Sample records for tasire ghodrate ioni

  1. Assessing mNIS+7Ionis and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial.

    PubMed

    Dyck, Peter J; Kincaid, John C; Dyck, P James B; Chaudhry, Vinay; Goyal, Namita A; Alves, Christina; Salhi, Hayet; Wiesman, Janice F; Labeyrie, Celine; Robinson-Papp, Jessica; Cardoso, Márcio; Laura, Matilde; Ruzhansky, Katherine; Cortese, Andrea; Brannagan, Thomas H; Khoury, Julie; Khella, Sami; Waddington-Cruz, Márcia; Ferreira, João; Wang, Annabel K; Pinto, Marcus V; Ayache, Samar S; Benson, Merrill D; Berk, John L; Coelho, Teresa; Polydefkis, Michael; Gorevic, Peter; Adams, David H; Plante-Bordeneuve, Violaine; Whelan, Carol; Merlini, Giampaolo; Heitner, Stephen; Drachman, Brian M; Conceição, Isabel; Klein, Christopher J; Gertz, Morie A; Ackermann, Elizabeth J; Hughes, Steven G; Mauermann, Michelle L; Bergemann, Rito; Lodermeier, Karen A; Davies, Jenny L; Carter, Rickey E; Litchy, William J

    2017-11-01

    Polyneuropathy signs (Neuropathy Impairment Score, NIS), neurophysiologic tests (m+7 Ionis ), disability, and health scores were assessed in baseline evaluations of 100 patients entered into an oligonucleotide familial amyloidotic polyneuropathy (FAP) trial. We assessed: (1) Proficiency of grading neurologic signs and correlation with neurophysiologic tests, and (2) clinometric performance of modified NIS+7 neurophysiologic tests (mNIS+7 Ionis ) and its subscores and correlation with disability and health scores. The mNIS+7 Ionis sensitively detected, characterized, and broadly scaled diverse polyneuropathy impairments. Polyneuropathy signs (NIS and subscores) correlated with neurophysiology tests, disability, and health scores. Smart Somatotopic Quantitative Sensation Testing of heat as pain 5 provided a needed measure of small fiber involvement not adequately assessed by other tests. Specially trained neurologists accurately assessed neuropathy signs as compared to referenced neurophysiologic tests. The score, mNIS+7 Ionis , broadly detected, characterized, and scaled polyneuropathy abnormality in FAP, which correlated with disability and health scores. Muscle Nerve 56: 901-911, 2017. © 2017 Wiley Periodicals, Inc.

  2. Temporal variability in lipoprotein(a) levels in patients enrolled in the placebo arms of IONIS-APO(a)Rx and IONIS-APO(a)-LRx antisense oligonucleotide clinical trials.

    PubMed

    Marcovina, Santica M; Viney, Nicholas J; Hughes, Steven G; Xia, Shuting; Witztum, Joseph L; Tsimikas, Sotirios

    Lipoprotein(a) [Lp(a)] levels are primarily genetically determined, but their natural variability is not well known. The aim of the study was to evaluate the short-term temporal variability in Lp(a) in 3 placebo groups from the IONIS-APO(a) Rx and IONIS-APO(a)-L Rx trials. The placebo groups comprised 3 studies: Study 1 with 10 subjects with any Lp(a) concentration; Study 2 with 13 subjects with Lp(a) ≥75 nmol/L (∼30 mg/dL); and Study 3 with 29 patients with Lp(a) ≥125 nmol/L (≥∼50 mg/dL). Lp(a) was measured in serial blood samples (range 7-12 samples up to 190 days of follow-up) and analyzed as absolute change and mean percent change from baseline. Outliers were defined as having a > ±25% difference in Lp(a) from baseline at any future time point. No significant temporal differences in mean absolute Lp(a) levels were present in any group. However, among individuals, the mean change in absolute Lp(a) levels at any time point ranged from -16.2 to +7.0 nmol/L in Study 1, -15.8 to +9.8 nmol/L in Study 2, and -60.2 to +16.6 nmol/L in Study 3. The mean percent change from baseline ranged from -9.4% to +21.6% for Study 1, -13.1% to 2.8% for Study 2, and -12.1% to +4.9% in Study 3. A total of 21 of 52 subjects (40.4%) were outliers, with 13 (62%) >25% up and 8 (38%) >25% down. Significant variability was also noted in other lipid parameters, but no outliers were noted with serum albumin. In subjects randomized to placebo in Lp(a) lowering trials, modest intra-individual temporal variability of mean Lp(a) levels was present. Significant number of subjects had > ±25% variation in Lp(a) in at least 1 time point. Although Lp(a) levels are primarily genetically determined, further study is required to define additional factors mediating short-term variability. Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  3. Calorimetria nucleare in collisioni tra ioni pesanti ad energie intermedie

    NASA Astrophysics Data System (ADS)

    Spezzi, L.

    2002-07-01

    Nel presente lavoro di tesi ci si e' occupati di uno studio sistematico di misure di temperatura ed energia di eccitazione in sistemi nucleari formati in reazioni tra ioni pesanti ad energie intermedie. La temperatura a stata misurata tramite due diversi metodi: rapporto tra le rese di isotopi che differiscono di uno stesso numero di nucleoni ( d/t-3He/4He , 3He/4He -6Li/7Li) - temperatura isotopica -, e rapporto tra le popolazioni degli stati eccitati in frammenti instabili (5Li e 6Li) che decadono in particelle leggere in coincidenza - temperatura di emissione. Le misure in esame sono state effettuate presso i Laboratori Nazionali del Sud per i sistemi 93Nb+93Nb, 93Nb+116,124Sn, 116,120Sn+116,124Sn e 116Sn+93Nb ad energie comprese tra 17 e 40 A MeV. L'apparato di rivelazione era costituito da un odoscopio ad alta granularite (96 telescopi Si (50micron)-Si(300micron)-CsI(Tl) ) e basse soglie di rivelazione, utilizzato sia per identificare risonanze in frammenti eccitati che per misure di rese di isotopi di frammenti con 2<=Z<=6, e dal multirivelatore FIASCO che, grazie alla misura contemporanea di posizione e tempo di volo dei frammenti provenienti dal proiettile (PLF - Projectile Like Fragments) e dal bersaglio (TLF - Target Like Fragment), e' stato utilizzato per misurare direttamente l'energia di eccitazione del sistema in studio. Analisi precedenti, condotte nell'ambito di varie collaborazioni, hanno messo in evidenza la possible esistenza di una transizione di fase liquido-gas del primo ordine nella materia nucleare. In tale contesto, ci siamo occupati di una verifica della curva calorica nucleare, ovvero della correlazione esistente fra temperatura ed energia di eccitazione del sistema, indagando, nel contempo, sulla sua dipendenza dalla massa del sistema che si frammenta. Si e' effettuato, inoltre, un confronto fra i due diversi metodi di misura della temperatura (temperatura isotopica e di emissione): l'andamento plateau-like della curva calorica e' stato

  4. Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.

    PubMed

    Viney, Nicholas J; van Capelleveen, Julian C; Geary, Richard S; Xia, Shuting; Tami, Joseph A; Yu, Rosie Z; Marcovina, Santica M; Hughes, Steven G; Graham, Mark J; Crooke, Rosanne M; Crooke, Stanley T; Witztum, Joseph L; Stroes, Erik S; Tsimikas, Sotirios

    2016-11-05

    Elevated lipoprotein(a) (Lp[a]) is a highly prevalent (around 20% of people) genetic risk factor for cardiovascular disease and calcific aortic valve stenosis, but no approved specific therapy exists to substantially lower Lp(a) concentrations. We aimed to assess the efficacy, safety, and tolerability of two unique antisense oligonucleotides designed to lower Lp(a) concentrations. We did two randomised, double-blind, placebo-controlled trials. In a phase 2 trial (done in 13 study centres in Canada, the Netherlands, Germany, Denmark, and the UK), we assessed the effect of IONIS-APO(a) Rx , an oligonucleotide targeting apolipoprotein(a). Participants with elevated Lp(a) concentrations (125-437 nmol/L in cohort A; ≥438 nmol/L in cohort B) were randomly assigned (in a 1:1 ratio in cohort A and in a 4:1 ratio in cohort B) with an interactive response system to escalating-dose subcutaneous IONIS-APO(a) Rx (100 mg, 200 mg, and then 300 mg, once a week for 4 weeks each) or injections of saline placebo, once a week, for 12 weeks. Primary endpoints were mean percentage change in fasting plasma Lp(a) concentration at day 85 or 99 in the per-protocol population (participants who received more than six doses of study drug) and safety and tolerability in the safety population. In a phase 1/2a first-in-man trial, we assessed the effect of IONIS-APO(a)-L Rx , a ligand-conjugated antisense oligonucleotide designed to be highly and selectively taken up by hepatocytes, at the BioPharma Services phase 1 unit (Toronto, ON, Canada). Healthy volunteers (Lp[a] ≥75 nmol/L) were randomly assigned to receive a single dose of 10-120 mg IONIS-APO(a)L Rx subcutaneously in an ascending-dose design or placebo (in a 3:1 ratio; single-ascending-dose phase), or multiple doses of 10 mg, 20 mg, or 40 mg IONIS-APO(a)L Rx subcutaneously in an ascending-dose design or placebo (in an 8:2 ratio) at day 1, 3, 5, 8, 15, and 22 (multiple-ascending-dose phase). Primary endpoints were mean percentage change

  5. Canonical Word Order of Japanese Ditransitive Sentences: A Preliminary Investigation through a Grammaticality Judgment Survey

    ERIC Educational Resources Information Center

    Shigenaga, Yasumasa

    2014-01-01

    There have been three competing analyses regarding the canonical word order of Japanese ditransitive sentences: a) "S-'ga' IO-'ni' DO-'o' V" is the canonical word order rather than "S-'ga' DO-'o' IO-'ni' V", b) both word orders are canonical, and c) the canonical word order depends on the type of the verb. The present study…

  6. Occupational exposure to ionizing radiation for crews of suborbital spacecraft : questions & answers.

    DOT National Transportation Integrated Search

    2013-12-01

    Crewmembers on future suborbital commercial spaceflights will be occupationally exposed to ionizing radiation, principally from galactic cosmic radiation. On infrequent occasions, the sun or thunderstorms may also contribute significantly to the ioni...

  7. Dose-Dependent Lowering of Mutant Huntingtin Using Antisense Oligonucleotides in Huntington Disease Patients.

    PubMed

    van Roon-Mom, Willeke M C; Roos, Raymund A C; de Bot, Susanne T

    2018-04-01

    On December 11 of 2017, Ionis Pharmaceuticals published a press release announcing dose-dependent reductions of mutant huntingtin protein in their HTTRx Phase 1/2a study in Huntington disease (HD) patients. The results from this Ionis trial have gained much attention from the patient community and the oligonucleotide therapeutics field, since it is the first trial targeting the cause of HD, namely the mutant huntingtin protein, using antisense oligonucleotides (ASOs). The press release also states that the primary endpoints of the study (safety and tolerability) were met, but does not contain data. This news follows the approval of another therapeutic ASO nusinersen (trade name Spinraza) for a neurological disease, spinal muscular atrophy, by the U.S. Food and Drug Administration and European Medicines Agency, in 2016 and 2017, respectively. Combined, this offers hope for the development of the HTTRx therapy for HD patients.

  8. Manipulating dispersion and distribution of graphene in PLA through Novel Interface Engineering for improved conductive properties

    USDA-ARS?s Scientific Manuscript database

    This study aimed to enhance the conductive properties of PLA nanocomposite by controlling the dispersion and distribution of graphene within the minor phase of the polymer blend. Functionalized graphene (f-GO) was achieved by reacting graphene oxide (GO) with various silanes under the aid of an ioni...

  9. Manipulating dispersion and distribution of graphene in PLA through novel interface engineering for improved conductive properties

    USDA-ARS?s Scientific Manuscript database

    This study aimed to enhance the conductive properties of PLA nanocomposite by controlling the dispersion and distribution of graphene within the minor phase of the polymer blend. Functionalized graphene (f-GO) was achieved by reacting graphene oxide (GO) with various silanes under the aid of an ioni...

  10. Electrical Degradation in Ceramic Dielectrics

    DTIC Science & Technology

    1988-09-09

    and D. M. Smyth, " Positron Annihilation in Calcium-Doped Barium Titanate", in Electro- Ceramics and Solid State Ionsi, H. L. Tuller and D. M. Smyth...2 with the formation of ompensating oxygen vacancies, and this causes an increase in the ioni conductivity: 2CaO CaC + Call + 20 + (5) TiO2 --- V

  11. Huntington’s Disease Clinical Trials Corner: February 2018

    PubMed Central

    Rodrigues, Filipe B.; Wild, Edward J.

    2018-01-01

    In the second edition of the Huntington’s Disease Clinical Trials Corner we list all currently registered and ongoing clinical trials, summarise the top-line results of the recently-announced IONIS-HTTRX trial (NCT02519036), expand on Wave Life Sciences’ PRECISION-HD1 (NCT03225833) and PRECISION-HD2 (NCT03225846), and cover one recently finished trial: the FIRST-HD deutetrabenazine trial (NCT01795859). PMID:29480210

  12. Mass Spectrometry Vapor Analysis for Improving Explosives Detection Canine Proficiency

    DTIC Science & Technology

    2017-02-10

    ionization (SESI), 8,19-21 dielectric barrier discharge ionization (DBDI), 21,22 selected-ion-flow-tube (SIFT), 23,24 and proton transfer reaction...handled only with wood- en or Teflon® spatulas to prevent static discharge . Using these precautions, we never experienced an accidental detonation...ionization (SESI) and dielectric barrier discharge ionization (DBDI) sources were used for vapor ioni- zation. Source temperature was held at 100 o C

  13. Metabolite Identification of Halon Replacement Compounds.

    DTIC Science & Technology

    1992-06-01

    inhalation to a 1 % atmosphere for 2 h. Tlissues were analyzed for volatile metabolites, and urine was analyzed for fluoride and carboxylic acid metabolites...M*vass Spectrometry, lialocarbons, 35 lialon 1211, IICFC- 123, IICIFC 124, IICFC 142b, llvdro~chlorofluoro-tcarbIonis ( 1 ICFCs), Inhalation Exposure...trifluoroethane HCFC- 142b 1 -Chloro-1,1 - difluoroethane HCI Hydrochloric acid kg Kilogram L Liter m Meter M Moles/liter mg Milligram MHz Megahertz min Minute

  14. Domain Decomposition with Local Mesh Refinement.

    DTIC Science & Technology

    1989-08-01

    smoothi coefficients, or non-smooth solui ioni,. We eiriplov fromn 1 to 1024 tiles on problems containing irp to 161K (degrees of freedom. Though io... methodology survives such compromises and is even sequentially advantageous in many problems. The domain decomposition algorithms we employ (sertiun 3...iog( I + !J2 it - g i Ol Qunit squiare 1 he (,mai oive i> Hie outward normal. lfie sevoh iih exam pie, from [1. 27] has a smoothi solution, but rapidlY

  15. ISS-N1 makes the First FDA-approved Drug for Spinal Muscular Atrophy.

    PubMed

    Ottesen, Eric W

    2017-01-01

    Spinal muscular atrophy (SMA) is one of the leading genetic diseases of children and infants. SMA is caused by deletions or mutations of Survival Motor Neuron 1 ( SMN1 ) gene. SMN2 , a nearly identical copy of SMN1 , cannot compensate for the loss of SMN1 due to predominant skipping of exon 7. While various regulatory elements that modulate SMN2 exon 7 splicing have been proposed, intronic splicing silencer N1 (ISS-N1) has emerged as the most promising target thus far for antisense oligonucleotide-mediated splicing correction in SMA. Upon procuring exclusive license from the University of Massachussets Medical School in 2010, Ionis Pharmaceuticals (formerly ISIS Pharamaceuticals) began clinical development of Spinraza ™ (synonyms: Nusinersen, IONIS-SMN RX , ISIS-SMN RX ), an antisense drug based on ISS-N1 target. Spinraza ™ showed very promising results at all steps of the clinical development and was approved by US Food and Drug Administration (FDA) on December 23, 2016. Spinraza ™ is the first FDA-approved treatment for SMA and the first antisense drug to restore expression of a fully functional protein via splicing correction. The success of Spinraza ™ underscores the potential of intronic sequences as promising therapeutic targets and sets the stage for further improvement of antisense drugs based on advanced oligonucleotide chemistries and delivery protocols.

  16. ISS-N1 makes the First FDA-approved Drug for Spinal Muscular Atrophy

    PubMed Central

    Ottesen, Eric W.

    2017-01-01

    Abstract Spinal muscular atrophy (SMA) is one of the leading genetic diseases of children and infants. SMA is caused by deletions or mutations of Survival Motor Neuron 1 (SMN1) gene. SMN2, a nearly identical copy of SMN1, cannot compensate for the loss of SMN1 due to predominant skipping of exon 7. While various regulatory elements that modulate SMN2 exon 7 splicing have been proposed, intronic splicing silencer N1 (ISS-N1) has emerged as the most promising target thus far for antisense oligonucleotide-mediated splicing correction in SMA. Upon procuring exclusive license from the University of Massachussets Medical School in 2010, Ionis Pharmaceuticals (formerly ISIS Pharamaceuticals) began clinical development of Spinraza™ (synonyms: Nusinersen, IONIS-SMNRX, ISIS-SMNRX), an antisense drug based on ISS-N1 target. Spinraza™ showed very promising results at all steps of the clinical development and was approved by US Food and Drug Administration (FDA) on December 23, 2016. Spinraza™ is the first FDA-approved treatment for SMA and the first antisense drug to restore expression of a fully functional protein via splicing correction. The success of Spinraza™ underscores the potential of intronic sequences as promising therapeutic targets and sets the stage for further improvement of antisense drugs based on advanced oligonucleotide chemistries and delivery protocols. PMID:28400976

  17. Design Criteria for Deflection Capacity of Conventionally reinforced Concrete Slabs. Phase III. Summary of Design Criteria and Design and Construction Details - Design Examples.

    DTIC Science & Technology

    1980-10-01

    34 * M 0 0 rn a____ ______ I 𔃾 oa to 0 3 ji __1 .41 .. LL U9~ .1 4 0 -P_ 104 In 41 𔃾 C3 ) oY uo 0 1 P !Eo’a 020 Vi-4 1411313 3SdV-11O3 iN31dIONI -20...basic development length for Grade 60 hooked reinforcement, Rhb is given by: 960 db 2 hb 9 d (in.) (3-4) c Effects of yield stress of reinforcement

  18. A General Explanation-Based Learning Mechanism and Its Application to Narrative Understanding.

    DTIC Science & Technology

    1987-12-01

    sitive emotional relationship with the victim and conse- cquentlv valued her freedom more than personal possessions. This generalization is important...Generalizing Algorithin 2tc.as - men r.red rh rev;ous foo-.r.ote. *.he Bac&?-,-a~a,.e ucjr.presented i.:ony b dCei rol prCp 711 pro-agatc C r~~sac-oss orcs the...explanation. As men - tioned earlier. PROLOC-EBG elegantly integrates generalization with the theorem proving process. and MRS-EBG elegan ti

  19. The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials

    PubMed Central

    Baker, Brenda F.; Witztum, Joseph L.; Kwoh, T. Jesse; Pham, Nguyen C.; Salgado, Nelson; McEvoy, Bradley W.; Cheng, Wei; Hughes, Steven G.; Bhanot, Sanjay; Geary, Richard S.

    2017-01-01

    A thorough analysis of clinical trial data in the Ionis integrated safety database (ISDB) was performed to determine if there is a class effect on platelet numbers and function in subjects treated with 2′-O-methoxyethyl (2′MOE)-modified antisense oligonucleotides (ASOs). The Ionis ISDB includes over 2,600 human subjects treated with 16 different 2′MOE ASOs in placebo-controlled and open-label clinical trials over a range of doses up to 624 mg/week and treatment durations as long as 4.6 years. This analysis showed that there is no class generic effect on platelet numbers and no incidence of confirmed platelet levels below 50 K/μL in subjects treated with 2′MOE ASOs. Only 7 of 2,638 (0.3%) subjects treated with a 2′MOE ASO experienced a confirmed postbaseline (BSLN) platelet count between 100 and 50 K/μL. Three of sixteen 2′MOE ASOs had >10% incidence of platelet decreases >30% from BSLN, suggesting that certain sequences may associate with clinically insignificant platelet declines. Further to these results, we found no evidence that 2′MOE ASOs alter platelet function, as measured by the lack of clinically relevant bleeding in the presence or absence of other drugs that alter platelet function and/or number and by the results from trials conducted with the factor XI (FXI) ASO. PMID:28145801

  20. Annotated Bibliography of USAARL (United States Army Aeromedical Research Laboratory) Technical and Letter Reports, 1 June 1963 - 30 April 1983.

    DTIC Science & Technology

    1983-04-01

    anticipated either a noxious event (electric shock) or a benign event (bell). Within each condition, four groups performed the task, each with a...privent ronsi stent identif tet ioni of traits associated wi th pilot-error groups 75-1 This Report Number was not used 75-17 ti-fl ighit eva t arion...1R-77-13-1-2 Idiopathic hypertrophic suhaortic stenosis (ItSS) - I.R-75-35-1-11 Impact testing - LR-74-28-3-5, 75-11-3-1, 75-16-3-2, 76-15-2-3, 78-7-3

  1. Ideas and Weapons.

    DTIC Science & Technology

    1983-01-01

    certain that our system is adequate to ensure this superiority. The experience of men who have grappled with this problem in the past should prove valuable...Nh’lre , Ini tlac prep’lira- lonl of th is Stuiillv, thle authIor coliliIl ted t1; p)e’Cri pt drafts of Chap- t(Trs "U cl ’’ fIile (mie men t ionied ab ove...thousand men led by a renowned officer landed on the coast of Normandy and pressed eastward in a raiding expedition penetrating almost to Paris. The

  2. Hydrographic observations by instrumented marine mammals in the Sea of Okhotsk

    NASA Astrophysics Data System (ADS)

    Nakanowatari, Takuya; Ohshima, Kay I.; Mensah, Vigan; Mitani, Yoko; Hattori, Kaoru; Kobayashi, Mari; Roquet, Fabien; Sakurai, Yasunori; Mitsudera, Humio; Wakatsuchi, Masaaki

    2017-09-01

    The Sea of Okhotsk is a challenging environment for obtaining in situ data and satellite observation in winter due to sea ice cover. In this study, we evaluated the validity of hydrographic observations by marine mammals (e.g., seals and sea lions) equipped with oceanographic conductivity-temperature-depth (CTD) sensors. During 4-yr operations from 2011 to 2014, we obtained total of 997 temperature-salinity profiles in and around the Soya Strait, Iony Island, and Urup Strait. The hydrographic data were mainly obtained from May to August and the maximum profile depth in shelf regions almost reaches to the seafloor, while valuable hydrographic data under sea ice cover were also obtained. In strong thermoclines, the seal-derived data sometimes showed positive biases in salinity with spike-like signal. For these salinity biases, we applied a new thermal mass inertia correction scheme, effectively reducing spurious salinity biases in the seasonal thermocline. In the Soya Strait and the adjacent region, the detailed structure of the Soya Warm Current including the cold-water belt was well identified. Dense water up to 27.0σθ, which can be a potential source of Okhotsk Sea Intermediate Water, has flowed from the Soya Strait into the Sea of Okhotsk in mid-winter (February). In summer, around the Iony Island and Urup Strait, remarkable cold and saline waters are localized in the surface layers. These regions are also characterized by weak stratification, suggesting the occurrence of tidally induced vertical mixing. Thus, CTD-tag observations have a great potential in monitoring data-sparse regions in the Sea of Okhotsk.

  3. Surgery in World War II. Ophthalmology and Otolaryngology

    DTIC Science & Technology

    1957-01-01

    Suirgeonts b~e aissignted to htospitIals to he erected ill advanceed aureas. 5. That optical uinit s be orga Itize inl Ihe vat riotS il oes, wi%% ace tm o1...pmettl v otcludedIt’ glasses wvere niot to be w~ ornl . Usioni of less t han 20/40 if) either e’ve, reqtuiretd the addtitionial exaunihnat ionis just...Maliv wvourld mlerely hrave b~een inI(orVcnI~ieni(,e(l l)Ny I)einir wit liolt grilase tm oaily, buit mally ot her-s would have luecni pail tiallv Or

  4. Performance evaluation of a permanent ring magnet based helicon plasma source for negative ion source research

    NASA Astrophysics Data System (ADS)

    Pandey, Arun; Bandyopadhyay, M.; Sudhir, Dass; Chakraborty, A.

    2017-10-01

    Helicon wave heated plasmas are much more efficient in terms of ionization per unit power consumed. A permanent magnet based compact helicon wave heated plasma source is developed in the Institute for Plasma Research, after carefully optimizing the geometry, the frequency of the RF power, and the magnetic field conditions. The HELicon Experiment for Negative ion-I source is the single driver helicon plasma source that is being studied for the development of a large sized, multi-driver negative hydrogen ion source. In this paper, the details about the single driver machine and the results from the characterization of the device are presented. A parametric study at different pressures and magnetic field values using a 13.56 MHz RF source has been carried out in argon plasma, as an initial step towards source characterization. A theoretical model is also presented for the particle and power balance in the plasma. The ambipolar diffusion process taking place in a magnetized helicon plasma is also discussed.

  5. Performance evaluation of a permanent ring magnet based helicon plasma source for negative ion source research.

    PubMed

    Pandey, Arun; Bandyopadhyay, M; Sudhir, Dass; Chakraborty, A

    2017-10-01

    Helicon wave heated plasmas are much more efficient in terms of ionization per unit power consumed. A permanent magnet based compact helicon wave heated plasma source is developed in the Institute for Plasma Research, after carefully optimizing the geometry, the frequency of the RF power, and the magnetic field conditions. The HELicon Experiment for Negative ion-I source is the single driver helicon plasma source that is being studied for the development of a large sized, multi-driver negative hydrogen ion source. In this paper, the details about the single driver machine and the results from the characterization of the device are presented. A parametric study at different pressures and magnetic field values using a 13.56 MHz RF source has been carried out in argon plasma, as an initial step towards source characterization. A theoretical model is also presented for the particle and power balance in the plasma. The ambipolar diffusion process taking place in a magnetized helicon plasma is also discussed.

  6. Commissioning results of CERN HIE-ISOLDE and INFN ALPI cryogenic control systems

    NASA Astrophysics Data System (ADS)

    Inglese, V.; Pezzetti, M.; Calore, A.; Modanese, P.; Pengo, R.

    2017-02-01

    The cryogenic systems of both accelerators, namely HIE ISOLDE (High Intensity and Energy Isotope Separator On Line DEvice) at CERN and ALPI (Acceleratore Lineare Per Ioni) at LNL, have been refurbished. HIE ISOLDE is a major upgrade of the existing ISOLDE facilities, which required the construction of a superconducting linear accelerator consisting of six cryomodules, each containing five superconductive RF cavities and superconducting solenoids. The ALPI linear accelerator, similar to HIE ISOLDE, is located at Legnaro National Laboratories (LNL) and became operational in the early 90’s. It is composed of 74 superconducting RF cavities, assembled inside 22 cryostats. The new control systems are equipped with PLC, developed on the CERN UNICOS framework, which include Schneider and Siemens PLCs and various fieldbuses (Profibus DP and PA, WorldFIP). The control systems were developed in synergy between CERN and LNL in order to build, effectively and with an optimized use of resources, control systems allowing to enhance ease of operation, maintainability, and long-term availability. This paper describes (i) the cryogenic systems, with special focus on the design of the control systems hardware and software, (ii) the strategy adopted in order to achieve a synergic approach, and (iii) the commissioning results after the cool-down to 4.5 K of the cryomodules.

  7. Design study of a re-bunching RFQ for the SPES project

    NASA Astrophysics Data System (ADS)

    Shin, Seung Wook; Palmieri, A.; Comunian, M.; Grespan, F.; Chai, Jong Seo

    2014-05-01

    An upgrade to the 2nd generation of the selective production of exotic species (SPES) to produce a radioactive ion beam (RIB) has been studied at the istituto nazionale di fisica nucleare — laboratory nazionali di Legnaro (INFN-LNL). Due to the long distance between the isotope separator online (ISOL) facility and the superconducting quarter wave resonator (QWR) cavity acceleratore lineare per ioni (ALPI), a new re-buncher cavity must be introduced to maintain the high beam quality during the beam transport. A particular radio frequency quadrupole (RFQ) structure has been suggested to meet the requirements of this project. A window-type RFQ, which has a high mode separation, less power dissipation and compact size compared to the conventional normal 4-vane RFQ, has been introduced. The RF design has been studied considering the requirements of the re-bunching machine for high figures of merit such as a proper operation frequency, a high shunt impedance, a high quality factor, a low power dissipation, etc. A sensitivity analysis of the fabrication and the misalignment error has been conducted. A micro-movement slug tuner has been introduced to compensate for the frequency variations that may occur due to the beam loading, the thermal instability, the microphonic effect, etc.

  8. Structural manipulation approaches towards enhanced sodium ionic conductivity in Na-rich antiperovskites

    DOE PAGES

    Wang, Yonggang; Wang, Qingfei; Liu, Zhenpu; ...

    2015-06-10

    High-performance solid electrolytes are critical for realizing all-solid-state batteries with enhance safety and cycling efficiency. However, currently available candidates (sulfides and the NASICON-typ ceramics) still suffer from drawbacks such as inflammability, high-cost and unfavorable machinability Here we present the structural manipulation approaches to improve the sodium ionic conductivity in series of affordable Na-rich antiperovskites. Experimentally, the whole solid solutions of Na 3OX (X ¼ Cl Br, I) are synthesized via a facile and timesaving route from the cheapest raw materials (Na, NaOH an NaX). The materials are nonflammable, suitable for thermoplastic processing due to low melting temperature (<300° C) withoutmore » decomposing. Notably, owing to the flexibility of perovskite-type structure it's feasible to control the local structure features by means of size-mismatch substitution an unequivalent-doping for a favorable sodium ionic diffusion pathway. Enhancement of sodium ioni conductivity by 2 magnitudes is demonstrated by these chemical tuning methods. The optimized sodiu ionic conductivity in Na 2.9Sr 0.05OBr 0.6I 0.4 bulk samples reaches 1.9 10 - 3 S/cm at 200° C and even highe at elevated temperature. Here, we believe further chemical tuning efforts on Na-rich antiperovskites wil promote their performance greatly for practical all-solid state battery applications.« less

  9. Uv Spectroscopy of Low-Redshift Active Galaxies -- Cyc 4

    NASA Astrophysics Data System (ADS)

    Boggess, Albert

    1994-01-01

    FOS will be used to measure the ultraviolet spectrum of active galaxies. Complementary and simultaneous visual and infrared data will also be obtained. The profile of the emission lines will provide information on the broadening mechanism and dynamics of the emitting regions. Comparison of the profile and radial velocity of the emission lines produced by species of different ioni- zation potential will allow the study of the thermal and density stratification of the emitting regions. The degree of asymmetry of lines at different wave- lengths will allow the absorbing material be identified and located. The ratio of the UV to visible lines, such as those for O I and He II will be used to estimate the reddening along the line of sight. Ratio of emission line fluxes will be compared with models in order to derive the ionization mechanism, elec- tron temperature and density, and chemical composition of the emitting gas. The emission line properties of low luminosity will be compared with those of high luminosity objects in order to investigate the covering factor and evolutionary effects. The continumm spectrum from the UV to the IR will be used to establish the emission mechanism and the nature and luminosity of the energy source. The weak absorption lines will be used to establish the physical conditions and the chemical composition of the gas in: our Galaxy, intergalactic medium and the parent galaxy. Absorption produced by broad line clouds will give information on cloud motion and covering factor.

  10. Direct Observations of Interstellar H, He, and O by the Interstellar Boundary Explorer (Invited)

    NASA Astrophysics Data System (ADS)

    Moebius, E.; Bochsler, P. A.; Bzowski, M.; Crew, G. B.; Funsten, H. O.; Fuselier, S. A.; Ghielmetti, A.; Heirtzler, D.; Izmodenov, V.; Kubiak, M.; Kucharek, H.; Lee, M. A.; Leonard, T.; McComas, D. J.; Petersen, L.; Saul, L. A.; Scheer, J.; Schwadron, N. A.; Witte, M.; Wurz, P.

    2009-12-01

    Due to the motion of the Sun relative to its neighborhood, the neutral gas of the local in-terstellar medium (LISM) flows through the inner heliosphere where it is subject to ioni-zation, the Sun’s gravity, and radiation pressure. Observing the resulting spatial distribu-tion and flow pattern of several interstellar gas species with UV backscatter, pickup ion, and neutral atom imaging techniques allows us to unravel the physical conditions of the LISM and its interaction with the heliosphere. Imaging of the neutral gas flow directly with energetic neutral atom (ENA) cameras yields the most accurate account of the ki-netic parameters of the interstellar gas, but so far this has been carried out only for He using Ulysses GAS. IBEX, which was launched in October 2008, provides the capability for simultaneous flow observations of several interstellar species with its triple-time-of-flight IBEX-Lo sensor. Because H and O are strongly affected by the heliospheric inter-face while He is not, a direct comparison between these species enables an independent assessment of the slowdown and heating processes in the outer heliosheath. Likewise, IBEX observations will constrain models of the heliospheric interaction and provide a test of the heliospheric asymmetry - recently inferred from Voyager and SOHO SWAN observations - that is seen as an indicator for the interstellar magnetic field direction. During the first half year of its mission IBEX has observed the interstellar He, O, and H flow. We will present an overview and preliminary analysis of these first interstellar mul-tispecies scans of the interstellar gas flow in spring and fall 2009.

  11. Electromembrane recycling of highly mineralized alkaline blowdown water from evaporative water treatment plants at thermal power stations

    NASA Astrophysics Data System (ADS)

    Chichirova, N. D.; Chichirov, A. A.; Lyapin, A. I.; Minibaev, A. I.; Silov, I. Yu.; Tolmachev, L. I.

    2016-12-01

    Thermal power stations (TPS) are the main source of highly mineralized effluents affecting the environment. An analysis of their water systems demonstrates that alkaline effluents prevail at TPSs. Extraction of an alkali from highly mineralized effluents can make the recycling of effluents economically feasible. A method is proposed of electromembrane recycling of liquid alkaline highly mineralized wastes from TPSs. The process includes electromembrane apparatuses of two types, namely, a diffusion dialysis extractor (DDE) intended for extraction of the alkali from a highly mineralized solution having a complex composition and an electrodialysis concentrator for increasing the concentration of the extracted solution to a value suitable for use in water treatment plants at TPSs. For implementation of the first process (i.e. the extraction of alkali from alkaline-salt solution) various membranes from various manufacturers were studied: CM-PAD and AM-PAD (Ralex, Czechia), MK-40, MA-40, MA-41, MA-414, and MB-2 (OOO OKhK "Shchekinoazot", Russia), AR103-QDF and CR61-CMP (Ionies Inc., USA). The experiments demonstrate that the acceptable degree of separation of the alkali and the salt is achieved in a pair of cation-exchange membranes with the efficiency of separation being higher without an electric field. The highest efficiency was attained with Russian-made membranes (MK-40, OOO OKhK "Shchekinoazot"). A full scale experiment on recycling of highly-mineralized blowdown water from the evaporating water treatment system at the Kazan cogeneration power station No. 3 (TETs-3) was performed in a pilot unit consisting of two electromembrane apparatuses made by UAB "Membraninės Technologijos LT". In the experiments every ton of blowdown water yielded 0.1 t of concentrated alkaline solution with an alkali content of up to 4 wt % and 0.9 t of the softened salt solution suitable for the reuse in the TPS cycle. The power rate is 6 kWh / ton of blowdown water.

  12. X-Ray Emission from Supernova Remnants.

    NASA Astrophysics Data System (ADS)

    Sackville Hamilton, Andrew James

    1984-12-01

    This thesis deals with the x-ray spectra of supernova remnants (SNRs), and in particular the x-ray spectra of the two young Type I SNRs SN1006 and Tycho. Firstly an extensive grid of nonequilibrium model spectra of SNRs in the adiabatic blast wave stage of evolution is computed, and numerous diagnostics of the state and composi- tion of the blast wave plasma are plotted over parameter space. It is demonstrated that the spectrum of an adiabatic blast wave is a good approximation to several other model SNR structures in which emission is dominated by gas undergoing quasi steady state ioni- zation near a shock front, including the one-fluid isothermal blast wave similarity solution, and the reverse shock similarity solution advocated by Chevalier for the early evolution of Type I SNe. None of these structures appears able to account for the observed spectra of SN1006 or Tycho. A new similarity solution for the early time evolution of uniform ejecta moving into an external medium is presented. It is argued that the x-ray spectra of SN1006 and Tycho are consistent with emission mainly from a reverse shock into 1.4M(,o) of initially uniform density SN ejecta consisting of pure heavy elements, moving into a uniform medium. Satisfactory fits to the observed spectra are obtained with a two layer structure of ejecta, an outer layer of unprocessed material, and an inner layer of mixed processed heavy elements. The structure of ejecta inferred is similar for both SN1006 and Tycho, the marked difference between the two spectra being attributed largely to the lower density of the ambient medium around SN1006. The results are consistent with the theory of Type I SNe as exploded white dwarfs, and resolve the apparent problems of too little iron, and too much total mass, deduced by other authors from earlier analyses of the x-ray emission of SN1006 and Tycho. Various salient aspects of the physics of a shock-heated pure heavy element plasma are discussed.

  13. The Origin of the Terra Meridiani Sediments: Volatile Transport and the Formation of Sulfate Bearing Layered Deposits on Mars

    NASA Technical Reports Server (NTRS)

    Niles, P.B.

    2008-01-01

    The chemistry, sedimentology, and geology of the Meridiani sedimentary deposits are best explained by eolian reworking of the sublimation residue of a large scale ice/dust deposit. This large ice deposit was located in close proximity to Terra Meridiani and incorporated large amounts of dust, sand, and SO2 aerosols generated by impacts and volcanism during early martian history. Sulfate formation and chemical weathering of the initial igneous material is hypothesized to have occurred inside of the ice when the darker mineral grains were heated by solar radiant energy. This created conditions in which small films of liquid water were created in and around the mineral grains. This water dissolved the SO2 and reacted with the mineral grains forming an acidic environment under low water/rock conditions. Subsequent sublimation of this ice deposit left behind large amounts of weathered sublimation residue which became the source material for the eolian process that deposited the Terra Meridiani deposit. The following features of the Meridiani sediments are best explained by this model: The large scale of the deposit, its mineralogic similarity across large distances, the cation-conservative nature of the weathering processes, the presence of acidic groundwaters on a basaltic planet, the accumulation of a thick sedimentary sequence outside of a topographic basin, and the low water/rock ratio needed to explain the presence of very soluble minerals and elements in the deposit. Remote sensing studies have linked the Meridiani deposits to a number of other martian surface features through mineralogic similarities, geomorphic similarities, and regional associations. These include layered deposits in Arabia Terra, interior layered deposits in the Valles Marineris system, southern Elysium/Aeolis, Amazonis Planitia, and the Hellas basin, Aram Chaos, Aureum Chaos, and Ioni Chaos. The common properties shared by these deposits suggest that all of these deposits share a common

  14. Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy.

    PubMed

    Mercuri, Eugenio; Darras, Basil T; Chiriboga, Claudia A; Day, John W; Campbell, Craig; Connolly, Anne M; Iannaccone, Susan T; Kirschner, Janbernd; Kuntz, Nancy L; Saito, Kayoko; Shieh, Perry B; Tulinius, Már; Mazzone, Elena S; Montes, Jacqueline; Bishop, Kathie M; Yang, Qingqing; Foster, Richard; Gheuens, Sarah; Bennett, C Frank; Farwell, Wildon; Schneider, Eugene; De Vivo, Darryl C; Finkel, Richard S

    2018-02-15

    clinically meaningful improvement in motor function as compared with those in the control group. (Funded by Biogen and Ionis Pharmaceuticals; CHERISH ClinicalTrials.gov number, NCT02292537 .).

  15. Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides.

    PubMed

    Graham, Mark J; Lee, Richard G; Brandt, Teresa A; Tai, Li-Jung; Fu, Wuxia; Peralta, Raechel; Yu, Rosie; Hurh, Eunju; Paz, Erika; McEvoy, Bradley W; Baker, Brenda F; Pham, Nguyen C; Digenio, Andres; Hughes, Steven G; Geary, Richard S; Witztum, Joseph L; Crooke, Rosanne M; Tsimikas, Sotirios

    2017-07-20

    mice. Use of the same strategy to target human ANGPTL3 reduced levels of atherogenic lipoproteins in humans. (Funded by Ionis Pharmaceuticals; ClinicalTrials.gov number, NCT02709850 .).

  16. Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy.

    PubMed

    Finkel, Richard S; Mercuri, Eugenio; Darras, Basil T; Connolly, Anne M; Kuntz, Nancy L; Kirschner, Janbernd; Chiriboga, Claudia A; Saito, Kayoko; Servais, Laurent; Tizzano, Eduardo; Topaloglu, Haluk; Tulinius, Már; Montes, Jacqueline; Glanzman, Allan M; Bishop, Kathie; Zhong, Z John; Gheuens, Sarah; Bennett, C Frank; Schneider, Eugene; Farwell, Wildon; De Vivo, Darryl C

    2017-11-02

    nusinersen. The incidence and severity of adverse events were similar in the two groups. Among infants with spinal muscular atrophy, those who received nusinersen were more likely to be alive and have improvements in motor function than those in the control group. Early treatment may be necessary to maximize the benefit of the drug. (Funded by Biogen and Ionis Pharmaceuticals; ENDEAR ClinicalTrials.gov number, NCT02193074 .).

  17. The Development of III-V Semiconductor MOSFETs for Future CMOS Applications

    NASA Astrophysics Data System (ADS)

    Greene, Andrew M.

    ,500 and sub-threshold swing = 340 mV/dec. Split C-V measurements were used to extract an effective channel mobility of muh* = 300 cm2/Vs at Ns = 2 x 1012 cm -2. "Gate-last" MOSFETs grown with an epitaxial p + contact layer were fabricated using selective gate-recess etching techniques. A parasitic "n-channel" limited ION/I OFF ratio and sub-threshold swing, most likely due to effects from the InAs surface layer.

  18. Etude du champ magnetique dans les nuages moleculaires

    NASA Astrophysics Data System (ADS)

    Houde, Martin

    2001-12-01

    Ce travail est une étude du champ magnétique duns l'environnement circumstellaire des étoiles jeunes. Il a pour origine la certitude qu'avait l'auteur qu'il se devait d'être possible de détecter la présence d'un champ magnétique, et de possiblement le caractériser, par le biais d'observations de profils spectraux d'espèces moléculaires ioniques. Il en découle donc qu'un des buts principaux était de prouver que cela est effectivement possible. La thèse comporte alors des éléments théoriques et expérimentaux qui sont à la fois complémentaires et intimement liés. L'aspect théorique est basé sur l'interaction mutuelle que des particules neutres et chargées peuvent avoir l'une sur l'autre daps un plasma faiblement ionisé comme ceux existants daps les nuages moléculaires sites de formation stellaire. Il appert que la présence d'un champ magnétique a un effet direct sur le comportement des ions (via la force de Lorentz) et indirect sur les molécules neutres (via les nombreuses collisions entre les deux types de particules). Une telle interaction est, comme il est maintenant bien connu, présente dans les premières étapes de la formation dune étoile. Il s'agit bien sûr de la diffusion ambipolaire. Nous montrerons qu'il existe cependant un autre type de diffusion, jusqu'ici inconnue, qui se manifeste plus tard au tours de l'évolution des nuages moléculaires. Celle-ci peut avoir un effet dramatique sur l'apparence des profils spectraux (de rotation moléculaire) des espèces ioniques lorsque comparés à ceux qu'exhibent des espèces neutres coexistantes. Mais pour ce faire, il doit y avoir existence de mouvements organisés (des flots ou jets) de matière ou encore la présence de turbulence dans les régions considérées. Une distribution de vélocité du type maxwellienne ne révèlera pas la présence du champ magnétique. Les observations, qui ont pour but de confirmer la théorie, se situent dans le domaine des longueurs d

  19. A Systematic Review of PCSK9 Inhibitors Alirocumab and Evolocumab.

    PubMed

    McDonagh, Marian; Peterson, Kim; Holzhammer, Brittany; Fazio, Sergio

    2016-06-01

    statins, and patients with varied CV risk not at LDL-C goal with statin therapy. The highest strength evidence was for heterozygous familial hypercholesterolemia and patients not at LDL-C goals. Moderate-strength evidence showed HDL-C increases in the range of 4.5%-6.8%. Harms were not different between groups, except possibly slightly greater overall adverse event reporting. Evidence on adjudicated CV outcomes was insufficient to draw conclusions because of sparseness of events, study limitations, and inability to assess consistency of findings. Alirocumab and evolocumab have evidence of large improvements in lipid levels. The strength of the evidence is greater for alirocumab than evolocumab in patients with high CV risk who were not at LDL-C target goals, while evidence for evolocumab is stronger in patients with heterogeneous familial hypercholesterolemia and patients with varied CV risk who were not at LDL-C target goals. Evidence on adjudicated CV outcomes for a priori analyses is unable to show benefit for alirocumab and is insufficient to draw conclusions for evolocumab. Important questions remain about the comparative effects on long-term health outcomes. This project was funded by The Drug Effectiveness Review Project. Project participants reviewed the manuscript but had no role in conducting the work or writing the manuscript. Any comments received from the participants during the course of the review were taken at the discretion of the authors independently. All authors had access to the data and a role in writing the manuscript. McDonagh, Peterson, and Holzhammer declare no conflict of interest or financial interest in any therapy discussed in this article. Fazio declares receiving compensation from Sanofi for a presentation on his science to a group of their advisors and has served as a consultant to MSD, BASF, NHP, Sanofi, Ionis Pharmaceuticals, and Kowa. Study concept and design were primarily contributed by McDonagh, along with Peterson and Holzhammer

  20. Electrical and Optical Characterization of Nanowire based Semiconductor Devices

    NASA Astrophysics Data System (ADS)

    Ayvazian, Talin

    This research project is focused on a new strategy for the creation of nanowire based semiconductor devices. The main goal is to understand and optimize the electrical and optical properties of two types of nanoscale devices; in first type lithographically patterned nanowire electrodeposition (LPNE) method has been utilized to fabricate nanowire field effect transistors (NWFET) and second type involved the development of light emitting semiconductor nanowire arrays (NWLED). Field effect transistors (NWFETs) have been prepared from arrays of polycrystalline cadmium selenide (pc-CdSe) nanowires using a back gate configuration. pc-CdSe nanowires were fabricated using the lithographically patterned nanowire electrode- position (LPNE) process on SiO2 /Si substrates. After electrodeposition, pc-CdSe nanowires were thermally annealed at 300 °C x 4 h either with or without exposure to CdCl 2 in methanol a grain growth promoter. The influence of CdCl2 treatment was to increase the mean grain diameter as determined by X-ray diffraction pattern and to convert the crystal structure from cubic to wurtzite. Transfer characteristics showed an increase of the field effect mobility (mu eff) by an order of magnitude and increase of the Ion/I off ratio by a factor of 3-4. Light emitting devices (NW-LED) based on lithographically patterned pc-CdSe nanowire arrays have been investigated. Electroluminescence (EL) spectra of CdSe nanowires under various biases exhibited broad emission spectra centered at 750 nm close to the band gap of CdSe (1.7eV). To enhance the intensity of the emitted light and the external quantum efficiency (EQE), the distance between the contacts were reduced from 5 mum to less than 1 mum which increased the efficiency by an order of magnitude. Also, increasing the annealing temperature of nanowires from 300 °C x4 h to 450 This research project is focused on a new strategy for the creation of nanowire based semiconductor devices. The main goal is to understand

  1. Etude de la variabilite des etoiles massives a l'aide de la photometrie et la spectroscopie

    NASA Astrophysics Data System (ADS)

    Lefevre, Laure

    Les étoiles Wolf-Rayet (WR) de population I sont les descendants évolués des étoiles massives de type O. Elles présentent de larges raies en émission produites par des atomes ionisés qui forment le vent stellaire chaud, den se et rapide. Il y a deux classes principales d'étoiles WR: les WN, ou les raies de l'azote dominent, et les WC (WO) ou les raies du carbone (de l'oxygène) dominent. Des observations récentes ont révelé que les vents sont "fragmentés" à petite et grande échelle, ce qui pourrait être relié en partie à des petites surdensités situées dans le vent en expansion. Cette thèse de doctorat présente la détection, l'analyse et l'interprétation, avec des outils statistiques avancés, de la variabilité dans les courbes de lumière, les vitesses radiales, et les spectres de deux étoiles WR caractéristiques (WR137 et WR123) et dans les étoiles OB observées par le satellite HIPPARCOS. Une campagne de spectroscopie intensive a été réalisée en 1999-2000 pour améliorer notre connaissance des composantes orbitales de WR137 (WC7pd+O9) et étudier les vents des WR et les conditions de formation des poussières dans de tels milieux. Le premier volet de cette thèse a permis de déduire de ces observations une orbite spectroscopique d'environ 13 ans qui confirme et précise les précédents résultats. Grace à l'analyse des spectres de cette campagne, ce travail a mis à jour une deuxième période d'oscillation de très faible amplitude de 0.83 j dans les spectres de WR137. Celle-ci pourrait être reliée aux pulsations ou à de grandes structures qui tourneraient dans le vent comme dans l'étoile EZ CMa (WR6). Une analyse en ondelettes a également permis d'isoler et de suivre pendant plusieurs heures des structures en haut des raies de CIII et CIV dans le spectre de WR137. De plus, la corrélation croisée a permis de voir que les raies formées à différentes distances de l'étoile sont probablement reliées entre elles. Enfin l