19%) were relatively common after running, and runners occasionally interrupted hard runs or races for bowel movements (18%) or diarrhea (10%). Lower gastrointestinal disturbances were more frequent in women than in men and in younger than in older runners. Awareness of the frequency and nature of gastrointestinal symptoms documented by this survey will assist physicians in evaluating abdominal complaints in runners. PMID:6506684
Pedley, T A
Because nonepileptic disorders may cause episodic and paroxysmal symptoms that resemble epilepsy, these conditions and syndromes must be considered in the differential diagnosis or when antiepileptic drugs are ineffective. Gastroesophageal reflux usually presents as recurrent vomiting in infants and young children. A small subgroup of infants develop apnea and cyanosis accompanied by posturing of the limbs, deviation of the eyes, or opisthotonos, which leads to the incorrect diagnosis of epilepsy. Breathholding spells and pallid infantile syncope, common in infants and young children, may also be mistaken for epileptic attacks. The parasomnias, including pavor nocturnus and somnambulism, are frequently mistaken for epilepsy, since these nocturnal episodes are paroxysmal in nature, may be associated with automatic behavioral mannerisms, and tend to be recurrent. Migraine is especially difficult to differentiate from epilepsy because its manifestations, particularly in children, are so diverse. Other disorders that may superficially mimic epilepsy include transient ischemic attacks, syncope, and transient global amnesia. PMID:6617595
Adaptiv hardware innen radar og radarapplikasjoner, Forsvarets forskningsinstitutt, Kjeller Forsvarets forskningsinstitutt (FFI) har mer enn 30 års erfaring med forskningsarbeider innen radar og radarapplikasjoner. Dette omhandler både passive systemer som brukes for å kartlegge radar scenen, kalt
mer enn 25 land. Konsernet leverer hÃ¸yteknologiske systemer til krevende kunder innen olje- og utviklingsmuligheter. VÃ¥r hverdag er dynamisk og hektisk med et godt arbeidsmiljÃ¸. Et solid selskap For mer informasjon
... Twitter. What Are the Signs and Symptoms of Heart Disease? The signs and symptoms of coronary heart ... will have signs and symptoms of the disease. Heart Disease Signs and Symptoms The illustration shows the ...
Targum, Steven D.
Research has shown that elderly patients are especially at risk for the development of psychotic symptoms. A combination of factors contributes to the increased risk for psychosis in this patient population. Various DSM-IV diagnostic categories including delirium, schizophrenia, delusional disorder, mood disorders, dementia, substance abuse, and medical-neurologic conditions can be associated with psychotic symptoms. In general, medications are prescribed for specific target symptoms, started at low doses, and titrated gradually. Although buspirone, trazodone, valproic acid, and carbamazepine have been used with some success, antipsychotic medications have been the primary treatment of psychosis in the elderly. Because the atypical antipsychotics offer effective management of psychotic symptoms combined with low liability of extrapyramidal symptoms, these agents may be the current treatment of choice for psychotic symptoms in the elderly when used cautiously. PMID:15014599
The aim of this study is to make symptomatic and urodynamic evaluation of the patients after unsuccessful primary transurethral\\u000a prostatectomy(TURP). Symptom score was not significantly different before and after TURP. Voiding symptoms were improved but\\u000a storage symptoms were impaired as well as a quality of life. Free flow was fairly improved after prostatectomy as well as\\u000a obstruction grade. Detrusor instability
Mooreville, Mira; Shomaker, Lauren B; Reina, Samantha A; Hannallah, Louise M; Adelyn Cohen, L; Courville, Amber B; Kozlosky, Merel; Brady, Sheila M; Condarco, Tania; Yanovski, Susan Z; Tanofsky-Kraff, Marian; Yanovski, Jack A
Depressive symptoms in youth may be a risk factor for obesity, with altered eating behaviors as one possible mechanism. We tested whether depressive symptoms were associated with observed eating patterns expected to promote excessive weight gain in two separate samples. In Study 1, 228 non-treatment-seeking youth, ages 12-17y (15.3±1.4y; 54.7% female), self-reported depressive symptoms using the Beck Depression Inventory. Energy intake was measured as consumption from a 10,934-kcal buffet meal served at 11:00am after an overnight fast. In Study 2, 204 non-treatment-seeking youth, ages 8-17y (13.0±2.8y; 49.5% female), self-reported depressive symptoms using the Children's Depression Inventory. Energy intake was measured as consumption from a 9835-kcal buffet meal served at 2:30pm after a standard breakfast. In Study 1, controlling for body composition and other relevant covariates, depressive symptoms were positively related to total energy intake in girls and boys. In Study 2, adjusting for the same covariates, depressive symptoms among girls only were positively associated with total energy intake. Youth high in depressive symptoms and dietary restraint consumed the most energy from sweets. In both studies, the effects of depressive symptoms on intake were small. Nevertheless, depressive symptoms were associated with significantly greater consumption of total energy and energy from sweet snack foods, which, over time, could be anticipated to promote excess weight gain. PMID:24424352
Hirsh, Adam T.; Gallegos, Juan C.; Gertz, Kevin J.; Engel, Joyce M.; Jensen, Mark P.
The current study sought to (1) determine the relative frequency and severity of eight symptoms in adults with cerebral palsy (CP), (2) examine the perceived course of these eight symptoms over time, and (3) determine the associations between the severity of these symptoms and psychosocial functioning. Eighty-three adults with CP completed a measure assessing the frequency, severity, and perceived course of eight symptoms (pain, weakness, fatigue, imbalance, numbness, memory loss, vision loss, and shortness of breath). Respondents also completed measures of community integration and psychological functioning. The results indicated that pain, fatigue, imbalance, and weakness were the most common and severe symptoms reported. All symptoms were reported to have either stayed the same or worsened, rather than resolved, over time. The symptoms were more closely related to social integration than to home integration, productive activity, or psychological functioning. Memory loss was a unique predictor of social integration in the multivariate context. This study highlighted several common and problematic symptoms experienced by adults with CP. Additional research is needed to identify the most effective treatments for those symptoms that affect community integration and psychological functioning as a way to improve the quality of life of individuals with CP. PMID:21174251
Whang, Kyumin; McDonald, Jonathan; Khan, Ambereen; Satsangi, Neera
Statins (e.g., simvastatin) have shown to induce expression of the bone morphogenic protein-2 gene in bone cells, but they are not used clinically because of a lack of a suitable delivery device. The overall objective is to develop optimized statin delivery devices for bone regeneration. The specific objective was to determine the effect of grafting statins to biodegradable poly[lactide-co-glycolide] (PLG) on release kinetics. Simvastatin was grafted to PLG (OG-PLG) and characterized using contact-angle measurements, attenuated total reflectance-Fourier transform infrared, and ultraviolet-visible spectroscopy to determine success of the synthesis. An ultraviolet-visible assay for measuring release of statins and degraded OG-PLG in media was also developed. In vitro release studies using films and scaffolds made with PLG, PLG blended with simvastatin (PLG + Sim), and OG-PLG (simvastatin grafted to PLG) blended into PLG at different concentrations showed that release rate of OG-PLG from films was significantly greater than that of PLG + Sim. However, release rate from scaffolds showed PLG + Sim to be significantly higher than that of OG-PLG. The diffusion-controlled release kinetics of simvastatin from PLG + Sim seems to be more heavily affected by device morphology, whereas the degradation-controlled release kinetics seem to be less affected. In short, release kinetics can be modulated by grafting statins to PLG. PMID:15981201
Anholt, Gideon E.; Cath, Danielle C.; van Oppen, Patricia; Eikelenboom, Merijn; Smit, Johannes H.; van Megen, Harold; van Balkom, Anton J. L. M.
In obsessive-compulsive disorder (OCD), the relationship between autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder (ADHD) symptom, and obsessive-compulsive (OC) symptom dimensions and severity has scarcely been studied. Therefore, 109 adult outpatients with primary OCD were compared to 87 healthy controls on OC, ADHD and…
Fa, Ng Sen; Hussin, Firuz Hussin
This paper presents the central ideas of a grounded theory research by the name of Triarchy Perspective on Metacognitive Learning in Free Online Groups, or "TriP on MetaL-FrOG" in short. The research setting was online learning community on the platform of Free Online Group web (FrOG) intended for post-graduate students. The research…
INFLUENZA 101 Symptoms of the flu Sudden onset of fever/chills, coughing, muscle aches, headache) a pharmacist may suggest other things for symptoms When you need to seek medical attention for Influenza dehydration) · Disorientation or confusion *Most people with influenza do not benefit from seeing their doctor
Pennsylvania, University of
for Sleep and Respiratory Neurobiology and Division of Sleep Medicine (Drs Gooneratne, Gehrman, NkwuoORIGINAL INVESTIGATION Consequences of Comorbid Insomnia Symptoms and Sleep-Related BreathingD Background: The prevalence of sleep-related breath- ing disorder (SRBD) and insomnia symptoms increases
Maddox, W. Todd
Research report Elevated depressive symptoms enhance reflexive but not reflective auditory category efficiency of the two learning systems. Previous studies have shown that individuals with elevated depressive are dissociable and competitive. We predicted that elevated depressive symptoms would lead to reflective
C. A. Tony Buffington
Background: Medically unexplained (or ‘functional’) symptoms (MUS) are physical symptoms that prompt the sufferer to seek healthcare but remain unexplained after an appropriate medical evaluation. Examples of MUS also occur in veterinary medicine. For example, domestic cats suffer a syndrome comparable to interstitial cystitis, a chronic pelvic pain syndrome of humans. Method: Review of current evidence suggests the hypothesis that
Kugler, Brittany B.; Bloom, Marlene; Kaercher, Lauren B.; Truax, Tatyana V.; Storch, Eric A.
Childhood exposure to trauma has been associated with increased rates of somatic symptoms (SS), which may contribute to diminished daily functioning. One hundred and sixty-one children residing at a residential treatment home who had experienced neglect and/or abuse were administered the Trauma Symptom Checklist for Children (TSCC), the…
Josée Rhéaume; Mark H. Freeston; Michel J. Dugas; Hélène Letarte; Robert Ladouceur
Although both perfectionism and responsibility have been associated with OCD at a theoretical level, responsibility has been the focus of a number of recent articles. This study was conducted in order to empirically test the relative importance of perfectionism and responsibility in Obsessive-Compulsive symptoms. Perfectionism and two measures of responsibility showed moderate correlations with Obsessive-Compulsive symptoms. A hierarchical regression analysis
Taylor, Julie Lounds; Warren, Zachary E.
The current study examined depressive symptoms, concerning the week following autism spectrum diagnosis and an average of 1.4 years later, in mothers (n = 75) of young children diagnosed with an autism spectrum disorder (ASD). Over three-quarters of mothers (78.7%) provided retrospective reports of clinically significant depressive symptoms…
M. Y. Berger; T. C. olde Hartman; A. M. Bohnen
Objective: To evaluate the effect of cholecystectomy in patients with gallstones on preoperative abdominal symptoms. Methods: A systematic search was made of the Medline database in combination with reference checking. Articles were excluded if patients aged Results: The pooled relief rate for “biliary pain” was high 92% (95% confidence interval 86 to 96%). Symptom relief rates were consistently higher in
Stone, Jon; Reuber, Markus; Carson, Alan
The mimics and chameleons of functional symptoms in neurology could be a whole textbook of neurology. Nevertheless, there are some recurring themes when things go wrong, notably diagnostic bias introduced by the presence or absence of psychiatric comorbidity or life events, neurological diseases that look 'weird' and lack of appreciation of the more unusual features of functional symptoms themselves. PMID:23468561
Gomez, Rapson; Vance, Alasdair
This study examined differential symptom functioning (DSF) in ADHD symptoms across Malay and Chinese children in Malaysia. Malay (N = 571) and Chinese (N = 254) parents completed the Disruptive Behavior Rating Scale, which lists the DSM-IV ADHD symptoms. DSF was examined using the multiple indicators multiple causes (MIMIC) structural equation…
Berant, Ety; Pizem, Noam
This study addresses the contribution of attachment orientations of ultra-orthodox volunteer rescuers involved in terror events to their posttraumatic symptoms, distress, and fear of death. The authors compared 53 ultra-orthodox rescuers operating in a terror-stricken area in Israel to 36 ultra-orthodox men unexposed to terror. Rescuers displayed lower distress than controls but were not significantly different in fear of death or posttraumatic symptoms. Attachment anxiety was found to be a risk factor by contributing uniquely to posttraumatic symptoms, distress, and fear of death, and as a debilitating factor among rescuers. PMID:25551333
Steigman, Pamela J; Pickett, Susan A; Diehl, Sita M; Fox, Anthony; Grey, Dennis D; Shipley, Patricia; Cook, Judith A
Depression has been shown to moderate the effects of physical illness self-management (ISM) programs. We attempted to replicate these findings for a mental ISM intervention. Outpatients with serious mental illness (N = 428) from eight Tennessee communities were randomly assigned to receive a peer-led self-management intervention called Building Recovery of Individual Dreams and Goals Through Education and Support or services as usual. Psychiatric symptoms were assessed with the Brief Symptom Inventory; the outcome of personal empowerment was measured by the Empowerment Scale. Intent-to-treat analysis using mixed-effects random regression found significant interaction effects between study condition and three moderating symptom profiles. Empowerment was greater for the intervention participants with high levels of depressive symptoms, anxiety symptoms, and general symptom distress than for the experimental participants with low symptom levels and the control subjects with high or low levels of symptoms. These results shed light on how mental ISM programs operate and ways these can be improved. PMID:24566504
White, Rebecca M. B.; Roosa, Mark W.
The family stress model posits that contextual stressors, such as neighborhood danger, negatively influence youth adjustment, including internalizing symptoms, via disruptions in parenting and family processes. The current study examined a culturally and contextually modified family stress model in a diverse sample of Mexican origin fathers and their children (N = 463) from the Southwestern U.S. Results supported the hypothesized negative influence of neighborhood danger on youth internalizing symptoms via disruptions in family cohesion. Paternal warmth did not play a role in linking contextual stress to outcomes. The role of harsh parenting was highly nuanced. Results suggest that both culture and context have the potential to moderate putative family stress model associations for specific parenting behaviors and further our understanding of the ways that culture and context may operate in models of family stress and youth outcomes. PMID:22383856
Marder, Stephen R.; Daniel, David G.; Alphs, Larry; Awad, A. George; Keefe, Richard S. E.
Individuals from academia, the pharmaceutical industry, and the US Food and Drug Administration used a workshop format to discuss important methodological issues in the design of trials of pharmacological agents for improving negative symptoms in schizophrenia. The issues addressed included the need for a coprimary functional measure for registration trials; the characteristics of individuals who should enter negative symptom trials; the optimal duration for a proof-of-concept or registration trial; the optimal design of a study of a broad-spectrum agent that treats both positive and negative symptoms or a co-medication that is added to an antipsychotic; the relative strengths and weaknesses of available instruments for measuring negative symptoms; the definition of clinically meaningful improvement for these trials; and whether drugs can be approved for a subdomain of negative symptoms. PMID:21270473
Abraham, Bincy P
Patients with inflammatory bowel disease can present with a wide variety of symptoms. Most are related to disease activity and should be managed with appropriate medical therapy for inflammatory bowel disease. However, some patients may develop symptoms due to the side effects of the medications, or due to immunosuppression. In these cases, the offending medications should be discontinued until resolution of the symptoms and a few may be able to restart therapy. Symptoms can also occur as an extraintestinal manifestation of the disease or due to concomitant autoimmune-mediated disorders. Regardless of the etiology, symptoms should be addressed promptly with immediate evaluation and appropriate therapy, as a delay may lead to permanent sequela. PMID:25905569
Myers, Catherine E.; VanMeenen, Kirsten M.; Servatius, Richard J.
Behavioral inhibition (BI), a temperamental bias to respond to novel stimuli with avoidance behaviors, is a risk factor for posttraumatic stress disorder (PTSD). It is unclear whether BI accounts for additional variance in PTSD symptom severity beyond that accounted for by general anxiety. Here, 109 veterans (mean age 50.4 years, 9.2% female) provided self-assessment of PTSD symptoms, state and trait anxiety, combat exposure, and current (adult) and retrospective (childhood) BI. Adult BI was correlated with anxiety and PTSD symptom severity, especially cluster C (avoidance) symptoms, but not with combat exposure. A regression model including adult BI, state and trait anxiety, and combat exposure was able to correctly classify over 80% of participants according to presence or absence of severe PTSD symptoms. Because avoidance behaviors are a core component of PTSD, self-assessments of BI may be an important tool in understanding PTSD and potentially assessing vulnerability to the disorder. PMID:22397911
Agathe Bourgogne; Danielle A Garsin; Xiang Qin; Kavindra V Singh; Jouko Sillanpaa; Shailaja Yerrapragada; Yan Ding; Shannon Dugan-Rocha; Christian Buhay; Hua Shen; Guan Chen; Gabrielle Williams; Donna Muzny; Arash Maadani; Kristina A Fox; Jason Gioia; Lei Chen; Yue Shang; Cesar A Arias; Sreedhar R Nallapareddy; Meng Zhao; Vittal P Prakash; Shahreen Chowdhury; Huaiyang Jiang; Richard A Gibbs; Barbara E Murray; Sarah K Highlander; George M Weinstock
Background \\u000a Enterococcus faecalis has emerged as a major hospital pathogen. To explore its diversity, we sequenced E. faecalis strain OG1RF, which is commonly used for molecular manipulation and virulence studies.\\u000a \\u000a \\u000a \\u000a \\u000a Results The 2,739,625 base pair chromosome of OG1RF was found to contain approximately 232 kilobases unique to this strain compared\\u000a to V583, the only publicly available sequenced strain. Almost no mobile
Hancox, Robert J; Shin, Hayden H; Gray, Andrew R; Poulton, Richie; Sears, Malcolm R
Smoking cannabis is associated with symptoms of bronchitis. Little is known about the persistence of symptoms after stopping cannabis use. We assessed associations between changes in cannabis use and respiratory symptoms in a population-based cohort of 1037 young adults.Participants were asked about cannabis and tobacco use at ages 18, 21, 26, 32 and 38?years. Symptoms of morning cough, sputum production, wheeze, dyspnoea on exertion and asthma diagnoses were ascertained at the same ages. Frequent cannabis use was defined as ?52 occasions over the previous year. Associations between frequent cannabis use and respiratory symptoms were analysed using generalised estimating equations with adjustments for tobacco smoking, asthma, sex and age.Frequent cannabis use was associated with morning cough (OR 1.97, p<0.001), sputum production (OR 2.31, p<0.001) and wheeze (OR 1.55, p<0.001). Reducing or quitting cannabis use was associated with reductions in the prevalence of cough, sputum and wheeze to levels similar to nonusers.Frequent cannabis use is associated with symptoms of bronchitis in young adults. Reducing cannabis use often leads to a resolution of these symptoms. PMID:25837035
Lagomasino, Isabel T; Harmon, Chris
Objective: To better characterize psychotic symptoms and their treatment in Hispanic populations. Design: Chart review. Setting: Chelsea MGH Health Center and Chelsea Counseling Center (both affiliates of the Massachusetts General Hospital). Participants: Forty-four Hispanic patients presenting with psychotic symptoms in the context of mood and anxiety disorders. Measurements: Chart review focussed on diagnosis, description, and cataloguing of psychotic symptoms and review of treatment efficacy. Results: All but two patients described some atypical psychotic symptoms (e.g., doorbells or telephones ringing, voices of children, and visual hallucinations of animals or relatives). Treatment varied; 34 percent received monotherapy (either neuroleptic, antidepressant, or anxiolytic); 61 percent received polypharmacy; of these, 48 percent received a combination of antidepressant and anxiolytic; 19 percent received antidepressant with neuroleptic; 14 percent received antidepressant with neuroleptic and anxiolytic. No regimen was significantly better than any other. Conclusions: Psychotic symptoms in Hispanic patients have been noted anecdotally to present differently from those described in other populations. Our review appears to support this observation. Clinicians who work with Hispanic patients should ask about these atypical psychotic symptoms. We provide speculation on the nature of these symptoms, review approaches to treatment, and make recommendations for further investigation. PMID:21120089
Al-Safi, Zain A; Santoro, Nanette
A majority of women will experience bothersome symptoms related to declining and/or fluctuating levels of estrogen during their menopausal transition. Vasomotor symptoms, vaginal dryness, poor sleep, and depressed mood have all been found to worsen during the menopausal transition. While vasomotor symptoms gradually improve after menopause, the time course can be many years. Vaginal dryness does not improve without treatment, while the long-term course of sleep and mood deterioration is not clearly defined at this time. A small minority of women have vasomotor symptoms that persist throughout the remainder of their lives. These common menopausal symptoms all improve with estrogen treatment. Over the last 10 years, we have witnessed a dramatic reduction in enthusiasm for menopausal hormone therapy, despite its high efficacy relative to other treatments. We have also seen the emergence of sound, evidence-based clinical trials of non-hormonal alternatives that can control the common menopausal symptoms. Understanding the natural history of menopausal symptoms, and the risks and benefits of both hormonal and non-hormonal alternatives, helps the clinician individualize management plans to improve quality of life. PMID:24613533
Background. Postpartum thyroiditis (PPT) is a common triphasic autoimmune disease in women with thyroid peroxidase (TPO) autoantibodies. This study evaluated women's thyroid disease symptoms, physical findings, stress levels, and thyroid stimulating hormone (TSH) levels across six postpartum months in three groups, TPO negative, TPO positive, and PPT positive women. Methods. Women were recruited in midpregnancy (n = 631) and TPO status was determined which then was used to form the three postpartum groups. The three groups were compared on TSH levels, thyroid symptoms, weight, blood pressure, heart rate, a thyroid exam, and stress scores. Results. Fifty-six percent of the TPO positive women developed PPT. Hypothyroid group (F (2, 742) = 5.8, P = .003) and hyperthyroid group (F (2, 747) = 6.6, P = .001) subscale scores differed by group. Several symptoms and stress scores were highest in the PPT group. Conclusions. The normal postpartum is associated with many symptoms that mimic thyroid disease symptoms, but severity is greater in women with either TPO or PPT positivity. While the most severe symptoms were generally seen in PPT positive women, even TPO positive women seem to have higher risk for these signs and symptoms. PMID:25405057
Thusgaard, Helle; Arnfred, Sidse Marie H
Turner syndrome is usually diagnosed by physical characteristics, i.e. low height and infertility. This case report presents a woman, who was referred to a chromosome analysis at the age of 35 years, due to a specific pattern of psychiatric symptoms. She felt childish, had strong emotional bonds to her family, yet lacked friendships and intimate relationships. She had moderate symptoms of obsessive-compulsive disorder with a sexual content. Confronted with this constellation of symptoms, psychiatrists and psychologists should be aware of Turner syndrome. PMID:23402244
Knechtle, Beat; Rüst, Christoph A; Rosemann, Thomas
We present three cases of patients with a thoracic disc herniation with misinterpretation of the initial symptoms. In a first case, pulmonary symptoms were prominent; in a second case, the patient complained of cardiac symptoms; and in a third case, the patient reported neurological symptoms. Ineffective investigation of thoracic symptoms should raise the suspicion of a thoracic disc herniation. PMID:25552446
Angela L. Rollins; Gary R. Bond; Paul H. Lysaker; John H. McGrew; Michelle P. Salyers
Objective: Although coping with positive symptoms of schizophrenia has been studied widely, few studies have examined coping with negative symptoms. This study compares the appraisal of stressfulness and coping patterns in response to positive and negative symptoms experienced by clients with schizophrenia attending a community mental health center.Methods: Clients were interviewed to assess symptom severity, appraisal of symptom stressfulness, and
DMFC Modul for intern transport og mobile anlæg Slutrapport: EPF05_33031_0011 Revision nr: 1, 7400 Herning, CVR: 26933048 Øvrige deltagere: IRD Fuel Cells A/S & Mini Crosser A/S #12;Slutrapport EFP.................................................................................................................3 4.3 - WP3 UDVIKLING AF DMFC STAK
Management Services Denmark A/S, 2001. #12;Indhold 1 Miljø- og energiafgifter i Danmark 5 1.1 Hvilke the indirect tax effect from environmental taxes imposed on domestic production of goods and services Risø-R-1297 (DA) ISBN: 87-550-2956-6 ISBN: 87-550-2957-4 (Internet) ISSN: 0106-2840 Print: Pitney Bowes
af blændens lille åbning. Kun en lille del af lyset slipper igennem og foto- graferes af detektoren A4. Fluorescens signal fra plantecellen i laserstrålens fokuspunkt slipper gennem blændens lille. Fluorescens signalet fra molekyler OVER fokusplanen stoppes af blændens lille åbning. Kun en lille del af
-unica Slutrapport PSO 339-52 #12;Slutrapport PSO 339-52 Albertslund Kommune Marts 2009 Indhold Indledning side 3 #12;Slutrapport PSO 339-52 Indledning I "Belysningsplan 2006" har Albertslund Kommune opstillet en herunder energiforbruget. Projektet PSO 339-52 omfatter udvikling og design af en ny energieffektiv LED
AARHUS UNIVERSITY AU HR 2011 Oplysninger til brug for skattekort og dansk skattepersonnummer (cpr-nr.) Lønmodtagere / Information for a tax card and a Danish tax registration number (Cpr number) - Salary earners worked or lived in Denmark? Ja/Yes Hvis ja skal du skrive dit skatteperson-nummer (cpr.nr.)/If yes fill
for iOS and Android smartphones and tablets. The app is developed in C# using Xamarin Studio ways for iOS and Android, and some focus will be put on these differences in implementation byggesagsdata til sagsbehandlere og borgere. Applikationen (app) er implementeret til iOS and Android
YI XU; BARBARA E. MURRAY; GEORGE M. WEINSTOCK
Our previous work identified a cosmid clone containing a 43-kb insert from Enterococcus faecalis OG1RF that produced a nonprotein antigen in Escherichia coli. In the present work, we studied this clone in detail. Periodate treatment of lysates of the clone confirmed that the antigen was carbohydrate in nature. Analysis of DNA sequences and transposon insertion mutants suggested that the insert
Forskere i Risøs Afdeling for Optik og Fluid Dynamik har på rekordtid udviklet en ny offsetpladerne. Gitterlaseren kan erstatte de dyre præcisions- lasere, man hidtil har været nødt til at bruge til. Brændetiden er afhæng- ig af laserens effekt; jo større effekt desto kor- tere brændetid. Derfor har laseren
Siden 1971 har forskere i Risøs Afdeling for Optik og Fluid Dynamik arbejdet på at udvik- le måleteknikker, der udnytter laserens spe- cielle egenskaber. På nuværende tidspunkt har afdelingen 37 aktive at computeren har fundet vej ind i flere menneskers hverdag, er problemer med "musearm" steget støt. At sidde
Design og udvikling af Android site specific browser Diplom IT Eksamensprojekt 2011 and development of the Wallboard mobile application, which is a mobile version of NetDesign's wallboard desktop will discuss the different technologies in the development of mobile applications. On the basis
California at Santa Cruz, University of
OG 1.2.18 1 Single hadrons in Milagro and the Spectrum of Cosmic Ray Protons Gaurang B. Yodh 1 Abstract Single unaccompanied hadrons can be used to probe the shape and intensity of the primary cosmic by single unaccompanied hadrons and the hadron energy measured from the response of the PMTs located below 7
California at Santa Cruz, University of
OG 4.4.06 1 Use of Instrumented Water Tanks for the Improvement of Air Shower Detector Sensitivity sensitivity to those of scintillation counters as applied to detecting extensive air showers (EAS. Considerable efforts have also been made to develop telescopes which detect VHE extensive air showers (EAS
... Learning Symptoms Most males with KS have normal intelligence quotients (IQs) 7 , 8 and successfully complete education at all levels. (IQ is a frequently used intelligence measure, but does not include emotional, creative, or ...
... Navigation Bar Home Current Issue Past Issues HIV / AIDS HIV / AIDS: Symptoms , Diagnosis, Prevention and Treatment Past Issues / Summer ... and have resulted in a dramatic decrease in AIDS deaths in the U.S. NIH Research to Results ...
Home care nursing (HCN) improves the management of symptoms in breast and colorectal cancer patients who take the oral chemotherapy drug capecitabine, according to a study published online November 16, 2009, in the Journal of Clinical Oncology.
... Unequal Vision, Blurred Vision, Double Changes in the Appearance of the Eyes Vision Loss, Sudden Other Eye Symptoms NOTE: This is the Consumer Version. CONSUMERS: Click here for the Professional Version ...
The Buteyko breathing technique is recommended in national guidance for control of asthma symptoms. This article explores the evidence base for the technique, outlines its main principles and includes two cases studies. PMID:23697004
... Difficulty with reading and/or writing Problems with math skills Difficulty remembering Problems paying attention Trouble following ... numbers. Other symptoms may include 7 : Difficulty with math-related word problems Trouble making change in cash ...
... Navigation Bar Home Current Issue Past Issues Feature Hepatitis Hepatitis: Symptoms, Diagnosis, Treatment & Prevention Past Issues / Spring 2009 ... No appetite Fever Headaches Diagnosis To check for hepatitis viruses, your doctor will test your blood. You ...
... worst cases, you can end up in a wheelchair. Some neuropathies can be fatal. Peripheral neuropathy symptoms ... drop in blood pressure and, consequently, dizziness when standing up; intestinal difficulties such as constipation or diarrhea; ...
Jonathan S. Starkman
Female bladder outlet obstruction following stress urinary incontinence surgery is well described but requires a high index\\u000a of suspicion given that patients often present clinically with both overactive bladder (OAB) and voiding symptoms. Furthermore,\\u000a only 25% of patients have frank urinary retention that requires indwelling or clean intermittent catheterization. Historically,\\u000a urethrolysis and sling lysis procedures ameliorate obstructive voiding symptoms with
Ashwin A. Patkar; Rajnish Mago; Prakash S. Masand
Psychotic symptoms frequently occur in patients with comorbid medical disorders and present a diagnostic and treatment challenge.\\u000a They may be a part of an independent psychiatric illness associated with the underlying medical condition or induced by substance\\u000a use or medications. The presence of psychotic symptoms can contribute to misdiagnosis or complicate the management of the\\u000a comorbid medical illness. Psychiatrists must
Cohen, Alex S.; Alpert, Murray; Nienow, Tasha M.; Dinzeo, Thomas J.; Docherty, Nancy M.
Accurate measurement of negative symptoms is crucial for understanding and treating schizophrenia. However, current measurement strategies are reliant on subjective symptom rating scales which often have psychometric and practical limitations. Computerized analysis of patients’ speech offers a sophisticated and objective means of evaluating negative symptoms. The present study examined the feasibility and validity of using widely-available acoustic and lexical-analytic software to measure flat affect, alogia and anhedonia (via positive emotion). These measures were examined in their relationships to clinically-rated negative symptoms and social functioning. Natural speech samples were collected and analyzed for 14 patients with clinically-rated flat affect, 46 patients without flat affect and 19 healthy controls. The computer-based inflection and speech rate measures significantly discriminated patients with flat affect from controls, and the computer-based measure of alogia and negative emotion significantly discriminated the flat and non-flat patients. Both the computer and clinical measures of positive emotion/anhedonia corresponded to functioning impairments. The computerized method of assessing negative symptoms offered a number of advantages over the symptom scale-based approach. PMID:17920078
Klest, Bridget; Freyd, Jennifer J.; Foynes, Melissa Ming
Eight-hundred thirty-three members of an ethnically diverse longitudinal cohort study in Hawaii were surveyed about their personal exposure to several types of traumatic events, socioeconomic resources, and mental health symptoms. Results replicated findings from prior research that while men and women are exposed to similar rates of trauma overall, women report more exposure to traumas high in betrayal (HB), while men report exposure to more traumas lower in betrayal (LB). Trauma exposure was predictive of mental health symptoms, with neglect, household dysfunction, and HB traumas predicting symptoms of depression, anxiety, PTSD, dissociation, and sleep disturbance, and LB traumas predicting PTSD and dissociation symptoms. Native Hawaiian ethnicity and poorer socioeconomic status were predictive of greater trauma exposure and symptoms. Results suggest that more inclusive definitions of trauma are important for gender equity, and that ethnic group variation in symptoms is better explained by factors such as differential trauma exposure and economic and social status differences, rather than minority status per se. PMID:24660048
Smedley, J; Inskip, H; Wield, G; Coggon, D
OBJECTIVE--To determine the prevalence of work related symptoms among radiographers compared with a control group of physiotherapists. METHOD--A postal questionnaire was used to collect information from radiographers and physiotherapists who registered in the United Kingdom during 1985-9. RESULTS--Satisfactory questionnaires were returned by 2354 (65%) of the radiographers and 3048 (69%) of the physiotherapists. There was a clear excess of work related symptoms among the radiographers. In particular, they were more likely to complain of symptoms that were worse at work, mouth soreness, sore, itchy, or runny eyes, persistent blocked nose, persistent itchy nose or sneezing, sore throat, headache, and of lower respiratory tract symptoms, which were also worse on workdays. These symptoms were associated particularly with the use of automatic processing machines. 235 radiographers gave a history of wheeze or chest tightness that had been worse at work or on days when at work. CONCLUSIONS--Work related symptoms suggesting irritation of the eyes and upper airways were more common in radiographers than controls, and may be related to exposure to x ray film processing chemicals. Men and women who reported work related wheeze or chest tightness will be followed up in more detail to assess the prevalence of occupational asthma in the cohort. PMID:8704868
... Twitter. What Are the Signs and Symptoms of Asthma? Common signs and symptoms of asthma include: Coughing . ... during the day or at night. What Causes Asthma Symptoms To Occur? Many things can trigger or ...
... What Are the Signs and Symptoms of Coronary Heart Disease? A common symptom of coronary heart disease ( ... narrow the coronary arteries. Signs and Symptoms of Heart Problems Related to Coronary Heart Disease Some people ...
... Twitter. What Are the Signs and Symptoms of Anemia? The most common symptom of anemia is fatigue ( ... mild symptoms or none at all. Complications of Anemia Some people who have anemia may have arrhythmias ( ...
... What Are the Signs and Symptoms of Fanconi Anemia? Major Signs and Symptoms Your doctor may suspect ... sisters also should be tested for the disorder. Anemia The most common symptom of all types of ...
... What Are the Signs and Symptoms of Aplastic Anemia? Lower than normal numbers of red blood cells, ... most of the signs and symptoms of aplastic anemia. Signs and Symptoms of Low Blood Cell Counts ...
... Twitter. What Are the Signs and Symptoms of Sarcoidosis? Many people who have sarcoidosis have no signs ... symptom is more common in women than men. Sarcoidosis Signs and Symptoms The illustration shows the major ...
... What Are the Signs and Symptoms of Carotid Artery Disease? Carotid artery disease may not cause signs or symptoms until it severely narrows or blocks a carotid artery. Signs and symptoms may include a bruit (broo- ...
... Navigation Bar Home Current Issue Past Issues Feature PTSD Symptoms, Diagnosis , Treatment Past Issues / Winter 2009 Table ... Symptoms As with mild traumatic brain injury (TBI), PTSD symptoms can be very subtle. "For example, some ...
Gale Harding; David Cella; Don Robinson; Parthiv J Mahadevia; Jason Clark; Dennis A Revicki
BACKGROUND: Renal cell carcinoma (RCC) has multiple symptoms stemming from disease and treatments. There are few validated scales for evaluating RCC symptoms. METHODS: A national cross-sectional study of adult RCC patients was conducted from October to December 2003 to define patient-reported RCC symptomology. Participants were asked open-ended questions regarding their signs and symptoms and completed an 86-item pilot questionnaire of
Rosenthal, David G; Learned, Nicole; Liu, Ying-Hua; Weitzman, Michael
Extensive research shows maternal depression to be associated with poorer child outcomes, and characteristics of these mothers have been described. Recent research describes associations of paternal depressive symptoms and child behavioral and emotional outcomes, but characteristics of these fathers have not been investigated. This study describes characteristics of fathers with depressive symptoms in the USA. Utilizing data from 7,247 fathers and mothers living in households with children aged 5-17 years who participated in the Medical Expenditure Panel Survey 2004-2006, the Patient Health Questionnaire-2 was used to assess parental depressive symptoms, the Short Form-12 was used to examine paternal and maternal physical health, the Columbia Impairment Scale was used to measure child behavioral or emotional problems, and the Children with Special Health Care Needs Screener was used to identify children with special health care needs. In multivariate analyses, poverty (AOR 1.52; 95% CI 1.05-2.22), maternal depressive symptoms (AOR 5.77; 95% CI 4.18-7.95), living with a child with special health care needs (AOR 1.42, 95% CI 1.04-1.94), poor paternal physical health (AOR 3.31; 95% CI 2.50-4.38) and paternal unemployment (AOR 6.49; 95% CI 4.12-10.22) were independently associated with increased rates of paternal depressive symptoms. These are the first data that demonstrate that poverty, paternal physical health problems, having a child with special health care needs, maternal depressive symptoms, and paternal unemployment are independently associated with paternal depressive symptoms, with paternal unemployment associated with the highest rates of such problems. PMID:22362259
Brodal, Gerth StÃ¸lting
Opgave 3 I denne opgave betragtes trÃ¦er, hvor knuderne har et variabelt antal sÃ¸nner, og i hvilke alle knuder har forskellige mÃ¦rkninger. En preorder hhv. postorder udskrift af et sÂ°adant trÃ¦ er man bÂ°ade har en preorder og en postorder udskrift af et trÃ¦, sÂ°a kan man entydigt bestemme trÃ¦et
Brodal, Gerth StÃ¸lting
Opgave 9 I denne opgave betragtes trÃ¦er, hvor knuderne har et variabelt antal sÃ¸nner, og i hvilke alle knuder har forskellige mÃ¦rkninger. En preorder hhv. postorder udskrift af et sÃ¥dant trÃ¦ er udskrift eller dets po- storder udskrift. c) Vis, at hvis man bÃ¥de har en preorder og en postorder udskrift
Reuber, M; Mitchell, A; Howlett, S; Crimlisk, H; Grunewald, R
Between 10 and 30% of patients seen by neurologists have symptoms for which there is no current pathophysiological explanation. The objective of this review is to answer questions many neurologists have about disorders characterised by unexplained symptoms (functional disorders) by conducting a multidisciplinary review based on published reports and clinical experience. Current concepts explain functional symptoms as resulting from auto-suggestion, innate coping styles, disorders of volition or attention. Predisposing, precipitating, and perpetuating aetiological factors can be identified and contribute to a therapeutic formulation. The sympathetic communication of the diagnosis by the neurologist is important and all patients should be screened for psychiatric or psychological symptoms because up to two thirds have symptomatic psychiatric comorbidity. Treatment programmes are likely to be most successful if there is close collaboration between neurologists, (liaison) psychiatrists, psychologists, and general practitioners. Long term, symptoms persist in over 50% of patients and many patients remain dependent on financial help from the government. Neurologists can acquire the skills needed to engage patients in psychological treatment but would benefit from closer working relationships with liaison psychiatry or psychology. PMID:15716517
Tentzeris, Vasileios; Lake, Blossom; Cherian, Thomas; Milligan, James; Sigurdsson, Audun
Oesophageal cancer presents as advanced disease; in the majority of patients the symptoms are present for many months prior to diagnosis. Dysphagia has been described as the key to an early diagnosis of oesophageal cancer. This study aims to assess the public perception of the importance of this symptom. Ninety-six patients completed a questionnaire. This evaluated patient understanding of symptoms of dysphagia compared to the finding of a breast lump, haemoptysis, chest pain and loss of weight concerning urgency, probable cause of symptoms and treatment required. Sixty-five patients (71%) would visit their GP within 24 h of finding a breast lump or suffering from haemoptysis (82%) or having chest pain (82%). Forty-seven patients (51%) who experienced dysphagia would seek medical advice after one week and further 18 (19%) after one month (P<0.0001). Only eight patients (10%) associated dysphagia with cancer compared to 53 patients (57%) with the finding of a breast lump (P<0.031). This study concludes that there is poor understanding of the main symptoms of oesophageal cancer. New health campaigns are needed if the cancer is to be detected at an earlier and potentially curable stage. PMID:20926460
Bacon, Tamar E.; Chamot, Eric; Salter, Amber R.; Cutter, Gary R.; Kalina, Jennifer T.; Herbert, Joseph
The North American Research Committee on Multiple Sclerosis (NARCOMS) Registry is a database that contains information from over 35,000 patient volunteers on symptom severity in 11 domains commonly affected in multiple sclerosis (MS): mobility, hand function, vision, fatigue, cognition, bowel/bladder function, sensory, spasticity, pain, depression, and tremor/coordination. The Registry affords a unique opportunity to study the frequency and severity of domain-specific impairment in a contemporary, mostly treated MS cohort over the course of the disease. The objective of this work was to calculate symptom prevalence in each of the 11 domains for years 0 to 30 from symptom onset. The resulting “symptom prevalence tables” demonstrate that a majority of participants perceive at least some degree of impairment in most domains as early as the first year of disease. The severity of impairment increases with disease duration across all domains, but the patterns of disability accumulation differ. The symptom prevalence tables illustrate the magnitude of perceived impact of the disease and highlight the extent of unmet need in symptomatic management. The tables are easy to use and allow MS patients and their clinicians to compare an individual's own impairment in any of the 11 domains to that of NARCOMS participants with the same disease duration. PMID:24453777
Rose, Amanda J.; Carlson, Wendy; Luebbe, Aaron M.; Schwartz-Mette, Rebecca A.; Smith, Rhiannon R.; Swenson, Lance P.
Youth's friendships serve important functions in development; however, internalizing symptoms may undermine these relationships. Two studies are presented that examine the association of depressive and anxiety symptoms with friendship adjustment. Study 1 tested concurrent effects and Study 2 tested prospective effects over 6 months. Like past…
Bijlenga, Denise; van der Heijden, Kristiaan B.; Breuk, Minda; van Someren, Eus J. W.; Lie, Maria E. H.; Boonstra, A. Marije; Swaab, Hanna J. T.; Kooij, J. J. Sandra
Objective: The authors explored associations between ADHD symptoms, seasonal depressive symptoms, lifestyle, and health. Method: Adult ADHD patients ("n" = 202) and controls ("n" = 189) completed the ASESA questionnaire involving lifestyle, eating pattern, and physical and psychological health, and validated measures on ADHD…
Garner, Annie A.; Mrug, Sylvie; Hodgens, Bart; Patterson, Cryshelle
Objective: Symptoms of sluggish cognitive tempo (SCT) are correlated with inattention and internalizing difficulties. The purpose of the present study was to determine whether symptoms of SCT reflect comorbid internalizing disorder with ADHD or a separate syndrome. Method: Using a clinical sample of youth evaluated for behavioral and learning…
Irvin, William; Muss, Hyman B.
Approximately 40,000 women die as a result of breast cancer each year and many more live with advanced disease. When breast cancer recurs, the goals of treatment often shift from one of cure to controlling the disease for as long as possible while palliating symptoms interfering with the patient's functional status and quality of life. This requires ongoing discussions with the patient and family about the goals of care. Many symptoms depend on the site of metastasis, with bone being the most frequent, and commonly occur with fatigue, depression, insomnia, and pain. The purpose of this paper is to identify and provide an overview of the management of the most common symptoms in patients with breast cancer metastases. PMID:21880861
Stephenson, D T; Price, J R
Medically unexplained physical symptoms (MUPS) are physical symptoms for which no relevant organic pathology can be found. Patients with MUPS commonly present to the emergency department (ED) but are rarely considered in emergency medicine teaching or literature. Management of these patients is frequently more challenging than where there is an obvious organic pathology. This review provides the emergency physician with background knowledge regarding the classification and aetiology of MUPS. It then provides strategies for more effective management, such as exploring the contribution of psychosocial factors with patients, explaining negative test results, and providing reassurance and avoiding creating iatrogenic anxiety. Early recognition of the fact that symptoms may not result from organic disease and an appreciation of the role of psychosocial factors may improve outcomes by reducing unnecessary investigation and admission, and avoiding reinforcement that encourages further similar presentations and unhelpful coping mechanisms. PMID:16858088
Lopez-Campos, Jose Luis; Calero, Carmen; Quintana-Gallego, Esther
Chronic obstructive pulmonary disease (COPD) has traditionally been considered an inexorably progressive disease, associated with a constant increase of symptoms that occur as the forced expiratory volume in 1 second (FEV1) worsens, only intermittently interrupted by exacerbations. However, this paradigm has been challenged in recent decades by the available evidence. Recent studies have pointed out that COPD-related symptoms are not consistently perceived by patients in the same way, showing not only seasonal variation, but also changes in symptom perception during a week or even within a single day. According to the available data, patients experience the biggest increase in respiratory symptoms during the first hours of the early morning, followed by the nighttime. This variation over time is of considerable importance, since it impacts on daily life activities and health-related quality of life, as measured by a recently developed ad hoc questionnaire. Additionally, recent clinical trials have suggested that the use of rapid-onset long-acting bronchodilators may have an impact on morning symptoms, despite their current use as maintenance treatment for a determined period. Although this hypothesis is to be validated in future long-term clinical trials comparing fast-onset versus slow-onset inhaled drugs in COPD, it may bring forward a new concept of long-term bronchodilator therapy. At the present time, the two available long-acting, fast-onset bronchodilators used in the treatment of COPD are formoterol and the recently marketed indacaterol. Newer drugs have also been shown to have a rapid onset of action in preclinical studies. Health care professionals caring for COPD patients should consider this variation in the perception of symptoms during their clinical interview as a potential new target in the long-term treatment plan. PMID:23687444
Suarez, G. A.; Opfer-Gehrking, T. L.; Offord, K. P.; Atkinson, E. J.; O'Brien, P. C.; Low, P. A.
OBJECTIVE: To develop a new specific instrument called the Autonomic Symptom Profile to measure autonomic symptoms and test its validity. BACKGROUND: Measuring symptoms is important in the evaluation of quality of life outcomes. There is no validated, self-completed questionnaire on the symptoms of patients with autonomic disorders. METHODS: The questionnaire is 169 items concerning different aspects of autonomic symptoms. The Composite Autonomic Symptom Scale (COMPASS) with item-weighting was established; higher scores indicate more or worse symptoms. Autonomic function tests were performed to generate the Composite Autonomic Scoring Scale (CASS) and to quantify autonomic deficits. We compared the results of the COMPASS with the CASS derived from the Autonomic Reflex Screen to evaluate validity. RESULTS: The instrument was tested in 41 healthy controls (mean age 46.6 years), 33 patients with nonautonomic peripheral neuropathies (mean age 59.5 years), and 39 patients with autonomic failure (mean age 61.1 years). COMPASS scores correlated well with the CASS, demonstrating an acceptable level of content and criterion validity. The mean (+/-SD) overall COMPASS score was 9.8 (+/-9) in controls, 25.9 (+/-17.9) in the patients with nonautonomic peripheral neuropathies, and 52.3 (+/-24.2) in the autonomic failure group. Scores of symptoms of orthostatic intolerance and secretomotor dysfunction best predicted the CASS on multiple stepwise regression analysis. CONCLUSIONS: We describe a questionnaire that measures autonomic symptoms and present evidence for its validity. The instrument shows promise in assessing autonomic symptoms in clinical trials and epidemiologic studies.
Michael L. Sulkowski; Amy Mariaskin; Eric A. Storch
Objective: This study investigated the occurrence of obsessive-compulsive spectrum disorders (OCSDs) and associated symptomology in college students. Participants: Participants included 358 undergraduate students. Results: Results suggest that clinically significant levels of OCSD symptoms are relatively common. Additionally, OCSD symptoms co-occurred with each other and anxiety symptoms in general, yet not significantly with impulsivity symptoms. Conclusions: Given their prevalence in college
W Mittenberg; D V DiGiulio; S Perrin; A E Bass
An affective, somatic, and memory check-list of symptoms was administered to subjects who had no personal experience or knowledge of head injury. Subjects indicated their current experiences of symptoms, then imagined having sustained a mild head injury in a motor vehicle accident, and endorsed symptoms they expected to experience six months after the injury. The checklist of symptoms was also
Bellis van den Berg; Linda Grievink; Rebecca K. Stellato; C. Joris Yzermans; Erik Lebret
BACKGROUND: Traumatic events are described as precipitating factors for medically unexplained symptoms. The aim of this study was to examine the prevalence and course of symptoms reported by disaster survivors and to assess whether the symptoms have features similar to those of medically unexplained symptoms. METHODS: A 3-wave longitudinal study was performed after an explosion of a fireworks depot. As
Julie Newman Kingery; Golda S. Ginsburg; Candice A. Alfano
Somatic symptoms are an associated feature of anxiety disorders that have received little research attention among non-White samples. In addition, the majority of previous studies have examined the influence of somatic symptoms in a cross-sectional rather than a prospective manner. This study examines the prevalence of 12 somatic symptoms, the association of somatic and anxiety symptoms (both concurrently and prospectively)
Norman Tran; John Elias; Ted Rosenberg; Douglas Wylie; Daria Gaborieau; Annalee Yassi
The release of waste anesthetic gases (WAG) in hospital operating rooms (ORs) was evaluated to determine if staff exposure to nitrous oxide exceeded the American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV®) and investigate possible correlations between symptoms and nitrous oxide exposure. The monitoring strategy consisted of nitrous oxide measurements by personal monitoring of the anesthetists and
FrÃ©dÃ©ric OgÃ© PRODIG UMR 8586 CNRS - 2, rue Valette - 75005 Paris ElÃ©ments pour servir Ã l pour servir Ã l'histoire et Ã la gÃ©ographie industrielles de la RÃ©gion Nord- Pas-de-Calais du dÃ©but du ............................................................................................................... 4 ELEMENTS POUR SERVIR A L'HISTOIRE ET LA GEOGRAPHIE INDUSTRIELLES DE LA REGION NORD
Luisa Brito; Graça Vieira; Mário A. Santos; Helena Paveia
Analysis of the nucleotide sequence ofLeuconostoc oenosplasmid pOg32 (2544 bp) revealed three open reading frames (ORFs) in one of the DNA strands preceded by putative promoters and ribosome binding sites. ORF1 corresponded to a polypeptide similar to the replication proteins (Rep) of pT181 plasmid family. A nucleotide sequence like the double strand origin (DSO) of the same plasmid family was
Kjelstrup Institutt for kjemi NKS Landsmøte, Lillestrøm, 29.30 oktober, 2014 #12;2 Tilegnet alle mine dr standard tilstand! Fult dekket overflate 300 K: 12.5 molekyl/(nm)² #12;Reservoar: 168 Å x 216 Å x 336 Å L Standard kjemisk potensial, entropi og entalpi for lagene 298 K Lag 1+2 Lag 1 Lag 2 CO2 gass µ0 kJ/mol 47
Layne, Ann E.; Bernstein, Gail A.; March, John S.
The present study aimed to determine which anxiety symptoms in children are associated with teacher awareness and whether teacher awareness differs according to student age and gender. The Multidimensional Anxiety Scale for Children (MASC) was completed by 453 second through fifth grade students and teachers nominated the three most anxious…
Sabia, Joseph J.
A recent study by the Heritage Foundation (Rector, Johnson, & Noyes, 2003) found evidence of a positive relationship between early sexual intercourse and depressive symptoms. This finding has been used to bolster support for funding abstinence only sex education. However, promoting abstinence will only yield mental health benefits if there is a…
Squire, Larry R.
PUZZLING SYMPTOMS: EATING DISORDERS AND THE BRAIN A FAMILY GUIDE TO THE NEUROBIOLOGY OF EATING TO DO WITH THE BRAIN? Although people with eating disorders struggle to eat normally, this is only now believe that part of the problem has to do with how our brains process information about
Dawson, Geraldine; Meltzoff, Andrew N.; Osterling, Julie; Rinaldi, Julie
Examined performance on neuropsychological tests (tapping the medial temporal lobe and related limbic structures, and the dorsolateral prefrontal cortex, respectively) in relation to performance on tasks assessing autistic symptoms in young children with autism, and developmentally matched children with Down syndrome or typical development.…
Joseph J. Sabia
A recent study by the Heritage Foundation (Rector, Johnson, & Noyes, 2003) found evidence of a positive relationship between early sexual intercourse and depressive symptoms. This finding has been used to bolster support for funding abstinenceonly sex education. However, promoting abstinence will only yield mental health benefits if there is a causal link between sexual intercourse and depression. Using the
Ann E. Layne; Gail A. Bernstein; John S. March
The present study aimed to determine which anxiety symptoms in children are associated with teacher awareness and whether teacher awareness differs according to student age and gender. The Multidimensional Anxiety Scale for Children (MASC) was completed by 453 second through fifth grade students and teachers nominated the three most anxious students in their classrooms. A multivariate analysis of variance was conducted
... Wide, short hands with short fingers A single, deep, crease across the palm of the hand A deep groove between the first and second toes In ... Developmental Symptoms Cognitive impairment, problems with thinking and learning, is common in people with Down syndrome and ...
Bandettini, Peter A.
Periodontal (Gum) Disease Causes, Symptoms, and Treatments U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health #12;Periodontal (Gum) Disease If you have been told you have periodontal (gum) disease, you're not alone. Many adults in the U.S. currently have some form of the disease
S. N. Raza; A. M. Fletcher; C. A. Pickering; R. M. Niven; E. B. Faragher
OBJECTIVES: To investigate a large population of cotton textile weavers for reported respiratory symptoms relative to occupational factors, smoking, and exposure to dust. Cotton processing is known to produce a respiratory disease known as byssinosis particularly in the early processes of cotton spinning. Relatively little is known about the respiratory health of the cotton weavers who produce cloth from spun
Paris-Sud XI, Université de
reported strong associations between EDS and bipolar-II disorder as well as major depressive disorder (MDD depressive symptoms and hypersomnia are complex and often bidirectional. Of the many disorders associated depression. However, most mood disorder studies addressing hypersomnia have assessed daytime sleepiness using
Patricia Van Oppen; Rense J. Hoekstra; Paul M. G. Emmelkamp
In the present study, the structure of obsessive-compulsive symptoms was investigated by means of the Padua Inventory (PI). Simultaneous Components Analysis on data from obsessive-compulsives (n = 206), patients with other anxiety disorders (n = 222), and a non clinical sample (n = 430) revealed a five-factor solution. These factors are: (I) impulses; (II) washing; (III) checking; (IV) rumination; and
Susan H. Spence; Ronald Rapee; Casey McDonald; Michelle Ingram
This study examined whether anxiety symptoms in preschoolers reflect subtypes of anxiety consistent with current diagnostic classification systems, or should be better regarded as representing a single dimension. Parents of a large community sample of preschoolers aged 2.5 to 6.5 years rated the frequency with which their children experienced a wide range of anxiety problems. Exploratory factor analysis indicated four
Adil Khan; Edward Faught; Frank Gilliam; Ruben Kuzniecky
The incidence of psychosis during clinical trials of topiramate was 0.8%, not significantly different from the rate for placebo or reported rates of psychosis in patients with refractory epilepsy. We observed psychotic symptoms in five patients soon after initiation of topiramate therapy. We performed a retrospective chart review of the first 80 patients who began on topiramate after approval for
Karl H. Wiedl; Barbara Schöttner
This article describes a method developed to assess coping with schizophrenia by inpatients and outpatients. The approach is based on a transactional theory of coping. Symptoms related to the disease, subjective appraisals given by the 40 patients, and coping behavior are assessed using a list of disease-related strains, rating scales, and a semistructured interview. Results of this study indicate that
Rice, Kenneth G; Sauer, Eric M; Richardson, Clarissa M E; Roberts, Kristin E; Garrison, Angela M
The primary goal of this study was to examine how perfectionism affects psychological symptoms during the course of treatment. We examined session-by-session symptom changes in a sample of 105 adult clients who presented for counseling at a psychology training clinic housed at a large Midwestern university in the United States. Using a recently developed measure of perfectionism (Short Almost Perfect Scale [SAPS]) that possesses good psychometric features, we were able to investigate effects of both maladaptive (high self-criticism) and adaptive (high standards with low self-criticism) perfectionistic characteristics on indicators of personal and interpersonal psychological distress across time. Multilevel modeling analyses indicated that both symptomatic distress and interpersonal problems improved over the course of therapy. Maladaptive perfectionism was associated with higher levels of interpersonal problems and distress at the outset of therapy, and related differentially to change patterns in symptom distress and interpersonal problems over the course of treatment. Maladaptive perfectionism, however, was not related to level of symptoms at the end of therapy. Adaptive perfectionistic characteristics were associated with fewer interpersonal problems at the beginning and end of therapy. Results suggest the value of assessing perfectionistic characteristics at the onset of treatment, even for clients not presenting with obvious concerns linked to such individual differences. (PsycINFO Database Record PMID:24866970
Siener, Shannon; Kerns, Kathryn A.
This study examined associations among several measures of emotion regulation, and their links to depressive symptoms, in a sample of children ages 10-12 years old (N = 87). Both temporal features of emotion regulation and regulation processes involved in the evaluation, monitoring, and modification of emotion were assessed through parent and…
Presnell, Katherine; Stice, Eric; Tristan, Jennifer
Prospective studies suggest that dieting increases risk for bulimic symptoms, but experimental trials indicate dieting reduces bulimic symptoms. However, these experiments may be unrepresentative of real-world weight loss dieting. In addition, the fact that most dieters do not develop eating disorders suggests moderating factors may be important. Accordingly, we randomly assigned 157 female intermittent dieters to either diet as they usually do for weight loss or eat as they normally do when not dieting for 4 weeks. Naturalistic dieting halted the weight gain shown by controls, but did not result in significant weight loss. Although there was no main effect of the dieting manipulation on bulimic symptoms, moderation analyses indicated that naturalistic dieting decreased bulimic symptoms among participants with initially low depressive symptoms. Results suggest that self-initiated weight loss dieting is not particularly effective, which appears to explain several discrepancies in the literature. Additionally, depressive symptoms may be an important determinant of bulimic symptoms that eclipses the effects of naturalistic dieting on this outcome. PMID:17662503
Denoux, Carine; Galletti, Roberta; Mammarella, Nicole; Gopalan, Suresh; Werck, Danièle; De Lorenzo, Giulia; Ferrari, Simone; Ausubel, Frederick M.; Dewdney, Julia
We carried out transcriptional profiling analysis in 10 day-old Arabidopsis thaliana seedlings treated with oligogalacturonides (OGs), oligosaccharides derived from the plant cell wall, or the bacterial flagellin peptide Flg22, general elicitors of the basal defense response in plants. Although detected by different receptors, both OGs and Flg22 trigger a fast and transient response that is both similar and comprehensive, and characterized by activation of early stages of multiple defense signaling pathways, particularly JA-associated processes. However, the response to Flg22 is stronger in both the number of genes differentially expressed and the amplitude of change. The magnitude of induction of individual genes is in both cases dose dependent, but even at very high concentrations, OGs do not induce a response that is as comprehensive as that seen with Flg22. While high doses of either microbe-associated molecular pattern (MAMP) elicit a late response that includes activation of senescence processes, SA-dependent secretory pathway genes and PR1 expression are substantially induced only by Flg22. These results suggest a lower threshold for activation of early responses than for sustained or SA-mediated late defenses. Expression patterns of aminocyclopropane-carboxylate synthase genes also implicate ethylene biosynthesis in regulation of the late innate immune response. PMID:19825551
Background Posttraumatic stress disorder (PTSD) following childbirth has gained growing attention in the recent years. Although a number of predictors for PTSD following childbirth have been identified (e.g., history of sexual trauma, emergency caesarean section, low social support), only very few studies have tested predictors derived from current theoretical models of the disorder. This study first aimed to replicate the association of PTSD symptoms after childbirth with predictors identified in earlier research. Second, cognitive predictors derived from Ehlers and Clark’s (2000) model of PTSD were examined. Methods N = 224 women who had recently given birth completed an online survey. In addition to computing single correlations between PTSD symptom severities and variables of interest, in a hierarchical multiple regression analyses posttraumatic stress symptoms were predicted by (1) prenatal variables, (2) birth-related variables, (3) postnatal social support, and (4) cognitive variables. Results Wellbeing during pregnancy and age were the only prenatal variables contributing significantly to the explanation of PTSD symptoms in the first step of the regression analysis. In the second step, the birth-related variables peritraumatic emotions and wellbeing during childbed significantly increased the explanation of variance. Despite showing significant bivariate correlations, social support entered in the third step did not predict PTSD symptom severities over and above the variables included in the first two steps. However, with the exception of peritraumatic dissociation all cognitive variables emerged as powerful predictors and increased the amount of variance explained from 43% to a total amount of 68%. Conclusions The findings suggest that the prediction of PTSD following childbirth can be improved by focusing on variables derived from a current theoretical model of the disorder. PMID:25026966
Paice, Judith A
The control, and ideally prevention, of symptoms such as pain, depression, and fatigue is dependent on a comprehensive clinical assessment. Furthermore, to advance the science of this field, symptom research requires the use of multidimensional instruments with proven validity and reliability in a cancer population across the lifespan. Studies demonstrate a significant correlation among pain, depression, fatigue, and other symptoms commonly seen throughout the course of cancer. Therefore, multidimensional scales incorporating the most common symptoms would ensure systematic assessment. Optimally, valid and reliable tools that measure symptom clusters would be feasible for use in both clinical and research settings. Currently available instruments that measure symptom clusters include the Edmonton Symptom Assessment Scale, the M.D. Anderson Symptom Inventory, the Memorial Symptom Assessment Scale, the Rotterdam Symptom Checklist, the Symptom Distress Scale, and others. Special populations include cancer patients with advanced disease, where symptom prevalence is expected to increase. Newer tools that attempt to address these populations are the Brief Hospice Inventory and the Hospice Quality of Life Index, appropriate for cancer patients with more advanced disease. Each of these tools has demonstrated utility in measuring symptom severity and quality of life. Few scales have been validated in the measurement of symptom clusters in children, in cognitively impaired adults, or in non-English speaking patients from various cultural backgrounds. The strengths and limitations presented in the clinical and research uses of each these instruments will be presented, as will be areas for future investigation. PMID:15263048
Delsedime, Nadia; Nicotra, Barbara; Giovannone, Maria Cristina; Marech, Lucrezia; Barosio, Marta; Marzola, Enrica; Abbate-Daga, Giovanni; Fassino, Secondo
With this paper we aimed to describe a case of a woman affected by Anorexia Nervosa Restricting subtype (AN-R) with delusional symptoms, visual hallucinations and severe body image distortion. We discussed the main AN diagnosis and whether delusional symptoms could be related to severity of AN describing also the use of olanzapine in such a severe clinical condition. The use of olanzapine was found to be effective to reduce both delusions and body distortions, and to improve compliance to treatments. We found a severe delusional symptomatology with mystic, omnipotence and persecution features. The psychotic structure seemed preceding the eating disorder and was also found to be worsened by emaciation. The use of antipsychotic helped reducing delusional symptoms and improving compliance to treatments. Finally, the dynamically oriented therapeutic relationship helped the patient to gain weight and to achieve a full recovery from psychotic symptoms. PMID:23757258
Joel T. Nigg; Oliver P. John; Lisa G. Blaskey; Cynthia L. Huang-Pollock; Erik G. Willicut; Stephen P. Hinshaw; Bruce Pennington
Attention-deficit\\/hyperactivity disorder (ADHD) in adulthood is conceptualized as originating in child- hood. Despite considerable theoretical interest, little is known about how ADHD symptoms relate to normal personality traits in adults. In 6 studies, the Big Five personality dimensions were related to ADHD symptoms that adults both recalled from childhood and reported concurrently (total N 1,620). Substantial effects emerged that were
Iseki, Chifumi; Furuta, Taiga; Suzuki, Masao; Koyama, Shingo; Suzuki, Keiji; Suzuki, Tomoko; Kaneko, Akiyo; Mitsuma, Tadamichi
A woman started to feel intractable pain on her lower legs when she was 76. At the age of 78, she was diagnosed as having Parkinson's disease (PD). The leg pain was suspected to be a symptom of PD after eliminating other causes. The patient also suffered from nonmotor symptoms, depression, anxiety, hot flashes, and paroxysmal sweating. Though the patient had received pharmacotherapy including levodopa for 5 years, she still suffered from the nonmotor symptoms and was referred to our department. We treated her with acupuncture based on the Chinese traditional medicine and electroacupuncture five times per week. After the 2-week treatment, the assessment for the symptoms was as follows; visual analogue scale (VAS) score of the leg pain was 16?mm (70?mm, before), Hamilton's rating scales for depression (HAM-D) score was 9 (18, before), timed 3?m Up and Go took 20 steps in 30?sec (24 steps in 38?sec, before), and the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part 1 score was 13 (21, before). Autonomic symptoms, hot flashes and paroxysmal sweating, were also alleviated. Acupuncture may be a good treatment modality for nonmotor symptoms in PD. PMID:25628905
Iseki, Chifumi; Furuta, Taiga; Suzuki, Masao; Koyama, Shingo; Suzuki, Keiji; Suzuki, Tomoko; Kaneko, Akiyo
A woman started to feel intractable pain on her lower legs when she was 76. At the age of 78, she was diagnosed as having Parkinson's disease (PD). The leg pain was suspected to be a symptom of PD after eliminating other causes. The patient also suffered from nonmotor symptoms, depression, anxiety, hot flashes, and paroxysmal sweating. Though the patient had received pharmacotherapy including levodopa for 5 years, she still suffered from the nonmotor symptoms and was referred to our department. We treated her with acupuncture based on the Chinese traditional medicine and electroacupuncture five times per week. After the 2-week treatment, the assessment for the symptoms was as follows; visual analogue scale (VAS) score of the leg pain was 16?mm (70?mm, before), Hamilton's rating scales for depression (HAM-D) score was 9 (18, before), timed 3?m Up and Go took 20 steps in 30?sec (24 steps in 38?sec, before), and the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part 1 score was 13 (21, before). Autonomic symptoms, hot flashes and paroxysmal sweating, were also alleviated. Acupuncture may be a good treatment modality for nonmotor symptoms in PD. PMID:25628905
Koljonen, Virve; Leikola, Junnu; Valanne, Leena; Hukki, Jyri
Purpose. We describe a case of 3-year-old girl with rhombencephalosynapsis, a rare cerebellar anomaly. Patient. A 3-year-old girl was admitted to our hospital due to congenital torticollis and asymmetry of face, skull and trunk. Craniosynostosis was suspected due to abnormal head shape. 3D-CT revealed closure of the sagittal suture without scaphocephalic skull. Due to atypical craniosynostosis with neurological symptoms, brain-MRI was performed revealing rhombencephalosynapsis. Results. Our patient presented with atypical craniosynostosis and balance problems, not typical for scaphocephaly. Operative treatment for craniosynotosis was not carried out because the cause of the problems was the cerebellum instead of the brain. Conclusions. Therefore, we conclude that patients with atypical craniosynostosis should be examined with brain-MRI to exclude the intracranial malformations, which 3D-CT does not reveal. Without brain-MRI, decision (not) to perform surgery could have been different. PMID:20029674
Kirkpatrick, M; Engleman, H; Minns, R A
The clinical features of 107 cases of children with hydrocephalus and measured raised intraventricular pressure were analysed retrospectively. Fifty one children had recently been diagnosed as having hydrocephalus, and the remainder had had shunts injected to direct the cerebrospinal fluid. The most common symptoms in the group were vomiting, behavioural changes, drowsiness, and headaches. The most common clinical signs were inappropriately increasing occipitofrontal head circumferences, tense anterior fontanelles, splayed sutures, and distension of the scalp veins. Half the infantile cases of hydrocephalus were without symptoms, and a quarter of the cases with cerebrospinal fluid shunts and measured raised intraventricular pressure were without signs. There were no fewer than 33 different clinical signs including several unusual ones, such as macular rash and sweating. We believe that the presentation of hydrocephalus with raised intraventricular pressure is sufficiently variable, unusual, or even absent to justify the direct measurement of intracranial pressure. PMID:2923462
South, Susan C; Turkheimer, Eric; Oltmanns, Thomas F
Pathological personality is strongly linked with interpersonal impairment, yet no study to date has examined the relationship between concurrent personality pathology and dysfunction in marriage--a relationship that most people find central to their lives. In a cross-sectional study of a community sample of married couples (N = 82), the authors used multilevel modeling to estimate the association of self- and spouse-reported symptoms of personality disorder (PD) with levels of marital satisfaction and verbal aggression and perpetration of physical violence. Inclusion of self- and spouse report of total PD symptoms resulted in improved model fit and greater variance explained, with much of the improvement coming after the addition of spouse report. The incremental validity of spouse report for several of the 10 PD scales was supported for marital satisfaction and verbal aggression, particularly for the Borderline and Dependent PD scales. PMID:18837594
South, Susan C.; Turkheimer, Eric; Oltmanns, Thomas F.
Pathological personality is strongly linked with interpersonal impairment, yet, no study to date has examined the relationship between concurrent personality pathology and dysfunction in marriage—a relationship most people find central to their lives. In a cross-sectional study of a community sample of married couples (N=82), multilevel modeling was used to estimate the association of self- and spouse reported PD symptoms with levels of marital satisfaction and verbal aggression and perpetration of physical violence. Including self- and spouse report of total PD symptoms resulted in improved model fit and greater variance explained, with much of the improvement coming after the addition of spouse-report. The incremental validity of spouse-report of several of the ten PD scales was supported for marital satisfaction and verbal aggression, particularly for borderline and dependent PD features. PMID:18837594
Lyketsos, Constantine G.; Carrillo, Maria C.; Ryan, J. Michael; Khachaturian, Ara S.; Trzepacz, Paula; Amatniek, Joan; Cedarbaum, Jesse; Brashear, Robert; Miller, David S.
Neuropsychiatric symptoms (NPS) are core features of Alzheimer’s disease and related dementias. Once thought to emerge primarily in people with late-stage disease, these symptoms are currently known to manifest commonly in very early disease and in prodromal phases, such as mild cognitive impairment. Despite decades of research, reliable treatments for dementia-associated NPS have not been found, and those that are in widespread use present notable risks for people using these medications. An Alzheimer’s Association Research Roundtable was convened in the spring of 2010 to review what is known about NPS in Alzheimer’s disease, to discuss classification and underlying neuropathogenesis and vulnerabilities, and to formulate recommendations for new approaches to tailored therapeutics. PMID:21889116
Kugler, Brittany B; Bloom, Marlene; Kaercher, Lauren B; Truax, Tatyana V; Storch, Eric A
Childhood exposure to trauma has been associated with increased rates of somatic symptoms (SS), which may contribute to diminished daily functioning. One hundred and sixty-one children residing at a residential treatment home who had experienced neglect and/or abuse were administered the Trauma Symptom Checklist for Children (TSCC), the Multidimensional Anxiety Scale for Children, and the Children's Depression Inventory (CDI). Primary caregivers completed the Child Behavior Checklist. Two composite measures of SS were formed to represent both child- and caregiver-rated SS. Over 95% of children endorsed at least one SS on the child-rated measure. Children who had experienced sexual abuse had higher rates of SS relative to children who had not. Child-rated SS were highly correlated with the CDI total score and the TSCC subscales of anxiety, depression, posttraumatic stress, dissociation, and anger. The TSCC anxiety subscale mediated the relationship between sexual abuse and child-rated SS. PMID:22395849
Stanley van den Noort
The signs and symptoms of multiple sclerosis (MS) range from those that command the immediate attention of patient and doctor\\u000a to those that escape the attention of patient and family over the course a lifetime. For nearly a century, we have discovered\\u000a some examples of MS found at autopsy that were never recognized by the family. In the modern era,
Randy O. Frost; Meredith S. Krause; Gail Steketee
The present study attempts to extend recent research on the relation between hoarding and obsessive-compulsive experiences. In both college student and community samples, hoarding was associated with higher scores on the Yale-Brown Obsessive-Compulsive Scale (YBOCS). The relationship was stronger among the community sample, in which there was a greater range of compulsive symptoms and hoarding behavior. Hoarding was also associated
M. Haney; Amie S. Ward; Sandra D. Comer; Richard W. Foltin; Marian W. Fischman
Symptoms of withdrawal after oral ?9-tetrahydrocannabinol (THC) administration have been reported, yet little is known about the development of dependence on\\u000a smoked marijuana in humans. In a 21-day residential study, marijuana smokers (n = 12) worked on five psychomotor tasks during the day (0915–1700 hours), and in the evening engaged in recreational activities\\u000a (1700–2330 hours); subjective-effects measures were completed 10
Joseph R. DiFranza; Nancy A. Rigotti; Ann D. McNeill; Judith K. Ockene; Judith A. Savageau; Dorothy M. St. Cyr; Mardia A. Coleman
OBJECTIVES: It has been assumed that nicotine dependence has a slow onset and occurs only after prolonged daily use of tobacco. A cohort of young adolescents was followed to determine when the first symptoms of nicotine dependence occur with respect to the duration and frequency of tobacco use.\\u000aDESIGN: A cohort of 681 seventh grade students (age 12-13 years) from
Antal, András; Kocsis, Béla
The authors present a case of enterobiasis of the appendix. Enterobius infection is an uncommon cause of acute appendicitis. Preoperative diagnosis of pinworm infestation is almost impossible unless there is a strong clinical suspicion. Parasites may produce symptoms which resemble acute appendicitis. Careful observation of the appendix stump may lead to intraoperative diagnosis of enterobiasis. A quick diagnosis and appropriate treatment may prevent future complications. PMID:18799410
Brian L. Thompson; Jennifer Waltz
Neff 's (2003a, 2003b) notion of self-compassion emphasizes kindness towards one's self, a feeling of connectedness with others, and mindful awareness of distressing experiences. Because exposure to trauma and subsequent posttraumatic stress symptoms (PSS) may be associated with self-criticism and avoidance of internal experiences, the authors examined the relationship between self-compassion and PSS. Out of a sample of 210 university
Kenneth G. Rice; Steven L. Pence
This study was designed to determine whether perfectionism, as assessed by the revised almost perfect scale (APS-R; R. B.\\u000a Slaney, M. Mobley, J. Trippi, J. S. Ashby, & D. G. Johnson, 1996), was a significant predictor of obsessive-compulsive (OC)\\u000a symptoms in a non-clinical sample of 308 university students. Perfectionistic discrepancy emerged as a general predictor of\\u000a obsessive thought difficulties and
Bondü, Rebecca; Scheithauer, Herbert
School shooters are often described as narcissistic, but empirical evidence is scant. To provide more reliable and detailed information, we conducted an exploratory study, analyzing police investigation files on seven school shootings in Germany, looking for symptoms of narcissistic personality disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) in witnesses' and offenders' reports and expert psychological evaluations. Three out of four offenders who had been treated for mental disorders prior to the offenses displayed detached symptoms of narcissism, but none was diagnosed with narcissistic personality disorder. Of the other three, two displayed narcissistic traits. In one case, the number of symptoms would have justified a diagnosis of narcissistic personality disorder. Offenders showed low and high self-esteem and a range of other mental disorders. Thus, narcissism is not a common characteristic of school shooters, but possibly more frequent than in the general population. This should be considered in developing adequate preventive and intervention measures. PMID:25063684
Bryant, Richard A; O'Donnell, Meaghan L; Creamer, Mark; McFarlane, Alexander C; Silove, Derrick
Reexperiencing symptoms are a key feature of posttraumatic stress disorder (PTSD). This study investigated the pattern of reexperiencing symptoms in non-PTSD posttraumatic disorders. This study recruited 1084 traumatically injured patients during hospital admission and conducted follow-up assessment 12 months later (N = 817, 75%). Twelve months after injury, 22% of patients reported a psychiatric disorder they had never experienced prior to the traumatic injury. One-third of patients with a non-PTSD disorder satisfied the PTSD reexperiencing criteria. Whereas patients with a non-PTSD disorder were more likely to experience intrusive memories, nightmares, psychological distress and physiological reactivity to reminders, only patients with PTSD were likely to experience flashback memories (OR: 11.41, 95% CI: 6.17-21.09). The only other symptom that was distinctive to PTSD was dissociative amnesia (OR: 4.50, 95% CI: 2.09-9.71). Whereas intrusive memories and reactions are common across posttraumatic disorders, flashbacks and dissociative amnesia are distinctive to PTSD. PMID:21159353
Barton, Debra L; Ganz, Patricia A
By 2022, the number of survivors is expected to grow to nearly 18 million. Therefore, addressing acute and chronic negative sequelae of a cancer diagnosis and its treatments becomes a health imperative. For women with a history of breast cancer, one of the common goals of treatment and prevention of recurrence is to reduce circulating concentrations of estradiol, especially in women with hormone receptor positive breast cancer. Hormone deprivation after a diagnosis of breast cancer impacts physiological targets other than in the breast tissue and can result in unwanted side effects, all of which can negatively impact quality of life and function and cause distress. Symptoms that are most strongly linked by evidence to hormone changes after cancer diagnosis and treatment include hot flashes, night sweats, sleep changes, fatigue, mood changes, and diminishing sexual function, including vaginal atrophy (decreased arousal, dryness and dyspareunia), infertility, decreased desire and negative self-image. Weight gain and resulting body image changes are often concomitants of the abrupt onset of treatment-induced menopause.The purpose of this chapter is to briefly review what is known about the advent of premature menopause in women treated for breast cancer, menopausal symptoms that are exacerbated by endocrine treatments for breast cancer, and the associated concerns of hot flashes and related menopausal symptoms, sexual health and fertility issues. We will discuss limitations in the current research and propose strategies that address current limitations in order to move the science forward. PMID:26059933
Yoo, Hee Jeong; Cho, Soo Churl; Ha, Jihyun; Yune, Sook Kyung; Kim, Seog Ju; Hwang, Jaeuk; Chung, Ain; Sung, Young Hoon; Lyoo, In Kyoon
The objective of this study was to evaluate the relationship between attention deficit-hyperactivity/impulsivity symptoms and Internet addiction. In total, 535 elementary school students (264 boys, 271 girls; mean age, 11.0 +/- 1.0 years) were recruited. The presence or severity of Internet addiction was assessed by the Young's Internet Addiction test. Parents and teachers of the children completed the DuPaul's attention deficit hyperactivity disorder (ADHD) rating scale (ARS; Korean version, K-ARS) and Child Behavior Checklists. Children with the highest and lowest quartiles in K-ARS scores were defined to be in ADHD and non-ADHD groups, respectively. Five children (0.9%) met criteria for a definite Internet addiction and 75 children (14.0%) met criteria for a probable Internet addiction. K-ARS scores had significant positive correlations with Young's Internet Addiction test scores. The Internet addiction group had higher total scores of K-ARS and ADHD-related subcategories in the Child Behavior Checklists than the non-addiction group. The ADHD group had higher Internet addiction scores compared with the non-ADHD group. Therefore, significant associations have been found between the level of ADHD symptoms and the severity of Internet addiction in children. In addition, current findings suggest that the presence of ADHD symptoms, both in inattention and hyperactivity-impulsivity domains, may be one of the important risk factors for Internet addiction. PMID:15482579
Hollingsworth, John M; Wilt, Timothy J
Benign prostatic hyperplasia (BPH) is a highly prevalent and costly condition that affects older men worldwide. Many affected men develop lower urinary tract symptoms, which can have a negative impact on their quality of life. In the past, transurethral resection of the prostate (TURP) was the mainstay of treatment. However, several efficacious drug treatments have been developed, which have transformed BPH from an acute surgical entity to a chronic medical condition. Specifically, multiple clinical trials have shown that ? adrenoceptor antagonists can significantly ameliorate lower urinary tract symptoms. Moreover, 5? reductase inhibitors, alone or combined with an ? adrenoceptor antagonist, can reverse the natural course of BPH, reducing the risk of urinary retention and the need for surgical intervention. Newer medical regimens including the use of antimuscarinic agents or phosphodiesterase type 5 inhibitors, have shown promise in men with predominantly storage symptoms and concomitant erectile dysfunction, respectively. For men who do not adequately respond to conservative measures or pharmacotherapy, minimally invasive surgical techniques (such as transurethral needle ablation, microwave thermotherapy, and prostatic urethral lift) may be of benefit, although they lack the durability of TURP. A variety of laser procedures have also been introduced, whose improved hemostatic properties abrogate many of the complications associated with traditional surgery. PMID:25125424
Donovan, Kristine A; Boyington, Alice R; Ismail-Khan, Roohi; Wyman, Jean F
A large body of research has documented the prevalence and severity of menopausal symptoms, especially vasomotor symptoms, in breast cancer survivors and their impact on quality of life. However, urinary symptoms as part of the constellation of menopausal symptoms have received relatively little attention. Thus, less is known about the prevalence and severity of urinary symptoms in breast cancer survivors. The authors of this report conducted a systematic review of studies published between 1990 and 2010 to describe the prevalence and severity of urinary symptoms in breast cancer survivors. In total, 16 eligible studies that involved >2500 women were identified. The studies varied with respect to purpose, design, and nature of the samples included; the majority used the same definition and assessment approach for urinary symptoms. Prevalence rates for symptoms ranged from 12% of women reporting burning or pain on micturition to 58% reporting difficulty with bladder control. Although, in many studies, the largest percentage of women rated symptoms as mild, 23% reported severe symptoms. Symptoms appeared to adversely affect women's quality of life. The authors concluded that there is a need for additional research assessing the natural history of urinary symptoms using consensus definitions and validated measures in diverse populations. Nevertheless, this review suggested that clinicians should screen for urinary symptoms in breast cancer survivors and should offer treatment recommendations or make referrals as appropriate. PMID:21751193
Salthouse, Timothy A
A total of 3,781 healthy adults between 18 and 97 years of age completed trait anxiety and depressive symptoms inventories and also performed a battery of cognitive tests. Consistent with recent research on cognitive abilities, the cognitive variables could be organized into a hierarchical structure, with 5 first-order abilities and a single g-factor representing the variance common to the first-order abilities at the top of the hierarchy. Analyses were conducted to determine where in this hierarchy effects associated with trait anxiety and depressive symptoms were operating. The results indicated that trait anxiety and depressive symptoms had significant relations at the highest level in the hierarchy of cognitive abilities, but few relations of either characteristic were evident on the cognitive abilities, or on measures of working memory, after controlling influences at the g-factor level. PMID:22023357
Drake, Christopher L; Vargas, Ivan; Roth, Thomas; Friedman, Naomi P
This study examined the associations between reported quantitative sleep measures and multiple daytime impairment domains. We collected data from a subsample of adults (n = 513) from the Colorado Longitudinal Twin Study and Community Twin Study. Results revealed that greater insomnia symptom frequency (days per week) significantly predicted greater global sleep-related functional impairment and depressive symptoms. Sleep onset latency was also positively associated with depressive symptoms. Receiver operating characteristic curve analyses indicated 3-4 nights per week and 36-40 min provided optimal sensitivity and specificity for impairment. Thus, insomnia frequency and sleep latency are critical in understanding the impact of insomnia on multiple impairment domains. Using functional impairment as criterion, these findings also support the use of specific quantitative cutoffs for sleep measures in diagnostic systems. PMID:24617964
Kim, Su Yeong; Chen, Qi; Li, Jing; Huang, Xuan; Moon, Ui Jeong
Using a sample of 388 father–adolescent and 399 mother–adolescent dyads in Chinese immigrant families, the current investigation tested Portes and Rumbaut's (1996) assertion that generational dissonance may indicate a family context that places children at increased risk for adverse outcomes. Study findings suggest that a high discrepancy in father–adolescent acculturation levels relates significantly to more adolescent depressive symptoms. The study further demonstrates that the quality of the parenting relationship between fathers and adolescents operates as a mediator between father–adolescent acculturation discrepancy and adolescent depressive symptoms. Specifically, a high level of discrepancy in American orientation between fathers and adolescents is associated with unsupportive parenting practices, which, in turn, are linked to more adolescent depressive symptoms. These relationships are significant even after controlling for the influence of family socioeconomic status and parents’ and adolescents’ sense of discrimination within the larger society. PMID:19586205
In most episodes of health complaints reported in office buildings in the last-twenty years, causal factors have not been identified. In order to assess risk factors for work-related symptoms in office workers, a reanalysis was performed of previous studies, and an epidemiologic study was conducted. The reanalysis of data, showed remarkable agreement among studies. Air-conditioned buildings were consistently associated with higher prevalence of headache, lethargy, and eye, nose, or throat problems. Humidification was not a necessary factor for this higher prevalence. Mechanical ventilation without air-conditioning was not associated with higher symptom prevalence. A study was conducted among 880 office workers, within 12 office buildings selected without regard to worker complaints, in northern California. A number of factors were found associated with prevalence of work-related symptoms, after adjustment in a logistic regression model for personal, psychosocial, job, workspace, and building factors. Two different ventilation types were associated with increases Ln symptom prevalence, relative to workers in naturally ventilated buildings: mechanical supply and exhaust ventilation, without air conditioning and with operable windows; and air-conditioning with sealed windows. No study buildings were humidified. In both these ventilation types, the highest odds ratios (ORs) found were for skin symptoms (ORs-5.0, 5.6) and for tight chest or difficulty breathing (ORs-3.6, 4.3). Use of carbonless copies or photocopiers, sharing a workspace, carpets, new carpets, new walls, and distance from a window were associated with symptom increases. Cloth partitions and new paint were associated with symptom decreases.
Dobkin, Roseanne DeFronzo; Menza, Matthew; Bienfait, Karina L.; Gara, Michael; Marin, Humberto; Mark, Margery H.; Dicke, Allison; Friedman, Jill
Objective Parkinson’s disease is frequently complicated by depression (dPD) and there is a paucity of controlled research that can inform the management of this disabling non-motor complaint. A randomized controlled trial of nortriptyline, paroxetine, and placebo for the treatment of dPD was recently completed. The purpose of this paper is to describe the baseline pattern of depressive symptom presentation in PD, the specific symptoms of dPD that improve with pharmacotherapy, and the residual symptoms which remain in patients who meet a priori criteria for response or remission after acute treatment (8-weeks). Setting The Departments of Psychiatry and Neurology at Robert Wood Johnson Medical School. Participants Fifty-two depressed patients (Major Depression or Dysthymia based on DSM-IV criteria) with Parkinson's disease (by research criteria). Design/Intervention A randomized controlled trial of nortriptyline, paroxetine, and placebo. Measurement The four subscales (core mood, anxiety, insomnia, somatic) and individual items from the Hamilton Rating Scale for Depression (HAM-D-17) were the focus of the current study. These measures were assessed at baseline and week 8. Results Baseline depressive symptoms were unrelated to motor functioning. Treatment response was associated with significant improvements in the core mood, anxiety, insomnia, and somatic symptoms seen in dPD. Residual symptoms, like sadness and loss of interest, persisted in treatment responders in a milder form than was initially present. Conclusions Antidepressants may influence all symptoms of dPD, including those which share great overlap with the physical disease process. Additional research regarding adjunctive interventions is needed to help optimize the management of dPD. PMID:20808132
Chechlacz, Magdalena; Rotshtein, Pia; Humphreys, Glyn W.
Unilateral visual neglect is commonly defined as impaired ability to attend to stimuli presented on the side of visual space contralateral to the brain lesion. However, behavioral analyses indicate that different neglect symptoms can dissociate. The neuroanatomy of the syndrome has been hotly debated. Some groups have argued that the syndrome is linked to posterior parietal cortex lesions, while others report damage within regions including the superior temporal gyrus, insula, and basal ganglia. Several recent neuroimaging studies provide evidence that heterogeneity in the behavioral symptoms of neglect can be matched by variations in the brain lesions, and that some of the discrepancies across earlier findings might have resulted from the use of different neuropsychological tests and/or varied measures within the same task for diagnosing neglect. In this paper, we review the evidence for dissociations between both the symptoms and the neural substrates of unilateral visual neglect, drawing on ALE (anatomic likelihood estimation) meta-analyses of lesion-symptom mapping studies. Specifically, we examine dissociations between neglect symptoms associated with impaired control of attention across space (in an egocentric frame of reference) and within objects (in an allocentric frame of reference). Results of ALE meta-analyses indicated that, while egocentric symptoms are associated with damage within perisylvian network (pre- and postcentral, supramarginal, and superior temporal gyri) and damage within sub-cortical structures, more posterior lesions including the angular, middle temporal, and middle occipital gyri are associated with allocentric symptoms. Furthermore, there was high concurrence in deficits associated with white matter lesions within long association (superior longitudinal, inferior fronto-occipital, and inferior longitudinal fasciculi) and projection (corona radiata and thalamic radiation) pathways, supporting a disconnection account of the syndrome. Using this evidence we argue that different forms of neglect link to both distinct and common patterns of gray and white matter lesions. The findings are discussed in terms of functional accounts of neglect and theoretical models based on computational studies of both normal and impaired attention functions. PMID:22907997
Diefenbach, Gretchen J; Woolley, Stephen B; Goethe, John W
This cross-sectional study assessed the association between self-reported anxiety symptoms and self-reported suicidality among a mixed diagnostic sample of psychiatric outpatients. Data were obtained from chart review of 2,778 outpatients who completed a routine diagnostic clinical interview and a standardized self-report of psychiatric symptoms on admission. Bivariate analyses indicated that those with >or= moderate anxiety symptoms were over three times as likely to report >or= moderate difficulty with suicidality. Self-reported anxiety symptoms were associated with a 2-fold increased likelihood of reporting suicidality after controlling for confounding (demographics, depressive symptoms, and diagnoses). These data are consistent with a growing literature demonstrating an association between anxiety symptoms and suicidality, and suggest that this association is not accounted for by coexisting mood symptoms or diagnoses. A single item, self-report may be a useful screening tool for symptoms that are pertinent to assessment of suicide risk. PMID:19214043
Association between the APOE genotype and psychopathologic symptoms in Alzheimer's disease N between APOE genotype and psychiatric symptomatology in AD have reported contradictory results. Objective: To determine whether APOE genotype predicts incident psychiatric symptom- atology in patients with AD. Methods
... Twitter. What Are the Signs and Symptoms of Hemochromatosis? Hemochromatosis can affect many parts of the body ... the disease don't have signs or symptoms. Hemochromatosis Complications If hemochromatosis isn't found and treated ...
Kouros, Chrystyna D.; Cummings, E. Mark
The present study investigated dynamic, longitudinal associations between depressive symptoms and marital processes. Two hundred ninety-six couples reported on marital satisfaction, marital conflict, and depressive symptoms yearly for three years. Observational measures of marital conflict were also collected. Results suggested that different domains of marital functioning related to husbands’ versus wives’ symptoms. For husbands, transactional relations between marital satisfaction and depressive symptoms were identified: high levels of depressive symptoms predicted subsequent decreases in marital satisfaction, and decreased marital satisfaction predicted subsequent elevations in symptoms over time. For wives, high levels of marital conflict predicted subsequent elevations in symptoms over time. Cross-partner results indicated that husbands’ depressive symptoms were also related to subsequent declines in wives’ marital satisfaction. Results are discussed with regard to theoretical perspectives on the marital functioning-depression link and directions for future research are outlined. PMID:21219284
... data collected on 2,171 children with preschool asthma-like symptoms participating the PIAMA study (development study) and 2,877 children with preschool asthma-like symptoms, participating in the multi-ethnic prospective ...
... are some key symptoms linked to TMD. Unusual sounds — Clicking, grinding or popping sounds when you open your mouth are common in ... doctor for a final diagnosis. If these symptoms sound familiar, talk to your dentist. He or she ...
Marder, Stephen R; Kirkpatrick, Brian
Recent attention has focused on negative symptoms as a target for new therapeutic approaches including pharmacological agents, medical devices, and psychosocial treatments. Each of these approaches requires an instrument for measuring the severity of negative symptoms as well as changes in severity over time. The instrument selected should provide coverage for the domains of negative symptoms; it should be sensitive to change; it should be reliable and relatively brief; and it should be useful for large international trials. These criteria were used to evaluate a number of older instruments including the Schedule for the Assessment of Negative Symptoms (SANS), the Positive and Negative Symptoms Scale (PANSS), and the Negative Symptom Assessment Scale (NSA). Two newer scales, the Brief Negative Symptom Scale (BNSS) and the Clinical Assessment Interview for Negative Symptoms (CAINS) were developed following a National Institute of Mental Health consensus meeting and addressed some of the shortcomings of earlier instruments. PMID:24275698
Wenzel, S L; Andersen, R M; Gifford, D S; Gelberg, L
Information is lacking on homeless women's gynecological symptoms and use of medical care for symptoms. This paper documents and explains gynecological symptoms and conditions and use of medical care in a probability sample of 974 reproductive-age (15-44) homeless women. Two-thirds of women reported symptoms during the previous year; 71 percent of those received medical care for their gynecological symptoms. Pregnancy, drug dependence, more episodes of homelessness, and general physical health symptoms were positively associated with a number of gynecological symptoms. Gynecological symptoms, younger age, better perceived health, and insurance coverage were positively associated with medical care; women reporting recent drug use and rape received less care. These findings support the importance of medical care and other treatment and support services for homeless women, including expanded care during pregnancy and substance abuse treatment. Health insurance coverage and an interruption in the cycle of homelessness also appear vital to women's health. PMID:11475550
... Twitter. What Are the Signs and Symptoms of Pneumonia? The signs and symptoms of pneumonia vary from ... have sudden changes in mental awareness. Complications of Pneumonia Often, people who have pneumonia can be successfully ...
Dianat, Iman; Salimi, Arezou
The working conditions and the prevalence of self-reported musculoskeletal symptoms among 180 Iranian hand-sewn shoe workers were evaluated in this cross-sectional study. Data were collected using both questionnaire (for assessing musculoskeletal symptoms and associated risk factors) and direct observations of posture (by the Rapid Upper Limb Assessment [RULA] method). The prevalence and severity of symptoms was very high among the study population. The mean RULA grand score of 6.2 indicates that in most cases the workers' postures at their workstations need to be investigated and some changes are required immediately. Multiple logistic regression models indicated that the job experience, daily working hours, duration of continuous work without breaks, feeling pressure due to work and working postures were significantly associated with musculoskeletal symptoms of different body regions. The results are discussed in terms of their implications for hand-sewing tasks. These findings can help to better understand the working conditions of those jobs involving hand-sewing operation and highlight the potential for ergonomic interventions to reduce musculoskeletal symptoms among these working groups. PMID:24588329
Robert A. Kinsman; Enrique Fernandez; Marsha Schocket; Jerald F. Dirks; Nicholas A. Covino
Subjective symptoms and experiences were explored within a group of 146 severe, chronic bronchitis and emphysema patients. Eighty-nine symptoms and experiences, derived from initial interviews with 29 patients, were rated according to the frequency of occurrence during breathing difficulties. Key cluster analyses were used to derive a Bronchitis-Emphysema Symptom Checklist (BESC) measuring 11 symptom categories: Helplessness-Hopelessness, Decathexis, Fatigue, Poor Memory,
Wei-Chung Mao; Wayne A. Bardwell; Joel E. Dimsdale; Jacqueline M. Major
Previous studies of coping, hostility, and depressive symptoms have highlighted the significant relations between all possible\\u000a pairs of these 3 variables. To more completely explore the nature of depressive symptoms, we link them all together in this\\u000a study by testing a coping?hostility?depressive symptoms path model.\\u000a \\u000a One hundred forty participants completed psychological questionnaires measuring coping strategies, hostility, and depressive\\u000a symptoms. While
Candace Offutt; J. Michael Lacroix
This study examined the relationship between the Type A Behavior Pattern and reporting of a constellation of physical symptoms related to respiratory infections using a prospective design. The results indicate that Types A and B students did not differ significantly in their reports of the frequency or severity of the constellation of symptoms or of individual symptoms over an 87-day
Leonard A. Jason; Stephanie L. Taylor; Sharon Johnson; Stephen E. Goldston; Doreen Salina; Peter Bishop; Lynne Wagner
Chronic Fatigue Syndrome is an illness that is characterized by debilitating fatigue and a group of other related symptoms. Few epidemiological studies have been conducte4 and none have focused on a nursing population. The present study is the first to assess the prevalence of Chronic Fatigue Syndromerelated symptoms in a sample of nurses. Demographic characteristics, symptoms, and possible prevalence rates
Claire Infante-Rivard; Marie Dumont; Jacques Montplaisir
Nurses and nursing aides (n = 418) currently working on a regular evening or day schedule were compared in terms of sleep disorder symptoms. The relationship between past nightwork and sleep disorder symptoms was also assessed. The prevalence of individual symptoms varied from 6 to 53%. Evening workers showed a pattern of sleep disorder compatible with sleep deprivation, whereas the
Merritt, Victoria C; Rabinowitz, Amanda R; Arnett, Peter A
The purpose of this study was to evaluate the relationship between personality and symptom reporting at baseline in collegiate athletes. Participants were 759 athletes who completed the Post-Concussion Symptom Scale and NEO-Five Factor Inventory. Results showed that neuroticism and agreeableness personality dimensions were predictive of athletes' symptom reports at baseline. PMID:25649780
Nancy Nainis; Judith A. Paice; Julia Ratner; James H. Wirth; Jerry Lai; Susan Shott
Art therapy has been used in a variety of clinical settings and populations, although few studies have explored its use in cancer symptom control. The specific aim of this study was to determine the effect of a 1-hour art therapy session on pain and other symptoms common to adult cancer inpatients. A quasi-experimental design was used (n=50). The Edmonton Symptom
Pierog, S; Chandavasu, O; Wexler, I
Six infants with dysmorphic features of the fetal alcohol syndrome presented with symptoms of withdrawal from alcohol similar to those observed in adults and animals. Symptoms were characterized by irritability, tremors, spontaneous seizures, opisthotonos, and abdominal distention. A comparison of symptoms is made to animal and withdrawal from ethanol and to the neonatal narcotic withdrawal syndrome. PMID:839382
Jeffrey L. Jackson
Background and purpose: Good communication is an integral part of a healing relationship. Our study's purpose was to explore the relationship between patient-doctor communication about physical symptoms and patient outcomes Methods: Five hundred (500) consecutive adults presenting with physical symptoms were surveyed. Previsit surveys assessed for patient symptom characteristics, illness worry, stress, expectations, functional status (MOS SF-6), and mental disorders
Wu, Yelena P.; Selig, James P.; Roberts, Michael C.; Steele, Ric G.
The vast majority of new mothers experience at least some depressive symptoms. Postpartum maternal depressive symptoms can greatly influence children's outcomes (e.g., emotional, cognitive, language, and social development). However, there have been relatively few longitudinal studies of how maternal depressive symptoms may influence children's…
Neil A Rector; Aaron T Beck; Neal Stolar
Recent reports of improvement in the negative symptoms of schizophrenia following targeted cognitive interventions have prompted interest in the cognitive underpinnings of these symptoms. This review integrates current experimental research with the phenomenological accounts of patients participating in cognitive therapy for these specific symptoms. We propose that, in addition to the well-established role of neurobiological factors in their development and
Brodal, Gerth StÃ¸lting
) Hver gruppe fÃ¥r en terning af instruktoren. UdfÃ¸r 100 skridt af nedenstÃ¥ende RandomWalk pÃ¥ grafen, som for at lÃ¸se de fÃ¸lgende Ã¸velser er markeret med gult. BemÃ¦rk at der er to worksheets: Et med grafen og et med,1. sandsynlighed 0,0 0,1 0,2 0,3 0,4 0,5 0,6 0,7 0,8 0,9 1,0 # skridt b) Gentag ovenstÃ¥ende beregning for grafen
Iliadis, S I; Koulouris, P; Gingnell, M; Sylvén, S M; Sundström-Poromaa, I; Ekselius, L; Papadopoulos, F C; Skalkidou, A
Postpartum depression (PPD) is a common childbirth complication, affecting 10-15 % of newly delivered mothers. This study aims to assess the association between personality factors and PPD. All pregnant women during the period September 2009 to September 2010, undergoing a routine ultrasound at Uppsala University Hospital, were invited to participate in the BASIC study, a prospective study designed to investigate maternal well-being. Depressive symptoms were assessed with the Edinburgh Postnatal Depression Scale (EPDS) while the Depression Self-Rating Scale (DSRS) was used as a diagnostic tool for major depression. Personality traits were evaluated using the Swedish Universities Scale of Personality (SSP). One thousand thirty-seven non-depressed pregnant women were included in the study. Non-depressed women reporting high levels of neuroticism in late pregnancy were at high risk of developing postpartum depressive symptoms (PPDSs) at 6 weeks and 6 months after delivery, even after adjustment for confounders (adjusted odds ratio (aOR)?=?3.4, 95 % confidence interval (CI) 1.8-6.5 and adjusted odds ratio (aOR)?=?3.9, 95 % CI 1.9-7.9). The same was true for a DSRS-based diagnosis of major depression at 6 months postpartum. Somatic trait anxiety and psychic trait anxiety were associated with increased risk for PPDS at 6 weeks (aOR?=?2.1, 95 % CI 1.2-3.5 and aOR?=?1.9, 95 % CI 1.1-3.1), while high scores of mistrust were associated with a twofold increased risk for PPDS at 6 months postpartum (aOR 1.9, 95 % CI 1.1-3.4). Non-depressed pregnant women with high neuroticism scores have an almost fourfold increased risk to develop depressive symptoms postpartum, and the association remains robust even after controlling for most known confounders. Clinically, this could be of importance for health care professionals working with pregnant and newly delivered women. PMID:25369905
Lotzmann, U; Kobes, L W
Complaints in the otolaryngologic region, that cannot be referred to an otolaryngological pathologic process, are often caused by or combined with craniomandibular dysfunctions. As a rule these complaints are not the result of direct mechanical irritation of the articular tissues, but the effect of neuromuscular incoordination and spasms. Consequently the term "Costen's syndrome" is obsolete and should be used no more. In many cases the interaction of otolaryngological symptoms and craniomandibular disorders can only be proved ex iuvantibus. Occlusal equilibration combined with physical and physiotherapeutic treatment are approved methods to normalize neuromuscular function and eliminate muscle tension and pain. PMID:1817653
Wakita, Takafumi; Otani, Koji; Onishi, Yoshihiro; Fukuhara, Shunichi; Kikuchi, Shin-ichi; Konno, Shin-ichi
Study Design. Cross-sectional study. Objectives. To test the validity and responsiveness of the lumbar spinal stenosis (LSS)–specific symptom scale (FLS-25 [Fukushima LSS Scale 25]). Summary of Background Data. The FLS-25, a self-administered questionnaire designed to comprehensively cover various symptoms of LSS, has been developed to address the need to measure symptoms specific to this disorder. Methods. One hundred sixty-seven patients with confirmed LSS who required conservative therapy were asked to complete a questionnaire including questions regarding walking capacity and the FLS-25. These patients also underwent a lumbar extension test and a walking stress test, which are stress tests designed to objectively evaluate LSS symptoms, to measure standing time, walking distance, and walking time. Relationship between the FLS-25 scores and these external standards was analyzed to evaluate the criterion validity of the FLS-25. The patients underwent the same evaluations after 8 weeks of conservative therapy. The relationship between changes from baseline to week 8 in FLS-25 scores and changes in the 3 external standards was analyzed to evaluate the responsiveness of the FLS-25. Results. The distribution of FLS-25 scores among patients was symmetric, and there were no ceiling or floor effects. FLS-25 scores increased as self-reported walking capacity decreased (P = 0.006). The mean standing time in the lumbar extension test was 165 (SD = 109) seconds, and FLS-25 scores increased as standing time decreased (P = 0.003). In the walking stress test, mean walking distance and mean walking time were 213 (SD = 154) m and 236 (SD = 114) seconds. FLS-25 scores increased as walking distance (P = 0.002) and walking time (P = 0.054) decreased. Changes from baseline to week 8 in FLS-25 scores correlated with changes in the stress test standing time (P = 0.014), walking distance (P < 0.001), and walking time (P < 0.001). Conclusion. The criterion validity and responsiveness of the FLS-25 were confirmed. The use of FLS-25 in clinical and investigational settings is warranted to monitor patients and evaluate therapeutic efficacy. Level of Evidence: 3 PMID:25365718
Ridderskamp, D; Zellner, M
This study checked whether the prevalence of hypogonadal symptoms [measured using the Aging Males' Symptoms Scale (AMSS)] after radical prostatectomy can give information about the prevalence of hypogonadism in this group of patients. Distribution of the level of complaints (no, mild, moderate or severe) on the AMSS after radical prostatectomy (n=576) was analyzed in all patients (G) and stratified by the point in time of data collection [surgery to AMSS less (K1) and more than 1 year (K2)].The total score shows more patients with mild and moderate symptoms in G, K1, and K2 compared with the control (G 57.6 and 23.4%, K1 59.1 and 22.4%, K2 40 and 35.6% vs 36.5 and 11.2%). In the somatic score G and K1 show 2.4% (G) and 1.7% (K1) less patients with no and 1.5% (G) and 0.9% (K1) less patients with little complaints compared with the control; 2.6% (G) and 1.8% (K1) more patients state moderate and 1.2% (G) and 0.8% (K1) more severe complaints. K2 shows fewer patients with no and mild (22.2 and 31.1% vs 33.3 and 39.3%) and more with moderate and severe complaints (33.3 and 13.3% vs 21.0 and 6.4%) compared with the control. In the psychological score patients in G and K1 state less mild complaints (G 33.9%, K1 32.8% vs 41.8%), more patients state no complaints (G 45.8%, K1 47.3% vs 43.6%) as well as moderate and severe complaints (G 12.8%, K1 12.8% vs 10.9% and G 7.5%, K1 7.2% vs 3.7 %) compared with the control. K2 shows more complaints of all levels compared with the control (mild 46.7 vs 41.8%, moderate 13.3 vs 10.9%, and severe 11.1 vs 3.7%). In the sexual score all groups of patients show significantly more severe complaints (G 89.6%, K1 89.5%, K2 91.1% vs 6.1%).Multiple factors influenced by surgery and diagnosis of cancer which are independent of hormonal effects make distribution of hypogonadal symptoms on the AMSS not suitable to give information about the prevalence of hypogonadism after radical prostatectomy. An analysis of serum testosterone seems to be essential. PMID:21424426
Krause, Miriam S; Nakajima, Steven T
This article focuses on the cause, pathophysiology, differential diagnosis of, and treatment options for vasomotor symptoms. In addition, it summarizes important points for health care providers caring for perimenopausal and postmenopausal women with regard to health maintenance, osteoporosis, cardiovascular disease, and vaginal atrophy. Treatment options for hot flashes with variable effectiveness include systemic hormone therapy (estrogen/progestogen), nonhormonal pharmacologic therapies (selective serotonin reuptake inhibitors, selective norepinephrine reuptake inhibitors, clonidine, gabapentin), and nonpharmacologic therapy options (behavioral changes, acupuncture). Risks and benefits as well as contraindications for hormone therapy are further discussed. PMID:25681847
Surasak Taneepanichskul; Unnop Jaisamrarn; Vorapong Phupong
Objective To evaluate the effect of oral contraception formulation with drospirenone (Yasmin) on premenstrual symptoms.\\u000a \\u000a \\u000a \\u000a Materials and methods An open-label non-comparative clinical trial was conducted. One hundred women who desired oral contraception for at least\\u000a 6 months were recruited. The subjects received a blister pack which contained 21 tablets of 3 mg drospirenone\\/30 ?g ethinyl\\u000a estradiol for the first four cycles (1 cycle = 28 days). Cycle-5 and
Costa, Carla Fabiane da; Polanski, Jose Fernando
Introduction?Wegener granulomatosis is a systemic vasculitis affecting small and medium-sized vessels of the upper and lower respiratory tract and kidneys. Objective?To describe a case of Wegener disease with atypical manifestation. Resumed Report?We describe the case of a 50-year-old woman with chronic otitis media and sensorineural hearing loss as the primary symptoms, without other manifestations. Conclusion?In cases of acute ear manifestations with or without hearing loss and with poor response to usual treatments, Wegener granulomatosis should be included among the possible etiologies. After adequate diagnoses and treatment of this rare disease, there was favorable evolution.
Costa, Carla Fabiane da; Polanski, Jose Fernando
Introduction?Wegener granulomatosis is a systemic vasculitis affecting small and medium-sized vessels of the upper and lower respiratory tract and kidneys. Objective?To describe a case of Wegener disease with atypical manifestation. Resumed Report?We describe the case of a 50-year-old woman with chronic otitis media and sensorineural hearing loss as the primary symptoms, without other manifestations. Conclusion?In cases of acute ear manifestations with or without hearing loss and with poor response to usual treatments, Wegener granulomatosis should be included among the possible etiologies. After adequate diagnoses and treatment of this rare disease, there was favorable evolution. PMID:26157503
Glenn S Gerber; Gregory P Zagaja; Gregory T Bales; Gerald W Chodak; Barbara A Contreras
Objectives. To assess the effects of saw palmetto on voiding symptoms and urodynamic parameters in men with lower urinary tract symptoms (LUTS) presumed secondary to benign prostatic hyperplasia (BPH).Methods. Fifty men with previously untreated LUTS and a minimum International Prostate Symptom Score (IPSS) of 10 or greater were treated with a commercially available form of saw palmetto (160 mg twice
Kassam-Adams, Nancy; Marsac, Meghan L.; Cirilli, Carla
Objective: To examine the factor structure of posttraumatic stress disorder (PTSD) symptoms in children and adolescents who have experienced an acute single-incident trauma, associations between PTSD symptom clusters and functional impairment, and the specificity of PTSD symptoms in relation to depression and general distress. Method: Examined…
Brakoulias, Vlasios; Starcevic, Vladan; Berle, David; Sammut, Peter; Milicevic, Denise; Moses, Karen; Hannan, Anthony; Martin, Andrew
Attempts to explain the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) have resulted in three to six OCD symptom dimensions. This study aimed to clarify the nature of these symptom dimensions using a self-report instrument (Vancouver Obsessional Compulsive Inventory [VOCI]) in addition to the clinician-rated Yale-Brown Obsessive Compulsive Scale-Symptom Checklist (YBOCS-SC). Participants (N = 154) were recruited to a study designed to specifically assess OCD symptom dimensions. Symptoms assessed via the YBOCS-SC and the VOCI were subjected to principal components analysis (PCA). Linear regression was used to assess the relationship between the YBOCS-SC-derived symptom dimensions and the VOCI symptom subscales. PCA of the YBOCS-SC and the VOCI revealed five OCD symptom dimensions that explained 68% and 60% of the variance, respectively. The results also supported a distinction between the doubt/checking symptom dimension and the unacceptable/taboo thoughts dimension that includes mental rituals. The YBOCS-SC-derived symptom components were predicted by their respective VOCI symptom subscale scores. PMID:23686154
Vasomotor and vaginal symptoms are cardinal symptoms of menopause. Vasomotor symptoms can be particularly troubling to women and are the most commonly reported menopausal symptoms, with a reported prevalence of 50-82% among U.S. women who experience natural menopause (1, 2). The occurrence of vasomotor symptoms increases during the transition to menopause and peaks approximately 1 year after the final menstrual period (3-5). The purpose of this document is to provide evidence-based guidelines for the treatment of vasomotor and vaginal symptoms related to natural and surgical menopause. (Treatment of menopausal symptoms in cancer survivors is discussed in the American College of Obstetricians and Gynecologists' Practice Bulletin Number 126, Management of Gynecologic Issues in Women With Breast Cancer.). PMID:24463691
Potter, Carrie M; Kinner, Dina G; Tellez, Marisol; Ismail, Amid I; Heimberg, Richard G
The occurrence of panic symptoms in various anxiety disorders has been associated with more severely impaired and difficult-to-treat cases, but this has not been investigated in dental phobia. We examined the clinical implications of panic symptoms related to sub-clinical and clinically significant dental phobia. The sample consisted of 61 patients at a university dental clinic who endorsed symptoms of dental phobia, 25 of whom met criteria for a formal diagnosis of dental phobia. Participants with dental phobia endorsed more panic symptoms than did those with sub-clinical dental phobia. In the total sample, greater endorsement of panic symptoms was associated with higher dental anxiety, more avoidance of dental procedures, and poorer oral health-related quality of life. Among those with dental phobia, certain panic symptoms exhibited associations with specific anxiety-eliciting dental procedures. Panic symptoms may serve as indicators of clinically significant dental phobia and the need for augmented treatment. PMID:25173979
In addition to the primary symptoms that distinguish one disorder from the next, clinicians have identified, yet largely overlooked, another set of symptoms that appear across many disorders, termed secondary symptoms. In the emerging era of systems neuroscience, which highlights that many disorders share common deficits in global network features, the nonspecific nature of secondary symptoms should attract attention. Herein we provide a scholarly review of the literature on a subset of secondary symptoms––sensory and motor. We demonstrate that their pattern of appearance––across a wide range of psychopathologies, much before the full-blown disorder appears, and in healthy individuals who display a variety of negative symptoms––resembles the pattern of appearance of network abnormalities. We propose that sensory and motor secondary symptoms can be important indicators of underlying network aberrations and thus of vulnerable brain states putting individuals at risk for psychopathology following extreme circumstances. PMID:24063566
Helpman, Liat; Rachamim, Lilach; Aderka, Idan M; Gabai-Daie, Ayala; Schindel-Allon, Inbal; Gilboa-Schechtman, Eva
The applicability of diagnostic criteria of Posttraumatic Stress Disorder to the pediatric population has been a focus of much debate (e.g., Carrion, Weems, Ray, & Reiss, 2002 ), informing changes in the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5). The current study examined the factor structure of posttraumatic distress among adult versus pediatric samples using confirmatory factor analysis. The analysis was performed on the DSM-IV-adherent Posttraumatic Diagnostic Scale (Foa, Cashman, Jaycox, & Perry, 1997 ) and Child Posttraumatic Symptom Scale (Foa, Johnson, Feeny, & Treadwell, 2001 ). The sample included 378 adult and 204 child and adolescent victims of diverse single-event traumas. A series of models based on previous findings and DSM-IV specification were evaluated. A 4-factor model (Intrusions, Avoidance, Dysphoria, and Hyperarousal), similar to the DSM-5 model, best fit the data among adults, and a different 4-factor model (Intrusion, Avodiance, Numbing, and Hyperarousal) best fit the data among children and adolescents. Despite some similarity, the posttraumatic symptom profiles of pediatric and adult samples may differ. These differences are not fully incorporated into the DSM-5, and warrant further examination. PMID:24635582
Ronkainen, Jukka; Agréus, Lars
Gastro-oesophageal reflux disease (GORD) occurs when reflux of gastric contents causes troublesome symptoms and/or complications (the Montreal definition). GORD is a common condition with a substantial economical burden to the community and it has a significant negative effect on health-related quality of life (HRQoL) while endoscopic findings like erosive oesophagitis per se seem to correlate badly with the experienced HRQoL. The prevalence of GORD varies over the world for unknown reasons, but genetic differences, difference in the Helicobacter pylori prevalence and life style factors like obesity might influence. The prevalence is lowest in East Asia (2.5-9.4%) and higher in Mid (7.6-19.4%) and Western Asia (12.5-27.6%). The highest population-based prevalence is reported from Europe (23.7%) and the US (28.8%). GORD seems to be fairly stable over time both in terms of symptoms and erosive oesophagitis, but the prevalence seems to be increasing both in Asia and in the West. PMID:23998972
Whitaker, Katriina L.; Scott, Suzanne E.; Winstanley, Kelly; Macleod, Una; Wardle, Jane
Background Attribution of early cancer symptoms to a non-serious cause may lead to longer diagnostic intervals. We investigated attributions of potential cancer ‘alarm’ and non-alarm symptoms experienced in everyday life in a community sample of adults, without mention of a cancer context. Methods A questionnaire was mailed to 4858 adults (?50 years old, no cancer diagnosis) through primary care, asking about symptom experiences in the past 3 months. The word cancer was not mentioned. Target 'alarm' symptoms, publicised by Cancer Research UK, were embedded in a longer symptom list. For each symptom experienced, respondents were asked for their attribution (‘what do you think caused it'), concern about seriousness (‘not at all’ to ‘extremely’), and help-seeking (‘did you contact a doctor about it’: Yes/No). Results The response rate was 35% (n?=?1724). Over half the respondents (915/1724; 53%) had experienced an ‘alarm’ symptom, and 20 (2%) cited cancer as a possible cause. Cancer attributions were highest for ‘unexplained lump’; 7% (6/87). Cancer attributions were lowest for ‘unexplained weight loss’ (0/47). A higher proportion (375/1638; 23%) were concerned their symptom might be ‘serious’, ranging from 12% (13/112) for change in a mole to 41% (100/247) for unexplained pain. Just over half had contacted their doctor about their symptom (59%), although this varied by symptom. Alarm symptoms were appraised as more serious than non-alarm symptoms, and were more likely to trigger help-seeking. Conclusions Consistent with retrospective reports from cancer patients, ‘alarm’ symptoms experienced in daily life were rarely attributed to cancer. These results have implications for understanding how people appraise and act on symptoms that could be early warning signs of cancer. PMID:25461959
Graham, Kyran T.; Martin-Iverson, Mathew T.; Holmes, Nicholas P.; Jablensky, Assen; Waters, Flavie
Individuals with schizophrenia, particularly those with passivity symptoms, may not feel in control of their actions, believing them to be controlled by external agents. Cognitive operations that contribute to these symptoms may include abnormal processing in agency as well as body representations that deal with body schema and body image. However, these operations in schizophrenia are not fully understood, and the questions of general versus specific deficits in individuals with different symptom profiles remain unanswered. Using the projected-hand illusion (a digital video version of the rubber-hand illusion) with synchronous and asynchronous stroking (500?ms delay), and a hand laterality judgment task, we assessed sense of agency, body image, and body schema in 53 people with clinically stable schizophrenia (with a current, past, and no history of passivity symptoms) and 48 healthy controls. The results revealed a stable trait in schizophrenia with no difference between clinical subgroups (sense of agency) and some quantitative (specific) differences depending on the passivity symptom profile (body image and body schema). Specifically, a reduced sense of self-agency was a common feature of all clinical subgroups. However, subgroup comparisons showed that individuals with passivity symptoms (both current and past) had significantly greater deficits on tasks assessing body image and body schema, relative to the other groups. In addition, patients with current passivity symptoms failed to demonstrate the normal reduction in body illusion typically seen with a 500?ms delay in visual feedback (asynchronous condition), suggesting internal timing problems. Altogether, the results underscore self-abnormalities in schizophrenia, provide evidence for both trait abnormalities and state changes specific to passivity symptoms, and point to a role for internal timing deficits as a mechanistic explanation for external cues becoming a possible source of self-body input. PMID:25309460
Lange, Rael T; Brickell, Tracey A; Kennedy, Jan E; Bailie, Jason M; Sills, Cheryl; Asmussen, Sarah; Amador, Ricardo; Dilay, Angelica; Ivins, Brian; French, Louis M
The purpose of this study was to identify factors that are predictive of, or associated with, high endorsement of postconcussion and posttraumatic stress symptoms following military-related traumatic brain injury (TBI). Participants were 1,600 U.S. service members (age: M = 27.1, SD = 7.1; 95.4% male) who had sustained a mild-to-moderate TBI and who had been evaluated by the Defense and Veterans Brain Injury Center at one of six military medical centers. Twenty-two factors were examined that included demographic, injury circumstances/severity, treatment/evaluation, and psychological/physical variables. Four factors were statistically and meaningfully associated with clinically elevated postconcussion symptoms: (i) low bodily injury severity, (ii) posttraumatic stress, (iii) depression, and (iv) military operation where wounded (p < .001, 43.2% variance). The combination of depression and posttraumatic stress symptoms accounted for the vast majority of unique variance (41.5%) and were strongly associated with, and predictive of, clinically elevated postconcussion symptoms [range: odds ratios (OR) = 4.24-7.75; relative risk (RR) = 2.28-2.51]. Five factors were statistically and meaningfully associated with clinically elevated posttraumatic stress symptoms: (i) low bodily injury severity, (ii) depression, (iii) a longer time from injury to evaluation, (iv) military operation where wounded, and (v) current auditory deficits (p < .001; 65.6% variance accounted for). Depression alone accounted for the vast majority of unique variance (60.0%) and was strongly associated with, and predictive of, clinically elevated posttraumatic stress symptoms (OR = 38.78; RR = 4.63). There was a very clear, strong, and clinically meaningful association between depression, posttraumatic stress, and postconcussion symptoms in this sample. Brain injury severity, however, was not associated with symptom reporting following TBI. PMID:24723461
Bai, Jiayue; Zhang, Wei; Zhang, Xin; Sun, Yapeng; Ding, Wenyuan; Shen, Yong
Background The aim of this study was to analyze treatment outcomes and morbidity of contralateral neurological symptom in patients after TLIF surgery and to explore its possible causes. Material/Methods A retrospective study was conducted involving a total of 476 patients who underwent TILF from 2009 to 2012 in our hospital. These cases were divided into a symptomatic group (Group S) and a non-symptomatic group. The differences in contralateral foramen area and disc-height index(DHI) before and after surgery were compared between Group S and a random sample of 40 cases of non-symptomatic group patients (group N). In addition, according to whether the patient underwent second surgery, Group S patients were further divided into a transient neurologic symptoms group (Group T) and an operations exploration group (Group O). The time of symptom appearance, duration, and symptomatic severity (JOA VAS score) were compared between Group T and O. Results Among the 476 patients, 18 had postoperative contralateral neurological symptoms; thus, the morbidity was 3.7815%. The indicators in Group S were lower than in Group N in the differences in contralateral foramen area and disc-height index(DHI) before and after surgery (p<0.05). Five patients (Group O) in Group S had second surgery because of invalid conservative treatment. The surgical exploration rate was 1.0504%. Compared with Group T, the symptoms of Group O patients appeared earlier, persisted longer, and were more serious (p<0.05). Conclusions Contralateral neurological symptom is a potential complication after TLIF, and its causes are diverse. Surgical explorations should be conducted early for those patients with the complication who present with obvious nerve damage. PMID:26109143
Bjelanovi?, Vedran; Babi?, Dragan; Oreskovi?, Slavko; Tomi?, Vajdana; Martinac, Marko; Juras, Josip
Pregnancy is followed by many physiologic, organic and psychological changes and disorders, which can become more serious in pregnancy followed by complications, especially in women with pathological conditions during pregnancy. The purpose of this study was to find out and analyze the prevalence and intensity of psychological disorders in women with pathological conditions during pregnancy and compare it with conditions in pregnant women who had normal development of pregnancy. The research is approved by the Ethical committee of the Mostar University Hospital Center, and it was made in accordance with Helsinki declaration and good clinical practices. The research conducted section for pathology of pregnancy of Department for gynecology and obstetrics of the Mostar University Hospital Center. It included 82 pregnant women with disorders in pregnancy developement and control group consisted of pregnant women who had normal development of pregnancy. The research work was conducted from September 2007 to August 2008 in Mostar University Hospital Center. Pregnant women had Standard and laboratory tests, Ultrasound. CTG examinations were done for all pregnant women and additional tests for those women with complications during pregnancy. Pregnant women completed sociobiographical, obstetrical-clinical and psychological SCL 90-R questionnaire. Pregnant women with pathological pregnancy exibited significantly more psychological symptoms in comparison to pregnant women with normal pregnancy (p < 0.001 to p = 0.004). Frequency and intensity of psychical symptoms and disorders statisticly are more characteristic in pathological pregnancy (61%/40.6%). The statistical data indicate a significantly higher score of psychological disorders in those pregnant women with primary school education (p = 0.050), those who take more than 60% carbohydrates (p = 0.001), those with pathological CTG records (p < 0.001), those with pathological ultrasound results (p < 0.001 to 0.216) and those pregnant women with medium obesity and obesity (p = 0.046). Body mass index (BMI) during normal pregnancy development is lower (p = 0.002) but the levels of glucose, triglycerides, cholesterol, HDL and LDL in blood are higher Blood pressure in pregnant women with pathological pregnancy was statistically significantly higher (p < 0.001). Diagnostic criteria for the metabolic syndrome were found in 19 pregnant women with the pathological pregnancy. Statistically, in those women, a significantly higher appearance of psychological symptoms and disorders was observed in comparison to the pregnant women without metabolic syndrome (p < 0.001). The research has shown that 87.8% from all pregnant women included in this study have been hospitalized due to premature birth, hypertensive disorders, and diabetes in pregnancy, and also due to bleeding in the second and third trimester of pregnancy. PMID:23213943
Jens Teilberg Søndergaard
Immanuel Kant lancerede med sin korte tekst Til den evige fred i 1795 udtrykket kosmopolitisk ret. I dag—200 år senere—ser en række politologiske teoretikere den kantianske kosmopolitanisme som den medicin, der skal helbrede verdenen for de dårligdomme, globaliseringen har påført den. I denne artikel argumenteres for, at selvom den kantianske kosmopolitanisme kan skabe øget fred og sikkerhed, så rummer den
SQUID DETECTION OF EPR IN DILUTE CMN* R.V.Chamberlin, L.A. Moberly and O.G. Symko Dept. of Physios, University of Utah, Salt Lake City, Utah 84112, U.S.A. Abstract.- We demonstrate the applicability of SQUID-lattice relaxation times. The very high sensitivity of a SQUID magne- tometer makes it an ideal instrument for every
PORTLAND STATE UNIVERSITY PLEASE SUBMIT A SINGLE TYPED OR PRINTED COPY 9/00 PSU/OGS GO-11GC from another institution is proposed. The GO-11GC must be submitted and approved before the Graduate Certificate Program Completion Form can be approved. Approval of the GO-11GC early in the student's program
Brodal, Gerth StÃ¸lting
Opgave 17 a) Formuler fÃ¸lgende spil som et transitionssystem: Man har en krukke med sorte og hvide den sidste kugle? b) Formuler fÃ¸lgende spil som et transitionssystem. Et spillebrÃ¦t har udseendet 1 2
1 Rungende malm og råbende roser.* En anmeldelse af Jakob Wolf (2004): Rosens Råb. Intelligent design i naturen. Opgør med Darwinismen. København: Forlaget Anis. Af Claus Emmeche Teologen Jakob Wolf klassiske kreationisme, tager den bibelske skabelsesberetning bogstaveligt. Men Wolf gør en del ud af
Romera, Irene; Pérez, Víctor; Quail, Deborah; Berggren, Lovisa; Lenox-Smith, Alan; Gilaberte, Inmaculada
The aim of treatment of depression is remission of symptoms and functioning. Although there is a relationship between remission of symptoms and remission of functioning, it is not known how individual residual symptoms are related to functioning. Here we report a post-hoc analysis of two studies which treated depressed patients with duloxetine in an open fashion for 10-12 weeks. We evaluated the association of individual residual symptoms and functional impairment in patients who remitted or partially remitted after acute treatment. Logistic regression was used to investigate residual symptoms associated with functional impairment at endpoint. Our results suggest that in partial remitters, the only residual symptom associated with a reduction in the risk of having impaired function was the resolution of painful physical symptoms (PPS). In patients who remitted, the presence of residual core mood symptoms (CMS), particularly in patients without any anxiety, predicted impaired functioning. The resolution of PPS in the presence of residual CMS was associated with less risk of impaired functioning. Our results contribute to understand better the role of specific residual symptoms on functional impairment. To achieve normal functioning, intervention on specific residual symptoms is recommended. PMID:25149132
Ayub, Muhammad; Saeed, Khalid; Kingdon, David; Naeem, Farooq
Psychotic symptoms are more common in general population than validated diagnosis of psychosis. There is evidence to suggest that these symptoms, hallucinations, paranoia, elated mood, thought insertion, are part of a spectrum of psychosis and may have association with the same risk factors that determine development of psychosis. These symptoms have an association with exposure to psychological trauma, post-traumatic stress disorder, anxiety and depression. The aim of this study was to explore the prevalence of psychotic symptoms in the population affected by a natural disaster, earthquake in this case and possible correlates of these symptoms. We conducted a cross-sectional survey of a population sample affected by the disaster, comprising of 1,291 individuals, 18 months after 2005 earthquake in Northern Pakistan and Kashmir to look at the prevalence of these symptoms and their correlates. Screening Instrument for Traumatic Stress in Earthquake Survivors and Self-Reporting Questionnaire and Psychosis Screening Questionnaire were used as tools. We examined association between the symptoms of anxiety, depression, PTSD and psychotic symptoms. We performed logistic regression analysis where hallucinations and delusions were dependent variables and demographic and trauma exposure variables were independent variables. The prevalence of psychotic symptoms ranged between 16.8 and 30.4 %. They were directly correlated with symptoms of post-traumatic stress disorder as well as concurrent symptoms of anxiety and depression. Lower level of education had a strong association in all the regression models. For hallucinations, living in a joint family had a negative association and participation in rescue, history of exposure to previous trauma and past psychiatric history had positive association. Paranoia was associated with female gender. Any psychiatric symptom was associated death of a family member, history of past psychiatric illness and living in a tent at the time of interview. Pattern of association of psychotic symptoms is consistent with prior literature and can be understood in the light of stress vulnerability model. PMID:25421792
Prochwicz, Katarzyna; Sobczyk, Artur
The Jerusalem syndrome is an acute psychotic state observed in tourists and pilgrims who visit Jerusalem. The main symptom of this disorder is identification with a character from the Bible and exhibiting behaviours which seems to be typical for this character. The article presents an overview of cultural and demographic factors associated with the appearance of the Jerusalem syndrome. Three main categories of the syndrome were identified with special focus on the category unconjoined to previous psychopathology which can be described as the 'pure' form of the Jerusalem syndrome. The main diagnostic criteria for the 'pure' type and the sequence of seven clinical stages of the Jerusalem syndrome were described. The article contains a review of the hypothesis about the causes of Jerusalem syndrome with special attention given to the role of places of particular meaning for religious tradition. PMID:21714216
Sádaba Díaz de Rada, B; Azanza Perea, J R; Gomez-Guiu Hormigos, A
Bilastine is a potent inhibitor of the histamine H1 receptor. It was recently approved in 28 countries of the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria in adults and children older than 12 years. Data from preclinical studies confirmed its selectivity for the histamine H1 receptor over other receptors, and demonstrated antihistaminic and antiallergic properties in vivo. Studies in healthy volunteers and patients have shown that bilastine does not affect driving ability, cardiac conduction or alertness. Bilastine has demonstrated a good safety profile, without serious adverse effects or antimuscarinic effects in clinical trials. There were no significant changes in laboratory tests, electrocardiograms or vital signs. In clinical studies, oral treatment with bilastine 20 mg once daily improved allergic rhinitis with greater efficacy than placebo and comparable to cetirizine and desloratadine. Bilastine 20 mg was more effective than placebo and equivalent to levocetirizine in chronic urticaria, relieving symptoms, improving quality of life and controlling sleep disorders. PMID:21573249
Talih, Farid; Ghossoub, Elias
It is well documented in the literature that noradrenergic pathways are key in the manifestation of opioid withdrawal symptoms, which is why clonidine is used as an off-label agent in opioid detoxification regimens given its anti-sympathetic properties. Moxonidine is a selective I1-imidazoline receptor agonist, similar to clonidine but with no ?2-adrenergic agonist activity and subsequently fewer side effects. We report the case of a 33-year-old woman with a 15-year history of tramadol use who was admitted voluntarily for detoxification. She was started on moxonidine and had an uneventful detoxification. Two months after discharge, the patient maintained tramadol abstinence with good tolerability to moxonidine. To the best of our knowledge, this has not been previously reported in the medical literature. PMID:26156837
This is a case study presented by the University of Pittsburgh Department of Pathology which presents a "37-year-old white female who was in excellent health until three years prior, when she developed flu-like symptoms." Visitors are given an extensive patient history along with pathologic findings, including images, and are given the opportunity to diagnose the patient. A "Final Diagnosis" section provides a discussion of the findings as well as references. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in cardiovascular pathology.
Chapman, Thomas P; Hadley, Gina; Fratter, Carl; Cullen, Sue N; Bax, Bridget E; Bain, Murray D; Sapsford, Robert A; Poulton, Joanna; Travis, Simon P
Defects in mitochondrial function are increasingly recognised as central to the pathogenesis of many diseases, both inherited and acquired. Many of these mitochondrial defects arise from abnormalities in mitochondrial DNA and can result in multisystem disease, with gastrointestinal involvement common. Moreover, mitochondrial disease may present with a range of non-specific symptoms, and thus can be easily misdiagnosed, or even considered to be non-organic. We describe the clinical, histopathological and genetic findings of six patients from three families with gastrointestinal manifestations of mitochondrial disease. In two of the patients, anorexia nervosa was considered as an initial diagnosis. These cases illustrate the challenges of both diagnosing and managing mitochondrial disease and highlight two important but poorly understood aspects, the clinical and the genetic. The pathophysiology of gastrointestinal involvement in mitochondrial disease is discussed and emerging treatments are described. Finally, we provide a checklist of investigations for the gastroenterologist when mitochondrial disease is suspected. PMID:23768727
Background Assessment and management of symptoms is a main task in primary care. Symptoms may be defined as 'any subjective evidence of a health problem as perceived by the patient’. In other words, symptoms do not appear as such; symptoms are rather the result of an interpretation process. We aim to discuss different perspectives on symptom interpretation as presented in the disciplines of biomedicine, psychology and anthropology and the possible implications for our understanding of research on symptoms in relation to prevalence and diagnosis in the general population and in primary care. Discussion Symptom experiences are embedded in a complex interplay between biological, psychological and cultural factors. From a biomedical perspective, symptoms are seen as possible indicators of disease and are characterized by parameters related to seriousness (e.g. appearance, severity, impact and temporal aspects). However, such symptom characteristics are rarely unambiguous, but merely indicate disease probability. In addition, the GP’s interpretation of presenting symptoms will also be influenced by other factors. From a psychological perspective, factors affecting interpretation are in focus (e.g. internal frame of reference, attention to sensations, illness perception and susceptibility to suggestion). These individual factors cannot stand alone either, but are influenced by the surroundings. Anthropological research suggests that personal experiences and culture form a continuous feedback relationship which influence when and how sensations are understood as symptoms of disease and acted upon. Summary The different approaches to symptom interpretation imply that we need to be cautious and conscious when interpreting survey findings that are based on symptom prevalence in the general population or in primary care. These findings will reflect a variety of interpretations of sensations, which are not equivalent to expressions of underlying disease. Furthermore, if diagnosis of disease is based exclusively on the presence of specific symptom characteristics, we may risk reinforcing a dualistic approach, including medicalisation of normal phenomena and devaluation of medically unexplained symptoms. Future research in primary care could gain from exploring symptoms as a generic phenomenon and raised awareness of symptom complexity. PMID:24188544
Nadorff, Michael R; Nazem, Sarra; Fiske, Amy
Duration of insomnia symptoms or nightmares was investigated to see if it was related to suicide risk independent of current insomnia symptoms, nightmares, anxiety symptoms, depressive symptoms, and posttraumatic symptoms. The cross-sectional study involved analyses of survey responses from undergraduate students who endorsed either insomnia symptoms (n = 660) or nightmares (n = 312). Both insomnia symptom and nightmare duration were significantly associated with suicide risk independent of current insomnia symptoms or nightmares, respectively. Relations were also significant after controlling for anxiety symptoms, depressive symptoms, and posttraumatic symptoms. Results suggest that duration of sleep disturbance is relevant when assessing suicide risk. PMID:23278677
Woolridge, Emily; Barton, Simon; Samuel, Jonathon; Osorio, Jess; Dougherty, Andrew; Holdcroft, Anita
Despite the major benefits of antiretroviral therapy on survival during HIV infection, there is an increasing need to manage symptoms and side effects during long-term drug therapy. Cannabis has been reported anecdotally as being beneficial for a number of common symptoms and complications in HIV infections, for example, poor appetite and neuropathy. This study aimed to investigate symptom management with cannabis. Following Ethics Committee approval, HIV-positive individuals attending a large clinic were recruited into an anonymous cross-sectional questionnaire study. Up to one-third (27%, 143/523) reported using cannabis for treating symptoms. Patients reported improved appetite (97%), muscle pain (94%), nausea (93%), anxiety (93%), nerve pain (90%), depression (86%), and paresthesia (85%). Many cannabis users (47%) reported associated memory deterioration. Symptom control using cannabis is widespread in HIV outpatients. A large number of patients reported that cannabis improved symptom control. PMID:15857739
Manfreda, J; Holford-Strevens, V; Cheang, M; Warren, C P
History of acute symptoms (cough, wheezing, shortness of breath, fever, stuffy nose, and skin itching/rash) following exposure to grain dust was obtained from 661 male and 535 female current and former farmers. These symptoms were relatively common: 60% of male and 25% of female farmers reported at least one such symptom on exposure to grain dust. Association of cough, wheezing, shortness of breath, and stuffy nose with skin reactivity and capacity to form IgE is consistent with an allergic nature of these symptoms. Barley and oats dust were perceived as dust most often producing symptoms. On the other hand, grain fever showed a different pattern, i.e., it was not associated with either skin reactivity or total IgE. Smoking might modify the susceptibility to react to grain dust with symptoms. Only those who reported wheezing on exposure to grain dust may have an increased risk to develop chronic airflow obstruction. PMID:3709486
Bob, Petr; Selesova, Petra; Raboch, Jiri; Kukla, Lubomir
Current findings suggest that mother's marital status indicating father's absence or conflicting relationship to father may be specifically related to dissociation and other stress-related symptoms. We have assessed relationships of mother's marital status, dissociative symptoms, and other psychopathological manifestations in a sample of 19 years' old young adults (N = 364) participating in European longitudinal study (European Longitudinal Study of Parenthood and Childhood). The results show clinically significant manifestations of dissociative symptoms in young adult men whose mothers were fatherless and in women whose mothers were re-married. Other psychopathological symptoms did not reach clinically significant manifestations. The results suggest that significant factor related to high level of dissociative symptoms in men growing in fatherless families might be linked with disturbed and conflicting attachment to a father's figure and pathological dependent attachment to mother. In women dissociative symptoms likely are linked to conflicting relationship between mother and daughter associated with stepfather' presence in the family. PMID:25590849
Palapattu, Anuradha G; Kingery, Julie Newman; Ginsburg, Golda S
The present study evaluated gender role theory as an explanation for the observed gender differences in anxiety symptoms among adolescents. Specifically, the relation between gender, gender role orientation (i.e., masculinity and femininity), self-esteem, and anxiety symptoms was examined in a community sample of 114 African Americans aged 14 to 19 (mean age 15.77; 57 girls). Results revealed that masculinity was negatively associated with anxiety symptoms whereas femininity was positively associated with anxiety symptoms. Gender role orientation accounted for unique variance in anxiety scores above biological gender and self-esteem, and self-esteem moderated the relation between femininity (but not masculinity) and overall anxiety symptoms. Consistent with research on children and Caucasians, findings supported gender role theory as a partial explanation for the observed gender disparity in anxiety symptoms among African American adolescents. PMID:16619140
Koskinen, Anni; Penttilä, Matti; Myller, Jyri; Hammarén-Malmi, Sari; Silvola, Juha; Haahtela, Tari; Hytönen, Maija
Background: Endoscopic sinus surgery (ESS) is considered after medical therapy failure of chronic rhinosinusitis (CRS). The balloon sinuplasty dilates the natural ostium without moving mucosa or bone. It still lacks evidence from randomized controlled trials. The aim of this retrospective controlled study was to compare the symptom outcomes after maxillary sinus surgery with either the ESS or the balloon sinuplasty technique. No previous or additional sinonasal operations were accepted. Methods: Two hundred eight patients with CRS without nasal polyps underwent either balloon sinuplasty or ESS. The patients who met with the inclusion criteria (n = 45 in ESS group and n = 40 in balloon group) replied to a questionnaire of history factors, exacerbations, and a visual analog scale (VAS) scoring of the change in symptoms, on average 28 ± 6 (mean ± SD) months postoperatively. Results: The groups were identical in the response rate (64%), patient characteristics, and the improvement in all of the asked symptoms. Patients with CRS-related comorbidity and/or present occupational exposure had a statistically significantly better symptom reduction after ESS than after balloon sinusotomy. Moreover, the balloon sinusotomy group reported a statistically significant higher number of maxillary sinus punctures and antibiotic courses during the last 12 months. Conclusion: ESS might be superior to balloon sinuplasty, especially in patients with risk factors. There is a need to perform more controlled studies on the treatment choices of CRS. PMID:23232189
Tabarki, Brahim; Khalifa, Monia; Yacoub, Moncef; Tlili, Kalthoum; Essoussi, Ahmed S
Children with Crigler-Najjar syndrome type I are at increased risk for neurologic deficits. Cerebellar symptoms are not prominent and appear in adolescent or adult patients with this syndrome. We report a 2-year-old female with Crigler-Najjar syndrome type I who presented severe cerebellar symptoms revealing bilirubin encephalopathy. The patient improved slowly with the duration of phototherapy. Cerebellar symptoms can be the initial manifestation of kernicterus in children with Crigler-Najjar syndrome type I. PMID:12393137
Brahim Tabarki; Monia Khalifa; Moncef Yacoub; Kalthoum Tlili; Ahmed S Essoussi
Children with Crigler-Najjar syndrome type I are at increased risk for neurologic deficits. Cerebellar symptoms are not prominent and appear in adolescent or adult patients with this syndrome. We report a 2-year-old female with Crigler-Najjar syndrome type I who presented severe cerebellar symptoms revealing bilirubin encephalopathy. The patient improved slowly with the duration of phototherapy. Cerebellar symptoms can be the
Gerard A. Banez; Bruce E. Compas
Associations of children's daily stressful events and their parents' daily hassles and psychological symptoms with children's emotional\\/behavioral problems were examined in a sample of fourth- and fifth-grade children and their parents. Correlational analyses indicated that children's self-reports of depressive symptoms were associated with children's daily stressors and mothers' daily hassles, and children's selfreports of anxiety symptoms were associated with children's
Morlock, Robert; Coon, Cheryl; van Willigenburg, Arjen; Panagides, John
Objective. To assess the ability of mental health professionals to use the 4-item Negative Symptom Assessment instrument, derived from the Negative Symptom Assessment-16, to rapidly determine the severity of negative symptoms of schizophrenia. Design. Open participation. Setting. Medical education conferences. Participants. Attendees at two international psychiatry conferences. Measurements. Participants read a brief set of the 4-item Negative Symptom Assessment instructions and viewed a videotape of a patient with schizophrenia. Using the 1 to 6 4-item Negative Symptom Assessment severity rating scale, they rated four negative symptom items and the overall global negative symptoms. These ratings were compared with a consensus rating determination using frequency distributions and Chi-square tests for the proportion of participant ratings that were within one point of the expert rating. Results. More than 400 medical professionals (293 physicians, 50% with a European practice, and 55% who reported past utilization of schizophrenia ratings scales) participated. Between 82.1 and 91.1 percent of the 4-items and the global rating determinations by the participants were within one rating point of the consensus expert ratings. The differences between the percentage of participant rating scores that were within one point versus the percentage that were greater than one point different from those by the consensus experts was significant (p<0.0001). Participants rating of negative symptoms using the 4-item Negative Symptom Assessment did not generally differ among the geographic regions of practice, the professional credentialing, or their familiarity with the use of schizophrenia symptom rating instruments. Conclusion. These findings suggest that clinicians from a variety of geographic practices can, after brief training, use the 4-item Negative Symptom Assessment effectively to rapidly assess negative symptoms in patients with schizophrenia. PMID:20805916
A. C. Huizink; P. A. C. van Lier; A. A. M. Crijnen
Background\\/Aims: Symptoms of attention deficit hyperactivity disorder (ADHD) have often been associated with early-onset smoking. We hypothesize that reductions in ADHD symptoms due to an intervention have a mediating effect on early-onset smoking. Methods: In a universal, school-based, randomized controlled intervention trial, we examined whether intervention-induced reductions in ADHD symptoms at age 9 mediated the reduced risk of tobacco use
D. H. Taylor Jr; M. Kuchibhatla; T. Østbye; B. L. Plassman; E. C. Clipp
The objective of the study was to determine whether spousal caregiving and bereavement increases caregiver depressive symptoms. We followed 1,967 community-dwelling elderly couples from the 1993 Health and Retirement Study (HRS) until 2002 (five bi-annual surveys) or death. Depressive symptoms were measured by the Center for Epidemiological Studies-Depression (CESD) scale. Adjusted depressive symptoms were higher for females for three of
Linda A. Merlino; John C. Rosecrance; Dan Anton; Thomas M. Cook
Musculoskeletal disorders (MSDs) are a major cause of work-related disability and lost-time illnesses for many occupational groups. This study determined the prevalence of musculoskeletal symptoms among young construction workers. A symptom and job factors survey was self-administered to 996 construction apprentices. Prevalence was determined by the percent of positive responses to musculoskeletal symptom questions. Odds ratios and 95 percent confidence
Nancy S. Weinfield; Lisa Ingerski; Stacey Coffey Moreau
In this study we explored the relation between maternal and paternal depressive symptoms and toddler adjustment in a community\\u000a sample, testing direct, additive, and interactive models of parental depressive symptoms and child adjustment. Participants\\u000a were 49 families with 30-month-old children. Data were collected on maternal and paternal depressive symptoms and marital\\u000a quality, as well as on toddler internalizing and externalizing
Tasneem Z. Naqvi; Asim M. Rafique; Vonny Andreas; Masoud Rahban; James Mirocha; Syed S. A. Naqvi
Objective: We examined the influence of gender on the prevalence of acute coronary syndrome (ACS) and the severity of depressive symptoms post-ACS.Methods: Patients received a Zung self-assessment questionnaire at hospital discharge for unstable angina (UA) or acute myocardial infarction (AMI) and returned it by mail. Major depressive symptoms were diagnosed based on a summed depressive symptoms (SDS) score of >50.
David F. Tolin; Carol M. Woods; Jonathan S. Abramowitz
The aim of this study was to examine the relationship between symptom presentation in obsessive–compulsive disorder (OCD) and dysfunctional beliefs hypothesized to relate to OCD. Five-hundred sixty two undergraduates completed self-report measures of OCD symptoms and OCD-related beliefs, as well as measures of social anxiety and depression. The tendency to overestimate threat significantly predicted the OCD symptom domains of washing,
A Torén; K Öberg; B Lembke; K Enlund; A Rask-Andersen
Tractor driving might be one causal risk factor in the incidence of low-back and hip symptoms among farmers. Information on the annual exposure to tractor driving and its distribution among different work operations is scarce. The purpose of this study was to quantify the total and the annual time driving tractors among Swedish farmers and its distribution into different work
He, Wenkui; Beyer, Christof; Fleckenstein, Jan; Jang, Eunseon; Kalbacher, Thomas; Naumov, Dimitri; Shao, Haibing; Wang, Wenqing; Kolditz, Olaf
Worldwide, sustainable water resource management becomes an increasingly challenging task due to the growth of population and extensive applications of fertilizer in agriculture. Moreover, climate change causes further stresses to both water quantity and quality. Reactive transport modeling in the coupled soil-aquifer system is a viable approach to assess the impacts of different land use and groundwater exploitation scenarios on the water resources. However, the application of this approach is usually limited in spatial scale and to simplified geochemical systems due to the huge computational expense involved. Such computational expense is not only caused by solving the high non-linearity of the initial boundary value problems of water flow in the unsaturated zone numerically with rather fine spatial and temporal discretization for the correct mass balance and numerical stability, but also by the intensive computational task of quantifying geochemical reactions. In the present study, a flexible and efficient tool for large scale reactive transport modeling in variably saturated porous media and its applications are presented. The open source scientific software OpenGeoSys (OGS) is coupled with the IPhreeqc module of the geochemical solver PHREEQC. The new coupling approach makes full use of advantages from both codes: OGS provides a flexible choice of different numerical approaches for simulation of water flow in the vadose zone such as the pressure-based or mixed forms of Richards equation; whereas the IPhreeqc module leads to a simplification of data storage and its communication with OGS, which greatly facilitates the coupling and code updating. Moreover, a parallelization scheme with MPI (Message Passing Interface) is applied, in which the computational task of water flow and mass transport is partitioned through domain decomposition, whereas the efficient parallelization of geochemical reactions is achieved by smart allocation of computational workload over multiple compute nodes. The plausibility of the new coupling is verified by several benchmark tests. In addition, the efficiency of the new coupling approach is demonstrated by its application in a large scale scenario, in which the environmental fate of pesticides in a complex soil-aquifer system is studied.
Englund, Michelle M; Siebenbruner, Jessica
This study extends previous research investigating the developmental pathways predicting adolescent alcohol and marijuana use by examining the cascading effects of externalizing and internalizing symptoms and academic competence in the prediction of use and level of use of these substances in adolescence. Participants (N=191) were drawn from a longitudinal study of first-born children of low-income mothers. Using data from ages 7, 9, 12, and 16 years, a series of nested two-part (semi-continuous) path models from a developmental cascade modeling framework were compared. Controlling for gender, SES, mother's age at child's birth, and minority status, we found (a) within-domain rank-order stability across time, (b) significant cross-domain effects over time, (c) higher externalizing symptoms significantly predicted use of alcohol and marijuana as well as higher levels of use in adolescence, and (d) higher levels of academic competence significantly added to the prediction of use of alcohol. PMID:22465287
Sperber, Ami D; Halpern, Zamir; Shvartzman, Pesach; Friger, Michael; Freud, Tami; Neville, Anat; Fich, Alex
The prevalence of gastroesophageal reflux disease (GERD) symptoms in the general population is lower in Asian than Western countries. Data are lacking for countries in the Middle East. The aim of the study was to determine the prevalence and severity of GERD symptoms among Israeli Jews. A questionnaire including 8 specific questions for GERD symptoms was administered by telephone interview to a representative sample of the population. One thousand two hundred twenty-one of 1839 individuals were successfully contacted and 981 had valid, complete data. The mean age was 45.0 years and 55% were females. Over the previous year 34.8% of the respondents reported suffering any GERD symptom. Of these 11.6% reported retrosternal burning, 11.7% retrosternal pain, 19.0% an acid taste in the mouth, and 17.5% reflux of gastric content. In all, 6.5%, 5.2%, 10.4%, and 7.9%, respectively, suffered these symptoms at least once a week, and 2.0%, 1.8%, 2.4%, and 2.3%, respectively, defined their symptoms as frequent and severe. Male sex (P=0.01) and a functional lower gastrointestinal (GI) disorder (P<0.0001) contributed significantly to the severity of upper GI reflux-like symptoms. In conclusion, GERD symptoms are common among Israeli Jews. The symptoms are generally of mild-to-moderate severity and are significantly associated with lower functional GI disorders. PMID:17450026
Delucchi, Kevin L.; Katerberg, Hilga; Stewart, S. Evelyn; Denys, Damiaan A.J.P.; Lochner, Christine; Stack, Denise E.; den Boer, Johan A.; van Balkom, Anton J.L.M.; Jenike, Michael A.; Stein, Dan J.; Cath, Danielle C.; Mathews, Carol A.
Objective Obsessive-compulsive disorder (OCD) is phenomenologically heterogeneous, and findings of underlying structure classification based on symptom grouping have been ambiguous to date. Variable-centered approaches, primarily factor analysis, have been used to identify homogeneous groups of symptoms, but person-centered latent methods have seen little use. This study was designed to uncover sets of homogeneous groupings within 1611 individuals with OCD, based on symptoms. Method Latent class analysis (LCA) models using 61 obsessive-compulsive symptoms (OCS) collected from the Yale-Brown Obsessive-Compulsive Scale were fit. Relationships between latent class membership and treatment response, gender, symptom severity and comorbid tic disorders were tested for relationship to class membership. Results LCA models of best fit yielded three classes. Classes differed only in frequency of symptom endorsement. Classes with higher symptom endorsement were associated with earlier age of onset, being male, higher YBOCS symptom severity scores, and comorbid tic disorders. There were no differences in treatment response between classes. Conclusions These results provide support for the validity of a single underlying latent OCD construct, in addition to the distinct symptom factors identified previously via factor analyses. PMID:21145539
Brennan, Annie M; Hainsworth, Cassandra; Starling, Jean; Korgaonkar, Mayuresh S; Harris, Anthony W F; Williams, Leanne M
The diagnostic boundary between schizophrenia and bipolar disorder can be unclear, particularly with early onset. We assessed if emotion brain circuits differentiate psychosis versus mania symptoms in a series of six early onset patients. Symptoms were dissociated by direction, awareness condition, and brain regions. Greater psychosis symptoms were correlated with greater prefrontal, anterior cingulate, amygdala, and fusiform face area activation during masked fear processing. By contrast, greater mania symptoms were correlated with less amygdala activation during unmasked fear and happy processing. This suggests emotion dysfunction in schizophrenia versus bipolar disorder may arise from partially distinct neural mechanisms of susceptibility. PMID:25265277
McLeod, Michael; Torchia, Daniele; Romanelli, Paolo
Drug rash with eosinophilia and systemic symptoms syndrome is a severe idiosyncratic drug reaction with a long latency period. It has been described using many terms; however, drug rash with eosinophilia and systemic symptoms syndrome appears to be the most appropriate. This syndrome causes a diverse array of clinical symptoms, anywhere from 2 to 8 weeks after initiating the offending drug. Standardized criteria for the diagnosis have been developed; however, their utility remains to be validated. Unfortunately, the management of drug rash with eosinophilia and systemic symptoms syndrome is not well supported by strong evidence-based data. PMID:23882307
Silva, Carlos Eduardo Dilen da; Niedermeier, Bruno Taccola; Portinho, Fernando
Introduction?The indirect laryngoscopy has an important role in the characterization of reflux laryngitis. Although many findings are nonspecific, some strongly suggest that the inflammation is the cause of reflux. Objective?The aim of this study was to evaluate the correlation between reflux symptoms and the findings of indirect laryngoscopy. Methods?We evaluated 27 patients with symptoms of pharyngolaryngeal reflux disease. Results?Laryngoscopy demonstrated in all patients the presence of hypertrophy of the posterior commissure and laryngeal edema. The most frequent symptoms were the presence of dry cough and foreign body sensation. Conclusion?There was a correlation between the findings at laryngoscopy and symptoms of reflux.
215 Introduction Osteoporosis can be a devastating secondary symptom of both acute and congenital compartment. Keywords: Osteoporosis, Neuromuscular Disease, Bone, Spinal Muscular Atrophy (SMA), Spinal
L. A. Monagle; A. J. Dan; R. T. Chatterton; G. A. Hudgens
The present study objectives were three. First, the factor structure of Chesney and Tasto's Menstrual Symptom Questionnaire (MSQ) was reexamined to determine whether Chesney and Tasto's (1975a) two?factor or Webster's (1980) and Stephenson, Denney, and Aberger's (1983) multifactor result could be replicated. Second, the internal?consistency reliability of the MSQ in the present study was determined. Third, known and suspected menstrual
Blanchard, Jack J.; Kring, Ann M.; Horan, William P.; Gur, Raquel
Negative symptoms in schizophrenia are related to poor functional outcome, persistent over time, a source of burden for caregivers, and only minimally responsive to currently available medications. A major challenge to developing efficacious interventions concerns the valid and reliable assessment of negative symptoms. In a recent consensus statement on negative symptoms, a central recommendation was the need to develop new assessment approaches that address the limitations of existing instruments. In the current report, we summarize the background and rationale for the Collaboration to Advance Negative Symptom Assessment in Schizophrenia (CANSAS). The CANSAS project is an National Institute of Mental Health-funded multisite study that is constructing a next-generation negative symptom scale, the Clinical Assessment Interview for Negative Symptoms (CAINS). The CAINS is being developed within a data-driven iterative process that seeks to ensure the measure’s reliability, validity, and utility for both basic psychopathology and treatment development research. PMID:20861151
Hultcrantz, Elisabeth; Ericsson, Elisabeth; Hemlin, Claes; Hessén-Söderman, Anne-Charlotte; Roos, Kristian; Sunnergren, Ola; Stalfors, Joacim
Tonsillotomy (TT) is now used more often than tonsillectomy (TE) for tonsil obstructive symptoms in Sweden. Both TE and TT give high patient satisfaction although TT results in fewer postoperative bleedings and shorter time when analgesics are needed. The objective of this study is to analyze the current prevalence of different tonsil surgery procedures, the rates of early and late bleeding and other complications. Data from the National Tonsil Surgery Register in Sweden were analyzed. Patients 1-15 years operated for symptoms due to tonsil hypertrophy were included. Surgical procedure, technique and bleedings during hospital stay were registered. Thirty days after surgery, unplanned contacts due to bleeding, infection or pain were reported as were symptom relief after 6 months. 24,083 patients were registered. Of the 10,826 children 1-15 years operated for obstructive symptoms, 64 % were TT or TT+A, and 34 % TE, TE+A. 69 % answered the 30-day questionnaire and 50 % the 6 months. Bleeding in hospital occurred in 1.38 %, late bleedings in 2.06 %: 3.7 % after TE+A, 0.8 % after TT+A. Differences in readmissions due to bleeding, number of days using analgesics, health care contacts due to pain and nosocomial infections were significant between TT and TE, but not differences with regard to symptom relief after 6 months. PMID:23385384
Sucandy, Iswanto; Chrestiana, Dewi; Bonanni, Fernando; Antanavicius, Gintaras
Background: Gastroesophageal reflux disease (GERD) is prevalent in morbidly obese patients, and its severity appears to correlate with body mass index (BMI). Aim: The aim of this study is to investigate the status of GERD after laparoscopic sleeve gastrectomy (LSG). Materials and Methods: A prospectively maintained database of all the patients who underwent LSG from February 2008 to May 2011 was reviewed. Results: A total of 131 patients were included. The mean age and the BMI of the patients were 49.4 years and 48.9 kg/m2, respectively. Prior to LSG, subjective reflux symptoms were reported in 67 (51%) patients. Anatomical presence of hiatal hernia was endoscopically confirmed in 35 (52%) patients who reported reflux symptoms prior to LSG. All these patients underwent simultaneous hiatal hernia repair during their LSG. The overall mean operative time was 106 min (range: 48-212 min). There were no intra- and 30-day postoperative complications. Out of the 67 preoperative reflux patients, 32 (47.7%) reported resolution of their symptoms after the operation, 20 (29.9%) reported clinical improvement, and 12 (22.2%) reported unchanged or persistent symptoms. Three patients developed new-onset reflux symptoms, which were easily controlled with proton pump inhibitors. No patient required conversion to gastric bypass or duodenal switch because of the severe reflux symptoms. At 18 months, the follow-up data were available in 60% of the total patients. Conclusion: LSG results in resolution or improvement of the reflux symptoms in a large number of patients. Proper patient selection, complete preoperative evaluation to identify the presence of hiatal hernia, and good surgical techniques are the keys to achieve optimal outcomes. PMID:26110129
Lauren B. Gerson; Robert Edson; Philip W. Lavori; George Triadafilopoulos
OBJECTIVE:Accurately predicting Barrett’s esophagus (BE) in patients with gastroesophageal reflux disease (GERD) is difficult. Using logistic regression analysis of symptom questionnaire scores we created a model to predict the presence of BE.METHODS:We conducted a logistic regression analysis of symptom data collected prospectively on 517 GERD patients and created a prediction model based on patient gender, age, ethnicity, and symptom severity.RESULTS:There
Lauren B. Gerson; Robert Edson; Philip W. Lavori; George Triadafilopoulos
OBJECTIVE:Accurately predicting Barrett's esophagus (BE) in patients with gastroesophageal reflux disease (GERD) is difficult. Using logistic regression analysis of symptom questionnaire scores we created a model to predict the presence of BE.METHODS:We conducted a logistic regression analysis of symptom data collected prospectively on 517 GERD patients and created a prediction model based on patient gender, age, ethnicity, and symptom severity.RESULTS:There
Jensen, Mark P.; Kuehn, Carrie M.; Amtmann, Dagmar; Cardenas, Diane D.
Objective To determine (1) the frequency, severity, and reported course of 7 symptoms in persons with spinal cord injury (SCI) and (2) the association between these symptoms and patient functioning. Design Postal survey. Setting Community. Intervention A survey that included measures of the frequency, severity, and recalled course of pain, fatigue, numbness, weakness, shortness of breath, vision loss, and memory loss, as well as a measure of community integration and psychologic functioning was mailed to a sample of persons with SCI. One hundred forty-seven usable surveys were returned (response rate, 43% of surveys mailed). Main Outcome Measures The frequency and average severity of each symptom was computed, and the frequencies of each type of reported course were noted. Analyses estimated the associations among the symptoms, and between symptom severity and measures of patient functioning. Results The most common symptoms were pain, weakness, fatigue, and numbness. All symptoms were reported to remain the same or to get worse more often than they were reported to improve once they began. Pain, weakness, fatigue, and memory loss were the symptoms most closely associated with patient functioning. Conclusions Patients with SCI must deal with a number of secondary complications in addition to any disability caused by the injury itself. Of 7 symptoms studied, pain, weakness, and fatigue appeared to be most common and most closely linked to patient social and mental health functioning. Research is needed to identify the causal relationships between perceived symptoms and quality of life in patients with SCI and to identify effective treatments for those symptoms shown to impact patient functioning. PMID:17466734
Grosso, Justine A; Kimbrel, Nathan A; Dolan, Sara; Meyer, Eric C; Kruse, Marc I; Gulliver, Suzy B; Morissette, Sandra B
Coping style may partially account for the frequent co-occurrence of posttraumatic stress disorder (PTSD) and alcohol-use disorder (AUD). We hypothesized that avoidant and action-oriented coping styles would moderate the association between PTSD symptom severity and alcohol outcomes among U.S. Operation Enduring Freedom/Operation Iraqi Freedom veterans, such that PTSD symptoms would be most strongly and positively associated with negative alcohol-related consequences and drinking quantity when action-oriented coping was low and avoidant coping was high. The sample (N = 128; 85.2% male, M = 37.8 years old, 63.3% Caucasian) completed a diagnostic assessment for PTSD and AUD and self-report surveys measuring coping styles, drinking quantity, and negative alcohol-related consequences. Consistent with the main hypothesis, a 3-way interaction among PTSD symptom severity, avoidant coping, and action-oriented coping was found in the predicted direction (d = 0.47-0.55). Post hoc descriptive analyses indicated that veterans with a current diagnosis of PTSD, low action-oriented coping, and high avoidant coping had worse alcohol outcomes and were twice as likely to meet criteria for current AUD compared with veterans with fewer risk factors. Findings suggest that the combination of PTSD and maladaptive coping styles may be more important for understanding alcohol-related outcomes than the presence of any of these variables in isolation. PMID:25158641
Wróblewska, Paula; Adamczuk, Piotr; Kopczy?ski, Przemys?aw
Currently, food allergy is considered to be one of the diseases of civilization, which occurs as a result of the changing conditions of life and environmental changes (e.g. increased popularity of cesarean delivery, excessive hygienic regime during the neonatal-infantile period). Based on medical statistics, it can be concluded that this problem will be intensified. Consumption of food is one of the main activities in human life. What and how one eats affects our health. Meals eaten regularly provide the components necessary for the energy metabolism. Multicultural society, travel, and new trends affect the diversity of food consumed. The mechanism of food allergy reaction covers all 4 types of the immune response of the classical division of Gell and Coombs. The percentage of the immune response was assessed by Chandra as follows: type I – 48%, type II – 6%, type III – 10%, and type IV – 18%. The article presents the risk factors for food allergy, most common symptoms, preventive measures and characteristics of food products that are potential allergens. PMID:24278058
The diagnosis of a polyneuropathy (PNP) is particularly a clinically based diagnosis. The polyneuropathic syndrome consists of typical symptoms like paraesthesias, pain, cramps and fasciculations as well as characteristic signs like loss of tendon reflexes, weakness and wasting of muscles, sensory loss, cranial nerve palsy and alterations of the autonomic nervous system. The analysis of manifestation-types is very important for the differential diagnosis. The symmetrical sensory type of manifestation can be found in the beginning of almost all toxic neuropathies as well as in uremic and diabetic neuropathy. The symmetrical-motor type of manifestation can be a further development of the symmetrical sensory type of manifestation or exists from the beginning in the case for example of Guillain-Barré-Syndrome. The asymmetric type of manifestation can be observed in the vascular neuropathies and in some types of inflammatory neuropathies like the neuroborrelioses or the neuralgic amyotrophy. The investigation of the CSF, electromyography and electroneurography as well as a great number of chemical lab tests are important for the etiological classification. According to the etiology, the polyneuropathies can be subdivided into four groups such as inflammatory, vascular, exotoxic and endotoxic-metabolic-hereditary diseases. The most frequent etiologies are diabetes mellitus and chronic alcoholism. PMID:8191381
Retinal function can be documented noninvasively and objectively by electroretinography, complementing clinical examinations. Symptoms of nightblindness and of dayblindness with photoaversion, nystagmus, poor vision in infants or unclear visual field defects are meaningful indications for ERG testing. We use standardized (ISCEV) full-field single flash ERGs to evaluate the function of the rod- and of the cone-system. In infants, general anesthesia is useful to combine an abbreviated ERG protocol with ophthalmoscopy and fundus photography. ERG testing facilitates to distinguish between functional deficits in the rod- and cone-system, between congenital-stationary retinal dysfunction and progressive retinal heredo-degenerations. Frequently a functional deficit of the retina without ophthalmoscopic changes can be assessed. These entities include achromatopsia, congenital stationary night blindness, early stages of retinitis pigmentosa (RP) or progressive cone dystrophy, as well as toxic retinal changes. Congenital amaurosis Leber (LCA), infantile RP, Usher's syndrome and retinal involvement in other neuropediatric or metabolic syndromes can be diagnosed or excluded by ERG recording early-on. Synoptic evaluation of the full-field ERG, pattern-ERG and VEP completes neuro-ophthalmological screening. PMID:10420379
Kucharská, Jarmila; Ostatníková, Daniela; Babinská, Katarína; Nakládal, Dalibor; Crane, Fred L.
Background. Autism is a spectrum of neurodevelopmental disorders with manifestation within 3 years after birth. Manifestations of autism include behavior problems (hyperactivity, toys destruction, self-harm, and agression) and sleep and eating disorders. Etiology of autism is poorly understood. Oxidative stress and antioxidants can participate in pathobiochemical mechanisms of autism. Methods. Twenty-four children, aged 3–6 years, with autism according to the DSM IV criteria and using CARS were included in the study. Concentrations of CoQ10?TOTAL, ?- and ?-tocopherol, ?-carotene, and lipid peroxidation were determined in plasma before and after three months of supportive therapy with ubiquinol at a daily dose 2 × 50?mg. Data on behavior of the children were collected from parents at the same time. Results. Ubiquinol supportive therapy improved symptoms in children with autism, as communication with parents (in 12%), verbal communication (in 21%), playing games of children (in 42%), sleeping (in 34%), and food rejection (in 17%), with CoQ10?TOTAL plasma level above 2.5??mol/L. Conclusions. Beneficial effect of ubiquinol in children with autism has been demonstrated for the first time. We assume that plasma concentration of CoQ10?TOTAL and lipid peroxidation could be used as relevant biomarkers of ubiquinol supportive therapy. PMID:24707344
Grosshans, E; Jenn, P; Baumann, R; Weill, J P; Basset, A
In most cases the ano-cutaneous clinical symptoms correlated to diseases of the gastro-intestinal tract are not specific (erythema, itching, wounds or scarring). However in the following diseases occasional dermatological lesions may directly contribute to their diagnosis: in Crohn's disease, tuberculosis of bowel, chronic entamoebiasis and bilharziosis, the skin lesions of the anal area have the same histological structure as the gut lesions. Perianal fistulas and ulcers are frequent in Crohn's disease especially if there is a colonic and rectal spreading; they respond badly to steroid therapy and are often correlated with a worse prognosis. Perianal specific lesions occur often in oxyuriasis in children, in candidiasis of the digestive tract, in systemic aphthosis and in some malignancies. In other gastro-intestinal disturbances, the dermatological and features are less specific and can only be suggestive: iatrogenic and microbial diarrheas, side-effects of laxatives, proctological diseases. It has to be emphasized that pruritus ani is only induced by deeper lesions when they spread to the perianal skin. In proctological practice, contact dermatitis by sensitivity to anaesthetics or suppository balsams (Peruvian balsam), itching or burning atrophy by topical steroid abuse, non-diagnosed fungal (candidiasis), bacterial (erythrasma) or psoriatic intertrigos (flexural psoriasis) may sometimes explain the failure of therapy. PMID:485013
Cohen, Ana Luisa V.; Roh, Jung Hyeob; Nallapareddy, Sreedhar R.; Hook, Magnus; Murray, Barbara E.
Expression of adhesin to collagen of Enterococcis faecalis (ace), a known virulence factor, is increased by environmental signals such as the presence of serum, high temperature, and bile salts. Currently, the enterococcal regulator of survival (Ers) of E. faecalis strain JH2-2 is the only reported repressor of ace. Here, we show that for strain OG1RF, Ers is not involved in the regulation of ace. Our data showed similar levels of ace expression by OG1RF and its ?ers derivative in the presence of bile salts, serum, and high temperature. Using ace promoter-lacZ fusions and site-directed mutagenesis, we confirmed these results and further showed that, while the previously designated Ers box is important for increased expression from the ace promoter of OG1RF, the region responsible for the increase is bigger than the Ers box. In summary, these results indicate that, in strain OG1RF, Ers is not a repressor of ace expression. Although JH2-2 and OG1RF differ by 6 nucleotides in the region upstream of ace as well as in production of Fsr and gelatinase, the reason(s) for the difference in ace expression between JH2-2 and OG1RF and for increased ace expression in bile, serum and at 46°C remain(s) to be determined. PMID:23551253
Fauth, Elizabeth B.; Gerstorf, Denis; Ram, Nilam; Malmberg, Bo
Developmental processes are inherently time-related, with various time metrics and transition points being used to proxy how change is organized with respect to the theoretically underlying mechanisms. Using data from four Swedish studies of individuals aged 70–100+ (N = 453) who were measured every two years for up to five waves, we test whether depressive symptoms (CES-D) are primarily driven by aging-, disablement-, or mortality-related processes, as operationally defined by time-from-birth, time-to/from-disability onset (first reported impairment in Activities of Daily Living), and time-to-death metrics. Using an approach based on Akaike weights, we tested whether developmental trajectories (for each time metric) of depressive symptoms in late life are more efficiently described as a single continuous process or as a two-phase process. Comparing fits of linear and multi-phase growth models, we found that two-phase models demonstrated better fit than single-phase models across all time metrics. Time-to-death and time-to/from-disability-onset models provided more efficient descriptions of changes in depressive symptoms than did time-from-birth models, with time-to-death models representing the best overall fit. Our findings support prior research that late-life changes in depressive symptoms are driven by disablement and, particularly, mortality processes, rather than advancing chronological age. From a practical standpoint, time-to/from-disability-onset and particularly, time-to-death metrics may provide better “base” models from which to examine changes in late-life depressive symptoms and determine modifiable risk and protective factors. Developmental researchers across content areas can compare age with other relevant time metrics to determine if chronological age or other processes drive the underlying developmental change in their construct of interest. PMID:24491214
Massin, N; Hecht, G; Ambroise, D; Héry, M; Toamain, J P; Hubert, G; Dorotte, M; Bianchi, B
Objectives To measure the levels of exposure to nitrogen trichloride (NCl3) and aldehydes among cleaning and disinfecting workers in the atmosphere of food industry plants during cleaning and disinfecting operations, and to examine how they relate to irritant and chronic respiratory symptoms—which are indices of pulmonary function—and bronchial hyperresponsiveness (BHR) to methacholine. Methods 175 exposed workers (M?=?149; F?=?26) recruited from 17 enterprises of the food industry (8 cattle, pig, and ovine slaughterhouses, 8 fowl slaughterhouses, and 1 catering firm) and 70 non?exposed workers (M?=?52; F?=?18) were examined. Concentration levels of NCl3 and aldhehydes were measured by personal sampling. Symptoms were assessed by means of a questionnaire and the methacholine bronchial challenge (MBC) test using an abbreviated method. Subjects were labelled MBC+ if forced expiratory volume in one second (FEV1) fell by 20% or more. The linear dose?response slope (DRS) was calculated as the percentage fall in FEV1 at last dose divided by the total dose administered. Results 277 air samples were taken in the 17 food industry plants. For a given plant and in a given workshop, the actual concentrations of chloramines, aldehydes, and quaternary ammonium compounds were measured with personal samplers during the different steps of the procedures. For each cleaner, a total exposure index ? was calculated. A statistically significant concentration?response relationship was found between eye, nasal, and throat symptoms of irritation—but not chronic respiratory symptoms—and exposure levels or exposure duration. No relation was found between BHR and exposure. Conclusions These data show that cleaning and disinfecting workers in the food industry are at risk of developing eye, nasal, and throat irritation symptoms. Although NCl3 exposure does not seem to carry a risk of developing permanent BHR, the possibility of transient BHR cannot be ruled out entirely. PMID:16973735
Higher rates of reported morbidity among women are sometimes attributed to lower thresholds among women for experiencing and reporting symptoms. Gender differences in the perception of signs and symptoms of minor illness were examined on data from the MRC Common Cold Unit. Volunteers assessed the presence and severity of colds at the end of their stay in the Unit, using
Varela, R. Enrique; Weems, Carl F.; Berman, Steven L.; Hensley, Lauren; de Bernal, Maria Clara Rodriguez
Latin American youth in the United States tend to report more internalizing symptoms than white non-Latino youth, yet little is known about the factors that may contribute to such differences. The present study examined the role that anxiety sensitivity, gender, and ethnic minority status may play in the expression of internalizing symptoms across…
Forrest Scogin; Jodie Shackelford; Noelle Rohen; Jamie Stump; Mark Floyd; Nancy McKendree-Smith; Christine Jamison
Geriatric depression is a relatively commonly occurring mental disorder. A subpopulation of depressed older adults are those who have engaged in or completed pharmacotherapy, yet continue to experience depressive symptoms. We review the prevalence, psychosocial effects, and treatment of residual symptoms of depression in older adults. Data from previous studies conducted by our group are presented to support our contention
... signs and symptoms of ARDS are feeling like you can't get enough air into your lungs, rapid breathing, and a low blood oxygen level. Other signs and symptoms depend on the cause of ARDS. They may ... is causing ARDS, you may have a cough and fever before you ...
Anne Hudak; Matthew Warner; Carlos Marquez de la Plata; Carol Moore; Caryn Harper; Ramon Diaz-Arrastia
Traumatic brain injury (TBI) is associated with an increased risk of depressive symptoms. Recent imaging studies on spontaneous depression have implicated several brain structures; however, few studies have done the same for post-TBI depression. We report on a pilot observational study correlating atrophy of brain regions of interest in subjects after TBI with depressive symptoms measured by the Beck Depression
Weisz, John R.; Francis, Sarah E.; Bearman, Sarah Kate
Extensive research has linked youth depression symptoms to low levels of perceived control, using measures that reflect "primary control" (i.e., influencing objective conditions to make them fit one's wishes). We hypothesized that depressive symptoms are also linked to low levels of "secondary control" (i.e., influencing the psychological impact…
Akhter, Ahmed; Fiedorowicz, Jess G.; Zhang, Tao; Potash, James B.; Cavanaugh, Joseph; Solomon, David A.; Coryell, William H.
Objectives Analyses of seasonal variation of manic and depressive symptoms in bipolar disorder in retrospective studies examining admission data have yielded conflicting results. We examined seasonal variation of mood symptoms in a prospective cohort with long-term follow-up: The Collaborative Depression Study (CDS). Methods The CDS included participants from five academic centers with a prospective diagnosis of bipolar I or II disorder. The sample was limited to those who were followed for at least 10 years of annual or semi-annual assessments. Time series analyses and autoregressive integrated moving average (ARIMA) models were used assess seasonal patterns of manic and depressive symptoms. Results A total of 314 individuals were analyzed [bipolar I disorder: (n = 202) and bipolar II disorder: (n = 112)] with both disorders exhibiting the lowest depressive symptoms in summer and highest around the winter solstice, though the winter peak in symptoms was statistically significant only with bipolar I disorder. Variation of manic symptoms was more pronounced in bipolar II disorder, with a significant peak in hypomanic symptomatology in the months surrounding the fall equinox. Conclusions Significant seasonal variation exists in bipolar disorder with manic/hypomanic symptoms peaking around the fall equinox and depressive symptoms peaking in months surrounding the winter solstice in bipolar I disorder. PMID:23621686
MARIKO SAITO; HIROAKI KUMANO; KAZUHIRO YOSHIUCHI; NAOMI KOKUBO; KYOKO OHASHI; YOSHIHARU YAMAMOTO; NAOHIDE SHINOHARA; YUKIO YANAGISAWA; KOU SAKABE; MIKIO MIYATA; SATOSHI ISHIKAWA; TOMIFUSA KUBOKI
Objective: This study was conducted to confirm the definition of multiple chemical sensitivity (MCS) in actual life: that multiple symptoms are provoked in multiple organs by exposure to, and ameliorated by avoidance of, multiple chemicals at low levels. We used the Ecological Momentary Assessment to monitor everyday symptoms and the active sampling and passive sampling methods to measure environmental chemical
Brose, Annette; Schmiedek, Florian; Koval, Peter; Kuppens, Peter
The autocorrelation or inertia of negative affect reflects how much negative emotions carry over from moment to moment and has been associated with increased depressive symptoms. In this study, we posed three challenges to this association by examining: (1) whether emotional inertia is relevant for depressive symptoms when assessed on a longer timescale than usual; (2) whether inertia is uniquely related to depressive symptoms after controlling for perseverative thoughts; and (3) whether inertia is related to depressive symptoms over and above the within-person association between affect and perseverative thoughts. Participants (N = 101) provided ratings of affect and perseverative thoughts for 100 days; depressive symptoms were reported before and after the study, and again after 2.5 years. Day-to-day emotional inertia was related to depressive symptoms over and above trait and state perseverative thoughts. Moreover, inertia predicted depressive symptoms when adjusting for its association with perseverative thoughts. These findings establish the relevance of emotional inertia in depressive symptoms independent of perseverative thoughts. PMID:24820350
Aneshensel, Carol S; Botticello, Amanda L; Yamamoto-Mitani, Noriko
This study describes depressive symptoms among caregivers following bereavement and connects these trajectories to earlier features of caregiving using life course and stress process theory. Data are from a six-wave longitudinal survey (five years) of spouses and adult children caring for someone with Alzheimer's Disease. The analytic subsample (N = 291) is defined by death of the care-recipient after the baseline interview. A latent class mixture model is used to identify distinctive clusters of depressive symptoms over time. Of the four trajectories identified, three represent stable symptom levels over time, with two-thirds being repeatedly symptomatic (medium symptom levels), compared to two smaller groups of repeatedly asymptomatic (effectively absent of symptoms) and repeatedly distressed (severe symptoms). In contrast, about one in five caregivers experiences improved emotional well-being over time, the temporarily distressed, who progress from severe to moderate symptom levels. Caregivers with few symptoms before bereavement tend to maintain these states afterwards, but emotionally distressed caregivers tend to become more distressed. Role overload before bereavement substantially increases the odds of following an unfavorable trajectory afterwards, whereas self-esteem and socioemotional support play protective roles. These results demonstrate that caregivers are not uniform in their emotional responses to bereavement, but follow several distinct trajectories. These trajectories are linked to their previous experiences as caregivers, in particular exposure to stressors and access to resources. These findings suggest that intervention during caregiving may facilitate adaptation following death of a loved one. PMID:15869114
Taylor, D H; Kuchibhatla, M; Ostbye, T; Plassman, B L; Clipp, E C
The objective of the study was to determine whether spousal caregiving and bereavement increases caregiver depressive symptoms. We followed 1,967 community-dwelling elderly couples from the 1993 Health and Retirement Study (HRS) until 2002 (five bi-annual surveys) or death. Depressive symptoms were measured by the Center for Epidemiological Studies-Depression (CESD) scale. Adjusted depressive symptoms were higher for females for three of the four caregiving arrangements tested (as were unadjusted baseline levels). Depressive symptoms were lowest when neither spouse received caregiving (adjusted CESD of 2.97 for males; 3.44 for females, p<0.001). They were highest when females provided care to their husband with assistance from another caregiver, (4.01) compared to (3.37; p<0.001) when males so cared for their wife. A gender by caregiving arrangements interaction was not significant (p=0.13), showing no differential effect of caregiving on CESD by gender. Depressive symptoms peaked for bereaved spouses within three months of spousal death (4.67; p<0.001) but declined steadily to 2.75 (p<0.001) more than 15 months after death. Depressive symptoms initially increased for the community spouse after institutionalization of the care recipient, but later declined. We conclude that caregiving increases depressive symptoms in the caregiver, but does not have a differential effect by gender. Increases in depressive symptoms following bereavement are short-term. PMID:18297484
Susan Nolen-Hoeksema; Cheryl Ahrens
The authors investigated whether several life events or concerns were differentially related to depressive symptoms across 3 adult age groups (young adults, middle-aged adults, and older adults). They examined the relationships of 2 measures of depressive symptoms to work status and satisfaction, relationship status and satisfaction, loneliness, recent losses, parenting strain, and caregiving. Some differences between age groups in these
Eric M. Vernberg; Annette M. La Greca; Wendy K. Silverman; Mitchell J. Prinstein
The authors used an integrative conceptual model to examine the emergence of posttraumatic stress disorder (PTSD) symptoms in 568 elementary school-age children 3 months after Hurricane An- drew. The model included 4 primary factors: Exposure to Traumatic Events, Child Characteristics, Access to Social Support, and Children's Coping. Overall, 62% of the variance in children's self- reported PTSD symptoms was accounted
Mataix-Cols, David; Nakatani, Eriko; Micali, Nadia; Heyman, Isobel
The investigation of the structure of obsessive-compulsive disorder (OCD) symptoms observed in adults is similar to those observed in children is presented. This investigation indicates the structure of OCD symptoms is the same across the entire lifespan as compared to pediatric OCD and adulthood OCD.
... and symptoms of heart failure are: Shortness of breath or trouble breathing Fatigue (tiredness) Swelling in the ankles, feet, legs, abdomen, and veins in the neck All of these symptoms are the result of fluid ... short of breath after routine physical effort, like climbing stairs. As ...
Sulkowski, Michael L.; Mariaskin, Amy; Storch, Eric A.
Objective: This study investigated the occurrence of obsessive-compulsive spectrum disorders (OCSDs) and associated symptomology in college students. Participants: Participants included 358 undergraduate students. Results: Results suggest that clinically significant levels of OCSD symptoms are relatively common. Additionally, OCSD symptoms…
Gorde, Mrugaya W.; Helfrich, Christine A.; Finlayson, Marcia L.
This study identified the trauma symptoms and life skill needs of 84 domestic violence victims from three domestic violence programs. Women completed two self-report tools: Trauma Symptom Inventory (TSI) and Occupational Self Assessment (OSA). Staff members participated in focus groups regarding their perceptions of the womens needs. Women scored…
Brief report Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11 positive, negative and disorganized symptoms of psychosis and clinical-high-risk syndromes in 20 VCFS Schizophrenia Prodromal psychosis Clinical-high-risk psychosis 1. Introduction Mental disorders
Erritty, Philip; Wydell, Taeko N.
Aim The aim of this study was to explore the general public’s perception of schizophrenia symptoms and the need to seek-help for symptoms. The recognition (or ‘labelling’) of schizophrenia symptoms, help-seeking behaviours and public awareness of schizophrenia have been suggested as potentially important factors relating to untreated psychosis. Method Participants were asked to rate to what extent they believe vignettes describing classic symptoms (positive and negative) of schizophrenia indicate mental illness. They were also asked if the individuals depicted in the vignettes required help or treatment and asked to suggest what kind of help or treatment. Results Only three positive symptoms (i.e., Hallucinatory behaviour, Unusual thought content and Suspiciousness) of schizophrenia were reasonably well perceived (above 70%) as indicating mental illness more than the other positive or negative symptoms. Even when the participants recognised that the symptoms indicated mental illness, not everyone recommended professional help. Conclusion There may be a need to improve public awareness of schizophrenia and psychosis symptoms, particularly regarding an awareness of the importance of early intervention for psychosis. PMID:23301001
Edwards, Kevin J.; Hershberger, Paul J.; Russell, Richard K.; Markert, Ronald J.
Examined the contributions of positive social support and negative social exchange in the relationship between stress and health symptoms. College student surveys indicated that negative social exchange significantly predicted physical symptoms, while positive social support did not. The relationship between negative social interaction and…
Ge, Xiaojia; Brody, Gene H.; Conger, Rand D.; Simons, Ronald L.
The association of pubertal maturation with internalizing and externalizing symptoms was examined with a sample of 867 African-American 10-12-year-old children. Children reported their pubertal development status and timing using a self-report questionnaire, and symptoms were assessed through diagnostic interviews with the children and their…
Thomson, Maria D.; Siminoff, Laura A.; Longo, Daniel R.
Background: This study explored the characteristics of colorectal cancer (CRC) patients who accessed Internet-based health information as part of their symptom appraisal process prior to consulting a health care provider. Method: Newly diagnosed CRC patients who experienced symptoms prior to diagnosis were interviewed. Brief COPE was used to…
Simeon, Daphne; Kozin, David Stephen; Segal, Karina; Lerch, Brenna; Dujour, Roxanne; Giesbrecht, Timo
Depersonalization disorder is defined in the DSM-IV-TR using a single symptom criterion, which does not do justice to the phenomenological complexity of the disorder. In 394 affected adults, the Cambridge Depersonalization Scale yielded five factors (numbing, unreality of self, perceptual alterations, unreality of surroundings, and temporal disintegration), put forth as symptom criteria for a better diagnosis of depersonalization disorder. PMID:17959254
Dallaire, Danielle H.; Pineda, Ashley Q.; Cole, David A.; Ciesla, Jeffrey A.; Jacquez, Farrah; LaGrange, Beth; Bruce, Alanna E.
This study examined the combined and cumulative effects of supportive-positive and harsh-negative parenting behaviors on children's depressive symptoms. A diverse sample of 515 male and female elementary and middle school students (ages 7 to 11) and their parents provided reports of the children's depressive symptoms. Parents provided self-reports…
Chen, Mandy; Johnston, Charlotte; Sheeber, Lisa; Leve, Craig
This study examined whether negative parental attributions for adolescent behaviour mediate the association between parental and adolescent depressive symptoms, and whether this relationship is moderated by adolescent gender. Mothers and fathers and 124 adolescents (76 girls and 48 boys; ages 14 to 18) participated. Adolescents were primarily Caucasian, and varied in the level of depressive symptoms (with 27% of the sample meeting diagnostic criteria for a current unipolar depressive disorder). Parents and adolescents completed measures of depressive symptoms, and participated in a videotaped problem-solving discussion. After the discussion, each parent watched the videotape and, at 20 s intervals, offered attributions for their adolescent's behaviour. Adolescent gender moderated the relation between parental attributions and adolescent depressive symptoms, with stronger associations for female adolescents. For both mothers and fathers, both parental depressive symptoms and negative attributions about the adolescent's behaviour made unique contributions to the prediction of depressive symptoms in adolescent females. There also was evidence that negative attributions partially mediated the link between depressive symptoms in mothers and adolescent daughters. The results are interpreted as consistent with parenting as a partial mediator between parental and adolescent depressive symptoms, and suggest that adolescent girls may be particularly sensitive to parents' negative interpretations of their behaviour. PMID:18712594
Nick Powell; Benedict Huntley; Thomas Beech; William Knight; Hannah Knight; Christopher J Corrigan
Background: Children with allergic diseases such as asthma and atopic dermatitis experience increased gastrointestinal symptoms. Further, physiological and histological abnormalities of the gastrointestinal tract in patients with allergic diseases have been reported. It is not certain whether adult patients experience increased gastrointestinal symptoms.Methods: A retrospective, case–control study of 7235 adult (?20 years old) primary care patients was conducted. A general
Clear, Paul J.; Vincent, John P.; Harris, Gerald E.
Although researchers have begun to examine the issue of ethnic and cultural factors in childhood sexual abuse (CSA), relatively little has been done to look at possible ethnic and cultural differences in psychological symptoms related to CSA. This study investigated the relationship between ethnicity and symptom presentation among Hispanic,…
Chan, Alessandra; Poulin, Francois
This study examined (1) the relation between perceived friendship instability and depressive symptoms, (2) the directionality of this link, and (3) whether the relation between friendship instability and depressive symptoms would differ according to specific friendship status (best and secondary friendships) and contexts (school, non-school, and…
Mitch Earleywine; Sara Smucker Barnwell
Cannabis smoking can create respiratory problems. Vaporizers heat cannabis to release active cannabinoids, but remain cool enough to avoid the smoke and toxins associated with combustion. Vaporized cannabis should create fewer respiratory symptoms than smoked cannabis. We examined self-reported respiratory symptoms in participants who ranged in cigarette and cannabis use. Data from a large Internet sample revealed that the use
M H Shamssain
BACKGROUND: Exposure to wood dust can cause a variety of lung problems, including chronic airflow obstruction. METHODS: Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory ratio (FEV1\\/FVC x 100), forced expiratory flow (FEF), forced mid expiratory flow (FMF), peak expiratory flow (PEF), and respiratory symptoms (cough, phlegm, breathlessness, wheezing, and nasal symptoms) were recorded in
Cynthia W. Majerske; Jason P. Mihalik; Dianxu Ren; Michael W. Collins; Cara Camiolo Reddy; Mark R. Lovell; Amy K. Wagner
Context: Evidence suggests that athletes engaging in high- intensity activities after concussion have more difficulties with cognitive recovery. Objective: To examine the role postinjury activity level plays in postconcussive symptoms and performance on neurocogni- tive tests in a population of student-athletes. Design: Retrospective cohort study with repeated measures of neurocognitive performance and symptom reporting. Setting: University-based sports concussion clinic. Patients
Mairs, Hilary; Lovell, Karina; Campbell, Malcolm; Keeley, Philip
Negative symptoms cause functional impairment and impede recovery from psychosis, not least, because of limited developments in empirically validated treatments. This article details a pilot evaluation of a behavioral activation (BA) treatment with eight people presenting with psychosis and marked negative symptoms. The rationale for this…
Zapka, Jane G.; Oakes, J. Michael; Simons-Morton, Denise G.; Mann, N. Clay; Goldberg, Robert; Sellers, Deborah E.; Estabrook, Barbara; Gilliland, Janice; Linares, Adriana C.; Benjamin-Garner, Ruby; McGovern, Paul
Examines factors that influence the prompt seeking of care for symptoms of acute myocardial infarction (AMI). Survey of adults in 20 communities in 10 states confirmed the importance of attrition and perceived self-confidence in symptom recognition in care seeking. Concludes that the lack of a significant role of health history and clinician…
Susan Nolen-Hoeksema; Cheryl Ahrens
The authors investigated whether several life events or concerns were differentially related to depressive symptoms across 3 adult age groups (young adults, middle-aged adults, and older adults). They examined the relationships of 2 measures of depressive symptoms to work status and satisfaction, relationship status and satisfaction, loneliness, recent losses, parenting strain, and caregiving. Some differences between age groups in these
Lai, Betty S.; Auslander, Beth A.; Fitzpatrick, Stephanie L.; Podkowirow, Valentina
Background: Disasters are destructive, potentially traumatic events that affect millions of youth each year. Objective: The purpose of this paper was to review the literature on depressive symptoms among youth after disasters. Specifically, we examined the prevalence of depression, risk factors associated with depressive symptoms, and theories…
Anna Dutkiewicz; Megan Lewisa; Bertram Ostendorf; WG VII
Hyperspectral images from three sensors were compared for their ability to discriminate and map selected symptoms of salinity in a dryland agricultural area in southern Australia. The symptoms mapped are widespread in this environment: the perennial halophytic shrub samphire (Halosarcia pergranulata), a salt tolerant grass, sea barley grass (Hordeum marinum) and salt encrusted pans. Airborne HyMap and satellite Hyperion imagery
Weinfield, Nancy S.; Ingerski, Lisa; Moreau, Stacey Coffey
In this study we explored the relation between maternal and paternal depressive symptoms and toddler adjustment in a community sample, testing direct, additive, and interactive models of parental depressive symptoms and child adjustment. Participants were 49 families with 30-month-old children. Data were collected on maternal and paternal…
Ruth Condray; Lisa A. Morrow; Stuart R. Steinhauer; Michael Hodgsonc; Mary Kelley
Psychiatric symptoms have been reported for individuals who experience chronic exposure to low levels of organic solvents. However, it is not known what proportion of such individuals experience psychiatric disorder; which specific disorders may be characteristic of this population; or whether bioaccumulation of lead contributes to the relationship between solvent exposure and psychiatric symptoms. Twenty-nine male journeymen painters and 32
Helmich, Rick C G; van Laarhoven, Hanneke W M; Schoonderwaldt, Hennie C; Janssen, Mirian C H
Rhabdomyolysis and peripheral neuropathy are two distinct disease entities which are rarely encountered in combination. We present a woman with rhabdomyolysis and peripheral neuropathy 3 weeks postpartum. Her symptoms were caused by bilateral femoral artery thrombosis due to postpartum cardiomyopathy (PPCM). This demonstrates that PPCM may present with predominantly non-cardial symptoms and underscores the importance of rapidly recognizing this disorder. PMID:18581059
Steve Balsis; Jeffrey A. Cully
Objectives: Depression in later life has potential grave implications and contributes to heavy emotional, medical, and economic burdens. Therefore, it is not surprising that identifying depression and its symptoms in later life has remained a sustained concern for professionals who treat older patients. Despite this concern, the current diagnostic gold standard may not identify depression symptoms equally well in older
Nijmeijer, J. S.; Hoekstra, P. J.; Minderaa, R. B.; Buitelaar, J. K.; Altink, M. E.; Buschgens, C. J. M.; Fliers, E. A.; Rommelse, N. N. J.; Sergeant, J. A.; Hartman, C. A.
The aims of this study were to investigate whether subtle PDD symptoms in the context of ADHD are transmitted in families independent of ADHD, and whether PDD symptom familiality is influenced by gender and age. The sample consisted of 256 sibling pairs with at least one child with ADHD and 147 healthy controls, aged 5-19 years. Children who…
Ross, Colin A.
Irritable bowel syndrome is characterized by chronic gastrointestinal symptoms without a demonstrable physical cause. In a subgroup of patients, irritable bowel syndrome may be part of a cluster of psychosomatic symptoms related to childhood sexual abuse. To investigate this possibility, the Dissociative Disorders Interview Schedule (DDIS), the…
Palapattu, Anuradha G.; Kingery, Julie Newman; Ginsburg, Golda S.
The present study evaluated gender role theory as an explanation for the observed gender differences in anxiety symptoms among adolescents. Specifically, the relation between gender, gender role orientation (i.e., masculinity and femininity), self-esteem, and anxiety symptoms was examined in a community sample of 114 African Americans aged 14 to…
Deakin, Julia; Lennox, Belinda
There is a worse prognosis for psychosis and schizophrenia when onset is in childhood or adolescence. However, outcomes are improved with early detection and treatment. Psychotic symptoms can be associated with a variety of disorders including schizophrenia, schizoaffective disorder, drug-induced psychosis, personality disorder, epilepsy and autistic spectrum disorder. Positive symptoms include hallucinations and delusions. Negative symptoms include apathy, lack of drive, poverty of speech, social withdrawal and self-neglect. The DSM IV criteria for schizophrenia include two or more of the following: hallucinations, delusions, disorganised speech, grossly disorganised or catatonic behaviour and negative symptoms. Adults may raise concerns about social withdrawal, bizarre ideas, a change in behaviour or a decline in achievement. Most children and young people with psychotic symptoms will not go on to develop psychosis or schizophrenia. Direct enquiry may be needed to elicit suspected unusual beliefs or hallucinations. To distinguish unusual ideas from delusions the ideas should be tested for fixity. For example by asking: 'Are you sure? Could there be another explanation?' Mood and anxiety symptoms should be explored. The assessment should include a developmental history with particular attention to premorbid functioning. Failure to make expected progress whether personal, social or academic is significant. Better outcomes in terms of symptoms and social function are associated with a shorter duration of untreated psychosis. The detection of psychotic symptoms in primary care therefore warrants an urgent referral to secondary care mental health services for assessment and treatment. PMID:23634636
Ryzhov, Anton V.
Chiral primary operators annihilated by a quarter of the supercharges are constructed in the four dimensional Script N = 4 Super-Yang-Mills theory with gauge group SU(N). These 1/4-BPS operators share many non-renormalization properties with the previously studied 1/2-BPS operators. However, they are much more involved, which renders their construction nontrivial in the fully interacting theory. In this paper we calculate Script O(g2) two-point functions of local, polynomial, scalar composite operators within a given representation of the SU(4) R-symmetry group. By studying these two-point functions, we identify the eigenstates of the dilatation operator, which turn out to be complicated mixtures of single and multiple trace operators. Given the elaborate combinatorics of this problem, we concentrate on two special cases. First, we present explicit computations for 1/4-BPS operators with scaling dimension ? <= 7. In this case, the discussion applies to arbitrary N of the gauge group. Second, we carry out a leading plus subleading large N analysis for the particular class of operators built out of double and single trace operators only. The large N construction addresses 1/4-BPS operators of general dimension.
Eller, L.S.; Rivero-Mendez, M.; Voss, J.; Chen, W-T.; Chaiphibalsarisdi, P.; Iipinge, S.; Johnson, M.O.; Portillo, C.J.; Corless, I.B.; Sullivan, K.; Tyer-Viola, L.; Kemppainen, J.; Dawson Rose, C.; Sefcik, E.; Nokes, K.; Phillips, J.C.; Kirksey, K.; Nicholas, P.K.; Wantland, D.; Holzemer, W.L.; Webel, A.R.; Brion, J.M..
The aims of this study were to examine differences in self-schemas between persons living with HIV/AIDS with and without depressive symptoms, and the degree to which these self-schemas predict depressive symptoms in this population. Self-schemas are beliefs about oneself and include self-esteem, HIV symptom management self-efficacy, and self-compassion. Beck’s cognitive theory of depression guided the analysis of data from a sample of 1766 PLHIV from the U.S. and Puerto Rico. Sixty-five percent of the sample reported depressive symptoms. These symptoms were significantly (p ? .05), negatively correlated with age (r= ?.154), education (r= ?.106), work status (r= ?.132), income adequacy (r= ?.204, self-esteem (r= ?.617), HIV symptom self-efficacy (r=?.408) and self-kindness (r=?.284); they were significantly, positively correlated with gender (female/transgender) (r=.061), white or Hispanic race/ethnicity (r= .047) and self-judgment (r=.600). Fifty-one percent of the variance (F=177.530 (df=1524); p<.001) in depressive symptoms was predicted by the combination of age, education, work status, income adequacy, self-esteem, HIV symptom self-efficacy, and self-judgment. The strongest predictor of depressive symptoms was self-judgment. Results lend support to Beck’s theory that those with negative self-schemas are more vulnerable to depression and suggest that clinicians should evaluate PLHIV for negative self-schemas. Tailored interventions for the treatment of depressive symptoms in PLHIV should be tested and future studies should evaluate whether alterations in negative self-schemas are the mechanism of action of these interventions and establish causality in the treatment of depressive symptoms in PLHIV. PMID:24093715
Elson, David W; Paweleck, James E; Shields, David W; Dawson, Matthew J; Ferrier, Gail M
High tibial osteotomy (HTO) is successful in treating symptomatic varus arthritis of the knee. We present a case where ankle pain and instability were attributed to varus ankle malalignment. This was found to be secondary to constitutional varus of the proximal tibia but the patient's knee was asymptomatic. The decision to operate on an asymptomatic knee in the hope of improving ankle symptoms took a period of careful consideration, planning and discussion. HTO was performed without immediate complication and the patient reported an excellent outcome with marked improvement in Mazur's foot and ankle score from 18 to 85. In well selected and planned cases, HTO may be considered as an instrument of deformity correction with improvement in symptoms from joints distant to the surgical site. PMID:24022901
Anne-F r anÃ§ o i s e S c h m i d The Hypothesis of a Non-E pistem ol og y1 The Hypothesis of a Non-E pistem ol og y Anne-F r a nÃ§ o i s e S c h m i d 1 . W h a t d o es t h e h y p o t h es i s o f a no n-ep i s t em o l o g y s i g ni f y ? W h at do es t h e h y p o t h es i s o f a no n-ep i s t em o l o
Shaji, S.; Bose, Srija; Kuriakose, Shan
Background: Behavioral disturbances are integral to the dementing process and contribute adversely to the quality of life of the patients and caregivers. Information regarding the nature of symptoms in Alzheimer's disease is limited in the Indian context. Aim: To study the nature of symptoms in Alzheimer's disease using the Malayalam adaptation of Behavioral Pathology in Alzheimer's disease Rating Scale (BEHAVE-AD). Materials and Methods: Forty patients diagnosed as having Alzheimer's disease as per DSM-IV criteria were studied using the Malayalam version of BEHAVE-AD. Results: Delusions and paranoid ideations were present in 53% of the sample studied and 33% had hallucinations. Activity disturbances were seen in 65%, aggressive symptoms in 75% and diurnal rhythm disturbances in 55%. Affective disturbances and anxiety symptoms were present in 37% and 43% respectively. Conclusion: The prevalence of behavioral and psychological symptoms of dementia was found to be high. PMID:19742201
Watkins, Daphne C.; Hudson, Darrell L.; Caldwell, Cleopatra Howard; Siefert, Kristine; Jackson, James S.
Purpose This study examines the influence of discrimination and mastery on depressive symptoms for African American men at young (18–34), middle (35–54), and late (55+) adulthood. Method Analyses are based on responses from 1,271 African American men from the National Survey of American Life (NSAL). Results Discrimination was significantly related to depressive symptoms for men ages 35 to 54 and mastery was found to be protective against depressive symptoms for all men. Compared to African American men in the young and late adult groups, discrimination remained a statistically significant predictor of depressive symptoms for men in the middle group once mastery was included. Implications Findings demonstrate the distinct differences in the influence of discrimination on depressive symptoms among adult African American males and the need for future research that explores the correlates of mental health across age groups. Implications for social work research and practice with African American men are discussed. PMID:24436576
Bottlender, R; Hampel, H; Sievers, M; Möller, H J
The occurrence of depressive symptoms in schizophrenia is fairly common. In contrast to earlier assumptions, they usually have unfavorable consequences on the course of the disease. The response of depressive symptoms to therapy is well documented by empirical evidence and studies. In reality, however, the treatment of depressive symptoms in cases of schizophrenia occurs too rarely. This lack of medical treatment is partially explained by the clinicians' apprehension that antidepressive therapy could provoke a flare up of the psychosis. Nonetheless, this situation is often founded on the incorrect assessment of the depressive symptoms as negative symptoms that, in turn, are regarded by many clinicians as having limited treatability. In regards to this circumstance, a rethinking is desirable and, as a matter of principle, necessary. PMID:15968875
Didehbani, Nyaz; Munro Cullum, C.; Mansinghani, Sethesh; Conover, Heather; Hart, John
We examined the relationship between a remote history of concussions with current symptoms of depression in retired professional athletes. Thirty retired National Football League (NFL) athletes with a history of concussion and 29 age- and IQ-matched controls without a history of concussion were recruited. We found a significant correlation between the number of lifetime concussions and depressive symptom severity using the Beck Depression Inventory II. Upon investigating a three-factor model of depressive symptoms (affective, cognitive, and somatic; Buckley et al., 2001) from the BDI-II, the cognitive factor was the only factor that was significantly related to concussions. In general, NFL players endorsed more symptoms of depression on all three Buckley factors compared with matched controls. Findings suggest that the number of self-reported concussions may be related to later depressive symptomology (particularly cognitive symptoms of depression). PMID:23644673
Objective. To identify socioeconomic situation factors and behavioral factors associated with the prevalence of acute symptoms among 150 printing workers in 16 printing factories in Southern Thailand. Materials and Methods. A cross-sectional study was conducted by interviewing 150 printing workers in 16 printing factories in Southern Thailand. Results. Acute symptoms comprised dizziness, drowsiness, eye irritation, light-headedness, rhinitis, shortness of breath, cough, chest tightness, nausea/vomiting, exacerbation of asthma, allergic skin reaction, and visual disorder. The prevalence of symptoms was consistently higher among workers in the printing process than among other workers. Smoking cigarettes and drinking alcohol were not associated with an increased prevalence of acute symptoms among these printing-factory workers. Conclusion. The significant associations were found between personal protective equipment and personal hygiene and prevalence of acute symptoms in printing workers. PMID:25386365
Nishikawa, Daiji; Matsunaga, Miki; Furutani, Kaichiro
This study investigated the effects of rumination (reflective pondering and brooding) on automatic thoughts (both negative and positive) and depressive symptoms. University students (N=183; 96 men) completed the Self-Rating Depression Scale (SDS), Automatic Thoughts Questionnaire-Revised (ATQ-R), and Response Style Scale (RSS). We conducted a path analysis which included gender as a factor. The results revealed that brooding was associated with negative automatic thoughts. Negative automatic thoughts contributed to the aggravation of depressive symptoms. In contrast, reflective pondering was associated with positive automatic thoughts. Positive automatic thoughts contributed to the reduction of depressive symptoms. These results indicate that rumination does not affect depressive symptoms directly. We suggest that rumination affects depressive symptoms indirectly through automatic thoughts, and that there are gender differences in the influence process. PMID:24505971
Tack, J; Stanghellini, V; Dubois, D; Joseph, A; Vandeplassche, L; Kerstens, R
Background Prucalopride is a 5-HT4 receptor agonist with gastrointestinal prokinetic activities. This integrated analysis of data from three 12-week, double-blind trials evaluated the effect of prucalopride 2 mg q.d. on common constipation symptoms in women in whom laxatives had failed to provide adequate relief. The effect of prucalopride on bowel function was outside the scope of the analysis and has been described elsewhere. Methods Women with self-reported inadequate relief from laxatives and included in the prucalopride 2 mg or placebo arm of the trials were selected for analysis. Symptom severity was determined with the Patient Assessment of Constipation Symptoms (PAC–SYM) questionnaire. Observed changes from baseline in individual item scores were also evaluated by calculating Cohen's D effect sizes using baseline standard deviation (SD) (>0.2–0.5, >0.5–0.8 and >0.8 for small, moderate and large effects, respectively). Key Results Data were analyzed for 936 women. The proportion of women with a PAC-SYM severity score >2 at baseline was 50.0% for abdominal symptoms, 71.4% for stool symptoms, and 15.5% for rectal symptoms. Excluding the women without presence of a symptom at baseline from the effect size calculations showed that prucalopride 2 mg had a large effect (>0.8) on all PAC-SYM items, including abdominal pain, abdominal discomfort, bloating, straining, and painful bowel movements. For abdominal symptoms and stool symptoms, effect sizes with prucalopride 2 mg were 1.3–2.3 times larger than those with placebo. Conclusions & Inferences Prucalopride 2 mg q.d. for 12 weeks alleviates common constipation symptoms in women in whom laxatives had failed to provide adequate relief. PMID:24106924
Watson, Nathaniel F.; Harden, Kathryn Paige; Buchwald, Dedra; Vitiello, Michael V.; Pack, Allan I.; Strachan, Eric; Goldberg, Jack
Objective: We used quantitative genetic models to assess whether sleep duration modifies genetic and environmental influences on depressive symptoms. Method: Participants were 1,788 adult twins from 894 same-sex twin pairs (192 male and 412 female monozygotic [MZ] pairs, and 81 male and 209 female dizygotic [DZ] pairs] from the University of Washington Twin Registry. Participants self-reported habitual sleep duration and depressive symptoms. Data were analyzed using quantitative genetic interaction models, which allowed the magnitude of additive genetic, shared environmental, and non-shared environmental influences on depressive symptoms to vary with sleep duration. Results: Within MZ twin pairs, the twin who reported longer sleep duration reported fewer depressive symptoms (ec = -0.17, SE = 0.06, P < 0.05). There was a significant gene × sleep duration interaction effect on depressive symptoms (a'c = 0.23, SE = 0.08, P < 0.05), with the interaction occurring on genetic influences that are common to both sleep duration and depressive symptoms. Among individuals with sleep duration within the normal range (7-8.9 h/night), the total heritability (h2) of depressive symptoms was approximately 27%. However, among individuals with sleep duration within the low (< 7 h/night) or high (? 9 h/night) range, increased genetic influence on depressive symptoms was observed, particularly at sleep duration extremes (5 h/night: h2 = 53%; 10 h/night: h2 = 49%). Conclusion: Genetic contributions to depressive symptoms increase at both short and long sleep durations. Citation: Watson NF; Harden KP; Buchwald D; Vitiello MV; Pack AI; Stachan E; Goldberg J. Sleep duration and depressive symptoms: a gene-environment interaction. SLEEP 2014;37(2):351-358. PMID:24497663
Background Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its glycerol backbone. Natural cPA and its chemically stabilized cPA derivative, 2-carba-cPA (2ccPA), inhibit chronic and acute inflammation, and 2ccPA attenuates neuropathic pain. Osteoarthritis (OA) is a degenerative disease frequently associated with symptoms such as inflammation and joint pain. Because 2ccPA has obvious antinociceptive activity, we hypothesized that 2ccPA might relieve the pain caused by OA. We aimed to characterize the effects of 2ccPA on the pathogenesis of OA induced by total meniscectomy in the rabbit knee joint. Results Intra-articular injection of 2ccPA (twice a week for 42 days) significantly reduced pain and articular swelling. Histopathology showed that 2ccPA suppressed cartilage degeneration in OA. We also examined the effects of 2ccPA on the inflammatory and catabolic responses of human OA synoviocytes and chondrosarcoma SW1353 cells in vitro. 2ccPA stimulated synthesis of hyaluronic acid and suppressed production of the metalloproteinases MMP-1, -3, and -13. However, it had no effect on the production of interleukin (IL)-6, an inflammatory cytokine. The suppressive effect of 2ccPA on MMP-1 and -3 production in synoviocytes and on MMP-13 production in SW1353 cells was not mediated by the lysophosphatidic acid receptor, LPA1 receptor (LPA1R). Conclusions Our results suggest that 2ccPA significantly reduces the pain response to OA by inducing hyaluronic acid production and suppressing MMP-1, -3, and -13 production in synoviocytes and chondrocytes. PMID:25123228
Monahan, Patrick O; Boustani, Malaz A; Alder, Catherine; Galvin, James E; Perkins, Anthony J; Healey, Patrick; Chehresa, Azita; Shepard, Polly; Bubp, Corby; Frame, Amie; Callahan, Chris
Background Dementia care providers need a clinical assessment tool similar to the blood pressure cuff (sphygmomanometer) used by clinicians and patients for managing hypertension. A “blood pressure cuff ” for dementia would be an inexpensive, simple, user-friendly, easily standardized, sensitive to change, and widely available multidomain instrument for providers and informal caregivers to measure severity of dementia symptoms. The purpose of this study was to assess the reliability and validity of the Healthy Aging Brain Care Monitor (HABC-Monitor) for measuring and monitoring the severity of dementia symptoms through caregiver reports. Methods The first prototype of the HABC-Monitor was developed in collaboration with the Indianapolis Discovery Network for Dementia, which includes 200 members representing 20 disciplines from 20 local organizations, and an expert panel of 22 experts in dementia care and research. The HABC-Monitor has three patient symptom domains (cognitive, functional, behavioral/psychological) and a caregiver quality of life domain. Patients (n = 171) and their informal caregivers (n = 171) were consecutively approached and consented during, or by phone shortly following, a patient’s routine visit to their memory care provider. Results The HABC-Monitor demonstrated good internal consistency (0.73–0.92); construct validity indicated by correlations with the caregiver-reported Neuropsychiatric Inventory (NPI) total score and NPI caregiver distress score; sensitivity to three-month change compared with NPI “reliable change” groups; and known-groups validity, indicated by significant separation of Mini-Mental Status Examination severity groups and clinical diagnostic groups. Although not designed as a screening study, there was evidence for good operating characteristics, according to area under the receiver-operator curve with respect to gold standard clinical diagnoses, relative to Mini-Mental Status Examination or NPI. Conclusion The HABC-Monitor demonstrates good reliability and validity as a clinically practical multidimensional tool for monitoring symptoms of dementia through the informal caregiver. PMID:22791987
Lars-Gunnar Lundh; Margit Wångby
The relation between causal thinking about somatic symptoms (psychological, somatic, and external symptom attribution) and the experience of somatic complaints and negative affect was studied in a community sample of 208 individuals. Although cluster analysis identified groups of individuals with psychological, somatic, and external attribution styles, the analysis also revealed groups of individuals with combinations of high or low scores
Martinez, William; Polo, Antonio J; Zelic, Kate J
Trauma exposure in youth is widespread, yet symptom expression varies. The present study employs a within-scale meta-analytic framework to explore determinants of differential responses to trauma exposure. The meta-analysis included 74 studies employing samples of youth exposed to traumatic events and who completed the Trauma Symptom Checklist for Children (TSCC). Mean weighted T scores across all TSCC subscales for U.S. samples ranged between 49 and 52. Youth outside the U.S. reported higher posttraumatic stress, anxiety, and depressive symptoms, whereas those exposed to sexual abuse reported the highest posttraumatic stress, anxiety, depressive, and dissociative symptoms. Higher female representation in samples was associated with higher symptoms on all TSCC subscales except anger. In contrast, ethnic minority representation was associated with lower depressive symptoms. Moderator analyses revealed that sexual abuse, increased percentage of females, and older age were all associated with higher posttraumatic symptoms. The present meta-analytic results help elucidate some of the divergent findings on symptom expression in youth exposed to traumatic events. PMID:25522729
Silberg, Judy L.; Bulik, Cynthia M.
Objective: We investigated the role of genetic and environmental factors in the developmental association among symptoms of eating disorders, depression, and anxiety syndromes in 8-13-year-old and 14-17-year-old twin girls. Methods: Multivariate genetic models were fitted to child-reported longitudinal symptom data gathered from clinical interview…
Selby, Debbie; Chakraborty, Anita; Myers, Jeff; Saskin, Refik; Mazzotta, Paolo; Gill, Ashlinder
The terms symptom burden and symptom distress are frequently seen in palliative care literature yet are used in multiple ways ranging from addition of symptom scores to more in-depth assessments of interference in function. Patient input to date has had little role in these varied definitions yet previous reviews have suggested the importance of such input. This mixed qualitative and quantitative prospective study was conducted to seek patient input into the definition of 'symptom burden' and to correlate burden self-ranked scores with symptom scores on the Edmonton Symptom Assessment Scale (ESAS). Results suggest that patients with advanced disease followed by palliative care providers are a group with a high level of self-defined burden. Further, any patient rating one or more symptoms on the ESAS ?7 is at high risk of self-defined burden and likely to be experiencing significant impact on physical, emotional and social functioning. Further work should look at which aspects of symptom management best promote a lessening of perceived burden. PMID:22145893
Wetter, Emily K.; El-Sheikh, Mona
Background: We assessed trajectories of children's internalizing symptoms as predicted by interactions among maternal internalizing symptoms, respiratory sinus arrhythmia (RSA) and child sex. Method: An ethnically and socioeconomically diverse sample of children (n = 251) participated during three study waves. Children's mean ages were 8.23 years…
MEnTorskAb frEMMEr fAgLIg og pErsonLIg uDvIkLIng bEnTE schnEIDEr > Susanne Jespersen er QA manager's alumner. Stausholm Nielsen, som nu er hendes mentor. "Som mindre erfaren inden for strategisk ledelse kanTAushoLM nIELsEn · 1985 Civilingeniør, elektro · Medlem af DTU Alumni · 1985 Systemprogrammør, Søren T
Bin Muhammad, Rashid
Rashid Bin Muhammad at Kent State University presents his page of lectures notes and other instructional materials on operating systems. The site is divided into a number of topics about operating systems: history, structure, process, threads, Solaris-2, CPU / process scheduling, schedule algorithm, interprocess communication, deadlock, important UNIX commands, and references. The site is then followed by links to outside resources to help supplement the material presented here. This is a great resource for computer science instructors teaching students about operating systems.
Wimberger, P.; Grübling, N.; Riehn, A.; Furch, M.; Klengel, J.; Goeckenjan, M.
Introduction: Endometriosis is a chronic disease with differing clinical presentations. Treatment strategies depend mainly on clinical presentation and patient lifestyle. In women newly diagnosed with endometriosis, it is often difficult to understand the pathophysiologic origin, the potential individual impairment due to disease and the different treatment options. Compliance with the selected treatment is therefore often not optimal. Material and Methods: In a descriptive study, data of 51 women with endometriosis (mean age 36.2?years ±?11.3) were analyzed according to the predominant clinical presentation: asymptomatic disease, disease with typical symptoms, ovarian cysts or infertility. Results: More than 50?% of patients ascribed a therapeutic benefit to surgical intervention or endocrine treatment, especially women in the subgroup with dysmenorrhea who received combined treatment. It should be noted that in the group of women facing infertility, more than half stated that they could not decide on the value of diagnostic and therapeutic reproductive medicine. Nevertheless, more than half of the women in this group became pregnant within two years after the initial diagnosis. Discussion: When deciding on the best treatment strategy for endometriosis, it is important to take account of potential pain and infertility. Women?s perception of endometriosis will vary depending on their symptoms, the time of diagnosis and their lifestyle. Offering continuous information on clinical aspects and manifestations of the disease may improve treatment outcomes. Personalized counseling is an essential part of the clinical management of the disease. PMID:25364034
Desai, Geetha; Chaturvedi, Santhosh K.; Dahale, Ajit; Marimuthu, Palaniappan
Background: Scale for assessment of somatic symptoms (SASS) has been widely used for assessing somatic complaints since many years. With impending changes in the classificatory system on somatoform disorders, we re- assessed the test-retest reliability and inter-rater reliability of SASS. Materials and Methods: SASS was administered twice with a gap of 24 h on 20 subjects for test retest reliability. Two clinicians assessed inter-rater reliability on 20 subjects. Kendall tau B and Cronbach's alpha were calculated from the data. Results: All of the items except burning sensation, weakness of mind and trembling had strong correlation with values >±0.40 on both test retest and inter-rater reliability; burning sensation and trembling were not reported by any subject. On inter-rater reliability the items constipation, diarrhea, lack of libido weren’t scored by any subjects. Cronbach's alpha for test retest was 0.982 and 0.840 indicating good internal consistency. Conclusion: Majority of the symptoms in SASS had high correlation in both test retest reliability as well as inter-rater reliability, however few items needs revision. PMID:25722506
Chronic obstructive pulmonary disease (COPD) symptoms in the morning, including dyspnea and sputum production, affect patients’ quality of life and limit their ability to carry out even simple morning activities. It is now emerging that these symptoms are associated with increased risk of exacerbations and work absenteeism, suggesting that they have a more profound impact on patients than previously thought. The development of validated patient-reported outcome (PRO) questionnaires to capture patients’ experience of COPD symptoms in the morning is, therefore, vital for establishing effective and comprehensive management strategies. Although it is well established that long-acting bronchodilators are effective in improving COPD symptoms, the limited available data on their impact on morning symptoms and activities have been obtained with non-validated PRO questionnaires. In this review, we discuss the impact of COPD symptoms in the morning and available tools used to evaluate them, and highlight specific gaps that need to be addressed to develop standardized instruments able to meet regulatory requirement. We also present available evidence on the effect of pharmacological therapies on morning symptoms. PMID:24143997
Wei, Chiaying; Kendall, Philip C.
The current study examined the relationship between child-reported parenting behaviors and children’s anxiety, depressive, and externalizing symptoms. Youth ages 7 – 14 (N = 175; 52.6% male) and their parents seeking treatment for child anxiety were evaluated. The parenting behaviors that were measured separately included father’s and mother’s acceptance, psychological control, and firm/behavioral control. Children’s symptoms were assessed using diagnostic interviews, self-reports, parent-reports, and teacher-reports. Independent t-tests revealed that children diagnosed with a primary anxiety disorder perceived higher parental control than children without an anxiety disorder. Results from regression analyses indicated that child-reported maternal acceptance was associated with lower symptoms of child anxiety, depression, and externalizing behavior, whereas psychological control predicted higher symptoms. Further, child-reported depressive symptoms moderated the relationship between maternal psychological control and children’s anxiety, such that the relationship was weaker for anxious children with more depressive symptoms. The current findings support that children’s perception of parenting behavior is associated with anxiety, and children’s depressive symptoms moderate this relationship. PMID:25061257
Ridner, S H; Deng, J; Fu, M R; Radina, E; Thiadens, S R J; Weiss, J; Dietrich, M S; Cormier, J N; Tuppo, C M; Armer, J M
Currently, there is a lack of data related to differences in symptoms and infection across different types and anatomical sites of lymphedema. The objective of this study was to examine differences in symptoms and infection status among individuals with lymphedema of the upper or lower extremities. The National Lymphedema Network initiated an online survey of self-report lymphedema data from March 2006 through January 2010. Descriptive statistics, Mann-Whitney tests, and Chi-square tests were used to analyze data. 723 individuals with upper extremity lymphedema and 1114 individuals with lower extremity lymphedema completed the survey. Individuals with extremity lymphedema experienced high symptom burden and infectious complications. Compared with individuals with upper extremity lymphedema, individuals with lower extremity lymphedema experienced more frequent and more severe symptoms (p<.001), infection episodes (p<.001), and infection-related hospitalizations (p<.001). No statistically significant differences of symptom burden and infection status were identified between individuals with lower extremity primary and secondary lymphedema. Individuals with extremity lymphedema experience substantial symptom burden and infectious complications; however, those with lower extremity lymphedema have more severe symptoms and more infections than those with upper extremity lymphedema. PMID:23342931
The purpose of this study was to characterize the symptoms and injuries experienced by NASA astronauts during extravehicular activity (space walk) spacesuit training at the Neutral Buoyancy Laboratory at Ellington Field, Houston, Texas. We identified the frequency and incidence rates of symptoms by each general body location and characterized mechanisms of injury and effective countermeasures. Based on these findings a comprehensive list of recommendations was made to improve training, test preparation, and current spacesuit components, and to design the next -generation spacesuit. At completion of each test event a comprehensive questionnaire was produced that documented suit symptom comments, identified mechanisms of injury, and recommended countermeasures. As we completed our study we found that most extravehicular mobility unit suit symptoms were mild, self-limited, and controlled by available countermeasures. Some symptoms represented the potential for significant injury with short- and long-term consequences regarding astronaut health and interference with mission objectives. The location of symptoms and injuries that were most clinically significant was in the hands, shoulders, and feet. Correction of suit symptoms issues will require a multidisciplinary approach to improve prevention, early medical intervention, astronaut training, test planning, and suit engineering.
Rhee, Hyekyun; Belyea, Michael J.; Halterman, Jill S.
Introduction Pediatric asthma is accountable for a substantial use of health care services. The purpose of this study was to systemically examine the extent to which inaccurate perception of asthma symptoms is associated with the use of health care services. Methods This exploratory study included 126 adolescents with asthma, aged between 13–20 years. Subjects were classified as having inaccurate symptom perception (IG), well controlled, accurate symptom perception (WCA), and poorly-controlled accurate symptom perception (PCA). These groups were compared with respect to health care utilization including emergency department (ED) visits, hospitalization and office visits and school absenteeism in the past 3 months. Results More adolescents in the inaccurate group had at least one hospitalization compared to adolescents in the PCA or WCA groups (23.1% vs. 11.1% vs. 2.6% respectively). A similar trend was seen for emergency department visits. Compared to WCA group, adolescents in the inaccurate group were nearly 9 times more likely to have been hospitalized, 3.4 times more likely to have visited an emergency department (ED), and 4 times more likely to have missed school days. Discussion Adolescents with inaccurate symptom perception are more likely to have hospitalizations, ED visits, and missed days from school as compared to those with accurate perceptions. The findings underscore the importance of screening for perceptual accuracy of asthma symptoms and call for interventions promoting accurate symptom assessment in adolescents with asthma to assure appropriate care. PMID:21320682
Background Previous DSM-versions recognized an inhibited and a disinhibited subtype of the Reactive Attachment Disorder (RAD). The current DSM-5 distinguishes two different disorders, instead of two subtypes of RAD. This study examined whether a split-up of the subtypes is valid. Method In 126 foster children, attachment disorder symptoms were assessed with the Disturbances of Attachment Interview. Forms of pathogenic care were identified based on dossier analyses. Associations between symptoms of attachment disorder with internalizing and externalizing problems (Child Behavior Checklist and Teacher Report Form) were examined. Results Omnibus tests showed no significant association between type of symptoms and type of pathogenic care. Exploratory analyses did reveal an univariate association between disinhibited symptoms and history of physical abuse. Disinhibited symptoms were associated with more internalizing and externalizing problems (d’s?0.50). Conclusion The distinction of inhibited and disinhibited subtypes of RAD seems valid regarding their emotional and behavioral correlations. Whereas inhibited symptoms lack a correlation, disinhibited symptoms seem to have an externalizing and internalizing correlation. Trial registration NTR1747 PMID:25057289
Ataollahi, Maryam; Akbari, Sedigheh Amir Ali; Mojab, Faraz; Alavi Majd, Hamid
Pre-menstrual syndrome is one of the most common disorders in women and impairs work and social relationships. Several treatment modalities have been proposed including herbal medicines. Considering the properties of wheat germ, this study aimed to determine the effects of wheat germ extract on the symptoms of premenstrual syndrome. This triple blind clinical trial was conducted on 84 women working in hospitals affiliated to Hamadan University of Medical Sciences. Subjects completed daily symptom record form for two consecutive months. After definitive diagnosis of premenstrual syndrome, they were randomly divided into two groups of 50 people. Then, for two consecutive months, 400 mg capsules of wheat germ extract or placebo were used three times a day, from day 16 until day 5 of the next menstrual cycle. Wheat germ significantly reduced physical symptoms (63.56%), psychological symptoms (66.30%), and the general score (64.99%). Although the severity of symptoms decreased in both groups, this reduction was more significant in the wheat germ extract group (p < 0.001). On the other hand, physical symptoms decreased only in the wheat germ extract (p < 0.001) and there was no statistically significant difference in the placebo group. No complications were observed in any of the groups. It seems that using wheat germ extract reduces general, psychological and physical symptoms. PMID:25561922
Bie?, Agnieszka; Rzo?ca, Ewa; Iwanowicz-Palus, Gra?yna; Pa?czyk-Szeptuch, Ma?gorzata
In the present study, we performed an analysis of the influence of climacteric symptoms on women's lives and activities, i.e. their quality of life (QoL). The study was performed between October 2011 and February 2012. It included 148 women aged 44-62. The study used a diagnostic survey with questionnaires. The research instrument was the Blatt-Kupperman index. The respondents were asked to complete a questionnaire on socio-demographic data, quality of life, and the influence of climacteric symptoms on life and its various aspects. The respondents experiencing moderate or severe climacteric symptoms also had stronger feelings of failure (p = 0.005), feeling that opportunities are still available (p = 0.002), of losing their youth and beauty (p < 0.0001), compared to those who had slight or no symptoms. The intensity of climacteric symptoms significantly affects women's lives and activities, i.e., their QoL. The reported intensity of climacteric symptoms is influenced by the respondents' education, residence, marital status and professional activity. The more severe the climacteric symptoms, the lower the women's quality of life, as evidenced for example by the feeling of failure and of losing one's youth, beauty and opportunities. PMID:25854298
Noterdaeme, Michele; Hutzelmeyer-Nickels, Anna
Pervasive developmental disorders are characterised by the presence of abnormalities in social interaction and communication as well as repetitive patterns of behaviours. Although early symptoms of the disorder often appear during the first two years of life, its diagnosis is often delayed. The purpose of this study is to analyse the delay between age at first symptoms and age at diagnosis as well as the characteristics of the first symptoms for the different subcategories of pervasive developmental disorders. The sample consists of 601 children with a diagnosis of a pervasive developmental disorder. Age at first symptoms, age at diagnosis and the type of the first problems are registered. The results show that children with autism show first symptoms at a mean age of 15 months whereas diagnosis is made at a mean age of 76 months. Children with Asperger's syndrome show first symptoms at a mean age of 26 months, while diagnosis is made at the mean age of 110 months. There is still a large delay between the age at which parents first report first symptoms and age at diagnosis. To improve early detection, systematic screening and training of primary care paediatricians should be implemented. PMID:20923894
van Mil, Nina H; Steegers-Theunissen, Régine P M; Bouwland-Both, Marieke I; Verbiest, Michael M P J; Rijlaarsdam, Jolien; Hofman, Albert; Steegers, Eric A P; Heijmans, Bastiaan T; Jaddoe, Vincent W V; Verhulst, Frank C; Stolk, Lisette; Eilers, Paul H C; Uitterlinden, André G; Tiemeier, Henning
Attention deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric disorder. In addition, early life environmental factors contribute to the occurrence of ADHD. Recently, DNA methylation has emerged as a mechanism potentially mediating genetic and environmental effects. Here, we investigated whether newborn DNA methylation patterns of selected candidate genes involved in psychiatric disorders or fetal growth are associated with ADHD symptoms in childhood. Participants were 426 children from a large population based cohort of Dutch national origin. Behavioral data were obtained at age 6 years with the Child Behavior Checklist. For the current study, 11 regions at 7 different genes were selected. DNA methylation levels of cord blood DNA were measured for the 11 regions combined and for each region separately. We examined the association between DNA methylation levels at different regions and ADHD symptoms with linear mixed models. DNA methylation levels were negatively associated with ADHD symptom score in the overall analysis of all 11 regions. This association was largely explained by associations of DRD4 and 5-HTT regions. Other candidate genes showed no association between DNA methylation levels and ADHD symptom score. Associations between DNA methylation levels and ADHD symptom score were attenuated by co-occurring Oppositional defiant disorder and total symptoms. Lower DNA methylation levels of the 7 genes assessed at birth, were associated with more ADHD symptoms of the child at 6 years of age. Further studies are needed to confirm our results and to investigate the possible underlying mechanism. PMID:24290898
Wehr, T A; Giesen, H A; Schulz, P M; Anderson, J L; Joseph-Vanderpool, J R; Kelly, K; Kasper, S; Rosenthal, N E
Epidemiological studies and studies of clinical populations suggest that there are primarily two opposite patterns of seasonally recurring depressions: summer depression and winter depression. In addition, there is preliminary evidence that the two seasonal types of depression may have opposite types of vegetative symptoms. In the present study, we prospectively monitored symptoms of depression in 30 patients with recurrent summer depression and 30 sex-matched patients with recurrent winter depression and compared the symptom profiles of the two groups. Consistent with predictions based on the earlier reports, we found that winter depressives were more likely to have atypical vegetative symptoms, with increased appetite, carbohydrate craving, weight gain and hypersomnia, and that summer depressives were more likely to have endogenous vegetative symptoms, with decreased appetite and insomnia. A cluster analysis performed on the patients' symptom profiles without reference to season of occurrence of their episodes separated 78% of the summer depressives and winter depressives from each other on the basis of their symptoms (chi 2 = 19.29, P less than 0.001). PMID:1791262
Neugebauer, R; Kline, J; O'Connor, P; Shrout, P; Johnson, J; Skodol, A; Wicks, J; Susser, M
OBJECTIVES. We tested whether and under what conditions miscarriage increases depressive symptoms in the early weeks following loss. METHODS. We interviewed 232 women within 4 weeks of miscarriage and 283 pregnant women and 318 community women who had not recently been pregnant. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) Scale. RESULTS. Among women who had miscarried, the proportion who were highly symptomatic on the CES-D was 3.4 times that of pregnant women and 4.3 times that of community women. Among childless women, the proportion of women who had miscarried who were highly symptomatic was 5.7 times that of pregnant women and 11.0 times that of community women. Women who had miscarried were equally depressed regardless of length of gestation; among pregnant women, depressive symptoms declined with length of gestation. Among women who had miscarried, symptom levels did not vary with attitude toward the pregnancy; among pregnant women, depressive symptoms were elevated in those with unwanted pregnancies. Prior reproductive loss and advanced maternal age (35+ years) were not associated with symptom levels in any cohort. CONCLUSIONS. Depressive symptoms are markedly increased in the early weeks following miscarriage. This effect is substantially modified by number of living children, length of gestation at loss, and attitude toward pregnancy. PMID:1415855
Wilson, Robert S.; Nag, Sukriti; Boyle, Patricia A.; Hizel, Loren P.; Yu, Lei; Buchman, Aron S.; Shah, Raj C.; Schneider, Julia A.; Arnold, Steven E.; Bennett, David A.
Context The neurobiologic basis of late life depressive symptoms is not well understood. Objective To test the hypothesis that neurodegeneration and neuronal density in brainstem aminergic nuclei are related to late life depressive symptoms. Design Longitudinal clinical-pathologic cohort study. Setting Residences of participants in the Chicago metropolitan area. Participants A total of 124 older persons without dementia in the Rush Memory and Aging Project who had annual evaluations for a mean of 5.7 years (SD = 2.8), died, and underwent a neuropathologic examination that provided estimates of the densities of Lewy bodies, neurofibrillary tangles, and aminergic neurons in the locus coeruleus, dorsal raphe nucleus, substantia nigra, and ventral tegmental area. Main Outcome Measure Number of depressive symptoms on the Center for Epidemiological Studies Depression scale averaged across annual evaluations (mean = 1.61, SD = 1.48, range: 0–6, skewness = 0.94). Results Brainstem Lewy bodies were associated with depressive symptoms and the association was attenuated in those on antidepressant medication. Brainstem tangles were associated with more depressive symptoms in those without cognitive impairment but fewer symptoms in those with mild cognitive impairment. Lower density of tyrosine-hydroxylase-immunoreactive neurons in the ventral tegmental area was robustly associated with higher level of depressive symptoms (estimate = ?0.014, SE = 0.003, p<0.001, increase in adjusted R2 = 16.3%). The association was not modified by medications or cognitive impairment. Neither tyrosine-hydroxlyase-immunoreactive neurons in the locus coeruleus nor tryptophan-hydroxlyase-immunoreactive neurons in the dorsal raphe nucleus were related to depressive symptoms. Conclusions The results suggest that the mesolimbic dopamine system, especially the ventral tegemental area, plays an important role in late life depressive symptoms. PMID:24132763
Ertmann, Ruth K.; Siersma, Volkert; Reventlow, Susanne; Söderström, Margareta
Objectives Some parents with a sick infant contact a doctor, while others do not. The reasons underlying such parental decisions have not been thoroughly studied. The purpose of this study was to explore how the actual symptoms in the infant were associated with parent-rated illness, illness severity, and the probability of the parents contacting a doctor. Design A retrospective questionnaire and a prospective diary study covering 14 months of the participating infants’ lives. Setting and subjects The 194 participating infants were followed for three months prospectively from the age of 11 to 14 months using diary cards, and retrospectively from birth until the age of 11 months by a questionnaire. Results During the three months of the diary card prospective follow-up, the infants had symptoms on average every second day, and the vast majority (92%) had 10 or more days with at least one symptom; 38% of the infants were reported to have had five or more symptoms for more than five days. Fever, earache, and vomiting were the symptoms most likely to cause parents to rate their infant as ill. Earache was the symptom that triggered doctor contact most immediately. The parent-rated illness severity was strongly related to the tendency to contact a doctor. However, this association was markedly weaker when adjustment was made for the infant not eating normally, having a cough, or running a fever. Conclusion Specific symptoms such as fever, earache, and vomiting were strongly associated with the probability of parents rating the infant as ill. An earache would cause the parents to contact a doctor. Fever and vomiting were other symptoms triggering doctor contacts. First, these symptoms could cause the parents to want a doctor's expert evaluation of the infant's illness; second, the parents could expect medication to be necessary; or third, it could just be difficult for the parents to handle the ill infant. PMID:21591836
Rosen, L N
The relation between life events and psychiatric symptoms among wives of soldiers deployed to the Persian Gulf during Operation Desert Storm (ODS) was examined. Psychiatric symptoms were measured, using the 25-item Hopkins Symptom Checklist (HSCL), at two times, once while the soldiers were away and a second time several months after they returned. In a multiple regression analysis, symptoms at Time 2 were predicted by post-Desert Storm events as well as by events and emotional stressors that occurred during the military operation. The strongest predictor of post-Desert Storm events was pre-Desert Storm events. The impact of the deployment was also assessed on the basis of respondents' symptom profiles over time. Although 70% of the respondents were symptomatic during the deployment, 40% had recovered by Time 2; only 24% were symptomatic at both times. Even in the latter group, there was an improvement in symptoms between Time 1 (T1) and Time 2 (T2). PMID:8789649
The Influence of Depression, Anxiety and Somatization on the Clinical Symptoms and Treatment Response in Patients with Symptoms of Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia
This is the first study to investigate the influence of depression, anxiety and somatization on the treatment response for lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH). The LUTS/BPH patients were evaluated with the Korean versions of the International Prostate Symptom Score (IPSS), the Patient Health Questionnaire-9 (PHQ-9), the 7-item Generalized Anxiety Disorder Scale (GAD-7) and the PHQ-15. The primary endpoint was a responder rate defined by the total score of IPSS (? 7) at the end of treatment. The LUTS/BPH severity was significantly higher in patients with depression (whole symptoms P = 0.024; storage sub-symptom P = 0.021) or somatization (P = 0.024) than in those without, while the quality of life (QOL) was significantly higher in patients with anxiety (P = 0.038) than in those without. Anxious patients showed significantly higher proportion of non-response (odds ratio [OR], 3.294, P = 0.022) than those without, while somatic patients had a trend toward having more non-responders (OR, 2.552, P = 0.067). Our exploratory results suggest that depression, anxiety and somatization may have some influences on the clinical manifestation of LUTS/BPH. Further, anxious patients had a lower response to treatment in patients with LUTS/BPH. Despite of limitations, the present study demonstrates that clinicians may need careful evaluation of psychiatric symptoms for proper management of patients with LUTS/BPH. Graphical Abstract PMID:25120327
Im, Eun-Ok; Ko, Young; Chee, Wonshik
Our purpose for this study was to identify the clusters of midlife women by menopausal symptoms in a multi-ethnic sample, and to determine ethnic differences in the clusters. This was a secondary analysis of the data from 501 women in a larger Internet study on menopausal symptom experience. The data were analyzed using factor analysis, hierarchical cluster analysis, and multinominal logistic analysis. A three cluster solution was adopted (F=575.71, p<.01). The clusters differed significantly in the country of birth and ethnicity (p<.05). Only in the low symptomatic cluster, there were significant ethnic differences in menopausal symptoms. PMID:23980651
Vernberg, E M; Silverman, W K; La Greca, A M; Prinstein, M J
The authors used an integrative conceptual model to examine the emergence of posttraumatic stress disorder (PTSD) symptoms in 568 elementary school-age children 3 months after Hurricane Andrew. The model included 4 primary factors: Exposure to Traumatic Events, Child Characteristics, Access to Social Support, and Children's Coping. Overall, 62% of the variance in children's self-reported PTSD symptoms was accounted for by the 4 primary factors, and each factor improved overall prediction of symptoms when entered in the analyses in the order specified by the conceptual model. The findings suggest that the conceptual model may be helpful to organize research and intervention efforts in the wake of natural disasters. PMID:8723005
Teixeira, Emidio Oliveira; Fonseca, Marconi Teixeira
Introduction?Superior semicircular canal dehiscence syndrome is mainly characterized by vestibular symptoms induced by intense sound stimuli or pressure changes, which occur because of dehiscence of the bony layer covering the superior semicircular canal. Case Report?Here, we report a case of the syndrome with pulsatile tinnitus and ear fullness, in the absence of vestibular symptoms. Discussion?Signs and symptoms of the syndrome are rarely obvious, leading to the requirement for a minimum workup to rule out or make diagnosis more probable and thus avoid misconduct. PMID:25992092
Teixeira, Emidio Oliveira; Fonseca, Marconi Teixeira
Introduction?Superior semicircular canal dehiscence syndrome is mainly characterized by vestibular symptoms induced by intense sound stimuli or pressure changes, which occur because of dehiscence of the bony layer covering the superior semicircular canal. Case Report?Here, we report a case of the syndrome with pulsatile tinnitus and ear fullness, in the absence of vestibular symptoms. Discussion?Signs and symptoms of the syndrome are rarely obvious, leading to the requirement for a minimum workup to rule out or make diagnosis more probable and thus avoid misconduct. PMID:25992092
William T. Randazzo; Samantha Dockray; Elizabeth J. Susman
Objective To investigate the hypothalamic pituitary adrenal (HPA) axis response to a stressor in adolescents with inattentive type attention-deficit\\u000a hyperactivity disorder symptoms (ADHD-I).\\u000a \\u000a \\u000a \\u000a Method Salivary cortisol was measured in threshold inattentive (TI, n = 7), moderately inattentive (MI, n = 13) and no symptom (comparison) (n = 19) groups of healthy, young adolescents, based on symptom counts, prior to and after an induced social\\/cognitive stressor.\\u000a \\u000a \\u000a \\u000a Results The TI group
Yu-Mi Na; Kwang-Soo Kim; Kyoung-Uk Lee; Jeong-Ho Chae; Jin-Ho Kim; Dai-Jin Kim; Won-Myong Bahk; Yun-Sig Jang; Ae-Kyoung Lee; Young Sup Woo; Pyeoung-Soo Lee
Purpose: To evaluate the relationship between depressive symptoms and health care costs in outpatients with chronic medical illnesses in Korea, we screened for depressive symptoms in 1,118 patients with a chronic medical illness and compared the severity of somatic symptoms and health care costs. Patients and Methods: Data were compared between outpatients with depressive symptoms and those without depressive symptoms.
Blazer, Dan G.; And Others
Investigates paranoia in older adults. In cross-sectional analyses, symptoms were strongly associated with black race, lower income and education, less exercise, and more depressive symptoms. In longitudinal analysis, three years following initial interview, symptoms were predicted by baseline paranoid symptoms, education and depressive symptoms…
and maintenance of posttraumatic stress disorder (PTSD) symptoms. The present study utilized regression analysis to examine the unique relationships between various trauma-related cognitions and PTSD symptoms after to PTSD symptom severity. Gender and anxiety symptoms were also related to PTSD symptom severity
Jones, Deborah J.; O'Connell, Cara; Gound, Mary; Heller, Laurie; Forehand, Rex
In this study we examined the association of optimism and depressive symptoms with self-reported physical symptoms in 241 low-income, inner-city African American women with or without a chronic illness (HIV). Although optimism was not a unique predictor of self-reported physical symptoms over and above depressive symptoms, optimism interacted with…
Leistikow, Bruce N.
: Fevers> 100° F URI Symptoms no Fevers PLUS: Respiratory Symptoms (Cough with or without sore throat nausea/diarrhea. ~ ASSUME INFLUENZA DO NOT COME TO WORK ~ ~ ! ~ If Fevers> 100°F develop: If symptoms are not ASSUME INFLUENZA progressive and !!Q fevers develop: I Assume URI. If severe symptoms w/o fevers: Stay
Marine Corps Inst., Washington, DC.
Developed as part of the Marine Corps Institute (MCI) correspondence training program, this course on warehousing operations is designed to provide instruction in the procedures used in warehousing operations. Introductory materials include specific information for MCI students and a study guide (guidelines to complete the course). The 22-hour…
Denning, Peter J.; Brown, Robert L.
A computer operating system spans multiple layers of complexity, from commands entered at a keyboard to the details of electronic switching. In addition, the system is organized as a hierarchy of abstractions. Various parts of such a system and system dynamics (using the Unix operating system as an example) are described. (JN)
Loffeld, R J L F
Gastro-oesophageal reflux disease is one of the most common medical problems in daily practice, with many guidelines on diagnosis and treatment available. The prevalence and incidence of reflux disease are rising. In a period of 10 years, the incidence of reflux oesophagitis has almost doubled, as has the number of pills and tablets of acid-suppressive therapy sold. The decreased number of patients with severe reflux oesophagitis is indicative of increased public awareness. Heartburn and regurgitation are the hallmarks of reflux disease. The symptom score in patients with the mild reflux oesophagitis is significantly higher than it is in patients presenting with severe oesophagitis, NERD or Barrett's oesophagus. Patients with mild oesophagitis also suffer from more reflux. Dysphagia is often the only presenting symptom in severe oesophagitis. Patients with reflux oesophagitis have a significantly higher symptom score than patients with Barrett's oesophagus. The scores for heartburn and acid regurgitation are significantly higher in reflux oesophagitis. The primary goal of treatment is complete clinical remission and prevention of long-term complications. In a study with a follow-up of 4.5 to 7.5 years in patients with reflux oesophagitis it was shown that 85% still used acid-suppressive therapy, mostly on a daily basis. However, the majority were never completely free of reflux. Despite the fact that the degree of reflux oesophagitis correlates with the risk of relapse, also patients in whom initially the most severe grade of reflux oesophagitis (grades III and IV) was diagnosed no longer use medication. Treatment of reflux disease with acid suppressants is a major component in national and international drug budgets, and health-care authorities and insurance companies are eager to reduce these budgets. Since diagnosis and treatment are already discussed in many guidelines, cut-backs could be achieved in patients on maintenance therapy. For this reason, more data have to be assessed on therapy outcome in cases of chronic maintenance therapy. Guidelines for maintenance or on-demand therapy are necessary. PMID:16782615
Albertson, Orrie E.; And Others
This book is intended to be a reference or textbook on the operation of wastewater treatment plants. The book contains thirty-one chapters and three appendices and includes the description, requirements, and latest techniques of conventional unit process operation, as well as the symptoms and corrective measures regarding process problems. Process…
Rodriguez, Erin M; Donenberg, Geri R; Emerson, Erin; Wilson, Helen W; Javdani, Shabnam
Adolescents' interpersonal skills are associated with fewer teen depressive symptoms and more positive parenting, but little is known about how teens' externalizing problems moderate these relationships. This study examines links among teens' interpersonal skills, parenting, and withdrawn-depressed symptoms in adolescents seeking outpatient psychiatric treatment with elevated or non-elevated externalizing problems. Adolescents (N = 346; 42 % female; 61 % African-American) ages 12-19 years old (M = 14.9; SD = 1.8) and parents completed assessments at baseline and 6 months. At baseline parents and teens reported on teen withdrawn-depressed and externalizing symptoms, and were observed interacting to assess teen interpersonal skills. At 6 months adolescents reported on parenting, and parents and teens reported on teen withdrawn-depressed symptoms. Structural equation modeling tested two models (one with teen reported symptoms and one with parent reported symptoms). Model fit was better for youth with elevated externalizing problems regardless of reporter. For youth with elevated externalizing problems, baseline teen positive interpersonal skills were not directly associated with 6-month withdrawn-depressed symptoms, but more positive parenting was associated with fewer withdrawn-depressed symptoms. In the teen report model, more positive teen interpersonal skills were associated with more positive parenting, and there was a trend for parenting to indirectly account for the relationship between interpersonal skills and withdrawn-depressed symptoms. The findings extend research on the role of externalizing problems in teens' depression risk. Interventions for depression that target interpersonal skills may be particularly effective in youth with elevated externalizing problems. PMID:25698655
Bui, Eric; Rodgers, Rachel; Simon, Naomi M; Jehel, Louis; Metcalf, Christina A; Birmes, Philippe; Schmitt, Laurent
Body piercing, which is prevalent in young adults, has been suggested to be associated with features usually related to posttraumatic stress disorder (PTSD) such as high-risk behaviours and psychopathological symptoms and might be motivated by a wish to deal with prior traumatic experiences. However, to date, no research has investigated the relationship between this practice and PTSD symptoms. The present research aims to investigate the possible relationship between body piercing and PTSD symptoms in French-speaking young adults. According to our results, having two or more body piercings was associated with a twofold increased risk for scoring above the cut-off score for PTSD on the PTSD checklist. Our findings suggest that two or more body piercings might serve as an identifiable marker for PTSD symptoms and may have important implications for clinical screening. PMID:22499241
... Menopausal Symptoms and Complementary Health Practices : What the Science Says September 2013 Since the 2005 NIH panel’s ... products and practices in the context of rigorous science, training complementary health researchers, and disseminating authoritative information ...
... National Institute on Deafness and Other Communication Disorders Tinnitus: A Common Symptom Tinnitus, common in older people, is a ringing, roaring, ... or both ears and be loud or soft. Tinnitus is also common in members of the military ...
Tahiroglu, Aysegul Yolga; Firat, Sunay; Avci, Ay?e
There are many comorbid disorders associated with autism spectrum disorders in child and adolescent population. Although obsessive compulsive disorder and autism spectrum disorders (ASD) comorbidity has common in clinical practice, there are few reports about psychopharmacological treatment for obsessive compulsive symptoms in children with ASD in the literacy. We report a successful treatment case with aripiprazole in Asperger's Disorder with obsessive compulsive symptoms. The Yale Brown Obsessive Compulsive Scale was performed to assess symptom variety. This case report supports the effectiveness of aripiprazole in treatment of obsessive compulsive symptoms in Asperger's Disorder or ASDs. Aripiprazole may be beneficial to obsessive compulsive disorder comorbid autism spectrum disorders in child and adolescent age group. PMID:23429759
... be related to DVT itself or pulmonary embolism (PE). See your doctor right away if you have ... or symptoms of either condition. Both DVT and PE can cause serious, possibly life-threatening problems if ...
Bacon, Cynthia Thornton; Hughes, Linda C.; Mark, Barbara A
We tested a theoretical model of the relationships of hospital context, nursing unit structure, and patient characteristics to patients’ perceptions of the extent to which nurses met their expectations for management of troubling symptoms. In our sample of 2,720 patients randomly selected from 278 nursing units in 143 hospitals, we found that patient age was positively associated with patients’ perceptions of symptom management. The proportion of registered nurses as caregivers on the unit was not a significant predictor of symptom management, but better work conditions on the unit (nurses’ autonomy, participation in decision-making, and collaboration with other disciplines [relational coordination]) significantly contributed to patients’ perceptions of better symptom management. PMID:19204940
Project, a community-based longitudinal study of aging and dementia in northern Manhattan. PARTICIPANTS Columbia Aging Project (WHICAP),3 but because depressive symptoms did not predict greater risk of MCI
FELTON, JULIA; COLE, DAVID A.; TILGHMAN-OSBORNE, CARLOS; MAXWELL, MELISSA A.
The Diagnostic and Statistical Manual of Mental Disorders lists weight gain or weight loss as a symptom of depression at all ages, but no study of adolescent depression has examined its relation to actual (not just self-reported) weight change. In the current longitudinal study, 215 adolescents provided physical and self-report measures of change in weight, body mass, and body fat over a 4-month time interval. They also completed psychological measures of body dissatisfaction, problematic eating attitudes, and depressive symptoms. The relation between physical measures of weight change and depressive symptoms varied with age. These relations were explained by individual differences in body dissatisfaction, eating attitudes, and behaviors, leading to questions about weight change as a symptom of depression in adolescence. PMID:20102656
Francis, Sarah E.; Bearman, Sarah Kate
Extensive research has linked youth depression symptoms to low levels of perceived control, using measures that reflect primary control (i.e., influencing objective conditions to make them fit one's wishes). We hypothesized that depressive symptoms are also linked to low levels of secondary control (i.e., influencing the psychological impact of objective conditions by adjusting oneself to fit them). To test the hypothesis, we developed the Secondary Control Scale for Children (SCSC), examined its psychometrics, and used it to assess the secondary control-depression symptomatology association. In a large adolescent sample, the SCSC showed factorial integrity, internal consistency, test-retest stability, convergent and discriminant validity, and accounted for more than 40% of the variance in depression symptoms. Consistent with evidence on risk and gender, depression symptoms were more strongly associated with secondary control in girls and primary control in boys. Assessing secondary control may help us understand youth depression vulnerability in girls and boys. PMID:20640503
Lang, F U; Dudeck, M; Becker, T; Jäger, M
The organic personality disorder is primarily characterized by a change of premorbid behavior due to an organic impairment or disease of the central nervous system. German psychopathological preliminary work had a determining influence on the current diagnostic concepts in the international classification of diseases 10 (ICD-10) and the diagnostic and statistical manual of mental disorders 5 (DSM-5). An analysis of the literature in the MEDLINE database shows that most studies can be found for traumatic brain injury and epilepsy. The most common symptoms described were symptoms of depression, emotional instability, irritability and impulsive behavior. Psychopathological symptoms were not related to the etiopathogenesis but showed some relation to the neuroanatomical location of functional disorders or damages. Only few publications on treatment strategies were found. The empirical findings point to the necessity of multiaxial diagnostic measures to distinguish between the levels of etiology and symptomatology. Therapeutic interventions should be planned on the basis of psychopathological symptoms. PMID:25492699
The study used multiple-group confirmatory factor analysis (CFA) and multiple indicators multiple causes (MIMIC) procedures to examine the measurement and construct equivalencies for father and mother ratings of ADHD symptoms, recoded as binary scores. Fathers (N = 387) and mothers (N = 411) rated their primary school-aged children on the Disruptive Behavior Rating Scale (Barkley & Murphy, 1998). For the multiple-group CFA analyses, the results involving differences in practical fit indices supported full measurement and construct equivalencies, whereas the chi-square difference test showed lack of equivalency in five symptoms for factor loadings, four symptoms for error variance, and the variance and mean scores for the hyperactivity-impulsivity factor. For the MIMIC analyses, six symptoms lacked equivalency for thresholds. These findings extend existing data in this area. The theoretical, psychometric and clinical implications of the findings are discussed. PMID:19941051
... MD, FAAAAI Seasonal allergic rhinitis known as hay fever is caused by pollen carried in the air ... mouth, throat, eyes or ears. To control hay fever symptoms, it is important to monitor pollen counts ...
... Twitter. What Are the Signs and Symptoms of Marfan Syndrome? Marfan syndrome can affect many parts of ... many complications, some of which are life threatening. Marfan Traits Marfan syndrome often affects the long bones ...
Jenkins, Paul E; Rienecke, Renee D; Conley, Colleen S; Meyer, Caroline; Blissett, Jacqueline M
Although a number of studies have looked at what factors might mediate the relationship between symptoms and quality of life (QoL) in a number of psychiatric disorders, little research has addressed this issue in eating disorders. In the current study, female undergraduates (N = 339) completed questionnaires assessing eating disorder symptoms, social support, coping, QoL, and psychosocial impairment. Perceived family support and levels of substance misuse as a way of coping were identified as mediators of the symptom-impairment relationship and, in addition, maladaptive coping also mediated the relationship with QoL. These results highlight the role of coping and social support in impairment resulting from eating disorder symptoms. PMID:25974054
Boele, Florien W; Rooney, Alasdair G; Grant, Robin; Klein, Martin
Patients with primary intrinsic brain tumors can experience neurological, cognitive, and psychiatric symptoms that greatly affect daily life. In this review, we focus on changes in personality and behavior, mood issues, hallucinations, and psychosis, because these are either difficult to recognize, to treat, or are understudied in scientific literature. Neurobehavioral symptoms are common, often multiple, and causation can be multifactorial. Although different symptoms sometimes require a different treatment approach, we advise a comprehensive treatment approach, including pharmacological treatment and/or psychotherapy where appropriate. Further research is needed to obtain a better estimate of the prevalence of psychiatric symptoms in glioma patients, and the extent to which these affect everyday functioning and family life.
van der Molen, Thys; Miravitlles, Marc; Kocks, Janwillem WH
Patients with chronic obstructive pulmonary disease (COPD) present with a variety of symptoms that significantly impair health-related quality of life. Despite this, COPD treatment and its management are mainly based on lung function assessments. There is increasing evidence that conventional lung function measures alone do not correlate well with COPD symptoms and their associated impact on patients’ everyday lives. Instead, symptoms should be assessed routinely, preferably by using patient-centered questionnaires that provide a more accurate guide to the actual burden of COPD. Numerous questionnaires have been developed in an attempt to find a simple and reliable tool to use in everyday clinical practice. In this paper, we review three such patient-reported questionnaires recommended by the latest Global Initiative for Chronic Obstructive Lung Disease guidelines, ie, the modified Medical Research Council questionnaire, the clinical COPD questionnaire, and the COPD Assessment Test, as well as other symptom-specific questionnaires that are currently being developed. PMID:24143085
Chao, Yin Xia; Chew, Lai Mun; Deng, Xiao; Tan, Eng-King
SUMMARY? Besides the classical motor symptoms, Parkinson's disease (PD) patients experience a wide range of nonmotor symptoms (NMS) throughout the disease course. However, due to the lack of recognition and understanding of the pathogenesis, NMS symptoms may be overlooked. Familial PD is a well-defined group that can provide a good model to investigate the mechanisms for both motor and NMS in PD. Some studies suggest that the frequency of NMS is not different between genetic and sporadic form of PD while others suggest that specific domains (such as neuropsychiatric symptoms) are more common in the genetic form. Early recognition of NMS may facilitate early diagnosis and monitoring of both sporadic and genetic PD. PMID:25894878
Bandettini, Peter A.
Is It a Cold or the Flu? Symptoms Cold Flu Fever Rare Usual; high (100°F to 102°F, occasionally with a cold Annual vaccination; antiviral medicines--see your doctor Complications Sinus congestion Middle ear
Bacon, Cynthia Thornton; Hughes, Linda C; Mark, Barbara A
We tested a theoretical model of the relationships of hospital context, nursing unit structure, and patient characteristics to patients' perceptions of the extent to which nurses met their expectations for management of troubling symptoms. In our sample of 2,720 patients randomly selected from 278 nursing units in 143 hospitals, we found that patient age was positively associated with patients' perceptions of symptom management. The proportion of registered nurses as caregivers on the unit was not a significant predictor of symptom management, but better work conditions on the unit (nurses' autonomy, participation in decision-making, and collaboration with other disciplines [relational coordination]) significantly contributed to patients' perceptions of better symptom management. PMID:19204940
Gsanger, Kristen Marie
, Ergis, & Allilaire, 2002). However, little research is available confirming the presence of these adverse patterns in children and adolescents manifesting similar depressive symptoms. Although research suggests that children and adolescents who exhibit...
Stern, Robert M.; Hu, Senqi; Vasey, Michael W.; Koch, Kenneth L.
The effects of repeated exposures to a rotating circular vection drum on the symptoms of motion sickness and tachygastria in humans were investigated. Subjects were sitting in a drum and were exposed to 15 min baseline (no rotation), followed by 15 min drum rotation at 60 deg/s, and, then, by 15 min recovery. Gastric myoelectric activity was continuously recorded with the electrogastrogram. Subjects who were exposed to the drum three times with intervals of 4-24 days all showed symptoms of tachygastria and failed to show an amelioration of motion sickness symptoms. On the other hand subjects who had only 48 h between the three sessions of drum exposure, experienced a reduction in motion-sickness symptoms and in tachygastsria upon repeated exposure to the drum, indicating that training effected a symptomatic and physiological adaptation. It is suggested that preflight adaptation to visual-vestibular sensory mismatch may reduce motion sickness in astronauts.
Colantuoni, Elizabeth; Mendez-Tellez, Pedro A.; Dinglas, Victor D.; Shanholtz, Carl; Husain, Nadia; Dennison, Cheryl R.; Herridge, Margaret S.; Pronovost, Peter J.; Needham, Dale M.
Rationale: Survivors of acute lung injury (ALI) frequently have substantial depressive symptoms and physical impairment, but the longitudinal epidemiology of these conditions remains unclear. Objectives: To evaluate the 2-year incidence and duration of depressive symptoms and physical impairment after ALI, as well as risk factors for these conditions. Methods: This prospective, longitudinal cohort study recruited patients from 13 intensive care units (ICUs) in four hospitals, with follow-up 3, 6, 12, and 24 months after ALI. The outcomes were Hospital Anxiety and Depression Scale depression score greater than or equal to 8 (“depressive symptoms”) in patients without a history of depression before ALI, and two or more dependencies in instrumental activities of daily living (“impaired physical function”) in patients without baseline impairment. Measurements and Main Results: During 2-year follow-up of 186 ALI survivors, the cumulative incidences of depressive symptoms and impaired physical function were 40 and 66%, respectively, with greatest incidence by 3-month follow-up; modal durations were greater than 21 months for each outcome. Risk factors for incident depressive symptoms were education 12 years or less, baseline disability or unemployment, higher baseline medical comorbidity, and lower blood glucose in the ICU. Risk factors for incident impaired physical function were longer ICU stay and prior depressive symptoms. Conclusions: Incident depressive symptoms and impaired physical function are common and long-lasting during the first 2 years after ALI. Interventions targeting potentially modifiable risk factors (e.g., substantial depressive symptoms in early recovery) should be evaluated to improve ALI survivors’ long-term outcomes. PMID:22161158
Renée Turzanski Fortner; Penelope Pekow; Nancy Dole; Glenn Markenson; Lisa Chasan-Taber
Prior studies of risk factors for depressive symptoms during pregnancy are sparse and the majority have focused on non-Hispanic\\u000a white women. Hispanics are the largest minority group in the US and have the highest birth rates. We examined associations\\u000a between pre and early pregnancy factors and depressive symptoms in early pregnancy among 921 participants in Proyecto Buena\\u000a Salud, an ongoing
B Isgar; M Harman; M D Kaye; P J Whorwell
The prevalence of symptoms suggestive of a motility disturbance similar to the irritable bowel syndrome was investigated in 98 patients with ulcerative colitis in remission, and a similar number of age- and sex-matched healthy controls. Thirty-three per cent of patients compared with 7% of controls fulfilled the criteria for such a syndrome (p<0·01). Contrary to expectations these symptoms were not
Lorraine Dennerstein; Emma C Dudley; John L Hopper; Janet R Guthrie; Henry G Burger
Objective: To identify symptoms that change in prevalence and severity during midlife and evaluate their relationships to menopausal status, hormonal levels, and other factors.Methods: In a longitudinal, population-based study of 438 Australian-born women observed for 7 years with an 89% retention rate, 172 advanced from premenopause to perimenopause or postmenopause. Annual measures included a 33-item symptom check list; psychosocial, lifestyle,
Jasper, Fabian; Egloff, Boris; Roalfe, Andrea; Witthöft, Michael
AIM: To investigate the latent structure of an irritable bowel syndrome (IBS) symptom severity scale in a population of healthy adults. METHODS: The Birmingham IBS symptom questionnaire which consists of three symptom specific scales (diarrhea, constipation, pain) was evaluated by means of structural equation modeling. We compared the original 3-factor solution to a general factor model and a bifactor solution in a large internet sample of college students (n = 875). Statistical comparisons of competing models were conducted by means of ?2 difference tests. Regarding the evaluation of model fit, we examined the comparative fit index (CFI) and the Root Mean Square Error of Approximation (RMSEA). RESULTS: Results clearly favored a bifactor model of IBS symptom severity (CFI = 0.99, RMSEA = 0.05) which consisted of a strong general IBS somatization factor and three symptom specific factors (diarrhea, constipation, pain) based on the subscales of the Birmingham IBS symptom questionnaire. The fit indices of the competing one factor model (CFI = 0.85, RMSEA = 0.17) and three factor model (CFI = 0.97, RMSEA = 0.08) were clearly inferior. ?2 difference tests showed that the differences between the models were indeed significant in favor of the bifactor model (P < 0.001). Correlations of the four latent factors with measures of pain sensitivity, somatoform dissociation, fatigue severity, and demographic variables support the validity of our bifactor model of IBS specific symptom severity. CONCLUSION: The findings suggest that IBS symptom severity might best be understood as a continuous and multidimensional construct which can be reliably and validly assessed with the B-IBS. PMID:25574104
Eduardo A. Colón
Panic disorder is a common illness with significant impact on function and, at times, disabling consequences. Advances over\\u000a recent years have yielded potential pathophysiologic mechanisms, including neurotransmitter systems and neural substrates.\\u000a This article provides an overview of various models and hypotheses regarding the etiology of panic disorder. Because its symptoms\\u000a overlap with the symptoms of various medical disorders, this discussion
Kamaldeep Bhui; Abdisalama Abdi; Mahad Abdi; Stephen Pereira; Mohammed Dualeh; David Robertson; Ganesh Sathyamoorthy; Hellena Ismail
. Background: Each refugee group experiences specific migration and resettlement experiences. There are no epidemiological data on risk\\u000a factors for psychiatric symptoms among adult Somalis in the UK. Methods: We interviewed a community sample of 180 Somalis. We assessed the relationship between symptoms of psychosis (BPRS), anxiety\\u000a and depression (SCL–90) and suicidal thinking (BDI) and migration-related experiences such as traumatic
Shevrin, Howard; Snodgrass, Michael; Brakel, Linda A W; Kushwaha, Ramesh; Kalaida, Natalia L; Bazan, Ariane
Our approach is based on a tri-partite method of integrating psychodynamic hypotheses, cognitive subliminal processes, and psychophysiological alpha power measures. We present ten social phobic subjects with three individually selected groups of words representing unconscious conflict, conscious symptom experience, and Osgood Semantic negative valence words used as a control word group. The unconscious conflict and conscious symptom words, presented subliminally and supraliminally, act as primes preceding the conscious symptom and control words presented as supraliminal targets. With alpha power as a marker of inhibitory brain activity, we show that unconscious conflict primes, only when presented subliminally, have a unique inhibitory effect on conscious symptom targets. This effect is absent when the unconscious conflict primes are presented supraliminally, or when the target is the control words. Unconscious conflict prime effects were found to correlate with a measure of repressiveness in a similar previous study (Shevrin et al., 1992, 1996). Conscious symptom primes have no inhibitory effect when presented subliminally. Inhibitory effects with conscious symptom primes are present, but only when the primes are supraliminal, and they did not correlate with repressiveness in a previous study (Shevrin et al., 1992, 1996). We conclude that while the inhibition following supraliminal conscious symptom primes is due to conscious threat bias, the inhibition following subliminal unconscious conflict primes provides a neurological blueprint for dynamic repression: it is only activated subliminally by an individual's unconscious conflict and has an inhibitory effect specific only to the conscious symptom. These novel findings constitute neuroscientific evidence for the psychoanalytic concepts of unconscious conflict and repression, while extending neuroscience theory and methods into the realm of personal, psychological meaning. PMID:24046743
Michael P. Jones; Lorrie M. Roth; Michael D. Crowell
INTRODUCTION:Reporting of symptoms and visceral sensations in functional dyspepsia is subjective and influenced by such factors as somatization and depression. To better understand the role of these factors in symptom reporting, somatization, somatosensory amplification, alexithymia, and depression were evaluated in patients with functional dyspepsia undergoing a water load test.METHODS:Sixty-seven controls and 103 patients with functional dyspepsia underwent a 5-min water
Ariane Park; Mark Stacy
Parkinson’s disease is a hypokinetic movement disorder with cardinal motor features of bradykinesia, resting tremor and rigidity.\\u000a However, non-motor symptoms, such as cognitive, neuropsychiatric, sleep, autonomic and sensory disturbances are gaining increasing\\u000a attention. These non-motor symptoms may be intrinsic to the disease pathology or may be results of treatment with dopaminergic\\u000a agents. Given that most, if not all, patients with
Christina M Gullion; A. John Rush
Background: This study has two goals: 1) to establish a generalizable model of the symptoms observed in outpatients with major depressive disorder (MDD); and 2) to compare symptom coverage of the Inventory of Depressive Symptomatology, Clinician-Rated (IDS-C) and Self-Report (IDS-SR) to that of the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI).Methods: A factor analysis of IDS-C, IDS-SR,
Igor I. Galynker; Jun Cai; Fukiat Ongseng; Howard Finestone; Eamon Dutta; Dragos Serseni
The purpose of the current study was to compare regional cerebral blood flow (rCBF) in patients with major depressive disorder (MOD) to that of healthy subjects and to examine the relationship between rCBF, depressive symptoms (DS) and negative symptoms (NS) in these patients. Methods: Eleven psychiatric inpatients with diag nosed (MOD)and 15 normal control subjects were administered the scale for
F. Larese Filon; A. Bosco; A. Fiorito; C. Negro; P. Barbina
Background: Natural rubber latex has become an important occupational health concern, particularly among health care workers, who for\\u000a protection are required to wear latex gloves when at work. This study evaluated the prevalence of latex-related symptoms and\\u000a sensitisation among a large group of health care workers in Trieste hospitals. Methods: We evaluated the prevalence of latex-related symptoms in 1,165 health