77 FR 59703 - Environmental Impact Statement; Taos Regional Airport, Taos, NM
Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-28
... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Environmental Impact Statement; Taos...'' Environmental Impact Statement (EIS). The Town of Taos, owner and operator of Taos Regional Airport located in Taos, New Mexico, has requested the FAA to approve revisions to its Airport Layout Plan (ALP) to...
CAI Update: So You Want to Do CAI?
ERIC Educational Resources Information Center
Bagley, Carole
1979-01-01
Provides necessary characteristics to consider when selecting a CAI system plus a list of costs and capabilities available with the better known CAI systems. Characteristics of major CAI systems are presented in three categories--large/maxi, mini, and micro systems--in chart form. (JEG)
1998-01-01
ARCHIVE COPY . NATIONAL DEFENSE UNIVERSITY NATIONAL WAR COLLEGE The Tao of Nelson Tao rnvarzably takes no actron, and yet there IS nothing left...1998 to 00-00-1998 4. TITLE AND SUBTITLE The Tao of Nelson 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution
CAI and Developmental Education.
ERIC Educational Resources Information Center
Anderson, Rick
This paper discusses the problems and achievements of computer assisted instruction (CAI) projects at University College, University of Cincinnati. The most intensive use of CAI on campus, the CAI Lab, is part of the Developmental Education Center's effort to serve students who lack mastery of basic college-level skills in mathematics and English.…
ERIC Educational Resources Information Center
Kearsley, G.P.; Hunka, S.
The application of copyright laws to Computer Assisted Instruction (CAI) is not a simple matter of extending traditional literary practices because of the legal complications introduced by the use of computers to store and reproduce materials. In addition, CAI courseware poses some new problems for the definitions of educational usage. Some…
NDBC Tropical Atmosphere Ocean (TAO)
to go to the NWS homepage Left navigation bar Home News Organization Search NDBC web site search TAO Tour FAQ NDBC Home Contact Us USA.gov is the U.S. government's official web portal to all federal , state and local government web resources and services. Recent Data Observations Search TAO DART Tropical
NASA Technical Reports Server (NTRS)
Tighe, Michael F.
1986-01-01
Intermetrics' experience is that the Ada package construct, which allows separation of specification and implementation allows specification of a CAIS that is transportable across varying hardware and software bases. Additionally, the CAIS is an excellent basis for providing operating system functionality to Ada applications. By allowing the Byron APSE to be moved easily from system to system, and allowing significant re-writes of underlying code. Ada and the CAIS provide portability as well as transparency to change at the application operating system interface level.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-20
... County, NM; Taos Ski Valley's 2010 Master Development Plan--Phase 1 Projects; Additional Filings AGENCY... environmental impact statement for a proposal to authorize several (Phase 1) projects included in the Taos Ski... (ROD) are expected in July 2012. Change in Responsible Official: In addition, this notice changes the...
Update on TAO moored ORG array
NASA Technical Reports Server (NTRS)
Freitag, H. Paul
1994-01-01
During the Coupled Ocean Atmosphere Response Experiment (COARE) six TAO moorings were equipped with optical rain gauges (ORG's). In late 1993 moorings deployed on the equator at 154E and 157.5E were recovered and not redeployed as they were augmentations to the TAO array for COARE only. In December 1993, four TAO moorings were equipped with ORG's: one each at 2N, 156E and 2S, 156E and ORG doublets on the equator at 0, 156E and 0, 165E. The 2N, 156E mooring has been lost. By the end of April all sites will have been serviced and six refurbished sensors will again be deployed in the same locations.
CAI System Costs: Present and Future.
ERIC Educational Resources Information Center
Pressman, Israel; Rosenbloom, Bruce
1984-01-01
Discusses costs related to providing computer assisted instruction (CAI), considering hardware, software, user training, maintenance, and installation. Provides an example of the total cost of CAI broken down into these categories, giving an adjusted yearly cost. Projects future trends and costs of CAI as well as cost savings possibilities. (JM)
TAO kinases mediate activation of p38 in response to DNA damage
Raman, Malavika; Earnest, Svetlana; Zhang, Kai; Zhao, Yingming; Cobb, Melanie H
2007-01-01
Thousand and one amino acid (TAO) kinases are Ste20p-related MAP kinase kinase kinases (MAP3Ks) that activate p38 MAPK. Here we show that the TAO kinases mediate the activation of p38 in response to various genotoxic stimuli. TAO kinases are activated acutely by ionizing radiation, ultraviolet radiation, and hydroxyurea. Full-length and truncated fragments of dominant negative TAOs inhibit the activation of p38 by DNA damage. Inhibition of TAO expression by siRNA also decreases p38 activation by these agents. Cells in which TAO kinases have been knocked down are less capable of engaging the DNA damage-induced G2/M checkpoint and display increased sensitivity to IR. The DNA damage kinase ataxia telangiectasia mutated (ATM) phosphorylates TAOs in vitro; radiation induces phosphorylation of TAO on a consensus site for phosphorylation by the ATM protein kinase in cells; and TAO and p38 activation is compromised in cells from a patient with ataxia telangiectasia that lack ATM. These findings indicate that TAO kinases are regulators of p38-mediated responses to DNA damage and are intermediates in the activation of p38 by ATM. PMID:17396146
Astrophysics of CAI formation as revealed by silicon isotope LA-MC-ICPMS of an igneous CAI
NASA Astrophysics Data System (ADS)
Shahar, Anat; Young, Edward D.
2007-05-01
Silicon isotope ratios of a typical CAI from the Leoville carbonaceous chondrite, obtained in situ by laser ablation MC-ICPMS, together with existing 25Mg/ 24Mg data, reveal a detailed picture of the astrophysical setting of CAI melting and subsequent heating. Models for the chemical and isotopic effects of evaporation of the molten CAI are used to produce a univariant relationship between PH 2 and time during melting. The result shows that this CAI was molten for a cumulative time of no more than 70 days and probably less than 15 days depending on temperature. The object could have been molten for an integrated time of just a few hours if isotope ratio zoning was eliminated after melting by high subsolidus temperatures (e.g., > 1300 K) for ˜ 500 yr. In all cases subsolidus heating sufficient to produce diffusion-limited isotope fractionation at the margin of the solidified CAI is required. These stable isotope data point to a two-stage history for this igneous CAI involving melting for a cumulative timescale of hours to months followed by subsolidus heating for years to hundreds of years. The thermobarometric history deduced from combining Si and Mg isotope ratio data implicates thermal processing in the disk, perhaps by passage through shockwaves, following melting. This study underscores the direct link between the meaning of stable isotope ratio zoning, or lack thereof, and the inferred astrophysical setting of melting and subsequent processing of CAIs.
Bankey, Viki; Grauch, V.J.S.; ,
2004-01-01
This report contains digital data, image files, and text files describing data formats and survey procedures for aeromagnetic data collected during a helicopter geophysical survey in northern New Mexico during October 2003. The survey covers the Town of Taos, Taos Pueblo, and surrounding communities in Taos County. Several derivative products from these data are also presented, including reduced-to-pole, horizontal gradient magnitude, and downward continued grids and images.
2004-12-09
Trong Bui, NASA Dryden's principal investigator for the aerospike rocket tests, holds the first of two 10-ft. long rockets that were flown at speeds up to Mach 1.5, the first known supersonic tests of rockets with aerospike nozzles. The goals of the flight research project were to obtain aerospike rocket nozzle performance data in flight and to investigate the effects of transonic flow and transient flight conditions on aerospike nozzle performance.
Numerical simulation and validation of SI-CAI hybrid combustion in a CAI/HCCI gasoline engine
NASA Astrophysics Data System (ADS)
Wang, Xinyan; Xie, Hui; Xie, Liyan; Zhang, Lianfang; Li, Le; Chen, Tao; Zhao, Hua
2013-02-01
SI-CAI hybrid combustion, also known as spark-assisted compression ignition (SACI), is a promising concept to extend the operating range of CAI (Controlled Auto-Ignition) and achieve the smooth transition between spark ignition (SI) and CAI in the gasoline engine. In this study, a SI-CAI hybrid combustion model (HCM) has been constructed on the basis of the 3-Zones Extended Coherent Flame Model (ECFM3Z). An ignition model is included to initiate the ECFM3Z calculation and induce the flame propagation. In order to precisely depict the subsequent auto-ignition process of the unburned fuel and air mixture independently after the initiation of flame propagation, the tabulated chemistry concept is adopted to describe the auto-ignition chemistry. The methodology for extracting tabulated parameters from the chemical kinetics calculations is developed so that both cool flame reactions and main auto-ignition combustion can be well captured under a wider range of thermodynamic conditions. The SI-CAI hybrid combustion model (HCM) is then applied in the three-dimensional computational fluid dynamics (3-D CFD) engine simulation. The simulation results are compared with the experimental data obtained from a single cylinder VVA engine. The detailed analysis of the simulations demonstrates that the SI-CAI hybrid combustion process is characterised with the early flame propagation and subsequent multi-site auto-ignition around the main flame front, which is consistent with the optical results reported by other researchers. Besides, the systematic study of the in-cylinder condition reveals the influence mechanism of the early flame propagation on the subsequent auto-ignition.
ERIC Educational Resources Information Center
Gerhold, George; And Others
This paper describes an effective microprocessor-based CAI system which has been repeatedly tested by a large number of students and edited accordingly. Tasks not suitable for microprocessor based systems (authoring, testing, and debugging) were handled on larger multi-terminal systems. This approach requires that the CAI language used on the…
CAI at CSDF: Organizational Strategies.
ERIC Educational Resources Information Center
Irwin, Margaret G.
1982-01-01
The computer assisted instruction (CAI) program at the California School for the Deaf, at Fremont, features individual Apple computers in classrooms as well as in CAI labs. When the whole class uses computers simultaneously, the teacher can help individuals, identify group weaknesses, note needs of the materials, and help develop additional CAI…
Transient Astrophysics Observatory (TAO)
NASA Astrophysics Data System (ADS)
Racusin, J. L.; TAO Team
2016-10-01
The Transient Astrophysics Observatory (TAO) is a NASA MidEx mission concept (formerly known as Lobster) designed to provide simultaneous wide-field gamma-ray, X-ray, and near-infrared observations of the sky.
A risk management approach to CAIS development
NASA Technical Reports Server (NTRS)
Hart, Hal; Kerner, Judy; Alden, Tony; Belz, Frank; Tadman, Frank
1986-01-01
The proposed DoD standard Common APSE Interface Set (CAIS) was developed as a framework set of interfaces that will support the transportability and interoperability of tools in the support environments of the future. While the current CAIS version is a promising start toward fulfilling those goals and current prototypes provide adequate testbeds for investigations in support of completing specifications for a full CAIS, there are many reasons why the proposed CAIS might fail to become a usable product and the foundation of next-generation (1990'S) project support environments such as NASA's Space Station software support environment. The most critical threats to the viability and acceptance of the CAIS include performance issues (especially in piggybacked implementations), transportability, and security requirements. To make the situation worse, the solution to some of these threats appears to be at conflict with the solutions to others.
ERIC Educational Resources Information Center
Crawford, Lyall
What can philosophical Taoism teach us about interpersonal conflict and effective approaches for dealing with it? Examination of selected portions of the R. Hendricks translation of the "Lao-Tzu" or "Te-Tao Ching," and experiences recorded in fieldnotes while a member of a Taoist commune suggest a four-point protocol for…
The Screen Display Syntax for CAI.
ERIC Educational Resources Information Center
Richards, Boyd F.; Salisbury, David F.
1987-01-01
Describes four storyboard techniques frequently used in designing computer assisted instruction (CAI) programs, and explains screen display syntax (SDS), a new technique combining the major advantages of the storyboard techniques. SDS was developed to facilitate communication among designers, programmers, and editors working on a large CAI basic…
ERIC Educational Resources Information Center
Pressman, Israel; Rosenbloom, Bruce
1984-01-01
Describes and evaluates costs of hardware, software, training, and maintenance for computer assisted instruction (CAI) as they relate to total system cost. An example of an educational system provides an illustration of CAI cost analysis. Future developments, cost effectiveness, affordability, and applications in public and private environments…
Implications of Windowing Techniques for CAI.
ERIC Educational Resources Information Center
Heines, Jesse M.; Grinstein, Georges G.
This paper discusses the use of a technique called windowing in computer assisted instruction to allow independent control of functional areas in complex CAI displays and simultaneous display of output from a running computer program and coordinated instructional material. Two obstacles to widespread use of CAI in computer science courses are…
Lessons from the Tao for birthing practice.
Overman, B
1994-06-01
The metaphysics of the Tao Te Ching, as the basic structure of the universe, is used to examine birthing as creation. Lessons from the Tao regarding cultivating naturalness are drawn upon to provide suggestions for women in preparation for birthing, as well as for the nurses and midwives who attend them. Compatibility of this metaphysical view of birthing with Rogers's and Newman's nursing theories is identified, and the importance of honoring the metaphysical and spiritual aspects of birthing in nursing practice is stressed.
NALDA (Naval Aviation Logistics Data Analysis) CAI (computer aided instruction)
DOE Office of Scientific and Technical Information (OSTI.GOV)
Handler, B.H.; France, P.A.; Frey, S.C.
Data Systems Engineering Organization (DSEO) personnel developed a prototype computer aided instruction CAI system for the Naval Aviation Logistics Data Analysis (NALDA) system. The objective of this project was to provide a CAI prototype that could be used as an enhancement to existing NALDA training. The CAI prototype project was performed in phases. The task undertaken in Phase I was to analyze the problem and the alternative solutions and to develop a set of recommendations on how best to proceed. The findings from Phase I are documented in Recommended CAI Approach for the NALDA System (Duncan et al., 1987). Inmore » Phase II, a structured design and specifications were developed, and a prototype CAI system was created. A report, NALDA CAI Prototype: Phase II Final Report, was written to record the findings and results of Phase II. NALDA CAI: Recommendations for an Advanced Instructional Model, is comprised of related papers encompassing research on computer aided instruction CAI, newly developing training technologies, instructional systems development, and an Advanced Instructional Model. These topics were selected because of their relevancy to the CAI needs of NALDA. These papers provide general background information on various aspects of CAI and give a broad overview of new technologies and their impact on the future design and development of training programs. The paper within have been index separately elsewhere.« less
Application of deep learning in the identification of TAO
NASA Astrophysics Data System (ADS)
Wu, Cong; Jin, Jicheng
2018-03-01
Thyroid associated ophthalmopathy (TAO) is one of the most common orbital disease, it can be easily detected by the human eye in the late onset due to obvious changes in extraocular muscles. But in the early stage, it is not easy to be distinguish by doctors with eye because of subtle changes in extraocular muscles, so it is a good way to use the computer's ability to assist doctors to pre-diagnosis of TAO for follow-up treatment. In this paper, according to the routine diagnosis process of doctors, a comprehensive detection system network is proposed. The network consists of three different convolutional neural subnetwork, corresponding to three bitmaps of eye CT images .Finally, the output of three subnetwork are combined to generate final diagnostic result by the majority vote. Through the experiment, the detection system, whose recognition rata is 94.87%, has a good ability to identify the characteristics of TAO, can assist the doctor in the early diagnosis of TAO in a certain extent, so as to help early patients get timely treatment.
The Evolutionary Development of CAI Hardware.
ERIC Educational Resources Information Center
Stifle, John E.
After six years of research in computer assisted instruction (CAI) using PLATO III, a decision was made at the University of Illinois to develop a larger system as a national CAI resource. This document describes the design specifications and problems in the development of PLATO IV, a system which is capable of accomodating up to 4,000 terminals…
Creation and Distribution of CAIs in the Protoplanetary Nebula
NASA Technical Reports Server (NTRS)
Cuzzi, J. N.; Davis, S. S.; Dobrovolskis, A. R.
2003-01-01
CaAl rich refractory mineral inclusions (CAIs) found at 1 - 10% mass fraction in primitive chondrites appear to be several million years older than the dominant (chondrule) components in the same parent bodies. A prevalent concern is that it is difficult to retain CAIs for this long against gas-drag-induced radial drift into the sun. We assess a hot inner (turbulent) nebula context for CAI formation, using analytical models of nebula evolution and particle diffusion. We show that outward radial diffusion in a weakly turbulent nebula can prevent significant numbers of CAI-size particles from being lost into the sun for times of 1 - 3 x 10(exp 6) years. To match the CAI abundances quantitatively, we advocate an enhancement of the inner hot nebula in silicate-forming material, due to rapid inward migration of very primitive, silicate and carbon rich, meter-sized objects. 'Combustion' of the carbon into CO would make the CAI formation environment more reduced than solar, as certain observations imply. Abundant CO might also play a role in mass-independent chemical fractionation of oxygen isotopes as seen in CAIs and associated primitive, high-temperature condensates.
TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes
Shrestha, Roshan L.; Tamura, Naoka; Fries, Anna; Levin, Nicolas; Clark, Joanna; Draviam, Viji M.
2014-01-01
Chromosomal instability can arise from defects in chromosome–microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density of growing interphase and mitotic microtubules in human cells, showing TAO1's role in controlling microtubule dynamics. We demonstrate the aneugenic nature of chromosome–microtubule attachment defects in TAO1-depleted cells using an error-correction assay. Our model further strengthens the emerging paradigm that microtubule regulatory pathways are important for resolving erroneous kinetochore–microtubule attachments and maintaining the integrity of the genome, regardless of the spindle checkpoint status. PMID:24898139
ERIC Educational Resources Information Center
Richert, E. Susanne
1986-01-01
The author considers the need for a philosophical foundation for gifted education and suggests the Tao Te Ching education can reconcile the dichotomies in the field and encompass the various cognitive, affective, ethical, and esthetic taxonomies in existence. (CL)
ERIC Educational Resources Information Center
Christie, Patrick
This book shares the philosophy that what a teacher learned through the martial arts form, Aikido, allowed him to look beyond aggressive acts without responding aggressively himself, viewing the student behind the angry behavior. The teacher notes that compassion works better than any form of discipline he has ever encountered in education. Tao,…
Computers for Your Classroom: CAI and CMI.
ERIC Educational Resources Information Center
Thomas, David B.; Bozeman, William C.
1981-01-01
The availability of compact, low-cost computer systems provides a means of assisting classroom teachers in the performance of their duties. Computer-assisted instruction (CAI) and computer-managed instruction (CMI) are two applications of computer technology with which school administrators should become familiar. CAI is a teaching medium in which…
Research on TRIZ and CAIs Application Problems for Technology Innovation
NASA Astrophysics Data System (ADS)
Li, Xiangdong; Li, Qinghai; Bai, Zhonghang; Geng, Lixiao
In order to realize application of invent problem solve theory (TRIZ) and computer aided innovation software (CAIs) , need to solve some key problems, such as the mode choice of technology innovation, establishment of technology innovation organization network(TION), and achievement of innovative process based on TRIZ and CAIs, etc.. This paper shows that the demands for TRIZ and CAIs according to the characteristics and existing problem of the manufacturing enterprises. Have explained that the manufacturing enterprises need to set up an open TION of enterprise leading type, and achieve the longitudinal cooperation innovation with institution of higher learning. The process of technology innovation based on TRIZ and CAIs has been set up from researching and developing point of view. Application of TRIZ and CAIs in FY Company has been summarized. The application effect of TRIZ and CAIs has been explained using technology innovation of the close goggle valve product.
NASA Technical Reports Server (NTRS)
Mishra, R. K.; Simon, J. I.; Ross, D. K.; Marhas, K. K.
2016-01-01
Calcium, Aluminum-rich inclusions (CAIs) are the first forming solids of the Solar system. Their observed abundance, mean size, and mineralogy vary quite significantly between different groups of chondrites. These differences may reflect the dynamics and distinct cosmochemical conditions present in the region(s) of the protoplanetary disk from which each type likely accreted. Only about 11 such objects have been found in L and LL type while another 57 have been found in H type ordinary chondrites, compared to thousands in carbonaceous chondrites. At issue is whether the rare CAIs contained in ordinary chondrites truly reflect a distinct population from the inclusions commonly found in other chondrite types. Semarkona (LL3.00) (fall, 691 g) is the most pristine chondrite available in our meteorite collection. Here we report petrography and mineralogy of 3 CAIs from Semarkona
The Effect of CAI on Reading Achievement.
ERIC Educational Resources Information Center
Hardman, Regina
A study determined whether computer assisted instruction (CAI) had an effect on students' reading achievement. Subjects were 21 randomly selected fourth-grade students at D. S. Wentworth Elementary School on the south side of Chicago in a low-income neighborhood who received a year's exposure to a CAI program, and 21 randomly selected students at…
Evaluation Criteria for Micro-CAI: A Psychometric Approach
Wallace, Douglas; Slichter, Mark; Bolwell, Christine
1985-01-01
The increased use of microcomputer-based instructional programs has resulted in a greater need for third-party evaluation of the software. This in turn has prompted the development of micro-CAI evaluation tools. The present project sought to develop a prototype instrument to assess the impact of CAI program presentation characteristics on students. Data analysis and scale construction was conducted using standard item reliability analyses and factor analytic techniques. Adequate subscale reliabilities and factor structures were found, suggesting that a psychometric approach to CAI evaluation may possess some merit. Efforts to assess the utility of the resultant instrument are currently underway.
NASA Astrophysics Data System (ADS)
Aléon, Jérôme; Marin-Carbonne, Johanna; McKeegan, Kevin D.; El Goresy, Ahmed
2018-07-01
Oxygen, magnesium, and silicon isotopic compositions in the mineralogically complex, ultrarefractory (UR) calcium-aluminum-rich inclusion (CAI) E101.1 from the reduced CV3 chondrite Efremovka confirm that E101.1 is a compound CAI composed of several lithological units that were once individual CAIs, free-floating in the solar protoplanetary disk. Each precursor unit was found to have had its own thermal history prior to being captured and incorporated into the partially molten host CAI. Four major lithological units can be distinguished on the basis of their isotopic compositions. (1) Al-diopside-rich sinuous fragments, hereafter sinuous pyroxene, are 16O-rich (Δ17O ≤ -20‰) and have light Mg and Si isotopic compositions with mass fractionation down to -3.5‰/amu for both isotopic systems. We attribute these peculiar isotopic compositions to kinetic effects during condensation out of thermal equilibrium. (2) Spinel clusters are 16O-rich (Δ17O ∼ -22‰) and have Mg isotope systematics consistent with extensive equilibration with the host melt. This includes (i) δ25Mg values varying between + 2.6‰ and + 6.5‰ close to the typical value of host melilite at ∼+5‰, and (ii) evidence for exchange of radiogenic 26Mg with adjacent melilite as indicated by Al/Mg systematics. The spinel clusters may represent fine-grained spinel-rich proto-CAIs captured, partially melted, and recrystallized in the host melt. Al/Mg systematics indicate that both the sinuous pyroxene fragments and spinel clusters probably had canonical or near-canonical 26Al contents before partial equilibration. (3) The main CAI host (Δ17O ≤ -2‰) had a complex thermal history partially obscured by subsequent capture and assimilation events. Its formation, referred to as the "cryptic" stage, could have resulted from the partial melting and crystallization of a 16O-rich precursor that underwent 16O-depletion and a massive evaporation event characteristic of F and FUN CAIs (Fractionated with
Oxygen Isotope Measurements of a Rare Murchison Type A CAI and Its Rim
NASA Technical Reports Server (NTRS)
Matzel, J. E. P.; Simon, J. I.; Hutcheon, I. D.; Jacobsen, B.; Simon, S. B.; Grossman, L.
2013-01-01
Ca-, Al-rich inclusions (CAIs) from CV chondrites commonly show oxygen isotope heterogeneity among different mineral phases within individual inclusions reflecting the complex history of CAIs in both the solar nebula and/or parent bodies. The degree of isotopic exchange is typically mineral-specific, yielding O-16-rich spinel, hibonite and pyroxene and O-16-depleted melilite and anorthite. Recent work demonstrated large and systematic variations in oxygen isotope composition within the margin and Wark-Lovering rim of an Allende Type A CAI. These variations suggest that some CV CAIs formed from several oxygen reservoirs and may reflect transport between distinct regions of the solar nebula or varying gas composition near the proto-Sun. Oxygen isotope compositions of CAIs from other, less-altered chondrites show less intra-CAI variability and 16O-rich compositions. The record of intra-CAI oxygen isotope variability in CM chondrites, which commonly show evidence for low-temperature aqueous alteration, is less clear, in part because the most common CAIs found in CM chondrites are mineralogically simple (hibonite +/- spinel or spinel +/- pyroxene) and are composed of minerals less susceptible to O-isotopic exchange. No measurements of the oxygen isotope compositions of rims on CAIs in CM chondrites have been reported. Here, we present oxygen isotope data from a rare, Type A CAI from the Murchison meteorite, MUM-1. The data were collected from melilite, hibonite, perovskite and spinel in a traverse into the interior of the CAI and from pyroxene, melilite, anorthite, and spinel in the Wark-Lovering rim. Our objectives were to (1) document any evidence for intra-CAI oxygen isotope variability; (2) determine the isotopic composition of the rim minerals and compare their composition(s) to the CAI interior; and (3) compare the MUM-1 data to oxygen isotope zoning profiles measured from CAIs in other chondrites.
CAI System of Obunsha Co., Ltd. Using CD-ROM
NASA Astrophysics Data System (ADS)
Todokoro, Shigeru; Mukai, Yoshihiro
This paper introduces the present status of R & D on CAI teaching materials in Obunsha Co., Ltd. Characteristics of CAI using CD-ROM as well as Culture-in CAI Teaching Materials System for junior high school English are described. The system consists of CD-ROM driver XM-2000 and Pasopia 700 of Toshiba Corporation having both features of CD-ROM and FD. CD-ROM stores vast amount of voice data while FD does text and graphics data. It is a frame-oriented mode system enabling to raise learning effect.
Particulated articular cartilage: CAIS and DeNovo NT.
Farr, Jack; Cole, Brian J; Sherman, Seth; Karas, Vasili
2012-03-01
Cartilage Autograft Implantation System (CAIS; DePuy/Mitek, Raynham, MA) and DeNovo Natural Tissue (NT; ISTO, St. Louis, MO) are novel treatment options for focal articular cartilage defects in the knee. These methods involve the implantation of particulated articular cartilage from either autograft or juvenile allograft donor, respectively. In the laboratory and in animal models, both CAIS and DeNovo NT have demonstrated the ability of the transplanted cartilage cells to "escape" from the extracellular matrix, migrate, multiply, and form a new hyaline-like cartilage tissue matrix that integrates with the surrounding host tissue. In clinical practice, the technique for both CAIS and DeNovo NT is straightforward, requiring only a single surgery to affect cartilage repair. Clinical experience is limited, with short-term studies demonstrating both procedures to be safe, feasible, and effective, with improvements in subjective patient scores, and with magnetic resonance imaging evidence of good defect fill. While these treatment options appear promising, prospective randomized controlled studies are necessary to refine the indications and contraindications for both CAIS and DeNovo NT.
The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kelly, R.; Bolitho, M; Higgins, D
2009-01-01
Vibrio cholerae, the bacterium that causes the disease cholera, controls virulence factor production and biofilm development in response to two extracellular quorum-sensing molecules, called autoinducers. The strongest autoinducer, called CAI-1 (for cholera autoinducer-1), was previously identified as (S)-3-hydroxytridecan-4-one. Biosynthesis of CAI-1 requires the enzyme CqsA. Here, we determine the CqsA reaction mechanism, identify the CqsA substrates as (S)-2-aminobutyrate and decanoyl coenzyme A, and demonstrate that the product of the reaction is 3-aminotridecan-4-one, dubbed amino-CAI-1. CqsA produces amino-CAI-1 by a pyridoxal phosphate-dependent acyl-CoA transferase reaction. Amino-CAI-1 is converted to CAI-1 in a subsequent step via a CqsA-independent mechanism. Consistent with this,more » we find cells release {ge}100 times more CAI-1 than amino-CAI-1. Nonetheless, V. cholerae responds to amino-CAI-1 as well as CAI-1, whereas other CAI-1 variants do not elicit a quorum-sensing response. Thus, both CAI-1 and amino-CAI-1 have potential as lead molecules in the development of an anticholera treatment.« less
Structural basis of Na(+)-independent and cooperative substrate/product antiport in CaiT.
Schulze, Sabrina; Köster, Stefan; Geldmacher, Ulrike; Terwisscha van Scheltinga, Anke C; Kühlbrandt, Werner
2010-09-09
Transport of solutes across biological membranes is performed by specialized secondary transport proteins in the lipid bilayer, and is essential for life. Here we report the structures of the sodium-independent carnitine/butyrobetaine antiporter CaiT from Proteus mirabilis (PmCaiT) at 2.3-A and from Escherichia coli (EcCaiT) at 3.5-A resolution. CaiT belongs to the family of betaine/carnitine/choline transporters (BCCT), which are mostly Na(+) or H(+) dependent, whereas EcCaiT is Na(+) and H(+) independent. The three-dimensional architecture of CaiT resembles that of the Na(+)-dependent transporters LeuT and BetP, but in CaiT a methionine sulphur takes the place of the Na(+) ion to coordinate the substrate in the central transport site, accounting for Na(+)-independent transport. Both CaiT structures show the fully open, inward-facing conformation, and thus complete the set of functional states that describe the alternating access mechanism. EcCaiT contains two bound butyrobetaine substrate molecules, one in the central transport site, the other in an extracellular binding pocket. In the structure of PmCaiT, a tryptophan side chain occupies the transport site, and access to the extracellular site is blocked. Binding of both substrates to CaiT reconstituted into proteoliposomes is cooperative, with Hill coefficients up to 1.7, indicating that the extracellular site is regulatory. We propose a mechanism whereby the occupied regulatory site increases the binding affinity of the transport site and initiates substrate translocation.
Pflanz, Ralf; Voigt, Aaron; Yakulov, Toma; Jäckle, Herbert
2015-01-01
Tao-1, the single representative of the Sterile 20 kinase subfamily in Drosophila, is best known for destabilizing microtubules at the actin-rich cortex, regulating the cytoskeletal architecture of cells. More recently, Tao-1 was shown to act in the Salvador–Warts–Hippo pathway by phosphorylating Hippo, regulating cell growth as well as cell polarity. Here, we show that tao-1 encodes two proteins, one with the Sterile 20 kinase domain (Tao-L) and one without it (Tao-S), and that they act in an antagonistic manner. Tao-L expression causes lamellipodia-like cell protrusions, whereas Tao-S expression results in filopodia-like structures that make cells stick to the surface they attach to. Ectopic Tao-1 expression in the anterior region of Drosophila embryos results in pole cell formation as normally observed at the posterior end. Tao-S expression causes primordial germ cells (PGCs) to adhere to the inner wall of the gut primordia and prevents proper transepithelial migration to the gonads. Conversely, RNAi knockdowns of Tao-1 cause disordered migration of PGCs out of the gut epithelium, their dispersal within the embryo and cell death. The results reveal a novel function of Tao-1 in cell migration, which is based on antagonistic activities of two proteins encoded by a single gene. PMID:25589578
Two Generations of Sodic Metasomatism in an Allende Type B CAI
NASA Technical Reports Server (NTRS)
Ross, D. K.; Simon, J. I.; Simon, S. B.; Grossman, L.
2015-01-01
Calcium-Aluminum rich inclusions (CAI) in Allende, along with other chondritic compo-nents, experienced variable amounts and types of alter-ation of their mineralogy and chemistry. In CAIs, one of the principal types of alteration led to the depo-sition of nepheline and sodalite. Here we extend initial obervations of alteration in an Allende CAI, focus-ing on occurences of nepheline and a nepheline-like phase with unusally high Ca (referred to as "calcic nepheline" in this abstract). Detailed petrographic and microchemical observations of alteration phases in an Allende Type B CAI (TS4) show that two separate generations of "nepheline", with very distinct composi-tions, crystallized around the margins and in the interi-or of this CAI. We use observations of micro-faults as potential temporal markers, in order to place constraints on the timing of alteration events in Allende. These observa-tions of micro-faulting that truncate and offset one gen-eration of "nepheline" indicate that some "nepheline" crystallized before incorporation of the CAI into the Allende parent-body. Some of the sodic metasomatism in some Allende CAIs occurred prior to Allende par-ent-body assembly. The earlier generation of "calcic-nepheline" has a very distinctive, calcium-rich compo-sition, and the second generation is low in calcium, and matches the compositions of nephelines found in near-by altered chondrules, and in the Allende matrix.
Coordinated Oxygen Isotopic and Petrologic Studies of CAIS Record Varying Composition of Protosolar
NASA Technical Reports Server (NTRS)
Simon, Justin I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.
2012-01-01
Ca-, Al-rich inclusions (CAIs) record the O-isotope composition of Solar nebular gas from which they grew [1]. High spatial resolution O-isotope measurements afforded by ion microprobe analysis across the rims and margin of CAIs reveal systematic variations in (Delta)O-17 and suggest formation from a diversity of nebular environments [2-4]. This heterogeneity has been explained by isotopic mixing between the O-16-rich Solar reservoir [6] and a second O-16-poor reservoir (probably nebular gas) with a "planetary-like" isotopic composition [e.g., 1, 6-7], but the mechanism and location(s) where these events occur within the protoplanetary disk remain uncertain. The orientation of large and systematic variations in (Delta)O-17 reported by [3] for a compact Type A CAI from the Efremovka reduced CV3 chondrite differs dramatically from reports by [4] of a similar CAI, A37 from the Allende oxidized CV3 chondrite. Both studies conclude that CAIs were exposed to distinct, nebular O-isotope reservoirs, implying the transfer of CAIs among different settings within the protoplanetary disk [4]. To test this hypothesis further and the extent of intra-CAI O-isotopic variation, a pristine compact Type A CAI, Ef-1 from Efremovka, and a Type B2 CAI, TS4 from Allende were studied. Our new results are equally intriguing because, collectively, O-isotopic zoning patterns in the CAIs indicate a progressive and cyclic record. The results imply that CAIs were commonly exposed to multiple environments of distinct gas during their formation. Numerical models help constrain conditions and duration of these events.
Personality preference influences medical student use of specific computer-aided instruction (CAI)
McNulty, John A; Espiritu, Baltazar; Halsey, Martha; Mendez, Michelle
2006-01-01
Background The objective of this study was to test the hypothesis that personality preference, which can be related to learning style, influences individual utilization of CAI applications developed specifically for the undergraduate medical curriculum. Methods Personality preferences of students were obtained using the Myers-Briggs Type Indicator (MBTI) test. CAI utilization for individual students was collected from entry logs for two different web-based applications (a discussion forum and a tutorial) used in the basic science course on human anatomy. Individual login data were sorted by personality preference and the data statistically analyzed by 2-way mixed ANOVA and correlation. Results There was a wide discrepancy in the level and pattern of student use of both CAI. Although individual use of both CAI was positively correlated irrespective of MBTI preference, students with a "Sensing" preference tended to use both CAI applications more than the "iNtuitives". Differences in the level of use of these CAI applications (i.e., higher use of discussion forum vs. a tutorial) were also found for the "Perceiving/Judging" dimension. Conclusion We conclude that personality/learning preferences of individual students influence their use of CAI in the medical curriculum. PMID:16451719
CAI: Overcoming Attitude Barriers.
ERIC Educational Resources Information Center
Netusil, Anton J.; Kockler, Lois H.
During each of two school quarters, approximately 60 college students enrolled in a mathematics course were randomly assigned to an experimental group or a control group. The control group received instruction by the lecture method only; the experimental group received the same instruction, except that six computer-assisted instruction (CAI) units…
ERIC Educational Resources Information Center
Thompson, Richard A.
In a review of research on computer assisted instruction (CAI) related to reading, evidence collected provides tentative conclusions about CAI effectiveness. CAI was effective as an instructional medium in the surveyed studies. In a number of instances, CAI groups achieved higher scores than the control groups. Some studies indicated that CAI…
An Intelligent CAI Monitor and Generative Tutor. Final Report.
ERIC Educational Resources Information Center
Koffman, Elliot B.; Perry, James
This final report summarizes research findings and presents a model for generative computer assisted instruction (CAI) with respect to its usefulness in the classroom environment. Methods used to individualize instruction, and the evolution of a procedure used to select a concept for presentation to a student with the generative CAI system are…
Effectiveness of CAI Package on Achievement in Physics of IX Standard Students
ERIC Educational Resources Information Center
Maheswari, I. Uma; Ramakrishnan, N.
2015-01-01
The present study is an experimental one in nature, to find out the effectiveness of CAI package on in Physics of IX std. students. For this purpose a CAI package was developed and validated. The validated CAI package formed an independent variable of this study. The dependent variable is students' achievements in physics content. In order to find…
Search for 41K Excess in Efremovka CAIs
NASA Astrophysics Data System (ADS)
Srinivasan, G.; Ulyanov, A. A.; Goswami, J. N.
1993-07-01
We have used the ion microprobe to measure K isotopic composition of refractory phases in Efremovka CAIs to look for the possible presence of K excess from the decay of extinct radionuclide Ca (halflife = 0.13 Ma). The presence of Ca at the time of CAI formation, if established, will allow us to place a lower limit on the time interval between the last injection of freshly synthesized matter into the solar nebula and the formation of some of the first solid objects (CAIs) in the solar system. Several attempts have been made earlier to detect 41K excess in Allende CAIs [1-4]. We have further investigated this problem by analyzing the Efremovka CAIs for two reasons. First, both the petrographic and magnesium isotopic systematics suggest the Efremovka CAIs to be less altered compared to the Allende CAIs making them an ideal and perhaps better sample for this study. Second, the presence of large perovskite (~10 micrometers) allowed us to analyse this phase, which was not included in earlier studies. The major difficulty in accurately measuring 41K, which was identified in earlier studies, is the unresolvable (40Ca42Ca)++ interference, which was found to be matrix dependent [4]. In addition, one can also have interfernce from the (40CaH)+ peak. In our operating condition the interference from the hydride peak can be neglected (Fig. 1, which appears in the hard copy). We have analyzed terrestrial perovskite (K <= 20 ppm) to determine the (40Ca42Ca)++ correction term, and its equivalence with (40Ca43Ca)++ ion signal at mass 41.5 [4]. In perovskite, the (40Ca42Ca)++ signal constitutes ~80% of the signal at 41K and we could estimate this interference with confidence. A value of (2.7 +- 0.1) x 10^-5 was obtained for the ratio [(40Ca42Ca)++/42Ca+], which is similar to the measured [(40Ca43Ca)++/43Ca+] ratio of (2.4 +- 0.2) x 10^-5. We have therefore used the measured value for the latter ratio in the analyzed phases to correct for the doubly charged interference at mass 41
A ryanodine receptor-dependent Ca(i)(2+) asymmetry at Hensen's node mediates avian lateral identity.
Garic-Stankovic, Ana; Hernandez, Marcos; Flentke, George R; Zile, Maija H; Smith, Susan M
2008-10-01
In mouse, the establishment of left-right (LR) asymmetry requires intracellular calcium (Ca(i)(2+)) enrichment on the left of the node. The use of Ca(i)(2+) asymmetry by other vertebrates, and its origins and relationship to other laterality effectors are largely unknown. Additionally, the architecture of Hensen's node raises doubts as to whether Ca(i)(2+) asymmetry is a broadly conserved mechanism to achieve laterality. We report here that the avian embryo uses a left-side enriched Ca(i)(2+) asymmetry across Hensen's node to govern its lateral identity. Elevated Ca(i)(2+) was first detected along the anterior node at early HH4, and its emergence and left-side enrichment by HH5 required both ryanodine receptor (RyR) activity and extracellular calcium, implicating calcium-induced calcium release (CICR) as the novel source of the Ca(i)(2+). Targeted manipulation of node Ca(i)(2+) randomized heart laterality and affected nodal expression. Bifurcation of the Ca(i)(2+) field by the emerging prechordal plate may permit the independent regulation of LR Ca(i)(2+) levels. To the left of the node, RyR/CICR and H(+)V-ATPase activity sustained elevated Ca(i)(2+). On the right, Ca(i)(2+) levels were actively repressed through the activities of H(+)K(+) ATPase and serotonin-dependent signaling, thus identifying a novel mechanism for the known effects of serotonin on laterality. Vitamin A-deficient quail have a high incidence of situs inversus hearts and had a reversed calcium asymmetry. Thus, Ca(i)(2+) asymmetry across the node represents a more broadly conserved mechanism for laterality among amniotes than had been previously believed.
Desai, Apurva A; Innocenti, Federico; Janisch, Linda; DeMario, Mark; Shepard, Dale; Ramirez, Jacqueline; Fleming, Gini F; Ratain, Mark J
2004-11-01
Carboxyamidotriazole (CAI) is a novel antineoplastic agent in clinical development with limited oral bioavailability. In vitro, ketoconazole has been demonstrated to inhibit CYP3A4-mediated metabolism of CAI. We performed this phase I trial to determine if ketoconazole-mediated CYP3A4 inhibition would lead to favorable alteration of CAI pharmacokinetics, and to evaluate the safety, toxicity and tolerability of the proposed combination. Forty-seven patients were treated using a standard three patients per cohort CAI dose-escalation scheme. In cycle 1, CAI was administered alone on day-6 followed by a single dose of ketoconazole (200 mg) on day 0. CAI and ketoconazole (200 mg/day) were subsequently coadministered on days 1 and 3-28. Plasma samples for pharmacokinetic analysis were obtained following the doses on days-6 and 1. All subsequent cycles were of 28-day duration, and consisted of daily CAI and ketoconazole coadministration. Pharmacokinetic analysis was performed on samples from 44 patients. In most patients administration of ketoconazole produced an increase in CAI AUC and Cmax with a decrease in CAI clearance. Seven patients experienced stable disease for up to 12 months. Gastrointestinal and constitutional toxicities were the most common toxicities. Coadministration of CAI with ketoconazole increased CAI exposure in most of the patients without altering the toxicity profile of CAI. The highest CAI dose administered on the trial was 300 mg/day. The clinical utility of such a modulation strategy might be explored in future clinical trials of CAI.
Experimental Determination of Li, Be and B Partitioning During CAI Crystallization
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ryerson, F J; Brenan, J M; Phinney, D L
2005-01-12
The main focus of the work is to develop a better understanding of the distribution of the elements B, Be and Li in melilite, fassaitic clinop clinopy-roxene, anorthite and spinel, which are the primary constituents of calcium-aluminum-rich inclusions (CAIs). These elements are the parent or decay products of short-lived nuclides (specifically, {sup 7}Be and {sup 10}Be) formed by cosmic ray spallation reactions on silicon and oxygen. Recent observations suggest that some CAIs contain ''fossil'' {sup 7}Be and {sup 10}Be in the form of ''excess'' amounts of their decay products (B and Li). The exact timing of {sup 7}Be and {supmore » 10}Be production is unknown, but if it occurred early in CAI history, it could constrain the birthplace of CAIs to be within a limited region near the infant sun. Other interpretations are possible, however, and bear little significance to early CAI genesis. In order to interpret the anomalies as being ''primary'', and thus originating at high temperature, information on the intermineral partitioning of both parent and daughter elements is required.« less
Effect of CAI on Achievement of LD Students in English
ERIC Educational Resources Information Center
Sivaram, R. T.; Ramar, R.
2014-01-01
The present experimental study was undertaken with three objectives in view, (i) to identify students with language learning disabilities (ii) to develop CAI software to teach LD students through computer-assisted instruction and (iii) to measure the effectiveness of CAI with special reference to LD students. Two matched groups of LD students were…
An Object-Oriented Architecture for a Web-Based CAI System.
ERIC Educational Resources Information Center
Nakabayashi, Kiyoshi; Hoshide, Takahide; Seshimo, Hitoshi; Fukuhara, Yoshimi
This paper describes the design and implementation of an object-oriented World Wide Web-based CAI (Computer-Assisted Instruction) system. The goal of the design is to provide a flexible CAI/ITS (Intelligent Tutoring System) framework with full extendibility and reusability, as well as to exploit Web-based software technologies such as JAVA, ASP (a…
CAI-BASIC: A Program to Teach the Programming Language BASIC.
ERIC Educational Resources Information Center
Barry, Thomas Anthony
A computer-assisted instruction (CAI) program was designed which fulfills the objectives of teaching a simple programing language, interpreting student responses, and executing and editing student programs. The CAI-BASIC program is written in FORTRAN IV and executes on IBM-2741 terminals while running under a time-sharing system on an IBM-360-70…
Oxygen isotope variations at the margin of a CAI records circulation within the solar nebula.
Simon, Justin I; Hutcheon, Ian D; Simon, Steven B; Matzel, Jennifer E P; Ramon, Erick C; Weber, Peter K; Grossman, Lawrence; DePaolo, Donald J
2011-03-04
Micrometer-scale analyses of a calcium-, aluminum-rich inclusion (CAI) and the characteristic mineral bands mantling the CAI reveal that the outer parts of this primitive object have a large range of oxygen isotope compositions. The variations are systematic; the relative abundance of (16)O first decreases toward the CAI margin, approaching a planetary-like isotopic composition, then shifts to extremely (16)O-rich compositions through the surrounding rim. The variability implies that CAIs probably formed from several oxygen reservoirs. The observations support early and short-lived fluctuations of the environment in which CAIs formed, either because of transport of the CAIs themselves to distinct regions of the solar nebula or because of varying gas composition near the proto-Sun.
The cultural and ecological impacts of aboriginal tourism: a case study on Taiwan's Tao tribe.
Liu, Tzu-Ming; Lu, Dau-Jye
2014-01-01
We show that tourism activities severely impact the ecology of Orchid Island, its natural resources, and the culture of the Tao tribe. For example, highway widening, in response to the increased traffic volumes caused by tourism, required many Pandanus trees to be cut and removed, which has placed the coconut crabs in danger of extinction. To promote eco-tourism, observation trips to observe Elegant Scops owls and Birdwing butterflies have taken place, which has affected the breeding of these two protected species. The Elegant Scops owls- and Birdwing butterflies-related tourism activities also break the "evil spirits" taboo of the Tao people and have caused the disappearance of the specifications for using traditional natural resources, causing natural ecosystems to face the threat of excessive use. In addition to promoting and advocating aboriginal tourism of the Tao people on Orchid Island, the Taiwanese government should help the Tao people to develop a management model that combines traditional regulations and tourism activities.
Microstructural Investigation of a Wark-Lovering Rim on a Vigarano CAI
NASA Technical Reports Server (NTRS)
Han, J.; Keller, L. P.; Needham, A. W.; Messenger, S.; Simon, J. I.
2015-01-01
Wark-Lovering (WL) rims are thin multi-layered mineral sequences that surround many CAIs. These rim layers consist of the primary minerals found in the CAI interiors, but vary in their mineralogy. Several models for their origin have been proposed including condensation, reaction with a nebular gas, evaporation, or combinations of these. However, there still is little consensus on how and when the rims formed. Here, we describe the microstructure and mineralogy of a WL rim on a type B CAI from the Vigarano CV(sub red) chondrite using FIB/TEM to better understand the astrophysical significance of WL rim formation.
CAI in Advanced Literature Class.
ERIC Educational Resources Information Center
Hinton, Norman
1981-01-01
Ways that computer assisted instruction (CAI) can be useful in teaching English at upperclass and graduate levels are considered, with illustrations from PLATO lessons that have been composed and programmed. One lesson takes advantage of PLATO's graphic design capabilities, which enabled the teacher to design the runic figures and to show them in…
The Making of a National Hero: Tao Xingzhi's Legacies in the People's Republic of China
ERIC Educational Resources Information Center
Yao, Yusheng
2002-01-01
Tao Xingzhi (1891-1946) was an outstanding modern educator, whose theory and practice of life education represented a radical discourse in the Chinese debate on modern education and national reconstruction. Although he is most often known as a Deweyan reformer in the mainstream of American studies, in his theoretical maturity Tao can more…
Feasibility study of Fe3O4/TaO x nanoparticles as a radiosensitizer for proton therapy
NASA Astrophysics Data System (ADS)
Ahn, Sang Hee; Lee, Nohyun; Choi, Changhoon; Shin, Sung Won; Han, Youngyih; Park, Hee Chul
2018-06-01
We investigated the feasibility of using multifunctional Fe3O4/TaO x (core/shell) nanoparticles, developed for use in contrast agents for computed tomography (CT) and magnetic resonance imaging (MRI), as dose-enhancing radiosensitizers. First, to verify the detectability of Fe3O4/TaO x nanoparticles in imaging, in vivo tests were conducted. Approximately 600 mg kg‑1 of 19 nm-diameter Fe3O4/TaO x nanoparticles dispersed in phosphate-buffered saline was injected into the tail vein of six Balb/c mice used as tumour (4T1 mammary carcinoma cell) models. Three mice underwent MRI (BioSpec 70/20 USR, Bruker, Billerica, MA, USA) and micro-CT (Inveon, Siemens Preclinical, Knoxville, TN, USA) before and after the injection. The difference between the pre- and post-injection images was quantified by finding the correlation coefficient. The aorta, blood vessel, and liver were clearly seen in the MRI and micro-CT images 60 min after intravenous injection of Fe3O4/TaO x nanoparticles, but the tumour region was not visible in the CT images until after 24 h. There were large differences between the pre- and post-injection images. Second, the therapeutic enhancement dose of nanomaterials was computed via Monte Carlo simulation. Monoenergetic 70- and 150 MeV proton beams irradiated x-ray contrast agent (iodine, BaSO4), MRI contrast agent (gadolinium, Fe3O4), Au, Fe3O4/TaO x (core/shell) nanoparticles and water located at the centre of a 4 × 4 × 4 µm3 water phantom, upon which the dose enhancement ratio (DER) (dose with/without nanoparticles) was computed. When 70 MeV protons irradiated the Au, gadolinium, Fe3O4/TaO x , Fe3O4, iodine, and BaSO4 nanoparticles, the DERs at 1 nm were 15.76, 7.68, 7.82, 6.17, 4.85, and 5.51, respectively. Fe3O4/TaO x nanoparticles have the potential to be used as a multifunctional agent that enhances tumour detection and increases the dose. Dose enhancement with Fe3O4/TaO x was half that with Au. However, Fe3O4/TaO x is
NASA Astrophysics Data System (ADS)
Kööp, Levke; Nakashima, Daisuke; Heck, Philipp R.; Kita, Noriko T.; Tenner, Travis J.; Krot, Alexander N.; Nagashima, Kazuhide; Park, Changkun; Davis, Andrew M.
2018-01-01
Calcium-aluminum-rich inclusions (CAIs) are the oldest dated objects that formed inside the Solar System. Among these are rare, enigmatic objects with large mass-dependent fractionation effects (F CAIs), which sometimes also have large nucleosynthetic anomalies and a low initial abundance of the short-lived radionuclide 26Al (FUN CAIs). We have studied seven refractory hibonite-rich CAIs and one grossite-rich CAI from the Murchison (CM2) meteorite for their oxygen, calcium, and titanium isotopic compositions. The 26Al-26Mg system was also studied in seven of these CAIs. We found mass-dependent heavy isotope enrichment in all measured elements, but never simultaneously in the same CAI. The data are hard to reconcile with a single-stage melt evaporation origin and may require reintroduction or reequilibration for magnesium, oxygen and titanium after evaporation for some of the studied CAIs. The initial 26Al/27Al ratios inferred from model isochrons span a range from <1 × 10-6 to canonical (∼5 × 10-5). The CAIs show a mutual exclusivity relationship between inferred incorporation of live 26Al and the presence of resolvable anomalies in 48Ca and 50Ti. Furthermore, a relationship exists between 26Al incorporation and Δ17O in the hibonite-rich CAIs (i.e., 26Al-free CAIs have resolved variations in Δ17O, while CAIs with resolved 26Mg excesses have Δ17O values close to -23‰). Only the grossite-rich CAI has a relatively enhanced Δ17O value (∼-17‰) in spite of a near-canonical 26Al/27Al. We interpret these data as indicating that fractionated hibonite-rich CAIs formed over an extended time period and sampled multiple stages in the isotopic evolution of the solar nebula, including: (1) an 26Al-poor nebula with large positive and negative anomalies in 48Ca and 50Ti and variable Δ17O; (2) a stage of 26Al-admixture, during which anomalies in 48Ca and 50Ti had been largely diluted and a Δ17O value of ∼-23‰ had been achieved in the CAI formation region; and (3
Closed system oxygen isotope redistribution in igneous CAIs upon spinel dissolution
NASA Astrophysics Data System (ADS)
Aléon, Jérôme
2018-01-01
In several Calcium-Aluminum-rich Inclusions (CAIs) from the CV3 chondrites Allende and Efremovka, representative of the most common igneous CAI types (type A, type B and Fractionated with Unknown Nuclear isotopic anomalies, FUN), the relationship between 16O-excesses and TiO2 content in pyroxene indicates that the latter commonly begins to crystallize with a near-terrestrial 16O-poor composition and becomes 16O-enriched during crystallization, reaching a near-solar composition. Mass balance calculations were performed to investigate the contribution of spinel to this 16O-enrichment. It is found that a back-reaction of early-crystallized 16O-rich spinel with a silicate partial melt having undergone a 16O-depletion is consistent with the O isotopic evolution of CAI minerals during magmatic crystallization. Dissolution of spinel explains the O isotopic composition (16O-excess and extent of mass fractionation) of pyroxene as well as that of primary anorthite/dmisteinbergite and possibly that of the last melilite crystallizing immediately before pyroxene. It requires that igneous CAIs behaved as closed-systems relative to oxygen from nebular gas during a significant fraction of their cooling history, contrary to the common assumption that CAI partial melts constantly equilibrated with gas. The mineralogical control on O isotopes in igneous CAIs is thus simply explained by a single 16O-depletion during magmatic crystallization. This 16O-depletion occurred in an early stage of the thermal history, after the crystallization of spinel, i.e. in the temperature range for melilite crystallization/partial melting and did not require multiple, complex or late isotope exchange. More experimental work is however required to deduce the protoplanetary disk conditions associated with this 16O-depletion.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-24
... Mexico. FOR FURTHER INFORMATION CONTACT: Brad Higdon, Planning and Environmental Coordinator, Taos Field..., largely through the public participation provided under NEPA. The Draft RMP/ Environmental Impact...] Notice of Availability of the Record of Decision for the Taos Resource Management Plan/Environmental...
Ventura, Joseph; Subotnik, Kenneth L; Ered, Arielle; Hellemann, Gerhard S; Nuechterlein, Keith H
2016-04-01
Progress has been made in developing interview-based measures for the assessment of cognitive functioning, such as the Cognitive Assessment Interview (CAI), as co-primary measures that compliment objective neurocognitive assessments and daily functioning. However, a few questions remain, including whether the relationships with objective cognitive measures and daily functioning are high enough to justify the CAI as an co-primary measure and whether patient-only assessments are valid. Participants were first-episode schizophrenia patients (n=60) and demographically-similar healthy controls (n=35), chronic schizophrenia patients (n=38) and demographically similar healthy controls (n=19). Participants were assessed at baseline with an interview-based measure of cognitive functioning (CAI), a test of objective cognitive functioning, functional capacity, and role functioning at baseline, and in the first episode patients again 6 months later (n=28). CAI ratings were correlated with objective cognitive functioning, functional capacity, and functional outcomes in first-episode schizophrenia patients at similar magnitudes as in chronic patients. Comparisons of first-episode and chronic patients with healthy controls indicated that the CAI sensitively detected deficits in schizophrenia. The relationship of CAI Patient-Only ratings with objective cognitive functioning, functional capacity, and daily functioning were comparable to CAI Rater scores that included informant information. These results confirm in an independent sample the relationship of the CAI ratings with objectively measured cognition, functional capacity, and role functioning. Comparison of schizophrenia patients with healthy controls further validates the CAI as an co-primary measure of cognitive deficits. Also, CAI change scores were strongly related to objective cognitive change indicating sensitivity to change. Copyright © 2016 Elsevier B.V. All rights reserved.
Bauer, Paul W.; Kelson, Keith I.; Grauch, V.J.S.; Drenth, Benjamin J.; Johnson, Peggy S.; Aby, Scott B.; Felix, Brigitte
2016-01-01
The southern Taos Valley encompasses the physiographic and geologic transition zone between the Picuris Mountains and the San Luis Basin of the Rio Grande rift. The Embudo fault zone is the rift transfer structure that has accommodated the kinematic disparities between the San Luis Basin and the Española Basin during Neogene rift extension. The eastern terminus of the transfer zone coincides with the intersection of four major fault zones (Embudo, Sangre de Cristo, Los Cordovas, and Picuris-Pecos), resulting in an area of extreme geologic and hydrogeologic complexities in both the basin-fill deposits and the bedrock. Although sections of the Embudo fault zone are locally exposed in the bedrock of the Picuris Mountains and in the late Cenozoic sedimentary units along the top of the Picuris piedmont, the full proportions of the fault zone have remained elusive due to a pervasive cover of Quaternary surficial deposits. We combined insights derived from the latest geologic mapping of the area with deep borehole data and high-resolution aeromagnetic and gravity models to develop a detailed stratigraphic/structural model of the rift basin in the southern Taos Valley area. The four fault systems in the study area overlap in various ways in time and space. Our geologic model states that the Picuris-Pecos fault system exists in the basement rocks (Picuris formation and older units) of the rift, where it is progressively down dropped and offset to the west by each Embudo fault strand between the Picuris Mountains and the Rio Pueblo de Taos. In this model, the Miranda graben exists in the subsurface as a series of offset basement blocks between the Ponce de Leon neighborhood and the Rio Pueblo de Taos. In the study area, the Embudo faults are pervasive structures between the Picuris Mountains and the Rio Pueblo de Taos, affecting all geologic units that are older than the Quaternary surficial deposits. The Los Cordovas faults are thought to represent the late Tertiary to
NASA Technical Reports Server (NTRS)
Joswiak, D. J.; Brownlee, D. E.; Nguyen, A. N.; Messenger, S
2017-01-01
Examination of >200 comet Wild 2 particles collected by the Stardust (SD) mission shows that the CAI abundance of comet Wild 2's rocky material is near 1% and that nearly 50% of all bulbous tracks will contain at least one recognizable CAI fragment. A similar abundance to Wild 2 is found in a giant cluster IDP thought to be of cometary origin. The properties of these CAIs and their comparison with meteoritic CAIs provide important clues on the role of CAIs in the early Solar System (SS) and how they were transported to the edge of the solar nebula where Kuiper Belt comets formed. Previously, only two CAIs in comet Wild 2 had been identified and studied in detail. Here we present 2 new Wild 2 CAIs and 2 from a giant cluster cometary IDP, describe their mineralogical characteristics and show that they are most analogous to nodules in spinel-rich, fine-grained inclusions (FGIs) observed in CV3 and other chondrites. Additionally, we present new O isotope measurements from one CAI from comet Wild 2 and show that its oxygen isotopic composition is similar to some FGIs. This is only the second CAI from Wild 2 in which O isotopes have been measured.
Silicon Isotopic Fractionation of CAI-like Vacuum Evaporation Residues
DOE Office of Scientific and Technical Information (OSTI.GOV)
Knight, K; Kita, N; Mendybaev, R
2009-06-18
Calcium-, aluminum-rich inclusions (CAIs) are often enriched in the heavy isotopes of magnesium and silicon relative to bulk solar system materials. It is likely that these isotopic enrichments resulted from evaporative mass loss of magnesium and silicon from early solar system condensates while they were molten during one or more high-temperature reheating events. Quantitative interpretation of these enrichments requires laboratory determinations of the evaporation kinetics and associated isotopic fractionation effects for these elements. The experimental data for the kinetics of evaporation of magnesium and silicon and the evaporative isotopic fractionation of magnesium is reasonably complete for Type B CAI liquidsmore » (Richter et al., 2002, 2007a). However, the isotopic fractionation factor for silicon evaporating from such liquids has not been as extensively studied. Here we report new ion microprobe silicon isotopic measurements of residual glass from partial evaporation of Type B CAI liquids into vacuum. The silicon isotopic fractionation is reported as a kinetic fractionation factor, {alpha}{sub Si}, corresponding to the ratio of the silicon isotopic composition of the evaporation flux to that of the residual silicate liquid. For CAI-like melts, we find that {alpha}{sub Si} = 0.98985 {+-} 0.00044 (2{sigma}) for {sup 29}Si/{sup 28}Si with no resolvable variation with temperature over the temperature range of the experiments, 1600-1900 C. This value is different from what has been reported for evaporation of liquid Mg{sub 2}SiO{sub 4} (Davis et al., 1990) and of a melt with CI chondritic proportions of the major elements (Wang et al., 2001). There appears to be some compositional control on {alpha}{sub Si}, whereas no compositional effects have been reported for {alpha}{sub Mg}. We use the values of {alpha}Si and {alpha}Mg, to calculate the chemical compositions of the unevaporated precursors of a number of isotopically fractionated CAIs from CV chondrites
Micro-CAI in Education: Some Considerations.
ERIC Educational Resources Information Center
Majsterek, David
This paper focuses on the applications which best suit the microcomputer in an educational setting with emphasis on adapting effective pedagogical practice to the computer's programability and delivery capabilities. Discovery learning and "being told" are identified as two types of computer assisted instruction (CAI) and sample uses of…
CAI System with Multi-Media Text Through Web Browser for NC Lathe Programming
NASA Astrophysics Data System (ADS)
Mizugaki, Yoshio; Kikkawa, Koichi; Mizui, Masahiko; Kamijo, Keisuke
A new Computer Aided Instruction (CAI) system for NC lathe programming has been developed with use of multi-media texts including movies, animations, pictures, sound and texts through Web browser. Although many CAI systems developed previously for NC programming consist of text-based instructions, it is difficult for beginners to learn NC programming with use of them. In the developed CAI system, multi-media texts are adopted for the help of users' understanding, and it is available through Web browser anytime and anywhere. Also the error log is automatically recorded for the future references. According to the NC programming coded by a user, the movement of the NC lathe is animated and shown in the monitor screen in front of the user. If its movement causes the collision between a cutting tool and the lathe, some sound and the caution remark are generated. If the user makes mistakes some times at a certain stage in learning NC, the corresponding suggestion is shown in the form of movies, animations, and so forth. By using the multimedia texts, users' attention is kept concentrated during a training course. In this paper, the configuration of the CAI system is explained and the actual procedures for users to learn the NC programming are also explained too. Some beginners tested this CAI system and their results are illustrated and discussed from the viewpoint of the efficiency and usefulness of this CAI system. A brief conclusion is also mentioned.
Chronology of chrondrule and CAI formation: Mg-Al isotopic evidence
NASA Technical Reports Server (NTRS)
Macpherson, G. J.; Davis, A. M.
1994-01-01
Details of the chondrule and Ca-Al-rich inclusion (CAI) formation during the earliest history of the solar system are imperfectly known. Because CAI's are more 'refractory' than ferromagnesian chondrules and have the lowest recorded initial Sr-87/Sr-86 ratios of any solar system materials, the expectation is that CAI's formed earlier than chondrules. But it is not known, for example, if CAI formation had stopped by the time chondrule formation began. Conventional (absolute) age-dating techniques cannot adequately resolve small age differences (less than 10(exp 6) years) between objects of such antiquity. One approach has been to look at systematic differences in the daughter products of short-lived radionuclides such as Al-26 and I-129. Unfortunately, neither system appears to be 'well-behaved.' One possible reason for this circumstance is that later secondary events have partially reset the isotopic systems, but a viable alternative continues to be large-scale (nebular) heterogeneity in initial isotopic abundances, which would of course render the systems nearly useless as chronometers. In the past two years the nature of this problem has been redefined somewhat. Examination of the Al-Mg isotopic database for all CAI's suggests that the vast majority of inclusions originally had the same initial Al-26/Al-27 abundance ratio, and that the ill-behaved isotopic systematics now observed are the results of later partial reequilibration due to thermal processing. Isotopic heterogeneities did exist in the nebula, as demonstrated by the existence of so-called FUN inclusions in CV3 chondrites and isotopically anomalous hibonite grains in CM2 chondrites, which had little or no live Al-26 at the time of their formation. But, among the population of CV3 inclusions at least, FUN inclusions appear to have been a relatively minor nebular component.
Individual Differences in Learner Controlled CAI.
ERIC Educational Resources Information Center
Judd, Wilson A.; And Others
Two assumptions in support of learner-controlled computer-assisted instruction (CAI) are that (1) instruction administered under learner control will be less aversive than if administered under program control, and (2) the student is sufficiently aware of his learning state to make, in most instances, his own instructional decisions. Some 130…
INAA of CAIs from the Maralinga CK4 chondrite: Effects of parent body thermal metamorphism
NASA Technical Reports Server (NTRS)
Lindstrom, D. J.; Keller, L. P.; Martinez, R. R.
1993-01-01
Maralinga is an anomalous CK4 carbonaceous chondrite which contains numerous Ca-, Al-rich inclusions (CAI's) unlike the other members of the CK group. These CAI's are characterized by abundant green hercynitic spinel intergrown with plagioclase and high-Ca clinopyroxene, and a total lack of melilite. Instrumental Neutron Activation Analysis (INAA) was used to further characterize the meteorite, with special focus on the CAI's. High sensitivity INAA was done on eight sample disks about 100-150 microns in diameter obtained from a normal 30 micron thin section with a diamond microcoring device. The CAI's are enriched by 60-70X bulk meteorite values in Zn, suggesting that the substantial exchange of Fe for Mg that made the spinel in the CAI's hercynitic also allowed efficient scavenging of Zn from the rest of the meteorite during parent body thermal metamorphism. Less mobile elements appear to have maintained their initial heterogeneity.
The Tao survivorship of schistosomes: implications for schistosomiasis control.
Cai, Pengfei; Gobert, Geoffrey N; You, Hong; McManus, Donald P
2016-06-01
Schistosomiasis, caused by blood flukes of the genus Schistosoma, is a major public health problem which contributes substantially to the economic and financial burdens of many nations in the developing world. An array of survival strategies, such as the unique structure of the tegument which acts as a major host-parasite interface, immune modulation mechanisms, gene regulation, and apoptosis and self-renewal have been adopted by schistosome parasites over the course of long-term evolution with their mammalian definitive hosts. Recent generation of complete schistosome genomes together with numerous biological, immunological, high-throughput "-omics" and gene function studies have revealed the Tao or strategies that schistosomes employ not only to promote long-term survival, but also to ensure effective life cycle transmission. New scenarios for the future control of this important neglected tropical disease will present themselves as our understanding of these Tao increases. Copyright © 2016 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
Status of the Transneptunian Automated Occultation Survey (TAOS II)
NASA Astrophysics Data System (ADS)
Lehner, Matthew; Wang, Shiang-Yu; Reyes-Ruiz, Mauricio; Alcock, Charles; Castro Chacón, Joel; Chen, Wen-Ping; Chu, You-Hua; Cook, Kem H.; Figueroa, Liliana; Geary, John C.; Hernandez, Benjamin; Huang, Chung-Kai; Norton, Timothy; Szentgyorgyi, Andrew; Yen, Wei-Ling; Zhang, Zhi-Wei
2017-10-01
The Transneptunian Automated Occultation Survey (TAOS II) will aim to detect occultations of stars by small (~1 km diameter) objects in the Kuiper Belt and beyond. Such events are very rare (<0.001 events per star per year) and short in duration (~200 ms), so many stars must be monitored at a high readout cadence. TAOS II will operate three 1.3 meter telescopes at the Observatorio Astronómico Nacional at San Pedro Mártir in Baja California, México. With a 2.3 square degree field of view and a high speed camera comprising CMOS imagers, the survey will monitor 10,000 stars simultaneously with all three telescopes at a readout cadence of 20 Hz. Construction of the site began in the fall of 2013 and was completed this summer. Telescope installation began in August 2017. This poster will provide an update on the status of the survey development and the schedule leading to the beginning of survey operations.
NASA Astrophysics Data System (ADS)
Oishi, Yu; Ishida, Haruma; Nakajima, Takashi Y.; Nakamura, Ryosuke; Matsunaga, Tsuneo
2018-05-01
The Greenhouse Gases Observing Satellite (GOSAT) was launched in 2009 to measure global atmospheric CO2 and CH4 concentrations. GOSAT is equipped with two sensors: the Thermal And Near infrared Sensor for carbon Observations (TANSO)-Fourier transform spectrometer (FTS) and TANSO-Cloud and Aerosol Imager (CAI). The presence of clouds in the instantaneous field of view of the FTS leads to incorrect estimates of the concentrations. Thus, the FTS data suspected to have cloud contamination must be identified by a CAI cloud discrimination algorithm and rejected. Conversely, overestimating clouds reduces the amount of FTS data that can be used to estimate greenhouse gas concentrations. This is a serious problem in tropical rainforest regions, such as the Amazon, where the amount of useable FTS data is small because of cloud cover. Preparations are continuing for the launch of the GOSAT-2 in fiscal year 2018. To improve the accuracy of the estimates of greenhouse gases concentrations, we need to refine the existing CAI cloud discrimination algorithm: Cloud and Aerosol Unbiased Decision Intellectual Algorithm (CLAUDIA1). A new cloud discrimination algorithm using a support vector machine (CLAUDIA3) was developed and presented in another paper. Although the use of visual inspection of clouds as a standard for judging is not practical for screening a full satellite data set, it has the advantage of allowing for locally optimized thresholds, while CLAUDIA1 and -3 use common global thresholds. Thus, the accuracy of visual inspection is better than that of these algorithms in most regions, with the exception of snow- and ice-covered surfaces, where there is not enough spectral contrast to identify cloud. In other words, visual inspection results can be used as truth data for accuracy evaluation of CLAUDIA1 and -3. For this reason visual inspection can be used for the truth metric for the cloud discrimination verification exercise. In this study, we compared CLAUDIA1-CAI and
Compound ultrarefractory CAI-bearing inclusions from CV3 carbonaceous chondrites
NASA Astrophysics Data System (ADS)
Ivanova, Marina A.; Krot, Alexander N.; Nagashima, Kazuhide; MacPherson, Glenn J.
2012-12-01
NWA10758: A New CV3 Chondrite Bearing a Giant CAI with Hibonite-Rich Wark-Lovering Rim
NASA Technical Reports Server (NTRS)
Ross, D. K.; Simon, J. I.; Zolensky, M.
2017-01-01
Northwest Africa (NWA) 10758 is a newly identified carbonaceous chondrite that is a Bali-like oxidized CV3. The large Ca-Al rich inclusion (CAI) in this sample is approx. 2.4 x 1.4 cm. The CAI is transitional in composition between type A and type B, with interior mineralogy dominated by melilite, plus less abundant spinel and Al-Ti rich diopside, and only very minor anorthite (Fig. 1A). This CAI is largely free of secondary alteration in the exposed section we examined, with almost no nepheline, sodalite or Ca-Fe silicates. The Wark-Lovering (WL) rim on this CAI is dominated by hibonite, with lower abundances of spinel and perovskite, and with hibonite locally overlain by melilite plus perovskite (as in Fig. 1B). Note that the example shown in 1B is exceptional. Around most of the CAI, hibonite + spinel + perovskite form the WL rim, without overlying melilite. The WL rim can be unusually thick, ranging from approx. 20 microns up to approx. 150 microns. A well-developed, stratified accretionary rim infills embayments of the CAI, and thins over protuberances in the convoluted CAI surface.
Sustaining a Moored Ocean Observing System in the Tropical Pacific: The Evolution of the TAO Array
NASA Astrophysics Data System (ADS)
Grissom, K.; Kessler, W. S.; McArthur, S.
2016-12-01
The Tropical Atmosphere Ocean (TAO) array has been a major observational component of El Niño Southern Oscillation (ENSO) research and operational climate forecasting since its conception in 1984. Developed by NOAA's Pacific Marine Environmental Laboratory (PMEL) in response to the poorly-observed 1982-1983 El Niño, the moored buoy array was completed in 1994 and transitioned from PMEL to NOAA's National Data Buoy Center (NDBC) in 2005. During this transition, the TAO Refresh project was initiated to address equipment obsolescence and the need for more real-time data. Completed in 2011, the "TAO Refresh" array has new capabilities and added value. Then in 2012, federal resource shortfalls threatened the future sustainability of this array. The resulting limited maintenance caused a decline in real-time data, yet it also served as the impetus to focus international attention on the demands of sustaining an observing system capable of monitoring the tropical ocean-atmosphere interaction. To continue collecting observations at historical levels, NOAA and partners needed an alternate strategy, and to this end conceived the international TPOS 2020 project, the Tropical Pacific Observing System for 2020. At more than 30 years, the TAO array stands as one of the longest sustained in-situ ocean observing networks in the world and provides a rare long-term record of a dominant climate signal. Here we review the evolution of the TAO array, from its development at PMEL, to its transition and modernization at NDBC, and provide a preview of its future as a key element of the Tropical Pacific Observing System.
CaiT of Escherichia coli, a new transporter catalyzing L-carnitine/gamma -butyrobetaine exchange.
Jung, Heinrich; Buchholz, Marion; Clausen, Jurgen; Nietschke, Monika; Revermann, Anne; Schmid, Roland; Jung, Kirsten
2002-10-18
l-Carnitine is essential for beta-oxidation of fatty acids in mitochondria. Bacterial metabolic pathways are used for the production of this medically important compound. Here, we report the first detailed functional characterization of the caiT gene product, a putative transport protein whose function is required for l-carnitine conversion in Escherichia coli. The caiT gene was overexpressed in E. coli, and the gene product was purified by affinity chromatography and reconstituted into proteoliposomes. Functional analyses with intact cells and proteoliposomes demonstrated that CaiT is able to catalyze the exchange of l-carnitine for gamma-butyrobetaine, the excreted end product of l-carnitine conversion in E. coli, and related betaines. Electrochemical ion gradients did not significantly stimulate l-carnitine uptake. Analysis of l-carnitine counterflow yielded an apparent external K(m) of 105 microm and a turnover number of 5.5 s(-1). Contrary to related proteins, CaiT activity was not modulated by osmotic stress. l-Carnitine binding to CaiT increased the protein fluorescence and caused a red shift in the emission maximum, an observation explained by ligand-induced conformational alterations. The fluorescence effect was specific for betaine structures, for which the distance between trimethylammonium and carboxyl groups proved to be crucial for affinity. Taken together, the results suggest that CaiT functions as an exchanger (antiporter) for l-carnitine and gamma-butyrobetaine according to the substrate/product antiport principle.
NASA Astrophysics Data System (ADS)
Wu, Peng; Hu, Ming Yu; Chong, Xiao Yu; Feng, Jing
2018-03-01
Using the solid-state reaction method, the (ZrO2)x-(Dy3TaO7)1-x (x = 0, 0.02, 0.04, 0.06, 0.08, and 0.1) ceramics are synthesized in this work. The identification of the crystal structures indicates that the (ZrO2)x-(Dy3TaO7)1-x ceramics belong to the orthorhombic system, and the space group is C2221 in spite of the value of x increasing to 0.1. The thermal conductivities of the (ZrO2)x-(Dy3TaO7)1-x ceramics range from 1.3 W/(m K) to 1.8 W/(m K), and this value is much lower than that of 7-8 YSZ (yttria-stabilized zirconia). Besides, the (ZrO2)x-(Dy3TaO7)1-x ceramics possess the glass-like thermal conductivity caused by intrinsic oxygen vacancies existing in the lattice of Dy3TaO7. Moreover, the results of thermal expansion rates demonstrate that the (ZrO2)x-(Dy3TaO7)1-x ceramics possess excellent high temperature phase stability, and the thermal expansion coefficients [(9.7-11) × 10-6 K-1] are comparable to that of 7-8 YSZ.
NASA Technical Reports Server (NTRS)
Ross, D. K.; Simon, J. I.; Simon, S. B.; Grossman, L.
2012-01-01
Ca-Fe and alkali-halide alteration of CAIs is often attributed to aqueous alteration by fluids circulating on asteroidal parent bodies after the various chondritic components have been assembled, although debate continues about the roles of asteroidal vs. nebular modification processes [1-7]. Here we report de-tailed observations of alteration products in a large Type B2 CAI, TS4 from Allende, one of the oxidized subgroup of CV3s, and propose a speculative model for aqueous alteration of CAIs in a nebular setting. Ca-Fe alteration in this CAI consists predominantly of end-member hedenbergite, end-member andradite, and compositionally variable, magnesian high-Ca pyroxene. These phases are strongly concentrated in an unusual "nodule" enclosed within the interior of the CAI (Fig. 1). The Ca, Fe-rich nodule superficially resembles a clast that pre-dated and was engulfed by the CAI, but closer inspection shows that relic spinel grains are enclosed in the nodule, and corroded CAI primary phases interfinger with the Fe-rich phases at the nodule s margins. This CAI also contains abundant sodalite and nepheline (alkali-halide) alteration that occurs around the rims of the CAI, but also penetrates more deeply into the CAI. The two types of alteration (Ca-Fe and alkali-halide) are adjacent, and very fine-grained Fe-rich phases are associated with sodalite-rich regions. Both types of alteration appear to be replacive; if that is true, it would require substantial introduction of Fe, and transport of elements (Ti, Al and Mg) out of the nodule, and introduction of Na and Cl into alkali-halide rich zones. Parts of the CAI have been extensively metasomatized.
JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity.
Kapfhamer, David; King, Ian; Zou, Mimi E; Lim, Jana P; Heberlein, Ulrike; Wolf, Fred W
2012-01-01
Neuronal signal transduction by the JNK MAP kinase pathway is altered by a broad array of stimuli including exposure to the widely abused drug ethanol, but the behavioral relevance and the regulation of JNK signaling is unclear. Here we demonstrate that JNK signaling functions downstream of the Sterile20 kinase family gene tao/Taok3 to regulate the behavioral effects of acute ethanol exposure in both the fruit fly Drosophila and mice. In flies tao is required in neurons to promote sensitivity to the locomotor stimulant effects of acute ethanol exposure and to establish specific brain structures. Reduced expression of key JNK pathway genes substantially rescued the structural and behavioral phenotypes of tao mutants. Decreasing and increasing JNK pathway activity resulted in increased and decreased sensitivity to the locomotor stimulant properties of acute ethanol exposure, respectively. Further, JNK expression in a limited pattern of neurons that included brain regions implicated in ethanol responses was sufficient to restore normal behavior. Mice heterozygous for a disrupted allele of the homologous Taok3 gene (Taok3Gt) were resistant to the acute sedative effects of ethanol. JNK activity was constitutively increased in brains of Taok3Gt/+ mice, and acute induction of phospho-JNK in brain tissue by ethanol was occluded in Taok3Gt/+ mice. Finally, acute administration of a JNK inhibitor conferred resistance to the sedative effects of ethanol in wild-type but not Taok3Gt/+ mice. Taken together, these data support a role of a TAO/TAOK3-JNK neuronal signaling pathway in regulating sensitivity to acute ethanol exposure in flies and in mice.
The Relevance of AI Research to CAI.
ERIC Educational Resources Information Center
Kearsley, Greg P.
This article provides a tutorial introduction to Artificial Intelligence (AI) research for those involved in Computer Assisted Instruction (CAI). The general theme is that much of the current work in AI, particularly in the areas of natural language understanding systems, rule induction, programming languages, and socratic systems, has important…
High precision Al-Mg systematics of forsterite-bearing Type B CAIs from CV3 chondrites
NASA Astrophysics Data System (ADS)
MacPherson, G. J.; Bullock, E. S.; Tenner, T. J.; Nakashima, D.; Kita, N. T.; Ivanova, M. A.; Krot, A. N.; Petaev, M. I.; Jacobsen, S. B.
2017-03-01
In order to further elucidate possible temporal relationships between different varieties of calcium-, aluminum-rich inclusions (CAIs), we measured the aluminum-magnesium isotopic systematics of seven examples of the rare type known as forsterite-bearing Type B (FoB) inclusions from four different CV3 carbonaceous chondrites: Allende, Efremovka, NWA 3118, and Vigarano. The primary phases (forsterite, Al-Ti-rich diopside, spinel, melilite, and anorthite) in each inclusion were analyzed in situ using high-precision secondary ion mass-spectrometry (SIMS). In all cases, minerals with low Al/Mg ratios (all except anorthite) yield well-defined internal Al-Mg isochrons, with a range of initial 26Al/27Al ratios [(26Al/27Al)0] ranging from (5.30 ± 0.22) × 10-5 down to (4.17 ± 0.43) × 10-5. Anorthite in all cases is significantly disturbed relative to the isochrons defined by the other phases in the same CAIs, and in several cases contains no resolved excesses of radiogenic 26Mg (δ26Mg∗) even at 27Al/24Mg ratios greater than 1000. The fact that some FoBs preserve (26Al/27Al)0 of ∼5.2 × 10-5, close to the canonical value of (5.23 ± 0.13) × 10-5 inferred from bulk magnesium-isotope measurements of CV CAIs (B. Jacobsen et al., 2008), demonstrates that FoBs began forming very early, contemporaneous with other more-refractory CAIs. The range of (26Al/27Al)0 values further shows that FoBs continued to be reprocessed over ∼200,000 years of nebular history, consistent with results obtained for other types of igneous CAIs in CV chondrites. The absence of any correlation between of CAI + FoB formation or reprocessing times with bulk composition or CAI type means that there is no temporal evolutionary sequence between the diverse CAI types. The initial δ26Mg∗ value in the most primitive FoB (SJ101) is significantly lower than the canonical solar system value of -0.040 ± 0.029‰.
Who Should Develop Instructional Materials for CAI?
ERIC Educational Resources Information Center
Seidel, Robert J.
The nonprofit special organization as a developer of computer-administered instruction (CAI) is advocated in this paper. The organization of universities and their mode of operation do not lend themselves to instructional product development. Faculty members engage in such efforts on a part-time basis and in competition with higher priority…
Northwest Africa 10758: A New CV3 Chondrite Bearing a Giant CAI with Hibonite-Rich Wark-Lovering Rim
NASA Technical Reports Server (NTRS)
Ross, D. K.; Simon, J. I.; Zolensky, M.
2017-01-01
Northwest Africa (NWA) 10758 is a newly identified carbonaceous chondrite that is a Bali-like oxidized CV3. The large Ca-Al rich inclusion (CAI) in this sample is approx. 2.4 x 1.4 cm. The CAI is transitional in composition between type A and type B, with interior mineralogy dominated by melilite, plus less abundant spinel and Al-Ti rich diopside, and only very minor anorthite (Fig. 1A). This CAI is largely free of secondary alteration in the exposed section we examined, with almost no nepheline, sodalite or Ca-Fe silicates. The Wark-Lovering (WL) rim on this CAI is dominated by hibonite, with lower abundances of spinel and perovskite, and with hibonite locally overlain by melilite plus perovskite (as in Fig. 1B). Note that the example shown in 1B is exceptional. Around most of the CAI, hibonite + spinel + perovskite form the WL rim, without overlying melilite. The WL rim can be unusually thick, ranging from approx.20 microns up to approx. 150 microns. A well-developed, stratified accretionary rim infills embayments of the CAI, and thins over protuberances in the convoluted CAI surface.
THE TAOS PROJECT: RESULTS FROM SEVEN YEARS OF SURVEY DATA
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zhang, Z.-W.; Lehner, M. J.; Wang, J.-H.
2013-07-01
The Taiwanese-American Occultation Survey (TAOS) aims to detect serendipitous occultations of stars by small ({approx}1 km diameter) objects in the Kuiper Belt and beyond. Such events are very rare (<10{sup -3} events per star per year) and short in duration ({approx}200 ms), so many stars must be monitored at a high readout cadence. TAOS monitors typically {approx}500 stars simultaneously at a 5 Hz readout cadence with four telescopes located at Lulin Observatory in central Taiwan. In this paper, we report the results of the search for small Kuiper Belt objects (KBOs) in seven years of data. No occultation events weremore » found, resulting in a 95% c.l. upper limit on the slope of the faint end of the KBO size distribution of q = 3.34-3.82, depending on the surface density at the break in the size distribution at a diameter of about 90 km.« less
An ion microprobe study of CAIs from CO3 meteorites. [Abstract only
NASA Technical Reports Server (NTRS)
Russell, S. S.; Greenwood, R. C.; Fahey, A. J.; Huss, G. R.; Wasserburg, G. J.
1994-01-01
When attempting to interpret the history of Ca, Al-rich inclusions (CAIs) it is often difficult to distinguish between primary features inherited from the nebula and those produced during secondary processing on the parent body. We have undertaken a systematic study of CAIs from 10 CO chondrites, believed to represent a metamorphic sequence with the goal of distinguishing primary and secondary features. ALHA 77307 (3.0), Colony (3.0), Kainsaz (3.1), Felix (3.2), ALH 82101 (3.3), Ornans (3.3), Lance (3.4), ALHA 77003 (3.5), Warrenton (3.6), and Isna (3.7) were examined by Scanning Electron Microscopy (SEM) and optical microscopy. We have identified 141 CAIs within these samples, and studied in detail the petrology of 34 inclusions. The primary phases in the lower petrologic types are spinel, melilite, and hibonite. Perovskite, FeS, ilmenite, anorthite, kirschsteinite, and metallic Fe are present as minor phases. Melilite becomes less abundant in higher petrologic types and was not detected in chondrites of type 3.5 and above, confirming previous reports that this mineral easily breaks down during heating. Iron, an element that would not be expected to condense at high temperatures, has a lower abundance in spinel from low-petrologic-type meteorites than those of higher grade, and CaTiO3 is replaced by FeTiO3 in meteorites of higher petrologic type. The abundance of CAIs is similar in each meteorite. Eight inclusions have been analyzed by ion probe. The results are summarized. The results obtained to date show that CAIs in CO meteorites, like those from other meteorite classes, contain Mg* and that Mg in some inclusions has been redistributed.
Tactical Action Officer Intelligent Tutoring System (TAO ITS)
2006-01-01
scenario. As well as the intrinsic feedback that free - play simulations naturally provide a student, the TAO ITS provides detailed, useful extrinsic feedback...incorporate use of free - play simulators into their curriculum, affordably. This is a major shortcoming of conventional CBT as student manipulation of...tutoring systems are ideal for incorporating desktop free - play simulators into computer-based training since the software can stand in for a human
Brunner, Franziska; Fliegner, Maike; Krupp, Kerstin; Rall, Katharina; Brucker, Sara; Richter-Appelt, Hertha
2016-01-01
The perception of gender development of individuals with complete androgen insensitivity syndrome (CAIS) as unambiguously female has recently been challenged in both qualitative data and case reports of male gender identity. The aim of the mixed-method study presented was to examine the self-perception of CAIS individuals regarding different aspects of gender and to identify commonalities and differences in comparison with subfertile and infertile XX-chromosomal women with diagnoses of Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) and polycystic ovary syndrome (PCOS). The study sample comprised 11 participants with CAIS, 49 with MRKHS, and 55 with PCOS. Gender identity was assessed by means of a multidimensional instrument, which showed significant differences between the CAIS group and the XX-chromosomal women. Other-than-female gender roles and neither-female-nor-male sexes/genders were reported only by individuals with CAIS. The percentage with a not exclusively androphile sexual orientation was unexceptionally high in the CAIS group compared to the prevalence in "normative" women and the clinical groups. The findings support the assumption made by Meyer-Bahlburg ( 2010 ) that gender outcome in people with CAIS is more variable than generally stated. Parents and professionals should thus be open to courses of gender development other than typically female in individuals with CAIS.
Na/Ca exchange in the basolateral membrane of the A6 cell monolayer: role in Cai homeostasis.
Brochiero, E; Raschi, C; Ehrenfeld, J
1995-05-01
The presence of a Na/Ca exchanger in A6 cells was investigated by measuring intracellular calcium (Cai) fluctuations and the 45Ca fluxes through the basolateral membranes (blm) of the cell monolayer. Removal of Na+ from the medium produced a transient increase in Cai followed by a regulatory phase returning Cai to control levels in 3-4 min, this phase being greatly accelerated (< 60 s) by NaCl addition (apparent Km of approximately 5 mM Na+). The Cai increase was only found with the Na(+)-free medium on the basolateral side of the cell monolayer. A twofold increase in the 45Ca influx was observed under these conditions. In Ca(2+)- depleted cells, the initial Cai increase after Ca2+ addition to the medium was greater when the putative Na/Ca exchanger was not functioning (i.e. in a Na(+)-free medium). 45Ca effluxes through the blm of the monolayer were greatly and transiently increased by a Na(+)-free medium on the serosal side and blocked by orthovanadate (1 mM). The Cai increased induced by a hypo-osmotic shock was greater in cells bathed in a Na(+)-medium, conditions expected to block the activity of the Na/Ca exchanger. These findings support the hypothesis that a Na/Ca exchanger is present on the blm of A6 cells and affirm its role in Cai homeostasis in steady-state conditions and following osmotic shock. In addition, a Ca2+ pump also located on the blm and Ca2+ stores sensitive to inositol 1,4,5-trisphosphate were found to be implicated in Cai homeostasis.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Twitty, A.F.; Handler, B.H.; Duncan, L.D.
Data Systems Engineering Organization (DSEO) personnel are developing a prototype computer aided instruction (CAI) system for the Naval Aviation Logistics Data Analysis (NALDA) system. The objective of this project is to provide a prototype for implementing CAI as an enhancement to existing NALDA training. The CAI prototype project is being performed in phases. The task undertaken in Phase I was to analyze the problem and the alternative solutions and to develop a set of recommendations on how best to proceed. In Phase II a structured design and specification document was completed that will provide the basis for development and implementationmore » of the desired CAI system. Phase III will consist of designing, developing, and testing a user interface which will extend the features of the Phase II prototype. The design of the CAI prototype has followed a rigorous structured analysis based on Yourdon/DeMarco methodology and Information Engineering tools. This document includes data flow diagrams, a data dictionary, process specifications, an entity-relationship diagram, a curriculum description, special function key definitions, and a set of standards developed for the NALDA CAI Prototype.« less
NASA Astrophysics Data System (ADS)
Oishi, Y.; Ishida, H.; Nakajima, T. Y.
2016-12-01
Greenhouse gases Observing SATellite-2 (GOSAT-2) will be launched in fiscal 2017 to determine atmospheric concentrations of greenhouse gases, such as CO2, CH4, and CO. GOSAT-2 will be equipped with two sensors: the Thermal and Near-infrared Sensor for Carbon Observation (TANSO)-Fourier Transform Spectrometer-2 (FTS-2) and TANSO-Cloud and Aerosol Imager-2 (CAI-2). CAI-2 is a push-broom imaging sensor that has forward- and backward-looking bands for observing the optical properties of aerosols and clouds, and for monitoring the status of urban air pollution and transboundary air pollution over oceans. An important role of CAI-2 is to perform cloud discrimination in each direction. The Cloud and Aerosol Unbiased Decision Intellectual Algorithm (CLAUDIA1), which applies sequential threshold tests to features, has been used in GOSAT CAI L2 cloud flag processing. If CLAUDIA1 used with CAI-2, it is necessary to optimize the thresholds in accordance with CAI-2. Meanwhile, CLAUDIA3 using support vector machines (SVM), which is a supervised pattern recognition method, was developed for GOSAT-2 CAI-2 L2 cloud discrimination processing. Thus, CLAUDIA3 can automatically find the optimized boundary between clear and cloudy. Improvement of the CLAUDIA3 used with CAI (CLAUDIA3-CAI) has carried out and is still continuing. In this study we compared results of CLAUDIA3-CAI using Terra MODIS data and GOSAT CAI data as training data to clarify the impact of the use of different satellite data as training data against GOSAT-2 CAI-2 L2 cloud discrimination. We will present our latest results.
Wong, Wai-Man R; Stephens, Jeffrey W; Acharya, Jayshree; Hurel, Steven J; Humphries, Steve E; Talmud, Philippa J
2004-08-01
Apolipoprotein A-IV (apoA-IV) has been postulated to be antiatherogenic. Transgenic APOA4/Apoe-/- mice are protected against atherosclerosis, with plasma apoA-IV displaying antioxidant activity in vitro. In humans, there is an inverse relationship between apoA-IV levels and risk of coronary heart disease (CHD). Furthermore, the APOA4 T347S rare allele has been associated with increased risk of CHD and reduced apoA-IV levels. Reduced total antioxidant status (TAOS) due to increased oxidative stress is implicated in the process of atherogenesis. Thus, this study aimed to examine the association between the APOA4 T347S variant and TAOS in diabetic patients with (n = 196) or without (n = 509) cardiovascular disease (CVD). A higher percentage of CVD patients were present in the lowest quartile of TAOS, compared with the rest (P = 0.04). Overall, there was no association between genotype and TAOS. However, in patients with CVD, homozygotes for the S347 allele had significantly lower TAOS compared with TT and TS subjects (31.2 +/- 9.89% and 42.5 +/- 13.04% TAOS, respectively; P = 0.0024), an effect that was not seen in the patients without CVD. This study offers direct support for an antioxidant capacity of apoA-IV, thus providing some explanation for the antiatherogenic role of apoA-IV and the higher CVD risk in S347 homozygotes. Copyright 2004 American Society for Biochemistry and Molecular Biology, Inc.
A Multi-Media CAI Terminal Based upon a Microprocessor with Applications for the Handicapped.
ERIC Educational Resources Information Center
Brebner, Ann; Hallworth, H. J.
The design of the CAI interface described is based on the microprocessor in order to meet three basic requirements for providing appropriate instruction to the developmentally handicapped: (1) portability, so that CAI can be taken into the customary learning environment; (2) reliability; and (3) flexibility, to permit use of new input and output…
Taos Smart Growth Implementation Assistance: Concepts for the Paseo del Pueblo Sur Corridor
This report describes a technical assistance project with Taos, NM, to help make development along State Highway 68, the Paseo del Pueblo Sur commercial corridor, economically stronger and more attractive.
A FIB/TEM Study of a Complex Wark-Lovering Rim on a Vigarano CAI
NASA Technical Reports Server (NTRS)
Keller, L. P.; Needham, A. W.; Messenger, S.
2013-01-01
Wark-Lovering (WL) rims are thin multilayered mineral sequences that surround most Ca, Al-rich inclusions (CAIs). Several processes have been proposed for WL rim formation, including condensation, flash-heating or reaction with a nebular reservoir, or combinations of these [e.g. 1-7], but no consensus exists. Our previous coordinated transmission electron microscope (TEM) and NanoSIMS O isotopic measurements showed that a WL rim experienced flash heating events in a nebular environment with planetary O isotopic composition, distinct from the (16)O-rich formation environment [6]. Our efforts have focused on CAIs from the CV(sub red) chondrites, especially Vigarano, because these have escaped much of the parent body alteration effects that are common in CAIs from CV(sub ox) group.
ERIC Educational Resources Information Center
Lintz, Larry M.; And Others
This study investigated the feasibility of a low cost computer-aided instruction/computer-managed instruction (CAI/CMI) system. Air Force instructors and training supervisors were surveyed to determine the potential payoffs of various CAI and CMI functions. Results indicated that a wide range of capabilities had potential for resident technical…
NASA Astrophysics Data System (ADS)
Rubin, Alan E.
2012-06-01
In the scenario developed here, most types of calcium-aluminum-rich inclusions (CAIs) formed near the Sun where they developed Wark-Lovering rims before being transported by aerodynamic forces throughout the nebula. The amount of ambient dust in the nebula varied with heliocentric distance, peaking in the CV-CK formation location. Literature data show that accretionary rims (which occur outside the Wark-Lovering rims) around CAIs contain substantial 16O-rich forsterite, suggesting that, at this time, the ambient dust in the nebula consisted largely of 16O-rich forsterite. Individual sub-millimeter-size Compact Type-A CAIs (each surrounded by a Wark-Lovering rim) collided in the CV-CK region and stuck together (in a manner similar to that of sibling compound chondrules); the CTAs were mixed with small amounts of 16O-rich mafic dust and formed centimeter-size compound objects (large Fluffy Type-A CAIs) after experiencing minor melting. In contrast to other types of CAIs, centimeter-size Type-B CAIs formed directly in the CV-CK region after gehlenite-rich Compact Type-A CAIs collided and stuck together, incorporated significant amounts of 16O-rich forsteritic dust (on the order of 10-15%) and probably some anorthite, and experienced extensive melting and partial evaporation. (Enveloping compound chondrules formed in an analogous manner.) In those cases where appreciably higher amounts of 16O-rich forsterite (on the order of 25%) (and perhaps minor anorthite and pyroxene) were incorporated into compound Type-A objects prior to melting, centimeter-size forsterite-bearing Type-B CAIs (B3 inclusions) were produced. Type-B1 inclusions formed from B2 inclusions that collided with and stuck to melilite-rich Compact Type-A CAIs and experienced high-temperature processing.
The Cost of CAI: A Matter of Assumptions.
ERIC Educational Resources Information Center
Kearsley, Greg P.
Cost estimates for Computer Assisted Instruction (CAI) depend crucially upon the particular assumptions made about the components of the system to be included in the costs, the expected lifetime of the system and courseware, and the anticipated student utilization of the system/courseware. The cost estimates of three currently operational systems…
Audiomagnetotelluric data, Taos Plateau Volcanic Field, New Mexico
Ailes, Chad E.; Rodriguez, Brian D.
2011-01-01
The U.S. Geological Survey is conducting a series of multidisciplinary studies of the San Luis Basin as part of the Geologic framework of the Rio Grande Basins project. Detailed geologic mapping, high-resolution airborne magnetic surveys, gravity surveys, audiomagnetotelluric surveys, and hydrologic and lithologic data are being used to better understand the aquifers. This report describes a regional east-west audiomagnetotelluric sounding profile acquired in late July 2009 across the Taos Plateau Volcanic Field. No interpretation of the data is included.
Water resources of Taos County, New Mexico
Garrabrant, Lynn A.
1993-01-01
In Taos County, ground water generally is unconfined and moves toward the Rio Grande or perennial streams. Water quality is good except in some areas where water has high values of specific conductance and hardness and contains high concentrations of dissolved solids and fluoride. Most wells are completed in alluvial sediments of Quaternary and Tertiary age in the Costilla Plains. A few wells are completed in basalt of the Taos Plateau and in alluvium of stream channels in the Sangre de Cristo Mountains. Depths to water in wells range from less than 1 to 1,080 feet below land surface. Well yields range from 1 to 3,000 gallons per minute. Water levels in wells in Sunshine Valley dropped 5 to 50 feet between 1955 and 1970. Ground-water irrigation has since declined and water levels have risen. Surface-water records show the county is a net producer of water. The average discharge gained in the Rio Grande as it flows through the county was 271,700 acre-feet per year for water years 1931-89. The highest mean monthly discharge occurs in May or June due to snowmelt runoff. Water quality ranges from good in upstream reaches to fair in lower reaches. Surface water was the source for 93 percent of water withdrawn in 1990, but ground water was used for all public supply, domestic, and industrial purposes. The largest water use is irrigation. About 28,500 acres were irrigated in 1990; alfalfa, native pasture, and planted pasture accounted for 91 percent of this acreage.
Buchet, Anne; Eichler, Knut; Mandrand-Berthelot, Marie-Andrée
1998-01-01
The divergent structural operons caiTABCDE and fixABCX of Escherichia coli are required for anaerobic carnitine metabolism. Transcriptional monocopy lacZ fusion studies showed that both operons are coexpressed during anaerobic growth in the presence of carnitine, respond to common environmental stimuli (like glucose and nitrate), and are modulated positively by the same general regulators, CRP and FNR, and negatively by H-NS. Overproduction of the CaiF specific regulatory protein mediating the carnitine signal restored induction in an fnr mutant, corresponding to its role as the primary target for anaerobiosis. Transcript analysis identified two divergent transcription start points initiating 289 bp apart. DNase I footprinting revealed three sites with various affinities for the binding of the cAMP-CRP complex inside this regulatory region. Site-directed mutagenesis experiments indicated that previously reported perfect CRP motif 1, centered at −41.5 of the cai transcriptional start site, plays a direct role in the sole cai activation. In contrast, mutation in CRP site 2, positioned at −69.5 of the fix promoter, caused only a threefold reduction in fix expression. Thus, the role of the third CRP site, located at −126.5 of fix, might be to reinforce the action of site 2. A critical 50-bp cis-acting sequence overlapping the fix mRNA start site was found, by deletion analysis, to be necessary for cai transcription. This region is thought to be involved in transduction of the signal mediated by the CaiF regulator. PMID:9573142
Pt nanoparticle on La0.02Na0.98TaO3 catalyst for hydrogen evolution from glycerol aqueous solution
NASA Astrophysics Data System (ADS)
Husin, Husni; Adisalamun, Sy, Yuliana; Asnawi, Teku Muhammad; Hasfita, Fikri
2017-01-01
Pt nanoparticles on La-doped sodium tantalum oxide (La0.02Na0.98TaO3), which acts as an active co-catalyst for H2 evolution under UV light irradiation was successfully synthesized by photo-deposition method. The La0.02Na0.98TaO3 photocatalyst was obtained by the reaction of La(NO3)2.3H2O, TaCl5, and NaOH at ambient temperature. The catalyst produced was characterized by a scanning electron microscope (SEM) and a high-resolution transmission electron microscope (HRTEM). SEM images of the La0.02Na0.98TaO3 sample showing that its particles size is ranging between 50-150 nm. The Pt particles are detected from HRTEM images is around 2-4 nm. The Pt/La0.02Na0.98TaO3 samples prepared were applied for photocatalytic H2 production at 30°C. The photocatalyst performance was evaluated for hydrogen production from water combining with glycerol as an electron donor (sacrificial reagent). The reactions were carried out in a closed reactor with a gas circulation system, illuminated with mercury (Hg) lamp. The experimental results show that the presence of glycerol in the systems can not only improve the efficiency of photocatalytic hydrogen generation but can also be decomposed to hydrogen efficiently. The photocatalytic activity of La0.02Na0.98TaO3 is significantly enhanced when Pt was loaded onto its crystalline surface.
Ventura, Joseph; Reise, Steven P; Keefe, Richard S E; Baade, Lyle E; Gold, James M; Green, Michael F; Kern, Robert S; Mesholam-Gately, Raquelle; Nuechterlein, Keith H; Seidman, Larry J; Bilder, Robert M
2010-08-01
Practical, reliable "real world" measures of cognition are needed to supplement neurocognitive performance data to evaluate possible efficacy of new drugs targeting cognitive deficits associated with schizophrenia. Because interview-based measures of cognition offer one possible approach, data from the MATRICS initiative (n=176) were used to examine the psychometric properties of the Schizophrenia Cognition Rating Scale (SCoRS) and the Clinical Global Impression of Cognition in Schizophrenia (CGI-CogS). We used classical test theory methods and item response theory to derive the 10-item Cognitive Assessment Interview (CAI) from the SCoRS and CGI-CogS ("parent instruments"). Sources of information for CAI ratings included the patient and an informant. Validity analyses examined the relationship between the CAI and objective measures of cognitive functioning, intermediate measures of cognition, and functional outcome. The rater's score from the newly derived CAI (10 items) correlate highly (r=.87) with those from the combined set of the SCoRS and CGI-CogS (41 items). Both the patient (r=.82) and the informant (r=.95) data were highly correlated with the rater's score. The CAI was modestly correlated with objectively measured neurocognition (r=-.32), functional capacity (r=-.44), and functional outcome (r=-.32), which was comparable to the parent instruments. The CAI allows for expert judgment in evaluating a patient's cognitive functioning and was modestly correlated with neurocognitive functioning, functional capacity, and functional outcome. The CAI is a brief, repeatable, and potentially valuable tool for rating cognition in schizophrenia patients who are participating in clinical trials. Copyright 2010 Elsevier B.V. All rights reserved.
NASA Astrophysics Data System (ADS)
Williams, C. D.; Ushikubo, T.; Bullock, E. S.; Janney, P. E.; Hines, R. R.; Kita, N. T.; Hervig, R. L.; MacPherson, G. J.; Mendybaev, R. A.; Richter, F. M.; Wadhwa, M.
2017-03-01
Detailed petrologic, geochemical and isotopic analyses of a new FUN CAI from the Allende CV3 meteorite (designated CMS-1) indicate that it formed by extensive melting and evaporation of primitive precursor material(s). The precursor material(s) condensed in a 16O-rich region (δ17O and δ18O ∼ -49‰) of the inner solar nebula dominated by gas of solar composition at total pressures of ∼10-3-10-6 bar. Subsequent melting of the precursor material(s) was accompanied by evaporative loss of magnesium, silicon and oxygen resulting in large mass-dependent isotope fractionations in these elements (δ25Mg = 30.71-39.26‰, δ29Si = 14.98-16.65‰, and δ18O = -41.57 to -15.50‰). This evaporative loss resulted in a bulk composition similar to that of compact Type A and Type B CAIs, but very distinct from the composition of the original precursor condensate(s). Kinetic fractionation factors and the measured mass-dependent fractionation of silicon and magnesium in CMS-1 suggest that ∼80% of the silicon and ∼85% of the magnesium were lost from its precursor material(s) through evaporative processes. These results suggest that the precursor material(s) of normal and FUN CAIs condensed in similar environments, but subsequently evolved under vastly different conditions such as total gas pressure. The chemical and isotopic differences between normal and FUN CAIs could be explained by sorting of early solar system materials into distinct physical and chemical regimes, in conjunction with discrete heating events, within the protoplanetary disk.
Ventura, Joseph; Reise, Steven P.; Keefe, Richard S. E.; Baade, Lyle E.; Gold, James M.; Green, Michael F.; Kern, Robert S.; Mesholam-Gately, Raquelle; Nuechterlein, Keith H.; Seidman, Larry J.; Bilder, Robert M.
2011-01-01
Background Practical, reliable “real world” measures of cognition are needed to supplement neurocognitive performance data to evaluate possible efficacy of new drugs targeting cognitive deficits associated with schizophrenia. Because interview-based measures of cognition offer one possible approach, data from the MATRICS initiative (n=176) were used to examine the psychometric properties of the Schizophrenia Cognition Rating Scale (SCoRS) and the Clinical Global Impression of Cognition in Schizophrenia (CGI-CogS). Method We used classical test theory methods and item response theory to derive the 10 item Cognitive Assessment Interview (CAI) from the SCoRS and CGI-Cogs (“parent instruments”). Sources of information for CAI ratings included the patient and an informant. Validity analyses examined the relationship between the CAI and objective measures of cognitive functioning, intermediate measures of cognition, and functional outcome. Results The rater’s score from the newly derived CAI (10-items) correlate highly (r = .87) with those from the combined set of the SCoRS and CGI-CogS (41 items). Both the patient (r= .82) and the informant (r= .95) data were highly correlated with the rater’s score. The CAI was modestly correlated with objectively measured neurocognition (r = −.32), functional capacity (r = −.44), and functional outcome (r = −.32), which was comparable to the parent instruments. Conclusions The CAI allows for expert judgment in evaluating a patient’s cognitive functioning and was modestly correlated with neurocognitive functioning, functional capacity, and functional outcome. The CAI is a brief, repeatable, and potentially valuable tool for rating cognition in schizophrenia patients who are participating in clinical trials. PMID:20542412
NASA Astrophysics Data System (ADS)
Frank, D. R.; Huss, G. R.; Nagashima, K.; Zolensky, M. E.; Le, L.
2017-07-01
The only whole CAI preserved in the aqueously altered CI chondrites is 16O-rich and has no resolvable radiogenic Mg. Accretion of CAIs by the CI parent object(s) may limit the precision of cosmochemical models that require a CI starting composition.
NASA Astrophysics Data System (ADS)
Zhang, Yumin
2014-12-01
Microelectronics is a challenging course to many undergraduate students and is often described as very messy. Before taking this course, all the students have learned circuit analysis, where basically all the problems can be solved by applying Kirchhoff's laws. In addition, most engineering students have also learned engineering mechanics: statics and dynamics, where Newton's laws and related principles can be applied in solving all the problems. However, microelectronics is not as clean as these courses. There are hundreds of equations for different circuits, and it is impossible to remember which equation should be applied to which circuit. One of the common pitfalls in learning this course is over-focusing at the equation level and ignoring the ideas (Tao) behind it. Unfortunately, these ideas are not summarized and emphasized in most microelectronics textbooks, though they cover various electronic circuits comprehensively. Therefore, most undergraduate students feel at a loss when they start to learn this topic. This book tries to illustrate the major ideas and the basic analysis techniques, so that students can derive the right equations easily when facing an electronic circuit.
An Intelligent CAI Monitor and Generative Tutor. Interim Report.
ERIC Educational Resources Information Center
Koffman, Elliot B.; And Others
Design techniques for generative computer-assisted-instructional (CAI) systems are described in this report. These are systems capable of generating problems for students and of deriving and monitoring solutions; problem difficulty, instructional pace, and depth of monitoring are all individually tailored and parts of the solution algorithms can…
The CAI/Cooperative Learning Project. First Year Evaluation Report.
ERIC Educational Resources Information Center
Beyer, Francine S.
This report presents a first year evaluation of the Computer Assisted Instruction (CAI)/ Cooperative Learning Project, a 3-year collaborative effort by two Pennsylvania school districts--the Pittston Area School District and the Hatboro-Horsham School District--and Research for Better Schools (RBS). The project proposed to integrate advanced…
ERIC Educational Resources Information Center
Kaousar, Tayyeba; Choudhry, Bushra Naoreen; Gujjar, Aijaz Ahmed
2008-01-01
This study was aimed to evaluate the effectiveness of CAI vs. classroom lecture for computer science at ICS level. The objectives were to compare the learning effects of two groups with classroom lecture and computer-assisted instruction studying the same curriculum and the effects of CAI and CRL in terms of cognitive development. Hypotheses of…
DOE Office of Scientific and Technical Information (OSTI.GOV)
Gounelle, Matthieu; Chaussidon, Marc; Rollion-Bard, Claire, E-mail: gounelle@mnhn.fr
2013-02-01
A search for short-lived {sup 10}Be in 21 calcium-aluminum-rich inclusions (CAIs) from Isheyevo, a rare CB/CH chondrite, showed that only 5 CAIs had {sup 10}B/{sup 11}B ratios higher than chondritic correlating with the elemental ratio {sup 9}Be/{sup 11}B, suggestive of in situ decay of this key short-lived radionuclide. The initial ({sup 10}Be/{sup 9}Be){sub 0} ratios vary between {approx}10{sup -3} and {approx}10{sup -2} for CAI 411. The initial ratio of CAI 411 is one order of magnitude higher than the highest ratio found in CV3 CAIs, suggesting that the more likely origin of CAI 411 {sup 10}Be is early solar systemmore » irradiation. The low ({sup 26}Al/{sup 27}Al){sub 0} [{<=} 8.9 Multiplication-Sign 10{sup -7}] with which CAI 411 formed indicates that it was exposed to gradual flares with a proton fluence of a few 10{sup 19} protons cm{sup -2}, during the earliest phases of the solar system, possibly the infrared class 0. The irradiation conditions for other CAIs are less well constrained, with calculated fluences ranging between a few 10{sup 19} and 10{sup 20} protons cm{sup -2}. The variable and extreme value of the initial {sup 10}Be/{sup 9}Be ratios in carbonaceous chondrite CAIs is the reflection of the variable and extreme magnetic activity in young stars observed in the X-ray domain.« less
Rare Earth Element Measurements of Melilite and Fassaite in Allende Cai by Nanosims
NASA Technical Reports Server (NTRS)
Ito, M.; Messenger, Scott
2009-01-01
The rare earth elements (REEs) are concentrated in CAIs by approx. 20 times the chondritic average [e.g., 1]. The REEs in CAIs are important to understand processes of CAI formation including the role of volatilization, condensation, and fractional crystallization [1,2]. REE measurements are a well established application of ion microprobes [e.g., 3]. However the spatial resolution of REE measurements by ion microprobe (approx.20 m) is not adequate to resolve heterogeneous distributions of REEs among/within minerals. We have developed methods for measuring REE with the NanoSIMS 50L at smaller spatial scales. Here we present our initial measurements of REEs in melilite and fassaite in an Allende Type-A CAI with the JSC NanoSIMS 50L. We found that the key parameters for accurate REE abundance measurements differ between the NanoSIMS and conventional SIMS, in particular the oxide-to-element ratios, the relative sensitivity factors, the energy distributions, and requisite energy offset. Our REE abundance measurements of the 100 ppm REE diopside glass standards yielded good reproducibility and accuracy, 0.5-2.5 % and 5-25 %, respectively. We determined abundances and spatial distributions of REEs in core and rim within single crystals of fassaite, and adjacent melilite with 5-10 m spatial resolution. The REE abundances in fassaite core and rim are 20-100 times CI abundance but show a large negative Eu anomaly, exhibiting a well-defined Group III pattern. This is consistent with previous work [4]. On the other hand, adjacent melilite shows modified Group II pattern with no strong depletions of Eu and Yb, and no Tm positive anomaly. REE abundances (2-10 x CI) were lower than that of fassaite. These patterns suggest that fassaite crystallized first followed by a crystallization of melilite from the residual melt. In future work, we will carry out a correlated study of O and Mg isotopes and REEs of the CAI in order to better understand the nature and timescales of its
Stable Magnesium Isotope Variation in Melilite Mantle of Allende Type B1 CAI EK 459-5-1
NASA Technical Reports Server (NTRS)
Kerekgyarto, A. G.; Jeffcoat, C. R.; Lapen, T. J.; Andreasen, R.; Righter, M.; Ross, D. K.
2014-01-01
Ca-Al-rich inclusions (CAIs) are the earliest formed crystalline material in our solar system and they record early Solar System processes. Here we present petrographic and delta Mg-25 data of melilite mantles in a Type B1 CAI that records early solar nebular processes.
Oxygen reservoirs in the early solar nebula inferred from an Allende CAI.
Young, E D; Russell, S S
1998-10-16
Ultraviolet laser microprobe analyses of a calcium-aluminum-rich inclusion (CAI) from the Allende meteorite suggest that a line with a slope of exactly 1.00 on a plot of delta (17)O against delta (18)O represents the primitive oxygen isotope reservoir of the early solar nebula. Most meteorites are enriched in (17)O and (18)O relative to this line, and their oxygen isotope ratios can be explained by mass fractionation or isotope exchange initiating from the primitive reservoir. These data establish a link between the oxygen isotopic composition of the abundant ordinary chondrites and the primitive (16)O-rich component of CAIs.
Oxygen reservoirs in the early solar nebula inferred from an allende CAI
Young; Russell
1998-10-16
Ultraviolet laser microprobe analyses of a calcium-aluminum-rich inclusion (CAI) from the Allende meteorite suggest that a line with a slope of exactly 1.00 on a plot of delta17O against delta18O represents the primitive oxygen isotope reservoir of the early solar nebula. Most meteorites are enriched in 17O and 18O relative to this line, and their oxygen isotope ratios can be explained by mass fractionation or isotope exchange initiating from the primitive reservoir. These data establish a link between the oxygen isotopic composition of the abundant ordinary chondrites and the primitive 16O-rich component of CAIs.
Alternative communication network designs for an operational Plato 4 CAI system
NASA Technical Reports Server (NTRS)
Mobley, R. E., Jr.; Eastwood, L. F., Jr.
1975-01-01
The cost of alternative communications networks for the dissemination of PLATO IV computer-aided instruction (CAI) was studied. Four communication techniques are compared: leased telephone lines, satellite communication, UHF TV, and low-power microwave radio. For each network design, costs per student contact hour are computed. These costs are derived as functions of student population density, a parameter which can be calculated from census data for one potential market for CAI, the public primary and secondary schools. Calculating costs in this way allows one to determine which of the four communications alternatives can serve this market least expensively for any given area in the U.S. The analysis indicates that radio distribution techniques are cost optimum over a wide range of conditions.
NASA Astrophysics Data System (ADS)
Crosta, Giovanni Franco; Pan, Yong-Le; Aptowicz, Kevin B.; Casati, Caterina; Pinnick, Ronald G.; Chang, Richard K.; Videen, Gorden W.
2013-12-01
Measurement of two-dimensional angle-resolved optical scattering (TAOS) patterns is an attractive technique for detecting and characterizing micron-sized airborne particles. In general, the interpretation of these patterns and the retrieval of the particle refractive index, shape or size alone, are difficult problems. By reformulating the problem in statistical learning terms, a solution is proposed herewith: rather than identifying airborne particles from their scattering patterns, TAOS patterns themselves are classified through a learning machine, where feature extraction interacts with multivariate statistical analysis. Feature extraction relies on spectrum enhancement, which includes the discrete cosine FOURIER transform and non-linear operations. Multivariate statistical analysis includes computation of the principal components and supervised training, based on the maximization of a suitable figure of merit. All algorithms have been combined together to analyze TAOS patterns, organize feature vectors, design classification experiments, carry out supervised training, assign unknown patterns to classes, and fuse information from different training and recognition experiments. The algorithms have been tested on a data set with more than 3000 TAOS patterns. The parameters that control the algorithms at different stages have been allowed to vary within suitable bounds and are optimized to some extent. Classification has been targeted at discriminating aerosolized Bacillus subtilis particles, a simulant of anthrax, from atmospheric aerosol particles and interfering particles, like diesel soot. By assuming that all training and recognition patterns come from the respective reference materials only, the most satisfactory classification result corresponds to 20% false negatives from B. subtilis particles and <11% false positives from all other aerosol particles. The most effective operations have consisted of thresholding TAOS patterns in order to reject defective ones
NASA Astrophysics Data System (ADS)
Jacobsen, Benjamin; Yin, Qing-zhu; Moynier, Frederic; Amelin, Yuri; Krot, Alexander N.; Nagashima, Kazuhide; Hutcheon, Ian D.; Palme, Herbert
2008-07-01
The precise knowledge of the initial 26Al/ 27Al ratio [( 26Al/ 27Al) 0] is crucial if we are to use the very first solid objects formed in our Solar System, calcium-aluminum-rich inclusions (CAIs) as the "time zero" age-anchor and guide future work with other short-lived radio-chronometers in the early Solar System, as well as determining the inventory of heat budgets from radioactivities for early planetary differentiation. New high-precision multi-collector inductively-coupled plasma mass spectrometry (MC-ICP-MS) measurements of 27Al/ 24Mg ratios and Mg-isotopic compositions of nine whole-rock CAIs (six mineralogically characterized fragments and three micro-drilled inclusions) from the CV carbonaceous chondrite, Allende yield a well-defined 26Al- 26Mg fossil isochron with an ( 26Al/ 27Al) 0 of (5.23 ± 0.13) × 10 - 5 . Internal mineral isochrons obtained for three of these CAIs ( A44A, AJEF, and A43) are consistent with the whole-rock CAI isochron. The mineral isochron of AJEF with ( 26Al/ 27Al) 0 = (4.96 ± 0.25) × 10 - 5 , anchored to our precisely determined absolute 207Pb- 206Pb age of 4567.60 ± 0.36 Ma for the same mineral separates, reinstate the "canonical" ( 26Al/ 27Al) 0 of 5 × 10 - 5 for the early Solar System. The uncertainty in ( 26Al/ 27Al) 0 corresponds to a maximum time span of ± 20 Ka (thousand years), suggesting that the Allende CAI formation events were culminated within this time span. Although all Allende CAIs studied experienced multistage formation history, including melting and evaporation in the solar nebula and post-crystallization alteration likely on the asteroidal parent body, the 26Al- 26Mg and U-Pb-isotopic systematics of the mineral separates and bulk CAIs behaved largely as closed-system since their formation. Our data do not support the "supra-canonical" 26Al/ 27Al ratio of individual minerals or their mixtures in CV CAIs, suggesting that the supra-canonical 26Al/ 27Al ratio in the CV CAIs may have resulted from post
ERIC Educational Resources Information Center
Chinese Education and Society, 2006
2006-01-01
This article presents the decision of the People's Court in Wuhou District, Chengdu, Sichuan Province on the Jiang Tao v. Chengdu Branch, People's People's Bank of China case. Jiang Tao, the plaintiff, claimed that the defendant Chengdu Branch placed an announcement in the "Chengdu Business Daily" to "recruit tellers for Chengdu…
NASA Technical Reports Server (NTRS)
Simon, J. I.; Simon, S. B.; Nguyen, A. N.; Ross, D. K.; Messenger, S.
2017-01-01
We conducted NanoSIMS O-isotopic imaging of a primitive spinel-rich CAI spherule (27-2) from the MIL 090019 CO3 chondrite. Inclusions such as 27-2 are proposed to record inner nebula processes during an epoch of rapid solar nebula evolution. Mineralogical and textural analyses suggest that this CAI formed by high temperature reactions, partial melting, and condensation. This CAI exhibits radial O-isotopic heterogeneity among multiple occurrences of the same mineral, reflecting interactions with distinct nebular O-isotopic reservoirs.
In Situ Trace Element Analysis of an Allende Type B1 CAI: EK-459-5-1
NASA Technical Reports Server (NTRS)
Jeffcoat, C. R.; Kerekgyarto, A.; Lapen, T. J.; Andreasen, R.; Righter, M.; Ross, D. K.
2014-01-01
Variations in refractory major and trace element composition of calcium, aluminum-rich inclusions (CAIs) provide constraints on physical and chemical conditions and processes in the earliest stages of the Solar System. Previous work indicates that CAIs have experienced complex histories involving, in many cases, multiple episodes of condensation, evaporation, and partial melting. We have analyzed major and trace element abundances in two core to rim transects of the melilite mantle as well as interior major phases of a Type B1 CAI (EK-459-5-1) from Allende by electron probe micro-analyzer (EPMA) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to investigate the behavior of key trace elements with a primary focus on the REEs Tm and Yb.
NASA Astrophysics Data System (ADS)
Yusepa, B. G. P.; Kusumah, Y. S.; Kartasasmita, B. G.
2018-03-01
This study aims to get an in-depth understanding of the enhancement of students’ mathematical representation. This study is experimental research with pretest-posttest control group design. The subject of this study is the students’ of the eighth grade from junior high schools in Bandung: high-level and middle-level. In each school, two parallel groups were chosen as a control group and an experimental group. The experimental group was given cognitive apprenticeship instruction (CAI) treatment while the control group was given conventional learning. The results show that the enhancement of students’ mathematical representation who obtained CAI treatment was better than the conventional one, viewed which can be observed from the overall, mathematical prior knowledge (MPK), and school level. It can be concluded that CAI can be used as a good alternative learning model to enhance students’ mathematical representation.
Rachyla, Iryna; Pérez-Ara, Marian; Molés, Mar; Campos, Daniel; Mira, Adriana; Botella, Cristina; Quero, Soledad
2018-05-31
Adjustment Disorder (AjD) is a common and disabling mental health problem. The lack of research on this disorder has led to the absence of evidence-based interventions for its treatment. Moreover, because the available data indicate that a high percentage of people with mental illness are not treated, it is necessary to develop new ways to provide psychological assistance. The present study describes a Randomized Controlled Trial (RCT) aimed at assessing the effectiveness and acceptance of a linear internet-delivered cognitive-behavioral therapy (ICBT) intervention for AjD. A two-armed RCT was designed to compare an intervention group to a waiting list control group. Participants from the intervention group will receive TAO, an internet-based program for AjD composed of seven modules. TAO combines CBT and Positive Psychology strategies in order to provide patients with complete support, reducing their clinical symptoms and enhancing their capacity to overcome everyday adversity. Participants will also receive short weekly telephone support. Participants in the control group will be assessed before and after a seven-week waiting period, and then they will be offered the same intervention. Participants will be randomly assigned to one of the 2 groups. Measurements will be taken at five different moments: baseline, post-intervention, and three follow-up periods (3-, 6- and 12-month). BDI-II and BAI will be used as primary outcome measures. Secondary outcomes will be symptoms of AjD, posttraumatic growth, positive and negative affect, and quality of life. The development of ICBT programs like TAO responds to a need for evidence-based interventions that can reach most of the people who need them, reducing the burden and cost of mental disorders. More specifically, TAO targets AjD and will entail a step forward in the treatment of this prevalent but under-researched disorder. Finally, it should be noted that this is the first RCT focusing on an internet
Extending the granularity of representation and control for the MIL-STD CAIS 1.0 node model
NASA Technical Reports Server (NTRS)
Rogers, Kathy L.
1986-01-01
The Common APSE (Ada 1 Program Support Environment) Interface Set (CAIS) (DoD85) node model provides an excellent baseline for interfaces in a single-host development environment. To encompass the entire spectrum of computing, however, the CAIS model should be extended in four areas. It should provide the interface between the engineering workstation and the host system throughout the entire lifecycle of the system. It should provide a basis for communication and integration functions needed by distributed host environments. It should provide common interfaces for communications mechanisms to and among target processors. It should provide facilities for integration, validation, and verification of test beds extending to distributed systems on geographically separate processors with heterogeneous instruction set architectures (ISAS). Additions to the PROCESS NODE model to extend the CAIS into these four areas are proposed.
Integrating an Intelligent Tutoring System for TAOs with Second Life
2010-12-01
SL) and interacts with a number of computer -controlled objects that take on the roles of the TAO’s teammates. TAOs rely on the same mechanism to...projects that utilize both game and simulation technology for training. He joined Stottler Henke in the fall of 2000 and holds a Ph.D. in computer science...including implementing tutors in multiuser worlds. He has been at Stottler Henke since 2005 and has a MS in computer science from Stanford University
FIB-NanoSIMS-TEM Coordinated Study of a Wark-Lovering Rim in a Vigarano Type A CAI
NASA Technical Reports Server (NTRS)
Cai, A.; Ito, M.; Keller, L. P.; Ross, D. K.; Nakamura-Messenger, K.
2010-01-01
Wark-Lovering (WL) rims are thin multi layered mineral sequences that surround most Ca, Al-rich inclusions (CAIs). Unaltered WL rims are composed of the same primary high temperature minerals as CAIs, such as melilite, spinel, pyroxene, hibonite, perovskite, anorthite and olivine. It is still unclear whether the rim minerals represent a different generation formed by a separate event from their associated CAIs or are a byproduct of CAI formation. Several models have been proposed for the origins of WL rims including condensation, flashheating, reaction of a CAI with a Mg-Si-rich reservoir (nebular gas or solid); on the basis of mineralogy, abundances of trace elements, O and Mg isotopic studies. Detailed mineralogical characterizations of WL rims at micrometer to nanometer scales have been obtained by TEM observations, but so far no coordinated isotopic - mineralogical studies have been performed. Thus, we have applied an O isotopic imaging technique by NanoSIMS 50L to investigate heterogeneous distributions of O isotopic ratios in minerals within a cross section of a WL rim prepared using a focused ion beam (FIB) instrument. After the isotopic measurements, we determine the detailed mineralogy and microstructure of the same WL FIB section to gain insight into its petrogenesis. Here we present preliminary results from O isotopic and elemental maps by NanoSIMS and mineralogical analysis by FE-SEM of a FIB section of a WL rim in the Vigarano reduced CV3 chondrite.
NASA Astrophysics Data System (ADS)
Davis, Andrew M.; Zhang, Junjun; Greber, Nicolas D.; Hu, Jingya; Tissot, François L. H.; Dauphas, Nicolas
2018-01-01
Titanium isotopic compositions (mass-dependent fractionation and isotopic anomalies) were measured in 46 calcium-, aluminum-rich inclusions (CAIs) from the Allende CV chondrite. After internal normalization to 49Ti/47Ti, we found that ε50Ti values are somewhat variable among CAIs, and that ε46Ti is highly correlated with ε50Ti, with a best-fit slope of 0.162 ± 0.030 (95% confidence interval). The linear correlation between ε46Ti and ε50Ti extends the same correlation seen among bulk solar objects (slope 0.184 ± 0.007). This observation provides constraints on dynamic mixing of the solar disk and has implications for the nucleosynthetic origin of titanium isotopes, specifically on the possible contributions from various types of supernovae to the solar system. Titanium isotopic mass fractionation, expressed as δ‧49Ti, was measured by both sample-standard bracketing and double-spiking. Most CAIs are isotopically unfractionated, within a 95% confidence interval of normal, but a few are significantly fractionated and the range δ‧49Ti is from ∼-4 to ∼+4. Rare earth element patterns were measured in 37 of the CAIs. All CAIs with significant titanium mass fractionation effects have group II and related REE patterns, implying kinetically controlled volatility fractionation during the formation of these CAIs.
B and Mg isotopic variations in Leoville mrs-06 type B1 cai:origin of 10Be and 26Al
NASA Astrophysics Data System (ADS)
Chaussidon, M.; Robert, F.; Russel, S. S.; Gounelle, M.; Ash, R. D.
2003-04-01
The finding [1-3] in Ca-Al-rich refractory inclusions (CAI) of primitive chondrites of traces of the in situ decay of radioactive 10Be (half-life 1.5Myr) indicates that irradiation of the protosolar nebula by the young Sun in its T-Tauri phase has produced significant amounts of the Li-Be-B elements. This irradiation may have produced also some or all of the short-lived 26Al (half-life 0.7Myr) and 41Ca (half-life 0.1Myr) previously detected in CAIs. To constrain the origin of 10Be and 10Al it is important to look for coupled variations in the 10Be/9Be and 26Al/27Al ratios in CAIs and to understand the processes responsible for these variations (e.g. variations in the fluences of irradiation, secondary perturbations of the CAIs, ...) We have thus studied the Li and B isotopic compositions and the Be/Li and Be/B concentration ratios in one CAI (MRS-06) from the Leoville CV3 chondrite in which large variations of the Mg isotopic compositions showing both the in situ decay of 26Al and the secondary redistribution of Mg isotopes have been observed [4]. The results show large variations for the Li and B isotopic compositions (^7Li/^6Li ranging from 11.02±0.21 to 11.82±0.07, and 10B/11B ratios ranging from 0.2457±0.0053 to 0.2980±0.0085). The ^7Li/^6Li ratio tend to decrease towards the rim of the inclusion. The 10B/11B ratios are positively correlated with the ^9Be/11B ratios indicating the in situ decay of 10Be. However perturbations of the 10Be/B system are observed. They would correspond to an event which occurred approximately 2Myr after the formation of the CAI and the irradiation of the CAI precursors which is responsible for the 10Be observed in the core of the CAI. These perturbations seem compatible with those observed for the 26Al/Mg system but they might be due to an irradiation of the already-formed, isolated CAI which would have resulted in increased 10Be/^9Be ratios and low ^7Li/^6Li ratios in the margin of the CAI. [1] McKeegan K. D. et al. (2000
San Luis Valley - Taos Plateau Landscape-Level Cultural Heritage Values and Risk Assessment
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wescott, Konstance L.; Abplanalp, Jennifer M.; Brown, Jeff
The San Luis Valley – Taos Plateau Landscape-Level Cultural Heritage Values and Risk Assessment (hereafter referred to as cultural assessment) is a BLM pilot project designed to see whether the Rapid Ecoregional Assessment (REA) framework (already established and implemented throughout many ecoregions in the West) can be applied to the cultural environment.
NASA Technical Reports Server (NTRS)
Frank, D. R.; Huss, G. R.; Nagashima, K.; Zolensky, M. E.; Le, L.
2017-01-01
CI chondrites are thought to approximate the bulk solar system composition since they closely match the composition of the solar photosphere. Thus, chemical differences between a planetary object and the CI composition are interpreted to result from fractionations of a CI starting composition. This interpretation is often made despite the secondary mineralogy of CI chondrites, which resulted from low-T aqueous alteration on the parent asteroid(s). Prevalent alteration and the relatively large uncertainties in the photospheric abundances (approx. +/-5-10%) permit chemical fractionation of CI chondrites from the bulk solar system, if primary chondrules and/or CAIs have been altered beyond recognition. Isolated olivine and pyroxene grains that range from approx. 5 microns to several hundred microns have been reported in CI chondrites, and acid residues of Orgueil were found to contain refractory oxides with oxygen isotopic compositions matching CAIs. However, the only CAI found to be unambiguously preserved in a CI chondrite was identified in Ivuna. The Ivuna CAI's primary mineralogy, small size (approx.170 microns), and fine-grained igneous texture classify it as a compact type A. Aqueous alteration infiltrated large portions of the CAI, but other regions remain pristine. The major primary phases are melilite (Ak 14-36 ), grossmanite (up to 20.8 wt.% TiO 2 ), and spinel. Both melilite and grossmanite have igneous textures and zoning patterns. An accretionary rim consists primarily of olivine (Fa 2-17 ) and low-Ca pyroxene (Fs 2-10 ), which could be either surviving CI2 material or a third lithology.
NASA Astrophysics Data System (ADS)
Young, E. D.; Simon, J. I.; Russell, S. S.; Tonui, E.; Krot, A.
2004-12-01
Variations in intrinsic Mg isotope compositions provide a potentially rich record of the physiochemical evolution of CAIs. Moreover, Mg excesses from the short-lived 26Al chronometer can be used to constrain when these processes occurred; e.g., during the nebular phase and/or during the development of planetisimals (< 4 Myr). We obtained in situ UV (213 nm) laser ablation MC-ICPMS measurements of Al and Mg isotope ratios within core-to-rim traverses of igneous CAIs to place temporal constraints on when features of CAIs formed. Results provide tests of models for the chemical and isotopic evolution of CAIs involving volatilization and recondensation of elements in the solar nebula. We studied five CV3 CAIs, including Allende 3576-1 "b", Allende M5, Leoville 144A, Leoville MRS3, and Efremovka E44. Our sample-standard comparison approach affords a precision <0.2 \\permil per amu (2s) for intrinsic Mg isotope measurements and <0.3 \\permil (2s) for measured 26Mg excesses. Intra-object variation in \\delta25Mg exists with values ranging from as low as -2 \\permil and as high as +8 \\permil (compared to DSM3). The distinct Mg isotope patterns in the CAIs are difficult to explain by a single process or within a single nebular environment and likely require changing conditions or transfer of CAIs from one nebular environment to another. The ˜pristine Mg isotope profile of Leoville 144A is compared to results produced by implicit finite difference modeling. Model curves reflect isotopic fractionation at the moving surface of a shrinking molten sphere coupled with diffusion-limited transport within the sphere. We find that using mass-dependant diffusivities increases \\delta25Mg with evaporation, but does not produce the tight curvature in the edgeward increases in \\delta25Mg characteristic of Leoville 144A. Three CAIs that exhibit edgeward \\delta25Mg decreases are well described by diffusion in a Mg-rich chondritic environment suggestive of nebular temperatures and
Higher Education and Happiness: The Perspectives of the Bible and Tao Te Ching
ERIC Educational Resources Information Center
Lee, Jeong-Kyu
2017-01-01
The purpose of this paper is to discuss the concepts and principles of happiness shown in the Bible and Tao Te Ching for implications in higher education. To review the paper systematically, three research questions are addressed. First, what are happiness concepts and principles in the Bible? Second, what are happiness concepts and principles in…
Consumption of fa cai Nostoc soup: a potential for BMAA exposure from Nostoc cyanobacteria in China?
Roney, Britton R; Renhui, Li; Banack, Sandra Anne; Murch, Susan; Honegger, Rosmarie; Cox, Paul Alan
2009-01-01
Grown in arid regions of western China the cyanobacterium Nostoc flagelliforme--called fa cai in Mandarin and fat choy in Cantonese--is wild-harvested and used to make soup consumed during New Year's celebrations. High prices, up to $125 USD/kg, led to overharvesting in Inner Mongolia, Ningxia, Gansu, Qinghai, and Xinjiang. Degradation of arid ecosystems, desertification, and conflicts between Nostoc harvesters and Mongol herdsmen concerned the Chinese environmental authorities, leading to a government ban of Nostoc commerce. This ban stimulated increased marketing of a substitute made from starch. We analysed samples purchased throughout China as well as in Chinese markets in the United States and the United Kingdom. Some were counterfeits consisting of dyed starch noodles. A few samples from California contained Nostoc flagelliforme but were adulterated with starch noodles. Other samples, including those from the United Kingdom, consisted of pure Nostoc flagelliforme. A recent survey of markets in Cheng Du showed no real Nostoc flagelliforme to be marketed. Real and artificial fa cai differ in the presence of beta-N-methylamino-L-alanine (BMAA). Given its status as a high-priced luxury food, the government ban on collection and marketing, and the replacement of real fa cai with starch substitutes consumed only on special occasions, it is anticipated that dietary exposure to BMAA from fa cai will be reduced in the future in China.
Nanocomposite Phosphor Consisting of CaI2:Eu2+ Single Nanocrystals Embedded in Crystalline SiO2.
Daicho, Hisayoshi; Iwasaki, Takeshi; Shinomiya, Yu; Nakano, Akitoshi; Sawa, Hiroshi; Yamada, Wataru; Matsuishi, Satoru; Hosono, Hideo
2017-11-29
High luminescence efficiency is obtained in halide- and chalcogenide-based phosphors, but they are impractical because of their poor chemical durability. Here we report a halide-based nanocomposite phosphor with excellent luminescence efficiency and sufficient durability for practical use. Our approach was to disperse luminescent single nanocrystals of CaI 2 :Eu 2+ in a chemically stable, translucent crystalline SiO 2 matrix. Using this approach, we successfully prepared a nanocomposite phosphor by means of self-organization through a simple solid-state reaction. Single nanocrystals of 6H polytype (thr notation) CaI 2 :Eu 2+ with diameters of about 50 nm could be generated not only in a SiO 2 amorphous powder but also in a SiO 2 glass plate. The nanocomposite phosphor formed upon solidification of molten CaI 2 left behind in the crystalline SiO 2 that formed from the amorphous SiO 2 under the influence of a CaI 2 flux effect. The resulting nanocomposite phosphor emitted brilliant blue luminescence with an internal quantum efficiency up to 98% upon 407 nm violet excitation. We used cathodoluminescence microscopy, scanning transmission electron microscopy, and Rietveld refinement of the X-ray diffraction patterns to confirm that the blue luminescence was generated only by the CaI 2 :Eu 2+ single nanocrystals. The phosphor was chemically durable because the luminescence sites were embedded in the crystalline SiO 2 matrix. The phosphor is suitable for use in near-ultraviolet light-emitting diodes. The concept for this nanocomposite phosphor can be expected to be effective for improvements in the practicality of poorly durable materials such as halides and chalcogenides.
Hunting and use of terrestrial fauna used by Caiçaras from the Atlantic Forest coast (Brazil)
2009-01-01
Background The Brazilian Atlantic Forest is considered one of the hotspots for conservation, comprising remnants of rain forest along the eastern Brazilian coast. Its native inhabitants in the Southeastern coast include the Caiçaras (descendants from Amerindians and European colonizers), with a deep knowledge on the natural resources used for their livelihood. Methods We studied the use of the terrestrial fauna in three Caiçara communities, through open-ended interviews with 116 native residents. Data were checked through systematic observations and collection of zoological material. Results The dependence on the terrestrial fauna by Caiçaras is especially for food and medicine. The main species used are Didelphis spp., Dasyprocta azarae, Dasypus novemcinctus, and small birds (several species of Turdidae). Contrasting with a high dependency on terrestrial fauna resources by native Amazonians, the Caiçaras do not show a constant dependency on these resources. Nevertheless, the occasional hunting of native animals represents a complimentary source of animal protein. Conclusion Indigenous or local knowledge on native resources is important in order to promote local development in a sustainable way, and can help to conserve biodiversity, particularly if the resource is sporadically used and not commercially exploited. PMID:19930595
NASA Astrophysics Data System (ADS)
Füri, Evelyn; Chaussidon, Marc; Marty, Bernard
2015-03-01
Nitrogen and noble gas (Ne-Ar) abundances and isotope ratios, determined by CO2 laser extraction static mass spectrometry analysis, as well as Al-Mg and O isotope data from secondary ion mass spectrometry (SIMS) analyses, are reported for a type B calcium-aluminum-rich inclusion (CAI) from the CV3 chondrite NWA 8616. The high (26Al/27Al)i ratio of (5.06 ± 0.50) × 10-5 dates the last melting event of the CAI at 39-99+109ka after "time zero", limiting the period during which high-temperature exchanges between the CAI and the nebular gas could have occurred to a very short time interval. Partial isotopic exchange with a 16O-poor reservoir resulted in Δ17O > -5‰ for melilite and anorthite, whereas spinel and Al-Ti-pyroxene retain the inferred original 16O-rich signature of the solar nebula (Δ17O ⩽ -20‰). The low 20Ne/22Ne (⩽0.83) and 36Ar/38Ar (⩽0.75) ratios of the CAI rule out the presence of any trapped planetary or solar noble gases. Cosmogenic 21Ne and 38Ar abundances are consistent with a cosmic ray exposure (CRE) age of ∼14 to 20 Ma, assuming CR fluxes similar to modern ones, without any evidence for pre-irradiation of the CAI before incorporation into the meteorite parent body. Strikingly, the CAI contains 1.4-3.4 ppm N with a δ15N value of +8‰ to +30‰. Even after correcting the measured δ15N values for cosmogenic 15N produced in situ, the CAI is highly enriched in 15N compared to the protosolar nebula (δ15NPSN = -383 ± 8‰; Marty et al., 2011), implying that the CAI-forming region was contaminated by 15N-rich material within the first 0.15 Ma of Solar System history, or, alternatively, that the CAI was ejected into the outer Solar System where it interacted with a 15N-rich reservoir.
Al-rich Chondrules: Petrologic Basis for Their Diversity, and Relation to Type C CAIs
NASA Technical Reports Server (NTRS)
MacPherson, G. J.; Huss, G. R.
2003-01-01
Al-rich chondrules share mineralogical and chemical properties with, and are intermediate in a volatility sense between, CAIs and ferromagnesian chondrules. In some way they must be petrogenetic links between the two. A recent upsurge of interest in Al-rich chondrules is due to their constituent plagioclase feldspar and Al-rich glass being amenable to successful ion microprobe searches for radiogenic Mg-26, the decay product of Al-26 (t(sub 1/2) = 720,000 y). This has allowed estimates to be made of the time duration between CAI formation and the onset of Al-rich (and possibly, by extension, ferromagnesian) chondrule formation, on the order of 1.5-2.5 million years.
Evaluation of Title I CAI Programs at Minnesota State Correctional Institutions.
ERIC Educational Resources Information Center
Sandman, Richard S.; Welch, Wayne W.
Three Minnesota correctional institutions used computer-assisted instruction (CAI) on PLATO terminals to improve reading and mathematics skills: (1) the State Reformatory for Men, St. Cloud (males, ages 17-21); (2) the Minnesota Home School, Sauk Centre (males and females, ages 12-18); and (3) the State Training School, Red Wing (males, ages…
Role of Computer Assisted Instruction (CAI) in an Introductory Computer Concepts Course.
ERIC Educational Resources Information Center
Skudrna, Vincent J.
1997-01-01
Discusses the role of computer assisted instruction (CAI) in undergraduate education via a survey of related literature and specific applications. Describes an undergraduate computer concepts course and includes appendices of instructions, flowcharts, programs, sample student work in accounting, COBOL instructional model, decision logic in a…
Wu, Rina; Yu, Meiling; Liu, Xiaoyu; Meng, Lingshuai; Wang, Qianqian; Xue, Yating; Wu, Junrui; Yue, Xiqing
2015-10-15
We measured changes in the main physical and chemical properties, flavour compounds and microbial diversity in suan-cai during natural fermentation. The results showed that the pH and concentration of soluble protein initially decreased but were then maintained at a stable level; the concentration of nitrite increased in the initial fermentation stage and after reaching a peak it decreased significantly to a low level by the end of fermentation. Suan-cai was rich in 17 free amino acids. All of the free amino acids increased in concentration to different degrees, except histidine. Total free amino acids reached their highest levels in the mid-fermentation stage. The 17 volatile flavour components identified at the start of fermentation increased to 57 by the mid-fermentation stage; esters and aldehydes were in the greatest diversity and abundance, contributing most to the aroma of suan-cai. Bacteria were more abundant and diverse than fungi in suan-cai; 14 bacterial species were identified from the genera Leuconostoc, Bacillus, Pseudomonas and Lactobacillus. The predominant fungal species identified were Debaryomyces hansenii, Candida tropicalis and Penicillium expansum. Copyright © 2015 Elsevier B.V. All rights reserved.
NASA Technical Reports Server (NTRS)
Armstrong, J. T.; El Goresy, A.; Wasserburg, G. J.
1985-01-01
The structure and composition of Willy, a 150-micron-diameter Fremdling in CAI 5241 from the Allende meteorite, are investigated using optical, secondary-electron, and electron-backscatter microscopy and electron-microprobe analysis. The results are presented in diagrams, maps, tables, graphs, and micrographs and compared with those for other Allende Fremdlinge. Willy is found to have a concentric-zone structure comprising a complex porous core of magnetite, metal, sulfide, scheelite, and other minor phases; a compact magnetite-apatite mantle; a thin (20 microns or less) reaction-assemblage zone; and a dense outer rim of fassaite with minor spinel. A multistage formation sequence involving changes in T and fO2 and preceding the introduction of Willy into the CAI (which itself preceded CAI spinel and silicate formation) is postulated, and it is inferred from the apparent lack of post-capture recrystallization that Willy has not been subjected to temperatures in excess of 600 C and may represent the precursor material for many other Fremdlinge.
Computer-Assisted Instruction in Engineering Dynamics. CAI-Systems Memo Number 18.
ERIC Educational Resources Information Center
Sheldon, John W.
A 90-minute computer-assisted instruction (CAI) unit course supplemented by a 1-hour lecture on the dynamic nature of three-dimensional rotations and Euler angles was given to 29 undergraduate engineering students. The area of Euler angles was selected because it is essential to problem-working in three-dimensional rotations of a rigid body, yet…
Curanderismo in Taos County, New Mexico--a possible case of anthropological romanticism?
Scheper-Hughes, N; Stewart, D
1983-12-01
Interviews with 25 Spanish-Americans of Taos County, New Mexico, indicate that time and acculturation have greatly eroded the belief in and practice of curanderismo, the traditional folk medical system of the Southwest. Curanderismo in northern New Mexico today has moved from being a primary and important source of medical care to one used alternatively and very occasionally in cases of pediatric disorders, chronic illnesses and pain, and for those maladies still classified according to the traditional folk beliefs.
Web Pages: An Effective Method of Providing CAI Resource Material in Histology.
ERIC Educational Resources Information Center
McLean, Michelle
2001-01-01
Presents research that introduces computer-aided instruction (CAI) resource material as an integral part of the second-year histology course at the University of Natal Medical School. Describes the ease with which this software can be developed, using limited resources and available skills, while providing students with valuable learning…
1987-06-01
to a field of research called Computer-Aided Instruction (CAI). CAI is a powerful methodology for enhancing the overall quaiity and effectiveness of...provides a very powerful tool for statistical inference, especially when pooling informations from different source is appropriate. Thus. prior...04 , 2 ’ .. ."k, + ++ ,,;-+-,..,,..v ->’,0,,.’ I The power of the model lies in its ability to adapt a diagnostic session to the level of knowledge
NASA Astrophysics Data System (ADS)
Young, E. D.; Simon, J. I.; Galy, A.; Russell, S. S.; Tonui, E. K.; Lovera, O.
2005-03-01
We present new UV laser ablation and acid digestion MC-ICPMS analyses of 8 CAIs showing that there was more 26Al in the early solar system than previously thought, and that the canonical initial 26Al/27Al represents a ~300,000 yr residence time for CAIs in the protoplanetary disk.
NASA Astrophysics Data System (ADS)
Dunham, E.; Wadhwa, M.; Liu, M.-C.
2017-07-01
We report a more accurate range of initial 10Be/9Be in CAIs including FUN CAI CMS-1 from Allende (CV3) and a new CAI from NWA 5508 (CV3) using melilite composition glass standards; we suggest 10Be is largely produced by irradiation in the nebula.
Exploring Chondrule and CAI Rims Using Micro- and Nano-Scale Petrological and Compositional Analysis
NASA Astrophysics Data System (ADS)
Cartwright, J. A.; Perez-Huerta, A.; Leitner, J.; Vollmer, C.
2017-12-01
As the major components within chondrites, chondrules (mm-sized droplets of quenched silicate melt) and calcium-aluminum-rich inclusions (CAI, refractory) represent the most abundant and the earliest materials that solidified from the solar nebula. However, the exact formation mechanisms of these clasts, and whether these processes are related, remains unconstrained, despite extensive petrological and compositional study. By taking advantage of recent advances in nano-scale tomographical techniques, we have undertaken a combined micro- and nano-scale study of CAI and chondrule rim morphologies, to investigate their formation mechanisms. The target lithologies for this research are Wark-Lovering rims (WLR), and fine-grained rims (FGR) around CAIs and chondrules respectively, present within many chondrites. The FGRs, which are up to 100 µm thick, are of particular interest as recent studies have identified presolar grains within them. These grains predate the formation of our Solar System, suggesting FGR formation under nebular conditions. By contrast, WLRs are 10-20 µm thick, made of different compositional layers, and likely formed by flash-heating shortly after CAI formation, thus recording nebular conditions. A detailed multi-scale study of these respective rims will enable us to better understand their formation histories and determine the potential for commonality between these two phases, despite reports of an observed formation age difference of up to 2-3 Myr. We are using a combination of complimentary techniques on our selected target areas: 1) Micro-scale characterization using standard microscopic and compositional techniques (SEM-EBSD, EMPA); 2) Nano-scale characterization of structures using transmission electron microscopy (TEM) and elemental, isotopic and tomographic analysis with NanoSIMS and atom probe tomography (APT). Preliminary nano-scale APT analysis of FGR morphologies within the Allende carbonaceous chondrite has successfully discerned
Evaluation of a Text Compression Algorithm Against Computer-Aided Instruction (CAI) Material.
ERIC Educational Resources Information Center
Knight, Joseph M., Jr.
This report describes the initial evaluation of a text compression algorithm against computer assisted instruction (CAI) material. A review of some concepts related to statistical text compression is followed by a detailed description of a practical text compression algorithm. A simulation of the algorithm was programed and used to obtain…
Curanderismo in Taos County, New Mexico—A Possible Case of Anthropological Romanticism?
Scheper-Hughes, Nancy; Stewart, David
1983-01-01
Interviews with 25 Spanish-Americans of Taos County, New Mexico, indicate that time and acculturation have greatly eroded the belief in and practice of curanderismo, the traditional folk medical system of the Southwest. Curanderismo in northern New Mexico today has moved from being a primary and important source of medical care to one used alternatively and very occasionally in cases of pediatric disorders, chronic illnesses and pain, and for those maladies still classified according to the traditional folk beliefs. PMID:6666104
NASA Astrophysics Data System (ADS)
Pyszczek, R.; Mazuro, P.; Teodorczyk, A.
2016-09-01
This paper is focused on the CAI combustion control in a turbocharged 2-stroke Opposed-Piston (OP) engine. The barrel type OP engine arrangement is of particular interest for the authors because of its robust design, high mechanical efficiency and relatively easy incorporation of a Variable Compression Ratio (VCR). The other advantage of such design is that combustion chamber is formed between two moving pistons - there is no additional cylinder head to be cooled which directly results in an increased thermal efficiency. Furthermore, engine operation in a Controlled Auto-Ignition (CAI) mode at high compression ratios (CR) raises a possibility of reaching even higher efficiencies and very low emissions. In order to control CAI combustion such measures as VCR and water injection were considered for indirect ignition timing control. Numerical simulations of the scavenging and combustion processes were performed with the 3D CFD multipurpose AVL Fire solver. Numerous cases were calculated with different engine compression ratios and different amounts of directly and indirectly injected water. The influence of the VCR and water injection on the ignition timing and engine performance was determined and their application in the real engine was discussed.
Liu, Xin; Kuda, Takashi; Takahashi, Hajime; Kimura, Bon
2018-06-01
The Rubing milk cake from Yunnan and the Yan-cai vegetable pickles from Guangdong are traditional spontaneously fermented foods in China. We evaluated the microbial properties of these products with the analysis of their bacterial and fungal microbiota using classical culture-dependent and culture-independent methods, including a 16S rDNA gene (V4) and an internal transcribed spacer (ITS) region pyrosequencing method with MiSeq system. The viable lactic acid bacteria (LAB) count was 8 and 6 log colony-forming units (CFU)/g in Rubing and Yan-cai samples, respectively. The yeast count was approximately 100-1000 times less than the LAB count in most samples, except one Yan-cai sample. In addition, the gram-negative rod count in half of the samples was similar to the LAB count. Pyrosequencing results revealed the high abundance (10%-20%) of gram-negative Pseudomonas spp. and Enterobacteriaceae in these samples. These results suggest that some of these traditional foods are undesirable as ready-to-eat (RTE) foods, even when these are typical lactic acid fermented foods. Copyright © 2017 Elsevier Ltd. All rights reserved.
Phase relationships in the BaO-Ga2O3-Ta2O5 system and the structure of Ba6Ga21TaO40.
Cao, Jiang; Yu, Xiaodi; Kuang, Xiaojun; Su, Qiang
2012-07-16
Phase relationships in the BaO-Ga(2)O(3)-Ta(2)O(5) ternary system at 1200 °C were determined. The A(6)B(10)O(30) tetragonal tungsten bronze (TTB) related solution in the BaO-Ta(2)O(5) subsystem dissolved up to ~11 mol % Ga(2)O(3), forming a ternary trapezoid-shaped TTB-related solid solution region defined by the BaTa(2)O(6), Ba(1.1)Ta(5)O(13.6), Ba(1.58)Ga(0.92)Ta(4.08)O(13.16), and Ba(6)GaTa(9)O(30) compositions in the BaO-Ga(2)O(3)-Ta(2)O(5) system. Two ternary phases Ba(6)Ga(21)TaO(40) and eight-layer twinned hexagonal perovskite solid solution Ba(8)Ga(4-x)Ta(4+0.6x)O(24) were confirmed in the BaO-Ga(2)O(3)-Ta(2)O(5) system. Ba(6)Ga(21)TaO(40) crystallized in a monoclinic cell of a = 15.9130(2) Å, b = 11.7309(1) Å, c = 5.13593(6) Å, β = 107.7893(9)°, and Z = 1 in space group C2/m. The structure of Ba(6)Ga(21)TaO(40) was solved by the charge flipping method, and it represents a three-dimensional (3D) mixed GaO(4) tetrahedral and GaO(6)/TaO(6) octahedral framework, forming mixed 1D 5/6-fold tunnels that accommodate the Ba cations along the c axis. The electrical property of Ba(6)Ga(21)TaO(40) was characterized by using ac impedance spectroscopy.
A CBI Model for the Design of CAI Software by Teachers/Nonprogrammers.
ERIC Educational Resources Information Center
Tessmer, Martin; Jonassen, David H.
This paper describes a design model presented in workbook form which is intended to facilitate computer-assisted instruction (CAI) software design by teachers who do not have programming experience. Presentation of the model is preceded by a number of assumptions that underlie the instructional content and methods of the textbook. It is argued…
NASA Astrophysics Data System (ADS)
Barrett, Joan Beverly
Community colleges serve the most diverse student populations in higher education. They consist of non-traditional, part-time, older, intermittent, and mobile students of different races, ethnic backgrounds, language preferences, physical and mental abilities, and learning style preferences. Students who are academically challenged may have diverse learning characteristics that are not compatible with the more traditional approaches to the delivery of instruction. With this need come new ways of solving the dilemma, such as Computer-aided Instruction (CAI). This case study investigated the use of CAI as a laboratory component of college-level biology in a small, rural community college setting. The intent was to begin to fill a void that seems to exist in the literature regarding the role of the faculty in the development and use of CAI. In particular, the investigator was seeking to understand the practice and its effectiveness, especially in helping the under prepared student. The case study approach was chosen to examine a specific phenomenon within a single institution. Ethnographic techniques, such as interviewing, documentary analysis, life's experiences, and participant observations were used to collect data about the phenomena being studied. Results showed that the faculty was primarily self-motivated and self-taught in their use of CAI as a teaching and learning tool. The importance of faculty leadership and collegiality was evident. Findings showed the faculty confident that expectations of helping students who have difficulties with mathematical concepts have been met and that CAI is becoming the most valuable of learning tools. In a traditional college classroom, or practice, time is the constant (semesters) and competence is the variable. In the CAI laboratory time became the variable and competence the constant. The use of CAI also eliminated hazardous chemicals that were routinely used in the more traditional lab. Outcomes showed that annual savings
Microstructures of Hibonite From an ALH A77307 (CO3.0) CAI: Evidence for Evaporative Loss of Calcium
NASA Technical Reports Server (NTRS)
Han, Jangmi; Brearley, Adrian J.; Keller, Lindsay P.
2014-01-01
Hibonite is a comparatively rare, primary phase found in some CAIs from different chondrite groups and is also common in Wark-Lovering rims [1]. Hibonite is predicted to be one of the earliest refractory phases to form by equilibrium condensation from a cooling gas of solar composition [2] and, therefore, can be a potential recorder of very early solar system processes. In this study, we describe the microstructures of hibonite from one CAI in ALH A77307 (CO3.0) using FIB/TEM techniques in order to reconstruct its formational history.
NASA Technical Reports Server (NTRS)
Ito, M.; Messenger, S.; Walker, Robert M.
2007-01-01
Ca, Al-rich Inclusions (CAIs) preserve evidence of thermal events that they experienced during their formation in the early solar system. Most CAIs from CV and CO chondrites are characterized by large variations in O-isotopic compositions of primary minerals, with spinel, hibonite, and pyroxene being more O-16-rich than melilite and anorthite, with delta 17, O-18 = approx. -40%o (DELTA O-17 = delta O-17 - 0.52 x delta O-18 = approx. - 20%o ). These anomalous compositions cannot be accounted for by standard mass dependent fractionation and diffusive process of those minerals. It requires the presence of an anomalous oxygen reservoir of nucleosynthetic origin or mass independent fractionations before the formation of CAIs in the early solar system. The CAMECA NanoSIMS is a new generation ion microprobe that offers high sensitivity isotopic measurements with sub 100 nm spatial resolution. The NanoSIMS has significantly improved abilities in the study of presolar grains in various kind of meteorites and the decay products of extinct nuclides in ancient solar system matter. This instrument promises significant improvements over other conventional ion probes in the precision isotopic characterization of sub-micron scales. We report the results of our first O isotopic measurements of various CAI minerals from EK1-6-3 and 7R19-1(a) utilizing the JSC NanoSIMS 50L ion microprobe. We evaluate the measurement conditions, the instrumental mass fractionation factor (IMF) for O isotopic measurement and the accuracy of the isotopic ratio through the analysis of a San Carlos olivine standard and CAI sample of 7R19-1(a).
NASA Astrophysics Data System (ADS)
Dyl, K. A.; Young, E. D.
2009-12-01
We define the reaction space that controls changes in pyroxene composition in CAIs and Wark-Lovering (WL) rims in an oxidizing solar nebula. Ti-rich pyroxenes in CAIs record a sub-solar oxygen fugacity (Ti3+/Ti4+~1.5). WL rim pyroxenes in the CAI Leoville 144A have a distinctly lower oxidation state.This difference supports WL rim condensation in an environment of increasing O2(g) and Mg(g) (Simon et al. 2005). We used the following phase components to identify four linearly independent reactions (Thompson 1982): diopside, CaTs (Al2Mg-1Si-1), T3 (Ti3+AlMg-1Si-1), T4 (Ti4+Al2Mg-1Si-2), En (MgCa-1), perovskite, O(g), Mg(g), SiO(g), and Ca(g). Compositional variation in this system is dominated by two reactions. The first is oxidation of Ti3+ via reaction with O and Mg in the gas phase: 1.5 O(g) + Mg(g) → ¼ Di + [Ti4+Mg3/4Ti3+-1Ca-1/4Si-1/2] (1). Pyroxene is produced and En is introduced. The second reaction (2) is perovskite formation. It is observed in the WL rim of Leoville 144A, and experiments confirm that an elevated Ti component converts pyroxene to perovskite(Gupta et al. 1973). MgCa-1 is the third linearly independent reaction (3). They combine to give: ½ Di + x Ca(g)→ x Mg(g)+ Pv + [Mg1/2-xSiTi4+-1Ca-1/2+x](2,3). Unlike (1), pyroxene is consumed in this reaction. The parameter x defines the extent of Mg-Ca exchange. When x > 0.5, WL rim formation occurs in an environment where Mg is volatile and Ca condenses. The reaction space defined by reactions (1) and (2,3) describes the transition from CAI interior to WL rims. WL rim pyroxene Ti contents, [CaTs], and Ca < 1 pfu are all explained in this space. The fourth linearly independent reaction is SiO(g):1/8 Di + ¼ Mg(g)→ ¾ SiO(g) + [Mg3/8Ca1/8Ti4+Ti3+-1Si-1/2](4). Silica reduction forms Ti4+, releasing SiO(g). (4) does not describe the oxidation of Ti3+ in WL rim pyroxene, but (1) - (4) results in En formation directly from the gas phase. This may explain WL rim analyses that have Si contents in excess
CO-Bridged H-Cluster Intermediates in the Catalytic Mechanism of [FeFe]-Hydrogenase CaI
Ratzloff, Michael W.; Artz, Jacob H.; Mulder, David W.; ...
2018-05-23
The [FeFe]-hydrogenases ([FeFe] H 2ases) catalyze reversible H 2 activation at the H-cluster, which is composed of a [4Fe-4S] H subsite linked by a cysteine thiolate to a bridged, organometallic [2Fe-2S] ([2Fe] H) subsite. Profoundly different geometric models of the H-cluster redox states that orchestrate the electron/proton transfer steps of H 2 bond activation have been proposed. We have examined this question in the [FeFe] H 2ase I from Clostridium acetobutylicum (CaI) by Fourier-transform infrared (FTIR) spectroscopy with temperature annealing and H/D isotope exchange to identify the relevant redox states and define catalytic transitions. One-electron reduction of H ox ledmore » to formation of H redH + ([4Fe-4S] H 2+-Fe I-Fe I) and H red' ([4Fe-4S] H 1+-Fe II-Fe I), with both states characterized by low frequency μ-CO IR modes consistent with a fully bridged [2Fe] H. Similar μ-CO IR modes were also identified for H redH + of the [FeFe] H 2ase from Chlamydomonas reinhardtii (CrHydA1). The CaI proton-transfer variant C298S showed enrichment of an H/D isotope-sensitive μ-CO mode, a component of the hydride bound H-cluster IR signal, H hyd. Equilibrating CaI with increasing amounts of NaDT, and probed at cryogenic temperatures, showed H redH + was converted to H hyd. Over an increasing temperature range from 10 to 260 K catalytic turnover led to loss of Hhyd and appearance of H ox, consistent with enzymatic turnover and H 2 formation. The results show for CaI that the μ-CO of [2Fe] H remains bridging for all of the 'H red' states and that H redH + is on pathway to H hyd and H 2 evolution in the catalytic mechanism. Here, this provides a blueprint for designing small molecule catalytic analogs« less
CO-Bridged H-Cluster Intermediates in the Catalytic Mechanism of [FeFe]-Hydrogenase CaI
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ratzloff, Michael W.; Artz, Jacob H.; Mulder, David W.
The [FeFe]-hydrogenases ([FeFe] H 2ases) catalyze reversible H 2 activation at the H-cluster, which is composed of a [4Fe-4S] H subsite linked by a cysteine thiolate to a bridged, organometallic [2Fe-2S] ([2Fe] H) subsite. Profoundly different geometric models of the H-cluster redox states that orchestrate the electron/proton transfer steps of H 2 bond activation have been proposed. We have examined this question in the [FeFe] H 2ase I from Clostridium acetobutylicum (CaI) by Fourier-transform infrared (FTIR) spectroscopy with temperature annealing and H/D isotope exchange to identify the relevant redox states and define catalytic transitions. One-electron reduction of H ox ledmore » to formation of H redH + ([4Fe-4S] H 2+-Fe I-Fe I) and H red' ([4Fe-4S] H 1+-Fe II-Fe I), with both states characterized by low frequency μ-CO IR modes consistent with a fully bridged [2Fe] H. Similar μ-CO IR modes were also identified for H redH + of the [FeFe] H 2ase from Chlamydomonas reinhardtii (CrHydA1). The CaI proton-transfer variant C298S showed enrichment of an H/D isotope-sensitive μ-CO mode, a component of the hydride bound H-cluster IR signal, H hyd. Equilibrating CaI with increasing amounts of NaDT, and probed at cryogenic temperatures, showed H redH + was converted to H hyd. Over an increasing temperature range from 10 to 260 K catalytic turnover led to loss of Hhyd and appearance of H ox, consistent with enzymatic turnover and H 2 formation. The results show for CaI that the μ-CO of [2Fe] H remains bridging for all of the 'H red' states and that H redH + is on pathway to H hyd and H 2 evolution in the catalytic mechanism. Here, this provides a blueprint for designing small molecule catalytic analogs« less
CO-Bridged H-Cluster Intermediates in the Catalytic Mechanism of [FeFe]-Hydrogenase CaI.
Ratzloff, Michael W; Artz, Jacob H; Mulder, David W; Collins, Reuben T; Furtak, Thomas E; King, Paul W
2018-06-20
The [FeFe]-hydrogenases ([FeFe] H 2 ases) catalyze reversible H 2 activation at the H-cluster, which is composed of a [4Fe-4S] H subsite linked by a cysteine thiolate to a bridged, organometallic [2Fe-2S] ([2Fe] H ) subsite. Profoundly different geometric models of the H-cluster redox states that orchestrate the electron/proton transfer steps of H 2 bond activation have been proposed. We have examined this question in the [FeFe] H 2 ase I from Clostridium acetobutylicum (CaI) by Fourier-transform infrared (FTIR) spectroscopy with temperature annealing and H/D isotope exchange to identify the relevant redox states and define catalytic transitions. One-electron reduction of H ox led to formation of H red H + ([4Fe-4S] H 2+ -Fe I -Fe I ) and H red ' ([4Fe-4S] H 1+ -Fe II -Fe I ), with both states characterized by low frequency μ-CO IR modes consistent with a fully bridged [2Fe] H . Similar μ-CO IR modes were also identified for H red H + of the [FeFe] H 2 ase from Chlamydomonas reinhardtii (CrHydA1). The CaI proton-transfer variant C298S showed enrichment of an H/D isotope-sensitive μ-CO mode, a component of the hydride bound H-cluster IR signal, H hyd . Equilibrating CaI with increasing amounts of NaDT, and probed at cryogenic temperatures, showed H red H + was converted to H hyd . Over an increasing temperature range from 10 to 260 K catalytic turnover led to loss of H hyd and appearance of H ox , consistent with enzymatic turnover and H 2 formation. The results show for CaI that the μ-CO of [2Fe] H remains bridging for all of the "H red " states and that H red H + is on pathway to H hyd and H 2 evolution in the catalytic mechanism. These results provide a blueprint for designing small molecule catalytic analogs.
NASA Astrophysics Data System (ADS)
Cao, Li; Zhao, Hua; Jiang, Xi; Kalian, Navin
2006-02-01
The Controlled Auto-Ignition (CAI) combustion, also known as Homogeneous Charge Compression Ignition (HCCI), was achieved by trapping residuals with early exhaust valve closure in conjunction with direct injection. Multi-cycle 3D engine simulations have been carried out for parametric study on four different injection timings in order to better understand the effects of injection timings on in-cylinder mixing and CAI combustion. The full engine cycle simulation including complete gas exchange and combustion processes was carried out over several cycles in order to obtain the stable cycle for analysis. The combustion models used in the present study are the Shell auto-ignition model and the characteristic-time combustion model, which were modified to take the high level of EGR into consideration. A liquid sheet breakup spray model was used for the droplet breakup processes. The analyses show that the injection timing plays an important role in affecting the in-cylinder air/fuel mixing and mixture temperature, which in turn affects the CAI combustion and engine performance.
Everything You Always Wanted to Know About CAI But Were Afraid To Ask.
ERIC Educational Resources Information Center
Luskin, Bernard J.; And Others
A comprehensive summary of significant developments related to the integration of the computer in all levels of instruction, this book identifies, classifies, and examines obstacles to computer-assisted instruction (CAI), their scope and possible resolutions. Some 75 experts were surveyed and their opinions statistically analyzed in regard to 23…
Bridging East and West--Or, a Bridge Too Far? Paulo Freire and the "Tao Te Ching"
ERIC Educational Resources Information Center
Roberts, Peter
2012-01-01
This article considers key differences and similarities between Freirean and Taoist ideals. I limit my focus to the "Tao Te Ching" (attributed to Lao Tzu), paying brief attention to the origins of this classic work of Chinese philosophy before concentrating on several themes of relevance to Freire's work. An essay by James Fraser (1997), who makes…
Thermal maturity patterns in New York State using CAI and %Ro
Weary, D.J.; Ryder, R.T.; Nyahay, R.E.
2001-01-01
New conodont alteration index (CAI) and vitrinite reflectance (%Ro) data collected from drill holes in the Appalachian basin of New York State allow refinement of thermal maturity maps for Ordovician and Devonian rocks. CAI isotherms on the new maps show a pattern that approximates that published by Harris et al. (1978) in eastern and western New York, but it differs in central New York, where the isotherms are shifted markedly westward by more than 100 km and are more tightly grouped. This close grouping of isograds reflects a steeper thermal gradient than previously noted by Harris et al. (1978) and agrees closely with the abrupt west-to-east increase in thermal maturity across New York noted by Johnsson (1986). These data show, in concordance with previous studies, that thermal maturity levels in these rocks are higher than can be explained by simple burial heating beneath the present thickness of overburden. The Ordovician and Devonian rocks of the Appalachian Basin in New York must have been buried by very thick post-Devonian sediments (4-6 km suggested by Sarwar and Friedman 1995) or were exposed to a higher-than-normal geothermal flux caused by crustal extension, or a combination of the two.
NASA Technical Reports Server (NTRS)
Brown, Laurie L.; Caffall, Nancy M.; Golombek, Matthew P.
1993-01-01
The tectonic response of the Taos Plateau volcanic field in the southern San Luis basin to the late stage extensional environment of the Rio Grande rift was investigated using paleomagnetic techniques. Sixty-two sites (533 samples) of Pliocene volcanic units were collected covering four major rock types with ages of 4.7 to 1.8 Ma. Twenty-two of these sites were from stratigraphic sections of the lower, middle and upper Servilleta Basalt collected in the Rio Grande gorge at two locations 19 km apart. Flows from the lower and middle members in the southern gorge record reversed polarities, while those in Garapata Canyon are normal with an excursion event in the middle of the sequence. The uppermost flows of the upper member at both sites display normal directions. Although these sections correlate chemically, they seem to represent different magnetic time periods during the Gilbert Reversed-Polarity Chiron. Alternating field demagnetization, aided by principal component analysis, yields 55 sites with stable directions representing both normal and reversed polarities, and five sites indicating transitional fields. Mean direction of the normal and inverted reversed sites is I=49.3 deg. and D=356.7 deg. (alpha(sub 95)=3.6 deg). Angular dispersion of the virtual geomagnetic poles is 16.3 deg, which is consistent with paleosecular variation model G, fit to data from the past 5 m.y. Comparison with the expected direction indicates no azimuthal rotation of the Taos Plateau volcanic field; inclination flattening for the southern part of the plateau is 8.3 deg +/- 5.3 deg. Previous paleomagnelic data indicate 10 deg- 15 deg counterclockwise rotation of die Espanola block to the south over the past 5 m.y. The data suggest the Taos Plateau volcanic field, showing no rotation and some flattening in the south and east, has acted as a stable buttress and has been downwarped by overriding of the southeastern end of the plateau by the Picuris Mountains, which make up the northern
1980-06-01
courseware package on how to program lessons for an automated system. Since PLANIT (Programming Language for Interactive Teaching) is the student/author...assisted instruction (CAI), how to program PLANIT lessons, and to evaluate the effectiveness of the package for select Army users. The resultant courseware
[Analysis on professor WANG Juyi's crevice theory from Tao Teh King].
Luo, Lu; Wang, Juyi
2015-10-01
The crevice theory proposed by professor WANG Juyi is analyzed in this article. In the crevice theory, it is believed that the meridians are located among "skin, pulse, flesh, tendon and bone", and the crevice is the path for the transportation of qi-blood and body fluid in the body, which is the essential condition for vital movement. This is in agreement with the idea of "action through inaction" from Tao Teh King. Based on crevice theory, the abnormalities of meridians can reflex the deficiency and excess of diseases, and regulating meridians is a significant way to treat diseases, and maintaining smooth meridian is important for healthcare.
ERIC Educational Resources Information Center
Kausar, Tayyaba; Choudhry, Bushra Naoreen; Gujjar, Aijaz Ahmed
2008-01-01
This study was aimed to evaluate the effectiveness of CAI vs. classroom lecture for computer science at ICS level. The objectives were to compare the learning effects of two groups with class room lecture and computer assisted instruction studying the same curriculum and the effects of CAI and CRL in terms of cognitive development. Hypothesis of…
ERIC Educational Resources Information Center
Kausar, Tayyaba; Choudhry, Bushra Naoreen; Gujjar, Aijaz Ahmed
2008-01-01
This study was aimed to evaluate the effectiveness of CAI vs. classroom lecture for computer science at ICS level. The objectives were to compare the learning effects of two groups with class room lecture and computer assisted instruction studying the same curriculum and the effects of CAI and CRL in terms of cognitive development. Hypothesis of…
NASA Astrophysics Data System (ADS)
Hashimoto, M.; Kuze, A.; Bruegge, C. J.; Shiomi, K.; Kataoka, F.; Kikuchi, N.; Arai, T.; Kasai, K.; Nakajima, T.
2016-12-01
The GOSAT (Greenhouse Gases Observing Satellite) / TANSO-CAI (Cloud and Aerosol Imager, CAI) is an imaging sensor to measure cloud and aerosol properties and observes reflected sunlight from the atmosphere and surface of the ground. The sensor has four bands from near ultraviolet (near-UV) to shortwave infrared, 380, 674, 870 and 1600nm. The field of view size is 0.5 km for band-1 through band-3, and 1.5km for band-4. Band-1 (380nm) is one of unique function of the CAI. The near-UV observation offers several advantages for the remote sensing of aerosols over land: Low reflectance of most surfaces; Sensitivity to absorbing aerosols; Absorption of trace gases is weak (Höller et al., 2004). CAI UV-band is useful to distinguish absorbing aerosol (smoke) from cloud. GOSAT-2/TANSO-CAI-2 that will be launched in the future also has UV-bands, 340 and 380nm. We carried out an experiment to calibrate CAI UV-band radiance using data taken in a field campaign of OCO-2 and GOSAT at Railroad Valley in 2016. The campaign period is June 27 to July 3 in 2016. We measured surface reflectance by using USB4000 Spectrometer with 74-UV collimating lens (Ocean Optics) and Spectralon (Labsphere). USB4000 is a UV spectrometer, and its measurement range from 300 to 520nm. We simulated CAI UV-band radiance using a vector type of radiation transfer code, i.e. including polarization calculation, pstar3 (Ota et al., 2010) using measured surface reflectance and atmospheric data, pressure and relative humidity by radiosonde in the same campaign, and aerosol optical depth by AERONET, etc. Then, we evaluated measured UV radiances with the simulated data. We show the result of vicarious calibration of CAI UV-band in the campaign, and discuss about this method for future sensor, CAI-2. Around the campaign period, there was wildfire around Los Angeles, and aerosol optical thickness (AOT) observed by AERONET at Rail Road valley and Caltech sites is also high. We tried to detect and retrieve aerosol
Zanatta, Melina Borges Teixeira; Nakadi, Flávio Venâncio; da Veiga, Márcia Andreia Mesquita Silva
2018-03-01
A new method to determine iodine in drug samples by high-resolution continuum source graphite furnace molecular absorption spectrometry (HR-CS GF MAS) has been developed. The method measures the molecular absorption of a diatomic molecule, CaI or SrI (less toxic molecule-forming reagents), at 638.904 or 677.692nm, respectively, and uses a mixture containing 5μg of Pd and 0.5μg of Mg as chemical modifier. The method employs pyrolysis temperatures of 1000 and 800°C and vaporization temperatures of 2300 and 2400°C for CaI and SrI, respectively. The optimized amounts of Ca and Sr as molecule-forming reagents are 100 and 150µg, respectively. On the basis of interference studies, even small chlorine concentrations reduce CaI and SrI absorbance significantly. The developed method was used to analyze different commercial drug samples, namely thyroid hormone pills with three different iodine amounts (15.88, 31.77, and 47.66µg) and one liquid drug with 1% m v -1 active iodine in their compositions. The results agreed with the values informed by the manufacturers (95% confidence level) regardless of whether CaI or SrI was determined. Therefore, the developed method is useful for iodine determination on the basis of CaI or SrI molecular absorption. Copyright © 2017 Elsevier B.V. All rights reserved.
A Cross-National CAI Tool To Support Learning Operations Decision-Making and Market Analysis.
ERIC Educational Resources Information Center
Mockler, Robert J.; Afanasiev, Mikhail Y.; Dologite, Dorothy G.
1999-01-01
Describes bicultural (United States and Russia) development of a computer-aided instruction (CAI) tool to learn management decision-making using information systems technologies. The program has been used with undergraduate and graduate students in both countries; it integrates free and controlled market concepts and combines traditional computer…
Quantum Computational Universality of the 2D Cai-Miyake-D"ur-Briegel Quantum State
NASA Astrophysics Data System (ADS)
Wei, Tzu-Chieh; Raussendorf, Robert; Kwek, Leong Chuan
2012-02-01
Universal quantum computation can be achieved by simply performing single-qubit measurements on a highly entangled resource state, such as cluster states. Cai, Miyake, D"ur, and Briegel recently constructed a ground state of a two-dimensional quantum magnet by combining multiple Affleck-Kennedy-Lieb-Tasaki quasichains of mixed spin-3/2 and spin-1/2 entities and by mapping pairs of neighboring spin-1/2 particles to individual spin-3/2 particles [Phys. Rev. A 82, 052309 (2010)]. They showed that this state enables universal quantum computation by constructing single- and two-qubit universal gates. Here, we give an alternative understanding of how this state gives rise to universal measurement-based quantum computation: by local operations, each quasichain can be converted to a one-dimensional cluster state and entangling gates between two neighboring logical qubits can be implemented by single-spin measurements. Furthermore, a two-dimensional cluster state can be distilled from the Cai-Miyake-D"ur-Briegel state.
NASA Technical Reports Server (NTRS)
Simon, J. I.; Jordan, M. K.; Tappa, M. J.; Kohl, I. E.; Young, E. D.
2016-01-01
The chemical and isotopic compositions of calcium-aluminum-rich inclusions (CAIs) can be used to understand the conditions present in the protoplantary disk where they formed. The isotopic compositions of these early-formed nebular materials are largely controlled by chemical volatility. The isotopic effects of evaporation/sublimation, which are well explained by both theory and experimental work, lead to enrichments of the heavy isotopes that are often exhibited by the moderately refractory elements Mg and Si. Less well understood are the isotopic effects of condensation, which limits our ability to determine whether a CAI is a primary condensate and/or retains any evidence of its primordial formation history.
Cushion, Christopher; Harvey, Stephen; Muir, Bob; Nelson, Lee
2012-01-01
We outline the evolution of a computerised systematic observation tool and describe the process for establishing the validity and reliability of this new instrument. The Coach Analysis and Interventions System (CAIS) has 23 primary behaviours related to physical behaviour, feedback/reinforcement, instruction, verbal/non-verbal, questioning and management. The instrument also analyses secondary coach behaviour related to performance states, recipient, timing, content and questioning/silence. The CAIS is a multi-dimensional and multi-level mechanism able to provide detailed and contextualised data about specific coaching behaviours occurring in complex and nuanced coaching interventions and environments that can be applied to both practice sessions and competition.
NASA Technical Reports Server (NTRS)
Brown, Laurie L.; Caffall, Nancy M.; Golombek, Matthew P.
1993-01-01
The tectonic response of the Taos Plateau volcanic field in the southern San Luis basin to late stage extensional environment of the Rio Grande rift was investigate using paleomagnetic techniques. Sixty-two sites (533 samples) of Pliocene volcanic units were collected covering four major rock types with ages of 4.7 to 1.8 Ma. Twenty-two of these sites were from stratigraphic sections of the lower, middle and upper Servilleta Basalt collected in the Rio Grande gorge at two locations 19 km apart. Flows from the lower and middle members in the southern gorge record reversed polarities, while those in Garapata Canyon are normal with an excursion event in the middle of the sequence. The uppermost flows of the upper member at both sites display normal directions. Although these sections correlate chemically, they seem to represent different magnetic time periods during the Gilbert Reversed-Polarity Chron. The data suggest the Taos Plateau volcanic field, showing no rotation and some flattening in the south and east, has acted as a stable buttress and has been downwarped by overriding of the southeastern end of the plateau by the Picuris Mountains, which make up the northern corner of the counter-clockwise rotating Espanola block.
NASA Astrophysics Data System (ADS)
Brown, Laurie L.; Caffall, Nancy M.; Golombek, Matthew P.
1993-12-01
The tectonic response of the Taos Plateau volcanic field in the southern San Luis basin to late stage extensional environment of the Rio Grande rift was investigate using paleomagnetic techniques. Sixty-two sites (533 samples) of Pliocene volcanic units were collected covering four major rock types with ages of 4.7 to 1.8 Ma. Twenty-two of these sites were from stratigraphic sections of the lower, middle and upper Servilleta Basalt collected in the Rio Grande gorge at two locations 19 km apart. Flows from the lower and middle members in the southern gorge record reversed polarities, while those in Garapata Canyon are normal with an excursion event in the middle of the sequence. The uppermost flows of the upper member at both sites display normal directions. Although these sections correlate chemically, they seem to represent different magnetic time periods during the Gilbert Reversed-Polarity Chron. The data suggest the Taos Plateau volcanic field, showing no rotation and some flattening in the south and east, has acted as a stable buttress and has been downwarped by overriding of the southeastern end of the plateau by the Picuris Mountains, which make up the northern corner of the counter-clockwise rotating Espanola block.
Miao, Edwin Yong; Miao, Miranda Yi-mo; Kildea, Daniel George; Lao, Yi-Wen
2014-02-01
This study investigated the efficacies of electroacupuncture and electroacupuncture combined with Tao Hong Si Wu Wan in treating primary dysmenorrhea and compared the results with those obtained using conventional medical treatment. One treatment group, group 1, was administered Tao Hong Si Wu Wan (2625 mg) while the other, group 2, was administered a placebo (2625 mg) twice daily for 3 months. Electroacupuncture was used in both treatment groups: two sessions per menstrual cycle for three menstrual cycles. The reference group, group 3, was administered ibuprofen, 600 mg, twice daily, for five menstrual cycles. Uses of the herb, placebo and ibuprofen were blinded. A ridit analysis was used for testing and interpreting the effects of treatment. Pain intensity was determined using a qualitative grading method in a blinded manner. The ridit scores in groups 1 and 2 were significantly higher than those in reference group immediately after treatment and three months later. Twelve months after the treatment, group 1 had a higher ridit score than group 2. In comparison to the reference group, groups 1 and 2 achieved better menstrual pain relief both immediately and 3 months after treatment. In addition, group 1 had better long-term pain relief than group 2. Copyright © 2014. Published by Elsevier B.V.
An experimental study of fuel injection strategies in CAI gasoline engine
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hunicz, J.; Kordos, P.
2011-01-15
Combustion of gasoline in a direct injection controlled auto-ignition (CAI) single-cylinder research engine was studied. CAI operation was achieved with the use of the negative valve overlap (NVO) technique and internal exhaust gas re-circulation (EGR). Experiments were performed at single injection and split injection, where some amount of fuel was injected close to top dead centre (TDC) during NVO interval, and the second injection was applied with variable timing. Additionally, combustion at variable fuel-rail pressure was examined. Investigation showed that at fuel injection into recompressed exhaust fuel reforming took place. This process was identified via an analysis of the exhaust-fuelmore » mixture composition after NVO interval. It was found that at single fuel injection in NVO phase, its advance determined the heat release rate and auto-ignition timing, and had a strong influence on NO{sub X} emission. However, a delay of single injection to intake stroke resulted in deterioration of cycle-to-cycle variability. Application of split injection showed benefits of this strategy versus single injection. Examinations of different fuel mass split ratios and variable second injection timing resulted in further optimisation of mixture formation. At equal share of the fuel mass injected in the first injection during NVO and in the second injection at the beginning of compression, the lowest emission level and cyclic variability improvement were observed. (author)« less
NASA Astrophysics Data System (ADS)
Park, Changkun; Nagashima, Kazuhide; Krot, Alexander N.; Huss, Gary R.; Davis, Andrew M.; Bizzarro, Martin
2017-03-01
Calcium-aluminum-rich inclusions with isotopic mass fractionation effects and unidentified nuclear isotopic anomalies (FUN CAIs) have been studied for more than 40 years, but their origins remain enigmatic. Here we report in situ high precision measurements of aluminum-magnesium isotope systematics of FUN CAIs by secondary ion mass spectrometry (SIMS). Individual minerals were analyzed in six FUN CAIs from the oxidized CV3 carbonaceous chondrites Axtell (compact Type A CAI Axtell 2271) and Allende (Type B CAIs C1 and EK1-4-1, and forsterite-bearing Type B CAIs BG82DH8, CG-14, and TE). Most of these CAIs show evidence for excess 26Mg due to the decay of 26Al. The inferred initial 26Al/27Al ratios [(26Al/27Al)0] and the initial magnesium isotopic compositions (δ26Mg0) calculated using an exponential law with an exponent β of 0.5128 are (3.1 ± 1.6) × 10-6 and 0.60 ± 0.10‰ (Axtell 2271), (3.7 ± 1.5) × 10-6 and -0.20 ± 0.05‰ (BG82DH8), (2.2 ± 1.1) × 10-6 and -0.18 ± 0.05‰ (C1), (2.3 ± 2.4) × 10-5 and -2.23 ± 0.37‰ (EK1-4-1), (1.5 ± 1.1) × 10-5 and -0.42 ± 0.08‰ (CG-14), and (5.3 ± 0.9) × 10-5 and -0.05 ± 0.08‰ (TE) with 2σ uncertainties. We infer that FUN CAIs recorded heterogeneities of magnesium isotopes and 26Al in the CAI-forming region(s). Comparison of 26Al-26Mg systematics, stable isotope (oxygen, magnesium, calcium, and titanium) and trace element studies of FUN and non-FUN igneous CAIs indicates that there is a continuum among these CAI types. Based on these observations and evaporation experiments on CAI-like melts, we propose a generic scenario for the origin of igneous (FUN and non-FUN) CAIs: (i) condensation of isotopically normal solids in an 16O-rich gas of approximately solar composition; (ii) formation of CAI precursors by aggregation of these solids together with variable abundances of isotopically anomalous grains-possible carriers of unidentified nuclear (UN) effects; and (iii) melt evaporation of these precursors
ERIC Educational Resources Information Center
Lansford, Carl E.
As computer aided instruction (CAI) and distance learning become more popular, a model for easily evaluating these teaching methods must be developed, one which will enable replication of the study each year. This paper discusses the results of a study using existing dependent and independent variables to evaluate CAI for developmental reading…
Mueller, S C; Verwilst, T; Van Branteghem, A; T'Sjoen, G; Cools, M
2016-02-01
Few studies have examined the impact of androgen insensitivity on human spatial learning and memory. In the present study, we tested 11 women with complete androgen insensitivity syndrome (CAIS), a rare genetic disorder characterized by complete absence of AR activity, and compared their performance against 20 comparison males and 19 comparison females on a virtual analog of the Morris Water Maze task. The results replicated a main sex effect showing that men relative to women were faster in finding the hidden platform and had reduced heading error. Furthermore, findings indicated that mean performance of women with CAIS was between control women and control men, though the differences were not statistically significant. Effect size estimates (and corresponding confidence intervals) of spatial learning trials showed little difference between women with CAIS and control women but CAIS women differed from men, but not women, on two variables, latency to find the platform and first-move latency. No differences between groups were present during visible platform trials or the probe trial, a measure of spatial memory. Moreover, groups also did not differ on estimates of IQ and variability of performance. The findings are discussed in relation to androgen insensitivity in human spatial learning and memory. Copyright © 2015 Elsevier Inc. All rights reserved.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-17
... Tests for Inclusion in the Program AGENCY: National Institute of Standards and Technology (NIST... meeting is to present the final requirements for CAI conventional conformance tests for inclusion in the... suitability for inclusion in the P25 CAP is below: Conformance tests should limit devices in the test...
This report documents the activities performed and the results obtained for the EPA arsenic removal technology demonstration project at the Town of Taos in New Mexico. The main objective of the project was to evaluate the effectiveness of Severn Trent Services’ (STS) SORB 33™ ad...
NASA Astrophysics Data System (ADS)
Liu, J.; Kou, L.
2015-12-01
Abstract: The changes of both climate and land use/cover have some impact on the water resources. For Tao'er River Basin, these changes have a direct impact on the land use pattern adjustment, wetland protection, connection project between rivers and reservoirs, local social and economic development, etc. Therefore, studying the impact of climate and land use/cover changes is of great practical significance. The Soil and Water Assessment Tool (SWAT) is used as the research method. With historical actual measured runoff data and the yearly land use classification caught by satellite remote sensing maps, analyze the impact of climate change on the runoff of Tao'er River. And according to the land use/cover classification of 1990, 2000 and 2010, analyze the land use/cover change in the recent 30 years, the impact of the land use/cover change on the river runoff and the contribution coefficient of farmland, woodland, grassland and other major land-use types to the runoff. These studies can provide some references to the rational allocation of water resource and adjustment of land use structure in this area.
NASA Astrophysics Data System (ADS)
Kööp, Levke; Davis, Andrew M.; Nakashima, Daisuke; Park, Changkun; Krot, Alexander N.; Nagashima, Kazuhide; Tenner, Travis J.; Heck, Philipp R.; Kita, Noriko T.
2016-09-01
PLACs (platy hibonite crystals) and related hibonite-rich calcium-, aluminum-rich inclusions (CAIs; hereafter collectively referred to as PLAC-like CAIs) have the largest nucleosynthetic isotope anomalies of all materials believed to have formed in the solar system. Most PLAC-like CAIs have low inferred initial 26Al/27Al ratios and could have formed prior to injection or widespread distribution of 26Al in the solar nebula. In this study, we report 26Al-26Mg systematics combined with oxygen, calcium, and titanium isotopic compositions for a large number of newly separated PLAC-like CAIs from the Murchison CM2 chondrite (32 CAIs studied for oxygen, 26 of these also for 26Al-26Mg, calcium and titanium). Our results confirm (1) the large range of nucleosynthetic anomalies in 50Ti and 48Ca (our data range from -70‰ to +170‰ and -60‰ to +80‰, respectively), (2) the substantial range of Δ17O values (-28‰ to -17‰, with Δ17O = δ17O - 0.52 × δ18O), and (3) general 26Al-depletion in PLAC-like CAIs. The multielement approach reveals a relationship between Δ17O and the degree of variability in 50Ti and 48Ca: PLAC-like CAIs with the highest Δ17O (∼-17‰) show large positive and negative 50Ti and 48Ca anomalies, while those with the lowest Δ17O (∼-28‰) have small to no anomalies in 50Ti and 48Ca. These observations could suggest a physical link between anomalous 48Ca and 50Ti carriers and an 16O-poor reservoir. We suggest that the solar nebula was isotopically heterogeneous shortly after collapse of the protosolar molecular cloud, and that the primordial dust reservoir, in which anomalous carrier phases were heterogeneously distributed, was 16O-poor (Δ17O ⩾ -17‰) relative to the primordial gaseous (CO + H2O) reservoir (Δ17O < -35‰). However, other models such as CO self-shielding in the protoplanetary disk are also considered to explain the link between oxygen and calcium and titanium isotopes in PLAC-like CAIs.
Electronic Properties of Cyclacenes from TAO-DFT
Wu, Chun-Shian; Lee, Pei-Yin; Chai, Jeng-Da
2016-01-01
Owing to the presence of strong static correlation effects, accurate prediction of the electronic properties (e.g., the singlet-triplet energy gaps, vertical ionization potentials, vertical electron affinities, fundamental gaps, symmetrized von Neumann entropy, active orbital occupation numbers, and real-space representation of active orbitals) of cyclacenes with n fused benzene rings (n = 4–100) has posed a great challenge to traditional electronic structure methods. To meet the challenge, we study these properties using our newly developed thermally-assisted-occupation density functional theory (TAO-DFT), a very efficient method for the study of large systems with strong static correlation effects. Besides, to examine the role of cyclic topology, the electronic properties of cyclacenes are also compared with those of acenes. Similar to acenes, the ground states of cyclacenes are singlets for all the cases studied. In contrast to acenes, the electronic properties of cyclacenes, however, exhibit oscillatory behavior (for n ≤ 30) in the approach to the corresponding properties of acenes with increasing number of benzene rings. On the basis of the calculated orbitals and their occupation numbers, the larger cyclacenes are shown to exhibit increasing polyradical character in their ground states, with the active orbitals being mainly localized at the peripheral carbon atoms. PMID:27853249
Grauch, V.J.S.; Bauer, Paul W.; Drenth, Benjamin J.; Kelson, Keith I.
2017-01-01
We present a detailed example of how a subbasin develops adjacent to a transfer zone in the Rio Grande rift. The Embudo transfer zone in the Rio Grande rift is considered one of the classic examples and has been used as the inspiration for several theoretical models. Despite this attention, the history of its development into a major rift structure is poorly known along its northern extent near Taos, New Mexico. Geologic evidence for all but its young rift history is concealed under Quaternary cover. We focus on understanding the pre-Quaternary evidence that is in the subsurface by integrating diverse pieces of geologic and geophysical information. As a result, we present a substantively new understanding of the tectonic configuration and evolution of the northern extent of the Embudo fault and its adjacent subbasin.We integrate geophysical, borehole, and geologic information to interpret the subsurface configuration of the rift margins formed by the Embudo and Sangre de Cristo faults and the geometry of the subbasin within the Taos embayment. Key features interpreted include (1) an imperfect D-shaped subbasin that slopes to the east and southeast, with the deepest point ∼2 km below the valley floor located northwest of Taos at ∼36° 26′N latitude and 105° 37′W longitude; (2) a concealed Embudo fault system that extends as much as 7 km wider than is mapped at the surface, wherein fault strands disrupt or truncate flows of Pliocene Servilleta Basalt and step down into the subbasin with a minimum of 1.8 km of vertical displacement; and (3) a similar, wider than expected (5–7 km) zone of stepped, west-down normal faults associated with the Sangre de Cristo range front fault.From the geophysical interpretations and subsurface models, we infer relations between faulting and flows of Pliocene Servilleta Basalt and older, buried basaltic rocks that, combined with geologic mapping, suggest a revised rift history involving shifts in the locus of fault activity as
ERIC Educational Resources Information Center
Rowland, Paul McD.
The effect of mode of computer-assisted instruction (CAI) and individual learning differences on the learning of science concepts was investigated. University elementary education majors learned about home energy use from either a computer simulation or a computer tutorial. Learning of science concepts was measured using achievement and…
The effect of different oxygen exchange layers on TaO x based RRAM devices
NASA Astrophysics Data System (ADS)
Alamgir, Zahiruddin; Holt, Joshua; Beckmann, Karsten; Cady, Nathaniel C.
2018-01-01
In this work, we investigated the effect of the oxygen exchange layer (OEL) on the resistive switching properties of TaO x based memory cells. It was found that the forming voltage, SET-RESET voltage, R off, R on and retention properties are strongly correlated with the oxygen scavenging ability of the OEL, and the resulting oxygen vacancy formation ability of this layer. Higher forming voltage was observed for OELs having lower electronegativity/lower Gibbs free energy for oxide formation, and devices fabricated with these OELs exhibited an increased memory window, when using similar SET-RESET voltage range.
A FIB/TEM/Nanosims Study of a Wark-Lovering Rim on an Allende CAI
NASA Technical Reports Server (NTRS)
Keller, L. P.; Needham, A. W.; Messenger, S.
2014-01-01
Ca- Al-rich inclusions (CAIs) are commonly surrounded by Wark-Lovering (WL) rims - thin (approx. 50 micrometers) multilayered sequences - whose mineralogy is dominated by high temperature minerals similar to those that occur in the cores of CAIs [1]. The origins of these WL rims involved high temperature events in the early nebula such as condensation, flashheating or reaction with a nebular reservoir, or combinations of these processes. These rims formed after CAI formation but prior to accretion into their parent bodies. We have undertaken a coordinated mineralogical and isotopic study of WL rims to determine the formation conditions of the individual layers and to constrain the isotopic reservoirs they interacted with during their history. We focus here on the spinel layer, the first-formed highest- temperature layer in the WL rim sequence. Results and Discussion: We have performed mineralogical, chemical and isotopic analyses of an unusual ultrarefractory inclusion from the Allende CV3 chondrite (SHAL) consisting of an approx. 500 micrometers long single crystal of hibonite and co-existing coarsegrained perovskite. SHAL is partially surrounded by WL rim. We previously reported on the mineralogy, isotopic compositions and trace elements in SHAL [2-4]. The spinel layer in the WL rim is present only on the hibonite and terminates abruptly at the contact with the coarse perovskite. This simple observation shows that the spinel layer is not a condensate in this case (otherwise spinel would have condensed on the perovskite as well). The spinel layer appears to have formed by gas-phase corrosion of the hibonite by Mg-rich vapors such that the spinel layer grew at the expense of the hibonite. We also found that the spinel layer has the same 16Orich composition as the hibonite. The spinel layer is polycrystalline and individual crystals do not show a crystallographic relationship with the hibonite. An Al-diopside layer overlies the spinel layer, and is present on both
Moncayo, Roy; Moncayo, Helga
2007-01-01
Background Low level connective tissue inflammation has been proposed to play a role in thyroid associated ophthalmopathy (TAO). The aim of this study was to investigate this postulate by a musculoskeletal approach together with biochemical parameters. Methods 13 patients with TAO and 16 controls were examined. Erythrocyte levels of Zn, Cu, Ca2+, Mg, and Fe were determined. The musculoskeletal evaluation included observational data on body posture with emphasis on the orbit-head region. The angular foot position in the frontal plane was quantified following gait observation. The axial orientation of the legs and feet was evaluated in an unloaded supine position. Functional propioceptive tests based on stretch stimuli were done by using foot inversion and foot rotation. Results Alterations in the control group included neck tilt in 3 cases, asymmetrical foot angle during gait in 2, and a reaction to foot inversion in 5 cases. TAO patients presented facial asymmetry with displaced eye fissure inclination (mean 9.1°) as well as tilted head-on-neck position (mean 5.7°). A further asymmetry feature was external rotation of the legs and feet (mean 27°). Both foot inversion as well as foot rotation induced a condition of neuromuscular deficit. This condition could be regulated by gentle acupressure either on the lateral abdomen or the lateral ankle at the acupuncture points gall bladder 26 or bladder 62, respectively. In 5 patients, foot rotation produced a phenomenon of moving toes in the contra lateral foot. In addition foot rotation was accompanied by an audible tendon snapping. Lower erythrocyte Zn levels and altered correlations between Ca2+, Mg, and Fe were found in TAO. Conclusion This whole body observational study has revealed axial deviations and body asymmetry as well as the phenomenon of moving toes in TAO. The most common finding was an arch-like displacement of the body, i.e. eccentric position, with foot inversion and head tilt to the contra lateral side
Groundwater Flow Model for Taos, New Mexico
NASA Astrophysics Data System (ADS)
Burck, P. W.; Barroll, P. W.; Core, A. B.; Rappuhn, D.
2003-12-01
The New Mexico Office of the State Engineer - Hydrology Bureau (OSE) has developed a regional groundwater flow model for Taos, New Mexico. The MODFLOW 2000 model will serve as a tool to evaluate alternatives in settlement negotiations in an on-going water rights adjudication. If current settlement negotiations fail, it is conceivable that the model might be used in support of litigation. OSE produced the model in cooperation with technical representatives of the various parties to the adjudication. Regional hydrogeologic data including well records, aquifer test results, stream flow measurements and seepage studies have been shared relatively freely among the parties. A recent deep drilling program conducted in conjunction with the negotiation effort has added substantially to the hydrogeologic data set. Among the hydrologic processes simulated by the model are mountain front recharge; areal recharge from precipitation; evapotranspiration; discharge from springs; river and stream flow; accretions to groundwater from irrigation return flow, seepage from acequias, canals, and ditches, and deep percolation; and pumping by municipal entities and mutual domestic water users associations. The resulting model files are available for all parties to review and evaluate. Comments are assessed and many have resulted in significant improvements to the model. At this stage, however, it is unclear whether adopting this cooperative approach will increase the likelihood of model acceptance by the parties.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lee, C.H.; Lee, K.H.
2007-08-15
Emissions remain a critical issue affecting engine design and operation, while energy conservation is becoming increasingly important. One approach to favorably address these issues is to achieve homogeneous charge combustion and stratified charge combustion at lower peak temperatures with a variable compression ratio, a variable intake temperature and a trapped rate of the EGR using NVO (negative valve overlap). This experiment was attempted to investigate the origins of these lower temperature auto-ignition phenomena with SCCI and CAI using gasoline fuel. In case of SCCI, the combustion and emission characteristics of gasoline-fueled stratified-charge compression ignition (SCCI) engine according to intake temperaturemore » and compression ratio was examined. We investigated the effects of air-fuel ratio, residual EGR rate and injection timing on the CAI combustion area. In addition, the effect of injection timing on combustion factors such as the start of combustion, its duration and its heat release rate was also investigated. (author)« less
NASA Technical Reports Server (NTRS)
Christoffersen, Roy; Keller, Lindsay P.; Han, Jangmi; Rahman, Zia; Berger, Eve L.
2015-01-01
Focused ion beam (FIB) sectioning has revolutionized preparation of meteorite samples for characterization by analytical transmission electron microscopy (TEM) and other techniques. Although FIB is not "non-destructive" in the purest sense, each extracted section amounts to no more than nanograms (approximately 500 cubic microns) removed intact from locations precisely controlled by SEM imaging and analysis. Physical alteration of surrounding material by ion damage, fracture or sputter contamination effects is localized to within a few micrometers around the lift-out point. This leaves adjacent material intact for coordinate geochemical analysis by SIMS, microdrill extraction/TIMS and other techniques. After lift out, FIB sections can be quantitatively analyzed by electron microprobe prior to final thinning, synchrotron x-ray techniques, and by the full range of state-of-the-art analytical field-emission scanning transmission electron microscope (FE-STEM) techniques once thinning is complete. Multiple meteorite studies supported by FIB/FE-STEM are currently underway at NASA-JSC, including coordinated analysis of refractory phase assemblages in CAIs and fine-grained matrices in carbonaceous chondrites. FIB sectioning of CAIs has uncovered epitaxial and other overgrowth relations between corundum-hibonite-spinel consistent with hibonite preceding corundum and/or spinel in non-equilibrium condensation sequences at combinations of higher gas pressures, dust-gas enrichments or significant nebular transport. For all of these cases, the ability of FIB to allow for coordination with spatially-associated isotopic data by SIMS provides immense value for constraining the formation scenarios of the particular CAI assemblage. For carbonaceous chondrites matrix material, FIB has allowed us to obtain intact continuous sections of the immediate outer surface of Murchison (CM2) after it has been experimentally ion processed to simulate solar wind space weathering. The surface
ERIC Educational Resources Information Center
Brown, John S.; And Others
A question answering system which permits a computer-assisted instruction (CAI) student greater initiative in the variety of questions he can ask is described. A method is presented to represent the dynamic processes of a subject matter area by augmented finite state automata, which permits efficient inferencing about dynamic processes and…
Yin, Yizhi; Donlevy, Sean; Smolikove, Sarit
2016-01-01
Meiosis is a tightly regulated process requiring coordination of diverse events. A conserved ERK/MAPK-signaling cascade plays an essential role in the regulation of meiotic progression. The Thousand And One kinase (TAO) kinase is a MAPK kinase kinase, the meiotic role of which is unknown. We have analyzed the meiotic functions of KIN-18, the homolog of mammalian TAO kinases, in Caenorhabditis elegans. We found that KIN-18 is essential for normal meiotic progression; mutants exhibit accelerated meiotic recombination as detected both by analysis of recombination intermediates and by crossover outcome. In addition, ectopic germ-cell differentiation and enhanced levels of apoptosis were observed in kin-18 mutants. These defects correlate with ectopic activation of MPK-1 that includes premature, missing, and reoccurring MPK-1 activation. Late progression defects in kin-18 mutants are suppressed by inhibiting an upstream activator of MPK-1 signaling, KSR-2. However, the acceleration of recombination events observed in kin-18 mutants is largely MPK-1-independent. Our data suggest that KIN-18 coordinates meiotic progression by modulating the timing of MPK-1 activation and the progression of recombination events. The regulation of the timing of MPK-1 activation ensures the proper timing of apoptosis and is required for the formation of functional oocytes. Meiosis is a conserved process; thus, revealing that KIN-18 is a novel regulator of meiotic progression in C. elegans would help to elucidate TAO kinase’s role in germline development in higher eukaryotes. PMID:26510792
Complete genome sequence of Defluviimonas alba cai42T, a microbial exopolysaccharides producer.
Zhao, Jie-Yu; Geng, Shuang; Xu, Lian; Hu, Bing; Sun, Ji-Quan; Nie, Yong; Tang, Yue-Qin; Wu, Xiao-Lei
2016-12-10
Defluviimonas alba cai42 T , isolated from the oil-production water in Xinjiang Oilfield in China, has a strong ability to produce exopolysaccharides (EPS). We hereby present its complete genome sequence information which consists of a circular chromosome and three plasmids. The strain characteristically contains various genes encoding for enzymes involved in EPS biosynthesis, modification, and export. According to the genomic and physiochemical data, it is predicted that the strain has the potential to be utilized in industrial production of microbial EPS. Copyright © 2016 Elsevier B.V. All rights reserved.
Resonance-enhanced two-photon excitation of CaI
NASA Astrophysics Data System (ADS)
Casero-Junquera, Elena; Lawruszczuk, Rafal; Rostas, Joëlle; Taieb, Guy
1994-07-01
Induced fluorescence following visible (620-655 nm) laser excitation of the CaI radical has been detected not only in the same region (B, A-X transitions), but also in the UV (315-330 nm). The UV two-photon excitation spectrum consists of narrow bands appearing at laser frequencies located within certain bands of the Δ v = 1, 0 sequences of the B 2Σ +-X 2Σ + and A 2Π 1/2-X 2Σ + systems. The main peaks are tentatively assigned to resonance-enhanced excitation of a single vibrational level of the lowest Rydberg D 2Σ + state from successive vibrational levels of the ground state. The excitation process is a one-color two-photon optical—optical-double-resonance via B 2Σ + and A 2Π 1/2 intermediate levels. This analysis is supported by the absorption spectrum observed long ago by Walters and Barratt. The absorption and laser excitation complementary data have been used to derive approximate molecular constants for the D state.
1990-06-01
The objective of this thesis research is to create a tutorial for teaching aspects of undirected graphs in discrete math . It is one of the submodules...of the Discrete Math Tutorial (DMT), which is a Computer Aided Instructional (CAI) tool for teaching discrete math to the Naval Academy and the
1990-06-01
The objective of this thesis research is to create a tutorial for teaching aspects of undirected graphs in discrete math . It is one of the submodules...of the Discrete Math Tutorial (DMT), which is a Computer Aided Instructional (CAI) tool for teaching discrete math to the Naval Academy and the
Fliegner, Maike; Krupp, Kerstin; Brunner, Franziska; Rall, Katharina; Brucker, Sara Y; Briken, Peer; Richter-Appelt, Hertha
2014-03-01
Sexual wellness depends on a person's physical and psychological constitution. Complete Androgen Insensitivity Syndrome (CAIS) and Mayer-Rokitansky-Küster-Hauser Syndrome (MRKHS) can compromise sexual well-being. To compare sexual well-being in CAIS and MRKHS using multiple measures: To assess sexual problems and perceived distress. To gain insight into participants' feelings of inadequacy in social and sexual situations, level of self-esteem and depression. To determine how these psychological factors relate to sexual (dys)function. To uncover what participants see as the source of their sexual problems. Data were collected using a paper-and-pencil questionnaire. Eleven individuals with CAIS and 49 with MRKHS with/without neovagina treatment were included. Rates of sexual dysfunctions, overall sexual function, feelings of inadequacy in social and sexual situations, self-esteem and depression scores were calculated. Categorizations were used to identify critical cases. Correlations between psychological variables and sexual function were computed. Sexually active subjects were compared with sexually not active participants. A qualitative content analysis was carried out to explore causes of sexual problems. An extended list of sexual problems based on the Diagnostic and Statistical Manual of Mental Disorders, 4th ed., text revision, by the American Psychiatric Association and related distress. Female Sexual Function Index (FSFI), German Questionnaire on Feelings of Inadequacy in Social and Sexual Situations (FUSS social scale, FUSS sexual scale), Rosenberg Self-Esteem Scale (RSE), Brief Symptom Inventory (BSI) subscale depression. Open question on alleged causes of sexual problems. The results point to a far-reaching lack of sexual confidence and sexual satisfaction in CAIS. In MRKHS apprehension in sexual situations is a source of distress, but sexual problems seem to be more focused on issues of vaginal functioning. MRKHS women report being satisfied with their
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wei, Tzu-Chieh; C. N. Yang Institute for Theoretical Physics, State University of New York at Stony Brook, Stony Brook, New York 11794-3840; Raussendorf, Robert
2011-10-15
Universal quantum computation can be achieved by simply performing single-qubit measurements on a highly entangled resource state, such as cluster states. Cai, Miyake, Duer, and Briegel recently constructed a ground state of a two-dimensional quantum magnet by combining multiple Affleck-Kennedy-Lieb-Tasaki quasichains of mixed spin-3/2 and spin-1/2 entities and by mapping pairs of neighboring spin-1/2 particles to individual spin-3/2 particles [Phys. Rev. A 82, 052309 (2010)]. They showed that this state enables universal quantum computation by single-spin measurements. Here, we give an alternative understanding of how this state gives rise to universal measurement-based quantum computation: by local operations, each quasichain canmore » be converted to a one-dimensional cluster state and entangling gates between two neighboring logical qubits can be implemented by single-spin measurements. We further argue that a two-dimensional cluster state can be distilled from the Cai-Miyake-Duer-Briegel state.« less
NASA Astrophysics Data System (ADS)
Hashimoto, M.; Takenaka, H.; Higurashi, A.; Nakajima, T.
2017-12-01
Aerosol in the atmosphere is an important constituent for determining the earth's radiation budget, so the accurate aerosol retrievals from satellite is useful. We have developed a satellite remote sensing algorithm to retrieve the aerosol optical properties using multi-wavelength and multi-pixel information of satellite imagers (MWPM). The method simultaneously derives aerosol optical properties, such as aerosol optical thickness (AOT), single scattering albedo (SSA) and aerosol size information, by using spatial difference of wavelegths (multi-wavelength) and surface reflectances (multi-pixel). The method is useful for aerosol retrieval over spatially heterogeneous surface like an urban region. In this algorithm, the inversion method is a combination of an optimal method and smoothing constraint for the state vector. Furthermore, this method has been combined with the direct radiation transfer calculation (RTM) numerically solved by each iteration step of the non-linear inverse problem, without using look up table (LUT) with several constraints. However, it takes too much computation time. To accelerate the calculation time, we replaced the RTM with an accelerated RTM solver learned by neural network-based method, EXAM (Takenaka et al., 2011), using Rster code. And then, the calculation time was shorternd to about one thouthandth. We applyed MWPM combined with EXAM to GOSAT/TANSO-CAI (Cloud and Aerosol Imager). CAI is a supplement sensor of TANSO-FTS, dedicated to measure cloud and aerosol properties. CAI has four bands, 380, 674, 870 and 1600 nm, and observes in 500 meters resolution for band1, band2 and band3, and 1.5 km for band4. Retrieved parameters are aerosol optical properties, such as aerosol optical thickness (AOT) of fine and coarse mode particles at a wavelenth of 500nm, a volume soot fraction in fine mode particles, and ground surface albedo of each observed wavelength by combining a minimum reflectance method and Fukuda et al. (2013). We will show
Yang, Hongyan; Wu, Hao; Gao, Lijuan; Jia, Hongbai; Zhang, Yuan; Cui, Zongjun; Li, Yuhua
2016-12-28
To investigate the effects of Lactobacillus curvatus and Leuconostoc mesenteroides on suan cai (pickled Chinese cabbage) fermentation, L. curvatus and/or Ln. mesenteroides were inoculated into suan cai. Physicochemical indexes were measured, and the microbial dynamics during the fermentation were analyzed by Illumina MiSeq sequencing and quantitative polymerase chain reaction (qPCR). The results showed that inoculation with lactic acid bacteria (LAB) lowered the pH of the fermentation system more rapidly. The decrease in water-soluble carbohydrates in the inoculated treatments occurred more rapidly than in the control. The LAB counts in the control were lower than in other inoculated treatments during the first 12 days of fermentation. According to the Illumina MiSeq sequencing analyses, Firmicutes , Proteobacteria , Bacteroidetes , Actinobacteria , Cyanobacteria , Fusobacteria , and Verrucomicrobia were present in the fermentations, along with other unclassified bacteria. Generally, Firmicutes was predominant during the fermentation in all treatments. At the genus level, 16 genera were detected. The relative abundance of Lactobacillus in all inoculated treatments was higher than in the control. The relative abundance of Lactobacillus in the treatments containing L. curvatus was higher than in the Ln. mesenteroides -only treatment. The relative abundance of Leuconostoc in the Ln. mesenteroides -containing treatments increased continuously throughout the fermentation. Leuconostoc was highest in the Ln. mesenteroides -only treatment. According to the qPCR results, L. curvatus and/or Ln. mesenteroides inoculations could effectively inhabit the fermentation system. L. curvatus dominated the fermentation in the inoculated treatments.
GOSAT CO2 retrieval results using TANSO-CAI aerosol information over East Asia
NASA Astrophysics Data System (ADS)
KIM, M.; Kim, W.; Jung, Y.; Lee, S.; Kim, J.; Lee, H.; Boesch, H.; Goo, T. Y.
2015-12-01
In the satellite remote sensing of CO2, incorrect aerosol information could induce large errors as previous studies suggested. Many factors, such as, aerosol type, wavelength dependency of AOD, aerosol polarization effect and etc. have been main error sources. Due to these aerosol effects, large number of data retrieved are screened out in quality control, or retrieval errors tend to increase if not screened out, especially in East Asia where aerosol concentrations are fairly high. To reduce these aerosol induced errors, a CO2 retrieval algorithm using the simultaneous TANSO-CAI aerosol information is developed. This algorithm adopts AOD and aerosol type information as a priori information from the CAI aerosol retrieval algorithm. The CO2 retrieval algorithm based on optimal estimation method and VLIDORT, a vector discrete ordinate radiative transfer model. The CO2 algorithm, developed with various state vectors to find accurate CO2 concentration, shows reasonable results when compared with other dataset. This study concentrates on the validation of retrieved results with the ground-based TCCON measurements in East Asia and the comparison with the previous retrieval from ACOS, NIES, and UoL. Although, the retrieved CO2 concentration is lower than previous results by ppm's, it shows similar trend and high correlation with previous results. Retrieved data and TCCON measurements data are compared at three stations of Tsukuba, Saga, Anmyeondo in East Asia, with the collocation criteria of ±2°in latitude/longitude and ±1 hours of GOSAT passing time. Compared results also show similar trend with good correlation. Based on the TCCON comparison results, bias correction equation is calculated and applied to the East Asia data.
ERIC Educational Resources Information Center
Tuan, Luu Trong
2015-01-01
Purpose: This paper aims to examine the role of antecedents such as corporate social responsibility (CSR) and entrepreneurial orientation in the chain effect to knowledge sharing among members of Cai Luong theatre companies in the Vietnamese context. Knowledge sharing contributes to the depth of the knowledge pool of both the individuals and the…
Crystal Growth and Scintillation Properties of Eu2+ doped Cs4CaI6 and Cs4SrI6
NASA Astrophysics Data System (ADS)
Stand, L.; Zhuravleva, M.; Chakoumakos, B.; Johnson, J.; Loyd, M.; Wu, Y.; Koschan, M.; Melcher, C. L.
2018-03-01
In this work we present the crystal growth and scintillation properties of two new ternarymetal halide scintillators activated with divalent europium, Cs4CaI6 and Cs4SrI6. Single crystals of each compound were grown in evacuated quartz ampoules via the vertical Bridgman technique using a two-zone transparent furnace. Single crystal X-ray diffraction experiments showed that both crystals have a trigonal (R-3c) structure, with a density of 3.99 g/cm3 and 4.03 g/cm3. The radioluminescence and photoluminescence measurements showed typical luminescence properties due to the 5d-4f radiative transitions in Eu2+. At this early stage of development Cs4SrI6:Eu and Cs4CaI6:Eu have shown very promising scintillation properties, with light yields and energy resolutions of 62,300 ph/MeV and 3.3%, and 51,800 photons/MeV and 3.6% at 662 keV, respectively.
NASA Astrophysics Data System (ADS)
Wei, Tzu-Chieh; Raussendorf, Robert; Kwek, Leong Chuan
2011-10-01
Universal quantum computation can be achieved by simply performing single-qubit measurements on a highly entangled resource state, such as cluster states. Cai, Miyake, Dür, and Briegel recently constructed a ground state of a two-dimensional quantum magnet by combining multiple Affleck-Kennedy-Lieb-Tasaki quasichains of mixed spin-3/2 and spin-1/2 entities and by mapping pairs of neighboring spin-1/2 particles to individual spin-3/2 particles [Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.82.052309 82, 052309 (2010)]. They showed that this state enables universal quantum computation by single-spin measurements. Here, we give an alternative understanding of how this state gives rise to universal measurement-based quantum computation: by local operations, each quasichain can be converted to a one-dimensional cluster state and entangling gates between two neighboring logical qubits can be implemented by single-spin measurements. We further argue that a two-dimensional cluster state can be distilled from the Cai-Miyake-Dür-Briegel state.
Magnetotelluric data, Taos Plateau Volcanic Field, New Mexico
Ailes, Chad E.; Rodriguez, Brian D.
2010-01-01
The population of the San Luis Basin region of northern New Mexico is growing. Water shortfalls could have serious consequences. Future growth and land management in the region depend on accurate assessment and protection of the region's groundwater resources. An important issue in managing the groundwater resources is a better understanding of the hydrogeology of the Santa Fe Group and the nature of the sedimentary deposits that fill the Rio Grande rift, which contain the principal groundwater aquifers. The shallow unconfined aquifer and the deeper confined Santa Fe Group aquifer in the San Luis Basin are the main sources of municipal water for the region. The U.S. Geological Survey (USGS) is conducting a series of multidisciplinary studies of the San Luis Basin. Detailed geologic mapping, high-resolution airborne magnetic surveys, gravity surveys, an electromagnetic survey called magnetotellurics (MT), and hydrologic and lithologic data are being used to better understand the aquifers. This report describes a regional east-west MT sounding profile acquired in late July 2009 across the Taos Plateau Volcanic Field where drillhole data are sparse. Resistivity modeling of the MT data can be used to help map changes in electrical resistivity with depths that are related to differences in rock types. These various rock types help control the properties of aquifers. The purpose of this report is to release the MT sounding data collected along the east-west profile. No interpretation of the data is included.
NASA Astrophysics Data System (ADS)
Tang, Haolan; Liu, Ming-Chang; McKeegan, Kevin D.; Tissot, Francois L. H.; Dauphas, Nicolas
2017-06-01
The isotopic composition of oxygen as well as 26Al-26Mg and 36Cl-36S systematics were studied in Curious Marie, an aqueously altered Allende CAI characterized by a Group II REE pattern and a large 235U excess produced by the decay of short-lived 247Cm. Oxygen isotopic compositions in the secondary minerals of Curious Marie follow a mass-dependent fractionation line with a relatively homogenous depletion in 16O (Δ17O of -8‰) compared to unaltered minerals of CAI components. Both Mg and S show large excesses of radiogenic isotopes (26Mg∗ and 36S∗) that are uniformly distributed within the CAI, independent of parent/daughter ratio. A model initial 26Al/27Al ratio [(6.2 ± 0.9) × 10-5], calculated using the bulk Al/Mg ratio and the uniform δ26Mg∗ ∼ +43‰, is similar to the canonical initial solar system value within error. The exceptionally high bulk Al/Mg ratio of this CAI (∼95) compared to other inclusions is presumably due to Mg mobilization by fluids. Therefore, the model initial 26Al/27Al ratio of this CAI implies not only the early condensation of the CAI precursor but also that aqueous alteration occurred early, when 26Al was still at or near the canonical value. This alteration event is most likely responsible for the U depletion in Curious Marie and occurred at most 50 kyr after CAI formation, leading to a revised estimate of the early solar system 247Cm/235U ratio of (5.6 ± 0.3) × 10-5. The Mg isotopic composition in Curious Marie was subsequently homogenized by closed-system thermal processing without contamination by chondritic Mg. The large, homogeneous 36S excesses (Δ36S∗ ∼ +97‰) detected in the secondary phases of Curious Marie are attributed to 36Cl decay (t1/2 = 0.3 Myr) that was introduced by Cl-rich fluids during the aqueous alteration event that led to sodalite formation. A model 36Cl/35Cl ratio of (2.3 ± 0.6) × 10-5 is calculated at the time of aqueous alteration, translating into an initial 36Cl/35Cl ratio of ∼1.7-3
Problem Solving Process Research of Everyone Involved in Innovation Based on CAI Technology
NASA Astrophysics Data System (ADS)
Chen, Tao; Shao, Yunfei; Tang, Xiaowo
It is very important that non-technical department personnel especially bottom line employee serve as innovators under the requirements of everyone involved in innovation. According the view of this paper, it is feasible and necessary to build everyone involved in innovation problem solving process under Total Innovation Management (TIM) based on the Theory of Inventive Problem Solving (TRIZ). The tools under the CAI technology: How TO mode and science effects database could be very useful for all employee especially non-technical department and bottom line for innovation. The problem solving process put forward in the paper focus on non-technical department personnel especially bottom line employee for innovation.
ERIC Educational Resources Information Center
Brod, Rodney L.
A sociological theory of authority was used to investigate some nonintellective, perhaps unintended, consequences of computer-assisted instruction (CAI) upon student's attitudes and orientations toward the organization of the school. An attitudinal questionnaire was used to survey attitudes toward the teacher and the computer in a junior high…
NASA Astrophysics Data System (ADS)
Kamizuka, Takafumi; Miyata, Takashi; Sako, Shigeyuki; Ohsawa, Ryou; Okada, Kazushi; Uchiyama, Masahito S.; Mori, Kiyoshi; Yamaguchi, Jumpei; Asano, Kentaro; Uchiyama, Mizuho; Sakon, Itsuki; Onaka, Takashi; Kataza, Hirokazu; Hasegawa, Sunao; Usui, Fumihiko; Takato, Naruhisa; Aoki, Tsutomu; Doi, Mamoru; Kato, Natsuko M.; Kitagawa, Yutaro; Kobayakawa, Yutaka; Kohno, Kotaro; Konishi, Masahiro; Minezaki, Takeo; Morokuma, Tomoki; Motohara, Kentaro; Ohashi, Hirofumi; Soyano, Takao; Takahashi, Hidenori; Tamura, Yoichi; Tanabé, Toshihiko; Tanaka, Masuo; Tarusawa, Ken'ichi; Terao, Yasunori; Yoshii, Yuzuru
2016-08-01
MIMIZUKU is the first-generation mid-infrared instrument for the university of Tokyo Atacama Observatory (TAO) 6.5-m telescope. MIMIZUKU provides imaging and spectroscopic monitoring capabilities in a wide wavelength range from 2 to 38 μm, including unique bands like 2.7-μm and 30-μm band. Recently, we decided to add spectroscopic functions, KL-band mode (λ= 2.1-4.0 μm R =λ/Δλ 210) and 2.7-μm band mode ( λ= 2.4-2.95 μm R 620), and continuous spectroscopic coverage from 2.1 to 26 μm is realized by this update. Their optical designing is completed, and fabrications of optical elements are ongoing. As recent progress, we also report the completion of the cryogenic system and optics. The cryogenic system has been updated by changing materials and structures of thermal links, and the temperatures of the optical bench and detector mounting stages finally achieved required temperatures. Their stability against instrument attitude is also confirmed through an inclination test. As for the optics, its gold-plated mirrors have been recovered from galvanic corrosion by refabrication and reconstruction. Enough image quality and stability are confirmed by room-temperature tests. MIMIZUKU is intended to be completed in this autumn, and commissioning at the Subaru telescope and scientific operations on the TAO telescope are planned in 2017 and around 2019, respectively. In this paper, these development activities and future prospects of MIMIZUKU are reported.
McLain, Michael Lee; Sheridan, Timothy J.; Hjalmarson, Harold Paul; ...
2014-11-11
This paper investigates the effects of high dose rate ionizing radiation and total ionizing dose (TID) on tantalum oxide (TaO x) memristors. Transient data were obtained during the pulsed exposures for dose rates ranging from approximately 5.0 ×10 7 rad(Si)/s to 4.7 ×10 8 rad(Si)/s and for pulse widths ranging from 50 ns to 50 μs. The cumulative dose in these tests did not appear to impact the observed dose rate response. Static dose rate upset tests were also performed at a dose rate of ~3.0 ×10 8 rad(Si)/s. This is the first dose rate study on any type ofmore » memristive memory technology. In addition to assessing the tolerance of TaO x memristors to high dose rate ionizing radiation, we also evaluated their susceptibility to TID. The data indicate that it is possible for the devices to switch from a high resistance off-state to a low resistance on-state in both dose rate and TID environments. The observed radiation-induced switching is dependent on the irradiation conditions and bias configuration. Furthermore, the dose rate or ionizing dose level at which a device switches resistance states varies from device to device; the enhanced susceptibility observed in some devices is still under investigation. As a result, numerical simulations are used to qualitatively capture the observed transient radiation response and provide insight into the physics of the induced current/voltages.« less
Tao-Rusyr Caldera, Onekotan Island, Kuril Islands
2017-12-08
More than 9,000 years ago, a catastrophic volcanic eruption created a huge caldera on the southern end of Onekotan Island, one of the Kuril Islands, located off the southern tip of Russia’s Kamchatka Peninsula. Today, the ancient Tao-Rusyr Caldera is filled by the deep blue waters of Kal’tsevoe Lake. The Advanced Land Imager (ALI) on NASA’s Earth Observing-1 (EO-1) satellite acquired this true-color image of southern Onekotan on June 10, 2009. In this late-spring shot, snow or ice lingers on the land, forming white streaks on a brown-and-green land surface. In the northwest quadrant of the caldera is Krenitzyn Peak, which rises to a height of 1,325 meters (4,347 feet). Like the other Kuril Islands, Onekotan lies along the Pacific “Ring of Fire.” The Kuril Island volcanoes are fueled by magma generated by the subduction of the Pacific Plate under the Eurasian Plate, which takes place along a deep trench about 200 kilometers (120 miles) to the islands’ east. The only historical eruption at Krenitzyn Peak occurred in 1952, a week after a magnitude 9.0 earthquake along the subduction fault. NASA Earth Observatory image created by Robert Simmon, using EO-1 ALI data provided courtesy of the NASA EO-1 team. Caption by Michon Scott and Rebecca Lindsey. NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram
Ebiloma, Godwin U; Ayuga, Teresa Díaz; Balogun, Emmanuel O; Gil, Lucía Abad; Donachie, Anne; Kaiser, Marcel; Herraiz, Tomás; Inaoka, Daniel K; Shiba, Tomoo; Harada, Shigeharu; Kita, Kiyoshi; de Koning, Harry P; Dardonville, Christophe
2018-04-25
African trypanosomiasis is a neglected parasitic disease that is still of great public health relevance, and a severe impediment to agriculture in endemic areas. The pathogens possess certain unique metabolic features that can be exploited for the development of new drugs. Notably, they rely on an essential, mitochondrially-localized enzyme, Trypanosome Alternative Oxidase (TAO) for their energy metabolism, which is absent in the mammalian hosts and therefore an attractive target for the design of safe drugs. In this study, we cloned, expressed and purified the physiologically relevant form of TAO, which lacks the N-terminal 25 amino acid mitochondrial targeting sequence (ΔMTS-TAO). A new class of 32 cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde inhibitors was designed and synthesized, enabling the first structure-activity relationship studies on ΔMTS-TAO. Remarkably, we obtained compounds with enzyme inhibition values (IC 50 ) as low as 2 nM, which were efficacious against wild type and multidrug-resistant strains of T. brucei and T. congolense. The inhibitors 13, 15, 16, 19, and 30, designed with a mitochondrion-targeting lipophilic cation tail, displayed trypanocidal potencies comparable to the reference drugs pentamidine and diminazene, and showed no cross-resistance with the critical diamidine and melaminophenyl arsenical classes of trypanocides. The cationic inhibitors 15, 16, 19, 20, and 30 were also much more selective (900 - 344,000) over human cells than the non-targeted neutral derivatives (selectivity >8-fold). A preliminary in vivo study showed that modest doses of 15 and 16 reduced parasitaemia of mice infected with T. b. rhodesiense (STIB900). These compounds represent a promising new class of potent and selective hits against African trypanosomes. Copyright © 2018 Elsevier Masson SAS. All rights reserved.
Secondary processing of chondrules and refractory inclusions (CAIs) by gasdynamic heating
NASA Technical Reports Server (NTRS)
Podolak, M.; Prialnik, D.; Bunch, T. E.; Cassen, P.; Reynolds, R.
1993-01-01
Results of calculations performed to determine the conditions necessary for producing the opaque rims on chondrules and CAI rims by high-speed entry into the transient atmosphere of an accreting meteorite parent body are presented. The sensitivity of these results to variations in critical parameters is investigated. The range of entry velocities which can produce such rims is shown to depend on the size, melting temperature, and thermal conductivity of the particles. For particles greater than 2 mm in radius, with thermal conductivities of 20,000 ergs/sm s K or lower, entry velocities of about 3 km/s suffice. For particle sizes less than 1 mm in radius, the range of encounter velocities that can produce rims is narrow or vanishing, regardless of the thermal conductivity, unless the melting temperature in the outer part of the chondrule has been reduced by compositional heterogeneity.
ERIC Educational Resources Information Center
Davis, Wesley D.
This study evaluated Krell's 1981-82 Scholastic Aptitude Test (SAT) preparatory series software purported to raise students' scores substantially after only a short term of computer-assisted instruction (CAI). Forty-eight college-bound juniors from Escambia County (Florida) were assigned to experimental and control groups. A two-phased pre- and…
MEDLEARN: a computer-assisted instruction (CAI) program for MEDLARS.
Eisenberg, L J; Standing, R A; Tidball, C S; Leiter, J
1978-01-01
*MEDLEARN*, a second-generation computer-assisted instruction (CAI) program available (nationally) since October 1976, provides on-line training for MEDLINE, one of the National Library of Medicine's (NLM) Medical Literature Analysis and Retrieval System (MEDLARS) data base. *MEDLEARN* was developed as a joint effort between NLM and The George Washington University Medical Center. Using MEDLINE formats throughout, *MEDLEARN* combines tutorial dialogue, drill and practice, testing, and simulation. The program was designed in three tracks oriented to basic methods, advanced techniques, and new developments. Each topic is presented on two levels, permitting an alternate explanation for users encountering difficulty. *MEDLEARN*, coded in the computer language PILOT, was developed with a modular structure which promotes ease of writing and revision. A versatile control structure maximizes student control. Frequent interactions check immediate recall, general comprehension, and integration of knowledge. Two MEDLINE simulations are included, providing the student an opportunity to formulate and execute a search, have it evaluated, and then perform the search in MEDLINE. Commenting, news broadcasting, and monitoring (with permission only) capabilities are also available. Subjective field appraisals have been positive and NLM plans to expand *MEDLEARN* and produce similar programs for other data bases. PMID:342015
A New Type of Foreign Clast in A Polymict Ureilite: A CAI or AL-Rich Chondrule
NASA Technical Reports Server (NTRS)
Goodrich, C. A.; Ross, D. K.; Treiman, A. H.
2017-01-01
Introduction: Polymict ureilites are breccias interpreted to represent regolith formed on a ureilitic asteroid [1-3]. They consist of approximately 90-95% clasts of various ureilite types (olivine-pyroxene rocks with Fo 75-95), a few % indigenous feldspathic clasts, and a few % foreign clasts [4-20]. The foreign clasts are diverse, including fragments of H, L, LL and R chondrites, angrites, other achondrites, and dark clasts similar to CC [6,7,9-19]. We report a new type of foreign clast in polymict ureilite DaG 999. Methods: Clast 8 in Dar al Gani (DaG) 999/1 (Museum fur Naturkunde) was discovered during a survey of feldspathic clasts in polymict ureilites [19,20]. It was studied by BEI, EMPA, and X-ray mapping on the JEOL 8530F electron microprobe at ARES, JSC. Petrography and Mineral Compositions: Clast 8 is sub-rounded to irregular in shape, approximately 85 micrometers in diameter, and consists of approximately 68% pyroxene and 32% mesostasis (by area). Part of the pyroxene (top half of clast in Fig. 1a and 2) shows a coarse dendritic morphology; the rest appears massive. Mesostasis may be glassy and contains fine needles/grains of pyroxene. The pyroxene has very high CaO (23.5 wt.%) and Al2O3 (19.7 wt.%), with the formula: (Ca(0.91)Mg(0.63)Fe(0.01)Al(sup VI) (0.38)Cr(0.01)Ti(0.05)1.99 Si2O6. The bulk mesostasis also has very high Al2O3 (approximately 26 wt.%). A bulk composition for the clast was obtained by combining modal abundances with phase compositions (Table 1, Fig. 3). Discussion: The pyroxene in clast 8 has a Ca-Al-(Ti)- rich (fassaitic) composition that is clearly distinct from compositions of pyroxenes in main group ureilites [22] or indigenous feldspathic clasts in polymict ureilites [4-8]. It also has significantly higher Al than fassaite in angrites (up to approximately 12 wt.% [23]), which occur as xenoliths in polymict ureilites. Ca-Al-Ti rich pyroxenes are most commonly found in CAIs, Al-rich chondrules and other types of refractory
Fridrich, Christopher J.; Shroba, Ralph R.; Hudson, Adam M.
2012-01-01
This map covers the Big Costilla Peak, New Mex.&nash;Colo. quadrangle and adjacent parts of three other 7.5 minute quadrangles: Amalia, New Mex.–Colo., Latir Peak, New Mex., and Comanche Point, New Mex. The study area is in the southwesternmost part of that segment of the Sangre de Cristo Mountains known as the Culebra Range; the Taos Range segment lies to the southwest of Costilla Creek and its tributary, Comanche Creek. The map area extends over all but the northernmost part of the Big Costilla horst, a late Cenozoic uplift of Proterozoic (1.7-Ga and less than 1.4-Ga) rocks that is largely surrounded by down-faulted middle to late Cenozoic (about 40 Ma to about 1 Ma) rocks exposed at significantly lower elevations. This horst is bounded on the northwest side by the San Pedro horst and Culebra graben, on the northeast and east sides by the Devils Park graben, and on the southwest side by the (about 30 Ma to about 25 Ma) Latir volcanic field. The area of this volcanic field, at the north end of the Taos Range, has undergone significantly greater extension than the area to the north of Costilla Creek. The horsts and grabens discussed above are all peripheral structures on the eastern flank of the San Luis basin, which is the axial part of the (about 26 Ma to present) Rio Grande rift at the latitude of the map. The Raton Basin lies to the east of the Culebra segment of the Sangre de Cristo Mountains. This foreland basin formed during, and is related to, the original uplift of the Sangre de Cristo Mountains which was driven by tectonic contraction of the Laramide (about 70 Ma to about 40 Ma) orogeny. Renewed uplift and structural modification of these mountains has occurred during formation of the Rio Grande rift. Surficial deposits in the study area include alluvial, mass-movement, and glacial deposits of middle Pleistocene to Holocene age.
Liu, Kai
2013-08-01
The deteriorating situation of migrant workers' health rights protection was once again highlighted in the case of Tseng Hei-tao. This case explicitly and implicitly showed that four conundrums--the Employment Restriction Conundrum, the Occupational Safety and Health (OSH) Legal Conundrum, the Morality Conundrum and the Identity Conundrum--are barriers to migrant workers' right protection. The health rights of migrant workers could be safeguarded by abolishing the outdated household registration system designed in the planned economy era, improving the rule of law, and strengthening administrative supervisions. This would fundamentally remove these barriers and thus contribute to migrant workers' health rights protection.
(K, Na, Li)(Nb, Ta)O3:Mn lead-free single crystal with high piezoelectric properties
Huo, Xiaoqing; Zhang, Rui; Zheng, Limei; Zhang, Shujun; Wang, Rui; Wang, Junjun; Sang, Shijing; Yang, Bin; Cao, Wenwu
2016-01-01
Lead-free single crystal, (K, Na, Li)(Nb, Ta)O3:Mn, was successfully grown using top-seeded solution growth method. Complete matrix of dielectric, piezoelectric and elastic constants for [001]C poled single crystal was determined. The piezoelectric coefficient d33 measured by the resonance method was 545 pC/N, which is almost three times that of its ceramic counterpart. The values measured by the Berlincourt meter ( d33∗=630pC/N) and strain-field curve ( d33∗∗=870pm/V) were even higher. The differences were assumed to relate with the different extrinsic contributions of domain wall vibration and domain wall translation during the measurements by different approaches, where the intrinsic contribution (on the order of 539 pm/V) was supposed to be the same. The crystal has ultrahigh electromechanical coupling factor (k33 ~ 95%) and high ultrasound velocity, which make it promising for high frequency medical transducer applications. PMID:27594704
ERIC Educational Resources Information Center
Daellenbach, Lawrence A.; And Others
The purpose of this study was to determine the effect of computer assisted instruction (CAI) on the cognitive and affective development of college students enrolled in a principles of macroeconomics course. The hypotheses of the experiment were stated as follows: In relation to the traditional principles course, the experimental treatment will…
NASA Astrophysics Data System (ADS)
Thompson, R. A.; Turner, K. J.; Cosca, M. A.; Drenth, B.; Grauch, V. J. S.
2016-12-01
The Pliocene Taos Plateau Volcanic Field (TPVF) is the largest volcanic field of the Rio Grande rift. Deposits of the TPVF are distributed across 4500 km2 in the southern part of the 11,500 km2 San Luis Valley in southern Colorado and northern New Mexico constituting a major component of the structural San Luis Basin (SLB) fill. Exposed deposit thicknesses range from a few meters near the distal termini of basaltic lava flows to 240 m in the Rio Grande gorge near Taos, NM. New geologic mapping and 100 high-resolution 40Ar/39Ar age determinations help identify a complex distribution of >50 exposed eruptive centers ranging in composition from basalt to rhyolite. Total eruptive volume, estimated from geologic map relations, geophysical modeling of basin geometry and subsurface distribution of basaltic deposits, are approximately 300 km3; comprising 66% Servilleta Basalt (tholeiite), 3% mildly alkaline trachybasalt & trachyandesite, 12% olivine andesite, 17% dacite, and <1% rhyolite. Servilleta Basalt is preserved throughout the TPVF, ranging in age from 5.3 Ma to 2.95 Ma; maximum thickness is exposed in the Rio Grande gorge in association with the largest Pliocene sub-basin in the valley, the Taos graben. Smaller volume basalt centers as young as 2.9 Ma are spatially associated with monogenetic trachybasalt and trachyandesite centers ( 4.3 Ma to 2.8 Ma) along the uplifted footwall of a western fault-bounded sub-basin, the Las Mesitas graben. The plateau surface underlain primarily by Servilleta Basalt is punctuated by large ( 15 km3 erupted volume typical) monogenetic andesitic shield volcanoes ( 5-4.4 Ma); north-south aligned and distributed along the central axis of the SLB, parallel to major intrabasin faults. Large (up to 21 km3 erupted volume) zoned dacitic lava dome complexes ( 5 Ma Guadalupe Mountain/Cerro Negro, 3.9 Ma Ute Mountain, and 3 Ma San Antonio Mountain) reach elevations of 3300 m, 770 m above the valley floor each spatially and temporally associated
Saving Energy around the House = Tien Tan Trong Viec Tieu Thu Nang Luc Trong Nha.
ERIC Educational Resources Information Center
Noyes, Marilyn; Jarrett, Von
This bilingual booklet is intended to help Vietnamese refugees learn basic energy conservation skills. Included in the booklet are Vietnamese and English translations of basic energy conservation practices related to the following areas: heating, cooling, cooking, using refrigerators and freezers, lighting, water heating, doing laundry, pursuing…
NASA Astrophysics Data System (ADS)
Han, Jangmi; Brearley, Adrian J.
2016-06-01
We have carried out a FIB/TEM study of refractory CAI-like objects in one AOA from the ALHA77307 CO3.0 chondrite. The CAI-like objects in the AOA consist of a zoned sequence with a spinel-rich core through an intergrowth layer of spinel and Al-Ti-rich diopside to a diopside rim. The spinel-rich core consists of polycrystalline aggregates of spinel and ±minor melilite showing equilibrated grain boundary textures. The intergrowth layer contains fine-grained diopside and spinel with minor anorthite with highly curved and embayed grain boundaries. The diopside rim consists of polycrystalline aggregates of diopside. The compositions of pyroxene change significantly outward from Al-Ti-rich diopside in contact with the spinel-rich core to Al-Ti-poor diopside next to the surrounding olivine of the AOA. Overall microstructural and chemical characteristics suggest that the spinel-rich core formed under equilibrium conditions whereas the intergrowth layer is the result of reactions that occurred under conditions that departed significantly from equilibrium. The remarkable changes in formation conditions of the CAI-like objects may have been achieved by transport and injection of refractory objects into a region of a partially-condensed, Ca,Ti-saturated gas which reacted with spinel and melilite to form Al-Ti-rich diopside. Crystallographically-oriented TiO2 nanoparticles decorate the grain boundaries between spinel grains and between spinel and Al-Ti-rich diopside grains. During the disequilibrium back-reaction of spinel with a partially-condensed, Ca,Ti-saturated gas, metastable TiO2 nanoparticles may have condensed by an epitaxial nucleation mechanism and grown on the surface of spinel. These TiO2 nanoparticles are disordered intergrowths of the two TiO2 polymorphs, anatase and rutile. These nanoparticles are inferred to have nucleated as anatase that underwent partial transformation into rutile. The local presence of the TiO2 nanoparticles and intergrowth of anatase and
Organic pollution and salt intrusion in Cai Nuoc District, Ca Mau Province, Vietnam.
Tho, Nguyen; Vromant, Nico; Hung, Nguyen Thanh; Hens, Luc
2006-07-01
In Ca Mau, Vietnam, farmers converted from rice to shrimp farming, while ignoring the degradation of the aquatic environment. We assessed the seasonal variations in organic pollution of the surface water and salt intrusion in one district and assessed the difference in chemical characteristics of the surface water of shrimp ponds and canals. Several variables reflecting salinity and organic pollution were measured in the wet and dry season. The results show that in the dry season salinity increased to 37.36-42.73 g l(-1) and COD and suspended solids increased to a maximum of 268.7 mg l(-1) and 1312.0 mg l(-1), respectively. In the wet season salinity values of 8.16 to 10.60 g l(-1) were recorded, indicating that salinity could no longer be washed out completely in this season. It is concluded that salinity and suspended solids in the aquatic environment in the Cai Nuoc district are increased by shrimp monoculture, whereas organic pollution is contributed by human population pressure.
Okita, P.M.; Shanks, Wayne C.
1992-01-01
Carbonate and sulfide minerals from the Molango, Mexico, and TaoJiang, China, Mn deposits display similar and distinctive ??34S and ??13C patterns in intervals of manganese carbonate mineralization. ??13C-values for Mn-bearing carbonate range from -17.8 to +0.5??? (PDB), with the most negative values occurring in high-grade ore zones that are composed predominantly of rhodochrosite. In contrast, calcite from below, within and above Mn-carbonate zones at Molango has ??13C???0??? (PDB). Markedly negative ??13C data indicate that a large proportion of the carbon in Mn-carbonates was derived from organic matter oxidation. Diagenetic reactions using MnO2 and SO2-4 to oxidize sedimentary organic matter were the principle causes of such 12C enrichment. Pyrite content and sulfide ?? 34S-values also show distinctive variations. In unmineralized rocks, very negative ??34S-values (avg. < -21??? CDT) and abundant pyrite content suggest that pyrite formed from diagenetic, bacteriogenic sulfate reduction. In contrast, Mn-bearing horizons typically contain only trace amounts of pyrite (e.g., <0.5 wt% S with ??34S-values 34S-enriched, in some cases to nearly the value for contemporaneous seawater. 34S-enriched pyrite from the Mn-carbonate intervals indicates sulfide precipitation in an environment that underwent extensive SO2-4 reduction, and was largely a closed system with regard to exchange of sulfate and dissolved sulfide with normal seawater. The occasional occurrence of 34S-depleted pyrite within Mn-carbonate zones dominated by 34S-enriched pyrite is evidence that closed-system conditions were intermittent and limited to local pore waters and did not involve entire sedimentary basins. Mn-carbonate precipitation may have occluded porosity in the surficial sediments, thus establishing an effective barrier to SO2-4 exchange with overlying seawater. Similar isotopic and mineralogic characteristics from both the Molango and TaoJiang deposits, widely separated in geologic time and
LG based decision aid for naval tactical action officer's (TAO) workstation
NASA Astrophysics Data System (ADS)
Stilman, Boris; Yakhnis, Vladimir; Umanskiy, Oleg; Boyd, Ron
2005-05-01
In the increasingly NetCentric battlespace of the 21st century, Stilman Advanced Strategies Linguistic Geometry software has the potential to revolutionize the way that the Navy fights in two key areas: as a Tactical Decision Aid and for creating a relevant Common Operating Picture. Incorporating STILMAN's software into a prototype Tactical Action Officers (TAO) workstation as a Tactical Decision Aid (TDA) will allow warfighters to manage their assets more intelligently and effectively. This prototype workstation will be developed using human-centered design principles and will be an open, component-based architecture for combat control systems for future small surface combatants. It will integrate both uninhabited vehicles and onboard sensors and weapon systems across a squadron of small surface combatants. In addition, the hypergame representation of complex operations provides a paradigm for the presentation of a common operating picture to operators and personnel throughout the command hierarchy. In the hypergame technology there are game levels that span the range from the tactical to the global strategy level, with each level informing the others. This same principle will be applied to presenting the relevant common operating picture to operators. Each operator will receive a common operating picture that is appropriate for their level in the command hierarchy. The area covered by this operating picture and the level of detail contained within it will be dependent upon the specific tasks the operator is performing (supervisory vice tactical control) and the level of the operator (or command personnel) within the command hierarchy. Each level will inform the others to keep the picture concurrent and up-to-date.
Huang, Xin; Gollin, Susanne M.; Raja, Siva; Godfrey, Tony E.
2002-01-01
Amplification of chromosomal band 11q13 is a common event in human cancer. It has been reported in about 45% of head and neck carcinomas and in other cancers including esophageal, breast, liver, lung, and bladder cancer. To understand the mechanism of 11q13 amplification and to identify the potential oncogene(s) driving it, we have fine-mapped the structure of the amplicon in oral squamous cell carcinoma cell lines and localized the proximal and distal breakpoints. A 5-Mb physical map of the region has been prepared from which sequence is available. We quantified copy number of sequence-tagged site markers at 42–550 kb intervals along the length of the amplicon and defined the amplicon core and breakpoints by using TaqMan-based quantitative microsatellite analysis. The core of the amplicon maps to a 1.5-Mb region. The proximal breakpoint localizes to two intervals between sequence-tagged site markers, 550 kb and 160 kb in size, and the distal breakpoint maps to a 250 kb interval. The cyclin D1 gene maps to the amplicon core, as do two new expressed sequence tag clusters. We have analyzed one of these expressed sequence tag clusters and now report that it contains a previously uncharacterized gene, TAOS1 (tumor amplified and overexpressed sequence 1), which is both amplified and overexpressed in oral cancer cells. The data suggest that TAOS1 may be an amplification-dependent candidate oncogene with a role in the development and/or progression of human tumors, including oral squamous cell carcinomas. The approach described here should be useful for characterizing amplified genomic regions in a wide variety of tumors. PMID:12172009
ERIC Educational Resources Information Center
Chamberlain, Ed
A cost benefit study was conducted to determine the effectiveness of a computer assisted instruction/computer management system (CAI/CMS) as an alternative to conventional methods of teaching reading within Chapter 1 and DPPF funded programs of the Columbus (Ohio) Public Schools. The Chapter 1 funded Compensatory Language Experiences and Reading…
Yasawong, Montri; Areekit, Supatra; Pakpitchareon, Arda; Santiwatanakul, Somchai; Chansiri, Kosum
2011-01-01
The bacterial strain TD1 was isolated from Tao Dam hot spring in Thailand. Strain TD1 was Gram positive, rod-shaped, aerobic, motile, and endospore forming. The cell was 2.0–40 μm in length and about 0.4 μm in diameter. The optimum growth occurred at 55–60 °C and at pH 7–8. Strain TD1 was able to grow on medium containing up to 10% NaCl. The DNA G+C content was 38.9 mol%. The cellular fatty acid content was mainly C16:0, which comprised 25.04% of the total amount of cellular fatty acid. 16S rDNA showed 99% identity to Aeribacillus pallidus DSM 3670T. Bayesian tree analysis strongly supported the idea that strain TD1 is affiliated with genus Aeribacillus, as Aeribacillus pallidus strain TD1. Although the 16S rDNA of A. pallidus strain TD1 is similar to that of A. pallidus DSM 3670T, some physiological properties and the cellular fatty acid profiles differ significantly. A. pallidus strain TD1 can produce extracellular pectate lyase, which has not been reported elsewhere for other bacterial strains in the genus Aeribacillus. A. pallidus strain TD1 may be a good candidate as a pectate lyase producer, which may have useful industrial applications. PMID:21954359
Seenithurai, Sonai; Chai, Jeng-Da
2016-01-01
Due to the presence of strong static correlation effects and noncovalent interactions, accurate prediction of the electronic and hydrogen storage properties of Li-adsorbed acenes with n linearly fused benzene rings (n = 3–8) has been very challenging for conventional electronic structure methods. To meet the challenge, we study these properties using our recently developed thermally-assisted-occupation density functional theory (TAO-DFT) with dispersion corrections. In contrast to pure acenes, the binding energies of H2 molecules on Li-adsorbed acenes are in the ideal binding energy range (about 20 to 40 kJ/mol per H2). Besides, the H2 gravimetric storage capacities of Li-adsorbed acenes are in the range of 9.9 to 10.7 wt%, satisfying the United States Department of Energy (USDOE) ultimate target of 7.5 wt%. On the basis of our results, Li-adsorbed acenes can be high-capacity hydrogen storage materials for reversible hydrogen uptake and release at ambient conditions. PMID:27609626
Yeh, Chia-Nan; Chai, Jeng-Da
2016-01-01
We investigate the role of Kekulé and non-Kekulé structures in the radical character of alternant polycyclic aromatic hydrocarbons (PAHs) using thermally-assisted-occupation density functional theory (TAO-DFT), an efficient electronic structure method for the study of large ground-state systems with strong static correlation effects. Our results reveal that the studies of Kekulé and non-Kekulé structures qualitatively describe the radical character of alternant PAHs, which could be useful when electronic structure calculations are infeasible due to the expensive computational cost. In addition, our results support previous findings on the increase in radical character with increasing system size. For alternant PAHs with the same number of aromatic rings, the geometrical arrangements of aromatic rings are responsible for their radical character. PMID:27457289
STRUCTURE AND EVOLUTION OF COMPETITION-ORGANIZED ECOLOGICAL COMMUNITIES
It is frequently asserted that conservation biology can advance only by transcending the current species-by-species approach, and refocusing on whole-ecosystem preservation. trong scientific basis does not presently exist for carrying out ecosystem viability analysis, and in part...
ECOLOGICAL RISK ASSESSMENT: PROTECTING NORTHWEST ANADROMOUS SALMONID STOCKS
Ecological risk assessment is usually defined as the process that evaluates the likelihood that adverse ecological effects are occurring, or may occur, as a result of exposure to one or mare stressors. he basic concept, while straightforward, is difficult to apply. trong reaction...
New Petrology, Mineral Chemistry and Stable MG Isotope Compositions of an Allende CAI: EK-459-7-2
NASA Technical Reports Server (NTRS)
Jeffcoat, C. R.; Kerekgyarto, A. G.; Lapen, T. J.; Righter, M.; Simon, J. I.; Ross, D. K.
2016-01-01
Calcium-aluminum-rich inclusions (CAIs) are the key to understanding physical and chemical conditions in the nascent solar nebula. These inclusions have the oldest radiometric ages of solar system materials and are composed of phases that are predicted to condense early from a gas of solar composition. Thus, their chemistry and textures record conditions and processes in the earliest stages of development of the solar nebula. Type B inclusions are typically larger and more coarse grained than other types with substantial evidence that many of them were at least partially molten. Type B inclusions are further subdivided into Type B1 (possess thick melilite mantle) and Type B2 (lack melilite mantle). Despite being extensively studied, the origin of the melilite mantles of Type B1 inclusions remains uncertain. We present petrologic and chemical data for a Type B inclusion, EK-459-7-2, that bears features found in both Type B1 and B2 inclusions and likely represents an intermediate between the two types. Detailed studies of more of these intermediate objects may help to constrain models for Type B1 rim formation.
NASA Technical Reports Server (NTRS)
Sasaki, S.; Nagahara, H.; Kitagami, K.; Nakagawa, Y.
1994-01-01
In some Ca-Al-rich inclusion (CAI) grains, mass-dependent isotopic fractionations of Mg, Si, and O are observed and large Mg isotopic fractionation is interpreted to have been produced by cosmochemical processes such as evaporation and condensation. Mass-dependent Mg isotopic fractionation was found in olivine chondrules of Allende meteorites. Presented is an approximate formula for the temperature of the solar nebula that depends on heliocentric distance and the initial gas distribution. Shock heating during solar nebula formation can cause evaporative fractionation within interstellar grains involved in a gas at the inner zone (a less than 3 AU) of the disk. Alternatively collision of late-accreting gas blobs might cause similar heating if Sigma(sub s) and Sigma are large enough. Since the grain size is small, the solid/gas mass ratio is low and solar (low P(sub O2)), and the ambient gas pressure is low, this heating event could not produce chondrules themselves. Chondrule formation should proceed around the disk midplane after dust grains would grow and sediment to increase the solid/gas ratio there. The heating source there is uncertain, but transient rapid accretion through the disk could release a large amount of heat, which would be observed as FU Orionis events.
2006-04-21
regions of the killifish brain ere selected based on consistent c-Fos expression observed n pilot experiments: the anterior telencephalon (area ventralis...elencephali pars ventralis (Vv) and dorsalis (Vd)), the poste- ior telencephalon (diencephalic ventricle (DiV) and anterior arvocellular preoptic...neurons. trong, punctuate nuclear staining was visualized in neurons of he telencephalon (area ventralis telencephali), mesencephalon optic tectum
Yang, Liulin; Li, Yun; Wei, Zhi; Chang, Xiao
2018-06-01
Neuroblastoma is a highly complex and heterogeneous cancer in children. Acquired genomic alterations including MYCN amplification, 1p deletion and 11q deletion are important risk factors and biomarkers in neuroblastoma. Here, we performed a co-expression-based gene network analysis to study the intrinsic association between specific genomic changes and transcriptome organization. We identified multiple gene coexpression modules which are recurrent in two independent datasets and associated with functional pathways including nervous system development, cell cycle, immune system process and extracellular matrix/space. Our results also indicated that modules involved in nervous system development and cell cycle are highly associated with MYCN amplification and 1p deletion, while modules responding to immune system process are associated with MYCN amplification only. In summary, this integrated analysis provides novel insights into molecular heterogeneity and pathogenesis of neuroblastoma. This article is part of a Special Issue entitled: Accelerating Precision Medicine through Genetic and Genomic Big Data Analysis edited by Yudong Cai & Tao Huang. Copyright © 2017. Published by Elsevier B.V.
Li, Liang; Han, Qiutong; Tang, Lanqin; Zhang, Yuan; Li, Ping; Zhou, Yong; Zou, Zhigang
2018-01-25
Herein, orthorhombic regular Bi 4 TaO 8 Cl square nanoplates with an edge length of about 500 nm and a thickness of about 100 nm were successfully synthesized using a facile molten salt route. The as-prepared square nanoplates have been proven to be of {001} crystal facets as two dominantly exposed surfaces. The density functional theory calculation and photo-deposition of noble metal experiment demonstrate the electron and hole separation on different crystal facets and reveal that {001} crystal facets are in favor of the reduction reaction. Since the square nanoplate structure exhibits dominant exposure surfaces of the {001} facets, the molten salt route-based samples basically possess an obviously higher photocatalytic activity than those prepared by the solid state reaction (SSR) method. This study may provide inspiration for fabricating efficient photocatalysts.
Mohandas, Janet C; Abou-Hamad, Edy; Callens, Emmanuel; Samantaray, Manoja K; Gajan, David; Gurinov, Andrei; Ma, Tao; Ould-Chikh, Samy; Hoffman, Adam S; Gates, Bruce C; Basset, Jean-Marie
2017-08-01
Air-stable catalysts consisting of tantalum nitride nanoparticles represented as a mixture of Ta x N y and TaO x N y with diameters in the range of 0.5 to 3 nm supported on highly dehydroxylated silica were synthesized from TaMe 5 (Me = methyl) and dimeric Ta 2 (OMe) 10 with guidance by the principles of surface organometallic chemistry (SOMC). Characterization of the supported precursors and the supported nanoparticles formed from them was carried out by IR, NMR, UV-Vis, extended X-ray absorption fine structure, and X-ray photoelectron spectroscopies complemented with XRD and high-resolution TEM, with dynamic nuclear polarization surface enhanced NMR spectroscopy being especially helpful by providing enhanced intensities of the signals of 1 H, 13 C, 29 Si, and 15 N at their natural abundances. The characterization data provide details of the synthesis chemistry, including evidence of (a) O 2 insertion into Ta-CH 3 species on the support and (b) a binuclear to mononuclear transformation of species formed from Ta 2 (OMe) 10 on the support. A catalytic test reaction, cyclooctene epoxidation, was used to probe the supported nanoparticles, with 30% H 2 O 2 serving as the oxidant. The catalysts gave selectivities up to 98% for the epoxide at conversions as high as 99% with a 3.4 wt% loading of Ta present as Ta x N y /TaO x N y .
Luo, W; Chen, M; Chen, A; Dong, W; Hou, X; Pu, B
2015-04-01
To isolate lactic acid bacteria (LAB) from pao cai, a Chinese traditional fermented vegetable, with outstanding inhibitory activity against Salmonella inoculated on fresh-cut apple, using a modelling method. Four kinds of pao cai were selected. A total of 122 isolates exhibited typical LAB characteristics: Gram-positive and catalase negative, among which 104 (85·24%) colonies showed antibacterial activity against Salmonella by the well diffusion assay. Four colonies showing maximum antibacterial radius against Salmonella were selected to co-inoculate with Salmonella on fresh-cut apple and stored at 10°C, further identified as three strains of Lactobacillus plantarum and one strain of Lactobacillus brevis by 16s rRNA gene sequence analysis. The modified Gompertz model was employed to analyse the growth of the micro-organisms on apple wedges. Two of the four selected strains showed antagonistic activity against Salmonella on fresh-cut apple, one of which, RD1, exhibited best inhibitory activity (Salmonella were greatly inhibited when co-inoculated with RD1 at 10°C at 168 h). No deterioration in odour or appearance of the apple piece was observed by the triangle test when fresh-cut apple was inoculated with RD1. The mathematical modelling method is essential to select LAB with outstanding inhibitory activity against Salmonella associated with fresh-cut apple. LAB RD1 holds promise for the preservation of fresh-cut apple. This study provided a new method on fresh-cut product preservation. Besides, to make the LAB isolating procedure a more correct one, this study first added the mathematical modelling method to the isolating procedure. © 2014 The Society for Applied Microbiology.
Shared Versus Distributed Memory Multiprocessors
1991-01-01
multiprocessors should hawe shared or dis.trimuted meieo-% ha~ trr ~ g ’’~ de~i c4~accio;, S Cm teaicners argue S trongly tor Outiding (li15 tri huted...Applications, MIT Press (1985). 161 D. Gajski et el., "Cedar," Proc. Compcon, pp. 306-309 (Spring 19S9). 171 S. Ahuja, N. Carriero and D. Gelernter, "Linda
1980-09-01
de.tona1Uted1 over a mass;ive Kayenta sandstone formation. Thes- e.ventsl- provi ic data for checking, the calculations for motion in :1 s;trong1...53 ~ l Z Kayenta ;andst-ne depOsit similar to thit, of CUNSf 1. The thickness of the soil was v,ried from 0 to 6 ft. Measurements of vertical and
Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy
Shen, Jie; Li, Zhangfang; Li, Wenting; Ge, Ying; Xie, Min; Lv, Meng; Fan, Yanfei; Chen, Zhi; Zhao, Defu; Han, Yajuan
2015-01-01
To determine serum cytokine profiles in Graves' disease (GD) patients with or without active and inactive thyroid associated ophthalmopathy (TAO), we recruited 65 subjects: 10 GD only (without TAO), 25 GD + active TAO, 20 GD + TAO, and 10 healthy controls. Liquid chip assay was used to measure serum Th1/Th2/Th17 cytokines including IFN-γ (interferon-gamma), TNF-α (tumor necrosis factor-alpha), IL-1α (interleukin-1 alpha), IL-1Ra (IL-1 receptor antagonist), IL-2, IL-4, IL-6, and IL-17 and two chemokines: RANTES (regulated upon activation, normal T cell expressed and secreted) and IP-10 (IFN-γ-induced protein 10). Serum levels of TSH (thyroid stimulating hormone) receptor autoantibodies (TRAb) were measured using an enzyme linked immunosorbent assay. Compared with healthy controls, TAO patients showed significantly elevated serum levels of IFN-γ, TNF-α, IL-1α, IL-4, IL-6, IL-17, and IP-10. Comparing active and inactive TAO, serum Th1 cytokines IFN-γ and TNF-α were elevated in active TAO, while serum Th2 cytokine IL-4 was elevated in inactive TAO. Serum Th17 cytokine IL-17 was elevated in GD but reduced in both active and inactive TAO. A positive correlation was found between TRAb and IFN-γ, TNF-α, IL-1α, IL-2, IL-4, and IL-6. Taken together, serum Th1/Th2/Th17 cytokines and chemokines reflect TAO disease activity and may be implicated in TAO pathogenesis. PMID:26089587
Fridrich, Christopher J.; Shroba, Ralph R.; Pillmore, Charles L.; Hudson, Adam M.
2009-01-01
This geologic map covers four 7.5-minute quadrangles-The Wall, NM-CO (New Mexico-Colorado), Vermejo Park, NM-CO, Ash Mountain, NM, and Van Bremmer Park, NM. The study area straddles the boundary between the eastern flank of the Sangre de Cristo Mountains and the western margin of the Raton Basin, with about two-thirds of the map area in the basin. The Raton Basin is a foreland basin that formed immediately eastward of the Sangre de Cristo Mountains during their initial uplift, in the Late Cretaceous through early Eocene Laramide orogeny. Subsequently, these mountains have been extensively modified during formation of the Rio Grande rift, from late Oligocene to present. The map area is within that part of the Sangre de Cristo Mountains that is called the Culebra Range. Additionally, the map covers small parts of the Devil's Park graben and the Valle Vidal half-graben, in the northwestern and southwestern parts of the map area, respectively. These two grabens are small intermontaine basins, that are satellitic to the main local basin of the Rio Grande rift, the San Luis Basin, that are an outlying, early- formed part of the rift, and that separate the Culebra Range from the Taos Range, to the southwest.
NASA Technical Reports Server (NTRS)
Keppenne, Christian L.; Rienecker, Michele; Borovikov, Anna Y.; Suarez, Max
1999-01-01
A massively parallel ensemble Kalman filter (EnKF)is used to assimilate temperature data from the TOGA/TAO array and altimetry from TOPEX/POSEIDON into a Pacific basin version of the NASA Seasonal to Interannual Prediction Project (NSIPP)ls quasi-isopycnal ocean general circulation model. The EnKF is an approximate Kalman filter in which the error-covariance propagation step is modeled by the integration of multiple instances of a numerical model. An estimate of the true error covariances is then inferred from the distribution of the ensemble of model state vectors. This inplementation of the filter takes advantage of the inherent parallelism in the EnKF algorithm by running all the model instances concurrently. The Kalman filter update step also occurs in parallel by having each processor process the observations that occur in the region of physical space for which it is responsible. The massively parallel data assimilation system is validated by withholding some of the data and then quantifying the extent to which the withheld information can be inferred from the assimilation of the remaining data. The distributions of the forecast and analysis error covariances predicted by the ENKF are also examined.
NASA Technical Reports Server (NTRS)
Keppenne, C. L.; Rienecker, M.; Borovikov, A. Y.
1999-01-01
Two massively parallel data assimilation systems in which the model forecast-error covariances are estimated from the distribution of an ensemble of model integrations are applied to the assimilation of 97-98 TOPEX/POSEIDON altimetry and TOGA/TAO temperature data into a Pacific basin version the NASA Seasonal to Interannual Prediction Project (NSIPP)ls quasi-isopycnal ocean general circulation model. in the first system, ensemble of model runs forced by an ensemble of atmospheric model simulations is used to calculate asymptotic error statistics. The data assimilation then occurs in the reduced phase space spanned by the corresponding leading empirical orthogonal functions. The second system is an ensemble Kalman filter in which new error statistics are computed during each assimilation cycle from the time-dependent ensemble distribution. The data assimilation experiments are conducted on NSIPP's 512-processor CRAY T3E. The two data assimilation systems are validated by withholding part of the data and quantifying the extent to which the withheld information can be inferred from the assimilation of the remaining data. The pros and cons of each system are discussed.
Zhao, Jun; Zhang, Baohong; Zhu, Jianwei; Nussinov, Ruth; Ma, Buyong
2018-06-01
Amyloid formation and deposition of immunoglobulin light-chain proteins in systemic amyloidosis (AL) cause major organ failures. While the κ light-chain is dominant (λ/κ=1:2) in healthy individuals, λ is highly overrepresented (λ/κ=3:1) in AL patients. The structural basis of the amyloid formation and the sequence preference are unknown. We examined the correlation between sequence and structural stability of dimeric variable domains of immunoglobulin light chains using molecular dynamics simulations of 24 representative dimer interfaces, followed by energy evaluation of conformational ensembles for 20 AL patients' light chain sequences. We identified a stable interface with displaced N-terminal residues, provides the structural basis for AL protein fibrils formation. Proline isomerization may cause the N-terminus to adopt amyloid-prone conformations. We found that λ light-chains prefer misfolded dimer conformation, while κ chain structures are stabilized by a natively folded dimer. Our study may facilitate structure-based small molecule and antibody design to inhibit AL. This article is part of a Special Issue entitled: Accelerating Precision Medicine through Genetic and Genomic Big Data Analysis edited by Yudong Cai & Tao Huang. Copyright © 2017 Elsevier B.V. All rights reserved.
17. Photocopy of architectural drawing (from Albuquerque Area Indian Health ...
17. Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers, Murray, and Phillip, Architects, New York, NY, 1934 Elevations - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM
An acid-tolerant ammonia-oxidizing γ-proteobacterium from soil
Hayatsu, Masahito; Tago, Kanako; Uchiyama, Ikuo; Toyoda, Atsushi; Wang, Yong; Shimomura, Yumi; Okubo, Takashi; Kurisu, Futoshi; Hirono, Yuhei; Nonaka, Kunihiko; Akiyama, Hiroko; Itoh, Takehiko; Takami, Hideto
2017-01-01
Nitrification, the microbial oxidation of ammonia to nitrate via nitrite, occurs in a wide range of acidic soils. However, the ammonia-oxidizing bacteria (AOB) that have been isolated from soil to date are acid-sensitive. Here we report the isolation and characterization of an acid-adapted AOB from an acidic agricultural soil. The isolated AOB, strain TAO100, is classified within the Gammaproteobacteria based on phylogenetic characteristics. TAO100 can grow in the pH range of 5–7.5 and survive in highly acidic conditions until pH 2 by forming cell aggregates. Whereas all known gammaproteobacterial AOB (γ-AOB) species, which have been isolated from marine and saline aquatic environments, are halophiles, TAO100 is not phenotypically halophilic. Thus, TAO100 represents the first soil-originated and non-halophilic γ-AOB. The TAO100 genome is considerably smaller than those of other γ-AOB and lacks several genes associated with salt tolerance which are unnecessary for survival in soil. The ammonia monooxygenase subunit A gene of TAO100 and its transcript are higher in abundance than those of ammonia-oxidizing archaea and betaproteobacterial AOB in the strongly acidic soil. These results indicate that TAO100 plays an important role in the nitrification of acidic soils. Based on these results, we propose TAO100 as a novel species of a new genus, Candidatus Nitrosoglobus terrae. PMID:28072419
An acid-tolerant ammonia-oxidizing γ-proteobacterium from soil.
Hayatsu, Masahito; Tago, Kanako; Uchiyama, Ikuo; Toyoda, Atsushi; Wang, Yong; Shimomura, Yumi; Okubo, Takashi; Kurisu, Futoshi; Hirono, Yuhei; Nonaka, Kunihiko; Akiyama, Hiroko; Itoh, Takehiko; Takami, Hideto
2017-05-01
Nitrification, the microbial oxidation of ammonia to nitrate via nitrite, occurs in a wide range of acidic soils. However, the ammonia-oxidizing bacteria (AOB) that have been isolated from soil to date are acid-sensitive. Here we report the isolation and characterization of an acid-adapted AOB from an acidic agricultural soil. The isolated AOB, strain TAO100, is classified within the Gammaproteobacteria based on phylogenetic characteristics. TAO100 can grow in the pH range of 5-7.5 and survive in highly acidic conditions until pH 2 by forming cell aggregates. Whereas all known gammaproteobacterial AOB (γ-AOB) species, which have been isolated from marine and saline aquatic environments, are halophiles, TAO100 is not phenotypically halophilic. Thus, TAO100 represents the first soil-originated and non-halophilic γ-AOB. The TAO100 genome is considerably smaller than those of other γ-AOB and lacks several genes associated with salt tolerance which are unnecessary for survival in soil. The ammonia monooxygenase subunit A gene of TAO100 and its transcript are higher in abundance than those of ammonia-oxidizing archaea and betaproteobacterial AOB in the strongly acidic soil. These results indicate that TAO100 plays an important role in the nitrification of acidic soils. Based on these results, we propose TAO100 as a novel species of a new genus, Candidatus Nitrosoglobus terrae.
15. Photocopy of architectural drawing (from Albuquerque Area Indian Health ...
15. Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers, Murray, and Phillip, Architects, New York, NY, 1934 First Floor - plumbing - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM
18. Photocopy of architectural drawing (from Albuquerque Area Indian Health ...
18. Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers, Murray, and Phillip, Architects, New York, NY, 1934 Detail sheet - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM
14. Photocopy of architectural drawing (from Albuquerque Area Indian Health ...
14. Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers, Murray, and Phillip, Architects, New York, N&, 1934 Foundation Plan - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM
16 Photocopy of architectural drawing (from Albuquerque Area Indian Health ...
16 Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers Murray, and Phillip, Architects, New York, NY, 1934 first floor mechanical plan - heating - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM
Tao, Wensi; Ayala-Haedo, Juan A; Field, Matthew G; Pelaez, Daniel; Wester, Sara T
2017-12-01
The purpose of this study was to characterize the intrinsic cellular properties of orbital adipose-derived stem cells (OASC) from patients with thyroid-associated orbitopathy (TAO) and healthy controls. Orbital adipose tissue was collected from a total of nine patients: four controls and five patients with TAO. Isolated OASC were characterized with mesenchymal stem cell-specific markers. Orbital adipose-derived stem cells were differentiated into three lineages: chondrocytes, osteocytes, and adipocytes. Reverse transcription PCR of genes involved in the adipogenesis, chondrogenesis, and osteogenesis pathways were selected to assay the differentiation capacities. RNA sequencing analysis (RNA-seq) was performed and results were compared to assess for differences in gene expression between TAO and controls. Selected top-ranked results were confirmed by RT-PCR. Orbital adipose-derived stem cells isolated from orbital fat expressed high levels of mesenchymal stem cell markers, but low levels of the pluripotent stem cell markers. Orbital adipose-derived stem cells isolated from TAO patients exhibited an increase in adipogenesis, and a decrease in chondrogenesis and osteogenesis. RNA-seq disclosed 54 differentially expressed genes. In TAO OASC, expression of early neural crest progenitor marker (WNT signaling, ZIC genes and MSX2) was lost. Meanwhile, ectopic expression of HOXB2 and HOXB3 was found in the OASC from TAO. Our results suggest that there are intrinsic genetic and cellular differences in the OASC populations derived from TAO patients. The upregulation in adipogenesis in OASC of TAO may be is consistent with the clinical phenotype. Downregulation of early neural crest markers and ectopic expression of HOXB2 and HOXB3 in TAO OASC demonstrate dysregulation of developmental and tissue patterning pathways.
Tao, Wensi; Ayala-Haedo, Juan A.; Field, Matthew G.; Pelaez, Daniel; Wester, Sara T.
2017-01-01
Purpose The purpose of this study was to characterize the intrinsic cellular properties of orbital adipose-derived stem cells (OASC) from patients with thyroid-associated orbitopathy (TAO) and healthy controls. Methods Orbital adipose tissue was collected from a total of nine patients: four controls and five patients with TAO. Isolated OASC were characterized with mesenchymal stem cell–specific markers. Orbital adipose-derived stem cells were differentiated into three lineages: chondrocytes, osteocytes, and adipocytes. Reverse transcription PCR of genes involved in the adipogenesis, chondrogenesis, and osteogenesis pathways were selected to assay the differentiation capacities. RNA sequencing analysis (RNA-seq) was performed and results were compared to assess for differences in gene expression between TAO and controls. Selected top-ranked results were confirmed by RT-PCR. Results Orbital adipose-derived stem cells isolated from orbital fat expressed high levels of mesenchymal stem cell markers, but low levels of the pluripotent stem cell markers. Orbital adipose-derived stem cells isolated from TAO patients exhibited an increase in adipogenesis, and a decrease in chondrogenesis and osteogenesis. RNA-seq disclosed 54 differentially expressed genes. In TAO OASC, expression of early neural crest progenitor marker (WNT signaling, ZIC genes and MSX2) was lost. Meanwhile, ectopic expression of HOXB2 and HOXB3 was found in the OASC from TAO. Conclusion Our results suggest that there are intrinsic genetic and cellular differences in the OASC populations derived from TAO patients. The upregulation in adipogenesis in OASC of TAO may be is consistent with the clinical phenotype. Downregulation of early neural crest markers and ectopic expression of HOXB2 and HOXB3 in TAO OASC demonstrate dysregulation of developmental and tissue patterning pathways. PMID:29214313
Who Goes There? Linking Remote Cameras and Schoolyard Science to Empower Action
ERIC Educational Resources Information Center
Tanner, Dawn; Ernst, Julie
2013-01-01
Taking Action Opportunities (TAO) is a curriculum that combines guided reflection, a focus on the local environment, and innovative use of wildlife technology to empower student action toward improving the environment. TAO is experientially based and uses remote cameras as a tool for schoolyard exploration. Through TAO, students engage in research…
Wu, Chih-Jen; Chen, Jui-Tai; Yen, Ting-Lin; Jayakumar, Thanasekaran; Chou, Duen-Suey; Hsiao, George; Sheu, Joen-Rong
2011-01-01
Tao-Hong-Si-Wu-Tang (THSWT) is a famous traditional Chinese medicine (TMC). In the present study, oral administration of THSWT (0.7 and 1.4 g kg−1day−1) for 14 days before MCAO dose-dependently attenuated focal cerebral ischemia in rats. MCAO-induced focal cerebral ischemia was associated with increases in hypoxia-inducible factor (HIF)-1α, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, and active caspase-3 expressions in ischemic regions. These expressions were obviously inhibited by 0.7 g kg−1day−1 THSWT treatment. In addition, THSWT inhibited platelet aggregation stimulated by collagen in washed platelets. In an in vivo study, THSWT (16 g kg−1) significantly prolonged platelet plug formation in mice. However, THSWT (20 and 40 μg mL−1) did not significantly reduce the electron spin resonance (ESR) signal intensity of hydroxyl radical (OH•) formation. In conclusion, the most important findings of this study demonstrate for the first time that THSWT possesses potent neuroprotective activity against MCAO-induced focal cerebral ischemia in vivo. This effect may be mediated, at least in part, by the inhibition of both HIF-1α and TNF-α activation, followed by the inhibition of inflammatory responses (i.e., iNOS expression), apoptosis formation (active caspase-3), and platelet activation, resulting in a reduction in the infarct volume in ischemia-reperfusion brain injury. PMID:21076527
Electronic structure and charge transport in nonstoichiometric tantalum oxide
NASA Astrophysics Data System (ADS)
Perevalov, T. V.; Gritsenko, V. A.; Gismatulin, A. A.; Voronkovskii, V. A.; Gerasimova, A. K.; Aliev, V. Sh; Prosvirin, I. A.
2018-06-01
The atomic and electronic structure of nonstoichiometric oxygen-deficient tantalum oxide TaO x<2.5 grown by ion beam sputtering deposition was studied. The TaO x film content was analyzed by x-ray photoelectron spectroscopy and by quantum-chemistry simulation. TaO x is composed of Ta2O5, metallic tantalum clusters and tantalum suboxides. A method for evaluating the stoichiometry parameter of TaO x from the comparison of experimental and theoretical photoelectron valence band spectra is proposed. The charge transport properties of TaO x were experimentally studied and the transport mechanism was quantitatively analyzed with four theoretical dielectric conductivity models. It was found that the charge transport in almost stoichiometric and nonstoichiometric tantalum oxide can be consistently described by the phonon-assisted tunneling between traps.
HỖ TRỢ CỦA GIA ĐÌNH ĐỐI VỚI NAM TIÊM CHÍCH MA TÚY NHIỄM HIV TẠI HÀ NỘI
Ngọc, Lùng Bích; Ly, An Thanh; Hòa, Trần Thị; Giang, Lê Minh
2016-01-01
Nghiên cứu định tính nhằm mô tả hỗ trợ của gia đình trong chăm sóc sức khỏe, đặc biệt trong điều trị HIV và nghiện chắt của nam tiêm chích ma túy nhiễm HIV tại Hà Nội. Kết quả phân tích cho thấy gia đình chủ yếu hỗ trợ tài chính, tinh thần và chăm sóc sức khỏe trong khi các hỗ trợ thông tin liên quan đến điều trị HIV và nghiện chất cho nam tiêm chích ma túy nhiễm HIV của gia đình còn khá hạn chế. Hỗ trợ của gia đình cho nam tiêm chích ma túy nhiễm HIV khác nhau giữa các giai đoạn sử dụng ma túy, nhiễm HIV, điều trị HIV và điều trị nghiện chất. Đáng chú ý là việc tiết lộ tình trạng nhiễm HIV đã giúp các nam tiêm chích ma túy nhận được nhiều hơn sự hỗ trợ từ gia đình. Các can thiệp nhằm nâng cao hiệu quả điều trị HIV và điều trị nghiện chất cho nam tiêm chích ma túy nhiễm HIV cần tính đến sự tham gia hỗ trợ của gia đình. PMID:28393100
Chai, Jeng-Da
2017-01-28
We propose hybrid schemes incorporating exact exchange into thermally assisted-occupation-density functional theory (TAO-DFT) [J.-D. Chai, J. Chem. Phys. 136, 154104 (2012)] for an improved description of nonlocal exchange effects. With a few simple modifications, global and range-separated hybrid functionals in Kohn-Sham density functional theory (KS-DFT) can be combined seamlessly with TAO-DFT. In comparison with global hybrid functionals in KS-DFT, the resulting global hybrid functionals in TAO-DFT yield promising performance for systems with strong static correlation effects (e.g., the dissociation of H 2 and N 2 , twisted ethylene, and electronic properties of linear acenes), while maintaining similar performance for systems without strong static correlation effects. Besides, a reasonably accurate description of noncovalent interactions can be efficiently achieved through the inclusion of dispersion corrections in hybrid TAO-DFT. Relative to semilocal density functionals in TAO-DFT, global hybrid functionals in TAO-DFT are generally superior in performance for a wide range of applications, such as thermochemistry, kinetics, reaction energies, and optimized geometries.
JPRS Report, Science & Technology USSR: Physics & Mathematics
1991-03-07
field B < mw 2 / e (mw - mass of gauge W- boson ) does not invalidate this approximation inasmuch as the respective momentum integrals remain...model (sin29w = Vi where 0W - angle of W- boson momentum) indicate that, in an ultras- trong magnetic field, photon fusion produces more elec- tron... boson field throughout the 8^8* range. This study was made within the scope of Project N 344 in the Government Program "High-Temperature
The Vietnam Petroleum Industry: Positioned for Growth but Ripe for Regional Complications
2013-10-30
monopolistic character of PVN means the Vietnamese government is a major part of all aspects of the industry. Secondly, faced with increasing demand for...2013, JSTOR. 17 “U.S. EIA, “Vietnam” 20 18 Trong Vu and Simon Hall, “Oil Market Changes as Vietnam Build Another Refinery,” The Wall...Vietnam to Push Ahead with Offshore Exploration.” 23 Ibid. 24 Ibid. 25 Vu and Hall, “Oil Market Changes as Vietnam Build Another Refinery
Vietnamese Hurricane Response Fact Sheets
Các tờ dữ kiện được cung cấp nơi đây mô tả vai trò của EPA trong việc đáp ứng với bão và cách các chương trình cụ thể cung cấp sự hỗ trợ. The Vietnamese fact sheets provided here describe EPA's role in a hurricane response.
Taoism and Its Implications for Science Education.
ERIC Educational Resources Information Center
Hua, Hsiao-Peng; Chang, Chun-Yen; MacRaven, Maggie Maeve
As one of the major schools of thought in ancient China, Taoism centers on the concept of "Tao", the Way, which has two distinct characteristics: (1) Tao itself can be deemed as a final "reality" that is equivalent to the ontology of the Universe; and (2) Tao itself cannot be defined directly by human language. Taoism posits a holistically…
NIR camera and spectrograph SWIMS for TAO 6.5m telescope: array control system and its performance
NASA Astrophysics Data System (ADS)
Terao, Yasunori; Motohara, Kentaro; Konishi, Masahiro; Takahashi, Hidenori; Kato, Natsuko M.; Kitagawa, Yutaro; Kobayakawa, Yutaka; Ohashi, Hirofumi; Tateuchi, Ken; Todo, Soya
2016-08-01
SWIMS (Simultaneous-color Wide-field Infrared Multi-object Spectrograph) is a near-infrared imager and multi-object spectrograph as one of the first generation instruments for the University of Tokyo Atacama Observatory (TAO) 6.5m telescope. In this paper, we describe an array control system of SWIMS and results of detector noise performance evaluation. SWIMS incorporates four (and eight in future) HAWAII-2RG focal plane arrays for detectors, each driven by readout electronics components: a SIDECAR ASIC and a JADE2 Card. The readout components are controlled by a HAWAII-2RG Testing Software running on a virtual Windows machine on a Linux PC called array control PC. All of those array control PCs are then supervised by a SWIMS control PC. We have developed an "array control software system", which runs on the array control PC to control the HAWAII-2RG Testing Software, and consists of a socket client and a dedicated server called device manager. The client runs on the SWIMS control PC, and the device manager runs on the array control PC. An exposure command, issued by the client on the SWIMS control PC, is sent to the multiple device managers on the array control PCs, and then multiple HAWAII-2RGs are driven simultaneously. Using this system, we evaluate readout noise performances of the detectors, both in a test dewar and in a SWIMS main dewar. In the test dewar, we confirm the readout noise to be 4.3 e- r.m.s. by 32 times multiple sampling when we operate only a single HAWAII-2RG, whereas in the case of simultaneous driving of two HAWAII-2RGs, we still obtain sufficiently low readout noise of 10 e- r.m.s. In the SWIMS main dewar, although there are some differences between the detectors, the readout noise is measured to be 4:1-4:6 e- r.m.s. with simultaneous driving by 64 times multiple sampling, which meets the requirement for background-limited observations in J band of 14 e- r.m.s..
A method for evaluating competency in assessment and management of suicide risk.
Hung, Erick K; Binder, Renée L; Fordwood, Samantha R; Hall, Stephen E; Cramer, Robert J; McNiel, Dale E
2012-01-01
Although health professionals increasingly are expected to be able to assess and manage patients' risk for suicide, few methods are available to evaluate this competency. This report describes development of a competency-assessment instrument for suicide risk-assessment (CAI-S), and evaluates its use in an objective structured clinical examination (OSCE). The authors developed the CAI-S on the basis of the literature on suicide risk-assessment and management, and consultation with faculty focus groups from three sites in a large academic psychiatry department. The CAI-S structures faculty ratings regarding interviewing and data collection, case formulation and presentation, treatment-planning, and documentation. To evaluate the CAI-S, 31 faculty members used it to rate the performance of 31 learners (26 psychiatric residents and 5 clinical psychology interns) who participated in an OSCE. After interviewing a standardized patient, learners presented their risk-assessment findings and treatment plans. Faculty used the CAI-S to structure feedback to the learners. In a subsidiary study of interrater reliability, six faculty members rated video-recorded suicide risk-assessments. The CAI-S showed good internal consistency, reliability, and interrater reliability. Concurrent validity was supported by the finding that CAI-S ratings were higher for senior learners than junior learners, and were higher for learners with more clinical experience with suicidal patients than learners with less clinical experience. Faculty and learners rated the method as helpful for structuring feedback and supervision. The findings support the usefulness of the CAI-S for evaluating competency in suicide risk-assessment and management.
Grauch, V.J.S.; Drenth, Benjamin J.; Thompson, Ren A.; Bauer, Paul W.
2015-08-01
This report presents geophysical interpretations of regional subsurface geology in the vicinity of the Tailing Facility of the Questa Mine near Guadalupe Mountain, Taos County, New Mexico, in cooperation with the New Mexico Environment Department. The interpretations were developed from aeromagnetic data, regional gravity data, data from four ground magnetic traverses, geologic mapping, a digital elevation model, and information from a few shallow wells. The resolution of the geophysical data is only appropriate for a broad assessment of the regional setting. Aeromagnetic data provided the most comprehensive information for interpretation. Qualitative and semiquantitative interpretations indicate the nature and extent of volcanic rocks, their relative depths, and inferred contacts between them, as well as conjectured locations of faults. In particular, the aeromagnetic data indicate places where volcanic rocks extend at shallow depths under sedimentary cover. Trachydacites of Guadalupe Mountain are magnetic, but their associated aeromagnetic anomalies are opposite in sign over the northern versus the southern parts of the mountain. The difference indicates that lavas erupted during different magnetic-polarity events in the north (reverse polarity) versus the south (normal polarity) and therefore have different ages. We postulate a buried volcano with reverse-polarity magnetization lies under the northeast side of Guadalupe Mountain, which likely predated the exposed trachydacites. Faults interpreted for the study area generally align with known fault zones. We interpret a northern extension to one of these faults that crosses northwesterly underneath the Tailing Facility. Gravity data indicate that Guadalupe Mountain straddles the western margin of a subbasin of the Rio Grande rift and that significant (>400 meters) thicknesses of both volcanic and sedimentary rocks underlie the mountain.
How to Treat a Patient with Thromboangiitis Obliterans: A Systematic Review.
Fazeli, Bahare; Dadgar Moghadam, Maliheh; Niroumand, Shabnam
2018-05-01
To date, there is still no treatment protocol for patients with thromboangiitis obliterans (TAO) who are also afflicted with critical limb ischemia (CLI). Smoking cessation on its own cannot be considered a treatment for the purposes of salvaging a limb of a TAO patient with CLI. The aim of this review was to evaluate different studies of various treatment protocols for avoiding amputation in TAO patients. A systematic search for relevant studies dating from 1990 to the end of 2016 was performed on the PubMed, SCOPUS, and Science Direct databases. Only 24 studies fulfilled the inclusion criteria, of which only one was a randomized controlled trial (RCT). The remaining studies were quasi-experimental with various treatments and follow-up durations. Therefore, meta-analysis was not performed. Judging from the major amputation rates after the suggested treatments were performed, no treatment was particularly effective. This review demonstrated that more standard RCTs are needed to resolve this treatment issue involved in TAO. In addition, because health insurance coverage for TAO patients differs by country, regional cost-benefit and cost-efficacy studies of the suggested treatments for TAO are highly recommended. Copyright © 2018 Elsevier Inc. All rights reserved.
Thermal Acoustic Oscillation: Causes, Detection, Analysis, and Prevention
NASA Technical Reports Server (NTRS)
Christie, R. J.; Hartwig, J. W.
2014-01-01
Thermal Acoustic Oscillations (TAO) can occur in cryogenic systems and produce significant sources of heat. This source of heat can increase the boil off rate of cryogenic propellants in spacecraft storage tanks and reduce mission life. This paper discusses the causes of TAO, how it can be detected, what analyses can be done to predict it, and how to prevent it from occurring.The paper provides practical insight into what can aggravate instability, practical methods for mitigation, and when TAO does not occur. A real life example of a cryogenic system with an unexpected heat source is discussed, along with how TAO was confirmed and eliminated.
Politics, culture, and the legitimacy of disease: the case of Buerger's disease.
Lockwood, Stephen J; Bresler, Scott C; Granter, Scott R
2016-09-01
Thromboangiitis obliterans (TAO) or Buerger's disease is a rare form of vasculitis with distinctive clinical and pathological features that carries significant morbidity, often leading to amputation, and is strongly associated with tobacco smoking. Despite its distinctive clinicopathological characteristics, the existence of TAO as an entity sui generis was challenged for many years as it languished in relative obscurity. Then, as societal attitudes towards smoking changed, TAO not only became accepted as a disease entity, it quite literally became a poster child to illustrate the ills of smoking. Herein, we examine the history of TAO to illustrate the power of societal attitudes and politics in shaping medicine.
2005-01-01
small to moderate amounts of wispy ( Delphinapterus leucas ) from the St. Lawrence estuary.7 eosinophilic cytoplasm. Nuclei were round to oval with...Press, Ox- ford, 1986 3 De Guise S, Lagac6 A, B6land P: Tumors in St. Lawr- ence beluga whales ( Delphinapterus leucas ). Vet Pathol 31:444-449, 1994 4...Lagac6 A, B6land P, Higgins R, Arms- trong D, Shugart LR: Pathology of stranded beluga J- whales ( Delphinapterus leucas ) from the St. Lawrence Fig. 5
A network-based method for the identification of putative genes related to infertility.
Wang, ShaoPeng; Huang, GuoHua; Hu, Qinghua; Zou, Quan
2016-11-01
Infertility has become one of the major health problems worldwide, with its incidence having risen markedly in recent decades. There is an urgent need to investigate the pathological mechanisms behind infertility and to design effective treatments. However, this is made difficult by the fact that various biological factors have been identified to be related to infertility, including genetic factors. A network-based method was established to identify new genes potentially related to infertility. A network constructed using human protein-protein interactions based on previously validated infertility-related genes enabled the identification of some novel candidate genes. These genes were then filtered by a permutation test and their functional and structural associations with infertility-related genes. Our method identified 23 novel genes, which have strong functional and structural associations with previously validated infertility-related genes. Substantial evidence indicates that the identified genes are strongly related to dysfunction of the four main biological processes of fertility: reproductive development and physiology, gametogenesis, meiosis and recombination, and hormone regulation. The newly discovered genes may provide new directions for investigating infertility. This article is part of a Special Issue entitled "System Genetics" Guest Editor: Dr. Yudong Cai and Dr. Tao Huang. Copyright © 2016 Elsevier B.V. All rights reserved.
Computer-Assisted Instruction Guide.
ERIC Educational Resources Information Center
Entelek, Inc., Newburyport, MA.
Provided is a compilation of abstracts of currently available computer-assisted instructional (CAI) programs. The guide contains the specifications of all operational CAI programs that have come under the surveillance of ENTELEK's CAI Information Exchange since its establishment in 1965. A total of 226 CAI programs by 160 authors at 38 CAI centers…
Mohaseb, Kam; Linder, Mark; Rootman, Jack; Wilkins, G E; Schechter, Martin T; Dolman, Peter J; Singer, Joel
2008-01-01
To construct a patient-based symptom questionnaire to facilitate early referral of thyroid-associated orbitopathy (TAO) in Graves' hyperthyroidism (GH). Phase I of our study involved developing a symptomatology-based questionnaire for the self-reporting of TAO symptoms in patients recently diagnosed with GH. Phase II involved administering the questionnaire along with a standard ophthalmic examination to a screening cohort of patients newly diagnosed with GH. Symptoms highly associated with the clinical diagnosis of TAO were used to construct a tool with the highest possible sensitivity. Phase III involved validation of this tool in a new cohort of patients recently diagnosed with GH. For each patient, the diagnosis of TAO was made by both a standardized orbital ophthalmic exam and the questionnaire. Results from the questionnaire were then compared to the clinical examination. The questionnaire was compared to the standardized examination and found to have a sensitivity of 0.76 and a specificity of 0.82 in the validation phase of the study. This questionnaire may be a useful tool in clinical practice to allow identification of patients with TAO secondary to GH. Future studies using this questionnaire are needed to determine whether earlier identification and management of these patients is associated with reduced morbidity from TAO.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Chang, Y. -S.; Kotamarthi, R.; Hartmann, H. M.
The San Luis Valley (SLV)–Taos Plateau study area in south-central Colorado and north-central New Mexico is a large alpine valley surrounded by mountains with an area of approximately 6,263,000 acres (25,345 km 2) (Figure ES.1-1). This area receives ample sunshine throughout the year, making it an ideal location for solar energy generation, and there are currently five photovoltaic facilities operating on private lands in the SLV, ranging in capacity from 1 to 30 megawatt (MW). In 2012 the Bureau of Land Management (BLM) launched its Solar Energy Program, which included the identification of four solar energy zones (SEZs) in themore » SLV totaling 16,308 acres (66 km 2), as well as over 50,000 (202 km 2) acres of other BLM-administered lands potentially available for application for solar development. The SEZ areas, named Antonito Southeast, De Tilla Gulch, Fourmile East, and Los Mogotes East, were defined by the BLM as areas well-suited for utility-scale (i.e., larger than 20 MW) production of solar energy where solar energy development would be prioritized (BLM 2012). Nonetheless, it was recognized that solar development in the SEZs would result in some unavoidable adverse impacts, and so the BLM initiated a solar regional mitigation strategy (SRMS) study for three of the SEZs (BLM and Argonne 2016). The SRMS is designed to identify residual impacts of solar development in the SEZs (that is, those that cannot be avoided or minimized onsite), identify those residual impacts that warrant compensatory mitigation when considering the regional status and trends of the resources, identify appropriate regional compensatory mitigation locations and actions to address those residual impacts, and recommend appropriate fees to implement those compensatory mitigation measures.« less
Hwang, Gyo-Seung; Hayashi, Hideki; Tang, Liang; Ogawa, Masahiro; Hernandez, Heidy; Tan, Alex Y; Li, Hongmei; Karagueuzian, Hrayr S; Weiss, James N; Lin, Shien-Fong; Chen, Peng-Sheng
2006-12-12
The role of intracellular calcium (Ca(i)) in defibrillation and vulnerability is unclear. We simultaneously mapped epicardial membrane potential and Ca(i) during shock on T-wave episodes (n=104) and attempted defibrillation episodes (n=173) in 17 Langendorff-perfused rabbit ventricles. Unsuccessful and type B successful defibrillation shocks were followed by heterogeneous distribution of Ca(i), including regions of low Ca(i) surrounded by elevated Ca(i) ("Ca(i) sinkholes") 31+/-12 ms after shock. The first postshock activation then originated from the Ca(i) sinkhole 53+/-14 ms after the shock. No sinkholes were present in type A successful defibrillation. A Ca(i) sinkhole also was present 39+/-32 ms after a shock on T that induced ventricular fibrillation, followed 22+/-15 ms later by propagated wave fronts that arose from the same site. This wave propagated to form a spiral wave and initiated ventricular fibrillation. Thapsigargin and ryanodine significantly decreased the upper limit of vulnerability and defibrillation threshold. We studied an additional 7 rabbits after left ventricular endocardial cryoablation, resulting in a thin layer of surviving epicardium. Ca(i) sinkholes occurred 31+/-12 ms after the shock, followed in 19+/-7 ms by first postshock activation in 63 episodes of unsuccessful defibrillation. At the Ca(i) sinkhole, the rise of Ca(i) preceded the rise of epicardial membrane potential in 5 episodes. There is a heterogeneous postshock distribution of Ca(i). The first postshock activation always occurs from a Ca(i) sinkhole. The Ca(i) prefluorescence at the first postshock early site suggests that reverse excitation-contraction coupling might be responsible for the initiation of postshock activations that lead to ventricular fibrillation.
Transaortic TAVI Is a Valid Alternative to Transapical Approach.
O' Sullivan, Katie E; Hurley, Eoghan T; Segurado, Ricardo; Sugrue, Declan; Hurley, John P
2015-05-01
Transcatheter aortic valve implantation (TAVI) can be performed via a number of different anatomical approaches based on patient characteristics and operator choice. The aim of this study was to compare procedural outcomes between transaortic (TAo) and transapical (TA) approaches in an effort to establish whether any differences exist. A systematic review and meta-analysis of the current literature reporting outcomes for patients undergoing TAo and TA TAVI was performed to compare outcomes using each vascular approach to valve deployment. A total of 10 studies and 1736 patients were included. A total of 193 patients underwent TAo and 1543 TA TAVI. No significant difference in 30-day mortality was identified (TAo 9.4, TA 10.4 p = 0.7). There were no significant differences identified between TAo and TA TAVI in procedural success rate (96.3% vs. 93.7% p = 0.3), stroke and transient ischemic attack (TIA) incidence (1.8% vs. 2.3% p = 0.7), major bleed (5.8% vs. 5.5% p = 0.97) or pacemaker insertion rates (6.1% vs. 7.4% p = 0.56). In addition, the incidence of clinically significant paravalvular regurgitation (PVR) was the same between groups (6.7% vs. 11% p = 0.43). Comparison of TAo and TA approaches revealed equivalent outcomes in 30-day mortality, procedural success, major bleeding, stroke/TIA incidence, pacemaker insertion rates and paravalvular leak. Heart teams should be familiar with the use of both TA and TAo access and tailor their selection on a case-to-case basis. © 2015 Wiley Periodicals, Inc.
Cytoplasmic pH influences cytoplasmic calcium in MC3T3-E1 osteoblast cells
NASA Technical Reports Server (NTRS)
Lin, H. S.; Hughes-Fulford, M.; Kumegawa, M.; Pitts, A. C.; Snowdowne, K. W.
1993-01-01
We found that the cytoplasmic concentration of calcium (Cai) of MC3T3-E1 osteoblasts was influenced by the type of pH buffer we used in the perfusing medium, suggesting that intracellular pH (pHi) might influence Cai. To study this effect, the Cai and pHi were monitored as we applied various experimental conditions known to change pHi. Exposure to NH4Cl caused a transient increase in both pHi and Cai without a change in extracellular pH (pHo). Decreasing pHo and pHi by lowering the bicarbonate concentration of the medium decreased Cai, and increasing pHi by the removal of 5% CO2 increased Cai. Clamping pHi to known values with 10 microM nigericin, a potassium proton ionophore, also influenced Cai: acid pHi lowered Cai, whereas alkaline pHi increased it. The rise in Cai appears to be very sensitive to the extracellular concentration of calcium, suggesting the existence of a pH-sensitive calcium influx mechanism. We conclude that physiologic changes in pH could modulate Cai by controlling the influx of calcium ions and could change the time course of the Cai transient associated with hormonal activation.
Burge, D M; Sugarman, I S
2002-12-01
To review the current approach of paediatric surgeons to the exclusion of androgen insensitivity syndrome (CAIS) in girls with inguinal hernias (IH), a questionnaire was sent to all specialist paediatric surgeons in the United Kingdom and Ireland asking if they exclude CAIS, how they exclude it, and what they say to parents preoperatively. In all, 32 surgeons responded (29%); 41% made no attempt to exclude CAIS because they thought the incidence was too low to justify exclusion; 19(59%) excluded CAIS at the time of surgery by assessment of the internal genitalia. Only 1 performed karyotyping primarily, and then only for bilateral IH. Although most would proceed to karyotyping if the primary assessment suggested CAIS, some would not. Of those who exclude CAIS, only 1 mentions CAIS preoperatively, 6 others mention gonadal inspection, and 12/19 (63%) make no comment. Thirty-one surgeons agreed to take part in a prospective study to define the incidence of CAIS in girls with IH. It is concluded that surgeons who exclude CAIS in girls with IH adopt different assessment methods, some of which may be unreliable. However, many do not attempt to exclude CAIS, believing the incidence to be too low. As the health and medicolegal consequences of failing to exclude CAIS may be considerable, surgeons should consider changing their practice. A prospective study should be undertaken to determine the incidence of CAIS in girls with IH.
Variation of oxygen content in selected potassium fluorido-oxido-tantalate phases
NASA Astrophysics Data System (ADS)
Boča, Miroslav; Moncoĺ, Ján; Netriová, Zuzana; Velič, Dušan; Jerigová, Monika; Nunney, Tim S.; Baily, Christopher J.; Kubíková, Blanka; Šimko, František; Janderka, Pavel
2011-12-01
The compound K 3[TaO 4]•K 3[TaF 4O 2] crystallises in a tetragonal system (space group I-4) with cell parameters a = 6.2220(3) Å and c = 8.7625(34) Å, respectively. The crystal structure consists of two anions, [TaO 4] 3- and [TaF 4O 2] 3- and cations K +. The tantalum atoms lie in special positions and serve as centres of both anions, which are substitution disorders. XPS measurements confirmed the existence of different binding energies corresponding to the different bonds of Ta sbnd O and Ta sbnd F. Oxygen is bound more strongly in [TaF 4O 2] 3-. By combination of single crystal analysis, XRD, SIMS and XPS it was suggested that previously reported cubic phase K 3TaOF 6 is in fact K 3TaO 2F 4 and previously reported tetragonal phase K 3TaO 2F 4 is in fact K 3[TaO 4]•K 3[TaF 4O 2].
Hwang, Gyo-Seung; Tang, Liang; Joung, Boyoung; Morita, Norishige; Hayashi, Hideki; Karagueuzian, Hrayr S.; Weiss, James N.; Lin, Shien-Fong; Chen, Peng-Sheng
2008-01-01
Objectives To test the hypothesis that superiority of biphasic waveform (BW) over monophasic waveform (MW) defibrillation shocks is attributable to less intracellular calcium (Cai) transient heterogeneity. Background The mechanism by which BW shocks have a higher defibrillation efficacy than MW shocks remains unclear. Methods We simultaneously mapped epicardial membrane potential (Vm) and Cai during 6 ms MW and 3/3 ms BW shocks in 19 Langendorff-perfused rabbit ventricles. After shock, the percentage of depolarized area was plotted over time. The maximum (peak) postshock values (VmP and CaiP, respectively) were used to measure heterogeneity. Higher VmP and CaiP imply less heterogeneity. Results The defibrillation threshold was for BW and MW shocks were 288±99 V and 399±155 V, respectively (p=0.0005). Successful BW shocks had higher VmP (88±9 %) and CaiP (70±13 %) than unsuccessful MW shocks (VmP 76 %±10, p<0.001; CaiP, 57±8 %, p<0.001) of the same shock strength. In contrast, for unsuccessful BW and MW shocks of the same shock strengths, the VmP and CaiP were not significantly different. MW shocks more frequently created regions of low Cai surrounded by regions of high Cai (postshock Cai sinkholes). The defibrillation threshold for MW and BW shocks became similar after disabling the sarcoplasmic reticulum with thapsigargin and ryanodine. Conclusions The greater efficacy of BW shocks is directly related to their less heterogeneous effects on shock-induced sarcoplasmic reticulum Ca release and Cai transients. Less heterogeneous Cai transients reduces the probability of Cai sinkhole formation, thereby preventing the postshock reinitiation of VF. PMID:18755345
Pan, Fengjuan; Li, Xiaohui; Lu, Fengqi; Wang, Xiaoming; Cao, Jiang; Kuang, Xiaojun; Véron, Emmanuel; Porcher, Florence; Suchomel, Matthew R; Wang, Jing; Allix, Mathieu
2015-09-21
Ordering of interpolated Ba(2+) chains and alternate Ta-O rows (TaO)(3+) in the pentagonal tunnels of tetragonal tungsten bronzes (TTB) is controlled by the nonstoichiometry in the highly nonstoichiometric Ba0.5-xTaO3-x system. In Ba0.22TaO2.72, the filling of Ba(2+) and (TaO)(3+) groups is partially ordered along the ab-plane of the simple TTB structure, resulting in a √2-type TTB superstructure (Pbmm), while in Ba0.175TaO2.675, the pentagonal tunnel filling is completely ordered along the b-axis of the simple TTB structure, leading to a triple TTB superstructure (P21212). Both superstructures show completely empty square tunnels favoring Ba(2+) conduction and feature unusual accommodation of Ta(5+) cations in the small triangular tunnels. In contrast with stoichiometric Ba6GaTa9O30, which shows linear thermal expansion of the cell parameters and monotonic decrease of permittivity with temperature within 100-800 K, these TTB superstructures and slightly nonstoichiometric simple TTB Ba0.4TaO2.9 display abnormally broad and frequency-dependent extrinsic dielectric relaxations in 10(3)-10(5) Hz above room temperature, a linear deviation of the c-axis thermal expansion around 600 K, and high dielectric permittivity ∼60-95 at 1 MHz at room temperature.
Potvin Kent, Monique; Dubois, Lise; Wanless, Alissa
2011-10-01
To examine the efficacy of self-regulation of food marketing to children by comparing, during children's preferred viewing on television, the differences in food/beverage marketing between two groups of corporations: 17 corporations participating in the Canadian Children's Food and Beverage Advertising Initiative (CAI) and 35 corporations not participating (non-CAI) in this initiative. The food/beverage marketing activities of CAI and non-CAI corporations during 99.5 hours of children's preferred viewing on television were compared. First, the preferred television viewing of 272 children aged 10-12 years from Ontario and Quebec who completed TV viewing journals for a seven-day period was determined. A total of 32 television stations were simultaneously recorded, and a content analysis of children's preferred viewing was conducted and included coding all food/beverage promotions and their nutritional content. Each food/beverage promotion was classified by corporation type (i.e., CAI or non-CAI). The CAI was responsible for significantly more food/beverage promotions, and used media characters and repetition more frequently in their food/beverage promotions than the non-CAI group. Nutritionally, the CAI food/beverage promotions were higher in fats, sugar, sodium and energy per 100 grams. A significantly greater proportion of the CAI food/beverage promotions were considered 'less healthy' compared to the non-CAI promotions. With the exception of the four corporations that did not market to children at all, the commitments that have been made in the CAI are not having a significant impact on the food and beverage marketing environment on television which is viewed by 10-12-year-olds.
Al-Mg isotopic evidence for episodic alteration of Ca-Al-rich inclusions from Allende
NASA Astrophysics Data System (ADS)
Fagan, T. J.; Guan, Y.; MacPherson, G. J.
2007-08-01
Textures, mineral assemblages, and Al-Mg isotope systematics indicate a protracted, episodic secondary mineralization history for Allende Ca-Al-rich inclusions (CAIs). Detailed observations from one type B1 CAI, one B2, one compact type A (CTA), and one fluffy type A (FTA) indicate that these diverse types of CAIs are characterized by two distinct textural and mineralogic types of secondary mineralization: (1) grossular-rich domains, concentrated along melilite grain boundaries in CAI interiors, and (2) feldspathoid-bearing domains, confined mostly to CAI margins just interior to the Wark-Lovering rim sequence. The Al-Mg isotopic compositions of most secondary minerals in the type B1 CAI, and some secondary minerals in the other CAIs, show no resolvable excesses of 26Mg, whereas the primary CAI phases mostly yield correlated excesses of 26Mg with increasing Al/Mg corresponding to "canonical" initial 26Al/27Al ˜ 4.5-5 × 10-5. These secondary minerals formed at least 3 Ma after the primary CAI minerals. All but two analyses of secondary minerals from the fluffy type-A CAI define a correlated increase in 26Mg/24Mg with increasing Al/Mg, yielding (26Al/27Al)0 = (4.9 ± 2.8) × 10-6. The secondary minerals in this CAI formed 1.8-3.2 Ma after the primary CAI minerals. In both cases, the timing of secondary alteration is consistent with, but does not necessarily require, alteration in an asteroidal setting. One grossular from the type B2 CAI, and several grossular and secondary feldspar analyses from the compact type A CAI, have excesses of 26Mg consistent with initial 26Al/27Al ˜ 4.5 × 10-5. Especially in the compact type A CAI, where 26Mg/24Mg in grossular correlates with increasing Al/Mg, these 26Mg excesses are almost certainly due to in situ decay of 26Al. They indicate a nebular setting for formation of the grossular. The preservation of these diverse isotopic patterns indicates that heating on the Allende parent body was not pervasive enough to reset isotopic
1975-10-01
MANAOS SAO PAULO AND LIMA* »ääS»«SS8 rÄS^’sSi&.-ja sa."»«- RIO DE JANEIRO IS IN SOUTHEASTERN BRAZIL IT IS ON GUANABARA BAY AND THE ATLANTIC...Administration, or Environmental Protection Agency. Other options that will give you greater selectivity are available on request. The cost o5 SRIM s...concentrating on one aspect at a time. Based on our analyses, we propose in this paper several hypotheses about how the tutor relates his teaching to
Retina and Nerve Fiber Layer Thickness in Eyes with Thyroid-Associated Ophthalmopathy.
Blum Meirovitch, Sharon; Leibovitch, Igal; Kesler, Anat; Varssano, David; Rosenblatt, Amir; Neudorfer, Meira
2017-05-01
Thyroid-associated ophthalmopathy (TAO) is an inflammatory disease that affects the thyroid gland and the eye orbit. Of patients with TAO, 3%-5% have severe sight-threatening disease due to optic neuropathy Optical coherence tomography (OCT), the non-invasive imaging technology that yields high-resolution cross-sectional images of the retina, provides qualitative and quantitative data on the retina. To apply this technique to quantitatively assess retinal nerve fiber layer (RNFL) and macular ring thicknesses in healthy subjects and in patients with TAO to determine their relationship to the severity of the orbital disease. All patients in the ophthalmology clinic who were diagnosed with TAO and underwent OCT imaging as part of their ocular examination comprised the study group, and healthy patients who volunteered to undergo OCT examination served as controls. Results of the complete ophthalmologic examination and OCT findings were collected from medical files, including the thickness of the RNFL and the macula. The study comprised 21 patients and 41 healthy controls. TAO patients exhibited RNFL thickening and inner macula thinning compared to healthy subjects. Mean RNFL thickness was correlated with the severity of the orbital disease. The OCT findings suggest that the retina is involved in TAO, probably as early as the subclinical stage. This highlights the ability of OCT to identify retinal changes earlier and far more accurately than is detected today, enabling earlier diagnosis and more timely treatment to prevent severe visual sequelae.
Feedback and Feedforward Control During Walking in Individuals With Chronic Ankle Instability.
Yen, Sheng-Che; Corkery, Marie B; Donohoe, Amy; Grogan, Maddison; Wu, Yi-Ning
2016-09-01
Study Design Controlled laboratory study. Background Recurrent ankle sprains associated with chronic ankle instability (CAI) occur not only in challenging sports but also in daily walking. Understanding whether and how CAI alters feedback and feedforward controls during walking may be important for developing interventions for CAI prevention or treatment. Objective To understand whether CAI is associated with changes in feedback and feedforward control when individuals with CAI are subjected to experimental perturbation during walking. Methods Twelve subjects with CAI and 12 control subjects walked on a treadmill while adapting to external loading that generated inversion perturbation at the ankle joint. Ankle kinematics around heel contact during and after the adaptation were compared between the 2 groups. Results Both healthy and CAI groups showed an increase in eversion around heel contact in early adaptation to the external loading. However, the CAI group adapted back toward the baseline, while the healthy controls showed further increase in eversion in late adaptation. When the external loading was removed in the postadaptation period, healthy controls showed an aftereffect consisting of an increase in eversion around heel contact, but the CAI group showed no aftereffect. Conclusion The results provide preliminary evidence that CAI may alter individuals' feedback and feedforward control during walking. J Orthop Sports Phys Ther 2016;46(9):775-783. Epub 5 Aug 2016. doi:10.2519/jospt.2016.6403.
ERIC Educational Resources Information Center
International Business Machines Corp., Gaithersburg, MD. Federal Systems Div.
A study of computer-assisted instruction (CAI) for US Army basic electronics training at the US Army Signal Center and School establishes the feasibility of CAI as a training technique. Three aspects of CAI are considered: effectiveness, efficiency, and applicability of CAI to basic electronics training. The study explores the effectiveness of the…
NASA Astrophysics Data System (ADS)
Shollenberger, Quinn R.; Borg, Lars E.; Render, Jan; Ebert, Samuel; Bischoff, Addi; Russell, Sara S.; Brennecka, Gregory A.
2018-05-01
Calcium-aluminum-rich inclusions (CAIs) are the oldest dated materials in the Solar System and numerous previous studies have revealed nucleosynthetic anomalies relative to terrestrial rock standards in many isotopic systems. However, most of the isotopic data from CAIs has been limited to the Allende meteorite and a handful of other CV3 chondrites. To better constrain the isotopic composition of the CAI-forming region, we report the first Sr, Mo, Ba, Nd, and Sm isotopic compositions of two CAIs hosted in the CK3 desert meteorites NWA 4964 and NWA 6254 along with two CAIs from the CV3 desert meteorites NWA 6619 and NWA 6991. After consideration of neutron capture processes and the effects of hot-desert weathering, the Sr, Mo, Ba, Nd, and Sm stable isotopic compositions of the samples show clearly resolvable nucleosynthetic anomalies that are in agreement with previous results from Allende and other CV meteorites. The extent of neutron capture, as manifested by shifts in the observed 149Sm-150Sm isotopic composition of the CAIs is used to estimate the neutron fluence experienced by some of these samples and ranges from 8.40 × 1013 to 2.11 × 1015 n/cm2. Overall, regardless of CAI type or host meteorite, CAIs from CV and CK chondrites have similar nucleosynthetic anomalies within analytical uncertainty. We suggest the region that CV and CK CAIs formed was largely uniform with respect to Sr, Mo, Ba, Nd, and Sm isotopes when CAIs condensed and that CAIs hosted in CV and CK meteorites are derived from the same isotopic reservoir.
Tsuyuki, Kenichiro; Miura, Satoru; Idris, Nasrullah; Kurniawan, Koo Hendrik; Lie, Tjung Jie; Kagawa, Kiichiro
2006-01-01
An experiment to investigate the potential of a laser-induced plasma method for determining concrete compressive strength was conducted by focusing a Nd:YAG laser on concrete samples with different degrees of compressive strength. This technique was developed in light of the role of the shock wave in the generation of a laser-induced plasma. It was found that the speed of the shock front depends on the hardness of the sample. It was also found that a positive relationship exists between the speed of the shock front and the ionization rate of the ablated atoms. Hence, the ratio of the intensity between the Ca(II) 396.8 nm and Ca(I) 422.6 nm emission lines detected from the laser-induced plasma can be used to examine the hardness of the material. In fact, it was observed that the ratio changes with respect to the change in the concrete compressive strength. The findings also show that the ratio increases with time after the cement is mixed with water.
NASA Astrophysics Data System (ADS)
Krot, Alexander N.; Nagashima, Kazuhide; van Kooten, Elishevah M. M.; Bizzarro, Martin
2017-03-01
We describe the mineralogy, petrology and oxygen isotopic compositions of high-temperature rims around mineralogically pristine calcium-aluminum-rich inclusions (CAIs) from the CR, CB and CH carbonaceous chondrites. In CR chondrites, nearly all CAIs are surrounded by single- or multi-layered rims composed of CAI-like minerals; relict CAIs inside chondrules in which the rims were resorbed by the host chondrule melt (Aléon et al., 2002; Makide et al., 2009) are the only exception. A complete multi-layered rim sequence (from inside outward: spinel + hibonite + perovskite → melilite → anorthite replacing melilite → Al-diopside → forsterite) is rarely observed; Al-diopside ± forsterite rims are more common. The CR CAIs and all rim layers are uniformly 16O-rich (Δ17O ∼-24‰), indicating formation in a 16O-rich gaseous reservoir. The mineralogy, petrology and 16O-rich compositions of these rims suggest formation by evaporation/condensation, melting (?), and thermal annealing in the formation region of the host CAIs. We define such rims as the primordial Wark-Lovering (WL) rims. In CH chondrites, most CAIs are uniformly 16O-rich and surrounded by the primordial WL rims. One of the 16O-rich CAIs is surrounded by an anorthite-Al-diopside WL rim showing a range of Δ17O values, from ∼-24‰ to ∼-6‰; Δ17O decreases towards the CAI core. We infer that this rim experienced incomplete melting and O-isotope exchange in an 16O-poor nebular gas, most likely during chondrule formation. Most CAIs in CB chondrites and about 10% of CAIs in CH chondrites are uniformly 16O-depleted igneous inclusions; Δ17O values between individual CAIs vary from ∼-12‰ to ∼-5‰. These CAIs have diverse mineralogies (grossite-rich, hibonite-rich, melilite-rich, spinel-rich, and Al,Ti-diopside ± forsterite-rich), but are surrounded by the mineralogically similar igneous rims composed of ±melilite, Al-diopside and Ca-rich forsterite (0.5-1.4 wt% CaO). The igneous rims and the
NASA Astrophysics Data System (ADS)
Krot, Alexander N.; Nagashima, Kazuhide; van Kooten, Elishevah M. M.; Bizzarro, Martin
2017-03-01
We report on the mineralogy, petrography, and O-isotope compositions of ∼60 Ca, Al-rich inclusions (CAIs) incompletely melted during formation of porphyritic chondrules from the CH metal-rich carbonaceous chondrites and Isheyevo (CH/CB). These include (i) relict polymineralic CAIs in porphyritic chondrules, (ii) CAIs surrounded by chondrule-like igneous rims, (iii) igneous pyroxene-rich and Type C-like CAIs, and (iv) plagioclase-rich chondrules with clusters of relict spinel grains. 26Al-26Mg systematics were measured in 10 relict CAIs and 11 CAI-bearing plagioclase-rich chondrules. Based on the mineralogy, the CH CAIs incompletely melted during chondrule formation can be divided into grossite-rich (n = 13), hibonite-rich (n = 11), spinel ± melilite-rich (n = 33; these include plagioclase-rich chondrules with clusters of relict spinel grains) types. Mineralogical observations indicate that these CAIs were mixed with different proportions of ferromagnesian silicates and experienced incomplete melting and gas-melt interaction during chondrule formation. These processes resulted in partial or complete destruction of the CAI Wark-Lovering rims, replacement of melilite by Na-bearing plagioclase, and dissolution and overgrowth of nearly end-member spinel by chromium- and iron-bearing spinel. Only two relict CAIs and two CAI-bearing chondrules show resolvable excess of radiogenic 26Mg; the inferred initial 26Al/27Al ratios are (1.7 ± 1.3) × 10-6, (3.7 ± 3.1) × 10-7, (1.9 ± 0.9) × 10-6 and (4.9 ± 2.6) × 10-6. There is a large range of Δ17O among the CH CAIs incompletely melted during chondrule formation, from ∼-37‰ to ∼-5‰; the unmelted minerals in individual CAIs, however, are isotopically uniform and systematically 16O-enriched relative to the host chondrules and chondrule-like igneous rims, which have Δ17O ranging from ∼-7‰ to ∼+4‰. Most of the CH CAIs incompletely melted during chondrule formation are mineralogically and isotopically
Evaluation of Computer-Aided Instruction in a Gross Anatomy Course: A Six-Year Study
ERIC Educational Resources Information Center
McNulty, John A.; Sonntag, Beth; Sinacore, James M.
2009-01-01
Web-based computer-aided instruction (CAI) has become increasingly important to medical curricula. This multi-year study investigated the effectiveness of CAI and the factors affecting level of individual use. Three CAI were tested that differed in specificity of applicability to the curriculum and in the level of student interaction with the CAI.…
Computer Assisted Instruction: A Review of the Reviews. Research Report 85-01.
ERIC Educational Resources Information Center
Stennett, R. G.
This review of the literature on computer assisted instruction (CAI) focuses on the use of CAI with grades K-13, and specifically assesses the relative merits of traditional instruction and CAI in promoting student achievement. Also assessed are the applications of CAI in the area of special education. Three types of reviews are used exclusively:…
The Effect of an Intelligent Tutoring System (ITS) on Student Achievement in Algebraic Expression
ERIC Educational Resources Information Center
Chien, Tsai Chen; Md. Yunus, Aida Suraya; Ali, Wan Zah Wan; Bakar, Ab. Rahim
2008-01-01
In this experimental study, use of Computer Assisted Instruction (CAI) followed by use of an Intelligent Tutoring System (CAI+ITS) was compared to the use of CAI (CAI only) in tutoring students on the topic of Algebraic Expression. Two groups of students participated in the study. One group of 32 students studied algebraic expression in a CAI…
NASA Astrophysics Data System (ADS)
Pell, Jennifer; Russell, James K.; Zhang, Shunxin
2018-03-01
Kimberlite pipes from Chidliak, Baffin Island, Nunavut, Canada host surface-derived Paleozoic carbonate xenoliths containing conodonts. Conodonts are phosphatic marine microfossils that experience progressive, cumulative and irreversible colour changes upon heating that are experimentally calibrated as a conodont colour alteration index (CAI). CAI values permit us to estimate the temperatures to which conodont-bearing rocks have been heated. Conodonts have been recovered from 118 samples from 89 carbonate xenoliths collected from 12 of the pipes and CAI values within individual carbonate xenoliths show four types of CAI distributions: (1) CAI values that are uniform throughout the xenolith; (2) lower CAIs in core of a xenolith than the rim; (3) CAIs that increase from one side of the xenolith to the other; and, (4) in one xenolith, higher CAIs in the xenolith core than at the rim. We have used thermal models for post-emplacement conductive cooling of kimberlite pipes and synchronous heating of conodont-bearing xenoliths to establish the temperature-time history of individual xenoliths within the kimberlite bodies. Model results suggest that the time-spans for xenoliths to reach the peak temperatures recorded by CAIs varies from hours for the smallest xenoliths to 2 or 3 years for the largest xenoliths. The thermal modelling shows the first three CAI patterns to be consistent with in situ conductive heating of the xenoliths coupled to the cooling host kimberlite. The fourth pattern remains an anomaly.
Calcium and titanium isotopes in refractory inclusions from CM, CO, and CR chondrites
NASA Astrophysics Data System (ADS)
Kööp, Levke; Davis, Andrew M.; Krot, Alexander N.; Nagashima, Kazuhide; Simon, Steven B.
2018-05-01
Previous studies have shown that CV and CM chondrites incorporated Ca, Al-rich inclusions (CAIs) with different isotopic characteristics, which may represent different snapshots in the isotopic evolution of the early Solar System. To better understand how the isotopic characteristics of CAIs vary between different chondrite groups, we have studied calcium and titanium isotopes in CAIs from CM, CO, and CR chondrites. We show that all three chondrite groups contain CAIs with large anomalies in 48Ca and/or 50Ti (10s of ‰ or 100s of ε-units) as well as CAIs with no anomalies resolved beyond measurement uncertainties. Isotopically, the anomalous CO and CR chondrite CAIs resemble the platy hibonite crystals (PLACs) from CM chondrites, but they are more mineralogically complex. The new data are consistent with the well-established mutual exclusivity relationship between incorporation of 26Al and the presence of large anomalies in 48Ca and 50Ti. The two highly anomalous CO chondrite CAIs have correlated anomalies in 46Ti and 50Ti, while most other highly anomalous CAIs do not. This result could indicate that the reservoir with coupled 46Ti and 50Ti that was sampled by bulk meteorites and CV chondrite CAIs already existed before arrival and/or homogeneous distribution of 26Al in the protoplanetary disk. Among the studied CM chondrite CAIs are ten spinel-hibonite inclusions (SHIBs) with known oxygen isotopic compositions. Our results show that these objects sampled a reservoir that was well-mixed in oxygen, calcium, and titanium isotopes. We further show that SHIBs tend to be slightly enriched in the heavy calcium isotopes, suggesting that their formation history was different from CV chondrite CAIs.
Charge Transport and the Nature of Traps in Oxygen Deficient Tantalum Oxide.
Gritsenko, Vladimir A; Perevalov, Timofey V; Voronkovskii, Vitalii A; Gismatulin, Andrei A; Kruchinin, Vladimir N; Aliev, Vladimir Sh; Pustovarov, Vladimir A; Prosvirin, Igor P; Roizin, Yakov
2018-01-31
Optical and transport properties of nonstoichiometric tantalum oxide thin films grown by ion beam deposition were investigated in order to understand the dominant charge transport mechanisms and reveal the nature of traps. The TaO x films composition was analyzed by X-ray photoelectron spectroscopy and by quantum-chemistry simulation. From the optical absorption and photoluminescence measurements and density functional theory simulations, it was concluded that the 2.75 eV blue luminescence excited in a TaO x by 4.45 eV photons, originates from oxygen vacancies. These vacancies are also responsible for TaO x conductivity. The thermal trap energy of 0.85 eV determined from the transport experiments coincides with the half of the Stokes shift of the blue luminescence band. It is argued that the dominant charge transport mechanism in TaO x films is phonon-assisted tunneling between the traps.
The Chronology of Asteroid Accretion, Differentiation, and Secondary Mineralization
NASA Technical Reports Server (NTRS)
Nyquist, L. E.; Kleine, T.; Shih, C.-Y.; Reese, Y. D.
2008-01-01
We evaluate initial (Al-26/Al-27)(sub I), (Mn-53/Mn-55)(sub I), (Hf-182/Hf-180)(sub I), and Pb-207/Pb-206 ages for igneous differentiated meteorites and chondrules from ordinary chondrites for consistency with radioactive decay of the parent nuclides within a common, closed isotopic system, i.e., the early solar nebula. We find that the relative abundances of Al-26, Mn-53, and Hf-182, here denoted by I(Al)(sub CAI, I(Mn)(sub CAI) and I(Hf)(sub CAI), are consistent with decay from common initial values for the bulk solar system. I(Mn)(sub CAI) and I(Hf)(sub CAI) = 9.1+/-1.7 x 10(exp -6) and 1.06+/-0.09 x 10(exp -6) respectively, correspond to the canonical value of I(Al)(sub CAI) = 5.1 x 10(exp -5). I(Hf)(sub CAI) thus determined is consistent with I(Hf)(sub CAI) = 1.003+/-0.045 x 10(exp -6) directly determined in separate work. I(Mn)(sub CAI) is within error of the lowest value directly determined for CAI. We suggest that erratically higher values directly determined for CAI in carbonaceous chondrites reflect proton irradiation of unaccreted CAIs by the early Sun after other asteroids destined for melting by Al-26 decay had already accreted. The Mn-53 incorporated within such asteroids would have been shielded from further "local" spallogenic contributions. The relative abundances of the short-lived nuclides are less consistent with the Pb-207/Pb-206 ages of the corresponding materials with the best consistency being obtained between (Hf-182/Hf-180)(sub I) and Pb-207/Pb-206 ages of angrites. (Hf-182/Hf-180)(sub I) decreases with decreasing Pb-207/Pb-206 ages at the rate expected from the 8.90+/-0.09 Ma half-life of Hf-182. However, the model "CAI age" thus determined, T(sub CAI,Mn-W) = 4568.6+/-0.7 Ma, is older than the commonly accepted directly measured value T(sub CAI) = 4567.l+/-0.2 Ma. I(Al)(sub I), and (Mn-53/Mn-55)(sub I) are less consistent with Pb-207/Pb-206 ages, but determine T(sub CAI, Mn-Cr) = 4568.3+/-0.5 Ma relative to I(AI)(sub CAI)= 5.1 x 10(exp -5
Etiopathogenesis, clinical diagnosis and treatment of thromboangiitis obliterans – current practices
Joviliano, Edwaldo Edner; Dellalibera-Joviliano, Renata; Dalio, Marcelo; Évora, Paulo RB; Piccinato, Carlos E
2009-01-01
Thromboangiitis obliterans (TAO) is a segmental inflammatory occlusive disorder that affects small- and medium-sized arteries, and arm and leg veins of young smokers. Several different diagnostic criteria have been offered for the diagnosis of TAO. Clinically, it manifests as migratory thrombophlebitis or signs of arterial insufficiency in the extremities. It is characterized by highly cellular and inflammatory occlusive thrombi, primarily of the distal extremities. Thromboses are often occlusive and sometimes display moderate, nonspecific inflammatory infiltrate, consisting mostly of polymorphonuclear leukocytes, mononuclear cells and rare multinuclear giant cells. The immune system appears to play a critical role in the etiology of TAO. However, knowledge about immunological aspects involved in the progression of vascular tissue inflammation, and consequently, the evolution of this disease, is still limited. There are several studies that suggest the involvement of genetic factors and results have shown increasing levels of antiendothelial cell antibodies in patients with active disease. Vasodilation is impaired in patients with TAO. TAO disorder may actually be an autoimmune disorder, probably initiated by an unknown antigen in the vascular endothelium, possibly a component of nicotine. There are various therapies available for treatment of TAO, but the major and indispensable measure is smoking cessation. Except for discontinuation of tobacco use, no forms of therapy are definitive. Sympathectomy, cilostazol and prostaglandin analogues (prostacyclin or prostaglandin E) have been used in specific conditions. Recently, therapeutic angiogenesis with autologous transplantation of bone marrow mononuclear cells has been studied in patients with critical limb ischemia. PMID:22477511
Yoon, Jin Sook; Choi, Soo Hyun; Lee, Joon H; Lee, Sung Jun; Lee, Sang Yeul
2010-02-01
To measure tear nerve growth factor (NGF) concentrations in cases of active thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid treatment, and to correlate NGF levels with disease inflammatory activity and thyroid autoantibody concentration. The study involved 20 patients with active TAO and 20 age- and gender-matched controls. Tear break-up time (BUT) was obtained, the Schirmer test was performed, and tear NGF/total protein ratio was measured in control subjects and patients with active TAO before, and 2 and 4 weeks after, steroid treatment. Tear BUT and Schirmer values significantly increased after 2 and 4 weeks of steroid treatment (p < 0.001 and p = 0.004 respectively). Baseline tear NGF/total protein ratio was higher in patients with active TAO than in control subjects, and the ratio significantly decreased after 2 and 4 weeks of steroid treatment (p < 0.001). Tear NGF/total protein ratio did not correlate with inflammatory activity score, exophthalmos value and thyroid binding inhibiting immunoglobulin (TBII) level (p > 0.05). Tear NGF may have a specific role in ocular surface inflammation, which protects against ocular surface damage in patients with active TAO. Anti-inflammatory treatment significantly reduced the level of NGF in tears, increased tear film stability and production, and decreased congestive symptoms.
NASA Astrophysics Data System (ADS)
Ford, Gregory Scott
2007-12-01
Title. Effect of computer-aided instruction versus traditional modes on student PT's learning musculoskeletal special tests. Problem. Lack of quantitative evidence to support the use of computer-aided instruction (CAI) in PT education for both the cognitive and psychomotor domains and lack of qualitative support as to an understanding why CAI may or may not be effective. Design. 3 group single-blind pre-test, immediate post-test, final post-test repeated measures with qualitative survey for the CAI group. Methods. Subjects were randomly assigned to CAI, live demonstration or textbook learning groups. Three novel special tests were instructed. Analysis of performance on written and practical examinations was conducted across the 3 repeated measures. A qualitative survey was completed by the CAI group post intervention. Results. CAI is equally as effective as live demonstration and textbook learning of musculoskeletal special tests in the cognitive domain, however, CAI was superior to live demonstration and textbook instruction at final post-testing. Significance. The significance of this research is that a gap in the literature of PT education needs to be bridged as it pertains to the effect of CAI on learning in both the cognitive and psychomotor domains as well as attempt to understand why CAI results in certain student performance. The methods of this study allowed for a wide range of generalizability to any and all PT programs across the country.
Effect of taping on foot kinematics in persons with chronic ankle instability.
Deschamps, Kevin; Dingenen, Bart; Pans, Femke; Van Bavel, Isabelle; Matricali, Giovanni Arnoldo; Staes, Filip
2016-07-01
To investigate differences in rigid-foot and multi-segmental foot kinematics between healthy (control) and chronic ankle instability (CAI) participants during running and to evaluate the effect of low-Dye (LD) and high-Dye (HD) taping on foot kinematics of CAI subjects. Cross-sectional, comparative study. Kinematic data of 12 controls and 15 CAI participants were collected by a 3D motion analysis system during running. CAI participants performed barefoot (CAI_BF) running trials as well as trials with taping. A rigid Plug-in gait Model and the Rizzoli 3D Multi-Segment Foot Model were used. Groups were compared using one-dimensional statistical parametric mapping. An increased inversion, a decreased dorsiflexion between the foot and tibia and a decreased external foot progression angle were found during terminal swing and early stance in the CAI_BF group. With respect to the taped conditions, post-hoc SPM{t} calculations highlighted a more dorsiflexed rearfoot (38-46% running cycle) in the CAI_HD compared to the CAI_LD, and a more inverted Mid-Met angle (6-24% running cycle) in the CAI_LD compared to the CAI_BF condition. This study revealed significant differences in rigid foot and multi-segmental foot kinematics between all groups. As high-dye taping embraces shank-rearfoot and forefoot, it seems to have better therapeutic features with respect to low-dye taping as the latter created a more inverted forefoot which may not be recommended in this population. Copyright © 2015 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
Contributing factors to chronic ankle instability.
Hubbard, Tricia J; Kramer, Lauren C; Denegar, Craig R; Hertel, Jay
2007-03-01
The development of repetitive ankle sprains and persistent symptoms after initial ankle sprain has been termed chronic ankle instability (CAI). There is no clear indication of which measures are most important in discriminating between individuals with and without CAI. Thirty subjects with unilateral CAI and controls had measures of ankle laxity and hypomobility, static and dynamic balance, ankle and hip strength, lower extremity alignments, and flexibility taken on both limbs. Based on comparisons of CAI ankles and side-matched limbs in controls, the measures significantly predictive of CAI were increased inversion laxity (r(2) change = 0.203), increased anterior laxity (r(2) change = 0.11), more missed balance trials (r(2) change = 0.094), and lower plantarflexion to dorsiflexion peak torque (r(2) change = 0.052). Symmetry indices comparing the side-to-side differences of each measure also were calculated for each dependent variable and compared between groups. The measures significantly predictive of CAI were decreased anterior reach (r(2) change = 0.185), decreased plantarflexion peak torque (r(2) change = 0.099), decreased posterior medial reach (r(2) change = 0.094), and increased inversion laxity (r(2) change = 0.041). The results of this study elucidate the specific measures that best discriminate between individuals with and without CAI. Both mechanical (anterior and inversion laxity) and functional (strength, dynamic balance) insufficiencies significantly contribute to the etiology of CAI. Prevention of CAI may be possible with proper initial management of the acute injury with rehabilitation aimed at those factors that best discriminate between individuals with and without CAI.
Foreman, K Bo; Morton, David A; Musolino, Gina Maria; Albertine, Kurt H
2005-07-01
The cadaver continues to be the primary tool to teach human gross anatomy. However, cadavers are not available to students outside of the teaching laboratory. A solution is to make course content available through computer-assisted instruction (CAI). While CAI is commonly used as an ancillary teaching tool for anatomy, use of screen space, annotations that obscure the image, and restricted interactivity have limited the utility of such teaching tools. To address these limitations, we designed a Web-based CAI tool that optimizes use of screen space, uses annotations that do not decrease the clarity of the images, and incorporates interactivity across different operating systems and browsers. To assess the design and utility of our CAI tool, we conducted a prospective evaluation of 43 graduate students enrolled in neuroanatomy taught by the Divisions of Physical and Occupational Therapy at the University of Utah, College of Health. A questionnaire addressed navigation, clarity of the images, benefit of the CAI tool, and rating of the CAI tool compared to traditional learning tools. Results showed that 88% of the respondents strongly agreed that the CAI tool was easy to navigate and overall beneficial. Eighty-four percent strongly agreed that the CAI tool was educational in structure identification and had clear images. Furthermore, 95% of the respondents thought that the CAI tool was much to somewhat better than traditional learning tools. We conclude that the design of a CAI tool, with minimal limitations, provides a useful ancillary tool for human neuroanatomy instruction. Copyright 2005 Wiley-Liss, Inc.
Plant growth-promoting activities of Streptomyces spp. in sorghum and rice.
Gopalakrishnan, Subramaniam; Srinivas, Vadlamudi; Sree Vidya, Meesala; Rathore, Abhishek
2013-01-01
Five strains of Streptomyces (CAI-24, CAI-121, CAI-127, KAI-32 and KAI-90) were earlier reported by us as biological control agents against Fusarium wilt of chickpea caused by Fusarium oxysporum f. sp. ciceri (FOC). In the present study, the Streptomyces were characterized for enzymatic activities, physiological traits and further evaluated in greenhouse and field for their plant growth promotion (PGP) of sorghum and rice. All the Streptomyces produced lipase, β-1-3-glucanase and chitinase (except CAI-121 and CAI-127), grew in NaCl concentrations of up to 6%, at pH values between 5 and 13 and temperatures between 20 and 40°C and were highly sensitive to Thiram, Benlate, Captan, Benomyl and Radonil at field application level. When the Streptomyces were evaluated in the greenhouse on sorghum all the isolates significantly enhanced all the agronomic traits over the control. In the field, on rice, the Streptomyces significantly enhanced stover yield (up to 25%; except CAI-24), grain yield (up to 10%), total dry matter (up to 18%; except CAI-24) and root length, volume and dry weight (up to 15%, 36% and 55%, respectively, except CAI-24) over the control. In the rhizosphere soil, the Streptomyces significantly enhanced microbial biomass carbon (except CAI-24), nitrogen, dehydrogenase (except CAI-24), total N, available P and organic carbon (up to 41%, 52%, 75%, 122%, 53% and 13%, respectively) over the control. This study demonstrates that the selected Streptomyces which were antagonistic to FOC also have PGP properties.
Holst, Jesper C.; Olsen, Mia B.; Paton, Chad; Nagashima, Kazuhide; Schiller, Martin; Wielandt, Daniel; Larsen, Kirsten K.; Connelly, James N.; Jørgensen, Jes K.; Krot, Alexander N.; Nordlund, Åke; Bizzarro, Martin
2013-01-01
Refractory inclusions [calcium–aluminum-rich inclusions, (CAIs)] represent the oldest Solar System solids and provide information regarding the formation of the Sun and its protoplanetary disk. CAIs contain evidence of now extinct short-lived radioisotopes (e.g., 26Al, 41Ca, and 182Hf) synthesized in one or multiple stars and added to the protosolar molecular cloud before or during its collapse. Understanding how and when short-lived radioisotopes were added to the Solar System is necessary to assess their validity as chronometers and constrain the birthplace of the Sun. Whereas most CAIs formed with the canonical abundance of 26Al corresponding to 26Al/27Al of ∼5 × 10−5, rare CAIs with fractionation and unidentified nuclear isotope effects (FUN CAIs) record nucleosynthetic isotopic heterogeneity and 26Al/27Al of <5 × 10−6, possibly reflecting their formation before canonical CAIs. Thus, FUN CAIs may provide a unique window into the earliest Solar System, including the origin of short-lived radioisotopes. However, their chronology is unknown. Using the 182Hf–182W chronometer, we show that a FUN CAI recording a condensation origin from a solar gas formed coevally with canonical CAIs, but with 26Al/27Al of ∼3 × 10−6. The decoupling between 182Hf and 26Al requires distinct stellar origins: steady-state galactic stellar nucleosynthesis for 182Hf and late-stage contamination of the protosolar molecular cloud by a massive star(s) for 26Al. Admixing of stellar-derived 26Al to the protoplanetary disk occurred during the epoch of CAI formation and, therefore, the 26Al–26Mg systematics of CAIs cannot be used to define their formation interval. In contrast, our results support 182Hf homogeneity and chronological significance of the 182Hf–182W clock. PMID:23671077
Holst, Jesper C; Olsen, Mia B; Paton, Chad; Nagashima, Kazuhide; Schiller, Martin; Wielandt, Daniel; Larsen, Kirsten K; Connelly, James N; Jørgensen, Jes K; Krot, Alexander N; Nordlund, Ake; Bizzarro, Martin
2013-05-28
Refractory inclusions [calcium-aluminum-rich inclusions, (CAIs)] represent the oldest Solar System solids and provide information regarding the formation of the Sun and its protoplanetary disk. CAIs contain evidence of now extinct short-lived radioisotopes (e.g., (26)Al, (41)Ca, and (182)Hf) synthesized in one or multiple stars and added to the protosolar molecular cloud before or during its collapse. Understanding how and when short-lived radioisotopes were added to the Solar System is necessary to assess their validity as chronometers and constrain the birthplace of the Sun. Whereas most CAIs formed with the canonical abundance of (26)Al corresponding to (26)Al/(27)Al of ∼5 × 10(-5), rare CAIs with fractionation and unidentified nuclear isotope effects (FUN CAIs) record nucleosynthetic isotopic heterogeneity and (26)Al/(27)Al of <5 × 10(-6), possibly reflecting their formation before canonical CAIs. Thus, FUN CAIs may provide a unique window into the earliest Solar System, including the origin of short-lived radioisotopes. However, their chronology is unknown. Using the (182)Hf-(182)W chronometer, we show that a FUN CAI recording a condensation origin from a solar gas formed coevally with canonical CAIs, but with (26)Al/(27)Al of ∼3 × 10(-6). The decoupling between (182)Hf and (26)Al requires distinct stellar origins: steady-state galactic stellar nucleosynthesis for (182)Hf and late-stage contamination of the protosolar molecular cloud by a massive star(s) for (26)Al. Admixing of stellar-derived (26)Al to the protoplanetary disk occurred during the epoch of CAI formation and, therefore, the (26)Al-(26)Mg systematics of CAIs cannot be used to define their formation interval. In contrast, our results support (182)Hf homogeneity and chronological significance of the (182)Hf-(182)W clock.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Boatner, L. A.; Ramey, J. O.; Kolopus, J. A.
2015-02-21
Initially, the alkaline-earth scintillator, CaI 2:Eu 2+, was discovered around 1964 by Hofstadter, Odell, and Schmidt. Serious practical problems quickly arose, however, that were associated with the growth of large monolithic single crystals of this material due to its lamellar, mica-like structure. As a result of its theoretically higher light yield, CaI 2:Eu 2+ has the potential to exceed the excellent scintillation performance of SrI 2:Eu 2+. In fact, theoretical predictions for the light yield of CaI2:Eu 2+ scintillators suggested that an energy resolution approaching 2% at 662 keV could be achievable. Like the early SrI 2:Eu 2+ scintillator, themore » performance of CaI 2:Eu 2+ scintillators has traditionally suffered due, at least in part, to outdated materials synthesis, component stoichiometry/purity, and single-crystal-growth techniques. Based on our recent work on SrI 2:Eu 2+ scintillators in single-crystal form, we have developed new techniques that are applied here to CaI 2:Eu 2+ and pure CaI 2 with the goal of growing large un-cracked crystals and, potentially, realizing the theoretically predicted performance of the CaI 2:Eu 2+ form of this material. Calcium iodide does not adhere to modern glassy carbon Bridgman crucibles - so there should be no differential thermal-contraction-induced crystal/crucible stresses on cooling that would result in crystal cracking of the lamellar structure of CaI 2. Here we apply glassy carbon crucible Bridgman growth, high-purity growth-charge compounds, our molten salt processing/filtration technique, and extended vacuum-melt-pumping methods to the growth of both CaI 2:Eu 2+ and un-doped CaI 2. Moreover, large scintillating single crystals were obtained, and detailed characterization studies of the scintillation properties of CaI 2:Eu 2+ and pure CaI 2 single crystals are presented that include studies of the effects of plastic deformation of the crystals on the scintillator performance.« less
Origin of Spinel Framboids in Calcium-Aluminum-Rich Inclusions
NASA Astrophysics Data System (ADS)
Yoshizaki, T.; Nakashima, D.; Nakamura, T.; Ishida, H.; Sakamoto, N.
2017-07-01
Mineralogical, petrological and O-isotopic study of a CV CAI suggests that spinel framboids in the CAI were originally mini-CAIs that condensed separately under different conditions and subsequently aggregated to form the inclusion.
Choi, Youn-Hee; Back, Keum Ok; Kim, Hee Ja; Lee, Sang Yeul; Kook, Koung Hoon
2013-08-01
The aim of this study was to determine the effect of pirfenidone on interleukin (IL)-1β-induced cyclooxygenase (COX)-2 and prostaglandin (PG)E2 expression in orbital fibroblasts from patients with thyroid-associated ophthalmopathy (TAO). Primary cultures of orbital fibroblasts from patients with TAO (n = 4) and non-TAO subjects (n = 4) were prepared. The level of PGE2 in orbital fibroblasts treated with IL-1β in the presence or absence of pirfenidone was measured using an enzyme-linked immunosorbent assay. The effect of pirfenidone on IL-1β-induced COX-2 expression in orbital fibroblasts from patients with TAO was evaluated by reverse transcription-polymerase chain reaction (PCR) and quantitative real-time PCR analyses, and verified by Western blot. Activation of nuclear factor-κB (NF-κB) was evaluated by immunoblotting for inhibitor of κB (IκB)α and phosphorylated IκBα, and DNA-binding activity of p50/p65 NF-κB was analyzed by electrophoretic mobility shift assay. In addition, IL-1 receptor type 1 (IL-1R1) expression was assessed by RT-PCR in IL-1β-treated cells with or without pirfenidone. Pirfenidone significantly attenuated IL-1β-induced PGE2 release in both TAO and non-TAO cells. IL-1β-induced COX-2 mRNA and protein expression decreased significantly following co-treatment with pirfenidone. IL-1β-induced IκBα phosphorylation and degradation decreased in the presence of pirfenidone and led to decreased nuclear translocation and DNA binding of the active NF-κB complex. In our system, neither IL-1β nor pirfenidone co-treatment influenced IL-1R1 expression. Our results suggest that pirfenidone attenuates the IL-1β-induced PGE2/COX-2 production in TAO orbital fibroblasts, which is related with suppression of the NF-κB activation. Copyright © 2013 Elsevier Ltd. All rights reserved.
Junqueira, Beatriz L P; Connolly, Bairbre; Abla, Oussama; Tomlinson, George; Amaral, Joao G
2010-09-15
The objective of this study was to determine whether severe neutropenia on the day of port-a-catheter (PORT) insertion was a risk factor for catheter-associated infection (CAI) in children with acute lymphoblastic leukemia (ALL). This was a retrospective study of children with ALL who had a PORT insertion between January 2005 and August 2008. Early (≤ 30 days) and late (>30 days) postprocedure complications were reviewed. The length of follow-up ranged between 7 months and 42 months. In total, 192 PORTs were inserted in 179 children. There were 43 CAIs (22%), and the infection rate was 0.35 per 1000 catheter-days. The CAI rate (15%) in children who had severe neutropenia on the day of the procedure did not differ statistically from the CAI rate (24%) in children who did not have severe neutropenia (P = .137). Conversely, patients with severe neutropenia who had a CAI were more likely to have their PORT removed (P = .019). The most common organisms to cause catheter removal were coagulase-negative Staphylococcus and Staphylococcus aureus. Patients with high-risk ALL had a statistically significant higher incidence of late CAI than patients with standard-risk ALL (P = .012). Age (P = .272), positive blood culture preprocedure (P = 1.0), and dexamethasone use (P = .201) were not risk factors for CAI. Patients who had an early CAI did not have a greater chance of having a late CAI. The catheter infection-free survival rate at 1 year was 88.6%. The current results indicated that severe neutropenia on the day of PORT insertion does not increase the risk of CAI in children with ALL. © 2010 American Cancer Society.
Aluminum-Magnesium and Oxygen Isotope Study of Relict Ca-Al-rich Inclusions in Chondrules
NASA Astrophysics Data System (ADS)
Krot, Alexander N.; McKeegan, Kevin D.; Huss, Gary R.; Liffman, Kurt; Sahijpal, Sandeep; Hutcheon, Ian D.; Srinivasan, Gopalan; Bischoff, Adolph; Keil, Klaus
2006-03-01
Relict Ca-Al-rich inclusions (CAIs) in chondrules crystallized before their host chondrules and were subsequently partly melted together with chondrule precursors during chondrule formation. Like most CAIs, relict CAIs are 16O enriched (Δ17O<-20‰) compared to their host chondrules (Δ17O>-9‰). Hibonite in a relict CAI from the ungrouped carbonaceous chondrite Adelaide has a large excess of radiogenic 26Mg (26Mg*) from the decay of 26Al, corresponding to an initial 26Al/27Al ratio [(26Al/27Al)I] of (3.7+/-0.5)×10-5 in contrast, melilite in this CAI and plagioclase in the host chondrule show no evidence for 26Mg* [(26Al/27Al)I of <5×10-6]. Grossite in a relict CAI from the CH carbonaceous chondrite PAT 91546 has little 26Mg*, corresponding to a (26Al/27Al)I of (1.7+/-1.3)×10-6. Three other relict CAIs and their host chondrules from the ungrouped carbonaceous chondrite Acfer 094, CH chondrite Acfer 182, and H3.4 ordinary chondrite Sharps do not have detectable 26Mg* [(26Al/27Al)I<1×10-5, <(4-6)×10-6, and <1.3×10-5, respectively]. Isotopic data combined with mineralogical observations suggest that relict CAIs formed in an 16O-rich gaseous reservoir before their host chondrules, which originated in an 16O-poor gas. The Adelaide CAI was incorporated into its host chondrule after 26Al had mostly decayed, at least 2 Myr after the CAI formed, and this event reset 26Al-26Mg systematics.
Chu, Jen-Hao; Huang, Jiun-Hau
2017-11-28
In recent years, men who have sex with men (MSM) have accounted for over 80% of all new HIV cases in Taiwan. More than 70% of new cases have occurred in those aged 15-34 years. Condomless anal intercourse (CAI) has been identified as the main route of HIV transmission among MSM. To systematically examine CAI intention and associated factors among young MSM in Taiwan, an anonymous online survey based on the Theory of Planned Behavior (TPB) was conducted. Data from 694 MSM aged 15-39 years were included in the analysis. This study found that, overall, all five TPB factors (i.e., attitudes toward positive and negative outcomes regarding CAI, perceived support for CAI from important others, and perceived behavioral control of CAI under facilitating and constraining conditions) were significantly associated with CAI intention. When data were stratified by sexual role (i.e., receptive, versatile, and insertive), the associations between TPB factors and CAI intention varied. Of the five TPB factors, positive attitudes toward positive outcomes regarding CAI were most strongly associated with high CAI intention (AOR 5.68 for all young MSM; AOR 3.80-15.93, depending on sexual role). Findings from this study could inform the development of theory-driven HIV prevention programs as well as future research and practice. These results also highlight the importance of tailoring HIV prevention initiatives for young MSM of different sexual roles to optimize the program effectiveness.
Joung, Boyoung; Park, Hyung-Wook; Maruyama, Mitsunori; Tang, Liang; Song, Juan; Han, Seongwook; Piccirillo, Gianfranco; Weiss, James N.; Lin, Shien-Fong; Chen, Peng-Sheng
2012-01-01
Background Anodal stimulation hyperpolarizes cell membrane and increases intracellular Ca2+ (Cai) transient. This study tested the hypothesis that The maximum slope of Cai decline (–(dCai/dt)max) corresponds to the timing of anodal dip on the strength-interval curve and the initiation of repetitive responses and ventricular fibrillation (VF) after a premature stimulus (S2). Methods and Results We simultaneously mapped membrane potential (Vm) and Cai in 23 rabbit ventricles. A dip was observed on the anodal strength-interval curve. During the anodal dip, ventricles were captured by anodal break excitation directly under the S2 electrode. The Cai following anodal stimuli is larger than that following cathodal stimuli. The S1-S2 intervals of the anodal dip (203 ± 10 ms) coincided with the -(dCai/dt)max (199 ± 10 ms, p=NS). BAPTA-AM (n=3), INCX inhibition by low extracellular Na+ (n=3), and combined ryanodine and thapsigargin infusion (n=2) eliminated the anodal supernormality. Strong S2 during the relative refractory period (n=5) induced 29 repetitive responses and 10 VF episodes. The interval between S2 and the first non-driven beat was coincidental with the time of -(dCai/dt)max. Conclusions Larger Cai transient and INCX activation induced by anodal stimulation produces anodal supernormality. Time of maximum INCX activation is coincidental to the induction of non- driven beats from the Cai sinkhole after a strong premature stimulation. PMID:21301131
Gabriner, Michael L; Braun, Brittany A; Houston, Megan N; Hoch, Matthew C
2015-02-01
Chronic ankle instability (CAI) is a condition commonly experienced by physically active individuals. It has been suggested that foot orthotics may increase a CAI patient's postural control. For patients with CAI, is there evidence to suggest that an orthotic intervention will help improve postural control? The literature was searched for studies of level 2 evidence or higher that investigated the effects of foot orthotics on postural control in patients with CAI. The search of the literature produced 5 possible studies for inclusion; 2 studies met the inclusion criteria and were included. One randomized controlled trial and 1 outcomes study were included. Foot orthotics appear to be effective at improving postural control in patients with CAI. There is moderate evidence to support the use of foot orthotics in the treatment of CAI to help improve postural control. There is grade B evidence that foot orthotics help improve postural control in people with CAI. The Centre of Evidence Based Medicine recommends a grade of B for level 2 evidence with consistent findings.
NASA Astrophysics Data System (ADS)
Boltersdorf, Jonathan; Maggard, Paul A.
2015-09-01
The PbTa4O11 and BiTa7O19 phases were prepared by ion-exchange and solid-state methods, respectively, and their structures were characterized by neutron time-of-flight diffraction and Rietveld refinement methods (PbTa4O11, R 3 (No. 146), a=6.23700(2) Å, c=36.8613(1) Å; BiTa7O19, P 6 bar c 2 (No. 188), a=6.2197(2) Å, c=20.02981(9) Å). Their structures are comprised of layers of TaO6 octahedra surrounded by three 7-coordinate Pb(II) cations or two 8-coordinate Bi(III) cations. These layers alternate down the c-axis with α-U3O8 types of single and double TaO7 pentagonal bipyramid layers. In contrast to earlier studies, both phases are found to crystallize in noncentrosymmetric structures. Symmetry-lowering structural distortions within PbTa4O11, i.e. R 3 bar c →R3, are found to be a result of the displacement of the Ta atoms within the TaO7 and TaO6 polyhedra, towards the apical and facial oxygen atoms, respectively. In BiTa7O19, relatively lower reaction temperatures leads to an ordering of the Bi/Ta cations within a lower-symmetry structure, i.e., P63/mcm→ P 6 bar c 2 . In the absence of Bi/Ta site disorder, the Ta-O-Ta bond angles decrease and the Ta-O bond distances increase within the TaO7 double layers. Scanning electron microscopy images reveal two particle morphologies for PbTa4O11, hexagonal rods and finer irregularly-shaped particles, while BiTa7O19 forms as aggregates of irregularly-shaped particles. Electronic-structure calculations confirm the highest-energy valence band states are comprised of O 2p-orbitals and the respective Pb 6s-orbital and Bi 6s-orbital contributions. The lowest-energy conduction band states are composed of Ta 5d-orbital contributions that are delocalized over the TaO6 octahedra and layers of TaO7 pentagonal bipyramids. The symmetry-lowering distortions in the PbTa4O11 structure, and the resulting effects on its electronic structure, lead to its relatively higher photocatalytic activity compared to similar structures without
Rhenium-osmium systematics of calcium-aluminium-rich inclusions in carbonaceous chondrites
Becker, H.; Morgan, J.W.; Walker, R.J.; MacPherson, G.J.; Grossman, J.N.
2001-01-01
The Re-Os isotopic systematics of calcium-aluminium-rich inclusions (CAIs) in chondrites were investigated in order to shed light on the behavior of the Re-Os system in bulk chondrites, and to constrain the timing of chemical fractionation in primitive chondrites. CAIs with relatively unfractionated rare earth element (REE) patterns (groups I, III, V, VI) define a narrow range of 187Re/188Os (0.3764-0.4443) and 187Os/188Os (0.12599-0.12717), and high but variable Re and Os abundances (3209-41,820 ppb Os). In contrast, CAIs that show depletions in highly refractory elements and strongly fractionated REE patterns (group II) also show a much larger range in 187Re/188Os (0.409-0.535) and 187Os/188Os (0.12695-0.13770), and greater than an order of magnitude lower Re and Os abundances than other groups (e.g., 75.7-680.2 ppb Os). Sixteen bulk CAIs and CAI splits plot within analytical uncertainty of a 4558 Ga reference isochron, as is expected for materials of this antiquity. Eight samples, however, plot off the isochron. Several possible reasons for these deviations are discussed. Data for multiple splits of one CAI indicate that the nonisochronous behavior for at least this CAI is the result of Re-Os reequilibration at approximately 1.6 Ga. Thus, the most likely explanation for the deviations of most of the nonisochronous CAIs is late-stage open-system behavior of Re and Os in the asteroidal environment. The 187Os/188Os-Os systematics of CAIs are consistent with previous models that indicate group II CAIs are mixtures of components that lost the bulk of their highly refractory elements in a previous condensation event and a minor second component that provided refractory elements at chondritic relative proportions. The high Re/Os of group II CAIs relative to other CAIs and chondrite bulk rocks may have been caused by variable mobilization of Re and Os during medium- to low-temperature parent body alteration ??4.5 Ga ago. This model is favored over nebular models, which
Wilson, Patrick A; Kahana, Shoshana Y; Fernandez, Maria Isabel; Harper, Gary W; Mayer, Kenneth; Wilson, Craig M; Hightow-Weidman, Lisa B
2016-02-01
Human immunodeficiency virus (HIV) diagnoses continue to increase among young men who have sex with men (YMSM). Many YMSM living with HIV engage in sexual risk behaviors, and those who have a detectable viral load can transmit HIV to sex partners. Understanding factors that are related to sexual risk taking among virologically detectable (VL+) YMSM can inform prevention and treatment efforts. To describe differences between virologically suppressed (VL-) and VL+ YMSM living with HIV and to identify correlates of condomless anal intercourse (CAI) and serodiscordant CAI among VL+ YMSM. In this cross-sectional survey conducted from December 1, 2009, through June 30, 2012, we studied 991 HIV-infected YMSM 15 to 26 years of age at 20 adolescent HIV clinics in the United States. Data analysis was conducted December 1, 2013, through July 31, 2015. Demographic, behavioral, and psychosocial assessments obtained using audio computer-assisted self-interviews. Viral load information was obtained via blood draw or medical record abstraction. Of the 991 participants, 688 (69.4%) were VL+ and 458 (46.2%) reported CAI, with 310 (31.3%) reporting serodiscordant CAI in the past 3 months. The VL+ YMSM were more likely than the VL- YMSM to report CAI (detectable, 266 [54.7%]; suppressed, 91 [44.4%]; P = .01) and serodiscordant CAI (detectable, 187 [34.9%]; suppressed, 57 [25.0%]; P < .01). Multivariable analyses indicated that among VL+ YMSM, those reporting problematic substance use were more likely to report CAI (adjusted odds ratio [AOR], 1.46; 95% CI, 1.02-2.10) and serodiscordant CAI (AOR, 1.45; 95% CI, 1.06-1.99). Black VL+ YMSM were less likely to report CAI (AOR, 0.63; 95% CI, 0.44-0.90) or serodiscordant CAI (AOR, 0.66; 95% CI, 0.46-0.94) compared with other VL+ YMSM. In addition, VL+ YMSM who disclosed their HIV status to sex partners were more likely to report CAI compared with nondisclosing YMSM (AOR, 1.35; 95% CI, 1.01-1.81). Transgender participants were less likely
DOE Office of Scientific and Technical Information (OSTI.GOV)
MacPherson, G. J.; Bullock, E. S.; Janney, P. E.
2010-03-10
The short-lived radionuclide {sup 26}Al existed throughout the solar nebula 4.57 Ga ago, and the initial abundance ratio ({sup 26}Al/{sup 27}Al){sub 0}, as inferred from magnesium isotopic compositions of calcium-aluminum-rich inclusions (CAIs) in chondritic meteorites, has become a benchmark for understanding early solar system chronology. Internal mineral isochrons in most CAIs measured by secondary ion mass spectrometry (SIMS) give ({sup 26}Al/{sup 27}Al){sub 0} {approx} (4-5) x 10{sup -5}, called 'canonical'. Some recent high-precision analyses of (1) bulk CAIs measured by multicollector inductively coupled plasma mass spectrometry (MC-ICPMS), (2) individual CAI minerals and their mixtures measured by laser-ablation MC-ICPMS, and (3)more » internal isochrons measured by multicollector (MC)-SIMS indicated a somewhat higher 'supracanonical' ({sup 26}Al/{sup 27}Al){sub 0} ranging from (5.85 {+-} 0.05) x 10{sup -5} to >7 x 10{sup -5}. These measurements were done on coarse-grained Type B and Type A CAIs that probably formed by recrystallization and/or melting of fine-grained condensate precursors. Thus the supracanonical ratios might record an earlier event, the actual nebular condensation of the CAI precursors. We tested this idea by performing in situ high-precision magnesium isotope measurements of individual minerals in a fine-grained CAI whose structures and volatility-fractionated trace element abundances mark it as a primary solar nebula condensate. Such CAIs are ideal candidates for the fine-grained precursors to the coarse-grained CAIs, and thus should best preserve a supracanonical ratio. Yet, our measured internal isochron yields ({sup 26}Al/{sup 27}Al){sub 0} = (5.27 {+-} 0.17) x 10{sup -5}. Thus our data do not support the existence of supracanonical ({sup 26}Al/{sup 27}Al){sub 0} = (5.85-7) x 10{sup -5}. There may not have been a significant time interval between condensation of the CAI precursors and their subsequent melting into coarse
NASA Astrophysics Data System (ADS)
Li, Bing; Shi, Xuefa; Wang, Jixin; Yan, Quanshu; Liu, Chenguang; DY125-21 (Leg 3) Science Party; DY125-22 (Legs 2-5) Science Party; DY125-26 (Leg 3) Science Party
2018-05-01
Systematic hydrothermal exploration and multi-beam bathymetry mapping have been conducted along a 220-km-long section of the Southern Mid-Atlantic Ridge (SMAR) from 12°S (Bode Verde Fracture Zone) to 14°S (Cardno Fracture Zone), and previously reported deposits (Tao et al., 2011) are now being thoroughly investigated. Here, we present the characterization of three possible hydrothermal fields, a complete bathymetry data set of the ridge segment, gravity data, and the petrologic characteristics of collected rock samples. The magmatism characteristics, evolution of the ridge segment, and the local geological controls of the possible hydrothermal fields are then discussed. The studied segment can be divided into two segments by a Non-Transform Discontinuity (NTD). Our morphotectonic analysis shows significant along-axis heterogeneity in the surveyed segments: three distinctive cross-axis grabens were identified in the northern segment, and two were identified in the southern segment. Moreover, based on the gravity data (a relatively low spherical Bouguer anomaly) and petrologic data (low Mg# values and relatively low FeO and relatively high Al2O3 and CaO contents compared to nearby seafloor samples), a volcanic feature, the ZouYu seamount, on this segment is considered to be associated with strong magmatic activity, and the magmatic activity of the inside corner at the southern end of the segment has increased and decreased. The three possible hydrothermal fields occur in different local geological settings: a shallow magmatic seamount (ZouYu), an NTD (TaiJi), and an inside-corner high (CaiFan). These potential hydrothermal fields are significantly different from other fields in similar tectonic settings in terms of local geologic controls and products. The ZouYu field is primarily related to a newly formed cone, resulting in the production of sulfides, and differs from other fields on shallow magmatic seamounts. The TaiJi field is largely controlled by the tectonic
Hip strength and star excursion balance test deficits of patients with chronic ankle instability.
McCann, Ryan S; Crossett, Ian D; Terada, Masafumi; Kosik, Kyle B; Bolding, Brenn A; Gribble, Phillip A
2017-11-01
To examine isometric hip strength in those with and without CAI, and determine the degree of Star Excursion Balance Test (SEBT) variance explained by isometric hip strength. Single-blinded, cross-sectional, case-control study. Thirty individuals with CAI, 29 lateral ankle sprain (LAS) copers, and 26 healthy controls participated. We assessed dynamic postural control with the SEBT anterior (SEBT-ANT), posteromedial (SEBT-PM), and posterolateral (SEBT-PL) reaches, and isometric hip extension (EXT), abduction (ABD) and external rotation (ER) strength with hand-held dynamometry. The CAI and LAS coper groups' involved limbs and randomly selected limbs in controls were tested. Separate Kruskal-Wallis tests compared SEBT scores and isometric hip strength between groups. Backwards linear regression models determined the degree of SEBT variance explained by isometric hip strength. Statistical significance was set a priori at P<0.05. The CAI group had lower SEBT-ANT scores compared to LAS copers (P=0.03) and controls (P=0.03). The CAI group had lower ABD compared to LAS copers (P=0.03) and controls (P=0.02). The CAI group had lower ER compared to LAS copers (P=0.01) and controls (P=0.01). ER (R 2 =0.25, P=0.01) and ABD (R 2 =0.25, P=0.01) explained 25% of the CAI group's SEBT-PM and SEBT-PL variances, respectively. The CAI group had deficient dynamic postural control and isometric hip strength compared to LAS copers and controls. Additionally, the CAI group's isometric hip strength significantly influenced dynamic postural control performance. Future CAI rehabilitation strategies should consider hip muscular strengthening to facilitate improvements in dynamic postural control. Copyright © 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
Treatment of common deficits associated with chronic ankle instability.
Holmes, Alison; Delahunt, Eamonn
2009-01-01
Lateral ankle sprains are amongst the most common injuries incurred by athletes, with the high rate of reoccurrence after initial injury becoming of great concern. Chronic ankle instability (CAI) refers to the development of repetitive ankle sprains and persistent residual symptoms post-injury. Some of the initial symptoms that occur in acute sprains may persist for at least 6 months post-injury in the absence of recurrent sprains, despite the athlete having returned to full functional activity. CAI is generally thought to be caused by mechanical instability (MI) or functional instability (FI), or both. Although previously discussed as separate entities, recent research has demonstrated that deficits associated with both MI and FI may co-exist to result in CAI. For clinicians, the main deficits associated with CAI include deficits in proprioception, neuromuscular control, strength and postural control. Based on the literature reviewed, it does seem that subjects with CAI have a deficit in frontal plane ankle joint positional sense. Subjects with CAI do not appear to exhibit any increased latency in the peroneal muscles in response to an external perturbation. Preliminary data suggest that feed-forward neuromuscular control may be more important than feed-back neuromuscular control and interventions are now required to address deficits in feed-forward neuromuscular control. Balance training protocols have consistently been shown to improve postural stability in subjects with CAI. Subjects with CAI do not experience decreased peroneus longus strength, but instead may experience strength deficits in the ankle joint invertor muscles. These findings are of great clinical significance in terms of understanding the mechanisms and deficits associated with CAI. An appreciation of these is vital to allow clinicians to develop effective prevention and treatment programmes in relation to CAI.
Re-Learning of Traditional Knowledge in Times of Modernity
ERIC Educational Resources Information Center
Rosa, Enn
2013-01-01
Purpose: The purpose of this paper is to draw attention to an indigenous community that lives in the periphery of Taiwan. The Tao were confronted with modernization beginning with the Japanese colonial time and later through missionary work and Sinicization. These exogenous factors had a major influence on the Tao's traditional lifestyle and…
Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-20
...; Pueblo of Taos, New Mexico; Pueblo of Tesuque, New Mexico; Pueblo of Zia, New Mexico; Sac & Fox Tribe of the Mississippi in Iowa; Sac & Fox Nation of Missouri in Kansas & Nebraska; Sac & Fox Nation, Oklahoma... Taos, New Mexico; Pueblo of Tesuque, New Mexico; Pueblo of Zia, New Mexico; Sac & Fox Tribe of the...
Refractory materials in comet samples
NASA Astrophysics Data System (ADS)
Joswiak, D. J.; Brownlee, D. E.; Nguyen, A. N.; Messenger, S.
2017-08-01
Transmission electron microscope examination of more than 250 fragments, >1 μm from comet Wild 2 and a giant cluster interplanetary dust particle (GCP) of probable cometary origin has revealed four new calcium-aluminum-rich inclusions (CAIs), an amoeboid olivine aggregate (AOA), and an additional AOA or Al-rich chondrule (ARC) object. All of the CAIs have concentric mineral structures and are composed of spinel + anorthite cores surrounded by Al,Ti clinopyroxenes and are similar to two previous CAIs discovered in Wild 2. All of the cometary refractory objects are of moderate refractory character. The mineral assemblages, textures, and bulk compositions of the comet CAIs are similar to nodules in fine-grained, spinel-rich inclusions (FGIs) found in primitive chondrites and like the nodules may be nebular condensates that were altered via solid-gas reactions in the solar nebula. Oxygen isotopes collected on one Wild 2 CAI also match FGIs. The lack of the most refractory inclusions in the comet samples may reflect the higher abundances of small moderately refractory CAI nodules that were produced in the nebula and the small sample sizes collected. In the comet samples, approximately 2-3% of all fragments larger than 1 μm, by number, are CAIs and nearly 50% of all bulbous Stardust tracks contain at least one CAI. We estimate that 0.5 volume % of Wild 2 material and 1 volume % of GCP is in the form of CAIs. ARCs and AOAs account for <1% of the Wild 2 and GCP grains by number.
Ultra-Refractory Calcium-Aluminum-Rich Inclusion in an AOA in CR Chondrite Yamato-793261
NASA Technical Reports Server (NTRS)
Komatsu, M.; Fagan, T. J.; Yamaguchi, A.; Mikouchi, T.; Yasutake, M.; Zolensky, M. E.
2017-01-01
CR chondrites are a group of primitive carbonaceous chondrites that preserve nebular records of the formation conditions of their components. We have been investigating a set of Antarctic CR chondrites from the Japanese-NIPR collection in order to study variations within this group. During our study, we have found an AOA that encloses an ultrarefractory (UR) CAI in Yamato-793261 (Y-793261). UR CAIs are rare in carbonaceous chondrites, and only three UR CAIs in AOAs have been identified so far. UR CAIs can provide information on crystallization processes at very high temperatures in the solar nebula. Here we describe the petrology of Y-793261, and preliminary results on this newly discovered AOA enclosing a UR CAI.
Lilley, Thomas; Herb, Christopher C; Hart, Joseph; Hertel, Jay
2018-06-01
Chronic ankle instability (CAI) is a condition resulting from a lateral ankle sprain. Shank-rearfoot joint-coupling variability differences have been found in CAI patients; however, joint-coupling variability (VCV) of the ankle and proximal joints has not been explored. Our purpose was to analyse VCV in adults with and without CAI during gait. Four joint-coupling pairs were analysed: knee sagittal-ankle sagittal, knee sagittal-ankle frontal, hip frontal-ankle sagittal and hip frontal-ankle frontal. Twenty-seven adults participated (CAI:n = 13, Control:n = 14). Lower extremity kinematics were collected during walking (4.83 km/h) and jogging (9.66 km/h). Vector-coding was used to assess the stride-to-stride variability of four coupling pairs. During walking, CAI patients exhibited higher VCV than healthy controls for knee sagittal-ankle frontal in latter parts of stance thru mid-swing. When jogging, CAI patients demonstrated lower VCV with specific differences occurring across various intervals of gait. The increased knee sagittal-ankle frontal VCV in CAI patients during walking may indicate an adaptation to deal with the previously identified decrease in variability in transverse plane shank and frontal plane rearfoot coupling during walking; while the decreased ankle-knee and ankle-hip VCV identified in CAI patients during jogging may represent a more rigid, less adaptable sensorimotor system ambulating at a faster speed.
Huong, Bui Thi Mai; Tuyen, Le Danh; Tuan, Do Huu; Brimer, Leon; Dalsgaard, Anders
2016-12-01
Aflatoxins, fumonisins and ochratoxin A that contaminate various agricultural commodities are considered of significant toxicity and potent human carcinogens. This study took a total dietary study approach and estimated the dietary exposure of these mycotoxins for adults living in Lao Cai province, Vietnam. A total of 42 composite food samples representing 1134 individual food samples were prepared according to normal household practices and analysed for the three mycotoxins. Results showed that the dietary exposure to aflatoxin B1 (39.4 ng/kg bw/day) and ochratoxin A (18.7 ng/kg bw/day) were much higher than recommended provisional tolerable daily intake (PTDI) values mainly due to contaminated cereals and meat. The exposure to total fumonisins (1400 ng/kg bw/day) was typically lower than the PTDI value (2000 ng/kg bw/day). The estimated risk of liver cancer associated with exposure to aflatoxin B1 was 2.7 cases/100,000 person/year. Margin of exposure (MOE) of renal cancer linked to ochratoxin A and liver cancer associated with fumonisins were 1124 and 1954, respectively indicating risk levels of public health concern. Further studies are needed to evaluate the efficiency of technical solutions which could reduce mycotoxin contamination as well as to determine the health effects of the co-exposure to different types of mycotoxins. Copyright © 2016 Elsevier Ltd. All rights reserved.
NASA Astrophysics Data System (ADS)
Kim, Seonguk; Min, Kyoungdoug
2008-08-01
The CAI (controlled auto ignition) engine ignites fuel and air mixture by trapping high temperature burnt gas using a negative valve overlap. Due to auto ignition in CAI combustion, efficiency improvements and low level NOx emission can be obtained. Meanwhile, the CAI combustion regime is restricted and control parameters are limited. The start of combustion data in the compressed ignition engine are most critical for controlling the overall combustion. In this research, the engine block vibration signal is transformed by the Meyer wavelet to analyze CAI combustion more easily and accurately. Signal acquisition of the engine block vibration is a more suitable method for practical use than measurement of in-cylinder pressure. A new method for detecting combustion start in CAI engines through wavelet transformation of the engine block vibration signal was developed and results indicate that it is accurate enough to analyze the start of combustion. Experimental results show that wavelet transformation of engine block vibration can track the start of combustion in each cycle. From this newly developed method, the start of combustion data in CAI engines can be detected more easily and used as input data for controlling CAI combustion.
Wang, Kai; Zhang, Gaoke; Li, Jun; Li, Yuan; Wu, Xiaoyong
2017-12-20
Constructing 0D/2D Z-scheme photocatalysts is a great promising path to improve photocatalytic activity by efficiently enhancing charge separation. Herein, we fabricated a visible-light-responsive Bi 3 TaO 7 quantum dots (QDs)/g-C 3 N 4 nanosheets (NSs) 0D/2D Z-scheme composite via a facile ultrasound method, and Bi 3 TaO 7 QDs could be interspersed on the surface of g-C 3 N 4 NSs uniformly. Furthermore, the strong interaction between Bi 3 TaO 7 QDs and g-C 3 N 4 NSs disturbed the CN heterocycles by forming C═O bonds between C atoms of the N-(C) 3 group and O atoms of the Ta-O bond. The optimum composite with 20 wt % g-C 3 N 4 NSs showed the superior photocatalytic activity for degradation of ciprofloxacin (CIP) over the composites prepared by mechanical mixing and solid-state methods, the photocatalytic efficiency of which were 4 and 12.2 times higher than those of bare Bi 3 TaO 7 and g-C 3 N 4 . Photoluminescence (PL), time-resolved transient PL decay spectra, and photocurrent together verify that the photogenerated hole-electron pairs in this 0D/2D Z-scheme composite have been effectively separated. The enhanced photocatalytic activity of as-synthesized photocatalysts could be attributed to the synergistic effect of efficient Z-scheme charge separation, highly dispersed 0D Bi 3 TaO 7 nanocrystals, coordinating sites of 2D g-C 3 N 4 NSs and the strong coupling between them. This study might pave the way toward designing novel visible-light-induced 0D/2D photocatalyst systems for highly efficient degradation of antibiotics.
, catalysis, and biodiesel Education Ph.D., Bio-Systems Engineering, Washington State University, 2008-2013 Using Acidic Catalyst Generated from Pyrolysis-Derived Bio-Char," Energy Conversion Management
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kim, D.-W.; Protopapas, P.; Alcock, C.
2010-02-15
We analyzed data accumulated during 2005 and 2006 by the Taiwan-American Occultation Survey (TAOS) in order to detect short-period variable stars (periods of {approx}<1 hr) such as {delta} Scuti. TAOS is designed for the detection of stellar occultation by small-size Kuiper Belt Objects and is operating four 50 cm telescopes at an effective cadence of 5 Hz. The four telescopes simultaneously monitor the same patch of the sky in order to reduce false positives. To detect short-period variables, we used the fast Fourier transform algorithm (FFT) in as much as the data points in TAOS light curves are evenly spaced.more » Using FFT, we found 41 short-period variables with amplitudes smaller than a few hundredths of a magnitude and periods of about an hour, which suggest that they are low-amplitude {delta} Scuti stars. The light curves of TAOS {delta} Scuti stars are accessible online at the Time Series Center Web site (http://timemachine.iic.harvard.edu)« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Mondal, S.; Lin, C. C.; Chen, W. P.
2010-05-15
The Taiwanese-American Occultation Survey (TAOS) project has collected more than a billion photometric measurements since 2005 January. These sky survey data-covering timescales from a fraction of a second to a few hundred days-are a useful source to study stellar variability. A total of 167 star fields, mostly along the ecliptic plane, have been selected for photometric monitoring with the TAOS telescopes. This paper presents our initial analysis of a search for periodic variable stars from the time-series TAOS data on one particular TAOS field, No. 151 (R.A. = 17{sup h}30{sup m}6.{sup s}7, decl. = 27{sup 0}17'30'', J2000), which had beenmore » observed over 47 epochs in 2005. A total of 81 candidate variables are identified in the 3 deg{sup 2} field, with magnitudes in the range 8 < R < 16. On the basis of the periodicity and shape of the light curves, 29 variables, 15 of which were previously unknown, are classified as RR Lyrae, Cepheid, {delta} Scuti, SX Phonencis, semi-regular, and eclipsing binaries.« less
Propagation properties of the chirped Airy beams through the gradient-index medium
NASA Astrophysics Data System (ADS)
Feng, Liyan; Zhang, Jianbin; Pang, Zihao; Wang, Linyi; Zhong, Tianfen; Yang, Xiangbo; Deng, Dongmei
2017-11-01
Through analytical derivation and numerical analysis, the propagation properties of the chirped Airy(CAi) beams in the gradient-index medium are investigated. The intensity and the phase distributions, the propagation trajectory and the Poynting vector of the CAi beams are demonstrated to investigate the propagation properties. Owing to the special and symmetrical refractive index profile of the gradient-index medium, the CAi beams propagate periodically. The effects of the distribution factor and the chirped parameter on the propagation of the CAi beams are analyzed. As the increasing of the distribution factor, the intensity distribution of the CAi beams is more scattering. However, with the chirped parameter increasing, the focusing property of the CAi beams strengthens. The variation of the chirped parameter can change the position of the peak intensity maximum, but it cannot alter the period of the peak intensity. The variations of the initial phase and the energy of the beams in the transverse plane expedite accordingly.
Schuck, Sabrina E B; Emmerson, Natasha A; Fine, Aubrey H; Lakes, Kimberley D
2015-02-01
The objective of this study was to provide preliminary findings from an ongoing randomized clinical trial using a canine-assisted intervention (CAI) for 24 children with ADHD. Project Positive Assertive Cooperative Kids (P.A.C.K.) was designed to study a 12-week cognitive-behavioral intervention delivered with or without CAI. Children were randomly assigned to group therapy with or without CAI. Parents of children in both groups simultaneously participated in weekly parent group therapy sessions. Across both treatment groups, parents reported improvements in children's social skills, prosocial behaviors, and problematic behaviors. In both groups, the severity of ADHD symptoms declined during the course of treatment; however, children who received the CAI model exhibited greater reductions in the severity of ADHD symptoms than did children who received cognitive-behavioral therapy without CAI. Results suggest that CAI offers a novel therapeutic strategy that may enhance cognitive-behavioral interventions for children with ADHD. © 2013 SAGE Publications.
Top ten reasons the World Wide Web may fail to change medical education.
Friedman, R B
1996-09-01
The Internet's World Wide Web (WWW) offers educators a unique opportunity to introduce computer-assisted instructional (CAI) programs into the medical school curriculum. With the WWW, CAI programs developed at one medical school could be successfully used at other institutions without concern about hardware or software compatibility; further, programs could be maintained and regularly updated at a single central location, could be distributed rapidly, would be technology-independent, and would be presented in the same format on all computers. However, while the WWW holds promise for CAI, the author discusses ten reasons that educators' efforts to fulfill the Web's promise may fail, including the following: CAI is generally not fully integrated into the medical school curriculum; students are not tested on material taught using CAI; and CAI programs tend to be poorly designed. The author argues that medical educators must overcome these obstacles if they are to make truly effective use of the WWW in the classroom.
ERIC Educational Resources Information Center
Lindsay, Robert E.
1970-01-01
Describes a novel instructional method for physics involving the use of a computer assisted instruction system equipped with cathode-ray-tube terminals, light pen, and keyboard input. Discusses exercises with regard to content, mediation, scoring and control. Several examples of exercises are given along with results from student evaluation. (LC)
Thompson, Ren A.; Turner, Kenzie J.; Shroba, Ralph R.; Cosca, Michael A.; Ruleman, Chester A.; Lee, John P.; Brandt, Theodore R.
2014-01-01
The Ute Mountain 7.5' quadrangle is located in the south-central part of the San Luis Basin of northern New Mexico, in the Rio Grande del Norte National Monument, and contains deposits that record volcanic, tectonic, and associated alluvial and colluvial processes over the past four million years. Ute Mountain has the distinction of being one of the largest intermediate composition eruptive centers of the Taos Plateau, a largely volcanic tableland occupying the southern portion of the San Luis Basin. Ute Mountain rises to an elevation in excess of 3,000 m, nearly 700 m above the basaltic plateau at its base, and is characterized by three distinct phases of Pliocene eruptive activity recorded in the stratigraphy exposed on the flanks of the mountain and in the Rio Grande gorge. Unconformably overlain by largely flat-lying lava flows of Servilleta Basalt, the area surrounding Ute Mountain records a westward thickening of basin-fill volcanic deposits interstratified in the subsurface with Pliocene basin-fill sedimentary deposits derived from older Tertiary and Precambrian sources to the east. Superimposed on this volcanic stratigraphy are alluvial and colluvial deposits derived from the flanks of Ute Mountain and more distally-derived alluvium from the uplifted Sangre de Cristo Mountains to the east, that record a complex temporal and stratigraphic succession of Quaternary basin deposition and erosion. Pliocene and younger basin deposition was accommodated along predominantly north-trending fault-bounded grabens. These poorly exposed fault scarps cutting lava flows of Ute Mountain volcano. The Servilleta Basalt and younger surficial deposits record largely down-to-east basinward displacement. Faults are identified with varying confidence levels in the map area. Recognizing and mapping faults developed near the surface in young, brittle volcanic rocks is difficult because: (1) they tend to form fractured zones tens of meters wide rather than discrete fault planes, (2
Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity
Ponto, K A; Schuppan, D; Zwiener, I; Binder, H; Mirshahi, A; Diana, T; Pitz, S; Pfeiffer, N; Kahaly, G J
2014-01-01
Common autoimmune disorders tend to co-exist in the same subjects and cluster in families. The objective of this study was to determine the prevalence of autoimmune co-morbidity in patients with autoimmune thyroid disease (AITD) with and without thyroid-associated orbitopathy (TAO). This was a cross-sectional study conducted at an academic tertiary referral centre. Of 1310 patients with AITD [n = 777 or 59% with Graves' disease (GD) and n = 533, 41% with Hashimoto's thyroiditis (HT)] followed at a specialized joint thyroid–eye out-patient clinic, 176 (13·4%) had an adult type of the autoimmune polyglandular syndrome, 129 (9·8%) type 1 diabetes, 111 (8·5%) coeliac disease, 60 (4·6%) type A autoimmune gastritis, 57 (4·4%) vitiligo and 25 (1·9%) Addison's disease. Coeliac disease and autoimmune gastritis were associated positively with GD [odds ratio (OR) = 2·18; P = 0·002 and OR = 6·52; P < 0·001], whereas type 1 diabetes, Addison's disease, autoimmune primary hypogonadism, alopecia areata, rheumatoid arthritis and Sjögren's syndrome were ‘protective’ for GD and thus linked to HT, OR = 0·49 (P < 0·001), 0·06 (P < 0·001), 0·25 (P < 0·001), 0·50 (P = 0·090) and 0·32 (P = 0·003), respectively. Of 610 (46·6%) AITD patients with TAO, 584 (95·7%) and 26 (4·3%) had GD and HT, respectively (P < 0·001). TAO was most prevalent in GD patients with coeliac disease (94%, OR = 1·87, P < 0·001). Multivariate analysis showed high OR for coeliac disease and autoimmune gastritis (3·4 and 4·03, both P < 0·001) pertaining to the association with TAO while type 1 diabetes, Addison's disease and alopecia areata were protective for TAO. In patients with TAO, coeliac disease is the most prevalent co-morbid autoimmune condition and rates are increased compared to GD patients without TAO. PMID:24903731
Intelligent tutoring systems research in the training systems division: Space applications
NASA Technical Reports Server (NTRS)
Regian, J. Wesley
1988-01-01
Computer-Aided Instruction (CAI) is a mature technology used to teach students in a wide variety of domains. The introduction of Artificial Intelligence (AI) technology of the field of CAI has prompted research and development efforts in an area known as Intelligent Computer-Aided Instruction (ICAI). In some cases, ICAI has been touted as a revolutionary alternative to traditional CAI. With the advent of powerful, inexpensive school computers, ICAI is emerging as a potential rival to CAI. In contrast to this, one may conceive of Computer-Based Training (CBT) systems as lying along a continuum which runs from CAI to ICAI. Although the key difference between the two is intelligence, there is not commonly accepted definition of what constitutes an intelligent instructional system.
Wilson, Patrick A.; Kahana, Shoshana Y.; Fernandez, Maria Isabel; Harper, Gary W.; Mayer, Kenneth; Wilson, Craig M.; Hightow-Weidman, Lisa B.
2016-01-01
Importance Human immunodeficiency virus (HIV) diagnoses continue to increase among young men who have sex with men (YMSM). Many YMSM living with HIV engage in sexual risk behaviors, and those who have a detectable viral load can transmit HIV to sex partners. Understanding factors that are related to sexual risk taking among virologically detectable (VL+) YMSM can inform prevention and treatment efforts. Objectives To describe differences between virologically suppressed (VL−) and VL+ YMSM living with HIV and to identify correlates of condomless anal intercourse (CAI) and serodiscordant CAI among VL+ YMSM. Design, Setting, and Participants In this cross-sectional survey conducted from December 1, 2009, through June 30, 2012, we studied 991 HIV-infected YMSM 15 to 26 years of age at 20 adolescent HIV clinics in the United States. Data analysis was conducted December 1, 2013, through July 31, 2015. Main Outcomes and Measures Demographic, behavioral, and psychosocial assessments obtained using audio computer-assisted self-interviews. Viral load information was obtained via blood draw or medical record abstraction. Results Of the 991 participants, 688 (69.4%) were VL+ and 458 (46.2%) reported CAI, with 310 (31.3%) reporting serodiscordant CAI in the past 3 months. The VL+ YMSM were more likely than the VL− YMSM to report CAI (detectable, 266 [54.7%]; suppressed, 91 [44.4%]; P = .01) and serodiscordant CAI (detectable, 187 [34.9%]; suppressed, 57 [25.0%]; P < .01). Multivariable analyses indicated that among VL+ YMSM, those reporting problematic substance use were more likely to report CAI (adjusted odds ratio [AOR], 1.46; 95% CI, 1.02-2.10) and serodiscordant CAI (AOR, 1.45; 95% CI, 1.06-1.99). Black VL+ YMSM were less likely to report CAI (AOR, 0.63; 95% CI, 0.44-0.90) or serodiscordant CAI (AOR, 0.66; 95% CI, 0.46-0.94) compared with other VL+ YMSM. In addition, VL+ YMSM who disclosed their HIV status to sex partners were more likely to report CAI compared with
Chronic Ankle Instability and Neural Excitability of the Lower Extremity.
McLeod, Michelle M; Gribble, Phillip A; Pietrosimone, Brian G
2015-08-01
Neuromuscular dysfunction of the leg and thigh musculature, including decreased strength and postural control, is common in patients with chronic ankle instability (CAI). Understanding how CAI affects specific neural pathways may provide valuable information for targeted therapies. To investigate differences in spinal reflexive and corticospinal excitability of the fibularis longus and vastus medialis between limbs in patients with unilateral CAI and between CAI patients and participants serving as healthy controls. Case-control study. Research laboratory. A total of 56 participants volunteered, and complete data for 21 CAI patients (9 men, 12 women; age = 20.81 ± 1.63 years, height = 171.57 ± 11.44 cm, mass = 68.84 ± 11.93 kg) and 24 healthy participants serving as controls (7 men, 17 women; age = 22.54 ± 2.92 years, height = 172.35 ± 10.85 cm, mass = 69.15 ± 12.30 kg) were included in the final analyses. Control participants were matched to CAI patients on sex, age, and limb dominance. We assigned "involved" limbs, which corresponded with the involved limbs of the CAI patients, to control participants. Spinal reflexive excitability was assessed via the Hoffmann reflex and normalized to a maximal muscle response. Corticospinal excitability was assessed using transcranial magnetic stimulation. Active motor threshold (AMT) was defined as the lowest transcranial magnetic stimulation intensity required to elicit motor-evoked potentials equal to or greater than 100 μV in 5 of 10 consecutive stimuli. We obtained motor-evoked potentials (MEPs) at percentages ranging from 100% to 140% of AMT. Fibularis longus MEP amplitudes were greater in control participants than in CAI patients bilaterally at 100% AMT (control involved limb: 0.023 ± 0.031; CAI involved limb: 0.014 ± 0.008; control uninvolved limb: 0.021 ± 0.022; CAI uninvolved limb: 0.015 ± 0.007; F1,41 = 4.551, P = .04) and 105% AMT (control involved limb: 0.029 ± 0.026; CAI involved limb: 0.021 ± 0
Peroneal electromechanical delay and fatigue in patients with chronic ankle instability.
Flevas, Dimitrios A; Bernard, Manfred; Ristanis, Stavros; Moraiti, Constantina; Georgoulis, Anastasios D; Pappas, Evangelos
2017-06-01
The purpose of this study was to investigate the effect of chronic ankle instability (CAI) on electromechanical delay times (EMD) before and after fatigue. Understanding the mechanisms that contribute to CAI is essential for the development of effective rehabilitation programmes. It was hypothesized that patients with CAI will demonstrate prolonged EMD times compared to healthy subjects and that fatigue will cause greater increases in EMD times in the CAI group. Twenty-one male volunteers participated in the study providing data on 16 ankles with CAI and 26 with no history of ankle injury. EMD was measured on an isokinetic dynamometer. Measurements were taken with the ankle in neutral (0°) and at 30° of inversion. All subjects followed an isokinetic fatigue protocol until eversion torque fell below 50 % of initial torque for three consecutive repetitions. A 2 × 2 × 2 ANOVA was used to calculate the effect of ankle status (CAI vs. healthy), fatigue, angle (0° vs. 30°) and their interactions on EMD. Fatigue caused a significant increase on EMD [non-fatigued: 122(29)ms vs. fatigue 155(54)ms; p < 0.001]. EMD times were shorter at 30° of inversion compared to neutral [neutral: 145(39)ms vs. 30° of inversion: 132(40)ms, p = 0.015]. An interaction effect for ankle status and angle was found (p = 0.026) with CAI ankles demonstrating longer EMD [CAI: 156(45)ms vs. healthy: 133(40)ms] in neutral but not at 30° of inversion [CAI: 133(46)ms vs. 132(33)ms]. Patients with CAI had longer EMD times in neutral, but not when the ankle was placed in inversion. This suggests that rehabilitation programmes may be more effective when retraining occurs with the ankle in neutral position. It is likely that low EMD times prevent ankle acceleration at the beginning of the mechanism of injury, but they are less important when the ankle has already inverted at 30°. Both CAI and healthy subjects demonstrated longer EMD after fatigue, emphasizing the importance of proper
Drills vs. Games--Any Differences? A Pilot Study.
ERIC Educational Resources Information Center
McMullen, David W.
This study investigated the effect of informational, drill, and game format computer-assisted instruction (CAI) on the achievement, retention, and attitude toward instruction of sixth-grade science students (N=37). An informational CAI lesson on Halley's Comet was administered to three randomly selected groups of sixth-grade students. A CAI drill…
Systematic review of chronic ankle instability in children
2014-01-01
Background Chronic ankle instability (CAI) is a disabling condition often encountered after ankle injury. Three main components of CAI exist; perceived instability; mechanical instability (increased ankle ligament laxity); and recurrent sprain. Literature evaluating CAI has been heavily focused on adults, with little attention to CAI in children. Hence, the objective of this study was to systematically review the prevalence of CAI in children. Methods Studies were retrieved from major databases from earliest records to March 2013. References from identified articles were also examined. Studies involving participants with CAI, classified by authors as children, were considered for inclusion. Papers investigating traumatic instability or instability arising from fractures were excluded. Two independent examiners undertook all stages of screening, data extraction and methodological quality assessments. Screening discrepancies were resolved by reaching consensus. Results Following the removal of duplicates, 14,263 papers were screened for eligibility against inclusion and exclusion criteria. Nine full papers were included in the review. Symptoms of CAI evaluated included perceived and mechanical ankle instability along with recurrent ankle sprain. In children with a history of ankle sprain, perceived instability was reported in 23-71% whilst mechanical instability was found in 18-47% of children. A history of recurrent ankle sprain was found in 22% of children. Conclusion Due to the long-lasting impacts of CAI, future research into the measurement and incidence of ankle instability in children is recommended. PMID:24641786
New directions in e-learning research in health professions education: Report of two symposia.
Triola, Marc M; Huwendiek, Sören; Levinson, Anthony J; Cook, David A
2012-01-01
The use of Computer Assisted Instruction (CAI) is rising across health professions education. Research to date is of limited use in guiding the implementation and selection of CAI innovations. In the context of two symposia, systemic reviews were discussed that evaluate literature in Internet-based learning, Virtual Patients, and animations. Each session included a debate with the goal of reaching consensus on best current practices and future research. Thematic analysis of the discussions was performed to arrange the questions by theme, eliminate redundancy, and craft them into a cohesive narrative. The question analysis revealed that there are clear advantages to the use of CAI, and that established educational theories should certainly inform the future development and selection of CAI tools. Schools adopting CAI need to carefully consider the benefits, cost, available resources, and capacity for teachers and learners to accept change in their practice of education. Potential areas for future research should focus on the effectiveness of CAI instructional features, integration of e-learning into existing curricula and with other modalities like simulation, and the use of CAI in assessment of higher-level outcomes. There are numerous opportunities for future research and it will be important to achieve consensus on important themes.
1980-03-01
authoring system which would provide a basis for the cost effective production of computer-assisted irstruction (CAI) materials, It addresses the definition...RESULTS- - ------------------- 58 CAI Materials Development Times - - - 5J CAI Module Instructional Effectiveness -------- -- 59 First-Pass Module...CONCLUSIONS AND RECOMMENDATIONS ------ --- -- -- 70 Effectiveness of the Authoring System and Suggestions for Further Development - ----- --- -- --- 70
NASA Astrophysics Data System (ADS)
Latham, Patricia S.
The purpose of this quantitative experimental study was to test the impact of three learning interventions on student learning and satisfaction when the interventions were embedded in the instructional design of case-based, Computer-Assisted Instruction (CAI) modules for learning liver pathology in an in-class, self-study, laboratory exercise during a Year-2 medical school Pathology course. The hypothesis was that inclusion of the learning interventions would enhance student satisfaction in using the CAI and improve subsequent CAI-directed exam performance. Three learning interventions were studied, including the use of microscopic virtual slides instead of only static images, the use of interactive image annotations instead of only still annotations, and the use of guiding questions before presenting new information. Students were randomly assigned to with one of eight CAI learning modules configured to control for each of the three learning interventions. Effectiveness of the CAI for student learning was assessed by student performance on questions included in subsequent CAI-directed exams in a pretest and on posttests immediately after the lab exercise, at two weeks and two months. Student satisfaction and perceived learning was assessed by a student survey. Results showed that the learning interventions did not improve subsequent student exam performance, although satisfaction and perceived learning with use of the CAI learning modules was enhanced. Student class rank was evaluated to determine if the learning interventions might have a differential effect based on class rank, but there were no significant differences. Class rank at the time of the lab exercise was itself the strongest predictor of exam performance. The findings suggest that the addition of virtual slides, interactive annotations and guiding questions as learning interventions in self-study, case-based CAI for learning liver pathology in a medical class room setting are not likely to increase
NASA Technical Reports Server (NTRS)
Cuzzi, Jeffrey N.; Davis, Sanford S.; Dobrovolskis, Anthony R.
2003-01-01
Ca-A1 rich refractory mineral inclusions (CAIs) found at 1-6% mass fraction in primitive chondrites appear to be 1-3 million years older than the dominant (chondrule) components which were accreted into the same parent bodies. A prevalent concern is that it is difficult to retain CAIs for this long against gas-drag-induced radial drift into the sun. We reassess the situation in terms of a hot inner (turbulent) nebula context for CAI formation, using analytical models of nebula evolution and particle diffusion. We show that outward radial diffusion in a weakly turbulent nebula can overwhelm inward drift, and prevent significant numbers of CAI-size particles from being lost into the sun for times on the order of 10(exp 6) years. CAIs can form early, when the inner nebula was hot, and persist in sufficient abundance to be incorporated into primitive planetesimals at a much later time. Small (less than or approximately 0.1 mm diameter) CAIs persist for longer times than large (greater than or approximately 5mm diameter ones. To obtain a quantitative match to the observed volume fractions of CAIs in chondrites, another process must be allowed for: a substantial enhancement of the inner hot nebula in silicate-forming material, which we suggest was caused by rapid inward drift of meter-sized objects. This early in nebula history, the drifting rubble would have a carbon content probably an order of magnitude larger than even the most primitive (CI) carbonaceous chondrites. Abundant carbon in the evaporating material would help keep the nebula oxygen fugacity low, plausibly solar; as inferred for the formation environment of CAIs. The associated production of a larger than canonical amount of CO2 might also play a role in mass-independent fractionation of oxygen isotopes, leaving the gas rich in O-16 as inferred from CAIs and other high temperature condensates.
A Concept For a Primary Author's Language (PAL-X)
ERIC Educational Resources Information Center
Ripota, Peter
A Primary Author's Language (PAL-X) has been developed to serve as a documentation language for computer-assisted instructional (CAI) programs. Its development was necessary to permit the dissemination of CAI given the facts that: 1)existing CAI programs were written in over 60 languages; 2)the system for COURSEWRITER II, the most commonly used…
Computer-Assisted Instruction In Dental Diagnosis; A Systematic Product Development.
ERIC Educational Resources Information Center
Barber, Thomas K.; Sokolow, Sonya
A developmental project created and field tested a computer-assisted instructional (CAI) unit in dental diagnosis. The main objectives were to determine 1) if, after having received CAI, the dental student could determine whether a patient had a clinical need for space management and 2) if the dental student's attitude toward CAI and space…
Markets and Models for Large-Scale Courseware Development.
ERIC Educational Resources Information Center
Bunderson, C. Victor
Computer-assisted instruction (CAI) is not making an important, visible impact on the educational system of this country. Though its instructional value has been proven time after time, the high cost of the hardware and the lack of quality courseware is preventing CAI from becoming a market success. In order for CAI to reach its market potential…
Microcomputer Based Computer-Assisted Learning System: CASTLE.
ERIC Educational Resources Information Center
Garraway, R. W. T.
The purpose of this study was to investigate the extent to which a sophisticated computer assisted instruction (CAI) system could be implemented on the type of microcomputer system currently found in the schools. A method was devised for comparing CAI languages and was used to rank five common CAI languages. The highest ranked language, NATAL,…
Hamann, Stephan; Stevens, Jennifer; Vick, Janice Hassett; Bryk, Kristina; Quigley, Charmian A; Berenbaum, Sheri A; Wallen, Kim
2014-11-01
Androgens, estrogens, and sex chromosomes are the major influences guiding sex differences in brain development, yet their relative roles and importance remain unclear. Individuals with complete androgen insensitivity syndrome (CAIS) offer a unique opportunity to address these issues. Although women with CAIS have a Y chromosome, testes, and produce male-typical levels of androgens, they lack functional androgen receptors preventing responding to their androgens. Thus, they develop a female physical phenotype, are reared as girls, and develop into women. Because sexually differentiated brain development in primates is determined primarily by androgens, but may be affected by sex chromosome complement, it is currently unknown whether brain structure and function in women with CAIS is more like that of women or men. In the first functional neuroimaging study of (46,XY) women with CAIS, typical (46,XX) women, and typical (46, XY) men, we found that men showed greater amygdala activation to sexual images than did either typical women or women with CAIS. Typical women and women with CAIS had highly similar patterns of brain activation, indicating that a Y chromosome is insufficient for male-typical human brain responses. Because women with CAIS produce male-typical or elevated levels of testosterone which is aromatized to estradiol these results rule out aromatization of testosterone to estradiol as a determinate of sex differences in patterns of brain activation to sexual images. We cannot, however, rule out an effect of social experience on the brain responses of women with CAIS as all were raised as girls. Copyright © 2014 Elsevier Inc. All rights reserved.
Evidence for Widespread 26Al in the Solar Nebula and Constraints for Nebula Time Scales
Russell; Srinivasan; Huss; Wasserburg; MacPherson
1996-08-09
A search was made for 26Mg (26Mg*) from the decay of 26Al (half-life = 0.73 million years) in Al-rich objects from unequilibrated ordinary chondrites. Two Ca-Al-rich inclusions (CAIs) and two Al-rich chondrules (not CAIs) were found that contained 26Al when they formed. Internal isochrons for the CAIs yielded an initial 26Al/27Al ratio [(26Al/27Al)0] of 5 x 10(-5), indistinguishable from most CAIs in carbonaceous chondrites. This result shows that CAIs with this level of 26Al are present throughout the classes of chondrites and strengthens the notion that 26Al was widespread in the early solar system. The two Al-rich chondrules have lower 26Mg*, corresponding to a (26Al/27Al)0 ratio of approximately 9 x 10(-6). Five other Al-rich chondrules contain no resolvable 26Mg*. If chondrules and CAIs formed from an isotopically homogeneous reservoir, then the chondrules with 26Al must have formed or been last altered approximately2 million years after CAIs formed; the 26Mg*-free chondrules formed >1 to 3 million years later still. Because 26Mg*-containing and 26Mg*-free chondrules are both found in Chainpur, which was not heated to more than approximately400°C, it follows that parent body metamorphism cannot explain the absence of 26Mg* in some of these chondrules. Rather, its absence indicates that the lifetime of the solar nebula over which CAIs and chondrules formed extended over approximately5 million years.
Lieberman, Gillian; Abramson, Richard; Volkan, Kevin; McArdle, Patricia J
2002-01-01
This study compared the educational effectiveness of an interactive tutorial with that of interactive computer-assisted instruction (CAI) and determined the effects of personal preference, learning style, and level of training. Fifty-four medical students and four radiology residents were prospectively, randomly assigned to receive instruction from different sections of an interactive tutorial and an interactive CAI module. Participants took tests of factual knowledge at the beginning and end of the instruction and a test of visual diagnosis at the end. They completed questionnaires to evaluate their preferred learning styles objectively and to elicit their subjective attitudes toward the two formats. Mean test scores of the tutorial and CAI groups were compared by means of analysis of covariance and two-tailed repeated-measures F test. Both the tutorial and CAI groups demonstrated significant improvement in posttest scores (P < .01 and P < .01, respectively) with the tutorial group's mean posttest score marginally but significantly higher (32.84 vs 28.13, P < .001). There were no significant interaction effects with participants' year of training (P = .845), objectively evaluated preferred learning style (P = .312), subjectively elicited attitude toward learning with CAI (P = .703), or visual diagnosis score (tutorial, 7.61; CD-ROM, 7.75; P = .79). Interactive tutorial and optimal CAI are both effective instructional formats. The tutorial was marginally but significantly more effective at teaching factual knowledge, an effect unrelated to students' year of training, learning style, or stated enjoyment of CAI. The superiority of the tutorial is expected to increase when it is compared with commercially expedient CAI modules.
Self-Rectifying Effect in Resistive Switching Memory Using Amorphous InGaZnO
NASA Astrophysics Data System (ADS)
Lee, Jin-Woo; Kwon, Hyeon-Min; Kim, Myeong-Ho; Lee, Seung-Ryul; Kim, Young-Bae; Choi, Duck-Kyun
2014-05-01
Resistance random access memory (ReRAM) has received attention as next-generation memory because of its excellent operating properties and high density integration capability as a crossbar array. However, the application of the existing ReRAM as a crossbar array may lead to crosstalk between adjacent cells due to its symmetric I- V characteristics. In this study, the self-rectifying effect of contact between amorphous In-Ga-Zn-O (a-IGZO) and TaO x was examined in a Pt/a-IGZO/TaO x /Al2O3/W structure. The experimental results show not only self-rectifying behavior but also forming-free characteristics. During the deposition of a-IGZO on the TaO x , an oxygen-rich TaO x interfacial layer was formed. The rectifying effect was observed regardless of the interface formation and is believed to be associated with Schottky contact formation between a-IGZO and TaO x . The current level remained unchanged despite repeated DC sweep cycles. The low resistance state/high resistance state ratio was about 101 at a read voltage of -0.5 V, and the rectifying ratio was about 103 at ±2 V.
NASA Technical Reports Server (NTRS)
Simon, J. I.; Matzel, J. E. P.; Simon, S. B.; Weber, P. K.; Grossman, L.; Ross, D. K.; Hutcheon, I. D.
2013-01-01
Large systematic variations in O-isotopic compositions found within individual mineral layers of rims surrounding Ca-, Al-rich inclusions (CAIs) and at the margins of some CAIs imply formation from distinct environments [e.g., 1-3]. The O-isotope compositions of many CAIs preserve a record of the Solar nebula gas believed to initially be O-16-rich (delta O-17 less than or equal to -25%0) [4-5]. Data from a recent study of the compact Type A Allende CAI, A37, preserve a diffusion profile in the outermost 70 micrometers of the inclusion and show greater than 25%0 variations in delta O-17 within its 100 micrometer-thick Wark-Lovering rim (WL-rim) [3]. This and comparable heterogeneity measured in several other CAIs have been explained by isotopic mixing between the O-16-rich Solar reservoir and a second O-16-poor reservoir (probably nebular gas) with a planetary-like isotopic composition, e.g., [1,2,3,6]. However, there is mineralogical and isotopic evidence from the interiors of CAIs, in particular those from Allende, for parent body alteration. At issue is how to distinguish the record of secondary reprocessing in the nebula from that which occurred on the parent body. We have undertaken the task to study a range of CAI types with varying mineralogies, in part, to address this problem.
Static Postural Stability in Chronic Ankle Instability, An Ankle Sprain and Healthy Ankles.
Kwon, Yong Ung
2018-05-18
To identify the single leg balance (SLB) test that discriminates among healthy, coper, and chronic ankle instability (CAI) groups and to determine effects of ankle muscles on the balance error scoring system (BESS) among the three populations. 60 subjects (20 per group) performed the SLB test with eyes open (EO) and eyes closed (EC). Normalized mean amplitude (NMA) of the tibia anterior (TA), fibularis longus (FL), and medial gastrocnemius (MG) muscles and BESS were measured while performing the SLB test. The coper group had a lower error score than the CAI group in the EC. NMA was greater in the CAI group compared to in the healthy and coper groups regardless of muscle type. NMA of the TA was less than the PL and MG regardless of the group in the EO. The CAI group demonstrated greater NMAs of the PL and MG than the healthy and coper groups in the EC. The CAI group demonstrated greater NMA of the PL and MG by compensating their ankle muscles in the EO and EC. BESS suggests that the coper group may have coping mechanisms to stabilize static postural control compared to the CAI group. The EC may be better to detect static postural instability in the CAI or coper group. © Georg Thieme Verlag KG Stuttgart · New York.
Neural Excitability and Joint Laxity in Chronic Ankle Instability, Coper, and Control Groups.
Bowker, Samantha; Terada, Masafumi; Thomas, Abbey C; Pietrosimone, Brian G; Hiller, Claire E; Gribble, Phillip A
2016-04-01
Neuromuscular and mechanical deficiencies are commonly studied in participants with chronic ankle instability (CAI). Few investigators have attempted to comprehensively consider sensorimotor and mechanical differences among people with CAI, copers who did not present with prolonged dysfunctions after an initial ankle sprain, and a healthy control group. To determine if differences exist in spinal reflex excitability and ankle laxity among participants with CAI, copers, and healthy controls. Case-control study. Research laboratory. Thirty-seven participants with CAI, 30 participants categorized as copers, and 26 healthy control participants. We assessed spinal reflex excitability of the soleus using the Hoffmann reflex protocol. Participants' ankle laxity was measured with an instrumented ankle arthrometer. The maximum Hoffmann reflex : maximal muscle response ratio was calculated. Ankle laxity was measured as the total displacement in the anterior-posterior directions (mm) and total rotation in the inversion and eversion directions (°). Spinal reflex excitability was diminished in participants with CAI compared with copers and control participants (P = .01). No differences were observed among any of the groups for ankle laxity. Changes in the spinal reflex excitability of the soleus that likely affect ankle stability were seen only in the CAI group, yet no mechanical differences were noted across the groups. These findings support the importance of finding effective ways to increase spinal reflex excitability for the purpose of treating neural excitability dysfunction in patients with CAI.
Oxidative stress, microRNAs and cytosolic calcium homeostasis.
Magenta, Alessandra; Dellambra, Elena; Ciarapica, Roberta; Capogrossi, Maurizio C
2016-09-01
Reactive oxygen species increase cytosolic [Ca(2+)], (Cai), and also modulate the expression of some microRNAs (miRNAs), however the link among oxidative stress, miRNAs and Cai is poorly characterized. In this review we have focused on three groups of miRNAs: (a) miRNAs that are modulated both by ROS and Cai: miR-181a and miR-205; (b) miRNAs that are modulated by ROS and have an effect on Cai: miR-1, miR-21, miR-24, miR-25, miR-185 and miR-214; (c) miRNAs that modulate both ROS and Cai: miR-133; miR-145, miR-495, and we have analyzed their effects on cell signaling and cell function. Finally, in the last section we have examined the role of these miRNAs in the skin, under conditions associated with enhanced oxidative stress, i.e. skin aging, the response to ultraviolet light and two important skin diseases, psoriasis and atopic dermatitis. It is apparent that although some experimental evidence is already available on (a) the role of Cai in miRNAs expression and (b) on the ability of some miRNAs to modulate Cai-dependent intracellular signaling, these research lines are still largely unexplored and represent important areas of future studies. Copyright © 2016 Elsevier Ltd. All rights reserved.
The cross-cultural relationships between nurses and Filipino Canadian patients.
Pasco, Alberta Catherine Y; Morse, Janice M; Olson, Joanne K
2004-01-01
To describe culturally embedded values that implicitly guide Filipino Canadian patients' interactions with Canadian nurses and are integral to nurse-patient relationships. A focused ethnography was conducted, with a purposive sample of 23 Filipino-Canadians who received care in Canadian hospitals. Data consisted of interviews, field notes, and diary. When receiving care, patients delineated hindi ibang tao (one of us) and ibang tao (not one of us) and this determined their preference for who performed personal and private tasks or received information. The urgency of the patients' conditions, the intimacy required for most nursing procedures, and short hospitalizations meant that patients often interacted without progressing through the cultural levels of pakikitungo (formality), pakikibagay (adjustability), and pakikisama (acceptance). Rather, the crisis of being hospitalized forced patients to immediately move toward the cultural levels of pakikipagpalagayang-loob (mutual comfort) or pakikiisa (oneness). Patients' willingness to trust and to share their kapwa-oriented worldview in relating with fellow human beings, and their use of their languages of words, gaze, touch, and food, allowed nurses to become hindi ibang tao (one of us). Caregiving roles and establishing relationships also distinguished that hindi ibang tao (one of us) was to bantay (watch over) the patient, whereas ibang tao (not one of us) was expected to alaga (care for) them (i.e., provide professional care). Communicating and caring effectively requires understanding of Filipino Canadians' languages of words, gaze, touch, and food and their levels of interaction. Culturally safe nurse-patient relationships can then develop.
From Red Cliffs to Chosin: The Chinese Way of War
2010-05-01
Thinking, (Honolulu: University of Hawaii Press, 2004), 1. 30 Thomas Cleary, trans., The Essential Tao: An Initiation into the Heart of Taoism Through...oversight methods that enabled fuller use of the land and greater food production, expanded industry and trade, and more effective conscription and...and trans. Princeton: Princeton University Press, 1976. Cleary, Thomas, trans. The Essential Tao: An Initiation into the Heart of Taoism Through
Patient-Reported Outcome Measures in Individuals With Chronic Ankle Instability: A Systematic Review
Houston, Megan N.; Hoch, Johanna M.; Hoch, Matthew C.
2015-01-01
Context A comprehensive systematic literature review of the health-related quality-of-life (HRQOL) differences among individuals with chronic ankle instability (CAI), ankle-sprain copers, and healthy control participants has not been conducted. It could provide a better indication of the self-reported deficits that may be present in individuals with CAI. Objective To systematically summarize the extent to which HRQOL deficits are present in individuals with CAI. Data Sources We searched for articles in the electronic databases of EBSCO Host and PubMed Central using key words chronic, functional, mechanical, coper, instability, sprains, and patient-assessed. We also performed a hand search of reference lists, authors, and patient-reported outcomes (PROs) of the articles screened for inclusion. Study Selection Studies were included if they (1) incorporated a PRO as a participant descriptor or as a study outcome to compare adults with CAI to ankle-sprain copers or healthy controls, (2) were written in English, and (3) were published in peer-reviewed journals. Data Extraction Two authors independently assessed methodologic quality using the modified Downs and Black Index. Articles were filtered into 3 categories based on between-groups comparisons: CAI and copers, CAI and healthy control participants, copers and healthy participants. We calculated Hedges g effect sizes and 95% confidence intervals to examine PRO group differences. Data Synthesis Of the 124 studies assessed for eligibility, 27 were included. A total of 24 articles compared PROs in individuals with CAI and healthy controls, 7 compared individuals with CAI and copers, and 4 compared copers and healthy controls. Quality scores on the modified Downs and Black Index ranged from 52.9% to 88.2%, with 8 high-, 16 moderate-, and 3 low-quality studies. Overall, we observed moderate to strong evidence that individuals with CAI displayed deficits on generic and region-specific PROs compared with
Renewed Search for FUN (Fractionated and Unidentified Nuclear Effects) in Primitive Chondrites
DOE Office of Scientific and Technical Information (OSTI.GOV)
Tollstrup, D L; Wimpenny, J B; Yin, Q -
Ca-Al-rich inclusions (CAIs) found in primitive chondrites record processes and conditions of the earliest solar system as they are the oldest known solid objects formed in the solar system [1,2]. CAIs with fractionation and unidentified nuclear anomalies (FUN CAIs; [3]) are very rare and thusfar found exclusively in CV carbonaceous chondrites (e.g., Allende and Vigarano)[4]. FUN CAIs are characterized by large nucleosynthetic anomalies in several elements (Ca, Ti, Si, Sr, Ba, Nd, and Sm), large mass-dependant isotope fractionation (Mg, Si, and O), and very little initial {sup 26}Al [4,5 and reference therein]. Formation of FUN CAIs by thermal processing ofmore » presolar dust aggregates prior to the injection of {sup 26}Al into the protoplanetary disk has been proposed. More recently [5] proposed that FUN CAIs formed from a protosolar molecular cloud after injection of {sup 26}Al but before {sup 26}Al and {sup 27}Al were completely homogenized. Therefore discovering more FUN CAIs to perform U-Pb and other short-lived chronometric dating will provide key constraints on the age of the solar system, the isotopic composition of the protosolar molecular cloud, the earliest stages of the thermal processing in the solar system and the timing of {sup 26}Al and other short-lived radionuclide injection into the nascent solar system. Most known FUN CAIs were discovered and studied > 30 yr ago, and their isotope ratios determined using thermal ionization mass spectrometry (TIMS). Most of these FUN CAIs were almost or entirely consumed during their respective analyses. [5] recently identified a new FUN CAI (NWA 779 KS-1) based on O and Mg isotope ratios determined by SIMS and MCICPMS, respectively. We have initiated a systematic search for FUN CAIs in primitive chondrites, taking advantage of the large mass-dependant Mg isotope effects known for FUN inclusions with little or no inferred {sup 26}Al. Our strategy is to use newly developed sample cells capable of holding very
2016-08-01
Using Categorical and Object-Based Methods by John W Raby and Huaqing Cai Approved for public release; distribution...by John W Raby and Huaqing Cai Computational and Information Sciences Directorate, ARL Approved for public release...AUTHOR(S) John W Raby and Huaqing Cai 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND
NASA Technical Reports Server (NTRS)
Spradley, L. W.; Dean, W. G.; Karu, Z. S.
1976-01-01
The thermal acoustic oscillations (TAO) data base was expanded by running a large number of tubes over a wide range of parameters known to affect the TAO phenomenon. These parameters include tube length, wall thickness, diameter, material, insertion length and length-to-diameter ratio. Emphasis was placed on getting good boiloff data. A large quantity of data was obtained, reduced, correlated and analyzed and is presented. Also presented are comparisons with previous types of correlations. These comparisons show that the boiloff data did not correlate with intensity. The data did correlate in the form used by Rott, that is boiloff versus TAO pressure squared times frequency to the one-half power. However, this latter correlation required a different set of correlation constants, slope and intercept, for each tube tested.
A simple shape-free model for pore-size estimation with positron annihilation lifetime spectroscopy
NASA Astrophysics Data System (ADS)
Wada, Ken; Hyodo, Toshio
2013-06-01
Positron annihilation lifetime spectroscopy is one of the methods for estimating pore size in insulating materials. We present a shape-free model to be used conveniently for such analysis. A basic model in classical picture is modified by introducing a parameter corresponding to an effective size of the positronium (Ps). This parameter is adjusted so that its Ps-lifetime to pore-size relation merges smoothly with that of the well-established Tao-Eldrup model (with modification involving the intrinsic Ps annihilation rate) applicable to very small pores. The combined model, i.e., modified Tao-Eldrup model for smaller pores and the modified classical model for larger pores, agrees surprisingly well with the quantum-mechanics based extended Tao-Eldrup model, which deals with Ps trapped in and thermally equilibrium with a rectangular pore.
A meta-analysis on the effectiveness of computer-assisted instruction in science education
NASA Astrophysics Data System (ADS)
Bayraktar, Sule
2000-10-01
The purposes of this study were to determine whether Computer-Assisted Instruction (CAI) had an overall positive effect on student achievement in secondary and college level science education when compared with traditional forms of instruction and to determine whether specific study or program characteristics were related to CAI effectiveness. This study employed a meta analytic research approach. First, the research studies comparing student achievement between CAI and traditional instruction in science were located by using electronic search databases. The search resulted in 42 studies producing 108 effect sizes. Second, the study features and effect sizes for each study were coded. Finally, the effect sizes provided from each study were combined to provide an overall effect size, and relationships between effect sizes and study features were then examined. The overall effect size was found to be 0.273 standard deviations, suggesting that CAI has a small positive effect on student achievement in science education at the college and secondary levels when compared with traditional forms of instruction. An effect size of 0.273 standard deviations indicates that an average student exposed to CAI exceeded the performance of 62% of the students who were taught by using traditional instructional methods. In other words, the typical student moved from the 50th percentile to the 62 nd percentile in science when CAI was used. All variables excluding school level and publication status were found to be related to effect sizes. According to the results of the analysis, CAI was most effective in physics education and had little effect on chemistry and biology achievement. Simulation and tutorial programs had significant effects on student achievement in science education but drill and practice was not found effective. The results also indicated that individual utilization of CAI was preferable. Another finding from the study is that experimenter-developed software was more
Attention is associated with postural control in those with chronic ankle instability.
Rosen, Adam B; Than, Nicholas T; Smith, William Z; Yentes, Jennifer M; McGrath, Melanie L; Mukherjee, Mukul; Myers, Sara A; Maerlender, Arthur C
2017-05-01
Chronic ankle instability (CAI) is often debilitating and may be affected by a number of intrinsic and environmental factors. Alterations in neurocognitive function and attention may contribute to repetitive injury in those with CAI and influence postural control strategies. Thus, the purpose of this study was to determine if there was a difference in attentional functioning and static postural control among groups of Comparison, Coper and CAI participants and assess the relationship between them within each of the groups. Recruited participants performed single-limb balance trials and completed the CNS Vital Signs (CNSVS) computer-based assessment to assess their attentional function. Center of pressure (COP) velocity (COPv) and maximum range (COPr), in both the anteroposterior (AP) and mediolateral (ML) directions were calculated from force plate data. Simple attention (SA), which measures self-regulation and attention control was extracted from the CNSVS. Data from 45 participants (15 in each group, 27=female, 18=male) was analyzed for this study. No significant differences were observed between attention or COP variables among each of the groups. However, significant relationships were present between attention and COP variables within the CAI group. CAI participants displayed significant moderate to large correlations between SA and AP COPr (r=-0.59, p=0.010), AP COPv (r=-0.48, p=0.038) and ML COPr (r=-0.47, p=0.034). The results suggest a linear relationship of stability and attention in the CAI group. Attentional self-regulation may moderate how those with CAI control postural stability. Incorporating neurocognitive training focused on attentional control may improve outcomes in those with CAI. Copyright © 2017 Elsevier B.V. All rights reserved.
Web-based training: a new paradigm in computer-assisted instruction in medicine.
Haag, M; Maylein, L; Leven, F J; Tönshoff, B; Haux, R
1999-01-01
Computer-assisted instruction (CAI) programs based on internet technologies, especially on the world wide web (WWW), provide new opportunities in medical education. The aim of this paper is to examine different aspects of such programs, which we call 'web-based training (WBT) programs', and to differentiate them from conventional CAI programs. First, we will distinguish five different interaction types: presentation; browsing; tutorial dialogue; drill and practice; and simulation. In contrast to conventional CAI, there are four architectural types of WBT programs: client-based; remote data and knowledge; distributed teaching; and server-based. We will discuss the implications of the different architectures for developing WBT software. WBT programs have to meet other requirements than conventional CAI programs. The most important tools and programming languages for developing WBT programs will be listed and assigned to the architecture types. For the future, we expect a trend from conventional CAI towards WBT programs.
Donnelly, Lindsy; Donovan, Luke; Hart, Joseph M; Hertel, Jay
2017-07-01
Individuals with chronic ankle instability (CAI) have demonstrated strength deficits compared to healthy controls; however, the influence of ankle position on force measures and surface electromyography (sEMG) activation of the peroneus longus and brevis has not been investigated. The purpose of this study was to compare sEMG amplitudes of the peroneus longus and brevis and eversion force measures in 2 testing positions, neutral and plantarflexion, in groups with and without CAI. Twenty-eight adults (19 females, 9 males) with CAI and 28 healthy controls (19 females, 9 males) participated. Hand-held dynamometer force measures were assessed during isometric eversion contractions in 2 testing positions (neutral, plantarflexion) while surface sEMG amplitudes of the peroneal muscles were recorded. Force measures were normalized to body mass, and sEMG amplitudes were normalized to a resting period. The group with CAI demonstrated less force when compared to the control group ( P < .001) in both the neutral and plantarflexion positions: neutral position, CAI: 1.64 Nm/kg and control: 2.10 Nm/kg) and plantarflexion position, CAI: 1.40 Nm/kg and control: 1.73 Nm/kg). There were no differences in sEMG amplitudes between the groups or muscles ( P > .05). Force measures correlated with both muscles' sEMG amplitudes in the healthy group (neutral peroneus longus: r = 0.42, P = .03; plantarflexion peroneus longus: r = 0.56, P = .002; neutral peroneus brevis: r = 0.38, P = .05; plantarflexion peroneus longus: r = 0.40, P = .04), but not in the group with CAI ( P > .05). The group with CAI generated less force when compared to the control group during both testing positions. There was no selective activation of the peroneal muscles with testing in both positions, and force output and sEMG activity was only related in the healthy group. Clinicians should assess eversion strength and implement strength training exercises in different sagittal plane positions and evaluate for other
NASA Technical Reports Server (NTRS)
Cuzzi, Jeffrey N.; Davis, Sanford S.; Dobrovolskis, Anthony R.
2003-01-01
Ca-Al rich refractory mineral inclusions (CAIs) found at 1-6% mass fraction in primitive chondrites appear to be 1-3 million years older than the dominant (chondrule) components which were accreted into the same parent bodies. A prevalent concern is that it is difficult to retain CAIs for this long against gas-drag-induced radial drift into the sun. We reassess the situation in terms of a hot inner (turbulent) nebula context for CAI formation, using analytical models of nebula evolution and particle diffusion. We show that outward radial diffusion in a weakly turbulent nebula can overwhelm inward drift, and prevent significant numbers of CAI-size particles from being lost into the sun for times on the order of 10(exp 6) years. CAIs can form early, when the inner nebula was hot, and persist in sufficient abundance to be incorporated into primitive planetesimals at a much later time. Small (less than or approx. equal to 0.1 mm diameter) CAIs persist for longer times than large (greater than or approx. equal to 5mm diameter ones). To obtain a quantitative match t o the observed volume fractions of CAIs in chondrites, another process must be allowed for: a substantial enhancement of the inner hot nebula in silicate-forming material, which we suggest was caused by rapid inward drift of meter-sized objects. This early in nebula history, the drifting rubble would have a carbon content probably an order of magnitude larger than even the most primitive (CI) carbonaceous chondrites. Abundant carbon in the evaporating material would help keep the nebula oxygen fugacity low, plausably solar, as inferred for the formation environment of CAIs. The associated production of a larger than canonical amount of CO2 might also play a role in mass-independent fractionation of oxygen isotopes, leaving the gas rich in l60 as inferred from CAIs and other high temperature condensates.
2005-03-01
bacterial peritonitis (8), chicken pox (9), and rhinovirus infection (10). In contrast, some studies have shown harmful effects of fever in animal models...March 1 - 6, 2005, Taos, New Mexico . 5. Chen, Q., Passanese, J., Fisher, D., Kucinska, S., Clancy, K., Wang, W.-C., Appenheimer, M., Zhou, L., Repasky...Travel award to attend Keystone Symposium, Leukocyte Trafficking: Cellular and Molecular Mechanisms, March 1 - 6, 2005, Taos, New Mexico . 2. Travel
Chou, Chung-Chuan; Zhou, Shengmei; Hayashi, Hideki; Nihei, Motoki; Liu, Yen-Bin; Wen, Ming-Shien; Yeh, San-Jou; Fishbein, Michael C; Weiss, James N; Lin, Shien-Fong; Wu, Delon; Chen, Peng-Sheng
2007-01-01
We hypothesize that remodelling of action potential and intracellular calcium (Cai) dynamics in the peri-infarct zone contributes to ventricular arrhythmogenesis in the postmyocardial infarction setting. To test this hypothesis, we performed simultaneous optical mapping of Cai and membrane potential (Vm) in the left ventricle in 15 rabbit hearts with myocardial infarction for 1 week. Ventricular premature beats frequently originated from the peri-infarct zone, and 37% showed elevation of Cai prior to Vm depolarization, suggesting reverse excitation–contraction coupling as their aetiology. During electrically induced ventricular fibrillation, the highest dominant frequency was in the peri-infarct zone in 61 of 70 episodes. The site of highest dominant frequency had steeper action potential duration restitution and was more susceptible to pacing-induced Cai alternans than sites remote from infarct. Wavebreaks during ventricular fibrillation tended to occur at sites of persistently elevated Cai. Infusion of propranolol flattened action potential duration restitution, reduced wavebreaks and converted ventricular fibrillation to ventricular tachycardia. We conclude that in the subacute phase of myocardial infarction, the peri-infarct zone exhibits regions with steep action potential duration restitution slope and unstable Cai dynamics. These changes may promote ventricular extrasystoles and increase the incidence of wavebreaks during ventricular fibrillation. Whereas increased tissue heterogeneity after subacute myocardial infarction creates a highly arrhythmogenic substrate, dynamic action potential and Cai cycling remodelling also contribute to the initiation and maintenance of ventricular fibrillation in this setting. PMID:17272354
NASA Astrophysics Data System (ADS)
Bastida, F.; Brime, C.; García-López, S.; Sarmiento, G. N.
The palaeotemperature distribution in the transition from diagenesis to metamorphism in the western nappes of the Cantabrian Zone (Somiedo, La Sobia and Aramo Units) are analysed by conodont colour alteration index (CAI) and illite crystallinity (IC). Structural and stratigraphic control in distribution of CAI and IC values is observed. Both CAI and IC value distributions show that anchizonal conditions are reached in the lower part of the Somiedo Unit. A disruption of the thermal trend by basal thrusts is evidenced by CAI and IC values. There is an apparent discrepancy between the IC and CAI values in Carboniferous rocks of the Aramo Unit; the IC has mainly anchizonal values, whereas the CAI has diagenetic values. Discrepant IC values are explained as a feature inherited from the source area. In the Carboniferous rocks of the La Sobia Unit, both IC and CAI indicate diagenetic conditions. The anchimetamorphism predated completion of emplacement of the major nappes; it probably developed previously and/or during the early stages of motion of the units. Temperature probably decreased when the metamorphosed zones of the sheets rose along ramps and were intensely eroded. In the context of the Iberian Variscan belt, influence of tectonic factors on the metamorphism is greater in the internal parts, where the strain and cleavage are always present, than in the external parts (Cantabrian Zone), where brittle deformation and rock translation are dominant, with an increasing role of the burial on the metamorphism.
A ceramic/slag interface as an analog for accretion of hot refractory objects and rim formation
NASA Technical Reports Server (NTRS)
Paque, J. M.; Bunch, T. E.
1994-01-01
Refractory inclusions or Ca-Al-rich inclusions (CAI's) from carbonaceous chondrites span a wide range of bulk compositions that cannot be explained either by segregation from a gas of solar composition at different points in the condensation sequence or by fractional crystallization from a parent liquid. CAI's are commonly rimmed by Wark-Lovering (W-L) rims, a series of nearly monomineralic layers that have been a source of controversy since the variety of rim sequences occurring on different types of CAI's from Allende were described. The origin of these distinctive features has not yet been resolved, with proponents of accretion, condensation, flash heating, ablation, evaporation, etc. Rims have generated considerable interest because they potentially contain clues to conditions experienced by CAI's after the formation of the inclusion and prior to incorporation into the parent body. Ceramic bricks in contact with hot steel slag may produce reaction products in rimlike fashion similar to those found in CAI's. The similarity between the mineralogy of blast furnace slags and CAI's has long been recognized, with both containing unusual phases not found in terrestrial materials. We provide here a comparison between a ceramic brick/slag multiple-layered interface and a multiple-layered interface between a melilite-perovskite object and a melilite-spinel object in the Allende inclusion USNM 4691-1. These results have implications in interpreting the origin of rims and the textures and compositions of CAI's.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ratzloff, Michael W.; Wilker, Molly B.; Mulder, David W.
Molecular complexes between CdSe nanocrystals and Clostridium acetobutylicum [FeFe] hydrogenase I (CaI) enabled light-driven control of electron transfer for spectroscopic detection of redox intermediates during catalytic proton reduction. Here in this paper we address the route of electron transfer from CdSe→CaI and activation thermodynamics of the initial step of proton reduction in CaI. The electron paramagnetic spectroscopy of illuminated CdSe:CaI showed how the CaI accessory FeS cluster chain (F-clusters) functions in electron transfer with CdSe. The H ox→H redH + reduction step measured by Fourier-transform infrared spectroscopy showed an enthalpy of activation of 19 kJ mol -1 and a ~2.5-foldmore » kinetic isotope effect. Overall these results support electron injection from CdSe into CaI involving F-clusters, and that the H ox→H redH + step of catalytic proton reduction in CaI proceeds by a proton-dependent process.« less
Ratzloff, Michael W; Wilker, Molly B; Mulder, David W; Lubner, Carolyn E; Hamby, Hayden; Brown, Katherine A; Dukovic, Gordana; King, Paul W
2017-09-20
Molecular complexes between CdSe nanocrystals and Clostridium acetobutylicum [FeFe] hydrogenase I (CaI) enabled light-driven control of electron transfer for spectroscopic detection of redox intermediates during catalytic proton reduction. Here we address the route of electron transfer from CdSe→CaI and activation thermodynamics of the initial step of proton reduction in CaI. The electron paramagnetic spectroscopy of illuminated CdSe:CaI showed how the CaI accessory FeS cluster chain (F-clusters) functions in electron transfer with CdSe. The H ox →H red H + reduction step measured by Fourier-transform infrared spectroscopy showed an enthalpy of activation of 19 kJ mol -1 and a ∼2.5-fold kinetic isotope effect. Overall, these results support electron injection from CdSe into CaI involving F-clusters, and that the H ox →H red H + step of catalytic proton reduction in CaI proceeds by a proton-dependent process.
Rouse, D P
2000-01-01
This study compared the effectiveness of three instructional intervention strategies for teaching nursing students about congenital heart disease (CHD). They are: (1) computer-assisted instruction (CAI), (2) traditional class room lecture (TCL); and (3) the combination of CAI and TCL. The subjects were associate degree nursing (ADN) students enrolled in a pediatric nursing course at the University of Cincinnati Raymond Walters College. Differences between pre- and post-scores on a 20-item multiple choice test were analyzed by analysis of variance. There was a significant improvement in scores for all groups but no significant difference in improvement in scores between the CAI group and the TCL group. The CAI/TCL group showed significant improvement in scores compared with the other two groups. The researcher concluded that when teaching strategies are comparable, CAI is as effective as TCL. Used together, a significant improvement is seen in student performance than when either strategy is used alone.
Rendos, Nicole K; Jun, Hyung-Pil; Pickett, Nancy M; Lew Feirman, Karen; Harriell, Kysha; Lee, Sae Yong; Signorile, Joseph F
2017-01-01
Chronic ankle instability (CAI) is a common condition following ankle injury that is associated with compromised balance. Whole body vibration training (WBVT) programmes are linked with improved balance and function in athletic and non-athletic populations and may improve balance in CAI. Twelve healthy and seven CAI participants completed two randomly assigned interventions. Two Power Plate® platforms were attached back to back using a Theraband®. Participants stood on the active plate and inactive plate for WBVT and sham interventions, respectively. Each intervention included vibration of the active plate. Centre of pressure (COP) and the star excursion balance test (SEBT) were measured before and at 3, 15 and 30 min following the interventions. Significant improvements were found in the anterior direction of the SEBT following both interventions in CAI and varying patterns of improvement were observed for COP measurements in all participants. Therefore, WBVT does not appear to acutely improve balance in CAI.
Calcium-aluminum-rich inclusions in the Allende meteorite - Evidence for a liquid origin
NASA Technical Reports Server (NTRS)
Blander, M.; Fuchs, L. H.
1975-01-01
We have made a detailed examination of the mineralogy, textures, and assemblages of six calcium-aluminum-rich inclusions (CAI) in the Allende meteorite. They can be classified into four types - hibonite-bearing, fassaite- and olivine-bearing, feldspathoid-bearing and fassaite-bearing CAI that are hibonite and olivine free. Examples of each type appear to have crystallized from a liquid rather than by agglomeration of solid nebular condensates. Some lines of evidence for a liquid origin are the presence of spherical and ovoid shapes and rims containing minerals that are more refractory than minerals inside the inclusion. Thermodynamic calculations and comparisons with liquidus phase diagrams indicate that the CAI could have been produced by direct condensation to metastable subcooled liquids that subsequently crystallized or by remelting of an equilibrium high-temperature condensate by impact. The diopside rims in some hibonite-bearing CAI and the paucity of metal in fassaite-olivine-bearing CAI are more consistent with direct condensation of a liquid.
Ratzloff, Michael W.; Wilker, Molly B.; Mulder, David W.; ...
2017-08-29
Molecular complexes between CdSe nanocrystals and Clostridium acetobutylicum [FeFe] hydrogenase I (CaI) enabled light-driven control of electron transfer for spectroscopic detection of redox intermediates during catalytic proton reduction. Here in this paper we address the route of electron transfer from CdSe→CaI and activation thermodynamics of the initial step of proton reduction in CaI. The electron paramagnetic spectroscopy of illuminated CdSe:CaI showed how the CaI accessory FeS cluster chain (F-clusters) functions in electron transfer with CdSe. The H ox→H redH + reduction step measured by Fourier-transform infrared spectroscopy showed an enthalpy of activation of 19 kJ mol -1 and a ~2.5-foldmore » kinetic isotope effect. Overall these results support electron injection from CdSe into CaI involving F-clusters, and that the H ox→H redH + step of catalytic proton reduction in CaI proceeds by a proton-dependent process.« less
NASA Technical Reports Server (NTRS)
Needham, A. W.; Messenger, S.
2013-01-01
Calcium, Aluminum-rich inclusions (CAIs) are composed of the suite of minerals predicted to be the first to condense from a cooling gas of solar composition [1]. Yet, the first phase to condense, corundum, is rare in CAIs, having mostly reacted to form hibonite followed by other phases at lower temperatures. Many CAIs show evidence of complex post-formational histories, including condensation, evaporation, and melting [e.g. 2, 3]. However, the nature of these thermal events and the nebular environments in which they took place are poorly constrained. Some corundum and corundum-hibonite grains appear to have survived or avoided these complex CAI reprocessing events. Such ultra-refractory CAIs may provide a clearer record of the O isotopic composition of the Sun and the evolution of the O isotopic composition of the planet-forming region [4-6]. Here we present in situ O and Mg isotopic analyses of two corundum/hibonite inclusions that record differing formation histories.
Rasool, Brwa; Marcus, Sue E.
2017-01-01
The mechanisms underpinning plant perception of phloem-feeding insects, particularly aphids, remain poorly characterized. Therefore, the role of apoplastic redox state in controlling aphid infestation was explored using transgenic tobacco (Nicotiana tabacum) plants that have either high (PAO) or low (TAO) ascorbate oxidase (AO) activities relative to the wild type. Only a small number of leaf transcripts and metabolites were changed in response to genotype, and cell wall composition was largely unaffected. Aphid fecundity was decreased significantly in TAO plants compared with other lines. Leaf sugar levels were increased and maximum extractable AO activities were decreased in response to aphids in all genotypes. Transcripts encoding the Respiratory Burst Oxidase Homolog F, signaling components involved in ethylene and other hormone-mediated pathways, photosynthetic electron transport components, sugar, amino acid, and cell wall metabolism, were increased significantly in the TAO plants in response to aphid perception relative to other lines. The levels of galactosylated xyloglucan were decreased significantly in response to aphid feeding in all the lines, the effect being the least in the TAO plants. Similarly, all lines exhibited increases in tightly bound (1→4)-β-galactan. Taken together, these findings identify AO-dependent mechanisms that limit aphid infestation. PMID:28743764
Deviations in gait metrics in patients with chronic ankle instability: a case control study.
Gigi, Roy; Haim, Amir; Luger, Elchanan; Segal, Ganit; Melamed, Eyal; Beer, Yiftah; Nof, Matityahu; Nyska, Meir; Elbaz, Avi
2015-01-01
Gait metric alterations have been previously reported in patients suffering from chronic ankle instability (CAI). Previous studies of gait in this population have been comprised of relatively small cohorts, and the findings of these studies are not uniform. The objective of the present study was to examine spatiotemporal gait metrics in patients with CAI and examine the relationship between self-reported disease severity and the magnitude of gait abnormalities. Forty-four patients with CAI were identified and compared to 53 healthy controls. Patients were evaluated with spatiotemporal gait analysis via a computerized mat and with the Short Form (SF) - 36 health survey. Patients with CAI were found to walk with approximately 16% slower walking velocity, 9% lower cadence and approximately 7% lower step length. Furthermore, the base of support, during walking, in the CAI group was approximately 43% wider, and the single limb support phase was 3.5% shorter compared to the control group. All of the SF-36 8-subscales, as well as the SF-36 physical component summary and SF-36 mental component summary, were significantly lower in patients with CAI compared to the control group. Finally, significant correlations were found between most of the objective gait measures and the SF-36 mental component summary and SF-36 physical component summary. The results outline a gait profile for patients suffering from CAI. Significant differences were found in most spatiotemporal gait metrics. An important finding was a significantly wider base of support. It may be speculated that these gait alterations may reflect a strategy to deal with imbalance and pain. These findings suggest the usefulness of gait metrics, alongside with the use of self-evaluation questionnaires, in assessing disease severity of patients with CAI.
Effect of metabolic and respiratory acidosis on intracellular calcium in osteoblasts
Bushinsky, David A.
2010-01-01
In vivo, metabolic acidosis {decreased pH from decreased bicarbonate concentration ([HCO3−])} increases urine calcium (Ca) without increased intestinal Ca absorption, resulting in a loss of bone Ca. Conversely, respiratory acidosis [decreased pH from increased partial pressure of carbon dioxide (Pco2)] does not appreciably alter Ca homeostasis. In cultured bone, chronic metabolic acidosis (Met) significantly increases cell-mediated net Ca efflux while isohydric respiratory acidosis (Resp) does not. The proton receptor, OGR1, appears critical for cell-mediated, metabolic acid-induced bone resorption. Perfusion of primary bone cells or OGR1-transfected Chinese hamster ovary (CHO) cells with Met induces transient peaks of intracellular Ca (Cai). To determine whether Resp increases Cai, as does Met, we imaged Cai in primary cultures of bone cells. pH for Met = 7.07 ([HCO3−] = 11.8 mM) and for Resp = 7.13 (Pco2 = 88.4 mmHg) were similar and lower than neutral (7.41). Both Met and Resp induced a marked, transient increase in Cai in individual bone cells; however, Met stimulated Cai to a greater extent than Resp. We used OGR1-transfected CHO cells to determine whether OGR1 was responsible for the greater increase in Cai in Met than Resp. Both Met and Resp induced a marked, transient increase in Cai in OGR1-transfected CHO cells; however, in these cells Met was not different than Resp. Thus, the greater induction of Cai by Met in primary bone cells is not a function of OGR1 alone, but must involve H+ receptors other than OGR1, or pathways sensitive to Pco2, HCO3−, or total CO2 that modify the effect of H+ in primary bone cells. PMID:20504884
Wilson, Adam B; Brown, Kirsten M; Misch, Jonathan; Miller, Corinne H; Klein, Barbie A; Taylor, Melissa A; Goodwin, Michael; Boyle, Eve K; Hoppe, Chantal; Lazarus, Michelle D
2018-04-16
While prior meta-analyses in anatomy education have explored the effects of laboratory pedagogies and histology media on learner performance, the effects of student-centered learning (SCL) and computer-aided instruction (CAI) have not been broadly evaluated. This research sought to answer the question, "How effective are student-centered pedagogies and CAI at increasing student knowledge gains in anatomy compared to traditional didactic approaches?" Relevant studies published within the past 51 years were searched using five databases. Predetermined eligibility criteria were applied to the screening of titles and abstracts to discern their appropriateness for study inclusion. A summary effect size was estimated to determine the effects of SCL and CAI on anatomy performance outcomes. A moderator analysis of study features was also performed. Of the 3,035 records screened, 327 underwent full-text review. Seven studies, which comprised 1,564 participants, were included in the SCL analysis. An additional 19 studies analyzed the effects of CAI in the context of 2,570 participants. Upon comparing SCL to traditional instruction, a small positive effect on learner performance was detected (standardized mean difference (SMD = 0.24; [CI = 0.07, 0.42]; P = 0.006). Likewise, students with CAI exposure moderately outscored those with limited or no access to CAI (SMD = 0.59; [CI = 0.20, 0.98]; P = 0.003). Further analysis of CAI studies identified effects (P ≤ 0.001) for learner population, publication period, interventional approach, and intervention frequency. Overall, learners exposed to SCL and supplemental CAI outperformed their more classically-trained peers as evidenced by increases in short-term knowledge gains. Anat Sci Educ. © 2018 American Association of Anatomists. © 2018 American Association of Anatomists.
Effect of metabolic and respiratory acidosis on intracellular calcium in osteoblasts.
Frick, Kevin K; Bushinsky, David A
2010-08-01
In vivo, metabolic acidosis {decreased pH from decreased bicarbonate concentration ([HCO(3)(-)])} increases urine calcium (Ca) without increased intestinal Ca absorption, resulting in a loss of bone Ca. Conversely, respiratory acidosis [decreased pH from increased partial pressure of carbon dioxide (Pco(2))] does not appreciably alter Ca homeostasis. In cultured bone, chronic metabolic acidosis (Met) significantly increases cell-mediated net Ca efflux while isohydric respiratory acidosis (Resp) does not. The proton receptor, OGR1, appears critical for cell-mediated, metabolic acid-induced bone resorption. Perfusion of primary bone cells or OGR1-transfected Chinese hamster ovary (CHO) cells with Met induces transient peaks of intracellular Ca (Ca(i)). To determine whether Resp increases Ca(i), as does Met, we imaged Ca(i) in primary cultures of bone cells. pH for Met = 7.07 ([HCO(3)(-)] = 11.8 mM) and for Resp = 7.13 (Pco(2) = 88.4 mmHg) were similar and lower than neutral (7.41). Both Met and Resp induced a marked, transient increase in Ca(i) in individual bone cells; however, Met stimulated Ca(i) to a greater extent than Resp. We used OGR1-transfected CHO cells to determine whether OGR1 was responsible for the greater increase in Ca(i) in Met than Resp. Both Met and Resp induced a marked, transient increase in Ca(i) in OGR1-transfected CHO cells; however, in these cells Met was not different than Resp. Thus, the greater induction of Ca(i) by Met in primary bone cells is not a function of OGR1 alone, but must involve H(+) receptors other than OGR1, or pathways sensitive to Pco(2), HCO(3)(-), or total CO(2) that modify the effect of H(+) in primary bone cells.
Hwang, Gyo-Seung; Tang, Liang; Joung, Boyoung; Morita, Norishige; Hayashi, Hideki; Karagueuzian, Hrayr S; Weiss, James N; Lin, Shien-Fong; Chen, Peng-Sheng
2008-09-02
The purpose of this study was to test the hypothesis that superiority of biphasic waveform (BW) over monophasic waveform (MW) defibrillation shocks is attributable to less intracellular calcium (Ca(i)) transient heterogeneity. The mechanism by which BW shocks have a higher defibrillation efficacy than MW shocks remains unclear. We simultaneously mapped epicardial membrane potential (Vm) and Ca(i) during 6-ms MW and 3-ms/3-ms BW shocks in 19 Langendorff-perfused rabbit ventricles. After shock, the percentage of depolarized area was plotted over time. The maximum (peak) post-shock values (VmP and Ca(i)P, respectively) were used to measure heterogeneity. Higher VmP and Ca(i)P imply less heterogeneity. The defibrillation thresholds for BW and MW shocks were 288 +/- 99 V and 399 +/- 155 V, respectively (p = 0.0005). Successful BW shocks had higher VmP (88 +/- 9%) and Ca(i)P (70 +/- 13%) than unsuccessful MW shocks (VmP 76 +/- 10%, p < 0.001; Ca(i)P 57 +/- 8%, p < 0.001) of the same shock strength. In contrast, for unsuccessful BW and MW shocks of the same shock strengths, the VmP and Ca(i)P were not significantly different. The MW shocks more frequently created regions of low Ca(i) surrounded by regions of high Ca(i) (post-shock Ca(i) sinkholes). The defibrillation threshold for MW and BW shocks became similar after disabling the sarcoplasmic reticulum (SR) with thapsigargin and ryanodine. The greater efficacy of BW shocks is directly related to their less heterogeneous effects on shock-induced SR Ca release and Ca(i) transients. Less heterogeneous Ca(i) transients reduces the probability of Ca(i) sinkhole formation, thereby preventing the post-shock reinitiation of ventricular fibrillation.
Hayashi, Hideki; Kamanu, Santosh Dora; Ono, Norihiko; Kawase, Ayaka; Chou, Chung-Chuan; Weiss, James N.; Karagueuzian, Hrayr S.; Lin, Shien-Fong; Chen, Peng-Sheng
2009-01-01
BACKGROUND Single strong premature electrical stimulation (S2) may induce figure-eight reentry. We hypothesize that Ca current-mediated slow-response action potentials (APs) play a key role in the propagation in the central common pathway (CCP) of the reentry. METHODS We simultaneously mapped optical membrane potential (Vm) and intracellular Ca (Cai) transients in isolated Langendorff-perfused rabbit ventricles. Baseline pacing (S1) and a cathodal S2 (40 – 80 mA) were given at different epicardial sites with a coupling interval of 135 ± 20 ms. RESULTS In all 6 hearts, S2 induced graded responses around the S2 site. These graded responses propagated locally toward the S1 site and initiated fast APs from recovered tissues. The wavefront then circled around the refractory tissue near the site of S2. At the side of S2 opposite to the S1, the graded responses prolonged AP duration while the Cai continued to decline, resulting in a Cai sinkhole (an area of low Cai). The Cai in the sinkhole then spontaneously increased, followed by a slow Vm depolarization with a take-off potential of −40 ± 3.9 mV, which was confirmed with microelectrode recordings in 3 hearts. These slow-response APs then propagated through CCP to complete a figure-eight reentry. CONCLUSION We conclude that a strong premature stimulus can induce a Cai sinkhole at the entrance of the CCP. Spontaneous Cai elevation in the Cai sinkhole precedes the Vm depolarization, leading to Ca current-mediated slow propagation in the CCP. The slow propagation allows more time for tissues at the other side of CCP to recover and be excited to complete figure-eight reentry. PMID:18180025
Hayashi, Hideki; Kamanu, Santosh Dora; Ono, Norihiko; Kawase, Ayaka; Chou, Chung-Chuan; Weiss, James N; Karagueuzian, Hrayr S; Lin, Shien-Fong; Chen, Peng-Sheng
2008-01-01
Single strong premature electrical stimulation (S(2)) may induce figure-eight reentry. We hypothesize that Ca current-mediated slow-response action potentials (APs) play a key role in the propagation in the central common pathway (CCP) of the reentry. We simultaneously mapped optical membrane potential (V(m)) and intracellular Ca (Ca(i)) transients in isolated Langendorff-perfused rabbit ventricles. Baseline pacing (S(1)) and a cathodal S(2) (40-80 mA) were given at different epicardial sites with a coupling interval of 135 +/- 20 ms. In all 6 hearts, S(2) induced graded responses around the S(2) site. These graded responses propagated locally toward the S(1) site and initiated fast APs from recovered tissues. The wavefront then circled around the refractory tissue near the site of S(2). At the side of S(2) opposite to the S(1), the graded responses prolonged AP duration while the Ca(i) continued to decline, resulting in a Ca(i) sinkhole (an area of low Ca(i)). The Ca(i) in the sinkhole then spontaneously increased, followed by a slow V(m) depolarization with a take-off potential of -40 +/- 3.9 mV, which was confirmed with microelectrode recordings in 3 hearts. These slow-response APs then propagated through CCP to complete a figure-eight reentry. We conclude that a strong premature stimulus can induce a Ca(i) sinkhole at the entrance of the CCP. Spontaneous Ca(i) elevation in the Ca(i) sinkhole precedes the V(m) depolarization, leading to Ca current-mediated slow propagation in the CCP. The slow propagation allows more time for tissues at the other side of CCP to recover and be excited to complete figure-eight reentry.
Refractory inclusions from the ungrouped carbonaceous chondrites MAC 87300 and MAC 88107
NASA Astrophysics Data System (ADS)
Russell, Sara S.; Davis, Andrew M.; MacPherson, Glenn J.; Guan, Yunbin; Huss, Gary R.
2000-09-01
MAC 87300 and MAC 88107 are two unusual carbonaceous chondrites that are intermediate in chemical composition between the CO3 and CM2 meteorite groups. Calcium-aluminum-rich inclusions (CAIs) from these two meteorites are mostly spinel-pyroxene and melilite-rich (Type A) varieties. Spinel-pyroxene inclusions have either a banded or nodular texture, with aluminous diopside rimming iron-poor spinel. Melilite-rich inclusions (4-42) are irregular in shape and contain minor spinel (FeO <1 wt%), perovskite and, more rarely, hibonite. The CAIs in MAC 88107 and MAC 87300 are similar in primary mineralogy to CAIs from low petrologic grade CO3 meteorites, but differ in that they commonly contain phyllosilicates. The two meteorites also differ somewhat from each other: melilite is more abundant and slightly more aluminum-rich in inclusions from MAC 88107 than in those from MAC 87300, and phyllosilicate is more abundant and magnesium-poor in MAC 87300 CAIs relative to that in MAC 88107. These differences suggest that the two meteorites are not paired. CAI sizes and the abundance of melilite-rich CAIs in MAC 88107 and MAC 87300 suggests a genetic relationship to CO3 meteorites, but the CAIs in both have suffered a greater degree of aqueous alteration than is observed in COs. Al-rich melilite in CAIs from both meteorites generally contains excess 26Mg, presumably from the in situ decay of 26Al. Although well-defined isochrons are not observed, the 26Mg excesses are consistent with initial 26Al/27Al ~3-5 ( 10-5. An unusual hibonite-bearing inclusion is isotopically heterogeneous, with two large and abutting hibonite crystals showing significant differences in their degrees of mass-dependent fractionation of 25Mg/24Mg. The two crystals also show differences in their inferred initial 26Al/27Al, 1 ( 10-5 vs. 3 ( 10-6.
NASA Astrophysics Data System (ADS)
Peters, Stefan T. M.; Münker, Carsten; Pfeifer, Markus; Elfers, Bo-Magnus; Sprung, Peter
2017-02-01
Some nuclides that were produced in supernovae are heterogeneously distributed between different meteoritic materials. In some cases these heterogeneities have been interpreted as the result of interaction between ejecta from a nearby supernova and the nascent solar system. Particularly in the case of the oldest objects that formed in the solar system - Ca-Al rich inclusions (CAIs) - this view is confirm the hypothesis that a nearby supernova event facilitated or even triggered solar system formation. We present Hf isotope data for bulk meteorites, terrestrial materials and CAIs, for the first time including the low-abundance isotope 174Hf (∼0.16%). This rare isotope was likely produced during explosive O/Ne shell burning in massive stars (i.e., the classical "p-process"), and therefore its abundance potentially provides a sensitive tracer for putative heterogeneities within the solar system that were introduced by supernova ejecta. For CAIs and one LL chondrite, also complementary W isotope data are reported for the same sample cuts. Once corrected for small neutron capture effects, different chondrite groups, eucrites, a silicate inclusion of a IAB iron meteorite, and terrestrial materials display homogeneous Hf isotope compositions including 174Hf. Hafnium-174 was thus uniformly distributed in the inner solar system when planetesimals formed at the <50 ppm level. This finding is in good agreement with the evidently homogeneous distributions of p-process isotopes 180W, 184Os and possibly 190Pt between different iron meteorite groups. In contrast to bulk meteorite samples, CAIs show variable depletions in p-process 174Hf with respect to the inner solar system composition, and also variable r-process (or s-process) Hf and W contributions. Based on combined Hf and W isotope compositions, we show that CAIs sampled at least one component in which the proportion of r- and s-process derived Hf and W deviates from that of supernova ejecta. The Hf and W isotope
Oxygen isotope exchange between refractory inclusion in Allende and solar nebula gas.
Yurimoto, H; Ito, M; Nagasawa, H
1998-12-04
A calcium-aluminum-rich inclusion (CAI) from the Allende meteorite was analyzed and found to contain melilite crystals with extreme oxygen-isotope composition (approximately 5 percent oxygen-16 enrichment relative to terrestrial oxygen-16). Some of the melilite is also anomalously enriched in oxygen-16 compared with oxygen isotopes measured in other CAIs. The oxygen isotopic variation measured among the minerals (melilite, spinel, and fassaite) indicates that crystallization of the CAI started from oxygen-16-rich materials that were probably liquid droplets in the solar nebula, and oxygen isotope exchange with the surrounding oxygen-16-poor nebular gas progressed through the crystallization of the CAI. Additional oxygen isotope exchange also occurred during subsequent reheating events in the solar nebula.
Oxygen isotope exchange between refractory inclusion in allende and solar nebula Gas
Yurimoto; Ito; Nagasawa
1998-12-04
A calcium-aluminum-rich inclusion (CAI) from the Allende meteorite was analyzed and found to contain melilite crystals with extreme oxygen-isotope compositions ( approximately 5 percent oxygen-16 enrichment relative to terrestrial oxygen-16). Some of the melilite is also anomalously enriched in oxygen-16 compared with oxygen isotopes measured in other CAIs. The oxygen isotopic variation measured among the minerals (melilite, spinel, and fassaite) indicates that crystallization of the CAI started from oxygen-16-rich materials that were probably liquid droplets in the solar nebula, and oxygen isotope exchange with the surrounding oxygen-16-poor nebular gas progressed through the crystallization of the CAI. Additional oxygen isotope exchange also occurred during subsequent reheating events in the solar nebula.
Worldwide Report, Arms Control
1985-09-25
Chemical Weapons Proposal to FRG (East Berlin ADN International Service, 13, 16 Sep 85) 36 36 36 NUCLEAR-FREE-ZONE PROPOSALS Fiji ...Christians Urged To Ban Nuclear Warships (Suva THE FIJI TIMES, 24 Aug 85) 38 NUCLEAR TESTING 39 JPRS-TAO85-035 25 September 1985 SDI AND SPACE...in the world, the analyst writes in conclusion. (APN, August 20. In full .) CSO: 5200/1395 JPRS-TAO85-035 25 September 1985 SDI AND SPACE
DOE Office of Scientific and Technical Information (OSTI.GOV)
Tsunekawa, S.; Fukuda, T.; Kimiyama, T.
Crystal structure analyses by TOF neutron powder diffraction are performed for R TaO{sub 4} (R = rare-earth element) and the Ta-O interatomic distances are determined. The relationship between the covalency of A-O bonds (A = Nb and Ta), which show the most shortening upon phase transition, and the transition temperature is discussed for RAO{sub 4} and LiAO{sub 3}, and the parameters of Ta-O covalence are determined.
The Restricted Isometry Property for Time-Frequency Structured Random Matrices
2011-06-16
tests illustrating the use of Ψg for compressive sensing are presented in [41]. They illustrate that empirically Ψg performs very similarly to a...E.J., J., Tao, T., Romberg , J.: Robust uncertainty principles: exact signal reconstruction from highly incomplete frequency information. IEEE Trans...Inform. Theory 52(2), 489–509 (2006) [12] Candès, E.J., Romberg , J., Tao, T.: Stable signal recovery from incomplete and inaccurate mea- surements. Comm
Simpson, Jeffrey D; Stewart, Ethan M; Macias, David M; Chander, Harish; Knight, Adam C
2018-06-13
To evaluate the literature regarding unilateral landing biomechanics and dynamic postural stability in individuals with and without chronic ankle instability (CAI). Four online databases (PubMed, ScienceDirect, Scopus, and SportDiscus) were searched from the earliest records to 31 January 2018, as well as reference sections of related journal articles, to complete the systematic search. Studies investigating the influence of CAI on unilateral landing biomechanics and dynamic postural stability were systematically reviewed and evaluated. Twenty articles met the criteria and were included in the systematic review. Individuals with CAI were found to have deficits in dynamic postural stability on the affected limb with medium to large effect sizes and altered lower extremity kinematics, most notably in the ankle and knee, with medium to large effect sizes. Additionally, greater loading rates and peak ground reaction forces, in addition to reductions in ankle muscle activity were also found in individuals with CAI during unilateral jump-landing tasks. Individuals with CAI demonstrate dynamic postural stability deficits, lower extremity kinematic alterations, and reduced neuromuscular control during unilateral jump-landings. These are likely factors that contribute recurrent lateral ankle sprain injuries during dynamic activity in individuals with CAI. Copyright © 2018 Elsevier Ltd. All rights reserved.
BG60S dissolution interferes with osteoblast calcium signals.
Valério, P; Pereira, M M; Goes, A M; Leite, M F
2007-02-01
We investigated the influence of extracellular calcium concentration, caused by the dissolution of a bioactive glass with 60% of silicon (BG60S), on intracellular calcium (Ca(i) (2 +)) signals and expression of inositol 1, 4, 5-triphosphate receptors (InsP(3)R) in primary culture of osteoblasts. We found that BG60S caused an increase in Ca(i) (2 +) signals in this cell type. Additionally, osteoblasts pre-incubated in the presence of BG60S showed an increase in Ca(i) (2 +) when cells were stimulated with vasopressin. On the other hand, a decrease in Ca(i) (2 +) signals were observed in osteoblasts pre-treated with BG60S and stimulated with KCl. We furher found that in osteoblasts, the type I InsP(3)R is preferentially distributed in the nucleus while the type II InsP(3)R in the cytoplasm. Preincubation of osteoblasts with BG60S altered the receptor expression level, increasing the type I InsP(3)R in the nucleus and decreasing type II InsP(3)R in the cytosol. Together, our results showed that in osteoblasts, BG60S increased Ca(i) (2 +)signals and altered Ca(i) (2 +) machinery.
Conodont color alteration index and upper Paleozoic thermal history of the Amazonas Basin, Brazil
NASA Astrophysics Data System (ADS)
Cardoso, Cassiane Negreiros; Sanz-López, Javier; Blanco-Ferrera, Silvia; Lemos, Valesca Brasil; Scomazzon, Ana Karina
2015-12-01
The conodont color alteration index (CAI) was determined in elements from core samples of the Frasnian Barreirinha Formation (one well) and of the Pennsylvanian-Permian Tapajós Group (twenty three wells and one limestone quarry) in the Amazonas Basin. The thermal history of the basin is analyzed using the CAI value distribution represented in maps and stratigraphic sections through correlation schemes, and in conjunction with previously published data. The pattern of palaeotemperatures for CAI values of 1.5-3 is coincident with organic matter maturation under a sedimentary overburden providing diagenetic conditions in the oil/gas window. Locally, conodonts show metamorphism (CAI value of 6-7) in relation to the intrusion of diabase bodies in beds including high geothermal gradient evaporites. Microtextural alteration on the surface conodonts commonly shows several types of overgrowth microtextures developed in diagenetic conditions. Locally, recrystallization in conodonts with a high CAI value is congruent with contact metamorphism in relation to Mesozoic intrusions. The CAI values of 1.5 or 2 observed close to the surface in several areas of the basin may be interpreted in relation to a high thermal palaeogradient derived from the magmatic episode or/and to the local denudation of the upper part of the Paleozoic succession prior to this thermal event.
Cao, Huojun; Amendt, Brad A
2016-11-01
Developmental dental anomalies are common forms of congenital defects. The molecular mechanisms of dental anomalies are poorly understood. Systematic approaches such as clustering genes based on similar expression patterns could identify novel genes involved in dental anomalies and provide a framework for understanding molecular regulatory mechanisms of these genes during tooth development (odontogenesis). A python package (pySAPC) of sparse affinity propagation clustering algorithm for large datasets was developed. Whole genome pair-wise similarity was calculated based on expression pattern similarity based on 45 microarrays of several stages during odontogenesis. pySAPC identified 743 gene clusters based on expression pattern similarity during mouse tooth development. Three clusters are significantly enriched for genes associated with dental anomalies (with FDR <0.1). The three clusters of genes have distinct expression patterns during odontogenesis. Clustering genes based on similar expression profiles recovered several known regulatory relationships for genes involved in odontogenesis, as well as many novel genes that may be involved with the same genetic pathways as genes that have already been shown to contribute to dental defects. By using sparse similarity matrix, pySAPC use much less memory and CPU time compared with the original affinity propagation program that uses a full similarity matrix. This python package will be useful for many applications where dataset(s) are too large to use full similarity matrix. This article is part of a Special Issue entitled "System Genetics" Guest Editor: Dr. Yudong Cai and Dr. Tao Huang. Copyright © 2016. Published by Elsevier B.V.
NASA Astrophysics Data System (ADS)
MacPherson, G. J.; Defouilloy, C.; Kita, N. T.
2018-06-01
The Allende CAI USNM 3898 is the basis for "ALL", the lowest measured initial 87Sr/86Sr value in any solar system material including other CAIs (Gray et al., 1973). If the value ALL is correct (debated), then USNM 3898 must be 1-2 million years older than other CAIs (Podosek et al., 1991). This would require in turn that it have a much higher initial 26Al/27Al value than other CAIs, on the order of 4 × 10-4. Podosek et al. (1991) showed that this is not the case, with initial 26Al/27Al = (4.5 ± 0.7) × 10-5, but their Mg-isotopic data had large error bars and there was clear isotopic disturbance in the data having the highest 27Al/24Mg. Without the latter data, the slope of their isochron is higher (5.10 ± 1.19) × 10-5) and within (large) error of being supracanonical. We used high-precision SIMS to re-determine the initial 26Al/27Al in this CAI and obtained a value of (5.013 ± 0.099) × 10-5, with an intercept δ26Mg* = - 0.008 ± 0.048 and MSWD = 1.3. This value is indistinguishable from that measured in many other CAIs and conclusively shows that USNM 3898 is not uniquely ancient. We also confirmed evidence of later isotopic disturbance, similar to what Podosek et al. found, indicating a re-melting and evaporation event some 200,000 years after initial CAI solidification.
Neural Excitability and Joint Laxity in Chronic Ankle Instability, Coper, and Control Groups
Bowker, Samantha; Terada, Masafumi; Thomas, Abbey C.; Pietrosimone, Brian G.; Hiller, Claire E.; Gribble, Phillip A.
2016-01-01
Context: Neuromuscular and mechanical deficiencies are commonly studied in participants with chronic ankle instability (CAI). Few investigators have attempted to comprehensively consider sensorimotor and mechanical differences among people with CAI, copers who did not present with prolonged dysfunctions after an initial ankle sprain, and a healthy control group. Objective: To determine if differences exist in spinal reflex excitability and ankle laxity among participants with CAI, copers, and healthy controls. Design: Case-control study. Setting: Research laboratory. Patients or Other Participants: Thirty-seven participants with CAI, 30 participants categorized as copers, and 26 healthy control participants. Main Outcome Measure(s): We assessed spinal reflex excitability of the soleus using the Hoffmann reflex protocol. Participants' ankle laxity was measured with an instrumented ankle arthrometer. The maximum Hoffmann reflex : maximal muscle response ratio was calculated. Ankle laxity was measured as the total displacement in the anterior-posterior directions (mm) and total rotation in the inversion and eversion directions (°). Results: Spinal reflex excitability was diminished in participants with CAI compared with copers and control participants (P = .01). No differences were observed among any of the groups for ankle laxity. Conclusion: Changes in the spinal reflex excitability of the soleus that likely affect ankle stability were seen only in the CAI group, yet no mechanical differences were noted across the groups. These findings support the importance of finding effective ways to increase spinal reflex excitability for the purpose of treating neural excitability dysfunction in patients with CAI. PMID:27065189
Condomless anal intercourse among males and females at high risk for heterosexual HIV infection
German, Danielle; Nguyen, Trang; Ogbue, Christine Powell; Flynn, Colin
2015-01-01
Background Understanding and addressing heterosexual HIV transmission requires attention to the range and context of heterosexual sexual behaviors. We sought to determine population-based prevalence of condomless anal intercourse (CAI) among individuals at increased heterosexual HIV risk in Baltimore and to identify demographic, behavioral, and health related correlates. Methods Data were from a cross-sectional study of 185 males and 198 females at increased heterosexual risk for HIV recruited using respondent driven sampling as part of CDC's National HIV Behavioral Surveillance Project in Baltimore, August-December 2010. Bivariate and multivariate logistic regression examined factors associated with heterosexual CAI. Results The sample was majority African-American, with mean age of 38 among men and 34 among women. Forty-two percent of men (95% C.I.: 30.9, 52.0%) and 38% of women (95% C.I.: 29.4, 47.2%) reported any CAI in the past year, with variance by partner type and gender. Among men, CAI was significantly associated with homelessness, casual and exchange partners, same sex partner in past year, and substance use. Among women, CAI was significantly associated with lower education, casual and exchange partners, same sex partner in past year, multiple partners, and substance use. In adjusted gender-specific models, males and females with increasing numbers of partners were more likely to engage in CAI. Conclusions It is important to recognize the efficiency of transmission of HIV and other STIs through CAI. There is a need to broaden heterosexual sexual health promotion and HIV/STI prevention to adequately and appropriately address risks and prevention strategies for anal intercourse. PMID:25970308
NASA Astrophysics Data System (ADS)
Koukina, S. E.; Lobus, N. V.; Peresypkin, V. I.; Dara, O. M.; Smurov, A. V.
2017-11-01
Major (Si, Al, Fe, Ti, Mg, Ca, Na, K, S, P), minor (Mn) and trace (Li, V, Cr, Co, Ni, Cu, Zn, As, Sr, Zr, Mo, Cd, Ag, Sn, Sb, Cs, Ba, Hg, Pb, Bi and U) elements, their chemical forms and the mineral composition, organic matter (TOC) and carbonates (TIC) in surface sediments from the Cai River estuary and Nha Trang Bay were first determined along the salinity gradient. The abundance and ratio of major and trace elements in surface sediments are discussed in relation to the mineralogy, grain size, depositional conditions, reference background and SQG values. Most trace-element contents are at natural levels and are derived from the composition of rocks and soils in the watershed. A severe enrichment of Ag is most likely derived from metal-rich detrital heavy minerals such as Ag-sulfosalts. Along the salinity gradient, several zones of metal enrichment occur in surface sediments because of the geochemical fractionation of the riverine material. The parts of actually and potentially bioavailable forms (isolated by four single chemical reagent extractions) are most elevated for Mn and Pb (up to 36% and 32% of total content, respectively). The possible anthropogenic input of Pb in the region requires further study. Overall, the most bioavailable parts of trace elements are associated with easily soluble amorphous Fe and Mn oxyhydroxides. The sediments are primarily enriched with bioavailable metal forms in the riverine part of the estuary. Natural (such as turbidities) and human-generated (such as urban and industrial activities) pressures are shown to influence the abundance and speciation of potential contaminants and therefore change their bioavailability in this estuarine system.
NASA Astrophysics Data System (ADS)
Mendybaev, Ruslan A.; Williams, Curtis D.; Spicuzza, Michael J.; Richter, Frank M.; Valley, John W.; Fedkin, Alexei V.; Wadhwa, Meenakshi
2017-03-01
We present the results of laboratory experiments in which a forsterite-rich melt estimated to be a potential precursor of Allende CMS-1 FUN CAI was evaporated into vacuum for different lengths of time at 1900 °C. The evaporation of this melt resulted in residues that define trajectories in chemical as well as magnesium, silicon and oxygen isotopic composition space and come very close to the measured properties of CMS-1. The isotopic composition of the evaporation residues was also used to determine the kinetic isotopic fractionation factors [α2,1 (vapor-melt) defined as the ratio of isotopes 2 and 1 of a given element in the evaporating gas divided by their ratio in the evaporating source] for evaporation of magnesium (α25,24 for 25Mg/24Mg), silicon (α29,28 for 29Si/28Si) and oxygen (α18,16 for 18O/16O) from the forsterite-rich melt at 1900 °C. The values of α25,24 = 0.98383 ± 0.00033 and α29,28 = 0.99010 ± 0.00038 are essentially independent of change in the melt composition as evaporation proceeds. In contrast, α18,16 changes from 0.9815 ± 0.0016 to ∼0.9911 when the residual melt composition changes from forsteritic to melilitic. Using the determined values of α25,24 and α29,28 and present-day bulk chemical composition of the CMS-1, the composition of the precursor of the inclusion was estimated to be close to the clinopyroxene + spinel + forsterite assemblage condensed from a solar composition gas. The correspondence between the chemical composition and isotopic fractionation of experimental evaporation residues and the present-day bulk chemical and isotopic compositions of CMS-1 is evidence that evaporation played a major role in the chemical evolution of CMS-1.
NASA Astrophysics Data System (ADS)
Gómez-García, J. Francisco; Bucio, Lauro; Tavizon, Gustavo
2018-01-01
In this work, we present both structural and magnetic (DC magnetization and AC susceptibility) studies of the Dy3-xYxTaO7 solid solution. The structural characterization of samples was performed by Rietveld refinements of the X-ray diffraction data. All compounds crystallized in a weberite-related structure in the orthorhombic C2221 space group (No. 20); the variations of the lattice parameters obey the Vegard´s law in the whole range of composition. DC magnetic measurements of the Dy3-xYxTaO7 system showed a Curie-Weiss paramagnetic behaviour, with antiferromagnetic interactions at T>150 K. Below 3 K a spin glass behaviour in the 0 ≤ x ≤ 1 range of the solid solution was observed. The stoichiometric Dy3TaO7 compound showed spin glass behaviour although there is no evidence of structural disorder. For some Y3+ doped compounds (x = 0.33, 0.66 and 1.0), chemical disorder reduced the freezing temperature (Tg) values with a ×1/3 dependence. Cole-Cole analysis of the AC magnetic field response showed similar phenomenological parameters for the stoichiometric (x = 0) and the Y3+ doped compounds with spin glassiness, suggesting an analogous mechanism for these compounds. For the Dy3-xYxTaO7 system, in which the spin glass behaviour seems to exhibit a critical concentration, a magnetic phase diagram is proposed.
NASA Technical Reports Server (NTRS)
Fegley, B., Jr.; Post, J. E.
1985-01-01
The first detailed petrographic and mineralogical study of a Ca, Al-rich inclusion (CAI) from the Kaba CV3 chondrite is reported. This 'fine-grained' CAI contains abundant small, rounded, rimmed, spinel-rich objects which have important features in common with the spinel-rich objects in other carbonaceous and ordinary chondrites. These nodules are interpreted as fractionated distillation residues of primitive dust. However, the available data do not unambiguously rule out a condensation origin for at least some of these objects. Finally, the preservation of distinct diopside-hedenbergite rims on the spinel-rich bodies and the small grain size of many minerals in the CAI matrix material both suggest that the CAI accreted cool and had a relatively cool thermal history in the Kaba parent body.
Plantar pressure during running in subjects with chronic ankle instability.
Morrison, Katherine E; Hudson, David J; Davis, Irene S; Richards, James G; Royer, Todd D; Dierks, Tracy A; Kaminski, Thomas W
2010-11-01
It has been suggested that dynamic foot and ankle mechanics predispose individuals with CAI to repetitive episodes of the ankle ``giving way.'' Plantar pressure variations during a walking gait have been detected in those with CAI, but more dynamic conditions for analysis are needed. The purpose of this study was to evaluate plantar pressure distributions during a running gait in individuals with CAI, individuals who suffered a lateral ankle sprain, but did not develop CAI (AS), and subjects with no history of a lateral ankle sprain (CON). Forty-five subjects [15 in each group, healthy males (18) and females (27), age 18 to 45] were recruited from University communities to participate in this study. Plantar pressure distributions were analyzed on a Tekscan© plantar pressure mat at 66 frames per second during a running gait at a controlled speed. The following variables were obtained: rearfoot medial/lateral (M/L) pressure ratio at foot strike (FS) and center-of-pressure (COP) trajectory during the initial loading response (heel strike to initial peak GRF). Separate one-way ANOVA with Tukey's post-hoc were used to test for group differences. The significance level was defined as p < 0.05. The CAI group had a significantly more lateral ratio (0.97 ± 0.12) at FS when compared to the CON (1.01 ± 0.13) and AS (1.11 ± 0.13) groups. The CAI subjects had a lateral COP trajectory during the loading phase (7.97 degrees ± 11.02), while both the AS (-3.68 degrees ± 10.24) and CON groups (-6.27 degrees ± 9.86) had medial trajectories. The difference was significant between the CAI group and both the AS and CON groups (all significant {\\it p} values were less than 0.05). Our results confirm that CAI subjects have a more lateral foot positioning and loading pattern during a barefoot running gait when compared to both the CON and LAS groups. Clinicians treating patients with CAI should consider providing interventions to decrease the amount of rearfoot inversion at FS and
Impact of Erb-B Signaling on Myelin Repair in the CNS Following Virus-Induced Damage
2012-03-01
Amile-Lefond, C. and B. Jubelt. 2009. Neurologic manifestations of varicella zoster 303 virus infections. Curr Neurol Neurosci Rep 9: 430-434. 304 3...Taos, New Mexico , January 1999. . Drescher, K.M. - 10 29 Pavelko KD, McGavern DB, Drescher KM, David CS Rodriguez M. HLA-DQ8 enhances...Peptide, Taos, New Mexico , January 1999. 30 Das P, Drescher KM, Bradley DS, Rodriguez M, David CS. HLA-DR is critical for the induction of EAE, while
Thyroid associated orbitopathy
Verma, Rajesh; Gupta, Mani; Mehta, Vinod Kumar
2013-01-01
Thyroid-associated orbitopathy (TAO) is a self-limiting auto-immune condition usually associated with Grave's disease. It is characterised by ocular pain, eyelid swelling, chemosis, proptosis and keratopathy. As the mechanism for ophthamoplegia and optic neuropathy is the orbital swelling leading to mechanical restriction of ocular muscles and compression of optic nerve, one expects proptosis rather than ptosis in TAO. We describe a case of a young adult woman who presented with acute onset restriction of movement along with partial ptosis and severe diminution of vision in left eye. The MRI of orbit revealed significant swelling of recti along with signal alteration consistent with TAO. The radio-isotope thyroid scan revealed thyroiditis, and thyroid peroxidase (TPO) antibody was significantly high; hence, the diagnosis of Hashimoto thyroiditis was considered. A course of intravenous methylprednisolone followed by oral steroid was administered, which produced marked improvement in vision and extraocular movement. PMID:23737589
El-Ghamrawy, Mona Kamal; Hanna, Wagdi Maurice; Abdel-Salam, Amina; El-Sonbaty, Marwa M; Youness, Eman R; Adel, Ahmed
2014-01-01
the present study was conducted to investigate the oxidant-antioxidant status in Egyptian children with sickle cell anemia. the serum levels of total antioxidant capacity (TAO), paraoxonase (PON), vitamin E, nitrite, and malondialdehyde (MDA) were measured in 40 steady state children with homozygous sickle cell anemia (24 males and 16 females) and 20 apparently healthy age- and gender-matched controls. mean serum TAO, PON, vitamin E, and nitrite levels were significantly lower in the group with sickle cell anemia, whereas mean serum MDA was significantly higher in these children compared to controls. No significant differences in mean levels of TAO, PON, nitrite, vitamin E, and MDA were found in sickle cell anemia patients receiving hydroxyurea when compared with those not receiving hydroxyurea. A significant negative correlation between serum nitrite and the occurrence of vaso-occlusive crises (VOC) was observed (r=-0.3, p=0.04). PON level was found to be positively correlated with patients' weight and BMI (r=-0.4, p=0.01; r=-0.7, p<0.001, respectively), but not with frequency of VOC. The area under the curve of serum nitrite in predicting occurrence of VOC was 0.782, versus 0.701 for PON, and 0.650 for TAO (p=0.006). Serum MDA was not correlated with nitrite, PON, TAO, or vitamin E levels. No significant correlations were detected between serum nitrite and hemoglobin or antioxidant enzymes. children with sickle cell anemia have chronic oxidative stress that may result in increased VOC, and decreased serum nitrite may be associated with increases in VOC frequency. A novel finding in this study is the decrease in PON level in these patients, which is an interesting subject for further research. Copyright © 2014 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
Harmon, Caroline C Gillespie; Hawkins, Jan F; Li, Jianming; Connell, Sean; Miller, Margaret; Saenger, Megan; Freeman, Lynetta J
2017-05-01
OBJECTIVE To determine the effects of 3 topically applied treatments (1% silver sulfadiazine cream [SSC], triple antimicrobial ointment [TAO], and hyperosmolar nanoemulsion [HNE]) on microbial counts, exuberant granulation tissue (EGT) development, and reepithelialization of contaminated wounds at the distal aspect of the limbs of horses. ANIMALS 8 healthy adult horses. PROCEDURES A 2.5 × 2.5-cm, full-thickness, cutaneous wound was created at the dorsal aspect of each metacarpus and metatarsus (1 wound/limb/horse), covered with nonadhesive dressing, and bandaged. Wounds were inoculated with bacteria and fungi the next day. Each wound on a given horse was randomly assigned to 1 of 4 treatment groups (SSC, TAO, HNE, or no topical treatment [control]). Bandage changes, culture of wound samples, treatments, photography for wound measurements, and biopsy were performed at predetermined time points. Time (days) until wound closure, number of EGT excisions, microbial counts, and scores for selected histologic characteristics were compared among groups. RESULTS Median time to wound closure for all groups was 42 days. Time to wound closure and histologic characteristics of wound healing did not differ among groups. Least squares mean microbial counts were significantly higher for HNE-treated wounds on days 9 and 21, compared with SSC-treated and TAO-treated wounds, but not controls. Proportions of SSC-treated (7/8) or HNE-treated (5/8) wounds needing EGT excision were significantly greater than that of TAO-treated (1/8) wounds. The proportion of SSC-treated wounds with EGT excision was greater than that of controls (3/8). CONCLUSIONS AND CLINICAL RELEVANCE None of the treatments resulted in more rapid wound closure, compared with that for untreated control wounds under the study conditions. When treatment is warranted, TAO may help to limit EGT formation.
I-Xe Dating: The Time Line of Chondrule Formation and Metamorphism in LL Chondrites
NASA Technical Reports Server (NTRS)
Pravdivtseva, O. V.; Hohenberg, C. M.; Meshik, A. P.
2005-01-01
Refractory inclusions, considered to be the oldest solids formed in the solar nebula. (4567.2 0.6 Ma) [1], are common in many carbonaceous and in some ordinary and enstatite chondrites. High-precision Pb- Pb ages for CAI s and chondrules (from different meteorites) suggested that chondrule formation appeared to have started about 2 Ma later than that of CAIs [1]. However, recent 26Al/26Mg data suggest simultaneous formation of CAI s and chondrules in Allende [2]. The I-Xe ages of CAI s in Allende are about 2 Ma younger than the I-Xe ages of Allende chondrules [3] but, like all chronometers, the I-Xe system records closure time of its particular host phase. In the case of Allende CAI s, the major iodine-bearing phase is sodalite, a secondary phase presumably formed by aqueous alteration, so I-Xe reflects the post-formational processes in these objects. In chondrules the iodine host phases vary and can reflect formation and/or alteration but, to put chondrule ages on a quantative basis, some problems should first be addressed.
The Successive Contributions of Computers to Education: A Survey.
ERIC Educational Resources Information Center
Lelouche, Ruddy
1998-01-01
Shows how education has successively benefited from traditional information processing through programmed instruction and computer-assisted instruction (CAI), artificial intelligence, intelligent CAI, intelligent tutoring systems, and hypermedia techniques. Contains 29 references. (DDR)
ERIC Educational Resources Information Center
McCrary, Ronald G.
A discussion of computer software and courseware for second-language instruction outlines considerations for selecting software of various kinds and presents a list of selected computer programs. Suggestions are made for choosing text-specific software, non-text-specific software intended for language instruction, word processors intended for…
Locomotive biomechanics in persons with chronic ankle instability and lateral ankle sprain copers.
Doherty, Cailbhe; Bleakley, Chris; Hertel, Jay; Caulfield, Brian; Ryan, John; Delahunt, Eamonn
2016-07-01
To compare the locomotive biomechanics of participants with chronic ankle instability (CAI) to those of lateral ankle sprain (LAS) copers. Cross-sectional study. Twenty-eight participants with CAI and 42 LAS copers each performed 5 self-selected paced gait trials. 3-D lower extremity temporal kinematic and kinetic data were collected for these participants from 200ms pre- to 200ms post-heel strike (period 1) and from 200ms pre- to 200ms post-toe off (period 2). The CAI group displayed increased hip flexion bilaterally during period 1 compared to LAS copers. During period 2, CAI participants exhibited reduced hip extension bilaterally, increased knee flexion bilaterally and increased ankle inversion on the 'involved' limb. They also displayed a bilateral decrease in the flexor moment pattern at the knee. Considering that all of the features which distinguished CAI participants from LAS copers were also evident in our previously published research (within 2-weeks following acute first-time LAS); these findings establish a potential link between these features and long-term outcome following first-time LAS. Clinicians must be cognizant of the capacity for these movement and motor control impairments to cascade proximally from the injured joint up the kinetic chain and recognise the value that gait re-training may have in rehabilitation planning to prevent CAI. Copyright © 2015 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
Long-term outcome of pediatric renal transplantation: a single center study in Japan.
Yamada, Akio; Tashiro, Atsushi; Hiraiwa, Tomoko; Komatsu, Tomonori; Kinukawa, Tsuneo; Ueda, Norishi
2014-08-01
Little is known about the risk factors for long-term poor outcome in pediatric renal transplantation. Between 1973 and 2010, 111 renal transplants (92 living donations) were performed in 104 children (56 males, mean age, 12.5 yr) at the Social Insurance Chukyo Hospital, and followed-up for a mean period of 13.6 yr. The patient survival at 1, 5, 10, 15, 20 (living- and deceased-donor transplants), and 30 yr (living-donor transplants only) was 98.1%, 92.8%, 87.8%, 84.9%, 82.6%, and 79.3%. The graft survival at 1, 5, 10, 15, 20, and 30 yr was 92.0%, 77.3%, 58.4%, 50.8%, 38.5%, and 33.3%. The most common cause of graft loss was CAI, AR, death with functioning, recurrent primary disease, ATN, and malignancy. Donor gender, ATN, malignancy/cardiovascular events, and eras affected patient survival. AR and CAI were the risk factors for graft loss. The evolved immunosuppression protocols improved the outcome by reducing AR episodes and ATN but not CAI, suggesting CAI as the major risk factor for graft loss. CAI was correlated with AR episodes, CMV infection, and post-transplant hypertension. Strategies for preventing the risk factors for malignancy/cardiovascular events and CAI, including hypertension/infection, are crucial for better outcomes. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Koldenhoven, Rachel M; Feger, Mark A; Fraser, John J; Saliba, Susan; Hertel, Jay
2016-04-01
Lateral ankle sprains are common and can manifest into chronic ankle instability (CAI) resulting in altered gait mechanics that may lead to subsequent ankle sprains. Our purpose was to simultaneously analyse muscle activation patterns and plantar pressure distribution during walking in young adults with and without CAI. Seventeen CAI and 17 healthy subjects walked on a treadmill at 4.8 km/h. Plantar pressure measures (pressure-time integral, peak pressure, time to peak pressure, contact area, contact time) of the entire foot and nine specific foot regions and medial-lateral location of centre of pressure (COP) were measured. Surface electromyography (EMG) root mean square (RMS) amplitudes throughout the entire stride cycle and area under RMS curve for 100 ms pre-initial contact (IC) and 200 ms post-IC for anterior tibialis, peroneus longus, medial gastrocnemius, and gluteus medius were collected. The CAI group demonstrated a more lateral COP throughout the stance phase (P < 0.001 and Cohen's d > 0.9 for all 10 comparisons) and significantly increased peak pressure (P = 0.025) and pressure-time integral (P = 0.049) under the lateral forefoot. The CAI group had lower anterior tibialis RMS areas (P < 0.001) and significantly higher peroneus longus, medial gastrocnemius, and gluteus medius RMS areas during 100 ms pre-IC (P < 0.003). The CAI group had higher gluteus medius sEMG amplitudes during the final 50 % of stance and first 25% of swing (P < 0.05). The CAI group had large lateral deviations of their COP location throughout the entire stance phase and increased gluteus medius muscle activation amplitude during late stance through early swing phase. III.
Trace Element Abundances in an Unusual Hibonite-Perovskite Refractory Inclusion from Allende
NASA Technical Reports Server (NTRS)
Mane, Prajkta; Wadhwa, M.; Keller, L. P.
2013-01-01
Calcium-aluminum-rich refractory inclusions (CAIs) are thought to be the first-formed solids in the Solar protoplanetary disk and can provide information about the earliest Solar System processes (e.g., [1]). A hibonite-perovskitebearing CAI from the Allende CV3 chondrite (SHAL, [2]) contains a single of 500 micrometers hibonite grain and coarse-grained perovskite. The mineralogy and oxygen isotopic composition of this CAI shows similarities with FUN inclusions, especially HAL [2]. Here we present trace element abundances in SHAL.
Oxygen isotopic variations in the outer margins and Wark-Lovering rims of refractory inclusions
NASA Astrophysics Data System (ADS)
Simon, Justin I.; Matzel, Jennifer E. P.; Simon, Steven B.; Hutcheon, Ian D.; Ross, D. Kent; Weber, Peter K.; Grossman, Lawrence
2016-08-01
Oxygen isotopic variations across the outer margins and Wark-Lovering (WL) rims of a diverse suite of six coarse-grained Types A and B refractory inclusions from both oxidized and reduced CV3 chondrites suggest that CAIs originated from a 16O-rich protosolar gas reservoir and were later exposed to both relatively 17,18O-rich and 16O-rich reservoirs. The O-isotope profiles of CAIs can be explained by changes in the composition of gas near the protoSun or the migration of CAIs through a heterogeneous nebula. Variability within the inclusion interiors appears to have been set prior to WL rim growth. Modeling the isotopic zoning profiles as diffusion gradients between inclusion interiors and edges establishes a range of permissible time-temperature combinations for their exposure in the nebula. At mean temperatures of 1400 K, models that match the isotope gradients in the inclusions yield timescales ranging from 5 × 103 to 3 × 105 years. Assuming CAIs originated with a relatively 16O-rich (protosolar) isotopic composition, differences among the melilite interiors and the isotopic gradients in their margins imply the existence of a number of isotopically distinct reservoirs. Evidence at the edges of some CAIs for subsequent isotopic exchange may relate to the beginning of rim formation. In the WL rim layers surrounding the interiors, spinel is relatively 16O-rich but subtly distinct among different CAIs. Melilite is often relatively 16O-poor, but rare relatively 16O-rich grains also exist. Pyroxene generally exhibits intermediate O-isotope compositions and isotopic zoning. Olivine in both WL and accretionary rims, when present, is isotopically heterogeneous. The extreme isotopic heterogeneity among and within individual WL rim layers and in particular, the observed trends of outward 16O-enrichments, suggest that rims surrounding CAIs contained in CV3 chondrites, like the inclusions themselves, formed from a number of isotopically distinct gas reservoirs. Collectively
Potvin Kent, Monique; Pauzé, Elise
2018-06-01
To assess the effectiveness of the self-regulatory Canadian Children's Food and Beverage Advertising Initiative (CAI) in limiting advertising of unhealthy foods and beverages on children's preferred websites in Canada.Design/Setting/SubjectsSyndicated Internet advertising exposure data were used to identify the ten most popular websites for children (aged 2-11 years) and determine the frequency of food/beverage banner and pop-up ads on these websites from June 2015 to May 2016. Nutrition information for advertised products was collected and their nutrient content per 100 g was calculated. Nutritional quality of all food/beverage ads was assessed using the Pan American Health Organization (PAHO) and UK Nutrient Profile Models (NPM). Nutritional quality of CAI and non-CAI company ads was compared using χ 2 analyses and independent t tests. About 54 million food/beverage ads were viewed on children's preferred websites from June 2015 to May 2016. Most (93·4 %) product ads were categorized as excessive in fat, Na or free sugars as per the PAHO NPM and 73·8 % were deemed less healthy according to the UK NPM. CAI-company ads were 2·2 times more likely (OR; 99 % CI) to be excessive in at least one nutrient (2·2; 2·1, 2·2, P<0·001) and 2·5 times more likely to be deemed less healthy (2·5; 2·5, 2·5, P<0·001) than non-CAI ads. On average, CAI-company product ads also contained (mean difference; 99 % CI) more energy (141; 141·1, 141·4 kcal, P<0·001, r=0·55), sugar (18·2; 18·2, 18·2 g, P<0·001, r=0·68) and Na (70·0; 69·7, 70·0 mg, P<0·001, r=0·23) per 100 g serving than non-CAI ads. The CAI is not limiting unhealthy food and beverage advertising on children's preferred websites in Canada. Mandatory regulations are needed.
Computer-Assisted Instruction and Increased Educational Productivity
ERIC Educational Resources Information Center
Cropley, A. J.; Gross, P. F.
1973-01-01
Describes the role of computer-assisted instruction (CAI) in increasing educational productivity and equality of opportunity. Examines a number of key questions concerning the interrelationship of CAI with the traditional education structure. (Authors/WM)
Stehno-Bittel, L; Sturek, M
1992-01-01
1. We tested the hypothesis that the Ca(2+)-loaded sarcoplasmic reticulum (SR) of coronary artery smooth muscle spontaneously releases Ca2+ preferentially toward the sarcolemma to be extruded from the cell without increasing the average free myoplasmic [Ca2+] (Ca(im)) concentration. 2. The SR of bovine cells was Ca(2+)-loaded by depolarization-induced Ca2+ influx. Release (unloading) of Ca2+ from the SR during recovery from depolarization was determined by Fura-2 microfluorometry of Ca(im). The SR Ca2+ unloading was maximal following a long (14 min) recovery from depolarization, as shown by the 66% decrease in the peak caffeine-induced Ca(im) transient compared to the Ca(im) transient after a short (2 min) recovery. No increase in Ca(im) occurred during the long recovery. No unloading of the SR Ca2+ store was noted in porcine cells. 3. Approximately 80% of the outward K+ current in bovine and porcine cells was sensitive to subsarcolemmal Ca2+ (Ca(is)) concentrations. Whole-cell voltage clamp using pipette solutions with Ca2+ concentrations clamped between 0 and 1000 nM with Ca(2+)-EGTA or Ca(2+)-BAPTA buffers showed increasing K+ currents (normalized for cell membrane surface area) as a function of both membrane potential and Ca(is). Clamping of Ca(im) and Ca(is) was verified by the lack of changes in K+ current and Fura-2 ratio in response to Ca2+ influx, Ca(2+)-free external solution, or caffeine-induced Ca2+ release. At +30 to +50 mV the K+ current amplitude showed a similar sensitivity to Ca2+ as Fura-2. These data indicate that in this experimental preparation Ca(2+)-activated K+ current is a valid estimate of Ca(is). 4. Simultaneous Ca(im) and Ca(is) measurements in bovine cells which were not Ca(2+)-clamped (2 x 10(-4) M-EGTA pipette solution) showed that during the long recovery period the K+ current (reflecting Ca(is)) increased 55%, while Ca(im) did not change. 5. In quiescent bovine cells the Ca(is) was higher than Ca(im), while the higher resting Ca(is
Croy, Theodore; Saliba, Susan A; Saliba, Ethan; Anderson, Mark W; Hertel, Jay
2012-07-01
Cross-sectional. To use stress ultrasonography to measure the change in anterior talofibular ligament length during the simulated anterior drawer and ankle inversion stress tests. In approximately 30% of individuals, ankle sprains may eventually develop into chronic ankle instability (CAI) with recurrent symptoms. Individuals with CAI and those who have a history of ankle sprain (greater than 1 year prior) without chronic instability (copers) may or may not have mechanical laxity. Sixty subjects (n=60 ankles) were divided into 3 groups: 1) Control subjects without ankle injury history (n=20; mean ± SD age; 24.8 ± 4.8 years; height, 173.7 ± 9.4 cm; weight, 77.2 ± 19.5 kg), ankle sprain copers (n=20; 22.3 ± 2.9 years; 172.8 ± 11.3 cm; 72.4 ± 14.3 kg), and subjects with CAI (n=20; 23.5 ± 4.2 years; 174.6 ± 9.6 cm; 74.8 ± 17.3 kg). Ligament length change with the anterior drawer and end range ankle inversion was calculated from ultrasound images. The Foot and Ankle Ability Measure (FAAM) was used to quantify self-reported function on activities-of-daily living (ADL) and sports. The anterior drawer test resulted in length changes that were greater (F₂,₅₇=6.2, P=.004) in the CAI (mean ± SD length change, 15.6 ± 15.1%, P=.006) and the coper groups (14.0 ± 15.9%, P=.016) compared to the control group (1.3 ± 10.7%); however the length change for the CAI and coper groups were not different (P=.93). Ankle inversion similarly resulted in greater ligament length change (F₂,₅₇=6.5, P=.003) in the CAI (25.3 ± 15.5%, P=.003) and coper groups (20.2 ± 19.6%, P=.039) compared to the control group (7.4 ± 12.9%); with no difference in length change between the copers and CAI groups (P=.59). The CAI group had a lower score on the FAAM-ADL (87.4 ± 13.4%) and FAAM-Sports (74.2 ± 17.8%) when compared to the control (98.8 ± 2.9% and 98.9 ± 3.1%, P<.0001) and coper groups (99.4 ± 1.8% and 94.6 ± 8.8%, P<.0001). Stress ultrasonography identified greater
Multiscale Mass-Spring Models of Carbon Nanotube Foams
2010-09-06
Mesarovic et al., 2007). The study of thin structural foams (Gibson and Ashby, 1998) for cushioning (Zhang et al., 2009), energy dissipation ( Teo et al...compressible foam-like behavior under compressive cycling loads (Suhr et al., 2007; Teo et al., 2007; Tao et al., 2008; Deck et al., 2007; Cao et al., 2005). 2...and electrostatic interaction be- tween individual and bundles of carbon nanotubes (Suhr et al., 2007; Teo et al., 2007; Tao et al., 2008; Deck et al
Pore Topology Effects in Positron Annihilation Spectroscopy of Zeolites.
Zubiaga, Asier; Warringham, Robbie; Mitchell, Sharon; Gerchow, Lars; Cooke, David; Crivelli, Paolo; Pérez-Ramírez, Javier
2017-03-03
Positron annihilation spectroscopy (PAS) is a powerful method to study the size and connectivity of pores in zeolites. The lifetime of positronium within the host material is commonly described by the Tao-Eldrup model. However, one of its largest limitations arises from the simple geometries considered for the shape of the pores, which cannot describe accurately the complex topologies in zeolites. Here, an atomic model that combines the Tao potential with the crystallographic structure is introduced to calculate the distribution and lifetime of Ps intrinsic to a given framework. A parametrization of the model is undertaken for a set of widely applied zeolite framework types (*BEA, FAU, FER, MFI, MOR, UTL), before extending the model to all known structures. The results are compared to structural and topological descriptors, and to the Tao-Eldrup model adapted for zeolites, demonstrating the intricate dependence of the lifetime on the pore architecture. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Mahdavi, Hamed; Prasad, Vinay; Liu, Yang; Ulrich, Ania C
2015-01-01
In this study, the biodegradation of total acid-extractable organics (TAOs), commonly called naphthenic acids (NAs), was investigated. An indigenous microbial culture containing algae and bacteria was taken from the surface of a tailings pond and incubated over the course of 120days. The influence of light, oxygen and the presence of indigenous algae and bacteria, and a diatom (Navicula pelliculosa) on the TAO removal rate were elucidated. The highest biodegradation rate was observed with bacteria growth only (without light exposure) with a half-life (t(1/2)) of 203days. The algae-bacteria consortium enhanced the detoxification process, however, bacterial biomass played the main role in toxicity reduction. Principal component analysis (PCA) conducted on FT-IR spectra, identified functional groups and bonds (representing potential markers for biotransformation of TAOs) as follows: hydroxyl, carboxyl and amide groups along with CH, arylH, arylOH and NH bonds. Copyright © 2015 Elsevier Ltd. All rights reserved.
NASA Astrophysics Data System (ADS)
Schönbächler, M.; Lai, Y.-J.; Henshall, T.; Fehr, M. A.; Cook, D. L.; Bullock, E. S.
2017-07-01
New CAI data confirm the homogeneous distribution of the short-lived p-process isotope 92Nb in the early solar system with the exception of CAIs with group II REE pattern that show increased 92Nb abundances.
Strong, Stacey A; Hirji, Nashila; Quartilho, Ana; Kalitzeos, Angelos; Michaelides, Michel
2018-04-29
Carbonic anhydrase inhibitors (CAIs) are frequently used as an initial step to treat retinitis pigmentosa-associated cystoid macular oedema (RP-CMO). Interestingly, it has been postulated that CAIs might reduce outer nuclear layer (ONL) fluid more effectively than inner nuclear layer (INL) fluid due to better access to retinal pigment epithelium basolateral membrane than neurosensory retina. This retrospective cohort study explores if an association between spatial distribution of cystoid spaces in RP-CMO and CAI response exists. Two independent graders reviewed pretreatment and post-treatment optical coherence tomography (OCT) images of 25 patients (43 eyes) initiated on topical and/or oral CAIs between January 2013 and December 2014. Documentation included the presence/absence of fluid (and layer(s) involved), external limiting membrane, epiretinal membrane (ERM), vitreomacular adhesion/traction, lamellar/full-thickness macular hole and central macular thickness (CMT)/volume. INL fluid was found in all study eyes. All 13 'responders' (at least 11% reduction of CMT after treatment) demonstrated pretreatment ONL fluid. In seven patients (four responders and three non-responders), complete clearance of ONL fluid was achieved despite persistence of INL fluid. ERM presence was similar in responders and non-responders. In this study, INL fluid was found to be the most common spatial distribution of RP-CMO. However, patients who were classed as a 'responder' to CAI treatment all demonstrated coexisting ONL fluid on their pretreatment OCT scans. This may be explained by CAIs having better access to retinal pigment epithelium basolateral membrane than neurosensory retina. Our study also suggests a minimal impact on response to CAIs by ERM. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Developing a Framework for Ankle Function: A Delphi Study
Snyder, Kelli R.; Evans, Todd A.; Neibert, Peter J.
2014-01-01
Context: Addressing clinical outcomes is paramount to providing effective health care, yet there is no consensus regarding the appropriate outcomes to address after ankle injuries. Compounding the problem is the repetitive nature of lateral ankle sprains, referred to as functional (FAI) or chronic (CAI) ankle instability. Although they are commonly used terms in practice and research, FAI and CAI are inconsistently defined and assessed. Objective: To establish definitions of a healthy/normal/noninjured ankle, FAI, and CAI, as well as their characteristics and assessment techniques. Design: Delphi study. Setting: Telephone interviews and electronic surveys. Patients or Other Participants: Sixteen experts representing the fields of ankle function and treatment, ankle research, and outcomes assessment and research were selected as panelists. Data Collection and Analysis: A telephone interview produced feedback regarding the definition of, functional characteristics of, and assessment techniques for a healthy/normal/noninjured ankle, an unhealthy/acutely injured ankle, and FAI/CAI. Those data were compiled, reduced, and returned through electronic surveys and were either included by reaching consensus (80% agreement) or excluded. Results: The definitions of a healthy/normal/noninjured ankle and FAI reached consensus. Experts did not agree on a definition of CAI. Eleven functional characteristics of a healthy/normal/noninjured ankle, 32 functional characteristics of an unhealthy/acutely injured ankle, and 13 characteristics of FAI were agreed upon. Conclusions: Although a consensus was reached regarding the definitions and functional characteristics of a healthy/normal/noninjured ankle and FAI, the experts could only agree on 1 characteristic to include in the FAI definition. Several experts did, however, provide additional comments that reinforced the differences in the interpretation of those concepts. Although the experts could not agree on the definition of CAI, its
Developing a framework for ankle function: a delphi study.
Snyder, Kelli R; Evans, Todd A; Neibert, Peter J
2014-01-01
Addressing clinical outcomes is paramount to providing effective health care, yet there is no consensus regarding the appropriate outcomes to address after ankle injuries. Compounding the problem is the repetitive nature of lateral ankle sprains, referred to as functional (FAI) or chronic (CAI) ankle instability. Although they are commonly used terms in practice and research, FAI and CAI are inconsistently defined and assessed. To establish definitions of a healthy/normal/noninjured ankle, FAI, and CAI, as well as their characteristics and assessment techniques. Delphi study. Telephone interviews and electronic surveys. Sixteen experts representing the fields of ankle function and treatment, ankle research, and outcomes assessment and research were selected as panelists. A telephone interview produced feedback regarding the definition of, functional characteristics of, and assessment techniques for a healthy/normal/noninjured ankle, an unhealthy/acutely injured ankle, and FAI/CAI. Those data were compiled, reduced, and returned through electronic surveys and were either included by reaching consensus (80% agreement) or excluded. The definitions of a healthy/normal/noninjured ankle and FAI reached consensus. Experts did not agree on a definition of CAI. Eleven functional characteristics of a healthy/normal/noninjured ankle, 32 functional characteristics of an unhealthy/acutely injured ankle, and 13 characteristics of FAI were agreed upon. Although a consensus was reached regarding the definitions and functional characteristics of a healthy/normal/noninjured ankle and FAI, the experts could only agree on 1 characteristic to include in the FAI definition. Several experts did, however, provide additional comments that reinforced the differences in the interpretation of those concepts. Although the experts could not agree on the definition of CAI, its characteristics, or the preferred use of the terms FAI and CAI, our findings provide progress toward establishing
Nucleosynthetic Heterogeneity Controls Vanadium Isotope Variations in Bulk Chondrites
NASA Technical Reports Server (NTRS)
Nielsen, S. G.; Righter, K.; Wu, F.; Owens, J. D.; Prytulak, J.; Burton, K.; Parkinson, I.; Davis, D.
2018-01-01
The vanadium (V) isotope composition of early solar system materials have been hypothesized to be sensitive to high energy irradiation that originated from the young Sun. Vanadium has two isotopes with masses 50 and 51 that have (51)V/(50)V ratio of approximately 410. High energy irradiation produces (50)V from various target isotopes of Ti, Cr and Fe, which would result in light V isotope compositions (expressed as delta (51)V in per mille = 1000 x (((51)V/(50)V(sub sample)/(51)V/(50)V(sub AlfaAesar)) - 1)) relative to a presumably chondritic starting composition. Recently published V isotope data for calcium aluminium inclusions (CAIs) has revealed some very negative values relative to chondrites (by almost -4 per mille) that were indeed interpreted to reflect irradiation processes despite the fact that the studied CAIs all exhibited significant initial abundances of (10)Be, while only a few CAIs displayed light V isotope compositions. It is difficult to relate V isotope variations directly to a singular process because V only possesses two isotopes. Therefore, V isotope variations can principally be produced both mass dependent and independent processes. Mass dependent kinetic stable isotope fractionation is common in CAIs for refractory elements due to partial condensation/evaporation processes. The element strontium (Sr) has an almost identical condensation temperature to V and studies of stable Sr isotope compositions in CAIs reveal both heavy and light values relative to chondrites of several permil. These variations are similar in magnitude to those reported for V isotopes in CAIs, which suggests it is possible that some of the V isotope variation in CAIs could be due to kinetic stable isotope fractionation during condensation/evaporation processes.
Maksut, Jessica L.; Eaton, Lisa A.; Siembida, Elizabeth J.; Driffin, Daniel D.; Baldwin, Robert
2016-01-01
Background In the United States, rates of human immunodeficiency virus (HIV) infection are highest among Black men who have sex with men (BMSM). Prior research indicates that younger BMSM in particular (i.e., BMSM 29 years of age and younger) are most at risk for HIV infection and that HIV incidence in this subpopulation has risen in recent years. It remains unclear, however, why younger BMSM, relative to BMSM 30 years of age and older, are at increased risk for HIV infection. Methods For the current study, we surveyed 450 BMSM located in the Atlanta, GA metropolitan and surrounding areas. We assessed BMSM’s depressive symptoms, substance use during sex, psychosocial risk factors (i.e., HIV risk perceptions, condom use self-efficacy, internalized homophobia, and perceived HIV stigmatization), and sexual risk taking (i.e., condomless anal intercourse [CAI]). Results We found that younger BMSM (YBMSM) and older BMSM (OBMSM) differed with respect to factors associated with CAI. In multivariable models, alcohol use before or during sex, lower educational attainment, and sexual orientation (i.e., bisexual sexual orientation) were significantly associated with increased CAI for YBMSM, while HIV risk perceptions and internalized homophobia were significantly, negatively associated with CAI among OBMSM. Discussion Rates of engaging in CAI were similar across the two age cohorts; however, factors related to CAI varied by these two groups. Findings emphasize the need to consider targeted interventions for different generational cohorts of BMSM. PMID:27001255
Testing space weather connections in the solar system
NASA Astrophysics Data System (ADS)
Grison, B.; Souček, J.; Krupař, V.; Píša, D.; Santolík, O.; Taubenschuss, U.; Němec, F.
2017-09-01
This study aims at testing and validating tools for prediction of the impact of solar events in the vicinity of inner and outer solar system planets using in-situ spacecraft data (primarily MESSENGER, STEREO and ACE, but also VEX and Cassini), remote Jovian observations (Hubble telescope, Nançay decametric array), existing catalogues (HELCATS and Tao et al. (2005)) and the tested propagating models (the ICME radial propagation tool of the CDPP and the 1-D MHD code propagation model presented in Tao et al. (2005)).
2006-12-01
T T Thrust V V Speed (Velocity) in general VA VA Speed of Advance of propeller wQ WQ Taylor Wake Fraction (torque identity) wl- WT Taylor Wake...Wasp, LHD 1 6 $45 M Tarawa, LHA 1 5 $18 M Whidbey Island / Harpers Ferry, 12 $ 24 M LSD 41 /LSD 49 (C) Fleet Auxiliary Force Henry J Kaiser, TAO 187 16...savings are associated with the TAO 187 class. Table 2 shows some general characteristics of these selected U.S. Navy ship classes. The type of prime
Does adaptation to vertebrate codon usage relate to flavivirus emergence potential?
Freire, Caio César de Melo
2018-01-01
Codon adaptation index (CAI) is a measure of synonymous codon usage biases given a usage reference. Through mutation, selection, and drift, viruses can optimize their replication efficiency and produce more offspring, which could increase the chance of secondary transmission. To evaluate how higher CAI towards the host has been associated with higher viral titers, we explored temporal trends of several historic and extensively sequenced zoonotic flaviviruses and relationships within the genus itself. To showcase evolutionary and epidemiological relationships associated with silent, adaptive synonymous changes of viruses, we used codon usage tables from human housekeeping and antiviral immune genes, as well as tables from arthropod vectors and vertebrate species involved in the flavivirus maintenance cycle. We argue that temporal trends of CAI changes could lead to a better understanding of zoonotic emergences, evolutionary dynamics, and host adaptation. CAI appears to help illustrate historically relevant trends of well-characterized viruses, in different viral species and genetic diversity within a single species. CAI can be a useful tool together with in vivo and in vitro kinetics, phylodynamics, and additional functional genomics studies to better understand species trafficking and viral emergence in a new host. PMID:29385205
You, Ji H; Kang, Purum; Min, Sun Seek; Seol, Geun Hee
2013-04-01
In this study, we compared the effect of the essential oil of Citrus bergamia Risso [bergamot, bergamot essential oil (BEO)] on the intracellular Ca levels in vascular endothelial (EA) and mouse vascular smooth muscle (MOVAS) cells, using the fura-2 fluorescence technique. BEO caused an initial transient increase in intracellular Ca concentration ([Ca]i) in EA cells, followed by a decrease, whereas it induced a sustained increase in [Ca]i in MOVAS cells. Linalyl acetate (LA) as a major component of BEO-induced [Ca]i mobilization was similar to BEO in EA cells. The increase of [Ca]i by LA was higher in EA cells than in MOVAS cells. [Ca]i rise induced by extracellular Ca application was significantly blocked by BEO or LA in EA cells but not in MOVAS cells, suggesting that BEO and LA block Ca influx in EA cells. The present results suggest that BEO and LA differentially modulate intracellular Ca levels in vascular endothelial and smooth muscle cells. In addition, blockade of Ca influx by BEO and LA in EA cells may explain the protective effects of BEO on endothelial dysfunction associated with cardiovascular disease.
Effectiveness of Using Computer-Assisted Supplementary Instruction for Teaching the Mole Concept
NASA Astrophysics Data System (ADS)
Yalçinalp, Serpil; Geban, Ömer; Özkan, Ilker
This study examined the effect of computer-assisted instruction (CAI), used as a problem-solving supplement to classroom instruction, on students' understanding of chemical formulas and mole concept, their attitudes toward chemistry subjects, and CAI. The objective was to assess the effectiveness of CAI over recitation hours when both teaching methods were used as a supplement to the traditional chemistry instruction. We randomly selected two classes in a secondary school. Each teaching strategy was randomly assigned to one class. The experimental group received supplementary instruction delivered via CAI, while the control group received similar instruction through recitation hours. The data were analyzed using two-way analysis of variance and t-test. It was found that the students who used the CAI accompanied with lectures scored significantly higher than those who attended recitation hours, in terms of school subject achievement in chemistry and attitudes toward chemistry subjects. In addition, there was a significant improvement in the attitudes of students in the experimental group toward the use of computers in a chemistry course. There was no significant difference between the performances of females versus males in each treatment group.Received: 26 April 1994; Revised: 6 April 1995;
Compression After Impact on Honeycomb Core Sandwich Panels With Thin Facesheets. Part 1; Experiments
NASA Technical Reports Server (NTRS)
McQuigg, Thomas D.; Kapania, Rakesh K.; Scotti, Stephen J.; Walker, Sandra P.
2012-01-01
A two part research study has been completed on the topic of compression after impact (CAI) of thin facesheet honeycomb core sandwich panels. The research has focused on both experiments and analysis in an effort to establish and validate a new understanding of the damage tolerance of these materials. Part one, the subject of the current paper, is focused on the experimental testing. Of interest are sandwich panels, with aerospace applications, which consist of very thin, woven S2-fiberglass (with MTM45-1 epoxy) facesheets adhered to a Nomex honeycomb core. Two sets of specimens, which were identical with the exception of the density of the honeycomb core, were tested. Static indentation and low velocity impact using a drop tower are used to study damage formation in these materials. A series of highly instrumented CAI tests was then completed. New techniques used to observe CAI response and failure include high speed video photography, as well as digital image correlation (DIC) for full-field deformation measurement. Two CAI failure modes, indentation propagation, and crack propagation, were observed. From the results, it can be concluded that the CAI failure mode of these panels depends solely on the honeycomb core density.
Normalization of Impact Energy by Laminate Thickness for Compression After Impact Testing
NASA Technical Reports Server (NTRS)
Nettles, A. T.; Hromisin, S. M.
2013-01-01
The amount of impact energy used to damage a composite laminate is a critical parameter when assessing residual strength properties. The compression after impact (CAI) strength of impacted laminates is dependent upon how thick the laminate is and this has traditionally been accounted for by normalizing (dividing) the impact energy by the laminate's thickness. However, when comparing CAI strength values for a given lay-up sequence and fiber/resin system, dividing the impact energy by the specimen thickness has been noted by the author to give higher CAI strength values for thicker laminates. A study was thus undertaken to assess the comparability of CAI strength data by normalizing the impact energy by the specimen thickness raised to a power to account for the higher strength of thicker laminates. One set of data from the literature and two generated in this study were analyzed by dividing the impact energy by the specimen thickness to the 1, 1.5, 2, and 2.5 powers. Results show that as laminate thickness and damage severity decreased, the value which the laminate thickness needs to be raised to in order to yield more comparable CAI data increases.
Psychological outcomes and gender-related development in complete androgen insensitivity syndrome.
Hines, Melissa; Ahmed, S Faisal; Hughes, Ieuan A
2003-04-01
We evaluated psychological outcomes and gender development in 22 women with complete androgen insensitivity syndrome (CAIS). Participants were recruited through a medical database (n = 10) or through a patient support group (n = 12). Controls included 14 males and 33 females, of whom 22 were matched to women with CAIS for age, race, and sex-of-rearing. Outcome measures included quality of life (self-esteem and psychological general well-being), gender-related psychological characteristics (gender identity, sexual orientation, and gender role behavior in childhood and adulthood), marital status, personality traits that show sex differences, and hand preferences. Women recruited through the database versus the support group did not differ systematically, and there were no statistically significant differences between the 22 women with CAIS and the matched controls for any psychological outcome. These findings argue against the need for two X chromosomes or ovaries to determine feminine-typical psychological development in humans and reinforce the important role of the androgen receptor in influencing masculine-typical psychological development. They also suggest that psychological outcomes in women with CAIS are similar to those in other women. However, additional attention to more detailed aspects of psychological well-being in CAIS is needed.
Feger, Mark A.; Hertel, Jay
2016-01-01
Lateral ankle sprains (LAS) and chronic ankle instability (CAI) are common musculoskeletal injuries that are a result of inversion injury during sport. The midfoot and forefoot is frequently injured during a LAS, is often overlooked during clinical examination, and maybe contributory to the development of CAI. The purpose of part two of this clinical commentary and current concept review is to increase clinician's awareness of the contribution of midfoot and forefoot impairment to functional limitation and disability of individuals who experience LAS and CAI and to facilitate future research in this area. The importance of multisegmented foot and ankle assessment from a clinical and research perspective is stressed. Select physical assessment and manual therapeutic techniques are presented to assist the clinician in examination and treatment of the ankle-foot complex in patients with LAS and CAI. PMID:27999731
Kelly, Sharon M.; O'Grady, Kevin E.; Schwartz, Robert P.; Peterson, James A.; Wilson, Monique E.; Brown, Barry S.
2010-01-01
This study was conducted to determine the psychometric properties of a measure of social support, the Community Assessment Inventory (CAI), and to examine the role of social support in recovery. The CAI and the Addiction Severity Index (ASI) were administered to 196 opioid-dependent adults in (n = 135) or out of methadone treatment (n = 61) in Baltimore, Maryland between 2004 and 2006. Baseline CAI scale scores indicated a generally high level of internal consistency (α scores). Pearson correlations showed that the scales were stable and had good discriminant validity with the ASI composite scores. One-way analysis of variance indicated that in-treatment participants reported significantly more support at baseline than out-of-treatment participants. This study's findings indicate the CAI may be a useful measure of social support and that such support is an important factor in treatment entry. PMID:20391269
Computer-assisted instruction in curricula of physical therapist assistants.
Thompson, E C
1987-08-01
This article compares the effectiveness of computer-assisted instruction (CAI) with written, programmed instruction between two groups of physical therapist assistant students. No significant difference in the amount of material learned or retained after completion of testing using either CAI or a written, programmed text was found in this group of 16 subjects. Learning style or attitude about computers did not correlate strongly with performance after the CAI. Findings suggest that more research is needed to support decisions related to fiscal allotments for computer use in college curricula.
The impact of common APSE interface set specifications on space station information systems
NASA Technical Reports Server (NTRS)
Diaz-Herrera, Jorge L.; Sibley, Edgar H.
1986-01-01
Certain types of software facilities are needed in a Space Station Information Systems Environment; the Common APSE (Ada Program Support Environment) Interface Set (CAIS) was proposed as a means of satisfying them. The reasonableness of this is discussed by examining the current CAIS, considering the changes due to the latest Requirements and Criteria (RAC) document, and postulating the effects on the CAIS 2.0. Finally, a few additional comments are made on the problems inherent in the Ada language itself, especially on its deficiencies when used for implementing large distributed processing and data base applications.
Dominant behaviours in the expression of human carbonic anhydrase hCA I activity.
Abdelrahim, M Yahia M; Tanc, Muhammet; Winum, Jean-Yves; Supuran, Claudiu T; Barboiu, Mihail
2014-07-28
Here we describe the screening via Dynamic Deconvolution of DCLs of inhibitors (CAIs) and activators (CAAs) of hCA I. The inhibitory effects dominate over the activating ones, while the CAAs may be identified in the absence of CAIs.
Lu, Yung-Hsiu; Cheng, Li-Mei; Huang, Yu-Hsiu; Lo, Ming-Yu; Wu, Tina Jui-Ting; Lin, Hsiang-Yu; Hsu, Ting-Rong; Niu, Dau-Ming
2015-12-01
Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load. However, the amount of methionine required for a loading test is non-physiological and is never reached with regular feeding. Therefore, CBS carriers do not seem to be at an increased risk of cardiovascular diseases. However, the risk of cardiovascular diseases of CBS carriers with folate deficiency has not been studied. We recently found an extraordinarily high carrier rate (1/7.78) of a novel CBS mutation (p.D47E, c.T141A) in an Austronesian Taiwanese Tao tribe who live in a geographic area with folate deficiency. We evaluated if the CBS carriers tend to have higher fasting serum tHcy concentrations than non-carriers in presence of folate deficiency. The serum tHcy and folate levels before and after folate replacement were measured in 48 adult Tao carriers, 40 age-matched Tao non-carriers and 40 age-matched Han Taiwanese controls. The serum tHcy level of the Tao CBS carriers (17.9 ± 3.8 μmol/l) was significantly higher than in Tao non-carriers (15.7 ± 3.5 μmol/l; p < 0.008) and Taiwanese controls (11.8 ± 2.9 μmol/l; p < 0.001). Furthermore, a high prevalence of folate deficiency in the Tao compared with the Taiwanese controls (4.9 ± 1.8 ng/ml vs. 10.6 ± 5.5 ng/ml; p < 0.001) was also noted. Of note, the difference in tHcy levels between the carriers and non-carriers was eliminated by folate supplementation. (carriers:13.65 ± 2.13 μmol/l; non-carriers:12.39 ± 3.25 μmol/l, p = 0.321). CBS carriers tend to have a higher tHcy level in the presence of folate deficiency than non-carriers. Although many reports have indicated that CBS carriers are not associated with cardiovascular disease, the risk for CBS carriers with folate deficiency has not been well studied. Owing to a significantly elevated level of fasting tHcy without methionine loading, it is important to evaluate the
TEM study of compact Type A Ca,Al-rich inclusions from CV3 chondrites: Clues to their origin
NASA Astrophysics Data System (ADS)
Greshake, Ansgar; Bischoff, Addi; Putnis, Andrew
1998-01-01
A transmission electron microscope study of three coarse-grained Type A Ca,Al-rich inclusions (CAIs) from Allende, Acfer 082 and Acfer 086 (all CV3 chondrites) was performed in order to decipher their origin and effects of possible metamorphism. The constituent minerals of the CAIs are found to exhibit very similar microstructural characteristics in each of the inclusions studied. In general, the minerals show a well-developed equilibrium texture with typical 120 triple junctions. Melilites are clearly considerably strained and characterized by high dislocation densities up to 3 x 1011 cm-2. The dislocations have Burgers vectors of [001], [110] or [011] and often form subgrain boundaries subparallel {100}. Melilite in the Allende CAI additionally contains thin amorphous lamellae mostly oriented parallel to {001}. Fassaite (Al-Ti-diopside) is almost featureless even on the TEM scale. Only a few sub-planar dislocation walls composed of dislocations with Burgers vectors [001] and 1/2 [110] were detected. Although enclosed within the highly strained melilites, the euhedral spinels contain only low dislocation densities (<2 x 104 cm-2). In the Allende CAI, spinels were found twinned on {111}. Perovskite is also characterized by a low number of linear lattice defects. All grains possess orthorhombic symmetry and are commonly twinned according to a 90 rotation around [101]. Many crystals exhibit typical domain structures as well as curved twin walls where two orthogonal sets intersect. In addition to the mineral phases described above, tiny inclusions of the simple oxides CaO and TiO2 were found within melilite (CaO), spinel (CaO, TiO2) and perovskite (CaO, TiO2). Based on these observations it is assumed that at the beginning of the formation of the CAIs a condensed solid precursor was present. Euhedral spinels poikilitically enclosed within melilites suggest that this solid aggregate was then molten. If the pure oxides represent relict condensates, their presence proves
Oxygen isotopic variations in the outer margins and Wark–Lovering rims of refractory inclusions
Simon, Justin I.; Matzel, Jennifer E. P.; Simon, Steven B.; ...
2016-05-02
Oxygen isotopic variations across the outer margins and Wark–Lovering (WL) rims of a diverse suite of six coarse-grained Types A and B refractory inclusions from both oxidized and reduced CV3 chondrites suggest that CAIs originated from a 16O-rich protosolar gas reservoir and were later exposed to both relatively 17,18O-rich and 16O-rich reservoirs. The O-isotope profiles of CAIs can be explained by changes in the composition of gas near the protoSun or the migration of CAIs through a heterogeneous nebula. Variability within the inclusion interiors appears to have been set prior to WL rim growth. Modeling the isotopic zoning profiles asmore » diffusion gradients between inclusion interiors and edges establishes a range of permissible time–temperature combinations for their exposure in the nebula. At mean temperatures of 1400 K, models that match the isotope gradients in the inclusions yield timescales ranging from 5 × 10 3 to 3 × 10 5 years. Assuming CAIs originated with a relatively 16O-rich (protosolar) isotopic composition, differences among the melilite interiors and the isotopic gradients in their margins imply the existence of a number of isotopically distinct reservoirs. In addition, evidence at the edges of some CAIs for subsequent isotopic exchange may relate to the beginning of rim formation. In the WL rim layers surrounding the interiors, spinel is relatively 16O-rich but subtly distinct among different CAIs. Melilite is often relatively 16O-poor, but rare relatively 16O-rich grains also exist. Pyroxene generally exhibits intermediate O-isotope compositions and isotopic zoning. Olivine in both WL and accretionary rims, when present, is isotopically heterogeneous. The extreme isotopic heterogeneity among and within individual WL rim layers and in particular, the observed trends of outward 16O-enrichments, suggest that rims surrounding CAIs contained in CV3 chondrites, like the inclusions themselves, formed from a number of isotopically distinct
Chronic ankle instability and corticomotor excitability of the fibularis longus muscle.
Pietrosimone, Brian G; Gribble, Phillip A
2012-01-01
Neuromuscular deficits are common in people with chronic ankle instability (CAI). Corticomotor pathways are very influential in the production of voluntary muscle function, yet these pathways have not been evaluated in people with CAI. To determine if corticomotor excitability of the fibularis longus (FL) differs between individuals with unilateral CAI and matched control participants without CAI. Case-control study. Laboratory. Patients or Other Participants: Ten people with CAI (4 men, 6 women; age = 21.2 ± 1.23 years, height = 175.13 ± 9.7 cm, mass = 77.1 ± 13.58 kg) and 10 people without CAI (4 men, ± women; age = 21.2 ± 2.3 years; height = 172.34 ± 8.86 cm, mass = 73.4 ± 7.15 kg) volunteered for this study. Transcranial magnetic stimulation was performed over the motor cortex on neurons corresponding with the FL. All testing was performed with the participant in a seated position with a slightly flexed knee joint and the ankle secured in 10 8 of plantar flexion. The resting motor threshold (RMT), which was expressed as a percentage of 2 T, was considered the lowest amount of magnetic energy that would induce an FL motor evoked potential equal to or greater than 20 l V, as measured with surface electromyography, on 7 consecutive stimuli. In addition, the Functional Ankle Disability Index (FADI) and FADI Sport were used to assess self-reported function. Higher RMTs were found in the injured and uninjured FL of the CAI group (60.8% ± 8.4% and 59.1% ± 8.99%, respectively) than the healthy group (52.8% ± 8.56% and 52% ± 7.0%, respectively; F(1,18) = 4.92, P = .04). No leg x group interactions (F(1,18) = 0.1, P = .76) or between-legs differences (F(1,18) = 0.74, P = .40) were found. A moderate negative correlation was found between RMT and FADI (r = 0.4, P = .04) and FADI Sport (r = 0.44, P = .03), suggesting that higher RMT is related to lower self-reported function. Higher bilateral RMTs may indicate deficits in FL corticomotor excitability in people
NASA Astrophysics Data System (ADS)
Han, Jangmi; Brearley, Adrian J.
2017-03-01
We have studied four melilite-rich calcium-aluminum-rich inclusions (CAIs) from the Allan Hills A77307 CO3.0 chondrite using transmission electron microscopy with the focused ion beam sample preparation technique. This type of CAI represents one of the dominant types of refractory inclusions in CO3 chondrites. Individual melilite-rich CAIs 04-07 record complex formational histories involving high-temperature gas-solid condensation that occurred under both equilibrium and disequilibrium conditions. CAI 04 contains two texturally- and compositionally-distinct occurrences of perovskite: fine-grained perovskite within a melilite-rich core and aggregates of perovskite grains that surround the core. The perovskite in the core was probably involved in a disequilibrium reaction with early equilibrium condensates (e.g., melilite and spinel) and a nebular gas to form Al-Ti-rich diopside, followed by a later condensation of the perovskite aggregates under equilibrium conditions. CAI 05 has a compact melilite-rich core surrounded by a porous mantle, and likely formed by at least two different condensation events under equilibrium and disequilibrium conditions. In CAI 06, complex intergrowth layers of spinel and diopside surrounding a melilite-rich core indicate disequilibrium reaction of spinel and melilite with a nebular gas to form Al-Ti-rich diopside following core formation by equilibrium condensation. CAI 07 is dominated by melilite with a narrow compositional range and equilibrated textures, suggesting its formation by equilibrium condensation over a limited temperature range. Collectively, we infer that the melilite-rich inclusions formed by a generalized sequence of high-temperature gas-solid condensation that involved: (1) formation of CAI cores by aggregation of primary equilibrium condensates (i.e., perovskite, spinel, and melilite), (2) back-reactions of the primary core minerals with a nebular gas under disequilibrium conditions, forming diopside that evolves in
An Evaluation of Computer-Aided Instruction in an Introductory Biostatistics Course.
ERIC Educational Resources Information Center
Forsythe, Alan B.; Freed, James R.
1979-01-01
Evaluates the effectiveness of computer assisted instruction for teaching biostatistics to first year students at the UCLA School of Dentistry. Results do not demonstrate the superiority of CAI but do suggest that CAI compares favorably to conventional lecture and programed instruction methods. (RAO)
Framework for Computer Assisted Instruction Courseware: A Case Study.
ERIC Educational Resources Information Center
Betlach, Judith A.
1987-01-01
Systematically investigates, defines, and organizes variables related to production of internally designed and implemented computer assisted instruction (CAI) courseware: special needs of users; costs; identification and definition of realistic training needs; CAI definition and design methodology; hardware and software requirements; and general…
Computer-assisted instruction: a library service for the community teaching hospital.
McCorkel, J; Cook, V
1986-04-01
This paper reports on five years of experience with computer-assisted instruction (CAI) at Winthrop-University Hospital, a major affiliate of the SUNY at Stony Brook School of Medicine. It compares CAI programs available from Ohio State University and Massachusetts General Hospital (accessed by telephone and modem), and software packages purchased from the Health Sciences Consortium (MED-CAPS) and Scientific American (DISCOTEST). The comparison documents one library's experience of the cost of these programs and the use made of them by medical students, house staff, and attending physicians. It describes the space allocated for necessary equipment, as well as the marketing of CAI. Finally, in view of the decision of the National Board of Medical Examiners to administer the Part III examination on computer (the so-called CBX) starting in 1988, the paper speculates on the future importance of CAI in the community teaching hospital.
Microstructural Constraints on the Formation History of Hibonite in Refractory Inclusions
NASA Technical Reports Server (NTRS)
Han, J.; Koop, L.; Keller, L. P.; Davis, A. M.
2017-01-01
Hibonite is a primary refractory phase occurring in many Ca-Al-rich inclusions (CAIs), typically with spinel and perovskite [1]. Previous mi-crostructural studies of hibonite in CAIs revealed the presence of numerous stacking defects along the (001) plane and correlated non-stoichiometry in hibonite [2,3]. These features are interpreted as complex inter-growths of stoichiometric and Ca-deficient hibonites, as shown by experimental studies of reaction-sintered CaO-Al2O3 compounds [4]. Here, we extend our transmission electron microscope (TEM) studies to hibonite-bearing CAIs in CM chondrites that have been well characterized isotopically [5-7]. In addition, we have undertaken a series of anneal-ing experiments to explore the effect of minor elements (Mg and Ti) on the microstucure of hibonite [8,9,this study]. The results of these experiments are being applied to hibonite in CAIs in order to better understand its formation conditions.
Figueredo, V M; Brandes, R; Weiner, M W; Massie, B M; Camacho, S A
1992-01-01
Coronary artery stenosis or occlusion results in reduced coronary flow and myocardial contractile depression. At severe flow reductions, increased inorganic phosphate (Pi) and intracellular acidosis clearly play a role in contractile depression. However, during milder flow reductions the mechanism(s) underlying contractile depression are less clear. Previous perfused heart studies demonstrated no change of Pi or pH during mild flow reductions, suggesting that changes of intravascular pressure (garden hose effect) may be the mediator of this contractile depression. Others have reported conflicting results regarding another possible mediator of contractility, the cytosolic free calcium (Cai). To examine the respective roles of Cai, Pi, pH, and vascular pressure in regulating contractility during mild flow reductions, Indo-1 calcium fluorescence and 31P magnetic resonance spectroscopy measurements were performed on Langendorff-perfused rat hearts. Cai and diastolic calcium levels did not change during flow reductions to 50% of control. Pi demonstrated a close relationship with developed pressure and significantly increased from 2.5 +/- 0.3 to 4.2 +/- 0.4 mumol/g dry weight during a 25% flow reduction. pH was unchanged until a 50% flow reduction. Increasing vascular pressure to superphysiological levels resulted in further increases of developed pressure, with no change in Cai. These findings are consistent with the hypothesis that during mild coronary flow reductions, contractile depression is mediated by an altered relationship between Cai and pressure, rather than by decreased Cai. Furthermore, increased Pi and decreased intravascular pressure may be responsible for this altered calcium-pressure relationship during mild coronary flow reductions. PMID:1430205
Khorashad, Behzad S; Roshan, Ghasem M; Reid, Alistair G; Aghili, Zahra; Hiradfar, Mehran; Afkhamizadeh, Mozhgan; Talaei, Ali; Aarabi, Azadeh; Ghaemi, Nosrat; Taghehchian, Negin; Saberi, Hedieh; Farahi, Nazanin; Abbaszadegan, Mohammad Reza
2017-01-01
To report sexual orientation, relationship status and medical history of Iranian people with Differences of Sex Development (DSD) who were raised female. Our participants consisted of nineteen 46,XY individuals with Complete Androgen Insensitivity Syndrome (CAIS) and eighteen 46,XX individuals with Congenital Adrenal Hyperplasia (CAH) who were raised as females and older than 13years. As well as their relationship status and detailed medical history, an expert psychiatrist assessed their sexual orientation by a semi-structured psychiatric interview with them and, where applicable, their parents. Five percent of CAH participants and 42% of CAIS participants were in a relationship, which was significantly different. All CAH individuals had been diagnosed at birth; 89% of CAIS had been diagnosed after puberty and due to primary amenorrhea and 11% were diagnosed in childhood due to inguinal hernia. Genital reconstructive surgery had been performed in 100% of CAH participants and 37% of CAIS. Regarding sexual contact experiences and sexual fantasies (androphilic, gynephilic or both), no significant differences were found. However, CAH females had significantly more gynephilic dreams (P=0.045). This study, notable as one of the rare from a non-western culture, described sexual, medical and socioeconomic status of 46,XX CAH and 46,XY CAIS individuals living in Iran. Although broadly in line with previous findings from Western cultures, Iranian CAH individuals had fewer romantic relationships, but in contrast to previous studies their sexual orientation was only different from CAIS in the contents of sexual dreams. Copyright © 2016 Elsevier Inc. All rights reserved.
Miranda-Casas, A; Marco-Taverner, R; Soriano-Ferrer, M; Melià de Alba, A; Simó-Casañ, P
2008-01-01
Different procedures have demonstrated efficacy to teach cognitive and metacognitive strategies to problem solving in mathematics. Some studies have used computer-based problem solving instructional programs. To analyze in students with learning disabilities the efficacy of a cognitive strategies training for problem solving, with three instructional delivery formats: a teacher-directed program (T-D), a computer-assisted instructional (CAI) program, and a combined program (T-D + CAI). Forty-four children with mathematics learning disabilities, between 8 and 10 years old participated in this study. The children were randomly assigned to one of the three instructional formats and a control group without cognitive strategies training. In the three instructional conditions which were compared all the students learnt problems solving linguistic and visual cognitive strategies trough the self-instructional procedure. Several types of measurements were used for analysing the possible differential efficacy of the three instructional methods implemented: solving problems tests, marks in mathematics, internal achievement responsibility scale, and school behaviours teacher ratings. Our findings show that the T-D training group and the T-D + CAI group improved significantly on math word problem solving and on marks in Maths from pre- to post-testing. In addition, the results indicated that the students of the T-D + CAI group solved more real-life problems and developed more internal attributions compared to both control and CAI groups. Finally, with regard to school behaviours, improvements in school adjustment and learning problems were observed in the students of the group with a combined instructional format (T-D + CAI).
Internet marketing directed at children on food and restaurant websites in two policy environments.
Kent, M Potvin; Dubois, L; Kent, E A; Wanless, A J
2013-04-01
Food and beverage marketing has been associated with childhood obesity yet little research has examined the influence of advertising policy on children's exposure to food/beverage marketing on the Internet. The purpose of this study was to assess the influence of Quebec's Consumer Protection Act and the self-regulatory Canadian Children's Food and Beverage Advertising Initiative (CAI) on food manufacturer and restaurant websites in Canada. A content analysis of 147 French and English language food and restaurant websites was undertaken. The presence of child-directed content was assessed and an analysis of marketing features, games and activities, child protection features, and the promotion of healthy lifestyle messages was then examined on those sites with child-directed content. There were statistically no fewer French language websites (n = 22) with child-directed content compared to English language websites (n = 27). There were no statistically significant differences in the number of the various marketing features, or in the average number of marketing features between the English and French websites. There were no fewer CAI websites (n = 14) with child-directed content compared to non-CAI websites (n = 13). The CAI sites had more healthy lifestyle messages and child protection features compared to the non-CAI sites. Systematic surveillance of the Consumer Protection Act in Quebec is recommended. In the rest of Canada, the CAI needs to be significantly expanded or replaced by regulatory measures to adequately protect children from the marketing of foods/beverages high in fat, sugar, and sodium on the Internet. Copyright © 2012 The Obesity Society.
Chen, Lei; Liu, Tao; Zhao, Xian
2018-06-01
The anatomical therapeutic chemical (ATC) classification system is a widely accepted drug classification scheme. This system comprises five levels and includes several classes in each level. Drugs are classified into classes according to their therapeutic effects and characteristics. The first level includes 14 main classes. In this study, we proposed two network-based models to infer novel potential chemicals deemed to belong in the first level of ATC classification. To build these models, two large chemical networks were constructed using the chemical-chemical interaction information retrieved from the Search Tool for Interactions of Chemicals (STITCH). Two classic network algorithms, shortest path (SP) and random walk with restart (RWR) algorithms, were executed on the corresponding network to mine novel chemicals for each ATC class using the validated drugs in a class as seed nodes. Then, the obtained chemicals yielded by these two algorithms were further evaluated by a permutation test and an association test. The former can exclude chemicals produced by the structure of the network, i.e., false positive discoveries. By contrast, the latter identifies the most important chemicals that have strong associations with the ATC class. Comparisons indicated that the two models can provide quite dissimilar results, suggesting that the results yielded by one model can be essential supplements for those obtained by the other model. In addition, several representative inferred chemicals were analyzed to confirm the reliability of the results generated by the two models. This article is part of a Special Issue entitled: Accelerating Precision Medicine through Genetic and Genomic Big Data Analysis edited by Yudong Cai & Tao Huang. Copyright © 2017 Elsevier B.V. All rights reserved.
A heuristic model for working memory deficit in schizophrenia.
Qi, Zhen; Yu, Gina P; Tretter, Felix; Pogarell, Oliver; Grace, Anthony A; Voit, Eberhard O
2016-11-01
The life of schizophrenia patients is severely affected by deficits in working memory. In various brain regions, the reciprocal interactions between excitatory glutamatergic neurons and inhibitory GABAergic neurons are crucial. Other neurotransmitters, in particular dopamine, serotonin, acetylcholine, and norepinephrine, modulate the local balance between glutamate and GABA and therefore regulate the function of brain regions. Persistent alterations in the balances between the neurotransmitters can result in working memory deficits. Here we present a heuristic computational model that accounts for interactions among neurotransmitters across various brain regions. The model is based on the concept of a neurochemical interaction matrix at the biochemical level and combines this matrix with a mobile model representing physiological dynamic balances among neurotransmitter systems associated with working memory. The comparison of clinical and simulation results demonstrates that the model output is qualitatively very consistent with the available data. In addition, the model captured how perturbations migrated through different neurotransmitters and brain regions. Results showed that chronic administration of ketamine can cause a variety of imbalances, and application of an antagonist of the D2 receptor in PFC can also induce imbalances but in a very different manner. The heuristic computational model permits a variety of assessments of genetic, biochemical, and pharmacological perturbations and serves as an intuitive tool for explaining clinical and biological observations. The heuristic model is more intuitive than biophysically detailed models. It can serve as an important tool for interdisciplinary communication and even for psychiatric education of patients and relatives. This article is part of a Special Issue entitled "System Genetics" Guest Editor: Dr. Yudong Cai and Dr. Tao Huang. Copyright © 2016 Elsevier B.V. All rights reserved.
Chisholm, Rebecca H; Lorenzi, Tommaso; Clairambault, Jean
2016-11-01
Drug-induced drug resistance in cancer has been attributed to diverse biological mechanisms at the individual cell or cell population scale, relying on stochastically or epigenetically varying expression of phenotypes at the single cell level, and on the adaptability of tumours at the cell population level. We focus on intra-tumour heterogeneity, namely between-cell variability within cancer cell populations, to account for drug resistance. To shed light on such heterogeneity, we review evolutionary mechanisms that encompass the great evolution that has designed multicellular organisms, as well as smaller windows of evolution on the time scale of human disease. We also present mathematical models used to predict drug resistance in cancer and optimal control methods that can circumvent it in combined therapeutic strategies. Plasticity in cancer cells, i.e., partial reversal to a stem-like status in individual cells and resulting adaptability of cancer cell populations, may be viewed as backward evolution making cancer cell populations resistant to drug insult. This reversible plasticity is captured by mathematical models that incorporate between-cell heterogeneity through continuous phenotypic variables. Such models have the benefit of being compatible with optimal control methods for the design of optimised therapeutic protocols involving combinations of cytotoxic and cytostatic treatments with epigenetic drugs and immunotherapies. Gathering knowledge from cancer and evolutionary biology with physiologically based mathematical models of cell population dynamics should provide oncologists with a rationale to design optimised therapeutic strategies to circumvent drug resistance, that still remains a major pitfall of cancer therapeutics. This article is part of a Special Issue entitled "System Genetics" Guest Editor: Dr. Yudong Cai and Dr. Tao Huang. Copyright © 2016 Elsevier B.V. All rights reserved.
A Comparative Evaluation of Computer Based and Non-Computer Based Instructional Strategies.
ERIC Educational Resources Information Center
Emerson, Ian
1988-01-01
Compares the computer assisted instruction (CAI) tutorial with its non-computerized pedagogical roots: the Socratic Dialog with Skinner's Programmed Instruction. Tests the effectiveness of a CAI tutorial on diffusion and osmosis against four other interactive and non-interactive instructional strategies. Notes computer based strategies were…
Evaluation and Validation (E&V) Team Public Report Volume 4
1989-01-01
group’s accomplishments include: a proposal for developing new technology including enhancements to ACEC (from a prioritized list of requirements) and...SEVWG) Status Report SEVWG reported no deliverables due. The group’s accomplishments include: the Guidebook entry for CAIS/CAIS-A; interchange meeting
Cost-Effectiveness of Alternative Approaches to Computer-Assisted Instruction.
ERIC Educational Resources Information Center
Levin, Henry M.; And Others
Operating on the premise that different approaches to computer-assisted instruction (CAI) may use different configurations of hardware and software, different curricula, and different organizational and personnel arrangements, this study explored the feasibility of collecting evaluations of CAI to evaluate the comparative cost-effectiveness of…
Bermúdez de la Vega, José A; Fernández-Cancio, Mónica; Bernal, Susana; Audí, Laura
2015-01-01
In 4 complete androgen insensitivity syndrome (CAIS) members of one family, 2 presented extreme and unusual clinical features: male gender identity disorder (case 1) and female precocious central puberty (case 2). The AR gene carried the mutation c.1752C>G, p.Phe584Leu. Gender dysphoria in CAIS may be considered as a true transgender and has been described in 3 other cases. Central precocious puberty has only been described in 1 case; Müllerian ducts in case 2 permitted menarche. Despite the common CAIS phenotype, there was a familial disparity for gender identity adequacy and timing and type of puberty.
Watzlaf, V J; Addeo, L; Nous, A
1995-11-01
The development of an epidemiological research proposal can be a difficult assignment for junior health information management students. The article demonstrates how a computer-assisted instructional (CAI) tool was developed to assist students in the development of an epidemiological research proposal. Surveys were conducted to determine where students were having the most problems, information about writing a research proposal was gathered and organized into an appropriate format, appropriate software (Hypercard) was chosen, the final CAI tool (the Research and Grant Writer) was developed, and positive feedback was obtained from junior health information management students using the CAI tool.
Mautone, Jennifer A; DuPaul, George J; Jitendra, Asha K
2005-08-01
The present study examines the effects of computer-assisted instruction (CAI) on the mathematics performance and classroom behavior of three second-through fourth-grade students with ADHD. A controlled case study is used to evaluate the effects of the computer software on participants' mathematics performance and on-task behavior. Participants' mathematics achievement improve and their on-task behavior increase during the CAI sessions relative to independent seatwork conditions. In addition, students and teachers consider CAI to be an acceptable intervention for some students with ADHD who are having difficulty with mathematics. Implications of these results for practice and research are discussed.
Kim, Kyung-Min; Hart, Joseph M.; Saliba, Susan A.; Hertel, Jay
2016-01-01
Context: Individuals with chronic ankle instability (CAI) present with decreased modulation of the Hoffmann reflex (H-reflex) from a simple to a more challenging task. The neural alteration is associated with impaired postural control, but the relationship has not been investigated in individuals with CAI. Objective: To determine differences in H-reflex modulation and postural control between individuals with or without CAI and to identify if they are correlated in individuals with CAI. Design: Descriptive laboratory study. Setting: Laboratory. Patients or Other Participants: A total of 15 volunteers with CAI (9 males, 6 females; age = 22.6 ± 5.8 years, height = 174.7 ± 8.1 cm, mass = 74.9 ± 12.8 kg) and 15 healthy sex-matched volunteers serving as controls (9 males, 6 females; age = 23.8 ± 5.8 years, height = 171.9 ± 9.9 cm, mass = 68.9 ± 15.5 kg) participated. Intervention(s): Maximum H-reflex (Hmax) and motor wave (Mmax) from the soleus and fibularis longus were recorded while participants lay prone and then stood in unipedal stance. We assessed postural tasks of unipedal stance with participants' eyes closed for 10 seconds using a forceplate. Main Outcome Measure(s): We normalized Hmax to Mmax to obtain Hmax : Mmax ratios for the 2 positions. For each muscle, H-reflex modulation was quantified using the percentage change scores in Hmax : Mmax ratios calculated from prone position to unipedal stance. Center-of-pressure data were used to compute 4 time-to-boundary variables. Separate independent-samples t tests were performed to determine group differences. Pearson product moment correlation coefficients were calculated between the modulation and balance measures in the CAI group. Results: The CAI group presented less H-reflex modulation in the soleus (t26 = −3.77, P = .001) and fibularis longus (t25 = −2.59, P = .02). The mean of the time-to-boundary minima in the anteroposterior direction was lower in the CAI group (t28 = −2.06, P = .048
Is the Computer Revolution About to Happen in the Classroom?
ERIC Educational Resources Information Center
Smith, S.
1984-01-01
Both practical and irrational factors will substantially delay the widespread use of computer-assisted instruction (CAI) in Australia's schools, including the following: lack of suitable software, insufficient hardware, ignorance of what CAI offers, lack of expert advice, computer anxiety, reaction against computer zealots, and resistance to…
ERIC Educational Resources Information Center
Simonson, Michael R., Ed.; Frederick, Jacqueline K., Ed.
1988-01-01
The 54 papers in this volume represent some of the most current thinking in educational communications and technology. Individual papers address the following topics: feedback in computer-assisted instruction (CAI); cognitive style and cognitive strategies in CAI; persuasive film-making; learning strategies; computer technology and children's word…
ERIC Educational Resources Information Center
Association for Educational Data Systems, Washington, DC.
Two abstracts and seventeen articles on computer assisted instruction (CAI) presented at the 1976 Association for Educational Data Systems (AEDS) convention are included here. Four new computer programs are described: Author System for Education and Training (ASET); GNOSIS, a Swedish/English CAI package; Statistical Interactive Programming System…
ERIC Educational Resources Information Center
Longberg, Pauline Oliphant
2012-01-01
As computer assisted instruction (CAI) becomes increasingly sophisticated, its appeal as a viable method of literacy intervention with young children continues despite limited evidence of effectiveness. The present study sought to assess the impact of one such CAI program, "Imagine Learning English" (ILE), on both the receptive…
ERIC Educational Resources Information Center
Bruce, A. Wayne
1986-01-01
Describes reasons for developing combined text and computer assisted instruction (CAI) teaching programs for delivery of continuing education to laboratory professionals, and mechanisms used for developing a CAI program on method evaluation in the clinical laboratory. Results of an evaluation of the software's cost effectiveness and instructional…
ERIC Educational Resources Information Center
Baker, Justine C.
1978-01-01
Historic perspective of computer manufacturers and their contribution to CAI. Corporate CAI products and services are mentioned, as is a forecast for educational involvement by computer corporations. A chart of major computer corporations shows gross sales, net earnings, products and services offered, and other corporate information. (RAO)
Analyzing and Modifying Coaching Behaviors by Means of Computer Aided Observation.
ERIC Educational Resources Information Center
Partridge, David; Franks, Ian M.
1996-01-01
This study examined the effectiveness of the Coaching Analysis Instrument (CAI), which collects data and provides feedback on coaches' verbal behaviors as they organize and instruct athletes during practices. Practice sessions were videotaped and analyzed. CAI results helped modify the coaches' behaviors in positive ways. (SM)
ERIC Educational Resources Information Center
Dede, Christopher J.; And Others
The first of five sections in this report places intelligent computer-assisted instruction (ICAI) in its historical context through discussions of traditional computer-assisted instruction (CAI) linear and branching programs; TICCIT and PLATO IV, two CAI demonstration projects funded by the National Science Foundation; generative programs, the…
ERIC Educational Resources Information Center
Boody, Charles G., Ed.
1986-01-01
Six articles on music and computing address development of computer-based music technology, computer assisted instruction (CAI) in ear training and music fundamentals, a machine-independent data structure for musical pitch relationship representation, touch tablet input device in a melodic dictation CAI game, and systematic evaluation strategies…
Brennecka, Gregory A.; Borg, Lars E.; Wadhwa, Meenakshi
2013-01-01
The isotopic composition of our Solar System reflects the blending of materials derived from numerous past nucleosynthetic events, each characterized by a distinct isotopic signature. We show that the isotopic compositions of elements spanning a large mass range in the earliest formed solids in our Solar System, calcium–aluminum-rich inclusions (CAIs), are uniform, and yet distinct from the average Solar System composition. Relative to younger objects in the Solar System, CAIs contain positive r-process anomalies in isotopes A < 140 and negative r-process anomalies in isotopes A > 140. This fundamental difference in the isotopic character of CAIs around mass 140 necessitates (i) the existence of multiple sources for r-process nucleosynthesis and (ii) the injection of supernova material into a reservoir untapped by CAIs. A scenario of late supernova injection into the protoplanetary disk is consistent with formation of our Solar System in an active star-forming region of the galaxy. PMID:24101483
Stephenson, Rob; Finneran, Catherine
2017-08-01
Intimate partner violence (IPV) rates are disproportionately high among sexual minority populations, with increasing evident that gay men experience IPV at the same rates as heterosexual women. This study examines the relationship between self-reported condomless anal intercourse (CAI) and IPV among a sample of 750 gay and bisexual men. Participants answered questions regarding recent receipt and perpetration of IPV using the IPV-GBM Scale (Cronbach Alpha 0.90). Of the sample, 46.1% reported recent receipt of any type of IPV and 33.6% reported recent perpetration of any type of IPV. Overall, 55.1% of participants reported CAI at last sex. Significant associations were determined between several forms of IPV and increased odds of reporting CAI at last sex. These findings suggest that IPV may be a risk factor for CAI among men who have sex with men, and highlight the need to understand the IPV prevention and care needs of this population.
Newcomb, Michael E; Mustanski, Brian
2016-06-01
Young men who have sex with men are substantially impacted by HIV/AIDS, and most new infections occur in serious romantic dyads. Young people experience substantial psychosocial and neurocognitive change between adolescence and emerging adulthood which impacts engagement in risk behaviors. We aimed to examine developmental change in the association between sexual partnership characteristics and condomless anal intercourse (CAI). Data were taken from an analytic sample of 114 young adult MSM from a longitudinal study of lesbian, gay, bisexual and transgender youth with 4-year follow-up. Rates of CAI were approximately 12 times higher in serious compared to casual partnerships, but this effect diminished in size over time. Partner age differences and violence were associated with more CAI, and these associations strengthened across development. Characteristics of serious relationships (e.g., power dynamics) were also examined. We discuss the need for HIV prevention strategies that address dyadic influences on CAI during this critical developmental period.
Shaw, M J; Beebe, T J; Tomshine, P A; Adlis, S A; Cass, O W
2001-02-01
The purpose of our study was to assess the effectiveness of computer-assisted instruction (CAI) in patients having colonoscopies. We conducted a randomized, controlled trial in large, multispecialty clinic. Eighty-six patients were referred for colonoscopies. The interventions were standard education versus standard education plus CAI, and the outcome measures were anxiety, comprehension, and satisfaction. Computer-assisted instruction had no effect on patients' anxiety. The group receiving CAI demonstrated better overall comprehension (p < 0.001). However, Comprehension of certain aspects of serious complications and appropriate postsedation behavior were unaffected by educational method. Patients in the CAI group were more likely to indicate satisfaction with the amount of information provided when compared with the standard education counterparts (p = 0.001). Overall satisfaction was unaffected by educational method. Computer-assisted instruction for colonoscopy provided better comprehension and greater satisfaction with the adequacy of education than standard education. Computer-assisted instruction helps physicians meet their educational responsibilities with no decrement to the interpersonal aspects of the patient-physician relationship.
Newcomb, Michael E.; Mustanski, Brian
2015-01-01
Young men who have sex with men (MSM) are substantially impacted by HIV/AIDS, and most new infections occur in serious romantic dyads. Young people experience substantial psychosocial and neurocognitive change between adolescence and emerging adulthood which impacts engagement in risk behaviors. We aimed to examine developmental change in the association between sexual partnership characteristics and condomless anal intercourse (CAI). Data were taken from an analytic sample of 114 YMSM from a longitudinal study of lesbian, gay, bisexual and transgender youth with 4-year follow-up. Rates of CAI were approximately 12 times higher in serious compared to casual partnerships, but this effect diminished in size over time. Partner age differences and violence were associated with more CAI, and these associations strengthened across development. Characteristics of serious relationships (e.g., power dynamics) were also examined. We discuss the need for HIV prevention strategies that address dyadic influences on CAI during this critical developmental period. PMID:25861731
SCREENING FOR PTSD AMONG INCARCERATED MEN
WOLFF, NANCY; GREGORY CHUGO, M; SHI, JING; HUENING, JESSICA; FRUEH, B. CHRISTOPHER
2014-01-01
Trauma exposure is overrepresented in incarcerated male populations and is linked to psychiatric morbidity, particularly posttraumatic stress disorder (PTSD). This study tests the feasibility, reliability, and validity of using computer-administered interviewing (CAI) versus orally administered interviewing (OAI) to screen for PTSD among incarcerated men. A 2 × 2 factorial design was used to randomly assign 592 incarcerated men to screening modality. Findings indicate that computer screening was feasible. Compared with OAI, CAI produced equally reliable screening information on PTSD symptoms, with test–retest intraclass correlations for the PTSD Checklist (PCL) total score ranging from .774 to .817, and the Clinician-Administered PTSD scale and PCL scores were significantly correlated for OAI and CAI. These findings indicate that data on PTSD symptoms can be reliably and validly obtained from CAI technology, increasing the efficiency by which incarcerated populations can be screened for PTSD, and those at risk can be identified for treatment. PMID:25673900