Sample records for t32 national research

  1. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien who...

  2. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien who...

  3. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien who...

  4. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien who...

  5. 32 CFR 1630.46 - Class 4-T: Treaty alien.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Class 4-T: Treaty alien. 1630.46 Section 1630.46 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM CLASSIFICATION RULES § 1630.46 Class 4-T: Treaty alien. In Class 4-T shall be placed any registrant who is an alien who...

  6. 32 CFR 37.1360 - Research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Research. 37.1360 Section 37.1360 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1360 Research. Basic, applied, and advanced research, as defined in this subpart. ...

  7. 32 CFR 37.1360 - Research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Research. 37.1360 Section 37.1360 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1360 Research. Basic, applied, and advanced research, as defined in this subpart. ...

  8. 32 CFR 37.1360 - Research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Research. 37.1360 Section 37.1360 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1360 Research. Basic, applied, and advanced research, as defined in this subpart. ...

  9. 32 CFR 37.1360 - Research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Research. 37.1360 Section 37.1360 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1360 Research. Basic, applied, and advanced research, as defined in this subpart. ...

  10. 32 CFR 37.1360 - Research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Research. 37.1360 Section 37.1360 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1360 Research. Basic, applied, and advanced research, as defined in this subpart. ...

  11. 32 CFR 37.1240 - Basic research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...

  12. 32 CFR 37.1240 - Basic research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...

  13. 32 CFR 37.1240 - Basic research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...

  14. 32 CFR 37.1240 - Basic research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...

  15. 32 CFR 37.1240 - Basic research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...

  16. 32 CFR 219.114 - Cooperative research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

  17. 32 CFR 219.114 - Cooperative research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

  18. 32 CFR 219.114 - Cooperative research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

  19. 32 CFR 219.114 - Cooperative research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

  20. 32 CFR 219.114 - Cooperative research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

  1. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Advanced research. 37.1210 Section 37.1210... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous to...

  2. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Advanced research. 37.1210 Section 37.1210... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous to...

  3. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Advanced research. 37.1210 Section 37.1210... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous to...

  4. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Advanced research. 37.1210 Section 37.1210... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous to...

  5. 32 CFR 37.1210 - Advanced research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Advanced research. 37.1210 Section 37.1210... research. Research that creates new technology or demonstrates the viability of applying existing technology to new products and processes in a general way. Advanced research is most closely analogous to...

  6. 32 CFR 37.1220 - Applied research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Applied research. 37.1220 Section 37.1220... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1220 Applied research... technology such as new materials, devices, methods and processes. It typically is funded in Research...

  7. 32 CFR 37.1220 - Applied research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Applied research. 37.1220 Section 37.1220... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1220 Applied research... technology such as new materials, devices, methods and processes. It typically is funded in Research...

  8. 32 CFR 37.1220 - Applied research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Applied research. 37.1220 Section 37.1220... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1220 Applied research... technology such as new materials, devices, methods and processes. It typically is funded in Research...

  9. 32 CFR 37.1220 - Applied research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Applied research. 37.1220 Section 37.1220... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1220 Applied research... technology such as new materials, devices, methods and processes. It typically is funded in Research...

  10. 32 CFR 37.1220 - Applied research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Applied research. 37.1220 Section 37.1220... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1220 Applied research... technology such as new materials, devices, methods and processes. It typically is funded in Research...

  11. Multivariate Analysis of Income Inequality: Data from 32 Nations.

    ERIC Educational Resources Information Center

    Stack, Steven

    To analyze income inequality in 32 nations, the research tested hypotheses based upon eight socioeconomic variables. The first seven variables, often tested in income research, were: political participation, industrial development, population growth, educational level, inflation rate, economic growth, and technological complexity. The eighth…

  12. 32 CFR 272.3 - Definition of basic research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...

  13. 32 CFR 272.3 - Definition of basic research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...

  14. 32 CFR 219.109 - IRB review of research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false IRB review of research. 219.109 Section 219.109...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.109 IRB review of research. (a) An IRB shall review and have authority to approve, require modifications in (to secure approval), or disapprove all research activities...

  15. 32 CFR 219.109 - IRB review of research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false IRB review of research. 219.109 Section 219.109...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.109 IRB review of research. (a) An IRB shall review and have authority to approve, require modifications in (to secure approval), or disapprove all research activities...

  16. 32 CFR 219.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Criteria for IRB approval of research. 219.111 Section 219.111 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.111 Criteria for IRB approval of research. (a...

  17. 46 CFR 32.40-15 - Construction-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Construction-T/ALL. 32.40-15 Section 32.40-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-15 Construction—T/ALL. All crew spaces are to be...

  18. 46 CFR 32.40-30 - Messrooms-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Messrooms-T/ALL. 32.40-30 Section 32.40-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-30 Messrooms—T/ALL. (a) Messrooms must be located as...

  19. 46 CFR 32.40-15 - Construction-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Construction-T/ALL. 32.40-15 Section 32.40-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-15 Construction—T/ALL. All crew spaces are to be...

  20. 46 CFR 32.40-30 - Messrooms-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Messrooms-T/ALL. 32.40-30 Section 32.40-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-30 Messrooms—T/ALL. (a) Messrooms must be located as...

  1. 46 CFR 32.40-45 - Lighting-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Lighting-T/ALL. 32.40-45 Section 32.40-45 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-45 Lighting—T/ALL. Each berth must have a light. ...

  2. 46 CFR 32.40-45 - Lighting-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Lighting-T/ALL. 32.40-45 Section 32.40-45 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-45 Lighting—T/ALL. Each berth must have a light. ...

  3. 46 CFR 32.15-5 - Whistles-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Whistles-T/ALL. 32.15-5 Section 32.15-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Navigation Equipment § 32.15-5 Whistles—T/ALL. (a) [Reserved] (b) On tankships contracted for on and after...

  4. 46 CFR 32.40-5 - Intent-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Intent-T/ALL. 32.40-5 Section 32.40-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-5 Intent—T/ALL. The accommodations provided for officers and crew on...

  5. 46 CFR 32.15-5 - Whistles-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Whistles-T/ALL. 32.15-5 Section 32.15-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Navigation Equipment § 32.15-5 Whistles—T/ALL. (a) [Reserved] (b) On tankships contracted for on and after...

  6. 46 CFR 32.40-5 - Intent-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Intent-T/ALL. 32.40-5 Section 32.40-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-5 Intent—T/ALL. The accommodations provided for officers and crew on...

  7. 46 CFR 32.53-5 - Operation-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Operation-T/ALL. 32.53-5 Section 32.53-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Inert Gas System § 32.53-5 Operation-T/ALL. Unless the cargo tanks are gas free, the master of each...

  8. 46 CFR 32.53-10 - General-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false General-T/ALL. 32.53-10 Section 32.53-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Inert Gas System § 32.53-10 General—T/ALL. (a) Each tankship to which this subpart applies must have an...

  9. 46 CFR 32.53-5 - Operation-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Operation-T/ALL. 32.53-5 Section 32.53-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Inert Gas System § 32.53-5 Operation-T/ALL. Unless the cargo tanks are gas free, the master of each...

  10. 46 CFR 32.53-10 - General-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false General-T/ALL. 32.53-10 Section 32.53-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Inert Gas System § 32.53-10 General—T/ALL. (a) Each tankship to which this subpart applies must have an...

  11. An Overview of Research and Development Projects at the AT&T National Teletraining Center.

    ERIC Educational Resources Information Center

    Chute, Alan G.; Balthazar, Lee B.

    Research and development projects at the AT&T (American Telephone and Telegraph Company) National Teletraining Center (NTC) are geared toward increasing understanding of the various psychological, sociological, ergonomic, and environmental factors involved in teletraining, and toward improving the ability to manage the distance learning…

  12. Challenges of T3 and T4 Translational Research

    ERIC Educational Resources Information Center

    Vukotich, Charles J., Jr.

    2016-01-01

    Translational research is a new and important way of thinking about research. It is a major priority of the National Institutes of Health (NIH) in the United States. NIH has created the Clinical and Translational Science Awards to promote this priority. NIH has defined T1 and T2 phases of translational research in the medical field, in order to…

  13. 46 CFR 32.15-30 - Radar-T/OC.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Radar-T/OC. 32.15-30 Section 32.15-30 Shipping COAST... Navigation Equipment § 32.15-30 Radar—T/OC. All tankships of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar...

  14. 46 CFR 32.15-30 - Radar-T/OC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Radar-T/OC. 32.15-30 Section 32.15-30 Shipping COAST... Navigation Equipment § 32.15-30 Radar—T/OC. All tankships of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar...

  15. 46 CFR 32.15-30 - Radar-T/OC.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Radar-T/OC. 32.15-30 Section 32.15-30 Shipping COAST... Navigation Equipment § 32.15-30 Radar—T/OC. All tankships of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar...

  16. 46 CFR 32.15-30 - Radar-T/OC.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Radar-T/OC. 32.15-30 Section 32.15-30 Shipping COAST... Navigation Equipment § 32.15-30 Radar—T/OC. All tankships of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar...

  17. 46 CFR 32.15-30 - Radar-T/OC.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Radar-T/OC. 32.15-30 Section 32.15-30 Shipping COAST... Navigation Equipment § 32.15-30 Radar—T/OC. All tankships of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar...

  18. 32 CFR 700.333 - The Chief of Naval Research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false The Chief of Naval Research. 700.333 Section 700... The Office of the Secretary of the Navy/the Staff Assistants § 700.333 The Chief of Naval Research. (a) The Chief of Naval Research shall command the Office of the Chief of Naval Research, the Office of...

  19. 32 CFR 700.333 - The Chief of Naval Research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false The Chief of Naval Research. 700.333 Section 700... The Office of the Secretary of the Navy/the Staff Assistants § 700.333 The Chief of Naval Research. (a) The Chief of Naval Research shall command the Office of the Chief of Naval Research, the Office of...

  20. 32 CFR 219.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... research). The IRB should not consider possible long-range effects of applying knowledge gained in the research (for example, the possible effects of the research on public policy) as among those research risks... 32 National Defense 2 2010-07-01 2010-07-01 false Criteria for IRB approval of research. 219.111...

  1. 46 CFR 32.15-10 - Sounding machines-T/OCL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Sounding machines-T/OCL. 32.15-10 Section 32.15-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Navigation Equipment § 32.15-10 Sounding machines—T/OCL. All mechanically propelled vessels in...

  2. 46 CFR 32.15-10 - Sounding machines-T/OCL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Sounding machines-T/OCL. 32.15-10 Section 32.15-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Navigation Equipment § 32.15-10 Sounding machines—T/OCL. All mechanically propelled vessels in...

  3. 46 CFR 32.40-55 - Insect screens-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Insect screens-T/ALL. 32.40-55 Section 32.40-55 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-55 Insect screens—T/ALL. Provisions shall be made to protect the crew quarters against the admission of insects. ...

  4. 46 CFR 32.40-55 - Insect screens-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Insect screens-T/ALL. 32.40-55 Section 32.40-55 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-55 Insect screens—T/ALL. Provisions shall be made to protect the crew quarters against the admission of insects. ...

  5. 46 CFR 32.53-30 - Positive pressure-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Positive pressure-T/ALL. 32.53-30 Section 32.53-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Inert Gas System § 32.53-30 Positive pressure—T/ALL. Each inert gas system must be designed to...

  6. 46 CFR 32.53-30 - Positive pressure-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Positive pressure-T/ALL. 32.53-30 Section 32.53-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Inert Gas System § 32.53-30 Positive pressure—T/ALL. Each inert gas system must be designed to...

  7. 45 CFR 303.32 - National Medical Support Notice.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true National Medical Support Notice. 303.32 Section 303... SERVICES STANDARDS FOR PROGRAM OPERATIONS § 303.32 National Medical Support Notice. (a) Mandatory State... specified under paragraph (c) of this section for the use, where appropriate, of the National Medical...

  8. 46 CFR 32.40-40 - Other spaces-T/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Other spaces-T/ALL. 32.40-40 Section 32.40-40 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-40 Other spaces—T/ALL. Each vessel must have— (a... with hot and cold fresh water; (b) Recreation spaces; and (c) A space or spaces of adequate size...

  9. 46 CFR 32.40-40 - Other spaces-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Other spaces-T/ALL. 32.40-40 Section 32.40-40 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-40 Other spaces—T/ALL. Each vessel must have— (a... with hot and cold fresh water; (b) Recreation spaces; and (c) A space or spaces of adequate size...

  10. 46 CFR 32.40-40 - Other spaces-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Other spaces-T/ALL. 32.40-40 Section 32.40-40 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-40 Other spaces—T/ALL. Each vessel must have— (a... with hot and cold fresh water; (b) Recreation spaces; and (c) A space or spaces of adequate size...

  11. 46 CFR 32.40-40 - Other spaces-T/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Other spaces-T/ALL. 32.40-40 Section 32.40-40 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-40 Other spaces—T/ALL. Each vessel must have— (a... with hot and cold fresh water; (b) Recreation spaces; and (c) A space or spaces of adequate size...

  12. 46 CFR 32.40-40 - Other spaces-T/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Other spaces-T/ALL. 32.40-40 Section 32.40-40 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-40 Other spaces—T/ALL. Each vessel must have— (a... with hot and cold fresh water; (b) Recreation spaces; and (c) A space or spaces of adequate size...

  13. 46 CFR 32.56-35 - Doors-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Doors-T/ALL. 32.56-35 Section 32.56-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS... Doors—T/ALL. (a) Casing doors in category A machinery spaces and all elevator doors must be self-closing...

  14. 46 CFR 32.56-1 - Application-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Application-T/ALL. 32.56-1 Section 32.56-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-1 Application—T/ALL. (a)This subpart applies to all tankships that have a keel laying date on or...

  15. 46 CFR 32.56-5 - General-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false General-T/ALL. 32.56-5 Section 32.56-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS... General—T/ALL. (a) Except as provided in paragraphs (c) and (d) of this section, each category A machinery...

  16. 46 CFR 32.56-1 - Application-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Application-T/ALL. 32.56-1 Section 32.56-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-1 Application—T/ALL. (a)This subpart applies to all tankships that have a keel laying date on or...

  17. 46 CFR 32.56-5 - General-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false General-T/ALL. 32.56-5 Section 32.56-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS... General—T/ALL. (a) Except as provided in paragraphs (c) and (d) of this section, each category A machinery...

  18. 46 CFR 32.56-35 - Doors-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Doors-T/ALL. 32.56-35 Section 32.56-35 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS... Doors—T/ALL. (a) Casing doors in category A machinery spaces and all elevator doors must be self-closing...

  19. 46 CFR 32.40-35 - Hospital space-T/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Hospital space-T/ALL. 32.40-35 Section 32.40-35 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-35 Hospital space—T/ALL. (a) Each vessel which in the... crew of 12 or more, must be provided with a hospital space. This space must be situated with due regard...

  20. 46 CFR 32.40-35 - Hospital space-T/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Hospital space-T/ALL. 32.40-35 Section 32.40-35 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-35 Hospital space—T/ALL. (a) Each vessel which in the... crew of 12 or more, must be provided with a hospital space. This space must be situated with due regard...

  1. 46 CFR 32.40-35 - Hospital space-T/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Hospital space-T/ALL. 32.40-35 Section 32.40-35 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-35 Hospital space—T/ALL. (a) Each vessel which in the... crew of 12 or more, must be provided with a hospital space. This space must be situated with due regard...

  2. 46 CFR 32.40-35 - Hospital space-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Hospital space-T/ALL. 32.40-35 Section 32.40-35 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-35 Hospital space—T/ALL. (a) Each vessel which in the... crew of 12 or more, must be provided with a hospital space. This space must be situated with due regard...

  3. 46 CFR 32.40-35 - Hospital space-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Hospital space-T/ALL. 32.40-35 Section 32.40-35 Shipping... REQUIREMENTS Accommodations for Officers and Crew § 32.40-35 Hospital space—T/ALL. (a) Each vessel which in the... crew of 12 or more, must be provided with a hospital space. This space must be situated with due regard...

  4. RGC-32 is a novel regulator of the T-lymphocyte cell cycle.

    PubMed

    Tegla, Cosmin A; Cudrici, Cornelia D; Nguyen, Vinh; Danoff, Jacob; Kruszewski, Adam M; Boodhoo, Dallas; Mekala, Armugam P; Vlaicu, Sonia I; Chen, Ching; Rus, Violeta; Badea, Tudor C; Rus, Horea

    2015-06-01

    We have previously shown that RGC-32 is involved in cell cycle regulation in vitro. To define the in vivo role of RGC-32, we generated RGC-32 knockout mice. These mice developed normally and did not spontaneously develop overt tumors. To assess the effect of RGC-32 deficiency on cell cycle activation in T cells, we determined the proliferative rates of CD4(+) and CD8(+) T cells from the spleens of RGC-32(-/-) mice, as compared to wild-type (WT, RGC-32(+/+)) control mice. After stimulation with anti-CD3/anti-CD28, CD4(+) T cells from RGC-32(-/-) mice displayed a significant increase in [(3)H]-thymidine incorporation when compared to WT mice. In addition, both CD4(+) and CD8(+) T cells from RGC-32(-/-) mice displayed a significant increase in the proportion of proliferating Ki67(+) cells, indicating that in T cells, RGC-32 has an inhibitory effect on cell cycle activation induced by T-cell receptor/CD28 engagement. Furthermore, Akt and FOXO1 phosphorylation induced in stimulated CD4(+) T-cells from RGC-32(-/-) mice were significantly higher, indicating that RGC-32 inhibits cell cycle activation by suppressing FOXO1 activation. We also found that IL-2 mRNA and protein expression were significantly increased in RGC-32(-/-) CD4(+) T cells when compared to RGC-32(+/+) CD4(+) T cells. In addition, the effect of RGC-32 on the cell cycle and IL-2 expression was inhibited by pretreatment of the samples with LY294002, indicating a role for phosphatidylinositol 3-kinase (PI3K). Thus, RGC-32 is involved in controlling the cell cycle of T cells in vivo, and this effect is mediated by IL-2 in a PI3K-dependent fashion. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of the...

  6. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of the...

  7. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of the...

  8. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of the...

  9. 32 CFR 1602.3 - Aliens and nationals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Aliens and nationals. 1602.3 Section 1602.3 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.3 Aliens and nationals. (a) The term alien means any person who is not a citizen or national of the...

  10. 32 CFR 219.119 - Research undertaken without the intention of involving human subjects.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Research undertaken without the intention of involving human subjects. 219.119 Section 219.119 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.119 Research...

  11. 45 CFR 303.32 - National Medical Support Notice.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false National Medical Support Notice. 303.32 Section... HUMAN SERVICES STANDARDS FOR PROGRAM OPERATIONS § 303.32 National Medical Support Notice. (a) Mandatory... Medical Support Notice (NMSN), to enforce the provision of health care coverage for children of...

  12. 46 CFR 32.20-20 - Liquid level gaging-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Liquid level gaging-T/ALL. 32.20-20 Section 32.20-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Equipment Installations § 32.20-20 Liquid level gaging—T/ALL. On tankships, the construction or...

  13. 46 CFR 32.20-20 - Liquid level gaging-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Liquid level gaging-T/ALL. 32.20-20 Section 32.20-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Equipment Installations § 32.20-20 Liquid level gaging—T/ALL. On tankships, the construction or...

  14. 46 CFR 32.16-1 - Navigation bridge visibility-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Navigation bridge visibility-T/ALL. 32.16-1 Section 32..., AND HULL REQUIREMENTS Navigation Bridge Visibility § 32.16-1 Navigation bridge visibility-T/ALL. Each..., must meet the following requirements: (a) The field of vision from the navigation bridge, whether the...

  15. 46 CFR 32.40-50 - Heating and cooling-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Heating and cooling-T/ALL. 32.40-50 Section 32.40-50 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-50 Heating and cooling—T/ALL. (a) All manned spaces...

  16. 46 CFR 32.02-1 - Means of escape-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Means of escape-T/ALL. 32.02-1 Section 32.02-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Safety Requirements § 32.02-1 Means of escape—T/ALL. On all tankships where the plans and...

  17. 46 CFR 32.02-1 - Means of escape-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Means of escape-T/ALL. 32.02-1 Section 32.02-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Safety Requirements § 32.02-1 Means of escape—T/ALL. On all tankships where the plans and...

  18. Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).

    PubMed

    Chan, Derek V; Somani, Ally-Khan; Young, Andrew B; Massari, Jessica V; Ohtola, Jennifer; Sugiyama, Hideaki; Garaczi, Edina; Babineau, Denise; Cooper, Kevin D; McCormick, Thomas S

    2011-05-26

    Elevated numbers of regulatory T cells (T(regs)) have been implicated in certain cancers. Depletion of T(regs) has been shown to increase anti-tumor immunity. T(regs) also play a critical role in the suppression of autoimmune responses. The study of T(regs) has been hampered by a lack of adequate surface markers. Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). However, there is limited information regarding the processing of LRRC32 or the regulatory phenotype and functional activity of T(regs) expressing LRRC32. Using naturally-occurring freshly isolated T(regs), we demonstrate that low levels of LRRC32 are present intracellularly prior to activation and that freshly isolated LRRC32+ T(regs) are distinct from LRRC32- T(regs) with respect to the expression of surface CD62L. Using LRRC32 transfectants of HEK cells, we demonstrate that the N-terminus of LRRC32 is cleaved prior to expression of the protein at the cell surface. Furthermore, we demonstrate using a construct containing a deleted putative signal peptide region that the presence of a signal peptide region is critical to cell surface expression of LRRC32. Finally, mixed lymphocyte assays demonstrate that LRRC32+ T(regs) are more potent suppressors than LRRC32- T(regs). A cleaved signal peptide site in LRRC32 is necessary for surface localization of native LRRC32 following activation of naturally-occurring freshly-isolated regulatory T cells. LRRC32 expression appears to alter the surface expression of activation markers of T cells such as CD62L. LRRC32 surface expression may be useful as a marker that selects for more potent T(reg) populations. In summary, understanding the processing and expression of LRRC32 may provide insight into the mechanism of action of T(regs) and the refinement of immunotherapeutic strategies aimed at targeting these cells.

  19. 46 CFR 32.56-55 - Control spaces-T/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Control spaces-T/ALL. 32.56-55 Section 32.56-55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-55 Control spaces—T/ALL. Bulkheads and decks that separate control spaces from adjacent spaces...

  20. 46 CFR 32.56-55 - Control spaces-T/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Control spaces-T/ALL. 32.56-55 Section 32.56-55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-55 Control spaces—T/ALL. Bulkheads and decks that separate control spaces from adjacent spaces...

  1. 46 CFR 32.56-55 - Control spaces-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Control spaces-T/ALL. 32.56-55 Section 32.56-55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-55 Control spaces—T/ALL. Bulkheads and decks that separate control spaces from adjacent spaces...

  2. 46 CFR 32.56-55 - Control spaces-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Control spaces-T/ALL. 32.56-55 Section 32.56-55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-55 Control spaces—T/ALL. Bulkheads and decks that separate control spaces from adjacent spaces...

  3. 46 CFR 32.56-55 - Control spaces-T/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Control spaces-T/ALL. 32.56-55 Section 32.56-55 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-55 Control spaces—T/ALL. Bulkheads and decks that separate control spaces from adjacent spaces...

  4. 46 CFR 32.05-10 - Name of tankship-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Name of tankship-T/ALL. 32.05-10 Section 32.05-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Markings § 32.05-10 Name of tankship—T/ALL. Every tankship shall have the name marked upon each...

  5. 46 CFR 32.05-10 - Name of tankship-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Name of tankship-T/ALL. 32.05-10 Section 32.05-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Markings § 32.05-10 Name of tankship—T/ALL. Every tankship shall have the name marked upon each...

  6. 46 CFR 32.56-60 - Ventilation ducts-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Ventilation ducts-T/ALL. 32.56-60 Section 32.56-60 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-60 Ventilation ducts—T/ALL. (a) Each duct for ventilation of Category A machinery spaces that...

  7. 46 CFR 32.56-50 - Combustible veneers-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Combustible veneers-T/ALL. 32.56-50 Section 32.56-50 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-50 Combustible veneers—T/ALL. (a) Except as provided in paragraph (b) of this section combustible...

  8. 46 CFR 32.56-60 - Ventilation ducts-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Ventilation ducts-T/ALL. 32.56-60 Section 32.56-60 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-60 Ventilation ducts—T/ALL. (a) Each duct for ventilation of Category A machinery spaces that...

  9. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or...

  10. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or...

  11. 46 CFR 32.56-50 - Combustible veneers-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Combustible veneers-T/ALL. 32.56-50 Section 32.56-50 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-50 Combustible veneers—T/ALL. (a) Except as provided in paragraph (b) of this section combustible...

  12. 46 CFR 32.56-10 - Navigation positions-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Navigation positions-T/ALL. 32.56-10 Section 32.56-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-10 Navigation positions—T/ALL. (a) No navigation position may be above the cargo area unless it is...

  13. 46 CFR 32.56-15 - Deck spills-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Deck spills-T/ALL. 32.56-15 Section 32.56-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-15 Deck spills—T/ALL. A coaming or other barrier at least .3 meters (1 foot) higher than adjacent...

  14. 46 CFR 32.56-15 - Deck spills-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Deck spills-T/ALL. 32.56-15 Section 32.56-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-15 Deck spills—T/ALL. A coaming or other barrier at least .3 meters (1 foot) higher than adjacent...

  15. 46 CFR 32.56-10 - Navigation positions-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Navigation positions-T/ALL. 32.56-10 Section 32.56-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-10 Navigation positions—T/ALL. (a) No navigation position may be above the cargo area unless it is...

  16. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or... if draft stops of “B” Class construction are fitted between the ceiling or lining and the deck or...

  17. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or... if draft stops of “B” Class construction are fitted between the ceiling or lining and the deck or...

  18. 46 CFR 32.56-45 - Draft stops-T/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Draft stops-T/ALL. 32.56-45 Section 32.56-45 Shipping....56-45 Draft stops—T/ALL. (a) Where ceilings or linings are fitted in accommodation, service, or... if draft stops of “B” Class construction are fitted between the ceiling or lining and the deck or...

  19. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of Defense....123 Early termination of research support: Evaluation of applications and proposals. (a) The...

  20. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of Defense....123 Early termination of research support: Evaluation of applications and proposals. (a) The...

  1. 32 CFR 219.113 - Suspension or termination of IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Suspension or termination of IRB approval of research. 219.113 Section 219.113 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.113 Suspension or...

  2. 32 CFR 156.5 - National security positions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of Existing Personnel Security Clearances” dated December 12, 2005 (Copies available on the Internet... 32 National Defense 1 2014-07-01 2014-07-01 false National security positions. 156.5 Section 156.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE...

  3. 46 CFR 32.40-25 - Washrooms and toilet rooms-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... rooms. (e) Where more than 1 toilet is located in a space or compartment, each toilet must be separated... 46 Shipping 1 2011-10-01 2011-10-01 false Washrooms and toilet rooms-T/ALL. 32.40-25 Section 32.40..., AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-25 Washrooms and toilet rooms—T/ALL...

  4. 46 CFR 32.40-25 - Washrooms and toilet rooms-T/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... rooms. (e) Where more than 1 toilet is located in a space or compartment, each toilet must be separated... 46 Shipping 1 2012-10-01 2012-10-01 false Washrooms and toilet rooms-T/ALL. 32.40-25 Section 32.40..., AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-25 Washrooms and toilet rooms—T/ALL...

  5. 46 CFR 32.40-25 - Washrooms and toilet rooms-T/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... rooms. (e) Where more than 1 toilet is located in a space or compartment, each toilet must be separated... 46 Shipping 1 2014-10-01 2014-10-01 false Washrooms and toilet rooms-T/ALL. 32.40-25 Section 32.40..., AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-25 Washrooms and toilet rooms—T/ALL...

  6. 46 CFR 32.40-25 - Washrooms and toilet rooms-T/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... rooms. (e) Where more than 1 toilet is located in a space or compartment, each toilet must be separated... 46 Shipping 1 2013-10-01 2013-10-01 false Washrooms and toilet rooms-T/ALL. 32.40-25 Section 32.40..., AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-25 Washrooms and toilet rooms—T/ALL...

  7. 46 CFR 32.40-25 - Washrooms and toilet rooms-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... rooms. (e) Where more than 1 toilet is located in a space or compartment, each toilet must be separated... 46 Shipping 1 2010-10-01 2010-10-01 false Washrooms and toilet rooms-T/ALL. 32.40-25 Section 32.40..., AND HULL REQUIREMENTS Accommodations for Officers and Crew § 32.40-25 Washrooms and toilet rooms—T/ALL...

  8. 36 CFR 7.32 - Pictured Rocks National Lakeshore.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Pictured Rocks National... INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.32 Pictured Rocks National Lakeshore... Pictured Rocks National Lakeshore. The designated routes for snowmobiles will be confined to the frozen...

  9. 36 CFR 7.32 - Pictured Rocks National Lakeshore.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Pictured Rocks National... INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.32 Pictured Rocks National Lakeshore... Pictured Rocks National Lakeshore. The designated routes for snowmobiles will be confined to the frozen...

  10. 36 CFR 7.32 - Pictured Rocks National Lakeshore.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Pictured Rocks National... INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.32 Pictured Rocks National Lakeshore... Pictured Rocks National Lakeshore. The designated routes for snowmobiles will be confined to the frozen...

  11. 36 CFR 230.32 - National program administration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false National program... AGRICULTURE STATE AND PRIVATE FORESTRY ASSISTANCE Forest Land Enhancement Program § 230.32 National program... three geographic funding areas based on the criteria set out in the Forest Service Manual Chapter 3310...

  12. 36 CFR 230.32 - National program administration.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false National program... AGRICULTURE STATE AND PRIVATE FORESTRY ASSISTANCE Forest Land Enhancement Program § 230.32 National program... three geographic funding areas based on the criteria set out in the Forest Service Manual Chapter 3310...

  13. 10 CFR 32.201 - Serialization of nationally tracked sources.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Serialization of nationally tracked sources. 32.201 Section 32.201 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER CERTAIN ITEMS CONTAINING BYPRODUCT MATERIAL Specifically Licensed Items § 32.201 Serialization of...

  14. 10 CFR 32.201 - Serialization of nationally tracked sources.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Serialization of nationally tracked sources. 32.201 Section 32.201 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER CERTAIN ITEMS CONTAINING BYPRODUCT MATERIAL Specifically Licensed Items § 32.201 Serialization of...

  15. 32 CFR 147.24 - The national agency check.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false The national agency check. 147.24 Section 147.24 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... reinvestigations. It consists of a review of; (a) Investigative and criminal history files of the FBI, including a...

  16. 32 CFR 147.24 - The national agency check.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false The national agency check. 147.24 Section 147.24 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... reinvestigations. It consists of a review of; (a) Investigative and criminal history files of the FBI, including a...

  17. 32 CFR 147.24 - The national agency check.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false The national agency check. 147.24 Section 147.24 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... reinvestigations. It consists of a review of; (a) Investigative and criminal history files of the FBI, including a...

  18. 32 CFR 147.24 - The national agency check.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false The national agency check. 147.24 Section 147.24 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... reinvestigations. It consists of a review of; (a) Investigative and criminal history files of the FBI, including a...

  19. 32 CFR 147.24 - The national agency check.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false The national agency check. 147.24 Section 147.24 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... reinvestigations. It consists of a review of; (a) Investigative and criminal history files of the FBI, including a...

  20. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219...

  1. 46 CFR 32.15-35 - Magnetic Compass and Gyrocompass-T/OC.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., MACHINERY, AND HULL REQUIREMENTS Navigation Equipment § 32.15-35 Magnetic Compass and Gyrocompass—T/OC. (a) All tankships in ocean or coastwise service must be fitted with a magnetic compass. (b) All tankships... 46 Shipping 1 2012-10-01 2012-10-01 false Magnetic Compass and Gyrocompass-T/OC. 32.15-35 Section...

  2. 46 CFR 32.15-35 - Magnetic Compass and Gyrocompass-T/OC.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Magnetic Compass and Gyrocompass-T/OC. 32.15-35 Section..., MACHINERY, AND HULL REQUIREMENTS Navigation Equipment § 32.15-35 Magnetic Compass and Gyrocompass—T/OC. (a) All tankships in ocean or coastwise service must be fitted with a magnetic compass. (b) All tankships...

  3. 46 CFR 32.15-35 - Magnetic Compass and Gyrocompass-T/OC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Magnetic Compass and Gyrocompass-T/OC. 32.15-35 Section..., MACHINERY, AND HULL REQUIREMENTS Navigation Equipment § 32.15-35 Magnetic Compass and Gyrocompass—T/OC. (a) All tankships in ocean or coastwise service must be fitted with a magnetic compass. (b) All tankships...

  4. Accelerating Research Productivity in Social Work Programs: Perspectives on NIH's Postdoctoral T32 Research Training Mechanism

    ERIC Educational Resources Information Center

    Matthieu, Monica M.; Bellamy, Jennifer L.; Pena, Juan B.; Scott, Lionel D., Jr.

    2008-01-01

    This article describes the experiences of four social work researchers who pursued an alternative career path immediately following their doctorate in social work by accepting a postdoctoral training fellowship funded by the National Institutes of Health (NIH). As schools of social work look for creative ways to build research capacity, this…

  5. Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop*

    PubMed Central

    Monteil, Arnaud; Chausson, Patrick; Boutourlinsky, Katia; Mezghrani, Alexandre; Huc-Brandt, Sylvaine; Blesneac, Iulia; Bidaud, Isabelle; Lemmers, Céline; Leresche, Nathalie; Lambert, Régis C.; Lory, Philippe

    2015-01-01

    Voltage-dependent calcium channels (Cav) of the T-type family (Cav3.1, Cav3.2, and Cav3.3) are activated by low threshold membrane depolarization and contribute greatly to neuronal network excitability. Enhanced T-type channel activity, especially Cav3.2, contributes to disease states, including absence epilepsy. Interestingly, the intracellular loop connecting domains I and II (I-II loop) of Cav3.2 channels is implicated in the control of both surface expression and channel gating, indicating that this I-II loop plays an important regulatory role in T-type current. Here we describe that co-expression of this I-II loop or its proximal region (Δ1-Cav3.2; Ser423–Pro542) together with recombinant full-length Cav3.2 channel inhibited T-type current without affecting channel expression and membrane incorporation. Similar T-type current inhibition was obtained in NG 108-15 neuroblastoma cells that constitutively express Cav3.2 channels. Of interest, Δ1-Cav3.2 inhibited both Cav3.2 and Cav3.1 but not Cav3.3 currents. Efficacy of Δ1-Cav3.2 to inhibit native T-type channels was assessed in thalamic neurons using viral transduction. We describe that T-type current was significantly inhibited in the ventrobasal neurons that express Cav3.1, whereas in nucleus reticularis thalami neurons that express Cav3.2 and Cav3.3 channels, only the fast inactivating T-type current (Cav3.2 component) was significantly inhibited. Altogether, these data describe a new strategy to differentially inhibit Cav3 isoforms of the T-type calcium channels. PMID:25931121

  6. 32 CFR 32.32 - Real property.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Real property. 32.32 Section 32.32 National... NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 32.32 Real property. Each DoD Component that makes awards under which real property is acquired in whole or in part with Federal funds...

  7. 32 CFR 32.32 - Real property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Real property. 32.32 Section 32.32 National... NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 32.32 Real property. Each DoD Component that makes awards under which real property is acquired in whole or in part with Federal funds...

  8. 32 CFR 32.32 - Real property.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Real property. 32.32 Section 32.32 National... NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 32.32 Real property. Each DoD Component that makes awards under which real property is acquired in whole or in part with Federal funds...

  9. 32 CFR 32.32 - Real property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Real property. 32.32 Section 32.32 National... NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 32.32 Real property. Each DoD Component that makes awards under which real property is acquired in whole or in part with Federal funds...

  10. 32 CFR 32.32 - Real property.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Real property. 32.32 Section 32.32 National... NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 32.32 Real property. Each DoD Component that makes awards under which real property is acquired in whole or in part with Federal funds...

  11. National Training Center Research Issues

    DTIC Science & Technology

    1987-01-01

    ART Research Note 87-06 aNATIONAL TRAINING CENTER RESEARCH ISSUES UThomas J. Rijenour The BDM Corporation I for AR! Field Unit at Presidio of...Monterey, California James H. Banks, Chief DTIC TRAINING RESEARCH LABORATORY-- ELECTE Jack H. Hiller, Director S APR 06 WD D U. S. Army Research Institute...for the Behavioral and Social Sciences January 1987 Anoo ,d 𔃺, a b1c ’ete s@ cGst’butc n jlh, T@d 87 % P= U. S. ARMY RESEARCH INSTITUTE Im FOR THE

  12. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Early termination of research support....123 Early termination of research support: Evaluation of applications and proposals. (a) The... finds an institution has materially failed to comply with the terms of this policy. (b) In making...

  13. 77 FR 76297 - National Institute of Dental & Craniofacial Research; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Dental..., Bethesda, MD 20892, 301-594-0652, [email protected] . Name of Committee: National Institute of Dental... of Dental & Craniofacial Research, National Institutes of Health, 45 Center Dr. Room 4AN 32J...

  14. Aberrant activity of NKL homeobox gene NKX3-2 in a T-ALL subset

    PubMed Central

    Meyer, Corinna; Kaufmann, Maren; Zaborski, Margarete; MacLeod, Roderick A. F.; Drexler, Hans G.

    2018-01-01

    T-cell acute lymphoblastic leukemia (T-ALL) is a hematopoietic malignancy originating from T-cell progenitors in which differentiation is blocked at early stages. Physiological expression of specific NKL homeobox genes obeys a hematopoietic NKL-code implicated in the process of lymphopoiesis while in differentiated T-cells these genes are silenced. We propose that this developmental expression pattern underlies the observation that NKL homeobox genes are the most ubiquitous group of transcription factors deregulated in T-ALL, including TLX1, TLX3, NKX2-5 and NKX3-1. Here, we describe a novel member of the NKL homeobox gene subclass, NKX3-2 (BAPX1), which is aberrantly activated in 18% of pediatric T-ALL patients analyzed while being normally expressed in developing spleen. Identification of NKX3-2 expression in T-ALL cell line CCRF-CEM qualified these cells to model its deregulation and function in a leukemic context. Genomic and chromosomal analyses demonstrated normal configuration of the NKX3-2 locus at chromosome 4p15, thus excluding cytogenetic dysregulation. Comparative expression profiling analysis of NKX3-2 patient data revealed deregulated activity of BMP- and MAPK-signalling. These candidate pathways were experimentally confirmed to mediate aberrant NKX3-2 expression. We also show that homeobox gene SIX6, plus MIR17HG and GATA3 are downstream targets of NKX3-2 and plausibly contribute to the pathogenesis of this malignancy by suppressing T-cell differentiation. Finally, NKL homeobox gene NKX2-5 was activated by NKX3-2 in CCRF-CEM and by FOXG1 in PEER, representing mutually inhibitory activators of this translocated oncogene. Together, our findings reveal a novel oncogenic NKL homeobox gene subclass member which is aberrantly expressed in a large subset of T-ALL patients and participates in a deregulated gene network likely to arise in developing spleen. PMID:29746601

  15. Aberrant activity of NKL homeobox gene NKX3-2 in a T-ALL subset.

    PubMed

    Nagel, Stefan; Meyer, Corinna; Kaufmann, Maren; Zaborski, Margarete; MacLeod, Roderick A F; Drexler, Hans G

    2018-01-01

    T-cell acute lymphoblastic leukemia (T-ALL) is a hematopoietic malignancy originating from T-cell progenitors in which differentiation is blocked at early stages. Physiological expression of specific NKL homeobox genes obeys a hematopoietic NKL-code implicated in the process of lymphopoiesis while in differentiated T-cells these genes are silenced. We propose that this developmental expression pattern underlies the observation that NKL homeobox genes are the most ubiquitous group of transcription factors deregulated in T-ALL, including TLX1, TLX3, NKX2-5 and NKX3-1. Here, we describe a novel member of the NKL homeobox gene subclass, NKX3-2 (BAPX1), which is aberrantly activated in 18% of pediatric T-ALL patients analyzed while being normally expressed in developing spleen. Identification of NKX3-2 expression in T-ALL cell line CCRF-CEM qualified these cells to model its deregulation and function in a leukemic context. Genomic and chromosomal analyses demonstrated normal configuration of the NKX3-2 locus at chromosome 4p15, thus excluding cytogenetic dysregulation. Comparative expression profiling analysis of NKX3-2 patient data revealed deregulated activity of BMP- and MAPK-signalling. These candidate pathways were experimentally confirmed to mediate aberrant NKX3-2 expression. We also show that homeobox gene SIX6, plus MIR17HG and GATA3 are downstream targets of NKX3-2 and plausibly contribute to the pathogenesis of this malignancy by suppressing T-cell differentiation. Finally, NKL homeobox gene NKX2-5 was activated by NKX3-2 in CCRF-CEM and by FOXG1 in PEER, representing mutually inhibitory activators of this translocated oncogene. Together, our findings reveal a novel oncogenic NKL homeobox gene subclass member which is aberrantly expressed in a large subset of T-ALL patients and participates in a deregulated gene network likely to arise in developing spleen.

  16. 32 CFR 37.545 - May I accept costs of prior research as cost sharing?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false May I accept costs of prior research as cost... DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Cost Sharing § 37.545 May I accept costs of prior research as cost sharing? No, you may not count any...

  17. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. B... 32 National Defense 2 2010-07-01 2010-07-01 false Procedures for Historical Researchers...

  18. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. B... 32 National Defense 2 2011-07-01 2011-07-01 false Procedures for Historical Researchers...

  19. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. B... 32 National Defense 2 2014-07-01 2014-07-01 false Procedures for Historical Researchers...

  20. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. B... 32 National Defense 2 2013-07-01 2013-07-01 false Procedures for Historical Researchers...

  1. 32 CFR Appendix B to Part 197 - Procedures for Historical Researchers Permanently Assigned Within the Executive Branch Working on...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. B... 32 National Defense 2 2012-07-01 2012-07-01 false Procedures for Historical Researchers...

  2. 32 CFR Appendix A to Part 555 - Director of Defense Research and Engineering

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Director of Defense Research and Engineering A... Engineering June 14, 1974. Memorandum for Assistant Secretaries of the Military Departments (R&D) Subject: Non... Engineering Assistant Secretary of Defense (Comptroller). Subject: Non-Defense Work in DOD Laboratories and R...

  3. 32 CFR Appendix A to Part 555 - Director of Defense Research and Engineering

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Director of Defense Research and Engineering A... Engineering June 14, 1974. Memorandum for Assistant Secretaries of the Military Departments (R&D) Subject: Non... Engineering Assistant Secretary of Defense (Comptroller). Subject: Non-Defense Work in DOD Laboratories and R...

  4. 32 CFR Appendix A to Part 555 - Director of Defense Research and Engineering

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Director of Defense Research and Engineering A... Engineering June 14, 1974. Memorandum for Assistant Secretaries of the Military Departments (R&D) Subject: Non... Engineering Assistant Secretary of Defense (Comptroller). Subject: Non-Defense Work in DOD Laboratories and R...

  5. 32 CFR Appendix A to Part 555 - Director of Defense Research and Engineering

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Director of Defense Research and Engineering A... Engineering June 14, 1974. Memorandum for Assistant Secretaries of the Military Departments (R&D) Subject: Non... Engineering Assistant Secretary of Defense (Comptroller). Subject: Non-Defense Work in DOD Laboratories and R...

  6. 32 CFR Appendix A to Part 555 - Director of Defense Research and Engineering

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Director of Defense Research and Engineering A... Engineering June 14, 1974. Memorandum for Assistant Secretaries of the Military Departments (R&D) Subject: Non... Engineering Assistant Secretary of Defense (Comptroller). Subject: Non-Defense Work in DOD Laboratories and R...

  7. 32 CFR 553.7 - Design and layout of Army national cemeteries.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Design and layout of Army national cemeteries... RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.7 Design and layout of Army national cemeteries. (a) General cemetery layout plans, landscape planting plans and gravesite layout plans for Army...

  8. 32 CFR 553.7 - Design and layout of Army national cemeteries.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Design and layout of Army national cemeteries... RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.7 Design and layout of Army national cemeteries. (a) General cemetery layout plans, landscape planting plans and gravesite layout plans for Army...

  9. 32 CFR 553.7 - Design and layout of Army national cemeteries.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Design and layout of Army national cemeteries... RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.7 Design and layout of Army national cemeteries. (a) General cemetery layout plans, landscape planting plans and gravesite layout plans for Army...

  10. 32 CFR 553.7 - Design and layout of Army national cemeteries.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Design and layout of Army national cemeteries... RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.7 Design and layout of Army national cemeteries. (a) General cemetery layout plans, landscape planting plans and gravesite layout plans for Army...

  11. 32 CFR 553.7 - Design and layout of Army national cemeteries.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Design and layout of Army national cemeteries... RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.7 Design and layout of Army national cemeteries. (a) General cemetery layout plans, landscape planting plans and gravesite layout plans for Army...

  12. 32 CFR 219.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 219.120 Section 219.120 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED...

  13. 32 CFR 644.409 - Procedures for Interchange of National Forest Lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Procedures for Interchange of National Forest... Interests § 644.409 Procedures for Interchange of National Forest Lands. (a) General. The interchange of national forest lands is accomplished in three steps: first, agreement must be reached between the two...

  14. 32 CFR 637.14 - Use of National Crime Information Center (NCIC).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Use of National Crime Information Center (NCIC). 637.14 Section 637.14 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... Use of National Crime Information Center (NCIC). Provost marshals will make maximum use of NCIC...

  15. TR32DB - Management of Research Data in a Collaborative, Interdisciplinary Research Project

    NASA Astrophysics Data System (ADS)

    Curdt, Constanze; Hoffmeister, Dirk; Waldhoff, Guido; Lang, Ulrich; Bareth, Georg

    2015-04-01

    The management of research data in a well-structured and documented manner is essential in the context of collaborative, interdisciplinary research environments (e.g. across various institutions). Consequently, set-up and use of a research data management (RDM) system like a data repository or project database is necessary. These systems should accompany and support scientists during the entire research life cycle (e.g. data collection, documentation, storage, archiving, sharing, publishing) and operate cross-disciplinary in interdisciplinary research projects. Challenges and problems of RDM are well-know. Consequently, the set-up of a user-friendly, well-documented, sustainable RDM system is essential, as well as user support and further assistance. In the framework of the Transregio Collaborative Research Centre 32 'Patterns in Soil-Vegetation-Atmosphere Systems: Monitoring, Modelling, and Data Assimilation' (CRC/TR32), funded by the German Research Foundation (DFG), a RDM system was self-designed and implemented. The CRC/TR32 project database (TR32DB, www.tr32db.de) is operating online since early 2008. The TR32DB handles all data, which are created by the involved project participants from several institutions (e.g. Universities of Cologne, Bonn, Aachen, and the Research Centre Jülich) and research fields (e.g. soil and plant sciences, hydrology, geography, geophysics, meteorology, remote sensing). Very heterogeneous research data are considered, which are resulting from field measurement campaigns, meteorological monitoring, remote sensing, laboratory studies and modelling approaches. Furthermore, outcomes like publications, conference contributions, PhD reports and corresponding images are regarded. The TR32DB project database is set-up in cooperation with the Regional Computing Centre of the University of Cologne (RRZK) and also located in this hardware environment. The TR32DB system architecture is composed of three main components: (i) a file-based data

  16. Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32)

    PubMed Central

    2011-01-01

    Background Elevated numbers of regulatory T cells (Tregs) have been implicated in certain cancers. Depletion of Tregs has been shown to increase anti-tumor immunity. Tregs also play a critical role in the suppression of autoimmune responses. The study of Tregs has been hampered by a lack of adequate surface markers. Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated Tregs. However, there is limited information regarding the processing of LRRC32 or the regulatory phenotype and functional activity of Tregs expressing LRRC32. Results Using naturally-occurring freshly isolated Tregs, we demonstrate that low levels of LRRC32 are present intracellularly prior to activation and that freshly isolated LRRC32+ Tregs are distinct from LRRC32- Tregs with respect to the expression of surface CD62L. Using LRRC32 transfectants of HEK cells, we demonstrate that the N-terminus of LRRC32 is cleaved prior to expression of the protein at the cell surface. Furthermore, we demonstrate using a construct containing a deleted putative signal peptide region that the presence of a signal peptide region is critical to cell surface expression of LRRC32. Finally, mixed lymphocyte assays demonstrate that LRRC32+ Tregs are more potent suppressors than LRRC32- Tregs. Conclusions A cleaved signal peptide site in LRRC32 is necessary for surface localization of native LRRC32 following activation of naturally-occurring freshly-isolated regulatory T cells. LRRC32 expression appears to alter the surface expression of activation markers of T cells such as CD62L. LRRC32 surface expression may be useful as a marker that selects for more potent Treg populations. In summary, understanding the processing and expression of LRRC32 may provide insight into the mechanism of action of Tregs and the refinement of immunotherapeutic strategies aimed at targeting these cells. PMID:21615933

  17. 46 CFR 32.53-1 - Application-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... system that uses crude oil washing. (4) An existing product carrier of 20,000 deadweight tons (metric) or... REQUIREMENTS Inert Gas System § 32.53-1 Application—T/ALL. (a) Except as provided in paragraphs (b) and (c) of... tons (metric) or more or combination carrier of 50,000 DWT tons (metric) or more, that has a keel...

  18. 46 CFR 32.53-1 - Application-T/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... system that uses crude oil washing. (4) An existing product carrier of 20,000 deadweight tons (metric) or... REQUIREMENTS Inert Gas System § 32.53-1 Application—T/ALL. (a) Except as provided in paragraphs (b) and (c) of... tons (metric) or more or combination carrier of 50,000 DWT tons (metric) or more, that has a keel...

  19. 46 CFR 32.53-1 - Application-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... system that uses crude oil washing. (4) An existing product carrier of 20,000 deadweight tons (metric) or... REQUIREMENTS Inert Gas System § 32.53-1 Application—T/ALL. (a) Except as provided in paragraphs (b) and (c) of... tons (metric) or more or combination carrier of 50,000 DWT tons (metric) or more, that has a keel...

  20. 46 CFR 32.53-1 - Application-T/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... system that uses crude oil washing. (4) An existing product carrier of 20,000 deadweight tons (metric) or... REQUIREMENTS Inert Gas System § 32.53-1 Application—T/ALL. (a) Except as provided in paragraphs (b) and (c) of... tons (metric) or more or combination carrier of 50,000 DWT tons (metric) or more, that has a keel...

  1. 46 CFR 32.53-1 - Application-T/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... system that uses crude oil washing. (4) An existing product carrier of 20,000 deadweight tons (metric) or... REQUIREMENTS Inert Gas System § 32.53-1 Application—T/ALL. (a) Except as provided in paragraphs (b) and (c) of... tons (metric) or more or combination carrier of 50,000 DWT tons (metric) or more, that has a keel...

  2. 32 CFR 728.25 - Army and Air Force National Guard personnel.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Army and Air Force National Guard personnel. 728... Guard Personnel § 728.25 Army and Air Force National Guard personnel. (a) Medical and dental care. Upon... Care) and AFR 168-6 (Persons Authorized Medical Care) to members of the Army and Air Force National...

  3. 32 CFR 728.25 - Army and Air Force National Guard personnel.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Army and Air Force National Guard personnel. 728... Guard Personnel § 728.25 Army and Air Force National Guard personnel. (a) Medical and dental care. Upon... Care) and AFR 168-6 (Persons Authorized Medical Care) to members of the Army and Air Force National...

  4. 32 CFR 728.25 - Army and Air Force National Guard personnel.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Army and Air Force National Guard personnel. 728... Guard Personnel § 728.25 Army and Air Force National Guard personnel. (a) Medical and dental care. Upon... Care) and AFR 168-6 (Persons Authorized Medical Care) to members of the Army and Air Force National...

  5. 32 CFR 728.25 - Army and Air Force National Guard personnel.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Army and Air Force National Guard personnel. 728... Guard Personnel § 728.25 Army and Air Force National Guard personnel. (a) Medical and dental care. Upon... Care) and AFR 168-6 (Persons Authorized Medical Care) to members of the Army and Air Force National...

  6. 32 CFR 219.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Assuring compliance with this policy-research conducted or supported by any Federal Department or Agency. 219.103 Section 219.103 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF...

  7. 32 CFR 553.22 - Visitors' rules for the Arlington National Cemetery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Visitors' rules for the Arlington National Cemetery. 553.22 Section 553.22 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... authority from the Administrator, General Services Administration, the Secretary of Defense, and the...

  8. 32 CFR 553.15 - Persons eligible for burial in Arlington National Cemetery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Persons eligible for burial in Arlington National Cemetery. 553.15 Section 553.15 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.15 Persons...

  9. CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA.

    PubMed

    Martin, Genevieve E; Pace, Matthew; Thornhill, John P; Phetsouphanh, Chansavath; Meyerowitz, Jodi; Gossez, Morgane; Brown, Helen; Olejniczak, Natalia; Lwanga, Julianne; Ramjee, Gita; Kaleebu, Pontiano; Porter, Kholoud; Willberg, Christian B; Klenerman, Paul; Nwokolo, Nneka; Fox, Julie; Fidler, Sarah; Frater, John

    2018-01-01

    Efforts to both characterize and eradicate the HIV reservoir have been limited by the rarity of latently infected cells and the absence of a specific denoting biomarker. CD32a (FcγRIIa) has been proposed to be a marker for an enriched CD4 T cell HIV reservoir, but this finding remains controversial. Here, we explore the expression of CD32 on CD3 + CD4 + cells in participants from two primary HIV infection studies and identify at least three distinct phenotypes (CD32 low , CD32 + CD14 + , and CD32 high ). Of note, CD4 negative enrichment kits remove the majority of CD4 + CD32 + T cells, potentially skewing subsequent analyses if used. CD32 high CD4 T cells had higher levels of HLA-DR and HIV co-receptor expression than other subsets, compatible with their being more susceptible to infection. Surprisingly, they also expressed high levels of CD20, TCRαβ, IgD, and IgM (but not IgG), markers for both T cells and naïve B cells. Compared with other populations, CD32 low cells had a more differentiated memory phenotype and high levels of immune checkpoint receptors, programmed death receptor-1 (PD-1), Tim-3, and TIGIT. Within all three CD3 + CD4 + CD32 + phenotypes, cells could be identified in infected participants, which contained HIV DNA. CD32 expression on CD4 T cells did not correlate with HIV DNA or cell-associated HIV RNA (both surrogate measures of overall reservoir size) or predict time to rebound viremia following treatment interruption, suggesting that it is not a dominant biomarker for HIV persistence. Our data suggest that while CD32 + T cells can be infected with HIV, CD32 is not a specific marker of the reservoir although it might identify a population of HIV enriched cells in certain situations.

  10. 75 FR 66113 - National Institute of Mental Health; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... Emphasis Panel; NRSA Institutional Research Training (T32). Date: November 17, 2010. Time: 8 a.m. to 5 p.m... Institute of Mental Health Special Emphasis Panel; Novel NeuroAIDS Therapeutics. Date: November 22, 2010... Research Service Awards for Research Training, National Institutes of Health, HHS) Dated: October 20, 2010...

  11. 46 CFR 32.85-1 - Fireproofing of lamp, oil and paint rooms-T/ALL.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Fireproofing of lamp, oil and paint rooms-T/ALL. 32.85-1..., MACHINERY, AND HULL REQUIREMENTS Lamp and Paint Rooms and Similar Compartments on Tankships § 32.85-1 Fireproofing of lamp, oil and paint rooms—T/ALL. Lamp, oil and paint rooms shall be wholly and tightly lined...

  12. 46 CFR 32.85-1 - Fireproofing of lamp, oil and paint rooms-T/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Fireproofing of lamp, oil and paint rooms-T/ALL. 32.85-1..., MACHINERY, AND HULL REQUIREMENTS Lamp and Paint Rooms and Similar Compartments on Tankships § 32.85-1 Fireproofing of lamp, oil and paint rooms—T/ALL. Lamp, oil and paint rooms shall be wholly and tightly lined...

  13. 46 CFR 32.85-1 - Fireproofing of lamp, oil and paint rooms-T/ALL.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Fireproofing of lamp, oil and paint rooms-T/ALL. 32.85-1..., MACHINERY, AND HULL REQUIREMENTS Lamp and Paint Rooms and Similar Compartments on Tankships § 32.85-1 Fireproofing of lamp, oil and paint rooms—T/ALL. Lamp, oil and paint rooms shall be wholly and tightly lined...

  14. 46 CFR 32.85-1 - Fireproofing of lamp, oil and paint rooms-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Fireproofing of lamp, oil and paint rooms-T/ALL. 32.85-1..., MACHINERY, AND HULL REQUIREMENTS Lamp and Paint Rooms and Similar Compartments on Tankships § 32.85-1 Fireproofing of lamp, oil and paint rooms—T/ALL. Lamp, oil and paint rooms shall be wholly and tightly lined...

  15. 46 CFR 32.85-1 - Fireproofing of lamp, oil and paint rooms-T/ALL.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Fireproofing of lamp, oil and paint rooms-T/ALL. 32.85-1..., MACHINERY, AND HULL REQUIREMENTS Lamp and Paint Rooms and Similar Compartments on Tankships § 32.85-1 Fireproofing of lamp, oil and paint rooms—T/ALL. Lamp, oil and paint rooms shall be wholly and tightly lined...

  16. 32 CFR 32.43 - Competition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 32.43 Competition. All... 32 National Defense 1 2010-07-01 2010-07-01 false Competition. 32.43 Section 32.43 National... free competition. The recipient shall be alert to organizational conflicts of interest as well as...

  17. 78 FR 70309 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... Health and Human Development Special Emphasis Panel; T32 Institutional Training Grant Award. Date... Rehabilitation Research; 93.209, Contraception and Infertility Loan Repayment Program, National Institutes of...

  18. 32 CFR 635.32 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false General. 635.32 Section 635.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Army Quarterly Trends and Analysis Report § 635.32 General. (a) This...

  19. 32 CFR 635.32 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false General. 635.32 Section 635.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Army Quarterly Trends and Analysis Report § 635.32 General. (a) This...

  20. 32 CFR 635.32 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true General. 635.32 Section 635.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Army Quarterly Trends and Analysis Report § 635.32 General. (a) This...

  1. 32 CFR 635.32 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true General. 635.32 Section 635.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Army Quarterly Trends and Analysis Report § 635.32 General. (a) This...

  2. 32 CFR 635.32 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true General. 635.32 Section 635.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Army Quarterly Trends and Analysis Report § 635.32 General. (a) This...

  3. 32 CFR 3.2 - Background.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Background. 3.2 Section 3.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE ACQUISITION TRANSACTIONS OTHER THAN CONTRACTS, GRANTS, OR COOPERATIVE AGREEMENTS FOR PROTOTYPE PROJECTS § 3.2 Background. “Other transactions” is the...

  4. The value of research : telling the R&T story

    DOT National Transportation Integrated Search

    2009-07-01

    The Federal Highway Administration (FHWA) plays a leadership role in shaping and executing a National Research and Technology (R&T) program. The agency also acts as a convener; collaborations with State, industry, and academic partners provide the fo...

  5. Functional Study of the P32T ITPA Variant Associated with Drug Sensitivity in Humans

    PubMed Central

    Stepchenkova, Elena I.; Tarakhovskaya, Elena R.; Spitler, Kathryn; Frahm, Christin; Menezes, Miriam R.; Simone, Peter D.; Kolar, Carol; Marky, Luis A.; Borgstahl, Gloria E. O.; Pavlov, Youri I.

    2009-01-01

    Sanitization of the cellular nucleotide pools from mutagenic base analogs is necessary for the accuracy of transcription and replication of genetic material and plays a substantial role in cancer prevention. The undesirable mutagenic, recombinogenic and toxic incorporation of purine base analogs (i.e. ITP, dITP, XTP, dXTP or 6-hydroxyaminopurine (HAP) deoxynucleoside triphosphate) into nucleic acids is prevented by inosine triphosphate pyrophosphatase (ITPA). The ITPA gene is a highly conserved, moderately expressed gene. Defects in ITPA orthologs in model organisms cause severe sensitivity to HAP and chromosome fragmentation. A human polymorphic allele 94C->A encodes for the enzyme with a P32T amino acid change and leads to accumulation of non-hydrolyzed ITP. ITPase activity is not detected in erythrocytes of these patients. The P32T polymorphism has also been associated with adverse sensitivity to purine base analog drugs. We have found that the ITPA-P32T mutant is a dimer in solution, as is wild-type ITPA, and has normal ITPA activity in vitro, but the melting point of ITPA-P32T is 5 degrees C lower than that of wild-type. ITPA-P32T is also fully functional in vivo in model organisms as determined by a HAP mutagenesis assay and its complementation of a bacterial ITPA defect. The amount of ITPA protein detected by western blot is severely diminished in a human fibroblast cell line with the 94C->A change. We propose that the P32T mutation exerts its effect in certain human tissues by cumulative effects of destabilization of transcripts, protein stability and availability. PMID:19631656

  6. 32 CFR 651.32 - Introduction.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Introduction. 651.32 Section 651.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Environmental Assessment § 651.32 Introduction. (a) An EA is intended to facilitate agency planning and...

  7. Conceptual Design of Tail-Research EXperiment (T-REX) on Space Plasma Environment Research Facility

    NASA Astrophysics Data System (ADS)

    Xiao, Qingmei; Wang, Xiaogang; E, Peng; Shen, Chao; Wang, Zhibin; Mao, Aohua; Xiao, Chijie; Ding, Weixing; Ji, Hantao; Ren, Yang

    2016-10-01

    Space Environment Simulation Research Infrastructure (SESRI), a scientific project for a major national facility of fundamental researches, has recently been launched at Harbin Institute of Technology (HIT). The Space Plasma Environment Research Facility (SPERF) for simulation of space plasma environment is one of the components of SESRI. It is designed to investigate fundamental issues in space plasma environment, such as energetic particles transportation and the interaction with waves in magnetosphere, magnetic reconnection at magnetopause and magnetotail, etc. Tail-Research Experiment (T-REX) is part of the SPERF for laboratory studies of space physics relevant to tail reconnection and dipolarization process. T-REX is designed to carry out two kinds of experiments: the tail plasmamoid for magnetic reconnection and magnetohydrodynamic waves excited by high speed plasma jet. In this presentation, the scientific goals and experimental plans for T-REX together with the means applied to generate the plasma with desired parameters are reviewed. Two typical scenarios of T-REX with operations of plasma sources and various magnetic configurations to study specific physical processes in space plasmas will also be presented.

  8. 32 CFR 553.16 - Persons eligible for burial in Soldiers' Home National Cemetery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Persons eligible for burial in Soldiers' Home National Cemetery. 553.16 Section 553.16 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.16 Persons...

  9. 32 CFR 553.17 - Persons ineligible for burial in an Army national cemetery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Persons ineligible for burial in an Army national cemetery. 553.17 Section 553.17 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.17 Persons...

  10. 32 CFR 1630.42 - Class 4-C: Alien or dual national.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Class 4-C: Alien or dual national. 1630.42... CLASSIFICATION RULES § 1630.42 Class 4-C: Alien or dual national. In Class 4-C shall be placed any registrant who... service in the United States. (b) Is an alien and who has departed from the United States prior to being...

  11. 32 CFR 1630.42 - Class 4-C: Alien or dual national.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Class 4-C: Alien or dual national. 1630.42... CLASSIFICATION RULES § 1630.42 Class 4-C: Alien or dual national. In Class 4-C shall be placed any registrant who... service in the United States. (b) Is an alien and who has departed from the United States prior to being...

  12. 32 CFR 1630.42 - Class 4-C: Alien or dual national.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Class 4-C: Alien or dual national. 1630.42... CLASSIFICATION RULES § 1630.42 Class 4-C: Alien or dual national. In Class 4-C shall be placed any registrant who... service in the United States. (b) Is an alien and who has departed from the United States prior to being...

  13. 32 CFR 1630.42 - Class 4-C: Alien or dual national.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Class 4-C: Alien or dual national. 1630.42... CLASSIFICATION RULES § 1630.42 Class 4-C: Alien or dual national. In Class 4-C shall be placed any registrant who... service in the United States. (b) Is an alien and who has departed from the United States prior to being...

  14. 32 CFR 1630.42 - Class 4-C: Alien or dual national.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Class 4-C: Alien or dual national. 1630.42... CLASSIFICATION RULES § 1630.42 Class 4-C: Alien or dual national. In Class 4-C shall be placed any registrant who... service in the United States. (b) Is an alien and who has departed from the United States prior to being...

  15. Assessing the Effect of Title 32 Active Guard and Reserves on Personal Readiness in the Army National Guard

    DTIC Science & Technology

    2016-09-01

    results imply that for units with T32 AGR ratios in the lowest 20%, an increase of one percentage point in T32 AGR exposure increases the unit’s ratio...all units. Given the distribution of T32 AGRs and drilling soldiers as of September 2014, our results imply that a cut of 3,000 T32 AGRs (20...only personal readiness, and do not examine medical readiness, equipment readiness, or other important metrics. For these reasons, our results should

  16. 32 CFR 555.4 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Policy. 555.4 Section 555.4 National Defense... OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND DEVELOPMENT AND TESTS, WORK FOR OTHERS § 555.4 Policy. (a) The policies and procedures covered herein extend and supplement the...

  17. 32 CFR 1901.32 - Requests for expedited processing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Requests for expedited processing. 1901.32 Section 1901.32 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Additional Administrative Matters § 1901.32 Requests...

  18. 32 CFR 1901.32 - Requests for expedited processing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Requests for expedited processing. 1901.32 Section 1901.32 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Additional Administrative Matters § 1901.32 Requests...

  19. 32 CFR 32.52 - Financial reporting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Financial reporting. 32.52 Section 32.52 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.52 Financial...

  20. 32 CFR 32.52 - Financial reporting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Financial reporting. 32.52 Section 32.52 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.52 Financial...

  1. 32 CFR 32.52 - Financial reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Financial reporting. 32.52 Section 32.52 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.52 Financial...

  2. 32 CFR 32.52 - Financial reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Financial reporting. 32.52 Section 32.52 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.52 Financial...

  3. 32 CFR 2004.20 - National Industrial Security Program Operating Manual (NISPOM) [201(a)].

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false National Industrial Security Program Operating Manual (NISPOM) [201(a)]. 2004.20 Section 2004.20 National Defense Other Regulations Relating to National... that surface from industry, Executive Branch departments and agencies, or the NISPPAC. When consensus...

  4. 32 CFR Appendix E to Part 197 - Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes E Appendix E to Part 197 National Defense Department of... THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. E Appendix E to Part 197—Form...

  5. 32 CFR 272.4 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... higher education, other nonprofit research institutions, laboratories of other Federal agencies, and... 32 National Defense 2 2014-07-01 2014-07-01 false Policy. 272.4 Section 272.4 National Defense... AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.4 Policy. It is DoD policy that: (a...

  6. 32 CFR 272.4 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... higher education, other nonprofit research institutions, laboratories of other Federal agencies, and... 32 National Defense 2 2013-07-01 2013-07-01 false Policy. 272.4 Section 272.4 National Defense... AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.4 Policy. It is DoD policy that: (a...

  7. 32 CFR 272.4 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... higher education, other nonprofit research institutions, laboratories of other Federal agencies, and... 32 National Defense 2 2012-07-01 2012-07-01 false Policy. 272.4 Section 272.4 National Defense... AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.4 Policy. It is DoD policy that: (a...

  8. 32 CFR 553.16 - Persons eligible for burial in Soldiers' Home National Cemetery.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Persons eligible for burial in Soldiers' Home National Cemetery. 553.16 Section 553.16 National Defense Department of Defense (Continued) DEPARTMENT OF... eligible for burial in Soldiers' Home National Cemetery. The Board of Commissioners of the US Soldiers' and...

  9. 32 CFR 516.32 - Requests for indemnification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Requests for indemnification. 516.32 Section 516.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Individual Liability § 516.32 Requests for indemnification. (a) Policy...

  10. Accelerating Research Productivity in Social Work Programs: Perspectives on NIH's Postdoctoral T32 Research Training Mechanism.

    PubMed

    Matthieu, Monica M; Bellamy, Jennifer L; Peña, Juan B; Scott, Lionel D

    2008-12-01

    This article describes the experiences of four social work researchers who pursued an alternative career path immediately following their doctorate in social work by accepting a postdoctoral training fellowship funded by the National Institutes of Health (NIH). As schools of social work look for creative ways to build research capacity, this article describes the authors' perspectives regarding the considerations to accept postdocs, key elements in their training programs, lessons learned, and outcomes from training. To provide an overview of the funding mechanism and distribution of funds to institutes and centers relevant to social work, data were obtained from databases that list NIH training grants awarded each year. Study results showed a limited amount of variation in fellows' training plans. The majority of training time was spent building skill in manuscript preparation, grant development, and socialization to the NIH culture. Above all other themes, the desire for advanced research training was a critically important factor in accepting a postdoctoral training position. Finally, the outcomes of training may have a profound effect on professional development, yet the long-term trajectory of postdoctoral fellows in academic positions as compared with people without postdoctoral training in social work programs requires further study.

  11. EPA/OFFICE OF RESEARCH AND DEVELOPMENT'S NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY/WESTERN ECOLOGY DIVISION INTERNET SITE

    EPA Science Inventory

    The Western Ecology Division (WED) is one of four ecological effects divisions of the National Health and Environmental Effects Research Laboratory. The four divisions are distributed bio-geographically. WED's mission is 1) to provide EPA with national scientific leadership for t...

  12. 32 CFR 32.48 - Contract provisions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Contract provisions. 32.48 Section 32.48 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... provision to the effect that the recipient, the Department of Defense, the Comptroller General of the United...

  13. 32 CFR 32.48 - Contract provisions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Contract provisions. 32.48 Section 32.48 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... provision to the effect that the recipient, the Department of Defense, the Comptroller General of the United...

  14. 32 CFR 32.48 - Contract provisions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Contract provisions. 32.48 Section 32.48 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... provision to the effect that the recipient, the Department of Defense, the Comptroller General of the United...

  15. 32 CFR 32.48 - Contract provisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Contract provisions. 32.48 Section 32.48 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... provision to the effect that the recipient, the Department of Defense, the Comptroller General of the United...

  16. 32 CFR 32.36 - Intangible property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Intangible property. 32.36 Section 32.36 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., including Governmentwide regulations issued by the Department of Commerce at 37 CFR part 401, “Rights to...

  17. 32 CFR 32.36 - Intangible property.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Intangible property. 32.36 Section 32.36 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., including Governmentwide regulations issued by the Department of Commerce at 37 CFR part 401, “Rights to...

  18. 32 CFR 32.36 - Intangible property.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Intangible property. 32.36 Section 32.36 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., including Governmentwide regulations issued by the Department of Commerce at 37 CFR part 401, “Rights to...

  19. 32 CFR 32.36 - Intangible property.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Intangible property. 32.36 Section 32.36 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., including Governmentwide regulations issued by the Department of Commerce at 37 CFR part 401, “Rights to...

  20. 32 CFR 32.36 - Intangible property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Intangible property. 32.36 Section 32.36 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., including Governmentwide regulations issued by the Department of Commerce at 37 CFR part 401, “Rights to...

  1. Accelerating Research Productivity in Social Work Programs: Perspectives on NIH's Postdoctoral T32 Research Training Mechanism

    PubMed Central

    Matthieu, Monica M.; Bellamy, Jennifer L.; Peña, Juan B.; Scott, Lionel D.

    2014-01-01

    This article describes the experiences of four social work researchers who pursued an alternative career path immediately following their doctorate in social work by accepting a postdoctoral training fellowship funded by the National Institutes of Health (NIH). As schools of social work look for creative ways to build research capacity, this article describes the authors' perspectives regarding the considerations to accept postdocs, key elements in their training programs, lessons learned, and outcomes from training. To provide an overview of the funding mechanism and distribution of funds to institutes and centers relevant to social work, data were obtained from databases that list NIH training grants awarded each year. Study results showed a limited amount of variation in fellows' training plans. The majority of training time was spent building skill in manuscript preparation, grant development, and socialization to the NIH culture. Above all other themes, the desire for advanced research training was a critically important factor in accepting a postdoctoral training position. Finally, the outcomes of training may have a profound effect on professional development, yet the long-term trajectory of postdoctoral fellows in academic positions as compared with people without postdoctoral training in social work programs requires further study. PMID:28316462

  2. 32 CFR 555.7 - Submission of technical proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... research and development laboratories are authorized to submit technical proposals directly to other... 32 National Defense 3 2010-07-01 2010-07-01 true Submission of technical proposals. 555.7 Section... AND NATIONAL CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND...

  3. 32 CFR 32.24 - Program income.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Program income. 32.24 Section 32.24 National... income. (a) DoD Components shall apply the standards set forth in this section in requiring recipient organizations to account for program income related to projects financed in whole or in part with Federal funds...

  4. Impact of t(11;14)(q13;q32) on the outcome of autologous hematopoietic cell transplantation in multiple myeloma.

    PubMed

    Sasaki, Koji; Lu, Gary; Saliba, Rima M; Bashir, Qaiser; Hosing, Chitra; Popat, Uday; Shah, Nina; Parmar, Simrit; Dinh, Yvonne; Ahmed, Sairah; Shpall, Elizabeth J; Kebriaei, Partow; Shah, Jatin J; Orlowski, Robert Z; Champlin, Richard; Qazilbash, Muzaffar H

    2013-08-01

    The t(11;14)(q13;q32) translocation is seen in 15%-20% patients with multiple myeloma (MM). It generally is not associated with worse outcomes. We studied the impact of t(11;14)(q13;q32) on outcome in patients with MM who received high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HCT). Eligible patients underwent high-dose chemotherapy followed by auto-HCT at the M.D. Anderson Cancer Center between February 2000 and August 2010, and had conventional cytogenetic (CC) or fluorescence in situ hybridization (FISH) results available before auto-HCT (n = 993). The cohort was divided into 3 groups of patients: (1) normal (diploid by CC and negative by FISH; n = 869); (2) t(11;14)(q13;q32) by CC or FISH (n = 27); and (3) high-risk (HR) abnormalities by CC or FISH (n = 97). Of the 27 patients with t(11;14)(q13;q32), 18 had isolated t(11;14)(q13;q32) and 9 had concurrent HR abnormalities. The primary objective was to compare outcomes in patients with t(11;14)(q13;q32) and patients with diploid or HR markers detected by CC or FISH studies. The median duration of follow-up in surviving patients was 37 months. The 3-year progression-free survival (PFS) was 47% for the normal group, 27% for the t(11;14)(q13;q32) group, and 13% for the HR group (P < .00001). The 3-year OS was 83% for the normal group, 63% for the t(11;14)(q13;q32) group, and 34% for the HR group (P < .00001). On multivariate analysis, t(11;14)(q13;q32) and HR abnormalities by CC or FISH and relapsed disease at auto-HCT were associated with shorter PFS, whereas t(11;14)(q13;q32) and HR abnormalities by CC or FISH, β2 microglobulin of >3.5, and relapsed disease at the time of auto-HCT were associated with shorter OS. In conclusion, patients with t(11;14)(q13;q32) had worse outcomes than patients with normal CC or FISH studies, but better outcomes than patients with HR markers detected by CC or FISH studies. Copyright © 2013 American Society for Blood and

  5. 32 CFR 516.32 - Requests for indemnification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Requests for indemnification. 516.32 Section 516.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES... allied papers. (c) Supervisory and SJA procedures. The request for indemnification will be submitted...

  6. 32 CFR 516.32 - Requests for indemnification.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Requests for indemnification. 516.32 Section 516.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES... allied papers. (c) Supervisory and SJA procedures. The request for indemnification will be submitted...

  7. 32 CFR 516.32 - Requests for indemnification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Requests for indemnification. 516.32 Section 516.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES... allied papers. (c) Supervisory and SJA procedures. The request for indemnification will be submitted...

  8. 32 CFR 516.32 - Requests for indemnification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Requests for indemnification. 516.32 Section 516.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES... allied papers. (c) Supervisory and SJA procedures. The request for indemnification will be submitted...

  9. High quality draft genome sequence of the moderately halophilic bacterium Pontibacillus yanchengensis Y32(T) and comparison among Pontibacillus genomes.

    PubMed

    Huang, Jing; Qiao, Zi Xu; Tang, Jing Wei; Wang, Gejiao

    2015-01-01

    Pontibacillus yanchengensis Y32(T) is an aerobic, motile, Gram-positive, endospore-forming, and moderately halophilic bacterium isolated from a salt field. In this study, we describe the features of P. yanchengensis strain Y32(T) together with a comparison with other four Pontibacillus genomes. The 4,281,464 bp high-quality-draft genome of strain Y32(T) is arranged into 153 contigs containing 3,965 protein-coding genes and 77 RNA encoding genes. The genome of strain Y32(T) possesses many genes related to its halophilic character, flagellar assembly and chemotaxis to support its survival in a salt-rich environment.

  10. 32 CFR 32.37 - Property trust relationship.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Property trust relationship. 32.37 Section 32.37 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... trust relationship. Real property, equipment, intangible property and debt instruments that are acquired...

  11. 32 CFR 32.3 - Effect on other issuances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Effect on other issuances. 32.3 Section 32.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 32.3 Effect on other issuances. For awards subject...

  12. 32 CFR 728.32 - Application for care.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Application for care. 728.32 Section 728.32 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL MEDICAL AND DENTAL CARE... medical and dental care may be rendered except in emergencies. When required inpatient or outpatient care...

  13. 32 CFR Appendix A to Part 553 - Specifications for Tributes in Arlington National Cemetery

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Specifications for Tributes in Arlington National Cemetery A Appendix A to Part 553 National Defense Department of Defense (Continued) DEPARTMENT OF... Organizations and State Department of Veterans Organizations published annually by the Veterans Administration...

  14. 32 CFR 644.408 - Interchange of national forest and military and civil works lands.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Interchange of national forest and military and... Property and Easement Interests § 644.408 Interchange of national forest and military and civil works lands. 16 U.S.C. 505a, 505b authorizes the Secretary of Agriculture, with respect to national forest lands...

  15. 32 CFR 32.14 - Special award conditions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Special award conditions. 32.14 Section 32.14 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... part, if an applicant or recipient: (1) Has a history of poor performance; (2) Is not financially...

  16. 32 CFR 32.14 - Special award conditions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Special award conditions. 32.14 Section 32.14 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... part, if an applicant or recipient: (1) Has a history of poor performance; (2) Is not financially...

  17. 32 CFR 32.14 - Special award conditions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Special award conditions. 32.14 Section 32.14 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... part, if an applicant or recipient: (1) Has a history of poor performance; (2) Is not financially...

  18. 32 CFR 32.14 - Special award conditions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Special award conditions. 32.14 Section 32.14 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... part, if an applicant or recipient: (1) Has a history of poor performance; (2) Is not financially...

  19. 32 CFR 32.14 - Special award conditions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Special award conditions. 32.14 Section 32.14 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... part, if an applicant or recipient: (1) Has a history of poor performance; (2) Is not financially...

  20. 32 CFR 32.26 - Non-Federal audits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Non-Federal audits. 32.26 Section 32.26 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS...

  1. 32 CFR 651.44 - Incomplete information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... approaches or research methods generally accepted in the scientific community. ... 32 National Defense 4 2011-07-01 2011-07-01 false Incomplete information. 651.44 Section 651.44 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY...

  2. 32 CFR 651.44 - Incomplete information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... approaches or research methods generally accepted in the scientific community. ... 32 National Defense 4 2010-07-01 2010-07-01 true Incomplete information. 651.44 Section 651.44 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY...

  3. 32 CFR 219.124 - Conditions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Conditions. 219.124 Section 219.124 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS... research projects the department or agency head may impose additional conditions prior to or at the time of...

  4. 32 CFR 1900.32 - Procedures for information concerning other persons.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Procedures for information concerning other persons. 1900.32 Section 1900.32 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC ACCESS TO CIA RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Additional...

  5. 32 CFR 1900.32 - Procedures for information concerning other persons.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Procedures for information concerning other persons. 1900.32 Section 1900.32 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC ACCESS TO CIA RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Additional...

  6. 32 CFR 197.3 - Definition.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Definition. 197.3 Section 197.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) § 197.3 Definition. Historical...

  7. 32 CFR 197.3 - Definition.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Definition. 197.3 Section 197.3 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) § 197.3 Definition. Historical...

  8. Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.

    PubMed

    Bourinet, Emmanuel; Alloui, Abdelkrim; Monteil, Arnaud; Barrère, Christian; Couette, Brigitte; Poirot, Olivier; Pages, Anne; McRory, John; Snutch, Terrance P; Eschalier, Alain; Nargeot, Joël

    2005-01-26

    Analgesic therapies are still limited and sometimes poorly effective, therefore finding new targets for the development of innovative drugs is urgently needed. In order to validate the potential utility of blocking T-type calcium channels to reduce nociception, we explored the effects of intrathecally administered oligodeoxynucleotide antisenses, specific to the recently identified T-type calcium channel family (CaV3.1, CaV3.2, and CaV3.3), on reactions to noxious stimuli in healthy and mononeuropathic rats. Our results demonstrate that the antisense targeting CaV3.2 induced a knockdown of the CaV3.2 mRNA and protein expression as well as a large reduction of 'CaV3.2-like' T-type currents in nociceptive dorsal root ganglion neurons. Concomitantly, the antisense treatment resulted in major antinociceptive, anti-hyperalgesic, and anti-allodynic effects, suggesting that CaV3.2 plays a major pronociceptive role in acute and chronic pain states. Taken together, the results provide direct evidence linking CaV3.2 T-type channels to pain perception and suggest that CaV3.2 may offer a specific molecular target for the treatment of pain.

  9. 32 CFR 32.50 - Purpose of reports and records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Purpose of reports and records. 32.50 Section 32.50 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.50 Purpose of...

  10. 32 CFR 32.50 - Purpose of reports and records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Purpose of reports and records. 32.50 Section 32.50 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.50 Purpose of...

  11. 32 CFR 32.50 - Purpose of reports and records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Purpose of reports and records. 32.50 Section 32.50 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.50 Purpose of...

  12. 32 CFR 32.50 - Purpose of reports and records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Purpose of reports and records. 32.50 Section 32.50 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.50 Purpose of...

  13. 32 CFR 32.50 - Purpose of reports and records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Purpose of reports and records. 32.50 Section 32.50 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.50 Purpose of...

  14. 32 CFR 229.12 - Relationship to section 106 of the National Historic Preservation Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Relationship to section 106 of the National Historic Preservation Act. 229.12 Section 229.12 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 229.12 Relationship to section...

  15. 32 CFR 32.23 - Cost sharing or matching.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Cost sharing or matching. 32.23 Section 32.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... efficient accomplishment of project or program objectives. (4) Are allowable under the applicable cost...

  16. 32 CFR 32.23 - Cost sharing or matching.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Cost sharing or matching. 32.23 Section 32.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... efficient accomplishment of project or program objectives. (4) Are allowable under the applicable cost...

  17. 32 CFR 32.23 - Cost sharing or matching.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Cost sharing or matching. 32.23 Section 32.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... efficient accomplishment of project or program objectives. (4) Are allowable under the applicable cost...

  18. 32 CFR 32.23 - Cost sharing or matching.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Cost sharing or matching. 32.23 Section 32.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... efficient accomplishment of project or program objectives. (4) Are allowable under the applicable cost...

  19. 32 CFR 32.23 - Cost sharing or matching.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Cost sharing or matching. 32.23 Section 32.23 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... efficient accomplishment of project or program objectives. (4) Are allowable under the applicable cost...

  20. Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART.

    PubMed

    Coindre, Sixtine; Tchitchek, Nicolas; Alaoui, Lamine; Vaslin, Bruno; Bourgeois, Christine; Goujard, Cecile; Avettand-Fenoel, Veronique; Lecuroux, Camille; Bruhns, Pierre; Le Grand, Roger; Beignon, Anne-Sophie; Lambotte, Olivier; Favier, Benoit

    2018-01-01

    CD32a has been proposed as a specific marker of latently HIV-infected CD4 + T cells. However, CD32a was recently found to be expressed on CD4 + T cells of healthy donors, leading to controversy on the relevance of this marker in HIV persistence. Here, we used mass cytometry to characterize the landscape and variation in the abundance of CD32a + CD4 + T cells during HIV infection. To this end, we analyzed CD32a + CD4 + T cells in primary HIV infection before and after effective combination antiretroviral therapy (cART) and in healthy donors. We found that CD32a + CD4 + T cells include heterogeneous subsets that are differentially affected by HIV infection. Our analysis revealed that naive ( N ), central memory ( CM ), and effector/memory ( Eff/Mem ) CD32a + CD4 + T-cell clusters that co-express LILRA2- and CD64-activating receptors were more abundant in primary HIV infection and cART stages. Conversely, LILRA2 - CD32a + CD4 + T-cell clusters of either the T N , T CM , or T Eff/Mem phenotype were more abundant in healthy individuals. Finally, an activated CD32a + CD4 + T Eff/Mem cell cluster co-expressing LILRA2, CD57, and NKG2C was more abundant in all HIV stages, particularly during primary HIV infection. Overall, our data show that multiple abundance modifications of CD32a + CD4 + T-cell subsets occur in the early phase of HIV infection, and some of which are conserved after effective cART. Our study brings a better comprehension of the relationship between CD32a expression and CD4 + T cells during HIV infection.

  1. China’s S&T Emergence: A Proposal for U.S. DOD-China Collaboration in Fundamental Research

    DTIC Science & Technology

    2008-03-01

    U.S. National Science Foundation points out the rise of S&T capability in Asia.3 Within Asia, China is rapidly becoming a major player in S&T...3 National Science Foundation , Division of Science Resources Statistics, “Asia’s Rising Science and Technology Strength: Comparative...example, the National Science Foundation awarded the University of California Santa Barbara (UCSB) a $1.5 million grant to establish a research and

  2. 7 CFR 1206.32 - Term of office.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Term of office. 1206.32 Section 1206.32 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... INFORMATION Mango Promotion, Research, and Information Order Definitions National Mango Promotion Board § 1206...

  3. 32 CFR 197.4 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 197.4 Section 197.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) § 197.4 Policy. It is DoD policy...

  4. 32 CFR 197.4 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Policy. 197.4 Section 197.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) § 197.4 Policy. It is DoD policy...

  5. 32 CFR 197.4 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Policy. 197.4 Section 197.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) § 197.4 Policy. It is DoD policy...

  6. 32 CFR 197.4 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Policy. 197.4 Section 197.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) § 197.4 Policy. It is DoD policy...

  7. 32 CFR 197.4 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Policy. 197.4 Section 197.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) § 197.4 Policy. It is DoD policy...

  8. 32 CFR 806b.10 - How to collect personal information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false How to collect personal information. 806b.10 Section 806b.10 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE... parties when: (a) You must verify information. (b) You want opinions or evaluations. (c) You can't contact...

  9. 32 CFR 806b.10 - How to collect personal information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false How to collect personal information. 806b.10 Section 806b.10 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE... parties when: (a) You must verify information. (b) You want opinions or evaluations. (c) You can't contact...

  10. Natural Hazards and Research Needs in Coastal and Ocean Engineering, Summary and Recommendations to the National Science Foundation and the Office of Naval Research,

    DTIC Science & Technology

    1984-11-01

    1,746 N. RAL HAZARDS AND RESEARCH NEEDS IN COASTAL AND OCEAN I ENEERING SUMMA..W NATIONAL SCIENCE FOUNDATION WA ;NG ON OC 1NAVE F AL NOV 84 FG02 N N...and Research Needs in Coastal and Ocean Engineering Summary and Recommendations to the National Science Foundation and the Office of Naval Research A T...Recommendations to the National Science Foundation and the Office of Naval Research by the Ad Hoc Committee for the Civil and Environmental Engineering

  11. 32 CFR 161.11 - Benefits for National Guard and Reserve Members of the Uniformed Services.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Benefits for National Guard and Reserve Members of the Uniformed Services. 161.11 Section 161.11 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY IDENTIFICATION (ID) CARDS FOR MEMBERS OF THE UNIFORMED SERVICES, THEIR...

  12. 32 CFR 256.6 - Runway classification by aircraft type.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Runway classification by aircraft type. 256.6... type. Class A runways S-2, VC-6, C-1, C-2, TC-4C, U-10, U-11, LU-16, TU-16, HU-16, C-7, C-8, C-12, C-47...-130, A-7, A-38, AV-8, P-2, P-3, T-29, T-33, T-37, T-39, T-1, HC-130B, C-131, C-140, C-5A, KC-97, F-9...

  13. 32 CFR 256.6 - Runway classification by aircraft type.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Runway classification by aircraft type. 256.6... type. Class A runways S-2, VC-6, C-1, C-2, TC-4C, U-10, U-11, LU-16, TU-16, HU-16, C-7, C-8, C-12, C-47...-130, A-7, A-38, AV-8, P-2, P-3, T-29, T-33, T-37, T-39, T-1, HC-130B, C-131, C-140, C-5A, KC-97, F-9...

  14. 32 CFR 32.52 - Financial reporting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Financial reporting. 32.52 Section 32.52..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports and Records § 32.52 Financial reporting. (a) The following forms or such other forms as may be approved by OMB are authorized for...

  15. 50 CFR 32.5 - What are the requirements for sportfishing on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false What are the requirements for sportfishing on areas of the National Wildlife Refuge System? 32.5 Section 32.5 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE...

  16. 50 CFR 32.5 - What are the requirements for sportfishing on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false What are the requirements for sportfishing on areas of the National Wildlife Refuge System? 32.5 Section 32.5 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE...

  17. 50 CFR 32.5 - What are the requirements for sportfishing on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false What are the requirements for sportfishing on areas of the National Wildlife Refuge System? 32.5 Section 32.5 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE...

  18. 50 CFR 32.5 - What are the requirements for sportfishing on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are the requirements for sportfishing on areas of the National Wildlife Refuge System? 32.5 Section 32.5 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE...

  19. 50 CFR 32.5 - What are the requirements for sportfishing on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What are the requirements for sportfishing on areas of the National Wildlife Refuge System? 32.5 Section 32.5 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE...

  20. DARPP-32: from neurotransmission to cancer

    PubMed Central

    Belkhiri, Abbes; Zhu, Shoumin; El-Rifai, Wael

    2016-01-01

    Dopamine and cAMP-regulated phosphoprotein Mr 32,000 (DARPP-32), also known as phosphoprotein phosphatase-1 regulatory subunit 1B (PPP1R1B), was initially discovered as a substrate of dopamine-activated protein kinase A (PKA) in the neostriatum in the brain. While phosphorylation at Thr-34 by PKA converts DARPP-32 into a potent inhibitor of protein phosphatase 1 (PP1), phosphorylation at Thr-75 transforms DARPP-32 into an inhibitor of PKA. Through regulation of DARPP-32 phosphorylation and modulation of protein phosphatase and kinase activities, DARPP-32 plays a critical role in mediating the biochemical, electrophysiological, and behavioral effects controlled by dopamine and other neurotransmitters in response to drugs of abuse and psychostimulants. Altered expression of DARPP-32 and its truncated isoform (t-DARPP), specifically in the prefrontal cortex, has been associated with schizophrenia and bipolar disorder. Moreover, cleavage of DARPP-32 by calpain has been implicated in Alzheimer's disease. Amplification of the genomic locus of DARPP-32 at 17q12 has been described in several cancers. DARPP-32 and t-DARPP are frequently overexpressed at the mRNA and protein levels in adenocarcinomas of the breast, prostate, colon, and stomach. Several studies demonstrated the pro-survival, pro-invasion, and pro-angiogenic functions of DARPP-32 in cancer. Overexpression of DARPP-32 and t-DARPP also promotes chemotherapeutic drug resistance and cell proliferation in gastric and breast cancers through regulation of pro-oncogenic signal transduction pathways. The expansion of DARPP-32 research from neurotransmission to cancer underscores the broad scope and implication of this protein in disparate human diseases. PMID:26872373

  1. 50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...

  2. 50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...

  3. 50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...

  4. 50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...

  5. 50 CFR 32.2 - What are the requirements for hunting on areas of the National Wildlife Refuge System?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false What are the requirements for hunting on areas of the National Wildlife Refuge System? 32.2 Section 32.2 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM...

  6. Increased yield of PCR products by addition of T4 gene 32 protein to the SMART PCR cDNA synthesis system.

    PubMed

    Villalva, C; Touriol, C; Seurat, P; Trempat, P; Delsol, G; Brousset, P

    2001-07-01

    Under certain conditions, T4 gene 32 protein is known to increase the efficiency of different enzymes, such as Taq DNA polymerase, reverse transcriptase, and telomerase. In this study, we compared the efficiency of the SMART PCR cDNA synthesis kit with and without the T4 gene 32 protein. The use of this cDNA synthesis procedure, in combination with T4 gene 32 protein, increases the yield of RT-PCR products from approximately 90% to 150%. This effect is even observed for long mRNA templates and low concentrations of total RNA (25 ng). Therefore, we suggest the addition of T4 gene 32 protein in the RT-PCR mixture to increase the efficiency of cDNA synthesis, particularly in cases when low amounts of tissue are used.

  7. 32 CFR 634.32 - Traffic violation reports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Traffic violation reports. 634.32 Section 634.32... CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.32 Traffic violation reports. (a) Most traffic violations occurring on DOD installations (within the UNITED STATES or its...

  8. 32 CFR 634.32 - Traffic violation reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Traffic violation reports. 634.32 Section 634.32... CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.32 Traffic violation reports. (a) Most traffic violations occurring on DOD installations (within the UNITED STATES or its...

  9. The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable.

    PubMed

    Knopman, David S; Haeberlein, Samantha Budd; Carrillo, Maria C; Hendrix, James A; Kerchner, Geoff; Margolin, Richard; Maruff, Paul; Miller, David S; Tong, Gary; Tome, Maria B; Murray, Melissa E; Nelson, Peter T; Sano, Mary; Mattsson, Niklas; Sultzer, David L; Montine, Thomas J; Jack, Clifford R; Kolb, Hartmuth; Petersen, Ronald C; Vemuri, Prashanthi; Canniere, Megan Zoschg; Schneider, Julie A; Resnick, Susan M; Romano, Gary; van Harten, Argonde Corien; Wolk, David A; Bain, Lisa J; Siemers, Eric

    2018-04-01

    The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the "A, T, N System" (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed. Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

  10. 32 CFR 32.53 - Retention and access requirements for records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Retention and access requirements for records. 32.53 Section 32.53 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD... OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports...

  11. 32 CFR 32.53 - Retention and access requirements for records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Retention and access requirements for records. 32.53 Section 32.53 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD... OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Reports...

  12. Resident Research Experience and Career Path Association: A National Survey of Recent Otolaryngology Graduates.

    PubMed

    Zahtz, Gerald; Vambutas, Andrea; Hussey, Heather M; Rosen, Lisa

    2014-07-01

    To determine whether the research rotation experience affects the career path of otolaryngology residents. Two web-based surveys were disseminated by the AAO-HNS; one to current and former resident trainees and the other to current residency program directors. A web-based survey was disseminated to all AAO-HNS members classified as otolaryngology residents or residency graduates within the last 6 years, regarding their research rotation and its potential influence on their career path. A second web-based survey was delivered simultaneously to program directors to evaluate their perception of the need for research in a training program and their role in the rotation. Chi-square tests for independence as well as multivariate analyses were conducted to determine whether aspects of the resident research rotation related to career path. The resident survey was completed by 350 respondents (25% response rate), and 39 program directors completed the second survey (37% response rate). Multiple factors were examined, including federal funding of faculty, mentorship, publications prior to residency, success of research project measured by publication or grant submission, and type of research. Multivariate analyses revealed that factors most predictive of academic career path were intellectual satisfaction and presence of a T32 training grant within the program (P < .05). The composition and quality of the residency research rotation vary across institutions. Factors that enhance stronger intellectual satisfaction and the presence of T32 grant, which demonstrates an institution's commitment to research training, may promote pursuit of a career in academia versus private practice. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

  13. 46 CFR 32.56-25 - Category A machinery spaces: Windows and port lights-T/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Category A machinery spaces: Windows and port lights-T... Laying Date On or After January 1, 1975 § 32.56-25 Category A machinery spaces: Windows and port lights—T..., boundaries of category A machinery spaces and boundaries of cargo pumprooms must not be pierced for windows...

  14. 32 CFR 643.32 - Policy-Endangered species.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ESTATE Policy § 643.32 Policy—Endangered species. The Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), declares the intention of Congress to conserve threatened and endangered species of fish... 32 National Defense 4 2011-07-01 2011-07-01 false Policy-Endangered species. 643.32 Section 643.32...

  15. 32 CFR 643.32 - Policy-Endangered species.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ESTATE Policy § 643.32 Policy—Endangered species. The Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), declares the intention of Congress to conserve threatened and endangered species of fish... 32 National Defense 4 2013-07-01 2013-07-01 false Policy-Endangered species. 643.32 Section 643.32...

  16. 32 CFR 643.32 - Policy-Endangered species.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ESTATE Policy § 643.32 Policy—Endangered species. The Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), declares the intention of Congress to conserve threatened and endangered species of fish... 32 National Defense 4 2012-07-01 2011-07-01 true Policy-Endangered species. 643.32 Section 643.32...

  17. 32 CFR 643.32 - Policy-Endangered species.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ESTATE Policy § 643.32 Policy—Endangered species. The Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), declares the intention of Congress to conserve threatened and endangered species of fish... 32 National Defense 4 2014-07-01 2013-07-01 true Policy-Endangered species. 643.32 Section 643.32...

  18. 32 CFR 643.32 - Policy-Endangered species.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ESTATE Policy § 643.32 Policy—Endangered species. The Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), declares the intention of Congress to conserve threatened and endangered species of fish... 32 National Defense 4 2010-07-01 2010-07-01 true Policy-Endangered species. 643.32 Section 643.32...

  19. About the Frederick National Laboratory for Cancer Research | Frederick National Laboratory for Cancer Research

    Cancer.gov

    The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and currently operated by Leidos Biomedical Research, Inc. The laboratory addresses some of the most urge

  20. 32 CFR 219.112 - Review by institution.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Review by institution. 219.112 Section 219.112 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.112 Review by institution. Research covered by this policy that...

  1. 32 CFR 746.3 - Delegation of authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Delegation of authority. 746.3 Section 746.3 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PROCUREMENT, PROPERTY, PATENTS... Delegation of authority. The Chief of Naval Research is delegated the authority to administer the patent...

  2. 32 CFR 746.3 - Delegation of authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Delegation of authority. 746.3 Section 746.3 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PROCUREMENT, PROPERTY, PATENTS... Delegation of authority. The Chief of Naval Research is delegated the authority to administer the patent...

  3. Enhanced t -3/2 long-time tail for the stress-stress time correlation function

    NASA Astrophysics Data System (ADS)

    Evans, Denis J.

    1980-01-01

    Nonequilibrium molecular dynamics is used to calculate the spectrum of shear viscosity for a Lennard-Jones fluid. The calculated zero-frequency shear viscosity agrees well with experimental argon results for the two state points considered. The low-frequency behavior of shear viscosity is dominated by an ω 1/2 cusp. Analysis of the form of this cusp reveals that the stress-stress time correlation function exhibits a t -3/2 "long-time tail." It is shown that for the state points studied, the amplitude of this long-time tail is between 12 and 150 times larger than what has been predicted theoretically. If the low-frequency results are truly asymptotic, they imply that the cross and potential contributions to the Kubo-Green integrand for shear viscosity exhibit a t -3/2 long-time tail. This result contradicts the established theory of such processes.

  4. Precision Test of the Isobaric Multiplet Mass Equation in the A = 32, T = 2 Quintet

    NASA Astrophysics Data System (ADS)

    Ferrer, R.; Kwiatkowski, A. A.; Bollen, G.; Campbell, C. M.; Folden, C. M., III; Lincoln, D.; Morrissey, D. J.; Pang, G. K.; Prinke, A.; Savory, J.; Schwarz, S.

    2008-10-01

    Masses of the radionuclides ^32,33Si and ^34P and of the stable nuclide ^32S have been measured with the Low Energy Beam and Ion Trap (LEBIT) Penning trap mass spectrometer. Relative mass uncertainties of 3 x 10-8 and better have been achieved. The measured mass value of ^32Si differs from the literature value [1,2] by four standard deviations. The precise mass determination of ^32Si and ^32S have been employed to test the isobaric multiplet mass equation for the A = 32, T= 2 isospin quintet. The experimental results indicate a significant deviation from the quadratic form. This work has been supported by Michigan State University, the NSF under contract number PHY- 0606007, and the DOE under the contract DE-FG02-00ER41144. References: 1. G. Audi, A.H. Wapstra, and C. Thibault, Nucl. Phys. A729 (2003) 337 2. A. Paul, S. R"ottger, A. Zimbal, and U. Keyser, Hyperfine Interact. 132 (2001) 189

  5. National Practice Patterns for Clinical T1N0 Nasopharyngeal Cancer in the Elderly: A National Cancer Data Base Analysis.

    PubMed

    Post, Carl M; Lin, Chi; Adeberg, Sebastian; Gupta, Mrigank; Zhen, Weining; Verma, Vivek

    2018-03-01

    The standard of care for T1N0 nasopharyngeal cancer (NPC) is definitive radiation therapy (RT). However, practice patterns in the elderly may not necessarily follow national guidelines. Herein, we investigated national practice patterns for T1N0 NPC. The National Cancer Data Base (NCDB) was queried for clinical T1N0 primary NPC cases (2004-2013) in patients ≥70 years old. Patient, tumor, and treatment parameters were extracted. Kaplan-Meier analysis was used to compare overall survival (OS) between patients receiving RT versus those under observation. Logistic regression was used to examine variables associated with receipt of RT. Cox proportional hazards modeling determined variables associated with OS. Landmark analysis of patients surviving 1 year or more was performed to assess survival differences between groups. In total, data of 147 patients were analyzed. RT was delivered to 89 patients (61%), whereas 58 (39%) patients underwent observation. On multivariable analysis, older patients were less likely to receive RT (p=0.003), but there were no differences between groups in terms of Charlson-Deyo comorbidity index. Median and 5-year OS in patients receiving RT versus those under observation were 71 and 33 months, and 59% and 48% (p=0.011), respectively. For patients surviving 1 year or more (n=96), there was a strong trend showing that receipt of RT was associated with better median and 5-year OS. This National Data Base analysis shows that observation is relatively common for T1N0 NPC in the elderly, but is associated with poorer survival. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  6. T1-weighted brain imaging with a 32-channel coil at 3T using TurboFLASH BLADE compared with standard cartesian k-space sampling.

    PubMed

    Attenberger, Ulrike I; Runge, Val M; Williams, Kenneth D; Stemmer, Alto; Michaely, Henrik J; Schoenberg, Stefan O; Reiser, Maximilian F; Wintersperger, Bernd J

    2009-03-01

    Motion artifacts often markedly degrade image quality in clinical scans. The BLADE technique offers an alternative k-space sampling scheme reducing the effect of patient related motion on image quality. The purpose of this study is the comparison of imaging artifacts, signal-to-noise (SNR), and contrast-to-noise ratio (CNR) of a new turboFLASH BLADE k-space trajectory with the standard Cartesian k-space sampling for brain imaging, using a 32-channel coil at 3T. The results from 32 patients included after informed consent are reported. This study was performed with a 32-channel head coil on a 3T scanner. Sagittal and axial T1-weighted FLASH sequences (TR/TE 250/2.46 milliseconds, flip angle 70-degree), acquired with Cartesian k-space sampling and T1-weighted turboFLASH sequences (TR/TE/TIsag/TIax 3200/2.77/1144/1056 milliseconds, flip angle 20-degree), using PROPELLER (BLADE) k-space trajectory, were compared. SNR and CNR were evaluated using a paired student t test. The frequency of motion artifacts was assessed in a blinded read. To analyze the differences between both techniques a McNemar test was performed. A P value <0.05 was considered statistically significant. From the blinded read, the overall preference in terms of diagnostic image quality was statistically significant in favor of the BLADE turboFLASH data sets, compared with standard FLASH for both sagittal (P < 0.0001) and axial (P < 0.0001) planes. The frequency of motion artifacts from the scalp was higher for standard FLASH sequences than for BLADE sequences on both axial (47%, P < 0.0003) and sagittal (69%, P < 0.0001) planes. BLADE was preferred in 100% (sagittal plane) and 80% (axial plane) of in-patient data sets and in 68% (sagittal plane) and 73% (axial plane) of out-patient data sets.The BLADE T1 scan did have lower SNRmean (BLADEax 179 +/- 98, Cartesianax 475 +/- 145, BLADEsag 171 +/- 51, and Cartesiansag 697 +/- 129) with P values indicating accordingly a statistically significant difference

  7. 32 CFR Appendix B to Part 22 - Suggested Award Provisions for National Policy Requirements That Often Apply

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Suggested Award Provisions for National Policy Requirements That Often Apply B Appendix B to Part 22 National Defense Department of Defense OFFICE OF THE... Pt. 22, App. B Appendix B to Part 22—Suggested Award Provisions for National Policy Requirements That...

  8. 32 CFR Appendix B to Part 22 - Suggested Award Provisions for National Policy Requirements That Often Apply

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Suggested Award Provisions for National Policy Requirements That Often Apply B Appendix B to Part 22 National Defense Department of Defense OFFICE OF THE... Pt. 22, App. B Appendix B to Part 22—Suggested Award Provisions for National Policy Requirements That...

  9. 32 CFR 32.37 - Property trust relationship.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Property trust relationship. 32.37 Section 32.37... trust relationship. Real property, equipment, intangible property and debt instruments that are acquired or improved with Federal funds shall be held in trust by the recipient as trustee for the...

  10. 32 CFR 32.15 - Metric system of measurement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Metric system of measurement. 32.15 Section 32..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 32.15 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce, and for...

  11. 32 CFR 32.15 - Metric system of measurement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Metric system of measurement. 32.15 Section 32..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 32.15 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce, and for...

  12. 32 CFR 32.15 - Metric system of measurement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Metric system of measurement. 32.15 Section 32..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 32.15 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce, and for...

  13. 32 CFR 32.15 - Metric system of measurement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Metric system of measurement. 32.15 Section 32..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 32.15 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce, and for...

  14. 32 CFR 32.15 - Metric system of measurement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Metric system of measurement. 32.15 Section 32..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 32.15 Metric system of measurement...) declares that the metric system is the preferred measurement system for U.S. trade and commerce, and for...

  15. National Exposure Research Laboratory

    EPA Pesticide Factsheets

    The Ecosystems Research Division of EPA’s National Exposure Research Laboratory, conducts research on organic and inorganic chemicals, greenhouse gas biogeochemical cycles, and land use perturbations that create stressor exposures and potentia risk

  16. Characterization of Fe3O4/SiO2/Gd2O(CO3)2 core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent.

    PubMed

    Yang, Meicheng; Gao, Lipeng; Liu, Kai; Luo, Chunhua; Wang, Yiting; Yu, Lei; Peng, Hui; Zhang, Wen

    2015-01-01

    Core/shell/shell structured Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles were successfully synthesized. Their properties as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging were investigated. Due to the introduce of a separating SiO2 layer, the magnetic coupling between Gd2O(CO3)2 and Fe3O4 could be modulated by the thickness of SiO2 layer and produce appropriate T1 and T2 signal. Additionally, the existence of Gd(3+) enhances the transverse relaxivity of Fe3O4 possibly because of the magnetic coupling between Gd(3+) and Fe3O4. The Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles exhibit good biocompatibility, showing great potential for biomedical applications. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. 32 CFR 553.15a - Persons eligible for inurnment of cremated remains in Columbarium in Arlington National Cemetery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Persons eligible for inurnment of cremated remains in Columbarium in Arlington National Cemetery. 553.15a Section 553.15a National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES ARMY...

  18. 32 CFR 219.122 - Use of Federal funds.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Use of Federal funds. 219.122 Section 219.122 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED... department or agency may not be expended for research involving human subjects unless the requirements of...

  19. National Programs | Frederick National Laboratory for Cancer Research

    Cancer.gov

    The Frederick National Laboratoryis a shared national resource that offers access to a suite of advanced biomedical technologies, provides selected science and technology services, and maintains vast repositories of research materials available

  20. National Center on Sleep Disorders Research

    MedlinePlus

    ... for Updates The National Center on Sleep Disorders Research (NCSDR) Located within the National Heart, Lung, and ... key functions: research, training, technology transfer, and coordination. Research Sleep disorders span many medical fields, requiring multidisciplinary ...

  1. 48 CFR 32.202-3 - Conducting market research about financing terms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Conducting market research... 32.202-3 Conducting market research about financing terms. Contract financing may be a subject included in the market research conducted in accordance with part 10. If market research for contract...

  2. 48 CFR 32.202-3 - Conducting market research about financing terms.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Conducting market research... 32.202-3 Conducting market research about financing terms. Contract financing may be a subject included in the market research conducted in accordance with part 10. If market research for contract...

  3. National Institute of Dental and Craniofacial Research

    MedlinePlus

    ... In Skip to Main Content National Institute of Dental and Craniofacial Research (NIDCR) Improving the Nation's Oral ... Researchers NIDCR Strategic Plan The National Institute of Dental and Craniofacial Research remains committed to improving the ...

  4. 32 CFR 32.45 - Cost and price analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Cost and price analysis. 32.45 Section 32.45... price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every procurement action. Price analysis may be accomplished in various ways...

  5. 76 FR 2083 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research.... ACTION: Notice of Public Comment Period for the revised Jobos Bay National Estuarine Research Reserve... revised Jobos Bay National Estuarine Research Reserve Management Plan. The Jobos Bay National Estuarine...

  6. 75 FR 65613 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research... Research Reserves: North Inlet-Winyah Bay, SC and San Francisco Bay, CA. SUMMARY: Notice is hereby given... National Estuarine Research Reserve and the San Francisco Bay, CA National Estuarine Research Reserve. The...

  7. 76 FR 16620 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research... Research Reserves: ACE Basin, SC and Old Woman Creek, OH. SUMMARY: Notice is hereby given that the... National Estuarine Research Reserve and Old Woman Creek, OH National Estuarine Research Reserve. The...

  8. 78 FR 50038 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research.... ACTION: Notice of Public Comment Period for the Wells, Maine National Estuarine Research Reserve... National Estuarine Research [[Page 50039

  9. National Institute of Nursing Research

    MedlinePlus

    ... Page Level Navigation NINR - National Institute of Nursing Research NINR New Director’s Message Marks Two November Awareness ... science. Read More > Nursing Research WHAT IS NURSING RESEARCH? Nursing research develops knowledge to: Build the scientific ...

  10. Impact of intra-tumoral IL17A and IL32 gene expression on T-cell responses and lymph node status in breast cancer patients

    PubMed Central

    Bhat, Shreyas; Gardi, Nilesh; Hake, Sujata; Kotian, Nirupama; Sawant, Sharada; Kannan, Sadhana; Parmar, Vani; Desai, Sangeeta; Dutt, Amit

    2018-01-01

    Purpose Pro-inflammatory cytokines such as Interleukin-17A (IL17A) and Interleukin-32 (IL32), known to enhance natural killer and T cell responses, are also elevated in human malignancies and linked to poor clinical outcomes. To address this paradox, we evaluated relation between IL17A and IL32 expression and other inflammation- and T cell response-associated genes in breast tumors. Methods TaqMan-based gene expression analysis was carried out in seventy-eight breast tumors. The association between IL17A and IL32 transcript levels and T cell response genes, ER status as well as lymph node status was also examined in breast tumors from TCGA dataset. Results IL17A expression was detected in 32.7% ER-positive and 84.6% ER-negative tumors, with higher expression in the latter group (26.2 vs 7.1-fold, p < 0.01). ER-negative tumors also showed higher expression of IL32 as opposed to ER-positive tumors (8.7 vs 2.5-fold, p < 0.01). Expression of both IL17A and IL32 genes positively correlated with CCL5, GNLY, TBX21, IL21 and IL23 transcript levels (p < 0.01). Amongst ER-positive tumors, higher IL32 expression significantly correlated with lymph node metastases (p < 0.05). Conversely, in ER-negative subtype, high IL17A and IL32 expression was seen in patients with negative lymph node status (p < 0.05). Tumors with high IL32 and IL17A expression showed higher expression of TH1 response genes studied, an observation validated by similar analysis in the TCGA breast tumors (n=1041). Of note, these tumors were characterized by low expression of a potentially immunosuppressive isoform of IL32 (IL32γ). Conclusion These results suggest that high expression of both IL17A and IL32 leads to enhancement of T cell responses. Our study, thus, provides basis for the emergence of strong T cell responses in an inflammatory milieu that have been shown to be associated with better prognosis in ER-negative breast cancer. PMID:28470472

  11. 78 FR 75548 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research...: Notice of Approval of the Wells, Maine National Estuarine Research Reserve Management Plan revision... Commerce approves the Wells, Maine National Estuarine Research Reserve Management Plan revision. The...

  12. 78 FR 26617 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research.... ACTION: Notice of Public Comment Period for the Grand Bay, Mississippi National Estuarine Research Reserve Management Plan and the Delaware National Estuarine Research Reserve Management Plan revisions...

  13. National Research Council Research Associateships Program with Methane Hydrates Fellowships Program/National Energy Technology Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Basques, Eric O.

    2014-03-20

    This report summarizes work carried out over the period from July 5, 2005-January 31, 2014. The work was carried out by the National Research Council Research Associateships Program of the National Academies, under the US Department of Energy's National Energy Technology Laboratory (NETL) program. This Technical Report consists of a description of activity from 2005 through 2014, broken out within yearly timeframes, for NRC/NETL Associateships researchers at NETL laboratories which includes individual tenure reports from Associates over this time period. The report also includes individual tenure reports from associates over this time period. The report also includes descriptions of programmore » promotion efforts, a breakdown of the review competitions, awards offered, and Associate's activities during their tenure.« less

  14. Nonlytic Fc-fused IL-7 synergizes with Mtb32 DNA vaccine to enhance antigen-specific T cell responses in a therapeutic model of tuberculosis.

    PubMed

    Ahn, So-Shin; Jeon, Bo-Young; Park, Seong-Jeong; Choi, Dong-Hoon; Ku, Sun-Hwa; Cho, Sang-Nae; Sung, Young-Chul

    2013-06-12

    Improvement to the immunogenicity of DNA vaccines was evaluated in a Mycobacterium tuberculosis (MTB) infection mouse model examining the combined effects of nonlytic Fc-fused IL-7 DNA (IL-7-nFc) and Flt3-ligand fused Mtb32 (F-Mtb32) DNA. Mice were treated with conventional chemotherapy for 6 weeks from 4 weeks after aerosol infection of MTB. Following the start of chemotherapy, DNA immunizations were administered five times with 2-week intervals. Coadministration of IL-7-nFc and F-Mtb32 DNA given during chemotherapy synergistically enhanced the magnitude of Mtb32-specific T cell responses and sustained for one-year after the last immunization assessed by IFN-γ ELISPOT assay. After dexamethasone treatment, a significantly reduced MTB reactivation was observed in mice received both IL-7-nFc and F-Mtb32 DNA, compared with F-MTb32 DNA alone or with control mice. In addition, mice treated with IL-7-nFc and F-Mtb32 DNA together showed improved lung pathology and reduced pulmonary inflammation values relative to F-Mtb32 DNA or saline injected mice. Intracellular cytokine staining revealed that the protection levels induced by combination therapy with IL-7-nFc and F-Mtb32 DNA was associated with enhanced Mtb32-specific IFN-γ secreting CD4(+) T cell responses and CD8(+) T cell responses stimulated with CTL epitope peptide in the lungs and spleens. These data suggest that IL-7-nFc as a novel TB adjuvant may facilitate therapeutic TB DNA vaccine to the clinics through significant enhancement of codelivered DNA vaccine-induced T cell immunity. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. 32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

  16. 32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

  17. 32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

  18. 32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

  19. 32 CFR 174.15 - Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Indemnification under Section 330 of the National Defense Authorization Act for Fiscal Year 1993. 174.15 Section 174.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CLOSURES AND REALIGNMENT REVITALIZING BASE CLOSURE COMMUNITIES AND ADDRESSING IMPACTS OF REALIGNMENT...

  20. Structural and functional role of bases 32 and 33 in the anticodon loop of yeast mitochondrial tRNAIle

    PubMed Central

    Montanari, Arianna; De Luca, Cristina; Di Micco, Patrizio; Morea, Veronica; Frontali, Laura; Francisci, Silvia

    2011-01-01

    Previous work has demonstrated the usefulness of the yeast model to investigate the molecular mechanisms underlying defects due to base substitutions in mitochondrial tRNA genes, and to identify suppressing molecules endowed with potential clinical relevance. The present paper extends these investigations to two human equivalent yeast mutations located at positions 32 and 33 in the anticodon loop of tRNAIle. Notwithstanding the proximity of the two T>C base substitutions, the effects of these mutations have been found to be quite different in yeast, as they are in human. The T32C substitution has a very severe effect in yeast, consisting in a complete inhibition of growth on nonfermentable substrates. Conversely, respiratory defects caused by the T33C mutation could only be observed in a defined genetic context. Analyses of available sequences and selected tRNA three-dimensional structures were performed to provide explanations for the different behavior of these adjacent mutations. Examination of the effects of previously identified suppressors demonstrated that overexpression of the TUF1 gene did not rescue the defective phenotypes determined by either mutation, possibly as a consequence of the lack of interactions between EF-Tu and the tRNA anticodon arm in known structures. On the contrary, both the cognate IleRS and the noncognate LeuRS and ValRS are endowed with suppressing activities toward both mutations. This allows us to extend to the tRNAIle mutants the cross-suppression activity of aminoacyl-tRNA synthetases previously demonstrated for tRNALeu and tRNAVal mutants. PMID:21914842

  1. 75 FR 49887 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research... Research Reserves: Narragansett Bay, RI and Tijuana River, CA. SUMMARY: Notice is hereby given that the... Research Reserve and the Tijuana, CA National Estuarine Research Reserve. The Narragansett Bay, RI Reserve...

  2. FATE & EFFECTS OF AGRICULTURAL PESTICIDES WITHIN WEEKS BAY WATERSHED, A NATIONAL ESTUARINE RESEARCH RESERVE

    EPA Science Inventory

    Lytle, J.S., T.F. Lytle and M.A. Lewis. In press. Fate and Effects of Agricultural Pesticides Within Weeks Bay Watershed, a National Estuarine Research Preserve. To be presented at the 24th Annual Meeting in North America of the Society of Environmental Toxicology and Chemistry: ...

  3. Surgical research using national databases

    PubMed Central

    Leland, Hyuma; Heckmann, Nathanael

    2016-01-01

    Recent changes in healthcare and advances in technology have increased the use of large-volume national databases in surgical research. These databases have been used to develop perioperative risk stratification tools, assess postoperative complications, calculate costs, and investigate numerous other topics across multiple surgical specialties. The results of these studies contain variable information but are subject to unique limitations. The use of large-volume national databases is increasing in popularity, and thorough understanding of these databases will allow for a more sophisticated and better educated interpretation of studies that utilize such databases. This review will highlight the composition, strengths, and weaknesses of commonly used national databases in surgical research. PMID:27867945

  4. Surgical research using national databases.

    PubMed

    Alluri, Ram K; Leland, Hyuma; Heckmann, Nathanael

    2016-10-01

    Recent changes in healthcare and advances in technology have increased the use of large-volume national databases in surgical research. These databases have been used to develop perioperative risk stratification tools, assess postoperative complications, calculate costs, and investigate numerous other topics across multiple surgical specialties. The results of these studies contain variable information but are subject to unique limitations. The use of large-volume national databases is increasing in popularity, and thorough understanding of these databases will allow for a more sophisticated and better educated interpretation of studies that utilize such databases. This review will highlight the composition, strengths, and weaknesses of commonly used national databases in surgical research.

  5. Genetic alteration of the metal/redox modulation of Cav3.2 T-type calcium channel reveals its role in neuronal excitability.

    PubMed

    Voisin, Tiphaine; Bourinet, Emmanuel; Lory, Philippe

    2016-07-01

    In this study, we describe a new knock-in (KI) mouse model that allows the study of the H191-dependent regulation of T-type Cav3.2 channels. Sensitivity to zinc, nickel and ascorbate of native Cav3.2 channels is significantly impeded in the dorsal root ganglion (DRG) neurons of this KI mouse. Importantly, we describe that this H191-dependent regulation has discrete but significant effects on the excitability properties of D-hair (down-hair) cells, a sub-population of DRG neurons in which Cav3.2 currents prominently regulate excitability. Overall, this study reveals that the native H191-dependent regulation of Cav3.2 channels plays a role in the excitability of Cav3.2-expressing neurons. This animal model will be valuable in addressing the potential in vivo roles of the trace metal and redox modulation of Cav3.2 T-type channels in a wide range of physiological and pathological conditions. Cav3.2 channels are T-type voltage-gated calcium channels that play important roles in controlling neuronal excitability, particularly in dorsal root ganglion (DRG) neurons where they are involved in touch and pain signalling. Cav3.2 channels are modulated by low concentrations of metal ions (nickel, zinc) and redox agents, which involves the histidine 191 (H191) in the channel's extracellular IS3-IS4 loop. It is hypothesized that this metal/redox modulation would contribute to the tuning of the excitability properties of DRG neurons. However, the precise role of this H191-dependent modulation of Cav3.2 channel remains unresolved. Towards this goal, we have generated a knock-in (KI) mouse carrying the mutation H191Q in the Cav3.2 protein. Electrophysiological studies were performed on a subpopulation of DRG neurons, the D-hair cells, which express large Cav3.2 currents. We describe an impaired sensitivity to zinc, nickel and ascorbate of the T-type current in D-hair neurons from KI mice. Analysis of the action potential and low-threshold calcium spike (LTCS) properties revealed

  6. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice

    PubMed Central

    Wang, Xue-Long; Tian, Bin; Huang, Ya; Peng, Xiao-Yan; Chen, Li-Hua; Li, Jun-Cheng; Liu, Tong

    2015-01-01

    The contributions of gasotransmitters to itch sensation are largely unknown. In this study, we aimed to investigate the roles of hydrogen sulfide (H2S), a ubiquitous gasotransmitter, in itch signaling. We found that intradermal injection of H2S donors NaHS or Na2S, but not GYY4137 (a slow-releasing H2S donor), dose-dependently induced scratching behavior in a μ-opioid receptor-dependent and histamine-independent manner in mice. Interestingly, NaHS induced itch via unique mechanisms that involved capsaicin-insensitive A-fibers, but not TRPV1-expressing C-fibers that are traditionally considered for mediating itch, revealed by depletion of TRPV1-expressing C-fibers by systemic resiniferatoxin treatment. Moreover, local application of capsaizapine (TRPV1 blocker) or HC-030031 (TRPA1 blocker) had no effects on NaHS-evoked scratching. Strikingly, pharmacological blockade and silencing of Cav3.2 T-type calcium channel by mibefradil, ascorbic acid, zinc chloride or Cav3.2 siRNA dramatically decreased NaHS-evoked scratching. NaHS induced robust alloknesis (touch-evoked itch), which was inhibited by T-type calcium channels blocker mibefradil. Compound 48/80-induced itch was enhanced by an endogenous precursor of H2S (L-cysteine) but attenuated by inhibitors of H2S-producing enzymes cystathionine γ-lyase and cystathionine β-synthase. These results indicated that H2S, as a novel nonhistaminergic itch mediator, may activates Cav3.2 T-type calcium channel, probably located at A-fibers, to induce scratching and alloknesis in mice. PMID:26602811

  7. 77 FR 60107 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research... Research Reserve Management Plan Revisions. SUMMARY: Notice is hereby given that the Estuarine Reserves..., Alaska National Estuarine Research Reserve Management Plan Revisions. The revised management plans...

  8. 78 FR 53732 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research.... ACTION: Notice of approval of the Grand Bay, Mississippi and Delaware National Estuarine Research Reserve... Estuarine Research Reserve Management Plan Revisions. The revised management plans outline the...

  9. Evaluation of image quality of a 32-channel versus a 12-channel head coil at 1.5T for MR imaging of the brain.

    PubMed

    Parikh, P T; Sandhu, G S; Blackham, K A; Coffey, M D; Hsu, D; Liu, K; Jesberger, J; Griswold, M; Sunshine, J L

    2011-02-01

    Multichannel phased-array head coils are undergoing exponential escalation of coil element numbers. While previous technical studies have found gains in SNR and spatial resolution with the addition of element coils, it remains to be determined how these gains affect clinical reading. The purpose of this clinical study was to determine if the SNR and spatial resolution characteristics of a 32-channel head coil result in improvements in perceived image quality and lesion evaluation. Twenty-one patients underwent MR imaging of the brain at 1.5T sequentially with both a 12-channel and a 32-channel receive-only phased-array head coil. Axial T2WIs, T1WIs, FLAIR images, and DWIs were acquired. Anonymized images were compared side-by-side and by sequence for image quality, lesion evaluation, and artifacts by 3 neuroradiologists. Results of the comparison were analyzed for the preference for a specific head coil. FLAIR and DWI images acquired with the 32-channel coil showed significant improvement in image quality in several parameters. T2WIs also improved significantly with acquisition by the 32-channel coil, while T1WIs improved in a limited number of parameters. While lesion evaluation also improved with acquisition of images by the 32-channel coil, there was no apparent improvement in diagnostic quality. There was no difference in artifacts between the 2 coils. Improvements in SNR and spatial resolution attributed to image acquisition with a 32-channel head coil are paralleled by perceived improvements in image quality.

  10. National Institutes of Health eliminates funding for national architecture linking primary care research.

    PubMed

    Peterson, Kevin A

    2007-01-01

    With the ending of the National Electronic Clinical Trial and Research Network (NECTAR) pilot programs and the abridgement of Clinical Research Associate initiative, the National Institutes of Health Roadmap presents a strategic shift for practice-based research networks from direct funding of a harmonized national infrastructure of cooperating research networks to a model of local engagement of primary care clinics performing practice-based research under the aegis of regional academic health centers through Clinical and Translational Science Awards. Although this may present important opportunities for partnering between community practices and large health centers, for primary care researchers, the promise of a transformational change that brings a unified national primary care community into the clinical research enterprise seems likely to remain unfulfilled.

  11. Reinterpretation of the Vibrational Spectroscopy of the Medicinal Bioinorganic Synthon c,c,t-[Pt(NH3)2Cl2(OH)2]†

    PubMed Central

    Johnstone, Timothy C.

    2014-01-01

    The Pt(IV) complex c,c,t-[Pt(NH3)2Cl2(OH)2] is an important intermediate in the synthesis of Pt(IV) anticancer prodrugs and has been investigated as an anticancer agent in its own right. An analysis of the vibrational spectroscopy of this molecule was previously reported [Faggiani et al., 1982, Can. J. Chem. 60, 529] in which crystallographic determination of the structure of the complex permitted a site group approach. The space group, however, was incorrectly assigned. In the present study we have redetermined at high resolution crystal structures of c,c,t-[Pt(NH3)2Cl2(OH)2] and c,c,t-[Pt(NH3)2Cl2(OH)2]·H2O2, which enable discussion of the effect of hydrogen bonding on the N–H and O–H vibrational bands. The correct crystallographic site symmetry of the platinum complex in the c,c,t-[Pt(NH3)2Cl2(OH)2] structure is employed to conduct a new vibrational analysis using both group theoretical and modern DFT methods. This analysis reveals the nature and symmetry of the “missing band” described in the original publication and suggests a possible explanation for its disappearance. PMID:24515615

  12. 75 FR 59696 - National Estuarine Research Reserve System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration National Estuarine Research... Estuarine Research Reserves: Arraigns Bay, RI and Tijuana River, CA. SUMMARY: Notice is hereby given that... the revised management plans of the Arraigns Bay, RI National Estuarine Research Reserve and the...

  13. 32 CFR 720.32 - Certificates of full faith and credit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Certificates of full faith and credit. 720.32... Official Records § 720.32 Certificates of full faith and credit. The Judge Advocate General, the Deputy... full faith and credit certifying the signatures and authority of officers of the Department of the Navy...

  14. 32 CFR 720.32 - Certificates of full faith and credit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Certificates of full faith and credit. 720.32... Official Records § 720.32 Certificates of full faith and credit. The Judge Advocate General, the Deputy... full faith and credit certifying the signatures and authority of officers of the Department of the Navy...

  15. 32 CFR 720.32 - Certificates of full faith and credit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Certificates of full faith and credit. 720.32... Official Records § 720.32 Certificates of full faith and credit. The Judge Advocate General, the Deputy... full faith and credit certifying the signatures and authority of officers of the Department of the Navy...

  16. 32 CFR 720.32 - Certificates of full faith and credit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Certificates of full faith and credit. 720.32... Official Records § 720.32 Certificates of full faith and credit. The Judge Advocate General, the Deputy... full faith and credit certifying the signatures and authority of officers of the Department of the Navy...

  17. 32 CFR 720.32 - Certificates of full faith and credit.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Certificates of full faith and credit. 720.32... Official Records § 720.32 Certificates of full faith and credit. The Judge Advocate General, the Deputy... full faith and credit certifying the signatures and authority of officers of the Department of the Navy...

  18. 17 CFR 240.11a1-4(T) - Bond transactions on national securities exchanges.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Bond transactions on national securities exchanges. 240.11a1-4(T) Section 240.11a1-4(T) Commodity and Securities Exchanges SECURITIES AND....11a1-4(T) Bond transactions on national securities exchanges. A transaction in a bond, note, debenture...

  19. 17 CFR 240.11a1-4(T) - Bond transactions on national securities exchanges.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Bond transactions on national securities exchanges. 240.11a1-4(T) Section 240.11a1-4(T) Commodity and Securities Exchanges SECURITIES AND....11a1-4(T) Bond transactions on national securities exchanges. A transaction in a bond, note, debenture...

  20. 32 CFR 776.32 - Department of the Navy as client.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Department of the Navy as client. 776.32 Section... Rules of Professional Conduct § 776.32 Department of the Navy as client. (a) Department of Navy as client: (1) Except when representing an individual client pursuant to paragraph (a)(6) of this section, a...

  1. 32 CFR 100.6 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Definitions. 100.6 Section 100.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... extended active duty. (See 10 U.S.C. 268(b) 32 CFR part 102.) (3) Members of the Inactive Army National...

  2. 32 CFR 100.6 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Definitions. 100.6 Section 100.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... extended active duty. (See 10 U.S.C. 268(b) 32 CFR part 102.) (3) Members of the Inactive Army National...

  3. 32 CFR 100.6 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Definitions. 100.6 Section 100.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... extended active duty. (See 10 U.S.C. 268(b) 32 CFR part 102.) (3) Members of the Inactive Army National...

  4. The Research Focus of Nations: Economic vs. Altruistic Motivations

    PubMed Central

    2017-01-01

    What motivates the research strategies of nations and institutions? We suggest that research primarily serves two masters–altruism and economic growth. Some nations focus more research in altruistic (or non-economic) fields while others focus more research in fields associated with economic growth. What causes this difference? Are there characteristics that would suggest why a nation is more aligned with altruism or economic growth? To answer this question, we have identified nine major fields of research by analyzing the publication activity of 4429 institutions using Scopus data. Two fields of research are clearly altruistic (there is relatively little involvement by industry) and two fields are clearly aligned with economic growth. The altruistic vs. economic nature of nations based on their publication profiles across these fields is correlated with national indicators on wealth, education, capitalism, individualism, power, religion, and language. While previous research has suggested that national research strategy is aligned with national wealth, our analysis shows that national wealth is not highly correlated with the tradeoff between altruistic and economic motives. Instead, the tradeoff is largely captured by a culture of individualism. Accordingly, implications for national research strategies are discussed. PMID:28056043

  5. The Research Focus of Nations: Economic vs. Altruistic Motivations.

    PubMed

    Klavans, Richard; Boyack, Kevin W

    2017-01-01

    What motivates the research strategies of nations and institutions? We suggest that research primarily serves two masters-altruism and economic growth. Some nations focus more research in altruistic (or non-economic) fields while others focus more research in fields associated with economic growth. What causes this difference? Are there characteristics that would suggest why a nation is more aligned with altruism or economic growth? To answer this question, we have identified nine major fields of research by analyzing the publication activity of 4429 institutions using Scopus data. Two fields of research are clearly altruistic (there is relatively little involvement by industry) and two fields are clearly aligned with economic growth. The altruistic vs. economic nature of nations based on their publication profiles across these fields is correlated with national indicators on wealth, education, capitalism, individualism, power, religion, and language. While previous research has suggested that national research strategy is aligned with national wealth, our analysis shows that national wealth is not highly correlated with the tradeoff between altruistic and economic motives. Instead, the tradeoff is largely captured by a culture of individualism. Accordingly, implications for national research strategies are discussed.

  6. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  7. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  8. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  9. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  10. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  11. National Space Biomedical Research Institute

    NASA Technical Reports Server (NTRS)

    2003-01-01

    In June 1996, NASA released a Cooperative Agreement Notice (CAN) inviting proposals to establish a National Space Biomedical Research Institute (9-CAN-96-01). This CAN stated that: The Mission of the Institute will be to lead a National effort for accomplishing the integrated, critical path, biomedical research necessary to support the long term human presence, development, and exploration of space and to enhance life on Earth by applying the resultant advances in human knowledge and technology acquired through living and working in space. The Institute will be the focal point of NASA sponsored space biomedical research. This statement has not been amended by NASA and remains the mission of the NSBRI.

  12. 32 CFR Appendix G to Part 197 - Procedures for Copying Documents

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Procedures for Copying Documents G Appendix G to Part 197 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt...

  13. 32 CFR Appendix G to Part 197 - Procedures for Copying Documents

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Procedures for Copying Documents G Appendix G to Part 197 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt...

  14. 32 CFR Appendix G to Part 197 - Procedures for Copying Documents

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Procedures for Copying Documents G Appendix G to Part 197 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt...

  15. 32 CFR Appendix G to Part 197 - Procedures for Copying Documents

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Procedures for Copying Documents G Appendix G to Part 197 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt...

  16. 32 CFR Appendix G to Part 197 - Procedures for Copying Documents

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Procedures for Copying Documents G Appendix G to Part 197 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt...

  17. 34 CFR 350.32 - What activities must a Rehabilitation Engineering Research Center conduct?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What activities must a Rehabilitation Engineering... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Engineering Research Centers Does the Secretary Assist? § 350.32 What activities must a Rehabilitation Engineering Research...

  18. 34 CFR 350.32 - What activities must a Rehabilitation Engineering Research Center conduct?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false What activities must a Rehabilitation Engineering... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Engineering Research Centers Does the Secretary Assist? § 350.32 What activities must a Rehabilitation Engineering Research...

  19. 34 CFR 350.32 - What activities must a Rehabilitation Engineering Research Center conduct?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false What activities must a Rehabilitation Engineering... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Engineering Research Centers Does the Secretary Assist? § 350.32 What activities must a Rehabilitation Engineering Research...

  20. 34 CFR 350.32 - What activities must a Rehabilitation Engineering Research Center conduct?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true What activities must a Rehabilitation Engineering... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Engineering Research Centers Does the Secretary Assist? § 350.32 What activities must a Rehabilitation Engineering Research...

  1. 34 CFR 350.32 - What activities must a Rehabilitation Engineering Research Center conduct?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true What activities must a Rehabilitation Engineering... DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM What Rehabilitation Engineering Research Centers Does the Secretary Assist? § 350.32 What activities must a Rehabilitation Engineering Research...

  2. 32 CFR 2400.32 - Transmittal of classified information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 2400.32 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION... classified information outside of the Office of Science and Technology Policy shall be in accordance with...

  3. 32 CFR 2400.32 - Transmittal of classified information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 2400.32 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION... classified information outside of the Office of Science and Technology Policy shall be in accordance with...

  4. 32 CFR 2400.32 - Transmittal of classified information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 2400.32 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION... classified information outside of the Office of Science and Technology Policy shall be in accordance with...

  5. 32 CFR 2400.32 - Transmittal of classified information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 2400.32 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION... classified information outside of the Office of Science and Technology Policy shall be in accordance with...

  6. 32 CFR 2400.32 - Transmittal of classified information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 2400.32 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION... classified information outside of the Office of Science and Technology Policy shall be in accordance with...

  7. γ spectroscopy of states in Cl 32 relevant for the S 31 ( p , γ ) Cl 32 reaction rate

    DOE PAGES

    Afanasieva, L.; Blackmon, J. C.; Deibel, C. M.; ...

    2017-09-01

    Background: The 31S(p,gamma) 32Cl reaction becomes important for sulfur production in novae if the P-31(p, alpha)Si-28 reaction rate is somewhat greater than currently accepted. The rate of the S-31(p,gamma) Cl-32 reaction is uncertain, primarily due to the properties of resonances at E-c.m. = 156 and 549 keV. Purpose: We precisely determined the excitation energies of states in Cl-32 through high-resolution. spectroscopy including the two states most important for the S-31(p,gamma) Cl-32 reaction at nova temperatures. Method: Excited states in Cl-32 were populated using the B-10(Mg-24, 2n) Cl-32 reaction with a Mg-24 beam from the ATLAS facility at Argonne National Laboratory.more » The reaction channel of interest was selected using recoils in the Fragment Mass Analyzer, and we determined precise level energies by detecting. rays with Gammasphere. Results: We also observed. rays from the decay of six excited states in Cl-32. The excitation energies for two unbound levels at E-x = 1738.1 (6) keV and 2130.5 (10) keV were determined and found to be in agreement with a previous high-precision measurement of the S-32(He-3, t) Cl-32 reaction [1]. Conclusions: An updated 31S(p,gamma) Cl-32 reaction rate is presented. With the excitation energies of important levels firmly established, the dominant uncertainty in the reaction rate at nova temperatures is due to the strength of the resonance corresponding to the 2131-keV state in Cl-32.« less

  8. National action for European public health research.

    PubMed

    McCarthy, Mark; Zeegers Paget, Dineke; Barnhoorn, Floris

    2013-11-01

    Research and innovation are the basis for improving health and health services. The European Union (EU) supports research through multi-annual programmes. Public Health Innovation and Research in Europe (PHIRE) investigated how European countries cooperate for action in public health research. In PHIRE, following stakeholder workshops and consultations, a national report on public health research was created for 24 of 30 European countries. The report template asked five questions, on national links to European public health research and on national research through the Structural Funds and Ministry of Health. The national reports were assessed with framework analysis, and the country actions were classified strong/partial/weak or none. There were responses to the five questions sufficient for this analysis for between 14 and 20 countries Six countries had public health research aligned with the EU, while three (large) countries were reported not aligned. Only two countries expressed strong engagement in developing public health research within Horizon 2020: most Ministries of Health had no position and only had contact with EU health research through other ministries. Only two countries reported use of the 2007-13 Structural Funds for public health research. While seven Ministries of Health led research from their own funds, or linked with Ministries of Science in six, the Ministries of Health of seven countries were reported not to be involved in public health research. Ministries of Health and stakeholders are poorly engaged in developing public health research, with the Horizon 2020 research programme, or the Structural Funds. The European Commission should give more attention to coordination of public health research with member states if it is to give best value to European citizens.

  9. 32 CFR 1800.32 - Procedures for information concerning other persons.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Procedures for information concerning other... Administrative Matters § 1800.32 Procedures for information concerning other persons. (a) In general. Personal information concerning individuals other than the requester shall not be disclosed under the Freedom of...

  10. 32 CFR 1900.32 - Procedures for information concerning other persons.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Procedures for information concerning other... Administrative Matters § 1900.32 Procedures for information concerning other persons. (a) In general. Personal information concerning individuals other than the requester shall not be disclosed under the Freedom of...

  11. 21 CFR 1301.32 - Action on applications for research in Schedule I substances.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Action on applications for research in Schedule I... Registration: Revocation Or Suspension of Registration § 1301.32 Action on applications for research in Schedule I substances. (a) In the case of an application for registration to conduct research with...

  12. 32 CFR 621.1 - Loan of Army/Defense Logistics Agency (DLA) owned property for use at national and State...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Loan of Army/Defense Logistics Agency (DLA) owned... of Army/Defense Logistics Agency (DLA) owned property for use at national and State conventions. (a... will be submitted to the appropriate CONUS Army Commander of the area in which the convention will be...

  13. 32 CFR 621.1 - Loan of Army/Defense Logistics Agency (DLA) owned property for use at national and State...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Loan of Army/Defense Logistics Agency (DLA) owned... of Army/Defense Logistics Agency (DLA) owned property for use at national and State conventions. (a... will be submitted to the appropriate CONUS Army Commander of the area in which the convention will be...

  14. 32 CFR 621.1 - Loan of Army/Defense Logistics Agency (DLA) owned property for use at national and State...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Loan of Army/Defense Logistics Agency (DLA) owned... of Army/Defense Logistics Agency (DLA) owned property for use at national and State conventions. (a... will be submitted to the appropriate CONUS Army Commander of the area in which the convention will be...

  15. National roadmap for research infrastructure

    NASA Astrophysics Data System (ADS)

    Bonev, Tanyu

    In 2010 the Council of Ministers of Republic of Bulgaria passed a National roadmap for research infrastructure (Decision Num. 692 from 21.09.2010). Part of the roadmap is the project called Regional Astronomical Center for Research and Education (RACIO). Distinctive feature of this project is the integration of the existing in the country research and educational organizations in the field of astronomy. The project is a substantial part of the strategy for the development of astronomy in Bulgaria over the next decade. What is the content of this strategis project? How it was possible to include RACIO in the roadmap? Does the national roadmap charmonize with the strategic plans for the development of astronomy in Europe, elaborated by Astronet (http://www.astronet-eu.org/)? These are some of the questions which I try to give answers in this paper.

  16. 32 CFR 281.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Definitions. 281.3 Section 281.3 National... SETTLING PERSONNEL AND GENERAL CLAIMS AND PROCESSING ADVANCE DECISION REQUESTS § 281.3 Definitions. Armed.... 554, and 32 U.S.C. 714. Secretary concerned. The Secretary of the Army, addressing matters concerning...

  17. 32 CFR 281.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Definitions. 281.3 Section 281.3 National... SETTLING PERSONNEL AND GENERAL CLAIMS AND PROCESSING ADVANCE DECISION REQUESTS § 281.3 Definitions. Armed.... 554, and 32 U.S.C. 714. Secretary concerned. The Secretary of the Army, addressing matters concerning...

  18. 32 CFR 281.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Definitions. 281.3 Section 281.3 National... SETTLING PERSONNEL AND GENERAL CLAIMS AND PROCESSING ADVANCE DECISION REQUESTS § 281.3 Definitions. Armed.... 554, and 32 U.S.C. 714. Secretary concerned. The Secretary of the Army, addressing matters concerning...

  19. Research Plan for the National Center for Medical Rehabilitation Research.

    ERIC Educational Resources Information Center

    National Inst. of Child Health and Human Development (NIH), Bethesda, MD.

    This research plan describes a framework for defining and developing the field of rehabilitation sciences and research opportunities for the National Center for Medical Rehabilitation Research (NCMRR) and other agencies funding medical rehabilitation research. The plan addresses the needs of both persons who are involved in habilitation and in…

  20. 32 CFR 219.110 - Expedited review procedures for certain kinds of research involving no more than minimal risk...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 219.110 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE... 32 National Defense 2 2014-07-01 2014-07-01 false Expedited review procedures for certain kinds of... be amended, as appropriate after consultation with other departments and agencies, through periodic...

  1. 32 CFR 32.12 - Forms for applying for Federal assistance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... or the Catalog of Federal Domestic Assistance. The SPOC shall advise the applicant whether the... 32 National Defense 1 2013-07-01 2013-07-01 false Forms for applying for Federal assistance. 32.12... for Federal assistance. (a) DoD Components shall comply with the applicable report clearance...

  2. 32 CFR 32.12 - Forms for applying for Federal assistance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... or the Catalog of Federal Domestic Assistance. The SPOC shall advise the applicant whether the... 32 National Defense 1 2010-07-01 2010-07-01 false Forms for applying for Federal assistance. 32.12... for Federal assistance. (a) DoD Components shall comply with the applicable report clearance...

  3. 32 CFR 32.12 - Forms for applying for Federal assistance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... or the Catalog of Federal Domestic Assistance. The SPOC shall advise the applicant whether the... 32 National Defense 1 2014-07-01 2014-07-01 false Forms for applying for Federal assistance. 32.12... for Federal assistance. (a) DoD Components shall comply with the applicable report clearance...

  4. 32 CFR 32.12 - Forms for applying for Federal assistance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... or the Catalog of Federal Domestic Assistance. The SPOC shall advise the applicant whether the... 32 National Defense 1 2011-07-01 2011-07-01 false Forms for applying for Federal assistance. 32.12... for Federal assistance. (a) DoD Components shall comply with the applicable report clearance...

  5. 32 CFR 32.12 - Forms for applying for Federal assistance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... or the Catalog of Federal Domestic Assistance. The SPOC shall advise the applicant whether the... 32 National Defense 1 2012-07-01 2012-07-01 false Forms for applying for Federal assistance. 32.12... for Federal assistance. (a) DoD Components shall comply with the applicable report clearance...

  6. Partnering in research: a national research trial exemplifying effective collaboration with American Indian Nations and the Indian Health Service.

    PubMed

    Chadwick, Jennifer Q; Copeland, Kenneth C; Daniel, Mary R; Erb-Alvarez, Julie A; Felton, Beverly A; Khan, Sohail I; Saunkeah, Bobby R; Wharton, David F; Payan, Marisa L

    2014-12-15

    Despite the fact that numerous major public health problems have plagued American Indian communities for generations, American Indian participation in health research traditionally has been sporadic in many parts of the United States. In 2002, the University of Oklahoma Health Sciences Center (Oklahoma City, Oklahoma) and 5 Oklahoma American Indian research review boards (Oklahoma City Area Indian Health Service, Absentee Shawnee Tribe, Cherokee Nation, Chickasaw Nation, and Choctaw Nation) agreed to participate collectively in a national research trial, the Treatment Options for Type 2 Diabetes in Adolescence and Youth (TODAY) Study. During that process, numerous lessons were learned and processes developed that strengthened the partnerships and facilitated the research. Formal Memoranda of Agreement addressed issues related to community collaboration, venue, tribal authority, preferential hiring of American Indians, and indemnification. The agreements aided in uniting sovereign nations, the Indian Health Service, academics, and public health officials to conduct responsible and ethical research. For more than 10 years, this unique partnership has functioned effectively in recruiting and retaining American Indian participants, respecting cultural differences, and maintaining tribal autonomy through prereview of all study publications and local institutional review board review of all processes. The lessons learned may be of value to investigators conducting future research with American Indian communities. © The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  7. 32 CFR 169.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Purpose. 169.1 Section 169.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM § 169.1 Purpose. This document: (a) Revises 32 CFR part 169. (b) Updates DoD policies and assigns...

  8. 32 CFR 169.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Purpose. 169.1 Section 169.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM § 169.1 Purpose. This document: (a) Revises 32 CFR part 169. (b) Updates DoD policies and assigns...

  9. 32 CFR 169.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Purpose. 169.1 Section 169.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM § 169.1 Purpose. This document: (a) Revises 32 CFR part 169. (b) Updates DoD policies and assigns...

  10. 32 CFR 169.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Purpose. 169.1 Section 169.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM § 169.1 Purpose. This document: (a) Revises 32 CFR part 169. (b) Updates DoD policies and assigns...

  11. 32 CFR 212.4 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 212.4 Section 212.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROCEDURES AND....4 Policy. It is DoD policy, consistent with 32 CFR part 213, that procedures be established for the...

  12. 32 CFR 621.1 - Loan of Army/Defense Logistics Agency (DLA) owned property for use at national and State...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Loan of Army/Defense Logistics Agency (DLA... § 621.1 Loan of Army/Defense Logistics Agency (DLA) owned property for use at national and State... will be submitted to the appropriate CONUS Army Commander of the area in which the convention will be...

  13. 32 CFR 621.1 - Loan of Army/Defense Logistics Agency (DLA) owned property for use at national and State...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Loan of Army/Defense Logistics Agency (DLA... § 621.1 Loan of Army/Defense Logistics Agency (DLA) owned property for use at national and State... will be submitted to the appropriate CONUS Army Commander of the area in which the convention will be...

  14. Single-molecule FRET studies of the cooperative and non-cooperative binding kinetics of the bacteriophage T4 single-stranded DNA binding protein (gp32) to ssDNA lattices at replication fork junctions

    PubMed Central

    Lee, Wonbae; Gillies, John P.; Jose, Davis; Israels, Brett A.; von Hippel, Peter H.; Marcus, Andrew H.

    2016-01-01

    Gene 32 protein (gp32) is the single-stranded (ss) DNA binding protein of the bacteriophage T4. It binds transiently and cooperatively to ssDNA sequences exposed during the DNA replication process and regulates the interactions of the other sub-assemblies of the replication complex during the replication cycle. We here use single-molecule FRET techniques to build on previous thermodynamic studies of gp32 binding to initiate studies of the dynamics of the isolated and cooperative binding of gp32 molecules within the replication complex. DNA primer/template (p/t) constructs are used as models to determine the effects of ssDNA lattice length, gp32 concentration, salt concentration, binding cooperativity and binding polarity at p/t junctions. Hidden Markov models (HMMs) and transition density plots (TDPs) are used to characterize the dynamics of the multi-step assembly pathway of gp32 at p/t junctions of differing polarity, and show that isolated gp32 molecules bind to their ssDNA targets weakly and dissociate quickly, while cooperatively bound dimeric or trimeric clusters of gp32 bind much more tightly, can ‘slide’ on ssDNA sequences, and exhibit binding dynamics that depend on p/t junction polarities. The potential relationships of these binding dynamics to interactions with other components of the T4 DNA replication complex are discussed. PMID:27694621

  15. 27 CFR 24.32 - Records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Records. 24.32 Section 24.32 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... control number 1512-0298) [T.D. ATF-299, 55 FR 24989, June 19, 1990, as amended by T.D. ATF-409, 64 FR...

  16. 27 CFR 24.32 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Records. 24.32 Section 24.32 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... control number 1512-0298) [T.D. ATF-299, 55 FR 24989, June 19, 1990, as amended by T.D. ATF-409, 64 FR...

  17. 32 CFR 16.2 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Authority. 16.2 Section 16.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING § 16.2 Authority. This part is issued pursuant to 32 CFR 9.7(a) and in accordance with Military Order of November 13...

  18. 32 CFR 16.2 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Authority. 16.2 Section 16.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING § 16.2 Authority. This part is issued pursuant to 32 CFR 9.7(a) and in accordance with Military Order of November 13...

  19. 32 CFR 14.2 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Authority. 14.2 Section 14.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS QUALIFICATION OF CIVILIAN DEFENSE COUNSEL § 14.2 Authority. This part is issued pursuant to 32 CFR 9.7(a) and in accordance with...

  20. 32 CFR 14.2 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Authority. 14.2 Section 14.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS QUALIFICATION OF CIVILIAN DEFENSE COUNSEL § 14.2 Authority. This part is issued pursuant to 32 CFR 9.7(a) and in accordance with...

  1. 32 CFR 16.2 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Authority. 16.2 Section 16.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING § 16.2 Authority. This part is issued pursuant to 32 CFR 9.7(a) and in accordance with Military Order of November 13...

  2. 32 CFR 16.2 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Authority. 16.2 Section 16.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING § 16.2 Authority. This part is issued pursuant to 32 CFR 9.7(a) and in accordance with Military Order of November 13...

  3. 32 CFR 14.2 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Authority. 14.2 Section 14.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS QUALIFICATION OF CIVILIAN DEFENSE COUNSEL § 14.2 Authority. This part is issued pursuant to 32 CFR 9.7(a) and in accordance with...

  4. 32 CFR 14.2 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Authority. 14.2 Section 14.2 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS QUALIFICATION OF CIVILIAN DEFENSE COUNSEL § 14.2 Authority. This part is issued pursuant to 32 CFR 9.7(a) and in accordance with...

  5. 32 CFR 287.9 - Reports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Reports. 287.9 Section 287.9 National Defense... PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 287.9 Reports. An annual report will be furnished to the FOIA Officer by the field activities by 15 October IAW 32 CFR part 286. ...

  6. 32 CFR 287.9 - Reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Reports. 287.9 Section 287.9 National Defense... PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 287.9 Reports. An annual report will be furnished to the FOIA Officer by the field activities by 15 October IAW 32 CFR part 286. ...

  7. 32 CFR 287.9 - Reports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Reports. 287.9 Section 287.9 National Defense... PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 287.9 Reports. An annual report will be furnished to the FOIA Officer by the field activities by 15 October IAW 32 CFR part 286. ...

  8. 32 CFR 287.9 - Reports.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Reports. 287.9 Section 287.9 National Defense... PROGRAM DEFENSE INFORMATION SYSTEMS AGENCY FREEDOM OF INFORMATION ACT PROGRAM § 287.9 Reports. An annual report will be furnished to the FOIA Officer by the field activities by 15 October IAW 32 CFR part 286. ...

  9. Public Health Systems Research: Setting a National Agenda

    PubMed Central

    Lenaway, Dennis; Halverson, Paul; Sotnikov, Sergey; Tilson, Hugh; Corso, Liza; Millington, Wayne

    2006-01-01

    The Institute of Medicine has recommended that policy decisions about improvement of national public health systems be guided by sound scientific evidence. However, to date there is no national research agenda to help guide public health systems. The Centers for Disease Control and Prevention was called upon to lead a collaborative consensus-based process to define key research questions and establish a framework to create opportunities to better coordinate, leverage, and identify public health resources, which are increasingly scarce. The public health systems research agenda that emerged from this process has 14 overarching priority research themes. This national agenda should stimulate and guide research to meet the urgent need to improve the nation’s public health systems. PMID:16449601

  10. 50 CFR 259.32 - Conditional fisheries.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Conditional fisheries. 259.32 Section 259.32 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE AID TO FISHERIES CAPITAL CONSTRUCTION FUND Capital Construction Fund...

  11. National Melon Research Group

    USDA-ARS?s Scientific Manuscript database

    The National Melon Research Group met with the Cucurbitaceae 2010 conference in Charleston, South Carolina at 7:00 P.M. on November 17. The discussion was focused solely on cucurbit powdery mildew (CPM). Several reported increased problem with CPM or apparent changes in race. Ales Lebeda (Palacký Un...

  12. Alternan Research at the National Center for Agricultural Utilization Research

    USDA-ARS?s Scientific Manuscript database

    The Northern Regional Research Laboratory (later the National Center for Agricultural Utilization Research, or NCAUR) began operations on December 16, 1940. By the late 1940’s, Dr. Allene Jeanes was leading a team in an extensive research program on dextrans. Dextrans are glucan polysaccharides th...

  13. Alternan research at the National Center for Agricultural Utilization Research

    USDA-ARS?s Scientific Manuscript database

    The Northern Regional Research Laboratory (later the National Center for Agricultural Utilization Research, or NCAUR) began operations on December 16, 1940. By the late 1940’s, Dr. Allene Jeanes was leading a team in an extensive research program on dextrans. Dextrans are glucan polysaccharides th...

  14. Frederick National Laboratory and Georgetown University Launch Research and Education Collaboration | Frederick National Laboratory for Cancer Research

    Cancer.gov

    FREDERICK, Md. -- A new collaboration established between Georgetown University and the Frederick National Laboratory for Cancer Research aims to expand both institutions’ research and training missions in the biomedical sciences. Representatives f

  15. 32 CFR 22.505 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION National Policy Matters § 22.505 Purpose. The purpose of this subpart is... national policy requirements include: (a) The other parts of the DoDGARs (32 CFR parts 32, 33, and 34) that...

  16. 32 CFR 22.505 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION National Policy Matters § 22.505 Purpose. The purpose of this subpart is... national policy requirements include: (a) The other parts of the DoDGARs (32 CFR parts 32, 33, and 34) that...

  17. Idaho National Laboratory Research & Development Impacts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stricker, Nicole

    Technological advances that drive economic growth require both public and private investment. The U.S. Department of Energy’s national laboratories play a crucial role by conducting the type of research, testing and evaluation that is beyond the scope of regulators, academia or industry. Examples of such work from the past year can be found in these pages. Idaho National Laboratory’s engineering and applied science expertise helps deploy new technologies for nuclear energy, national security and new energy resources. Unique infrastructure, nuclear material inventory and vast expertise converge at INL, the nation’s nuclear energy laboratory. Productive partnerships with academia, industry and governmentmore » agencies deliver high-impact outcomes. This edition of INL’s Impacts magazine highlights national and regional leadership efforts, growing capabilities, notable collaborations, and technology innovations. Please take a few minutes to learn more about the critical resources and transformative research at one of the nation’s premier applied science laboratories.« less

  18. 32 CFR 842.103 - Filing a claim.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Filing a claim. 842.103 Section 842.103 National... CLAIMS Claims Under the National Guard Claims Act (32 U.S.C. 715) § 842.103 Filing a claim. This paragraph explains how to file a claim under the National Guard Claims Act. (a) How and when filed. A claim...

  19. 32 CFR 842.103 - Filing a claim.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Filing a claim. 842.103 Section 842.103 National... CLAIMS Claims Under the National Guard Claims Act (32 U.S.C. 715) § 842.103 Filing a claim. This paragraph explains how to file a claim under the National Guard Claims Act. (a) How and when filed. A claim...

  20. 32 CFR 842.103 - Filing a claim.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Filing a claim. 842.103 Section 842.103 National... CLAIMS Claims Under the National Guard Claims Act (32 U.S.C. 715) § 842.103 Filing a claim. This paragraph explains how to file a claim under the National Guard Claims Act. (a) How and when filed. A claim...

  1. 32 CFR 842.103 - Filing a claim.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Filing a claim. 842.103 Section 842.103 National... CLAIMS Claims Under the National Guard Claims Act (32 U.S.C. 715) § 842.103 Filing a claim. This paragraph explains how to file a claim under the National Guard Claims Act. (a) How and when filed. A claim...

  2. 75 FR 65495 - National Institute of Dental and Craniofacial Research; Interagency Pain Research Coordinating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Dental and Craniofacial Research; Interagency Pain Research Coordinating Committee; Call for Nominations The... curriculum vitae or resume. Dated: October 18, 2010. Amy Adams, National Institute of Dental and Craniofacial...

  3. 75 FR 79025 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--National Shipbuilding Research Program Notice is hereby given that, on November 29....C. 4301 et seq. (``the Act''), National Shipbuilding Research Program (``NSRP'') has filed written...

  4. 75 FR 65511 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--National Shipbuilding Research Program Notice is hereby given that, on September 20....C. 4301 et seq. (``the Act''), National Shipbuilding Research Program (``NSRP'') has filed written...

  5. The world`s first 27 T and 30 T resistive magnets

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bird, M.D.; Bole, S.; Eyssa, Y.M.

    1996-07-01

    The authors describe in detail a 30 Tesla, 32mm warm bore,m 15 MW resistive magnet which was put into operation at the National High Magnetic Field Laboratory in Tallahassee, FL in March 1995. The magnet consists of three concentric axially-cooled Bitter stacks connected electrically in series. This magnet employs a substantial new development in Bitter magnet technology which allows high current densities without the usually accompanying high stresses. Details of magnet optimization, design, construction, testing and operation are presented. The authors also report on operating experience with the 27 T magnets.

  6. 34 CFR 660.32 - What additional selection criteria does the Secretary use for an application for a research...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... use for an application for a research project, a survey, or a study? 660.32 Section 660.32 Education... evaluates an application for a research project, study, or survey on the basis of the criteria in this..., DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM How Does the Secretary Make a Grant...

  7. 34 CFR 660.32 - What additional selection criteria does the Secretary use for an application for a research...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... use for an application for a research project, a survey, or a study? 660.32 Section 660.32 Education... evaluates an application for a research project, study, or survey on the basis of the criteria in this..., DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM How Does the Secretary Make a Grant...

  8. 34 CFR 660.32 - What additional selection criteria does the Secretary use for an application for a research...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... use for an application for a research project, a survey, or a study? 660.32 Section 660.32 Education... evaluates an application for a research project, study, or survey on the basis of the criteria in this..., DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM How Does the Secretary Make a Grant...

  9. 34 CFR 660.32 - What additional selection criteria does the Secretary use for an application for a research...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... use for an application for a research project, a survey, or a study? 660.32 Section 660.32 Education... evaluates an application for a research project, study, or survey on the basis of the criteria in this..., DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM How Does the Secretary Make a Grant...

  10. 34 CFR 660.32 - What additional selection criteria does the Secretary use for an application for a research...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... use for an application for a research project, a survey, or a study? 660.32 Section 660.32 Education... evaluates an application for a research project, study, or survey on the basis of the criteria in this..., DEPARTMENT OF EDUCATION THE INTERNATIONAL RESEARCH AND STUDIES PROGRAM How Does the Secretary Make a Grant...

  11. 21 CFR 1301.32 - Action on applications for research in Schedule I substances.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Action on applications for research in Schedule I... REGISTRATION OF MANUFACTURERS, DISTRIBUTORS, AND DISPENSERS OF CONTROLLED SUBSTANCES Action on Application for Registration: Revocation Or Suspension of Registration § 1301.32 Action on applications for research in...

  12. 45 CFR 1170.32 - Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Existing facilities. 1170.32 Section 1170.32 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NONDISCRIMINATION ON THE BASIS OF HANDICAP IN FEDERALLY...

  13. 45 CFR 1170.32 - Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Existing facilities. 1170.32 Section 1170.32 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES NONDISCRIMINATION ON THE BASIS OF HANDICAP IN FEDERALLY...

  14. 32 CFR 2001.60 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false General. 2001.60 Section 2001.60 National Defense Other Regulations Relating to National Defense INFORMATION SECURITY OVERSIGHT OFFICE, NATIONAL ARCHIVES AND RECORDS ADMINISTRATION CLASSIFIED NATIONAL SECURITY INFORMATION Self-Inspections § 2001.60...

  15. 32 CFR 2001.60 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false General. 2001.60 Section 2001.60 National Defense Other Regulations Relating to National Defense INFORMATION SECURITY OVERSIGHT OFFICE, NATIONAL ARCHIVES AND RECORDS ADMINISTRATION CLASSIFIED NATIONAL SECURITY INFORMATION Self-Inspections § 2001.60...

  16. 32 CFR 2001.60 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false General. 2001.60 Section 2001.60 National Defense Other Regulations Relating to National Defense INFORMATION SECURITY OVERSIGHT OFFICE, NATIONAL ARCHIVES AND RECORDS ADMINISTRATION CLASSIFIED NATIONAL SECURITY INFORMATION Self-Inspections § 2001.60...

  17. 32 CFR 2001.60 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false General. 2001.60 Section 2001.60 National Defense Other Regulations Relating to National Defense INFORMATION SECURITY OVERSIGHT OFFICE, NATIONAL ARCHIVES AND RECORDS ADMINISTRATION CLASSIFIED NATIONAL SECURITY INFORMATION Self-Inspections § 2001.60...

  18. The Three-Dimensional Structure of HH 32 from GMOS IFU Spectroscopy

    NASA Astrophysics Data System (ADS)

    Beck, Tracy L.; Riera, A.; Raga, A. C.; Aspin, C.

    2004-01-01

    We present new high-resolution spectroscopic observations of the Herbig-Haro object HH 32 from system verification observations made with the GMOS IFU at Gemini North Observatory. The three-dimensional spectral data cover a 8.7"×5.85" spatial field and 4820-7040 Å spectral region centered on the HH 32 A knot complex. We show the position-dependent line profiles and radial velocity channel maps of the Hα line, as well as line ratio velocity channel maps of [O III] λ5007/Hα, [O I] λ6300/Hα, [N II] λ6583/Hα, [S II] λλ(6716+6730)/Hα, and [S II] λ6716/λ6730. We find that the line emission and the line ratios vary significantly on spatial scales of ~1" and over velocities of ~50 km s-1. A ``3/2-dimensional'' bow shock model is qualitatively successful at reproducing the general features of the radial velocity channel maps, but it does not show the same complexity as the data, and it fails to reproduce the line ratios in our high spatial resolution maps. The observations of HH 32 A show two or three superposed bow shocks with separations of ~3", which we interpret as evidence of a line-of-sight superposition of two or three working surfaces located along the redshifted body of the HH 32 outflow. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the National Science Foundation on behalf of the Gemini partnership: the NSF, the Particle Physics and Astronomy Research Council (United Kingdom), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), CNPq (Brazil), and CONICET (Argentina).

  19. National Research Council Experts – October 2014

    EPA Pesticide Factsheets

    Today, EPA announced that the Integrated Risk Information System (IRIS) Program’s Bimonthly Public Science meetings will be supplemented with independent scientific experts identified by the National Academies’ National Research Council (NRC).

  20. IRIS and the National Research Council (NRC)

    EPA Pesticide Factsheets

    Since the 2011 National Academies’ National Research Council (NRC) review of the IRIS Program's assessment of Formaldehyde, EPA and NRC have had an ongoing relationship into the improvements of developing the IRIS Assessments.

  1. Federal Research and Development Funding: FY2011

    DTIC Science & Technology

    2010-12-07

    sequencing and analysis of 300 autism spectrum disorder cases. In support of the National Nanotechnology Initiative, NIH is requesting an increase of...research portfolio, covering the spectrum from basic viral research to vaccine development trials, would increase 3.2% to about $3.2 billion in FY2011...highlighted examples of research in cancer, heart disease, and autism , particularly over $1 billion in research applying the technology produced by the

  2. 32 CFR 16.3 - Available sentences.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Available sentences. 16.3 Section 16.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING § 16.3 Available sentences. (a) General. 32 CFR part 9 permits a military commission wide latitude in sentencing...

  3. 32 CFR 16.4 - Sentencing procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Sentencing procedures. 16.4 Section 16.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING... relevant to sentencing. 32 CFR 9.6(e)(10) permits the Prosecution and Defense to present information to aid...

  4. 32 CFR 16.4 - Sentencing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Sentencing procedures. 16.4 Section 16.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING... relevant to sentencing. 32 CFR 9.6(e)(10) permits the Prosecution and Defense to present information to aid...

  5. 32 CFR 16.3 - Available sentences.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Available sentences. 16.3 Section 16.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING § 16.3 Available sentences. (a) General. 32 CFR part 9 permits a military commission wide latitude in sentencing...

  6. 32 CFR 16.4 - Sentencing procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Sentencing procedures. 16.4 Section 16.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING... relevant to sentencing. 32 CFR 9.6(e)(10) permits the Prosecution and Defense to present information to aid...

  7. 32 CFR 16.3 - Available sentences.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Available sentences. 16.3 Section 16.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING § 16.3 Available sentences. (a) General. 32 CFR part 9 permits a military commission wide latitude in sentencing...

  8. 32 CFR 16.3 - Available sentences.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Available sentences. 16.3 Section 16.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING § 16.3 Available sentences. (a) General. 32 CFR part 9 permits a military commission wide latitude in sentencing...

  9. 32 CFR 16.4 - Sentencing procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Sentencing procedures. 16.4 Section 16.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS SENTENCING... relevant to sentencing. 32 CFR 9.6(e)(10) permits the Prosecution and Defense to present information to aid...

  10. 32 CFR 285.5 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Information requirements. 285.5 Section 285.5 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM... requirements. Reporting requirements are in DoD 32 CFR part 286 and have been assigned Report Control Symbol DD...

  11. 32 CFR 285.5 - Information requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Information requirements. 285.5 Section 285.5 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM... requirements. Reporting requirements are in DoD 32 CFR part 286 and have been assigned Report Control Symbol DD...

  12. Outreach activities in support of the Missouri S&T national UTC.

    DOT National Transportation Integrated Search

    2010-02-01

    This report describes a comprehensive initiative providing outreach for the Missouri University of Science and Technology (Missouri S&T) National University Transportation Center (NUTC). The goal of this comprehensive outreach program was to provide ...

  13. 15 CFR 265.32 - Trespassing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

  14. 15 CFR 265.32 - Trespassing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

  15. 15 CFR 265.32 - Trespassing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

  16. 15 CFR 265.32 - Trespassing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

  17. 15 CFR 265.32 - Trespassing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Trespassing. 265.32 Section 265.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF..., GAITHERSBURG, MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Buildings and Grounds § 265.32 Trespassing. No...

  18. Conceptual design of a 24-32 MW radially-cooled insert for a greater than or = 45 T hybrid system

    NASA Astrophysics Data System (ADS)

    Weggel, Robert J.; Hake, Michael E.; Stejskal, Vladimir

    1994-07-01

    The FBNML is designing and will fabricate a radially-cooled insert magnet to generate 70% of the field of a system, Hybrid V, to surpass 45 T in a 32 mm bore. The insert is to have an overall diameter and a maximum active coil length of 610 mm. With a background field of 14 T the system should generate 47 T at 24 MW and nearly 49 T at 32 MW. The peak stress is extremely high, calling for conductors such as Be-Cu (UNS C17510) and 24% Ag-Cu with strengths up to 1100 MPa. The peak heat flux density also is high, nearly 12 W/mm(exp 2). Because the water is coldest and its velocity highest where the heat flux is highest, however, the peak temperature is only 80 C. The water flow is approximately = 200 l/s at 27 atm. The system is to be very user friendly. Access is completely unobstructed at the top. Insert removal leaves the plumbing and electrical connections intact. The massive and expensive outer coils should be long lived, the inner coil easily replaceable. During an inner coil burnout, a sleeve intercepts arcing from the inner coil to the middle one, reducing burnout severity and fault loads. The insert should be a worthy successor to those of the FBNML's world-record holding systems, Hybrids II and III.

  19. Clinical Research Nursing: A Critical Resource in the National Research Enterprise

    PubMed Central

    Hastings, Clare E.; Fisher, Cheryl A.; McCabe, Margaret A.

    2012-01-01

    Translational clinical research has emerged as an important priority for the national research enterprise, with a clearly stated mandate to deliver prevention strategies, treatments and cures based on scientific innovations faster to the public. Within this national effort, a lack of consensus persists concerning the need for clinical nurses with expertise and specialized training in study implementation and the delivery of care to research participants. This paper reviews efforts to define and document the role of practicing nurses in implementing studies and coordinating clinical research in a variety of clinical settings and differentiates this clinical role from the role of nurses as scientists and principal investigators. We propose an agenda for building evidence that having nurses provide and coordinate study treatments and procedures can potentially improve research efficiency, participant safety, and the quality of research data. We also provide recommendations for the development of the emerging specialty of clinical research nursing. PMID:22172370

  20. Mobile robotics research at Sandia National Laboratories

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Morse, W.D.

    Sandia is a National Security Laboratory providing scientific and engineering solutions to meet national needs for both government and industry. As part of this mission, the Intelligent Systems and Robotics Center conducts research and development in robotics and intelligent machine technologies. An overview of Sandia`s mobile robotics research is provided. Recent achievements and future directions in the areas of coordinated mobile manipulation, small smart machines, world modeling, and special application robots are presented.

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