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1

Evaluation of common anesthetic and analgesic techniques for tail biopsy in mice.  

PubMed

Tail biopsy in mice is a common procedure in genetically modified mouse colonies. We evaluated the anesthetic and analgesic effects of various agents commonly used to mitigate pain after tail biopsy. We used a hot-water immersion assay to evaluate the analgesic effects of isoflurane, ice-cold ethanol, ethyl chloride, buprenorphine, and 2-point local nerve blocks before studying their effects on mice receiving tail biopsies. Mice treated with ethyl chloride spray, isoflurane and buprenorphine, and 2-point local nerve blocks demonstrated increased tail-flick latency compared with that of untreated mice. When we evaluated the behavior of adult and preweanling mice after tail biopsy, untreated mice demonstrated behavioral changes immediately after tail biopsy that lasted 30 to 60 min before returning to normal. The use of isoflurane, isoflurane and buprenorphine, buprenorphine, 2-point nerve block, or ethyl chloride spray in adult mice did not significantly improve their behavioral response to tail biopsy. Similarly, the use of buprenorphine and ethyl chloride spray in preweanling mice did not improve their behavioral response to tail biopsy compared with that of the untreated group. However, immersion in bupivacaine for 30 s after tail biopsy decreased tail grooming behavior during the first 30 min after tail biopsy. The anesthetic and analgesic regimens tested provide little benefit in adult and preweanling mice. Given that tail biopsy results in pain that lasts 30 to 60 min, investigators should carefully consider the appropriate anesthetic or analgesic regimen to incorporate into tail-biopsy procedures for mice. PMID:23294888

Jones, Carissa P; Carver, Scott; Kendall, Lon V

2012-11-01

2

Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy  

Microsoft Academic Search

The usefulness of tonsillar biopsy on live deer for preclinical diagnosis of the transmissible spongiform encephalopathy chronic wasting disease (CWD) was evaluated. Disease was tracked in a CWD-endemic herd using serial tonsillar biopsies collected at 6 to 9 month intervals from 34 captive mule deer (Odocoileus hemionus) and five white-tailed deer (O. virginianus). Tonsillar biopsies were examined for accumulation of

Margaret A. Wild; Terry R. Spraker; Christina J. Sigurdson; Katherine I. O'Rourke; Michael W. Miller

3

Biopsies  

MedlinePLUS

• Overview A biopsy is the removal of tissue in order to examine it for disease. The tissue samples can be taken from any part of the body. Biopsies are performed in several different ways. Some biopsies ...

4

Biopsy  

MedlinePLUS

A biopsy is the removal of a small piece of tissue for laboratory examination. ... There are several different types of biopsies. A needle biopsy is called a percutaneous biopsy. It removes tissue using a hollow tube called a syringe. The needle is passed ...

5

Biopsy  

MedlinePLUS

... Favorite Name: Category: Share: Yes No, Keep Private Biopsy Share | Many medical conditions, not only cases of ... for lab examination. This procedure is called a biopsy, which is preformed by a variety of techniques. ...

6

Biopsy  

MedlinePLUS

... carry only a small risk of bleeding or infection at the biopsy site. For larger open biopsies, there are additional risks that accompany general anesthesia and larger surgical procedures. When To Call a Professional After any ...

7

C-fin: a cultured frog tadpole tail fin biopsy approach for detection of thyroid hormone-disrupting chemicals.  

PubMed

There is a need for the development of a rapid method for identifying chemicals that disrupt thyroid hormone (TH) action while maintaining complex tissue structure and biological variation. Moreover, no assay to date allows a simultaneous screen of an individual's response to multiple chemicals. A cultured tail fin biopsy or C-fin assay was developed using Rana catesbeiana tadpoles. Multiple tail fin biopsies were taken per tadpole, cultured in serum-free medium, and then each biopsy was exposed to a different treatment condition. The effects of known disruptors of TH action were evaluated in the C-fin assay. Chemical exposure was performed +/- 10 nM 3,3',5-triiodothyronine and real-time quantitative polymerase chain reaction (QPCR) of two TH-responsive transcripts, TH receptor beta (TRbeta) and the Rana larval keratin type I (RLKI), was performed. Within 48 h of exposure to Triac (1-100 nM), roscovitine (0.6-60 microM), or genistein (1-100 microM), perturbations in TH signaling were detected. Tetrabromobisphenol A (TBBPA) (10-1,000 nM) showed no effect. Acetochlor (1-100 nM) elicited a modest effect on the TH-dependent induction of TRbeta transcript. These data reveal that a direct tissue effect may not be critical for TBBPA and acetochlor to disrupt TH action previously observed in intact tadpoles. PMID:20821457

Hinther, Ashley; Domanski, Dominik; Vawda, Saadia; Helbing, Caren C

2010-02-01

8

Sex bias in biopsy samples collected from free-ranging dolphins SOPHIE QUROUIL  

E-print Network

1 Sex bias in biopsy samples collected from free-ranging dolphins SOPHIE QU�ROUIL 1,2,* , LUÍS sex ratio has to be inferred indirectly. We used molecular sexing to determine the gender of 340, and common dolphins, Delphinus delphis, collected around the Azores and Madeira. Sex ratio was globally

Paris-Sud XI, Université de

9

Ureteral retrograde brush biopsy  

MedlinePLUS

Biopsy - brush - urinary tract; Retrograde ureteral brush biopsy cytology; Cytology - ureteral retrograde brush biopsy ... to be biopsied is rubbed with the brush. Biopsy forceps may be used instead to collect a ...

10

Congener-specific analysis of polychlorinated biphenyls in white-tailed sea eagles Haliaeetus albicilla collected in Poland  

Microsoft Academic Search

The concentrations of polychlorinated biphenyl (PCBs) congeners including highly toxic non-, mono-, and di-ortho coplanar members as well as their pattern were determined in breast muscles of white-tailed sea eagles collected dead between 1982 and 1990 in Poland. There was a wide variation in total PCB residue concentrations among eagles from various breeding sites, with the Baltic Sea coast registering

J. Falandysz; N. Yamashita; S. Tanabe; R. Tatsukawa; L. Rucifiska; T. Mizera; B. Jakuczun

1994-01-01

11

Kidney Biopsy  

MedlinePLUS

... List of Topics and Titles : Kidney Biopsy Kidney Biopsy On this page: What is a kidney biopsy? ... Research For More Information What is a kidney biopsy? A biopsy is a diagnostic test that involves ...

12

Liver biopsy  

MedlinePLUS

Biopsy - liver; Percutaneous biopsy ... prevent pain or to calm you (sedative). The biopsy may be done through the abdominal wall: You ... provider will find the correct spot for the biopsy needle to be inserted into the liver. This ...

13

Gum biopsy  

MedlinePLUS

Biopsy - gingiva (gums) ... to eat for a few hours before the biopsy. ... Bleeding from the biopsy site Infection of the gums Soreness ... Avoid brushing the area where the biopsy was performed for 1 week.

14

Collection Efficiency and Ice Accretion Characteristics of Two Full Scale and One 1/4 Scale Business Jet Horizontal Tails  

NASA Technical Reports Server (NTRS)

Collection efficiency and ice accretion calculations have been made for a series of business jet horizontal tail configurations using a three-dimensional panel code, an adaptive grid code, and the NASA Glenn LEWICE3D grid based ice accretion code. The horizontal tail models included two full scale wing tips and a 25 percent scale model. Flow solutions for the horizontal tails were generated using the PMARC panel code. Grids used in the ice accretion calculations were generated using the adaptive grid code ICEGRID. The LEWICE3D grid based ice accretion program was used to calculate impingement efficiency and ice shapes. Ice shapes typifying rime and mixed icing conditions were generated for a 30 minute hold condition. All calculations were performed on an SGI Octane computer. The results have been compared to experimental flow and impingement data. In general, the calculated flow and collection efficiencies compared well with experiment, and the ice shapes appeared representative of the rime and mixed icing conditions for which they were calculated.

Bidwell, Colin S.; Papadakis, Michael

2005-01-01

15

Nerve biopsy  

MedlinePLUS

Biopsy - nerve ... A nerve biopsy is most often done on a nerve in the ankle, forearm, or along a rib. The health care ... feel a prick and a mild sting. The biopsy site will be sore for a few days ...

16

Endometrial biopsy  

MedlinePLUS

Biopsy - endometrium ... The biopsy is normal if the cells in the sample are not abnormal. ... Risks of endometrial biopsy include: Infection Causing a hole in (perforating) the uterus or tearing the cervix (rarely occurs) Prolonged bleeding Slight spotting ...

17

Synovial biopsy  

MedlinePLUS

Biopsy - synovial membrane ... fluid in and out of the area. A biopsy grasper is inserted through the trocar and turned ... Synovial biopsy helps diagnose gout , bacterial infections, or other infections. It can be used to diagnose certain autoimmune disorders, ...

18

Biopsy - polyps  

MedlinePLUS

Polyp biopsy ... are treated is the colon. How a polyp biopsy is taken depends on the location: Colonoscopy or flexible sigmoidoscopy explores the large bowel Colposcopy-directed biopsy examines the vagina and cervix Esophagogastroduodenoscopy (EGD) or ...

19

Myocardial biopsy  

MedlinePLUS

Heart biopsy; Biopsy - heart ... from the right or left side of the heart. If the biopsy is done without another procedure, ... the neck and then carefully threaded into the heart. The doctor uses moving x-ray images (fluoroscopy) ...

20

Differential clustering of bowel biopsy-associated bacterial profiles of specimens collected in Mexico and Canada: what do these profiles represent?  

PubMed

Bowel commensals appear to be an important source of antigens that drive the chronic immune inflammation characteristic of Crohn's disease and ulcerative colitis [inflammatory bowel diseases (IBD)]. Biopsy-associated bacteria are assumed to be particularly relevant in bacteriological investigations of IBD because they are assumed to be located on the mucosal surface and hence close to immunological cells. This investigation analysed the bacterial collections associated with bowel biopsies, aspirates of residual fluid after bowel cleansing and faeces from IBD patients and non-IBD subjects in Edmonton, Canada, and Mexico City, Mexico. Temporal temperature gradient gel electrophoresis of 16S rRNA gene sequences produced profiles of the bacterial collections and their similarities were compared. Similarity analysis showed that the profiles did not cluster according to disease status, but that Canadian and Mexican profiles could be differentiated by this method. Comparison of biopsy, aspirate and faecal samples obtained from the same subject showed that, on average, the profiles were highly similar. Therefore, biopsy-associated bacteria are likely to represent, at least in part, contaminants from the fluid, which resembles a faecal solution, that pools in the bowel after cleansing prior to endoscopy. PMID:18065676

Bibiloni, Rodrigo; Tandon, Puneeta; Vargas-Voracka, Florencia; Barreto-Zuniga, Raphael; Lupian-Sanchez, Andres; Rico-Hinojosa, Miguel Angel; Guban, Jennifer; Fedorak, Richard; Tannock, Gerald W

2008-01-01

21

Liver Biopsy  

MedlinePLUS

A liver biopsy is a medical procedure performed in order to obtain a small sample of the liver. This is accomplished ... scar. The most common reasons for a liver biopsy include the evaluation of: ? Jaundice ? Liver inflammation (hepatitis) ? ...

22

Skin Biopsy  

MedlinePLUS

What Is a Skin Biopsy and Who Would Need One? In a biopsy, a doctor or surgeon takes a sample of a lump, a sore, ... exactly what it is. Doctors may order skin biopsies to help diagnose or monitor possible health problems ...

23

Skin Biopsy  

MedlinePLUS

newsletter | contact Share | Biopsy, Skin A A A Using a small tool similar to an apple corer, a punch biopsy can be used to remove a small area ... for review and diagnosis. Procedure Overview A skin biopsy, where a physician removes a small sample of ...

24

Borrelia burgdorferi not detected in widespread Ixodes scapularis (Acari: Ixodidae) collected from white-tailed deer in Tennessee.  

PubMed

Lyme disease (LD), caused by the bacterium Borrelia burgdorferi and transmitted in the eastern United States by blacklegged ticks, Ixodes scapularis Say, is classified as nonendemic in Tennessee and surrounding states in the Southeast. Low incidence of LD in these states has been attributed, in part, to vector ticks being scarce or absent; however, tick survey data for many counties are incomplete or out of date. To improve our knowledge of the distribution, abundance, and Borrelia spp. prevalence of I. scapularis, we collected ticks from 1,018 hunter-harvested white-tailed deer (Odocoileus virginianus (Zimmerman)) from 71 of 95 Tennessee counties in fall 2007 and 2008. In total, 160 deer (15.7%) from 35 counties were infested with adult I. scapularis; 30 of these counties were new distributional records for this tick. The mean number of I. scapularis collected per infested deer was 5.4 +/- 0.6 SE. Of the 883 I. scapularis we removed from deer, none were positive for B. burgdorferi and one tested positive for B. miyamotoi. Deer are not reservoir hosts for B. burgdorferi; nevertheless, past surveys in northern LD-endemic states have readily detected B. burgdoreferi in ticks collected from deer. We conclude that I. scapularis is far more widespread in Tennessee than previously reported. The absence of detectable B. burgdorferi infection among these ticks suggests that the LD risk posed by I. scapularis in the surveyed areas of Tennessee is much lower than in LD-endemic areas of the Northeast and upper Midwest. PMID:23270178

Rosen, M E; Hamer, S A; Gerhardt, R R; Jones, C J; Muller, L I; Scott, M C; Hickling, G J

2012-11-01

25

Bone Biopsy  

MedlinePLUS

• Overview A bone biopsy is an image-guided procedure in which a small sample of a bone is removed from the body and ... is often called a closed or needle bone biopsy , because it involves inserting a needle directly into ...

26

Liver Biopsy  

MedlinePLUS

... dye, called contrast medium. CT scans require the person to lie on a table that slides into a tunnel- ... bandage over the incision After the biopsy, the person must lie on his or her right side for up ...

27

Total and methylmercury in soft tissues of white-tailed eagle (Haliaeetus albicilla) and Osprey (Pandion haliaetus) collected in Poland.  

PubMed

Mercury (Hg) contamination in piscivorous birds, especially methylmercury (MeHg), has been drawing much attention worldwide in regard to its bioaccumulation and biomagnification in food chains. In this study on Hg in the soft tissues of white-tailed eagles (n = 22) and ospreys (n = 2) from Poland, total Hg (THg) range was 0.15-47.6 while MeHg range was 0.11-8.05 mg kg?¹ dry weight. In both species, median THg and MeHg concentrations were lower in the muscle and brain than in the liver and kidney. Median nephric residues were just under 3 and 5 mgTHg kg?¹ or 0.9 and 3.7 mgMeHg kg?¹ for white-tailed eagle and osprey, respectively. In Norwegian data from the 1970s and in our results, MeHg in the muscle of white-tailed eagle was ~60 % THg (%MeHg = MeHg/THg × 100), lower than in other piscivorous birds. A clear similarity in THg tissue levels was found between Polish and German populations of white-tailed eagles. PMID:24870933

Kalisinska, Elzbieta; Gorecki, Jerzy; Lanocha, Natalia; Okonska, Anna; Melgarejo, Javier B; Budis, Halina; Rzad, Izabella; Golas, Jerzy

2014-11-01

28

Lymph node biopsy  

MedlinePLUS

Biopsy - lymph nodes; Open lymph node biopsy; Fine needle aspiration biopsy; Sentinel lymph node biopsy ... A lymph node biopsy is done in an operating room in a hospital. Or, it is done at an outpatient surgical center. The ...

29

Biopsy: What to Expect  

MedlinePLUS

Excisional biopsy : Commonly used to remove a tumor suspected to be skin cancer, an excisional biopsy consists of removing ... flap are needed to treat the wound. Incisional biopsy : During this biopsy, only a portion of the ...

30

Bone lesion biopsy  

MedlinePLUS

Bone biopsy; Biopsy - bone ... A special drill needle is usually used. The biopsy needle is pushed and twisted into the bone. ... are applied, and covered with a bandage. Bone biopsy may also be done under general anesthesia to ...

31

Nasal mucosal biopsy  

MedlinePLUS

Biopsy - nasal mucosa; Nose biopsy ... to fast for a few hours before the biopsy. ... Nasal mucosal biopsy is usually done when abnormal tissue is seen during examination of the nose. It may also be done ...

32

Design of collective Thomson scattering system using 77 GHz gyrotron for bulk and tail ion diagnostics in the large helical device  

SciTech Connect

Collective Thomson scattering (CTS) system is expected to be a strong diagnostic tool for measuring thermal and fast ion distribution function at a local point inside plasmas. The electron cyclotron resonance heating system using a gyrotron at the frequency range of 77 GHz has been installed at the large helical device (LHD). The feasibility of CTS system using the 77 GHz gyrotron is assessed in terms of scattering spectrum and a background noise of the electron cyclotron emission, which affect the signal to noise ratio, with the realistic plasma parameters and incident port locations of LHD. Based on the calculated scattering spectra for bulk and tail fast ion diagnostics, the scattering radiation receiver system with gyrotron frequency feedback circuit is proposed to avoid the frequency chirping.

Nishiura, M.; Tanaka, K.; Kubo, S.; Kawahata, K.; Shimozuma, T.; Mutoh, T. [National Institute for Fusion Science, 322-6 Oroshi, Toki, Gifu 509-5292 (Japan); Saito, T.; Tatematsu, Y.; Notake, T. [Research Center for Development of Far-Infrared Region, University of Fukui, 3-9-1 Bunkyo, Fukui 910-8507 (Japan)

2008-10-15

33

Muscle biopsy (image)  

MedlinePLUS

A muscle biopsy involves removal of a plug of tissue usually by a needle to be later used for examination. Sometimes ... there is a patchy condition expected an open biopsy may be used. Open biopsy involves a small ...

34

Bone biopsy (image)  

MedlinePLUS

A bone biopsy is performed by making a small incision into the skin. A biopsy needle retrieves a sample of bone and it ... examination. The most common reasons for bone lesion biopsy are to distinguish between benign and malignant bone ...

35

Breast biopsy - ultrasound  

MedlinePLUS

Biopsy - breast - ultrasound; Ultrasound-guided breast biopsy; Core needle breast biopsy - ultrasound ... care provider first cleans the area on your breast, and injects a numbing medicine. The doctor makes ...

36

PanMetaDocs - A tool for collecting and managing the long tail of "small science data"  

NASA Astrophysics Data System (ADS)

In the early days of thinking about cyberinfrastructure the focus was on "big science data". Today, the challenge is not anymore to store several terabytes of data, but to manage data objects in a way that facilitates their re-use. Key to re-use by a user as a data consumer is proper documentation of the data. Also, data consumers need discovery metadata to find the data they need and they need descriptive metadata to be able to use the data they retrieved. Thus, data documentation faces the challenge to extensively and completely describe these objects, hold the items easily accessible at a sustainable cost level. However, data curation and documentation do not rank high in the everyday work of a scientist as a data producer. Data producers are often frustrated by being asked to provide metadata on their data over and over again, information that seemed very obvious from the context of their work. A challenge to data archives is the wide variety of metadata schemata in use, which creates a number of maintenance and design challenges of its own. PanMetaDocs addresses these issues by allowing an uploaded files to be described by more than one metadata object. PanMetaDocs, which was developed from PanMetaWorks, is a PHP based web application that allow to describe data with any xml-based metadata schema. Its user interface is browser based and was developed to collect metadata and data in collaborative scientific projects situated at one or more institutions. The metadata fields can be filled with static or dynamic content to reduce the number of fields that require manual entries to a minimum and make use of contextual information in a project setting. In the development of PanMetaDocs the business logic of panMetaWorks is reused, except for the authentication and data management functions of PanMetaWorks, which are delegated to the eSciDoc framework. The eSciDoc repository framework is designed as a service oriented architecture that can be controlled through a REST interface to create version controlled items with metadata records in XML format. PanMetaDocs utilizes the eSciDoc items model to add multiple metadata records that describe uploaded files in different metadata schemata. While datasets are collected and described, shared to collaborate with other scientists and finally published, data objects are transferred from a shared data curation domain into a persistent data curation domain. Through an RSS interface for recent datasets PanMetaWorks allows project members to be informed about data uploaded by other project members. The implementation of the OAI-PMH interface can be used to syndicate data catalogs to research data portals, such as the panFMP data portal framework. Once data objects are uploaded to the eSciDoc infrastructure it is possible to drop the software instance that was used for collecting the data, while the compiled data and metadata are accessible for other authorized applications through the institution's eSciDoc middleware. This approach of "expendable data curation tools" allows for a significant reduction in costs for software maintenance as expensive data capture applications do not need to be maintained indefinitely to ensure long term access to the stored data.

Klump, J.; Ulbricht, D.

2011-12-01

37

Dermatology procedures: skin biopsy.  

PubMed

The procedures used most often for office-based skin biopsies are two types of shave biopsies, punch biopsy, and elliptical biopsy performed with a scalpel. Tangential shave biopsy is superficial and best suited to small, raised, benign lesions. Saucerization shave biopsy is deeper and is used for excisional biopsy of atypical nevi, for squamous and basal cell carcinomas, and as initial biopsy for suspected melanoma. Punch biopsy also removes deeper tissue and can be used to excise or sample a variety of lesions, including pigmented nevi. Elliptical biopsy using a scalpel is reserved for larger lesions not amenable to shave or punch biopsies. It is not necessary to discontinue anticoagulants before office-based skin biopsy is performed or to administer topical or systemic antibiotics. When sutures are used for wound closure, it is important for the sutures to have appropriate tensile strength. Multifilament sutures should be avoided in areas prone to infection, such as the feet. An important complication of skin biopsy is the development of hypertrophic and keloid scars, which are more common among patients with dark skin. Injection of triamcinolone or verapamil into a maturing scar can minimize the possibility of hypertrophic and keloid scars. PMID:25373033

Nguyen, Tam

2014-11-01

38

Bone marrow biopsy  

MedlinePLUS

Biopsy - bone marrow ... A bone marrow biopsy may be done in the health care provider's office or in a hospital. The sample may be taken from the pelvic or breast bone. Sometimes, other areas are used. Marrow is removed ...

39

Utilization Trends and Positive Biopsy Rates for Prostate Biopsies in the United States: 2005 to 2011  

PubMed Central

This article assesses the positive biopsy rate and core sampling pattern in patients undergoing needle biopsy of the prostate in the United States at a national reference laboratory (NRL) and anatomic pathology laboratories integrated into urology group practices, and analyzes the relationship between positive biopsy rates and the number of specimen vials per biopsy. For the years 2005 to 2011 we collected pathology data from an NRL, including number of urologists and urology practices referring samples, total specimen vials submitted for prostate biopsies, and final pathologic diagnosis for each case. The diagnoses were categorized as benign, malignant, prostatic intraepithelial neoplasia, or atypical small acinar proliferation. Over the same period, similar data were gathered from urology practices with in-house laboratories performing global pathology services (urology practice laboratories; UPLs) as identified by a survey of members of the Large Urology Group Practice Association. For each year studied, positive biopsy rate and number of specimen vials per biopsy were calculated in aggregate and separately for each site of service. From 2005 to 2011, 437,937 biopsies were submitted in > 4.23 million vials (9.4 specimen vials/biopsy); overall positive biopsy rate was 40.3%-this was identical at both the NRL and UPL (P = .97). Nationally, the number of specimen vials per biopsy increased sharply from a mean of 8.8 during 2005 to 2008 to a mean of 10.3 from 2009 to 2011 (difference, 1.5 specimen vials/biopsy; P = .03). For the most recent 3-year period (2009–2011), the difference of 0.6 specimen vials per biopsy between the NRL (10.0) and UPL (10.6) was not significant (P = 0.08). Positive biopsy rate correlated strongly (P < .01) with number of specimen vials per biopsy. The positive prostate biopsy rate is 40.3% and is identical across sites of service. Although there was a national trend toward increased specimen vials per biopsy from 2005 to 2011, from 2009 to 2011 there was no significant difference in specimen vials per biopsy across sites of service. Increased cancer detection rate correlated significantly with increased number of specimens examined. Segregation of prostate biopsy cores into 10 to 12 unique specimen vials has been widely adopted by urologists across sites of service. PMID:24659910

Kapoor, Deepak A; Bostwick, David G; Mendrinos, Savvas E; Anderson, Ann E; Olsson, Carl A

2013-01-01

40

Utility of synovial biopsy  

PubMed Central

Synovial biopsies, gained either by blind needle biopsy or minimally invasive arthroscopy, offer additional information in certain clinical situations where routine assessment has not permitted a certain diagnosis. In research settings, synovial histology and modern applications of molecular biology increase our insight into pathogenesis and enable responses to treatment with new therapeutic agents to be assessed directly at the pathophysiological level. This review focuses on the diagnostic usefulness of synovial biopsies in the light of actual developments. PMID:19951395

2009-01-01

41

Biopsy (For Parents)  

MedlinePLUS

What It Is A biopsy is a test that's performed to examine tissue or cells from a part of the body. It can be done ... tissue with a needle and syringe. Sometimes, needle biopsies are done in a radiology department so the ...

42

Breast Lumps - Biopsy  

MedlinePLUS Videos and Cool Tools

... by breast lumps. Breast lumps may be cancerous. Breast cancer occurs in approximately one in every 8 to 9 women. Your doctor may have recommended a biopsy to determine if your lump is cancerous or not. The decision whether or not to have a breast biopsy is also yours. This reference summary will ...

43

Sentinel Lymph Node Biopsy  

Cancer.gov

A fact sheet that describes the sentinel lymph node biopsy (SLNB) procedure, its use in determining the extent, or stage, of cancer in the body, and the results of research on the use of SLNB in breast cancer and melanoma.

44

Lung needle biopsy  

MedlinePLUS

... site. Once bleeding has stopped, a bandage is applied. A chest x-ray is taken immediately after the biopsy. The procedure usually takes 30 - 60 minutes. Laboratory analysis usually takes a few days.

45

Breast Biopsy System  

NASA Technical Reports Server (NTRS)

Charge Coupled Devices (CCDs) are high technology silicon chips that connect light directly into electronic or digital images, which can be manipulated or enhanced by computers. When Goddard Space Flight Center (GSFC) scientists realized that existing CCD technology could not meet scientific requirements for the Hubble Space Telescope Imagining Spectrograph, GSFC contracted with Scientific Imaging Technologies, Inc. (SITe) to develop an advanced CCD. SITe then applied many of the NASA-driven enhancements to the manufacture of CCDs for digital mammography. The resulting device images breast tissue more clearly and efficiently. The LORAD Stereo Guide Breast Biopsy system incorporates SITe's CCD as part of a digital camera system that is replacing surgical biopsy in many cases. Known as stereotactic needle biopsy, it is performed under local anesthesia with a needle and saves women time, pain, scarring, radiation exposure and money.

1994-01-01

46

Color optical biopsy  

NASA Astrophysics Data System (ADS)

Progress has been made towards the development of a flexible true color holographic imaging device for direct optical biopsy. This can potentially be used for surgical techniques employing direct visualization, including endoscopy and laparoscopy. A novel panchromatic `ultrahigh precision' recording media, with a thin layer of ultrafine grain of silver halide crystals of 10-20 nm average diameter, has been utilized. The significance of the development so far, has been the ability to emulate `color optical biopsy' providing useful information of `medical relevance'.

Osanlou, Ardieshir; Bjelkhagen, Hans I.; Snashall, Emma; Osanlou, Orod; Osanlou, Rostam

2014-02-01

47

Proteomic Analysis of Vitreous Biopsy Techniques  

PubMed Central

Purpose To compare vitreous biopsy methods using analysis platforms employed in proteomics biomarker discovery. Methods Vitreous biopsies from 10 eyes were collected sequentially using a 23-gauge needle and a 23-gauge vitreous cutter instrument. Paired specimens were evaluated by UV absorbance spectroscopy, SDS-PAGE, and mass-spectrometry (LC-MS/MS). Results The total protein concentration obtained with a needle and vitrectomy instrument biopsy averaged 1.10 mg/ml (SEM = 0.35) and 1.13 mg/ml (SEM = 0.25), respectively. In eight eyes with low or medium viscidity, there was a very high correlation (R2 = 0.934) between the biopsy methods. When data from two eyes with high viscidity vitreous were included, the correlation was reduced (R2 = 0.704). The molecular weight protein SDS-PAGE profiles of paired needle and vitreous cutter samples were similar, except for a minority of pairs with single band intensity variance. Using LC-MS/MS, equivalent peptides were identified with similar frequencies (R2 ? 0.90) in paired samples. Conclusion Proteins and peptides collected from vitreous needle biopsies are nearly equivalent to those obtained from a vitreous cutter instrument. This study suggests both techniques may be used for most proteomic and biomarker discovery studies of vitreoretinal diseases, although a minority of proteins and peptides may differ in concentration. PMID:23095728

Skeie, Jessica M.; Brown, Eric N.; Martinez, Harryl D.; Russell, Stephen R.; Birkholz, Emily S.; Folk, James C.; Boldt, H. Culver; Gehrs, Karen M.; Stone, Edwin M.; Wright, Michael E.; Mahajan, Vinit B.

2013-01-01

48

Needle Biopsy of the Lung  

MedlinePLUS

Needle Biopsy of the Lung • Overview A lung nodule is relatively round lesion, or area of abnormal tissue located ... is benign (non-cancerous) or cancerous. A needle biopsy, also called a needle aspiration , involves removing some ...

49

Aspiration and Biopsy: Bone Marrow  

MedlinePLUS

KidsHealth > Teens > Cancer Center > Diagnostic Tests > Aspiration and Biopsy: Bone Marrow Print A A A Text Size ... Questions What It Is Bone marrow aspirations and biopsies are performed to examine bone marrow, the spongy ...

50

Sentinel Lymph Node (SLN) Biopsy  

MedlinePLUS

... 1 BREAST CANCER LUMPECTOMY AND SENTINEL LYMPH NODE BIOPSY GENESIS MEDICAL CENTER DAVENPORT, IOWA October 10. 2007 ... breast cancer lumpectomy and subsequent sentinel lymph node biopsy. The procedure will be performed by Dr. David ...

51

Bone Marrow Aspiration and Biopsy  

MedlinePLUS

... be limited. Search Help? Bone Marrow Aspiration and Biopsy Share this page: Was this page helpful? Also ... anesthesia for a bone marrow aspiration and/or biopsy? While you will be given a local anesthetic, ...

52

Aspiration and Biopsy: Bone Marrow  

MedlinePLUS

... Parents > Doctors & Hospitals > Medical Tests & Exams > Aspiration and Biopsy: Bone Marrow Print A A A Text Size ... Questions What It Is Bone marrow aspirations and biopsies are performed to examine bone marrow, the spongy ...

53

Stereotactic (Mammographically Guided) Breast Biopsy  

MedlinePLUS

Stereotactic Breast Biopsy • Overview Lumps or abnormalities in the breast are often detected by physical examination, mammography, or other imaging studies. ... a growth is benign or cancerous. A breast biopsy is performed to remove some cells—either surgically ...

54

Ultrasound-Guided Breast Biopsy  

MedlinePLUS

... the breast are often detected by physical examination, mammography, or other imaging studies. However, it is not ... being performed or the design of the biopsy machine, a biopsy of tissue located deep within the ...

55

Skin biopsy and psoriasis.  

PubMed

A total of 33 skin biopsies were sent to Bangladesh institute of health Science (BIHS) hospital at Mirpur, Dhaka by Consultant skin for histopathological diagnosis between a period of one year and three months. Out of these 33 skin biopsies histopathological diagnosis of psoriasis was made for 13(39.39%), chronic non specific dermatitis (eczema) in 4(12.12%), lichenoid lesion 4(12.12%). Ashy dermatosis 3(9.09%), Nevus 2(6.06%) and corn, hemangioma, prurigo simplex, pityriasis rubra pilaris (PRP), dermatofibroma, 1(3.03%) each. The main presenting feature of these patients were erythematous, prurituc, silvery, scale, plaques or papules for a period between 2 months to 15 years. It is evident from the present study that among different skin lesions sent for histological diagnosis, Psoriasis is common skin pathology in dermatological practice. PMID:20639826

Rahman, M T; Monami, N S; Ferdousi, S; Tahmin, T

2010-07-01

56

Techniques for percutaneous renal biopsies  

Microsoft Academic Search

The technique of renal biopsy includes the preparation of the patient, the localization of the kidneys, the biopsy itself and the postbiopsy care of the patient. A review of the literature and a survey of pediatric nephrologists practicing in the New York metropolitan area and in Philadelphia was used to determine what those techniques were. In preparation for biopsy, bleeding

Bernard G. Gauthier; Robby S. Mahadeo; Howard Trachtman

1993-01-01

57

Open Lung Biopsy  

PubMed Central

Steady improvement in the diagnostic appraisal of obscure pulmonary and mediastinal disease has permitted more intelligent treatment, better prognosis, and where necessary more accurate assessment of compensability. Open lung biopsy is designed to obtain material for pathological study when there is no pleural, mediastinal, or airway lesion on which to base a working diagnosis. A study of 54 patients in whom lung biopsy was performed at the Toronto General Hospital and Weston Sanatorium is reported. A positive tissue diagnosis was obtained in approximately 75%. The procedure is considered relatively innocuous if sensible selection is exercised to exclude patients with terminal disease, particularly that associated with severe cardiorespiratory insufficiency. No major complications occurred in this series. It is concluded that open lung biopsy might reasonably receive much wider application than in the past in cases in which a definite diagnosis cannot otherwise be made. ImagesFig. 1Fig. 2Fig. 3aFig. 3bFig. 4Fig. 5Fig. 6Fig. 7Fig. 8Fig. 9Fig. 10Fig. 11 PMID:14180532

Delarue, Norman C.; Strangway, Donald W.

1964-01-01

58

Human Tail and Myelomeningocele  

Microsoft Academic Search

The human tail is rarely reported and is usually associated with underlying spina bifida occulta. A male newborn presenting a caudal appendage (human tail) with skin-covered myelomeningocele and tethered cord is described. Surgical excision of the human tail and repair of the myelomeningocele were performed 3 days after birth. After the operation, the patient had an uneventful convalescence and received

Pei-Jung Lin; Yu-Tang Chang; Hsing-I Tseng; Jan-You Lin; Yu-Sheng Huang

2007-01-01

59

Tail Density Archimedean and t Copulas Tail Densities of Vines Concluding Remarks Tail Densities of Copulas  

E-print Network

Tail Density Archimedean and t Copulas Tail Densities of Vines Concluding Remarks Tail Densities of Toronto, May 27 2014 Haijun Li Tail Densities of Copulas University of Toronto, May 27 2014 1 / 22 #12;Tail Density Archimedean and t Copulas Tail Densities of Vines Concluding Remarks Let X = (X1

Li, Haijun

60

Transjugular liver biopsy.  

PubMed

Liver biopsy is considered the gold standard for the evaluation of acute and chronic liver disorders. Transjugular liver biopsy (TJLB) was described by Dotter in 1964 and clinically performed for the first time by Hanafee in 1967. TJLB consists of obtaining liver tissue through a rigid cannula introduced into one of the hepatic veins, typically using jugular venous access. The quality of the TJLB specimens has improved so much that the samples obtained by this method are comparable with those obtained with the percutaneous technique. TJLB is indicated for patients with coagulopathy, ascites, peliosis hepatis, morbid obesity, liver transplant, or in patients undergoing a transjugular intrahepatic portosystemic shunt procedure. The technical success rate for a TJLB procedure ranges from 87 to 97%. Sample fragmentation has been reported in 14 to 25% of the TJLB samples. The complication rates are low and range between 1.3% and 6.5%. The purpose of this article is to provide a review of the fundamental aspects of the TJLB procedure, including technique, indications, contraindications, results, and complications. PMID:23729981

Behrens, George; Ferral, Hector

2012-06-01

61

Stereotactic brain biopsy in AIDS  

Microsoft Academic Search

In the hope of finding a treatable condition, the need for rapid diagnosis in HIV-seropositive patients with brain lesions is apparent. In order to evaluate the efficacy of stereotactic brain biopsy in AIDS patients, we retrospectively studied 25 HIV-infected patients undergoing stereotactic biopsy. Brain lesions were identified with gadolinium-enhanced MRI and\\/or contrastCT. Brain biopsy was performed using the system of

Claus Zimmer; Stefanie Miirzheuser; Stephan Patt; Arndt Rolfs; Joachim Gottschalk; Klaus Weigel; George Gosztonyi

1992-01-01

62

Biopsy bag artifact.  

PubMed

We describe a distinctive tissue artifact that results from the use of biopsy bags for processing small impressionable pieces of tissue. In its fully developed form, the artifact produces a tic-tac-toe pattern, while in less pronounced cases it may produce elongated oval spaces in the tissue or a serrated contour at the periphery of the tissue. The artifact was observed in 60% of endometrial specimens, 55% of endocervical curettings, and sporadically in other small specimens. In the endometrial and endocervical specimens, the artifact was focal and did not interfere with the diagnosis. In occasional small lung and prostate specimens, there was focally significant distortion that potentially could compromise the diagnosis. PMID:9704622

Niemann, T H; Tranovich, J G; De Young, B R

1998-08-01

63

Adenocarcinoma associated with tail gut cyst  

PubMed Central

Primary adenocarcinomas of the presacral (retrorectal) space are rare. The diagnosis is usually delayed because of non-specific symptoms, and is made after a biopsy or surgery. These carcinomas arise from cystic lesions developing from remnants of the embryological postanal gut containing mucous-secreting epithelium, known as tail gut cysts. The potential for infection, perianal fistulas and most importantly, malignant change warrants an early complete surgical resection. From an oncologist’s perspective, the management of these carcinomas has varied, and has included adjuvant chemotherapy and/or radiation therapy. We describe here a rare case of adenocarcinoma associated with a tail gut cyst that was discovered incidentally and resected by a posterior approach (Kraske procedure). The patient has had clinical and periodic radiologic surveillance without any evidence of cancer recurrence for over a year and a half. PMID:23450681

Wise, Susannah; Maloney-Patel, Nell; Rezac, Craig; Poplin, Elizabeth

2013-01-01

64

Colonization of mine tailings by marine invertebrates.  

PubMed

An experiment was conducted to determine if a tailings substrate would inhibit recolonization of benthic macrofauna upon closure of a submarine tailings disposal (STD) operation. Trays of defaunated marine sediment, serving as a reference, and trays of tailings from a proposed gold mine were placed at 21 m depth on the ocean floor to allow colonization via settlement from the water column. Trays of reference sediment and tailings, and cores of ambient sediment were collected 9, 17, and 22 months after tray placement. Probable tray effects, which were desirable given the objectives of this study, precluded direct comparison of ecological succession in the tray sediments to the ambient assemblage. The ambient macrofauna assemblage was distinguishable from the reference sediment and tailings assemblages throughout the experiment and displayed more pronounced seasonality. Differences between the reference sediment and tailings assemblages were generally insignificant, including total abundance, total biomass, number of taxa, average size of individuals, numerically dominant taxa, abundance by ecological guilds, and overall community composition. Upon cessation of STD, recolonization of a benthic macrofauna community should not be inhibited by the presence of these tailings as a benthic substrate. PMID:11495492

Kline, E R; Stekoll, M S

2001-05-01

65

Floods from tailings dam failures  

Microsoft Academic Search

This paper compiles the available information on historic tailings dam failures with the purpose to establish simple correlations between tailings ponds geometric parameters (e.g., dam height, tailings volume) and the hydraulic characteristics of floods resulting from released tailings. Following the collapse of a mining waste dam, only a part of tailings and polluted water stored at the dam is released,

M. Rico; G. Benito; A. Díez-Herrero

2008-01-01

66

Transbronchial lung biopsy and pneumothorax.  

PubMed

Mini-interventional procedures are used in the everyday clinical practice by pulmonary physicians and radiologists. Fine needle aspiration and biopsy forceps are the tools mostly used. During these procedures pneumothorax can occur and immediate treatment is necessary. In our current work, we will focus on minimal invasive techniques for biopsy and pneumothorax treatment. PMID:25337401

Huang, Yong; Huang, Haidong; Li, Qiang; Browning, Robert F; Parrish, Scott; Turner, J Francis; Zarogoulidis, Konstantinos; Kougioumtzi, Ioanna; Dryllis, Georgios; Kioumis, Ioannis; Pitsiou, Georgia; Papaiwannou, Antonis; Lampaki, Sofia; Machairiotis, Nikolaos; Katsikogiannis, Nikolaos; Madesis, Athanasios; Karaiskos, Theodoros; Li, Zhigang; Zarogoulidis, Paul

2014-10-01

67

Transbronchial lung biopsy and pneumothorax  

PubMed Central

Mini-interventional procedures are used in the everyday clinical practice by pulmonary physicians and radiologists. Fine needle aspiration and biopsy forceps are the tools mostly used. During these procedures pneumothorax can occur and immediate treatment is necessary. In our current work, we will focus on minimal invasive techniques for biopsy and pneumothorax treatment. PMID:25337401

Huang, Yong; Huang, Haidong; Li, Qiang; Browning, Robert F.; Parrish, Scott; Turner, J. Francis; Zarogoulidis, Konstantinos; Kougioumtzi, Ioanna; Dryllis, Georgios; Kioumis, Ioannis; Pitsiou, Georgia; Papaiwannou, Antonis; Lampaki, Sofia; Machairiotis, Nikolaos; Katsikogiannis, Nikolaos; Madesis, Athanasios; Karaiskos, Theodoros; Li, Zhigang

2014-01-01

68

Helicopter tail rotor noise  

Microsoft Academic Search

A study was made of helicopter tail rotor noise, particularly that due to interactions with the main rotor tip vortices, and with the fuselage separation mean wake. The tail rotor blade-main rotor tip vortex interaction is modelled as an airfoil of infinite span cutting through a moving vortex. The vortex and the geometry information required by the analyses are obtained

S.-T. Chou; A. R. George

1986-01-01

69

Reported tailings dam failures  

Microsoft Academic Search

A detailed search and re-evaluation of the known historical cases of tailings dam failure was carried out. A corpus of 147 cases of worldwide tailings dam disasters, from which 26 located in Europe, was compiled in a database. This contains six sections, including dam location, its physical and constructive characteristics, actual and putative failure cause, sludge hydrodynamics, socio-economical consequences and

M. Rico; G. Benito; A. R. Salgueiro; A. D ´ õez-Herrero; H. G. Pereira

2008-01-01

70

Remote biopsy darting and marking of polar bears  

USGS Publications Warehouse

Remote biopsy darting of polar bears (Ursus maritimus) is less invasive and time intensive than physical capture and is therefore useful when capture is challenging or unsafe. We worked with two manufacturers to develop a combination biopsy and marking dart for use on polar bears. We had an 80% success rate of collecting a tissue sample with a single biopsy dart and collected tissue samples from 143 polar bears on land, in water, and on sea ice. Dye marks ensured that 96% of the bears were not resampled during the same sampling period, and we recovered 96% of the darts fired. Biopsy heads with 5 mm diameters collected an average of 0.12 g of fur, tissue, and subcutaneous adipose tissue, while biopsy heads with 7 mm diameters collected an average of 0.32 g. Tissue samples were 99.3% successful (142 of 143 samples) in providing a genetic and sex identification of individuals. We had a 64% success rate collecting adipose tissue and we successfully examined fatty acid signatures in all adipose samples. Adipose lipid content values were lower compared to values from immobilized or harvested polar bears, indicating that our method was not suitable for quantifying adipose lipid content.

Pagano, Anthony M.; Peacock, Elizabeth; McKinney, Melissa A.

2014-01-01

71

Blood Chemistry of Free-Ranging and Captive White-tailed Deer (Odocoileus virginianus) in Texas  

E-print Network

Blood samples were collected from 602 white-tailed deer (WTD) (Odocoileus virginianus) between October 2008 – October 2009, from 15 different counties throughout Texas. White-tailed deer were evaluated for serum biochemical parameters (total...

Smith, Melanie Love

2012-07-16

72

Pleural needle biopsy  

MedlinePLUS

... a collection of fluid around the lung ( pleural effusion ) or other abnormality of the pleural membrane. Pleural ... Broaddus VC, Light RW. Pleural effusion. In: Mason RJ, Broaddus VC, ... of Respiratory Medicine . 5th ed. Philadelphia, Pa: Elsevier ...

73

Virtual Reality Liver Biopsy Simulator Virtual Reality, Ultrasound-guided Liver Biopsy Simulator  

E-print Network

Virtual Reality Liver Biopsy Simulator Virtual Reality, Ultrasound-guided Liver Biopsy Simulator: Development and Performance Discrimination1 Running head: Virtual Reality Liver Biopsy Simulator Word.1259/bjr/47436030 #12;Virtual Reality Liver Biopsy Simulator ABSTRACT Purpose: Identify and prospectively

Paris-Sud XI, Université de

74

The Tail of BPM  

NASA Astrophysics Data System (ADS)

Business process management suites (BPMS's) represent one of the fastest growing segments in the software industry as organizations automate their key business processes. As this market matures, it is interesting to compare it to Chris Anderson's 'Long Tail.' Although the 2004 "Long Tail" article in Wired magazine was primarily about the media and entertainment industries, it has since been applied (and perhaps misapplied) to other markets. Analysts describe a "Tail of BPM" market that is, perhaps, several times larger than the traditional BPMS product market. This paper will draw comparisons between the concepts in Anderson's article (and subsequent book) and the BPM solutions market.

Kruba, Steve; Meyer, Jim

75

Heads and Tails  

E-print Network

jHeads & tails M. Fae Glasgow Bene Dictum IV An X-Files Slash Zine Bene Dictum IV: Heads & Tails is an amateur publication, copyright ? February 1999 by Oblique Publications. All rights reserved. This copyright is not intended to infringe upon... novellas by Sebastian, Helen Raven, & M. Fae Glasgow) WARNING: THIS ANTHOLOGY CONTAINS SAME-SEX, ADULT-ORIENTED MATERIAL. IT WILL NOT BE SOLD TO ANYONE UNDER THE AGE OF EIGHTEEN. Bene Dictum IV: Heads & Tails an anthology of X-Files slash fiction...

Glasgow, M.F.

1999-01-01

76

Microbiological Characteristics of Acute Prostatitis After Transrectal Prostate Biopsy  

PubMed Central

Purpose We aimed to identify microbiological characteristics in patients with acute prostatitis after transrectal prostate biopsy to provide guidance in the review of prevention and treatment protocols. Materials and Methods A retrospective analysis of medical records was performed in 1,814 cases who underwent prostate biopsy at Seoul St. Mary's Hospital and St. Vincent's Hospital over a 5 year period from 2006 to 2011. Cases in which acute prostatitis occurred within 7 days after the biopsy were investigated. Before starting treatment with antibiotics, sample collections were done for culture of urine and blood. Culture and drug susceptibility was identified by use of a method established by the Clinical and Laboratory Standards Institute. Results A total of 1,814 biopsy procedures were performed in 1,541 patients. For 1,246 patients, the procedure was the first biopsy, whereas for 295 patients it was a repeat biopsy. Twenty-one patients (1.36%) were identified as having acute bacterial prostatitis after the biopsy. Fifteen patients (1.2%) had acute prostatitis after the first biopsy, and 6 patients (2.03%) experienced acute prostatitis after a repeat biopsy. Even though the incidence of acute bacterial prostatitis was higher after repeat biopsy than that after the first biopsy, there was no statistically significant intergroup difference in terms of incidence (?2=1.223, p=0.269). When the collected urine and blood samples were cultured, Escherichia coli was found in samples from 15 patients (71.4%), Klebsiella pneumoniae in 3 patients (14.3%), Enterobacter intermedius in 1 patient (4.8%), E. aerogenes in 1 patient (4.8%), and Pseudomonas aeruginosa in 1 patient (4.8%). A fluoroquinolone-resistant strain was confirmed in 5 cases (23.8%) in total. Three cases of E. coli and 1 case of Klebsiella had extended-spectrum ?-lactamase activity. Conclusions Empirical treatment of acute prostatitis should be done with consideration of geographical prevalence and drug resistance. This study will provide meaningful information for the management of acute prostatitis after transrectal prostate biopsy. PMID:23550205

Bang, Jun-Ho; Choe, Hyun-Sop; Lee, Dong-Sup; Lee, Seung-Ju

2013-01-01

77

Percutaneous transthoracic CT guided biopsies of lung lesions; fine needle aspiration biopsy versus core biopsy  

PubMed Central

Background The purpose of this retrospective study was to compare the results and complication rate in CT guided percutaneous trans-thoracic fine needle aspiration biopsies (FNAB) and core biopsies of lung lesions, and to determine the applicability of these needles. Patients and methods In 242 patients (166 males; 76 females) with mean age of 58.9 years (13–84 years) CT guided biopsies of lung lesions were performed on dual slice CT equipment. The average diameter of lung lesion was 2.9 cm (1.2–6.3 cm). For FNAB’s 20 – 22 G Chiba needles and for core biopsies 14 G biopsy needles were used. The samples were sent for the histological analysis. The cytological or histological results and the eventual complications were compared. Results FNAB’s cytological samples were adequate for definitive diagnosis in 117 patients (79.60 %) and inadequate in 30 patients (20.40 %). Core biopsies samples were adequate in 92 (96.85 %) patients and non- representative (necrotic tissue) in 3 (3.15 %). Pneumothorax as the most frequent complication was detected in 14 (9.7 %) of the patients in the group of FNAB’s and in 30 (31.5 %) of the patients with the core biopsy group. Conclusions The results showed that percutaneous transthoracic CT guided biopsies of lung lesions were an effective and safe procedure in the diagnosis of lung lesions. Core biopsy gives a higher percentage of representative samples than FNAB, and is a preferred method regardless of the higher rate of complications. PMID:22933975

Beslic, Serif; Zukic, Fuad; Milisic, Selma

2012-01-01

78

Wagging tail vibration absorber  

NASA Technical Reports Server (NTRS)

A 750-foot cantilever length of extendible-tape boom (very low stiffness) was considered as the main system to be damped. A number of tail lengths were tried from 20 feet to 80 feet after which 40 feet was investigated further as a desirable compromise between performance and practical lengths. A 40-foot damping tail produced a damping effect on the main boom for the first mode equivalent in decay rate to 3.1 percent of critical damping. In this case the spring-hinge and tail were tuned to the main boom first mode frequency and the hinge damping was set at 30 percent of critical based on the tail properties. With this same setting, damping of the second mode was .4 percent and the third mode .1 percent.

Barclay, R. G.; Humphrey, P. W.

1969-01-01

79

Human tail and myelomeningocele.  

PubMed

The human tail is rarely reported and is usually associated with underlying spina bifida occulta. A male newborn presenting a caudal appendage (human tail) with skin-covered myelomeningocele and tethered cord is described. Surgical excision of the human tail and repair of the myelomeningocele were performed 3 days after birth. After the operation, the patient had an uneventful convalescence and received follow-up at our outpatient clinic without any neurological sequelae. To our knowledge, no similar case report exists in the literature. Like other skin-related lesions in the lumbosacral area, the present case of caudal appendage with myelomeningocele is only a cutaneous sign of underlying spinal dysraphism since the skin and nerve system are related by their similar ectodermal origin. After excision of the tail and repair of an underlying lesion, long-term follow-up of the neurological status is warranted. PMID:17627154

Lin, Pei-Jung; Chang, Yu-Tang; Tseng, Hsing-I; Lin, Jan-You; Huang, Yu-Sheng

2007-01-01

80

Gram stain of tissue biopsy  

MedlinePLUS

Gram stain of tissue biopsy test involves using crystal violet stain to test a sample of tissue ... a microscope slide. The specimen is stained with crystal violet stain and goes through more processing before ...

81

Heavy Tails in Insurance Sren Asmussen  

E-print Network

distribution models used in fire, wind­storm or flood insurance and mention some insurance applications in insurance data, for instance in fire, wind­storm or flood insurance (collectively known as catastropheeqf21/008 Heavy Tails in Insurance Søren Asmussen Vicky Fasen and Claudia Klüppelberg Abstract

82

Air Suctioning During Colon Biopsy Acquisition Reduces Bacterial Contamination  

Microsoft Academic Search

Abstract Background,and Aim: Contamination,of endoscopy,suites,with,bacteria,during,procedures,is of concern particularly,through,droplets,during,handling,of biopsy,specimens.,It has been,advocated,that,suctioning while,removing,the biopsy,forceps,could,help,to reduce,potentially,hazardous,bioaerosols.,The aim of the present,study,was to evaluate,the efficacy,of air suctioning,during,removal,of the biopsy,forceps. Materials,and Methods: Airborne,bacteria,were,collected,by an impactor,air-sampler,(MAS-100). Fifty liters,of air were,collected,continuously,for 30 seconds at a 30 cm distance,from,the colonoscope,suction channel.,Room air samples,were,taken,in the endoscopy,suite,in the morning,prior,to the beginning,of

Stephan R. Vavricka; Radu Tutuian; Alexander Imhof; Stephan Wildi; Christoph Gubler; Heiko Fruehauf; Christian Ruef; Michael Fried

83

Reconnaissance Soil Geochemistry at the Riverton Uranium Mill Tailings Remedial Action Site, Fremont  

E-print Network

Reconnaissance Soil Geochemistry at the Riverton Uranium Mill Tailings Remedial Action Site, Reconnaissance soil geochemistry at the Riverton Uranium Mill Tailings Remedial Action Site, Fremont County.....................................................................................................................................................link Figures Figure 1. Location of 19 soil samples collected from the Riverton Uranium Mill Tailings Remedial

Fleskes, Joe

84

Does uctuating asymmetry of antlers in white-tailed deer (Odocoileus virginianus) follow  

E-print Network

Does uctuating asymmetry of antlers in white-tailed deer (Odocoileus virginianus) follow patterns to produce. We collected morphometric and antler data from 439 white-tailed deer (Odocoileus virginianus; £uctuating asymmetry; handicap hypothesis; Odocoileus virginianus; sexual selection; white-tailed deer 1

Ditchkoff, Steve

85

Oral biopsy: oral pathologist's perspective.  

PubMed

Many oral lesions may need to be diagnosed by removing a sample of tissue from the oral cavity. Biopsy is widely used in the medical field, but the practice is not quite widespread in dental practice. As oral pathologists, we have found many artifacts in the tissue specimen because of poor biopsy technique or handling, which has led to diagnostic pitfalls and misery to both the patient and the clinician. This article aims at alerting the clinicians about the clinical faults arising preoperatively, intraoperatively and postoperatively while dealing with oral biopsy that may affect the histological assessment of the tissue and, therefore, the diagnosis. It also reviews the different techniques, precautions and special considerations necessary for specific lesions. PMID:22842360

Kumaraswamy, K L; Vidhya, M; Rao, Prasanna Kumar; Mukunda, Archana

2012-01-01

86

Stereotactic excisional breast biopsies utilizing the advanced breast biopsy instrumentation system  

Microsoft Academic Search

ObjectiveTo compare the Stereotactic excisional breast biopsy ABBI (Advanced Breast Biopsy Instrumentation) system with “open” excisional breast biopsy with needle localization. Methods: Twenty-three women underwent excisional breast biopsy using the ABBI system, 23 women concomitantly underwent needle localization and excisional breast biopsy. All women had mammograms displaying microcalcifications or nonpalpable noncystic nodular densities suspicious for cancer.

Philip C. D'Angelo; Domingo E. Galliano; Alexander S. Rosemurgy

1997-01-01

87

"Tails" of Linguistic Survival  

ERIC Educational Resources Information Center

Given the relatively short history of computerized corpora of spoken language, it is not surprising that few diachronic studies have been done on the grammatical features recently highlighted by the analysis of such corpora. This article, however, does take a diachronic perspective on one such feature: the syntactic feature of "tails" (Dik 1978).…

Timmis, Ivor

2010-01-01

88

Managing 'tail liability'.  

PubMed

To reduce and control their level of tail liability, hospitals should: Utilize a self-insurance vehicle; Consider combined limits between the hospital and physicians; Communicate any program changes to the actuary, underwriter, and auditor; Continue risk management and safety practices; Ensure credit is given to the organization's own medical malpractice program. PMID:24340649

Frese, Richard C; Weber, Ryan J

2013-11-01

89

Dr. G. Ward Wilson 1 Tailings Stability TAILINGS DAM STABILITY  

E-print Network

·construction costs occur over life of mine - lower discounted cash flow, lower cash requirements at startup of mine operator ·planning and scheduling of construction required #12;Dr. G. Ward Wilson 2 TailingsDr. G. Ward Wilson 1 Tailings Stability TAILINGS DAM STABILITY · Construction staged over the life

Boisvert, Jeff

90

Vacuum enhanced cutaneous biopsy instrument  

DOEpatents

A syringe-like disposable cutaneous biopsy instrument equipped with a tubular blade at its lower end, and designed so that a vacuum is created during use, said vacuum serving to retain undeformed a plug of tissue cut from a patient's skin.

Collins, Joseph (St. Petersburg, FL)

2000-01-01

91

Bone Biopsy: Indications and Methods  

Microsoft Academic Search

In the context of metabolic bone disorders, obtaining biopsies of iliac bone can be useful for establishing a diagnosis in an individual patient or for investigating pathomechanisms when a series of samples is examined. Although bone specimens are usually decalcified for routine pathology to facilitate sample processing, when investigating metabolic bone disorders it is usually much more informative to analyse

Frank Rauch

2009-01-01

92

Tail Density Archimedean and t Copulas Tail Densities of Vines Concluding Remarks A tail density approach in extremal  

E-print Network

Tail Density Archimedean and t Copulas Tail Densities of Vines Concluding Remarks A tail density of Mathematics Washington State University Munich, May 2011 Haijun Li A tail density approach in extremal dependence analysis for vine copulas Munich, May 2011 1 / 21 #12;Tail Density Archimedean and t Copulas Tail

Li, Haijun

93

Clinicopathological Study of Prostatic Biopsies  

PubMed Central

Introduction: Prostatism is a common malady in the geriatric age group. Benign prostatic hyperplasia and Carcinoma of the prostate are increasingly frequent with advancing age. The aim of the present study is to study the spectrum of prostatic lesions among the biopsies received in a rural hospital. Materials and Methods: One hundred and six cases of prostatic biopsies received in the Department of Pathology, Rajah Muthiah Medical College and Hospital – Annamalai University were included in the present study. There were 44 needle biopsies and 62 TURP specimens. All the specimens were fixed in 10% neutral buffered formalin and 5? sections were stained with Hematoxylin and Eosin stain (H & E stain). Relevant clinical data including age, the presenting complaints and S.PSA values in suspected cases of carcinoma prostate were recorded. Results: Among the 106 biopsies received, 79 (74.52%) cases were of Benign prostatic hyperplasia, two cases (1.89%) were Prostatic intraepithelial neoplasia and 25 cases (23.58%) were Carcinoma of Prostate. Prostatitis was the most common associated lesion in cases of benign prostatic hyperplasia presenting in 25.31% patients. Among the Carcinoma patients, 20 cases (80%) were of Adenocarcinoma of prostate and 5 cases (20%) were Small cell carcinoma of prostate. Both Benign prostatic hyperplasia and Carcinoma prostate were common in the seventh decade. Most common clinical presentation was difficulty in micturition. Most common histological type of Carcinoma prostate was Adenocarcinoma. Serum PSA estimation was done in 49 cases of prostate biopsies. Elevations of serum PSA levels were noted in both BPH and Carcinoma prostate patients.Eight cases of BPH, had serum PSA values in the range of 0-4ng/ml. Six cases of Carcinoma prostate ,had serum PSA values in the range of >80 ng/ml. Conclusion: Benign prostatic hyperplasia is the most commonly encountered prostatic lesion. Although, investigations like transrectal ultrasonogram and serum PSA estimation aids in diagnosis, a definitive diagnosis of benign and malignant lesions of prostate can be made by histopathological study of prostatic biopsies. PMID:25386437

2014-01-01

94

Testing Biopsy and Cytology Specimens for Cancer  

MedlinePLUS

... articles window. My Saved Articles » My ACS » Testing Biopsy and Cytology Specimens for Cancer Download Printable Version [ ... on the topics below to get started. Testing Biopsy and Cytology Specimens for Cancer How is cancer ...

95

Advanced breast biopsy instrumentation: a critique  

Microsoft Academic Search

Background:Large-core biopsies or open biopsies with needle localization have been the mainstay of treatment for evaluating nonpalpable mammographic abnormalities. The newly introduced Advanced Breast Biopsy Instrumentation (ABBI) system combines digital stereotactic imaging with a highly developed single-use biopsy device to locate and remove a radiographically discovered breast lesion to an accuracy of 1 mm.Study Design:We conducted a review of the

George S Ferzli; James B Hurwitz; Tracy Puza; Susan Van Vorst-Bilotti

1997-01-01

96

20 CFR 718.106 - Autopsy; biopsy.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 2010-04-01 false Autopsy; biopsy. 718.106 Section 718.106 Employees...of Medical Evidence § 718.106 Autopsy; biopsy. (a) A report of an autopsy or biopsy submitted in connection with a...

2010-04-01

97

The technique of ultrasound guided prostate biopsy  

Microsoft Academic Search

This article discusses the preparations for ultrasound guided prostate biopsy, the conditions used and the process of performing a biopsy. The first step in preparing the patient is a cleansing enema before biopsy. Every author proposes the use of a preoperative antibiotic based prophylaxis. Differences may be found in the type, dosage and the duration of this preoperative application, which

Imre Romics

2004-01-01

98

Thresher Sharks Use Tail-Slaps as a Hunting Strategy  

PubMed Central

The hunting strategies of pelagic thresher sharks (Alopias pelagicus) were investigated at Pescador Island in the Philippines. It has long been suspected that thresher sharks hunt with their scythe-like tails but the kinematics associated with the behaviour in the wild are poorly understood. From 61 observations recorded by handheld underwater video camera between June and October 2010, 25 thresher shark shunting events were analysed. Thresher sharks employed tail-slaps to debilitate sardines at all times of day. Hunting events comprised preparation, strike, wind-down recovery and prey item collection phases, which occurred sequentially. Preparation phases were significantly longer than the others, presumably to enable a shark to windup a tail-slap. Tail-slaps were initiated by an adduction of the pectoral fins, a manoeuvre that changed a thresher shark's pitch promoting its posterior region to lift rapidly, and stall its approach. Tail-slaps occurred with such force that they may have caused dissolved gas to diffuse out of the water column forming bubbles. Thresher sharks were able to consume more than one sardine at a time, suggesting that tail-slapping is an effective foraging strategy for hunting schooling prey. Pelagic thresher sharks appear to pursue sardines opportunistically by day and night, which may make them vulnerable to fisheries. Alopiids possess specialist pectoral and caudal fins that are likely to have evolved, at least in part, for tail-slapping. The evidence is now clear; thresher sharks really do hunt with their tails. PMID:23874415

Oliver, Simon P.; Turner, John R.; Gann, Klemens; Silvosa, Medel; D'Urban Jackson, Tim

2013-01-01

99

Thresher sharks use tail-slaps as a hunting strategy.  

PubMed

The hunting strategies of pelagic thresher sharks (Alopias pelagicus) were investigated at Pescador Island in the Philippines. It has long been suspected that thresher sharks hunt with their scythe-like tails but the kinematics associated with the behaviour in the wild are poorly understood. From 61 observations recorded by handheld underwater video camera between June and October 2010, 25 thresher shark shunting events were analysed. Thresher sharks employed tail-slaps to debilitate sardines at all times of day. Hunting events comprised preparation, strike, wind-down recovery and prey item collection phases, which occurred sequentially. Preparation phases were significantly longer than the others, presumably to enable a shark to windup a tail-slap. Tail-slaps were initiated by an adduction of the pectoral fins, a manoeuvre that changed a thresher shark's pitch promoting its posterior region to lift rapidly, and stall its approach. Tail-slaps occurred with such force that they may have caused dissolved gas to diffuse out of the water column forming bubbles. Thresher sharks were able to consume more than one sardine at a time, suggesting that tail-slapping is an effective foraging strategy for hunting schooling prey. Pelagic thresher sharks appear to pursue sardines opportunistically by day and night, which may make them vulnerable to fisheries. Alopiids possess specialist pectoral and caudal fins that are likely to have evolved, at least in part, for tail-slapping. The evidence is now clear; thresher sharks really do hunt with their tails. PMID:23874415

Oliver, Simon P; Turner, John R; Gann, Klemens; Silvosa, Medel; D'Urban Jackson, Tim

2013-01-01

100

Disturbance propagation times to the far tail  

NASA Astrophysics Data System (ADS)

Simultaneous data collection by IMP 8 in the near-Earth solar wind and Geotail in the distant tail make possible the correlation of solar wind disturbances with their effects in the distant tail. This paper discusses some of the possible propagation times between the two spacecrafts and compares them with observed times for a particular disturbance when Geotail was near the magnetopause. The best fit matches very closely with the solar wind velocity. Several other propagation mechanisms also match the observed delay times within the observational error. The conversion processes operating across the bow shock, through the magnetosheath, and through the tail tend to maintain the net propagation speed constant, which accounts for the empirical finding that the direct solar wind transit time between IMP 8 and Geotail works pretty well. There is little if any effect of a significant delay resulting from the flow slowing down in the subsonic dayside magnetosheath. The event cannot discriminate between a windsock response of the tail to the solar wind disturbance and a standing wave response without further quantitative modeling.

Kaymaz, Z.; Petschek, H. E.; Siscoe, G. L.; Frank, L. A.; Ackerson, K. L.; Paterson, W. R.

1995-12-01

101

Basics of kidney biopsy: A nephrologist's perspective  

PubMed Central

The introduction of the kidney biopsy is one of the major events in the history of nephrology. Primary indications of kidney biopsy are glomerular hematuria/proteinuria with or without renal dysfunction and unexplained renal failure. Kidney biopsy is usually performed in prone position but in certain situations, supine and lateral positions may be required. Biopsy needles have changed with times from Vim–Silverman needle to Tru-cut needle to spring-loaded automatic gun. The procedure has also changed from blind bedside kidney biopsy to ultrasound marking to real-time ultrasound guidance to rarely computerized tomography guidance and laparoscopic and open biopsy. In very specific situations, transjugular kidney biopsy may be required. Most of the centers do kidney biopsy on short 1-day admission, whereas some take it as an outdoor procedure. For critical interpretation of kidney biopsy, adequate sample and clinical information are mandatory. Tissue needs to be stained with multiple stains for delineation of various components of kidney tissue. Many consider that electron microscopy (EM) is a must for all kidney biopsies, but facilities for EM are limited even in big centers. Sophisticated tests such as immunohistochemistry and in-situ hybridization are useful adjuncts for definitive diagnosis in certain situations. PMID:23960337

Agarwal, S. K.; Sethi, S.; Dinda, A. K.

2013-01-01

102

Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing imageguided core-needle biopsy  

NASA Astrophysics Data System (ADS)

We describe a side-firing fiber optic sensor based on near-infrared spectroscopy for guiding core needle biopsy diagnosis of breast cancer. The sensor is composed of three side firing optical fibers (two source fibers and one detection fiber), providing two source-detector separations. The entire assembly is inserted into a core biopsy needle, allowing for sampling to occur at the biopsy site. A multi-wavelength frequency-domain near-infrared instrument is used to collect diffuse reflectance in the breast tissue through an aperture on the biopsy needle before the tissue is removed for histology. Preliminary in vivo measurements performed on 10 normal or benign breast tissues from 5 women undergoing stereo- or ultrasound-guided core needle biopsy show the ability of the system to determine tissue optical properties and constituent concentrations, which are correlated with breast tissue composition derived from histopathology.

Yu, Bing; Burnside, Elizabeth S.; Sisney, Gale A.; Harter, Josephine M.; Zhu, Changfang; Dhalla, Al-Hafeez; Ramanujam, Nirmala

2007-06-01

103

Conjunctival biopsy in the diagnosis of sarcoidosis.  

PubMed Central

We prospectively studied 47 sarcoidosis suspects and compared conjunctival and transbronchial lung biopsies in these patients. Thirty-four patients had positive findings on biopsy by either method. The transbronchial biopsy was positive in 31 patients, and the conjunctival was positive in 19. The transbronchial lung biopsy was more likely to be positive in black patients (p = 0.009) and in patients with pulmonary infiltrates on chest x ray (p = 0.0044). In comparison, the conjunctival biopsy was more likely to be positive in patients with conjunctival follicles (p = 0.036), ocular abnormalities consistent with sarcoidosis (p = 0.02), and in patients with pulmonary infiltrates on chest x ray (p = 0.029). Iritis was present in 12 patients, enlarged lacrimal glands in three, and vitritis in five. We conclude that the conjunctival biopsy is an effective means of diagnosing sarcoidosis and that every sarcoidosis patient should have an ophthalmic examination. Images PMID:2390521

Spaide, R. F.; Ward, D. L.

1990-01-01

104

Stereotactic breast biopsy: pitfalls and pearls.  

PubMed

Stereotactic breast biopsies have become indispensable and the standard of care for patients in whom screening mammography or tomosynthesis reveals breast lesions suggestive of malignancy. A variety of stereotactic biopsy systems and needle types are now available, which allow more accurate sampling of lesions as well as successful biopsy of lesions in difficult locations in patients of all body habitus. We discuss how to plan, perform, and follow up stereotactic biopsies. Most importantly, we offer suggestions on how to avoid problems and complications and detail how to achieve technical success even in the most challenging cases. Stereotactic biopsy has proven over time to be an accurate and acceptable alternative to surgical biopsy for histopathologic diagnosis of breast abnormalities. Successful performance of this minimally invasive procedure spares women from undergoing potentially deforming and expensive procedures to diagnose breast disease. PMID:24636329

Huang, Monica L; Adrada, Beatriz E; Candelaria, Rosalind; Thames, Deborah; Dawson, Debora; Yang, Wei T

2014-03-01

105

Role of liver biopsy in nonalcoholic fatty liver disease  

PubMed Central

Nonalcoholic fatty liver disease (NAFLD), defined as abnormal accumulation (> 5%) of hepatic triglyceride without excess alcohol intake, is the most common form of chronic liver disease in adults and children in the United States. NAFLD encompasses a spectrum of histologic findings including uncomplicated steatosis, steatosis with inflammation and steatohepatitis [nonalcoholic steatohepatitis (NASH)]; the latter can advance to cirrhosis and hepatocellular carcinoma. NASH is currently accepted as the hepatic manifestation of the set of cardiovascular risk factors collectively known as metabolic syndrome. In 1999 a system for histologic grading and staging for NASH was proposed; this was revised by the NASH Clinical Research Network in 2005 for the entire spectrum of lesions in NAFLD, including the lesions and patterns of pediatric NAFLD, and for application in clinical research trials. Diagnosis remains distinct from grade and stage. A recent European proposal separates steatosis from activity to derive a numeric diagnosis of NASH. Even though there have been promising advancements in non-invasive testing, these tests are not yet detailed enough to replace the full range of findings provided by liver biopsy evaluation. Limitations of biopsy are acknowledged, but liver biopsy remains the “gold standard” for diagnosis and determination of amounts of necroinflammatory activity, and location of fibrosis, as well as remodeling of the parenchyma in NASH. This review focuses on the specific histologic lesions of NAFLD and NASH, grading and staging, differential diagnoses to be considered, and the continuing role of the liver biopsy in this important liver disease. PMID:25083076

Nalbantoglu, ILKe; Brunt, Elizabeth M

2014-01-01

106

Utility of liver allograft biopsy obtained at procurement.  

PubMed

Extended-donor criteria (EDC) liver allografts potentiate the role of procurement biopsy in organ utilization. To expedite allocation, histologic evaluation is routinely performed upon frozen-section (FS) specimens by local pathologists. This descriptive study compares FS reports by local pathologists with permanent-section (PS) evaluation by dedicated hepatopathologists, identifies histologic characteristics underrepresented by FS evaluation, and evaluates the efficacy of a biopsy decision analysis based on organ visualization. Fifty-two liver transplants using EDC allografts evaluated by FS with PS were studied. Pathologic worksheets created by an organ procurement organization were applied in 34 FS. PS analysis included 7 staining procedures for 8 histologic criteria. PS from 56 additional allografts determined not to require donor biopsy were also analyzed. A high correlation was observed between FS and PS. Underestimation of steatosis by FS was associated with allograft dysfunction. Surgical assessment of cholestasis, congestion, and steatosis was accurate whereas inflammation, necrosis, and fibrosis were underestimated in allografts suffering parenchymal injury. In conclusion, the correlation between FS and PS is high, and significant discrepancies are rare. Biopsy is not a prerequisite for EDC utilization but is suggested in hepatitis C, hypernatremia, donation after cardiac death, or multiple EDC indications. Implementation of a universal FS worksheet could standardize histologic reporting and facilitate data collection, allocation, and research. PMID:18324657

Lo, Irene J; Lefkowitch, Jay H; Feirt, Nikki; Alkofer, Barbara; Kin, Cindy; Samstein, Benjamin; Guarrera, James V; Renz, John F

2008-05-01

107

Role of liver biopsy in nonalcoholic fatty liver disease.  

PubMed

Nonalcoholic fatty liver disease (NAFLD), defined as abnormal accumulation (> 5%) of hepatic triglyceride without excess alcohol intake, is the most common form of chronic liver disease in adults and children in the United States. NAFLD encompasses a spectrum of histologic findings including uncomplicated steatosis, steatosis with inflammation and steatohepatitis [nonalcoholic steatohepatitis (NASH)]; the latter can advance to cirrhosis and hepatocellular carcinoma. NASH is currently accepted as the hepatic manifestation of the set of cardiovascular risk factors collectively known as metabolic syndrome. In 1999 a system for histologic grading and staging for NASH was proposed; this was revised by the NASH Clinical Research Network in 2005 for the entire spectrum of lesions in NAFLD, including the lesions and patterns of pediatric NAFLD, and for application in clinical research trials. Diagnosis remains distinct from grade and stage. A recent European proposal separates steatosis from activity to derive a numeric diagnosis of NASH. Even though there have been promising advancements in non-invasive testing, these tests are not yet detailed enough to replace the full range of findings provided by liver biopsy evaluation. Limitations of biopsy are acknowledged, but liver biopsy remains the "gold standard" for diagnosis and determination of amounts of necroinflammatory activity, and location of fibrosis, as well as remodeling of the parenchyma in NASH. This review focuses on the specific histologic lesions of NAFLD and NASH, grading and staging, differential diagnoses to be considered, and the continuing role of the liver biopsy in this important liver disease. PMID:25083076

Nalbantoglu, I L Ke; Brunt, Elizabeth M

2014-07-21

108

Effects of tail docking on behavior of confined feedlot cattle.  

PubMed

Tail tip injuries occur in some feedlot cattle housed in slatted-floor facilities typically found in the midwestern United States. The practice of tail docking cattle on entry into these feedlot facilities was initiated to prevent tail injuries. Tail docking is a welfare concern from the standpoint that an important method of fly avoidance is removed and the tail docking procedure is painful and often excludes local anesthesia or extended analgesia. The primary objective of this study was to describe the behavioral responses of feedlot cattle following tail docking. Thirty-six heifers were randomly assigned to 1 of 2 treatment groups: docked (DK) or control (CN). All calves received an epidural following surgical preparation of the sacrococcygeal area and postoperative intravenous flunixin meglumine. A portion of the tail of DK calves was removed using pruning shears. An elastrator band was placed near the tail tip for hemostasis and tail tips were sprayed with fly spray. IceQube accelerometers collected step counts, motion index, lying time, lying bouts, and lying bout duration during d -4 through 13. Direct observations of cattle behavior were performed on d 0, 1, and 2. Step counts of DK calves were increased (P < 0.05) on d 0, 2, 3, 4, 6, 9, 10, and 13, and motion index of DK calves was also increased (P < 0.05) on d 0, 3, 4, 9, 10, 11, and 13. Docked cattle performed rear foot stomp behavior more (P < 0.001) than CN on d 0, 1, and 2. Forty-eight hours after tail docking, DK calves had increased lying bouts per hour (1.7 vs. 0.9 on d 0; P < 0.001; 1.1 vs. 0.8 on d 1; P < 0.01) but reduced lying bout durations (12.6 vs. 47.1 min on d 0; P < 0.001; 22.6 vs. 44.7 min on d 1; P < 0.001). On d 0, DK calves twitched tails more (P < 0.05) and ruminated less (P < 0.001). Despite provision of perioperative and postoperative analgesia, we identified altered behavior in DK cattle that may reflect a compromised welfare state for tail-docked feedlot cattle. We recommend that alternative strategies to reduce tail tip injury be explored. PMID:25184836

Kroll, L K; Grooms, D L; Siegford, J M; Schweihofer, J P; Daigle, C L; Metz, K; Ladoni, M

2014-10-01

109

Teratoma in Human Tail Lipoma  

Microsoft Academic Search

We report a case of a rare congenital teratoma that developed in a lipoma attached to a remnant human tail. A male newborn baby presented with a large, 3-cm mass with an open margin, which pedunculated from a tail attached to the midline skin of the coccygeal area. Magnetic resonance images demonstrated multiple sacral spinal bifida without cord tethering, and

Se-Hyuck Park; Jee Soon Huh; Ki Hong Cho; Yong Sam Shin; Se Hyck Kim; Young Hwan Ahn; Kyung Gi Cho; Soo Han Yoon

2005-01-01

110

Helicopter tail rotor noise analyses  

Microsoft Academic Search

A study was made of helicopter tail rotor noise, particularly that due to interactions with the main rotor tip vortices, and with the fuselage separation mean wake. The tail rotor blade-main rotor tip vortex interaction is modelled as an airfoil of infinite span cutting through a moving vortex. The vortex and the geometry information required by the analyses are obtained

A. R. George; S. T. Chou

1986-01-01

111

NOISE IN THE GEOMAGNETIC TAIL  

Microsoft Academic Search

Present observations have revealed a variety of magnetic wave phenomena in the tail, from ULF to ELF frequencies. However, only VLF measurements of electric fields have been made. These measurements reveal that the tail is electrically quiet at VLF fre- quencies, except in the near Earth plasma sheet during substorm expansion phases. The mag- netic waves observed iocIude: waves with

CHRISTOPHER T. RUSSELL

1972-01-01

112

Trends in Tailing Dam Safety  

Microsoft Academic Search

Recent releases of tailing effluents and solids from containment facilities around the world, including Mary Spruitt (1994), Omai (1995) and Marcopper (1996), have heightened awareness that risks associated with tailing containment must be fully addressed during all phases of a facility life. Recent studies by independent international organizations (United Nations Environment Programme (UNEP), 1996; United Stated Committee on Large Dams

Iain G. Bruce; Clint Logue; Lori-Ann Wilchek

113

Purulent pericarditis after transbronchial biopsy.  

PubMed

A 28-year-old woman experienced hypotension and unresponsiveness. She had undergone bronchoscopy with needle biopsy 2 weeks before admission to evaluate hilar lymphadenopathy given suspicion of sarcoidosis. She had an elevated white blood cell count of 28,000/?L and a serum creatinine level of 4.0 mg/dL. Echocardiography showed a large pericardial effusion. Pericardiocentesis resulted in removal of 400 mL of yellow-green purulent material that grew Streptococcus milleri, Prevotella, Veillonella, and Peptostreptococcus species. Pericardiectomy and mediastinal washout were performed. Subsequently, her condition rapidly improved. She returned home after 26 days of admission. At 12-month follow-up, the patient had made a full recovery. PMID:25138484

Tachjian, Ara; Shafer, Keri M; Denkinger, Claudia; Pinto, Duane S

2014-10-01

114

Lift generation by the avian tail.  

PubMed

Variation with tail spread of the lift generated by a bird tail was measured on mounted, frozen European starlings (Sturnus vulgaris) in a wind tunnel at a typical air speed and body and tail angle of attack in order to test predictions of existing aerodynamic theories modelling tail lift. Measured lift at all but the lowest tail spread angles was significantly lower than the predictions of slender wing, leading edge vortex and lifting line models of lift production. Instead, the tail lift coefficient based on tail area was independent of tail spread, tail aspect ratio and maximum tail span. Theoretical models do not predict bird tail lift reliably and, when applied to tail morphology, may underestimate the aerodynamic optimum tail feather length. Flow visualization experiments reveal that an isolated tail generates leading edge vortices as expected for a low-aspect ratio delta wing, but that in the intact bird body-tail interactions are critical in determining tail aerodynamics: lifting vortices shed from the body interact with the tail and degrade tail lift compared with that of an isolated tail. PMID:11454286

Maybury, W J; Rayner, J M; Couldrick, L B

2001-07-22

115

Lift generation by the avian tail.  

PubMed Central

Variation with tail spread of the lift generated by a bird tail was measured on mounted, frozen European starlings (Sturnus vulgaris) in a wind tunnel at a typical air speed and body and tail angle of attack in order to test predictions of existing aerodynamic theories modelling tail lift. Measured lift at all but the lowest tail spread angles was significantly lower than the predictions of slender wing, leading edge vortex and lifting line models of lift production. Instead, the tail lift coefficient based on tail area was independent of tail spread, tail aspect ratio and maximum tail span. Theoretical models do not predict bird tail lift reliably and, when applied to tail morphology, may underestimate the aerodynamic optimum tail feather length. Flow visualization experiments reveal that an isolated tail generates leading edge vortices as expected for a low-aspect ratio delta wing, but that in the intact bird body-tail interactions are critical in determining tail aerodynamics: lifting vortices shed from the body interact with the tail and degrade tail lift compared with that of an isolated tail. PMID:11454286

Maybury, W J; Rayner, J M; Couldrick, L B

2001-01-01

116

Multiple biopsies are superior to a single biopsy in detecting cervical cancer precursors  

Cancer.gov

Performing multiple biopsies during a procedure known as colposcopy—visual inspection of the cervix—is more effective than performing only a single biopsy of the worst-appearing area for detecting cervical cancer precursors. This multiple biopsy approach may help to detect disease early and avoid repeated biopsies for women with initial negative findings, according to a new study by Nicolas Wentzensen, M.D., Ph.D., in DCEG's Hormonal and Reproductive Epidemiology Branch, and colleagues.

117

Multiple biopsies are superior to a single biopsy in detecting cervical cancer precursors  

Cancer.gov

Performing multiple biopsies during a procedure known as colposcopy—visual inspection of the cervix—is more effective than performing only a single biopsy of the worst-appearing area for detecting cervical cancer precursors. This multiple biopsy approach may help to detect disease early and avoid repeated biopsies for women with initial negative findings, according to a new study by researchers at the National Cancer Institute and their colleagues.

118

Adequate histologic sectioning of prostate needle biopsies.  

PubMed

No standard method exists for sampling prostate needle biopsies, although most reports claim to embed 3 cores per block and obtain 3 slices from each block. This study was undertaken to determine the extent of histologic sectioning necessary for optimal examination of prostate biopsies. We prospectively compared the impact on cancer yield of submitting 1 biopsy core per cassette (biopsies from January 2010) with 3 cores per cassette (biopsies from August 2010) from a large national reference laboratory. Between 6 and 12 slices were obtained with the former 1-core method, resulting in 3 to 6 slices being placed on each of 2 slides; for the latter 3-core method, a limit of 6 slices was obtained, resulting in 3 slices being place on each of 2 slides. A total of 6708 sets of 12 to 18 core biopsies were studied, including 3509 biopsy sets from the 1-biopsy-core-per-cassette group (January 2010) and 3199 biopsy sets from the 3-biopsy-cores-percassette group (August 2010). The yield of diagnoses was classified as benign, atypical small acinar proliferation, high-grade prostatic intraepithelial neoplasia, and cancer and was similar with the 2 methods: 46.2%, 8.2%, 4.5%, and 41.1% and 46.7%, 6.3%, 4.4%, and 42.6%, respectively (P = .02). Submission of 1 core or 3 cores per cassette had no effect on the yield of atypical small acinar proliferation, prostatic intraepithelial neoplasia, or cancer in prostate needle biopsies. Consequently, we recommend submission of 3 cores per cassette to minimize labor and cost of processing. PMID:23764163

Bostwick, David G; Kahane, Hillel

2013-08-01

119

[Muscle biopsy in children: Usefulness in 2012].  

PubMed

Muscle biopsy is a mainstay diagnostic tool for investigating neuromuscular disorders in children. We report the yield of pediatric muscle biopsy in a population of 415 children by a retrospective study of 419 biopsies performed between 1/01/2000 and 31/12/2009 in a neuropediatric department, including mitochondrial respiratory chain analysis for 87 children. Two hundred and fifty-five biopsies were from boys (61%) 164 from girls (39%). Their mean age at biopsy was 6.5years; 155 (37%) biopsies were obtained before the child was 5years old. Final histopathological diagnoses were: congenital myopathy (n=193, including 15 structural congenital myopathies); progressive muscular dystrophy (n=75 [18%] including 57 dystrophinopathies); congenital muscular dystrophy (n=17, including six primary merosinopathies); dermatomyositis (n=11); spinal muscular atrophy (n=9, including six atypical spinal muscular atrophies); metabolic myopathy (n=32, including 19 mitochondrial myopathies); encephalomyopathy (n=53 [13%], including 27 with a mitochondrial respiratory chain defect). Pathological diagnosis remained undetermined in 16 cases. In 184 patients (44%), the muscle biopsy revealed specific histopathological anomalies (dystrophic process; specific ultrastructural abnormalities; perifascicular atrophy; neurogenic atrophy; metabolic anomalies) enabling a precise etiological diagnosis. For 85% of progressive muscular dystrophies, the biopsy resulted in a genetic diagnosis after identification of the protein defect. In 15% of the congenital myopathies, histopathological anomalies focused attention on one or several genes. Concerning dystrophinopathies, quantification of dystrophin deficiency on the biopsy specimen contributed to the definition of the clinical phenotype: Duchenne, or Becker. In children with a myopathy, muscle biopsy is often indispensable to establish the etiological diagnosis. Based on the results from this series, muscle biopsy can provide a precise orientation in 45% of patients, leading to a genetic hypothesis. PMID:23993361

Cuisset, J-M; Maurage, C-A; Carpentier, A; Briand, G; Thévenon, A; Rouaix, N; Vallée, L

2013-01-01

120

Postmortem evaluation of four randomly selected automated biopsy devices for transthoracic lung biopsy  

Microsoft Academic Search

Purpose: To evaluate four automated devices to achieve transthoracic lung biopsy, Methods: Transthoracic lung biopsy specimens were obtained randomly from 21 human cadavers with unsuspicious lungs using Biopty (18- and 20-gauge), BIP (18 and 20-gauge), ASAP (18 gauge), and Autovac (18- and 20-gauge) devices. A total of 63 biopsies were carried out with each device and each needle diameter. The

Hans-Joachim Wagner; Peter Barth; Carmen Schade-Brittinger; Sven Plein; Klaus-Jochen Klose

1995-01-01

121

Histopathological screening for prostate carcinoma: is a benign biopsy a negative biopsy?  

PubMed

In case of clinical suspicion of a prostate malignancy, a prostate biopsy is the most widely used approach to confirm prostate cancer. Unfortunately, exclusion of prostate cancer is not feasible by means of biopsy and also the negative rate remains consistently high. Here, we review the information the surgical pathologist can still gain from a prostate biopsy in absence of overt carcinoma. PMID:25046199

Sailer, Verena; Kristiansen, Glen

2014-08-01

122

Breast Cancer Risk Prediction and Mammography Biopsy Decisions  

PubMed Central

Background Controversy continues about screening mammography, in part because of the risk of false-negative and false-positive mammograms. Pre-test breast cancer risk factors may improve the positive and negative predictive value of screening. Purpose To create a model that estimates the potential impact of pre-test risk prediction using clinical and genomic information on the reclassification of women with abnormal mammograms (BI-RADS3 and BI-RADS4 [Breast Imaging-Reporting and Data System]) above and below the threshold for breast biopsy. Methods The current study modeled 1-year breast cancer risk in women with abnormal screening mammograms using existing data on breast cancer risk factors, 12 validated breast cancer single nucleotide polymorphisms (SNPs), and probability of cancer given the BI-RADS category. Examination was made of reclassification of women above and below biopsy thresholds of 1%, 2%, and 3% risk. The Breast Cancer Surveillance Consortium data were collected from 1996 to 2002. Data analysis was conducted in 2010 and 2011. Results Using a biopsy risk threshold of 2% and the standard risk factor model, 5% of women with a BI-RADS3 mammogram had a risk above the threshold, and 3% of women with BIRADS4A mammograms had a risk below the threshold. The addition of 12 SNPs in the model resulted in 8% of women with a BI-RADS3 mammogram above the threshold for biopsy and 7% of women with BI-RADS4A mammograms below the threshold. Conclusions The incorporation of pre-test breast cancer risk factors could change biopsy decisions for a small proportion of women with abnormal mammograms. The greatest impact comes from standard breast cancer risk factors. PMID:23253645

Armstrong, Katrina; Handorf, Elizabeth A.; Chen, Jinbo; Demeter, Mirar N. Bristol

2012-01-01

123

Ultrasound-Guided Fine Needle Biopsy of Pancreatic Masses: Results of a Multicenter Study  

Microsoft Academic Search

Objective:The aim of this study was to investigate the results of ultrasound-guided fine needle biopsy of pancreatic masses in a large multicenter series.Methods:This study collected the data of 510 patients who had a final diagnosis available and who had undergone ultrasound-guided fine needle biopsy of the pancreas. Retrieval rate, sensitivity, specificity, and overall diagnostic accuracy of the whole series, by

Michele Di Stasi; Riccardo Lencioni; Luigi Solmi; Fabrizio Magnolfi; Eugenio Caturelli; Ilario De Sio; Andrea Salmi; Luigi Buscarini

1998-01-01

124

Labial salivary gland biopsy in Sjögren's disease  

Microsoft Academic Search

A labial biopsy technique is described and was used to study 40 patients with connective tissue disease and 60 postmortem subjects. More than one focus of lymphocytes per 4 sq mm of minor salivary tissue was found to be a consistent finding in patients with Sjögren's disease. The labial biopsy is shown to be a further valuable investigative procedure in

D. M. Chisholm; D. K. Mason

1968-01-01

125

Our approach to a renal transplant biopsy  

Microsoft Academic Search

Kidney transplantation has become increasingly common in major health centres, making renal allograft evaluation through biopsy a common procedure. Early allograft dysfunction occurs in 30–50% of all transplants, while chronic graft failure is almost uniform at a rate of 2–4% a year. Allograft biopsy remains the gold standard for the diagnosis of graft dysfunction. Rejection, albeit the most important, is

R John; A M Herzenberg

2010-01-01

126

Transjugular Liver Biopsy: Results of 97 Patients  

PubMed Central

Objective: To evaluate the feasibility and efficacy of transjugular liver biopsy in patients with contraindicated percutaneous biopsy. Materials and Methods: Between June 2005 and April 2010, 97 patients who were admitted for transjugular liver biopsy were enrolled in this retrospective study. All liver biopsies were obtained using an 18 gauge Quick-Core liver biopsy set through the right hepatic vein via the internal jugular vein. Clinical indication, histopathological diagnosis, and complications were noted. Results: Primary technical success was achieved in 93 (95.8%) patients. Hepatic veins could not be catheterized and opacified in two patients and in the remaining two patients the veins could be opacified and catheterized but we were not able to pass the biopsy needle into the hepatic vein because of the acute angle between the inferior vena cava and hepatic veins. At least two specimens were obtained from each patient. The most frequent histopathological diagnosis was cirrhosis. A subcutaneous hematoma around the puncture side was encountered in one patient. Conclusion: Transjugular liver biopsy is a feasible and effective alternative in patients with contraindication for percutaneous biopsy.

Donmez, Halil; Kahriman, Guven; Ozcan, Nevzat; Mavili, Ertugrul; Deniz, Kemal

2012-01-01

127

[Surgical lung biopsy: Indications and therapeutic implications].  

PubMed

Surgical biopsy of lung parenchyma can be used to establish a diagnosis in interstitial lung disease both of acute and chronic presentation. The present article summarizes the current indications, the therapeutic implications, the different surgical techniques and postoperative complications of the procedure. Common controversies and problems related to surgical lung biopsy are also presented. PMID:22425502

Radu, D M; Macey, J; Bouvry, D; Seguin, A; Valeyre, D; Martinod, E

2012-04-01

128

Reye's syndrome; diagnosis by muscle biopsy?  

Microsoft Academic Search

Three children with Reye's syndrome are described. One child died, the second had mild and transient illness, and the third had recurrent episodes. In all 3 children a muscle biopsy showed pronounced infiltration of the myofibres with fat microdroplets as shown by the oil red O stain and by electron microscopical examination. We suggest that needle biopsy of muscle may

Y Shapira; R Deckelbaum; M Statter; A Tennenbaum; M Aker; R Yarom

1981-01-01

129

Mercury's Dynamic Magnetic Tail  

NASA Technical Reports Server (NTRS)

The Mariner 10 and MESSENGER flybys of Mercury have revealed a magnetosphere that is likely the most responsive to upstream interplanetary conditions of any in the solar system. The source of the great dynamic variability observed during these brief passages is due to Mercury's proximity to the Sun and the inverse proportionality between reconnection rate and solar wind Alfven Mach number. However, this planet's lack of an ionosphere and its small physical dimensions also contribute to Mercury's very brief Dungey cycle, approx. 2 min, which governs the time scale for internal plasma circulation. Current observations and understanding of the structure and dynamics of Mercury's magnetotail are summarized and discussed. Special emphasis will be placed upon such questions as: 1) How much access does the solar wind have to this small magnetosphere as a function of upstream conditions? 2) What roles do heavy planetary ions play? 3) Do Earth-like substorms take place at Mercury? 4) How does Mercury's tail respond to extreme solar wind events such coronal mass ejections? Prospects for progress due to advances in the global magnetohydrodynamic and hybrid simulation modeling and the measurements to be taken by MESSENGER after it enters Mercury orbit on March 18, 2011 will be discussed.

Slavin, James A.

2010-01-01

130

Peroral small-intestinal biopsy: experience with the hydraulic multiple biopsy instrument in routine clinical practice.  

PubMed Central

Experience of the peroral, hydraulic, multiple, small-bowel biopsy instrument is recorded and compared with reported experience of other peroral biopsy instruments. It is concluded that, in routine clinical practice, there is no particular danger associated with this instrument despite warnings to the contrary. Furthermore, biopsies are obtained at least as quickly as with other instruments and with great reliability. Since this instrument also enables multiple, precisely located biopsies to be taken from various levels of the small intestine, it could be considered the instrument of choice for peroral jejunal biopsy. PMID:1086269

Scott, B B; Losowsky, M S

1976-01-01

131

Arsenic bioaccessibility in gold mine tailings of Delita, Cuba.  

PubMed

A bioaccessibility test was carried out in four tailings collected at a former mining area in Delita, Cuba. A previous risk assessment study identified arsenic (As) as the main critical contaminant in this area and showed that the tailings had high As concentrations (up to 3.5%). This study aimed at: (i) evaluating As bioaccessibility in four tailings (R1, R2, R3 and R4) from a gold mining area to obtain a better health risk estimate; and, (ii) identifying the mineral phases responsible for most of the bioaccessible As using XRD, SEM-EDS, and XAS. The results showed that bioaccessible As in the tailings ranged from 0.65 to 40.5%. The main factors influencing As bioaccessibility were a high occurrence of amorphous iron arsenate; occurrence, even at low content, of iron oxyhydroxides and stability of mineral phases in the environment of the gastrointestinal tract. Although arsenopyrite, arsenates and goethite were confirmed by mineralogical methods such as optical microscopy, XRD, and SEM-EDS, XAS showed that scorodite-oxidation state As(+V)-was dominant in most of the tailings. This confirms that the low bioaccessibility of As in most of the tailings is due to the slow kinetics of As release from scorodite. PMID:23428178

Toujaguez, R; Ono, F B; Martins, V; Cabrera, P P; Blanco, A V; Bundschuh, J; Guilherme, L R G

2013-11-15

132

Molycorp Guadalupe Mountain tailings disposal facility. Final report  

SciTech Connect

Molycorp proposes to construct and operate a molybdenum tailings disposal facility on 1,230 acres of public land near Questa, New Mexico and has located mill site claims for this purpose. The project would consist of a 568-acre tailings pond in the saddle of Guadalupe Mountain. The pond would be formed by the construction of two rock-filled dams at either end of the saddle. Other facilities would include a tailings pump station, an extension of the tailings pipeline, tailings distribution lines, access roads and a patrol road, a powerline, a seepage collection pond, surface water diversion channels, and a decant water channel. The project would provide additional storage for approximately 200 million tons of tailings from Molycorp's molybdenum mine located approximately 12 miles east of Guadalupe Mountain. The Bureau of Land Management (BLM) completed an Environmental Assessment (EA) for this project in February 1985. As a result of that EA, the BLM determined that an Environmental Impact Statement (EIS) would be required. The EIS analyzes and documents the environmental impacts of the proposed project through construction, operation, and closure.

Not Available

1989-11-01

133

GASTROINTESTINAL MORPHOLOGY OF FEMALE WHITE-TAILED AND MULE DEER: EFFECTS OF FIRE,  

E-print Network

, Odocoileus hemionus, Odocoileus virginianus, papillae, South Dakota, white-tailed deer Limited information; and intestinal tissue weight of reproductive and nonreproductive female white- tailed (Odocoileus virginianus) and mule deer (O. hemionus) using similar burned and unburned habitat. Deer were collected from study areas

134

On the magnetic field fluctuations during magnetospheric tail current disruption: A statistical approach  

Microsoft Academic Search

The objective of this study is to investigate the nature of the magnetic field relaxation process associated with tail current disruption on the basis of magnetic field measurements collected in the near-Earth tail regions. In detail, using magnetic field data for three current disruption (CD) events as observed by AMPTEE\\/CCE spacecraft, we investigate the scaling features of the probability distribution

Giuseppe Consolini; Matthieu Kretzschmar; Anthony T. Y. Lui; Gaetano Zimbardo; Wieslaw M. Macek

2005-01-01

135

Microbiology and Geochemistry of Mine Tailings Amended with Organic Carbon for Passive Treatment of Pore Water  

Microsoft Academic Search

A field-scale experiment was conducted to evaluate organic carbon amendment of mine tailings as a technique for pore water and drainage treatment. Six test cells were constructed by amending sulfide- and carbonate- rich tailings with varied mixtures of peat, spent-brewing grain and municipal biosolids. Samples were collected for microbial, geochemical and mineralogical analysis approximately three years after commencing this experiment.

Matthew B. J. Lindsay; Kathryn D. Wakeman; Owen F. Rowe; Barry M. Grail; Carol J. Ptacek; David W. Blowes; D. Barrie Johnson

2011-01-01

136

Distribution of the Long-tailed Weasel (Mustela frenata) in Illinois  

Microsoft Academic Search

Knowing the geographic distribution of any species is an important first step toward understanding its ecology. Long-tailed weasels (Mustela frenata) are secretive and diffi- cult to detect, so little is known about their distribution in Illinois. To fill this gap in the knowledge, we solicited information from museum curators about the sites where long-tailed weasel specimens were collected in Illinois

Saleen M. Richter; Eric M. Schauber

2006-01-01

137

Investigation of heavy metals pollution in the Huashan's gold mine tailing area  

Microsoft Academic Search

In order to identify the content of various heavy metals, soils of the farmland surrounding the Huashan's gold tailing mine are studied. Surrounding soil samples are collected in new and old tailing mines. Flame atomic absorption spectrometry is taken to measure the content of Pb, Zn, Cd, Cr, and Cu. In addition, the method of combining the Geo-accumulation index and

Xue Xicheng; Zhang Rui; Wang Pan; Bi Jisong

2011-01-01

138

18 Sharp-tailed Grouse  

Microsoft Academic Search

Tympanuchus phasianellus (Linnaeus) 1858 Other vernacular names: Brush grouse, pintail grouse, prairie grouse, prairie pheasant, sharptail, speckle-belly, spike-tail, spring-tail, whitebelly, white-breasted grouse. Range: Currently from north central Alaska, Yukon, northern Mackenzie, northern Manitoba, northern Ontario, and central Quebec south to eastern Washington, extreme eastern Oregon, Idaho, northeastern Utah, Wyoming, and Colorado, and in the Great Plains from eastern Colorado and

Paul A. Johnsgard

2008-01-01

139

Morphogenesis of the T4 tail and tail fibers  

PubMed Central

Remarkable progress has been made during the past ten years in elucidating the structure of the bacteriophage T4 tail by a combination of three-dimensional image reconstruction from electron micrographs and X-ray crystallography of the components. Partial and complete structures of nine out of twenty tail structural proteins have been determined by X-ray crystallography and have been fitted into the 3D-reconstituted structure of the "extended" tail. The 3D structure of the "contracted" tail was also determined and interpreted in terms of component proteins. Given the pseudo-atomic tail structures both before and after contraction, it is now possible to understand the gross conformational change of the baseplate in terms of the change in the relative positions of the subunit proteins. These studies have explained how the conformational change of the baseplate and contraction of the tail are related to the tail's host cell recognition and membrane penetration function. On the other hand, the baseplate assembly process has been recently reexamined in detail in a precise system involving recombinant proteins (unlike the earlier studies with phage mutants). These experiments showed that the sequential association of the subunits of the baseplate wedge is based on the induced-fit upon association of each subunit. It was also found that, upon association of gp53 (gene product 53), the penultimate subunit of the wedge, six of the wedge intermediates spontaneously associate to form a baseplate-like structure in the absence of the central hub. Structure determination of the rest of the subunits and intermediate complexes and the assembly of the hub still require further study. PMID:21129200

2010-01-01

140

TAIL VEIN INJECTION (SOP-7) INTRODUCTION  

E-print Network

TAIL VEIN INJECTION (SOP-7) INTRODUCTION Several techniques can be employed which allow within the vein. If the injection is placed subcutaneously, the tail may also blanch but the resistance, the tail can be warmed under a heat lamp. Warming the tail causes the veins to dilate. 3. Locate the right

Kleinfeld, David

141

21 CFR 870.4075 - Endomyocardial biopsy device.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 false Endomyocardial biopsy device. 870.4075 Section 870.4075...Devices § 870.4075 Endomyocardial biopsy device. (a) Identification. An endomyocardial biopsy device is a device used in a...

2010-04-01

142

The ossification process of the developing antler in the white-tailed deer ( Odocoileus virginianus )  

Microsoft Academic Search

Biopsy samples were obtained from the growing tips of the main beam and tines of two-and three-year-old, white-tailed deer (Odocoileus virginianus) throughout the active growing season. The samples were prepared by routine and special histological techniques. The histological differentiation of the antler proceeded through a complex series of changes. The series originated with reserve mesenchymal tissue, progressed through the differentiation

W. J. Banks

1974-01-01

143

Does climate have heavy tails?  

NASA Astrophysics Data System (ADS)

When we speak about a distribution with heavy tails, we are referring to the probability of the existence of extreme values will be relatively large. Several heavy-tail models are constructed from Poisson processes, which are the most tractable models. Among such processes, one of the most important are the Lévy processes, which are those process with independent, stationary increments and stochastic continuity. If the random component of a climate process that generates the data exhibits a heavy-tail distribution, and if that fact is ignored by assuming a finite-variance distribution, then there would be serious consequences (in the form, e.g., of bias) for the analysis of extreme values. Yet, it appears that it is an open question to what extent and degree climate data exhibit heavy-tail phenomena. We present a study about the statistical inference in the presence of heavy-tail distribution. In particular, we explore (1) the estimation of tail index of the marginal distribution using several estimation techniques (e.g., Hill estimator, Pickands estimator) and (2) the power of hypothesis tests. The performance of the different methods are compared using artificial time-series by means of Monte Carlo experiments. We systematically apply the heavy tail inference to observed climate data, in particular we focus on time series data. We study several proxy and directly observed climate variables from the instrumental period, the Holocene and the Pleistocene. This work receives financial support from the European Commission (Marie Curie Initial Training Network LINC, No. 289447, within the 7th Framework Programme).

Bermejo, Miguel; Mudelsee, Manfred

2013-04-01

144

[New technique of liver biopsy (author's transl)].  

PubMed

A new one way set of instruments for liver biopsy (Histocan) dissects a neat cylinder of liver parenchyma harbouring it in a special reservoir. Manipulation of Histocan is very well controllable, independent of timing, and easy to perform, making it an ideal biopsy instrument for laparoscopy. since it is a one way set, sharpening and gliding qualities are invariably good, and better prophylaxis of infection is possible. PMID:6456394

Ordnung, W; Fischer, R

1980-12-01

145

The Effectiveness of Mapping Biopsy in Patients with Extramammary Paget's Disease  

PubMed Central

Background Extramammary Paget's disease (EMPD) is an intraepithelial carcinoma usually occurring on the skin or mucosa of the perineum. Clinically, it resembles eczema or dermatitis, and misdiagnosis and treatment delays are common. The treatment of choice for EMPD is a wide excision with adequate margins. Wide excision with intraoperative frozen biopsy and Mohs micrographic surgery are common methods; however, these are associated with a high recurrence rate and long operation time, respectively. Methods Between January 2010 and June 2013, 21 patients diagnosed with EMPD underwent mapping biopsy. Biopsy specimens were collected from at least 10 areas, 2 cm from the tumor margin. When the specimens were positive for malignancy, additional mapping biopsy was performed around the biopsy site of the positive result, and continued until no cancer cells were found. Based on the results, excision margins and reconstruction plans were established preoperatively. Results The patients (18 male, 3 female) had a mean age of 66.5 years (range, 50-82 years). Almost all cases involved in the perineal area, except one case of axillary involvement. Permanent biopsy revealed one case (4.8%) of positive cancer cells on the resection margin, in which additional mapping biopsy and re-operation was performed. At the latest follow-up (mean, 27.4 months; range, 12-53 months), recurrence had not occurred. Conclusions Preoperative mapping biopsy enables accurate resection margins and a preoperative reconstructing plan. Additionally, it reduces the operation time and risk of recurrence. Accordingly, it represents an effective alternative to Mohs micrographic surgery and wide excision with intraoperative frozen biopsy.

Kim, Byung Jun; Park, Shin Ki

2014-01-01

146

New Device Technologies for Subcutaneous Fat Biopsy  

PubMed Central

Purpose Subcutaneous fat biopsy is useful for the evaluation of amyloidosis, environmental contaminants, lipid metabolism, genetic studies, and diabetes research. The present study examined new technologies for fat biopsy. Methods Subcutaneous fat biopsy in 10 high-risk individuals was randomized to 1) a 10 ml RPD (reciprocating procedure device - RPD), mechanical syringe or 2) a 60 ml vacuum syringe. Outcome measures included pain by the 10 cm Visual Analogue Pain Scale (VAS), adequacy of biopsied tissue, complications, and diagnosis. The operator’s ability to control syringes was quantitatively measured by the linear displacement method. Results Both syringes permitted facile aspiration of subcutaneous fat with adequate sample without complications. The mechanical and the vacuum syringes enhanced control of the needle compared to conventional syringes, reducing unintended forward penetration by 75% (3.6±0.5 mm) and 87% (12.0±1.4 mm), respectively (p<0.0001). Free adipose cells were obtained in abundance as well as columnar biopsies containing intact blood vessels and connective tissue septa permitting precise microhistological examination. One case of primary AL amyloidosis (kappa light chain disease) was diagnosed in each group. Conclusions Subcutaneous fat biopsy by needle aspiration can be facilely achieved with new aspiration syringe technologies with improved needle control and enhanced patient safety. PMID:22452536

Kettwich, Lawrence G.; Sibbitt, Wilmer L.; Emil, N. Suzanne; Ashraf, Usman; Sanchez-Goettler, Leslie; Thariani, Yumna; Bankhurst, Arthur D.

2013-01-01

147

Transient bacteremia associated with percutaneous liver biopsy.  

PubMed

Transient bacteremia associated with percutaneous liver biopsy was studied by pour-plate blood cultures, which were obtained immediately before and after the procedure and 5, 10, 15, and 30 min later in 89 patients. Part of the liver tissue was also cultured in all patients. Histological diagnoses included hepatitis, cirrhosis, cholangitis, fatty liver, granulomata, metastatic liver disease, lymphoma, and miscellaneous disorders. All blood cultures obtained before liver biopsy were sterile. Bacteremia was demonstrable in 12 patients (13.48%). In most of these patients, blood cultures were positive for as long as 15 min after liver biopsy; all cultures were negative at 30 min. Among the bacteria associated with 12 episodes of bacteremia were Escherichia coli, Klebsiella, Bacteroides, enterococci, diphtheroids, Staphylococcus aureus, alpha-hemolytic Streptococcus, and Streptococcus pneumoniae. The patients with positive liver biopsies had a higher incidence of bacteremia (83.3%) than did the patients whose liver biopsies were sterile (8.r%); this difference is stastically significant (P smaller than 0.01). Thus, liver biopsy can be associated with transient bactermia. PMID:1092772

Le Frock, J L; Ellis, C A; Turchik, J B; Zawacki, J K; Weinstein, L

1975-05-01

148

Testicular biopsy: clinical practice and interpretation  

PubMed Central

Testicular biopsy was considered the cornerstone of male infertility diagnosis for many years in men with unexplained infertility and azoospermia. Recent guidelines for male infertility have limited the indications for a diagnostic testicular biopsy to the confirmation of obstructive azoospermia in men with normal size testes and normal reproductive hormones. Nowadays, testicular biopsies are mainly performed for sperm harvesting in men with non-obstructive azoospermia, to be used for intracytoplasmic sperm injection. Testicular biopsy is also performed in men with risk factors for testicular malignancy. In a subgroup of infertile men, there is an increased risk for carcinoma in situ of the testis, especially in men with a history of cryptorchidism and testicular malignancy and in men with testicular atrophy. Ultrasonographic abnormalities, such as testicular microlithiasis, inhomogeneous parenchyma and lesions of the testes, further increase the risk of carcinoma in situ (CIS) in these men. For an accurate histological classification, proper tissue handling, fixation, preparation of the specimen and evaluation are needed. A standardized approach to testicular biopsy is recommended. In addition, approaches to the detection of CIS of the testis testicular immunohistochemistry are mandatory. In this mini-review, we describe the current indications for testicular biopsies in the diagnosis and management of male infertility. PMID:22157985

Dohle, Gert R; Elzanaty, Saad; van Casteren, Niels J

2012-01-01

149

Initial experience with breast biopsy utilizing the advanced breast biopsy instrumentation (ABBI)  

Microsoft Academic Search

.   The Advanced Breast Biopsy Instrumentation (ABBI) system combines a cylindrical single-use biopsy device with digital stereotactic\\u000a imaging that achieves targeting of radiographic lesions to ? 1 mm. This allows complete removal of specimens in a one-step\\u000a procedure that does not involve separate trips to radiology and then surgery. The ABBI system improves on core needle biopsy\\u000a and fine-needle aspiration

G. S. Ferzli; J. B. Hurwitz

1997-01-01

150

The technique of ultrasound guided prostate biopsy.  

PubMed

This article discusses the preparations for ultrasound guided prostate biopsy, the conditions used and the process of performing a biopsy. The first step in preparing the patient is a cleansing enema before biopsy. Every author proposes the use of a preoperative antibiotic based prophylaxis. Differences may be found in the type, dosage and the duration of this preoperative application, which can last from 2 h to 2 days. For anaesthesia, lidocaine has been proposed, which may be used as a gel applied in the rectum or in the form of a prostate infiltrate. Quite a few colleagues administer a brief intravenous narcosis. A major debate goes on in respect of defining the number of biopsy samples needed. Hodge proposed sextant biopsy in 1989, for which we had false negative findings in 20% of all cases. Because of this, it has recently been suggested that eight or rather ten samples be taken. There are some who question even this. Twelve biopsy samples do offer an advantage compared to six, although in the case of eight this is not the case. We shall present an in depth discussion of the various opinions on the different numbers of biopsies samples required. For the sample site, the apex, the base and the middle part are proposed, and (completing the process) two additional samples can also be taken from the transition zone (TZ), since 20% of all prostate cancers originate from TZ. In case of a palpable nodule or any lesion made visible by TRUS, an additional, targeted, biopsy has to be performed. Certain new techniques like the 3-D Doppler, contrast, intermittent and others shall also be presented. The control of the full length of samples taken by a gun, as well as the proper conservation of the samples, are parts of pathological processing and of the technical tasks. A repeated biopsy is necessary in the case of PIN atypia, beyond which the author also discusses other indications for a repeated biopsy. We may expect the occurrence of direct postoperative complications and it is necessary to know how to treat these. PMID:15455255

Romics, Imre

2004-11-01

151

Harmonics optical biopsy of human skin  

NASA Astrophysics Data System (ADS)

Traditional biopsy requires the removal, fixation, and staining of tissues from the human body. Its procedure is invasive and painful. Therefore, a novel method of optical biopsy is desired which can perform in vivo examination and is noninvasive, highly penetrative, with no energy deposition and damage, without invasive pharmaceutical injection, and with three-dimensional (3D) imaging capability and sub-micron spatial resolution. Two-photon fluorescence microscopy (TPFM) is previously applied for biopsy of skin due to its high lateral resolution, low out-of-focus damage, and intrinsic 3D section capability. However, for future clinical applications without surgery, current 700-850 nm based laser scanning technology still presents several limitations including low penetration depth, in-focus cell damages, multi-photon phototoxicity due to high optical intensity in the 800 nm wavelength region, and toxicity if exogenous fluorescence markers were required. Here we demonstrate a novel noninvasive optical biopsy method called harmonics optical biopsy (HOB), which combines both second harmonic generation imaging and third harmonic generation imaging. Due to virtual transition nature of harmonic generations and based on light sources with an optical wavelength located around the biological penetration window (~1300nm), our HOB can serve as a truly non-invasive biopsy tool with sub-micron three-dimensional spatial resolution without any energy deposition and exogenous contrast agents. From preliminary experiment result, our HOB can reconstruct 3D cellular and subcellular images from skin surface through dermis. Besides, by utilizing backward propagating detection geometry, we will show that this technique is ideal for non-invasive clinical biopsy of human skin diseases and even useful for the early diagnosis of skin cancer symptom such as the angiogenesis.

Tai, Shih-Peng; Tsai, Tsung-Han; Chu, Shi-Wei; Lee, Wen-Jeng; Liao, Yi-Hua; Huang, Hsin-Yi; Sun, Chi-Kuang

2005-04-01

152

Liver biopsy findings in chronic hepatitis B.  

PubMed

Liver biopsy plays a central role in treatment algorithms in patients with hepatitis B and remains the gold standard for evaluating hepatic pathology. The pathology of hepatitis B is diverse and reflects the natural history of infection. An acute hepatitic pattern with lobular disarray is seen in acute infection, during acute flares of disease, and with acute hepatitis D superinfection. In chronic hepatitis B, inflammation is less pronounced in the immune-tolerant phase and is prominent during immune-mediated viral clearance. Active inflammation appears to be the driving force for development of fibrosis. Inflammatory grades and fibrosis stage are assigned as is done for hepatitis C. Although current management guidelines recommend liver biopsies only in select patients based on age, viral levels, and hepatitis B e antigen status, these clinical and biochemical parameters do not show consistent correlations with liver histology. Liver biopsy also helps identify preneoplastic lesions including large cell and small cell change. Unlike in other causes of chronic hepatitis, immunostains are widely used and can help determine the phase of infection. Liver biopsies can also identify additional pathology that may contribute to liver disease such as steatohepatitis, iron overload, autoimmune hepatitis, and drug-induced injury. Thus, liver biopsy can play an important role in staging and grading chronic hepatitis B and should be more widely used in assessing the need for therapy. PMID:19399798

Mani, Haresh; Kleiner, David E

2009-05-01

153

Risks of Transthoracic Needle Biopsy: How High?  

PubMed

Transthoracic needle lung biopsy is a commonly performed diagnostic procedure for pulmonary nodules and masses. To make an informed decision about whether to pursue this procedure, doctors and patients must be aware of the possible risks of the procedure. We performed a MEDLINE search, 2003-2012 to identify relevant English-language studies that included at least 100 subjects and reported data on complications of transthoracic needle lung biopsy performed within the last 10 years. We found the most common complication to be any pneumothorax (risk 15-25%), with pneumothorax requiring chest tube occurring less often (risk 4-6%). Hemorrhage, defined as radiographically visualized blood along the needle tract was common, but clinically significant hemorrhage was infrequent (~1%). Rare complications, including air embolism and tumor seeding of the biopsy tract, occurred in fewer than 1% of cases but were potentially serious. We summarize data on factors associated with complications, including patient age, COPD, lesion size and location, and number of punctures. We also provide data on techniques to mitigate severity of pneumothorax post-biopsy, such as rapid patient rollover, manual aspiration, and instillation of substances into the biopsy tract. PMID:23525679

Wiener, Renda Soylemez; Wiener, Daniel C; Gould, Michael K

2013-01-01

154

Risks of Transthoracic Needle Biopsy: How High?  

PubMed Central

Transthoracic needle lung biopsy is a commonly performed diagnostic procedure for pulmonary nodules and masses. To make an informed decision about whether to pursue this procedure, doctors and patients must be aware of the possible risks of the procedure. We performed a MEDLINE search, 2003–2012 to identify relevant English-language studies that included at least 100 subjects and reported data on complications of transthoracic needle lung biopsy performed within the last 10 years. We found the most common complication to be any pneumothorax (risk 15–25%), with pneumothorax requiring chest tube occurring less often (risk 4-6%). Hemorrhage, defined as radiographically visualized blood along the needle tract was common, but clinically significant hemorrhage was infrequent (~1%). Rare complications, including air embolism and tumor seeding of the biopsy tract, occurred in fewer than 1% of cases but were potentially serious. We summarize data on factors associated with complications, including patient age, COPD, lesion size and location, and number of punctures. We also provide data on techniques to mitigate severity of pneumothorax post-biopsy, such as rapid patient rollover, manual aspiration, and instillation of substances into the biopsy tract. PMID:23525679

Wiener, Renda Soylemez; Wiener, Daniel C.; Gould, Michael K.

2013-01-01

155

Percutaneous Biopsy of Osteoid Osteomas Prior to Percutaneous Treatment Using Two Different Biopsy Needles  

SciTech Connect

Biopsy is usually performed as the first step in percutaneous treatment of osteoid osteomas prior to laser photocoagulation. At our institution, 117 patients with a presumed diagnosis of osteoid osteoma had a trephine biopsy before a percutaneous laser photocoagulation. Biopsies were made using two different types of needles. A Bonopty biopsy needle (14-gauge cannula, 16-gauge trephine needle; Radi Medical Systems, Uppsala, Sweden) was used in 65 patients, and a Laurane biopsy needle (11-gauge cannula, 12.5-gauge trephine needle; Laurane Medical, Saint-Arnoult, France) in 43 patients. Overall biopsy results were positive for osteoid osteoma in 83 (70.9%) of the 117 cases. The Laurane needle provided a significantly higher positive rate (81.4%) than the Bonopty needle (66.1%; p < 0.05). This difference was not due to the size of the nidus, which was similar in the two groups (p < 0.05) and may be an effect of differences in needle caliber (12.5 vs. 14 gauge) as well as differences in needle design. The rate of positive biopsy results obtained in the present series with the Laurane biopsy needle is, to our knowledge, the highest rate reported in series dealing with percutaneous radiofrequency ablation and laser photocoagulation of osteoid osteomas.

Laredo, Jean-Denis, E-mail: jean-denis.laredo@lrb.aphp.fr; Hamze, Bassam; Jeribi, Riadh [Hopital Lariboisiere, Service de Radiologie (France)

2009-09-15

156

No need for biopsies: comparison of three sample techniques for wound microbiota determination.  

PubMed

The aim of the study was to compare three sampling techniques used in routine diagnostics to identify the microbiota in chronic venous leg ulcers. A total of 46 patients with persisting venous leg ulcers were included in the study. At inclusion, swab, biopsy and filter paper pad samples were collected. After 4 weeks, additional biopsy and filter paper pad samples were collected. Bacteria were isolated and identified at species level by standard methods. The most common bacterial species detected was Staphylococcus aureus found in 89% of the ulcers. No methicillin-resistant S. aureus isolates were found. We did not find any significant differences regarding the bacterial species isolated between the three sampling techniques. However, using multiple techniques led to identification of more species. Our study suggests that it is sufficient to use swab specimens to identify the bacterial species present in chronic wounds, thus avoiding complications during and after biopsy sampling. PMID:22067000

Gjødsbøl, Kristine; Skindersoe, Mette E; Christensen, Jens Jørgen; Karlsmark, Tonny; Jørgensen, Bo; Jensen, Anders Mørup; Klein, Bjarke M; Sonnested, Michael K; Krogfelt, Karen A

2012-06-01

157

Black-Tailed Prairie Dog  

USGS Multimedia Gallery

Black-tailed prairie dogs are quite susceptible to sylvatic plague, but a new plague vaccine put in their food shows significant promise in the laboratory. The prairie dogs transmit the disease to endangered black-footed ferrets, who eat the prairie dogs and are also quite susceptible to the disease...

2009-08-03

158

Reliability of receptor assessment on core needle biopsy in breast cancer patients.  

PubMed

We compared the breast core needle biopsy and the resection specimen with respect to estrogen (ER), progesterone (PR) and human epidermal growth factor receptor 2 (HER2) status to identify predictors for discordant findings. We retrospectively collected data from 526 newly diagnosed breast cancer patients. ER, PR and HER2 status had been assessed in both the core needle biopsy and resection specimen. The assessment of ER by immunohistochemistry (IHC) in core needle biopsy was false negative in 26.5% and false positive in 6.8% of patients. For the PR status the false negative and false positive results of core needle biopsy were 29.6% and 10.3%, respectively. The results of the HER2 status, as determined by IHC and silver in situ hybridization (SISH), were false negative in 5.4% and false positive in 50.0%. We need to be aware of the problem of false negative and false positive test results in ER, PR and HER2 assessment in core needle biopsy and the potential impact on adjuvant systemic treatment. With current techniques, we recommend using the resection specimen to measure these receptors in patients without neoadjuvant treatment. A better alternative might be the use of tissue microarray, combining both core needle biopsy and resection specimen. PMID:23269610

Seferina, S C; Nap, M; van den Berkmortel, F; Wals, J; Voogd, A C; Tjan-Heijnen, V C G

2013-04-01

159

Tail use in bioinspired quadrupedal locomotion  

E-print Network

Tails are seen in nature to be used in an amazing number of different applications. Many of these applications seen in nature may be of use to bioinspired roboticists in the future. I have provided a brief review of tail ...

Briggs, Randall (Randall Miller)

2012-01-01

160

From metallurgical coal tailings to thermal fuel  

Microsoft Academic Search

McIntyre Mines in Canada recover coal from washery tailings slurry. The tailings are dewatered in Bird screen bowl centrifuges and thermally dried in Joy Holo-Flite dryers. The coal recovered is burned in a power station.

van den Broek

1982-01-01

161

The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn's disease and ulcerative colitis patients.  

PubMed

The bacterial community (microbiota) that inhabits the gut of humans appears to be an important source of antigens that drive the chronic immunological processes characteristic of Crohn's disease (CD) and ulcerative colitis (UC). Most of the members of the microbiota have not yet been cultured, but nucleic-acid-based methods of detection and enumeration can provide information about the community. This investigation used these methods to obtain information about the bacteria associated with mucosal surfaces in the gut of 20 CD and 15 UC patients. Biopsies were collected from inflamed and non-inflamed sites in the intestines of newly diagnosed, untreated patients. Biopsies were also collected from several intestinal sites of 14 healthy subjects. The bacterial collections associated with the biopsies were analysed by generating PCR/denaturing gradient gel electrophoresis (DGGE) profiles, the preparation of 16S rRNA gene clone libraries, and qualitative PCR to detect specific groups of bacteria. The total numbers of bacteria associated with the biopsies were determined by real-time quantitative PCR. DGGE profiles generated from the terminal ileum and various colonic regions were characteristic of each individual but differed between subjects. DGGE profiles and 16S rRNA gene libraries showed that the bacteria associated with inflamed and non-inflamed tissues did not differ. UC patients had more bacteria associated with biopsies than did CD patients (P<0.01). Statistical analysis of the composition of 16S rRNA gene libraries showed that the bacterial collections in UC and CD patients differed (P<0.05). Unclassified members of the phylum Bacteroidetes were more prevalent in CD than in UC patients. Therefore, the types and numbers of bacteria associated with biopsy samples were distinctly different for UC and CD patients. The observations made in this study should permit targeting of specific bacteriological abnormalities in investigations of the pathogenesis of inflammatory bowel diseases and provide targets for medical interventions. PMID:16849736

Bibiloni, Rodrigo; Mangold, Marco; Madsen, Karen L; Fedorak, Richard N; Tannock, Gerald W

2006-08-01

162

[Complications of transrectal biopsy of the prostate].  

PubMed

The aim of the study was to assess frequency of various complications of transrectal multifocal biopsy of the prostate (TMBP), to specify prophylactic measures against such complications. Primary TMBP under US guidance was made in 612 patients (mean age 65.8 years, mean level of PSA 12.6 ng/ml). TMBP complications include: hematuria (220 patients, 35.9%), hemospermia (166 patients, 27.1%), pain in the perineum and the rectum (189, 30.9%), acute prostatitis (21 patients, 3.4%), acute orchiepididymitis (7 patients, 1.1%), acute urine retention (9 patients, 1.5%), long-term rectal hemorrhage (13 patients, 2.1%), loss of consciousness during the biopsy (7 patients, 1.1%). The analysis of TMBP complications leads to the conclusion that adequate preparation of the patients and accurate conduction of the prostatic biopsy technique under US guidance make this invasive manipulation diagnostically effective and safe. PMID:15989026

Pushkar', D Iu; Govorov, A V

2005-01-01

163

Parotid tail pleomorphic adenoma extending to the parapharyngeal space.  

PubMed

Parapharyngeal space tumors are rare, accounting for 0.5% of head and neck neoplasms. Most of them are benign and originate in the salivary glands, especially the pleomorphic adenoma. We presented a 47-year-old man with parotid tail pleomorphic adenoma extending to the parapharyngeal space. The patient applied to our clinic with the complaints of a painless mass on his neck and in his mouth for 3 months. After fine needle aspiration biopsy, the mass was diagnosed as pleomorphic adenoma. The patient was hospitalized and operated in our clinic. As we see in literature review, parapharyngeal space tumors are rare, and most of them are pleomorphic adenomas arising from the deep lobe of the parotid gland and extend into the PPS. PMID:23524806

Polat, Kerem; Do?an, Mansur; Yüce, Salim; Uysal, Ismail Önder; Müderris, Suphi

2013-03-01

164

Parotid Tail Pleomorphic Adenoma Extending to the Parapharyngeal Space  

PubMed Central

Parapharyngeal space tumors are rare, accounting for 0.5% of head and neck neoplasms. Most of them are benign and originate in the salivary glands, especially the pleomorphic adenoma. We presented a 47-year-old male with parotid tail pleomorphic adenoma extending to the parapharyngeal space. The patient applied to our clinic with the complaints of a painless mass on his neck and in his mouth for three months. After fine needle aspiration biopsy the mass was diagnosed as pleomorphic adenoma. The patient hospitalized and operated in our clinic. As we see in literature review parapharyngeal space tumors are rare and most of them are pleomorphic adenomas arising from deep lobe of the parotid gland and extend into the PPS. PMID:23524806

Polat, Kerem; Do?an, Mansur; Yüce, Salim; Uysal, ?smail Önder; Müderris, Suphi

2012-01-01

165

Radiofrequency Cauterization with Biopsy Introducer Needle  

PubMed Central

PURPOSE The principal risks of needle biopsy are hemorrhage and implantation of tumor cells in the needle tract. This study compared hemorrhage after liver and kidney biopsy with and without radiofrequency (RF) ablation of the needle tract. MATERIALS AND METHODS Biopsies of liver and kidney were performed in swine through introducer needles modified to allow RF ablation with the distal 2 cm of the needle. After each biopsy, randomization determined whether the site was to undergo RF ablation during withdrawal of the introducer needle. Temperature was measured with a thermistor stylet near the needle tip, with a target temperature of 70°C–100°C with RF ablation. Blood loss was measured as grams of blood absorbed in gauze at the puncture site for 2 minutes after needle withdrawal. Selected specimens were cut for gross examination. RESULTS RF ablation reduced bleeding compared with absence of RF ablation in liver and kidney (P < .01), with mean blood loss reduced 63% and 97%, respectively. Mean amounts of blood loss (±SD) in the liver in the RF and no-RF groups were 2.03 g ± 4.03 (CI, 0.53–3.54 g) and 5.50 g ± 5.58 (CI, 3.33–7.66 g), respectively. Mean amounts of blood loss in the kidney in the RF and no-RF groups were 0.26 g ± 0.32 (CI, ?0.01 to 0.53 g) and 8.79 g ± 7.72 (CI, 2.34–15.24 g), respectively. With RF ablation, thermal coagulation of the tissue surrounding the needle tract was observed. CONCLUSION RF ablation of needle biopsy tracts reduced hemorrhage after biopsy in the liver and kidney and may reduce complications of hemorrhage as well as implantation of tumor cells in the tract. PMID:14963187

Pritchard, William F.; Wray-Cahen, Diane; Karanian, John W.; Hilbert, Stephen; Wood, Bradford J.

2014-01-01

166

Integrated laser-guided CT biopsy.  

PubMed

The diagnostic yield of computed tomography (CT)-guided biopsies is dependent on accurate needle insertion. A laser-assisted angle selection system was custom fabricated and used during a CT-guided lung biopsy. Off-target error was measured comparing standard methods to the laser method while pointing towards the target from the skin. The difference between the planned angle and selected angle using the laser-assisted system was 2°, improved from 12° with the standard method. Although yet to be confirmed, laser-assisted angle selection systems may improve the accuracy of needle placement, which may translate into improved outcomes for certain needle based procedures. PMID:24035262

Hong, Cheng William; Xu, Sheng; Imbesi, Kimberly L; Wood, Bradford J

2013-01-01

167

Progress in tail rotor noise analysis  

Microsoft Academic Search

Helicopter tail rotor noise generated by interactions with the main rotor tip vortices and with the fuselage separation mean wake is investigated. The tail rotor blade-main rotor tip vortex interaction is modeled as an airfoil of infinite span cutting through a moving vortex. The present results are compared to the tail rotor loading and high speed thickness noise and are

S.-T. Chou; A. R. George

1986-01-01

168

Physical space and long-tail markets  

Microsoft Academic Search

The Internet is known to have had a powerful impact on on-line retailer strategies in markets characterised by long-tail distribution of sales [C. Anderson, Long Tail: Why the Future of Business is Selling Less of More, Hyperion, New York, 2006]. Such retailers can exploit the long tail of the market, since they are effectively without physical limit on the number

R. Alexander Bentley; Mark E. Madsen; Paul Ormerod

2009-01-01

169

Natural Carbon Sequestration in Mine Tailings  

Microsoft Academic Search

We have documented active sequestration of atmospheric carbon dioxide (CO2) in chrysotile mine tailings at Clinton Creek, Yukon and Cassiar, British Columbia. Hydrated magnesium carbonate minerals develop in mine tailings as a natural consequence of the weathering process within the residues. Magnesium, leached from minerals, reacts with dissolved CO2 in rainwater, precipitating carbonates at the surface of tailings upon evaporation

S. A. Wilson; G. M. Dipple; M. Raudsepp; R. G. Anderson

2005-01-01

170

Comparison of echocardiography-guided and fluoroscopy-guided endomyocardial biopsy techniques.  

PubMed

The accuracy of bioptome placement for endomyocardial biopsy was evaluated using standard fluoroscopic guidance and compared simultaneously with two-dimensional echocardiography in six healthy subadult grizzly bears (Ursus arctos horribilis). Despite perceived adequate positioning of the bioptome toward the septum when judged using fluoroscopy, only one out of the six placements were actually positioned in the right ventricular apex toward the septum when evaluated using two-dimensional echocardiography. The bioptome was readily relocated to the right ventricular apex/septal location by echocardiography. The forceps were easily visualized at all times and the open cups were readily directed into the desired location for biopsy. Based on a subjective score for tissue quantity from 1 to 4 (poor to excellent), biopsies collected by echocardiographic-guided technique had a mean score of 3.4, while biopsies collected by fluoroscopic-guided technique had a mean score of 1.8. In summary, this study suggests that endomyocardial biopsy locations can be accurately positioned using two-dimensional echocardiography with the advantages of less radiation, lower procedural costs, and direct visualization of the sampling site. Clear definition of endocardial surface as afforded by echocardiography may enhance tissue sample quality and lower potential complications from this procedure. PMID:15869156

Nelson, O Lynne; Robbins, Charles T

2005-01-01

171

Diagnosis of Mycoplasma pneumoniae Infection in Autopsy and Open-Lung Biopsy Tissues by Nested PCR  

Microsoft Academic Search

A nested PCR specific for the Mycoplasma pneumoniae P1 gene was used to diagnose mycoplasma infection in two cohort patients with severe pneumonia within 24 h of tissue receipt. A postmortem diagnosis of M. pneumoniae infection was obtained for the first patient, who died without the collection of appropriate paired samples for serodiagnosis. An open-lung biopsy obtained from the second

DEBORAH F. TALKINGTON; W. LANIER THACKER; DAVID W. KELLER; JØRGEN S. JENSEN

1998-01-01

172

Uranium mill tailings quarterly report, January-March 1982  

SciTech Connect

Progress is reported on: radon barrier systems for uranium mill tailings; liner evaluation for uranium mill tailings; revegetation/rock cover for stabilization of inactive U-tailings sites; and application of long-term chemical biobarriers for uranium tailings.

Latkovich, J.M. (comp.)

1982-05-01

173

Parelaphostrongylus odocoilei in Columbian black-tailed deer from Oregon.  

PubMed

Documenting the occurrence of Parelaphostrongylus odocoilei has historically relied on the morphological examination of adult worms collected from the skeletal muscle of definitive hosts, including deer. Recent advances in the knowledge of protostrongylid genetic sequences now permit larvae to be identified. Dorsal-spined larvae (DSLs) collected in 2003-2004 from the lung and feces of six Columbian black-tailed deer (Odocoileus hemionus columbianus) from Oregon were characterized genetically. The sequences from unknown DSLs were compared to those from morphologically validated adults and larvae of P. odocoilei at both the second internal transcribed spacer (ITS-2) of ribosomal DNA and the mitochondrial cytochrome oxidase II gene. We provide the first unequivocal identification of P. odocoilei in Columbian black-tailed deer from Oregon. The broader geographic distribution, prevalence, and pathology of P. odocoilei are not known in populations of Oregon deer. PMID:17092883

Mortenson, Jack A; Abrams, Arthur; Rosenthal, Benjamin M; Dunams, Detiger; Hoberg, Eric P; Bildfell, Robert J; Green, Richard L

2006-07-01

174

Clinical role of the renal transplant biopsy  

PubMed Central

Percutaneous needle core biopsy is the definitive procedure by which essential diagnostic and prognostic information on acute and chronic renal allograft dysfunction is obtained. The diagnostic value of the information so obtained has endured for over three decades and has proven crucially important in shaping strategies for therapeutic intervention. This Review provides a broad outline of the utility of performing kidney graft biopsies after transplantation, highlighting the relevance of biopsy findings in the immediate and early post-transplant period (from days to weeks after implantation), the first post-transplant year, and the late period (beyond the first year). We focus on how biopsy findings change over time, and the wide variety of pathological features that characterize the major clinical diagnoses facing the clinician. This article also includes a discussion of acute cellular and humoral rejection, the toxic effects of calcineurin inhibitors, and the widely varying etiologies and characteristics of chronic lesions. Emerging technologies based on gene expression analyses and proteomics, the in situ detection of functionally relevant molecules, and new bioinformatic approaches that hold the promise of improving diagnostic precision and developing new, refined molecular pathways for therapeutic intervention are also presented. PMID:22231130

Williams, Winfred W.; Taheri, Diana; Tolkoff-Rubin, Nina; Colvin, Robert B.

2013-01-01

175

Perforation from endoscopic small bowel biopsy.  

PubMed Central

Two patients, having undergone an apparently straightforward endoscopy with small bowel biopsy, developed a perforation. One, who proved to have normal small bowel mucosa, needed laparotomy and suturing of the duodenal perforation. The other, who had coeliac disease, settled with conservative management. PMID:8432444

Scott, B; Holmes, G

1993-01-01

176

Sentinel node biopsy: an in depth appraisal  

Microsoft Academic Search

Sentinel node biopsy (SNB) in primary breast cancer has been taken-up widely to avoid the morbidity attributable to axillary node clearance (ANC). Currently many issues surrounding SNB are undecided. This review summarises why some form of axillary surgery is required and presents data on all aspects of SNB including methodology, clinical results and problems that may delay the introduction of

Andrew H. Strickland; Nicolas Beechey-Newman; Christopher B. Steer; Peter G. Harper

2002-01-01

177

Performance feedback in a spine biopsy simulator  

NASA Astrophysics Data System (ADS)

A surgical simulator for needle biopsy of the spine is being developed in the Radiology Department at Georgetown University Medical Center to assist in learning the procedure as well as to maximize accuracy and efficiency. Spine biopsies are often done under computed tomography (CT) guidance and while this technique is effective, it can be time consuming since the biopsy needle must be advanced slowly and its position checked several times to ensure vital organs are not damaged. Quantifying performance during simulation will allow accurate feedback tot eh surgeon as well as the design engineers. Quantifying performance during simulation will allow accurate feedback to the surgeon as well as the design engineers. Performance measures are also important to determine transfer of simulator training skills to actual surgical skills. The simulation protocol is in advanced development, and the steps include selecting the best CT slice for viewing the lesion, choosing the skin entry point, and advancing the needle to the biopsy location. Our methods for developing the system include the following: 1) A task analysis, which produces a detailed list of tasks needed to complete a goal, their order, and time to completion, 2) A function allocation assessment, which identifies critical task components with the goal of relieving the human workload by a reallocation of system functions, and 3) A simulator evaluation through subjective ratings and objective human performance measures.

Lathan, Corinna E.; Cleary, Kevin R.

1998-06-01

178

What Makes a Tidal Tail?  

NASA Astrophysics Data System (ADS)

Galaxy interactions are famous for creating some of the most visually stunning scenes in astronomy, particularly in the cases of tidal tails. These chaotic regions are known to house breeding grounds for young stellar clusters, as shown through past imaging and spectroscopic studies, but the underlying material remains a mystery. While we know that gas is easily stripped from the parent galaxies, what about the stars? The presence of an older stellar population is crucial to dynamical simulations of tidal tails, but has not yet been confirmed by observation. We use the twin tidal tails of NGC3256 as a case study for determining the presence of an old, underlying stellar population. Newly acquired ugriz Gemini data allows us to distinguish between young and old stars, while previous HST data pinpoints the locations of these objects. Deep imaging surveys have often been used to detect tidal features, including these ancient relics, but our survey will be the first to measure the colors of such objects. This will lead us to place constraints on the original composition of the material that was ejected from the interacting/merging galaxies, and the star formation history.

Rodruck, Michael; Konstantopoulos, I.; Charlton, J. C.

2014-01-01

179

Image-Guided Percutaneous Splenic Biopsy and Drainage  

PubMed Central

Percutaneous splenic biopsy and drainage are relatively safe and accurate procedures. The risk of major complication (1.3%) following percutaneous splenic biopsy does not exceed that of other solid intra-abdominal organ biopsies, and it has less morbidity and mortality than splenectomy. Both computed tomography and ultrasound can be used to provide image guidance for biopsy and drainage. The safety profile of fine-needle aspiration cytology is better than core needle biopsy, but core biopsy has superior diagnostic accuracy. PMID:24293803

Sammon, Jennifer; Twomey, Maria; Crush, Lee; Maher, Michael M.; O'Connor, Owen J.

2012-01-01

180

Survival patterns in white-tailed and mule deer after oral inoculation with a standardized, conspecific prion dose.  

PubMed

We orally inoculated white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) with a standardized, conspecific prion dose and collected biologic samples throughout the disease course. Mule deer (PRNP genotype 225SS) and PRNP genotype 96GG white-tailed deer succumbed along similar trajectories, but 96GS- and 96SS-genotype individuals tended to survive longer. PMID:22493138

Miller, Michael W; Wolfe, Lisa L; Sirochman, Tracey M; Sirochman, Michael A; Jewell, Jean E; Williams, Elizabeth S

2012-04-01

181

Endoparasites of Northern Sharp-Tailed Grouse, Tympanuchus phasianellus phasianellus, as Related to Age and Position on the Lek  

Microsoft Academic Search

The only indication of endoparasites found in male sharp-tailed grouse collected during the breeding season from the western James Bay region of northern Ontario, Canada, were nematode eggs of an unknown species. Nematode egg loads of male sharp-tailed grouse that occupied central territories on leks (mating areas) were not significantly different from those o f birds in peripheral territories, nor

LEONARD J. S. TSUJI

182

The potential acid-producing capacity and factors controlling oxidation tailings in the Guryong mine, Korea  

NASA Astrophysics Data System (ADS)

A detailed characterization of the site is crucial to designing an efficient method of managing the risks associated with tailings from abandoned mines. Therefore, samples collected from various depths within tailings in Guryong mine, Korea, were analyzed for their chemical, physical and mineralogical characteristics. All samples of the Guryong tailings had acid-generating potential. However, in the oxidation zone, the net acid generation (NAG) was low (30 kg H2SO4 t-1) although the acid neutralization potential (ANP) was less than zero. The ANP values in the unoxidation zone were higher (> -56.0 kg CaCO3 t-1) than in the other zones. As a result, the amount of alkali ions that are needed to neutralize the acid needs to be considered. In this experiment G3, G4 and G6 drill cores containing fine tailings particles near the unoxidation zone were observed to contain calcite (CaCO3) with acid-neutralizing capacity. A low pH (2-4) in the oxidation zone of the tailings changed to a neutral pH in the unoxidation zone of the tailings. These results suggest that the acid-neutralizing capacity of the tailings was controlled by particle and mineral composition of tailings.

Moon, Yonghee; Song, Yungoo; Moon, Hi-Soo

2008-02-01

183

The hydrogeology of a tailings impoundment formed by central discharge of thickened tailings: implications for tailings management  

NASA Astrophysics Data System (ADS)

The Kidd Creek Cu-Zn sulfide mine is located near Timmins, Ontario. Mill tailings are thickened and deposited as a slurry in a circular impoundment with an area of approximately 1200 ha. Deposition of tailings as a thickened slurry from a central discharge ramp results in a conical-shaped tailings deposit with low perimeter dykes, a uniform grain-size distribution, uniform and low hydraulic conductivity, and a tension-saturated zone above the water table up to 5 to 6 m thick. These characteristics provide benefits over conventionally disposed tailings with respect to tailings management. The thick tension-saturated zone within the tailings limits the thickness of unsaturated tailings that are susceptible to rapid sulfide oxidation. The conical shape of the deposit results in the formation of a recharge area near the centre of the impoundment and discharge in the peripheral areas. In contrast, the elevated nature of many conventional, unthickened tailings impoundments results in recharge over most of the surface of the impoundment, with discharge occurring outside the impoundment through large containment dykes. Three-dimensional pore water flow modelling suggests that approximately 90% of the total discharge from the thickened tailings occurs within the tailings impoundment. When discharge is confined within the impoundment, there is improved control over low-quality effluent, and an opportunity to design passive control measures to reduce treatment costs and minimize environmental impacts.

Al, Tom A.; Blowes, David W.

1999-06-01

184

Arsenic mobility in soils impacted by tailings at Zimapán, México  

NASA Astrophysics Data System (ADS)

The Zimapán mining zone, in Central México is one of the worldwide sites known for As contamination. For more than 20 years and until recently, As-rich groundwater, mainly due to mineralization in a limestone aquifer, was an important source of As exposure to the inhabitants. In addition, decades of ore processing have produced hazardous wastes (tailings), many of them settled in the town outskirts. Although mineralogical and chemical differences exist among the various deposits; every one has high As contents (up to several thousands mg/kg) and other toxic elements that may be released to the nearby soils. To assess As mobility in soils impacted by tailings, total and sequential fractionation determinations were performed in 120 superficial and 40 cm depth samples collected at various distances near three of the impoundments. Higher total As concentrations were measured in the dry (up to 51,534 mg/kg) with respect to the rainy season (up to 23,570 mg/kg) indicating the occurrence of As wash off by rain. Although concentrations were lower in the deep regarding the superficial samples at most sites, As contents reached several thousands mg/kg at 40 cm depth indicating also its vertical transport that may reach the shallow aquifer. Sequential extractions showed differences between soils impacted by highly oxidized (red) tailings and low oxidized (gray) deposits. Most of the As occurs in the Fe-Mn oxides fraction (up to 92%) followed by the organic matter and sulfides fraction (up to 52 %) in soils close to red tailings, while organic matter and sulfide fraction contain most of the As (up to 95%) in soil samples close to low-oxidized deposits. Arsenic proportion in the residual fraction increased with distance from oxidized tailings. Low pH values (from 2.0 to 2.5) in superficial soils revealed the influence of acid mine drainage at distances up to 40 m from the red deposit. In contrast, the lowest pH was 7.1 in soils impacted by low-oxidized deposits, reflecting the limestone environment. Arsenic airborne transport was evidenced by the presence of a total As concentration of 30,780 mg/kg in soils collected at 120 m in front of the tailings crossing a ravine. Although sequential extraction showed that most of the As is present in relatively low-mobility fractions, total As concentrations indicate that tailings impoundments constitute another source of environmental As exposure.

Aurora Armienta, M.; Resendiz, Isabel; Múgica, Violeta; Cruz, Olivia; Aguayo, Alejandra; Ceniceros, Nora

2014-05-01

185

Fine-needle biopsy of the pancreas: Results of 204 routinely performed biopsies in 190 patients  

Microsoft Academic Search

Two-hundred and four fine-needle aspiration biopsies of the pancreas have been performed in 190 patients during a 12-year period. Sixty-one of these were performed percutaneously guided by endoscopic retrograde cholangio-pancreatography, percutaneous transhepatic cholangiography, angiography, or ultrasonography; and 143 were taken intraoperatively. In 77 (67%) out of 115 patients with pancreatic cancer, a correct cytological diagnosis was obtained. Two biopsies were

Odd Søreide; Elsa Skaarland; Ole M. Pedersen; Trond B. Larssen; Bo Arnesjø

1985-01-01

186

Percutaneous Breast Biopsy: Effect on Short-term Quality of Life  

PubMed Central

Purpose To examine the effects of percutaneous breast biopsy on short-term quality of life. Materials and Methods The institutional review board approved this HIPAA-compliant prospective study. From December 1, 2007, through February 28, 2010, women undergoing percutaneous breast biopsy in an academic medical center were recruited to participate in a mixed-mode survey 2–4 days after biopsy. Patients described their biopsy experience by using the Testing Morbidities Index (TMI), a validated instrument for assessing short-term quality of life related to diagnostic testing. The scale ranged from 0 (worst possible experience) to 100 (no adverse effects). Seven attributes were assessed: pain or discomfort before and during testing, fear or anxiety before and during testing, embarrassment during testing, and physical and mental function after testing. Demographic and clinical information were also collected. Univariate and multivariate linear regression analyses were performed to identify significant predictors of TMI score. Results In 188 women (mean age, 51.4 years; range, 22–80 years), the mean TMI score (±standard deviation) was 82 ± 12. Univariate analysis revealed age and race as significant predictors of the TMI score (P < .05). In the multivariate model, only patient age remained a significant independent predictor (P = .001). TMI scores decreased by approximately three points for every decade decrease in patient age, which suggests that younger women were more adversely affected by the biopsy experience. Conclusion Younger patient age is a significant predictor of decreased short-term quality of life related to percutaneous breast biopsy procedures. Tailored prebiopsy counseling may better prepare women for percutaneous biopsy procedures and improve their experience. © RSNA, 2013 PMID:24471385

Humphrey, Kathryn L.; Donelan, Karen; Kong, Chung Y.; Williams, Olubunmi; Itauma, Omosalewa; Halpern, Elkan F.; Gerade, Beverly J.; Rafferty, Elizabeth A.; Swan, J. Shannon

2014-01-01

187

Field investigations and laboratory simulation of clogging in Lixi tailings dam of Jinduicheng, China  

Microsoft Academic Search

Clogging is one of the most important factors affecting the stability of the tailings dams. Firstly, this work investigates the clogging materials of Lixi tailings dam using ICP-AES, X-ray powder diffraction (XRD) and SEM analysis methods. The ICP-AES results indicate that Fe is the dominant element in the clogging materials. The iron contents of clogging samples collected from 2# radial-well

Jun Wu; Yanqing Wu; Jian Lu; Leonora Lee

2007-01-01

188

21 CFR 876.1075 - Gastroenterology-urology biopsy instrument.  

...2014-04-01 false Gastroenterology-urology biopsy instrument. 876.1075 Section...MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Diagnostic Devices § 876.1075 Gastroenterology-urology biopsy instrument. (a)...

2014-04-01

189

21 CFR 876.1075 - Gastroenterology-urology biopsy instrument.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 false Gastroenterology-urology biopsy instrument. 876.1075 Section...MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Diagnostic Devices § 876.1075 Gastroenterology-urology biopsy instrument. (a)...

2013-04-01

190

21 CFR 876.1075 - Gastroenterology-urology biopsy instrument.  

Code of Federal Regulations, 2011 CFR

...2011-04-01 false Gastroenterology-urology biopsy instrument. 876.1075 Section...MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Diagnostic Devices § 876.1075 Gastroenterology-urology biopsy instrument. (a)...

2011-04-01

191

21 CFR 876.1075 - Gastroenterology-urology biopsy instrument.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 false Gastroenterology-urology biopsy instrument. 876.1075 Section...MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Diagnostic Devices § 876.1075 Gastroenterology-urology biopsy instrument. (a)...

2010-04-01

192

21 CFR 876.1075 - Gastroenterology-urology biopsy instrument.  

Code of Federal Regulations, 2012 CFR

...2012-04-01 false Gastroenterology-urology biopsy instrument. 876.1075 Section...MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Diagnostic Devices § 876.1075 Gastroenterology-urology biopsy instrument. (a)...

2012-04-01

193

The hydrogeology of a tailings impoundment formed by central discharge of thickened tailings: implications for tailings management  

Microsoft Academic Search

The Kidd Creek Cu–Zn sulfide mine is located near Timmins, Ontario. Mill tailings are thickened and deposited as a slurry in a circular impoundment with an area of approximately 1200 ha. Deposition of tailings as a thickened slurry from a central discharge ramp results in a conical-shaped tailings deposit with low perimeter dykes, a uniform grain-size distribution, uniform and low

Tom A Al; David W Blowes

1999-01-01

194

BACTEC FX system as a tool for culturing gastric biopsies and Helicobacter pylori diagnosis.  

PubMed

Helicobacter pylori infection represents a key factor in the etiology of various gastrointestinal diseases. There are several acceptable methods to identify this microorganism. Some are invasive and some are noninvasive. This study demonstrates the use of BACTEC FX system for the growth and diagnosis of H. pylori isolated from gastric biopsy specimens, cut and placed in blood culture bottles, with subsequent incubation in the apparatus. Twenty-five positive and 15 negative biopsy samples tested using the quick urease technique, CUTest, were collected from 40 patients with confirmed chronic gastric inflammation. The biopsy samples were manually cut using a sterile scalpel and placed in tubes containing 5 ml of fetal bovine serum. The resulting suspensions were transferred using a syringe into anaerobic blood culture bottles. These bottles were incubated at 35 °C for a period of 7 days in the BACTEC FX system. All biopsy samples that reacted positive to the CUTest and one biopsy sample that reacted negative to the CUTest were confirmed as positive by the BACTEC FX system. In addition, there was a correlation between the positive culture and histology examination results. The use of BACTEC FX system significantly shortens the time needed for culturing, which makes the system more efficient in the identification of H. pylori. It should be emphasized that performing microbial culture testing has a significant role in monitoring antibiotic resistance, which cannot be done using other existing methods for H. pylori diagnosis. PMID:23793256

Peretz, A; On, A; Koiefman, H; Brodsky, D; Isakovich, N; Glyatman, T; Paritsky, M

2013-12-01

195

Measuring optical properties of microvolume biopsies  

NASA Astrophysics Data System (ADS)

Special tissue sampler was developed, allowing measuring concentration of photosensitizer in various biopsy materials with high accuracy. The method is based on simultaneous measurement of fluorescence and reflectance spectra and biopsy of tissue sample embedded in a spherical aperture by a diameter of 1.5 mm and a depth of 1 mm. Both surfaces of the sampler were covered with an impenetrable black film. Meterological measurements were done on standard solutions consisting solutions "Photoscence" and "Intralipid" in various ratios. We used a fiber optic spectrometer LESA-01-BIOSPEC to measure optical properties of the solution with various concentrations of "Intralipid" and "Photoscence." Results follow theory. To measure concentration of photosensitizer in micro volumes and thin layers, special multifiber catheters with external diameter from 0.5 mm to 1.8 mm were prepared.

Taraz, Majid; Loschenov, Victor B.

2004-07-01

196

Achromatized endomicroscope objective for optical biopsy  

PubMed Central

Currently, researchers and clinicians lack achromatized endomicroscope objectives that are as narrow as biopsy needles. We present a proof-of-concept prototype that validates the optical design of an NA0.4 objective. The objective, built with plastic lenses, has a 0.9 mm clear aperture and is achromatized from 452 nm to 623 nm. The objective’s measured Strehl ratio is 0.74 ± 0.05 across a 250 ?m FOV. We perform optical sectioning via structured illumination through the objective while capturing fluorescence images of breast carcinoma cells stained with proflavine and cresyl violet. This technology has the potential to improve optical biopsies and provide the next step forward in cancer diagnostics. PMID:23412009

Kyrish, Matthew; Tkaczyk, Tomasz S.

2013-01-01

197

Achromatized endomicroscope objective for optical biopsy.  

PubMed

Currently, researchers and clinicians lack achromatized endomicroscope objectives that are as narrow as biopsy needles. We present a proof-of-concept prototype that validates the optical design of an NA0.4 objective. The objective, built with plastic lenses, has a 0.9 mm clear aperture and is achromatized from 452 nm to 623 nm. The objective's measured Strehl ratio is 0.74 ± 0.05 across a 250 ?m FOV. We perform optical sectioning via structured illumination through the objective while capturing fluorescence images of breast carcinoma cells stained with proflavine and cresyl violet. This technology has the potential to improve optical biopsies and provide the next step forward in cancer diagnostics. PMID:23412009

Kyrish, Matthew; Tkaczyk, Tomasz S

2013-02-01

198

Rectal biopsy findings in infantile neuroaxonal dystrophy.  

PubMed

A 21-month-old boy with a family history of parental consanguinity and two siblings having died of a progressive neurological disorder was investigated for a neurometabolic disease because of recent loss of gait and lack of intellectual progress. While a lysosomal disease could not be verified, his clinical findings were compatible with infantile neuroaxonal dystrophy, the diagnosis of which was electron microscopically established by demonstrating typical enlarged axonal terminals in rectal biopsy tissue. PMID:7207709

Goebel, H H; Kohlschütter, A; Schulte, F J

1980-11-01

199

Infantile neuroaxonal dystrophy: diagnosis by skin biopsy.  

PubMed

A child who shows progressive motor and mental deterioration after the first year of life, who has pyramidal signs, marked muscle hypotonia, but no seizures, suggests to have infantile neuroaxonal dystrophy (INAD). Beyond the age of two years, the EEG also entails characteristic findings. Diagnosis may be obtained by an ultrastructural examination of biopsied skin. The respective clinical and morphological findings are recorded and illustrated from four patients in this report. PMID:1659791

Ozmen, M; Cali?kan, M; Goebel, H H; Apak, S

1991-07-01

200

FOODS OF THE AUSTRALIAN BRUSH-TAILED OPOSSUM (TRICHOSURUS VULPECULA) IN AN EXOTIC FOREST  

Microsoft Academic Search

SUMMARY: Foods of the Australian Brush-tailed opossum, Trichosurus vulpecula, were identified from stomach contents of 360 opossums collected from May 1975 to May 1976 in Ashley State Forest, Canterbury, New Zealand. Plant species eaten were identified with the aid of reference cuticles prepared from known plant species collected from the study area. Thirty different foods were identified, but only seven

B. WARBURTON

201

Aspiration biopsy cytology in diagnosis of thyroid cancer  

Microsoft Academic Search

Aspiration biopsy cytology (ABC) is a diagnostic method that has been used extensively in Sweden for a quarter of a century. The technical steps involved in this biopsy procedure are described, and the differences from large needle biopsy techniques are pointed out. An overview is given of the different pathologic conditions that present as thyroid nodules and are recognizable by

Torsten Löwhagen; Jan-Silvester Willems; Göran Lundell; Rolf Sundblad; Per-Ola Granberg

1981-01-01

202

Initial experience with the advanced breast biopsy instrumentation system  

Microsoft Academic Search

Background: Advanced breast biopsy instrumentation is a recently designed alternative to large-core stereotactic and open needle localized breast biopsies. This minimally invasive technique uses digital stereotactic imaging to perform excisional biopsies of suspicious, nonpalpable mammographic lesions. The role of the ABBI system in the management of breast cancer has not yet been defined.Methods: A retrospective review to evaluate the safety,

Brent D Matthews; Gary B Williams

1999-01-01

203

Value of Sentinel Lymph Node Biopsy in Breast Cancer Patients with Previous Excisional Biopsy  

PubMed Central

Purpose Sentinel lymph node biopsy (SLNB) in breast cancer patients with clinically negative axilla will ensure axillary dissection only for cases with lymph node metastasis and provide information about pathologic staging as accurate as the axillary dissection. It was shown that SLNB could be successfully performed regardless of the type of biopsy. The aim of this study was to investigate the feasibility of SLNB after excisional biopsy. Methods One hundred patients diagnosed with excisional biopsy or guide wire-localization and operated on with SLNB between February 2007 and March 2009 were retrospectively analyzed. SLNB was performed with 10 cc of 1% methylene blue alone or both methylene blue and 1 mCi of Tc-99m nanocolloid combination. Age, tumor localization and size, length of the biopsy incision, size of the biopsy specimen, multifocality, lymphovascular invasion, tumor grade, staining with methylene blue, localization, number and metastatic status of the lymph nodes stained, and success rate with a gamma probe were evaluated. Results Sentinel lymph node (SLN) could not be identified in 9 (16.9%) of patients in the methylene blue group (n=53). In the combination group (n=47), SLN could not be identified in one patient. Of 32 patients with negative SLNB, metastatic involvement was found to be present in 5 patients after axillary lymph node dissection (false negatives). The average numbers of SLNs found in the methylene blue group and combination group were 1.4 and 1.6, respectively. SLN detection and false negative rates in the methylene blue group were 83% and 15.7%, respectively. The rates for the combination group were 98% and 6.4%, respectively. None of the parameters related to patient, tumor or process were found to affect detection rates of SLN. Conclusion Only SLNB using a combination method is a safe and reliable technique for breast cancer patients diagnosed with excisional biopsy. PMID:22493633

Coskun, Gokhan; Dogan, Lutfi; Ozaslan, Cihangir; Atalay, Can

2012-01-01

204

Evaluation of formalin-fixed ileum as the optimum method to diagnose equine dysautonomia (grass sickness) in simulated intestinal biopsies.  

PubMed

Equine dysautonomia, or grass sickness, is a frequently fatal disease of unknown etiology, manifested as poor gastrointestinal motility and colic as a result of degenerative changes in the autonomic nervous system. Examination of ileal biopsies collected at laparotomy is currently the best antemortem diagnostic method to distinguish equine dysautonomia from colic cases, which can present with similar signs, but their value has not been previously critically evaluated. Using simulated biopsies collected postmortem from 23 cases of equine dysautonomia and 11 of colic, the sensitivity and specificity of 1-cm long, formalin-fixed ileal biopsies was 100% for the diagnosis of equine dysautonomia. There was therefore no advantage to using larger biopsies or examining jejunum either in addition to or instead of ileal biopsies. Furthermore, although cryostat sections of ileum, 1-cm long, had a sensitivity of 100%, the specificity was only 73%, meaning that 27% of cases would have been misclassified, resulting in unnecessary euthanasia. Increasing the size of the cryostat or examining jejunum in addition to ileum cryostat sections did not significantly improve the specificity. Results of the current study indicate that in diagnostic practice, 1-cm long, formalin-fixed biopsies are likely to be the most suitable for accurate diagnosis, despite the slower turnaround time compared with cryostat sections. PMID:20224086

Milne, Elspeth M; Pirie, R Scott; McGorum, Bruce C; Shaw, Darren J

2010-03-01

205

Active tails enhance arboreal acrobatics in geckos.  

PubMed

Geckos are nature's elite climbers. Their remarkable climbing feats have been attributed to specialized feet with hairy toes that uncurl and peel in milliseconds. Here, we report that the secret to the gecko's arboreal acrobatics includes an active tail. We examine the tail's role during rapid climbing, aerial descent, and gliding. We show that a gecko's tail functions as an emergency fifth leg to prevent falling during rapid climbing. A response initiated by slipping causes the tail tip to push against the vertical surface, thereby preventing pitch-back of the head and upper body. When pitch-back cannot be prevented, geckos avoid falling by placing their tail in a posture similar to a bicycle's kickstand. Should a gecko fall with its back to the ground, a swing of its tail induces the most rapid, zero-angular momentum air-righting response yet measured. Once righted to a sprawled gliding posture, circular tail movements control yaw and pitch as the gecko descends. Our results suggest that large, active tails can function as effective control appendages. These results have provided biological inspiration for the design of an active tail on a climbing robot, and we anticipate their use in small, unmanned gliding vehicles and multisegment spacecraft. PMID:18347344

Jusufi, Ardian; Goldman, Daniel I; Revzen, Shai; Full, Robert J

2008-03-18

206

Characteristics of wing/body/tail configurations  

NASA Technical Reports Server (NTRS)

Package of computer programs determine longitudinal aerodynamic characteristics of wing/body/tail combinations including effects of nonlinear aerodynamics of components and interference between components.

Dillenius, M. F. E.; Goodwin, F. K.; Kline, D. M.; Mendenhall, M. R.

1979-01-01

207

Tests for the Elimination of Tail Flutter  

NASA Technical Reports Server (NTRS)

On various low-wing monoplanes the horizontal tail surfaces flutter in flight at large angles of attack and occasionally in curvilinear flight. This flutter leads to torsional vibrations of the rear end of the fuselage, as manifested by vibrations of the control stick. According to the earlier DVL investigations tail flutter is due to the influence, on horizontal tail surfaces, of eddies or vortices shed at large angles of attack by the upper surface of the wing root. The cause of tail flutter on a low-wing monoplane and the means of preventing it are investigated in the present report.

Biechteler, Curt

1933-01-01

208

Infantile neuroaxonal dystrophy: axonal changes in biopsied muscle tissue.  

PubMed

Dystrophic axons were found in the biopsied muscle tissue of a 17-month-old hypotonic infant after confirmation of a diagnosis of infantile neuroaxonal dystrophy (INAD) by subsequent peripheral nerve biopsy. He manifested gradual deterioration and had brief tonic seizures. The sural nerve biopsy, performed at age 42 months, confirmed INAD. Intensive ultrastructural investigation of the preceding muscle biopsy specimens demonstrated infrequent but definite findings of axonal degeneration in the musculature. Ultrastructural investigation of muscle biopsy should include a careful search for neural tissue because in INAD axonal changes occur primarily in the presynaptic region. PMID:8216545

Wakai, S; Asanuma, H; Tachi, N; Ishikawa, Y; Minami, R

1993-01-01

209

Accuracy analysis in MRI-guided robotic prostate biopsy  

PubMed Central

Purpose To assess retrospectively the clinical accuracy of an magnetic resonance imaging-guided robotic prostate biopsy system that has been used in the US National Cancer Institute for over 6 years. Methods Series of 2D transverse volumetric MR image slices of the prostate both pre (high-resolution T2-weighted)-and post (low-resolution)-needle insertions were used to evaluate biopsy accuracy. A three-stage registration algorithm consisting of an initial two-step rigid registration followed by a B-spline deformable alignment was developed to capture prostate motion during biopsy. The target displacement (distance between planned and actual biopsy target), needle placement error (distance from planned biopsy target to needle trajectory), and biopsy error (distance from actual biopsy target to needle trajectory) were calculated as accuracy assessment. Results A total of 90 biopsies from 24 patients were studied. The registrations were validated by checking prostate contour alignment using image overlay, and the results were accurate to within 2 mm. The mean target displacement, needle placement error, and clinical biopsy error were 5.2, 2.5, and 4.3 mm, respectively. Conclusion The biopsy error reported suggests that quantitative imaging techniques for prostate registration and motion compensation may improve prostate biopsy targeting accuracy. PMID:23532560

Lasso, Andras; Guion, Peter; Krieger, Axel; Kaushal, Aradhana; Singh, Anurag K.; Pinto, Peter A.; Coleman, Jonathan; Grubb, Robert L.; Lattouf, Jean-Baptiste; Menard, Cynthia; Whitcomb, Louis L.; Fichtinger, Gabor

2014-01-01

210

Value of repeat biopsy in lupus nephritis flares  

PubMed Central

Objectives Renal flares are common in lupus nephritis (LN), and class switch is thought to be characteristic. There is no agreement on indications for performing a repeat renal biopsy. Our objective was to retrospectively review patients who had more than one renal biopsy performed on clinical indications, and analyse clinical, pathological and treatment changes after successive biopsies. Methods Forty-five patients with LN and one or more repeat renal biopsies were included, with a total of 116 biopsies. Results Of the 71 repeat biopsies, pathological transition occurred in 39 (54.9%). When having a previous biopsy with a proliferative lesion, class switch occurred in 55.6%, with 24.4% evolving into non-proliferative classes. When previous biopsy was class V, transition to other classes occurred in 58.3% and changes were all into proliferative classes. Conversion from one pure proliferative form to another (class III to class IV or vice versa) happened in 11.3% of the rebiopsies, with 62 rebiopsies (87.3%) leading to a change in the treatment regimen. Conclusions Histological transformations were common, and they occurred when the previous biopsy had non-proliferative lesions as well as when lesions were proliferative. Treatments were modified after repeat renal biopsy in the majority of patients. In this experience, kidney repeat biopsies were useful in guiding treatment of LN flares. PMID:25396056

Greloni, G; Scolnik, M; Marin, J; Lancioni, E; Quiroz, C; Zacariaz, J; De la Iglesia Niveyro, P; Christiansen, S; Pierangelo, M A; Varela, C F; Rosa-Diez, G J; Catoggio, L J; Soriano, E R

2014-01-01

211

A generalized female bias for long tails in a short-tailed widowbird.  

PubMed Central

Tail elongation in the polygynous widowbirds (Euplectes spp.) has evoked both adaptive and non-adaptive explanations. Female choice has been shown in the three longest tailed species (20-50 cm), whereas an agonistic function was proposed for a medium-tailed (10 cm) widowbird. To test the generality and directionality of sexual selection on tail length in widowbirds, we experimentally investigated selection in the relatively short-tailed (7 cm) red-shouldered widowbirds (E. axillaris). Prior to territory establishment, males were assigned to four tail-treatment groups; control, short, long and supernormal (similar to a sympatric long-tailed congener). No effects on male competition were detected as the groups were equally successful in acquiring territories of similar size and quality. However, mating success among the 92 territorial males was strongly skewed in favour of supernormal-tailed males (62% of active nests; 5.2 +/- 1.3 nests per territory). Long-tailed males also acquired more nests (1.9 +/- 0.7) than control (0.7 +/- 0.5) and short-tailed (0.5 +/- 0.3) males, while the latter two groups did not differ significantly. These results support a general, open-ended female preference for long tails in widowbirds and may represent a receiver bias that arose early in their divergence from the short-tailed weaverbirds (Ploceinae). PMID:12396489

Pryke, Sarah R; Andersson, Staffan

2002-01-01

212

The significance of atypical lobular hyperplasia at percutaneous breast biopsy.  

PubMed

Atypical lobular hyperplasia (ALH) is occasionally found in specimens obtained by percutaneous stereotactic vacuum-assisted breast biopsy for microcalcifications. Since malignancy is often found at surgical excision when atypical ductal hyperplasia is found at percutaneous biopsy, we reviewed our pathologic findings from surgery for ALH at percutaneous biopsy. This was a retrospective review of all percutaneous breast biopsy specimens for mammographic microcalcifications obtained from a single institution over a 30-month period. The pathologic findings from percutaneous biopsy were correlated with the radiologic appearance and the pathology from surgical excision. ALH was found in 13 of 766 (1.7%) stereotactic vacuum-assisted core needle biopsies performed for mammographic microcalcifications. Subsequent surgery in six patients revealed ductal carcinoma in situ (DCIS) in two patients and one case of invasive ductal carcinoma. Surgical excision is indicated for areas with ALH discovered by percutaneous biopsy for mammographic microcalcifications. PMID:12558664

Dmytrasz, Karen; Tartter, Paul Ian; Mizrachy, Howard; Chinitz, Lynn; Rosenbaum Smith, Sharon; Estabrook, Alison

2003-01-01

213

Dewatering of coal plant tailings: Flocculation followed by filtration  

Microsoft Academic Search

A sustainable alternative to tailings dam disposal of coal refuse is mechanical dewatering of tailings, which provides fast production of dry solids and water reuse. In this study, flocculation followed by filtration of coal plant tailings, a new concept in tailings dewatering is investigated in detail. This paper focuses on the effect of preconditioning tailings with varying flocculants and dosages

Naureen Alam; Orhan Ozdemir; Marc A. Hampton; Anh V. Nguyen

2011-01-01

214

Shifts in microbial community composition and function in the acidification of a lead/zinc mine tailings.  

PubMed

In an attempt to link the microbial community composition and function in mine tailings to the generation of acid mine drainage, we simultaneously explored the geochemistry and microbiology of six tailings collected from a lead/zinc mine, i.e. primary tailings (T1), slightly acidic tailings (T2), extremely acidic tailings (T3, T4 and T5) and orange-coloured oxidized tailings (T6). Geochemical results showed that the six tailings (from T1 to T6) likely represented sequential stages of the acidification process of the mine tailings. 16S rRNA pyrosequencing revealed a contrasting microbial composition between the six tailings: Proteobacteria-related sequences dominated T1-T3 with relative abundance ranging from 56 to 93%, whereas Ferroplasma-related sequences dominated T4-T6 with relative abundance ranging from 28 to 58%. Furthermore, metagenomic analysis of the microbial communities of T2 and T6 indicated that the genes encoding key enzymes for microbial carbon fixation, nitrogen fixation and sulfur oxidation in T2 were largely from Thiobacillus and Acidithiobacillus, Methylococcus capsulatus, and Thiobacillus denitrificans respectively; while those in T6 were mostly identified in Acidithiobacillus and Leptospirillum, Acidithiobacillus and Leptospirillum, and Acidithiobacillus respectively. The microbial communities in T2 and T6 harboured more genes suggesting diverse metabolic capacities for sulfur oxidation/heavy metal detoxification and tolerating low pH respectively. PMID:23574280

Chen, Lin-Xing; Li, Jin-Tian; Chen, Ya-Ting; Huang, Li-Nan; Hua, Zheng-Shuang; Hu, Min; Shu, Wen-Sheng

2013-09-01

215

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting  

PubMed Central

Transrectal ultrasound (TRUS) biopsy can miss 20–30% of clinically significant cancers. We evaluate an alternative approach—transperineal template-guided mapping biopsy (TTMB) in the initial and repeat biopsy setting. From January 2005 through September 2008, 373 consecutive men underwent TTMB (294 men with ?1 prior negative biopsy and 79 men as the initial biopsy). The location of each positive biopsy core, number of positive cores, and percent involvement of each core was recorded. Cancer detection rate for the initial biopsy was 75.9%. For men with 1, 2, and ?3 prior negative biopsies detection rates were 55.5%, 41.7%, and 34.4%, respectively. In all, 55.5% of the cancers identified were Gleason ?7. The majority of the cancers were multifocal. There was no significant change in the number of positive cores or Gleason score as the number of prior biopsies increased. The anterior and apical aspects of the prostate were among the most common cancer locations. TTMB provides a high rate of cancer detection as initial and repeat biopsy. TTMB was particularly effective at diagnosing anterior and apical cancer. TTMB may have particular application for men considering active surveillance, with prior negative TRUS biopsies, and those considering subtotal gland or other minimally invasive treatments. PMID:19786982

Taira, A V; Merrick, G S; Galbreath, R W; Andreini, H; Taubenslag, W; Curtis, R; Butler, W M; Adamovich, E; Wallner, K E

2009-01-01

216

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting.  

PubMed

Transrectal ultrasound (TRUS) biopsy can miss 20-30% of clinically significant cancers. We evaluate an alternative approach-transperineal template-guided mapping biopsy (TTMB) in the initial and repeat biopsy setting. From January 2005 through September 2008, 373 consecutive men underwent TTMB (294 men with > or =1 prior negative biopsy and 79 men as the initial biopsy). The location of each positive biopsy core, number of positive cores, and percent involvement of each core was recorded. Cancer detection rate for the initial biopsy was 75.9%. For men with 1, 2, and > or =3 prior negative biopsies detection rates were 55.5%, 41.7%, and 34.4%, respectively. In all, 55.5% of the cancers identified were Gleason > or =7. The majority of the cancers were multifocal. There was no significant change in the number of positive cores or Gleason score as the number of prior biopsies increased. The anterior and apical aspects of the prostate were among the most common cancer locations. TTMB provides a high rate of cancer detection as initial and repeat biopsy. TTMB was particularly effective at diagnosing anterior and apical cancer. TTMB may have particular application for men considering active surveillance, with prior negative TRUS biopsies, and those considering subtotal gland or other minimally invasive treatments. PMID:19786982

Taira, A V; Merrick, G S; Galbreath, R W; Andreini, H; Taubenslag, W; Curtis, R; Butler, W M; Adamovich, E; Wallner, K E

2010-03-01

217

VARIATION IN THE SHARP-TAILED SPARROWS  

Microsoft Academic Search

In 1995, following Greenlaw (1993), the AOU split the Sharp-tailed Sparrow into two species, the Saltmarsh (Ammodramus caudacutus) and Nelson's (A. nelsoni) Sharp-tailed Sparrows. The former breeds in coastal saltmarshes of the central East Coast, the latter in the northern interior, around the southern coast of Hudson Bay, and along the northeastern seaboard. Both species winter along the southern Atlantic

STEVE N. G. HOWELL; DAVID A. SIBLEY

1998-01-01

218

Modeling river flows with heavy tails  

Microsoft Academic Search

Recent advances in time series analysis provide alternative models for river flows in which the innovations have heavy tails, so that some of the moments do not exist. The probability of large fluctuations is much larger than for standard models. We survey some recent theoretical developments for heavy tail time series models and illustrate their practical application to river flow

Paul L. Anderson; Mark M. Meerschaert

1998-01-01

219

Tail and pelvis pathologies of ankylosaurian dinosaurs  

Microsoft Academic Search

Ankylosaurid dinosaurs had modified distal caudal vertebrae (the handle) and large terminal caudal osteoderms (the knob), which together form the tail club. The tail club may have been used as a weapon. Ankylosaur pelvic and caudal elements were surveyed for evidence of healing wounds that may indicate traumatic injury, and which could support clubbing behaviour. No pathologies were found in

Victoria M. Arbour; Philip J. Currie

2011-01-01

220

Artificial Inoculation—Perspectives in Tailings Phytostabilization  

Microsoft Academic Search

Intensive mining and processing activities worldwide resulted in the generation of huge amounts of waste (tailings), generally characterized as toxic, radioactive, and\\/or hazardous. The exposure potential and, hence, the risk posed by such wastes is enhanced by a general lack of vegetation. Phytostabilization has proven to be efficient in reducing this risk. However, establishing vegetation on tailing dumps may be

Ioana G. Petrisor; Smaranda Dobrota; Kostas Komnitsas; Ioan Lazar; J. Michael Kuperberg; Mihai Serban

2004-01-01

221

Groundwater pollution due to a tailings dam  

Microsoft Academic Search

In 1982, the Oman Mining Company (OMC) commenced copper mining and smelting operations in the area of Sohar (Wadi Suq), Sultanate of Oman. Seawater was used for mining operations until 1993. During this period, 11 million tonnes of tailings had been deposited behind an unlined tailings dam. This has resulted in a major groundwater pollution problem.This paper presents results from

R. S Sharma; T. S Al-Busaidi

2001-01-01

222

On tail estimation: An improved method  

Microsoft Academic Search

A step is described toward better statistical treatment of data for tail estimation. The classical extreme value theory together with its practical inefficiency for tail inference are discussed briefly. The threshold method that utilizes available information in a more efficient manner is described, and its relation to extreme value theory is mentioned. Some comparison is also made using two sets

G. R. Dargahi-Noubary

1989-01-01

223

On the flaring of cometary plasma tails  

NASA Technical Reports Server (NTRS)

Assuming that hypersonic pressure balance with the solar wind governs the shape of plasma tails, it is found that the gas pressure of tail ions and the magnetic field strength at the flanks of the ionopause control the flaring state. The gas pressure exhibits the larger effect: for constant pressures above a certain critical value, the tail flares essentially without limit, while for smaller values the tail flares only near the head (becoming cylindrical at greater distances). The influence of the magnetic field is that the tail flares to larger distances the higher the field strength at the flanks of the ionopause. The observed variability in flaring (and the implied differences in gas pressure and magnetic field) are throught to be the result of changes in the position and shape of the sunward cometary ionopause. Insertion of reasonable comet and solar wind parameters into the pressure balance equations is found to give good agreement with the observations.

Ershkovich, A. I.; Niedner, M. B., Jr.; Brandt, J. C.

1982-01-01

224

The Dust Tail of Asteroid (3200) Phaethon  

NASA Astrophysics Data System (ADS)

We report the discovery of a comet-like tail on asteroid (3200) Phaethon when imaged at optical wavelengths near perihelion. In both 2009 and 2012, the tail appears gsim350'' (2.5 × 108 m) in length and extends approximately in the projected anti-solar direction. We interpret the tail as being caused by dust particles accelerated by solar radiation pressure. The sudden appearance and the morphology of the tail indicate that the dust particles are small, with an effective radius ~1 ?m and a combined mass ~3 × 105 kg. These particles are likely products of thermal fracture and/or desiccation cracking under the very high surface temperatures (~1000 K) experienced by Phaethon at perihelion. The existence of the tail confirms earlier inferences about activity in this body based on the detection of anomalous brightening. Phaethon, the presumed source of the Geminid meteoroids, is still active.

Jewitt, David; Li, Jing; Agarwal, Jessica

2013-07-01

225

Biopsy sampling of breast lesions: comparison of core needle- and vacuum-assisted breast biopsies.  

PubMed

Needle biopsy is now the initial investigation of choice for the pre-operative diagnosis of breast lesions. This includes core needle biopsy (CNB) and vacuum-assisted biopsy (VAB) with or without radiologic assistance. The performance indices of both of these biopsy techniques were evaluated. In a large cohort of patients with breast lesions including 464 cases (285 CNB and 179 VAB), with confirmed outcomes, the diagnostic accuracy was compared using parameters including quantitation of the sampling based on the total number of cores taken, cores containing breast parenchyma, and cores with lesion; and non-epithelial changes including necrosis and calcification. CNB showed a 99% PPV, 94% NPV, 96% sensitivity, and 99% specificity, whereas VAB demonstrated a 100% PPV, 100% NPV, 100% sensitivity, and 100% specificity. The correct diagnosis in CNB was proportional to the number of cores extracted, whereas accuracy of VAB was independent of the total number of cores taken. There was a positive correlation between the presence of calcification and malignancy in CNB, but not detected under VAB. CNB and VAB were equally efficient in palpable lesions, in detecting necrosis, and calcification. Large calcification was found to be associated with malignancy in both CNB and VAB. In non-palpable lesions, VAB was more effective in the detection of calcification. The diagnostic accuracy of VAB appeared to be independent of number of cores sampled, whereas CNB required a minimum of 3-4 cores to achieve high diagnostic accuracy. PMID:21698409

Lacambra, Maribel D; Lam, Christopher C; Mendoza, Paulo; Chan, Siu Ki; Yu, Alex M; Tsang, Julia Y S; Tan, Puay Hoon; Tse, Gary M

2012-04-01

226

Differences in pain perception during open muscle biopsy and Bergstroem needle muscle biopsy  

PubMed Central

Purpose Open surgical muscle biopsy (OB) and percutaneous Bergstroem needle muscle biopsy (NB) are equally accepted procedures. However, there are no data comparing intraprocedural pain for both techniques. We designed this prospective trial to test the hypothesis that the less invasive NB causes less intraprocedural pain than OB. Methods In a two-center prospective trial, 33 patients underwent both procedures in one session. All patients quantified intraprocedural pain using the numeric rating scale (NRS). Mean NRS values were calculated along with the difference in NRS values (?NRS) between both types of biopsies. Results Mean NRS values were 4.5 (±2.7 standard deviation [SD]) for NB and 3.2 (±2.1) for OB (P=0.02). Of the patients, 57.6% described the ?NRS as ?2 NRS points. Regarding the pain categories “mild” (NRS 0–3), “moderate” (NRS 4–7), and “severe” (NRS 8–10), no significant difference was observed between NB and OB. Patients who found NB to be more uncomfortable were more likely to quantify the ?NRS as >2 NRS points than patients finding OB more uncomfortable. Conclusion Our results do not support the hypothesis that intraprocedural pain in NB is less than in OB. When informing the patient about both types of muscle biopsies, the amount of intraprocedural pain should not serve as a differentiating characteristic.

Dengler, Julius; Linke, Peter; Gdynia, Hans J; Wolf, Stefan; Ludolph, Albert C; Vajkoczy, Peter; Meyer, Thomas

2014-01-01

227

Percutaneous renal biopsy of native kidneys: efficiency, safety and risk factors associated with major complications  

PubMed Central

Introduction The use of an automated biopsy device and real-time ultrasound (current technology) for percutaneous renal biopsies (PRBs) has improved the likelihood of obtaining adequate tissue for diagnosis and has reduced the complications associated with renal biopsies. Our objective was to evaluate the efficacy and safety of the current PRB procedure and identify possible risk factors for the development of major complications. Material and methods We collected all native kidney PRBs performed with current technology in our institute from January 1998 to April 2008. Studied variables were collected from the patient's chart at the time of the biopsy. Results We analyzed 623 (96.4%) of 646 renal biopsies performed with the current automated procedure guided by real-time ultrasound. Although the effectiveness was 97.6%, there were 110 complications. Fourteen (2.24%) of these complications were major: 9 cases of renal hematoma, 2 cases with macroscopic hematuria (which needed blood transfusion), 1 case of intestinal perforation (which required exploratory laparotomy), 1 nephrectomy and 1 case of a dissecting hematoma. The logistic regression analysis demonstrated the following risk factors for developing major complications: diastolic blood pressure ? 90 mmHg, RR 7.6 (95% CI 1.35-43); platelet count ? 120×103/µl; RR 7.0 (95% CI 1.9-26.2); and blood urea nitrogen (BUN) ? 60 mg/dl, RR 9.27 (95% CI 2.8-30.7). Conclusions The observed efficacy and safety of the current technique in the present study were similar to observations in previous studies. Diastolic blood pressure ? 90 mmHg, platelets ? 120×103/µl and BUN ? 60 mg/dl were independent risk factors for the development of major complications following PRB. PMID:22291827

Torres Munoz, Abel; Valdez-Ortiz, Rafael; Gonzalez-Parra, Carlos; Espinoza-Davila, Elvy; Morales-Buenrostro, Luis E.; Correa-Rotter, Ricardo

2011-01-01

228

Development of a Nuclear Morphometric Signature for Prostate Cancer Risk in Negative Biopsies  

PubMed Central

Background Our objective was to develop and validate a multi-feature nuclear score based on image analysis of direct DNA staining, and to test its association with field effects and subsequent detection of prostate cancer (PCa) in benign biopsies. Methods Tissue sections from 39 prostatectomies were Feulgen-stained and digitally scanned (400×), providing maps of DNA content per pixel. PCa and benign epithelial nuclei were randomly selected for measurement of 52 basic morphometric features. Logistic regression models discriminating benign from PCa nuclei, and benign from malignant nuclear populations, were built and cross-validated by AUC analysis. Nuclear populations were randomly collected <1 mm or >5 mm from cancer foci, and from cancer-free prostates, HGPIN, and PCa Gleason grade 3–5. Nuclei also were collected from negative biopsy subjects who had a subsequent diagnosis of PCa and age-matched cancer-free controls (20 pairs). Results A multi-feature nuclear score discriminated cancer from benign cell populations with AUCs of 0.91 and 0.79, respectively, in training and validation sets of patients. In prostatectomy samples, both nuclear- and population-level models revealed cancer-like features in benign nuclei adjacent to PCa, compared to nuclei that were more distant or from PCa-free glands. In negative biopsies, a validated model with 5 variance features yielded significantly higher scores in cases than controls (P?=?0.026). Conclusions A multifeature nuclear morphometric score, obtained by automated digital analysis, was validated for discrimination of benign from cancer nuclei. This score demonstrated field effects in benign epithelial nuclei at varying distance from PCa lesions, and was associated with subsequent PCa detection in negative biopsies. Impact This nuclear score shows promise as a risk predictor among men with negative biopsies and as an intermediate biomarker in Phase II chemoprevention trials. The results also suggest that subvisual disturbances in nuclear structure precede the development of pre-neoplastic lesions. PMID:23922715

Gann, Peter H.; Deaton, Ryan; Amatya, Anup; Mohnani, Mahesh; Rueter, Erika Enk; Yang, Yirong; Ananthanarayanan, Viju

2013-01-01

229

Shake a tail feather: the evolution of the theropod tail into a stiff aerodynamic surface.  

PubMed

Theropod dinosaurs show striking morphological and functional tail variation; e.g., a long, robust, basal theropod tail used for counterbalance, or a short, modern avian tail used as an aerodynamic surface. We used a quantitative morphological and functional analysis to reconstruct intervertebral joint stiffness in the tail along the theropod lineage to extant birds. This provides new details of the tail's morphological transformation, and for the first time quantitatively evaluates its biomechanical consequences. We observe that both dorsoventral and lateral joint stiffness decreased along the non-avian theropod lineage (between nodes Theropoda and Paraves). Our results show how the tail structure of non-avian theropods was mechanically appropriate for holding itself up against gravity and maintaining passive balance. However, as dorsoventral and lateral joint stiffness decreased, the tail may have become more effective for dynamically maintaining balance. This supports our hypothesis of a reduction of dorsoventral and lateral joint stiffness in shorter tails. Along the avian theropod lineage (Avialae to crown group birds), dorsoventral and lateral joint stiffness increased overall, which appears to contradict our null expectation. We infer that this departure in joint stiffness is specific to the tail's aerodynamic role and the functional constraints imposed by it. Increased dorsoventral and lateral joint stiffness may have facilitated a gradually improved capacity to lift, depress, and swing the tail. The associated morphological changes should have resulted in a tail capable of producing larger muscular forces to utilise larger lift forces in flight. Improved joint mobility in neornithine birds potentially permitted an increase in the range of lift force vector orientations, which might have improved flight proficiency and manoeuvrability. The tail morphology of modern birds with tail fanning capabilities originated in early ornithuromorph birds. Hence, these capabilities should have been present in the early Cretaceous, with incipient tail-fanning capacity in the earliest pygostylian birds. PMID:23690987

Pittman, Michael; Gatesy, Stephen M; Upchurch, Paul; Goswami, Anjali; Hutchinson, John R

2013-01-01

230

Diagnosis of Amyloidosis and Differentiation from Chronic, Idiopathic Enterocolitis in Rhesus (Macaca mulatta) and Pig-Tailed (M. nemestrina) Macaques  

PubMed Central

Amyloidosis is a progressive and ultimately fatal disease in which amyloid, an insoluble fibrillar protein, is deposited inappropriately in multiple organs, eventually leading to organ dysfunction. Although this condition commonly affects macaques, there is currently no reliable method of early diagnosis. Changes in clinical pathology parameters have been associated with amyloidosis but occur in late stages of disease, are nonspecific, and resemble those seen in chronic, idiopathic enterocolitis. A review of animal records revealed that amyloidosis was almost always diagnosed postmortem, with prevalences of 15% and 25% in our rhesus and pig-tailed macaque colonies, respectively. As a noninvasive, high-throughput diagnostic approach to improve antemortem diagnosis of amyloidosis in macaques, we evaluated serum amyloid A (SAA), an acute-phase protein and the precursor to amyloid. Using necropsy records and ELISA analysis of banked serum, we found that SAA is significantly elevated in both rhesus and pig-tailed macaques with amyloid compared with those with chronic enterocolitis and healthy controls. At necropsy, 92% of rhesus and 83% of pig-tailed had amyloid deposition in either the intestines or liver. Minimally invasive biopsy techniques including endoscopy of the small intestine, mucosal biopsy of the colon, and ultrasound-guided trucut biopsy of the liver were used to differentiate macaques in our colonies with similar clinical presentations as either having amyloidosis or chronic, idiopathic enterocolitis. Our data suggest that SAA can serve as an effective noninvasive screening tool for amyloidosis and that minimally invasive biopsies can be used to confirm this diagnosis. PMID:23759529

Rice, Kelly A; Chen, Edward S; Pate, Kelly A Metcalf; Hutchinson, Eric K; Adams, Robert J

2013-01-01

231

Spontaneous Atopic Dermatitis-Like Symptoms in a/a ma ft/ma ft/J Flaky Tail Mice Appear Early after Birth  

PubMed Central

Loss-of-function mutations in human profilaggrin gene have been identified as the cause of ichthyosis vulgaris (IV), and as a major predisposition factor for atopic dermatitis (AD). Similarly, flaky tail (a/a ma ft/ma ft/J) mice were described as a model for IV, and shown to be predisposed to eczema. The aim of this study was to correlate the flaky tail mouse phenotype with human IV and AD, in order to dissect early molecular events leading to atopic dermatitis in mice and men, suffering from filaggrin deficiency. Thus, 5-days old flaky tail pups were analyzed histologically, expression of cytokines was measured in skin and signaling pathways were investigated by protein analysis. Human biopsies of IV and AD patients were analyzed histologically and by real time PCR assays. Our data show acanthosis and hyperproliferation in flaky tail epidermis, associated with increased IL1? and thymic stromal lymphopoietin (TSLP) expression, and Th2-polarization. Consequently, NF?B and Stat pathways were activated, and IL6 mRNA levels were increased. Further, quantitative analysis of late epidermal differentiation markers revealed increased Small proline-rich protein 2A (Sprr2a) synthesis. Th2-polarization and Sprr2a increase may result from high TSLP expression, as shown after analysis of 5-days old K14-TSLP tg mouse skin biopsies. Our findings in the flaky tail mouse correlate with data obtained from patient biopsies of AD, but not IV. We propose that proinflammatory cytokines are responsible for acanthosis in flaky tail epidermis, and together with the Th2-derived cytokines lead to morphological changes. Accordingly, the a/a ma ft/ma ft/J mouse model can be used as an appropriate model to study early AD onset associated with profilaggrin deficiency. PMID:23844115

Kypriotou, Magdalini; Boechat, Cloe; Huber, Marcel; Hohl, Daniel

2013-01-01

232

A low background Raman probe for optical biopsy of brain tissue  

NASA Astrophysics Data System (ADS)

Removal of intrinsic brain tumours is a delicate process, where a high degree of specificity is required to remove all of the tumour tissue without damaging healthy brain. The accuracy of this process can be greatly enhanced by intraoperative guidance. Optical biopsies using Raman spectroscopy are a minimally invasive and lower cost alternative to current guidance methods. A miniature Raman probe for performing optical biopsies of human brain tissue is presented. The probe allows sampling inside a conventional stereotactic brain biopsy system: a needle of length 200mm and inner diameter of 1.8mm. The probe achieves a very low fluorescent background whilst maintaining good collection of Raman signal by employing a miniature stand-off Raman design. To illustrate this, the probe is compared with a Raman probe that uses a pair of optical fibres for collection. The miniature stand-off Raman probe is shown to collect a comparable number of Raman scattered photons, but the fluorescence caused by silica fibres in a Raman needle probe is reduced by a factor of two for Raman shifts under 500 cm-1, and by 30% at 600-700 cm-1. In addition, this design contains only medically approved materials at the distal end. The probe's suitability for use on tissue is demonstrated by discriminating between different types of porcine brain tissue.

Stevens, Oliver A. C.; Hutchings, Joanne; Gray, William; Day, John C.

2014-03-01

233

[Complications of transrectal prostate biopsy. Determination of current status].  

PubMed

The procedure for prostate biopsy has undergone a dramatic change in the last 2 decades. The introduction of PSA into diagnostics for prostate carcinoma and simultaneous development of modern biopsy techniques have led to a marked increase in transrectal prostate biopsies. At the same time, serious complications have become less frequent. Grave complications after biopsy include septic complications (approximately 1%), rectal hemorrhages (approximately 0.1%), and ischurias (0.5%). Less severe complications such as occurrence of fever without septic signs account for 3.5%. One of the frequent complications that usually do not require treatment is gross hematuria, which is observed in nearly 50% of all patients. The same applies to hematospermia with a similar frequency.In the rare cases of the altogether serious complications after prostate biopsy, appropriate action is essential. All in all, prostate biopsy nowadays represents a safe diagnostic procedure with few complications and an extraordinarily high level of usefulness for everyday urological practice. PMID:14513224

Gottfried, H W; Volkmer, B

2003-08-01

234

Tamarind tree seed dispersal by ring-tailed lemurs.  

PubMed

In Madagascar, the gallery forests of the south are among the most endangered. Tamarind trees (Tamarindus indica) dominate these riverine forests and are a keystone food resource for ring-tailed lemurs (Lemur catta). At Berenty Reserve, the presence of tamarind trees is declining, and there is little recruitment of young trees. Because mature tamarinds inhibit growth under their crowns, seeds must be dispersed away from adult trees if tree recruitment is to occur. Ring-tailed lemurs are likely seed dispersers; however, because they spend much of their feeding, siesta, and sleeping time in tamarinds, they may defecate a majority of the tamarind seeds under tamarind trees. To determine whether they disperse tamarind seeds away from overhanging tamarind tree crowns, we observed two troops for 10 days each, noted the locations of feeding and defecation, and collected seeds from feces and fruit for germination. We also collected additional data on tamarind seedling recruitment under natural conditions, in which seedling germination was abundant after extensive rain, including under the canopy. However, seedling survival to 1 year was lower when growing under mature tamarind tree crowns than when growing away from an overhanging crown. Despite low fruit abundance averaging two fruits/m(3) in tamarind crowns, lemurs fed on tamarind fruit for 32% of their feeding samples. Daily path lengths averaged 1,266 m, and lemurs deposited seeds throughout their ranges. Fifty-eight percent of the 417 recorded lemur defecations were on the ground away from overhanging tamarind tree crowns. Tamarind seeds collected from both fruit and feces germinated. Because lemurs deposited viable seeds on the ground away from overhanging mature tamarind tree crowns, we conclude that ring-tailed lemurs provide tamarind tree seed dispersal services. PMID:21629992

Mertl-Millhollen, Anne S; Blumenfeld-Jones, Kathryn; Raharison, Sahoby Marin; Tsaramanana, Donald Raymond; Rasamimanana, Hantanirina

2011-10-01

235

Cryobiopsy: Should This Be Used in Place of Endobronchial Forceps Biopsies?  

PubMed Central

Forceps biopsies of airway lesions have variable yields. The yield increases when combining techniques in order to collect more material. With the use of cryotherapy probes (cryobiopsy) larger specimens can be obtained, resulting in an increase in the diagnostic yield. However, the utility and safety of cryobiopsy with all types of lesions, including flat mucosal lesions, is not established. Aims. Demonstrate the utility/safety of cryobiopsy versus forceps biopsy to sample exophytic and flat airway lesions. Settings and Design. Teaching hospital-based retrospective analysis. Methods. Retrospective analysis of patients undergoing cryobiopsies (singly or combined with forceps biopsies) from August 2008 through August 2010. Statistical Analysis. Wilcoxon signed-rank test. Results. The comparative analysis of 22 patients with cryobiopsy and forceps biopsy of the same lesion showed the mean volumes of material obtained with cryobiopsy were significantly larger (0.696?cm3 versus 0.0373?cm3, P = 0.0014). Of 31 cryobiopsies performed, one had minor bleeding. Cryopbiopsy allowed sampling of exophytic and flat lesions that were located centrally or distally. Cryobiopsies were shown to be safe, free of artifact, and provided a diagnostic yield of 96.77%. Conclusions. Cryobiopsy allows safe sampling of exophytic and flat airway lesions, with larger specimens, excellent tissue preservation and high diagnostic accuracy. PMID:24066296

Rubio, Edmundo R.; le, Susanti R.; Whatley, Ralph E.; Boyd, Michael B.

2013-01-01

236

Biopsy of Different Oral Soft Tissues Lesions by KTP and Diode Laser: Histological Evaluation  

PubMed Central

Introduction. Oral biopsy aims to obtain clear and safe diagnosis; it can be performed by scalpel or laser. The controversy in this latter application is the thermal alteration due to tissue heating. The aim of this study is the histological evaluation of margins of “in vivo” biopsies collected by diode and KTP lasers. Material and Methods. 17 oral benign lesions biopsies were made by diode 808?nm (SOL, DenMatItalia, Italy) and KTP 532?nm (SmartLite, DEKA, Italy). Samples were observed at OM LEICA DM 2000; margin alterations were evaluated through Leica Application Suite 3.4. Results. Epithelial and connective damages were assessed for each pathology with an average of 0.245?mm and a standard deviation of ±0.162?mm in mucoceles, 0.382?mm ± 0.149?mm in fibromas, 0.336?mm ± 0.106?mm in hyperkeratosis, 0.473?mm ± 0.105?mm in squamous hyperplasia, 0.182?mm in giant cell granuloma, and 0.149?mm in melanotic macula. Discussion. The histologic aspect of lesions influenced the response to laser, whereas the greater inflammation and cellularity were linked with the higher thermal signs. Many artifacts were also associated to histologic procedures. Conclusion. Both tested lasers permitted sure histologic diagnosis. However, it is suggested to enlarge biopsies of about 0.5?mm, to avoid thermal alterations, especially in inflammatory lesions like oral lichen planus.

Romeo, Umberto; Russo, Claudia; Lo Giudice, Rossella; Visca, Paolo; Migliau, Guido

2014-01-01

237

Satellite tagging and biopsy sampling of killer whales at subantarctic marion island: effectiveness, immediate reactions and long-term responses.  

PubMed

Remote tissue biopsy sampling and satellite tagging are becoming widely used in large marine vertebrate studies because they allow the collection of a diverse suite of otherwise difficult-to-obtain data which are critical in understanding the ecology of these species and to their conservation and management. Researchers must carefully consider their methods not only from an animal welfare perspective, but also to ensure the scientific rigour and validity of their results. We report methods for shore-based, remote biopsy sampling and satellite tagging of killer whales Orcinus orca at Subantarctic Marion Island. The performance of these methods is critically assessed using 1) the attachment duration of low-impact minimally percutaneous satellite tags; 2) the immediate behavioural reactions of animals to biopsy sampling and satellite tagging; 3) the effect of researcher experience on biopsy sampling and satellite tagging; and 4) the mid- (1 month) and long- (24 month) term behavioural consequences. To study mid- and long-term behavioural changes we used multievent capture-recapture models that accommodate imperfect detection and individual heterogeneity. We made 72 biopsy sampling attempts (resulting in 32 tissue samples) and 37 satellite tagging attempts (deploying 19 tags). Biopsy sampling success rates were low (43%), but tagging rates were high with improved tag designs (86%). The improved tags remained attached for 26±14 days (mean ± SD). Individuals most often showed no reaction when attempts missed (66%) and a slight reaction-defined as a slight flinch, slight shake, short acceleration, or immediate dive-when hit (54%). Severe immediate reactions were never observed. Hit or miss and age-sex class were important predictors of the reaction, but the method (tag or biopsy) was unimportant. Multievent trap-dependence modelling revealed considerable variation in individual sighting patterns; however, there were no significant mid- or long-term changes following biopsy sampling or tagging. PMID:25375329

Reisinger, Ryan R; Oosthuizen, W Chris; Péron, Guillaume; Cory Toussaint, Dawn; Andrews, Russel D; de Bruyn, P J Nico

2014-01-01

238

Satellite Tagging and Biopsy Sampling of Killer Whales at Subantarctic Marion Island: Effectiveness, Immediate Reactions and Long-Term Responses  

PubMed Central

Remote tissue biopsy sampling and satellite tagging are becoming widely used in large marine vertebrate studies because they allow the collection of a diverse suite of otherwise difficult-to-obtain data which are critical in understanding the ecology of these species and to their conservation and management. Researchers must carefully consider their methods not only from an animal welfare perspective, but also to ensure the scientific rigour and validity of their results. We report methods for shore-based, remote biopsy sampling and satellite tagging of killer whales Orcinus orca at Subantarctic Marion Island. The performance of these methods is critically assessed using 1) the attachment duration of low-impact minimally percutaneous satellite tags; 2) the immediate behavioural reactions of animals to biopsy sampling and satellite tagging; 3) the effect of researcher experience on biopsy sampling and satellite tagging; and 4) the mid- (1 month) and long- (24 month) term behavioural consequences. To study mid- and long-term behavioural changes we used multievent capture-recapture models that accommodate imperfect detection and individual heterogeneity. We made 72 biopsy sampling attempts (resulting in 32 tissue samples) and 37 satellite tagging attempts (deploying 19 tags). Biopsy sampling success rates were low (43%), but tagging rates were high with improved tag designs (86%). The improved tags remained attached for 26±14 days (mean ± SD). Individuals most often showed no reaction when attempts missed (66%) and a slight reaction–defined as a slight flinch, slight shake, short acceleration, or immediate dive–when hit (54%). Severe immediate reactions were never observed. Hit or miss and age-sex class were important predictors of the reaction, but the method (tag or biopsy) was unimportant. Multievent trap-dependence modelling revealed considerable variation in individual sighting patterns; however, there were no significant mid- or long-term changes following biopsy sampling or tagging. PMID:25375329

Reisinger, Ryan R.; Oosthuizen, W. Chris; Péron, Guillaume; Cory Toussaint, Dawn; Andrews, Russel D.; de Bruyn, P. J. Nico

2014-01-01

239

Engineering assessment of inactive uranium mill tailings  

SciTech Connect

The Grand Junction site has been reevaluated in order to revise the October 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Grand Junction, Colorado. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 1.9 million tons of tailings at the Grand Junction site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation are also factors. The eight alternative actions presented herein range from millsite and off-site decontamination with the addition of 3 m of stabilization cover material (Option I), to removal of the tailings to remote disposal sites and decontamination of the tailings site (Options II through VIII). Cost estimates for the eight options range from about $10,200,000 for stabilization in-place to about $39,500,000 for disposal in the DeBeque area, at a distance of about 35 mi, using transportation by rail. If transportation to DeBeque were by truck, the cost estimated to be about $41,900,000. Three principal alternatives for the reprocessing of the Grand Junction tailings were examined: (a) heap leaching; (b) treatment at an existing mill; and (c) reprocessing at a new conventional mill constructed for tailings reprocessing. The cost of the uranium recovered would be about $200/lb by heap leach and $150/lb by conventional plant processes. The spot market price for uranium was $25/lb early in 1981. Therefore, reprocessing the tailings for uranium recovery appears not to be economically attractive.

Not Available

1981-07-01

240

Variation in Salamander Tail Regeneration Is Associated with Genetic Factors That Determine Tail Morphology  

PubMed Central

Very little is known about the factors that cause variation in regenerative potential within and between species. Here, we used a genetic approach to identify heritable genetic factors that explain variation in tail regenerative outgrowth. A hybrid ambystomatid salamander (Ambystoma mexicanum x A. andersoni) was crossed to an A. mexicanum and 217 offspring were induced to undergo metamorphosis and attain terrestrial adult morphology using thyroid hormone. Following metamorphosis, each salamander’s tail tip was amputated and allowed to regenerate, and then amputated a second time and allowed to regenerate. Also, DNA was isolated from all individuals and genotypes were determined for 187 molecular markers distributed throughout the genome. The area of tissue that regenerated after the first and second amputations was highly positively correlated across males and females. Males presented wider tails and regenerated more tail tissue during both episodes of regeneration. Approximately 66–68% of the variation in regenerative outgrowth was explained by tail width, while tail length and genetic sex did not explain a significant amount of variation. A small effect QTL was identified as having a sex-independent effect on tail regeneration, but this QTL was only identified for the first episode of regeneration. Several molecular markers significantly affected regenerative outgrowth during both episodes of regeneration, but the effect sizes were small (<4%) and correlated with tail width. The results show that ambysex and minor effect QTL explain variation in adult tail morphology and importantly, tail width. In turn, tail width at the amputation plane largely determines the rate of regenerative outgrowth. Because amputations in this study were made at approximately the same position of the tail, our results resolve an outstanding question in regenerative biology: regenerative outgrowth positively co-varies as a function of tail width at the amputation site. PMID:23843997

Voss, Gareth J.; Kump, D. Kevin; Walker, John A.; Voss, S. Randal

2013-01-01

241

Variation in salamander tail regeneration is associated with genetic factors that determine tail morphology.  

PubMed

Very little is known about the factors that cause variation in regenerative potential within and between species. Here, we used a genetic approach to identify heritable genetic factors that explain variation in tail regenerative outgrowth. A hybrid ambystomatid salamander (Ambystoma mexicanum x A. andersoni) was crossed to an A. mexicanum and 217 offspring were induced to undergo metamorphosis and attain terrestrial adult morphology using thyroid hormone. Following metamorphosis, each salamander's tail tip was amputated and allowed to regenerate, and then amputated a second time and allowed to regenerate. Also, DNA was isolated from all individuals and genotypes were determined for 187 molecular markers distributed throughout the genome. The area of tissue that regenerated after the first and second amputations was highly positively correlated across males and females. Males presented wider tails and regenerated more tail tissue during both episodes of regeneration. Approximately 66-68% of the variation in regenerative outgrowth was explained by tail width, while tail length and genetic sex did not explain a significant amount of variation. A small effect QTL was identified as having a sex-independent effect on tail regeneration, but this QTL was only identified for the first episode of regeneration. Several molecular markers significantly affected regenerative outgrowth during both episodes of regeneration, but the effect sizes were small (<4%) and correlated with tail width. The results show that ambysex and minor effect QTL explain variation in adult tail morphology and importantly, tail width. In turn, tail width at the amputation plane largely determines the rate of regenerative outgrowth. Because amputations in this study were made at approximately the same position of the tail, our results resolve an outstanding question in regenerative biology: regenerative outgrowth positively co-varies as a function of tail width at the amputation site. PMID:23843997

Voss, Gareth J; Kump, D Kevin; Walker, John A; Voss, S Randal

2013-01-01

242

Constraining dark halos with tidal tails  

E-print Network

Massive and extended dark halos can inhibit the formation of long tidal tails in galaxy collisions. We examine this effect using an extensive survey of simulations with different dark halo potentials to constrain halo properties of interacting galaxies. These constraints are compared to other observational limits and theoretical predictions of halo structure. The dark halos predicted by $\\Omega=1$ cosmological models like CDM are too massive and extended to produce the long tidal tails seen in nearby galaxy collisions. There is also a conflict with the halo potentials inferred from satellite kinematics; such halos would likewise inhibit tail formation in galaxy collisions.

John Dubinski; Chris Mihos; Lars Hernquist

1997-12-08

243

Percutaneous Liver Biopsies Guided with Ultrasonography: A Case Series  

PubMed Central

Background Although liver biopsy is an easy procedure for hospitalized patients and outpatients, some complications may occur. Objectives To evaluate the efficiency, complications, safety and clinicopathological utility of ultrasonographic-guided percutaneous liver biopsy in diffuse liver disease. Patients and Methods In our retrospective study, we evaluated ultrasound-assisted needle biopsies that were performed in outpatients from October 2006 to July 2010. The liver biopsies were performed following one-night fasting using the tru-cut biopsy gun (18-20 gauge) after marking the best seen and hypovascular part of the liver, distant enough from the adjacent organs. Results A total of 1018 patients were referred to our radiology department. Most of the patients had hepatitis B (60.6%). The biopsy specimens were recorded and sent to our pathology department for histopathological examination. Conclusion According to the results of our series, percutaneous liver biopsy using the tru-cut biopsy gun guided by ultrasonography can be performed safely. We resolve that routine ultrasound of the puncture site is a quick, effective and safe procedure. The complication rate is very low. The US-assisted percutaneous liver biopsy should be used for all cases. PMID:24348609

Cakmakci, Emin; Caliskan, Kosti Can; Tabakci, Omer Naci; Tahtabasi, Mehmet; Karpat, Zeki

2013-01-01

244

Mercury's Dynamic Magnetic Tail (Invited)  

NASA Astrophysics Data System (ADS)

The Mariner 10 and MESSENGER flybys of Mercury have revealed a magnetosphere that is likely the most responsive to upstream interplanetary conditions of any in the solar system. The sources of the great dynamic variability observed during these brief flybys certainly include Mercury’s proximity to the Sun and the inverse proportionality between reconnection rate and solar wind Alfven Mach number. However, this planet’s lack of an ionosphere and its small physical dimensions also contribute. In particular, Mercury’s very brief Dungey cycle, ~ 2 min, which governs the time scale for internal plasma circulation, allows for very rapid transitions to new equilibrium states. Current observations and understanding of the structure and dynamics of Mercury’s magnetotail are summarized and discussed. Special emphasis will be placed upon such questions as: 1) How much access does the solar wind have to this small magnetosphere as a function of upstream conditions? 2) What roles do heavy planetary ions play? 3) Do Earth-like substorms take place at Mercury? 4) How does Mercury’s tail respond to extreme solar wind events such coronal mass ejections? Prospects for progress due to advances in the global magnetohydrodynamic and hybrid simulation modeling and the measurements to be taken by MESSENGER after it enters Mercury orbit on March 18, 2011 will be discussed.

Slavin, J. A.

2010-12-01

245

A Christmas "E-Tail"  

NSDL National Science Digital Library

As the weather outside turns frightful, retail businesses with "e-tail" (electronic retail) Websites are hoping that consumers will turn to their home computers for their holiday shopping. A Forrester Research report estimates that seven million shoppers will spend close to $4 billion in online shopping, three times more than last year. However, this equals less than one percent of total holiday spending, estimated at $184 billion this holiday season. Most online retailers have increased the capacity and speed of their Websites in order to best serve holiday shoppers, hoping that this year's online shopping experiences will lead consumers to do a greater amount of next year's holiday shopping by way of the World Wide Web. While consumers are willing to try e-commerce sites, as many as 40 percent of experienced Internet users have found the process of online shopping confusing and complicated. This week's In the News examines the trend of online shopping with the following seven resources including news articles, advice, and related Websites.

Missner, Emily D.

246

Tail Reconnection Triggering Substorm Onset  

NASA Astrophysics Data System (ADS)

We report on simultaneous magnetotail measurements by THEMIS at multiple distances, at the time of substorm onset, which occured on Feb 26, 2008. Evidence for reconnection including bipolar magnetic field, inflow towards the neutral sheet and counterstreaming electrons was observed at P1 and P2, suggesting that the reconnection site was at 20 Re. Evidence for current disruption, including dipolarization, turbulence and plasma heating were observed at P3 and P4 at ~11Re. Remote sensing of the current disruption region onset was not possible but particle distributions suggest that the plasma had started moving Earthward ahead of the dipolarization, i.e., point towards a source tailward of the P3, P4 satellites. Auroral brightening and poleward expansion was observed after reconnection onset and before dipolarization onset, suggesting that this event was triggered by reconnection around 20Re. Observations from a number of similar events show that a consistent picture of onset is starting to emerge from the first tail season. We discuss implications for substorm models and for auroral particle acceleration.

Angelopoulos, V.; McFadden, J.; Larson, D.; Carlson, C.; Mende, S.; Frey, H.; Phan, T.; Sibeck, D.; Glassmeier, K.; Auster, U.; Donovan, E.; Mann, I.; Rae, J.; Russell, C.; Runov, A.; Zhou, X.; Kepko, L.

2008-12-01

247

Automated quantitative muscle biopsy analysis system  

NASA Technical Reports Server (NTRS)

An automated system to aid the diagnosis of neuromuscular diseases by producing fiber size histograms utilizing histochemically stained muscle biopsy tissue. Televised images of the microscopic fibers are processed electronically by a multi-microprocessor computer, which isolates, measures, and classifies the fibers and displays the fiber size distribution. The architecture of the multi-microprocessor computer, which is iterated to any required degree of complexity, features a series of individual microprocessors P.sub.n each receiving data from a shared memory M.sub.n-1 and outputing processed data to a separate shared memory M.sub.n+1 under control of a program stored in dedicated memory M.sub.n.

Castleman, Kenneth R. (Inventor)

1980-01-01

248

Microfabricated instrument for tissue biopsy and analysis  

DOEpatents

A microfabricated biopsy/histology instrument which has several advantages over the conventional procedures, including minimal specimen handling, smooth cutting edges with atomic sharpness capable of slicing very thin specimens (approximately 2 .mu.m or greater), micro-liter volumes of chemicals for treating the specimens, low cost, disposable, fabrication process which renders sterile parts, and ease of use. The cutter is a "cheese-grater" style design comprising a block or substrate of silicon and which uses anisotropic etching of the silicon to form extremely sharp and precise cutting edges. As a specimen is cut, it passes through the silicon cutter and lies flat on a piece of glass which is bonded to the cutter. Microchannels are etched into the glass or silicon substrates for delivering small volumes of chemicals for treating the specimen. After treatment, the specimens can be examined through the glass substrate.

Krulevitch, Peter A. (Pleasanton, CA); Lee, Abraham P. (Walnut Creek, CA); Northrup, M. Allen (Berkeley, CA); Benett, William J. (Livermore, CA)

2001-01-01

249

Sentinel node biopsy: an in depth appraisal.  

PubMed

Sentinel node biopsy (SNB) in primary breast cancer has been taken-up widely to avoid the morbidity attributable to axillary node clearance (ANC). Currently many issues surrounding SNB are undecided. This review summarises why some form of axillary surgery is required and presents data on all aspects of SNB including methodology, clinical results and problems that may delay the introduction of SNB as best practice for all patients with primary breast cancer. There is no long or medium term data relating to the consequences of replacing ANC with SNB, but the mechanisms and probable magnitude of both beneficial and detrimental effects are estimated. A low level of false negative results are inherent to the technique but it is demonstrated that SNB is likely to have an only marginal (0.6%) effect on survival that would be undetectable by clinical trials. Patient sub-groups particularly likely to benefit from SNB are identified. PMID:12398999

Strickland, Andrew H; Beechey-Newman, Nicolas; Steer, Christopher B; Harper, Peter G

2002-10-01

250

Targeted cryotherapy using disposable biopsy punches.  

PubMed

Cryotherapy is a commonly used office procedure that causes destruction of tissue by cryonecrosis due to rapid freezing and thawing of cells. The limitation in treating plantar warts and deeper dermal lesions is that the freeze time should be longer to penetrate deeper, which results in collateral damage to normal skin surrounding the lesion. This results in unwanted side effects of prolonged pain, blistering and haemorrhage and increased healing time. The cone spray technique was used to reduce collateral damage, but deeper penetration is difficult to achieve. An innovative technique using disposable biopsy punches is described that ensures deeper freezing as compared to the plastic cone. The metal cutting edge of the punch enters deeper into the lesions as the liquid nitrogen is passed, sparing damage to surrounding skin. PMID:25136216

Prasad, Avitus John Raakesh

2014-04-01

251

Technical Note: Facilitating Laparoscopic Liver Biopsy by the Use of a Single-Handed Disposable Core Biopsy Needle  

PubMed Central

Despite the use of advanced radiological investigations, some liver lesions cannot be definitely diagnosed without a biopsy and histological examination. Laparoscopic Tru-Cut biopsy of the liver lesion is the preferred approach to achieve a good sample for histology. The mechanism of a Tru-Cut biopsy needle needs the use of both hands to load and fire the needle. This restricts the ability of the surgeon to direct the needle into the lesion utilising the laparoscopic ultrasound probe. We report a technique of laparoscopic liver biopsy using a disposable core biopsy instrument (BARD (R) disposable core biopsy needle) that can be used single-handedly. The needle can be positioned with laparoscopic graspers in order to reach posterior and superior lesions. This technique can easily be used in conjunction with laparoscopic ultrasound. PMID:23690654

Trochsler, M. I.; Ralph, Q.; Bridgewater, F.; Kanhere, H.; Maddern, Guy J.

2013-01-01

252

High prevalence of cutaneous human papillomavirus DNA on the top of skin tumors but not in "Stripped" biopsies from the same tumors.  

PubMed

Genomes of human papillomaviruses (HPV) are common in biopsies from non-melanoma skin cancers but are also found on healthy skin and it is possible that HPV positivity in tumor biopsies by PCR may merely reflect contamination of the lesion surface. To investigate this issue, 229 immunocompetent patients were tested for HPV DNA in swab samples collected on top of skin tumors and in biopsies of the same tumors, obtained after stripping with tape to remove superficial layers. HPV DNA was detected on top of 69% (159 of 229) of the lesions, and in 12% (28 of 229) of the stripped biopsies (p<0.001). The difference was seen for all four types of tumors studied. Seborrheic keratosis had 79% (34 of 43) HPV positivity on top of lesions versus 19% (eight of 43) in biopsies; actinic keratosis had 83% (38 of 46) HPV positivity on top versus 11% (five of 46) in biopsies; basal cell carcinoma had 63% (69 of 109) on top versus 8% (nine of 109) in biopsies and squamous cell carcinoma had 58% (18 of 31) on top versus 19% (six of 31) in biopsies. HPV DNA is common in superficial layers of lesions, but is not necessarily present throughout tumors. PMID:15245440

Forslund, Ola; Lindelöf, Bernt; Hradil, Eva; Nordin, Peter; Stenquist, Bo; Kirnbauer, Reinhard; Slupetzky, Katharina; Dillner, Joakim

2004-08-01

253

The Distant Sodium Tail of Mercury  

NASA Technical Reports Server (NTRS)

Models of the sodium atmosphere of Mercury predict the possible existence of a cornet-like sodium tail. Detection and mapping of the predicted sodium tail would provide quantitative data on the energy of the process that produces sodium atoms from the planetary surface. Previous efforts to detect the sodium tail by means of observations done during daylight hours have been only partially successful because scattered sunlight obscured the weak sodium emissions in the tail. However, at greatest eastern elongation around the March equinox in the northern hemisphere, Mercury can be seen as an evening star in astronomical twilight. At this time, the intensity of scattered sunlight is low enough that sodium emissions as low as 500 Rayleighs can be detected. Additional information is contained in the original extended abstract.

Potter, A. E.; Killen, R. M.; Morgan, T. H.

2001-01-01

254

Physical space and long-tail markets  

NASA Astrophysics Data System (ADS)

The Internet is known to have had a powerful impact on on-line retailer strategies in markets characterised by long-tail distribution of sales [C. Anderson, Long Tail: Why the Future of Business is Selling Less of More, Hyperion, New York, 2006]. Such retailers can exploit the long tail of the market, since they are effectively without physical limit on the number of choices on offer. Here we examine two extensions of this phenomenon. First, we introduce turnover into the long-tail distribution of sales. Although over any given period such as a week or a month, the distribution is right-skewed and often power law distributed, over time there is considerable turnover in the rankings of sales of individual products. Second, we establish some initial results on the implications for shelf-space and physical retailers in such markets.

Bentley, R. Alexander; Madsen, Mark E.; Ormerod, Paul

2009-03-01

255

OPERATING PLAN TAILINGS CELLS AND EVAPORATION PONDS  

E-print Network

OPERATING PLAN TAILINGS CELLS AND EVAPORATION PONDS PIÃ?ON RIDGE MILL Energy Fuels Resources ..........................................................................................4 3.0 EVAPORATION POND DESIGN....................................................................14 5.0 EVAPORATION PONDS OPERATING AND MONITORING PROCEDURES ....17 5.1 Standard Operating Procedures

256

Horizontal tail loads in maneuvering flight  

NASA Technical Reports Server (NTRS)

A method is given for determining the horizontal tail loads in maneuvering flight. The method is based upon the assignment of a load-factor variation with time and the determination of a minimum time to reach peak load factor. The tail load is separated into various components. Examination of these components indicated that one of the components was so small that it could be neglected for most conventional airplanes; therefore, the number of aerodynamic parameters needed in this computation of tail loads was reduced to a minimum. In order to illustrate the method, as well as to show the effect of the main variables, a number of examples are given. Some discussion is given regarding the determination of maximum tail loads, maximum pitching accelerations, and maximum pitching velocities obtainable.

Pearson, Henry A; Mcgowan, William A; Donegan, James J

1951-01-01

257

ATS Claus tail gas cleanup at Table Rock Tail Gas Plant. [Ammonium thiosulfate  

SciTech Connect

This paper describes the Table Rock Processing Plant which consists of four major parts: the treating plant, the dew point control plant, a sulfur plant, and the tail gas plant. The tail gas plant uses the ammonium thiosulfate process to convert about 4 tons per day of sulfur to 60 tons per day of ATS. The brief discussion is presented under headings: the tail gas process; chemistry (chemical reaction and equipment); plant performance. 7 refs.

White, S.P.

1981-01-01

258

Generalized processor sharing with light-tailed and heavy-tailed input  

Microsoft Academic Search

We consider a queue fed by a mixture of light-tailed and heavy-tailed traffic. The two traffic flows are served in accordance with the generalized processor sharing (GPS) discipline. GPS-based scheduling algorithms, such as weighted fair queueing, have emerged as an important mechanism for achieving service differentiation in integrated networks. We derive the asymptotic workload behavior of the light-tailed traffic flow

Sem C. Borst; Michel Mandjes; Miranda van Uitert

2003-01-01

259

TIDAL TAILS OF MINOR MERGERS. II. COMPARING STAR FORMATION IN THE TIDAL TAILS OF NGC 2782  

SciTech Connect

The peculiar spiral NGC 2782 is the result of a minor merger with a mass ratio {approx}4: 1 occurring {approx}200 Myr ago. This merger produced a molecular and H I-rich, optically bright eastern tail and an H I-rich, optically faint western tail. Non-detection of CO in the western tail by Braine et al. suggested that star formation had not yet begun. However, deep UBVR and H{alpha} narrowband images show evidence of recent star formation in the western tail, though it lacks massive star clusters and cluster complexes. Using Herschel PACS spectroscopy, we discover 158 {mu}m [C II] emission at the location of the three most luminous H{alpha} sources in the eastern tail, but not at the location of the even brighter H{alpha} source in the western tail. The western tail is found to have a normal star formation efficiency (SFE), but the eastern tail has a low SFE. The lack of CO and [C II] emission suggests that the western tail H II region may have a low carbon abundance and be undergoing its first star formation. The western tail is more efficient at forming stars, but lacks massive clusters. We propose that the low SFE in the eastern tail may be due to its formation as a splash region where gas heating is important even though it has sufficient molecular and neutral gas to make massive star clusters. The western tail, which has lower gas surface density and does not form high-mass star clusters, is a tidally formed region where gravitational compression likely enhances star formation.

Knierman, Karen A.; Scowen, Paul; Veach, Todd; Groppi, Christopher [School of Earth and Space Exploration, Arizona State University, 550 E. Tyler Mall, Room PSF-686 (P.O. Box 871404), Tempe, AZ 85287-1404 (United States); Mullan, Brendan; Charlton, Jane [Department of Astronomy and Astrophysics, Penn State University, 525 Davey Lab, University Park, PA (United States); Konstantopoulos, Iraklis [Australian Astronomical Observatory, P.O. Box 915, North Ryde NSW 1670 (Australia); Knezek, Patricia M., E-mail: karen.knierman@asu.edu, E-mail: paul.scowen@asu.edu, E-mail: tveach@asu.edu, E-mail: cgroppi@asu.edu, E-mail: mullan@astro.psu.edu, E-mail: iraklis@aao.gov.au, E-mail: pknezek@noao.edu [WIYN Consortium, Inc., 950 N. Cherry Avenue, Tucson, AZ 85719 (United States)

2013-09-10

260

Insect Collection  

NSDL National Science Digital Library

Learners use several types of insect sampling and collection equipment to make an insect collection. Learners can collect insects from their schoolyard or yard at home. Insect collections are a good way to estimate the abundance and number of species in an area. This can be a longterm project over a period of days or weeks.

Hill, Ryan; Vandersal, Nicole; Purcell, Alison

2011-01-01

261

The sodium tail of the Moon  

Microsoft Academic Search

During the few days centered about new Moon, the lunar surface is optically hidden from Earth-based observers. However, the Moon still offers an observable: an extended sodium tail. The lunar sodium tail is the escaping “hot” component of a coma-like exosphere of sodium generated by photon-stimulated desorption, solar wind sputtering and meteoroid impact. Neutral sodium atoms escaping lunar gravity experience

M. Matta; S. Smith; J. Baumgardner; J. Wilson; C. Martinis; M. Mendillo

2009-01-01

262

The sodium tail of the Moon  

NASA Astrophysics Data System (ADS)

During the few days centered about new Moon, the lunar surface is optically hidden from Earth-based observers. However, the Moon still offers an observable: an extended sodium tail. The lunar sodium tail is the escaping "hot" component of a coma-like exosphere of sodium generated by photon-stimulated desorption, solar wind sputtering and meteoroid impact. Neutral sodium atoms escaping lunar gravity experience solar radiation pressure that drives them into the anti-solar direction forming a comet-like tail. During new Moon time, the geometry of the Sun, Moon and Earth is such that the anti-sunward sodium flux is perturbed by the terrestrial gravitational field resulting in its focusing into a dense core that extends beyond the Earth. An all-sky camera situated at the El Leoncito Observatory (CASLEO) in Argentina has been successfully imaging this tail through a sodium filter at each lunation since April 2006. This paper reports on the results of the brightness of the lunar sodium tail spanning 31 lunations between April 2006 and September 2008. Brightness variability trends are compared with both sporadic and shower meteor activity, solar wind proton energy flux and solar near ultra violet (NUV) patterns for possible correlations. Results suggest minimal variability in the brightness of the observed lunar sodium tail, generally uncorrelated with any single source, yet consistent with a multi-year period of minimal solar activity and non-intense meteoric fluxes.

Matta, M.; Smith, S.; Baumgardner, J.; Wilson, J.; Martinis, C.; Mendillo, M.

2009-12-01

263

Optimization of Prostate Biopsy: the Role of Magnetic Resonance Imaging Targeted Biopsy in Detection, Localization and Risk Assessment  

PubMed Central

Purpose Optimization of prostate biopsy requires addressing the shortcomings of standard systematic transrectal ultrasound guided biopsy, including false-negative rates, incorrect risk stratification, detection of clinically insignificant disease and the need for repeat biopsy. Magnetic resonance imaging is an evolving noninvasive imaging modality that increases the accurate localization of prostate cancer at the time of biopsy, and thereby enhances clinical risk assessment and improves the ability to appropriately counsel patients regarding therapy. In this review we 1) summarize the various sequences that comprise a prostate multiparametric magnetic resonance imaging examination along with its performance characteristics in cancer detection, localization and reporting standards; 2) evaluate potential applications of magnetic resonance imaging targeting in prostate biopsy among men with no previous biopsy, a negative previous biopsy and those with low stage cancer; and 3) describe the techniques of magnetic resonance imaging targeted biopsy and comparative study outcomes. Materials and Methods A bibliographic search covering the period up to October 2013 was conducted using MEDLINE®/PubMed®. Articles were reviewed and categorized based on which of the 3 objectives of this review was addressed. Data were extracted, analyzed and summarized. Results Multiparametric magnetic resonance imaging consists of anatomical T2-weighted imaging coupled with at least 2 functional imaging techniques. It has demonstrated improved prostate cancer detection sensitivity up to 80% in the peripheral zone and 81% in the transition zone. A prostate cancer magnetic resonance imaging suspicion score has been developed, and is depicted using the Likert or PI-RADS (Prostate Imaging Reporting and Data System) scale for better standardization of magnetic resonance imaging interpretation and reporting. Among men with no previous biopsy, magnetic resonance imaging increases the frequency of significant cancer detection to 50% in low risk and 71% in high risk patients. In low risk men the negative predictive value of a combination of negative magnetic resonance imaging with prostate volume parameters is nearly 98%, suggesting a potential role in avoiding biopsy and reducing over detection/overtreatment. Among men with a previous negative biopsy 72% to 87% of cancers detected by magnetic resonance imaging guidance are clinically significant. Among men with a known low risk cancer, repeat biopsy using magnetic resonance targeting demonstrates a high likelihood of confirming low risk disease in low suspicion score lesions and of upgrading in high suspicion score lesions. Techniques of magnetic resonance imaging targeted biopsy include visual estimation transrectal ultrasound guided biopsy; software co-registered magnetic resonance imaging-ultrasound, transrectal ultrasound guided biopsy; and in-bore magnetic resonance imaging guided biopsy. Although the improvement in accuracy and efficiency of visual estimation biopsy compared to systematic appears limited, co-registered magnetic resonance imaging-ultrasound biopsy as well as in-bore magnetic resonance imaging guided biopsy appear to increase cancer detection rates in conjunction with increasing suspicion score. Conclusions Use of magnetic resonance imaging for targeting prostate biopsies has the potential to reduce the sampling error associated with conventional biopsy by providing better disease localization and sampling. More accurate risk stratification through improved cancer sampling may impact therapeutic decision making. Optimal clinical application of magnetic resonance imaging targeted biopsy remains under investigation. PMID:24769030

Bjurlin, Marc A.; Meng, Xiaosong; Le Nobin, Julien; Wysock, James S.; Lepor, Herbert; Rosenkrantz, Andrew B.; Taneja, Samir S.

2014-01-01

264

The red-tailed hawk, Buteo jamaicensis, a native definitive host of Frenkelia microti (Apicomplexa) in North America.  

PubMed

Oral inoculation of prairie voles, Microtus ochrogaster, with coccidian sporocysts isolated from the feces of a red-tailed hawk, Buteo jamaicensis, in Kansas, USA, resulted in formation of Frenkelia microti (Apicomplexa: Sarcocystidae) tissue cysts in the brains of the voles. Five additional isolates of morphologically similar sporocysts collected from red-tailed hawks or other Buteo spp. in Kansas failed to result in detectable infections in rodents. These results are the first to verify that red-tailed hawks are natural definitive host in North America for F. microti. PMID:1548806

Upton, S J; McKown, R D

1992-01-01

265

Contaminants in molting long-tailed ducks and nesting common eiders in the Beaufort Sea  

Microsoft Academic Search

In 2000, we collected blood from long-tailed ducks (Clangula hyemalis) and blood and eggs from common eiders (Somateria mollissima) at near-shore islands in the vicinity of Prudhoe Bay, Alaska, and at a reference area east of Prudhoe Bay. Blood was analyzed for trace elements and egg contents were analyzed for trace elements, organochlorine pesticides, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons.

J. c. Franson; T. e. Hollmen; P. l. Flint; J. b. Grand; R. b. Lanctot

2004-01-01

266

A PLAGUE EPIZOOTIC IN THE WHITE-TAILED PRAIRIE DOGS (CYNOMYS LEUCURUS) OF MEETEETSE, WYOMING  

Microsoft Academic Search

Surveillance for sylvatic plague (Yersinia pestis) was conducted near Meeteetse, Wyoming (USA) from 24 May to 14 june 1985. Ten species of fleas were collected from white- tailed prairie dogs (Cynomys leucurus), and from their burrows and associated rodents. Five of these flea species and two adult prairie dogs were positive for plague. The progression of this plague epizootic appeared

Sonya R. Ubico; Kathleen A. Fagerstone; Robert G. McLean

267

Newly Recognized Herpesvirus Causing Malignant Catarrhal Fever in White-Tailed Deer (Odocoileus virginianus)  

Microsoft Academic Search

Malignant catarrhal fever (MCF) was diagnosed by clinical signs and lesions in five out of six white-tailed deer (Odocoileus virginianus) in a North American zoo. The clinical signs and histopathological lesions in these deer were typical of MCF. Antibody to an epitope conserved among the MCF viruses was detected in the sera collected from the deer. PCR failed to amplify

HONG LI; NEIL DYER; JANICE KELLER; TIMOTHY B. CRAWFORD

268

Volatile Compounds from the Forehead Region of Male White-Tailed Deer ( Odocoileus virginianus )  

Microsoft Academic Search

Secretions produced by sebaceous and apocrine glands of cervids may be important in identifying individuals, establishing dominance, and signaling sexual readiness. The secretions from these glands are transferred to the hair for both lubrication and scent communication via forehead rubbing. We collected hair samples from the forehead and back of 10 male white-tailed deer (Odocoileus virginianus) of various ages and

J. W. Gassett; D. P. Wiesler; A. G. Baker; D. A. Osborn; K. V. Miller; R. L. Marchinton; M. Novotny

1997-01-01

269

Detection of hepatitis B virus covalently closed circular DNA in paraffin-embedded and cryo-preserved liver biopsies of chronic hepatitis B patients  

Microsoft Academic Search

Background Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) may become an important predictor for treatment outcome or long-term follow-up. Aim To detect cccDNA in formalin-fixed, paraffin embedded (FFPE) and to compare with cryo-preserved liver tissue. Methods Biopsies of 56 chronic hepatitis B patients were collected. Cryo-preserved and FFPE liver biopsies were available from 37 out of 56 patients.

R. Bart Takkenberg; Hans L. Zaaijer; Sandra Menting; Christine J. Weegink; Valeska Terpstra; Marion Cornelissen; Marcel G. W. Dijkgraaf; Peter L. M. Jansen; Hendrik W. Reesink; Marcel G. H. M. Beld

2010-01-01

270

Diagnosis of infantile neuroaxonal dystrophy by conjunctival biopsy  

Microsoft Academic Search

Conjunctival biopsy and ultrastructural examination of conjunctival nerves, showing the presence of spheroids within axons, led to the confirmation of the diagnosis of infantile neuroaxonal dystrophy in two children with progressive mental deterioration. Conjunctival biopsy, which is simple to perform, even in young children, and does not require general anaesthesia or admission to hospital, is presented as a reliable and

M L Arsénio-Nunes; F Goutières

1978-01-01

271

Molecular Signatures in Biopsy Specimens of Lung Cancer  

Microsoft Academic Search

Gene expression profiles of resected tumors may predict treatment response and outcome. We hypothesized that profiles derived from lung tumor biopsies would discriminate tumor-specific gene signa- tures and provide predictive information about outcome. Lung car- cinoma specimens were obtained from 23 patients undergoing computed tomography-guided transthoracic biopsy or endobron- chial brushing for undiagnosed nodules. Excess tissue was processed for gene

Alain C. Borczuk; Lori Shah; Gregory D. N. Pearson; Kristin L. Walter; Liqun Wang; John H. M. Austin; Richard A. Friedman; Charles A. Powell

2004-01-01

272

My approach to the interpretation of endometrial biopsies and curettings.  

PubMed

A major proportion of the workload in many histopathology laboratories is accounted for by endometrial biopsies, either curettage specimens or outpatient biopsy specimens. The increasing use of pipelle and other methods of biopsy not necessitating general anaesthesia has resulted in greater numbers of specimens with scant tissue, resulting in problems in assessing adequacy and in interpreting artefactual changes, some of which appear more common with outpatient biopsies. In this review, the criteria for adequacy and common artefacts in endometrial biopsies, as well as the interpretation of endometrial biopsies in general, are discussed, concentrating on areas that cause problems for pathologists. An adequate clinical history, including knowledge of the age, menstrual history and menopausal status, and information on the use of exogenous hormones and tamoxifen, is necessary for the pathologist to critically evaluate endometrial biopsies. Topics such as endometritis, endometrial polyps, changes that are induced by hormones and tamoxifen within the endometrium, endometrial metaplasias and hyperplasias, atypical polypoid adenomyoma, adenofibroma, adenosarcoma, histological types of endometrial carcinoma and grading of endometrial carcinomas are discussed with regard to endometrial biopsy specimens rather than hysterectomy specimens. The value of ancillary techniques, especially immunohistochemistry, is discussed where appropriate. PMID:16873562

McCluggage, W G

2006-08-01

273

My approach to the interpretation of endometrial biopsies and curettings  

PubMed Central

A major proportion of the workload in many histopathology laboratories is accounted for by endometrial biopsies, either curettage specimens or outpatient biopsy specimens. The increasing use of pipelle and other methods of biopsy not necessitating general anaesthesia has resulted in greater numbers of specimens with scant tissue, resulting in problems in assessing adequacy and in interpreting artefactual changes, some of which appear more common with outpatient biopsies. In this review, the criteria for adequacy and common artefacts in endometrial biopsies, as well as the interpretation of endometrial biopsies in general, are discussed, concentrating on areas that cause problems for pathologists. An adequate clinical history, including knowledge of the age, menstrual history and menopausal status, and information on the use of exogenous hormones and tamoxifen, is necessary for the pathologist to critically evaluate endometrial biopsies. Topics such as endometritis, endometrial polyps, changes that are induced by hormones and tamoxifen within the endometrium, endometrial metaplasias and hyperplasias, atypical polypoid adenomyoma, adenofibroma, adenosarcoma, histological types of endometrial carcinoma and grading of endometrial carcinomas are discussed with regard to endometrial biopsy specimens rather than hysterectomy specimens. The value of ancillary techniques, especially immunohistochemistry, is discussed where appropriate. PMID:16873562

McCluggage, W G

2006-01-01

274

Histologic diagnostic rate of cardiac sarcoidosis: Evaluation of endomyocardial biopsies  

Microsoft Academic Search

Background An early diagnosis of cardiac sarcoidosis is important, particularly when considering the need for administering corticosteroid therapy. However, no reports are available on the success rate of diagnosis on the basis of biopsy findings in patients with cardiac sarcoidosis. This study investigated the diagnostic success rate of histologic evaluation of endomyocardial biopsy specimens in patients with this disease. Methods

Akihisa Uemura; Shin-ichiro Morimoto; Shinya Hiramitsu; Yasuchika Kato; Teruo Ito; Hitoshi Hishida

1999-01-01

275

Liver biopsy in sheep M Hidiroglou M Ivan  

E-print Network

Short note Liver biopsy in sheep M Hidiroglou M Ivan Centre for Food and Animal Research) Summary ― Liver biopsies were performed in the same group of 16 sheep on 8 consecutive wk using 300 mg of fresh liver sample was removed from each sheep to be anal- yzed for copper or vitamin E

Paris-Sud XI, Université de

276

Advanced Breast Biopsy Instrumentation: Not Ready for Prime Time  

Microsoft Academic Search

It was not so long ago that when lesions were seen by mammogram, but not palpated, they were removed by “guestimate”. In 1985, Kopans first published the use of hookwire needle localization for breast biopsy; in 1987, stereotactic localization and fine-needle aspiration followed; and then, in 1990, came stereotactic core biopsy. Clearly, the trend was to move away from more

V. Suzanne Klimberg

1999-01-01

277

Transvaginal ultrasound, uterine biopsy and hysteroscopy for postmenopausal bleeding  

Microsoft Academic Search

Objectives: To determine the importance of endometrial biopsy and transvaginal ultrasound in patients with postmenopausal bleeding. Methods: Eighty patients with postmenopausal bleeding were submitted to transvaginal ultrasound followed by endometrial biopsy. Hysteroscopy and dilatation and curettage were carried out to confirm normality of the uterine cavity. Results: The endometrial echo could be visualized in all patients with postmenopausal bleeding. The

M. G. Giusa-Chiferi; W. J. Gonçalves; E. G. Baracat; L. Cavalcanti de Albuquerque Neto; C. C. R. Bortoletto; G. Rodrigues de Lima

1996-01-01

278

Reinforced terraced fields method for fine tailings disposal  

Microsoft Academic Search

New mining technologies can exploit low-grade ores but they produce high volumes of waste, such as tailings. Further, current mineral processing techniques produce more and more fine tailings. How to dispose of these tailings is a key issue in the sustainable operation of a mine. A traditional method is to construct a settling or tailings pond for storage. Such a

Zuoan Wei; Guangzhi Yin; Guangzhi Li; J. G. Wang; Ling Wan; Louyan Shen

2009-01-01

279

Volume III, Chapter 13 Columbian White-tailed Deer  

E-print Network

-tailed Deer (Odocoileus virginianus leucurus) ........................... 13-1 13.1 Introduction virginianus leucurus) 13.1 Introduction The Columbian white-tailed deer (Odocoileus virginianus leucurus............................................................................. 13-20 #12;COLUMBIAN WHITE-TAILED DEER III, 13-1 May 2004 13.0 Columbian White-tailed Deer (Odocoileus

280

A review of morphological characteristics relating to the production and reproduction of fat-tailed sheep breeds  

Microsoft Academic Search

The purpose of this study is to survey the literature pertinent to some morphological traits which are related with the production\\u000a and reproduction of fat-tailed sheep breeds. The fat-tailed breeds were identified according to Food and Agriculture Organization\\u000a databases. Articles referring to all these sheep breeds were evaluated. The morphology of udders and their measurable variables\\u000a were collected and described.

Aris F. Pourlis

2011-01-01

281

SEROLOGICAL PREVALENCE AND ISOLATION OF BABESIA ODOCOILE! AMONG WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) IN TEXAS AND OKLAHOMA  

Microsoft Academic Search

Serum samples collected from 581 white-tailed deer (Odocoileus virginianus) from Texas and from 124 white-tailed deer from Oklahoma were tested by the indirect fluorescent antibody technique against Babesia odocoilei. Prevalence of seropositive reactors varied from site to site in both states. Prevalence rates were statistically ranked as high, intermediate or low. Deer <12-mo-old had a significantly lower prevalence than all

K. A. Waldrup; A. A. Kocan; T. Qureshi; D. S. Davis; D. Baggett; G. G. Wagner

282

Isolation of Ehrlichia chaffeensis from Wild White-Tailed Deer (Odocoileus virginianus) Confirms Their Role as Natural Reservoir Hosts  

Microsoft Academic Search

Field and experimental studies have implicated white-tailed deer (Odocoileus virginianus) as probable reservoir hosts for Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis, but natural infection in deer has not been confirmed through isolation of E. chaffeensis. Thirty-five white-tailed deer collected from three Amblyomma americanum-infested populations in Georgia were examined for evidence of E. chaffeensis infection by serologic, molecular,

J. MITCHELL LOCKHART; WILLIAM R. DAVIDSON; DAVID E. STALLKNECHT; JACQUELINE E. DAWSON; ELIZABETH W. HOWERTH

1997-01-01

283

Aspiration biopsy of testis: another method for histologic examination  

SciTech Connect

The most important method for evaluating the pathogenesis of male infertility is open testicular biopsy. Herein the authors describe a method of aspiration biopsy of testis for histologic examination. Sexually mature dogs and rats treated with chemotherapeutic agents and ionizing radiation were followed with periodic testicular aspiration biopsy during and after treatment. The histologic findings from the aspiration biopsy compare with the results of routine histologic examination in assessing spermatogenetic activity and delineating pathologic changes. The puncture in the experimental animals was performed under general anesthesia. In human patients testicular biopsy could be done under local anesthesia in an outpatient clinic. The procedure would be less painful, minimally invasive, and more cost-effective.

Nseyo, U.O.; Englander, L.S.; Huben, R.P.; Pontes, J.E.

1984-08-01

284

A portable, low coherence interferometry based instrument for fine needle aspiration biopsy guidance  

NASA Astrophysics Data System (ADS)

A portable, low coherence interferometry (LCI) based instrument for fine-needle aspiration biopsy guidance is presented. The instrument consists of a fiber-based low coherence interferometer, a data acquisition, processing and display unit, and a probe. The probe, consisting of a 250?m diameter single-mode optical fiber inserted within the bore of a fine needle, is used to illuminate tissue and collect light from tissue at the tip of the needle. Light returning out of the probe is detected by the LCI system, which is capable of measuring depth-resolved information (reflectivity, spectra, birefringence) with a spatial resolution of 10?m over a depth range of approximately 1.4mm. The LCI based instrument can be used to guide the fine needle during biopsy procedures to potentially diagnose neoplasms, infections, inflammations, or infiltrations. The design and performance of the instrument, as well as preliminary measurements on excised breast tissue specimens, are presented in detail.

Iftimia, Nicusor V.; Bouma, Brett E.; Pitman, Martha B.; Goldberg, Brian; Bressner, Jason; Tearney, Guillermo J.

2005-06-01

285

Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus  

PubMed Central

Background The significance of amyloid precursor protein (APP) and neuroinflammation in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown. Objective To investigate the role of soluble APP (sAPP) and amyloid beta (A?) isoforms, proinflammatory cytokines, and biomarkers of neuronal damage in the cerebrospinal fluid (CSF) in relation to brain biopsy A? and hyperphosphorylated tau (HP?) findings. Methods The study population comprised 102 patients with possible NPH with cortical brain biopsies, ventricular and lumbar CSF samples, and DNA available. The final clinical diagnoses were: 53 iNPH (91% shunt-responders), 26 AD (10 mixed iNPH+AD), and 23 others. Biopsy samples were immunostained against A? and HP?. CSF levels of AD-related biomarkers (A?42, p-tau, total tau), non-AD-related A? isoforms (A?38, A?40), sAPP isoforms (sAPP?, sAPP?), proinflammatory cytokines (several interleukins (IL), interferon-gamma, monocyte chemoattractant protein-1, tumor necrosis factor-alpha) and biomarkers of neuronal damage (neurofilament light and myelin basic protein) were measured. All patients were genotyped for APOE. Results Lumbar CSF levels of sAPP? were lower (p<0.05) in patients with shunt-responsive iNPH compared to non-iNPH patients. sAPP? showed a similar trend (p?=?0.06). CSF sAPP isoform levels showed no association to A? or HP? in the brain biopsy. Quantified A? load in the brain biopsy showed a negative correlation with CSF levels of A?42 in ventricular (r?=??0.295, p?=?0.003) and lumbar (r?=??0.356, p?=?0.01) samples, while the levels of A?38 and A?40 showed no correlation. CSF levels of proinflammatory cytokines and biomarkers of neuronal damage did not associate to the brain biopsy findings, diagnosis, or shunt response. Higher lumbar/ventricular CSF IL-8 ratios (p<0.001) were seen in lumbar samples collected after ventriculostomy compared to the samples collected before the procedure. Conclusions The role of sAPP isoforms in iNPH seems to be independent from the amyloid cascade. No neuroinflammatory background was observed in iNPH or AD. PMID:24638077

Pyykko, Okko T.; Lumela, Miikka; Rummukainen, Jaana; Nerg, Ossi; Seppala, Toni T.; Herukka, Sanna-Kaisa; Koivisto, Anne M.; Alafuzoff, Irina; Puli, Lakshman; Savolainen, Sakari; Soininen, Hilkka; Jaaskelainen, Juha E.; Hiltunen, Mikko; Zetterberg, Henrik; Leinonen, Ville

2014-01-01

286

Augmented Reality Guidance for Needle Biopsies: A Randomized, Controlled Trial in Phantoms  

E-print Network

Augmented Reality Guidance for Needle Biopsies: A Randomized, Controlled Trial in Phantoms Michael-guided needle biopsy to biopsies performed using a 3D Augmented Reality (AR) guidance system. Fifty core biopsies of breast phantoms were conducted by a board-certified radiologist, with each set of five biopsies

287

Frame-based stereotactic biopsy remains an important diagnostic tool with distinct advantages over frameless stereotactic biopsy  

Microsoft Academic Search

Object: As the availability of image-guided surgical navigation systems has increased, the application of frame-based biopsy has declined at our institution, despite equivalent accuracy and safety. There are several cost issues separating the use of surgical navigation systems and stereotactic frames for simple biopsy which may have implications in this era of health care cost control. We retrospectively reviewed the

Justin S. Smith; Alfredo Quiñones-Hinojosa; Nicholas M. Barbaro; Michael W. McDermott

2005-01-01

288

Microfabricated instrument for tissue biopsy and analysis  

DOEpatents

A microfabricated biopsy/histology instrument which has several advantages over the conventional procedures, including minimal specimen handling, smooth cutting edges with atomic sharpness capable of slicing very thin specimens (approximately 2 .mu.m or greater), micro-liter volumes of chemicals for treating the specimens, low cost, disposable, fabrication process which renders sterile parts, and ease of use. The cutter is a "cheese-grater" style design comprising a block or substrate of silicon and which uses anisotropic etching of the silicon to form extremely sharp and precise cutting edges. As a specimen is cut, it passes through the silicon cutter and lies flat on a piece of glass which is bonded to the cutter. Microchannels are etched into the glass or silicon substrates for delivering small volumes of chemicals for treating the specimen. After treatment, the specimens can be examined through the glass substrate. For automation purposes, microvalves and micropumps may be incorporated. Also, specimens in parallel may be cut and treated with identical or varied chemicals. The instrument is disposable due to its low cost and thus could replace current expensive microtome and histology equipment.

Krulevitch, Peter A. (Pleasanton, CA); Lee, Abraham P. (Walnut Creek, CA); Northrup, M. Allen (Berkeley, CA); Benett, William J. (Livermore, CA)

1999-01-01

289

Sentinel node biopsy in early vulvar cancer  

PubMed Central

Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This study evaluates the feasibility of the surgical identification of sentinel groin nodes using lymphoscintigraphy and a gamma-detecting probe in patients with early vulvar cancer. Technetium-99m-labelled colloid human albumin was administered perilesionally in 37 patients with invasive epidermoid vulvar cancer (T1–T2) and lymphoscintigraphy performed the day before surgery. An intraoperative gamma-detecting probe was used to identify sentinel nodes during surgery. A complete inguinofemoral node dissection was then performed. Sentinel nodes were submitted separately to pathologic evaluation. A total of 55 groins were dissected in 37 patients. Localization of the SN was successful in all cases. Eight cases had positive nodes: in all the sentinel node as positive; the sentinel node was the only positive node in five cases. Twenty-nine patients showed negative sentinel nodes: all of them were negative for lymph node metastases. Lymphoscintigraphy and sentinel-node biopsy under gamma-detecting probe guidance proved to be an easy and reliable method for the detection of sentinel node in early vulvar cancer. This technique may represent a true advance in the direction of less aggressive treatments in patients with vulvar cancer. © 2000 Cancer Research Campaign PMID:10646880

Cicco, C De; Sideri, M; Bartolomei, M; Grana, C; Cremonesi, M; Fiorenza, M; Maggioni, A; Bocciolone, L; Mangioni, C; Colombo, N; Paganelli, G

2000-01-01

290

Hybrid tracers for sentinel node biopsy.  

PubMed

Conventional sentinel node (SN) mapping is performed by injection of a radiocolloid followed by lymphoscintigraphy to identify the number and location of the primary tumor draining lymph node(s), the so-called SN(s). Over the last decade research has focused on the introduction of new imaging agents that can further aid (surgical) SN identification. Different tracers for SN mapping, with varying sizes and isotopes have been reported, most of which have proven their value in a clinical setting. A major challenge lies in transferring this diagnostic information obtained at the nuclear medicine department to the operating theatre thereby providing the surgeon with (image) guidance. Conventionally, an intraoperative injection of vital blue dye or a fluorescence dye is given to allow intraoperative optical SN identification. However, for some indications, the radiotracer-based approach remains crucial. More recently, hybrid tracers, that contain both a radioactive and fluorescent label, were introduced to allow for direct integration of pre- and intraoperative guidance technologies. Their potential is especially high when they are used in combination with new surgical imaging modalities and navigation tools. Next to a description of the known tracers for SN mapping, this review discusses the application of hybrid tracers during SN biopsy and how the introduction of these new techniques can further aid in translation of nuclear medicine information into the operating theatre. PMID:24835293

Van Den Berg, N S; Buckle, T; Kleinjan, G I; Klop, W M; Horenblas, S; Van Der Poel, H G; Valdés-Olmos, R A; Van Leeuwen, F I

2014-06-01

291

Classification, imaging, biopsy and staging of osteosarcoma  

PubMed Central

Osteosarcoma is the most common primary osseous malignancy excluding malignant neoplasms of marrow origin (myeloma, lymphoma and leukemia) and accounts for approximately 20% of bone cancers. It predominantly affects patients younger than 20 years and mainly occurs in the long bones of the extremities, the most common being the metaphyseal area around the knee. These are classified as primary (central or surface) and secondary osteosarcomas arising in preexisting conditions. The conventional plain radiograph is the best for probable diagnosis as it describes features like sun burst appearance, Codman's triangle, new bone formation in soft tissues along with permeative pattern of destruction of the bone and other characteristics for specific subtypes of osteosarcomas. X-ray chest can detect metastasis in the lungs, but computerized tomography (CT) scan of the thorax is more helpful. Magnetic resonance imaging (MRI) of the lesion delineates its extent into the soft tissues, the medullary canal, the joint, skip lesions and the proximity of the tumor to the neurovascular structures. Tc99 bone scan detects the osseous metastases. Positron Emission Tomography (PET) is used for metastatic workup and/or local recurrence after resection. The role of biochemical markers like alkaline phosphatase and lactate dehydrogenase is pertinent for prognosis and treatment response. The biopsy confirms the diagnosis and reveals the grade of the tumor. Enneking system for staging malignant musculoskeletal tumors and American Joint Committee on Cancer (AJCC) staging systems are most commonly used for extremity sarcomas. PMID:24932027

Kundu, Zile Singh

2014-01-01

292

Collecting apparatus  

DOEpatents

An improved collecting apparatus for small aquatic or airborne organisms such as plankton, larval fish, insects, etc. The improvement constitutes an apertured removal container within which is retained a collecting bag, and which is secured at the apex of a conical collecting net. Such collectors are towed behind a vessel or vehicle with the open end of the conical net facing forward for trapping the aquatic or airborne organisms within the collecting bag, while allowing the water or air to pass through the apertures in the container. The container is readily removable from the collecting net whereby the collecting bag can be quickly removed and replaced for further sample collection. The collecting bag is provided with means for preventing the bag from being pulled into the container by the water or air flowing therethrough.

Duncan, Charles P. (Walnut Creek, CA)

1983-01-01

293

Ectoparasites of Black-tailed Prairie Dogs (Cynomys ludovicianus) from South Dakota  

Microsoft Academic Search

During the summers of 1982 and 1983, black-tailed prairie dogs (Cynomys lu- dovicianus) were examined for parasites. Those collected and their respective prevalence in- cluded Linognathoides cynomyis (46.3%), Opisocrostis hirsutus (53.7%), Opisocrostis tu- berculatus cynomuris (2.4%), Androlaelaps fah- renholzi (12.2%), Ixodes scuiptus (2.4%) and Dermacentor andersoni (4.9%). The collection data indicated that L. cynomyis, 0. hirsutus and A. fahrenholzi were

Glenn E. Kietzmann

294

An improved technique for tail-cuff blood pressure measurements with dark-tailed mice  

Microsoft Academic Search

Study of the genetics of hypertension has been facilitated greatly by the use of mice with modified genes that affect blood pressure. A current successful method for measuring blood pressure in mice relies on detection of light passing through the tail to determine the pressure in a tail-cuff necessary to stop pulsed flow. Success in obtaining reliable blood pressure measurements

J R Hagaman; S John; L Xu; O Smithies; N Maeda

2005-01-01

295

ATS Claus tail gas cleanup at Table Rock Tail Gas Plant. [Ammonium thiosulfate  

Microsoft Academic Search

This paper describes the Table Rock Processing Plant which consists of four major parts: the treating plant, the dew point control plant, a sulfur plant, and the tail gas plant. The tail gas plant uses the ammonium thiosulfate process to convert about 4 tons per day of sulfur to 60 tons per day of ATS. The brief discussion is presented

1981-01-01

296

Tidal Tails of Minor Mergers: Star Formation Efficiency in the Western Tail of NGC 2782  

E-print Network

While major mergers and their tidal debris are well studied, they are less common than minor mergers (mass ratios ratio of ~4:1 occurring ~200 Myr ago. This merger produced a molecular and H I-rich, optically bright eastern tail and an H I-rich, optically faint western tail. Non-detection of CO in the western tail by Braine et al. suggested that star formation had not yet begun to occur in that tidal tail. However, deep H{\\alpha} narrowband images show evidence of recent star formation in the western tail. Across the entire western tail, we find the global star formation rate per unit area ({\\Sigma}SFR) to be several orders of magnitude less than expected from the total gas density. Together with extended FUV+NUV emission from Galaxy Evolution Explorer along the tail, this indicates a low global star formation efficiency in the tidal tail producing lower mass star clusters. The H II region that we observed ...

Knierman, Karen; Scowen, Paul; Jansen, Rolf; Wehner, Elizabeth; 10.1088/2041-8205/749/1/L1

2012-01-01

297

On Splitting the Tails Unequally: A New Perspective on One-versus Two-Tailed Tests  

ERIC Educational Resources Information Center

The controversy regarding the admissibility of one-tailed tests of hypotheses was examined. Rather than taking a stand with regard to whether the one-or the two-tailed test is the most seriously flawed, a procedure is developed which can capitalize on the advantages of each. (RC)

Braver, Sanford L.

1975-01-01

298

Collections Conservation.  

ERIC Educational Resources Information Center

Collections conservation is an approach to the preservation treatment of books and book-like materials that is conceptualized and organized in terms of large groups of materials. This guide is intended to enable a library to evaluate its current collections conservation activities. The introduction describes collections conservation and gives…

DeCandido, Robert

299

NESTING HABITAT RELATIONSHIPS OF SYMPATRIC CRESTED CARACARAS, RED-TAILED HAWKS, ANDWHITE-TAILED HAWKS IN SOUTH TEXAS  

Microsoft Academic Search

We quantified nesting-site habitats for sympatric White-tailed Hawks (Buteo albicaudatus )( n 40), Red-tailed Hawks (B. jamaicensis )( n 39), and Crested Caracaras (Caracara cheriway )( n 24) in the Coastal Sand Plain of south Texas. White-tailed Hawks and Crested Caracara nest sites occurred in savannas, whereas Red-tailed Hawk nest sites occurred in woodlands on the edge of savannas. White-tailed

Michael A. Actkinson; WILLIAM P. KUVLESKY JR; Clint W. Boal; Leonard A. Brennan; Fidel Hernandez

2007-01-01

300

THE DUST TAIL OF ASTEROID (3200) PHAETHON  

SciTech Connect

We report the discovery of a comet-like tail on asteroid (3200) Phaethon when imaged at optical wavelengths near perihelion. In both 2009 and 2012, the tail appears {approx}>350'' (2.5 Multiplication-Sign 10{sup 8} m) in length and extends approximately in the projected anti-solar direction. We interpret the tail as being caused by dust particles accelerated by solar radiation pressure. The sudden appearance and the morphology of the tail indicate that the dust particles are small, with an effective radius {approx}1 {mu}m and a combined mass {approx}3 Multiplication-Sign 10{sup 5} kg. These particles are likely products of thermal fracture and/or desiccation cracking under the very high surface temperatures ({approx}1000 K) experienced by Phaethon at perihelion. The existence of the tail confirms earlier inferences about activity in this body based on the detection of anomalous brightening. Phaethon, the presumed source of the Geminid meteoroids, is still active.

Jewitt, David; Li Jing [Department of Earth and Space Sciences, University of California at Los Angeles, 595 Charles Young Drive East, Los Angeles, CA 90095-1567 (United States); Agarwal, Jessica, E-mail: jewitt@ucla.edu [Max Planck Institute for Solar System Research, Max-Planck-Str. 2, D-37191 Katlenburg-Lindau (Germany)

2013-07-10

301

Renal biopsy practice: What is the gold standard?  

PubMed

Renal biopsy (RB) is useful for diagnosis and therapy guidance of renal diseases but incurs a risk of bleeding complications of variable severity, from transitory haematuria or asymptomatic hematoma to life-threatening hemorrhage. Several risk factors for complications after RB have been identified, including high blood pressure, age, decreased renal function, obesity, anemia, low platelet count and hemostasis disorders. These should be carefully assessed and, whenever possible, corrected before the procedure. The incidence of serious complications has become low with the use of automated biopsy devices and ultrasound guidance, which is currently the "gold standard" procedure for percutaneous RB. An outpatient biopsy may be considered in a carefully selected population with no risk factor for bleeding. However, controversies persist on the duration of observation after biopsy, especially for native kidney biopsy. Transjugular RB and laparoscopic RB represent reliable alternatives to conventional percutaneous biopsy in patients at high risk of bleeding, although some factors limit their use. This aim of this review is to summarize the issues of complications after RB, assessment of hemorrhagic risk factors, optimal biopsy procedure and strategies aimed to minimize the risk of bleeding. PMID:25374824

Brachemi, Soumeya; Bollée, Guillaume

2014-11-01

302

Is liver biopsy necessary in the management of alcoholic hepatitis?  

PubMed

Acute alcoholic hepatitis (AAH) is characterised by deep jaundice in patients with a history of heavy alcohol use, which can progress to liver failure. A clinical diagnosis of AAH can be challenging to make in patients without a clear alcohol history or in the presence of risk factors for other causes of acute liver failure. Other causes of acute on chronic liver failure such as sepsis or variceal haemorrhage should be considered. Liver biopsy remains the only reliable method to make an accurate diagnosis. However, there is controversy surrounding the use of liver biopsy in patients with AAH because of the risks of performing a percutaneous biopsy and limitations in access to transjugular biopsy. We review the existing literature and find there are few studies directly comparing clinical and histological diagnosis of AAH. In the small number of studies that have been conducted the correlation between a clinical and histological diagnosis of AAH is poor. Due to this lack of agreement together with difficulties in accessing transjugular liver biopsy outside tertiary referral centres and research institutions, we cannot advocate universal biopsy for AAH but there remains a definite role for liver biopsy where there is clinical diagnostic doubt or dual pathology. It also adds value in a clinical trial context to ensure a homogeneous trial population and to further our understanding of the disease pathology. Further prospective studies are required to determine whether non-invasive markers can be used to accurately diagnose AAH. PMID:24307775

Dhanda, Ashwin D; Collins, Peter L; McCune, C Anne

2013-11-28

303

Renal biopsy practice: What is the gold standard?  

PubMed Central

Renal biopsy (RB) is useful for diagnosis and therapy guidance of renal diseases but incurs a risk of bleeding complications of variable severity, from transitory haematuria or asymptomatic hematoma to life-threatening hemorrhage. Several risk factors for complications after RB have been identified, including high blood pressure, age, decreased renal function, obesity, anemia, low platelet count and hemostasis disorders. These should be carefully assessed and, whenever possible, corrected before the procedure. The incidence of serious complications has become low with the use of automated biopsy devices and ultrasound guidance, which is currently the “gold standard” procedure for percutaneous RB. An outpatient biopsy may be considered in a carefully selected population with no risk factor for bleeding. However, controversies persist on the duration of observation after biopsy, especially for native kidney biopsy. Transjugular RB and laparoscopic RB represent reliable alternatives to conventional percutaneous biopsy in patients at high risk of bleeding, although some factors limit their use. This aim of this review is to summarize the issues of complications after RB, assessment of hemorrhagic risk factors, optimal biopsy procedure and strategies aimed to minimize the risk of bleeding. PMID:25374824

Brachemi, Soumeya; Bollée, Guillaume

2014-01-01

304

Current Concepts in the Biopsy of Musculoskeletal Tumors  

PubMed Central

In the management of bone and soft tissue tumors, accurate diagnosis, using a combination of clinical, radiographic, and histological data, is critical to optimize outcome. On occasion, diagnosis can be made by careful history, physical examination, and images alone. However, the ultimate diagnosis usually depends on histologic analysis by an experienced pathologist. Biopsy is a very important and complex surgery in the staging process. It must be done carefully, so as not to adversely affect the outcome. Technical considerations include proper location and orientation of the biopsy incision and meticulous hemostasis. It is necessary to obtain tissue for a histological diagnosis without spreading the tumor and so compromise the treatment. Furthermore, the surgeon does not open compartmental barriers, anatomic planes, joint space, and tissue area around neurovascular bundles. Nevertheless, avoid producing a hematoma. Biopsy should be carefully planned according to the site and definitive surgery and should be performed by an orthopedic surgeon with an experience in musculoskeletal oncology who will perform the definitive surgery. Improperly done, it can complicate patient care and sometimes even eliminate treatment options. Different biopsy techniques are suitable: fine-needle aspiration, core-needle biopsy, and incisional biopsy. The choice of biopsy depends on the size, the location of the lesion, and the experience of the pathologist. PMID:23844403

Traina, Francesco; Calamelli, Carlotta; Faldini, Cesare

2013-01-01

305

Seeding of tumour cells following breast biopsy: a literature review  

PubMed Central

Needle biopsy of the breast is widely practised. Image guidance ensures a high degree of accuracy. However, sporadic cases of disease recurrence suggest that in some cases the procedure itself may contribute to this complication. This article reviews evidence relating to needle biopsy of the breast and the potential for tumour cell migration into adjacent tissues following the procedure. A literature search was undertaken using Medline, Embase and the Cochrane Library. Results are grouped under three categories: histological evidence of spread, clinical evidence of recurrent disease and the likelihood of seeding dependent upon tumour type. There is histological evidence of seeding of tumour cells from the primary neoplastic site into adjacent breast tissue following biopsy. However, as the interval between biopsy and surgery lengthens then the incidence of seeding declines, which suggests that displaced tumour cells are not viable. Clinical recurrence at the site of a needle biopsy is uncommon and the relationship between biopsy and later recurrence is difficult to confirm. There is some evidence to suggest that cell seeding may be reduced when vacuum biopsy devices are deployed. PMID:21933978

Loughran, C F; Keeling, C R

2011-01-01

306

Better Visualization of Transbronchial Biopsy Using CT Fluoroscopy  

SciTech Connect

Purpose: Computed tomography fluoroscopy (CTF) provides the capability for continuous CT imaging and has been increasingly used in interventional procedures. Our objective was to assess the usefulness of CTF in the monitoring of transbronchial biopsy procedures.Methods: We evaluated nine patients in whom yield of 'conventional' transbronchial biopsies had failed. CTF was performed on a Somatom Plus 4 Power scanner (CARE Vision CT, Siemens, Forchheim, Germany) using 120 kV, 50 mA at a frame rate of eight images per second on a matrix of 256 x 256. Image reconstruction was based on a partial scan with an acquisition time of 0.5 sec. The maximal time without interruption was 79 sec; after stopping for a few seconds a new period of 79 sec was available. The number of biopsies, procedure times, applied dose, and histologic results were documented.Results: With CTF-guided transbronchial biopsy, the yield of the biopsies was improved. In seven patients biopsy yielded bronchial cancer; in one patient histopathologic examination showed tuberculosis. Only in one patient did CTF-guided transbronchial biopsy fail. The mean number of biopsies was four in each patient. Mean fluoroscopy time was 165 {+-} 92 sec (range 111-272 sec) and mean procedure time was 800 {+-} 302 sec (range 480-1081 sec). The applied dose ranged between 500 and 1224 mSv; the mean applied dose was 743 {+-} 414 mSv. There were no fatal complications.Conclusion: Computed tomography fluoroscopy appears to facilitate visualization of transbronchial biopsy procedures, with the drawback of increased radiation exposure. To compare the 'conventional' method versus CTF a randomized prospective study is necessary.

Kickuth, Ralph; Kirchner, Johannes; Laufer, Ulf [Department of Radiology, Marienhospital Herne, University of Bochum, Hoelkeskampring 40, D-44625 Herne (Germany); Sanner, Bernd; Haske, Michael [Department of Medicine, Marienhospital Herne, University of Bochum, Hoelkeskampring 40, D-44625 Herne (Germany); Liermann, Dieter [Department of Radiology, Marienhospital Herne, University of Bochum, Hoelkeskampring 40, D-44625 Herne (Germany)

2000-09-15

307

The precision of three enamel biopsy methods for fluoride determination.  

PubMed

3 different enamel biopsy methods were tested on 2 maxillary permanent incisors on each of 90 schoolchildren. In methods A and B the round biopsy field was bordered by copalite varnish, while method C utilized a scotch tape border. The biopsy itself resulted from etching the enamel surface with 2N perchloric acid for 7 sec for method A, and 14 sec for methods B and C. Flouride was measured with the fluoride activity electrode. The doubled etching time caused only a 30 to 40% increase of enamel removal. Method C showed the best reproducibility. PMID:1225873

Spörri, S; Belser, U; Mühlemann, H R

1975-10-01

308

Collection Mapping and Collection Development.  

ERIC Educational Resources Information Center

Describes the use of collection mapping to assess media collections of Aurora, Colorado, Public Schools. Case studies of elementary, middle, and high school media centers describe materials selection and weeding and identify philosophies that library collections should support school curriculum, and teacher-library media specialist cooperation in…

Murray, William; And Others

1985-01-01

309

Design of tailing dam using red mud  

NASA Astrophysics Data System (ADS)

Red mud, waste industrial product from aluminum industries produced approximately 75 million tonnes every year with less than half of this is used. Storage of this unutilized red mud takes vast tracts of usable land and pollutes, land, air and water. Construction of high embankments, under passes, flyovers, tailing dams uses vast tract of natural resources (top soil) is also matter of concern as its takes thousands of years to form the natural soil. This paper discusses use of red mud for construction of tailing dam based on laboratory findings and finite element analysis. The geotechnical properties such as plasticity, compaction, permeability, shear strength characteristics and dispersion of red mud are presented. Stability and seepage analysis of tailing dams as per finite element analysis using the above geotechnical parameters is presented.

Rout, Subrat K.; Sahoo, Tapaswini; Das, Sarat K.

2013-06-01

310

Plasma irregularities in the comet's tail  

NASA Technical Reports Server (NTRS)

Scintillation theory is invoked to explain fluctuations in radio intensity observed during occultation of the extragalactic radio source PKS 2025-15 by the plasma tail of comet 1973 XII on Jan. 5, 1975. Plasma irregularities and turbulence in the tail of the comet (Kohoutek 1973f) are fitted to a Gaussian spectrum and to a Kolmogorov power-law spectrum in analyzing the scintillation data. The rms fluctuation of electron density in the cometary tail is reported at 80 electrons per cu mm, the inner scale of the fluctuation at 800 km, and the largest scale of fluctuation at possibly 400,000 km. A hump in the comet power-law spectrum is noted. Use of the power spectrum of electron density fluctuations to predict the power spectrum of magnetic field fluctuations for irregularities associated with hydromagnetic turbulence is recommended.

Lee, L. C.

1976-01-01

311

Use of washery tailings in hydrotechnical construction  

SciTech Connect

Dam fill material must be sufficiently homogeneous to with-stand selective displacement. Tests were carried out on typical tailings, involving incremental sampling over periods of one hour, one shift, and one day for analysis. The results showed that the mineral content in the samples taken over 1 hour had the greatest qualitative and quantitative variability; those taken over a 24 hour period, the least. It was found that the tailings showed up well enough in situ, regardless of angle of wetting and internal friction angle. Tailings from Avdeev plant used in a dam and compacted by 4-6 heavy dump truck traverses in 1978. Inspection in 1979 failed to show any cracks or displacement, and filtration was found to be at a low level.

Voznyi, G.F.; Preobazhenskii, B.P.; Mandryka, C.V.; Rozanov, N.N.

1981-01-01

312

Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats  

PubMed Central

Most mammals possess a tail, humans and the Great Apes being notable exceptions. One approach to understanding the mechanisms and evolutionary forces influencing development of a tail is to identify the genetic factors that influence extreme tail length variation within a species. In mice, the Tailless locus has proven to be complex, with evidence of multiple different genes and mutations with pleiotropic effects on tail length, fertility, embryogenesis, male transmission ratio, and meiotic recombination. Five cat breeds have abnormal tail length phenotypes: the American Bobtail, the Manx, the Pixie-Bob, the Kurilian Bobtail, and the Japanese Bobtail. We sequenced the T gene in several independent lineages of Manx cats from both the US and the Isle of Man and identified three 1-bp deletions and one duplication/deletion, each predicted to cause a frameshift that leads to premature termination and truncation of the carboxy terminal end of the Brachyury protein. Ninety-five percent of Manx cats with short-tail phenotypes were heterozygous for T mutations, mutant alleles appeared to be largely lineage-specific, and a maximum LOD score of 6.21 with T was obtained at a recombination fraction (?) of 0.00. One mutant T allele was shared with American Bobtails and Pixie-Bobs; both breeds developed more recently in the US. The ability of mutant Brachyury protein to activate transcription of a downstream target was substantially lower than wild-type protein. Collectively, these results suggest that haploinsufficiency of Brachyury is one mechanism underlying variable tail length in domesticated cats. PMID:23949773

Buckingham, Kati J.; McMillin, Margaret J.; Brassil, Margaret M.; Shively, Kathryn M.; Magnaye, Kevin M.; Cortes, Alejandro; Weinmann, Amy S.; Lyons, Leslie A.; Bamshad, Michael J.

2013-01-01

313

Revegetation and rock cover for stabilization of inactive uranium mill tailings disposal sites. Final report  

SciTech Connect

Guidelines for using vegetation and rock to protect inactive uranium mill tailings from erosion were developed by Pacific Northwest Laboratory as part of the Department of Energy's Uranium Mill Tailings Remedial Action Project (UMTRAP) Technology Development program. Information on soils, climate, and vegetation were collected for 20 inactive tailings sites in the western United States. Sites were grouped according to similarities in climate and vegetation. Soil loss for those sites was characterized using the Universal Soil Loss Equation. Test plots were used to evaluate (1) the interaction between vegetation and sealant barrier systems and (2) the effects of surface rock on soil water and vegetation. Lysimeter and simulation studies were used to direct and support field experiments. 49 references, 17 figures, 16 tables.

Beedlow, P.A.

1984-05-01

314

Monticello Mill Tailings Site environmental report for calendar year 1992  

SciTech Connect

This report contains information pertaining to environmental activities conducted during calendar year 1992 at and near the inactive uranium millsite in Monticello, Utah. Environmental activities conducted at the Monticello Mill Tailings Site (MMTS) during 1992 included those associated with remedial action and compliance monitoring. Compliance monitoring consisted of both radiological and nonradiological monitoring of air, surface water, and ground water. Radiological and nonradiological air monitoring at the MMTS included measurements of atmospheric radon, particulate matter, and gamma radiation. Air particulate monitoring for radiological and nonradiological constituents was conducted at one location on and two locations off the millsite with high-volume particulate samplers. The maximum airborne concentrations of radium-226, thorium-230, and total uranium at all locations were several orders of magnitude below the regulatory limits specified by DOE Order 5400.5. Surface water monitoring included water quality measurements within Montezuma Creek. During 1992, maximum levels of selenium; gross alpha, gross beta, total dissolved solids, and iron exceeded their respective state standards in one or more samples collected from upstream, on-site, and downstream locations. Ground-water monitoring was conducted for two aquifers underlying the millsite. The shallow aquifer is contaminated by leached products of uranium mill tailings. During 1992, Uranium Mill Tailings Radiation Control Act and state of Utah ground-water standards for arsenic, barium, nitrate, chromium, lead, selenium, molybdenum, uranium-234 and -238, gross alpha particle activity, and radium-226 and -228 were exceeded in one or more alluvial wells. This well will continue to be sampled to determine if the presence of these constituents was anomalous or if the measurements represented contamination in the aquifer.

Not Available

1993-05-01

315

Radial tail resolution in the SELEX RICH  

SciTech Connect

The authors use a 7 Million event data sample of 600 GeV/c single track pion events, where the pion track is reconstructed upstream and downstream of the SELEX RICH. They build the RICH ring radius histogram distribution and count the tail events that fall outside 5{sigma}, giving a fraction of 4 x 10{sup -5} events outside the Gaussian tails. This control of events establishes the ability of using the RICH as velocity spectrometer for high precision searches of the K{sup +} {yields} {pi}{sup +} {nu}{bar {nu}} decay like it is planned in the CKM experiment.

Morelos, A.; Mata, J.; Cooper, P.S.; Engelfried, J.; Aguilera-Servin, J.L.; /San Luis Potosi U. /Fermilab

2005-01-01

316

Through the tail of a comet  

NASA Technical Reports Server (NTRS)

The instrumentation, trajectory, and missions of the ISEE-3 spacecraft being sent to observe Comet Giacobini-Zimmer (GZ) are described. Originally parked at a libration point to observe the solar wind, ISEE-3 was directed to perform a complex series of flybys of the earth and the moon to move to a trajectory that will intersect the GZ tail in 1985. Renamed ICE, the spacecraft will record magnetic field and charged particle data on the interaction of the cometary tail with the solar wind.

Mclaughlin, W. I.

1984-01-01

317

Plasma irregularities in the Comet's tail  

NASA Technical Reports Server (NTRS)

The fluctuations in the intensity of radio source PKS 2025-15 during its occultation by Comet Kohoutek (1973f) on January 5, 1974, can be interpreted as scintillations due to the turbulent plasma in the Comet's tail. It was found that the rms fluctuation of the electron density in the Comet's tail is about 200 electrons/cu cm, the inner scale of the fluctuation is about 8 x 10 to the 7th power cm and the largest scale of fluctuation may reach 6 x 10 to the 10th power cm.

Lee, L. C.

1976-01-01

318

An adenovirus linked to mortality and disease in long-tailed ducks (Clangula hyemalis) in Alaska.  

PubMed

An adenovirus was isolated from intestinal samples of two long-tailed ducks (Clangula hyemalis) collected during a die-off in the Beaufort Sea off the north coast of Alaska in 2000. The virus was not neutralized by reference antiserum against known group I, II, or III avian adenoviruses and may represent a new serotype. The prevalence of the virus was determined in live-trapped long-tailed ducks at the mortality site and at a reference site 100 km away where no mortality was observed. Prevalence of adenovirus antibodies in serum samples at the mortality site was 86% compared to 10% at the reference site. Furthermore, 50% of cloacal swabs collected at the mortality site and only 7% of swabs from the reference site were positive for adenoviruses. In 2001, no mortality was observed at either of the study areas, and virus prevalence in both serum and cloacal samples was low, providing further evidence that the adenovirus was linked to the mortality event in 2000. The virus was used to infect long-tailed ducks under experimental conditions and resulted in lesions previously described for avian adenovirus infections and similar to those observed in long-tailed duck carcasses from the Beaufort Sea. The status of long-tailed ducks has recently become a concern in Alaska due to precipitous declines in breeding populations there since the mid-1970s. Our findings suggest that the newly isolated adenovirus is a disease agent and source of mortality in long-tailed ducks, and thus could be a contributing factor in population declines. PMID:14708993

Hollmén, Tuula E; Franson, J Christian; Flint, Paul L; Grand, James B; Lanctot, Richard B; Docherty, Douglas E; Wilson, Heather M

2003-01-01

319

An improved technique for tail-cuff blood pressure measurements with dark-tailed mice.  

PubMed

Study of the genetics of hypertension has been facilitated greatly by the use of mice with modified genes that affect blood pressure. A current successful method for measuring blood pressure in mice relies on detection of light passing through the tail to determine the pressure in a tail-cuff necessary to stop pulsed flow. Success in obtaining reliable blood pressure measurements in light-tailed strains of mice (e.g., C57BL/6J) has been excellent. However, in our and others' experience, mice having highly pigmented tails (e.g., 129S6/SvEvTac) have yielded less consistent measurements. We report here that simple modifications to the channel containing the pulse detection sensor can greatly improve the pulse detection of dark-tailed mice. The first modification--lining the sensor channel with four layers of clear plastic wrap--increased the frequency of successful blood pressure measurements of 129S6/SvEvTac mice twofold and reduced variability by one-third. The second modification--lining the sides of the channel with reflective foil--also improved the success rate with dark-tailed mice. Mean blood pressures were unaffected by these modifications, which enhance detection of the pulse wave and likely will be helpful in diverse applications in which blood pressure is measured in rodent strains with pigmented tails. PMID:16138782

Hagaman, John R; John, Simon; Xu, Lonquan; Smithies, Oliver; Maeda, Nobuyo

2005-09-01

320

Entropy-based heavy tailed distribution transformation and visual analytics for monitoring massive network traffic  

NASA Astrophysics Data System (ADS)

For monitoring network traffic, there is an enormous cost in collecting, storing, and analyzing network traffic datasets. Data mining based network traffic analysis has a growing interest in the cyber security community, but is computationally expensive for finding correlations between attributes in massive network traffic datasets. To lower the cost and reduce computational complexity, it is desirable to perform feasible statistical processing on effective reduced datasets instead of on the original full datasets. Because of the dynamic behavior of network traffic, traffic traces exhibit mixtures of heavy tailed statistical distributions or overdispersion. Heavy tailed network traffic characterization and visualization are important and essential tasks to measure network performance for the Quality of Services. However, heavy tailed distributions are limited in their ability to characterize real-time network traffic due to the difficulty of parameter estimation. The Entropy-Based Heavy Tailed Distribution Transformation (EHTDT) was developed to convert the heavy tailed distribution into a transformed distribution to find the linear approximation. The EHTDT linearization has the advantage of being amenable to characterize and aggregate overdispersion of network traffic in realtime. Results of applying the EHTDT for innovative visual analytics to real network traffic data are presented.

Han, Keesook J.; Hodge, Matthew; Ross, Virginia W.

2011-06-01

321

Construction and preliminary evaluation of copper tailings reclamation test plots at Cyprus Miami Mining Corporation  

SciTech Connect

Twenty pilot-scale test plots were constructed in mid-1998 at the Cyprus Miami mine to investigate the feasibility and cost-effectiveness of various reclamation strategies for establishment of self-sustaining native vegetation on acidic copper tailings. Four reclamation strategies are being tested: (1) directly covering acidic tailings with varying thicknesses f cover soil; (2) removing and/or neutralizing particularly acidic surgical tailings before soil cover placement, (3) chemically and/or physically inhibiting upward water and solute movement using neutralizing and neutral capillary barriers, and (4) constructing a subgrade of neutral tailings beneath cover soil. Preliminary results suggest that thicker soil covers and capillary barrier test plots initially support vegetation to a greater extent than other test plots, probably because of their increased moisture storage capacity. Results also suggest that salts are beginning to migrate upward from underlying tailings into cover soil. Data collected from ongoing vegetation surveys and soil testing will be used to evaluate the effect of various reclamation strategies on vegetation establishment and the potential impact of upward salt migration.

Chammas, G.A.; McCaulou, D.R.; Jones, G.L.

1999-07-01

322

Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan  

Microsoft Academic Search

Background  The Committee for the Standardization of Renal Pathological Diagnosis and the Working Group for Renal Biopsy Database of the\\u000a Japanese Society of Nephrology started the first nationwide, web-based, and prospective registry system, the Japan Renal Biopsy\\u000a Registry (J-RBR), to record the pathological, clinical, and laboratory data of renal biopsies in 2007.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  The patient data including age, gender, laboratory data, and

Hitoshi Sugiyama; Hitoshi Yokoyama; Hiroshi Sato; Takao Saito; Yukimasa Kohda; Shinichi Nishi; Kazuhiko Tsuruya; Hideyasu Kiyomoto; Hiroyuki Iida; Tamaki Sasaki; Makoto Higuchi; Motoshi Hattori; Kazumasa Oka; Shoji Kagami; Michio Nagata; Tetsuya Kawamura; Masataka Honda; Yuichiro Fukasawa; Atsushi Fukatsu; Kunio Morozumi; Norishige Yoshikawa; Yukio Yuzawa; Seiichi Matsuo; Yutaka Kiyohara; Kensuke Joh; Takashi Taguchi; Hirofumi Makino

323

Effect of Horizontal-Tail Span and Vertical Location on the Aerodynamic Characteristics of an Unswept Tail Assembly in Sideslip  

NASA Technical Reports Server (NTRS)

An investigation has been conducted in the Langley stability tunnel on a vertical-tail model with a stub fuselage in combination with various horizontal tails to determine the effect of horizontal-tail span and vertical location of the horizontal tail relative to the vertical tail on the aerodynamic characteristics of an unswept tail assembly in sideslip. The results of the investigation indicated that the induced loading carried by the horizontal tail produced a rolling moment about the point of attachment to the vertical tail which was strongly influenced by horizontal-tail span and vertical locations. The greatest effect of horizontal-tail span on the rolling-moment derivative of the complete tail assembly was obtained for horizontal-tail locations near the top of the vertical tail. Span loadings which were reduced to the static-stability derivatives were calculated for each configuration tested by applying the well-known finite-step method used for wings to the intersecting surfaces of the vertical and horizontal tails. The finite-step method provides a simple and effective means of investigating the span loadings of intersecting surfaces.

Riley, Donald R

1954-01-01

324

Effect of a combined aspiration and core biopsy technique on quality of core bone marrow specimens.  

PubMed

For cases requiring both a bone marrow aspirate and core biopsy, using the same needle and site (i.e., a combined technique) can decrease time, expense, and discomfort compared with the independent (direct) collection of each specimen. The benefits of the combined approach should not be achieved at the expense of specimen quality. In this study, core bone marrow samples obtained from the proximal humerus of 26 dogs by a combined technique immediately posteuthanasia were compared with core samples obtained directly from the opposite humerus. Both core samples from each dog were compared for relative overall quality. Biopsies were unsuccessful in four dogs using the combined technique and in one dog by the direct technique. Marrow length was shorter and hemorrhage artifact was more common using the combined technique. There were no differences in cellularity, megakaryocyte count, the myeloid/erythroid ratio (M/E ratio), iron stores, or diagnostic quality. Direct core biopsy remains the ideal technique; however, the degree of compromise was small in the samples obtained from the combined technique. For clinical patients, the advantages of the combined technique must continue to be weighed against potential loss of diagnostic sensitivity. PMID:23148134

Reeder, Jason P; Hawkins, Eleanor C; Cora, Michelle C; Marks, Steven L; Grindem, Carol B

2013-01-01

325

Reducing breast biopsies by ultrasonographic analysis and a modified self-organizing map  

NASA Astrophysics Data System (ADS)

Recent studies suggest that visual evaluation of ultrasound images could decrease negative biopsies of breast cancer diagnosis. However, visual evaluation requires highly experienced breast sonographers. The objective of this study is to develop computerized radiologist assistant to reduce breast biopsies needed for evaluating suspected breast cancer. The approach of this study utilizes a neural network and tissue features extracted from digital sonographic breast images. The features include texture parameters of breast images: characteristics of echoes within and around breast lesions, and geometrical information of breast tumors. Clusters containing only benign lesions in the feature space are then identified by a modified self- organizing map. This newly developed neural network objectively segments population distributions of lesions and accurately establishes benign and equivocal regions.t eh method was applied to high quality breast sonograms of a large number of patients collected with a controlled procedure at Mayo Clinic. The study showed that the number of biopsies in this group of women could be decreased by 40 percent to 59 percent with high confidence and that no malignancies would have been included in the nonbiopsied group. The advantages of this approach are that it is robust, simple, and effective and does not require highly experienced sonographers.

Zheng, Yi; Greenleaf, James F.; Gisvold, John J.

1997-05-01

326

Validation of Statistical Predictive Models Meant to Select Melanoma Patients for Sentinel Lymph Node Biopsy  

PubMed Central

Introduction To identify melanoma patients at sufficiently low risk of nodal metastases who could avoid SLN biopsy (SLNB). Several statistical models have been proposed based upon patient/tumor characteristics, including logistic regression, classification trees, random forests and support vector machines. We sought to validate recently published models meant to predict sentinel node status. Methods We queried our comprehensive, prospectively-collected melanoma database for consecutive melanoma patients undergoing SLNB. Prediction values were estimated based upon 4 published models, calculating the same reported metrics: negative predictive value (NPV), rate of negative predictions (RNP), and false negative rate (FNR). Results Logistic regression performed comparably with our data when considering NPV (89.4% vs. 93.6%); however the model’s specificity was not high enough to significantly reduce the rate of biopsies (SLN reduction rate of 2.9%). When applied to our data, the classification tree produced NPV and reduction in biopsies rates that were lower 87.7% vs. 94.1% and 29.8% vs. 14.3%, respectively. Two published models could not be applied to our data due to model complexity and the use of proprietary software. Conclusions Published models meant to reduce the SLNB rate among patients with melanoma either underperformed when applied to our larger dataset, or could not be validated. Differences in selection criteria and histopathologic interpretation likely resulted in underperformance. Development of statistical predictive models must be created in a clinically applicable manner to allow for both validation and ultimately clinical utility. PMID:21822550

Sabel, Michael S.; Rice, John D.; Griffith, Kent A.; Lowe, Lori; Wong, Sandra L.; Chang, Alfred E.; Johnson, Timothy M.; Taylor, Jeremy M.G.

2013-01-01

327

A panel of antibodies for identifying squamous metaplasia in endobronchial biopsies from smokers.  

PubMed

Toxic injury can induce squamous metaplasia of respiratory epithelium, which normally is pseudostratified. Terminally differentiated squamous epithelial cells have a flattened, elongated appearance. During differentiation, they have an intermediate phenotype that is difficult to identify and distinguish from tangentially cut columnar cells in tissue sections from endobronchial biopsies, whose small size makes orientation difficult. The aim of our study was to develop a panel of antibodies that could be employed to distinguish normal epithelium from metaplastic epithelium and would be suitable for use on endobronchial biopsies. Nasal polyp tissue and tonsil tissue, which have pseudostratified and squamous epithelia, respectively, were collected from surgical cases and embedded in glycol methacrylate resin. Cut sections were stained immunohistochemically with a panel of antibodies to cytokeratins (CK), whose expression varies with epithelial type and stage of differentiation, and involucrin, a marker of terminal squamous differentiation. Squamous epithelium stained positively for CK5/6, CK13 and involucrin. In the pseudostratified epithelium, basal cells exhibited weak staining for CK13 and strong staining for CK5/6, and columnar cells exhibited strong immunoreactivity for CK7, CK8 and CK18. Application of this panel to endobronchial biopsies from smokers enabled areas of squamous metaplasia to be distinguished from tangentially sectioned epithelium. PMID:20662603

Merrifield, J; O'donnell, R; Davies, D E; Djukanovic, R; Wilson, S J

2011-10-01

328

21 CFR 878.4755 - Absorbable lung biopsy plug.  

...FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4755 Absorbable lung biopsy plug. (a) Identification. A...

2014-04-01

329

Salivary Gland Biopsy Shows Promise to Helping to Diagnose Parkinson's  

MedlinePLUS

Parkinson's HelpLine Learn More Educational Materials Do you want to know more about Parkinson's? PDF's materials provide ... Gland Biopsy Shows Promise to Helping to Diagnose Parkinson’s - Mar 20 2014 A simple outpatient procedure that ...

330

Design of an endoscopic biopsy needle with flexural members  

E-print Network

As a minimally invasive means of extracting a tissue sample from a patient, current endoscopic biopsy needles generally do not preserve tissue histology and often require multiple attempts to obtain a tissue sample. This ...

Figueredo, Stacy L. (Stacy Lee), 1981-

2006-01-01

331

Diffuse intrinsic pontine glioma biopsy: A single institution experience.  

PubMed

Tumor biopsy is rarely performed in diffuse intrinsic pontine glioma (DIPG) due to the presumed risk of surgical complications, although data on the surgery related morbidity of DIPG biopsy is sparse. We performed a retrospective review on 22 consecutive cases of DIPG diagnosed from 2002 to 2012 at Children's Hospital of Michigan, 15 of which underwent biopsy. Transient new or worsening neurological deficits were observed in three of 15 cases following surgery. No surgery related mortality or permanent deficit was observed, and the mean overall survival was 10.4?±?3.8 months. Undergoing biopsy did not adversely affect the outcome. Pediatr Blood Cancer 2015;62:163-165. © 2014 Wiley Periodicals, Inc. PMID:25263768

Wang, Zhihong J; Rao, Latha; Bhambhani, Kanta; Miller, Kathy; Poulik, Janet; Altinok, Deniz; Sood, Sandeep

2015-01-01

332

A tissue stabilization device for MRI-guided breast biopsy.  

PubMed

We present a breast tissue stabilization device that can be used in magnetic resonance imaging-guided biopsy. The device employs adjustable support plates with an optimized geometry to minimize the biopsy target displacement using smaller compression than the conventional parallel plates approach. It is expected that the reduced compression will cause less patient discomfort and improve image quality by enhancing the contrast intake. Precomputed optimal positions of the stabilization plates for a given biopsy target location are provided in a look-up table. The results of several experiments with a prototype of the device carried out on chicken breast tissue demonstrate the effectiveness of the new design when compared with conventional stabilization methods. The proposed stabilization mechanism provides excellent flexibility in selecting the needle insertion point and can be used in manual as well as robot-assisted biopsy procedures. PMID:25023957

Patriciu, Alexandru; Chen, Maggie; Iranpanah, Behzad; Sirouspour, Shahin

2014-09-01

333

Skin and conjunctival biopsies in infantile neuroaxonal dystrophy.  

PubMed

The diagnosis of infantile neuro-axonal dystrophy (INAD) in a 5-year-old patient was confirmed by the ultrastructural study of neuromuscular, skin and conjunctival biopsy specimens. Abnormal networks of smooth membranous, lamellar and tubular profiles were found in presynaptic terminals and in conjunctival and dermal axons. INAD is the first neurological disease outside the group of storage disorders in which skin and conjunctival biopsies contribute significiantly to the diagnosis. PMID:442990

Martin, J J; Leroy, J G; Libert, J; van Eygen, M; Logghe, N

1979-03-15

334

Diagnosis of infantile neuroaxonal dystrophy by conjunctival biopsy.  

PubMed

Conjunctival biopsy and ultrastructural examination of conjunctival nerves, showing the presence of spheroids within axons, led to the confirmation of the diagnosis of infantile neuroaxonal dystrophy in two children with progressive mental deterioration. Conjunctival biopsy, which is simple to perform, even in young children, and does not require general anaesthesia or admission to hospital, is presented as a reliable and very convenient technique for the diagnosis of infantile neuroaxonal dystrophy. PMID:671062

Arsénio-Nunes, M L; Goutières, F

1978-06-01

335

Effect of local anesthetics on patient recovery after transrectal biopsy  

Microsoft Academic Search

Objectives. To determine the analgesic efficacy of local anesthetics injected lateral to the seminal vesicles before prostate biopsy, during and immediately after the procedure, because pain is a common side effect of transrectal ultrasound-guided prostate biopsy.Methods. Patients were randomized to receive 5 mL of either 1% lidocaine or sterile normal saline injected (under ultrasound guidance) lateral to the seminal vesicles

Christopher L Wu; H. Ballentine Carter; Mohammad Naqibuddin; Lee A Fleisher

2001-01-01

336

Acute bacterial prostatitis after transrectal prostate needle biopsy: clinical analysis  

Microsoft Academic Search

We investigated the incidence and characteristics of acute bacterial prostatitis after transrectal prostate biopsy, based\\u000a on urine and blood cultures, treatment method, and outcome. Four hundred and fifty-seven patients who underwent transrectal\\u000a prostate biopsy in our hospital between November 2003 and October 2006 were reviewed. These patients were treated with 200\\u000a mg levofloxacin orally twice daily for 4 days, beginning

Kazuyoshi Shigehara; Tohru Miyagi; Takao Nakashima; Masayoshi Shimamura

2008-01-01

337

Evaluation of electronic biopsy for clinical diagnosis in virtual colonoscopy  

NASA Astrophysics Data System (ADS)

Virtual colonoscopy provides techniques not available in optical colonoscopy, an exciting one being the ability to perform an electronic biopsy. An electronic biopsy image is created using ray-casting volume rendering of the CT data with a translucent transfer function mapping higher densities to red and lower densities to blue. The resulting image allows the physician to gain insight into the internal structure of polyps. Benign tissue and adenomas can be differentiated; the former will appear as homogeneously blue and the latter as irregular red structures. Although this technique is now common, is included with clinical systems, and has been used successfully for computer aided detection, there has so far been no study to evaluate the effectiveness of a physician using electronic biopsy in determining the pathological state of a polyp. We present here such a study, wherein an experienced radiologist ranked polyps based on electronic biopsy alone per scan (supine and prone), as well as both combined. Our results show a correct identification 77% of the time using prone or supine images alone, and 80% accuracy using both. Using ROC analysis based on this study with one reader and a modest sample size, the combined score is not significantly higher than using a single electronic biopsy image alone. However, our analysis indicates a trend of superiority for the combined ranking that deserves a follow-up confirmatory study with a larger sample and more readers. This study yields hope that an improved electronic biopsy technique could become a primary clinical diagnosis method.

Marino, Joseph; Du, Wei; Barish, Matthew; Li, Ellen; Zhu, Wei; Kaufman, Arie

2011-03-01

338

Risk Factors and Timing of Native Kidney Biopsy Complications  

PubMed Central

Background The appropriate observation period, rate and risk factors of complications after a percutaneous renal biopsy remain debated. Methods We retrospectively studied native kidney biopsies performed in our institution between January 2007 and July 2011. Outpatients had either an 8- (67%) or a 24-hour (33%) observation period. Results 312 biopsies were reviewed (287 patients), 51% of patients were female and the mean age was 54 ± 15 years. Half of these biopsies were performed in outpatients. A total of 15% of patients developed a symptomatic hematoma, 9% received a red blood cell transfusion and 1% required an angio-intervention. Eighty-four percent of the complications manifested within the first 8 h, 86% at 12 h and 94% at 24 h. Outpatients experienced significantly less complications, all manifesting within the first 8 h, 14% required an observation period longer than planned. The risk of symptomatic hematoma increased to 11, 20, 35 and 40% in patients with >200, 140-200, 100-140 and <100 × 109/l platelets, respectively (p = 0.002). It also increased in hemodialysis patients (29% compared to 14%, p = 0.02). We found no association of risk with the number of biopsy passes and only a trend with needle size. Conclusion Symptomatic hematomas occurred in 15% of kidney biopsies and were strongly associated with platelet count and hemodialysis. Outpatients experienced fewer complications; therefore, we can conclude that same-day discharge in selected patients is safe. PMID:24803920

Simard-Meilleur, Marie-Christine; Troyanov, Stephan; Roy, Louise; Dalaire, Etienne; Brachemi, Soumeya

2014-01-01

339

Flight costs of long, sexually selected tails in hummingbirds.  

PubMed

The elongated tails adorning many male birds have traditionally been thought to degrade flight performance by increasing body drag. However, aerodynamic interactions between the body and tail can be substantial in some contexts, and a short tail may actually reduce rather than increase overall drag. To test how tail length affects flight performance, we manipulated the tails of Anna's hummingbirds (Calypte anna) by increasing their length with the greatly elongated tail streamers of the red-billed streamertail (Trochilus polytmus) and reducing their length by removing first the rectrices and then the entire tail (i.e. all rectrices and tail covert feathers). Flight performance was measured in a wind tunnel by measuring (i) the maximum forward speed at which the birds could fly and (ii) the metabolic cost of flight while flying at airspeeds from 0 to 14 m s(-1). We found a significant interaction effect between tail treatment and airspeed: an elongated tail increased the metabolic cost of flight by up to 11 per cent, and this effect was strongest at higher flight speeds. Maximum flight speed was concomitantly reduced by 3.4 per cent. Also, removing the entire tail decreased maximum flight speed by 2 per cent, suggesting beneficial aerodynamic effects for tails of normal length. The effects of elongation are thus subtle and airspeed-specific, suggesting that diversity in avian tail morphology is associated with only modest flight costs. PMID:19324747

Clark, Christopher James; Dudley, Robert

2009-06-01

340

Flight costs of long, sexually selected tails in hummingbirds  

PubMed Central

The elongated tails adorning many male birds have traditionally been thought to degrade flight performance by increasing body drag. However, aerodynamic interactions between the body and tail can be substantial in some contexts, and a short tail may actually reduce rather than increase overall drag. To test how tail length affects flight performance, we manipulated the tails of Anna's hummingbirds (Calypte anna) by increasing their length with the greatly elongated tail streamers of the red-billed streamertail (Trochilus polytmus) and reducing their length by removing first the rectrices and then the entire tail (i.e. all rectrices and tail covert feathers). Flight performance was measured in a wind tunnel by measuring (i) the maximum forward speed at which the birds could fly and (ii) the metabolic cost of flight while flying at airspeeds from 0 to 14?m?s?1. We found a significant interaction effect between tail treatment and airspeed: an elongated tail increased the metabolic cost of flight by up to 11 per cent, and this effect was strongest at higher flight speeds. Maximum flight speed was concomitantly reduced by 3.4 per cent. Also, removing the entire tail decreased maximum flight speed by 2 per cent, suggesting beneficial aerodynamic effects for tails of normal length. The effects of elongation are thus subtle and airspeed-specific, suggesting that diversity in avian tail morphology is associated with only modest flight costs. PMID:19324747

James Clark, Christopher; Dudley, Robert

2009-01-01

341

Collective Enumeration  

ERIC Educational Resources Information Center

Many joint decisions in everyday life (e.g., Which bar is less crowded?) depend on approximate enumeration, but very little is known about the psychological characteristics of counting together. Here we systematically investigated collective approximate enumeration. Pairs of participants made individual and collective enumeration judgments in a…

Bahrami, Bahador; Didino, Daniele; Frith, Chris; Butterworth, Brian; Rees, Geraint

2013-01-01

342

Characterization of Adherent Bacteroidales from Intestinal Biopsies of Children and Young Adults with Inflammatory Bowel Disease  

PubMed Central

There is extensive evidence implicating the intestinal microbiota in inflammatory bowel disease [IBD], but no microbial agent has been identified as a sole causative agent. Bacteroidales are numerically dominant intestinal organisms that associate with the mucosal surface and have properties that both positively and negatively affect the host. To determine precise numbers and species of Bacteroidales adherent to the mucosal surface in IBD patients, we performed a comprehensive culture based analysis of intestinal biopsies from pediatric Crohn's disease [CD], ulcerative colitis [UC], and control subjects. We obtained biopsies from 94 patients and used multiplex PCR or 16S rDNA sequencing of Bacteroidales isolates for species identification. Eighteen different Bacteroidales species were identified in the study group, with up to ten different species per biopsy, a number higher than demonstrated using 16S rRNA gene sequencing methods. Species diversity was decreased in IBD compared to controls and with increasingly inflamed tissue. There were significant differences in predominant Bacteroidales species between biopsies from the three groups and from inflamed and uninflamed sites. Parabacteroides distasonis significantly decreased in inflamed tissue. All 373 Bacteroidales isolates collected in this study grew with mucin as the only utilizable carbon source suggesting this is a non-pathogenic feature of this bacterial order. Bacteroides fragilis isolates with the enterotoxin gene [bft], previously associated with flares of colitis, were not found more often at inflamed colonic sites or within IBD subjects. B. fragilis isolates with the ability to synthesize the immunomodulatory polysaccharide A [PSA], previously shown to be protective in murine models of colitis, were not detected more often from healthy versus inflamed tissue. PMID:23776434

Zitomersky, Naamah L.; Atkinson, Benjamin J.; Franklin, Sarah W.; Mitchell, Paul D.; Snapper, Scott B.; Comstock, Laurie E.; Bousvaros, Athos

2013-01-01

343

MR-guided biopsy of the breast after lumpectomy and radiation therapy using two methods of immobilization in the lateral decubitus position.  

PubMed

We describe two methods of breast immobilization using the lateral decubitus position to increase patient comfort and access to the axillary tail for MR-guided biopsy in the postsurgical or irradiated breast. The first method uses a compression device with good immobilization but poor patient tolerance. The second approach uses a thermoplastic mesh material to form a rigid exoskeleton around the breast: immobilization is adequate and patient acceptability is good. The latter method is preferred and requires formal evaluation in larger scale trials. PMID:8574035

deSouza, N M; Kormos, D W; Krausz, T; Coutts, G A; Hall, A S; Burl, M; Schwieso, J E; Puni, R; Vernon, C

1995-01-01

344

Experiments on a Tail-wheel Shimmy  

NASA Technical Reports Server (NTRS)

Model tests on the "running belt" and tests with a full-scale tail wheel were made on a rotating drum as well as on a runway in order to investigate the causes of the undesirable shimmy phenomena frequently occurring on airplane tail wheels, and the means of avoiding them. The small model (scale 1:10) permitted simulation of the mass, moments of inertia, and fuselage stiffness of the airplane and determination of their influence on the shimmy, whereas by means of the larger model with pneumatic tires (scale 1:2) more accurate investigations were made on the tail wheel itself. The results of drum and road tests show good agreement with one another and with model values. Detailed investigations were made regarding the dependence of the shimmy tendency on trail, rolling speed, load, size of tires, ground friction,and inclination of the swivel axis; furthermore, regarding the influence of devices with restoring effect on the tail wheel, and the friction damping required for prevention of shimmy. Finally observations from slow-motion pictures are reported and conclusions drawn concerning the influence of tire deformation.

Harling, R; Dietz, O

1954-01-01

345

Helicopter tail rotor orthogonal blade vortex interaction  

Microsoft Academic Search

The aerodynamic operating environment of the helicopter is particularly complex and, to some extent, dominated by the vortices trailed from the main and tail rotors. These vortices not only determine the form of the induced flow field but also interact with each other and with elements of the physical structure of the flight vehicle. Such interactions can have implications in

F. N. Coton; J. S. Marshall; R. A. Mc D. Galbraith; R. B. Green

2004-01-01

346

Dispersal in female white-tailed deer  

USGS Publications Warehouse

Seven of 35 yearling female white-tailed deer (Odocoileus virginianus) in a migratory herd in northeastern Minnesota dispersed 18-168 km from natal ranges during late May through June. Dispersal as a proximate event appears voluntary and independent of deer density.

Nelson, M. E.; Mech, L. D.

1992-01-01

347

Magnetic field controls carbon arc tail flame  

NASA Technical Reports Server (NTRS)

Polarity of two electromagnets placed near the exhaust flue cancels out a high carbon-arc field. The arc tail flame is correctly drawn to the exhaust flue and contamination is diverted. This device should reduce maintenance cycles on any arc-powered illuminator.

1965-01-01

348

VideoLab: Heads and Tails  

NSDL National Science Digital Library

The flatworms known as planaria are proverbial for their ability to regenerate a head or tail properly when amputated (first clip in movie). But how does the organism "know" which end to regenerate? Gurley et al. found an answer in a molecular "switch", beta-catenin, a protein that regulates a variety of cell processes during development.

Kyle A. Gurley (Howard Hughes Medical Institute, University of Utah School of Medicine;Department of Neurobiology and Anatomy); Jochen C. Rink (Howard Hughes Medical Institute, University of Utah School of Medicine;Department of Neurobiology and Anatomy); Alejandro Sánchez Alvarado (Howard Hughes Medical Institute, University of Utah School of Medicine;Department of Neurobiology and Anatomy)

2008-01-18

349

The Long Tail Takes Over Music  

Microsoft Academic Search

Former software developer and independent musician Jonathan Coulton has forged a following and a living wage by leveraging the Internet, and he's still pondering how the new business model for the music industry will emerge. However, the music business's very foundation is antithetical to long-tail economics.

Greg Goth

2007-01-01

350

Kinesin Tail Domains Are Intrinsically Disordered  

PubMed Central

Kinesin motor proteins transport a wide variety of molecular cargoes in a spatially and temporally regulated manner. Kinesin motor domains, which hydrolyze ATP to produce a directed mechanical force along a microtubule, are well conserved throughout the entire superfamily. Outside of the motor domains, kinesin sequences diverge along with their transport functions. The non-motor regions, particularly the tails, respond to a wide variety of structural and molecular cues that enable kinesins to carry specific cargoes in response to particular cellular signals. Here, we demonstrate that intrinsic disorder is a common structural feature of kinesins. A bioinformatics survey of the full-length sequences of all 43 human kinesins predicts that significant regions of intrinsically disordered residues are present in all kinesins. These regions are concentrated in the non-motor domains, particularly in the tails and near sites for ligand binding or post-translational modifications. In order to experimentally verify these predictions, we expressed and purified the tail domains of kinesins representing three different families (Kif5B, Kif10, and KifC3). Circular dichroism (CD) and NMR spectroscopy experiments demonstrate that the isolated tails are disordered in vitro, yet they retain their functional microtubule-binding activity. Based on these results, we propose that intrinsic disorder is a common structural feature that confers functional specificity to kinesins. PMID:22674872

Seeger, Mark A.; Zhang, Yongbo; Rice, Sarah E.

2012-01-01

351

Estimating Bivariate Tails Elena Di Bernardino  

E-print Network

Estimating Bivariate Tails Elena Di Bernardino Universit´e de Lyon, Universit´e Lyon 1, ISFA, Laboratoire SAF. E-mail : elena.di-bernardino@univ-lyon1.fr V´eronique Maume-Deschamps Universit´e de Lyon

Paris-Sud XI, Université de

352

TAIL-MOUNTED RADIO TRANSMITTERS FOR WATERFOWL  

Microsoft Academic Search

We successfully tested tail-mounted radio transmitters on Pink-footed Geese (Anser brachyrhynchus), Barnacle Geese (Branta leucopsis), Brant (Branta bernicla) and Eur- asian Wigeon (Anas penelope). The range of detection of the transmitters was approximately 1 km and some birds were tracked for up to 4 mo. Movements and activity of the birds were not affected by the packages. We conclude that

JEAN-FRANCOIS GIROUX; DAVID V. BELL; STEVE PERCIVAL; RON W. SUMMERS

353

Molasses Tail in Dense Hard Core Fluids  

NASA Astrophysics Data System (ADS)

The long slow decaying potential part of the shear-stress autocorrelation function has been called the ``molasses tail'' to differentiate it from the hydrodynamic origin of the long time tail in the velocity autocorrelation function and to emphasize its relation to the highly viscous glassy state [1]. Some twenty years ago, the molasses tail in dense liquids near the solid-fluid transition point was speculated to be due to transient crystal nuclei formation [2].This slow decaying process of the OACF and its decomposition (pair, triplet, and quadruplet) is a key factor in understanding the onset of the glass transition. With additional computer power, we are now investigating the origin of the molasses tail using a modern fast algorithm based on event-driven Molecular Dynamics (MD) simulation.We confirm the non-algebraic decay (stretched exponential) at intermediate times corresponding to the existence of various cluster sizes a solid cluster at high densities. The decay in dense systems thus consists of a three stage relaxation process, which are the kinetic regime, the molasses regime and the diffusional power regime[3]. [1] B. J. Alder, in Molecular Dynamics Simulation of Statistical-mechanical Systems, G. Ciccotti and W. G. Hoover, eds.(North-Holland, Amsterdam, 1986) 66. [2] A. J. C. Ladd, and B. J. Alder, J. Stat. Phys. 57, 473 (1989). [3] M. Isobe and B. J. Alder, Mol. Phys., 107, 609 (2009).

Isobe, Masaharu; Alder, Berni

2010-03-01

354

Approximating Tail Areas of Probability Distributions  

Microsoft Academic Search

A general method for approximating tail areas is developed through an extension of the methodology of Andrews. This extension is applied to both continuous and discrete distributions. Examples of the approximations are given for the standard normal, $t$, and chi-square distributions in the continuous case and for the Poisson and binomial distributions in the discrete case. Errors of the approximations

Alan J. Gross; David W. Hosmer

1978-01-01

355

Investigation of environmental impacts of tailings dams  

Microsoft Academic Search

Mining has been one of the key sectors for industrialisation of the world for centuries. As the mining activities enlarge, the amount of waste materials readily increases. Storage of waste materials or tailings disposal has become a serious matter for the mining industry due to its enlargement especially for the last 30 years. During the beneficiation of valuable metals and

Safak Ozkan; Bedri Ipekoglu

2002-01-01

356

A TALE OF FOUR UPSTREAM TAILINGS DAMS  

Microsoft Academic Search

The evaluation and performance of four upstream-constructed tailings dams in South America are presented. All four dams were constructed beginning in the 1990's. The juxtaposition of the same design to four sites, each with unique site and operating conditions, led not surprisingly to four different outcomes. These outcomes ranged from outright failure, to construction of a toe buttress, slope flattening,

T. E. Martin; E. C. McRoberts; M. P. Davies

357

Study Of Helicopter-Tail-Rotor Noise  

NASA Technical Reports Server (NTRS)

Report describes findings of experiment in generation of impulsive noise and fluctuating blade loads by helicopter tail rotor interacting with vortexes from main rotor. Experiment used model rotor and isolated vortex and designed to isolate blade/vortex interaction noise from other types of rotor noise.

Ahmadi, Ali R.; Beranek, Bolt

1988-01-01

358

New Mixed Tail Triphenylene Discotic Liquid Crystals  

Microsoft Academic Search

Some new mixed tail triphenylene discotic liquid crystals having three alkoxy and three alkanoyloxy chains have been prepared and characterized. Effects of unsymmetrical substitution by virtue of different alkyl chains in the periphery and their attachment to the core were studied. The synthesis was carried out by esterification of the symmetrical and unsymmetrical trihydroxy-tripentyloxytriphenylenes with various acid chlorides. All the

M. Manickam; Sandeep Kumar

1999-01-01

359

Real time video processing software for the analysis of endoscopic guided-biopsies  

NASA Astrophysics Data System (ADS)

The severity in Barrett esophagus disease is, undoubtedly, the possibility of its malignization. To make an early diagnosis in order to avoid possible complications, it is absolutely necessary collect biopsies to make a histological analysis. This should be done under endoscopic control to avoid mucus areas that may co-exist within the columnar epithelial, which could lead to a false diagnosis. This paper presents a video processing software in real-time in order to delineate and enhance areas of interest to facilitate the work of the expert.

Ordoñez, C.; Bouchet, A.; Pastore, J.; Blotta, E.

2011-12-01

360

Management of rising prostate-specific antigen after a negative biopsy.  

PubMed

Prostate biopsy remains one of the most commonly performed urologic office procedures. A significant percentage of men with a negative result may have unrecognized disease. Inadequate biopsy strategies or findings of high-grade prostatic intraepithelial neoplasia or atypia increase this likelihood. The term "negative biopsy" may be misleading. Traditional sextant biopsy is inaccurate and extended- or saturation-biopsy protocols miss small cancers. A rising prostate-specific antigen (PSA) after a negative prostate biopsy may indicate undiagnosed cancer. Magnetic resonance imaging (MRI) and template-guided biopsy have been proposed as diagnostic adjuncts in this setting. Medical manipulation has met with limited acceptance in this setting. In the presence of a rising PSA after a negative biopsy a low threshold for repeat biopsy should be entertained. Saturation biopsy increases cancer detection, especially in patients with more than two prior biopsies. Adjuncts to improve cancer detection, such as administration of 5-?-reductase inhibitors and MRI, are promising. PMID:21344195

Levy, David A; Jones, J Stephen

2011-06-01

361

Collective Enumeration  

PubMed Central

Many joint decisions in everyday life (e.g., Which bar is less crowded?) depend on approximate enumeration, but very little is known about the psychological characteristics of counting together. Here we systematically investigated collective approximate enumeration. Pairs of participants made individual and collective enumeration judgments in a 2-alternative forced-choice task and when in disagreement, they negotiated joint decisions via verbal communication and received feedback about accuracy at the end of each trial. The results showed that two people could collectively count better than either one alone, but not as well as expected by previous models of collective sensory decision making in more basic perceptual domains (e.g., luminance contrast). Moreover, such collective enumeration benefited from prior, noninteractive practice showing that social learning of how to combine shared information about enumeration required substantial individual experience. Finally, the collective context had a positive but transient impact on an individual's enumeration sensitivity. This transient social influence may be explained as a motivational factor arising from the fact that members of a collective must take responsibility for their individual decisions and face the consequences of their judgments. PMID:22889187

Bahrami, Bahador; Didino, Daniele; Frith, Chris; Butterworth, Brian; Rees, Geraint

2012-01-01

362

Tail and Ionospheric Signatures of Tail Fast Flows Associated with PBIs and with Substorms  

NASA Astrophysics Data System (ADS)

Earthward convection of the tail plasma sheet is often organized in bursts of fast ion flows restricted in azimuthally narrow channels. It has been shown that Auroral Poleward Boundary Intensifications (PBIs) are often the ionospheric signature of such fast flow channels in the midtail. Equatorward flow bursts have been observed in the ionosphere, and have been shown to be the ionospheric mapping of the tail fast flow channels in few case studies. We focus on identifying such ionospheric signatures and understanding the physics of this magnetosphere-ionosphere interaction via conjunctions of the THEMIS probes with the Sondrestrom radar. We find fundamental differences between the tail fast flows that are associated with substorm onsets and those associated with PBIs, as well as between their respective ionospheric flow signatures. The tail fast flows that produce PBIs are observed in the midtail. They do not typically penetrate to the inner magnetosphere and they are accompanied by plasma sheet expansion signatures in the mid tail. No dipolarization signatures are observed in the inner magnetosphere. The ionospheric signatures associated with such tail flows are PBI- type aurora and substantially enhanced equatorward flows. Tail fast flows that are associated with substorm onsets are typically observed only by the inner magnetosphere probes, only occasionally being seen also in the midtail. Clear dipolarizations are seen with such flows in the inner magnetosphere but not in the midtail. The ionospheric flow associated with such tail fast flows is far distinct, enhanced westward flows being occasionally seen at the higher latitude part of the Sondrestrom field of view with enhanced eastward flows observed at the lower latitudes. Enhanced equatorward flows are not seen.

Shi, Y.; Zesta, E.; Lyons, L.; Angelopoulos, V.; Donovan, E.; McFadden, J.; Carlson, C.; Glassmeier, K.; Mende, S.

2009-05-01

363

Microscale mineralogical characterization of As, Fe, and Ni in uranium mine tailings  

NASA Astrophysics Data System (ADS)

Uranium (U) ores can contain high concentrations of elements of concern (EOCs), such as arsenic (As) and nickel (Ni) present in sulfide and arsenide minerals. The U in these ores is often solubilized by adding H2SO4 to attain a pH ?1 under oxic conditions. This process releases some EOCs from the primary minerals into solution. The barren raffinate (solution remaining after U extraction) is subsequently neutralized with Ca(OH)2 to a terminal pH of ?10.5, resulting in a reduction in the aqueous concentrations of the EOCs. These neutralized raffinates are mixed with the non-reacted primary minerals and discharged as tailing into tailings management facilities (TMFs). To aid in the accurate characterization and quantification of the mineralogical controls on the concentrations of EOCs in the tailings porewater, their spatial distribution and speciation were studied at the micron scale in tailings samples collected from the Deilmann U Tailings Management Facility (DTMF), northern Saskatchewan, Canada. Backscattered electron images of the tailings samples generated using an electron microprobe show the presence of nodules (10-200 ?m size) surrounded by bright rims. Wavelength dispersive spectrometric (WDS) and synchrotron-based micro-X-ray fluorescence (?-XRF) elemental mapping show that the nodules are dominated by Ca and S (as gypsum) and the bright rims are dominated by Fe, As, and Ni. Micro-X-ray absorption near-edge structure (?-XANES) spectra collected within and near the rims indicate that the Fe and Ni are present mainly in the +3 and +2 oxidation states, respectively; for As, the +5 oxidation state dominates but significant amounts of the +3 oxidation state are present in some areas. Linear combination fit analyses of the K-edges for the Fe, As, and Ni ?-XANES spectra to reference compounds suggest the Fe in the rims is present as ferrihydrite with As and Ni are adsorbed to it. Energy dispersive spectrometric (EDS) data indicate that isolated, highly reflective particles distributed throughout the tailings matrix are primary As-, Cu-, Fe-, and Ni-bearing minerals. Geochemical modeling of the neutralization process shows that the nodules (gypsum) formed at pH ?1 and acted as a substrate for the precipitation of ferrihydrite at pH ?3.4. The As and Ni subsequently adsorb to the ferrihydrite. Overall, the microscale data suggest that the As and Ni adsorbed onto the ferrihydrite should remain stable for many years and continue to the control the Fe, As, and Ni concentrations in the tailings porewater.

Essilfie-Dughan, Joseph; Hendry, M. Jim; Warner, Jeff; Kotzer, Tom

2012-11-01

364

Method for treating oil sands extraction plant tailings  

SciTech Connect

Tailings from an oil sands hot water process extraction plant are mixed with hydrolyzed starch flocculant and transferred to a settling pond. After a residence period on the order of one year, sludge from the lower region of the settling pond is withdrawn, mixed with a hydrolyzed starch dewatering agent and transferred to a collecting pond. After a residence period on the order of one week, partially dewatered sludge is withdrawn, mixed with sand, and deposited in a terminal disposal area, the sand in the mixture there effecting an internal surcharge to obtain further dewatering. The hydrolyzed starch additives are obtained by the aqueous hydrolysis of a starch in the presence of one or more metal salts.

Yong, R.N.

1984-03-20

365

Micrometeorite Collecting  

ERIC Educational Resources Information Center

Describes how to collect micrometeorites and suggests a number of related activities such as determining the number of meteors entering the atmosphere and determining the composition of the micrometeorites. (BR)

Toubes, Joe; Hoff, Darrel

1974-01-01

366

Spoon Collective  

NSDL National Science Digital Library

The Spoon Collective houses descriptive information, discussion archives, paper archives, and links to Websites for three dozen listservs related to the discussion of philosophy, sociology, political science, and literary theory. Some of the topics for the lists include Postcolonialism, Poststructuralism, Feminism, Marxism, and Cultural Studies. Thirteen of the lists are dedicated to the work of influential thinkers, including Jean Baudrillard, Pierre Bourdieu, Michel Foucault, Friedrich Nietzsche, and Martin Heidegger. All content at the Spoon Collective can be searched aggregately.

367

Aquatic Plant Establishment on Nickel Tailings Five Years After Flooding  

Microsoft Academic Search

Nickel tailings were deposited between 1978 and 1988 in Falconbridge's New Tailings Area located northeast of Sudbury, Ontario, Canada. In 1996, construction of a new dam and dredging split the site into an Upper Terrace (56 ha) and a Lower Terrace (30 ha) to facilitate flooding. Water covers minimize the oxidation of acid generating tailings but some oxidation and release

F. Wilkinson; P. J. Beckett

368

The Tail-less Cat in Free-Fall.  

ERIC Educational Resources Information Center

Describes four kinds of movement by a cat with or without angular momentum and tail or tail-less during free falling. Presents many pictures illustrating the movement. Supports the position that the angular momentum of the tail plays an important role in free fall. (YP)

Fredrickson, J. E.

1989-01-01

369

TECHNICAL NOTE Individual identification of Sitka black-tailed deer  

E-print Network

TECHNICAL NOTE Individual identification of Sitka black-tailed deer (Odocoileus hemionus sitkensis for extracting DNA from fecal pellets from Sitka black-tailed deer (Odocoileus hemionus sitkensis) and evaluated. Keywords Alaska Á DNA Á Feces Á Microsatellites Á Odocoileus hemionus sitkensis Á Sitka black-tailed deer

370

G-tail telomere HPA: simple measurement of  

E-print Network

G-tail telomere HPA: simple measurement of human single-stranded telomeric overhangs Hidetoshi of telomeric 3¢-overhang (G-tail) lengths is essential for investigation of the biological effects of telomere dysfunction. G-tail telomere hybridization protection assay (Gt-telomere HPA) has the advantages of being

Cai, Long

371

REMEDIATION OF ACID MINE TAILINGS AND RECOVERY OF COPPER  

Microsoft Academic Search

An interdisciplinary team of students from New Mexico State University has developed a solution to Task I of the 1998 WERC Environmental Design Contest. The proposed process addresses the treatment of mine tailings which generate acid and the recovery of metals contained in the tailings. The objective of the design is to recover and transport the mine tailings in a

Ali Al-Matar; Jennifer Alwin; David Rockstraw

372

Environmental desulphurization of four Canadian mine tailings using froth flotation  

Microsoft Academic Search

Environmental desulphurization is an attractive alternative for management of acid generating tailings. This process placed at the end of the primary process treatment circuit will reduce a large amount of the problematic tailings by concentrating the sulphide fraction. To produce desulphurized tailings, non-selective froth flotation is the most adapted method. The desulphurization level is fixed by the sulphide content of

M Benzaazoua; B Bussière; M Kongolo; J McLaughlin; P Marion

2000-01-01

373

IMPACT PREDICTION OF THE REACTIVATION OF AN UNUSED TAILINGS DAM  

Microsoft Academic Search

A frequent occurrence in areas with a long history of mining is the reactivation of mine residue deposits. This paper presents an impact prediction study conducted for the reactivation of a gold tailings dam. Two phases of new tailings deposition are proposed. The objective of the study was to assess the potential impact on downstream groundwater quality. The tailings dam

TERRY HARCK; BERNADETTE AZZIE; CATRIONA COYLE; TALITA GERMISHUYSE; RAVI VADAPALLI; ALBERT VAN ZYL

374

Management and Conservation Immobilization of White-Tailed Deer With  

E-print Network

and effective alternative for immobilization of white-tailed deer (Odocoileus virginianus). During a 2-stage Society. KEY WORDS anesthesia, ketamine, Odocoileus virginianus, telazol, tolazoline, white-tailed deer and Wilson 2002). Currently, few drug combinations meet these criteria for white-tailed deer (Odocoileus

375

Population Ecology Spotlight Surveys for White-Tailed Deer  

E-print Network

ABSTRACT Many monitoring programs for white-tailed deer (Odocoileus virginianus) on both private and public, Odocoileus virginianus, spot- light surveys, variance components, white-tailed deer. One of the primary the white-tailed deer (Odocoileus virginianus). A suite of approaches have been used to look at deer

Ditchkoff, Steve

376

Research Article Spotlight Surveys for White-Tailed Deer  

E-print Network

ABSTRACT Many monitoring programs for white-tailed deer (Odocoileus virginianus) on both private and public, Odocoileus virginianus, spot- light surveys, variance components, white-tailed deer. One of the primary the white-tailed deer (Odocoileus virginianus). A suite of approaches have been used to look at deer

Ditchkoff, Steve

377

Chronic wasting disease in a Wisconsin white-tailed deer farm  

USGS Publications Warehouse

In September 2002, chronic wasting disease (CWD), a prion disorder of captive and wild cervids, was diagnosed in a white-tailed deer (Odocoileus virginianus) from a captive farm in Wisconsin. The facility was subsequently quarantined, and in January 2006 the remaining 76 deer were depopulated. Sixty animals (79%) were found to be positive by immunohistochemical staining for the abnormal prion protein (PrPCWD) in at least one tissue; the prevalence of positive staining was high even in young deer. Although none of the deer displayed clinical signs suggestive of CWD at depopulation, 49 deer had considerable accumulation of the abnormal prion in the medulla at the level of the obex. Extraneural accumulation of the abnormal protein was observed in 59 deer, with accumulation in the retropharyngeal lymph node in 58 of 59 (98%), in the tonsil in 56 of 59 (95%), and in the rectal mucosal lymphoid tissue in 48 of 58 (83%). The retina was positive in 4 deer, all with marked accumulation of prion in the obex. One deer was considered positive for PrPCWD in the brain but not in the extraneural tissue, a novel observation in white-tailed deer. The infection rate in captive deer was 20-fold higher than in wild deer. Although weakly related to infection rates in extraneural tissues, prion genotype was strongly linked to progression of prion accumulation in the obex. Antemortem testing by biopsy of rectoanal mucosal-associated lymphoid tissue (or other peripheral lymphoid tissue) may be a useful adjunct to tonsil biopsy for surveillance in captive herds at risk for CWD infection.

Keane, D. P.; Barr, D. J.; Bochsler, P. N.; Hall, S. M.; Gidlewski, T.; O'Rourke, K. I.; Spraker, T. R.; Samuel, M. D.

2008-01-01

378

20 CFR 410.428 - X-ray, biopsy, and autopsy evidence of pneumoconiosis.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 2010-04-01 false X-ray, biopsy, and autopsy evidence of pneumoconiosis...Pneumoconiosis § 410.428 X-ray, biopsy, and autopsy evidence of pneumoconiosis...existence of pneumoconiosis, or (3) A biopsy (other than a needle biopsy) shows...

2010-04-01

379

Analysis of repeated biopsy results within 1 year after a noncancer diagnosis  

Microsoft Academic Search

Objectives. A prostate biopsy data base derived from patients referred to private practice urologists was analyzed for the cancer diagnosis rates of the “initial” biopsy and the repeated biopsy performed within 1 year for those patients with a noncancer diagnosis.Methods. A retrospective analysis assessed 132,426 prostate biopsies received and processed by a single pathology laboratory between March 1994 and September

Gerard J O’dowd; M. Craig Miller; Roberto Orozco; Robert W Veltri

2000-01-01

380

Advanced breast biopsy instrumentation (ABBI) and management of nonpalpable breast abnormalities: a community hospital experience  

Microsoft Academic Search

A range of diagnostic techniques have been in use for determining the nature of non-palpable mammographic abnormalities over the last decade, these include stereotactic and ultrasound guided cytology, core biopsy and vacuum assisted core biopsy techniques as well as open surgical breast biopsy. Recently, a less invasive alternative has been investigated; the Advanced Breast Biopsy Instrumentation (ABBI) technique (U.S. Surgical

I. A. Jacobs; A. H. Chevinsky; W. Diehl; T. J. Smith

2001-01-01

381

Eimeria spp. (Apicomplexa: Eimeriidae) from black- and white-tailed prairie dogs (Cynomys ludovicianus and Cynomys leucurus) in central and southeast Wyoming.  

PubMed

Feces collected from live-trapped black- (Cynomys ludovicianus) and white-tailed prairie dogs (Cynomys leucurus) from central and southeastern Wyoming were examined to determine the presence and prevalence of eimerian species. Six species (Eimeria adaensis [black-tailed prairie dog prevalence = 33%, white-tailed prairie dog prevalence = 51%], Eimeria beecheyi [8%, 28%], Eimeria callosper-mophili [64%, 71%], Eimeria lateralis [3%, 7%], Eimeria morainensis [19%, 8%], and Eimeria spermophili [2%, 1%]) were identified from both host species. Eimeria pseudospermophili was found infecting only black-tailed (prevalence = 1%) and Eimeria bilamellata only in white-tailed prairie dogs (2%). Reinfections in individual hosts were observed with E. callospermophili and E. adaensis. Comparison of these results with the published literature suggests that the host genera Cynomys and Spermophilus share a common guild of eimerians and that members of this guild have a long evolutionary association with these hosts, or host switching, or both, is common between these groups. PMID:9057719

Seville, R S

1997-02-01

382

Ultrasonographic visualization of the liver in sites recommended for blind percutaneous liver biopsy in horses.  

PubMed

Objective-To ascertain the frequency of ultrasonographic identification of liver at sites recommended for blind percutaneous liver biopsy in middle-aged horses and to determine whether the liver is obscured by other organs or too thin for safe sample collection at recommended locations. Design-Prospective case series. Animals-36 healthy middle-aged (between 6 and 18 years old) Quarter Horses or Quarter Horse crosses. Procedures-Blood samples were collected from each horse and submitted for evaluation of liver function. Horses with any indication of liver dysfunction on serum biochemical analysis were excluded. The region just below a line drawn between the dorsal aspect of the tuber coxae and the point of the elbow joint in the right 11th, 12th, 13th, and 14th intercostal spaces (ICSs) was imaged by ultrasonography for the presence of liver. In each ICS, liver thickness and whether there was partial obstruction in viewing the liver caused by other abdominal or thoracic organs were recorded. Results-39% (14/36) of horses had liver imaged on ultrasonographic examination in all of the 11th to 14th ICSs. None of the 36 horses had liver of adequate thickness (ie, liver thickness ? 3.5 cm) for biopsy in all of the imaged ICSs. For 22 horses in which the liver was not visible on ultrasonographic examination of an ICS, lung was imaged instead in 12 (55%) horses, intestine in 8 (36%), and both intestine and lung in 2 (9%). Conclusions and Clinical Relevance-On the basis of the results of this study, the practice of blind percutaneous liver biopsy in horses is not recommended because of the risk of serious complications. PMID:25285936

Sammons, Sara C; Norman, Tracy E; Chaffin, M Keith; Cohen, Noah D

2014-10-15

383

Availability of radium isotopes and heavy metals from scales and tailings of Polish hard coal mining.  

PubMed

Radium and heavy metal contaminated tailings and scales resulting from Polish hard coal mining were investigated for their mobilisation potential by using leaching methods. The main focus is set on a three-step extraction procedure proposed by BCR (Bureau Communautaire de Référence, now Standards Measurements and Testing Programme) of the European Union, which was used for investigating the availability of radium isotopes. In addition, the results of a Polish extraction procedure for the heavy metals' water solubility are presented for rough comparison. After a special treatment, the BCR-reagents were measured by gamma-spectrometry to define their radium activity concentrations; the heavy metal content in the water soluble fractions was determined by ICP-AES. The samples were collected at two different sites influenced by the discharge of pit water from hard coal mining. The tailings were taken from a former tailing pond, which now is no longer in use, but the settled material is still present. At another abandoned and meanwhile flooded tailing pond, the scales were scraped from the inside of a discharge tube. The results obtained show that there is different leaching behaviour between the radium isotopes. The tailings being characterised by surface adsorbed radium provide up to 25% of the initial (226)Ra content, (228)Ra is altogether leached up to 15%. The scales comprise stable radiobaryte (Ba[Ra]SO(4)) and can be considered as being unable to provide radium isotopes, since no trace of radium dissolution was observed. The leaching behaviour of heavy metals is similar to that of radium. Mn, Ni and Zn are dissolved by water from the tailings; the scales do not provide any. PMID:17350147

Leopold, Karsten; Michalik, Boguslaw; Wiegand, Jens

2007-01-01

384

Prospective study of sentinel lymph node biopsy for conjunctival melanoma  

PubMed Central

Background To report our experience with sentinel lymph node biopsy for staging patients with conjunctival melanoma. Methods A prospective review of patients with conjunctival melanoma who underwent sentinel lymph node biopsy at St Bartholomew's Hospital from May 2008 to May 2012. The selection criterion for sentinel node biopsy depended on the tumour thickness (?2?mm) and location of the conjunctival melanoma. The main outcome measures were the incidence of sentinel lymph node positivity and the procedure-related complications. Results In 4?years, 26 out of 70 patients met the selection criteria for sentinel lymph node biopsy. 4 patients declined and 22 patients consented for the procedure. Technetium-99m failed to identify a sentinel lymph node in four of the 22 patients (18%). Of the remaining 18 patients, two were found to have subclinical micrometastasis in regional lymph nodes. Median follow-up was 20?months (range 6–36?months). No false-negative events were observed. Complications of the procedure included transient blue staining of the epibulbar surface in five patients and transient facial nerve palsy in one patient. Conclusions Sentinel lymph node biopsy is a safe procedure with minimal complications. It should be considered for the staging of conjunctival melanomas, especially melanomas in non-limbal location or conjunctival melanomas ?2?mm thick. PMID:24064944

Cohen, Victoria M L; Tsimpida, Maria; Hungerford, John L; Jan, Hikmat; Cerio, Rino; Moir, Graeme

2013-01-01

385

Peripheral autonomic neuropathy: diagnostic contribution of skin biopsy.  

PubMed

Skin biopsy has gained widespread use for the diagnosis of somatic small-fiber neuropathy, but it also provides information on sympathetic fiber morphology. We aimed to ascertain the diagnostic accuracy of skin biopsy in disclosing sympathetic nerve abnormalities in patients with autonomic neuropathy. Peripheral nerve fiber autonomic involvement was confirmed by routine autonomic laboratory test abnormalities. Punch skin biopsies were taken from the thigh and lower leg of 28 patients with various types of autonomic neuropathy for quantitative evaluation of skin autonomic innervation. Results were compared with scores obtained from 32 age-matched healthy controls and 25 patients with somatic neuropathy. The autonomic cutoff score was calculated using the receiver operating characteristic curve analysis. Skin biopsy disclosed a significant autonomic innervation decrease in autonomic neuropathy patients versus controls and somatic neuropathy patients. Autonomic innervation density was abnormal in 96% of patients in the lower leg and in 79% of patients in the thigh. The abnormal findings disclosed by routine autonomic tests ranged from 48% to 82%. These data indicate the high sensitivity and specificity of skin biopsy in detecting sympathetic abnormalities; this method should be useful for the diagnosis of autonomic neuropathy, together with currently available routine autonomic testing. PMID:23037327

Donadio, Vincenzo; Incensi, Alex; Giannoccaro, Maria Pia; Cortelli, Pietro; Di Stasi, Vitantonio; Pizza, Fabio; Jaber, Masen Abdel; Baruzzi, Agostino; Liguori, Rocco

2012-11-01

386

CT Guided Bone Biopsy Using a Battery Powered Intraosseous Device  

SciTech Connect

Purpose: To evaluate the feasibility of a battery powered intraosseous device to perform CT-fluoroscopy guided bone biopsy. Methods: Retrospective analysis of 12 patients in whom bone specimen were acquired from different locations under CT-fluoroscopy guidance using the OnControl bone marrow biopsy system (OBM, Vidacare, Shavano Park, TX, USA). Data of the 12 were compared to a historic cohort in whom the specimen were acquired using the classic Jamshidi Needle, as reference needle using manual force for biopsy. Results: Technical success was reached in 11 of 12 cases, indicated by central localisation of the needle within the target lesion. All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 {+-} 6 to 6 {+-} 4 min (P = 0.0001). Due to the shortened intervention time the radiation dose (CTDI) during CT-fluoroscopy was lowered significantly from 169 {+-} 87 to 111 {+-} 54 mGy Multiplication-Sign cm (P = 0.0001). Interventional radiologists were confident with the performance of the needle especially when using in sclerotic or osteoblastic lesions. Conclusion: The OBM is an attractive support for CT-fluoroscopy guided bone biopsy which is safe tool and compared to the classical approach using the Jamshidi needle leading to significantly reduced intervention time and radiation exposure.

Schnapauff, Dirk, E-mail: dirk.schnapauff@charite.de; Marnitz, Tim, E-mail: tim.marnitz@charite.de; Freyhardt, Patrick, E-mail: Patrick.freyhardt@charite.de; Collettini, Federico, E-mail: Federico.collettini@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany)] [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany); Hartwig, Kerstin, E-mail: kerstin.hartwig@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Haematology and Oncology (Germany)] [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Haematology and Oncology (Germany); Joehrens, Korinna, E-mail: korinna.joehrens@charite.de [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Pathology (Germany)] [Charite Universitaetsmedizin Berlin, Campus Charite Mitte, Department of Pathology (Germany); Hamm, Bernd, E-mail: bernd.hamm@charite.de; Kroencke, Thomas, E-mail: thomas.kroencke@charite.de; Gebauer, Bernhard, E-mail: Bernhard.gebauer@charite.de [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany)] [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Department of Radiology (Germany)

2013-10-15

387

Improved radon-flux-measurement system for uranium-tailings pile measurement  

SciTech Connect

The Pacific Northwest Laboratory (PNL) is developing cover technology for uranium mill tailings that will inhibit the diffusion of radon to the atmosphere. As part of this cover program, an improved radon flux measurement system has been developed. The radon measurement system is a recirculating, pressure-balanced, flow-through system that uses activated carbon at ambient temperatures to collect the radon. With the system, an area of 0.93 m/sup 2/ is sampled for periods ranging from 1 to 12 h. The activated carbon is removed from the radon trap and the collected radon is determined by counting the /sup 214/Bi daughter product. Development of the system included studies to determine the efficiency of activated carbon, relative calibration measurements and field measurements made during 1980 at the inactive tailings pile in Grand Junction, Colorado. Results of these studies are presented.

Freeman, H.D.

1981-10-01

388

The tail of the Ordovician fish Sacabambaspis.  

PubMed

The tail of the earliest known articulated fully skeletonized vertebrate, the arandaspid Sacabambaspis from the Ordovician of Bolivia, is redescribed on the basis of further preparation of the only specimen in which it is most extensively preserved. The first, but soon discarded, reconstruction, which assumed the presence of a long horizontal notochordal lobe separating equal sized dorsal and ventral fin webs, appears to have considerable merit. Although the ventral web is significantly smaller than the dorsal one, the presence of a very long notochordal lobe bearing a small terminal web is confirmed. The discrepancy in the size of the ventral and dorsal webs rather suggests that the tail was hypocercal, a condition that would better accord with the caudal morphology of the living agnathans and the other jawless stem gnathostomes. PMID:17443969

Pradel, Alan; Sansom, Ivan J; Gagnier, Pierre-Yves; Cespedes, Ricardo; Janvier, Philippe

2007-02-22

389

Long-tail liability law reform.  

PubMed

There is a need for the law to evolve so that corporations are obliged to make proper provision for liabilities to unascertained future creditors. However, implementation of long-tail liabilities is far from straightforward and has many repercussions for both corporations and personal injury law. In October 2005 the Parliamentary Secretary to the Treasurer requested the Corporations and Markets Advisory Committee to consider a "referred proposal" designed to achieve comprehensive and principled law reform. Analysis of the referred proposal reveals many shortcomings, a number of which have been addressed by the Committee in its June 2007 Discussion Paper, Long-Tail Liabilities: The Treatment of Unascertained Future Personal Injury Claims. This editorial urges further and reflective analysis of the referred proposal and of the Committee's tentative suggestions in order to achieve a balance among the entitlements of unascertained future creditors, other known creditors, shareholders, corporations' financial viability, and the conceptual integrity of corporations law. PMID:18035836

Freckelton, Ian

2007-10-01

390

Age-Specific Prostate Specific Antigen Cutoffs for Guiding Biopsy Decision in Chinese Population  

PubMed Central

Background Age-specific prostate specific antigen (PSA) cutoffs for prostate biopsy have been widely used in the USA and European countries. However, the application of age-specific PSA remains poorly understood in China. Methods Between 2003 and 2012, 1,848 men over the age of 40, underwent prostate biopsy for prostate cancer (PCa) at Huashan Hospital, Shanghai, China. Clinical information and blood samples were collected prior to biopsy for each patient. Men were divided into three age groups (?60, 61 to 80, and >80) for analyses. Digital rectal examination (DRE), transrectal ultrasound (prostate volume and nodule), total PSA (tPSA), and free PSA (fPSA) were also included in the analyses. Logistic regression was used to build the multi-variate model. Results Serum tPSA levels were age-dependent (P?=?0.008), while %fPSA (P?=?0.051) and PSAD (P?=?0.284) were age-independent. At a specificity of 80%, the sensitivities for predicting PCa were 83%, 71% and 68% with tPSA cutoff values of 19.0 ng/mL (age?60),21.0 ng/mL (age 61–80), and 23.0 ng/mL (age?81). Also, sensitivities at the same tPSA levels were able to reach relatively high levels (70%–88%) for predicting high-grade PCa. Area (AUC) under the receive operating curves (ROCs) of tPSA, %fPSA, PSAD and multi-variate model were different in age groups. When predicting PCa, the AUC of tPSA, %fPSA, PSAD and multi-variate model were 0.90, 0.57, 0.93 and 0.87 respectively in men ?60 yr; 0.82, 0.70, 0.88 and 0.86 respectively in men 61–80 yr; 0.79, 0.78, 0.87 and 0.88 respectively in men>80 yr. When predicting Gleason Score ?7 or 8 PCa, there were no significant differences between AUCs of each variable. Conclusion Age-specific PSA cutoff values for prostate biopsy should be considered in the Chinese population. Indications for prostate biopsies (tPSA, %fPSA and PSAD) should be considered based on age in the Chinese population. PMID:23825670

Xu, Jianfeng; Jiang, Haowen; Ding, Qiang

2013-01-01

391

Antislavery Collection  

NSDL National Science Digital Library

The digital collections at the University of Massachusetts at Amherst are top-flight and this collection continues that grand tradition. The Antislavery Collection contains several hundred pamphlets and books pertaining to slavery and antislavery in New England from 1725-1911. These items include speeches, sermons, proceedings, and other publications from organizations such as the American Anti-Slavery Society, the American Colonization Society, and a small number of pro-slavery tracts. Visitors can browse the selected titles alphabetically or perform a more detailed search across all of the items. Several documents should not be missed, including speeches by Horace Mann and Ezra Gannett's "Relation of the North to Slavery" delivered in Boston in 1854.

392

Carnival Collection  

NSDL National Science Digital Library

"Come to the carnival" is a common refrain in New Orleans during the month of February, and this intoxicating collection from Tulane University pays homage to this wonderful cultural tradition. The collection includes over 1,500 float designs from the "Golden Age" of carnival by notable designers such as Jennie Wilde, B.A. Wikstrom, and Charles Briton. Support for the project comes from the late Charles L. "Pie" Dufour who left funds to continue the preservation of these rare and unique ephemeral materials. Visitors can browse at their leisure, and they may wish to start with fanciful designs like the 1870 "Twelfth Night Revelers" float or the 1891 "Atlanteans" design. Also, visitors can select the work of a particular float designer or krewe of note. Also, visitors can search the entire collection by keyword.

2012-02-24

393

Genthe Collection  

NSDL National Science Digital Library

Arnold Genthe had an urbane German upbringing in Berlin, Frankfurt, Korbach, and Hamburg. Born in 1869, he wanted to become an artist, but a family relation discouraged him. Fortunately, he ended up moving to America in 1895 to become a tutor, and while there in began to experiment with photography. Over the following five decades, he would go on to document the aftermath of the San Francisco Earthquake and take photos of President Woodrow Wilson, Arturo Toscanini, and many others. Eventually his tremendous collection of work found its way to the Library of Congress, and here visitors can traipse through over 16,000 of his images. Along with a brief overview of the collection, visitors should also read the informative essay here titled "The Negative and the Print: Genthe's Photographic Techniques". It is easy enough to search the collection, although visitors can also browse the selections by name, subject, or format.

Genthe, Arnold, 1869-1942

394

Prone view ultrasonography for pancreatic tail neoplasms.  

PubMed

Ultrasonography was performed in the prone and supine positions in six patients with neoplasms in the tail of the pancreas. The masses were either not apparent (three cases) or less well visualized on the supine scans. The value and indications of the prone position in the ultrasonic evaluation of masses in this portion of the pancreas are documented. Prone scanning is particularly useful when malignant ascites interferes with pancreatic visualization in the supine position. PMID:98000

Goldstein, H M; Katragadda, C S

1978-08-01

395

RED-TAILED HAWK (Buteo jamaicensis)  

Microsoft Academic Search

Daily fluctuations in resting heart rate (HR) were studied in a captive ? Red-tailed Hawk (Buteojamaicensis) using radiotelemetry. HR's were recorded hourly during 10 consecutive days while the hawk was housed in an outdoor pen. Daytime HR's averaged 202 beats\\/min and were significantly higher than the average nocturnal HR of 134 beats\\/min (P < 0.001). Maximum HR's ( >200 beats\\/min)

WILLIAM A. DEGRAw; N. C. CLAMPITT

396

Missile rolling tail brake torque system  

NASA Astrophysics Data System (ADS)

Apparatus for simulating varying levels of friction in the bearings of a free rolling tail afterbody on a canard-controlled missile to determine friction effects on aerodynamic control characteristics is described. A ring located between the missile body and the afterbody is utilized in a servo system to create varying levels of friction between the missile body and the afterbody to simulate bearing friction.

Davis, W. T.

1984-01-01

397

A Randomized Trial of Sheathed vs. Standard Forceps for Obtaining Uncontaminated Biopsy Specimens of Microbiota from the Terminal Ileum  

PubMed Central

Background The study of intestinal microbiota has been revolutionized by the use of molecular methods, including terminal restriction fragment length polymorphism (T-RFLP) analysis. A number of microbiota studies of Crohn’s disease patients have examined samples from stool or from the neoterminal ileum with a standard biopsy forceps, which could be contaminated by colonic bacteria when the forceps passes through the colonoscope channel. Objective To determine whether sheathed biopsy forceps are able to obtain terminal ileal microbiota samples with less colonic bacterial contamination compared to unsheathed (standard) biopsy forceps. Design Prospective randomized single center-study. Patients and Methods We obtained four (paired) biopsy specimens from adjacent locations in the terminal ileum using the sheathed and standard forceps of 27 consecutive subjects undergoing colonoscopy and characterized the microbiota using T-RFLP. We calculated the Bray Curtis similarity index (BCI) between samples (sheathed vs. unsheathed forceps) within patients and tested for significant differences across all patients. Results There was not a significant difference in the microbial diversity of samples obtained using sheathed vs. unsheathed forceps. The difference in microbial diversity between patients was much greater than the variability within patients by proximal vs. distal site or by forceps type. Limitations T-RFLP is based on PCR amplification, so it is not always sensitive to rare bacterial species. Conclusion Standard unsheathed forceps appear to be sufficient for microbiota sample collection from the terminal ileum. PMID:21317176

Dave, Maneesh; Johnson, Laura A.; Walk, Seth; Young, Vincent B.; Stidham, Ryan W.; Chaudhary, Meghana N.; FunNell, Jessica; Higgins, Peter D.R.

2014-01-01

398

The Sulften System - Advanced tail gas treating  

SciTech Connect

The Sulften System is an advanced tail gas treating process that maximizes sulfur recovery efficiency by the combination of new and unique reaction and absorption technologies. The principal feature of the Sulften System is its ability to produce a sulfur plant vent gas effluent with a hydrogen sulfide (H/sub 2/S) concentration of less than 10 ppm on a dry and oxygen-free basis. Conventional tail gas treating processes typically produce a vent stream containing 100 to 250 ppm H/sub 2/S. The primary goal of the Sulften System is to meet the U.S. Environmental Protection Agency New Source Performance Standards (NSPS) requirement that direct discharge of H/sub 2/S be limited to concentrations of less than 10 ppm. The resultant benefits of this technological breakthrough are a reduction in total sulfur discharge and incinerator thermal pollution, virtual elimination of incinerator fuel cost, reduction in tail gas treating unit (TGTU) operating cost, and potential reduction in incinerator capital investment for a grassroots unit, while providing the operating ease characteristic of amine-based TGTU processes.

Kroop, L.; Sigmund, P.W.; Taggart, G.W.

1985-01-01

399

On the variability of He+ suprathermal tails  

NASA Astrophysics Data System (ADS)

Interstellar neutral helium penetrates to well within 1 AU where it is ionized predominantly by UV from the Sun. These freshly created He+ pickup ions (PUI) are convected outward with the solar wind and subject to acceleration processes, for example in compression regions, corotating interaction regions, or CME-driven interplanetary shocks. These acceleration processes result in the formation of suprathermal tails in the PUI velocity distribution. The PLASTIC instruments on the STEREO spacecraft cover for pickup He the energy range of ~1-20 keV/nuc. They allow the determination of PUI velocity distribution functions from the source distribution to suprathermal energies. In this paper we study the suprathermal tails of He pickup ions during the period January to December 2008 that featured many corotating interaction regions. The PLASTIC observations for the He+ suprathermal tail show a large variability of the spectral index ? of the distribution function f(w)~w?, with w = V/Vsw, where V and Vsw are the particle velocity and the solar wind velocity, respectively. Incorporating a transformation from the spacecraft frame to the solar wind frame, the spectral index at velocities 1.5 <= w <= 5 (in the solar wind frame) ranges from ? ~ -5.7 at a forward shock to ? = -9 in the slow solar wind.

Popecki, M. A.; Klecker, B.; Simunac, K. D. C.; Galvin, A. B.; Kucharek, H.

2013-06-01

400

Sequential muscle biopsy changes in a case of congenital myopathy.  

SciTech Connect

Muscle biopsies at age 7 months in a set of dizygotic male twins born floppy showed typical features of congenital fiber-type disproportion (CFTD). One of the twins died at age 1 year due to respiratory complications. The second one subsequently developed facial diplegia and external ophthalmoplegia. He never walked, remained wheelchair bound, and required continuous ventilatory support. He underwent repeat biopsies at ages 2 and 4, which showed many atrophic type 1 muscle fibers containing central nuclei and severe type 2 fiber deficiency compatible with centronuclear myopathy (CNM). Two-dimensional gel electrophoresis of muscle showed decreases of type II myosin light chains 2 and 3, suggestive of histochemical type I fiber deficiency. The progressive nature of morphological changes in one of our patients cannot be explained by maturational arrest. Repeat biopsies in cases of CFTD with rapid clinical deterioration may very well show CNM.

Danon, M. J.; Giometti, C. S.; Manaligod, J. R.; Swisher, C.; Center for Mechanistic Biology and Biotechnology; New York Medical Coll.; Univ. of Illinois at Chicago; Children's Memorial Hospital

1997-05-01

401

Application of Sentinel Lymph Node Biopsy in Cutaneous Basosquamous Carcinoma  

PubMed Central

Basosquamous carcinoma of the skin is a relatively rare cutaneous neoplasm that has significant metastatic potential and a metastatic rate greater than that of basal cell and squamous cell carcinoma. We describe the use of lymphatic mapping and sentinel lymph node biopsy in a 63-year-old man after identification of basosquamous carcinoma. Sentinel lymph node biopsy, which is a standard tool to detect regional lymphatic metastasis in cutaneous melanoma, has been rarely employed to detect lymphatic metastasis of basosquamous carcinoma. The approach was successful in detecting a regional lymphatic metastasis of two nodal basins with minor morbidity. Sentinel lymph node biopsy may be useful for certain high-risk lesions of basosquamous carcinoma. PMID:22028558

Kovacevic, Predrag; Visnjic, Milan; Jankovic, Dimitrije; Binic, Ivana; Jankovic, Aleksandar; Ilic, Ivan

2011-01-01

402

Uses of Skin Biopsy for Sensory and Autonomic Nerve Assessment  

PubMed Central

Skin biopsy is a valuable diagnostic tool for small-fiber-predominant neuropathy by the quantification of intra-epidermal nerve fiber density (IENFD). It has the unique advantage of being a minimally invasive procedure with the potential for longitudinal evaluation of both sensory and autonomic fibers. Unmyelinated small fibers are not otherwise quantified objectively with such a level of sensitivity as has been reported with IENFD. Recent advances include an expansion of the skin punch biopsy technique to evaluate larger myelinated fibers and mechanoreceptors, and recent work has also focused on additional methods of quantifying dermal fibers and densely innervated autonomic structures. This review discusses current work using skin biopsy for the pathologic analysis of peripheral nerve fibers in neuropathy of various causes as well as its use in clinical trials. PMID:23250768

Myers, M. Iliza; Peltier, Amanda C.

2013-01-01

403

Evaluating dermal myelinated nerve fibers in skin biopsy  

PubMed Central

Although there has been extensive research on small, unmyelinated fibers in the skin, little research has investigated dermal myelinated fibers in comparison. Glabrous, non-hairy skin contains mechanoreceptors that afford a vantage point for observation of myelinated fibers that have previously been seen only with invasively obtained nerve biopsies. This review discusses current morphometric and molecular expression data of normative and pathogenic glabrous skin obtained by various processing and analysis methods for cutaneous myelinated fibers. Recent publications have shed light on the role of glabrous skin biopsy in identifying signs of peripheral neuropathy and as a potential biomarker of distal myelin and mechanoreceptor integrity. The clinical relevance of a better understanding of the role of dermal myelinated nerve terminations in peripheral neuropathy will be addressed in light of recent publications in the growing field of skin biopsy. PMID:23192899

Myers, M. Iliza; Peltier, Amanda C.; Li, Jun

2012-01-01

404

Performing bone marrow aspiration and biopsy in children: Recommended guidelines  

PubMed Central

Bone marrow aspiration (BMA) and bone marrow trephine biopsy are important procedures for the diagnosis of hematological malignancies and nonmalignant diseases in children. During BMA, bone marrow particles are obtained for analysis including microscopic morphologic evaluations and differential counts. During a trephine biopsy, a core of bone marrow is obtained and processed for the evaluation of marrow cellularity and to rule out marrow involvement by solid tumours, lymphomas or other processes. These invasive procedures should only be performed by a trained individual following a standard operating technique. There are no clear published guidelines in the paediatric literature. Hence, the purpose of the present article is to provide guidelines for the performance of BMAs and bone marrow trephine biopsies in children that will be useful for both general paediatricians and paediatric hematologists and oncologists. PMID:19436420

Abla, Oussama; Friedman, Jeremy; Doyle, John

2008-01-01

405

The microtrephine. A new diagnostic tool for obtaining corneal biopsies.  

PubMed

We have developed a new tool for obtaining biopsies of the cornea in a manner which is less traumatic than former biopsy techniques. The new instrument consists of a drill with an aperture of 160 microns which functions as a trephine and is powered at 30,000 rpm. The instrument contains a 120 microns mandrel to remove the samples. In order to monitor electrolyte contents in alkali burnt corneas, 32 rabbit eyes underwent an alkali burn of one cornea (1 n NaOH for 30 sec) followed by a sequence of microtrephinations at different times. A total of 81 microtrephinations were performed. Fifty samples were obtained. One corneal perforation occurred. Forty-four puncture sites were examined by means of histology. Forty-eight biopsies were examined in a scanning electron microscope and identified as punctures of corneal tissue by way of an energy dispersive X-ray analysis. Human corneas had been punctured with this device. PMID:7976274

Schrage, N F; Lorenz, U; von Fischern, T; Reim, M

1994-06-01

406

Specimens from Biopsies of Colorectal Polyps Often Harbor Additional Diagnoses  

PubMed Central

Objectives. The utility of examining specimens from colorectal biopsies of polyps for nonneoplastic diseases is currently unknown. Our objectives were to characterize such additional diagnoses that could be rendered. Methods. We retrospectively and prospectively reviewed specimens from endoscopic biopsies of colorectal polyps obtained during routine screening or surveillance. Results. 17 of 168 specimens (10.1%) contained additional diagnoses, including schistosomiasis, eosinophilic colitis, intestinal spirochetosis, melanosis coli, and other entities. These findings were easily overlooked because they often affected mucosa that was spared by the polyps or were often evident only at high magnification. Schistosomiasis, eosinophilic colitis, and intestinal spirochetosis were clinically occult. Conclusions. Specimens from biopsies of colorectal polyps often harbor other diagnoses, in addition to polyps, and can be simultaneously screened for polyps and examined for nonneoplastic diseases. Detection of other diagnoses in addition to polyps requires awareness, examination at high magnification, and examination of areas spared by the polyps. PMID:24455417

2013-01-01

407

Osteolytic Paget's disease. Recognition and risks of biopsy.  

PubMed

The cases of five patients with the predominantly osteolytic form of Paget's disease affecting weight-bearing long bones are described. The diagnosis was not recognized initially in three. In two of them a biopsy was performed, and one subsequently had a fracture through the biopsy site more than a year later. In all five, calcitonin treatment was effective in restoring the bone architecture toward normal as determined radiographically. Relapse occurred in two patients shortly after the cessation of calcitonin treatment and in a third despite continued treatment. The flame-shaped resorption from of the osteolytic component of Paget's disease has a pathognomonic appearance radiographically. Radionuclide bone-scanning can help in establishing the diagnosis. Diagnostic biopsy of such an area, particularly in a weight-bearing long bone, is unnecessary and should be avoided because of the increased risk of fracture. PMID:3941112

Eisman, J A; Martin, T J

1986-01-01

408

Miliary Tuberculosis Following Transrectal Ultrasonography (TRUS)-Guided Prostate Biopsy  

PubMed Central

Miliary tuberculosis (TB) after transrectal ultrasonography (TRUS)-guided prostate biopsy is an extremely rare complication. A 75-year-old patient who presented with high fever and cough following TRUS-guided prostate biopsy for his high serum prostate-specific antigen (PSA) level (13.104 ng/ml) was diagnosed with miliary TB after clinical, laboratory, and radiological assessments. Histopathological examination of the prostate revealed TB with acid-fast bacilli. He was treated with chemotherapy for 9 months. The patient is now symptom-free, and his post-treatment PSA level was 5.023 ng/ml. This case is reported to acknowledge the possibility that miliary TB can occur as a complication of prostate biopsy if the patient suffers from prostate TB. PMID:21755022

Sano, Taichi; Takimoto, Keita

2011-01-01

409

Cerebral air embolism following transbronchial lung biopsy during flexible bronchoscopy  

PubMed Central

During a diagnostic flexible bronchoscopy an 84 year old patient suffered a sudden reduction in conscious level following a transbronchial lung biopsy. A subsequent computed tomography brain scan confirmed cerebral air emboli. The patient survived following a period of supportive treatment in the critical care unit. Transbronchial lung biopsy may cause disruption of vessels walls within the lung parenchyma. Increased airway pressure, caused by the patient exhaling against a bronchoscope wedged within a segmental bronchi, may subsequently force air bubbles through the vessel wall defects. This may explain the occurrence of air emboli. This is a rare report of air embolism complicating transbronchial lung biopsy and all bronchoscopists should aware of this potentially fatal complication.

Evison, Matthew; Crosbie, Philip A.J.; Bright-Thomas, Rowland; Alaloul, Mohamed; Booton, Richard

2014-01-01

410

COLUMBIAN BLACK-TAILED DEER (ODOCOILEUS HEMIONUS COLUMBIANUS) AS HOSTS FOR BORRELIA SPP. IN NORTHERN CALIFORNIA  

Microsoft Academic Search

The prevalence of infection of Columbian black-tailed deer (Odocoileus hemionus columbianus) with Borrelia spp. was evaluated in an area of northwestern California (USA) where Lyme disease is endemic and the relapsing-fever group spirochete Borrelia coriaceae is enzootic, and in a far-removed comparison area having a disparate climate and lower density of vector ticks. Blood samples collected from both deer herds

Jeomhee Mun; John M. Parker; Marshall White

2005-01-01

411

CHANGES IN THE DISTRIBUTION AND ABUNDANCE OF COLUMBIAN SHARP-TAILED GROUSE IN WASHINGTON  

Microsoft Academic Search

ABSTRACT Columbian sharp-tailed grouse (Tympanuchus phasianellus columbianus) were historically found in shrub steppe, meadow steppe, steppe, and deciduous shrub communities throughout much of eastern Washington. The current range, consisting of8 relatively small, isolated, populations, is less than 3% of historic range. Information collected since 1954 indicates 58% of 107 known,lek complexes,are currently vacant. Many of the vacant lek complexes,(53%) are

Michael A. Schroeder; W. Hays; A. Murphy; D. John Pierce

412

Volatile compounds from interdigital gland of male white-tailed deer ( Odocoileus virginianus )  

Microsoft Academic Search

Interdigital secretions were collected from eight male white-tailed deer of various ages. Analysis of volatiles was performed by gas chromatography-mass spectrometry with a modified headspace technique. Forty-six volatile compounds were found including alkanes, arenes, aldehydes, ketones, aliphatic acids, esters, pyrroles, furans, and sulfur compounds. Eleven occurred in higher concentrations (P0.10) in dominant (3.5-year-old) than in subordinate (1.5-year-old) animals. Dominant males

J. W. Gassett; D. P. Wiesler; A. G. Baker; D. A. Osborn; K. V. Miller; R. L. Marchinton; M. Novotny

1996-01-01

413

Environmental assessment of ground-water compliance activities at the Uranium Mill Tailings Site, Spook, Wyoming  

SciTech Connect

This report assesses the environmental impacts of the Uranium Mill Tailings Site at Spook, Wyoming on ground water. DOE previously characterized the site and monitoring data were collected during the surface remediation. The ground water compliance strategy is to perform no further remediation at the site since the ground water in the aquifer is neither a current nor potential source of drinking water. Under the no-action alternative, certain regulatory requirements would not be met.

NONE

1997-02-01

414

Asphalt emulsion sealing of uranium mill tailings. 1979 annual report  

SciTech Connect

Uranium mill tailings are a source of low-level radiation and radioactive materials that may be released into the environment. Stabilization or disposal of these tailings in a safe and environmentally sound way is necessary to minimize radon exhalation and other radioactive releases. One of the most promising concepts for stabilizing uranium tailings is being investigated at the Pacific Northwest Laboratory: the use of asphalt emulsion to contain radon and other potentially hazardous materials in uranium tailings. Results of these studies indicate that radon flux from uranium tailings can be reduced by greater than 99% by covering the tailings with an asphalt emulsion that is poured on or sprayed on (3.0 to 7.0 mm thick), or mixed with some of the tailings and compacted to form an admixture seal (2.5 to 15.2 cm) containing 18 wt % residual asphalt.

Hartley, J.N.; Koehmstedt, P.L.; Esterl, D.J.; Freeman, H.D.

1980-06-01

415

Febrile Urinary Tract Infection After Prostate Biopsy and Quinolone Resistance  

PubMed Central

Purpose Complications after prostate biopsy have increased and various causes have been reported. Growing evidence of increasing quinolone resistance is of particular concern. In the current retrospective study, we evaluated the incidence of infectious complications after prostate biopsy and identified the risk factors. Materials and Methods The study population included 1,195 patients who underwent a prostate biopsy between January 2007 and December 2012 at Chung-Ang University Hospital. Cases of febrile UTI that occurred within 7 days were investigated. Clinical information included age, prostate-specific antigen, prostate volume, hypertension, diabetes, body mass index, and biopsy done in the quinolone-resistance era. Patients received quinolone (250 mg intravenously) before and after the procedure, and quinolone (250 mg) was orally administered twice daily for 3 days. We used univariate and multivariate analysis to investigate the predictive factors for febrile UTI. Results Febrile UTI developed in 39 cases (3.1%). Core numbers increased from 2007 (8 cores) to 2012 (12 cores) and quinolone-resistant bacteria began to appear in 2010 (quinolone-resistance era). In the univariate analysis, core number?12 (p=0.024), body mass index (BMI)>25 kg/m2 (p=0.004), and biopsy done in the quinolone-resistance era (p=0.014) were significant factors. However, in the multivariate analysis adjusted for core number, the results were not significant, with the exception of BMI>25 kg/m2 (p=0.011) and biopsy during the quinolone-resistance era (p=0.035), which were significantly associated with febrile UTI. Conclusions Quinolone resistance is the main cause of postbiopsy infections in our center. We suggest that further evaluation is required to validate similar trends. Novel strategies to find alternative prophylactic agents are also necessary.

Choi, Joong Won; Chang, In Ho; Kim, Kyung Do; Moon, Young Tae; Myung, Soon Chul; Kim, Jin Wook; Kim, Min Su; Kwon, Jong Kyou

2014-01-01

416

Three-dimensional ultrasound-guided breast biopsy system  

NASA Astrophysics Data System (ADS)

We introduce a mechanically constrained, 3D ultrasound- guided core-needle breast biopsy device. With modest breast compression, 3D ultrasound scans localize suspicious masses. A biopsy needle is mechanically guided into position for firing into the sampling region. Th needle is parallel to the transducer, allowing real-time guidance during needle insertion. Lesion sampling is verified by another ultrasound image after firing. Two procedures quantified targeting accuracy of this apparatus. First, we biopsied eleven breast phantoms containing 123 embedded, cylindrical lesions constructed from PVA-C (poly(vinyl alcohol) cryogel) with diameters ranging from 1.6 to 15.9mm. Identification of the colored lesion in the biopsy sample and analysis of the post-biopsy US images provided a model for the success rates. Using this, we predict that our apparatus will require six passes to biopsy a 3.0 mm lesion with 99% confidence. For the second experiment, agar phantoms were embedded with four rows of 0.8mm stainless steel beads. A 14-gauge needle was inserted to each bead position seen in a 3D ultrasound scan and the tip position was compared to the pre-insertion bead position. The inter-observer standard errors of measurement were less than 0.15 and 0.28mm for the bead and needle tip positions, respectively. The off-axis 3D 95% confidence intervals were determined to have widths between 0.43 and 1.71mm, depending on direction and bead position.

Smith, Wendy L.; Surry, Kathleen J. M.; Campbell, Laura; Mills, Greg; Downey, Donal B.; Fenster, Aaron

2001-05-01

417

Trans-rectal interventional MRI: initial prostate biopsy experience  

NASA Astrophysics Data System (ADS)

Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) of the prostate gland when evaluated along with T2-weighted images, diffusion-weighted images (DWI) and their corresponding apparent diffusion coefficient (ADC) maps can yield valuable information in patients with rising or elevated serum prostate-specific antigen (PSA) levels1. In some cases, patients present with multiple negative trans-rectal ultrasound (TRUS) biopsies, often placing the patient into a cycle of active surveillance. Recently, more patients are undergoing TRIM for targeted biopsy of suspicious findings with a cancer yield of ~59% compared to 15% for second TRUS biopsy2 to solve this diagnostic dilemma and plan treatment. Patients were imaged in two separate sessions on a 1.5T magnet using a cardiac phased array parallel imaging coil. Automated CAD software was used to identify areas of wash-out. If a suspicious finding was identified on all sequences it was followed by a second imaging session. Under MRI-guidance, cores were acquired from each target region3. In one case the microscopic diagnosis was prostatic intraepithelial neoplasia (PIN), in the other it was invasive adenocarcinoma. Patient 1 had two negative TRUS biopsies and a PSA level of 9ng/mL. Patient 2 had a PSA of 7.2ng/mL. He underwent TRUS biopsy which was negative for malignancy. He was able to go on to treatment for his prostate carcinoma (PCa)4. MRI may have an important role in a subset of patients with multiple negative TRUS biopsies and elevated or rising PSA.

Greenwood, Bernadette M.; Behluli, Meliha R.; Feller, John F.; May, Stuart T.; Princenthal, Robert; Winkel, Alex; Kaminsky, David B.

2010-02-01

418

Active Vertical Tail Buffeting Alleviation on a Twin-Tail Fighter Configuration in a Wind Tunnel  

NASA Technical Reports Server (NTRS)

A 1/6-scale F-18 wind-tunnel model was tested in the Transonic Dynamics Tunnel at the NASA Langley Research Center as part of the Actively Controlled Response Of Buffet-Affected Tails (ACROBAT) program to assess the use of active controls in reducing vertical tail buffeting. The starboard vertical tail was equipped with an active rudder and other aerodynamic devices, and the port vertical tail was equipped with piezoelectric actuators. The tunnel conditions were atmospheric air at a dynamic pressure of 14 psf. By using single-input-single-output control laws at gains well below the physical limits of the control effectors, the power spectral density of the root strains at the frequency of the first bending mode of the vertical tail was reduced by as much as 60 percent up to angles of attack of 37 degrees. Root mean square (RMS) values of root strain were reduced by as much as 19 percent. Stability margins indicate that a constant gain setting in the control law may be used throughout the range of angle of attack tested.

Moses, Robert W.

1997-01-01

419

Collecting Artifacts  

ERIC Educational Resources Information Center

Fresh out of college, the author had only a handful of items worthy of displaying, which included some fossils she had collected in her paleontology class. She had binders filled with great science information, but kids want to see "real" science, not paper science. Then it came to her: she could fill the shelves with science artifacts with the…

Coffey, Natalie

2004-01-01

420

Wastewater Collection.  

ERIC Educational Resources Information Center

Presents a literature review of wastewater collection systems and components. This review covers: (1) planning, (2) construction; (3) sewer system evaluation; (4) maintenance; (5) rehabilitation; (6) overview prevention; and (7) wastewater pumping. A list of 111 references is also presented. (HM)

Chatterjee, Samar; And Others

1978-01-01

421

Collective Instinct  

Microsoft Academic Search

IN response to the appeal which closes Mr. Buck's interesting letter (NATURE, vol. viii. p. 332), the following instance of ``collective instinct'' exhibited by an animal closely allied to the wolf, viz., the Indian jackal, deserves to be recorded. It was communicated to me by a gentleman (since deceased) on whose veracity I can depend. Tnis gentleman was waiting in

George J. Romanes

1873-01-01

422

Distribution of bovine viral diarrhoea virus antigen in persistently infected white-tailed deer (Odocoileus virginianus).  

PubMed

Infection with bovine viral diarrhoea virus (BVDV), analogous to that occurring in cattle, is reported rarely in white-tailed deer (Odocoileus virginianus). This study evaluated the distribution of BVDV antigen in persistently infected (PI) white-tailed deer and compared the findings with those from PI cattle. Six PI fawns (four live-born and two stillborn) from does exposed experimentally to either BVDV-1 or BVDV-2 were evaluated. Distribution and intensity of antigen expression in tissues was evaluated by immunohistochemistry. Data were analyzed in binary fashion with a proportional odds model. Viral antigen was distributed widely and was present in all 11 organ systems. Hepatobiliary, integumentary and reproductive systems were respectively 11.8, 15.4 and 21.6 times more likely to have higher antigen scores than the musculoskeletal system. Pronounced labelling occurred in epithelial tissues, which were 1.9-3.0 times likelier than other tissues to contain BVDV antigen. Antigen was present in >90% of samples of liver and skin, suggesting that skin biopsy samples are appropriate for BVDV diagnosis. Moderate to severe lymphoid depletion was detected and may hamper reliable detection of BVDV in lymphoid organs. Muscle tissue contained little antigen, except for in the cardiovascular system. Antigen was present infrequently in connective tissues. In nervous tissues, antigen expression frequency was 0.3-0.67. In the central nervous system (CNS), antigen was present in neurons and non-neuronal cells, including microglia, emphasizing that the CNS is a primary target for fetal BVDV infection. BVDV antigen distribution in PI white-tailed deer is similar to that in PI cattle. PMID:22520818

Passler, T; Walz, H L; Ditchkoff, S S; van Santen, E; Brock, K V; Walz, P H

2012-11-01

423

The kidney biopsy in lupus nephritis: is it still relevant?  

PubMed

The kidney biopsy is the standard of care for diagnosis of lupus nephritis and remains necessary to ensure accurate diagnosis and guide treatment. Repeat biopsy should be considered when therapy modifications are necessary, as in cases with incomplete or no response, or when stopping therapy for those in remission. There are several promising biomarkers of kidney disorders; however, these markers need to be validated in a prospective clinical trial before being applied clinically. Molecular analysis may provide the information presently lacking from current evaluation of kidney disorders and may better inform on prognosis and treatment considerations. PMID:25034161

Rovin, Brad H; Parikh, Samir V; Alvarado, Anthony

2014-08-01

424

Context is everything: an unusual breast core biopsy case.  

PubMed

Changes in breast tissue in female-to-male transsexuals following gender reassignment and androgen therapy can cause difficulties in interpreting breast core biopsies. Clinical history and awareness of histological changes in breast tissue associated with androgen treatment are important in such cases. Specimen mislabeling is a potential pitfall to be borne in mind while evaluating unusual presentations in breast core biopsies. We report a case of a 58-year-old male with a well-defined supra areolar lesion clinically thought to be a fibroadenoma. PMID:23855022

Mathew, Hitesh; Hamid, Bushra

2013-10-01

425

Fully Fiber Optic Ultrasonic Probes for Virtual Biopsy  

NASA Astrophysics Data System (ADS)

The proposed probe consists of two optical fibers: one generating ultrasounds by opto-acoustic conversion, the second one, based on acousto-optic effect, used to detect ultrasounds. The intrinsic high frequency and wide bandwidth associated both to the opto-acoustic source and to the interferometric acousto-optic element could open a way towards a "virtual biopsy". "Virtual biopsy" is perspective to provide the physicians the possibility of studying the nature and health condition of small portions of living tissue "in situ" by using ultrasounds.

Biagi, E.; Cerbai, S.; Gambacciani, P.; Masotti, L.

426

[The role of echoendoscopic biopsy in diagnosing tuberculosis of pancreas].  

PubMed

The diagnosis of an abdominal mass using imaging techniques is difficult for clinicians and radiologists. We report a case of an atypical peripancreatic mass, mimicking a carcinoma on abdominal computed tomography and which was only diagnosed after an echoendoscopic biopsy of the mass was performed. It is difficult to differentiate abdominal tuberculosis from a neoplasm, especially if there is no pulmonary tuberculosis. Usually, the diagnosis of abdominal tuberculosis is only confirmed histologically, after surgical resection of the mass. Echoendoscopic biopsy confirmed the infectious nature of the mass and prevented complicated and difficult surgery. PMID:18341981

Coriat, R; Latournerie, M; Galtier, J-B; Michiels, C; Hillon, P; Manfredi, S

2008-01-01

427

[Pleural needle biopsy in diagnosis of pleural effusion].  

PubMed

Diagnostic reliability of percutaneous parietal pleural biopsy with use of the Abrams needle technique performed over a period 1989-1994 was assessed in 37 patients with pleural effusion of unknown etiology, aged 24-82 years. Adequate diagnostic specimens were obtained in 33 patients. Histopathological diagnosis established neoplasma (39,4%), tuberculosis (9.1%) and chronic nonspecific pleuritis (51,5%). No complications of the procedure were encountered. Pleural needle biopsy should be more widely applied as a basic method in the diagnosis of pleural effusions of unknown etiology. PMID:8630469

Fija?kowski, M; B?och, P; Kulig, A; Graczyk, J; Szmidt, M

1996-01-01

428

Biopsy of the Superficial Cortex: Predictors of Effectiveness and Outcomes  

PubMed Central

BACKGROUND Brain biopsies of superficial cortex are performed for diagnosis of neurological diseases, but preoperative predictors of successful diagnosis and risks are lacking. OBJECTIVE We evaluated effectiveness and outcomes of superficial cortical biopsies and determined preoperative predictors of diagnosis, outcomes, morbidities, and mortality. METHODS A single-institution retrospective analysis of 170 patients who underwent open brain biopsies of superficial cortex was performed. Clinical predictors of effectiveness and outcomes were determined using univariate/multivariate analyses and a system for risk-benefit stratification was created and tested. RESULTS Brain biopsies led to successful diagnosis in 122 of 170 (71.8%) and affected management in 97 of 170 (57.1%) cases. Factors increasing the odds of diagnostic pathology included age older than 45 years (odds ratio [OR]: 2.67, 95% confidence interval [CI]: 1.34-5.27, P < .01), previous cancer diagnosis (OR: 3.64, 95% CI: 1.69-7.85, P < .001), focal (OR: 3.90, 95% CI: 1.91-8.00, P < .001) and enhancing (OR: 5.03, 95% CI: 2.41-10.52, P < .001) lesions on magnetic resonance imaging, biopsy of specific lesions on magnetic resonance imaging (OR: 9.34, 95% CI: 4.29-20.33, P < .001), and use of intraoperative navigation (OR: 6.59, 95% CI: 3.04-14.28, P < .001). Brain biopsies led to symptomatic intracranial hemorrhage, seizures, other significant morbidities, and perioperative mortality in 12.4%, 16.2%, 37.1%, and 8% of cases, respectively. Risk of postoperative intracranial hemorrhage was increased by a history of aspirin use (OR: 2.51, 95% CI: 1.23-5.28, P < .05) and age older than 60 years (OR: 2.66, 95% CI: 1.36-5.18, P < .01). CONCLUSION Effectiveness and risk of morbidity/mortality can be estimated preoperatively for patients undergoing open brain biopsies of the superficial cortex. Older age and specific imaging characteristics increase the odds of diagnostic biopsy. Conversely, older age and aspirin use increases the risk of postoperative complications. PMID:23632761

Hawasli, Ammar H.; Buckley, Robert T.; Gao, Feng; Limbrick, David D.; Smyth, Matthew D.; Leonard, Jeffrey R.; Santiago, Paul; Stewart, Todd J.; Park, Tae S.; Grubb, Robert L.; Dowling, Joshua L.; Leuthardt, Eric C.; Rich, Keith M.; Zipfel, Gregory J.; Dacey, Ralph G.; Chicoine, Michael R.

2014-01-01

429

Wildlife and water: collective action and social capital of selected landowner associations in Texas  

E-print Network

In Texas, landowner associations for the management of common-pool resources such as wildlife and groundwater have become increasingly popular. Successful management of white-tailed deer (Odocoileus virginianus) depends upon the collective decision...

Wagner, Matthew Wayne

2007-04-25

430

ANTIBODY PREVALENCE OF EIGHT RUMINANT INFECTIOUS DISEASES IN CALIFORNIA MULE AND BLACK-TAILED DEER (ODOCOILEUS HEMIONUS)  

Microsoft Academic Search

We tested 276 sera from 18 free-ranging black-tailed and mule deer (Odocoileus hemionus) herds in California (USA) collected from 1987 to 1991 in five biogeographical habitat types, for antibodies against eight infectious disease agents. Overall antibody prevalence was 56% for Anaplasma marginale, 31% for Borrelia burgdorferi, 16% for bluetongue virus serotype 17, 15% for epizootic hemorrhagic disease virus, 7% for

Bruno B. Chomel; Marius L. Carniciu; Rickie W. Kasten; Paolo M. Castelli; Thierry M. Work; David A. Jessup

431

Roost Fidelity and Fission-Fusion Dynamics of White-Striped Free-Tailed Bats (Tadarida Australis)  

Microsoft Academic Search

The white-striped free-tailed bat (Tadarida australis) is a common species of insectivorous bat found in mainland Australia. Despite its abundance, very little is known about its roosting ecology. I used radiotelemetry collected during 3 seasons to examine roost fidelity and roosting associations of a summer roosting group. Bats were trapped at a large communal roost in subtropical urban Brisbane, Australia.

Monika Rhodes

2007-01-01

432

Monitoring Ovulation and Implantation in the Lion-Tailed Macaque (Macaca silenus) Through Urinary Estrone Conjugate Evaluations1  

Microsoft Academic Search

Urine samples were collected daily during ten nonfertile and four fertile ovarian cycles of four adult female lion-tailed macaques (Macaca silenus). Urine was analyzed for concentrations of total immunoreactive estrogen (Et), estrone conjugates, and bioactive luteinizing hormones (LH). The estrone conjugates of selected samples were separated by high-performance liquid chromatography (HPLC) to evaluate the relative proportions of estrone glucuronide (E,

N. M. CZEKALA; L. H. KASMAN; D. G. LINDBURG; B. L. LASLEY

433

Proposed ground water protection strategy for the Uranium Mill Tailings Site at Green River, Utah. Final report  

SciTech Connect

This document presents the US DOE water resources protection strategy for the Green River, Utah mill tailings disposal site. The modifications in the original plan are based on new information, including ground water quality data collected after remedial action was completed, and on a revised assessment of disposal cell design features, surface conditions, and site hydrogeology. All aspects are discussed in this report.

Not Available

1994-11-01

434

Possible Vector Dissemination by Swift Foxes following a Plague Epizootic in Black-tailed Prairie Dogs in Northwestern Texas  

Microsoft Academic Search

To determine whether swift foxes (Vulpes velox) could facilitate transmission of Yersinia pestis to uninfected black-tailed prairie dog (Cynomys ludovicianus) colonies by ac- quiring infected fleas, ectoparasite and sero- logic samples were collected from swift foxes living adjacent to prairie dog towns during a 2004 plague epizootic in northwestern Texas, USA. A previous study (1999-2001) indicated that these swift foxes

Brady K. McGee; Matthew J. Butler; Danny B. Pence; James L. Alexander; Janet B. Nissen

435

Baseline risk assessment of groundwater contamination at the Uranium Mill Tailings Site near Gunnison, Colorado  

SciTech Connect

This Baseline Risk Assessment of Groundwater Contamination at the Uranium Mill Tailings Site Near Gunnison, Colorado evaluates potential impacts to public health or the environment resulting from groundwater contamination at the former uranium mill processing site. The tailings and other contaminated material at this site are being placed in an off-site disposal cell by the US Department of Energy`s (DOE) Uranium Mill Tailings Remedial Action (UMTRA) Project. Currently, the UMTRA Project is evaluating groundwater contamination. This is the second risk assessment of groundwater contamination at this site. The first risk assessment was performed primarily to evaluate existing domestic wells. This risk assessment evaluates the most contaminated monitor wells at the processing site. It will be used to assist in determining what remedial action is needed for contaminated groundwater at the site after the tailings are relocated. This risk assessment follows an approach outlined by the US Environmental Protection Agency (EPA). The first step is to evaluate groundwater data collected from monitor wells at the site. Evaluation of these data showed that the main contaminants in the groundwater are cadmium, cobalt, iron, manganese, sulfate, uranium, and some of the products of radioactive decay of uranium.

Not Available

1993-12-01

436

Postoperative complications associated with caudectomy in brachycephalic dogs with ingrown tails.  

PubMed

Surgical correction of an ingrown tail is indicated to relieve clinical signs of intertriginous dermatitis. The objective of this retrospective study was to identify the type and frequency of complications following caudectomy in dogs with ingrown tails. Medical records of dogs with ingrown tails treated with caudectomy from 2000 to 2010 at the University of Georgia Veterinary Teaching Hospital were reviewed. Data collected included signalment, preoperative infection status, surgical procedures performed, prophylactic antibiotic use, complications noted both during hospitalization and at suture removal, treatments instituted, and owner satisfaction. Seventeen dogs were identified for inclusion. At presentation, 4 of the 17 dogs (23.5%) were receiving antibiotics. Infection was present in 7 of the 17 dogs (41%), and 6 of the 7 cases resolved immediately postoperatively. All dogs received perioperative antimicrobial therapy, and 13 of the 17 dogs (76%) received antibiotics after surgery for an average of 13.5 days ± 5.2 days. Complications occurred in 2 of the 17 cases (12%) immediately after surgery, including decreased rectal sensation with adequate anal tone, failure to posture to defecate, and postoperative draining tracts. Complications were reported in 2 of 15 dogs (13%) at suture removal, including delayed wound healing and wound inflammation, persistent tail chasing behavior, and temporary changes in defecation habits. Caudectomy provided resolution of clinical signs with no long-term complications. PMID:23690492

Knight, Shanna M; Radlinsky, MaryAnn G; Cornell, Karen K; Schmiedt, Chad W

2013-01-01

437

Tail-vein collection of blood: (mouse) Mice will be either manually or mechanically restraint for blood collection. The tip of tail will be  

E-print Network

gauge needle. No anesthesia is required. #12;Gavage: (mouse) Mice will be restrained by hand without will be marked to indicate the distance that the needle should be advanced into the oral cavity to deliver volumes and names of the solutions used for gavage should be included in the description.) Imaging

Oliver, Douglas L.

438

Classic lobular neoplasia on core biopsy: a clinical and radio-pathologic correlation study with follow-up excision biopsy.  

PubMed

There are no consensus guidelines for the management of lobular neoplasia diagnosed on core biopsy as the highest risk factor for cancer. This study aimed to assess the risk of upgrade (invasive carcinoma or ductal carcinoma in situ) at the site of the lobular neoplasia and any clinical, radiological or pathologic factors associated with the upgrade. We reviewed all cases with a diagnosis of lobular neoplasia on core biopsy from June 2006 to June 2011. Any cases with radio-pathologic discordance, coexistent lesion that required excision (atypical ductal hyperplasia, flat epithelial atypia, duct papilloma or radial scar) or non-classic variant of lobular carcinoma in situ (pleomorphic, mixed ductal and lobular, lobular carcinoma in situ with necrosis) were excluded from the study. Core biopsy indications included calcification in 35 (40%), non-mass like enhancement in 19 (22%), mass lesion in 31 (36%) and mass as well as calcification in two cases (2%). Follow-up excisions were studied for the presence of upgrade. The study cohort included 87 cases and showed an upgrade of 3.4% (95% confidence interval: 1-10%). Three cases showed an upgrade (one ductal carcinoma in situ and two invasive cancers). All upgraded cases were breast imaging-reporting and data system score ?4 and associated with atypical duct hyperplasia or in situ or invasive cancer in prior or concurrent biopsies in either breast. The number of cores and lobules involved, pagetoid duct involvement, presence of microcalcification in lobular neoplasia, needle gauge and number of cores obtained showed no correlation with the upgrade. Our results suggest that with radio-pathologic concordance and no prior biopsy proven risk for breast cancer, core biopsy finding of lobular neoplasia as the highest risk lesion can be appropriately and safely managed with clinical and radiologic follow-up as an alternative to surgical excision. PMID:23307062

Chaudhary, Shweta; Lawrence, Loretta; McGinty, Geraldine; Kostroff, Karen; Bhuiya, Tawfiqul

2013-06-01

439

Severe wear and tooth loss in wild ring-tailed lemurs ( Lemur catta): A function of feeding ecology, dental structure, and individual life history  

Microsoft Academic Search

The ring-tailed lemurs at Beza Mahafaly Special Reserve, Madagascar, exhibit a high frequency of severe wear and antemortem tooth loss. As part of a long-term study, we collected dental data on 83 living adult ring-tailed lemurs during 2003 and 2004. Among these individuals, 192 teeth were scored as absent. The most frequently missing tooth position is M1 (24%). As M1

Frank P. Cuozzo; Michelle L. Sauther

2006-01-01

440

Screening of Plant Species for Phytoremediation of Uranium, Thorium, Barium, Nickel, Strontium and Lead Contaminated Soils from a Uranium Mill Tailings Repository in South China  

Microsoft Academic Search

The concentrations of uranium, thorium, barium, nickel, strontium and lead in the samples of the tailings and plant species\\u000a collected from a uranium mill tailings repository in South China were analyzed. Then, the removal capability of a plant for\\u000a a target element was assessed. It was found that Phragmites australis had the greatest removal capabilities for uranium (820 ?g), thorium (103 ?g)

Guang-yue Li; Nan Hu; De-xin Ding; Ji-fang Zheng; Yu-long Liu; Yong-dong Wang; Xiao-qin Nie

2011-01-01

441

INFECTION OF WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) IN MICHIGAN WITH JAMESTOWN CANYON VIRUS (CALIFORNIA SEROGROUP) AND THE IMPORTANCE OF MATERNAL ANTIBODY IN VIRAL MAINTENANCE  

Microsoft Academic Search

Sera collected from a captive population of white-tailed deer (Odocoileusvirgini- anus) penned in the lower peninsula of Michigan were assayed over a 29-mo period for neutral- izing antibody to California serogroup viruses. In all, 130 individual white-tailed deer were bled one to 22 times between June 1983 and November 1985. Of the 130 sampled after active trans- mission had ceased,

Paul R. Grimstad; Diane G. Williams; Stephen M. SchmiW

442

Tailings basin reclamation: Atlantic City Iron Mine, Wyoming  

SciTech Connect

An 81 ha (200 ac) tailings impoundment at a taconite operation in Wyoming abandoned in 1985 has been a source of blowing dust. The site qualified for reclamation under Wyoming's Abandoned Mine Land program. The reclamation design included: incorporating commercially available organic amendments and fertilizers into a 300 mm (12 in.) thick cap of a sterile gravelly clay loam cover material, planting trees in the protective wind/snow shadows of rock beams and rock snow fences, lowering the water level n a flooded mine pit that was feeding uncontrolled seeps, and constructing a wide tailings pond spillway that allows flood control while minimizing seasonal water level fluctuations in the pond. The construction of the earthwork aspects of the design were completed over two construction seasons, including work during the winter at this high-altitude (2,470 m [8,100 ft.]) site. This occurred because snow from an early winter storm that collected behind the rock beams and rock snow fences was slow to melt. Furthermore, the increased snow catch made the site too wet the following spring to allow seeding during the normal seeding window; a fall planting was necessary. The rocky nature of the cover material prompted the development of innovative reclamation approaches, including fabricating a rock rake bulldozer blade and applying organic soil amendments by aerial spraying. A randomly-configured two-acre test plot was installed to evaluate the benefits of various soil amendments as the site matures. Future work on the site will include tree seedling planting and plugging of a decant pipeline.

Gusek, J.J.; Richmond, T.C.

1999-07-01

443

Single-Institution Results of Image-Guided Nonplugged Percutaneous Versus Transjugular Liver Biopsy  

SciTech Connect

Purpose: To retrospectively review patients who underwent transjugular and image-guided percutaneous biopsy and compare the relative risk of ascites, thrombocytopenia, and coagulopathy. Materials and Methods: From August 2001 through February 2006, a total of 238 liver biopsies were performed. The radiologist reviewed all patient referrals for transjugular biopsy. These patients either underwent transjugular biopsy or were reassigned to percutaneous biopsy (crossover group). Patients referred to percutaneous image-guided liver biopsy underwent this same procedure. Biopsies were considered successful if a tissue diagnosis could be made from the samples obtained. Results: A total of 36 transjugular biopsies were performed with 3 total (8.3%) and 1 major (2.8%) complications. A total of 171 percutaneous biopsies were performed with 10 (5.8%) total and 3 (1.8%) major complications. The crossover group showed a total of 4 (12.9%) complications with 1 (3.2%) major complication. Sample adequacy was 91.9% for transjugular and 99.5% for percutaneous biopsy. Conclusion: Both transjugular and percutaneous liver biopsy techniques are efficacious and safe. Contraindications such as thrombocytopenia, coagulopathy, and ascites are indicators of greater complications but are not necessarily prevented by transjugular biopsy. Percutaneous biopsy more frequently yields a diagnostic specimen than transjugular biopsy.

Hardman, Rulon L., E-mail: hardmanr@uthscsa.edu [University of Texas Health Science Center San Antonio (United States); Perrich, Kiley D.; Silas, Anne M. [Dartmouth-Hitchcock Medical Center, Division of Vascular and Interventional Radiology (United States)

2011-04-15

444

Liver biopsy in a district general hospital: Changes over two decades  

PubMed Central

AIM: To study liver biopsy practice over two decades in a district general hospital in the United Kingdom. METHODS: We identified all patients who had at least one liver biopsy between 1986 and 2006 from the databases of the radiology and gastroenterology departments. Subjects with incomplete clinical data were excluded from the study. RESULTS: A total of 103 liver biopsies were performed. Clinical data was available for 88 patients, with 95 biopsies. Between 1986 and 1996, 18 (95%) out of the 19 liver biopsies performed were blind and 6 (33%) were for primary biliary cirrhosis. Between 1996 and 2006, 14 (18%) out of 76 biopsies were blind; and the indications were abnormal liver tests (33%), hepatitis C (12%) and targeted-biopsies (11%). Liver biopsies were unhelpful in 5 (5%) subjects. Pain was the most common complication of liver biopsy (5%). No biopsy-related mortality was reported. There was a trend towards more technical failures and complications with the blind biopsy technique. CONCLUSION: Liver biopsies performed in small district hospitals are safe and useful for diagnostic and staging purposes. Abnormal liver tests, non-alcoholic fatty liver disease and targeted biopsies are increasingly common indications. Ultrasound-guided liver biopsies are now the preferred method and are associated with fewer complications. PMID:17879403

Syn, Wing-Kin; Bruckner-Holt, Caroline; Farmer, Adam; Howdle, Sarah; Bateman, Jeffrey

2007-01-01

445

Double inlet ventricle. Lung biopsy findings and implications for management  

Microsoft Academic Search

The lung was biopsied in 20 children with double inlet ventricle and pulmonary hypertension aged 2 months to 14 years. Eleven patients had two patent atrioventricular valves, three atresia of the right valve, and six hypoplasia of the left valve. Severe pulmonary arterial medial hypertrophy occurred in the nine children less than 1 year of age. The findings did not

E Juaneda; S G Haworth

1985-01-01

446

Diagnosis of infantile neuroaxonal dystrophy by skin biopsy.  

PubMed

Skin biopsy with ultrastructural examination of cutaneous nerves showed dystrophic axons (spheroids), confirming a diagnosis of infantile neuroaxonal dystrophy. Independent of axonal changes, a few endoneurial and Schwann cells showed cytoplasmic inclusion bodies composed of structures similar to those seen in the spheroids. PMID:6246837

Wisniewski, K; Wisniewski, H M

1980-04-01

447

Skin and conjunctival biopsies in infantile neuroaxonal dystrophy  

Microsoft Academic Search

The diagnosis of infantile neuro-axonal dystrophy (INAD) in a 5-year-old patient was confirmed by the ultrastructural study of neuromuscular, skin and conjunctival biopsy specimens. Abnormal networks of smooth membranous, lamellar and tubular profiles were found in presynaptic terminals and in conjunctival and dermal axons.

J. J. Martin; J. G. Leroy; J. Libert; M. van Eygen; N. Logghe

1979-01-01

448

Technical procedures and staining methods for renal needle biopsies.  

PubMed

Procedures specifically developed for kidney needle biopsies are presented. These procedures may be applied to improve the slide quality of all small specimens. Fixation, processing, knife sharpening, cutting, and staining procedures used by the author are discussed. A modification of the Jones method for basement membranes is given. PMID:59547

Sugulas, M

1976-06-01

449

[Experiences with drill biopsy in the diagnosis of breast tumors].  

PubMed

We report on our experiences of 598 drill biopsies in 581 female patients. The method is suitable for clarification of dubious palpatory findings in the breast, for verification of relapse, and for receptor analysis in individual cases. It is simple to carry out, almost free of complications and provides sufficient tissue for rapid-section diagnostics. It has a high precision (90% to 92%): no false positive results were noted. The advantage, compared to excision biopsy, consists of the shortening of the duration of operation and anesthesia and better diagnostic clarification. The problem of the excision cavity is avoided. In case of a mastectomy or quadrantectomy, the primary tumor and remains connected with the tissue surrounding the tumor is available in toto for histological examination. The risk of tumor cell dissemination from drillbiopsy did not appear to be increased. The limitations of the method apply to small (less than 1 cm) not definitely palpable tumors near to the thorax wall in large, voluminous breasts. The diagnosis of specific histological types requires a high degree of experience in ultrastructural appraisal of breast tissue. A negative drill biopsy should be followed by an excision biopsy, where a carcinoma is suspected. PMID:2737435

Adam, R; Falter, E; Düll, W; Reitzenstein, M; Tulusan, A H

1989-05-01

450

Percutaneous Renal and Hepatic Biopsy in Rhesus Monkeys.  

National Technical Information Service (NTIS)

Percutaneous biopsy of kidney and liver, using the Menghini needle, was developed as a safe, simple, and rapid procedure that could be used repeatedly on the same monkey. This intermittent harvest of tissue avoided the need to kill several monkeys during ...

C. G. Huizenga

1971-01-01

451

Segmentation of prostate biopsy needles in transrectal ultrasound images  

NASA Astrophysics Data System (ADS)

Prostate cancer is the most common cancer in men. Tissue extraction at different locations (biopsy) is the gold-standard for diagnosis of prostate cancer. These biopsies are commonly guided by transrectal ultrasound imaging (TRUS). Exact location of the extracted tissue within the gland is desired for more specific diagnosis and provides better therapy planning. While the orientation and the position of the needle within clinical TRUS image are limited, the appearing length and visibility of the needle varies strongly. Marker lines are present and tissue inhomogeneities and deflection artefacts may appear. Simple intensity, gradient oder edge-detecting based segmentation methods fail. Therefore a multivariate statistical classificator is implemented. The independent feature model is built by supervised learning using a set of manually segmented needles. The feature space is spanned by common binary object features as size and eccentricity as well as imaging-system dependent features like distance and orientation relative to the marker line. The object extraction is done by multi-step binarization of the region of interest. The ROI is automatically determined at the beginning of the segmentation and marker lines are removed from the images. The segmentation itself is realized by scale-invariant classification using maximum likelihood estimation and Mahalanobis distance as discriminator. The technique presented here could be successfully applied in 94% of 1835 TRUS images from 30 tissue extractions. It provides a robust method for biopsy needle localization in clinical prostate biopsy TRUS images.

Krefting, Dagmar; Haupt, Barbara; Tolxdorff, Thomas; Kempkensteffen, Carsten; Miller, Kurt

2007-03-01

452

Contraindications of sentinel lymph node biopsy: Áre there any really?  

Microsoft Academic Search

BACKGROUND: One of the most exciting and talked about new surgical techniques in breast cancer surgery is the sentinel lymph node biopsy. It is an alternative procedure to standard axillary lymph node dissection, which makes possible less invasive surgery and side effects for patients with early breast cancer that wouldn't benefit further from axillary lymph node clearance. Sentinel lymph node

George M Filippakis; George Zografos

2007-01-01

453

Contraindications and Safety of Transbronchial Lung Biopsy via Flexible Bronchoscopy  

Microsoft Academic Search

Background: Transbronchial lung biopsy (TBLB) via flexible bronchoscopy is a common procedure performed by pulmonologists. Limited scientific data exist concerning the risk of this procedure in patients with conditions that may adversely affect the rate of procedural complications. Objectives: To evaluate the current practice pattern and attitude of pulmonologists toward the performance of TBLB in the presence of high-risk conditions.

Momen M. Wahidi; Ana T. Rocha; John W. Hollingsworth; Joseph A. Govert; David Feller-Kopman; Armin Ernst

2005-01-01

454

Utility of a Biopsy in Suspicious Pigmented Iris Tumors  

Microsoft Academic Search

Background: In the presence of pigmented iris lesions evocative of malignant melanoma and implying oncological treatment, a foregoing biopsy to exclude a benign lesion may seem a reasonable approach. After examining patient files, the utility of such a diagnostic approach was explored. Material and Methods: Retrospective, consecutive histopathologic case series of 10 pigmented iris tumor specimens excised since 1993. Histopathologic

Ann Schalenbourg; Sylvie Uffer; Leonidas Zografos

2008-01-01

455