Sample records for tau decay tau

  1. Tau Decays in Pythia 8

    E-print Network

    Ilten, Philip

    2012-01-01

    As of version 8.150 of Pythia, the isotropic decay model of tau-leptons has been replaced with sophisticated tau-lepton decay machinery. The decays and spin correlations for tau-leptons in Pythia 8 are described, including the spin correlation algorithm, the available tau-lepton production processes, the tau-lepton decay models, the user interface, and the implementation.

  2. Upper limit on the nu tau mass from tau --> 3 hnu tau decays

    Microsoft Academic Search

    Gideon Alexander; J. Allison; N. Altekamp; K A Ametewee; K. J. Anderson; S. Anderson; S. Arcelli; S. Asai; D A Axen; Georges Azuelos; A. H. Ball; E. Barberio; R. J. Barlow; R. Bartoldus; J Richard Batley; G. Beaudoin; J. Bechtluft; C. Beeston; T. Behnke; A. N. Bell; K. W. Bell; G. Bella; Stanislaus Cornelius Maria Bentvelsen; P. Berlich; Siegfried Bethke; O. Biebel; Volker Blobel; Ian J Bloodworth; J. E. Bloomer; P. Bock; H. M. Bosch; M. Boutemeur; B. T. Bouwens; S. Braibant; P G Bright-Thomas; R. M. Brown; Helfried J Burckhart; C. Burgard; R. Bürgin; P. Capiluppi; R. K. Carnegie; A. A. Carter; J. R. Carter; C. Y. Chang; C. Charlesworth; D. G. Charlton; D. Chrisman; S. L. Chu; P. E. L. Clarke; I. Cohen; J. E. Conboy; O. C. Cooke; M. Cuffiani; S. Dado; C. Dallapiccola; G. M. Dallavalle; C L Darling; S. de Jong; L. A. Del Pozo; M. S. Dixit; E. Do Couto E Silva; M. Doucet; E. Duchovni; G. Duckeck; I. P. Duerdoth; J. E. G. Edwards; P. G. Estabrooks; H. G. Evans; M. Evans; Franco Luigi Fabbri; P. Fath; F. Fiedler; M. Fierro; H. M. Fischer; R. Folman; D. G. Fong; M. Foucher; H. Fukui; A. Fürtjes; P. Gagnon; A. Gaidot; J. W. Gary; J. Gascon; S. M. Gascon-Shotkin; N. I. Geddes; C. Geich-Gimbel; S. W. Gensler; F. X. Gentit; T. Geralis; G. Giacomelli; P. Giacomelli; R. Giacomelli; V. Gibson; W. R. Gibson; D. M. Gingrich; J. Goldberg; M. J. Goodrick; W. Gorn; C. Grandi; E. Gross; M. Gruwé; C. Hajdu; G. G. Hanson; M. Hansroul; M. Hapke; C. K. Hargrove; P. A. Hart; C. Hartmann; M. Hauschild; C. M. Hawkes; R. Hawkings; Richard J Hemingway; G. Herten; R. D. Heuer; M. D. Hildreth; J. C. Hill; S. J. Hillier; T. Hilse; P. R. Hobson; R James Homer; A. K. Honma; D. Horváth; R. Howard; R. E. Hughes-Jones; D. E. Hutchcroft; P. Igo-Kemenes; D. C. Imrie; M. R. Ingram; A. Jawahery; P. W. Jeffreys; H. Jeremie; Martin Paul Jimack; A. Joly; G. Jones; M. Jones; R. W. L. Jones; U. Jost; P. Jovanovic; J I Kanzaki; D A Karlen; T. Kawamoto; Richard K Keeler; R. G. Kellogg; B. W. Kennedy; J. King; J. Kirk; S. Kluth; T. Kobayashi; M. Kobel; D. S. Koetke; T. P. Kokott; S. Komamiya; R V Kowalewski; T. Kress; P. Krieger; J. von Krogh; P. Kyberd; G. D. Lafferty; H. Lafoux; R. Lahmann; W. P. Lai; D. Lanske; J. Lauber; J. G. Layter; A. M. Lee; E. Lefebvre; Daniel Lellouch; J. Letts; L. Levinson; C. Lewis; S. L. Lloyd; F. K. Loebinger; G. D. Long; B. Lorazo; Michael J Losty; J. Ludwig; A. Luig; A. Malik; M. Mannelli; S. Marcellini; C. Markus; A. J. Martin; J. P. Martin; G. Martinez; T. Mashimo; W. Matthews; P. Mättig; W. J. McDonald; J A McKenna; E. A. McKigney; T. J. McMahon; A. I. McNab; F. Meijers; S. Menke; F. S. Merritt; H. Mes; J. Meyer; Aldo Michelini; G. Mikenberg; D. J. Miller; R. Mir; W. Mohr; A. Montanari; T. Mori; M. Morii; U. Müller; B. Nellen; B. Nijjhar; R. Nisius; S. W. O'Neale; F. G. Oakham; F. Odorici; H. O. Ogren; T. Omori; M. J. Oreglia; S. Orito; M. Palazzo; J. Pálinkás; J. P. Pansart; G. Pásztor; J. R. Pater; G. N. Patrick; M. J. Pearce; S. Petzold; J. E. Pilcher; J L Pinfold; D. E. Plane; P R Poffenberger; B. Poli; A. Posthaus; H. Przysiezniak; D. L. Rees; D. Rigby; M. G. Rison; S. A. Robins; N L Rodning; J. M. Roney; A M Rooke; E. Ros; A. M. Rossi; M. Rosvick; P. Routenburg; Y. Rozen; K. Runge; O. Runolfsson; D. R. Rust; R. Rylko; E Sarkisyan-Grinbaum; M. Sasaki; C. Sbarra; A. D. Schaile; O. Schaile; F. Scharf; P. Scharff-Hansen; P. Schenk; B. Schmitt; M. Schröder; H. C. Schultz-Coulon; M. Schulz; P. Schütz; J. Schwiening; W. G. Scott; T. G. Shears; B. C. Shen; C. H. Shepherd-Themistocleous; P. Sherwood; G. P. Siroli; A. Sittler; A. Skillman; A. Skuja; A. M. Smith; T. J. Smith; G. A. Snow; Randall J Sobie; S. Söldner-Rembold; R. W. Springer; M. Sproston; A. Stahl; M. Starks; K. Stephens; J. Steuerer; B. Stockhausen; D. Strom; F. Strumia; P. Szymanski; R. Tafirout; H. Takeda; P. Taras; S. Tarem; M. Tecchio; N. Tesch; M. Thiergen; M. A. Thomson; E. von Törne; S. Towers; M. Tscheulin; E. Tsur; A. S. Turcot; M. F. Turner-Watson; P. Utzat; R. van Kooten; G. Vasseur; M. Verzocchi; P. Vikas; M G Vincter; E. H. Vokurka; F. Wäckerle; A. Wagner; C. P. Ward; D. R. Ward; J. J. Ward; P. M. Watkins; A. T. Watson; N. K. Watson; P. Weber; P. S. Wells; N. Wermes; J. S. White; B. Wilkens; G. W. Wilson; J. A. Wilson; T. Wlodek; G. Wolf; S A Wotton; T. R. Wyatt; S M Xella; S. Yamashita; G. Yekutieli; K. Yoshimura; V. Zacek

    1996-01-01

    A new technique has been used to determine a limit on the nu tau mass using Z0--> tau + tau - events selected from 140 pb-1 of data collected with the OPAL detector at LEP during the period 1990-1994. Using Z0--> tau + tau - events in which both tau-leptons decay to three charged particles, a novel likelihood analysis is

  3. First observation of tau->3 pi eta nu(tau) and tau->f(1)pi nu(tau) decays

    E-print Network

    Ammar, Raymond G.; Baringer, Philip S.; Bean, Alice; Besson, David Zeke; Coppage, Don; Darling, C.; Davis, Robin E. P.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, Nowhan

    1997-09-01

    We have observed new channels for tau decays with an eta in the final state. We study 3-prong tau decays, using the eta --> gamma gamma and eta --> 3 pi(0) decay modes and 1-prong decays with two pi(0)'s using the eta --> ...

  4. Improved measurement of $\\psi (2S)$ decays into $\\tau ^{+}\\tau ^{-}$

    E-print Network

    Ablikim, M; Ban, Y; Bian, J G; Cai, X; Chen, H F; Chen, H S; Chen, H X; Chen, J C; Jin, C; Chen, Y B; Chi, S P; Chu, Y P; Cui, X Z; Dai, Y S; Diao, L Y; Deng, Z Y; Dong, Q F; Du, S X; Fang, J; Fang, S S; Fu, C D; Gao, C S; Gao, Y N; Gu, S D; Gu, Y T; Guo, Y N; Guo, Y Q; Guo, Z J; Harris, F A; He, K L; He, M; Heng, Y K; Hu, H M; Hu, T; Huang, G S; Huang, X T; Ji, X B; Jiang, X S; Jiang, X Y; Jiao, J B; Jin, D P; Jin, S; Yi, J; Lai, Y F; Li, G; Li, H B; Li, H H; Li, J; Li, R Y; Li, S M; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, Y L; Liang, Y F; Liao, H B; Liu, B J; Liu, C X; Liu, F; Fang, L; Liu, H H; Liu, H M; Liu, J; Liu, J B; Liu, J P; Liu, Q; Liu, R G; Liu, Z A; Lou, Y C; Lu, F; Lu, G R; Lu, J G; Luo, C L; Ma, F C; Ma, H L; Ma, L L; Ma, Q M; Ma, X B; Mao, Z P; Mo, X H; Nie, J; Olsen, S L; Peng, H P; Ping, R G; Qi, N D; Qin, H; Qiu, J F; Ren, Z Y; Rong, G; Shan, L Y; Shang, L; Shen, C P; Shen, D L; Shen, X Y; Sheng, H Y; Sun, H S; Sun, J F; Sun, S S; Sun, Y Z; Sun, Z J; Tan, Z Q; Tang, X; Tong, G L; Varner, G S; Wang, D Y; Wang, L; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, W F; Wang, Y F; Wang, Z; Wang, Z Y; Zhe, W Z W; Wei, C L; Wei, D H; Wu, N; Xia, X M; Xie, X X; Xu, G F; Xu, X P; Xu, Y; Yan, M L; Yang, H X; Yang, Y X; Ye, M H; Ye, Y X; Yi, Z Y; Yu, G W; Yuan, C Z; Yuan, J M; Yuan, Y; Zang, S L; Zeng, Y; Zhang, B X; Zhang, B Y; Zhang, C C; Zhang, D H; Zhang, H Q; Zhang, H Y; Zhang, J W; Zhang, J Y; Zhang, S H; Zhang, X M; Zhang, X Y; Yiyun, Z; Zhang, Z P; Zhao, D X; Zhao, J W; Zhao, M G; Zhao, P P; Zhao, W R; Zhao, Z G; Zheng, H Q; Zheng, J P; Zheng, Z P; Zhou, L; Zhou, N F; Zhu, K J; Zhu, Q M; Zhu, Y C; Zhu, Y S; Yingchun, Z; Zhu, Z A; Zhuang, B A; Zhuang, X A; Zou, B S

    2006-01-01

    Using 14M $\\psi (2S)$ events collected at BESII, the branching fraction of $\\psi (2S)\\to \\tau ^{+}\\tau ^{-}$ is measured to be $Br_{\\tau \\tau}=(3.10\\pm 0.21\\pm 0.38)\\times 10^{-3}$, where the first error is statistical and the second is systematic.

  5. Observation of the Semileptonic Decays B>D*tau-nu¯tau and Evidence for B>Dtau-nu¯tau

    Microsoft Academic Search

    B. Aubert; M. Bona; D. Boutigny; Y. Karyotakis; J. P. Lees; V. Poireau; X. Prudent; V. Tisserand; A. Zghiche; J. Garra Tico; E. Grauges; L. Lopez; A. Palano; M. Pappagallo; G. Eigen; B. Stugu; L. Sun; G. S. Abrams; M. Battaglia; D. N. Brown; J. Button-Shafer; R. N. Cahn; Y. Groysman; R. G. Jacobsen; J. A. Kadyk; L. T. Kerth; Yu. G. Kolomensky; G. Kukartsev; D. Lopes Pegna; G. Lynch; L. M. Mir; T. J. Orimoto; I. L. Osipenkov; M. T. Ronan; K. Tackmann; T. Tanabe; W. A. Wenzel; P. Del Amo Sanchez; C. M. Hawkes; A. T. Watson; H. Koch; T. Schroeder; D. Walker; D. J. Asgeirsson; T. Cuhadar-Donszelmann; B. G. Fulsom; C. Hearty; T. S. Mattison; J. A. McKenna; M. Barrett; A. Khan; M. Saleem; L. Teodorescu; V. E. Blinov; A. D. Bukin; V. P. Druzhinin; V. B. Golubev; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; K. Yu. Todyshev; M. Bondioli; S. Curry; I. Eschrich; D. Kirkby; A. J. Lankford; P. Lund; M. Mandelkern; E. C. Martin; D. P. Stoker; S. Abachi; C. Buchanan; J. W. Gary; F. Liu; O. Long; B. C. Shen; G. M. Vitug; L. Zhang; H. P. Paar; S. Rahatlou; V. Sharma; J. W. Berryhill; C. Campagnari; A. Cunha; B. Dahmes; T. M. Hong; D. Kovalskyi; J. D. Richman; T. W. Beck; A. M. Eisner; C. J. Flacco; C. A. Heusch; J. Kroseberg; W. S. Lockman; T. Schalk; B. A. Schumm; A. Seiden; M. G. Wilson; L. O. Winstrom; E. Chen; C. H. Cheng; F. Fang; D. G. Hitlin; I. Narsky; T. Piatenko; F. C. Porter; R. Andreassen; G. Mancinelli; B. T. Meadows; K. Mishra; M. D. Sokoloff; F. Blanc; P. C. Bloom; S. Chen; W. T. Ford; J. F. Hirschauer; A. Kreisel; M. Nagel; U. Nauenberg; A. Olivas; J. G. Smith; K. A. Ulmer; S. R. Wagner; J. Zhang; A. M. Gabareen; A. Soffer; W. H. Toki; R. J. Wilson; F. Winklmeier; D. D. Altenburg; E. Feltresi; A. Hauke; H. Jasper; J. Merkel; A. Petzold; B. Spaan; K. Wacker; V. Klose; M. J. Kobel; H. M. Lacker; W. F. Mader; R. Nogowski; J. Schubert; K. R. Schubert; R. Schwierz; J. E. Sundermann; A. Volk; D. Bernard; G. R. Bonneaud; E. Latour; V. Lombardo; Ch. Thiebaux; M. Verderi; P. J. Clark; W. Gradl; F. Muheim; S. Playfer; A. I. Robertson; J. E. Watson; Y. Xie; M. Andreotti; D. Bettoni; C. Bozzi; R. Calabrese; A. Cecchi; G. Cibinetto; P. Franchini; E. Luppi; M. Negrini; A. Petrella; L. Piemontese; E. Prencipe; V. Santoro; F. Anulli; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; G. Finocchiaro; S. Pacetti; P. Patteri; I. M. Peruzzi; M. Piccolo; M. Rama; A. Zallo; A. Buzzo; R. Contri; M. Lo Vetere; M. M. Macri; M. R. Monge; S. Passaggio; C. Patrignani; E. Robutti; A. Santroni; S. Tosi; K. S. Chaisanguanthum; M. Morii; J. Wu; R. S. Dubitzky; J. Marks; S. Schenk; U. Uwer; D. J. Bard; P. D. Dauncey; R. L. Flack; J. A. Nash; W. Panduro Vazquez; M. Tibbetts; P. K. Behera; X. Chai; M. J. Charles; U. Mallik; J. Cochran; H. B. Crawley; L. Dong; V. Eyges; W. T. Meyer; S. Prell; E. I. Rosenberg; A. E. Rubin; Y. Y. Gao; A. V. Gritsan; Z. J. Guo; C. K. Lae; A. G. Denig; M. Fritsch; G. Schott; N. Arnaud; J. Béquilleux; A. D'Orazio; M. Davier; G. Grosdidier; A. Höcker; V. Lepeltier; F. Le Diberder; A. M. Lutz; S. Pruvot; S. Rodier; P. Roudeau; M. H. Schune; J. Serrano; V. Sordini; A. Stocchi; L. Wang; W. F. Wang; G. Wormser; D. J. Lange; D. M. Wright; I. Bingham; J. P. Burke; C. A. Chavez; J. R. Fry; E. Gabathuler; R. Gamet; D. E. Hutchcroft; D. J. Payne; K. C. Schofield; C. Touramanis; A. J. Bevan; K. A. George; F. di Lodovico; R. Sacco; G. Cowan; H. U. Flaecher; D. A. Hopkins; S. Paramesvaran; F. Salvatore; A. C. Wren; C. L. Davis; J. Allison; N. R. Barlow; R. J. Barlow; Y. M. Chia; C. L. Edgar; G. D. Lafferty; T. J. West; J. I. Yi; J. Anderson; C. Chen; A. Jawahery; D. A. Roberts; G. Simi; J. M. Tuggle; C. Dallapiccola; S. S. Hertzbach; X. Li; T. B. Moore; E. Salvati; S. Saremi; R. Cowan; D. Dujmic; P. H. Fisher; K. Koeneke; G. Sciolla; M. Spitznagel; F. Taylor; R. K. Yamamoto; M. Zhao; Y. Zheng; S. E. McLachlin; P. M. Patel; S. H. Robertson; A. Lazzaro; F. Palombo; J. M. Bauer; L. Cremaldi; V. Eschenburg; R. Godang; R. Kroeger; D. A. Sanders; D. J. Summers; H. W. Zhao; S. Brunet; D. Côté; M. Simard; P. Taras; F. B. Viaud; H. Nicholson; G. de Nardo; F. Fabozzi; L. Lista; D. Monorchio; C. Sciacca; M. A. Baak; G. Raven; H. L. Snoek; C. P. Jessop; K. J. Knoepfel; J. M. Losecco; G. Benelli; L. A. Corwin; K. Honscheid; H. Kagan; R. Kass; J. P. Morris; A. M. Rahimi; J. J. Regensburger; S. J. Sekula; Q. K. Wong; N. L. Blount; J. Brau; R. Frey; O. Igonkina; J. A. Kolb; M. Lu; R. Rahmat; N. B. Sinev; D. Strom; J. Strube; E. Torrence; N. Gagliardi; A. Gaz; M. Margoni; M. Morandin; A. Pompili; M. Posocco; M. Rotondo; F. Simonetto; R. Stroili; C. Voci; E. Ben-Haim; H. Briand; G. Calderini; J. Chauveau; P. David; L. Del Buono; Ch. de La Vaissière; O. Hamon; Ph. Leruste; J. Malclès; J. Ocariz; A. Perez; J. Prendki; L. Gladney; M. Biasini; R. Covarelli; E. Manoni

    2008-01-01

    We present measurements of the semileptonic decays B--->D0tau-nu¯tau, B--->D*0tau-nu¯tau, B¯0-->D+tau-nu¯tau, and B¯0-->D*+tau-nu¯tau, which are potentially sensitive to non-standard model amplitudes. The data sample comprises 232×106 Upsilon(4S)-->BB¯ decays collected with the BABAR detector. From a combined fit to B- and B¯0 channels, we obtain the branching fractions B(B-->Dtau-nu¯tau)=(0.86±0.24±0.11±0.06)% and B(B-->D*tau-nu¯tau)=(1.62±0.31±0.10±0.05)% (normalized for the B¯0), where the uncertainties are statistical, systematic, and

  6. Precision Measurements of Tau Lepton Decays

    SciTech Connect

    Nugent, Ian M.; /Victoria U.

    2010-03-16

    Using data collected with the BABAR detector at the SLAC PEP-II electron-positron storage ring operating at a center-of-mass energy near 10.58 GeV, the branching fractions {Beta}({tau}{sup -} {yields} {pi}{sup -}{pi}{sup -}{pi}{sup +}{nu}{sub {tau}}) = (8.83 {+-} 0.01 {+-} 0.13)%, {Beta}({tau}{sup -} {yields} K{sup -}{pi}{sup -}{pi}{sup +}{nu}{sub {tau}}) = (0.273 {+-} 0.002 {+-} 0.009)%, {Beta}({tau}{sup -} {yields} K{sup -}{pi}{sup -}K{sup +}{nu}{sub {tau}}) = (0.1346 {+-} 0.0010 {+-} 0.0036)%, and {Beta}({tau}{sup -} {yields} K{sup -}K{sup -}K{sup +}{nu}{sub {tau}}) = (1.58 {+-} 0.13 {+-} 0.12) x 10{sup -5} are measured where the uncertainties are statistical and systematic, respectively. The invariant mass distribution for the {tau}{sup -} {yields} {pi}{sup -}{pi}{sup -}{pi}{sup +}{nu}{sub {tau}} {yields} K{sup -}{pi}{sup -}{pi}{sup +}{nu}{sub {tau}}, {tau}{sup -} {yields} K{sup -}{pi}{sup -}K{sup +}{nu}{sub {tau}} and {tau}{sup -} {yields} K{sup -}K{sup -}K{sup +}{nu}{sub {tau}} decays are unfolded to correct for detector effects. A measurement of {Beta}({tau}{sup -} {yields} {phi}{pi}{sup -}{nu}{sub {tau}}) = (3.42 {+-} 0.55 {+-} 0.25) x 10{sup -5}, a measurement of {Beta}({tau}{sup -} {yields} {phi}K{sup -}{nu}{sub {tau}}) = (3.39 {+-} 0.20 {+-} 0.28) x 10{sup -5} and an upper limit on {Beta}({tau}{sup -} {yields} K{sup -}K{sup -}K{sup +}{nu}{sub {tau}}[ex.{phi}]) {le} 2.5 x 10{sup -6} {at} 905 CL are determined from a binned maximum likelihood fit of the {tau}{sup -} {yields} K{sup -}{pi}{sup -}K{sup +}{nu}{sub {tau}} and {tau}{sup -} {yields} K{sup -}K{sup -}K{sup +}{nu}{sub {tau}} K{sup +}K{sup -} invariant mass distributions. The branching ratio {Beta}({tau}{sup -} {yields} K{sup -}{nu}{sub {tau}})/{Beta}({tau}{sup -} {yields} {pi}{sup -}{nu}{sub {tau}}) is measured to be (6.531 {+-} 0.056 {+-} 0.093) x 10{sup -2} from which |V{sub us}| is determined to be 0.2255 {+-} 0.0023. The branching ratio {Beta}/({tau}{sup -} {yields} {mu}{nu}{sub {tau}}{bar {nu}}{sub {mu}})/{Beta}({tau}{sup -} {yields} e{sup -} {nu}{sub {tau}}{bar {nu}}{sub e}) = (9.796 {+-} 0.016 {+-} 0.035) x 10{sup -1} is measured enabling a precision test of the Standard Model assumption of charged current lepton universality, g{sub {mu}}/g{sub e} = 1.0036 {+-} 0.0020. The branching ratios {Beta}({tau}{sup -} {yields} K{sup -}{nu}{sub {tau}})/{Beta}({tau}{sup -} {yields} e{sup -}{nu}{sub {tau}}{bar {nu}}{sub e}) = (3.882 {+-} 0.032 {+-} 0.057) x 10{sup -2}, and {Beta}({tau}{sup -} {yields} {pi}{sup -}{nu}{sub {tau}})/{Beta}({tau}{sup -} {yields} e{nu}{sub {tau}}{bar {nu}}{sub e}) = (5.9545 {+-} 0.014 {+-} 0.061) x 10{sup -1} are measured which provide additional tests of charged current lepton universality, (g{sub {tau}}/g{sub {mu}}){sub {pi}} = 0.9856 {+-} 0.0057 and (g{sub {tau}}/g{sub {mu}}){sub K} = 0.9827 {+-} 0.0086 which can be combined to give (g{sub {tau}}/g{sub {mu}}){sub {pi}/K} = 0.9850 {+-} 0.0054. Any deviation of these measurements from the expected Standard Model values would be an indication of new physics.

  7. Tensor mesons produced in tau lepton decays

    SciTech Connect

    Lopez Castro, G.; Munoz, J. H. [Departamento de Fisica, Cinvestav, Apartado Postal 14-740, 07000 Mexico, D.F. (Mexico); Departamento de Fisica, Universidad del Tolima, Apartado Aereo 546, Ibague (Colombia) and Centro Brasileiro de Pesquisas Fisicas, Rua Xavier Sigaud 150, 22290-180, Rio de Janeiro, RJ (Brazil)

    2011-05-01

    Light tensor mesons (T=a{sub 2}, f{sub 2} and K{sub 2}*) can be produced in decays of {tau} leptons. In this paper we compute the branching ratios of {tau}{yields}T{pi}{nu} decays by assuming the dominance of intermediate virtual states to model the form factors involved in the relevant hadronic matrix elements. The exclusive f{sub 2}(1270){pi}{sup -} decay mode turns out to have the largest branching ratio, of O(10{sup -4}). Our results indicate that the contribution of tensor meson intermediate states to the three-pseudoscalar channels of {tau} decays are rather small.

  8. Tau decays into three charged leptons and two neutrinos

    E-print Network

    Ammar, Raymond G.; Baringer, Philip S.; Bean, Alice; Besson, David Zeke; Coppage, Don; Copty, N.; Davis, Robin E. P.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, Nowhan

    1996-04-01

    We search for the radiative leptonic tau decays tau --> ee(+) e(-)nu(tau)nu(e) and tau --> mu e(+)e(-)nu(tau)nu(mu) using 3.60 fb(-1) of data collected by the CLEO-II experiment at the Cornell Electron Storage Ring. We ...

  9. Speedy Higgs boson discovery in decays to tau lepton pairs : h->tau,tau

    E-print Network

    Alan J. Barr; Sky T. French; James A. Frost; Christopher G. Lester

    2011-09-12

    Discovery of the Higgs boson in any decay channel depends on the existence of event variables or cuts with sensitivity to the presence of the Higgs. We demonstrate the non-optimality of the kinematic variables which are currently expected to play the largest role in the discovery (or exclusion) of the Higgs at the LHC in the tau channel. Any LHC collaboration looking for opportunities to gain advantages over its rivals should, perhaps, consider the alternative strategy we propose.

  10. Second class current effects in tau lepton decay

    SciTech Connect

    Derrick, M.

    1987-01-01

    Experiments to see the effects of second class currents in neutrino interactions are described. Evidence from tau lepton decay is discussed, including the ''one-prong anomaly'' and direct observation of eta meson production in tau decay. (LEW)

  11. Study of Michel spectrum of tau decay

    E-print Network

    Ackerman, Nicole (Nicole L.)

    2007-01-01

    This thesis is the beginning of a larger project to use BaBar to examine weak couplings through leptonic [tau] decay. I will use the ratio of Br... and Br... and the Michel parameters [rho] and [eta]. which describe the ...

  12. A Search for the Rare Decay B0 to tau+tau- atBaBar

    SciTech Connect

    Aubert, B.; Barate, R.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Tisserand, V.; Zghiche, A.; /Annecy, LAPP; Grauges, E.; /Barcelona, IFAE; Palano, A.; Pappagallo, M.; Pompili, A.; /Bari U. /INFN, Bari; Chen, J.C.; Qi, N.D.; Rong, G.; Wang, P.; Zhu, Y.S.; /Beijing, Inst. High Energy Phys.; Eigen, G.; Ofte, I.; Stugu, B. /Bergen U. /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /Bristol U. /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, AUTHOR = Roethel, W. /UC, Irvine

    2005-11-09

    We present the results of a search for the decay B{sup 0} {yields} {tau}{sup +}{tau}{sup -} in a data sample of (232 {+-} 3) x 10{sup 6} {Upsilon}(4S) {yields} B{bar B} decays using the BABAR detector. Certain extensions of the Standard Model predict measurable levels of this otherwise rare decay. We reconstruct fully one neutral B meson and seek evidence for the signal decay in the rest of the event. We find no evidence for signal events and obtain {Beta}(B{sup 0} {yields} {tau}{sup +}{tau}{sup -}) < 3.2 x 10{sup -3} at the 90% confidence level.

  13. TauDecay: a library to simulate polarized tau decays via FeynRules and MadGraph5

    E-print Network

    Kaoru Hagiwara; Tong Li; Kentarou Mawatari; Junya Nakamura

    2014-12-15

    TauDecay is a library of helicity amplitudes to simulate polarized tau decays, constructed in the FeynRules and MadGraph5 framework. Together with the leptonic mode, the decay library includes the main hadronic modes, \\tau \\to \

  14. Measurement of the branching ratio for Ds>tau- nu¯tau decays

    Microsoft Academic Search

    G. Abbiendi; C. Ainsley; P. F. Åkesson; G. Alexander; J. Allison; G. Anagnostou; K. J. Anderson; S. Arcelli; S. Asai; D. Axen; G. Azuelos; I. Bailey; A. H. Ball; E. Barberio; R. J. Barlow; R. J. Batley; T. Behnke; K. W. Bell; G. Bella; A. Bellerive; G. Benelli; S. Bethke; O. Biebel; I. J. Bloodworth; O. Boeriu; P. Bock; J. Böhme; D. Bonacorsi; M. Boutemeur; S. Braibant; L. Brigliadori; R. M. Brown; H. J. Burckhart; J. Cammin; P. Capiluppi; R. K. Carnegie; B. Caron; A. A. Carter; J. R. Carter; C. Y. Chang; D. G. Charlton; P. E. L. Clarke; E. Clay; I. Cohen; J. Couchman; A. Csilling; M. Cuffiani; S. Dado; G. M. Dallavalle; S. Dallison; A. De Roeck; E. A. De Wolf; P. Dervan; K. Desch; B. Dienes; M Donkers; J. Dubbert; E. Duchovni; G. Duckeck; I. P. Duerdoth; P. G. Estabrooks; E. Etzion; F. Fabbri; M. Fanti; L. Feld; P. Ferrari; F. Fiedler; I. Fleck; M. Ford; A Fürtjes; D. I. Futyan; P. Gagnon; J. W. Gary; G. Gaycken; C. Geich-Gimbel; G. Giacomelli; P. Giacomelli; D. Glenzinski; J. Goldberg; C. Grandi; K. Graham; E. Gross; J. Grunhaus; M. Gruwé; P. O. Günther; A. Gupta; C. Hajdu; G. G. Hanson; K. Harder; A. Harel; M. Harin-Dirac; M. Hauschild; C. M. Hawkes; R. Hawkings; R. J. Hemingway; C. Hensel; G. Herten; R. D. Heuer; J. C. Hill; K. Hoffman; R. J. Homer; A. K. Honma; D. Horváth; K. R. Hossain; R. Howard; P. Hüntemeyer; P. Igo-Kemenes; K. Ishii; A. Jawahery; H. Jeremie; C. R. Jones; P. Jovanovic; T. R. Junk; N. Kanaya; J. Kanzaki; G. Karapetian; D. Karlen; V. Kartvelishvili; K. Kawagoe; T. Kawamoto; R G Kellogg; B. W. Kennedy; D. H. Kim; K. Klein; A. Klier; S. Kluth; T. Kobayashi; M. Kobel; T. P. Kokott; S. Komamiya; R. V. Kowalewski; T. Kämer; T. Kress; P. Krieger; J. von Krogh; D. Krop; T. Kuhl; M. Kupper; P. Kyberd; G. D. Lafferty; H. Landsman; D. Lanske; I. Lawson; J. G. Layter; A. Leins; D. Lellouch; J. Letts; L. Levinson; R. Liebisch; J. Lillich; C. Littlewood; A. W. Lloyd; S. L. Lloyd; F. K. Loebinger; G. D. Long; M. J. Losty; J Ludwig; A L MacPherson; W. Mader; S. Marcellini; T. E. Marchant; A. J. Martin; J. P. Martin; G. Martinez; T. Mashimo; P. Mättig; W. J. McDonald; J. McKenna; T. J. McMahon; R. A. McPherson; F. Meijers; P. Mendez-Lorenzo; W. Menges; F. S. Merritt; H. Mes; A. Michelini; S. Mihara; G. Mikenberg; D. J. Miller; W. Mohr; A. Montanari; T. Mori; K. Nagai; I. Nakamura; H. A. Neal; R. Nisius; S. W. O'Neale; F. G. Oakham; F. Odorici; A N Okpara; M. J. Oreglia; S. Orito; C. Pahl; G. Pásztor; J. R. Pater; G. N. Patrick; J. E. Pilcher; J. Pinfold; D. E. Plane; B. Poli; J. Polok; O. Pooth; A. Quadt; K. Rabbertz; C. Rembser; P. Renkel; H. Rick; N. Rodning; J. M. Roney; S. Rosati; K. Roscoe; A. M. Rossi; Y. Rozen; K. Runge; O. Runolfsson; D. R. Rust; K. Sachs; T. Saeki; O. Sahr; E. K. G. Sarkisyan; C. Sbarra; A. D. Schaile; O. Schaile; P. Scharff-Hansen; C. Schmitt; M Schumacher; C. Schwick; W. G. Scott; R. Seuster; T. G. Shears; B. C. Shen; C. H. Shepherd-Themistocleous; P. Sherwood; G. P. Siroli; A M Smith; G. A. Snow; R. Sobie; S. Söldner-Rembold; S. Spagnolo; F. Spano; M. Sproston; A. Stahl; K. Stephens; D. Strom; R. Ströhmer; L. Stumpf; B. Surrow; S. D. Talbot; S. Tarem; M. Tasevsky; R Teuscher; J. Thomas; M. A. Thomson; E. Torrence; S. Towers; D. Toya; T. Trefzger; I. Trigger; Z. Trócsányi; E. Tsur; M. F. Turner-Watson; I. Ueda; B. Vachon; C. F. Vollmer; P. Vannerem; M. Verzocchi; H. Voss; J. Vossebeld; D. Waller; C. P. Ward; D. R. Ward; P. M. Watkins; A. T. Watson; N. K. Watson; P. S. Wells; T. Wengler; N. Wermes; D. Wetterling; J. S. White; G. W. Wilson; J. A. Wilson; T. R. Wyatt; S. Yamashita; V. Zacek; D. Zer-Zion

    2001-01-01

    Using about 3.9 million hadronic Z decays from e+e- collisions recorded by the OPAL detector at LEP at centre-of-mass energies sqrt(s)~MZ, the branching ratio for the decay D-s-->tau- nu¯tau has been measured to be BR(D-s-->tau- nu¯tau)=(7.0+\\/-2.1(stat)+\\/-2.0(syst))%. This result can be used to derive the decay constant of the D-s meson: fDs=(286+\\/-44(stat)+\\/-41(syst))MeV.

  15. Unraveling duality violations in hadronic tau decays

    SciTech Connect

    Cata, Oscar; Cata, Oscar; Golterman, Maarten; Peris, Santiago

    2008-03-03

    There are some indications from recent determinations of the strong coupling constant alpha_s and the gluon condensate that the Operator Product Expansion may not be accurate enough to describe non-perturbative effects in hadronic tau decays. This breakdown of the Operator Product Expansion is usually referred to as being due to"Duality Violations." With the help of a physically motivated model, we investigate these duality violations. Based on this model, we argue how they may introduce a non-negligible systematic error in the current analysis, which employs finite-energy sum rules with pinched weights. In particular, this systematic effect might affect the precision determination of alpha_s from tau decays. With a view to a possible future application to real data, we present an alternative method for determining the OPE coefficients that might help estimating, and possibly even reducing, this systematic error.

  16. Searches for Lepton Flavor Violation in the Decays tau+- ---> e+- gamma and tau+- ---> mu+- gamma

    SciTech Connect

    Aubert, Bernard; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Battaglia, M.; Brown, David Nathan; Hooberman, B.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS; /more authors.; ,

    2010-06-11

    Searches for lepton-flavor-violating decays of a {tau} lepton to a lighter mass lepton and a photon have been performed with the entire dataset of (963 {+-} 7) x 10{sup 6} {tau} decays collected by the BABAR detector near the {Upsilon}(4S), {Upsilon}(3S) and {Upsilon}(2S) resonances. The searches yield no evidence of signals and they set upper limits on the branching fractions of {Beta}({tau}{sup {+-}} {yields} e{sup {+-}}{gamma}) < 3.3 x 10{sup -8} and {Beta}({tau}{sup {+-}} {yields} {mu}{sup {+-}}{gamma}) < 4.4 x 10{sup -8} at 90% confidence level.

  17. Study of tau decays to six pions and a neutrino

    E-print Network

    Ammar, Raymond G.; Bean, Alice; Besson, David Zeke; Zhao, X.

    2001-05-01

    The tau decays to six-pion final states have been studied with the CLEO detector at the Cornell Electron Storage Ring. The measured branching fractions are B(tau (-) --> 2 pi (-)pi (-)3 pi (0)nu (tau)) = (2.2 +/- 0.3 +/- 0.4) X 10(-4) and B...

  18. Study of the decay tau(-)->2 pi(-)pi(+)3 pi(0)nu(tau)

    E-print Network

    Ammar, Raymond G.; Baringer, Philip S.; Bean, Alice; Besson, David Zeke; Coppage, Don; Darling, C.; Davis, Robin E. P.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, Nowhan

    1997-11-01

    The decay tau(-) --> 2 pi(-)pi(+)3 pi(0) nu(tau) has been studied with the CLEO II detector at the Cornell Electron Storage Ring. The branching fraction is measured to be (2.85 +/- 0.56 +/- 0.51) x 10(-4). The result is ...

  19. Limit on tau decay to 7-charged tracks

    SciTech Connect

    Abachi, S.; Akerlof, C.; Baringer, P.; Blockus, D.; Brabson, B.; Brom, J.M.; Bylsma, B.G.; Chapman, J.; Cork, B.; De Bonte, R.

    1986-01-01

    Using the complete data sample of 300 pb/sup -1/ from e/sup +/e/sup -/ collisions at 29 GeV, the HRS collaboration has searched for tau decay to 7 charged particles and any number of neutrals. No events were found. The corresponding upper limit to the branching ratio is B(tau ..-->.. 7..pi../sup + -/ + n..gamma.. + nu/sub tau/) < 3.8 x 10/sup -4/ at 90% confidence level. Using the final HRS data sample we also report updated branching ratios for tau ..-->.. 5..pi../sup + -/ + nu/sub tau/ and tau ..-->.. 5..pi../sup + -/ + ..pi../sup 0/ + nu/sub tau/.

  20. Observation of tau-lepton decay to five charged particles

    SciTech Connect

    Beltrami, I.; Bylsma, B.G.; DeBonte, R.; Gan, K.K.; Koltick, D.; Loeffler, F.J.; Low, E.H.; McIlwain, R.L.; Miller, D.H.; Ng, C.R.; Ong, P.P.; Rangan, L.K.; Shibata, E.I.; Wilson, R.J.; Derrick, M.; Fernandez, E.; Fries, R.; Hyman, L.; Kooijman, P.; Loos, J.S.; Musgrave, B.; Price, L.E.; Schlereth, J.; Sugano, K.; Weiss, J.M.; Wood, D.E.; Baranko, G.; Baringer, P.; Blockus, D.; Brabson, B.; Forden, G.E.; Gray, S.W.; Jung, C.; Neal, H.; Ogren, H.; Rust, D.R.; Valdata-Nappi, M.; Akerlof, C.; Bonvicini, G.; Chapman, J.; Errede, D.; Harnew, N.; Kesten, P.; Kooijman, S.; Meyer, D.I.; Nitz, D.; Rubin, D.; Seidl, A.A.; Thun, R.; Trinko, T.; Willutzky, W.; Cork, B.; Keller, L.; Va'Vra, J.

    1985-04-22

    The production of tau-lepton pairs in e/sup +/e/sup -/ collisions at 29 GeV has been used to study the inclusive tau decay into five charged particles. Ten events are observed in the high-resolution spectrometer giving a branching ratio of B(tau..-->..5..pi../sup + -/+n..gamma..+..nu../sub tau/) = (1.3 +- 0 .4) x 10/sup -3/. Five of the events contain photons which are consistent with coming from a single ..pi../sup 0/. With this interpretation we measure B(tau..-->..5..pi.. +- +..nu../sub tau/), B(tau..-->..5..pi../sup + -/+..pi../sup 0/+..nu../sub tau/) = (6.7 +- 3.0) x 10/sup -4/. The branching-ratio upper limit for the decay mode tau..-->..K/sup 0/+3..pi../sup + -/n..gamma..+..nu../sub tau/ is found, at 90% confidence level, to be 2.7 x 10/sup -3/.

  1. Multiple-neutral-meson decays of the /tau/ lepton and electromagnetic calorimeter requirements at Tau-Charm Factory

    SciTech Connect

    Gan, K.K.

    1989-08-01

    This is a study of the physics sensitivity to the multiple-neutral-meson decays of the /tau/ lepton at the Tau-Charm Factory. The sensitivity is compared for a moderate and an ultimate electromagnetic calorimeter. With the high luminosity of the Tau- Charm Factory, a very large sample of the decays /tau//sup /minus// /yields/ /pi//sup /minus//2/pi//sup 0//nu//sub /tau// and /tau//sup /minus// /yields/ /pi//sup /minus//3/pi//sup 0//nu//sub /tau// can be collected with both detectors. However, with the ultimate detector, 2/pi//sup 0/ and 3/pi//sup 0/ can be unambiguously reconstructed with very little background. For the suppressed decay /tau//sup /minus// /yields/ /pi//sup /minus///eta//pi//sup 0//nu//sub /tau//, only the ultimate detector has the sensitivity. The ultimate detector is also sensitive to the more suppressed decay /tau//sup /minus// /yields/ K/sup /minus///eta//nu//sub /tau// and the moderate detector may have the sensitivity if the hadronic background is not significantly larger than that predicted by Lund. In the case of the highly suppressed second-class-current decay /tau//sup /minus// /yields/ /pi//sup /minus///eta//nu//sub /tau//, only the ultimate detector has sensitivity. The sensitivity can be greatly enhanced with a small-angle photon veto. 16 refs., 9 figs., 2 tabs.

  2. First measurement of the branching fraction of the decay psi(2S)-->tau+tau-

    Microsoft Academic Search

    J. Z. Bai; Y. Ban; J. G. Bian; I. Blum; A. D. Chen; H. F. Chen; H. S. Chen; J. Chen; X. D. Chen; Y. Chen; B. S. Cheng; S. P. Chi; Y. P. Chu; J. B. Choi; X. Z. Cui; Y. S. Dai; L. Y. Dong; Z. Z. Du; W. Dunwoodie; H. Y. Fu; L. P. Fu; C. S. Gao; P. Gratton; S. D. Gu; Y. F. Gu; Y. N. Guo; Z. J. Guo; S. W. Han; Y. Han; F. A. Harris; J. He; K. L. He; M. He; X. He; T. Hong; Y. K. Heng; D. G. Hitlin; G. Y. Hu; H. M. Hu; Q. H. Hu; T. Hu; G. S. Huang; X. P. Huang; Y. Z. Huang; J. M. Izen; X. B. Ji; C. H. Jiang; Y. Jin; B. D. Jones; J. S. Kang; Z. J. Ke; M. H. Kelsey; B. K. Kim; H. J. Kim; S. K. Kim; T. Y. Kim; D. Kong; Y. F. Lai; A. Lankford; D. Li; H. B. Li; H. H. Li; J. Li; P. Q. Li; Q. J. Li; R. Y. Li; W. Li; X. N. Li; X. Q. Li; B. Liu; F. Liu; Feng. Liu; H. M. Liu; J. Liu; T. R. Liu; R. G. Liu; Y. Liu; Z. X. Liu; X. C. Lou; B. Lowery; G. R. Lu; F. Lu; J. G. Lu; Z. J. Lu; X. L. Luo; E. C. Ma; J. M. Ma; R. Malchow; H. S. Mao; Z. P. Mao; X. C. Meng; X. H. Mo; J. Nie; Z. D. Nie; S. L. Olsen; J. Oyang; D. Paluselli; L. J. Pan; J. Panetta; F. Porter; N. D. Qi; X. R. Qi; C. D. Qian; J. F. Qiu; Y. K. Que; G. Rong; M. Schernau; Y. Y. Shao; B. W. Shen; D. L. Shen; H. Shen; X. Y. Shen; H. Y. Sheng; F. Shi; H. Z. Shi; X. F. Song; J. Standifird; J. Y. Suh; H. S. Sun; L. F. Sun; Y. Z. Sun; S. Q. Tang; W. Toki; G. L. Tong; G. S. Varner; J. Wang; L. Wang; Meng Wang; P. Wang; S. M. Wang; Y. Y. Wang; Z. Y. Wang; M. Weaver; C. L. Wei; J. M. Wu; N. Wu; D. M. Xi; X. M. Xia; X. X. Xie; G. F. Xu; Y. Xu; S. T. Xue; W. B. Yan; W. G. Yan; C. M. Yang; C. Y. Yang; G. A. Yang; H. X. Yang; X. F. Yang; M. H. Ye; S. W. Ye; Y. X. Ye; C. S. Yu; C. X. Yu; G. W. Yu; Y. Yuan; B. Y. Zhang; C. Zhang; D. H. Zhang; H. L. Zhang; H. Y. Zhang; J. Zhang; L. Zhang; P. Zhang; Q. J. Zhang; S. Q. Zhang; X. Y. Zhang; Y. Y. Zhang; Z. P. Zhang; D. X. Zhao; H. W. Zhao; Jiawei Zhao; M. Zhao; P. P. Zhao; W. R. Zhao; Y. B. Zhao; Z. G. Zhao; J. P. Zheng; L. S. Zheng; Z. P. Zheng; B. Q. Zhou; G. M. Zhou; L. Zhou; K. J. Zhu; Q. M. Zhu; Y. C. Zhu; Y. S. Zhu; Z. A. Zhu; B. A. Zhuang; B. S. Zou

    2002-01-01

    The branching fraction of the psi(2S) decay into tau+tau- has been measured for the first time using the BES detector at the Beijing Electron-Positron Collider. The result is Btautau=(2.71+\\/-0.43+\\/-0.55)×10-3, where the first error is statistical and the second is systematic. This value, along with those for the branching fractions into e+e- and mu+mu- of this resonance, satisfy well the relation

  3. Resonance chiral Lagrangian currents and tau decay Monte Carlo

    E-print Network

    O. Shekhovtsova; T. Przedzinski; P. Roig; Z. Was

    2013-01-16

    Measurements of tau lepton, because of its long lifetime, large mass and parity sensitive couplings lead to broad physics interest. From the perspective of high-energy experiments such as at LHC, knowledge of tau lepton properties offers an important ingredient of new physics signatures. From the perspective of lower energies, tau lepton decays constitute an excellent laboratory for hadronic interactions. At present,hundreds of millions of tau decays have been amassed by both Belle and BaBar experiments. It is of utmost importance to represent such data in a form as useful for general applications as possible. In the present paper we describe the set of form factors for hadronic tau decays based on Resonance Chiral Theory. The technical implementation of the form factors in FORTRAN code is also explained. It is shown how it can be installed into TAUOLA Monte Carlo program. Then it is rather easy to implement into software environments of not only Belle and BaBar collaborations but also for FORTRAN and C++ applications of LHC. Description of the current for each tau decay mode is complemented with technical numerical tests. The set is ready for fits, parameters to be used in fits are explained. Arrangements to work with the experimental data not requiring unfolding are prepared. Hadronic currents, ready for confrontation with the tau decay data, but not yet ready for the general use, cover more than 88% of hadronic tau decay width.

  4. The decay tau. -->. rho nu (and rho. -->. pi. eta nu. )

    SciTech Connect

    Stockhausen, W.

    1987-04-01

    Motivated by the question of missing exclusive branching fractions in tau decays, mostly suspected to be in one prong decays with neutrals, we have studied the decay tau ..-->.. rho nu in tau pair production by e/sup +/e/sup -/ annihilation at ..sqrt..s = 3.77 GeV. The branching fraction is measured to be B(tau ..-->.. rho nu) = (23.0 +- 1.3 +- 1.7)% consistent with known measurements and not offering a solution to the branching ratio question. No eta signal in the ..gamma gamma.. mass spectrum pointing to a decay tau ..-->.. eta ..pi.. nu is obvious. An upper limit on this branching fraction is given.

  5. Charged kaon production in tau decays at LEP

    Microsoft Academic Search

    P. Abreu; W. Adam; T. Adye; E. Agasi; I. Ajinenko; Roy Aleksan; G. D. Alekseev; P. P. Allport; S. Almehed; F. M. L. Almeida; S. J. Alvsvaag; Ugo Amaldi; A. Andreazza; P. Antilogus; W.-D. Apel; R. J. Apsimon; Y. Arnoud; B. Åsman; J.-E. Augustin; A. Augustinus; Paul Baillon; P. Bambade; F. Barao; R. Barate; Guido Barbiellini; Dimitri Yuri Bardin; G. J. Barker; A. Baroncelli; O. Barring; J. A. Barrio; Walter Bartl; M. J. Bates; Marco Battaglia; M. Baubillier; J. Baudot; K.-H. Becks; M. Begalli; P. Beilliere; P. Beltran; A. C. Benvenuti; M. Berggren; D. Bertrand; F. Bianchi; M. Bigi; M. S. Bilenky; P. Billoir; J. Bjarne; D. Bloch; J. Blocki; S. Blyth; V. Bocci; P. N. Bogolubov; T. Bolognese; M. Bonesini; W. Bonivento; P. S. L. Booth; G. Borisov; C. Bosio; B. Bostjancic; S. Bosworth; O. Botner; B. Bouquet; C. Bourdarios; T. J. V. Bowcock; M. Bozzo; S. Braibant; P. Branchini; K. D. Brand; R. A. Brenner; H. Briand; C. Bricman; L. Brillault; R. C. A. Brown; P. Bruckman; J.-M. Brunet; L. Bugge; T. Buran; A. Buys; J. A. M. A. Buytaert; M. Caccia; M. Calvi; A. J. Camacho Rozas; R. Campion; T. Camporesi; V. Canale; K. Cankocak; F Carena; P. Carrilho; L. Carroll; R. Cases; C. Caso; M. V. Castillo Gimenez; A. Cattai; F. R. Cavallo; L. Cerrito; V. Chabaud; A. Chan; Ph. Charpentier; J. Chauveau; P. Checchia; G. A. Chelkov; P V Chliapnikov; V. Chorowicz; J. T. M. Chrin; V. Cindro; P. Collins; J. L. Contreras; R. Contri; E. Cortina; G. Cosme; F. Couchot; H. B. Crawley; D J Crennell; G. Crosetti; J. Cuevas Maestro; S. Czellar; Erik Dahl-Jensen; J. Dahm; B. Dalmagne; M. Dam; G. Damgaard; Evelyne Daubie; A. Daum; P. D. Dauncey; Martyn Davenport; J. Davies; W. da Silva; C. Defoix; P A Delpierre; N. Demaria; A. de Angelis; H. de Boeck; Wim de Boer; S. de Brabandere; C. de Clercq; M. D. M. de Fez Laso; C. de La Vaissiere; B. de Lotto; A. de Min; L S De Paula; C. de Saint-Jean; H. Dijkstra; L. di Ciaccio; F. Djama; J. Dolbeau; M. Donszelmann; K. Doroba; M. Dracos; J. Drees; M. Dris; Y. Dufour; F. Dupont; D. Edsall; R. Ehret; T. Ekelof; G. Ekspong; M. Elsing; J.-P. Engel; N. Ershaidat; M. Espirito Santo; D. Fassouliotis; M. Feindt; A. Fenyuk; A Filippas-Tassos; T. A. Filippas; A. Firestone; H. Foeth; E. Fokitis; F. Fontanelli; F. Formenti; J.-L. Fousset; S. Francon; B. Franek; P. Frenkiel; D. C. Fries; A. G. Frodesen; R. Fruhwirth; F. Fulda-Quenzer; H. Furstenau; J. Fuster; D. Gamba; M. Gandelman; C. Garcia; J. Garcia; C. Gaspar; U. Gasparini; Ph. Gavillet; E. N. Gazis; D. Gele; J.-P. Gerber; L. Gerdyukov; P. Giacomelli; D. Gillespie; R. Gokieli; B. Golob; V. M. Golovatyuk; J. J. Gomez Y Cadenas; G. Gopal; L. Gorn; M. Gorski; V. Gracco; F. Grard; E. Graziani; G. Grosdidier; P. Gunnarsson; J. Guy; U. Haedinger; F. Hahn; M. Hahn; S Haider; Z. Hajduk; A. Hakansson; A. Hallgren; K. Hamacher; W. Hao; F. J. Harris; V. Hedberg; R P Henriques; J. J. Hernandez; J. A. Hernando; P. Herquet; H. Herr; T. L. Hessing; E. Higon; Hans Jürgen Hilke; T. S. Hill; S.-O. Holmgren; P. J. Holt; D J Holthuizen; P. F. Honore; M A Houlden; Josef Hrubec; K. Huet; K. Hultqvist; P. Ioannou; P.-S. Iversen; J. N. Jackson; R. Jacobsson; P. Jalocha; G. Jarlskog; P. Jarry; B. Jean-Marie; E. K. Johansson; M. Jonker; L B Jönsson; P. Juillot; M. Kaiser; George Ernest Kalmus; F. Kapusta; M. Karlsson; E. Karvelas; S. Katsanevas; E. C. Katsoufis; R. Keranen; B. A. Khomenko; N N Khovanskii; B J King; N. J. Kjaer; H. Klein; A. Klovning; P M Kluit; A. Koch-Mehrin; J. H. Koehne; B. Koene; P. Kokkinias; M. Koratzinos; A. V. Korytov; V. Kostioukhine; C. Kourkoumelis; O. Kouznetsov; P. H. Kramer; Manfred Krammer; C. Kreuter; J. Krolikowski; I J Kronkvist; W. Krupinski; W. Kucewicz; K. Kulka; K L Kurvinen; C. Lacasta; C. Lambropoulos; J. W. Lamsa; L. Lanceri; P. Langefeld; V. Lapin; I. Last; J.-P. Laugier; R. Lauhakangas; F. Ledroit; R. Leitner; Y. Lemoigne; J. Lemonne; Georg Lenzen; V. Lepeltier; T. Lesiak; J. M. Levy; E H Lieb; D. Liko; R. Lindner; A. Lipniacka; I. Lippi; B. Loerstad; M. Lokajicek; J. G. Loken; A. Lopez-Fernandez; M. A. Lopez Aguera; M E Los; D. Loukas; J Lozano-Bahilo; P. Lutz; L. Lyons; G. Maehlum; J. Maillard; A. Maio; A. Maltezos; F. Mandl; J. Marco; B. Marechal; M. Margoni; J.-C. Marin; C. Mariotti; A. Markou; T. Maron; S. Marti; C. Martinez-Rivero; F. Martinez-Vidal; F. Matorras; C. Matteuzzi; Giorgio Matthiae; M. Mazzucato; M. Mc Cubbin; R. Mc Kay; R. Mc Nulty; J. Medbo; C. Meroni; W. T. Meyer; M. Michelotto; E. Migliore; I. Mikulec; L. Mirabito; Winfried A Mitaroff; G. V. Mitselmakher; U. Mjoernmark; T. Moa; R. Moeller; K. Moenig; M. R. Monge; P. Morettini; H. Mueller; W. J. Murray; B. Muryn; Gerald Myatt; F. Naraghi; Francesco Luigi Navarria; P. Negri; S. Nemecek; W. Neumann; N. Neumeister; R. Nicolaidou; B. S. Nielsen; P E S Nilsen; A. Nomerotski; M. Novak; V. Obraztsov

    1994-01-01

    Kaon production in one prong tau decays has been studied using data collected with the DELPHI detector at the LEP collider. Charged kaons were identified over a large momentum range by the DELPHI barrel Ring Imaging Cherenkov detector. The following branching ratios have been determined: BR(tau-->Knutau)=(0.85+\\/-0.18)%, BR(tau-->Knutau>=0 neutrals)=(1.54+\\/-0.24)%, BR(tau-->Knutau>=1 neutrals)=(0.69+\\/-0.25)%. The result for the exclusive branching ratio is consistent with

  6. First observation of the decay tau-->varphiKnu

    Microsoft Academic Search

    K. Inami; K. Abe; I. Adachi; H. Aihara; D. Anipko; K. Arinstein; V. Aulchenko; T. Aushev; S. Bahinipati; A. M. Bakich; E. Barberio; M. Barbero; I. Bedny; I. Bizjak; A. Bondar; A. Bozek; M. Bracko; T. E. Browder; A. Chen; K.-F. Chen; W. T. Chen; R. Chistov; Y. Choi; J. Dalseno; M. Danilov; A. Drutskoy; S. Eidelman; D. Epifanov; S. Fratina; N. Gabyshev; T. Gershon; G. Gokhroo; H. Ha; J. Haba; K. Hara; K. Hayasaka; H. Hayashii; M. Hazumi; D. Heffernan; T. Hokuue; Y. Hoshi; S. Hou; W.-S. Hou; Y. B. Hsiung; T. Iijima; A. Ishikawa; R. Itoh; Y. Iwasaki; J. H. Kang; P. Kapusta; S. U. Kataoka; H. Kawai; T. Kawasaki; H. R. Khan; H. Kichimi; Y. J. Kim; S. Korpar; P. Krizan; P. Krokovny; R. Kulasiri; R. Kumar; A. Kuzmin; Y.-J. Kwon; G. Leder; T. Lesiak; S.-W. Lin; D. Liventsev; G. Majumder; F. Mandl; T. Matsumoto; A. Matyja; S. McOnie; W. Mitaroff; H. Miyake; H. Miyata; Y. Miyazaki; R. Mizuk; J. Mueller; Y. Nagasaka; I. Nakamura; E. Nakano; M. Nakao; S. Nishida; O. Nitoh; S. Ogawa; T. Ohshima; S. Okuno; Y. Onuki; H. Ozaki; H. Palka; C. W. Park; L. S. Peak; L. E. Piilonen; A. Poluektov; Y. Sakai; T. Schietinger; O. Schneider; A. J. Schwartz; R. Seidl; K. Senyo; M. E. Sevior; H. Shibuya; B. Shwartz; V. Sidorov; J. B. Singh; A. Somov; N. Soni; S. Stanic; M. Staric; H. Stoeck; S. Y. Suzuki; O. Tajima; N. Tamura; M. Tanaka; G. N. Taylor; Y. Teramoto; X. C. Tian; T. Tsukamoto; S. Uehara; K. Ueno; T. Uglov; S. Uno; P. Urquijo; Y. Usov; G. Varner; S. Villa; E. Won; C.-H. Wu; B. D. Yabsley; A. Yamaguchi; Y. Yamashita; L. M. Zhang; V. Zhilich; A. Zupanc

    2006-01-01

    We present the first observation of tau lepton decays to hadronic final states with a varphi-meson. This analysis is based on 401 fb-1 of data accumulated at the Belle experiment. The branching fraction obtained is B(tau-->varphiKnu)=(4.05±0.25±0.26)×10.

  7. First observation of the decay tau(-)-> K*(-)eta nu(tau)

    E-print Network

    Ammar, Raymond G.; Baringer, Philip S.; Bean, Alice; Besson, David Zeke; Coppage, Don; Darling, C.; Davis, Robin E. P.; Kotov, S.; Kravchenko, I.; Kwak, Nowhan; Zhou, L.

    1999-01-01

    gamma. The measured branching fraction is B(tau(-) --> K- pi(0)eta nu(tau)) = (2.9 +/- 0.8 +/- 0.3) x 10(-4). We also measure the inclusive branching fractions without requiring the K* resonance, B(tau(-) --> K(S)pi(-) eta nu(tau)) = (1.10 +/- 0.35 +/- 0...

  8. Study of tau Decays to Six Pions and a Neutrino

    Microsoft Academic Search

    A. Anastassov; J. E. Duboscq; E. Eckhart; K. K. Gan; C. Gwon; T. Hart; K. Honscheid; D. Hufnagel; H. Kagan; R. Kass; T. K. Pedlar; H. Schwarthoff; J. B. Thayer; E. von Toerne; M. M. Zoeller; S. J. Richichi; H. Severini; P. Skubic; A. Undrus; S. Chen; J. Fast; J. W. Hinson; J. Lee; D. H. Miller; E. I. Shibata; I. P. Shipsey; V. Pavlunin; D. Cronin-Hennessy; A. L. Lyon; E. H. Thorndike; C. P. Jessop; V. Savinov; T. E. Coan; V. Fadeyev; Y. Maravin; I. Narsky; R. Stroynowski; J. Ye; T. Wlodek; M. Artuso; R. Ayad; C. Boulahouache; K. Bukin; E. Dambasuren; S. Karamov; G. Majumder; G. C. Moneti; S. Schuh; T. Skwarnicki; S. Stone; G. Viehhauser; J. C. Wang; A. Wolf; J. Wu; S. Kopp; A. H. Mahmood; S. E. Csorna; I. Danko; K. W. McLean; Z. Xu; R. Godang; G. Bonvicini; D. Cinabro; M. Dubrovin; S. McGee; G. J. Zhou; E. Lipeles; S. P. Pappas; M. Schmidtler; A. Shapiro; W. M. Sun; A. J. Weinstein; F. Würthwein; D. E. Jaffe; G. Masek; H. P. Paar; E. M. Potter; S. Prell; D. M. Asner; A. Eppich; T. S. Hill; R. J. Morrison; R. A. Briere; G. P. Chen; W. T. Ford; A. Gritsan; J. Roy; J. G. Smith; J. P. Alexander; R. Baker; C. Bebek; B. E. Berger; K. Berkelman; F. Blanc; V. Boisvert; D. G. Cassel; P. S. Drell; K. M. Ecklund; R. Ehrlich; A. D. Foland; P. Gaidarev; R. S. Galik; L. Gibbons; B. Gittelman; S. W. Gray; D. L. Hartill; B. K. Heltsley; P. I. Hopman; L. Hsu; C. D. Jones; D. L. Kreinick; M. Lohner; A. Magerkurth; T. O. Meyer; N. B. Mistry; E. Nordberg; J. R. Patterson; D. Peterson; D. Riley; A. Romano; J. G. Thayer; D. Urner; B. Valant-Spaight; A. Warburton; P. Avery; C. Prescott; A. I. Rubiera; H. Stoeck; J. Yelton; G. Brandenburg; A. Ershov; Y. S. Gao; D. Y.-J. Kim; R. Wilson; T. Bergfeld; B. I. Eisenstein; J. Ernst; G. E. Gladding; G. D. Gollin; R. M. Hans; E. Johnson; I. Karliner; M. A. Marsh; M. Palmer; C. Plager; C. Sedlack; M. Selen; J. J. Thaler; J. Williams; K. W. Edwards; R. Janicek; P. M. Patel; A. J. Sadoff; R. Ammar; A. Bean; D. Besson; X. Zhao; S. Anderson; V. V. Frolov; Y. Kubota; S. J. Lee; R. Mahapatra; J. J. O'Neill; R. Poling; T. Riehle; A. Smith; C. J. Stepaniak; J. Urheim; S. Ahmed; M. S. Alam; S. B. Athar; L. Jian; L. Ling; M. Saleem; S. Timm; F. Wappler

    2001-01-01

    The tau decays to six-pion final states have been studied with the CLEO detector at the Cornell Electron Storage Ring. The measured branching fractions are B\\\\(tau--->2pi- pi+3pi0nutau\\\\) = \\\\(2.2+\\/-0.3+\\/-0.4\\\\)×10-4 and B\\\\(tau--->3pi- 2pi+pi0nutau\\\\) = \\\\(1.7+\\/-0.2+\\/-0.2\\\\)×10-4. A search for substructure in these decays shows that they are saturated by intermediate states with eta or omega mesons. We present the first observation of

  9. Search for tau- ---> 4pi- 3pi+ (pi0) nu/tau Decays

    SciTech Connect

    Ter-Antonian, R.; Kass, R.; Allmendinger, T.; /Ohio State U.; Hast, C.; /SLAC

    2005-06-21

    A search for the decay of the {tau} lepton to seven charged pions and at most one {pi}{sup 0} was performed using the BABAR detector at the PEP-II e{sup +}e{sup -} collider. The analysis uses data recorded on and near the {Upsilon}(4S) resonance between 1999 and 2003, a total of 124.3 fb{sup -1}. They observe 7 events with an expected background of 11.9 {+-} 2.2 events and calculate a preliminary upper limit of BR({tau}{sup -} {yields} 4{pi}{sup -} 3{pi}{sup +}({pi}{sup 0}){nu}{sub {tau}}) < 2.7 x 10{sup -7} at 90% CL. This is a significant improvement over the previous limit established by the CLEO Collaboration.

  10. Measurement of the branching fraction of B^+ -> tau^+ nu_tau decays with the semileptonic tagging method

    E-print Network

    Belle Collaboration; B. Kronenbitter; M. Heck; P. Goldenzweig; T. Kuhr; A. Abdesselam; I. Adachi; H. Aihara; S. Al Said; K. Arinstein; D. M. Asner; T. Aushev; R. Ayad; T. Aziz; A. M. Bakich; V. Bansal; E. Barberio; V. Bhardwaj; A. Bondar; G. Bonvicini; A. Bozek; M. Bra?ko; T. E. Browder; D. ?ervenkov; V. Chekelian; A. Chen; B. G. Cheon; K. Chilikin; R. Chistov; K. Cho; V. Chobanova; Y. Choi; D. Cinabro; J. Dalseno; M. Danilov; J. Dingfelder; Z. Doležal; Z. Drásal; A. Drutskoy; D. Dutta; S. Eidelman; D. Epifanov; H. Farhat; J. E. Fast; T. Ferber; O. Frost; B. G. Fulsom; V. Gaur; N. Gabyshev; A. Garmash; D. Getzkow; R. Gillard; R. Glattauer; B. Golob; J. Grygier; K. Hayasaka; H. Hayashii; X. H. He; M. Heider; A. Heller; T. Horiguchi; M. Huschle; T. Iijima; K. Inami; A. Ishikawa; R. Itoh; Y. Iwasaki; I. Jaegle; K. K. Joo; T. Julius; K. H. Kang; E. Kato; D. Y. Kim; H. J. Kim; J. B. Kim; J. H. Kim; K. T. Kim; M. J. Kim; S. H. Kim; Y. J. Kim; K. Kinoshita; B. R. Ko; P. Kodyš; P. Križan; P. Krokovny; A. Kuzmin; Y. -J. Kwon; J. S. Lange; D. H. Lee; I. S. Lee; P. Lewis; L. Li Gioi; J. Libby; D. Liventsev; P. Lukin; D. Matvienko; H. Miyata; R. Mizuk; G. B. Mohanty; S. Mohanty; A. Moll; H. K. Moon; R. Mussa; E. Nakano; M. Nakao; T. Nanut; Z. Natkaniec; M. Nayak; N. K. Nisar; S. Nishida; S. Okuno; S. L. Olsen; W. Ostrowicz; C. Oswald; P. Pakhlov; G. Pakhlova; H. Park; T. K. Pedlar; L. Pesántez; R. Pestotnik; M. Petri?; L. E. Piilonen; C. Pulvermacher; E. Ribežl; M. Ritter; A. Rostomyan; S. Ryu; Y. Sakai; L. Santelj; T. Sanuki; Y. Sato; V. Savinov; O. Schneider; G. Schnell; M. Schram; C. Schwanda; K. Senyo; O. Seon; M. E. Sevior; V. Shebalin; T. -A. Shibata; J. -G. Shiu; B. Shwartz; A. Sibidanov; F. Simon; Y. -S. Sohn; A. Sokolov; E. Solovieva; S. Stani?; M. Stari?; M. Steder; T. Sumiyoshi; U. Tamponi; Y. Teramoto; K. Trabelsi; M. Uchida; S. Uehara; T. Uglov; Y. Unno; S. Uno; P. Urquijo; Y. Usov; C. Van Hulse; P. Vanhoefer; G. Varner; A. Vinokurova; A. Vossen; M. N. Wagner; C. H. Wang; M. -Z. Wang; P. Wang; M. Watanabe; Y. Watanabe; K. M. Williams; E. Won; H. Yamamoto; S. Yashchenko; Y. Yook; Z. P. Zhang; V. Zhilich; V. Zhulanov; M. Ziegler; A. Zupanc

    2015-03-18

    We report a measurement of the branching fraction of B^+ -> tau^+ nu_tau decays using a data sample of 772 x 10^6 BBbar pairs, collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^+e^- collider. We reconstruct the accompanying B meson in a semileptonic decay and detect the recoiling B candidate in the decay channel B^+ -> tau^+ nu_tau. We obtain a branching fraction of BR(B^+ -> tau^+ nu_tau) = [1.25 +- 0.28 (stat.) +- 0.27 (syst.)] x 10^-4. This result is in good agreement with previous measurements and the expectation from the calculation based on the Standard Model.

  11. Measurement of the branching fraction of B^+ -> tau^+ nu_tau decays with the semileptonic tagging method

    E-print Network

    Kronenbitter, B; Goldenzweig, P; Kuhr, T; Abdesselam, A; Adachi, I; Aihara, H; Said, S Al; Arinstein, K; Asner, D M; Aushev, T; Ayad, R; Aziz, T; Bakich, A M; Bansal, V; Barberio, E; Bhardwaj, V; Bondar, A; Bonvicini, G; Bozek, A; Bra?ko, M; Browder, T E; ?ervenkov, D; Chekelian, V; Chen, A; Cheon, B G; Chilikin, K; Chistov, R; Cho, K; Chobanova, V; Choi, Y; Cinabro, D; Dalseno, J; Danilov, M; Dingfelder, J; Doležal, Z; Drásal, Z; Drutskoy, A; Dutta, D; Eidelman, S; Epifanov, D; Farhat, H; Fast, J E; Ferber, T; Frost, O; Fulsom, B G; Gaur, V; Gabyshev, N; Garmash, A; Getzkow, D; Gillard, R; Glattauer, R; Golob, B; Grygier, J; Hayasaka, K; Hayashii, H; He, X H; Heider, M; Heller, A; Horiguchi, T; Huschle, M; Iijima, T; Inami, K; Ishikawa, A; Itoh, R; Iwasaki, Y; Jaegle, I; Joo, K K; Julius, T; Kang, K H; Kato, E; Kim, D Y; Kim, H J; Kim, J B; Kim, J H; Kim, K T; Kim, M J; Kim, S H; Kim, Y J; Kinoshita, K; Ko, B R; Kodyš, P; Križan, P; Krokovny, P; Kuzmin, A; Kwon, Y -J; Lange, J S; Lee, D H; Lee, I S; Lewis, P; Gioi, L Li; Libby, J; Liventsev, D; Lukin, P; Matvienko, D; Miyata, H; Mizuk, R; Mohanty, G B; Mohanty, S; Moll, A; Moon, H K; Mussa, R; Nakano, E; Nakao, M; Nanut, T; Natkaniec, Z; Nayak, M; Nisar, N K; Nishida, S; Okuno, S; Olsen, S L; Ostrowicz, W; Oswald, C; Pakhlov, P; Pakhlova, G; Park, H; Pedlar, T K; Pesántez, L; Pestotnik, R; Petri?, M; Piilonen, L E; Pulvermacher, C; Ribežl, E; Ritter, M; Rostomyan, A; Ryu, S; Sakai, Y; Santelj, L; Sanuki, T; Sato, Y; Savinov, V; Schneider, O; Schnell, G; Schram, M; Schwanda, C; Senyo, K; Seon, O; Sevior, M E; Shebalin, V; Shibata, T -A; Shiu, J -G; Shwartz, B; Sibidanov, A; Simon, F; Sohn, Y -S; Sokolov, A; Solovieva, E; Stani?, S; Stari?, M; Steder, M; Sumiyoshi, T; Tamponi, U; Teramoto, Y; Trabelsi, K; Uchida, M; Uehara, S; Uglov, T; Unno, Y; Uno, S; Urquijo, P; Usov, Y; Van Hulse, C; Vanhoefer, P; Varner, G; Vinokurova, A; Vossen, A; Wagner, M N; Wang, C H; Wang, M -Z; Wang, P; Watanabe, M; Watanabe, Y; Williams, K M; Won, E; Yamamoto, H; Yashchenko, S; Yook, Y; Zhang, Z P; Zhilich, V; Zhulanov, V; Ziegler, M; Zupanc, A

    2015-01-01

    We report a measurement of the branching fraction of B^+ -> tau^+ nu_tau decays using a data sample of 772 x 10^6 BBbar pairs, collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^+e^- collider. We reconstruct the accompanying B meson in a semileptonic decay and detect the recoiling B candidate in the decay channel B^+ -> tau^+ nu_tau. We obtain a branching fraction of BR(B^+ -> tau^+ nu_tau) = [1.25 +- 0.28 (stat.) +- 0.27 (syst.)] x 10^-4. This result is in good agreement with previous measurements and the expectation from the calculation based on the Standard Model.

  12. Study of the tau- ---> pi- pi- pi+ pi0 pi0 nu/tau and tau- --> 3h- 2h+ nu/tau Decays Using the BaBar Detector

    SciTech Connect

    Sobie, R.; /Victoria U.

    2005-06-21

    The {tau}{sup -} {yields} {pi}{sup -}{pi}{sup -}{pi}{sup +}{pi}{sup 0}{pi}{sup 0}{nu}{sub {tau}} and {tau}{sup -} {yields} 3h{sup -} 2h{sup +} {nu}{sub {tau}} decays have been studied using the BABAR experiment at the PEP-II e{sup +}e{sup -} storage ring. Preliminary branching fractions are given for the {tau}{sup -} {yields} {pi}{sup -}{pi}{sup -}{pi}{sup +}{pi}{sup 0}{pi}{sup 0}{nu}{sub {tau}} and to the sub-channels {tau}{sup -} {yields} {eta}{pi}{sup -} {pi}{sup 0}{nu}{sub {tau}} and {tau}{sup -} {yields} {omega}(782){pi}{sup -}{pi}{sup 0}{nu}{sub {tau}}. A preliminary upper limit is given on the branching fraction for the {phi}(1020){pi}{sup -}{pi}{sup 0}{nu}{sub {tau}} mode. In addition a preliminary measurement of the branching fraction of the {tau}{sup -} {yields} 3h{sup -}2h{sup +} {nu}{sub {tau}} decay (h = {pi}, K) is presented.

  13. New limits for neutrinoless tau decays

    E-print Network

    Ammar, Raymond G.; Baringer, Philip S.; Bean, Alice; Besson, David Zeke; Coppage, Don; Darling, C.; Davis, Robin E. P.; Kotov, S.; Kravchenko, I.; Kwak, Nowhan; Zhou, L.

    1998-05-01

    -of-flight scintillation counters and a 7800- crystal CsI calorimeter. These elements are inside a 1.5 T superconducting solenoidal magnet whose iron yoke also serves as a hadron absorber for a muon identification system. Tau leptons were produced in pairs in e1e2...!; S. Jadach et al., ibid. 76, 361 ~1993!. @25# The CLEO II detector simulation is based on the GEANT soft- ware package: R. Brun et al., GEANT version 3.15, CERN DD/ EE/84-1.same sideband data for both signal region optimization and background...

  14. Observation of B{sup 0}{yields}D*{sup -}{tau}{sup +}{nu}{sub {tau}} Decay at Belle

    SciTech Connect

    Matyja, A.; Rozanska, M.; Bozek, A.; Lesiak, T.; Natkaniec, Z.; Palka, H. [H. Niewodniczanski Institute of Nuclear Physics, Krakow (Poland); Adachi, I.; Brodzicka, J.; Haba, J.; Hazumi, M.; Itoh, R.; Iwasaki, Y.; Katayama, N.; Kichimi, H.; Krokovny, P.; Nakamura, I.; Nakao, M.; Nishida, S.; Nozaki, T.; Ozaki, H. [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan)] (and others)

    2007-11-09

    We report an observation of the decay B{sup 0}{yields}D*{sup -}{tau}{sup +}{nu}{sub {tau}} in a data sample containing 535x10{sup 6} BB pairs collected with the Belle detector at the KEKB asymmetric-energy e{sup +}e{sup -} collider. We find a signal with a significance of 5.2{sigma} and measure the branching fraction B(B{sup 0}{yields}D*{sup -}{tau}{sup +}{nu}{sub {tau}})=(2.02{sub -0.37}{sup +0.40}(stat){+-}0.37(syst)) = %. This is the first observation of an exclusive B decay with a b{yields}c{tau}{nu}{sub {tau}} transition.

  15. Search for lepton flavor violating tau decays into leta, leta and lpi

    Microsoft Academic Search

    Y. Miyazaki; I. Adachi; H. Aihara; D. Anipko; K. Arinstein; V. Aulchenko; T. Aziz; A. M. Bakich; E. Barberio; A. Bay; I. Bedny; K. Belous; U. Bitenc; I. Bizjak; A. Bondar; M. Bracko; T. E. Browder; A. Chen; W. T. Chen; B. G. Cheon; Y. Choi; J. Dalseno; S. Eidelman; D. Epifanov; S. Fratina; N. Gabyshev; A. Go; A. Gorisek; H. Ha; J. Haba; K. Hayasaka; H. Hayashii; M. Hazumi; D. Heffernan; T. Hokuue; Y. Hoshi; S. Hou; W.-S. Hou; T. Iijima; A. Imoto; K. Inami; A. Ishikawa; R. Itoh; M. Iwasaki; Y. Iwasaki; H. Kaji; P. Kapusta; H. Kawai; T. Kawasaki; H. Kichimi; Y. J. Kim; S. Korpar; P. Krizan; P. Krokovny; R. Kulasiri; R. Kumar; C. C. Kuo; A. Kuzmin; Y.-J. Kwon; M. J. Lee; T. Lesiak; S.-W. Lin; F. Mandl; T. Matsumoto; H. Miyake; H. Miyata; T. Nagamine; Y. Nagasaka; M. Nakao; S. Nishida; O. Nitoh; S. Ogawa; T. Ohshima; S. Okuno; Y. Onuki; H. Ozaki; P. Pakhlov; G. Pakhlova; L. S. Peak; R. Pestotnik; L. E. Piilonen; A. Poluektov; H. Sahoo; Y. Sakai; N. Satoyama; T. Schietinger; O. Schneider; J. Schümann; C. Schwanda; A. J. Schwartz; K. Senyo; M. E. Sevior; H. Shibuya; B. Shwartz; V. Sidorov; J. B. Singh; A. Somov; N. Soni; S. Stanic; M. Staric; H. Stoeck; T. Sumiyoshi; F. Takasaki; K. Tamai; M. Tanaka; G. N. Taylor; Y. Teramoto; X. C. Tian; I. Tikhomirov; T. Tsukamoto; S. Uehara; K. Ueno; Y. Unno; S. Uno; P. Urquijo; Y. Usov; G. Varner; S. Villa; A. Vinokurova; C. H. Wang; M. Watanabe; Y. Watanabe; E. Won; A. Yamaguchi; Y. Yamashita; M. Yamauchi; Z. P. Zhang; V. Zhilich; V. Zhulanov; A. Zupanc

    2007-01-01

    We have searched for lepton-flavor-violating tau decays with a pseudoscalar meson (eta, eta and pi) using a data sample of 401 fb-1 collected with the Belle detector at the KEKB asymmetric-energy ee collider. No evidence for these decays is found and we set the following upper limits on the branching fractions: B(tau-->eeta)<9.2×10, B(tau-->mueta)<6.5×10, B(tau-->eeta)<1.6×10, B(tau-->mueta)<1.3×10, B(tau-->epi)<8.0×10 and B(tau-->mupi)<1.2×10 at the

  16. Study of High-multiplicity 3-prong and 5-prong Tau Decays at BaBar

    SciTech Connect

    Lees, J.P

    2012-06-01

    We present measurements of the branching fractions of 3-prong and 5-prong {tau} decay modes using a sample of 430 million {tau} lepton pairs, corresponding to an integrated luminosity of 468 fb{sup -1}, collected with the BABAR detector at the PEP-II asymmetric energy e{sup +}e{sup -} storage rings. The {tau}{sup -} {yields} (3{pi}){sup -} {eta}{nu}{sub {tau}}, {tau}{sup -} {yields} (3{pi}){sup -} {yields} {omega}{nu}{sub {tau}} and {tau}{sup -} {yields} {pi}{sup -} f{sub 1}(1285){nu}{sub {tau}} branching fractions are presented as well as a new limit on the branching fraction of the isospin-forbidden, second-class current {tau}{sup -} {yields} {pi}{sup -} {eta}{prime}(958){nu}{sub {tau}} decay. We find no evidence for charged kaons in these decay modes and place the first upper limits on their branching fractions.

  17. Search for Lepton Flavor Violating Decays Tau+- to L+- Omega

    SciTech Connect

    Schenk, S.; /Heidelberg U.

    2011-11-30

    This paper reports on a search for lepton flavor violating decays of a {tau} lepton to a lighter-mass charged lepton and an {omega} vector meson. The data sample corresponds to an integrated luminosity of 384 fb{sup -1} recorded by the BaBar experiment at the SLAC PEP-II asymmetric-energy B Factory. No evidence for a signal is found and the upper limits on the branching ratios are determined to be B({tau}{sup {+-}} {yields} e{sup {+-}}{omega}) < 1.1 x 10{sup -7} and B({tau}{sup {+-}} {yields} {mu}{sup {+-}}{omega}) < 1.0 x 10{sup -7} at 90% confidence level.

  18. Study of tau decays to four-hadron final states with kaons

    E-print Network

    Besson, David Zeke

    2005-06-01

    measurements of B(tau(-)-> K(-)pi(+)pi(-)pi(0)nu(tau),excludingK(0))=(7.4 +/- 0.8 +/- 1.1)x10(-4) and B(tau(-)-> K(-)K(+)pi(-)pi(0)nu(tau))=(5.5 +/- 1.4 +/- 1.2)x10(-5) are presented, including the first observation of the decay tau(-)-> K(-)omega nu...

  19. Search for CP Violation in the Decay tau- \\to pi- K^0_S (>= 0 pi0) nu_tau

    SciTech Connect

    Lees, J.P.; Poireau, V.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; /INFN, Bari /Bari U.; Milanes, D.A.; /INFN, Bari; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; /Bergen U.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; /UC, Berkeley; Koch, H.; Schroeder, T.; /Ruhr U., Bochum; Asgeirsson, D.J.; Hearty, C.; Mattison, T.S.; McKenna, J.A.; /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Paris U., VI-VII /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /Pisa U. /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas Nuclear Corp., Austin /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2012-02-16

    We report a search for CP violation in the decay {tau}{sup -} {yields} {pi}{sup -}K{sub S}{sup 0}({>=} 0{pi}{sup 0}){nu}{sub {tau}} using a dataset of 437 million {tau} lepton pairs, corresponding to an integrated luminosity of 476 fb{sup -1}, collected with the BABAR detector at the PEP-II asymmetric energy e{sup +}e{sup -} storage rings. The CP-violating decay-rate asymmetry is determined to be (-0.45 {+-} 0.24 {+-} 0.11)%, approximately three standard deviations from the Standard Model prediction of (0.33 {+-} 0.01)%.

  20. A measurement of tau polarization in Z0 decays

    Microsoft Academic Search

    O. Adriani; M. Aguilar-Benitez; S. P. Ahlen; H. Akbari; J. Alcaraz; A. Aloisio; G. Alverson; M. G. Alviggi; G. Ambrosi; Q. An; H. Anderhub; A. L. Anderson; V. P. Andreev; T. Angelov; L. Antonov; D. Antreasyan; P. Arce; A. Arefiev; A G Atamanchuk; T. Azemoon; T. Aziz; P. V. K. S. Baba; P. Bagnaia; J. A. Bakken; L. Baksay; R. C. Ball; S. Banerjee; J. Bao; R. Barillère; L. Barone; A. Baschirotto; R. Battiston; A. Bay; F. Becattini; U. Becker; F. Behner; J. Behrens; S. Beingessner; Gy. L. Bencze; J. Berdugo; P. Berges; B. Bertucci; B. L. Betev; M. Biasini; A. Biland; G. M. Bilei; R. Bizzarri; J. J. Blaising; B. Blumenfeld; Gerjan J Bobbink; M. Bocciolini; R K Böck; A. Böhm; B. Borgia; M Bosetti; D. Bourilkov; Maurice Bourquin; D. Boutigny; B T Bouwens; Elena Brambilla; J. G. Branson; I. C. Brock; M. Brooks; C. Buisson; A T Bujak; J. D. Burger; W. J. Burger; J. P. Burq; J K Busenitz; X. D. Cai; M. Capell; M. Caria; G. Carlino; F. Carminati; A. M. Cartacci; R. Castello; M Cerrada-Canales; F. Cesaroni; Y. H. Chang; U. K. Chaturvedi; M. Chemarin; A. Chen; C. Chen; G. M. Chen; H. F. Chen; H. S. Chen; J. Chen; M. Chen; W. Y. Chen; G. Chiefari; C. Y. Chien; M. Chmeissani; M. T. Choi; S. Chung; C. Civinini; I. Clare; R. Clare; T. E. Coan; H. O. Cohn; G. Coignet; N. Colino; A. Contin; F. Crijns; X. T. Cui; X. Y. Cui; T. S. Dai; R. D'Alessandro; R. de Asmundis; A. Degré; K. Deiters; E. Dénes; P. Denes; F. Denotaristefani; M. Dhina; D. Dibitonto; M. Diemoz; H. R. Dimitrov; C. Dionisi; M. T. Dova; E. Drago; T. Driever; D. Duchesneau; P. Duinker; I. Duran; S. Easo; H. El Mamouni; A. Engler; F. J. Eppling; F. C. Erné; P. Extermann; R. Fabbretti; M. Fabre; S. Falciano; S. J. Fan; O. Fackler; J. Fay; M. Felcini; T. Ferguson; D. Fernandez; G. Fernandez; F. Ferroni; H. Fesefeldt; E. Fiandrini; J. Field; F. Filthaut; G. Finocchiaro; P. H. Fisher; G. Forconi; T. Foreman; K. Freudenreich; W. Friebel; M. Fukushima; M. Gailloud; Yu. Galaktionov; E. Gallo; S. N. Ganguli; P. Garcia-Abia; S Gentile; D. Gele; S. Goldfarb; Z. F. Gong; E. Gonzalez; P. Göttlicher; A. Gougas; D. Goujon; G. Gratta; C. Grinnell; M. Gruenewald; C. Gu; M. Guanziroli; J. K. Guo; V. K. Gupta; A. Gurtu; H. R. Gustafson; L. J. Gutay; K. Hangarter; A. Hasan; D. Hauschildt; C. F. He; T. Hebbeker; M. Hebert; G. Herten; U. Herten; A. Hervé; K. Hilgers; H. Hofer; H. Hoorani; G. Hu; B. Ille; M. M. Ilyas; V. Innocente; H. Janssen; S. Jezequel; B. N. Jin; L. W. Jones; A. Kasser; R. A. Khan; Yu. Kamyshkov; P. Kapinos; J. S. Kapustinsky; Y. Karyotakis; M N Kienzle-Focacci; S. Khokar; J. K. Kim; S. C. Kim; Y. G. Kim; W. W. Kinnison; D. Kirkby; S. Kirsch; W. Kittel; A Koulbardis; A. C. König; E. Koffeman; O. Kornadt; V. Koutsenko; R. W. Kraemer; T. Kramer; V. R. Krastev; W. Krenz; A. Krivshich; H. Kuijten; K. S. Kumar; A. Kunin; G. Landi; D. Lanske; S. Lanzano; P. Lebrun; P. Lecomte; P. Lecoq; P. Le Coultre; D. M. Lee; I. Leedom; J. M. Le Goff; R. Leiste; M. Lenti; E. Leonardi; J. Lettry; X. Leytens; C. Li; H. T. Li; P. J. Li; X. G. Li; J. Y. Liao; W. T. Lin; Z. Y. Lin; F. L. Linde; B. Lindemann; D. Linnhofer; L. Lista; Y. Liu; W. Lohmann; E. Longo; Y. S. Lu; J. M. Lubbers; K. Lübelsmeyer; C. Luci; D. Luckey; L. Ludovici; L. Luminari; W. Lustermann; J. M. Ma; W. G. Ma; M. MacDermott; P. K. Malhotra; R. Malik; A. Malinin; C. Mãna; D. N. Mao; Y. F. Mao; M. Maolinbay; P. Marchesini; F. Marion; A. Marin; J. P. Martin; L. Martinez-Laso; F. Marzano; G. G. G. Massaro; T Meinholz; K. Mazumdar; P. McBride; T. McMahon; D. McNally; M. Merk; L. Merola; M. Meschini; W. J. Metzger; Y. Mi; G. B. Mills; Y. Mir; G. Mirabelli; J. Mnich; M. Möller; B. Monteleoni; R. Morand; S. Morganti; N. E. Moulai; R. Mount; S. Müller; A. Nadtochy; E. Nagy; M. Napolitano; H. Newman; C. Neyer; M. A. Niaz; A. Nippe; H. Nowak; G. Organtini; D. Pandoulas; S. Paoletti; P. Paolucci; G. Passaleva; S. Patricelli; T. Paul; M. Pauluzzi; F. Pauss; Y. J. Pei; S. Pensotti; D. Perret-Gallix; J. Perrier; A. Pevsner; D. Piccolo; M. Peiri; P. A. Piroué; F. Plasil; V. Plyaskin; M. Pohl; V. Pojidaev; N. Produit; J. M. Qian; K. N. Qureshi; R. Raghavan; G. Rahal-Callot; P. G. Rancoita; M. Rattaggi; G. Raven; P. Razis; K. Read; D. Ren; Z. Ren; M. Rescigno; S. Reucroft; A. Ricker; S. Riemann; W. Riemers; O. Rind; H. A. Rizvi; F. J. Rodriguez; B. P. Roe; M. Röhner; S. Röhner; L. Romero; J. Rose; S. Rosier-Lees; R. Rosmalen; Ph. Rosselet; A. Rubbia; J. A. Rubio; H. Rykaczewski; M. Sachwitz; E. Sajan; J. Salicio; G. S. Sanders; A. Santocchia; M. S. Sarakinos; G. Sartorelli; M. Sassowsky; G. Sauvage; V. Schegelsky; K. Schmiemann; D. Schmitz; P. Schmitz; M. Schneegans; H. Schopper; D. J. Schotanus; S. Shotkin; H. J. Schreiber; J Schwenke; R. Schulte; S. Schulte; K. Schultze; J. Schütte; G. Schwering; C. Sciacca; I. Scott; R. Sehgal; P. G. Seiler; J. C. Sens; L. Servoli; I. Sheer; D. Z. Shen

    1992-01-01

    The polarization of tau leptons produced in e+e- --> tau+tau-(gamma) is measured using a sample of 8977 tau+tau - pairs collected near the peak of the Z0 resonance. A polarization of -0.132+\\/-0.026(stat)+\\/-0.021(syst.) is determined. This corresponds to a ratio of the vector to the axial-vector coupling constants of the tau lepton to the weak neutral current of gVtau\\/gAefftau = 0.067+\\/-0.017.

  1. Improved measurement of psi(2S) decays into tau+tau-

    Microsoft Academic Search

    M. Ablikim; J. Z. Bai; Y. Ban; J. G. Bian; X. Cai; H. F. Chen; H. S. Chen; H. X. Chen; J. C. Chen; Y. B. Chen; S. P. Chi; Y. P. Chu; X. Z. Cui; Y. S. Dai; L. Y. Diao; Z. Y. Deng; Q. F. Dong; S. X. Du; J. Fang; S. S. Fang; C. D. Fu; C. S. Gao; Y. N. Gao; S. D. Gu; Y. T. Gu; Y. N. Guo; Y. Q. Guo; Z. J. Guo; F. A. Harris; K. L. He; M. He; Y. K. Heng; H. M. Hu; T. Hu; G. S. Huang; X. T. Huang; X. B. Ji; X. S. Jiang; X. Y. Jiang; J. B. Jiao; D. P. Jin; S. Jin; Yi Jin; Y. F. Lai; G. Li; H. B. Li; H. H. Li; J. Li; R. Y. Li; S. M. Li; W. D. Li; W. G. Li; X. L. Li; X. N. Li; X. Q. Li; Y. L. Li; Y. F. Liang; H. B. Liao; B. J. Liu; C. X. Liu; F. Liu; Fang Liu; H. H. Liu; H. M. Liu; J. Liu; J. P. Liu; Q. Liu; R. G. Liu; Z. A. Liu; Y. C. Lou; F. Lu; G. R. Lu; J. G. Lu; C. L. Luo; F. C. Ma; H. L. Ma; L. L. Ma; Q. M. Ma; X. B. Ma; Z. P. Mao; X. H. Mo; J. Nie; S. L. Olsen; H. P. Peng; R. G. Ping; N. D. Qi; H. Qin; J. F. Qiu; Z. Y. Ren; G. Rong; L. Y. Shan; L. Shang; C. P. Shen; D. L. Shen; X. Y. Shen; H. Y. Sheng; H. S. Sun; J. F. Sun; S. S. Sun; Y. Z. Sun; Z. J. Sun; Z. Q. Tan; X. Tang; G. L. Tong; G. S. Varner; D. Y. Wang; L. L. Wang; L. S. Wang; M. Wang; P. Wang; W. F. Wang; Y. F. Wang; Z. Wang; Zheng Wang; C. L. Wei; D. H. Wei; N. Wu; X. M. Xia; X. X. Xie; G. F. Xu; X. P. Xu; Y. Xu; M. L. Yan; H. X. Yang; Y. X. Yang; M. H. Ye; Y. X. Ye; Z. Y. Yi; G. W. Yu; C. Z. Yuan; J. M. Yuan; Y. Yuan; S. L. Zang; Y. Zeng; Yu Zeng; B. X. Zhang; C. C. Zhang; D. H. Zhang; H. Q. Zhang; H. Y. Zhang; J. W. Zhang; J. Y. Zhang; S. H. Zhang; X. M. Zhang; X. Y. Zhang; Yiyun Zhang; Z. P. Zhang; D. X. Zhao; J. W. Zhao; M. G. Zhao; P. P. Zhao; W. R. Zhao; Z. G. Zhao; H. Q. Zheng; J. P. Zheng; Z. P. Zheng; L. Zhou; N. F. Zhou; K. J. Zhu; Q. M. Zhu; Y. C. Zhu; Y. S. Zhu; Yingchun Zhu; Z. A. Zhu; B. A. Zhuang; X. A. Zhuang; B. S. Zou

    2006-01-01

    Using 14M psi(2S) events collected at BESII, the branching fraction of psi(2S)-->tau+tau- is measured to be Brtautau=(3.08±0.21±0.38)×10-3, where the first error is statistical and the second is systematic.

  2. Order alphas4 QCD corrections to Z and tau decays.

    PubMed

    Baikov, P A; Chetyrkin, K G; Kühn, J H

    2008-07-01

    Using recently developed methods for the evaluation of five-loop amplitudes in perturbative QCD, corrections of order alphas4 for the nonsinglet part of the cross section for electron-positron annihilation into hadrons and for the decay rates of the Z boson and the tau lepton into hadrons are evaluated. The new terms lead to a significant stabilization of the perturbative series, to a reduction of the theory uncertainly in the strong coupling constant alphas, as extracted from these measurements, and to a small shift of the central value, moving the two central values closer together. The agreement between two values of alphas measured at vastly different energies constitutes a striking test of asymptotic freedom. Combining the results from Z and tau decays we find alphas(MZ)=0.1198+/-0.0015 as one of the most precise and presently only result for the strong coupling constant in order alphas4. PMID:18764104

  3. Measurement of the tau- to eta pi-pi+pi-nu tau Branching Fraction and a Search for a Second-Class Current in the tau- to eta'(958)pi-nu tau Decay

    SciTech Connect

    Aubert, B.; Bona, M.; Boutigny, D.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prudent, X.; Tisserand, V.; Zghiche, A.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Lopez, L.; Palano, A.; Pappagallo, M.; /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Abrams, G.S.; Battaglia, M.; Brown, David Nathan; Button-Shafer, J.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /Bristol U. /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /Ferrara U. /Frascati /Genoa U. /Harvard U. /Heidelberg U. /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Karlsruhe U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /Milan U. /INFN, Milan /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /Padua U. /Paris U., VI-VII /Pennsylvania U. /Perugia U. /Pisa U. /Princeton U. /INFN, Rome /Rostock U. /Rutherford /DSM, DAPNIA, Saclay /South Carolina U. /SLAC /Stanford U., Phys. Dept. /SUNY, Albany /Tennessee U. /Texas U. /Texas U., Dallas /Turin U. /INFN, Turin /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison /Yale U.

    2008-03-24

    The {tau}{sup -} {yields} {eta}{pi}{sup -}{pi}{sup +}{pi}{sup -}{nu}{sub {tau}} decay with the {eta} {yields} {gamma}{gamma} mode is studied using 384 fb{sup -1} of data collected by the BABAR detector. The branching fraction is measured to be (1.60 {+-} 0.05 {+-} 0.11) x 10{sup -4}. It is found that {tau}{sup -} {yields} f{sub 1}(1285){pi}{sup -} {nu}{sub {tau}} {yields} {eta}{pi}{sup -}{pi}{sup +}{pi}{sup -}{nu}{sub {tau}} is the dominant decay mode with a branching fraction of (1.11 {+-} 0.06 {+-} 0.05) x 10{sup -4}. The first error on the branching fractions is statistical and the second systematic. In addition, a 90% confidence level upper limit on the branching fraction of the {tau}{sup -} {yields} {eta}{prime}(958){pi}{sup -}{nu}{sub {tau}} decay is measured to be 7.2 x 10{sup -6}. This last decay proceeds through a second-class current and is expected to be forbidden in the limit of isospin symmetry.

  4. Search for charged Higgs boson decays of the top quark using hadronic tau decays

    Microsoft Academic Search

    F. Abe; H. Akimoto; A. Akopian; M. G. Albrow; S. R. Amendolia; D. Amidei; J. Antos; C. Anway-Wiese; S. Aota; G. Apollinari; T. Asakawa; W. Ashmanskas; M. Atac; P. Auchincloss; F. Azfar; P. Azzi-Bacchetta; N. Bacchetta; W. Badgett; S. Bagdasarov; M. W. Bailey; J. Bao; P. de Barbaro; A. Barbaro-Galtieri; V. E. Barnes; B. A. Barnett; G. Bauer; T. Baumann; F. Bedeschi; S. Behrends; S. Belforte; G. Bellettini; J. Bellinger; D. Benjamin; J. Benlloch; J. Bensinger; D. Benton; A. Beretvas; J. P. Berge; J. Berryhill; S. Bertolucci; A. Bhatti; K. Biery; M. Binkley; D. Bisello; R. E. Blair; C. Blocker; A. Bodek; W. Bokhari; V. Bolognesi; D. Bortoletto; J. Boudreau; L. Breccia; C. Bromberg; N. Bruner; E. Buckley-Geer; H. S. Budd; K. Burkett; G. Busetto; A. Byon-Wagner; K. L. Byrum; J. Cammerata; C. Campagnari; M. Campbell; A. Caner; W. Carithers; D. Carlsmith; A. Castro; D. Cauz; Y. Cen; F. Cervelli; H. Y. Chao; J. Chapman; M.-T. Cheng; G. Chiarelli; T. Chikamatsu; C. N. Chiou; L. Christofek; S. Cihangir; A. G. Clark; M. Cobal; M. Contreras; J. Conway; J. Cooper; M. Cordelli; C. Couyoumtzelis; D. Crane; D. Cronin-Hennessy; R. Culbertson; J. D. Cunningham; T. Daniels; F. Dejongh; S. Delchamps; S. dell'agnello; M. dell'orso; L. Demortier; B. Denby; M. Deninno; P. F. Derwent; T. Devlin; M. Dickson; J. R. Dittmann; S. Donati; J. Done; T. Dorigo; A. Dunn; N. Eddy; K. Einsweiler; J. E. Elias; R. Ely; E. Jr. Engels; D. Errede; S. Errede; Q. Fan; I. Fiori; B. Flaugher; G. W. Foster; M. Franklin; M. Frautschi; J. Freeman; J. Friedman; H. Frisch; T. A. Fuess; Y. Fukui; S. Funaki; G. Gagliardi; S. Galeotti; M. Gallinaro; M. Garcia-Sciveres; A. F. Garfinkel; C. Gay; S. Geer; D. W. Gerdes; P. Giannetti; N. Giokaris; P. Giromini; L. Gladney; D. Glenzinski; M. Gold; J. Gonzalez; A. Gordon; A. T. Goshaw; K. Goulianos; H. Grassmann; L. Groer; C. Grosso-Pilcher; G. Guillian; R. S. Guo; C. Haber; E. Hafen; S. R. Hahn; R. Handler; R. M. Hans; K. Hara; A. D. Hardman; B. Harral; R. M. Harris; S. A. Hauger; J. Hauser; C. Hawk; E. Hayashi; J. Heinrich; K. D. Hoffman; M. Hohlmann; C. Holck; R. Hollebeek; L. Holloway; A. Hölscher; S. Hong; G. Houk; P. Hu; B. T. Huffman; R. Hughes; J. Huston; J. Huth; J. Hylen; H. Ikeda; M. Incagli; J. Incandela; G. Introzzi; J. Iwai; Y. Iwata; H. Jensen; U. Joshi; R. W. Kadel; E. Kajfasz; T. Kamon; T. Kaneko; K. Karr; H. Kasha; Y. Kato; L. Keeble; K. Kelley; R. D. Kennedy; R. Kephart; P. Kesten; D. Kestenbaum; R. M. Keup; H. Keutelian; F. Keyvan; B. Kharadia; B. J. Kim; D. H. Kim; H. S. Kim; S. B. Kim; S. H. Kim; Y. K. Kim; L. Kirsch; P. Koehn; K. Kondo; J. Konigsberg; S. Kopp; K. Kordas; W. Koska; E. Kovacs; W. Kowald; M. Krasberg; J. Kroll; M. Kruse; T. Kuwabara; S. E. Kuhlmann; E. Kuns; A. T. Laasanen; N. Labanca; S. Lammel; J. I. Lamoureux; T. Lecompte; S. Leone; J. D. Lewis; P. Limon; M. Lindgren; T. M. Liss; N. Lockyer; O. Long; C. Loomis; M. Loreti; J. Lu; D. Lucchesi; P. Lukens; S. Lusin; J. Lys; K. Maeshima; A. Maghakian; P. Maksimovic; M. Mangano; J. Mansour; M. Mariotti; J. P. Marriner; A. Martin; J. A. Matthews; R. Mattingly; P. McIntyre; P. Melese; A. Menzione; E. Meschi; S. Metzler; C. Miao; G. Michail; R. Miller; H. Minato; S. Miscetti; M. Mishina; H. Mitsushio; T. Miyamoto; S. Miyashita; Y. Morita; J. Mueller; A. Mukherjee; T. Muller; P. Murat; H. Nakada; I. Nakano; C. Nelson; D. Neuberger; C. Newman-Holmes; M. Ninomiya; L. Nodulman; S. H. Oh; K. E. Ohl; T. Ohmoto; T. Ohsugi; R. Oishi; M. Okabe; T. Okusawa; R. Oliver; J. Olsen; C. Pagliarone; R. Paoletti; V. Papadimitriou; S. P. Pappas; A. Parri; J. Patrick; G. Pauletta; M. Paulini; A. Perazzo; L. Pescara; M. D. Peters; T. J. Phillips; G. Piacentino; M. Pillai; K. T. Pitts; R. Plunkett; L. Pondrom; J. Proudfoot; F. Ptohos; G. Punzi; K. Ragan; A. Ribon; F. Rimondi; L. Ristori; W. J. Robertson; T. Rodrigo; S. Rolli; J. Romano; L. Rosenson; R. Roser; W. K. Sakumoto; D. Saltzberg; A. Sansoni; L. Santi; H. Sato; V. Scarpine; P. Schlabach; E. E. Schmidt; M. P. Schmidt; A. Scribano; S. Segler; S. Seidel; Y. Seiya; G. Sganos; A. Sgolacchia; M. D. Shapiro; N. M. Shaw; Q. Shen; P. F. Shepard; M. Shimojima; M. Shochet; J. Siegrist; A. Sill; P. Sinervo; P. Singh; J. Skarha; K. Sliwa; F. D. Snider; T. Song; J. Spalding; P. Sphicas; F. Spinella; M. Spiropulu; L. Spiegel; L. Stanco; J. Steele; A. Stefanini; K. Strahl; J. Strait; R. Ströhmer; D. Stuart; G. Sullivan; A. Soumarokov; K. Sumorok; J. Suzuki; T. Takada; T. Takahashi; T. Takano; K. Takikawa; N. Tamura; F. Tartarelli; W. Taylor; P. K. Teng; Y. Teramoto; S. Tether; D. Theriot; T. L. Thomas; R. Thun; M. Timko; P. Tipton; A. Titov; S. Tkaczyk; D. Toback; K. Tollefson; A. Tollestrup; J. Tonnison; J. F. de Troconiz; S. Truitt; J. Tseng; N. Turini; T. Uchida; N. Uemura; F. Ukegawa; G. Unal; S. C. Brink; S. Vejcik; G. Velev; R. Vidal; M. Vondracek; D. Vucinic; R. G. Wagner; R. L. Wagner; J. Wahl

    1996-01-01

    We present the result of a search for charged Higgs boson decays of the top quark, produced in pp¯ collisions at &surd;s=1.8 TeV. When the charged Higgs boson is heavy and decays to a tau lepton, which subsequently decays hadronically, the resulting events have a unique signature: large missing transverse energy and the low-charged-multiplicity tau. Data collected in 1992 and

  5. Update of the search for the neutrinoless decay tau-->mugamma

    Microsoft Academic Search

    S. Ahmed; M. S. Alam; S. B. Athar; L. Jian; L. Ling; A. H. Mahmood; M. Saleem; S. Timm; F. Wappler; A. Anastassov; J. E. Duboscq; K. K. Gan; C. Gwon; T. Hart; K. Honscheid; H. Kagan; R. Kass; J. Lorenc; T. K. Pedlar; H. Schwarthoff; E. von Toerne; M. M. Zoeller; S. J. Richichi; H. Severini; P. Skubic; A. Undrus; S. Chen; J. Fast; J. W. Hinson; J. Lee; N. Menon; D. H. Miller; E. I. Shibata; I. P. Shipsey; V. Pavlunin; D. Cronin-Hennessy; Y. Kwon; A. L. Lyon; E. H. Thorndike; C. P. Jessop; H. Marsiske; M. L. Perl; V. Savinov; D. Ugolini; X. Zhou; T. E. Coan; V. Fadeyev; I. Korolkov; Y. Maravin; I. Narsky; R. Stroynowski; J. Ye; T. Wlodek; M. Artuso; R. Ayad; E. Dambasuren; S. Kopp; G. Majumder; G. C. Moneti; S. Schuh; T. Skwarnicki; S. Stone; G. Viehhauser; J. C. Wang; A. Wolf; J. Wu; S. E. Csorna; K. W. McLean; Sz. Márka; Z. Xu; R. Godang; K. Kinoshita; I. C. Lai; S. Schrenk; G. Bonvicini; D. Cinabro; L. P. Perera; G. J. Zhou; G. Eigen; E. Lipeles; M. Schmidtler; A. Shapiro; W. M. Sun; A. J. Weinstein; F. Würthwein; D. E. Jaffe; G. Masek; H. P. Paar; E. M. Potter; S. Prell; V. Sharma; D. M. Asner; A. Eppich; J. Gronberg; T. S. Hill; D. J. Lange; R. J. Morrison; H. N. Nelson; R. A. Briere; B. H. Behrens; W. T. Ford; A. Gritsan; J. Roy; J. G. Smith; J. P. Alexander; R. Baker; C. Bebek; B. E. Berger; K. Berkelman; F. Blanc; V. Boisvert; D. G. Cassel; M. Dickson; P. S. Drell; K. M. Ecklund; R. Ehrlich; A. D. Foland; P. Gaidarev; R. S. Galik; L. Gibbons; B. Gittelman; S. W. Gray; D. L. Hartill; B. K. Heltsley; P. I. Hopman; C. D. Jones; D. L. Kreinick; M. Lohner; T. O. Meyer; N. B. Mistry; C. R. Ng; E. Nordberg; J. R. Patterson; D. Peterson; D. Riley; J. G. Thayer; P. G. Thies; B. Valant-Spaight; A. Warburton; P. Avery; C. Prescott; A. I. Rubiera; J. Yelton; J. Zheng; G. Brandenburg; A. Ershov; Y. S. Gao; D. Y.-J. Kim; R. Wilson; T. E. Browder; Y. Li; J. L. Rodriguez; H. Yamamoto; T. Bergfeld; B. I. Eisenstein; J. Ernst; G. E. Gladding; G. D. Gollin; R. M. Hans; E. Johnson; I. Karliner; M. A. Marsh; M. Palmer; C. Plager; C. Sedlack; M. Selen; J. J. Thaler; J. Williams; K. W. Edwards; R. Janicek; P. M. Patel; A. J. Sadoff; R. Ammar; P. Baringer; A. Bean; D. Besson; R. Davis; I. Kravchenko; N. Kwak; X. Zhao; S. Anderson; V. V. Frolov; Y. Kubota; S. J. Lee; R. Mahapatra; J. J. O'neill; R. Poling; T. Riehle; A. Smith; J. Urheim

    2000-01-01

    We present an update of the search for the lepton family number violating decay tau-->mugamma using 12.6 million tau+tau- pairs collected with the CLEO detector. No evidence of a signal has been found and the corresponding upper limit is B(tau-->mugamma)<1.1×10-6 at 90% C.L., significantly smaller than previous experimental limits.

  6. Decay properties of tau leptons measured at the Z0 resonance

    Microsoft Academic Search

    B. Adeva; O. Adriani; M. Aguilar-Benitez; H. Akbari; J. Alcaraz; A. Aloisio; G. Alverson; M. G. Alviggi; G. Ambrosi; Q. An; H. Anderhub; A. L. Anderson; V. P. Andreev; T. Angelov; L. Antonov; D. Antreasyan; P. Arce; A. Arefiev; T. Azemoon; P. V. K. S. Baba; P. Bagnaia; J. A. Bakken; L. Baksay; R. C. Ball; S. Banerjee; J. Bao; R. Barillère; L. Barone; R. Battiston; A. Bay; U. Becker; F. Behner; J. Behrens; S. Beingessner; Gy. L. Bencze; J. Berdugo; P. Berges; B. Bertucci; A. Biland; G. M. Bilei; R. Bizzarri; J. J. Blaising; P. Blömeke; B. Blumenfeld; G. J. Bobbink; M. Bocciolini; R. Bock; A. Böhm; B. Borgia; D. Bourilkov; M. Bourquin; D. Boutigny; B. Bouwens; J. G. Branson; I. C. Brock; F. Bruyant; C. Buisson; A. Bujak; J. D. Burger; J. Busenitz; X. D. Cai; M. Capell; F. Carbonara; M. Caria; F. Carminati; A. M. Cartacci; M. Cerrada; Y. H. Chang; U. K. Chaturvedi; M. Chemarin; A. Chen; C. Chen; G. M. Chen; H. F. Chen; H. S. Chen; M. Chen; W. Y. Chen; G. Chiefari; C. Y. Chien; M. Chmeissani; C. Civinini; I. Clare; R. Clare; H. O. Cohn; G. Coignet; N. Colino; V. Commichau; G. Conforto; A. Contin; F. Crijns; X. Y. Cui; T. S. Dai; R. D'Alessandro; R. de Asmundis; A. Degré; K. Dénes; P. Denes; F. Denotaristefani; M. Dhina; D. Dibitonto; M. Diemoz; H. R. Dimitrov; C. Dionisi; E. Drago; T. Driever; D. Duchesneau; P. Duinker; I. Duran; H. El Mamouni; A. Engler; F. J. Eppling; F. C. Erné; P. Extermann; R. Fabbretti; M. Fabre; S. Falciano; Q. Fan; S. J. Fan; O. Fackler; J. Fay; T. Ferguson; G. Fernandez; F. Ferroni; H. Fesefeldt; E. Fiandrini; J. Field; F. Filthaut; G. Finocchiaro; P. H. Fisher; G. Forconi; T. Foreman; K. Freudenreich; W. Friebel; M. Fukushima; M. Gailloud; Yu. Galaktionov; E. Gallo; S. N. Ganguli; P. Garcia-Abia; S. S. Gau; D. Gele; S. Gentile; M. Glaubman; S. Goldfarb; Z. F. Gong; E. Gonzalez; A. Gordeev; P. Göttlicher; D. Goujon; G. Gratta; C. Grinnell; M. Gruenewald; M. Guanziroli; J. K. Guo; A. Gurtu; H. R. Gustafson; L. J. Gutay; H. Haan; A. Hasan; D. Hauschildt; C. F. He; T. Hebbeker; M. Hebert; G. Herten; U. Herten; A. Hervé; K. Hilgers; H. Hofer; H. Hoorani; L. S. Hsu; G. Hu; B. Ille; M. M. Ilyas; V. Innocente; H. Janssen; S. Jezequel; B. N. Jin; L. W. Jones; A. Kasser; R. A. Khan; Yu. Kamyshkov; Y. Karyotakis; M. Kaur; S. Khokhar; V. Khoze; M. N. Kienzle-Focacci; W. Kinnison; D. Kirkby; W. Kittel; A. Klimentov; A. C. König; O. Kornadt; V. Koutsenko; R. W. Kraemer; T. Kramer; V. R. Krastev; W. Krenz; J. Krizmanic; K. S. Kumar; A. Kunin; V. Lalieu; G. Landi; K. Lanius; D. Lanske; S. Lanzano; P. Lebrun; P. Lecomte; P. Lecoq; P. Le Coultre; D. Lee; I. Leedom; J. M. Le Goff; L. Leistam; R. Leiste; M. Lenti; E. Leonardi; J. Lettry; P. M. Levchenko; X. Leytens; C. Li; H. T. Li; J. F. Li; L. Li; P. J. Li; Q. Li; X. G. Li; J. Y. Liao; Z. Y. Lin; F. L. Linde; B. Lindemann; D. Linnhofer; R. Liu; Y. Liu; W. Lohmann; E. Longo; Y. S. Lu; J. M. Lubbers; K. Lübelsmeyer; C. Luci; D. Luckey; L. Ludovici; L. Luminari; W. G. Ma; M. MacDermott; R. Magahiz; P. K. Malhotra; R. Malik; A. Malinin; C. Maña; D. N. Mao; Y. F. Mao; M. Maolinbay; P. Marchesini; A. Marchionni; J. P. Martin; L. Martinez-Laso; F. Marzano; G. G. G. Massaro; T. Matsuda; K. Mazumdar; P. McBride; T. McMahon; D. McNally; Th. Meinholz; M. Merk; L. Merola; M. Meschini; W. J. Metzger; Y. Mi; G. B. Mills; Y. Mir; G. Mirabelli; J. Mnich; M. Möller; B. Monteleoni; G. Morand; R. Morand; S. Morganti; N. E. Moulai; R. Mount; S. Müller; E. Nagy; M. Napolitano; H. Newman; C. Neyer; M. A. Niaz; L. Niessen; H. Nowak; D. Pandoulas; M. Pauluzzi; F. Pauss; F. Plasil; G. Passaleva; G. Paternoster; S. Patricelli; Y. J. Pei; D. Perret-Gallix; J. Perrier; A. Pevsner; M. Pieri; P. A. Piroué; V. Plyaskin; M. Pohl; V. Pojidaev; N. Produit; J. M. Qian; K. N. Qureshi; R. Raghavan; G. Rahal-Callot; G. Raven; P. Razis; K. Read; D. Ren; Z. Ren; S. Reucroft; A. Ricker; S. Riemann; O. Rind; C. Rippich; H. A. Rizvi; B. P. Roe; M. Röhner; S. Röhner; L. Romero; J. Rose; S. Rosier-Lees; R. Rosmalen; Ph. Rosselet; A. Rubbia; J. A. Rubio; W. Ruckstuhl; H. Rykaczewski; M. Sachwitz; J. Salicio; G. Sanders; A. Santocchia; M. S. Sarakinos; G. Sartorelli; G. Sauvage; A. Savin; V. Schegelsky; K. Schmiemann; D. Schmitz; P. Schmitz; M. Schneegans; H. Schopper; D. J. Schotanus; S. Shotkin; H. J. Schreiber; R. Schulte; S. Schulte; K. Schultze; J. Schütte; J. Schwenke; G. Schwering; C. Sciacca; I. Scott; R. Sehgal; P. G. Seiler; L. Servoli; I. Sheer; D. Z. Shen; V. Shevchenko; S. Shevchenko; X. R. Shi; K. Shmakov; V. Shoutko; E. Shumilov; N. Smirnov; E. Soderstrom; A. Sopczak; C. Spartiotis; T. Spickermann; P. Spillantini; R. Starosta; M. Steuer; D. P. Stickland; F. Sticozzi; W. Stoeffl; H. Stone; K. Strauch; B. C. Stringfellow; K. Sudhakar; G. Sultanov; R. L. Summer; L. Z. Sun; H. Suter; R. B. Sutton; J. D. Swain; A. A. Syed; X. W. Tang; E. Tarkovsky

    1991-01-01

    From 2540 Z0 --> tau+tau- events, we determine the inclusive decay branching fractions of the tau-lepton into one and three charged particles to be 0.856 +\\/- 0.006 (stat.) +\\/- 0.003 (syst.) and 0.144 +\\/- 0.006 (stat.) +\\/- 0.003 (syst.), respectively. The leptonic branching fractions are measured to be 0.175 +\\/- 0.008 (stat.) +\\/- 0.005 (syst.) for tau --> munumunutau and

  7. Measurement of the Michel parameters and the average tau-neutrino helicity from tau decays at LEP

    Microsoft Academic Search

    M. Acciarri; O. Adriani; M. Aguilar-Benitez; S P Ahlen; J. Alcaraz; G. Alemanni; James V Allaby; A. Aloisio; M. G. Alviggi; M. G. Alviggi; H. Anderhub; V. P. Andreev; T. Angelescu; F. Anselmo; A. Arefiev; T. Azemoon; T. Azemoon; P. Bagnaia; L. Baksay; R. C. Ball; S. Banerjee; K. Banicz; A. Barczyk; R. Barillère; L. Barone; P. Bartalini; A. Baschirotto; M. Basile; R. Battiston; A. Bay; F. Becattini; U. Becker; F. Behner; J. Berdugo; P. Berges; B. Bertucci; B. Bertucci; S. Bhattacharya; M. Biasini; A. Biland; G. M. Bilei; J. J. Blaising; S. C. Blyth; Gerjan J Bobbink; R K Böck; A. Böhm; L. Boldizsar; B. Borgia; D. Bourilkov; Maurice Bourquin; D. Boutigny; S. Braccini; J. G. Branson; V. Brigljevic; I. C. Brock; A. Buffini; J. D. Burger; W. J. Burger; X. D. Cai; M. Campanelli; M. Campanelli; G. Cara Romeo; G. Cara Romeo; A. M. Cartacci; J. Casaus; G. Castellini; F. Cavallari; N. Cavallo; C. Cecchi; M Cerrada-Canales; F. Cesaroni; M Chamizo-Llatas; Y. H. Chang; U. K. Chaturvedi; M. Chemarin; A. Chen; G. Chen; H. F. Chen; H. S. Chen; M. Chen; G. Chiefari; C. Y. Chien; Luisa Cifarelli; F. Cindolo; C. Civinini; I. Clare; I. Clare; G. Coignet; A. P. Colijn; N. Colino; S. Costantini; F. Cotorobai; B. de la Cruz; Akos Csilling; T. S. Dai; R. D'Alessandro; R. de Asmundis; A. Degré; K. Deiters; P. Denes; F. DeNotaristefani; M. Diemoz; D N Van Dierendonck; F. Di Lodovico; C. Dionisi; Michael Dittmar; A. Dominguez; A. Dominguez; M. T. Dova; E. Drago; D. Duchesneau; P. Duinker; I. Duran; S. Easo; H. El Mamouni; A. Engler; F. J. Eppling; F. C. Erné; Pierre Extermann; M. Fabre; R. Faccini; M. A. Falagan; S. Falciano; A. Favara; J. Fay; O. Fedin; Marta Felcini; T. Ferguson; F. Ferroni; H S Fesefeldt; E. Fiandrini; J. H. Field; Frank Filthaut; P. H. Fisher; I. Fisk; G. Forconi; L. Fredj; Klaus Freudenreich; C. Furetta; Yu. Galaktionov; S. N. Ganguli; P. Garcia-Abia; M. Gataullin; S. S. Gau; S. Gentile; J. Gerald; N. Gheordanescu; S. Giagu; S. Goldfarb; J. Goldstein; Z. F. Gong; Andreas Gougas; Giorgio Gratta; M. W. Gruenewald; R. van Gulik; V. K. Gupta; A. Gurtu; L. J. Gutay; D. Haas; B. Hartmann; A. Hasan; D. Hatzifotiadou; T. Hebbeker; A. Hervé; P. Hidas; J. Hirschfelder; W. C. van Hoek; H. Hofer; H. Hoorani; S. R. Hou; G. Hu; I. Iashvili; B. N. Jin; L. W. Jones; P. de Jong; I. Josa-Mutuberria; A. Kasser; R. A. Khan; D. Kamrad; J. S. Kapustinsky; Yu Karyotakis; M. Kaur; M. N. Kienzle-Focacci; D. Kim; J. K. Kim; S. C. Kim; W. W. Kinnison; A. Kirkby; D. Kirkby; Jasper Kirkby; D. Kiss; W. Kittel; A. Klimentov; A. Klimentov; A. Kopp; I. Korolko; V F Koutsenko; R. W. Kraemer; A. Kunin; P E Lacentre; P. Ladron de Guevara; G. Landi; C. Lapoint; K M Lassila-Perini; P. Laurikainen; A. Lavorato; M. Lebeau; A. Lebedev; P. Lebrun; P. Lecomte; P. Lecomte; P. Le Coultre; H. J. Lee; C. Leggett; J. M. Le Goff; R. Leiste; E. Leonardi; P. Levtchenko; Li Chuan; C. H. Lin; W. T. Lin; Frank L Linde; Z. A. Liu; W. Lohmann; E. Longo; W. Lu; Y. S. Lu; K. Lübelsmeyer; C. Luci; D. Luckey; L. Luminari; W. Lustermann; W. G. Ma; M. Maity; G. Majumder; L. Malgeri; A. Malinin; C. Maña; D J J Mangeol; P A Marchesini; G. Marian; A. Marin; J. P. Martin; F. Marzano; G. G. G. Massaro; K. Mazumdar; S. Mele; L. Merola; M. Meschini; W. J. Metzger; M. von der Mey; Y. Mi; D. Migani; A. Mihul; A. J. W. van Mil; H. Milcent; G. Mirabelli; J. Mnich; P. Molnar; B. Monteleoni; R. Moore; T. Moulik; R. Mount; G. S. Muanza; F. Muheim; A. J. M. Muijs; S. Nahn; M. Napolitano; F. Nessi-Tedaldi; H. Newman; T. Niessen; A. Nippe; A. Nisati; H. Nowak; Yu D Oh; G. Organtini; R. Ostonen; C. Palomares; D. Pandoulas; S. Paoletti; P. Paolucci; H. K. Park; I. H. Park; G. Pascale; G. Passaleva; S. Patricelli; T. Paul; M. Pauluzzi; C. Paus; Felicitas Pauss; D. Peach; M. Pedace; Y. J. Pei; S. Pensotti; D. Perret-Gallix; B. Petersen; S. Petrak; A. Pevsner; D. Piccolo; M. Pieri; P. A. Piroué; E. Pistolesi; V. Plyaskin; M. Pohl; V Pozhidaev; H. Postema; J. Pothier; N. Produit; D. Prokofiev; J. Quartieri; G. Rahal-Callot; N. Raja; P. G. Rancoita; M. Rattaggi; G. Raven; P. Razis; D. Ren; M. Rescigno; S. Reucroft; T. van Rhee; S. Riemann; K. Riles; O. Rind; A. Robohm; J. Rodin; B. P. Roe; L. Romero; S. Rosier-Lees; Ph. Rosselet; S. Roth; J. A. Rubio; D. Ruschmeier; H. Rykaczewski; S. Sakar; J. Salicio; E. Sanchez; M. P. Sanders; M. E. Sarakinos; G. Sauvage; C. Schäfer; V. Schegelsky; S. Schmidt-Kaerst; D. Schmitz; M. Schneegans; N. Scholz; H. Schopper; D. J. Schotanus; D. J. Schotanus; G. Schwering; C. Sciacca; D. Sciarrino; L. Servoli; S. Shevchenko; N. Shivarov; V. Shoutko; J. Shukla; E. Shumilov; A. Shvorob; T. Siedenburg; D. Son; V. Soulimov; B. Smith; P. Spillantini; M. Steuer; D. P. Stickland; H. Stone; B. Stoyanov; A. Straessner; K. Sudhakar; G. Sultanov; L. Z. Sun; G. F. Susinno; H. Suter; J. D. Swain; X. W. Tang; L. Tauscher

    1998-01-01

    Four of the Michel parameters and the average tau-neutrino helicity have been measured by analysing tau decay spectra in 147 pb?1of data collected by the L3 detector. The decays ???e?????e, ??????????, ???????, ??????? and their charge conjugates were considered. The results: ?=0.762±0.035, ?=0.27±0.14, ?=0.70±0.16, ??=0.70±0.11 and ?h=?1.032±0.031 are consistent with a V?A structure for the weak charged current and lepton

  8. Measurement of Cabibbo-Suppressed Tau Lepton Decays and the Determination of |Vus|

    SciTech Connect

    Schenk, Stefan; /SLAC

    2008-12-16

    This work presents simultaneous branching fraction measurements of the decay modes {tau}{sup -} {yields} K{sup -} n{pi}{sup 0}{nu}{sub {tau}} with n = 0,1,2,3 and {tau}{sup -} {yields} {pi}{sup -} n{pi}{sup 0}{nu}{sub {tau}} with n = 3,4. The analysis is based on a data sample of 427 x 10{sup 6} {tau}{sup +}{tau}{sup -} pairs recorded with the BABAR detector, which corresponds to an integrated luminosity of 464.4 fb{sup -1}. The measured values are {Beta}({tau}{sup -} {yields} K{sup -}{nu}{sub {tau}}) = (6.57 {+-} 0.03 {+-} 0.11) x 10{sup -3}, {Beta}({tau}{sup -} {yields} K{sup -}{pi}{sup 0}{nu}{sub {tau}}) = (4.61 {+-} 0.03 {+-} 0.11) x 10{sup -3}, {Beta}({tau}{sup -} {yields} K{sup -} {pi}{sup 0}{pi}{sup 0}{nu}{sub {tau}}) = (5.05 {+-} 0.17 {+-} 0.44) x 10{sup -4}, {Beta}({tau}{sup -} {yields} K{sup -}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{nu}{sub {tau}}) = (1.31 {+-} 0.43 {+-} 0.40) x 10{sup -4}, {Beta}({tau}{sup 0} {yields} {pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{nu}{sub {tau}}) = (1.263 {+-} 0.008 {+-} 0.078) x 10{sup -2} and {Beta}({tau}{sup 0} {yields} {pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{nu}{sub {tau}}) = (9.6 {+-} 0.5 {+-} 1.2) x 10{sup -4}, where the uncertainties are statistical and systematic, respectively. All measurements are compatible with the current world averages whereas the uncertainties are significantly smaller by a factor of up to five. The determination of {Beta}({tau}{sup 0} {yields} {pi}{sup -}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}{nu}{sub {tau}}) is the first measurement of this branching fraction. The measured branching fractions are combined with the current world averages. Using the new averages, an updated determination of |V{sub us}| from hadronic {tau} decays yields |V{sub us}| = 0.2146 {+-} 0.0025, which improves previous measurements by 19%. Its uncertainty is comparable to the one of the current world average from semileptonic kaon decays.

  9. Leptonic decays of tau/sup -/ lepton: Finite. nu. /sub tau/ mass and effects of mass mixing

    SciTech Connect

    Sharma, R.R.L.; Sharma, N.K.

    1984-04-01

    A reexamination of the leptonic decays of the tau/sup -/ lepton with the inclusion of mass mixing of a hierarchical type provides mass limits as 389.98 +- 135.36 and 329.34 +- 172.07 MeV from the electronic and muonic decays, respectively. Slightly different values are obtained for Kobayashi-Maskawa mixing, but with no mass mixing, the limits are substantially higher. The decay probabilities are sensitive to mass mixing, whereas Michel spectra remain practically unaffected.

  10. Kaon content of three-prong decays of the tau lepton

    SciTech Connect

    Eastman, J.J.

    1990-12-01

    We present a series of measurements involving the production of charged kaons in three-prong hadronic decays of the {tau} lepton. The data sample was obtained with the TPC/Two-Gamma detector facility at PEP. We set a limit on the branching fraction BR({tau}{sup {minus}} {yields} {nu}{sub {tau}}K{sup {minus}}K{sup 0}) < 0.26% at the 95% confidence level. The process {tau}{sup {minus}} {yields} {nu}{sub {tau}}K{sup {minus}}K{sup 0} is related via SU(3) to the second-class current decay {tau}{sup {minus}} {yields} {nu}{sub {tau}}{pi}{sup {minus}}{eta}. We also present new measurements of the three-prong branching fractions BR({tau}{sup {minus}} {yields} {nu}{sub {tau}}K{sup {minus}}{pi}{sup +}{pi}{sup {minus}} + neutrals) = 0.70 (+0.20/{minus}0.17)% and BR({tau}{sup {minus}} {yields} {nu}{sub {tau}}K{sup {minus}}K{sup +}{pi}{sup {minus}} + neutrals) = 0.16 (+0.10/{minus}0.07)%. 68 refs., 29 figs., 15 tabs.

  11. Search for Rare Multi-Pion Decays of the Tau Lepton Using the BABAR Detector

    SciTech Connect

    Ter-Antonyan, Ruben

    2007-09-18

    A search for the decay of the {tau} lepton to rare multi-pion final states is performed using the BABAR detector at the PEP-II asymmetric-energy e+e- collider. The analysis uses 232 fb-1 of data at center-of-mass energies on or near the {Upsilon}(4S) resonance. In the search for the {tau}- {yields} 3{pi}-2{pi}+2{pi}{sup 0}{nu}{sub {tau}} decay, we observe 10 events with an expected background of 6.5{sup +2.0}{sub -1.4} events. In the absence of a signal, we calculate the decay branching ratio upper limit {beta}({tau}- {yields} 3{pi}-2{pi}+2{pi}{sup 0}{nu}{sub {tau}}) < 3.4 x 10{sup -6} at the 90% confidence level. This is more than a factor of 30 improvement over the previously established limit. In addition, we search for the exclusive decay mode {tau}- {yields} 2{omega}{pi}-{nu}{sub {tau}} with the further decay of {omega} {yields} {pi}-{pi}+{pi}{sup 0}. We observe 1 event, expecting 0.4{sup +1.0}{sub -0.4} background events, and calculate the upper limit {beta}{tau}-{yields} 2{omega}{pi}-{nu}{sub {tau}} < 5.4 x 10{sup -7} at the 90% confidence level. This is the first upper limit for this mode.

  12. Search for doubly charged Higgs bosons with lepton-flavour-violating decays involving tau leptons

    SciTech Connect

    Aaltonen, T.

    2007-12-01

    The authors search for pair production of doubly charged Higgs particles (H{sup {+-}{+-}}) followed by decays into electron-tau (e{tau}) and muon-tau ({mu}{tau}) pairs using a data set corresponding to an integrated luminosity of 350 pb{sup -1} collected from {bar p}p collisions at {radical}s = 1.96 TeV by the CDF II experiment. They search separately for cases where three or four final-state leptons are detected, and then combine the results into limits for each exclusive flavor decay mode of the H{sup {+-}{+-}}. Assuming 100% branching ratios of the H{sup {+-}{+-}} to left-handed e{tau} ({mu}{tau}) pairs, they set an H{sup {+-}{+-}} lower mass limit of 114 (112) GeV/c{sup 2} at the 95% confidence level (C.L.).

  13. Measurement of the spectral functions of vector current hadronic tau decays

    Microsoft Academic Search

    Damir Buskulic; D. Decamp; P. Ghez; C. Goy; J P Lees; A Lucotte; M N Minard; J Y Nief; B Pietrzyk; M P Casado; M Chmeissani; P Comas; J M Crespo; M C Delfino; E Fernández; M Fernández-Bosman; L Garrido; A Juste; M Martínez; R Miquel; L M Mir; S Orteu; C Padilla; I C Park; A Pascual; J A Perlas; I Riu; F Sánchez; F Teubert; A Colaleo; D Creanza; M De Palma; G Gelao; Giuseppe Iaselli; G Maggi; M Maggi; N Marinelli; S Nuzzo; A Ranieri; G Raso; F Ruggieri; G Selvaggi; L Silvestris; P Tempesta; A Tricomi; G Zito; X Huang; J Lin; Q Ouyang; T Wang; Y Xie; R Xu; S Xue; J Zhang; L Zhang; W Zhao; D Abbaneo; R Alemany; U Becker; A O Bazarko; P G Bright-Thomas; M Cattaneo; F Cerutti; H Drevermann; Roger W Forty; M Frank; R Hagelberg; J Harvey; P Janot; B Jost; E Kneringer; J Knobloch; Ivan Lehraus; G Lutters; P Mato; Adolf G Minten; L Moneta; A Pacheco; J F Pusztaszeri; F Ranjard; P E Rensing; G Rizzo; Luigi Rolandi; W D Schlatter; M Schmitt; O Schneider; W Tejessy; I R Tomalin; H W Wachsmuth; A Wagner; Ziad J Ajaltouni; A Barrès; C Boyer; A Falvard; C Ferdi; P Gay; C Guicheney; P Henrard; J Jousset; B Michel; S Monteil; J C Montret; D Pallin; P Perret; F Podlyski; J Proriol; P Rosnet; J M Rossignol; Tom Fearnley; J B Hansen; J D Hansen; P H Hansen; B S Nilsson; B Rensch; A Wäänänen; G Daskalakis; A Kyriakis; C Markou; Errietta Simopoulou; I Siotis; Anna Vayaki; A Blondel; G R Bonneaud; J C Brient; P Bourdon; A Rougé; M Rumpf; Andrea Valassi; M Verderi; H L Videau; D J Candlin; M I Parsons; E Focardi; G Parrini; K Zachariadou; M Corden; C H Georgiopoulos; D E Jaffe; A Antonelli; G Bencivenni; G Bologna; F Bossi; P Campana; G Capon; David William Casper; V Chiarella; G Felici; P Laurelli; G Mannocchi; F Murtas; G P Murtas; L Passalacqua; M Pepé-Altarelli; L Curtis; S J Dorris; A W Halley; I G Knowles; J G Lynch; V O'Shea; C Raine; J M Scarr; K Smith; P Teixeira-Dias; A S Thompson; E Thomson; F Thomson; R M Turnbull; C Geweniger; G Graefe; P Hanke; G Hansper; V Hepp; E E Kluge; A Putzer; M Schmidt; J Sommer; K Tittel; S Werner; M Wunsch; R Beuselinck; David M Binnie; W Cameron; Peter J Dornan; M Girone; S M Goodsir; E B Martin; A Moutoussi; J Nash; J K Sedgbeer; A M Stacey; M D Williams; G Dissertori; P Girtler; D Kuhn; G Rudolph; A P Betteridge; C K Bowdery; P Colrain; G Crawford; A J Finch; F Foster; G Hughes; Terence Sloan; M I Williams; A Galla; I Giehl; A M Greene; C Hoffmann; K Jakobs; K Kleinknecht; G Quast; B Renk; E Rohne; H G Sander; P Van Gemmeren; C Zeitnitz; Jean-Jacques Aubert; C Benchouk; A Bonissent; G Bujosa; D Calvet; J Carr; P Coyle; C A Diaconu; F Etienne; N P Konstantinidis; O Leroy; F Motsch; P Payre; D Rousseau; M Talby; A Sadouki; M Thulasidas; K Trabelsi; M Aleppo; F Ragusa; R Berlich; Walter Blum; V Büscher; H Dietl; Friedrich Dydak; G Ganis; C Gotzhein; H Kroha; G Lütjens; Gerhard Lutz; W Männer; H G Moser; R H Richter; A Rosado-Schlosser; S Schael; Ronald Settles; H C J Seywerd; R Saint-Denis; H Stenzel; W Wiedenmann; G Wolf; J Boucrot; O Callot; S Chen; Y Choi; A Cordier; M Davier; L Duflot; J F Grivaz; P Heusse; A Höcker; A Jacholkowska; M Jacquet; D W Kim; F R Le Diberder; J Lefrançois; A M Lutz; I A Nikolic; M H Schune; S Simion; E Tournefier; J J Veillet; I Videau; D Zerwas; P Azzurri; G Bagliesi; G Batignani; S Bettarini; C Bozzi; G Calderini; M Carpinelli; M A Ciocci; V Ciulli; R Dell'Orso; R Fantechi; I Ferrante; L Foà; F Forti; A Giassi; M A Giorgi; A Gregorio; F Ligabue; A Lusiani; P S Marrocchesi; A Messineo; Fabrizio Palla; G Sanguinetti; A Sciabà; P Spagnolo; Jack Steinberger; Roberto Tenchini; G Tonelli; C Vannini; A Venturi; P G Verdini; G A Blair; L M Bryant; J T Chambers; Y Gao; M G Green; T Medcalf; P Perrodo; J A Strong; J H Von Wimmersperg-Töller; David R Botterill; R W Clifft; T R Edgecock; S Haywood; P Maley; P R Norton; J C Thompson; A E Wright; B Bloch-Devaux; P Colas; S Emery; Witold Kozanecki; E Lançon; M C Lemaire; E Locci; P Pérez; J Rander; J F Renardy; A Roussarie; J P Schuller; J Schwindling; A Trabelsi; B Vallage; S N Black; J H Dann; R P Johnson; H Y Kim; A M Litke; M A McNeil; G Taylor; C N Booth; R Boswell; C A J Brew; S L Cartwright; F Combley; M S Kelly; M H Lehto; W M Newton; J Reeve; L F Thompson; A Böhrer; S Brandt; G D Cowan; Claus Grupen; P Saraiva; L Smolik; F Stephan; M Apollonio; L Bosisio; R Della Marina; G Giannini; B Gobbo; G Musolino; J E Rothberg; S R Wasserbaech; S R Armstrong; E Charles; P Elmer; D P S Ferguson; S González; T C Greening; O J Hayes; H Hu; S Jin; P A McNamara; J M Nachtman; J Nielsen; W Orejudos; Y B Pan; Y Saadi; I J Scott; J Walsh; Wu Sau Lan; X Wu; J M Yamartino; G Zobernig

    1997-01-01

    A measurement of the spectral functions of non-strange $\\\\tau$ vector current final states is presented, using 124 358 $\\\\tau$ pairs recorded by the ALEPH detector at LEP during the years 1991 to 1994. The spectral functions of the dominant two- and four-pion $\\\\tau$ decay channels are compared to published results of $e^+e^-$ annihilation experiments via isospin rotation. A combined fit

  14. Software for physics of tau lepton decay in LHC experiments

    E-print Network

    Tomasz Przedzinski

    2010-09-20

    Software development in high energy physics experiments offers unique experience with rapidly changing environment and variety of different standards and frameworks that software must be adapted to. As such, regular methods of software development are hard to use as they do not take into account how greatly some of these changes influence the whole structure. The following thesis summarizes development of TAUOLA C++ Interface introducing tau decays to new event record standard. Documentation of the program is already published. That is why it is not recalled here again. We focus on the development cycle and methodology used in the project, starting from the definition of the expectations through planning and designing the abstract model and concluding with the implementation. In the last part of the paper we present installation of the software within different experiments surrounding Large Hadron Collider and the problems that emerged during this process.

  15. High-Statistics Study of the tau^- -> pi^- pi^0 nu_tau Decay

    E-print Network

    M. Fujikawa; H. Hayashii; S. Eidelman; for the Belle Collaboration

    2008-10-29

    We report a high-statistics measurement of the branching fraction for tau^- --> pi^- pi^0 nu_tau and the invariant mass spectrum of the produced pi^- pi^0 system using 72.2 fb^-1 of data recorded with the Belle detector at the KEKB asymmetric-energy e^+ e^- collider. The branching fraction obtained is (25.24 +/- 0.01 +/- 0.39)%, where the first error is statistical and the second is systematic. The unfolded pi^- pi^0 mass spectrum is used to determine resonance parameters for the rho(770), rho'(1450), and rho"(1700) mesons. We also use this spectrum to estimate the hadronic (2pi) contribution to the anomalous magnetic moment of the muon (a_{mu}^{pipi}). Our result for a_{mu}^{pipi} integrated over the mass range sqrt{s} = 2m_{pi} - 1.8 GeV/c^2 is a_{mu}^{pipi} = (523.5 +/- 1.5 (exp) +/- 2.6 (Br) +/- 2.5 (isospin))x 10^{-10}, where the first error is due to the experimental uncertainties, the second is due to the uncertainties in the branching fractions and the third is due to the uncertainties in the isospin-violating corrections.

  16. Review of new experimental upper limits on forbidden decay modes of the tau lepton

    SciTech Connect

    Hayes, K.G.; Perl, M.L.

    1981-02-01

    This paper presents a review of experimental upper limits on the branching fractions for various forbidden decay modes of the tau lepton. These are modes which cannot occur in the conventional model in which the tau and its associated neutrino have a unique, conserved lepton number. The limits are based on data acquired by the Mark II Detector Collaboration at SPEAR.

  17. Upper Bound on the Decay tau-->mugamma from the Belle Detector

    Microsoft Academic Search

    K. Abe; T. Abe; I. Adachi; Byoung Sup Ahn; H. Aihara; K. Akai; M. Akatsu; M. Akemoto; Y. Asano; T. Aso; V. Aulchenko; T. Aushev; A. M. Bakich; Y. Ban; S. Banerjee; A. Bay; I. Bedny; I. Bizjak; A. Bondar; A. Bozek; M. Bracko; T. E. Browder; Y. Chao; K.-F. Chen; B. G. Cheon; R. Chistov; S.-K. Choi; Y. Choi; A. Chuvikov; M. Danilov; L. Y. Dong; A. Drutskoy; S. Eidelman; V. Eiges; Y. Enari; J. Flanagan; C. Fukunaga; K. Furukawa; N. Gabyshev; A. Garmash; T. Gershon; R. Guo; J. Haba; C. Hagner; F. Handa; H. Hayashii; M. Hazumi; T. Hokuue; Y. Hoshi; W.-S. Hou; H.-C. Huang; T. Iijima; H. Ikeda; K. Inami; A. Ishikawa; R. Itoh; H. Iwasaki; M. Iwasaki; Y. Iwasaki; J. H. Kang; J. S. Kang; N. Katayama; H. Kawai; T. Kawasaki; H. Kichimi; E. Kikutani; H. J. Kim; J. H. Kim; S. K. Kim; K. Kinoshita; P. Koppenburg; S. Korpar; P. Krokovny; R. Kulasiri; A. Kuzmin; Y.-J. Kwon; S. H. Lee; T. Lesiak; J. Li; A. Limosani; S.-W. Lin; D. Liventsev; F. Mandl; T. Matsumoto; A. Matyja; S. Michizono; T. Mimashi; W. Mitaroff; K. Miyabayashi; H. Miyata; D. Mohapatra; T. Mori; T. Nagamine; Y. Nagasaka; T. T. Nakamura; E. Nakano; M. Nakao; H. Nakazawa; Z. Natkaniec; S. Nishida; O. Nitoh; S. Ogawa; Y. Ogawa; K. Ohmi; Y. Ohnishi; T. Ohshima; N. Ohuchi; T. Okabe; S. Okuno; W. Ostrowicz; H. Ozaki; H. Palka; C. W. Park; N. Parslow; L. E. Piilonen; N. Root; H. Sagawa; S. Saitoh; Y. Sakai; M. Satapathy; A. Satpathy; O. Schneider; J. Schümann; A. J. Schwartz; S. Semenov; K. Senyo; R. Seuster; M. E. Sevior; H. Shibuya; T. Shidara; B. Shwartz; V. Sidorov; J. B. Singh; N. Soni; S. Stanic; M. Staric; A. Sugi; K. Sumisawa; T. Sumiyoshi; S. Suzuki; F. Takasaki; K. Tamai; N. Tamura; M. Tanaka; M. Tawada; G. N. Taylor; Y. Teramoto; T. Tomura; T. Tsuboyama; T. Tsukamoto; S. Uehara; K. Ueno; S. Uno; G. Varner; C. C. Wang; J. G. Wang; Y. Watanabe; E. Won; B. D. Yabsley; Y. Yamada; A. Yamaguchi; Y. Yamashita; M. Yamauchi; H. Yanai; Heyoung Yang; M. Yoshida; Y. Yusa; Z. P. Zhang; Y. Zheng; V. Zhilich; D. Zontar

    2004-01-01

    We have performed a search for the lepton-flavor-violating decay tau-->mugamma using a data sample of 86.3 fb-1 accumulated by the Belle detector at KEK. No evidence for a signal is seen, and we set an upper limit for the branching fraction of B(tau-->mugamma)<3.1×10-7 at the 90% confidence level.

  18. Limit on tau neutrino mass

    SciTech Connect

    Abachi, S.; Akerlof, C.; Baringer, P.; Beltrami, I.; Blockus, D.; Bonvicini, G.; Brabson, B.; Bylsma, B.G.; Chapman, J.; Cork, B.

    1986-01-01

    Using the complete data sample of 300 pb/sup -1/ collected by the HRS spectrometer in e/sup +/e/sup -/ collisions at 29 GeV, mass limit for the tau neutrino is set. The end point of the hadronic mass spectrum is determined in the decays tau ..-->.. 5..pi../sup + -/nu/sub tau/ and tau ..-->.. 5..pi../sup + -/..pi../sup 0/nu/sub tau/. At 95% confidence level, an upper limit of M/sub nu/sub tau// < 76 MeV/c/sup 2/, is found. 8 refs., 4 figs.

  19. Tau hadronic branching ratios

    Microsoft Academic Search

    D. Casper; D. Decamp; P. Ghez; C. Goy; A. Lucotte; N. Minard; P. Odier; B. Pietrzyk; F. Ariztizabal; M. Chmeissani; I. Efthymiopoulos; E. Fernandez; M. Fernandez-Bosman; V. Gaitan; M. Martinez; S. Orteu; A. Pacheco; C. Padilla; F. Palla; A. Pascual; F. Sanchez; F. Teubert; A. Colaleo; D. Creanza; M. de Palma; A. Farilla; G. Gelao; M. Girone; G. Iaselli; G. Maggi; M. Maggi; N. Marinelli; S. Natali; S. Nuzzo; A. Ranieri; G. Raso; F. Romano; F. Ruggieri; G. Selvaggi; L. Silvestris; P. Tempesta; G. Zito; X. Huang; J. Lin; Q. Ouyang; T. Wang; Y. Xie; R. Xu; S. Xue; J. Zhang; L. Zhang; W. Zhao; G. Bonvicini; M. Cattaneo; P. Comas; P. Coyle; H. Drevermann; A. Engelhardt; M. Frank; R. Hagelberg; J. Harvey; R. Jacobsen; B. Jost; E. Kneringer; J. Knobloch; I. Lehraus; C. Markou; P. Mato; A. Minten; R. Miquel; T. Oest; P. Palazzi; F. Ranjard; P. Rensing; L. Rolandi; D. Schlatter; M. Schmelling; O. Schneider; W. Tejessy; A. Venturi; H. Wachsmuth; W. Wiedenmann; T. Wildish; W. Witzeling; J. Wotschack; Z. Ajaltouni; M. Bardadin-Otwinowska; A. Barres; C. Boyer; A. Falvard; P. Gay; C. Guicheney; P. Henrard; J. Jousset; B. Michel; S. Monteil; D. Pallin; P. Perret; F. Podlyski; J. Proriol; F. Saadi

    1996-01-01

    From 64492 selected $\\\\tau$-pair events, produced at the $Z^0$ resonance, the measurement of the tau decays into hadrons from a global analysis using 1991, 1992 and 1993 ALEPH data is presented. Special emphasis is given to the reconstruction of photons and$\\\\pi^0$ 's, and the removal of fake photons. A detailed study of the systematics entering the$\\\\pi^0$ reconstruction is also given.

  20. Search for neutral MSSM Higgs bosons decaying to a pair of tau leptons in pp collisions

    E-print Network

    CMS Collaboration

    A search for neutral Higgs bosons in the minimal supersymmetric extension of the standard model (MSSM) decaying to tau-lepton pairs in pp collisions is performed, using events recorded by the CMS experiment at the LHC. The ...

  1. Limits on tau lepton-flavor violating decays into three charged leptons

    E-print Network

    Cowan, Ray Franklin

    A search for the neutrinoless, lepton-flavor violating decay of the ? [tau] lepton into three charged leptons has been performed using an integrated luminosity of 468??fb-1 [fb superscript -1] collected with the BABAR ...

  2. Determination of the Higgs CP-mixing angle in the tau decay channels

    E-print Network

    Stefan Berge; Werner Bernreuther; Sebastian Kirchner

    2014-10-23

    The measurement of possible Higgs sector CP-violation in the tau decay channels at the LHC is investigated. A CP-violating effect would manifest itself in these decay modes in characteristic spin-spin correlations of the tau lepton pairs which can be accessed using the momenta and impact parameters of the charged tau decay particles. We examine a CP-sensitive observable for a 125 GeV Higgs boson resonance in the gluon fusion channel at the LHC. Furthermore, we consider the distribution of this observable for the irreducible Drell-Yan background. By splitting these events into two categories we obtain two different distributions which can be used for calibration purposes. Finally, we estimate the achievable precision of the scalar-pseudo-scalar mixing angle of the tau decay channel for Run II and the high luminosity run of the LHC.

  3. Review of Standard Tau Decays From the B-Factory Experiments

    SciTech Connect

    Salvatore, F.; /Royal Holloway, U. of London

    2011-11-15

    B-factories have been successfully operating for more than 8 years, providing an unprecedented data sample of e{sup +}e{sup 0} {yields} hadrons events. The BABAR and Belle experiments have in fact already collected over 550 fb{sup -1} and 800 fb{sup -1} respectively at the {Upsilon}(4s) center-of-mass (CM) energy. At this energy, the cross-section for tau production is of the same order of the cross-section for b production: {sigma}(b{bar b}) {approx} 1.1 nb {approx} {sigma}({tau}{sup +}{tau}{sup -}) {approx} 0.9 nb. For this reason, B-factories can now be considered also Tau-factories. A review of the most recent results on standard tau decays from the BABAR and Belle experiments is presented in this article.

  4. Search for anomalous couplings in the decay of polarized Z bosons to tau lepton pairs

    SciTech Connect

    Torrence, E.C.

    1997-06-01

    Using a sample of 4,500 polarized Z decays to {tau} lepton pairs accumulated with the SLD detector at the SLAC Linear Collider (SLC) in 1993-95, a search has been made for anomalous couplings in the neutral current reaction e{sup +}e{sup {minus}}{yields}{tau}{sup +}{tau}{sup {minus}}. A measurement of the CP violating Weak Electric Dipole Moment (WEDM) and the CP conserving Weak Magnetic Dipole Moment (WMDM) of the {tau} lepton has been performed by considering the transverse spin polarization of {tau} leptons produced at the Z pole. Using a maximum likelihood technique, the observed {tau} decay spectra in the e, {mu}, {pi}, and {rho} decay channels are used to infer the net transverse polarization of the underlying tau leptons, and a fit for the anomalous dipole moments is performed. No evidence for these dipole movements is observed, and limits are placed on both the real and imaginary parts of the WEDM and WMDM.

  5. Measurement of the inclusive K/sub S//sup 0/ branching fraction in tau decay

    SciTech Connect

    Tschirhart, R.; Abachi, S.; Akerlof, C.; Baringer, P.; Blockus, D.; Brabson, B.; Brom, J.M.; Bylsma, B.G.; Chapman, J.; Cork, B.

    1987-01-01

    A data sample corresponding to an integrated luminosity of 300 pb/sup -1/ of e/sup +/e/sup -/ annihilations at 29 GeV was used to measure the inclusive branching fraction tau/sup -/ ..-->.. K/sub S//sup 0/X/sup -/nu/sub tau/. The experiment was performed using the High Resolution Spectrometer at the PEP storage ring. The measured branching fraction is (0.64 +- 0.15)%. The data are consistent with all K/sub S//sup 0/ coming from the Cabibbo-suppressed decay tau ..-->.. K*/sup -/(890)nu/sub tau/ leading to a branching ratio of (1.9 +- 0.28 +- 0.25)% for this channel. The inclusive sample was used to set 90% CL limits on the branching fractions of tau/sup -/ ..-->.. rho/sup -/(1600)nu/sub tau/ and tau/sup -/ ..-->.. K*/sup -/(1430)nu/sub tau/ of 8.5%, and 0.3% respectively. 18 refs., 3 figs.

  6. A measurement of the tau lepton lifetime

    Microsoft Academic Search

    M. Battle; J. Ernst; H. Kroha; S. Roberts; K. Sparks; E. H. Thorndike; C.-H. Wang; R. Stroynowski; M. Artuso; M. Goldberg; N. Horwitz; R. Kennett; G. C. Moneti; F. Muheim; S. Playfer; Y. Rozen; P. Rubin; T. Skwarnicki; S. Stone; M. Thulasidas; W.-M. Yao; G. Zhu; A. V. Bernes; J. Bartelt; S. E. Csorna; Z. Egyed; V. Jain; T. Letson; M. D. Mestayer; P. Sheldon; D. S. Akerib; B. Barish; M. Chadha; D. F. Cowen; G. Eigen; J. S. Miller; J. Urheim; A. J. Weinstein; D. Acosta; G. Masek; B. Ong; H. Paar; M. Sivertz; A. Bean; J. Gronberg; R. Kutschke; S. Menary; R. J. Morrison; H. Nelson; J. Richman; H. Tajima; D. Schmidt; D. Sperka; M. Witherell; M. Procario; M. Daoudi; W. T. Ford; D. R. Johnson; K. Lingel; M. Lohner; P. Rankin; J. G. Smith; J. P. Alexander; C. Bebek; K. Berkelman; D. Besson; T. E. Browder; D. G. Cassel; E. Cheu; D. M. Coffman; P. S. Drell; R. Ehrlich; R. S. Galik; M. Garcia-Sciveres; B. Geiser; B. Gittelman; S. W. Gray; A. M. Halling; D. L. Hartill; B. K. Heltsley; K. Honscheid; C. Jones; J. Kandaswamy; N. Katayama; P. C. Kim; D. L. Kreinick; J. D. Lewis; G. S. Ludwig; J. Masui; J. Mevissen; N. B. Mistry; S. Nandi; C. R. Ng; E. Nordberg; C. O'Grady; J. R. Patterson; D. Peterson; M. Pisharody; D. Riley; M. Sapper; M. Selen; A. Silverman; H. Worden; M. Worris; F. Würthwein; P. Avery; A. Freyberger; J. Rodriguez; R. Stephens; J. Yelton; D. Cinabro; S. Henderson; K. Kinoshita; T. Liu; F. M. Pipkin; M. Saulnier; R. Wilson; J. Wolinski; D. Xiao; H. Yamamoto; A. J. Sadoff; R. Ammar; S. Ball; P. Baringer; D. Coppage; N. Copty; R. Davis; P. Haas; N. Hancock; M. Kelly; N. Kwak; H. Lam; S. Ro; Y. Kubota; M. Lattery; J. K. Nelson; D. Perticone; R. Poling; S. Schrenk; R. Wang; M. S. Alam; I. J. Kim; W. C. Li; B. Nemati; J. J. O'Neill; V. Romero; H. Severini; C. R. Sun; P.-N. Wang; M. M. Zoeller; G. Crawford; R. Fulton; K. K. Gan; T. Jensen; H. Kagan; R. Kass; J. Lee; R. Malchow; F. Morrow; M. Sung; C. White; J. Whitmore; P. Wilson; F. Butler; X. Fu; G. Kalbfleisch; M. Lambrecht; P. Skubic; J. Snow; P.-L. Wang; D. Bortoletto; D. N. Brown; J. Dominick; R. L. McIlwain; T. Miao; D. H. Miller; M. Modesitt; S. F. Schaffner; E. I. Shibata; I. P. J. Shipsey

    1992-01-01

    Using tau+tau- pairs in which one tau decays to leptons and the other decays to 3 charged particles we present a high statistics measurement of the tau lepton lifetime. The data used in this analysis were collected with the CLEO detector at CESR and consist of an integrated luminosity of 429 pb-1 taken at, above, and below the Upsilon (4S).

  7. Search for charged Higgs boson decays of the top quark using hadronic {tau} decays

    SciTech Connect

    Abe, F.; Akimoto, H.; Akopian, A.; Albrow, M.G.; Amendolia, S.R.; Amidei, D.; Antos, J.; Anway-Wiese, C.; Aota, S.; Apollinari, G.; Asakawa, T.; Ashmanskas, W.; Atac, M.; Auchincloss, P.; Azfar, F.; Azzi-Bacchetta, P.; Bacchetta, N.; Badgett, W.; Bagdasarov, S.; Bailey, M.W.; Bao, J.; de Barbaro, P.; Barbaro-Galtieri, A.; Barnes, V.E.; Barnett, B.A.; Bauer, G.; Baumann, T.; Bedeschi, F.; Behrends, S.; Belforte, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Benlloch, J.; Bensinger, J.; Benton, D.; Beretvas, A.; Berge, J.P.; Berryhill, J.; Bertolucci, S.; Bhatti, A.; Biery, K.; Binkley, M.; Bisello, D.; Blair, R.E.; Blocker, C.; Bodek, A.; Bokhari, W.; Bolognesi, V.; Bortoletto, D.; Boudreau, J.; Breccia, L.; Bromberg, C.; Bruner, N.; Buckley-Geer, E.; Budd, H.S.; Burkett, K.; Busetto, G.; Byon-Wagner, A.; Byrum, K.L.; Cammerata, J.; Campagnari, C.; Campbell, M.; Caner, A.; Carithers, W.; Carlsmith, D.; Castro, A.; Cauz, D.; Cen, Y.; Cervelli, F.; Chao, H.Y.; Chapman, J.; Cheng, M.; Chiarelli, G.; Chikamatsu, T.; Chiou, C.N.; Christofek, L.; Cihangir, S.; Clark, A.G.; Cobal, M.; Contreras, M.; Conway, J.; Cooper, J.; Cordelli, M.; Couyumtzelis, C.; Crane, D.; Cronin-Hennessy, D.; Culbertson, R.; Cunningham, J.D.; Daniels, T.; DeJongh, F.; Delchamps, S.; DellAgnello, S.; DellOrso, M.; Demortier, L.; Denby, B.; Deninno, M.; Derwent, P.F.; Devlin, T.; Dickson, M.; Dittmann, J.R.; Donati, S.; Done, J.; Dorigo, T.; Dunn, A.; Eddy, N.; Einsweiler, K.; Elias, J.E.; Ely, R.; Engels, E. Jr.; Errede, D.; Errede, S.; Fan, Q.; Fiori, I.; Flaugher, B.; Foster, G.W.; Franklin, M.; Frautschi, M.; Freeman, J.; Friedman, J.; Frisch, H.; Fuess, T.A.; Fukui, Y.; Funaki, S.; Gagliardi, G.; Galeotti, S.; Gallinaro, M.; Garcia-Sciveres, M.; Garfinkel, A.F.; Gay, C.; Geer, S.; Gerdes, D.W.; Giannetti, P.; Giokaris, N.; Giromini, P.; Gladney, L.; Glenzinski, D.; Gold, M.; Gonzalez, J.; Gordon, A.; Goshaw, A.T.; Goulianos, K.; Grassmann, H.; Groer, L.; Grosso-Pilcher, C.

    1996-07-01

    We present the result of a search for charged Higgs boson decays of the top quark, produced in {ital p{bar p}} collisions at {radical}{ital s}=1.8 TeV. When the charged Higgs boson is heavy and decays to a {tau} lepton, which subsequently decays hadronically, the resulting events have a unique signature: large missing transverse energy and the low-charged-multiplicity {tau}. Data collected in 1992 and 1993 at the Collider Detector at Fermilab, corresponding to 18.7{plus_minus}0.7 pb{sup {minus}1}, exclude new regions of combined top quark and charged Higgs boson mass, in extensions to the standard model with two Higgs doublets. {copyright} {ital 1996 The American Physical Society.}

  8. Search for the Decay $\\tau^- \\rightarrow 3\\pi^- 2\\pi^+2\\pi^0 \

    SciTech Connect

    Aubert, B.

    2006-04-10

    A search for the decay of the {tau} lepton to five charged and two neutral pions is performed using data collected by the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} collider. The analysis uses 232 fb{sup -1} of data at center-of-mass energies on or near the {Upsilon}(4S) resonance. We observe 10 events with an expected background of 6.5{sub -1.4}{sup +2.0} events. In the absence of a signal, we set the limit on the branching ratio {Beta}({tau}{sup -} {yields} 3{pi}{sup -}2{pi}{sup +}2{pi}{sup 0}{nu}{sub {tau}}) < 3.4 x 10{sup -6} at the 90% confidence level. This is a significant improvement over the previously established limit. In addition, we search for the decay mode {tau}{sup -} {yields} 2{omega}{pi}{sup -}{nu}{sub {tau}}. We observe 1 event with an expected background of 0.4{sub -0.4}{sup +1.0} events and calculate the upper limit {Beta}({tau}{sup -} {yields} 2{omega}{pi}{sup -}{nu}{sub {tau}}) < 5.4 x 10{sup -7} at the 90% confidence level. This is the first upper limit for this mode.

  9. Search for Higgs decays to tau lepton pairs at the Tevatron

    E-print Network

    I. Kravchenko; for the CDF; D0 Collaborations

    2007-10-26

    We present a search for neutral supersymmetric Higgs bosons decaying to tau+tau- pairs produced in ppbar collisions at sqrt{s}=1.96 TeV. The data have been collected with the CDF II and D0 detectors at the Tevatron collider at Fermilab (1 fb^-1 of integrated luminosity per experiment). No significant excess above the standard model backgrounds is observed. We set exclusion limits on the Higgs production cross-section times the branching fraction of its decay to tau+tau- pairs for Higgs masses in the range from 90 to 250 GeV/c^2. We also set exclusion limits on MSSM parameters m_A and tan_beta in several benchmark scenarios.

  10. Structure functions in the decay tau-\\/+-->pi-\\/+pi0pi0nutau

    Microsoft Academic Search

    T. E. Browder; Y. Li; J. L. Rodriguez; H. Yamamoto; T. Bergfeld; B. I. Eisenstein; J. Ernst; G. E. Gladding; G. D. Gollin; R. M. Hans; E. Johnson; I. Karliner; M. A. Marsh; M. Palmer; C. Plager; C. Sedlack; M. Selen; J. J. Thaler; J. Williams; K. W. Edwards; R. Janicek; P. M. Patel; A. J. Sadoff; R. Ammar; P. Baringer; A. Bean; D. Besson; R. Davis; S. Kotov; I. Kravchenko; N. Kwak; X. Zhao; S. Anderson; V. V. Frolov; Y. Kubota; S. J. Lee; R. Mahapatra; J. J. O'neill; R. Poling; T. Riehle; A. Smith; S. Ahmed; M. S. Alam; S. B. Athar; L. Jian; L. Ling; A. H. Mahmood; M. Saleem; S. Timm; F. Wappler; A. Anastassov; J. E. Duboscq; K. K. Gan; C. Gwon; T. Hart; K. Honscheid; H. Kagan; R. Kass; J. Lorenc; H. Schwarthoff; E. von Toerne; M. M. Zoeller; S. J. Richichi; H. Severini; P. Skubic; A. Undrus; M. Bishai; S. Chen; J. Fast; J. W. Hinson; J. Lee; N. Menon; D. H. Miller; E. I. Shibata; I. P. Shipsey; Y. Kwon; A. L. Lyon; E. H. Thorndike; C. P. Jessop; K. Lingel; H. Marsiske; M. L. Perl; V. Savinov; D. Ugolini; X. Zhou; T. E. Coan; V. Fadeyev; I. Korolkov; Y. Maravin; I. Narsky; R. Stroynowski; J. Ye; T. Wlodek; M. Artuso; R. Ayad; E. Dambasuren; S. Kopp; G. Majumder; G. C. Moneti; S. Schuh; T. Skwarnicki; S. Stone; A. Titov; G. Viehhauser; J. C. Wang; A. Wolf; J. Wu; S. E. Csorna; K. W. McLean; S. Marka; Z. Xu; R. Godang; K. Kinoshita; I. C. Lai; P. Pomianowski; S. Schrenk; G. Bonvicini; D. Cinabro; R. Greene; L. P. Perera; G. J. Zhou; S. Chan; G. Eigen; E. Lipeles; M. Schmidtler; A. Shapiro; W. M. Sun; J. Urheim; A. J. Weinstein; F. Würthwein; D. E. Jaffe; G. Masek; H. P. Paar; E. M. Potter; S. Prell; V. Sharma; D. M. Asner; A. Eppich; J. Gronberg; T. S. Hill; D. J. Lange; R. J. Morrison; T. K. Nelson; J. D. Richman; R. A. Briere; B. H. Behrens; W. T. Ford; A. Gritsan; H. Krieg; J. Roy; J. G. Smith; J. P. Alexander; R. Baker; C. Bebek; B. E. Berger; K. Berkelman; F. Blanc; V. Boisvert; D. G. Cassel; M. Dickson; P. S. Drell; K. M. Ecklund; R. Ehrlich; A. D. Foland; P. Gaidarev; R. S. Galik; L. Gibbons; B. Gittelman; S. W. Gray; D. L. Hartill; B. K. Heltsley; P. I. Hopman; C. D. Jones; D. L. Kreinick; T. Lee; Y. Liu; T. O. Meyer; N. B. Mistry; C. R. Ng; E. Nordberg; J. R. Patterson; D. Peterson; D. Riley; J. G. Thayer; P. G. Thies; B. Valant-Spaight; A. Warburton; P. Avery; M. Lohner; C. Prescott; A. I. Rubiera; J. Yelton; J. Zheng; G. Brandenburg; A. Ershov; Y. S. Gao; D. Y.-J. Kim; R. Wilson

    2000-01-01

    Using the CLEO II detector operating at the Cornell Electron Storage Ring (CESR) e+e- collider, we have measured the structure functions in the decay tau-\\/+-->pi-\\/+pi0pi0nutau, based on a sample corresponding to 4×106 produced tau-pair events. We determine the integrated structure functions, which depend only on the three pion invariant mass, as well as the structure functions differential in the Dalitz

  11. What Renders TAU Toxic

    PubMed Central

    Götz, Jürgen; Xia, Di; Leinenga, Gerhard; Chew, Yee Lian; Nicholas, Hannah R.

    2013-01-01

    TAU is a microtubule-associated protein that under pathological conditions such as Alzheimer’s disease (AD) forms insoluble, filamentous aggregates. When 20?years after TAU’s discovery the first TAU transgenic mouse models were established, one declared goal that was achieved was the modeling of authentic TAU aggregate formation in the form of neurofibrillary tangles. However, as we review here, it has become increasingly clear that TAU causes damage much before these filamentous aggregates develop. In fact, because TAU is a scaffolding protein, increased levels and an altered subcellular localization (due to an increased insolubility and impaired clearance) result in the interaction of TAU with cellular proteins with which it would otherwise either not interact or do so to a lesser degree, thereby impairing their physiological functions. We specifically discuss the non-axonal localization of TAU, the role phosphorylation has in TAU toxicity and how TAU impairs mitochondrial functions. A major emphasis is on what we have learned from the four available TAU knock-out models in mice, and the knock-out of the TAU/MAP2 homolog PTL-1 in worms. It has been proposed that in human pathological conditions such as AD, a rare toxic TAU species exists which needs to be specifically removed to abrogate TAU’s toxicity and restore neuronal functions. However, what is toxic in one context may not be in another, and simply reducing, but not fully abolishing TAU levels may be sufficient to abrogate TAU toxicity. PMID:23772223

  12. Search for Higgs bosons decaying to tau(+)tau(-) pairs in p(p)over-bar collisions at root s=1.96 TeV

    SciTech Connect

    Abazov, V.M.; Abazov, V. M.; Abbott, B.; Achary, B. S.; Adams, M.; Adams, T.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Alverson, G.; Alves, G. A.; Aoki, M.; Arov, M.; Askew, A.; Asman, B.; Atramentov, O.; Avila, C.; BackusMayes, J.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Barreto, J.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Beale, S.; Bean, A.; Begalli, M.; Begel, M.; Belanger-Champagne, C.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besancon, M.; Beuselinck, R.; Bezzubov, V. A.; Bhat, P. C.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Bose, T.; Brandt, A.; Brandt, O.; Brock, R.; Brooijmans, G.; Bross, A.; Brown, D.; Brown, J.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Burnett, T. H.; Buszello, C. P.; Calpas, B.; Camacho-Perez, E.; Carrasco-Lizarraga, M. A.; Casey, B. C. K.; Castilla-Valdez, H.; Chakrabarti, S.; Chakraborty, D.; Chan, K. M.; Chandra, A.; Chen, G.; Chevalier-Thery, S.; Cho, D. K.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Croc, A.; Cutts, D.; Das, A.; Davies, G.; De, K.; de Jong, S. J.; De La Cruz-Burelo, E.; Deliot, F.; Demarteau, M.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dorland, T.; Dubey, A.; Dudko, L. V.; Duggan, D.; Duperrin, A.; Dutt, S.; Dyshkant, A.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, A.; Evdokimov, V. N.; Facini, G.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garcia-Bellido, A.; Gavrilov, V.; Gay, P.; Geng, W.; Gerbaudo, D.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Golovanov, G.; Goussiou, A.; Grannis, P. D.; Greder, S.; Greenlee, H.; Greenwood, Z. D.; Gregores, E. M.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjea, A.; Gruenendahl, S.; Gruenewald, M. W.; Guillemin, T.; Guo, F.; Gutierrez, G.; Gutierrez, P.; Haas, A.; Hagopia, S.; Haley, J.; Hang, L.; Harder, K.; Harein, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoangau, T.; Hobbs, J. D.; Hoeneisen, B.; Hohlfeld, M.; Hubacek, Z.; Huske, N.; Hynek, V.; Lashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffre, M.; Jamin, D.; Jayasinghe, A.; Jesik, R.; Johns, K.; Johnson, M.; Johnston, D.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kaadze, K.; Kajfasz, E.; Karmanov, D.; Kasper, P. A.; Katsanos, I. I.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kirby, M. H.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kulikov, S.; Kumar, A.; Kupco, A.; Kurca, T.; Kuzmin, V. A.; Kvita, J.; Lammers, S.; Landsberg, G.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lellouch, J.; Li, L.; Li, Q. Z.; Lietti, S. M.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, Y.; Liu, Z.; Lobodenko, A.; Lokajicek, M.; de Sa, R. Lopes; Lubatti, H. J.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Mackin, D.; Madar, R.; Magana-Villalba, R.; Malik, S.; Malyshev, V. L.; Maravin, Y.; Martinez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; et al.

    2012-02-01

    We present a search for the production of neutral Higgs bosons decaying into {tau}{sup +}{tau}{sup -} pairs in p{bar p} collisions at a center-of-mass energy of 1.96 TeV. The data, corresponding to an integrated luminosity of 5.4 fb{sup -1}, were collected by the D0 experiment at the Fermilab Tevatron Collider. We set upper limits at the 95% C.L. on the product of production cross section and branching ratio for a scalar resonance decaying into {tau}{sup +}{tau}{sup -} pairs, and we interpret these limits as limits on the production of Higgs bosons in the minimal supersymmetric standard model (MSSM) and as constraints in the MSSM parameter space.

  13. Search for Lepton Flavour Violating Decays Tau -> l Ks with the BABAR Detector

    SciTech Connect

    Cenci, Riccardo; /SLAC

    2009-03-20

    We present the search for the lepton flavour violating decay {tau} {yields} lK{sup 0}{sub s} with the BaBar experiment data. This process and many other lepton flavour violating {tau} decays, like {tau} {yields} {mu}{gamma} and {tau} {yields} lll, are one of the most promising channel to search for evidence of new physics. According to the Standard Model and the neutrino mixing parameters, branching fractions are estimated well below 10{sup -14}, but many models of new physics allow for branching fractions values close to the present experimental sensitivity. This analysis is based on a data sample of 469fb{sup -1} collected by BABAR detector at the PEP-II storage ring from 1999 to 2007, equivalent to 431 millions of {tau} pairs. the BABAR experiment, initially designed for studying CP violation in B mesons, has demonstrated to be one of the most suitable environments for studying {tau} decays. The tracking system, the calorimeter and the particle identification of BABAR, together with the knowledge of the {tau} initial energy, allow an extremely powerful rejection of background events that, for this analysis, is better than 10{sup -9}. Being {tau} {yields} lK{sup 0}{sub s} a decay mode without neutrinos, the signal {tau} decay can be fully reconstructed. Kinematical constraints are used in a fit that provides a decay tree reconstruction with a high resolution. For this analysis MC simulated events play a decisive role for estimating the signal efficiency and study the residual background. High statistics MC sample are produced simulating detector conditions for different periods of data collection, in order to reduce any discrepancies with the data. When discrepancies can not be removed, we perform studies to compute a correction factor or an estimation of systematic errors that need to be included in the final measurement. A significant improvement of the current result can be reached only with a higher statistics and, therefore, with a new collider providing a luminosity from 10 to 100 times more than PEP-II. A new detector, with improved performance and able to collect data in a high background environment, is also requested to fully exploit the capability of such amount of data. In fact, only keeping the efficiency and the background as similar as possible to present ones, we will be able to scale almost linearly the estimated upper limit according to the luminosity. The strong potential of improvement for the search of lepton flavour violation {tau} decays makes the building of such a machine highly desirable.

  14. Tau identification at the Tevatron

    SciTech Connect

    Levy, Stephen; /Chicago U., EFI

    2005-07-01

    Methods for reconstructing and identifying the hadronic decays of tau leptons with the CDF and D0 detectors at the Fermilab Tevatron collider in Run II are described. Precision electroweak measurements of W and Z gauge boson cross sections are presented as well as results of searches for physics beyond the Standard Model with hadronically decaying tau leptons in the final state.

  15. Observation of the Semileptonic Decays B to D*taunu and Evidence for B to D tau nu

    SciTech Connect

    B., Aubert

    2007-09-14

    We present measurements of the semileptonic decays B{sup -} {yields} D{sup 0}{tau}{sup -}{bar {nu}}{sub {tau}}, B{sup -} {yields} D{sup *0}{tau}{sup -}{bar {nu}}{sub {tau}}, B{sup -} {yields} D{sup +}{tau}{sup -}{bar {nu}}{sub {tau}}, and B{sup -} {yields} D{sup *+}{tau}{sup -}{bar {nu}}{sub {tau}}, which are potentially sensitive to non-Standard Model amplitudes, The data sample comprises 232 x 10{sup 6} {Upsilon}(4s) {yields} B{bar B} decays collected with the BABAR detector. From a combined fit to B{sup -} and {bar B}{sup 0} channels, we obtain the branching fractions {beta}(B {yields} D{sub {tau}}{sup -}{bar {nu}}{sub {tau}}) = (0:86 {+-} 0:24 {+-} 0:11 {+-} 0:06)% and {beta}(B {yields} D*{tau}{sup -}{bar {nu}}{sub {tau}}) = (1:62 {+-} 0:31 {+-} 0:10 {+-} 0:05)% (normalized for the {bar B}{sup 0}), , where the uncertainties are statistical, systematic, and normalization-mode-related.

  16. A Study of Three-Prong $\\\\tau$ Decays with Charged Kaons

    Microsoft Academic Search

    K Ackerstaff; Gideon Alexander; J Allison; K J Anderson; S Anderson; S Arcelli; S Asai; S F Ashby; D A Axen; Georges Azuelos; A H Ball; E Barberio; R J Barlow; J Richard Batley; S Baumann; J Bechtluft; T Behnke; K W Bell; G Bella; A Bellerive; Stanislaus Cornelius Maria Bentvelsen; Siegfried Bethke; S Betts; O Biebel; A Biguzzi; Ian J Bloodworth; P Bock; J Böhme; O Boeriu; D Bonacorsi; M Boutemeur; S Braibant; P G Bright-Thomas; L Brigliadori; R M Brown; Helfried J Burckhart; P Capiluppi; R K Carnegie; A A Carter; J R Carter; C Y Chang; D G Charlton; D Chrisman; C Ciocca; P E L Clarke; E Clay; I Cohen; J E Conboy; O C Cooke; J Couchman; C Couyoumtzelis; R L Coxe; M Cuffiani; S Dado; G M Dallavalle; S Dallison; R Davis; S De Jong; A de Roeck; P J Dervan; Klaus Desch; B Dienes; M S Dixit; M Donkers; J Dubbert; E Duchovni; G Duckeck; I P Duerdoth; P G Estabrooks; E Etzion; Franco Luigi Fabbri; A Fanfani; M Fanti; A A Faust; L Feld; P Ferrari; F Fiedler; M Fierro; I Fleck; A Frey; A Fürtjes; D I Futyan; P Gagnon; J W Gary; G Gaycken; C Geich-Gimbel; G Giacomelli; P Giacomelli; W R Gibson; D M Gingrich; D A Glenzinski; J Goldberg; W Gorn; C Grandi; K Graham; E Gross; Jacob Grunhaus; M Gruwé; C Hajdu; G G Hanson; M Hansroul; M Hapke; K Harder; A Harel; C K Hargrove; M Harin-Dirac; M Hauschild; C M Hawkes; R Hawkings; Richard J Hemingway; G Herten; R D Heuer; M D Hildreth; J C Hill; P R Hobson; Andreas Höcker; K Hoffman; R James Homer; A K Honma; D Horváth; K R Hossain; R Howard; P Hüntemeyer; P Igo-Kemenes; D C Imrie; K Ishii; F R Jacob; A Jawahery; H Jeremie; Martin Paul Jimack; C R Jones; P Jovanovic; T R Junk; N Kanaya; J I Kanzaki; D A Karlen; V G Kartvelishvili; K Kawagoe; T Kawamoto; P I Kayal; Richard K Keeler; R G Kellogg; B W Kennedy; D H Kim; A Klier; T Kobayashi; M Kobel; T P Kokott; M Kolrep; S Komamiya; R V Kowalewski; T Kress; P Krieger; J Von Krogh; T Kühl; P Kyberd; G D Lafferty; Hagar Yaël Landsman; D Lanske; J Lauber; I Lawson; J G Layter; Daniel Lellouch; J Letts; L Levinson; R Liebisch; J Lillich; B List; C Littlewood; A W Lloyd; S L Lloyd; F K Loebinger; G D Long; Michael J Losty; J Lü; J Ludwig; D Liu; A Macchiolo; A L MacPherson; W F Mader; M Mannelli; S Marcellini; T E Marchant; A J Martin; J P Martin; G Martínez; T Mashimo; P Mättig; W J McDonald; J A McKenna; E A McKigney; T J McMahon; R A McPherson; F Meijers; P Méndez-Lorenzo; F S Merritt; H Mes; I Meyer; Aldo Michelini; S Mihara; G Mikenberg; D J Miller; W Mohr; A Montanari; T Mori; K Nagai; I Nakamura; H A Neal; R Nisius; S W O'Neale; F G Oakham; F Odorici; H O Ögren; A N Okpara; M J Oreglia; S Orito; G Pásztor; J R Pater; G N Patrick; J Patt; R Pérez-Ochoa; S Petzold; P Pfeifenschneider; J E Pilcher; James L Pinfold; D E Plane; P R Poffenberger; B Poli; J Polok; M B Przybycien; A Quadt; C Rembser; Hartmut Rick; S Robertson; S A Robins; N L Rodning; J M Roney; S Rosati; K Roscoe; A M Rossi; Y Rozen; K Runge; O Runólfsson; D R Rust; K Sachs; T Saeki; O Sahr; W M Sang; E Sarkisyan-Grinbaum; C Sbarra; A D Schaile; O Schaile; P Scharff-Hansen; J Schieck; S Schmitt; A Schöning; M Schröder; M Schumacher; C Schwick; W G Scott; R Seuster; T G Shears; B C Shen; C H Shepherd-Themistocleous; P Sherwood; G P Siroli; A Skuja; A M Smith; G A Snow; Randall J Sobie; S Söldner-Rembold; S Spagnolo; M Sproston; A Stahl; K Stephens; K Stoll; D Strom; R Ströhmer; B Surrow; S D Talbot; P Taras; S Tarem; R Teuscher; M Thiergen; J Thomas; M A Thomson; E Torrence; S Towers; T M Trefzger; I Trigger; Z L Trócsányi; E Tsur; M F Turner-Watson; I Ueda; R Van Kooten; P Vannerem; M Verzocchi; H Voss; F Wäckerle; A Wagner; D Waller; C P Ward; D R Ward; P M Watkins; A T Watson; N K Watson; P S Wells; N Wermes; D Wetterling; J S White; G W Wilson; J A Wilson; T R Wyatt; S Yamashita; V Zacek; D Zer-Zion

    2000-01-01

    From an analysis of the ionisation energy loss of charged particles selected from a sample of 147926 e+e- -> tau+tau- candidates recorded in the OPAL detector at e+e- centre-of-mass energies near the Z0 resonance, we determine the branching ratios: BR(tau- -> nu_tau K- pi- pi+ (pi0)) = 0.343 +- 0.073 +- 0.031 % BR(tau- -> nu_tau K- pi- K+ (pi0))

  17. SMUHEP 01-03 Search for CP violation in tau decays.

    E-print Network

    SMUHEP 01-03 Search for CP violation in tau decays. Y. Maravin a #3; a Physics Department, Southern of the searches for CP non-conservation in the decays of #28; leptons are presented. No evidence of violation of CP symmetry is observed neither in CLEO nor in BELLE data. Interpretation of these results is done

  18. Measurement of the Branching Fraction for D8+ rarr tau+nu_tau and Extraction of the Decay Constant f_D_s

    SciTech Connect

    Lees, J.P.; Poireau, V.; Prencipe, E.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Battaglia, M.; Brown, D.N.; Hooberman, B.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; Tanabe, T.; /UC, Berkeley; Hawkes, C.M.; /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Indian Inst. Tech., Guwahati /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2010-06-04

    The branching fraction for the decay D{sub s}{sup +} {yields} {tau}{sup +}{nu}{sub {tau}} with {tau}{sup +} {yields} e{sup +}{bar {nu}}{sub {tau}}, is measured using a data sample corresponding to an integrated luminosity of 427 fb{sup -1} collected at center of mass energies near 10.58 GeV with the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} collider at SLAC. In the process e{sup +}e{sup -} {yields} c{bar c} {yields} D*{sub s}{sup +} {bar D}{sub TAG}{bar K}X, the D*{sub s}{sup +} meson is reconstructed as a missing particle, and the subsequent decay D*{sub s}{sup +} {yields} D{sub s}{sup +}{gamma} yields an inclusive D{sub s}{sup +} data sample. Here {bar D}{sub TAG} refers to a fully reconstructed hadronic {bar D} decay, {bar K} is a K{sup -} or {bar K}{sup 0}, and X stands for any number of charged or neutral pions. The decay D{sub s}{sup +} {yields} K{sub S}{sup 0}K{sup +} is isolated also, and from ratio of event yields and known branching fractions, {Beta}(D{sub s}{sup +} {yields} {tau}{sup +}{nu}{sub {tau}}) = (4.5 {+-} 0.5 {+-} 0.4 {+-} 0.3)% is determined. The pseudoscalar decay constant is extracted to be f{sub D{sub s}} = (233 {+-} 13 {+-} 10 {+-} 7) MeV, where the first uncertainty is statistical, the second is systematic, and the third results from the uncertainties on the external measurements used as input to the calculation.

  19. A Search for the Rare Leptonic B- to tau- anti-neutrino Recoiling against B+ to Decays to anti-D*0 l+ Lepton-neutrino

    SciTech Connect

    Datta, Mousumi; /Wisconsin U., Madison

    2006-10-17

    This thesis describes a search for the decay B{sup -} {yields} {tau}{sup -}{bar {nu}}{sub {tau}} in 231.8 x 10{sup 6} {Upsilon}(4S) decays recorded with the BABAR detector at the SLAC PEP-II B-Factory. A sample of events with one reconstructed exclusive semi-leptonic B decay (B{sup +} {yields} {bar D}*{sup 0} {ell}{sup +}{nu}{sub {ell}}) is selected, and in the recoil a search for B{sup -} {yields} {tau}{sup -} {bar {nu}}{sub {tau}} signal is performed in the following {tau} decay modes: {tau}{sup -} {yields} e{sup -}{bar {nu}}{sub e}{nu}{sub {tau}}, {tau}{sup -} {yields} {mu}{sup -}{bar {nu}}{sub {mu}}{nu}{sub {tau}}, {tau}{sup -} {yields} {pi}{sup -}{nu}{sub {tau}}, {tau}{sup -} {yields} {pi}{sup -}{pi}{sup 0}{nu}{sub {tau}}, and {tau}{sup -} {yields} {pi}{sup -}{pi}{sup +}{pi}{sup -}{nu}{sub {tau}}. They find no evidence of signal, and they set a preliminary upper limit on the branching fraction of {beta}(B{sup -} {yields} {tau}{sup -}{bar {nu}}{sub {tau}}) < 2.8 x 10{sup -4} at the 90% confidence level (CL). This result is then combined with a statistically independent BABAR search for B{sup -} {yields} {tau}{sup -}{bar {nu}}{sub {tau}} to give a combined preliminary limit of {Beta}(B{sup -} {yields} {tau}{sup -}{bar {nu}}{sub {tau}}) < 2.6 x 10{sup -4} at 90% CL.

  20. Search for B+-->tau+nu

    Microsoft Academic Search

    B. Aubert; M. Bona; D. Boutigny; Y. Karyotakis; J. P. Lees; V. Poireau; X. Prudent; V. Tisserand; A. Zghiche; J. Garra Tico; E. Grauges; L. Lopez; A. Palano; G. Eigen; B. Stugu; L. Sun; G. S. Abrams; M. Battaglia; D. N. Brown; J. Button-Shafer; R. N. Cahn; Y. Groysman; R. G. Jacobsen; J. A. Kadyk; L. T. Kerth; Yu. G. Kolomensky; G. Kukartsev; D. Lopes Pegna; G. Lynch; L. M. Mir; T. J. Orimoto; M. T. Ronan; K. Tackmann; W. A. Wenzel; P. Del Amo Sanchez; C. M. Hawkes; A. T. Watson; T. Held; H. Koch; B. Lewandowski; M. Pelizaeus; T. Schroeder; M. Steinke; D. Walker; D. J. Asgeirsson; T. Cuhadar-Donszelmann; B. G. Fulsom; C. Hearty; T. S. Mattison; J. A. McKenna; A. Khan; M. Saleem; L. Teodorescu; V. E. Blinov; A. D. Bukin; V. P. Druzhinin; V. B. Golubev; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; K. Yu. Todyshev; M. Bondioli; S. Curry; I. Eschrich; D. Kirkby; A. J. Lankford; P. Lund; M. Mandelkern; E. C. Martin; D. P. Stoker; S. Abachi; C. Buchanan; S. D. Foulkes; J. W. Gary; F. Liu; O. Long; B. C. Shen; L. Zhang; H. P. Paar; S. Rahatlou; V. Sharma; J. W. Berryhill; C. Campagnari; A. Cunha; B. Dahmes; T. M. Hong; D. Kovalskyi; J. D. Richman; T. W. Beck; A. M. Eisner; C. J. Flacco; C. A. Heusch; J. Kroseberg; W. S. Lockman; T. Schalk; B. A. Schumm; A. Seiden; D. C. Williams; M. G. Wilson; L. O. Winstrom; E. Chen; C. H. Cheng; F. Fang; D. G. Hitlin; I. Narsky; T. Piatenko; F. C. Porter; R. Andreassen; G. Mancinelli; B. T. Meadows; K. Mishra; M. D. Sokoloff; F. Blanc; P. C. Bloom; S. Chen; W. T. Ford; J. F. Hirschauer; A. Kreisel; M. Nagel; U. Nauenberg; A. Olivas; J. G. Smith; K. A. Ulmer; S. R. Wagner; J. Zhang; A. M. Gabareen; A. Soffer; W. H. Toki; R. J. Wilson; F. Winklmeier; Q. Zeng; D. D. Altenburg; E. Feltresi; A. Hauke; H. Jasper; J. Merkel; A. Petzold; B. Spaan; K. Wacker; T. Brandt; V. Klose; M. J. Kobel; H. M. Lacker; W. F. Mader; R. Nogowski; J. Schubert; K. R. Schubert; R. Schwierz; J. E. Sundermann; A. Volk; D. Bernard; G. R. Bonneaud; E. Latour; V. Lombardo; Ch. Thiebaux; M. Verderi; P. J. Clark; W. Gradl; F. Muheim; S. Playfer; A. I. Robertson; Y. Xie; M. Andreotti; D. Bettoni; C. Bozzi; R. Calabrese; A. Cecchi; G. Cibinetto; P. Franchini; E. Luppi; M. Negrini; A. Petrella; L. Piemontese; E. Prencipe; V. Santoro; F. Anulli; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; G. Finocchiaro; S. Pacetti; P. Patteri; I. M. Peruzzi; M. Piccolo; M. Rama; A. Zallo; A. Buzzo; R. Contri; M. Lo Vetere; M. M. Macri; M. R. Monge; S. Passaggio; C. Patrignani; E. Robutti; A. Santroni; S. Tosi; K. S. Chaisanguanthum; M. Morii; J. Wu; R. S. Dubitzky; J. Marks; S. Schenk; U. Uwer; D. J. Bard; P. D. Dauncey; R. L. Flack; J. A. Nash; M. B. Nikolich; W. Panduro Vazquez; M. Tibbetts; P. K. Behera; X. Chai; M. J. Charles; U. Mallik; N. T. Meyer; V. Ziegler; J. Cochran; H. B. Crawley; L. Dong; V. Eyges; W. T. Meyer; S. Prell; E. I. Rosenberg; A. E. Rubin; A. V. Gritsan; Z. J. Guo; C. K. Lae; A. G. Denig; M. Fritsch; G. Schott; N. Arnaud; J. Béquilleux; M. Davier; G. Grosdidier; A. Höcker; V. Lepeltier; F. Le Diberder; A. M. Lutz; S. Pruvot; S. Rodier; P. Roudeau; M. H. Schune; J. Serrano; V. Sordini; A. Stocchi; W. F. Wang; G. Wormser; D. J. Lange; D. M. Wright; I. Bingham; C. A. Chavez; I. J. Forster; J. R. Fry; E. Gabathuler; R. Gamet; D. E. Hutchcroft; D. J. Payne; K. C. Schofield; C. Touramanis; A. J. Bevan; K. A. George; F. di Lodovico; W. Menges; R. Sacco; G. Cowan; H. U. Flaecher; D. A. Hopkins; S. Paramesvaran; F. Salvatore; A. C. Wren; C. L. Davis; J. Allison; N. R. Barlow; R. J. Barlow; Y. M. Chia; C. L. Edgar; G. D. Lafferty; T. J. West; J. I. Yi; J. Anderson; C. Chen; A. Jawahery; D. A. Roberts; G. Simi; J. M. Tuggle; G. Blaylock; C. Dallapiccola; S. S. Hertzbach; X. Li; T. B. Moore; E. Salvati; S. Saremi; R. Cowan; D. Dujmic; P. H. Fisher; K. Koeneke; G. Sciolla; S. J. Sekula; M. Spitznagel; F. Taylor; R. K. Yamamoto; M. Zhao; Y. Zheng; S. E. McLachlin; P. M. Patel; S. H. Robertson; A. Lazzaro; F. Palombo; J. M. Bauer; L. Cremaldi; V. Eschenburg; R. Godang; R. Kroeger; D. A. Sanders; D. J. Summers; H. W. Zhao; S. Brunet; D. Côté; M. Simard; P. Taras; F. B. Viaud; H. Nicholson; G. de Nardo; F. Fabozzi; L. Lista; D. Monorchio; C. Sciacca; M. A. Baak; G. Raven; H. L. Snoek; C. P. Jessop; J. M. Losecco; G. Benelli; L. A. Corwin; K. Honscheid; H. Kagan; R. Kass; J. P. Morris; A. M. Rahimi; J. J. Regensburger; Q. K. Wong; N. L. Blount; J. Brau; R. Frey; O. Igonkina; J. A. Kolb; M. Lu; R. Rahmat; N. B. Sinev; D. Strom; J. Strube; E. Torrence; N. Gagliardi; A. Gaz; M. Margoni; M. Morandin; A. Pompili; M. Posocco; M. Rotondo; F. Simonetto; R. Stroili; C. Voci; E. Ben-Haim; H. Briand; G. Calderini; J. Chauveau; P. David; L. Del Buono; Ch. de La Vaissière; O. Hamon; Ph. Leruste; J. Malclès; J. Ocariz; A. Perez; L. Gladney; M. Biasini

    2007-01-01

    We present a search for the decay B+-->tau+nu using 383×106BB¯ pairs collected at the Upsilon(4S) resonance with the BABAR detector at the SLAC PEP-II B-Factory. A sample of events with one reconstructed semileptonic B decay (B--->D0l-nu¯lX) is selected, and in the recoil a search for B+-->tau+nu is performed. The tau is identified in the following channels: tau+-->e+nunu¯, tau+-->mu+nunu¯, tau+-->pi+nu¯, and

  1. Tau decays with one charged particle plus multiple pi(0)'s

    E-print Network

    Ammar, Raymond G.; Ball, S.; Baringer, Philip S.; Coppage, Don; Copty, N.; Davis, Robin E. P.; Hancock, N.; Kelly, M.; Kwak, Nowhan; Lam, H.

    1993-03-01

    With the CLEO-II detector at the Cornell Electron Storage Ring, we have measured branching fractions for tau lepton decay into one-prong final states with multiple pi0's, B(hnpi)0, normalized to the branching fraction for ...

  2. TauSpinner: a tool for simulating CP effects in decays at LHC

    NASA Astrophysics Data System (ADS)

    Przedzi?ski, T.; Richter-Wa¸s, E.; Wa¸s, Zbigniew

    2014-11-01

    In this paper, we discuss application of the TauSpinner package as a simulation tool for measuring the CP state of the newly discovered Higgs boson using the transverse spin correlations in the decay channel. We discuss application for its main background as well. The TauSpinner package allows to add, with the help of weights, transverse spin correlations corresponding to any mixture of scalar/pseudoscalar state, on already existing events using information from the kinematics of outgoing leptons and their decay products only. This procedure can be used when polarimetric vectors of the s decays and density matrix for -pair production are not stored with the event sample. We concentrate on the well-defined effects for the Higgs (or Higgs-like scalar) decays, which are physically separated from the production processes. TauSpinner also allows to reintroduce (or remove) spin correlations to events from Drell-Yan process, the main background for the Higgs parity observables, again with the help of weights only. From the literature, we recall well-established observables, developed for measuring the CP of the Higgs, and use them as benchmarks for illustrating applications of the TauSpinner package. We also include a description of the code and prepared testing examples.

  3. Search for Lepton Flavor Violating Decays tau--->l-Ks0 with the BABAR Experiment

    E-print Network

    Fisher, Peter H.

    A search for the lepton flavor violating decays tau--->l-KS0 (l=e or mu) has been performed using a data sample corresponding to an integrated luminosity of 469??fb[superscript -1], collected with the BABAR detector at the ...

  4. A study of the decays of tau leptons produced on the Z resonance at LEP

    Microsoft Academic Search

    P. Abreu; W. Adam; T. Adye; E. Agasi; G. D. Alekseev; P. Allen; S. Almehed; S. J. Alvsvaag; U. Amaldi; E. G. Anassontzis; A. Andreazza; P. Antilogus; W.-D. Apel; R. J. Apsimon; B. Åsman; J.-E. Augustin; A. Augustinus; P. Baillon; P. Bambade; F. Barao; R. Barate; G. Barbiellini; D. Y. Bardin; A. Baroncelli; O. Barring; J. A. Barrio; W. Bartl; M. Berggren; M. Battaglia; M. Baubillier; K.-H. Becks; C. J. Beeston; M. Begalli; P. Beilliere; Yu. Belokopytov; P. Beltran; D. Benedic; D. Bertrand; F. Bianchi; M. S. Bilenky; P. Billoir; J. Bjarne; D. Bloch; S. Blyth; V. Bocci; P. N. Bogolubov; T. Bolognese; M. Bonesini; W. Bonivento; P. S. L. Booth; P. Borgeaud; G. Borisov; H. Borner; C. Bosio; B. Bostjancic; S. Bosworth; O. Botner; B. Bouquet; C. Bourdarios; T. J. V. Bowcock; M. Bozzo; S. Braibant; P. Branchini; K. D. Brand; R. A. Brenner; H. Briand; C. Bricman; R. C. A. Brown; N. Brummer; J.-M. Brunet; L. Bugge; T. Buran; H. Burmeister; J. A. M. A. Buytaert; M. Caccia; M. Calvi; A. J. Camacho Rozas; T. Camporesi; V. Canale; F. Couchot; F. Carena; L. Carroll; Carlo Caso; Edoardo Castelli; M. V. Castillo Gimenez; A. Cattai; F. R. Cavallo; L. Cerrito; V. Chabaud; A. Chan; Ph. Charpentier; L. Chaussard; J. Chauveau; P. Checchia; G. A. Chelkov; L. Chevalier; P V Chliapnikov; V. Chorowicz; J. T. M. Chrin; R. Cirio; M. P. Clara; P. Collins; J. L. Contreras; R. Contri; E. Cortina; G. Cosme; H. B. Crawley; D J Crennell; G. Crosetti; M. Crozon; J. Cuevas Maestro; S. Czellar; S. Dagoret; Erik Dahl-Jensen; B. Dalmagne; M. Dam; G. Damgaard; G. Darbo; Evelyne Daubie; A. Daum; P. D. Dauncey; Martyn Davenport; P. David; W. Da Silva; C. Defoix; D. Delikaris; B. A. Della Riccia; S. Delorme; P A Delpierre; N. Demaria; A. De Angelis; M. De Beer; H. De Boeck; Wim de Boer; C. De Clercq; M. D. M. De Fez Laso; N. De Groot; C. De La Vaissiere; B. De Lotto; A. De Min; H. Dijkstra; Lucia Di Ciaccio; F. Djama; J. Dolbeau; M. Donszelmann; K. Doroba; M. Dracos; J. Drees; M. Dris; Y. Dufour; L.-O. Eek; P. A.-M. Eerola; R. Ehret; T. Ekelof; G. Ekspong; A. Elliot Peisert; J.-P. Engel; D. Fassouliotis; T. A. Fearnley; Michael Feindt; A. Fenyuk; M. Fernandez Alonso; A. Ferrer; T. A. Filippas; A. Firestone; H. Foeth; E. Fokitis; F. Fontanelli; K. A. J. Forbes; B. Franek; P. Frenkiel; D. C. Fries; A. G. Frodesen; R. Fruhwirth; F. Fulda-Quenzer; K. Furnival; H. Furstenau; J. Fuster; G. Galeazzi; D. Gamba; C. Garcia; J. Garcia; C. Gaspar; U. Gasparini; Ph. Gavillet; E. N. Gazis; J.-P. Gerber; P. Giacomelli; R. Gokieli; B. Bolob; V. M. Golovatyuk; J. J. Gomez Y Cadenas; A. Goobar; G. Gopal; M. Gorski; V. Gracco; A. Grant; F. Grard; E. Graziani; G. Grosadidier; E. Gross; P. Grosse-Wiesmann; B. Grossetete; S. Gumenyuk; J. Guy; U. Haedinger; F. Hahn; M. Hahn; S. Haider; Z. Hajduk; A. Hakansson; K. Hamacher; G. Hamel De Monchenault; W. Hao; F. J. Harris; T. Henkes; J. J. Hernandez; P. Herquet; H. Herr; T. L. Hessing; I. Hietanen; C. O. Higgins; E. Higon; H. J. Hilke; S. D. Hodgson; T. Hofmokl; R. Holmes; S.-O. Holmgren; D. Holthuizen; P. F. Honore; J. E. Hooper; M. Houlden; P. O. Hulth; K. Hultqvist; P. Ioannou; D. Isenhower; P.-S. Iversen; J. N. Jackson; P. Jalocha; G. Jarlskog; B. Jean-Marie; E. K. Johansson; D. Johnson; M. Jonker; L. Jonsson; P. Juillot; G. Kalkanis; G. Kalmus; F. Kapusta; M. Karlsson; E. Karvelas; S. Katsanevas; E. C. Katsoufis; R. Keranen; J. Kesteman; B. A. Khomenko; N. N. Khovanski; J. J. Kjaer; H. Klein; W. Klempt; A. Klovning; P. Kluit; A. Koch-Mehrin; J. H. Koehne; B. Koene; P. Kokkinias; M. Kopf; K. Korcyl; A. V. Korytov; V. Kostioukhine; C. Kourkoumelis; O. Kouznetsov; P. H. Kramer; J. Krolikowski; I. Kronkvist; J. Krstic; U. Kruener-Marquis; W. Krupinski; K. Kulka; K. Kurvinen; C. Lacasta; C. Lambropoulos; J. W. Lamsa; L. Lanceri; V. Lapin; J.-P. Laugier; R. Lauhakangas; G. Leder; F. Ledroit; R. Leitner; Y. Lemoigne; J. Lemonne; G. Lenzen; V. Lepeltier; J. M. Levy; E. Lieb; D. Liko; E. Lillethun; J. Lindgren; R. Lindner; A. Lipniacka; I. Lippi; B. Loerstad; M. Lokajicek; J. G. Loken; A. Lopez-Fernandez; M. A. Lopez Aguera; M A López-Aguera; D. Loukas; J. J. Lozano; P. Lutz; L. Lyons; G. Maehlum; J. Maillard; A. Maltezos; F. Mandl; J. Marco; M. Margoni; J.-C. Marin; A. Markou; T. Maron; S. Marti; L. Mathis; F. Matorras; C. Matteuzzi; G. Matthiae; M. Mazzucato; M. McCubbin; R. Mc Kay; R. Mc Nulty; G. Meola; C. Meroni; W. T. Meyer; M. Michelotto; I. Mikulec; W. A. Mitaroff; G. V. Mitselmakher; U. Mjoernmark; T. Moa; R. Moeller; K. Moenig; M. R. Monge; P. Morettini; H. Mueller; W. J. Murray; B. Muryn; G. Myatt; F. Naraghi; F. L. Navarria; P. Negri; B. S. Nielsen; B. Nijjhar; V. Nikolaenko; P. E. S. Nilsen; P. Niss; V. Obraztsov; A. G. Olshevski; R. Orava; A. Ostankov; K. Osterberg; A. Ouraou; M. Paganoni; R. Pain; H. Palka; Th. D. Papadopoulou; L. Pape

    1992-01-01

    From the analysis of a data sample corresponding to an integrated luminosity of 4.63 pb-1 taken during the 1990 run of LEP at centre of mass energies between 88.2 GeV an 94.2 GeV, the tau decays\\u000a

  5. Search for Lepton Flavour Violating Decays tau- to l- Ks with the BaBar experiment

    SciTech Connect

    Aubert, B.; Bona, M.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Lopez, L.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Abrams, G.S.; Battaglia, M.; Brown, D.N.; Cahn, R.N.; Jacobsen, R.G.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /Bristol U. /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Karlsruhe U., EKP /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DSM, DAPNIA, Saclay /South Carolina U. /SLAC /Stanford U., Phys. Dept. /SUNY, Albany /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-01-06

    A search for the lepton flavor violating decays {tau}{sup -} {yields} l{sup -} K{sub S}{sup 0} (l = e or {mu}) has been performed using a data sample corresponding to an integrated luminosity of 469 fb{sup -1}, collected with the BABAR detector at the SLAC PEP-II e{sup +}e{sup -} asymmetric energy collider. No statistically significant signal has been observed in either channel and the estimated upper limits on branching fractions are {Beta}({tau}{sup -} {yields} e{sup -} K{sub S}{sup 0}) < 3.3 x 10{sup -8} and {Beta}({tau}{sup -} {yields} {mu}{sup -}K{sub S}{sup 0}) < 4.0 x 10{sup -8} at 90% confidence level.

  6. Search for High-Mass Resonances Decaying into Leptons of Different Flavor (e mu, e tau, mu tau) in p anti-p Collisions at sqrt(s) = 1.96 TeV

    SciTech Connect

    Tu, Yanjun; /Pennsylvania U.

    2008-10-01

    We present a search for high-mass resonances decaying into two leptons of different flavor: e{mu}, e{tau}, and {mu}{tau}. These resonances are predicted by several models beyond the standard model, such as the R-parity-violating MSSM. The search is based on 1 fb{sup -1} of data collected at the Collider Detector at Fermilab (CDF II) in proton anti-proton collisions. Our observations are consistent with the standard model expectations. The results are interpreted to set 95% C.L. upper limits on {sigma} x BR of {tilde {nu}}{sub {tau}} {yields} e{mu}, e{tau}, {mu}{tau}.

  7. Search for Lepton-Flavor Violation in the Decay tau--->l-l+l-

    Microsoft Academic Search

    B. Aubert; R. Barate; D. Boutigny; F. Couderc; J.-M. Gaillard; A. Hicheur; Y. Karyotakis; J. P. Lees; V. Tisserand; A. Zghiche; A. Palano; A. Pompili; J. C. Chen; N. D. Qi; G. Rong; P. Wang; Y. S. Zhu; G. Eigen; I. Ofte; B. Stugu; G. S. Abrams; A. W. Borgland; A. B. Breon; D. N. Brown; J. Button-Shafer; R. N. Cahn; E. Charles; C. T. Day; M. S. Gill; A. V. Gritsan; Y. Groysman; R. G. Jacobsen; R. W. Kadel; J. Kadyk; L. T. Kerth; Yu. G. Kolomensky; G. Kukartsev; C. Leclerc; M. E. Levi; G. Lynch; L. M. Mir; P. J. Oddone; T. J. Orimoto; M. Pripstein; N. A. Roe; M. T. Ronan; V. G. Shelkov; A. V. Telnov; W. A. Wenzel; K. Ford; T. J. Harrison; C. M. Hawkes; S. E. Morgan; A. T. Watson; N. K. Watson; M. Fritsch; K. Goetzen; T. Held; H. Koch; B. Lewandowski; M. Pelizaeus; M. Steinke; J. T. Boyd; N. Chevalier; W. N. Cottingham; M. P. Kelly; T. E. Latham; F. F. Wilson; K. Abe; T. Cuhadar-Donszelmann; C. Hearty; T. S. Mattison; J. A. McKenna; D. Thiessen; P. Kyberd; L. Teodorescu; V. E. Blinov; A. D. Bukin; V. P. Druzhinin; V. B. Golubev; V. N. Ivanchenko; E. A. Kravchenko; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; A. N. Yushkov; D. Best; M. Bruinsma; M. Chao; I. Eschrich; D. Kirkby; A. J. Lankford; M. Mandelkern; R. K. Mommsen; W. Roethel; D. P. Stoker; C. Buchanan; B. L. Hartfiel; J. W. Gary; B. C. Shen; K. Wang; D. del Re; H. K. Hadavand; E. J. Hill; D. B. Macfarlane; H. P. Paar; Sh. Rahatlou; V. Sharma; J. W. Berryhill; C. Campagnari; B. Dahmes; S. L. Levy; O. Long; A. Lu; M. A. Mazur; J. D. Richman; W. Verkerke; T. W. Beck; A. M. Eisner; C. A. Heusch; W. S. Lockman; T. Schalk; R. E. Schmitz; B. A. Schumm; A. Seiden; P. Spradlin; D. C. Williams; M. G. Wilson; J. Albert; E. Chen; G. P. Dubois-Felsmann; A. Dvoretskii; D. G. Hitlin; I. Narsky; T. Piatenko; F. C. Porter; A. Ryd; A. Samuel; S. Yang; S. Jayatilleke; G. Mancinelli; B. T. Meadows; M. D. Sokoloff; T. Abe; F. Blanc; P. Bloom; S. Chen; P. J. Clark; W. T. Ford; U. Nauenberg; A. Olivas; P. Rankin; J. G. Smith; W. C. van Hoek; L. Zhang; J. L. Harton; T. Hu; A. Soffer; W. H. Toki; R. J. Wilson; D. Altenburg; T. Brandt; J. Brose; T. Colberg; M. Dickopp; E. Feltresi; A. Hauke; H. M. Lacker; E. Maly; R. Müller-Pfefferkorn; R. Nogowski; S. Otto; J. Schubert; K. R. Schubert; R. Schwierz; B. Spaan; D. Bernard; G. R. Bonneaud; F. Brochard; P. Grenier; Ch. Thiebaux; G. Vasileiadis; M. Verderi; D. J. Bard; A. Khan; D. Lavin; F. Muheim; S. Playfer; M. Andreotti; V. Azzolini; D. Bettoni; C. Bozzi; R. Calabrese; G. Cibinetto; E. Luppi; M. Negrini; A. Sarti; E. Treadwell; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; G. Finocchiaro; P. Patteri; M. Piccolo; A. Zallo; A. Buzzo; R. Capra; R. Contri; G. Crosetti; M. Lo Vetere; M. Macri; M. R. Monge; S. Passaggio; C. Patrignani; E. Robutti; A. Santroni; S. Tosi; S. Bailey; G. Brandenburg; M. Morii; E. Won; R. S. Dubitzky; U. Langenegger; W. Bhimji; D. A. Bowerman; P. D. Dauncey; U. Egede; J. R. Gaillard; G. W. Morton; J. A. Nash; G. P. Taylor; G. J. Grenier; S.-J. Lee; U. Mallik; J. Cochran; H. B. Crawley; J. Lamsa; W. T. Meyer; S. Prell; E. I. Rosenberg; J. Yi; M. Davier; G. Grosdidier; A. Höcker; S. Laplace; F. Le Diberder; V. Lepeltier; A. M. Lutz; T. C. Petersen; S. Plaszczynski; M. H. Schune; L. Tantot; G. Wormser; C. H. Cheng; D. J. Lange; M. C. Simani; D. M. Wright; A. J. Bevan; J. P. Coleman; J. R. Fry; E. Gabathuler; R. Gamet; M. Kay; R. J. Parry; D. J. Payne; R. J. Sloane; C. Touramanis; J. J. Back; P. F. Harrison; G. B. Mohanty; C. L. Brown; G. Cowan; R. L. Flack; H. U. Flaecher; S. George; M. G. Green; A. Kurup; C. E. Marker; T. R. McMahon; S. Ricciardi; F. Salvatore; G. Vaitsas; M. A. Winter; C. L. Davis; J. Allison; N. R. Barlow; R. J. Barlow; P. A. Hart; M. C. Hodgkinson; G. D. Lafferty; A. J. Lyon; J. C. Williams; A. Farbin; W. D. Hulsbergen; A. Jawahery; D. Kovalskyi; C. K. Lae; V. Lillard; D. A. Roberts; G. Blaylock; C. Dallapiccola; K. T. Flood; S. S. Hertzbach; R. Kofler; V. B. Koptchev; T. B. Moore; S. Saremi; H. Staengle; S. Willocq; R. Cowan; G. Sciolla; F. Taylor; R. K. Yamamoto; D. J. Mangeol; P. M. Patel; S. H. Robertson; A. Lazzaro; F. Palombo; J. M. Bauer; L. Cremaldi; V. Eschenburg; R. Godang; R. Kroeger; J. Reidy; D. A. Sanders; D. J. Summers; H. W. Zhao; S. Brunet; D. Côté; P. Taras; H. Nicholson; C. Cartaro; N. Cavallo; F. Fabozzi; C. Gatto; L. Lista; D. Monorchio; P. Paolucci; D. Piccolo; C. Sciacca; M. Baak; G. Raven; L. Wilden; C. P. Jessop; J. M. Losecco; T. A. Gabriel; T. Allmendinger; B. Brau; K. K. Gan; K. Honscheid; D. Hufnagel; H. Kagan; R. Kass; T. Pulliam; R. Ter-Antonyan; Q. K. Wong; J. Brau; R. Frey; O. Igonkina; C. T. Potter; N. B. Sinev; D. Strom; E. Torrence; F. Colecchia; A. Dorigo; F. Galeazzi; M. Margoni; M. Morandin; M. Posocco; M. Rotondo; F. Simonetto; R. Stroili; G. Tiozzo; C. Voci; M. Benayoun

    2004-01-01

    A search for the lepton-flavor-violating decay of the tau into three charged leptons has been performed using 91.5 fb-1 of data collected at an e+e-center-of-mass energy around 10.58 GeV with the BABAR detector at the SLAC storage ring PEP-II. In all six decay modes considered, the numbers of events found in data are compatible with the background expectations. Upper limits

  8. A precise measurement of the tau polarization and its forward-backward asymmetry at LEP

    Microsoft Academic Search

    Gideon Alexander; J. Allison; N. Altekamp; K A Ametewee; K. J. Anderson; S. Anderson; S. Arcelli; S. Asai; D A Axen; Georges Azuelos; A. H. Ball; E. Barberio; R. J. Barlow; R. Bartoldus; J Richard Batley; G. Beaudoin; J. Bechtluft; C. Beeston; T. Behnke; A. N. Bell; K. W. Bell; G. Bella; Stanislaus Cornelius Maria Bentvelsen; P. Berlich; Siegfried Bethke; O. Biebel; Volker Blobel; Ian J Bloodworth; J. E. Bloomer; P. Bock; H. M. Bosch; M. Boutemeur; B. T. Bouwens; S. Braibant; R. M. Brown; Helfried J Burckhart; C. Burgard; R. Bürgin; P. Capiluppi; R. K. Carnegie; A. A. Carter; J. R. Carter; C. Y. Chang; C. Charlesworth; D. G. Charlton; D. Chrisman; S. L. Chu; P. E. L. Clarke; I. Cohen; J. E. Conboy; O. C. Cooke; M. Cuffiani; S. Dado; C. Dallapiccola; G. M. Dallavalle; S. de Jong; L. A. Del Pozo; Klaus Desch; M. S. Dixit; E. Do Couto E Silva; M. Doucet; E. Duchovni; G. Duckeck; I. P. Duerdoth; J. E. G. Edwards; P. G. Estabrooks; H. G. Evans; M. Evans; Franco Luigi Fabbri; P. Fath; F. Fiedler; M. Fierro; H. M. Fischer; R. Folman; D. G. Fong; M. Foucher; H. Fukui; A. Fürtjes; P. Gagnon; A. Gaidot; J. W. Gary; J. Gascon; S. M. Gascon-Shotkin; N. I. Geddes; C. Geich-Gimbel; F. X. Gentit; T. Geralis; G. Giacomelli; P. Giacomelli; R. Giacomelli; V. Gibson; W. R. Gibson; D. M. Gingrich; J. Goldberg; M. J. Goodrick; W. Gorn; C. Grandi; E. Gross; M. Gruwé; C. Hajdu; G. G. Hanson; M. Hansroul; M. Hapke; C. K. Hargrove; P. A. Hart; C. Hartmann; M. Hauschild; C. M. Hawkes; R. Hawkings; Richard J Hemingway; G. Herten; R. D. Heuer; M. D. Hildreth; J. C. Hill; S. J. Hillier; T. Hilse; J. Hoare; P. R. Hobson; R. J. Homer; A. K. Honma; D. Horváth; R E Hughes-Jones; D. E. Hutchcroft; P. Igo-Kemenes; D. C. Imrie; M. R. Ingram; A. Jawahery; P. W. Jeffreys; H. Jeremie; M. Jimack; A. Joly; C. R. Jones; G. Jones; M. Jones; R. W. L. Jones; U. Jost; P. Jovanovic; T. R. Junk; D. Karlen; K. Kawagoe; T. Kawamoto; R G Kellogg; B. W. Kennedy; B. J. King; J. Kirk; S. Kluth; T. Kobayashi; M. Kobel; D. S. Koetke; T. P. Kokott; S. Komamiya; R. Kowalewski; T. Kress; P. Krieger; J. von Krogh; P. Kyberd; G. D. Lafferty; H. Lafoux; R. Lahmann; W. P. Lai; D. Lanske; J. Lauber; S. R. Lautenschlager; J. G. Layter; D. Lazic; A. M. Lee; E. Lefebvre; D. Lellouch; J. Letts; L. Levinson; C. Lewis; S. L. Lloyd; F. K. Loebinger; G. D. Long; M. J. Losty; J. Ludwig; A. Luig; A. Malik; M. Mannelli; S. Marcellini; C. Markus; A. J. Martin; J. P. Martin; G. Martinez; T. Mashimo; W. Matthews; P. Mättig; W. J. McDonald; J. McKenna; E. A. McKigney; T. J. McMahon; A. I. McNab; R. A. McPherson; F. Meijers; S. Menke; F. S. Merritt; H. Mes; J. Meyer; A. Michelini; G. Mikenberg; D. J. Miller; R. Mir; W. Mohr; A. Montanari; T. Mori; M. Morii; U. Müller; H. A. Neal; B Nijjhar; R. Nisius; S. W. O'Neale; F. G. Oakham; F. Odorici; H. O. Ogren; T. Omori; M. J. Oreglia; S. Orito; J. Pálinkás; J. P. Pansart; G. Pásztor; J. R. Pater; G. N. Patrick; M. J. Pearce; S. Petzold; P. Pfeifenschneider; J. E. Pilcher; J. Pinfold; D. E. Plane; P. Poffenberger; B. Poli; A. Posthaus; H. Przysiezniak; D. L. Rees; D. Rigby; S. A. Robins; N. Rodning; J. M. Roney; A. Rooke; E. Ros; A. M. Rossi; M. Rosvick; P. Routenburg; Y. Rozen; K. Runge; O. Runolfsson; U. Ruppel; D. R. Rust; R. Rylko; E. K. G. Sarkisyan; M. Sasaki; C. Sbarra; A. D. Schaile; O. Schaile; F. Scharf; P. Scharff-Hansen; P. Schenk; B. Schmitt; S. Schmitt; M. Schröder; H. C. Schultz-Coulon; M. Schulz; P. Schütz; W. G. Scott; T. G. Shears; B. C. Shen; C. H. Shepherd-Themistocleous; P. Sherwood; G. P. Siroli; A Skillman; A M Smith; T. J. Smith; G. A. Snow; R. Sobie; S. Söldner-Rembold; R. W. Springer; M. Sproston; A. Stahl; M Steiert; K. Stephens; J. Steuerer; B. Stockhausen; D. Strom; F. Strumia; P. Szymanski; R. Tafirout; S. D. Talbot; S. Tanaka; P. Taras; S. Tarem; M Thiergen; M. A. Thomson; E. von Törne; S. Towers; M. Tscheulin; T. Tsukamoto; E. Tsur; A. S. Turcot; M. F. Turner-Watson; P. Utzat; R. van Kooten; G. Vasseur; M. Verzocchi; P. Vikas; M. Vincter; E. H. Vokurka; F. Wäckerle; A. Wagner; C. P. Ward; D. R. Ward; J. J. Ward; P. M. Watkins; A. T. Watson; N. K. Watson; P S Wells; N. Wermes; J. S. White; B. Wilkens; G. W. Wilson; J. A. Wilson; T. Wlodek; G. Wolf; S. Wotton; T. R. Wyatt; S. Yamashita; G. Yekutieli; V. Zacek

    1996-01-01

    A measurement of the tau lepton polarization and its forward-backward asymmetry at the Z0 resonance using the OPAL detector is described. The measurement is based on analyses of tau-->rhonutau, tautaupi(K)nutau,tau to ebar nu _e nu _tau ,tau to mu bar nu _mu nu _tau and tau-->a1 nu tau decays from a sample of 89075 e+e---> tau + tau - candidates

  9. The Tau Lepton and the Search for New Elementary Particle Physics

    SciTech Connect

    Perl, Martin L.

    1998-11-18

    This Fifth International WEIN Symposium is devoted to physics beyond the standard model. This talk is about tau lepton physics, but I begin with the question: do we know how to find new physics in the world of elementary particles? This question is interwoven with the various tau physics topics. These topics are: searching for unexpected tau decay modes; searching for additional tau decay mechanisms; radiative tau decays; tau decay modes of the W, B, and D; decay of the Z{sup 0} to tau pairs; searching for CP violation in tau decay; the tau neutrino, dreams and odd ideas in tau physics; and tau research facilities in the next decades.

  10. Lifetime measurements and tau physics at PEP

    SciTech Connect

    Gladney, L.D.

    1984-05-01

    Recent updates on the measurements of the tau and D/sup 0/ lifetimes by the Mark II Collaboration and on measurements of the tau and B-hadron lifetimes by the MAC Collaboration are presented. A new determination of an upper limit for the tau neutrino mass by the Mark II Collaboration and a recent measurement of Cabibbo-suppressed tau decay branching ratios from the DELCO Collaboration are also presented. 18 references.

  11. Evidence for an excess of B to D(*) Tau Nu decays

    SciTech Connect

    Lees, J.P.; Poireau, V.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Palano, A.; /Bari U. /INFN, Bari; Eigen, G.; Stugu, B.; /Bergen U.; Brown, David Nathan; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; /LBL, Berkeley /UC, Berkeley; Koch, H.; Schroeder, T.; /Ruhr U., Bochum; Asgeirsson, D.J.; Hearty, C.; Mattison, T.S.; McKenna, J.A.; So, R.Y.; /British Columbia U.; Khan, A.; /Brunel U.; Blinov, V.E.; /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /Ferrara U. /INFN, Ferrara /Frascati /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U., Comp. Sci. Dept. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /Milan U. /INFN, Milan /Mississippi U. /Montreal U. /Naples U. /INFN, Naples /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U.; /more authors..

    2012-10-09

    Based on the full BABAR data sample, we report improved measurements of the ratios R(D{sup (*)}) = {Beta}({bar B} {yields} D{sup (*)} {tau}{sup -}{bar {nu}}{sub {tau}})/{Beta}({bar B} {yields} D{sup (*)} {ell}{sup -}{bar {nu}}{sub {ell}}), where {ell} is either e or {mu}. These ratios are sensitive to new physics contributions in the form of a charged Higgs boson. We measure R(D) = 0.440 {+-} 0.058 {+-} 0.042 and R(D*) = 0.332 {+-} 0.024 {+-} 0.018, which exceed the Standard Model expectations by 2.0{sigma} and 2.7{sigma}, respectively. Taken together, our results disagree with these expectations at the 3.4{sigma} level. This excess cannot be explained by a charged Higgs boson in the type II two-Higgs-doublet model. We also report the observation of the decay {bar B} {yields} D{tau}{sup -} {bar {nu}}{sub {tau}}, with a significance of 6.8{sigma}.

  12. Search for the decay tau--->3pi-2pi+2pi0nutau

    Microsoft Academic Search

    B. Aubert; R. Barate; M. Bona; D. Boutigny; F. Couderc; Y. Karyotakis; J. P. Lees; V. Poireau; V. Tisserand; A. Zghiche; E. Grauges; A. Palano; M. Pappagallo; J. C. Chen; N. D. Qi; G. Rong; P. Wang; Y. S. Zhu; G. Eigen; I. Ofte; B. Stugu; G. S. Abrams; M. Battaglia; D. N. Brown; J. Button-Shafer; R. N. Cahn; E. Charles; C. T. Day; M. S. Gill; Y. Groysman; R. G. Jacobsen; J. A. Kadyk; L. T. Kerth; Yu. G. Kolomensky; G. Kukartsev; G. Lynch; L. M. Mir; P. J. Oddone; T. J. Orimoto; M. Pripstein; N. A. Roe; M. T. Ronan; W. A. Wenzel; M. Barrett; K. E. Ford; T. J. Harrison; A. J. Hart; C. M. Hawkes; S. E. Morgan; A. T. Watson; K. Goetzen; T. Held; H. Koch; B. Lewandowski; M. Pelizaeus; K. Peters; T. Schroeder; M. Steinke; J. T. Boyd; J. P. Burke; W. N. Cottingham; D. Walker; T. Cuhadar-Donszelmann; B. G. Fulsom; C. Hearty; N. S. Knecht; T. S. Mattison; J. A. McKenna; A. Khan; P. Kyberd; M. Saleem; L. Teodorescu; V. E. Blinov; A. D. Bukin; V. P. Druzhinin; V. B. Golubev; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; K. Yu Todyshev; D. S. Best; M. Bondioli; M. Bruinsma; M. Chao; S. Curry; I. Eschrich; D. Kirkby; A. J. Lankford; P. Lund; M. Mandelkern; R. K. Mommsen; W. Roethel; D. P. Stoker; S. Abachi; C. Buchanan; S. D. Foulkes; J. W. Gary; O. Long; B. C. Shen; K. Wang; L. Zhang; H. K. Hadavand; E. J. Hill; H. P. Paar; S. Rahatlou; V. Sharma; J. W. Berryhill; C. Campagnari; A. Cunha; B. Dahmes; T. M. Hong; D. Kovalskyi; J. D. Richman; T. W. Beck; A. M. Eisner; C. J. Flacco; C. A. Heusch; J. Kroseberg; W. S. Lockman; G. Nesom; T. Schalk; B. A. Schumm; A. Seiden; P. Spradlin; D. C. Williams; M. G. Wilson; J. Albert; E. Chen; A. Dvoretskii; D. G. Hitlin; I. Narsky; T. Piatenko; F. C. Porter; A. Ryd; A. Samuel; R. Andreassen; G. Mancinelli; B. T. Meadows; M. D. Sokoloff; F. Blanc; P. C. Bloom; S. Chen; W. T. Ford; J. F. Hirschauer; A. Kreisel; U. Nauenberg; A. Olivas; W. O. Ruddick; J. G. Smith; K. A. Ulmer; S. R. Wagner; J. Zhang; A. Chen; E. A. Eckhart; A. Soffer; W. H. Toki; R. J. Wilson; F. Winklmeier; Q. Zeng; D. D. Altenburg; E. Feltresi; A. Hauke; H. Jasper; B. Spaan; T. Brandt; V. Klose; H. M. Lacker; W. F. Mader; R. Nogowski; A. Petzold; J. Schubert; K. R. Schubert; R. Schwierz; J. E. Sundermann; A. Volk; D. Bernard; G. R. Bonneaud; P. Grenier; E. Latour; Ch. Thiebaux; M. Verderi; D. J. Bard; P. J. Clark; W. Gradl; F. Muheim; S. Playfer; A. I. Robertson; Y. Xie; M. Andreotti; D. Bettoni; C. Bozzi; R. Calabrese; G. Cibinetto; E. Luppi; M. Negrini; A. Petrella; L. Piemontese; E. Prencipe; F. Anulli; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; G. Finocchiaro; S. Pacetti; P. Patteri; I. M. Peruzzi; M. Piccolo; M. Rama; A. Zallo; A. Buzzo; R. Capra; R. Contri; M. Lo Vetere; M. M. Macri; M. R. Monge; S. Passaggio; C. Patrignani; E. Robutti; A. Santroni; S. Tosi; G. Brandenburg; K. S. Chaisanguanthum; M. Morii; J. Wu; R. S. Dubitzky; J. Marks; S. Schenk; U. Uwer; W. Bhimji; D. A. Bowerman; P. D. Dauncey; U. Egede; R. L. Flack; J. R. Gaillard; J. A. Nash; M. B. Nikolich; W. Panduro Vazquez; X. Chai; M. J. Charles; U. Mallik; N. T. Meyer; V. Ziegler; J. Cochran; H. B. Crawley; L. Dong; V. Eyges; W. T. Meyer; S. Prell; E. I. Rosenberg; A. E. Rubin; A. V. Gritsan; M. Fritsch; G. Schott; N. Arnaud; M. Davier; G. Grosdidier; A. Höcker; F. Le Diberder; V. Lepeltier; A. M. Lutz; A. Oyanguren; S. Pruvot; S. Rodier; P. Roudeau; M. H. Schune; A. Stocchi; W. F. Wang; G. Wormser; C. H. Cheng; D. J. Lange; D. M. Wright; C. A. Chavez; I. J. Forster; J. R. Fry; E. Gabathuler; R. Gamet; K. A. George; D. E. Hutchcroft; D. J. Payne; K. C. Schofield; C. Touramanis; A. J. Bevan; F. Di Lodovico; W. Menges; R. Sacco; C. L. Brown; G. Cowan; H. U. Flaecher; D. A. Hopkins; P. S. Jackson; T. R. McMahon; S. Ricciardi; F. Salvatore; C. L. Davis; J. Allison; N. R. Barlow; R. J. Barlow; Y. M. Chia; C. L. Edgar; M. P. Kelly; G. D. Lafferty; M. T. Naisbit; J. C. Williams; J. I. Yi; C. Chen; W. D. Hulsbergen; A. Jawahery; C. K. Lae; D. A. Roberts; G. Simi; G. Blaylock; C. Dallapiccola; S. S. Hertzbach; X. Li; T. B. Moore; S. Saremi; H. Staengle; S. Y. Willocq; R. Cowan; K. Koeneke; G. Sciolla; S. J. Sekula; M. Spitznagel; F. Taylor; R. K. Yamamoto; H. Kim; P. M. Patel; C. T. Potter; S. H. Robertson; A. Lazzaro; V. Lombardo; F. Palombo; J. M. Bauer; L. Cremaldi; V. Eschenburg; R. Godang; R. Kroeger; J. Reidy; D. A. Sanders; D. J. Summers; H. W. Zhao; S. Brunet; D. Côté; M. Simard; P. Taras; F. B. Viaud; H. Nicholson; N. Cavallo; G. De Nardo; D. Del Re; F. Fabozzi; C. Gatto; L. Lista; D. Monorchio; P. Paolucci; D. Piccolo; C. Sciacca; M. Baak; H. Bulten; G. Raven; H. L. Snoek; C. P. Jessop; J. M. Losecco; T. Allmendinger; G. Benelli; K. K. Gan; K. Honscheid; D. Hufnagel; H. Kagan; R. Kass; T. Pulliam; A. M. Rahimi; R. Ter-Antonyan; Q. K. Wong; N. L. Blount; J. Brau; R. Frey

    2006-01-01

    A search for the decay of the tau lepton to five charged and two neutral pions is performed using data collected by the BABAR detector at the PEP-II asymmetric-energy e+e- collider. The analysis uses 232fb-1 of data at center-of-mass energies on or near the Upsilon(4S) resonance. We observe 10 events with an expected background of 6.5-1.4+2.0 events. In the absence

  13. Hadronic structure in the decay tau--->pi-pi0nutau

    Microsoft Academic Search

    S. Anderson; V. V. Frolov; Y. Kubota; S. J. Lee; R. Mahapatra; J. J. O'neill; R. Poling; T. Riehle; A. Smith; S. Ahmed; M. S. Alam; S. B. Athar; L. Jian; L. Ling; A. H. Mahmood; M. Saleem; S. Timm; F. Wappler; A. Anastassov; J. E. Duboscq; K. K. Gan; C. Gwon; T. Hart; K. Honscheid; H. Kagan; R. Kass; J. Lorenc; H. Schwarthoff; E. von Toerne; M. M. Zoeller; S. J. Richichi; H. Severini; P. Skubic; A. Undrus; M. Bishai; S. Chen; J. Fast; J. W. Hinson; J. Lee; N. Menon; D. H. Miller; E. I. Shibata; I. P. Shipsey; Y. Kwon; A. L. Lyon; E. H. Thorndike; C. P. Jessop; H. Marsiske; M. L. Perl; V. Savinov; D. Ugolini; X. Zhou; T. E. Coan; V. Fadeyev; I. Korolkov; Y. Maravin; I. Narsky; R. Stroynowski; J. Ye; T. Wlodek; M. Artuso; R. Ayad; E. Dambasuren; S. Kopp; G. Majumder; G. C. Moneti; S. Schuh; T. Skwarnicki; S. Stone; A. Titov; G. Viehhauser; J. C. Wang; A. Wolf; J. Wu; S. E. Csorna; K. W. McLean; S. Marka; Z. Xu; R. Godang; K. Kinoshita; I. C. Lai; S. Schrenk; G. Bonvicini; D. Cinabro; R. Greene; L. P. Perera; G. J. Zhou; S. Chan; G. Eigen; E. Lipeles; M. Schmidtler; A. Shapiro; W. M. Sun; J. Urheim; A. J. Weinstein; F. Würthwein; D. E. Jaffe; G. Masek; H. P. Paar; E. M. Potter; S. Prell; V. Sharma; D. M. Asner; A. Eppich; J. Gronberg; T. S. Hill; D. J. Lange; R. J. Morrison; T. K. Nelson; R. A. Briere; B. H. Behrens; W. T. Ford; A. Gritsan; H. Krieg; J. Roy; J. G. Smith; J. P. Alexander; R. Baker; C. Bebek; B. E. Berger; K. Berkelman; F. Blanc; V. Boisvert; D. G. Cassel; M. Dickson; P. S. Drell; K. M. Ecklund; R. Ehrlich; A. D. Foland; P. Gaidarev; R. S. Galik; L. Gibbons; B. Gittelman; S. W. Gray; D. L. Hartill; B. K. Heltsley; P. I. Hopman; C. D. Jones; D. L. Kreinick; T. Lee; Y. Liu; T. O. Meyer; N. B. Mistry; C. R. Ng; E. Nordberg; J. R. Patterson; D. Peterson; D. Riley; J. G. Thayer; P. G. Thies; B. Valant-Spaight; A. Warburton; P. Avery; M. Lohner; C. Prescott; A. I. Rubiera; J. Yelton; J. Zheng; G. Brandenburg; A. Ershov; Y. S. Gao; D. Y.-J. Kim; R. Wilson; T. E. Browder; Y. Li; J. L. Rodriguez; H. Yamamoto; T. Bergfeld; B. I. Eisenstein; J. Ernst; G. E. Gladding; G. D. Gollin; R. M. Hans; E. Johnson; I. Karliner; M. A. Marsh; M. Palmer; C. Plager; C. Sedlack; M. Selen; J. J. Thaler; J. Williams; K. W. Edwards; R. Janicek; P. M. Patel; A. J. Sadoff; R. Ammar; P. Baringer; A. Bean; D. Besson; R. Davis; S. Kotov; I. Kravchenko; N. Kwak; X. Zhao

    2000-01-01

    We report on a study of the invariant mass spectrum of the hadronic system in the decay tau--->pi-pi0nutau. This study was performed with data obtained with the CLEO II detector operating at the CESR e+e- collider. We present fits to phenomenological models in which resonance parameters associated with the rho(770) and rho(1450) mesons are determined. The pi-pi0 spectral function inferred

  14. Dispersive approach to QCD: tau lepton hadronic decay in vector and axial-vector channels

    E-print Network

    A. V. Nesterenko

    2014-09-02

    The dispersive approach to QCD, which extends the applicability range of perturbation theory towards the infrared domain, is developed. This approach properly accounts for the intrinsically nonperturbative constraints, which originate in the low-energy kinematic restrictions on pertinent strong interaction processes. The dispersive approach proves to be capable of describing OPAL (update 2012) and ALEPH (update 2014) experimental data on inclusive tau lepton hadronic decay in vector and axial-vector channels in a self-consistent way.

  15. Search for CP violation in tau and D decays with a K0S in the final state

    E-print Network

    Maurizio Martinelli

    2011-08-31

    I report the recent searches for CP violation in tau and D decays including a K0S in the final state. The analyses herein shown are based on data samples recorded by BaBar and Belle experiments. A brief introduction on CP violation is followed by the summary of the experimental techniques and the results obtained for tau and D decays, respectively. Finally, an outlook on future development is provided.

  16. Search for CP Violation in $\\tau$ And D Decays With a $K^0_S$ in the Final State

    SciTech Connect

    Martinelli, Maurizio; /Bari U. /INFN, Bari /SLAC

    2012-09-14

    I report the recent searches for CP violation in {tau} and D decays including a K{sub s}{sup 0} in the final state. The analyses herein shown are based on data samples recorded by BABAR and Belle experiments. A brief introduction on CP violation is followed by the summary of the experimental techniques and the results obtained for {tau} and D decays, respectively. Finally, an outlook on future development is provided.

  17. Measurement of the tau lifetime

    SciTech Connect

    Jaros, J.A.

    1982-10-01

    If the tau lepton couples to the charged weak current with universal strength, its lifetime can be expressed in terms of the muon's lifetime, the ratio of the masses of the muon and the tau, and the tau's branching ratio into e anti nu/sub e/ nu/sub tau/ as tau/sub tau/ = tau/sub ..mu../ (m/sub ..mu..//m/sub tau/)/sup 5/ B(tau ..-->.. e anti nu/sub e/nu/sub tau/) = 2.8 +- 0.2 x 10/sup -13/ s. This paper describes the measurement of the tau lifetime made by the Mark II collaboration, using a new high precision drift chamber in contunction with the Mark II detector at PEP. The results of other tau lifetime measurements are summarized.

  18. Selected Topics in Tau Physics from BaBar

    SciTech Connect

    Paramesvaran, S.; /Royal Holloway, U. of London; ,

    2012-04-06

    Selected results from {tau} analyses performed using the BABAR detector at the SLAC National Accelerator Laboratory are presented. A precise measurement of the {tau} mass and the {tau}{sup +}{tau}{sup -} mass difference is undertaken using the hadronic decay mode {tau}{sup {+-}} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup {+-}}{nu}{sub {tau}}. In addition an investigation into the strange decay modes {tau}{sup -} {yields} K{sub S}{sup 0}{pi}{sup -}{pi}{sup 0}{nu}{sub {tau}} and {tau}{sup -} {yields} K{sub S}{sup 0}{pi}{sup -}{nu}{sub {tau}} is also presented, including a fit to the {tau}{sup -} {yields} K{sub S}{sup 0}{pi}{sup -}{nu}{sub {tau}} invariant mass spectrum. Precise values for M(K*(892)) and {Lambda}(K*(892)) are obtained.

  19. Improved Limits on the Lepton Flavor Violating Decays Tau -> l V^0

    SciTech Connect

    Aubert, B.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Battaglia, M.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-06-19

    The authors search for the neutrinoless, lepton-flavor-violating tau decays {tau}{sup -} {yields} {ell}{sup -}V{sup 0}, where {ell} is an electron or muon and V{sup 0} is a fector meson reconstructed as {phi} {yields} K{sup +}K{sup -}, {rho} {yields} {pi}{sup +}{pi}{sup -}, K* {yields} K{sup +}{pi}{sup -}, {bar K}* {yields} K{sup -}{pi}{sup +}. The analysis has been performed using 451 fb{sup -1} of data collected at an e{sup +}e{sup -} center-of-mass energy near 10.58 GeV with the BABAR detector at the PEP-II storage rings. The number of events found in the data is compatible with the background expectation, and upper limits on the branching fractions are set in the range (2.6-19) x 10{sup -8} at the 90% confidence level.

  20. Measurements of Charged Current Lepton Universality and |Vus| using Tau Lepton Decays to e- v v, __- v v, pi- v and K- v

    SciTech Connect

    Aubert, Bernard; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Battaglia, M.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2011-06-30

    Using 467 fb{sup -1} of e{sup +}e{sup -} annihilation data collected with the BABAR detector, they measure {Beta}({tau}{sup -} {yields} {mu}{sup -}{bar {nu}}{sub {mu}}{nu}{sub {tau}})/{Beta}({tau}{sup -} {yields} e{sup -} {bar {nu}}{sub e}{nu}{sub {tau}}) = (0.9796 {+-} 0.0016 {+-} 0.0036), {Beta}({tau}{sup -} {yields} {pi}{sup -} {nu}{sub {tau}})/{Beta}({tau}{sup -} {yields} e{sup -}{bar {nu}}{sub e}{nu}{sub {tau}}) = (0.5945 {+-} 0.0014 {+-} 0.0061), and {Beta}({tau}{sup -} {yields} K{sup -}{nu}{sub {tau}})/{Beta}({tau}{sup -} {yields} e{sup -}{bar {nu}}{sub e}{nu}{sub {tau}}) = (0.03882 {+-} 0.00032 {+-} 0.00057), where the uncertainties are statistical and systematic, respectively. From these precision {tau} measurements, they test the Standard Model assumption of {mu}-e and {tau}-{mu} charge current lepton universality and provide determinations of |V{sub us}| experimentally independent of the decay of a kaon.

  1. Search for Lepton Flavor Violating $\\tau$- Decays into l-$\\eta, l-\\eta$' and l-$\\pi$0

    E-print Network

    Abe, K; Aihara, H; Anipko, D; Aoki, K; Arakawa, T; Arinstein, K; Asano, Y; Aso, T; Aulchenko, V M; Aushev, T; Aziz, T; Bahinipati, S; Bakich, A M; Balagura, V; Ban, Y; Banerjee, S; Barberio, E; Barbero, M; Bay, A; Bedny, I; Belous, K S; Bitenc, U; Bizjak, I; Blyth, S; Bondar, A; Bozek, A; Bracko, M; Brodzicka, J; Browder, T E; Chang, M C; Chang, P; Chao, Y; Chen, A; Chen, K F; Chen, W T; Cheon, B G; Chistov, R; Choi, J H; Choi, S K; Choi, Y; Choi, Y K; Chuvikov, A; Cole, S; Dalseno, J; Danilov, M; Dash, M; Dowd, R; Dragic, J; Drutskoy, A; Eidelman, S; Enari, Y; Epifanov, D A; Fratina, S; Fujii, H; Fujikawa, M; Gabyshev, N; Garmash, A; Gershon, T; Go, A; Gokhroo, G; Goldenzweig, P; Golob, B; Gorisek, A; Grosse-Perdekamp, M; Guler, H; Ha, H; Haba, J; Hara, K; Hara, T; Hasegawa, Y; Hastings, N C; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Higuchi, T; Hinz, L; Hokuue, T; Hoshi, Y; Hoshina, K; Hou, S; Hou, W S; Hsiung, Y B; Igarashi, Y; Iijima, T; Ikado, K; Imoto, A; Inami, K; Ishikawa, A; Ishino, H; Itoh, K; Itoh, R; Iwabuchi, M; Iwasaki, M; Iwasaki, Y; Jacoby, C; Jones, M; Kakuno, H; Kang, J H; Kang, J S; Kapusta, P; Kataoka, S U; Katayama, N; Kawai, H; Kawasaki, T; Khan, H R; Kibayashi, A; Kichimi, H; Kikuchi, N; Kim, H J; Kim, H O; Kim, J H; Kim, S K; Kim, T H; Kim, Y J; Kinoshita, K; Kishimoto, N; Korpar, S; Kozakai, Y; Krizan, P; Krokovnyi, P P; Kubota, T; Kulasiri, R; Kumar, R; Kuo, C C; Kurihara, E; Kusaka, A; Kuzmin, A; Kwon, Y J; Lange, J S; Leder, G; Lee, J; Lee, S E; Lee, Y J; Lesiak, T; Li, J; Limosani, A; Lin, C Y; Lin, S W; Liu, Y; Liventsev, D; MacNaughton, J; Majumder, G; Mandl, F; Marlow, D; Matsumoto, T; Matyja, A; McOnie, S; Medvedeva, T; Mikami, Y; Mitaroff, W A; Miyabayashi, K; Miyake, H; Miyata, H; Miyazaki, Y; Mizuk, R; Mohapatra, D; Moloney, G R; Mori, T; Müller, J; Murakami, A; Nagamine, T; Nagasaka, Y; Nakagawa, T; Nakahama, Y; Nakamura, I; Nakano, E; Nakao, M; Nakazawa, H; Natkaniec, Z; Neichi, K; Nishida, S; Nishimura, K; Nitoh, O; Noguchi, S; Nozaki, T; Ogawa, A; Ogawa, S; Ohshima, T; Okabe, T; Okuno, S; Olsen, S L; Ono, S; Ostrowicz, W; Ozaki, H; Pakhlov, P; Pakhlova, G; Palka, H; Park, C W; Park, H; Park, K S; Parslow, N; Peak, L S; Pernicka, M; Pestotnik, R; Peters, M; Piilonen, L E; Poluektov, A; Ronga, F J; Root, N; Rorie, J; Rózanska, M; Sahoo, H; Saitoh, S; Sakai, Y; Sakamoto, H; Sakaue, H; Sarangi, T R; Sato, N; Satoyama, N; Sayeed, K; Schietinger, T; Schneider, O; Schonmeier, P; Schümann, J; Schwanda, C; Schwartz, A J; Seidl, R; Seki, T; Senyo, K; Sevior, M E; Shapkin, M; Shen, Y T; Shibuya, H; Shwartz, B; Sidorov, V; Singh, J B; Sokolov, A; Somov, A; Soni, N; Stamen, R; Stanic, S; Staric, M; Stöck, H; Sugiyama, A; Sumisawa, K; Sumiyoshi, T; Suzuki, S; Suzuki, S Y; Tajima, O; Takada, N; Takasaki, F; Tamai, K; Tamura, N; Tanabe, K; Tanaka, M; Taylor, G N; Teramoto, Y; Tian, X C; Tikhomirov, I; Trabelsi, K; Tsai, Y T; Tse, Y F; Tsuboyama, T; Tsukamoto, T; Uchida, K; Uchida, Y; Uehara, S; Uglov, T; Ueno, K; Unno, Y; Uno, S; Urquijo, P; Ushiroda, Y; Usov, Yu; Varner, G; Varvell, K E; Villa, S; Wang, C C; Wang, C H; Wang, M Z; Watanabe, M; Watanabe, Y; Wicht, J; Widhalm, L; Wiechczynski, J; Won, E; Wu, C H; Xie, Q L; Yabsley, B D; Yamaguchi, A; Yamamoto, H; Yamamoto, S; Yamashita, Y; Yamauchi, M; Heyoung Yang; Yoshino, S; Yuan, Y; Yusa, Y; Zang, S L; Zhang, C C; Zhang, J; Zhang, L M; Zhang, Z P; Zhilich, V; Ziegler, T; Zupanc, A; Zürcher, D

    2007-01-01

    We have searched for lepton flavor violating $\\tau$ decays with a pseudoscalar meson ($\\eta$, $\\eta'$ and $\\pi^0$) using a data sample of 401 fb$^{-1}$ collected with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. No evidence for these decays is found and we set the following upper limits on the branching fractions: ${\\cal{B}}(\\tau^-\\to e^-\\eta) < 9.2\\times 10^{-8}$, ${\\cal{B}}(\\tau^-\\to \\mu^-\\eta) < 6.5\\times 10^{-8}$, ${\\cal{B}}(\\tau^-\\to e^-\\eta') < 1.6\\times 10^{-7}$, ${\\cal{B}}(\\tau^-\\to \\mu^-\\eta') < 1.3\\times 10^{-7}$ ${\\cal{B}}(\\tau^-\\to e^-\\pi^0) < 8.0\\times 10^{-8}$ and ${\\cal{B}}(\\tau^-\\to \\mu^-\\pi^0) < 1.2\\times 10^{-7}$ at the 90% confidence level, respectively. These results improve the previously published limits by factors from 2.3 to 6.4.

  2. Search for CP Violation in {tau}{sup {+-}}{yields}K{sub S}{sup 0}{pi}{sup {+-}}{nu}{sub {tau}} Decays at Belle

    SciTech Connect

    Bischofberger, M.; Hayashii, H.; Miyabayashi, K. [Nara Women's University, Nara (Japan); Adamczyk, K.; Bozek, A. [H. Niewodniczanski Institute of Nuclear Physics, Krakow (Poland); Aihara, H. [Department of Physics, University of Tokyo, Tokyo (Japan); Aulchenko, V.; Eidelman, S.; Epifanov, D.; Shwartz, B.; Vinokurova, A.; Zhulanov, V. [Budker Institute of Nuclear Physics, Novosibirsk (Russian Federation); Novosibirsk State University, Novosibirsk (Russian Federation); Bakich, A. M.; McOnie, S. [School of Physics, University of Sydney, NSW 2006 (Australia); Balagura, V.; Danilov, M.; Mizuk, R.; Pakhlova, G.; Uglov, T. [Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); Barberio, E. [University of Melbourne, School of Physics, Victoria 3010 (Australia)

    2011-09-23

    We report on a search for CP violation in {tau}{sup {+-}}{yields}K{sub S}{sup 0}{pi}{sup {+-}}{nu}{sub {tau}} decays using a data sample of 699 fb{sup -1} collected by the Belle experiment at the KEKB electron-positron asymmetric-energy collider. The CP asymmetry is measured in four bins of the invariant mass of the K{sub S}{sup 0}{pi}{sup {+-}} system and found to be compatible with zero with a precision of O(10{sup -3}) in each mass bin. Limits for the CP violation parameter Im({eta}{sub S}) are given at the 90% confidence level. These limits are |Im({eta}{sub S})|<0.026 or better, depending on the parametrization used to describe the hadronic form factors, and improve upon previous limits by 1 order of magnitude.

  3. New Results on the Hadronic Tau Decay Determination of ?s

    NASA Astrophysics Data System (ADS)

    Maltman, Kim

    2010-11-01

    Finite energy sum rule (FESR) analyses of non-strange hadronic ? decay data provide one of the most precise determinations of the strong coupling constant, ?s. Over the last two years, analyses of the relevant current-current two-point functions based on the recently derived 5-loop result for the relevant D=0 OPE contributions have reached a nominal precision of order 1%, and brought the resulting determination of ?s(MZ^2) into excellent agreement with independent lattice results. An outstanding issue for the FESR analyses is the possibility of residual ``duality violation'', i.e. of contributions associated with the breakdown of the OPE in the vicinity of the timelike real invariant-squared-mass axis. In this talk I discuss recent work to investigate and quantify these effects and present results for the impact of such contributions on the determination of ?s, as well as on the determination of the D=6 condensates appearing in the OPE representation of the non-strange vector minus axial vector correlator difference, which condensates are relevant to determining the chiral limit values of the K->?? matrix elements of the electroweak penguin operators in the Standard Model.The reported analysis also provides a new determination of the gluon condensate.

  4. A measurement of the \\/tau mass and the first CPT test with \\/tau leptons

    Microsoft Academic Search

    G. Abbiendi; K. Ackerstaff; C. Ainsley; P. F. Akesson; Gideon Alexander; J. Allison; K. J. Anderson; S. Arcelli; S. Asai; S. F. Ashby; D A Axen; Georges Azuelos; I. Bailey; A. H. Ball; E. Barberio; R. J. Barlow; J Richard Batley; S. Baumann; T. Behnke; K. W. Bell; G. Bella; A. Bellerive; Stanislaus Cornelius Maria Bentvelsen; Siegfried Bethke; O. Biebel; Ian J Bloodworth; P. Bock; J. Böhme; O. Boeriu; D. Bonacorsi; M. Boutemeur; S. Braibant; P G Bright-Thomas; L. Brigliadori; R. M. Brown; Helfried J Burckhart; J. Cammin; P. Capiluppi; R. K. Carnegie; A. A. Carter; J. R. Carter; C. Y. Chang; D. G. Charlton; C. Ciocca; P. E. L. Clarke; E. Clay; I. Cohen; O. C. Cooke; J. Couchman; C. Couyoumtzelis; R. L. Coxe; M. Cuffiani; S. Dado; G. M. Dallavalle; S. Dallison; R. Davis; A. de Roeck; P J Dervan; Klaus Desch; B. Dienes; M. S. Dixit; M. Donkers; J. Dubbert; E. Duchovni; G. Duckeck; I. P. Duerdoth; P. G. Estabrooks; E. Etzion; Franco Luigi Fabbri; M. Fanti; A. A. Faust; L. Feld; P. Ferrari; F. Fiedler; I. Fleck; M. Ford; A. Frey; A. Fürtjes; D. I. Futyan; P. Gagnon; J. W. Gary; G. Gaycken; C. Geich-Gimbel; G. Giacomelli; P. Giacomelli; D. M. Gingrich; D A Glenzinski; J. Goldberg; C. Grandi; K. Graham; E. Gross; Jacob Grunhaus; M. Gruwé; P. O. Günther; C. Hajdu; G. G. Hanson; M. Hansroul; M. Hapke; K. Harder; A. Harel; C. K. Hargrove; M. Harin-Dirac; A. Hauke; M. Hauschild; C. M. Hawkes; R. Hawkings; Richard J Hemingway; C. Hensel; G. Herten; R. D. Heuer; M. D. Hildreth; J. C. Hill; P. R. Hobson; A. Hocker; K. Hoffman; R James Homer; A. K. Honma; D. Horváth; K. R. Hossain; R. Howard; P. Hüntemeyer; P. Igo-Kemenes; D. C. Imrie; K. Ishii; F. R. Jacob; A. Jawahery; H. Jeremie; C. R. Jones; P. Jovanovic; T. R. Junk; N. Kanaya; J I Kanzaki; G V Karapetian; D A Karlen; V G Kartvelishvili; K. Kawagoe; T. Kawamoto; P. I. Kayal; Richard K Keeler; R. G. Kellogg; B. W. Kennedy; D. H. Kim; K. Klein; A. Klier; T. Kobayashi; M. Kobel; T. P. Kokott; S. Komamiya; R. V. Kowalewski; T. Kress; P. Krieger; J. von Krogh; T. Kuhl; M. Kupper; P. Kyberd; G. D. Lafferty; Hagar Yaël Landsman; D. Lanske; I. Lawson; J. G. Layter; A. Leins; Daniel Lellouch; J. Letts; L. Levinson; R. Liebisch; J. Lillich; B. List; C. Littlewood; A. W. Lloyd; S. L. Lloyd; F. K. Loebinger; G. D. Long; Michael J Losty; J. Lu; J. Ludwig; A. Macchiolo; A L MacPherson; W F Mader; M. Mannelli; S. Marcellini; T. E. Marchant; A. J. Martin; J. P. Martin; G. Martinez; T. Mashimo; P. Mättig; W. J. McDonald; J A McKenna; T. J. McMahon; R. A. McPherson; F. Meijers; P. Mendez-Lorenzo; F. S. Merritt; H. Mes; Aldo Michelini; S. Mihara; G. Mikenberg; D. J. Miller; W. Mohr; A. Montanari; T. Mori; K. Nagai; I. Nakamura; H. A. Neal; R. Nisius; S. W. O'Neale; F. G. Oakham; F. Odorici; H. O. Ogren; A. Oh; A N Okpara; M. J. Oreglia; S. Orito; G. Pásztor; J. R. Pater; G. N. Patrick; J. Patt; P. Pfeifenschneider; J. E. Pilcher; James L Pinfold; D. E. Plane; B. Poli; J. Polok; O. Pooth; M B Przybycien; A. Quadt; C. Rembser; Hartmut Rick; S. A. Robins; N L Rodning; J. M. Roney; S. Rosati; K. Roscoe; A. M. Rossi; Y. Rozen; K. Runge; O. Runolfsson; D. R. Rust; K. Sachs; T. Saeki; O. Sahr; W. M. Sang; E Sarkisyan-Grinbaum; C. Sbarra; A. D. Schaile; O. Schaile; P. Scharff-Hansen; S. Schmitt; M. Schröder; M. Schumacher; C. Schwick; W. G. Scott; R. Seuster; T. G. Shears; B. C. Shen; C. H. Shepherd-Themistocleous; P. Sherwood; G. P. Siroli; A. Skuja; A. M. Smith; G. A. Snow; Randall J Sobie; S. Söldner-Rembold; S. Spagnolo; M. Sproston; A. Stahl; K. Stephens; K. Stoll; D. Strom; R. Ströhmer; B. Surrow; S. D. Talbot; S. Tarem; R. J. Taylor; R. Teuscher; M. Thiergen; J. Thomas; M. A. Thomson; E. Torrence; S. Towers; T M Trefzger; I. Trigger; Z L Trócsányi; E. Tsur; M. F. Turner-Watson; I. Ueda; P. Vannerem; M. Verzocchi; H. Voss; Joost Herman Vossebeld; D. Waller; C. P. Ward; D. R. Ward; P. M. Watkins; A. T. Watson; N. K. Watson; P. S. Wells; T. Wengler; N. Wermes; D. Wetterling; J. S. White; G. W. Wilson; J. A. Wilson; T. R. Wyatt; S. Yamashita; V. Zacek; D. Zer-Zion

    2000-01-01

    We measure the mass of the \\/tau to be 1775.1+\\/-1.6(mcnstat.)+\\/- 1.0(mcnsys.) MeV using \\/tau from Z0 decays. To test CPT invariance we compare the masses of the positively and negatively charged \\/tau. The relative mass difference is found to be smaller than 3.0×10-3 at the 90% confidence level.

  5. Observation of $W\\rightarrow\\tau\

    E-print Network

    Mohammadi, Abdollah

    2011-01-01

    The production of W bosons decaying into a tau lepton and a neutrino with the tau lepton decaying hadronically has been observed in LHC pp collisions at $\\sqrt{s} = 7$~TeV with the CMS detector. The selection criteria provide a statistically significant signal

  6. U.Akgun, ECLIPSE06, Antalya, MSSM Higgs TauTau TauTau LeptonicLeptonic

    E-print Network

    Akgun, Ugur

    U.Akgun, ECLIPSE06, Antalya, Turkey MSSM Higgs TauTau TauTau LeptonicLeptonic Missing Et and Mass Reconstruction U. Akgun, F. Duru, S. Kunori The University of Iowa Fermilab #12;U.Akgun, ECLIPSE06, Antalya reconstruction improvements. #12;U.Akgun, ECLIPSE06, Antalya, Turkey bbA/H 2tau ll · We use DC04 sample. · Signal

  7. Search for Charged Higgs Boson Decays of the Top Quark using Hadronic Decays of the Tau Lepton

    Microsoft Academic Search

    F. Abe; H. Akimoto; A. Akopian; M. G. Albrow; S. R. Amendolia; D. Amidei; J. Antos; S. Aota; G. Apollinari; T. Asakawa; W. Ashmanskas; M. Atac; F. Azfar; P. Azzi-Bacchetta; N. Bacchetta; W. Badgett; S. Bagdasarov; M. W. Bailey; J. Berryhill; P. de Barbaro; A. Barbaro-Galtieri; V. E. Barnes; B. A. Barnett; M. Barone; E. Barzi; G. Bauer; T. Baumann; F. Bedeschi; S. Behrends; S. Belforte; G. Bellettini; J. Bellinger; D. Benjamin; J. Benlloch; J. Bensinger; D. Benton; A. Beretvas; J. P. Berge; S. Bertolucci; B. Bevensee; A. Bhatti; K. Biery; M. Binkley; D. Bisello; R. E. Blair; C. Blocker; A. Bodek; W. Bokhari; V. Bolognesi; G. Bolla; D. Bortoletto; J. Boudreau; L. Breccia; C. Bromberg; N. Bruner; E. Buckley-Geer; H. S. Budd; K. Burkett; G. Busetto; A. Byon-Wagner; K. L. Byrum; J. Cammerata; C. Campagnari; M. Campbell; A. Caner; W. Carithers; D. Carlsmith; A. Castro; D. Cauz; Y. Cen; F. Cervelli; P. S. Chang; H. Y. Chao; J. Chapman; M.-T. Cheng; G. Chiarelli; T. Chikamatsu; C. N. Chiou; L. Christofek; S. Cihangir; A. G. Clark; M. Cobal; E. Cocca; M. Contreras; J. Conway; J. Cooper; M. Cordelli; C. Couyoumtzelis; D. Cronin-Hennessy; R. Culbertson; T. Daniels; F. Dejongh; S. Delchamps; S. dell'Agnello; M. dell'Orso; R. Demina; L. Demortier; M. Deninno; P. F. Derwent; T. Devlin; J. R. Dittmann; S. Donati; J. Done; T. Dorigo; A. Dunn; N. Eddy; K. Einsweiler; J. E. Elias; R. Ely; E. Engels Jr.; D. Errede; S. Errede; Q. Fan; G. Feild; C. Ferretti; I. Fiori; B. Flaugher; G. W. Foster; M. Franklin; M. Frautschi; J. Freeman; J. Friedman; H. Frisch; Y. Fukui; S. Funaki; S. Galeotti; M. Gallinaro; O. Ganel; M. Garcia-Sciveres; A. F. Garfinkel; C. Gay; S. Geer; D. W. Gerdes; P. Giannetti; N. Giokaris; P. Giromini; G. Giusti; L. Gladney; D. Glenzinski; M. Gold; J. Gonzalez; A. Gordon; A. T. Goshaw; Y. Gotra; K. Goulianos; H. Grassmann; L. Groer; C. Grosso-Pilcher; G. Guillian; R. S. Guo; C. Haber; E. Hafen; S. R. Hahn; R. Handler; R. M. Hans; F. Happacher; K. Hara; A. D. Hardman; B. Harral; R. M. Harris; S. A. Hauger; J. Hauser; C. Hawk; E. Hayashi; J. Heinrich; B. Hinrichsen; K. D. Hoffman; M. Hohlmann; C. Holck; R. Hollebeek; L. Holloway; S. Hong; G. Houk; P. Hu; B. T. Huffman; R. Hughes; J. Huston; J. Huth; J. Hylen; H. Ikeda; M. Incagli; J. Incandela; G. Introzzi; J. Iwai; Y. Iwata; H. Jensen; U. Joshi; R. W. Kadel; E. Kajfasz; H. Kambara; T. A. Keaffaber; T. Kaneko; K. Karr; H. Kasha; Y. Kato; K. Kelley; R. D. Kennedy; R. Kephart; P. Kesten; D. Kestenbaum; H. Keutelian; F. Keyvan; B. Kharadia; B. J. Kim; D. H. Kim; H. S. Kim; S. B. Kim; S. H. Kim; Y. K. Kim; L. Kirsch; P. Koehn; K. Kondo; J. Konigsberg; S. Kopp; K. Kordas; A. Korytov; W. Koska; E. Kovacs; W. Kowald; M. Krasberg; J. Kroll; M. Kruse; T. Kuwabara; S. E. Kuhlmann; E. Kuns; A. T. Laasanen; S. Lami; S. Lammel; J. I. Lamoureux; M. Lancaster; T. Lecompte; S. Leone; J. D. Lewis; P. Limon; M. Lindgren; T. M. Liss; J. B. Liu; Y. C. Liu; N. Lockyer; O. Long; C. Loomis; M. Loreti; J. Lu; D. Lucchesi; P. Lukens; S. Lusin; J. Lys; K. Maeshima; A. Maghakian; P. Maksimovic; M. Mangano; J. Mansour; M. Mariotti; J. P. Marriner; A. Martin; J. A. Matthews; R. Mattingly; P. McIntyre; P. Melese; A. Menzione; E. Meschi; S. Metzler; C. Miao; T. Miao; G. Michail; R. Miller; H. Minato; S. Miscetti; M. Mishina; H. Mitsushio; T. Miyamoto; S. Miyashita; N. Moggi; Y. Morita; A. Mukherjee; T. Muller; P. Murat; H. Nakada; I. Nakano; C. Nelson; D. Neuberger; C. Newman-Holmes; C.-Y. P. Ngan; M. Ninomiya; L. Nodulman; S. H. Oh; K. E. Ohl; T. Ohmoto; T. Ohsugi; R. Oishi; M. Okabe; T. Okusawa; R. Oliveira; J. Olsen; C. Pagliarone; R. Paoletti; V. Papadimitriou; S. P. Pappas; N. Parashar; A. Parri; J. Patrick; G. Pauletta; M. Paulini; A. Perazzo; L. Pescara; M. D. Peters; T. J. Phillips; G. Piacentino; M. Pillai; K. T. Pitts; R. Plunkett; L. Pondrom; J. Proudfoot; F. Ptohos; G. Punzi; K. Ragan; D. Reher; A. Ribon; F. Rimondi; L. Ristori; W. J. Robertson; T. Rodrigo; S. Rolli; J. Romano; L. Rosenson; R. Roser; T. Saab; W. K. Sakumoto; D. Saltzberg; A. Sansoni; L. Santi; H. Sato; P. Schlabach; E. E. Schmidt; M. P. Schmidt; A. Scribano; S. Segler; S. Seidel; Y. Seiya; G. Sganos; M. D. Shapiro; N. M. Shaw; Q. Shen; P. F. Shepard; M. Shimojima; M. Shochet; J. Siegrist; A. Sill; P. Sinervo; P. Singh; J. Skarha; K. Sliwa; F. D. Snider; T. Song; J. Spalding; T. Speer; P. Sphicas; F. Spinella; M. Spiropulu; L. Spiegel; L. Stanco; J. Steele; A. Stefanini; K. Strahl; J. Strait; R. Ströhmer; D. Stuart; G. Sullivan; K. Sumorok; J. Suzuki; T. Takada; T. Takahashi; T. Takano; K. Takikawa; N. Tamura; B. Tannenbaum; F. Tartarelli; W. Taylor; P. K. Teng; Y. Teramoto; S. Tether; D. Theriot; T. L. Thomas; R. Thun; R. Thurman-Keup; M. Timko; P. Tipton; A. Titov; S. Tkaczyk; D. Toback; K. Tollefson; A. Tollestrup; H. Toyoda; W. Trischuk; J. F. de Troconiz; S. Truitt; J. Tseng; N. Turini; T. Uchida

    1997-01-01

    This Letter describes a direct search for charged Higgs boson production in pp¯ collisions at s = 1.8 TeV recorded by the Collider Detector at Fermilab. Two-Higgs-double extensions to the standard model predict the existence of charged Higgs bosons \\\\(H+\\/-\\\\). In such models, the branching fraction for top quarks B\\\\(t-->H+b-->tau+nub\\\\) can be large. This search uses the hadronic decays of

  8. Measurements of the tau Mass and Mass Difference of the tau^+ and tau^- at BABAR

    SciTech Connect

    Aubert, B.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Battaglia, M.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-10-30

    The authors present the result of a precision measurement of the mass of the {tau} lepton, M{sub {tau}}, based on 423 fb{sup -1} of data recorded at the {Upsilon}(4S) resonance with the BABAR detector. Using a pseudomass endpoint method, they determine the mass to be 1776.68 {+-} 0.12(stat) {+-} 0.41(syst) MeV. They also measure the mass difference between the {tau}{sup +} and {tau}{sup -}, and obtain (M{sub {tau}{sup +}} - M{sub {tau}{sup -}})/M{sub AVG}{sup {tau}} = (-3.4 {+-} 1.3(stat) {+-} 0.3(syst)) x 10{sup -4}, where M{sub AVG}{sup {tau}} is the average value of M{sub {tau}{sup +}} and M{sub {tau}{sup -}}.

  9. Search for Lepton Flavour Violating Decays Tau- to L- K0(S) and Tau- to L- (Rho0, K*0, Anti-K*0, Phi) at BaBar

    SciTech Connect

    Cenci, R.; /SLAC; Roney, J.M.; /Victoria U.

    2011-11-30

    We report on recent searches for lepton flavour violating decays of the {tau} lepton: {tau}{sup -} {yields} {ell}{sup -} K{sub S}{sup 0}, {tau}{sup -} {yields} {ell}{sup -}({rho}{sup 0}, K*{sup 0}, {bar K}*{sup 0}, {phi}). These preliminary results use data samples collected by the BaBar detector at the SLAC PEP-II B factory corresponding to integrated luminosities of 469 fb{sup -1} for the {tau}{sup -} {yields} {ell}{sup -}K{sub S}{sup 0} and 451 fb{sup -1} for the {tau}{sup -} {yields} {ell}{sup -}({rho}{sup 0}, K*{sup 0}, {bar K}*{sup 0}, {phi}) searches. No statistically significant signal has been observed in any of these channels and we set upper limits on their branching fractions between 0.8-18.2 x 10{sup -8} at 90% confidence level.

  10. Search for a low mass Standard Model Higgs boson in the tau-tau decay channel in $p\\bar{p}$ collisions at $\\sqrt{s}$ = 1.96 TeV

    E-print Network

    CDF Collaboration; T. Aaltonen; B. Alvarez Gonzalez; S. Amerio; D. Amidei; A. Anastassov; A. Annovi; J. Antos; G. Apollinari; J. A. Appel; A. Apresyan; T. Arisawa; A. Artikov; J. Asaadi; W. Ashmanskas; B. Auerbach; A. Aurisano; F. Azfar; W. Badgett; A. Barbaro-Galtieri; V. E. Barnes; B. A. Barnett; P. Barria; P. Bartos; M. Bauce; G. Bauer; F. Bedeschi; D. Beecher; S. Behari; G. Bellettini; J. Bellinger; D. Benjamin; A. Beretvas; A. Bhatti; M. Binkley; D. Bisello; I. Bizjak; K. R. Bland; B. Blumenfeld; A. Bocci; A. Bodek; D. Bortoletto; J. Boudreau; A. Boveia; L. Brigliadori; A. Brisuda; C. Bromberg; E. Brucken; M. Bucciantonio; J. Budagov; H. S. Budd; S. Budd; K. Burkett; G. Busetto; P. Bussey; A. Buzatu; C. Calancha; S. Camarda; M. Campanelli; M. Campbell; F. Canelli; A. Canepa; B. Carls; D. Carlsmith; R. Carosi; S. Carrillo; S. Carron; B. Casal; M. Casarsa; A. Castro; P. Catastini; D. Cauz; V. Cavaliere; M. Cavalli-Sforza; A. Cerri; L. Cerrito; Y. C. Chen; M. Chertok; G. Chiarelli; G. Chlachidze; F. Chlebana; K. Cho; D. Chokheli; J. P. Chou; W. H. Chung; Y. S. Chung; C. I. Ciobanu; M. A. Ciocci; A. Clark; C. Clarke; G. Compostella; M. E. Convery; J. Conway; M. Corbo; M. Cordelli; C. A. Cox; D. J. Cox; F. Crescioli; C. Cuenca Almenar; J. Cuevas; R. Culbertson; D. Dagenhart; N. d'Ascenzo; M. Datta; P. de Barbaro; S. De Cecco; G. De Lorenzo; M. Dell'Orso; C. Deluca; L. Demortier; J. Deng; M. Deninno; F. Devoto; M. d'Errico; A. Di Canto; B. Di Ruzza; J. R. Dittmann; M. D'Onofrio; S. Donati; P. Dong; M. Dorigo; T. Dorigo; K. Ebina; A. Elagin; A. Eppig; R. Erbacher; D. Errede; S. Errede; N. Ershaidat; R. Eusebi; H. C. Fang; S. Farrington; M. Feindt; J. P. Fernandez; C. Ferrazza; R. Field; G. Flanagan; R. Forrest; M. J. Frank; M. Franklin; J. C. Freeman; Y. Funakoshi; I. Furic; M. Gallinaro; J. Galyardt; J. E. Garcia; A. F. Garfinkel; P. Garosi; H. Gerberich; E. Gerchtein; S. Giagu; V. Giakoumopoulou; P. Giannetti; K. Gibson; C. M. Ginsburg; N. Giokaris; P. Giromini; M. Giunta; G. Giurgiu; V. Glagolev; D. Glenzinski; M. Gold; D. Goldin; N. Goldschmidt; A. Golossanov; G. Gomez; G. Gomez-Ceballos; M. Goncharov; O. Gonzalez; I. Gorelov; A. T. Goshaw; K. Goulianos; S. Grinstein; C. Grosso-Pilcher; R. C. Group; J. Guimaraes da Costa; Z. Gunay-Unalan; C. Haber; S. R. Hahn; E. Halkiadakis; A. Hamaguchi; J. Y. Han; F. Happacher; K. Hara; D. Hare; M. Hare; R. F. Harr; K. Hatakeyama; C. Hays; M. Heck; J. Heinrich; M. Herndon; S. Hewamanage; D. Hidas; A. Hocker; W. Hopkins; D. Horn; S. Hou; R. E. Hughes; M. Hurwitz; U. Husemann; N. Hussain; M. Hussein; J. Huston; G. Introzzi; M. Iori; A. Ivanov; E. James; D. Jang; B. Jayatilaka; E. J. Jeon; M. K. Jha; S. Jindariani; W. Johnson; M. Jones; K. K. Joo; S. Y. Jun; T. R. Junk; T. Kamon; P. E. Karchin; A. Kasmi; Y. Kato; W. Ketchum; J. Keung; V. Khotilovich; B. Kilminster; D. H. Kim; H. S. Kim; H. W. Kim; J. E. Kim; M. J. Kim; S. B. Kim; S. H. Kim; Y. K. Kim; N. Kimura; M. Kirby; S. Klimenko; K. Kondo; D. J. Kong; J. Konigsberg; A. V. Kotwal; M. Kreps; J. Kroll; D. Krop; N. Krumnack; M. Kruse; V. Krutelyov; T. Kuhr; M. Kurata; S. Kwang; A. T. Laasanen; S. Lami; S. Lammel; M. Lancaster; R. L. Lander; K. Lannon; A. Lath; G. Latino; T. LeCompte; E. Lee; H. S. Lee; J. S. Lee; S. W. Lee; S. Leo; S. Leone; J. D. Lewis; A. Limosani; C. -J. Lin; J. Linacre; M. Lindgren; E. Lipeles; A. Lister; D. O. Litvintsev; C. Liu; Q. Liu; T. Liu; S. Lockwitz; A. Loginov; D. Lucchesi; J. Lueck; P. Lujan; P. Lukens; G. Lungu; J. Lys; R. Lysak; R. Madrak; K. Maeshima; K. Makhoul; S. Malik; G. Manca; A. Manousakis-Katsikakis; F. Margaroli; C. Marino; M. Martinez; R. Martinez-Ballarin; P. Mastrandrea; M. E. Mattson; P. Mazzanti; K. S. McFarland; P. McIntyre; R. McNulty; A. Mehta; P. Mehtala; A. Menzione; C. Mesropian; T. Miao; D. Mietlicki; A. Mitra; H. Miyake; S. Moed; N. Moggi; M. N. Mondragon; C. S. Moon; R. Moore; M. J. Morello; J. Morlock; P. Movilla Fernandez; A. Mukherjee; Th. Muller; P. Murat; M. Mussini; J. Nachtman; Y. Nagai; J. Naganoma; I. Nakano; A. Napier; J. Nett; C. Neu; M. S. Neubauer; J. Nielsen; L. Nodulman; O. Norniella; E. Nurse; L. Oakes; S. H. Oh; Y. D. Oh; I. Oksuzian; T. Okusawa; R. Orava; L. Ortolan; S. Pagan Griso; C. Pagliarone; E. Palencia; V. Papadimitriou; A. A. Paramonov; J. Patrick; G. Pauletta; M. Paulini; C. Paus; D. E. Pellett; A. Penzo; T. J. Phillips; G. Piacentino; E. Pianori; J. Pilot; K. Pitts; C. Plager; L. Pondrom; S. Poprocki; K. Potamianos; O. Poukhov; F. Prokoshin; A. Pronko; F. Ptohos; E. Pueschel; G. Punzi; J. Pursley; A. Rahaman; V. Ramakrishnan; N. Ranjan; J. Ray; I. Redondo; P. Renton; M. Rescigno; T. Riddick; F. Rimondi; L. Ristori; A. Robson; T. Rodrigo; T. Rodriguez; E. Rogers; S. Rolli; R. Roser; M. Rossi; F. Rubbo; F. Ruffini; A. Ruiz; J. Russ; V. Rusu; A. Safonov; W. K. Sakumoto; Y. Sakurai; L. Santi; L. Sartori; K. Sato; V. Saveliev

    2012-01-23

    We report on a search for the standard model Higgs boson decaying into pairs of tau leptons in $p\\bar{p}$ collisions produced by the Tevatron at $\\sqrt{s}$ = 1.96 TeV. The analyzed data sample was recorded by the CDFII detector and corresponds to an integrated luminosity of 6.0 fb$^{-1}$. The search is performed in the final state with one tau decaying leptonically and the second one identified through its semi-hadronic decay.Since no significant excess is observed, a 95% credibility level upper limit on the production cross section times branching ratio to the tau-tau final state is set for hypothetical Higgs boson masses between 100 and 150 GeV/$c^2$. For a Higgs boson of 120 GeV/$c^2$ the observed (expected) limit is 14.6 (15.3) the predicted value.

  11. The Search for B+ to Tau+ Nu(Tau) at BaBar

    SciTech Connect

    Corwin, L.A.; /SLAC

    2007-01-08

    We present a search for the decay B{sup +} {yields} {tau}{sup +}{nu}{sub {tau}} using 288 fb{sup -1} of data collected at the {Upsilon}(4S) resonance with the BABAR detector at the SLAC PEP-II B-Factory. A sample of events with one reconstructed semileptonic B decay (B{sup -} {yields} D{sup o}{ell}{sup -}{bar {nu}}{sub {ell}}X) is selected, and in the recoil a search for B{sup +} {yields} {tau}{sup +}{nu}{sub {tau}} signal is performed. The {tau} is identified in the following channels: {tau}{sup +} {yields} e{sup +}{nu}{sub e}{bar {nu}}{sub {tau}}, {tau}{sup +} {yields} {mu}{sup +} {nu}{sub {mu}}{bar {nu}}{sub {tau}}, {tau}{sup +} {yields} {pi}{sup +}{pi}{sup 0}{bar {nu}}{sub {tau}}. We measure a branching fraction of {Beta}(B{sup +} {yields} {tau}{sup +}{nu}{sub {tau}}) = 0.88{sub -0.67}{sup +0.68}(stat.) {+-} 0.11(syst.) x 10{sup -4} and extract an upper limit on the branching fraction, at the 90% confidence level, of {Beta}(B{sup +} {yields} {tau}{sup +}{nu}{sub {tau}}) < 1.8 x 10{sup -4}. We calculate the product of the B meson decay constant and |V{sub ub}| to be f{sub B} {center_dot} |V{sub ub}| = (7.0{sub -3.6}{sup +2.3}(stat.){sub -0.5}{sup +0.4}(syst.)) x 10{sup -4} GeV.

  12. Search for neutral MSSM Higgs bosons decaying to a pair of tau leptons in pp collisions

    SciTech Connect

    Khachatryan, V. [Yerevan Physics Institute (Armenia); et al.,

    2014-10-01

    A search for neutral Higgs bosons in the minimal supersymmetric extension of the standard model (MSSM) decaying to tau-lepton pairs in pp collisions is performed, using events recorded by the CMS experiment at the LHC. The dataset corresponds to an integrated luminosity of 24.6 fb?¹, with 4.9 fb?¹ at 7 TeV and 19.7 fb?¹ at 8 TeV. To enhance the sensitivity to neutral MSSM Higgs bosons, the search includes the case where the Higgs boson is produced in association with a b-quark jet. No excess is observed in the tau-lepton-pair invariant mass spectrum. Exclusion limits are presented in the MSSM parameter space for different benchmark scenarios, mhmax, mhmod+ , mhmod– , light-stop, light-stau, ?-phobic, and low-mH. Upper limits on the cross section times branching fraction for gluon fusion and b-quark associated Higgs boson production are also given.

  13. Search for neutral MSSM Higgs bosons decaying to a pair of tau leptons in pp collisions

    NASA Astrophysics Data System (ADS)

    Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Dragicevic, M.; Erö, J.; Fabjan, C.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Kiesenhofer, W.; Knünz, V.; Krammer, M.; Krätschmer, I.; Liko, D.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schöfbeck, R.; Strauss, J.; Taurok, A.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; Bansal, M.; Bansal, S.; Cornelis, T.; De Wolf, E. A.; Janssen, X.; Knutsson, A.; Luyckx, S.; Ochesanu, S.; Rougny, R.; Van De Klundert, M.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Blekman, F.; Blyweert, S.; D'Hondt, J.; Daci, N.; Heracleous, N.; Keaveney, J.; Lowette, S.; Maes, M.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Onsem, G. P.; Villella, I.; Caillol, C.; Clerbaux, B.; De Lentdecker, G.; Dobur, D.; Favart, L.; Gay, A. P. R.; Grebenyuk, A.; Léonard, A.; Mohammadi, A.; Perniè, L.; Reis, T.; Seva, T.; Thomas, L.; Vander Velde, C.; Vanlaer, P.; Wang, J.; Zenoni, F.; Adler, V.; Beernaert, K.; Benucci, L.; Cimmino, A.; Costantini, S.; Crucy, S.; Dildick, S.; Fagot, A.; Garcia, G.; Mccartin, J.; Ocampo Rios, A. A.; Ryckbosch, D.; Salva Diblen, S.; Sigamani, M.; Strobbe, N.; Thyssen, F.; Tytgat, M.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Beluffi, C.; Bruno, G.; Castello, R.; Caudron, A.; Ceard, L.; Da Silveira, G. G.; Delaere, C.; du Pree, T.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Jafari, A.; Jez, P.; Komm, M.; Lemaitre, V.; Nuttens, C.; Pagano, D.; Perrini, L.; Pin, A.; Piotrzkowski, K.; Popov, A.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Vizan Garcia, J. M.; Beliy, N.; Caebergs, T.; Daubie, E.; Hammad, G. H.; Aldá, W. L.; Alves, G. A.; Brito, L.; Correa Martins, M.; Dos Reis Martins, T.; Mora Herrera, C.; Pol, M. E.; Carvalho, W.; Chinellato, J.; Custódio, A.; Da Costa, E. M.; De Jesus Damiao, D.; De Oliveira Martins, C.; Fonseca De Souza, S.; Malbouisson, H.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Prado Da Silva, W. L.; Santaolalla, J.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Bernardes, C. A.; Dogra, S.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Novaes, S. F.; Padula, Sandra S.; Aleksandrov, A.; Genchev, V.; Iaydjiev, P.; Marinov, A.; Piperov, S.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Tcholakov, V.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Hadjiiska, R.; Kozhuharov, V.; Litov, L.; Pavlov, B.; Petkov, P.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Du, R.; Jiang, C. H.; Plestina, R.; Tao, J.; Wang, Z.; Asawatangtrakuldee, C.; Ban, Y.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Zou, W.; Avila, C.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; Gomez Moreno, B.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Polic, D.; Puljak, I.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Kadija, K.; Luetic, J.; Mekterovic, D.; Sudic, L.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Bodlak, M.; Finger, M.; Finger, M.; Assran, Y.; Ellithi Kamel, A.; Mahmoud, M. A.; Radi, A.; Kadastik, M.; Murumaa, M.; Raidal, M.; Tiko, A.; Eerola, P.; Fedi, G.; Voutilainen, M.; Härkönen, J.; Karimäki, V.; Kinnunen, R.; Kortelainen, M. J.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Locci, E.; Malcles, J.; Rander, J.; Rosowsky, A.; Titov, M.; Baffioni, S.; Beaudette, F.; Busson, P.; Charlot, C.; Dahms, T.; Dalchenko, M.; Dobrzynski, L.; Filipovic, N.; Florent, A.; Granier de Cassagnac, R.; Mastrolorenzo, L.; Miné, P.; Mironov, C.; Naranjo, I. N.; Nguyen, M.; Ochando, C.; Paganini, P.; Regnard, S.; Salerno, R.; Sauvan, J. B.; Sirois, Y.; Veelken, C.; Yilmaz, Y.; Zabi, A.; Agram, J.-L.; Andrea, J.; Aubin, A.; Bloch, D.; Brom, J.-M.; Chabert, E. C.; Collard, C.; Conte, E.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Goetzmann, C.; Le Bihan, A.-C.; Van Hove, P.; Gadrat, S.; Beauceron, S.; Beaupere, N.; Boudoul, G.; Bouvier, E.; Brochet, S.; Carrillo Montoya, C. A.; Chasserat, J.; Chierici, R.; Contardo, D.; Depasse, P.; El Mamouni, H.; Fan, J.; Fay, J.; Gascon, S.; Gouzevitch, M.; Ille, B.; Kurca, T.; Lethuillier, M.; Mirabito, L.; Perries, S.; Ruiz Alvarez, J. D.; Sabes, D.; Sgandurra, L.; Sordini, V.; Vander Donckt, M.; Verdier, P.; Viret, S.; Xiao, H.; Tsamalaidze, Z.; Autermann, C.; Beranek, S.

    2014-10-01

    A search for neutral Higgs bosons in the minimal supersymmetric extension of the standard model (MSSM) decaying to tau-lepton pairs in pp collisions is performed, using events recorded by the CMS experiment at the LHC. The dataset corresponds to an integrated luminosity of 24.6 fb-1, with 4.9 fb-1 at 7 TeV and 19.7 fb-1 at 8 TeV. To enhance the sensitivity to neutral MSSM Higgs bosons, the search includes the case where the Higgs boson is produced in association with a b-quark jet. No excess is observed in the tau-lepton-pair invariant mass spectrum. Exclusion limits are presented in the MSSM parameter space for different benchmark scenarios, m {h/max}, m {h/mod +}, m {h/mod -}, light-stop, light-stau, ?-phobic, and low- m H. Upper limits on the cross section times branching fraction for gluon fusion and b-quark associated Higgs boson production are also given. [Figure not available: see fulltext.

  14. The physics of the tau lepton

    Microsoft Academic Search

    B. C. Barish; R. Stroynowski

    1988-01-01

    A comprehensive review of the status of tau-lepton physics is presented. We include the knowledge on the properties of the tau, the decay branching fractions and tests of the standard model. Discussions of possible puzzles and an indication of the future possibilities in this field are a lso presented.

  15. Search for Second-Class Currents in tau- -> omega.pi-.nu_tau

    E-print Network

    The BABAR Collaboration; B. Aubert

    2009-04-20

    We report an analysis of tau- decaying into omega.pi-.nu_tau with omega -> pi+pi-pi0 using a data sample containing nearly 320 million tau pairs collected with the BABAR detector at the PEP-II B-Factory. We find no evidence for second-class currents and we set an upper limit of 0.69% at 90% confidence level for the fraction of second-class currents in this decay mode.

  16. Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation

    PubMed Central

    Huang, Yunpeng; Wu, Zhihao; Cao, Yu; Lang, Minglin; Lu, Bingwei; Zhou, Bing

    2015-01-01

    SUMMARY Tau hyperphosphorylation is thought to underlie tauopathy. Working in a Drosophila tauopathy model expressing a human Tau mutant (hTauR406W, or Tau*), we show that zinc contributes to the development of Tau toxicity through two independent actions: by increasing Tau phosphorylation and, more significantly, by directly binding to Tau. Elimination of zinc binding through amino acid substitution of Cys residues has a minimal effect on phosphorylation levels yet essentially eliminates Tau toxicity. The toxicity of the zinc-binding-deficient mutant Tau* (Tau*C2A) and overexpression of native Drosophila Tau, also lacking the corresponding zinc-binding Cys residues, are largely impervious to zinc concentration. Importantly, restoration of zinc-binding ability to Tau* by introduction of a zinc-binding residue (His) into the original Cys positions restores zinc-responsive toxicities in proportion to zinc-binding affinities. These results indicate zinc binding is a substantial contributor to tauopathy and have implications for therapy development. PMID:25066125

  17. A measurement of the tau lifetime

    Microsoft Academic Search

    P. Abreu; W. Adam; T. Adye; E. Agasi; R. Aleksan; G. D. Alekseev; A. Algeri; P. Allen; S. Almehed; S. J. Alvsvaag; U. Amaldi; E. G. Anassontzis; A. Andreazza; P. Antilogus; W.-D. Apel; R. J. Apsimon; Y. Arnoud; B. Å; J.-E. Augustin; A. Augustinus; P. Baillon; P. Bambade; F. Barao; R. Barate; G. Barbiellini; D. Y. Bardin; G. J. Barker; A. Baroncelli; O. Barring; J. A. Barrio; W. Bartl; M. J. Bates; M. Battaglia; M. Baubillier; K.-H. Becks; C. J. Beeston; M. Begalli; P. Beilliere; Yu. Belokopytov; P. Beltran; D. Benedic; A. C. Benvenuti; M. Berggren; D. Bertrand; F. Bianchi; M. S. Bilenky; P. Billoir; J. Bjarne; D. Bloch; S. Blyth; V. Bocci; P. N. Bogolubov; T. Bolognese; M. Bonesini; W. Bonivento; P. S. L. Booth; G. Borisov; H. Borner; C. Bosio; B. Bostjancic; S. Bosworth; O. Botner; B. Bouquet; C. Bourdarios; T. J. V. Bowcock; M. Bozzo; S. Braibant; P. Branchini; K. D. Brand; R. A. Brenner; H. Briand; C. Bricman; R. C. A. Brown; N. Brummer; J.-M. Brunet; L. Bugge; T. Buran; H. Burmeister; J. A. M. A. Buytaert; M. Caccia; M. Calvi; A. J. Camacho Rozas; R. Campion; T. Camporesi; V. Canale; F. Cao; F. Carena; L. Carroll; M. V. Castillo Gimenez; A. Cattai; F. R. Cavallo; L. Cerrito; V. Chabaud; A. Chan; Ph. Charpentier; L. Chaussard; J. Chauveau; P. Checchia; G. A. Chelkov; L. Chevalier; P. Chliapnikov; V. Chorowicz; J. T. M. Chrin; M. P. Clara; P. Collins; J. L. Contreras; R. Contri; E. Cortina; G. Cosme; F. Couchot; H. B. Crawley; D. Crennell; G. Crosetti; M. Crozon; J. Cuevas Maestro; S. Czellar; E. Dahl-Jensen; B. Dalmagne; M. Dam; G. Damgaard; G. Darbo; E. Daubie; A. Daum; P. D. Dauncey; M. Davenport; P. David; J. Davies; W. Da Silva; C. Defoix; P. Delpierre; N. Demaria; A. De Angelis; H. De Boeck; W. De Boer; C. De Clercq; M. D. M. De Fez Laso; N. De Groot; C. De La Vaissiere; B. De Lotto; A. De Min; H. Dijkstra; L. Di Ciaccio; F. Djama; J. Dolbeau; M. Donszelmann; K. Doroba; M. Dracos; J. Drees; M. Dris; Y. Dufour; F. Dupont; L.-O. Eek; P. A.-M. Eerola; R. Ehret; T. Ekelof; G. Ekspong; A. Elliot Peisert; J.-P. Engel; N. Ershaidat; D. Fassouliotis; M. Feindt; A. Fenyuk; M. Fernandez Alonso; A. Ferrer; T. A. Filippas; A. Firestone; H. Foeth; E. Fokitis; F. Fontanelli; K. A. J. Forbes; J.-L. Fousset; S. Francon; B. Franek; P. Frenkiel; D. C. Fries; A. G. Frodesen; R. Fruhwirth; F. Fulda-Quenzer; K. Furnival; H. Furstenau; J. Fuster; D. Gamba; C. Garcia; J. Garcia; C. Gaspar; U. Gasparini; Ph. Gavillet; E. N. Gazis; J.-P. Gerber; P. Giacomelli; R. Gokieli; B. Golob; V. M. Golovatyuk; J. J. Gomez Y Cadenas; A. Goobar; G. Gopal; M. Gorski; V. Gracco; A. Grant; F. Grard; E. Graziani; G. Grosdidier; E. Gross; P. Grosse-Wiesmann; B. Grossetete; S. Gumenyuk; J. Guy; U. Haedinger; F. Hahn; M. Hahn; S. Haider; Z. Hajduk; A. Hakansson; A. Hallgren; K. Hamacher; G. Hamel De Monchenault; W. Hao; F. J. Harris; V. Hedberg; T. Henkes; J. J. Hernandez; P. Herquet; H. Herr; T. L. Hessing; I. Hietanen; C. O. Higgins; E. Higon; H. J. Hilke; S. D. Hodgson; T. Hofmokl; R. Holmes; S.-O. Holmgren; D. Holthuizen; P. F. Honore; J. E. Hooper; M. Houlden; J. Hrubec; K. Huet; P. O. Hulth; K. Hultqvist; P. Ioannou; P.-S. Iversen; J. N. Jackson; P. Jalocha; G. Jarlskog; P. Jarry; B. Jean-Marie; E. K. Johansson; D. Johnson; M. Jonker; L. Jonsson; P. Juillot; G. Kalkanis; G. Kalmus; F. Kapusta; M. Karlsson; E. Karvelas; S. Katsanevas; E. C. Katsoufis; R. Keranen; J. Kesteman; B. A. Khomenko; N. N. Khovanski; B. King; N. J. Kjaer; H. Klein; A. Klovning; P. Kluit; A. Koch-Mehrin; J. H. Koehne; B. Koene; P. Kokkinias; M. Koratzinos; K. Korcyl; A. V. Korytov; V. Kostioukhine; C. Kourkoumelis; O. Kouznetsov; P. H. Kramer; J. Krolikowski; I. Kronkvist; U. Kruener-Marquis; W. Kucewicz; K. Kulka; K. Kurvinen; C. Lacasta; C. Lambropoulos; J. W. Lamsa; L. Lanceri; V. Lapin; J.-P. Laugier; R. Lauhakangas; G. Leder; F. Ledroit; R. Leitner; Y. Lemoigne; J. Lemonne; G. Lenzen; V. Lepeltier; T. Lesiak; J. M. Levy; E. Lieb; D. Liko; J. Lindgren; R. Lindner; A. Lipniacka; I. Lippi; B. Loerstad; M. Lokajicek; J. G. Loken; A. Lopez-Fernandez; M. A. Lopez Aguera; M. Los; D. Loukas; J. J. Lozano; P. Lutz; L. Lyons; G. Maehlum; J. Maillard; A. Maio; A. Maltezos; F. Mandl; J. Marco; M. Margoni; J.-C. Marin; A. Markou; T. Maron; S. Marti; L. Mathis; F. Matorras; C. Matteuzzi; G. Matthiae; M. Mazzucato; M. Mc Cubbin; R. Mc Nay; R. Mc Nulty; G. Meola; C. Meroni; W. T. Meyer; M. Michelotto; I. Mikulec; L. Mirabito; W. A. Mitaroff; G. V. Mitselmakher; U. Mjoernmark; T. Moa; R. Moeller; K. Moenig; M. R. Monge; P. Morettini; H. Mueller; W. J. Murray; G. Myatt; F. L. Navarria; P. Negri; B. S. Nielsen; B. Nijjhar; V. Nikolaenko; P. E. S. Nilsen; P. Niss; V. Obraztsov; A. G. Olshevski; R. Orava; A. Ostankov; K. Osterberg; A. Ouraou; M. Paganoni; R. Pain; Th. D. Papadopoulou; L. Pape; F. Parodi; A. Passeri

    1993-01-01

    The tau lepton lifetime is measured using four different methods with the DELPHI detector. Three measurements using one prong decays are combined, accounting for correlations, resulting in tautau=298 +\\/-7 (stat.)+\\/-4 (syst.) fs while the decay length distribution of three prong decays gives pipi=298+\\/-13 (stat)+\\/-(syst.) fs. The combined result is tautau=298+\\/-7 fs. The ratio of the Fermi coupling constant from tau

  18. Search for neutral Higgs bosons decaying to tau pairs in pp collisions at ?s = 7 TeV

    E-print Network

    Alver, B.

    A search for neutral Higgs bosons decaying to tau pairs at a center-of-mass energy of 7 TeV is performed using a dataset corresponding to an integrated luminosity of 4.6 fb[superscript ?1] recorded by the CMS experiment ...

  19. Chiral sum rules and vacuum condensates from tau-lepton decay data

    E-print Network

    C. A. Dominguez; L. A. Hernandez; K. Schilcher; H. Spiesberger

    2015-02-16

    QCD finite energy sum rules, together with the latest updated ALEPH data on hadronic decays of the tau-lepton are used in order to determine the vacuum condensates of dimension $d=2$ and $d=4$. These data are also used to check the validity of the Weinberg sum rules, and to determine the chiral condensates of dimension $d=6$ and $d=8$, as well as the chiral correlator at zero momentum, proportional to the counter term of the ${\\cal{O}}(p^4)$ Lagrangian of chiral perturbation theory, $\\bar{L}_{10}$. Suitable (pinched) integration kernels are introduced in the sum rules in order to suppress potential quark-hadron duality violations. We find no compelling indications of duality violations in the kinematic region above $s \\simeq 2.2$ GeV$^2$ after using pinched integration kernels.

  20. Improved Limits on Lepton-Flavor-Violating tau Decays to lvarphi, lrho, lK*, and l Kmacr

    Microsoft Academic Search

    B. Aubert; Y. Karyotakis; J. P. Lees; V. Poireau; E. Prencipe; X. Prudent; V. Tisserand; J. Garra Tico; E. Grauges; M. Martinelli; A. Palano; M. Pappagallo; G. Eigen; B. Stugu; L. Sun; M. Battaglia; D. N. Brown; L. T. Kerth; Yu. G. Kolomensky; G. Lynch; I. L. Osipenkov; K. Tackmann; T. Tanabe; C. M. Hawkes; N. Soni; A. T. Watson; H. Koch; T. Schroeder; D. J. Asgeirsson; B. G. Fulsom; C. Hearty; T. S. Mattison; J. A. McKenna; M. Barrett; A. Khan; A. Randle-Conde; V. E. Blinov; A. D. Bukin; A. R. Buzykaev; V. P. Druzhinin; V. B. Golubev; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; K. Yu. Todyshev; M. Bondioli; S. Curry; I. Eschrich; D. Kirkby; A. J. Lankford; P. Lund; M. Mandelkern; E. C. Martin; D. P. Stoker; S. Abachi; C. Buchanan; H. Atmacan; J. W. Gary; F. Liu; O. Long; G. M. Vitug; Z. Yasin; L. Zhang; V. Sharma; C. Campagnari; T. M. Hong; D. Kovalskyi; M. A. Mazur; J. D. Richman; T. W. Beck; A. M. Eisner; C. A. Heusch; J. Kroseberg; W. S. Lockman; A. J. Martinez; T. Schalk; B. A. Schumm; A. Seiden; L. O. Winstrom; C. H. Cheng; D. A. Doll; B. Echenard; F. Fang; D. G. Hitlin; I. Narsky; T. Piatenko; F. C. Porter; R. Andreassen; G. Mancinelli; B. T. Meadows; K. Mishra; M. D. Sokoloff; P. C. Bloom; W. T. Ford; A. Gaz; J. F. Hirschauer; M. Nagel; U. Nauenberg; J. G. Smith; S. R. Wagner; R. Ayad; A. Soffer; W. H. Toki; R. J. Wilson; E. Feltresi; A. Hauke; H. Jasper; T. M. Karbach; J. Merkel; A. Petzold; B. Spaan; K. Wacker; M. J. Kobel; R. Nogowski; K. R. Schubert; R. Schwierz; A. Volk; D. Bernard; G. R. Bonneaud; E. Latour; M. Verderi; P. J. Clark; S. Playfer; J. E. Watson; M. Andreotti; D. Bettoni; C. Bozzi; R. Calabrese; A. Cecchi; G. Cibinetto; E. Fioravanti; P. Franchini; E. Luppi; M. Munerato; M. Negrini; A. Petrella; L. Piemontese; V. Santoro; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; G. Finocchiaro; S. Pacetti; P. Patteri; I. M. Peruzzi; M. Piccolo; M. Rama; A. Zallo; R. Contri; E. Guido; M. Lo Vetere; M. R. Monge; S. Passaggio; C. Patrignani; E. Robutti; S. Tosi; K. S. Chaisanguanthum; M. Morii; A. Adametz; J. Marks; S. Schenk; U. Uwer; F. U. Bernlochner; V. Klose; H. M. Lacker; D. J. Bard; P. D. Dauncey; M. Tibbetts; P. K. Behera; M. J. Charles; U. Mallik; J. Cochran; H. B. Crawley; L. Dong; V. Eyges; W. T. Meyer; S. Prell; E. I. Rosenberg; A. E. Rubin; Y. Y. Gao; A. V. Gritsan; Z. J. Guo; N. Arnaud; J. Béquilleux; A. D'Orazio; M. Davier; D. Derkach; J. Firmino da Costa; G. Grosdidier; F. Le Diberder; V. Lepeltier; A. M. Lutz; B. Malaescu; S. Pruvot; P. Roudeau; M. H. Schune; J. Serrano; V. Sordini; A. Stocchi; G. Wormser; D. J. Lange; D. M. Wright; I. Bingham; J. P. Burke; C. A. Chavez; J. R. Fry; E. Gabathuler; R. Gamet; D. E. Hutchcroft; D. J. Payne; C. Touramanis; A. J. Bevan; C. K. Clarke; F. di Lodovico; R. Sacco; M. Sigamani; G. Cowan; S. Paramesvaran; A. C. Wren; C. L. Davis; A. G. Denig; M. Fritsch; W. Gradl; A. Hafner; K. E. Alwyn; D. Bailey; R. J. Barlow; G. Jackson; G. D. Lafferty; T. J. West; J. I. Yi; J. Anderson; C. Chen; A. Jawahery; D. A. Roberts; G. Simi; J. M. Tuggle; C. Dallapiccola; E. Salvati; S. Saremi; R. Cowan; D. Dujmic; P. H. Fisher; S. W. Henderson; G. Sciolla; M. Spitznagel; R. K. Yamamoto; M. Zhao; P. M. Patel; S. H. Robertson; M. Schram; A. Lazzaro; V. Lombardo; F. Palombo; S. Stracka; J. M. Bauer; L. Cremaldi; R. Godang; R. Kroeger; D. J. Summers; H. W. Zhao; M. Simard; P. Taras; H. Nicholson; G. de Nardo; L. Lista; D. Monorchio; G. Onorato; C. Sciacca; G. Raven; H. L. Snoek; C. P. Jessop; K. J. Knoepfel; J. M. Losecco; W. F. Wang; L. A. Corwin; K. Honscheid; H. Kagan; R. Kass; J. P. Morris; A. M. Rahimi; J. J. Regensburger; S. J. Sekula; Q. K. Wong; N. L. Blount; J. Brau; R. Frey; O. Igonkina; J. A. Kolb; M. Lu; R. Rahmat; N. B. Sinev; D. Strom; J. Strube; E. Torrence; G. Castelli; N. Gagliardi; M. Margoni; M. Morandin; M. Posocco; M. Rotondo; F. Simonetto; R. Stroili; C. Voci; P. Del Amo Sanchez; E. Ben-Haim; H. Briand; J. Chauveau; O. Hamon; Ph. Leruste; G. Marchiori; J. Ocariz; A. Perez; J. Prendki; S. Sitt; L. Gladney; M. Biasini; E. Manoni; C. Angelini; G. Batignani; S. Bettarini; G. Calderini; M. Carpinelli; A. Cervelli; F. Forti; M. A. Giorgi; A. Lusiani; M. Morganti; N. Neri; E. Paoloni; G. Rizzo; J. J. Walsh; D. Lopes Pegna; C. Lu; J. Olsen; A. J. S. Smith; A. V. Telnov; F. Anulli; E. Baracchini; G. Cavoto; R. Faccini; F. Ferrarotto; F. Ferroni; M. Gaspero; P. D. Jackson; L. Li Gioi; M. A. Mazzoni; S. Morganti; G. Piredda; F. Renga; C. Voena; M. Ebert; T. Hartmann; H. Schröder; R. Waldi; T. Adye; B. Franek; E. O. Olaiya; F. F. Wilson; S. Emery; L. Esteve; G. Hamel de Monchenault; W. Kozanecki; G. Vasseur; Ch. Yèche; M. Zito; M. T. Allen; D. Aston; R. Bartoldus; J. F. Benitez; R. Cenci; J. P. Coleman; M. R. Convery; J. C. Dingfelder; J. Dorfan; G. P. Dubois-Felsmann; W. Dunwoodie

    2009-01-01

    We search for the neutrinoless, lepton-flavor-violating tau decays tau--->l-V0, where l is an electron or muon and V0 is a vector meson reconstructed as varphi-->K+K-, rho-->pi+pi-, K*-->K+pi-, Kmacr *-->K-pi+. The analysis has been performed using 451fb-1 of data collected at an e+e- center-of-mass energy near 10.58 GeV with the BABAR detector at the PEP-II storage rings. The number of events

  1. Can we see tau-Flavour Violation at the LHC?

    SciTech Connect

    Carquin, E. [Departamento de Fisica y Centro de Estudios Subatomicos, Universidad Tecnica Federico Santa Maria, Casilla 110-V, Valparaiso (Chile); Gomez, M. E.; Rodriguez-Quintero, J. [Department of Applied Physics, University of Huelva, 21071 Huelva (Spain)

    2010-02-10

    We study the conditions required for chi{sub 2}->chi+tau{sup +}-mu{sup +}- decays to yield observable tau flavour violation at the LHC, for cosmologically interesting values of the neutralino relic density.

  2. Search for the Higgs Boson Decaying to Two Tau Leptons in Proton-Antiproton Collisions at a Center of Mass Energy of 1.96 TeV

    E-print Network

    Elagin, Andrey

    2012-02-14

    A search for the Higgs boson decaying to tau tau using 7.8 fb^-1 of pp collisions at 1.96 TeV collected with CDF II detector is presented. The search is sensitive to four production mechanisms of the Higgs boson: ggH, WH, ZH and VBF. Modes where one...

  3. Measurement of the branching ratio for the process b-->tau-nu¯tauX

    Microsoft Academic Search

    G. Abbiendi; C. Ainsley; P. F. Åkesson; G. Alexander; J. Allison; G. Anagnostou; K. J. Anderson; S. Arcelli; S. Asai; D. Axen; G. Azuelos; I. Bailey; E. Barberio; R. J. Barlow; R. J. Batley; T. Behnke; K. W. Bell; P. J. Bell; G. Bella; A. Bellerive; S. Bethke; O. Biebel; I. J. Bloodworth; O. Boeriu; P. Bock; J. Böhme; D. Bonacorsi; M. Boutemeur; S. Braibant; L. Brigliadori; R. M. Brown; H. J. Burckhart; J. Cammin; R. K. Carnegie; B. Caron; A. A. Carter; J. R. Carter; C. Y. Chang; D. G. Charlton; P. E. L. Clarke; E. Clay; I. Cohen; J. Couchman; A. Csilling; M. Cuffiani; S. Dado; G. M. Dallavalle; S. Dallison; A. De Roeck; E. A. De Wolf; P. Dervan; K. Desch; B. Dienes; M. S. Dixit; M. Donkers; J. Dubbert; E. Duchovni; G. Duckeck; I. P. Duerdoth; E. Etzion; F. Fabbri; L. Feld; P. Ferrari; F. Fiedler; I. Fleck; M. Ford; A. Frey; A. Fürtjes; D. I. Futyan; P. Gagnon; J. W. Gary; G. Gaycken; C. Geich-Gimbel; G. Giacomelli; P. Giacomelli; D. Glenzinski; J. Goldberg; K. Graham; E. Gross; J. Grunhaus; M. Gruwé; P. O. Günther; A. Gupta; C. Hajdu; M. Hamann; G. G. Hanson; K. Harder; A. Harel; M. Harin-Dirac; M. Hauschild; J. Hauschildt; C. M. Hawkes; R. Hawkings; R. J. Hemingway; C. Hensel; G. Herten; R. D. Heuer; J. C. Hill; K. Hoffman; R. J. Homer; D. Horváth; K. R. Hossain; R. Howard; P. Hüntemeyer; P. Igo-Kemenes; K. Ishii; A. Jawahery; H. Jeremie; C. R. Jones; P. Jovanovic; T. R. Junk; N. Kanaya; J. Kanzaki; G. Karapetian; D. Karlen; V. Kartvelishvili; K. Kawagoe; T. Kawamoto; R. K. Keeler; R. G. Kellogg; B. W. Kennedy; D. H. Kim; K. Klein; A. Klier; S. Kluth; T. Kobayashi; M. Kobel; T. P. Kokott; S. Komamiya; R. V. Kowalewski; T. Krämer; T. Kress; P. Krieger; J. von Krogh; D. Krop; T. Kuhl; M. Kupper; P. Kyberd; G. D. Lafferty; H. Landsman; D. Lanske; I. Lawson; J. G. Layter; A. Leins; D. Lellouch; J. Letts; L. Levinson; J. Lillich; C. Littlewood; S. L. Lloyd; F. K. Loebinger; G. D. Long; M. J. Losty; J. Lu; J. Ludwig; A. Macchiolo; A. Macpherson; W. Mader; S. Marcellini; T. E. Marchant; A. J. Martin; J. P. Martin; G. Martinez; G. Masetti; T. Mashimo; P. Mättig; W. J. McDonald; J. McKenna; T. J. McMahon; R. A. McPherson; F. Meijers; P. Mendez-Lorenzo; W. Menges; F. S. Merritt; H. Mes; A. Michelini; S. Mihara; G. Mikenberg; D. J. Miller; S. Moed; W. Mohr; T. Mori; A. Mutter; K. Nagai; I. Nakamura; H. A. Neal; R. Nisius; S. W. O'Neale; A. Oh; A. Okpara; M. J. Oreglia; S. Orito; C. Pahl; G. Pásztor; J. R. Pater; G. N. Patrick; J. E. Pilcher; J. Pinfold; D. E. Plane; B. Poli; J. Polok; O. Pooth; A. Quadt; K. Rabbertz; C. Rembser; P. Renkel; H. Rick; N. Rodning; J. M. Roney; S. Rosati; K. Roscoe; Y. Rozen; K. Runge; D. R. Rust; K. Sachs; T. Saeki; O. Sahr; E. K. G. Sarkisyan; C. Sbarra; A. D. Schaile; O. Schaile; P. Scharff-Hansen; C. Schmitt; M. Schröder; M. Schumacher; C. Schwick; W. G. Scott; R. Seuster; T. G. Shears; B. C. Shen; C. H. Shepherd-Themistocleous; P. Sherwood; A. Skuja; A. M. Smith; G. A. Snow; R. Sobie; S. Söldner-Rembold; S. Spagnolo; F. Spano; M. Sproston; A. Stahl; K. Stephens; D. Strom; R. Ströhmer; L. Stumpf; B. Surrow; S. Tarem; M. Tasevsky; R. J. Taylor; R. Teuscher; J. Thomas; M. A. Thomson; E. Torrence; D. Toya; T. Trefzger; A. Tricoli; I. Trigger; Z. Trócsányi; E. Tsur; M. F. Turner-Watson; I. Ueda; B. Ujvári; B. Vachon; C. F. Vollmer; P. Vannerem; M. Verzocchi; H. Voss; J. Vossebeld; D. Waller; C. P. Ward; D. R. Ward; P. M. Watkins; A. T. Watson; N. K. Watson; P. S. Wells; T. Wengler; N. Wermes; D. Wetterling; G. W. Wilson; J. A. Wilson; T. R. Wyatt; S. Yamashita; V. Zacek; D. Zer-Zion

    2001-01-01

    The inclusive branching ratio for the process b-->tau-nu¯tauX has been measured using hadronic Z decays collected by the OPAL experiment at LEP in the years 1992-2000. The result is: BR(b-->tau-nu¯tauX)=(2.78+\\/-0.18+\\/- 0.51)%. This measurement is consistent with the Standard Model expectation and puts a constraint of tanbeta\\/MH+\\/-<0.53 GeV-1 at the \\/95% confidence level on Type II Two Higgs Doublet Models.

  4. VLHC Predictions for H to tau tau in Weak Boson Fusion

    Microsoft Academic Search

    T. Plehn; S. Su; D. Zeppenfeld

    2001-01-01

    Higgs production in weak boson fusion with subsequent decay H to tau tau to e mu p_T_miss provides a means to measure Higgs Yukawa couplings and Higgs interactions to weak bosons. The potential precision of cross section measurements at a VLHC is investigated.

  5. VLHC Predictions for H to tau tau in Weak Boson Fusion

    E-print Network

    T. Plehn; S. Su; D. Zeppenfeld

    2001-10-28

    Higgs production in weak boson fusion with subsequent decay H to tau tau to e mu p_T_miss provides a means to measure Higgs Yukawa couplings and Higgs interactions to weak bosons. The potential precision of cross section measurements at a VLHC is investigated.

  6. Upper limit on the tau-neutrino mass

    SciTech Connect

    Abachi, S.; Akerlof, C.; Baringer, P.; Beltrami, I.; Blockus, D.; Bonvicini, G.; Brabson, B.; Bylsma, B.G.; Chapman, J.; Cork, B.

    1986-03-10

    A sample of tau-lepton decays to 5..pi../sup + -/..nu../sub tau/ and 5..pi../sup + -/..pi../sup 0/..nu../sub tau/, observed in the high-resolution spectrometer at the SLAC e/sup +/e/sup -/ storage ring PEP, have been used to place an upper limit on the mass of the tau neutrino of 84 MeV/c/sup 2/ at the 95% confidence level.

  7. Search for Lepton Flavor Violating Decays tau±-->l±pi0, l±eta, l±eta'

    Microsoft Academic Search

    B. Aubert; M. Bona; D. Boutigny; F. Couderc; Y. Karyotakis; J. P. Lees; V. Poireau; V. Tisserand; A. Zghiche; E. Grauges; A. Palano; J. C. Chen; N. D. Qi; G. Rong; P. Wang; Y. S. Zhu; G. Eigen; I. Ofte; B. Stugu; G. S. Abrams; M. Battaglia; D. N. Brown; J. Button-Shafer; R. N. Cahn; E. Charles; M. S. Gill; Y. Groysman; R. G. Jacobsen; J. A. Kadyk; L. T. Kerth; Yu. G. Kolomensky; G. Kukartsev; D. Lopes Pegna; G. Lynch; L. M. Mir; T. J. Orimoto; M. Pripstein; N. A. Roe; M. T. Ronan; W. A. Wenzel; P. Del Amo Sanchez; M. Barrett; K. E. Ford; T. J. Harrison; A. J. Hart; C. M. Hawkes; A. T. Watson; T. Held; H. Koch; B. Lewandowski; M. Pelizaeus; K. Peters; T. Schroeder; M. Steinke; J. T. Boyd; J. P. Burke; W. N. Cottingham; D. Walker; D. J. Asgeirsson; T. Cuhadar-Donszelmann; B. G. Fulsom; C. Hearty; N. S. Knecht; T. S. Mattison; J. A. McKenna; A. Khan; P. Kyberd; M. Saleem; D. J. Sherwood; L. Teodorescu; V. E. Blinov; A. D. Bukin; V. P. Druzhinin; V. B. Golubev; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; K. Yu. Todyshev; D. S. Best; M. Bondioli; M. Bruinsma; M. Chao; S. Curry; I. Eschrich; D. Kirkby; A. J. Lankford; P. Lund; M. Mandelkern; W. Roethel; D. P. Stoker; S. Abachi; C. Buchanan; S. D. Foulkes; J. W. Gary; O. Long; B. C. Shen; K. Wang; L. Zhang; H. K. Hadavand; E. J. Hill; H. P. Paar; S. Rahatlou; V. Sharma; J. W. Berryhill; C. Campagnari; A. Cunha; B. Dahmes; T. M. Hong; D. Kovalskyi; J. D. Richman; T. W. Beck; A. M. Eisner; C. J. Flacco; C. A. Heusch; J. Kroseberg; W. S. Lockman; G. Nesom; T. Schalk; B. A. Schumm; A. Seiden; P. Spradlin; D. C. Williams; M. G. Wilson; J. Albert; E. Chen; C. H. Cheng; A. Dvoretskii; F. Fang; D. G. Hitlin; I. Narsky; T. Piatenko; F. C. Porter; G. Mancinelli; B. T. Meadows; K. Mishra; M. D. Sokoloff; F. Blanc; P. C. Bloom; S. Chen; W. T. Ford; J. F. Hirschauer; A. Kreisel; M. Nagel; U. Nauenberg; A. Olivas; W. O. Ruddick; J. G. Smith; K. A. Ulmer; S. R. Wagner; J. Zhang; A. Chen; E. A. Eckhart; A. Soffer; W. H. Toki; R. J. Wilson; F. Winklmeier; Q. Zeng; D. D. Altenburg; E. Feltresi; A. Hauke; H. Jasper; J. Merkel; A. Petzold; B. Spaan; T. Brandt; V. Klose; H. M. Lacker; W. F. Mader; R. Nogowski; J. Schubert; K. R. Schubert; R. Schwierz; J. E. Sundermann; A. Volk; D. Bernard; G. R. Bonneaud; E. Latour; Ch. Thiebaux; M. Verderi; P. J. Clark; W. Gradl; F. Muheim; S. Playfer; A. I. Robertson; Y. Xie; M. Andreotti; D. Bettoni; C. Bozzi; R. Calabrese; G. Cibinetto; E. Luppi; M. Negrini; A. Petrella; L. Piemontese; E. Prencipe; F. Anulli; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; G. Finocchiaro; S. Pacetti; P. Patteri; I. M. Peruzzi; M. Piccolo; M. Rama; A. Zallo; A. Buzzo; R. Contri; M. Lo Vetere; M. M. Macri; M. R. Monge; S. Passaggio; C. Patrignani; E. Robutti; A. Santroni; S. Tosi; G. Brandenburg; K. S. Chaisanguanthum; C. L. Lee; M. Morii; J. Wu; R. S. Dubitzky; J. Marks; S. Schenk; U. Uwer; D. J. Bard; W. Bhimji; D. A. Bowerman; P. D. Dauncey; U. Egede; R. L. Flack; J. A. Nash; M. B. Nikolich; W. Panduro Vazquez; P. K. Behera; X. Chai; M. J. Charles; U. Mallik; N. T. Meyer; V. Ziegler; J. Cochran; H. B. Crawley; L. Dong; V. Eyges; W. T. Meyer; S. Prell; E. I. Rosenberg; A. E. Rubin; A. V. Gritsan; A. G. Denig; M. Fritsch; G. Schott; N. Arnaud; M. Davier; G. Grosdidier; A. Höcker; V. Lepeltier; F. Le Diberder; A. M. Lutz; A. Oyanguren; S. Pruvot; S. Rodier; P. Roudeau; M. H. Schune; J. Serrano; A. Stocchi; W. F. Wang; G. Wormser; D. J. Lange; D. M. Wright; C. A. Chavez; I. J. Forster; J. R. Fry; E. Gabathuler; R. Gamet; K. A. George; D. E. Hutchcroft; D. J. Payne; K. C. Schofield; C. Touramanis; A. J. Bevan; C. K. Clarke; F. Di Lodovico; W. Menges; R. Sacco; G. Cowan; H. U. Flaecher; D. A. Hopkins; P. D. Jackson; T. R. McMahon; F. Salvatore; A. C. Wren; C. L. Davis; J. Allison; N. R. Barlow; R. J. Barlow; Y. M. Chia; C. L. Edgar; G. D. Lafferty; M. T. Naisbit; J. C. Williams; J. I. Yi; C. Chen; W. D. Hulsbergen; A. Jawahery; C. K. Lae; D. A. Roberts; G. Simi; G. Blaylock; C. Dallapiccola; S. S. Hertzbach; X. Li; T. B. Moore; S. Saremi; H. Staengle; R. Cowan; G. Sciolla; S. J. Sekula; M. Spitznagel; F. Taylor; R. K. Yamamoto; H. Kim; S. E. McLachlin; P. M. Patel; S. H. Robertson; A. Lazzaro; V. Lombardo; F. Palombo; J. M. Bauer; L. Cremaldi; V. Eschenburg; R. Godang; R. Kroeger; D. A. Sanders; D. J. Summers; H. W. Zhao; S. Brunet; D. Côté; M. Simard; P. Taras; F. B. Viaud; H. Nicholson; N. Cavallo; G. De Nardo; F. Fabozzi; C. Gatto; L. Lista; D. Monorchio; P. Paolucci; D. Piccolo; C. Sciacca; M. A. Baak; G. Raven; H. L. Snoek; C. P. Jessop; J. M. Losecco; G. Benelli; L. A. Corwin; K. K. Gan; K. Honscheid; D. Hufnagel; H. Kagan; R. Kass; A. M. Rahimi; J. J. Regensburger; R. Ter-Antonyan; Q. K. Wong; N. L. Blount; J. Brau; R. Frey; O. Igonkina; J. A. Kolb; M. Lu; C. T. Potter; R. Rahmat

    2007-01-01

    A search for lepton flavor violating decays of the tau lepton to a lighter mass lepton and a pseudoscalar meson has been performed using 339fb-1 of e+e- annihilation data collected at a center-of-mass energy near 10.58 GeV by the BABAR detector at the SLAC PEP-II storage ring. No evidence of a signal has been found, and upper limits on the

  8. Bilocal expansion of the Borel amplitude and the hadronic tau decay width

    SciTech Connect

    Cvetic, Gorazd; Lee, Taekoon

    2001-07-01

    The singular part of the Borel transform of a QCD amplitude near the infrared renormalon can be expanded in terms of higher order Wilson coefficients of the operators associated with the renormalon. In this paper we observe that this expansion gives nontrivial constraints on the Borel amplitude that can be used to improve the accuracy of the ordinary perturbative expansion of the Borel amplitude. In particular, we consider the Borel transform of the Adler function and its expansion around the first infrared renormalon due to the gluon condensate. Using the next-to-leading order (NLO) Wilson coefficient of the gluon condensate operator, we obtain an exact constraint on the Borel amplitude at the first IR renormalon. We then extrapolate, using judiciously chosen conformal transformations and Pade{prime} approximants, the ordinary perturbative expansion of the Borel amplitude in such a way that this constraint is satisfied. This procedure allows us to predict the O({alpha}{sub s}{sup 4}) coefficient of the Adler function, which gives a result consistent with the estimate by Kataev and Starshenko using a completely different method. We then apply this improved Borel amplitude to the tau decay width and obtain the strong coupling constant {alpha}{sub s}(M{sub z}{sup 2})=0.1193{+-}0.0007{sub exp.}{+-}0.0010{sub EW+CKM}{+-}0.0009{sub meth.}{+-}0.0003{sub evol.}. We then compare this result with those of other resummation methods.

  9. Search for lepton flavor violating decay $\\tau^- \\to \\ell^- \\ell^ \\ell^-$ at BaBar

    SciTech Connect

    Cervelli, Alberto; /Pisa U.

    2010-05-26

    The Standard Model (SM) is one of the most tested and verified physical theories of all time, present experimental observations are consistent with SM expectations. On the other hand SM can not explain many physical observations: the cosmological observations possibly infer the presence of dark matter which is clearly beyond the SM expectations; the SM Higgs model, while explaining the generation of fermion masses, can not explain the hierarchy problem and a non natural fine tuning of SM is needed to cancel out quadratic divergences in the Higgs boson mass. New physics (NP) beyond SM should hence be investigated: rising the energy above NP processes thresholds, and detecting new particles or new effects not predicted by the standard model directly, is one of the possible approaches; another approach is to make precision measurements of well known processes or looking for rare processes which involve higher order contribution from NP processes, this approach need higher luminosities with respect to the previous approach but lower beam energies. Search for Lepton Flavor Violation (LFV) in charged lepton decays is promising: neutrino physics provides indeed a clear and unambiguous evidence of LFV in the neutral lepton sector via mixing processes, which have been observed for the first time by the Homestake collaboration. We expect LFV in the charged sector as well, both in {mu} and {tau} sector, but current experimental searches for LFV processes did not find any evidence for those processes, and more results are expected to come from new experiments in the coming years.

  10. Vector Boson Fusion Higgs to Tau Tau Searches at the ATLAS Experiment

    E-print Network

    K. J. C. Leney; for the ATLAS Collaboration

    2008-10-17

    The search for a Higgs boson produced via Vector Boson Fusion and subsequently decaying to two tau leptons is discussed. Significances for the di-lepton and lepton-hadron decay channels are presented, and the fully hadronic decay channel is shown to be feasible in terms of trigger, mass reconstruction and signal efficiency. We consider performance issues for tau ID, missing transverse energy, forward jet identification, and central jet and b-jet vetoes, and outline several methods to estimate background contributions.

  11. Search for MSSM Higgs decaying to tau pairs in ppbar collision at s**(1/2) = 1.96 TeV at CDF

    SciTech Connect

    Jang, Dongwook

    2006-05-01

    This thesis presents the search for neutral Minimal Supersymmetric extension of Standard Model (MSSM) Higgs bosons decaying to tau pairs where one of the taus decays leptonically, and the other one hadronically. CDF Run II data with L{sub int} = 310 pb{sup -1} are used. There is no evidence of MSSM Higgs existence, which results in the upper limits on {sigma}(p{bar p} {yields} {phi}) x BR({phi} {yields} {tau}{tau}) in m{sub A} range between 115 and 250 GeV. These limits exclude some area in tan {beta} vs m{sub A} parameter space.

  12. Electronic branching ratio of the tau lepton

    Microsoft Academic Search

    R. Ammar; P. Baringer; D. Coppage; R. Davis; M. Kelly; N. Kwak; H. Lam; S. Ro; Y. Kubota; M. Lattery; J. K. Nelson; D. Perticone; R. Poling; S. Schrenk; R. Wang; M. S. Alam; I. J. Kim; B. Nemati; V. Romero; C. R. Sun; P.-N. Wang; M. M. Zoeller; G. Crawford; R. Fulton; K. K. Gan; H. Kagan; R. Kass; J. Lee; R. Malchow; F. Morrow; M. K. Sung; J. Whitmore; P. Wilson; F. Butler; X. Fu; G. Kalbfleisch; M. Lambrecht; P. Skubic; J. Snow; P.-L. Wang; D. Bortoletto; D. N. Brown; J. Dominick; R. L. McIlwain; D. H. Miller; M. Modesitt; E. I. Shibata; S. F. Schaffner; I. P. J. Shipsey; M. Battle; J. Ernst; H. Kroha; S. Roberts; K. Sparks; E. H. Thorndike; C.-H. Wang; R. Stroynowski; M. Artuso; M. Goldberg; T. Haupt; N. Horwitz; R. Kennett; G. C. Moneti; S. Playfer; Y. Rozen; P. Rubin; T. Skwarnicki; S. Stone; M. Thulasidas; W.-M. Yao; G. Zhu; A. V. Barnes; J. Bartelt; S. E. Csorna; V. Jain; T. Letson; M. D. Mestayer; D. S. Akerib; B. Barish; M. Chadha; D. F. Cowen; G. Eigen; J. S. Miller; J. Urheim; A. J. Weinstein; R. J. Morrison; H. Tajima; D. Schmidt; D. Sperka; M. Procario; M. Daoudi; W. T. Ford; D. R. Johnson; K. Lingel; M. Lohner; P. Rankin; J. G. Smith; J. Alexander; C. Bebek; K. Berkelman; D. Besson; T. E. Browder; D. G. Cassel; E. Cheu; D. M. Coffman; P. S. Drell; R. Ehrlich; R. S. Galik; M. Garcia-Sciveres; B. Geiser; B. Gittelman; S. W. Gray; D. L. Hartill; B. K. Heltsley; K. Honscheid; C. Jones; J. Kandaswamy; N. Katayama; P. C. Kim; D. L. Kreinick; G. S. Ludwig; J. Masui; J. Mevissen; N. B. Mistry; S. Nandi; C. R. Ng; E. Nordberg; C. O'grady; J. R. Patterson; D. Peterson; D. Riley; M. Sapper; M. Selen; H. Worden; M. Worris; F. Würthwein; P. Avery; A. Freyberger; J. Rodriguez; J. Yelton; S. Henderson; K. Kinoshita; F. Pipkin; M. Saulnier; R. Wilson; J. Wolinski; D. Xiao; H. Yamamoto; A. J. Sadoff

    1992-01-01

    Using data accumulated by the CLEO I detector operating at the Cornell Electron Storage Ring, we have measured the ratio R=Gamma(tau-->enu¯enutau)\\/Gamma1, where Gamma1 is the tau decay rate to final states with one charged particle. We find R=0.2231+\\/-0.0044+\\/-0.0073 where the first error is statistical and the second is systematic. Together with the measured topological one-charged-particle branching fraction, this yields the

  13. A Search for Supersymmetric Higgs Bosons in the Di-tau Decay Mode in Proton - Anti-proton Collisions at 1.8 TeV

    SciTech Connect

    Connolly, Amy Lynn

    2003-09-01

    A search for directly produced Supersymmetric Higgs Bosons has been performed in the di-tau decay channel in 86.3 {+-} 3.5 pb{sup -1} of data collected by CDF during Run1b at the Tevatron. They search for events where one tau decays to an electron and the other tau decays hadronically. They perform a counting experiment and set limits on the cross section for Higgs production in the high tan {beta} region of the m{sub A}-tan {beta} plane. For a benchmark parameter space point where m{sub A} = 100 and tan {beta} = 50, they set a 95% confidence level upper limit at 891 pb compared to the theoretically predicted cross section of 122 pb. For events where the tau candidates are not back-to-back, they utilize a di-tau mass reconstruction technique for the first time on hadron collider data. Limits based on a likelihood binned in di-tau mass from non-back-to-back events alone are weaker than the limits obtained from the counting experiment using the full di-tau sample.

  14. Effects of tau domain-specific antibodies and intravenous immunoglobulin on tau aggregation and aggregate degradation.

    PubMed

    Esteves-Villanueva, Jose O; Trzeciakiewicz, Hanna; Loeffler, David A; Marti?, Sanela

    2015-01-20

    Tau pathology, including neurofibrillary tangles, develops in Alzheimer's disease (AD). The aggregation and hyperphosphorylation of tau are potential therapeutic targets for AD. Administration of anti-tau antibodies reduces tau pathology in transgenic "tauopathy" mice; however, the optimal tau epitopes and conformations to target are unclear. Also unknown is whether intravenous immunoglobulin (IVIG) products, currently being evaluated in AD trials, exert effects on pathological tau. This study examined the effects of anti-tau antibodies targeting different tau epitopes and the IVIG Gammagard on tau aggregation and preformed tau aggregates. Tau aggregation was assessed by transmission electron microscopy and fluorescence spectroscopy, and the binding affinity of the anti-tau antibodies for tau was evaluated by enzyme-linked immunosorbent assays. Antibodies used were anti-tau 1-150 ("D-8"), anti-tau 259-266 ("Paired-262"), anti-tau 341-360 ("A-10"), and anti-tau 404-441 ("Tau-46"), which bind to tau's N-terminus, microtubule binding domain (MBD) repeat sequences R1 and R4, and the C-terminus, respectively. The antibodies Paired-262 and A-10, but not D-8 and Tau-46, reduced tau fibrillization and degraded preformed tau aggregates, whereas the IVIG reduced tau aggregation but did not alter preformed aggregates. The binding affinities of the antibodies for the epitope for which they were specific did not appear to be related to their effects on tau aggregation. These results confirm that antibody binding to tau's MBD repeat sequences may inhibit tau aggregation and indicate that such antibodies may also degrade preformed tau aggregates. In the presence of anti-tau antibodies, the resulting tau morphologies were antigen-dependent. The results also suggested the possibility of different pathways regulating antibody-mediated inhibition of tau aggregation and antibody-mediated degradation of preformed tau aggregates. PMID:25545358

  15. Modulation of Tau Dysfunction In Vitro

    E-print Network

    Voss, Kellen

    2011-05-31

    on tau to prevent its dysfunction. This dissertation explores how phosphorylation with GSK-3?, the major kinase believed to be involved in tau hyperphosphorylation, and interactions with Hsp70, affect tau dysfunction (polymerization) and function...

  16. A measurement of the $\\\\tau^{-} \\\\to e^{-} \\\\overline{\\\

    Microsoft Academic Search

    G Abbiendi; K Ackerstaff; Gideon Alexander; J Allison; N Altekamp; K J Anderson; S Anderson; S Arcelli; S Asai; S F Ashby; D A Axen; Georges Azuelos; A H Ball; E Barberio; R J Barlow; R Bartoldus; J Richard Batley; S Baumann; J Bechtluft; T Behnke; K W Bell; G Bella; A Bellerive; Stanislaus Cornelius Maria Bentvelsen; Siegfried Bethke; S Betts; O Biebel; A Biguzzi; S D Bird; Volker Blobel; Ian J Bloodworth; P Bock; J Böhme; D Bonacorsi; M Boutemeur; S Braibant; P G Bright-Thomas; L Brigliadori; R M Brown; Helfried J Burckhart; P Capiluppi; R K Carnegie; A A Carter; J R Carter; C Y Chang; D G Charlton; D Chrisman; C Ciocca; P E L Clarke; E Clay; I Cohen; J E Conboy; O C Cooke; C Couyoumtzelis; R L Coxe; M Cuffiani; S Dado; G M Dallavalle; R Davis; S De Jong; A de Roeck; P J Dervan; Klaus Desch; B Dienes; M S Dixit; J Dubbert; E Duchovni; G Duckeck; I P Duerdoth; D Eatough; P G Estabrooks; E Etzion; Franco Luigi Fabbri; M Fanti; A A Faust; F Fiedler; M Fierro; I Fleck; R Folman; A Fürtjes; D I Futyan; P Gagnon; J W Gary; J Gascon; S M Gascon-Shotkin; G Gaycken; C Geich-Gimbel; G Giacomelli; P Giacomelli; V Gibson; W R Gibson; D M Gingrich; D A Glenzinski; J Goldberg; W Gorn; C Grandi; K Graham; E Gross; Jacob Grunhaus; M Gruwé; G G Hanson; M Hansroul; M Hapke; K Harder; A Harel; C K Hargrove; C Hartmann; M Hauschild; C M Hawkes; R Hawkings; Richard J Hemingway; M Herndon; G Herten; R D Heuer; M D Hildreth; J C Hill; P R Hobson; M Hoch; Andreas Höcker; K Hoffman; R James Homer; A K Honma; D Horváth; K R Hossain; R Howard; P Hüntemeyer; P Igo-Kemenes; D C Imrie; K Ishii; F R Jacob; A Jawahery; H Jeremie; Martin Paul Jimack; C R Jones; P Jovanovic; T R Junk; D A Karlen; V G Kartvelishvili; K Kawagoe; T Kawamoto; P I Kayal; Richard K Keeler; R G Kellogg; B W Kennedy; D H Kim; A Klier; S Kluth; T Kobayashi; M Kobel; D S Koetke; T P Kokott; M Kolrep; S Komamiya; R V Kowalewski; T Kress; P Krieger; J Von Krogh; T Kühl; P Kyberd; G D Lafferty; Hagar Yaël Landsman; D Lanske; J Lauber; S R Lautenschlager; I Lawson; J G Layter; D Lazic; A M Lee; Daniel Lellouch; J Letts; L Levinson; R Liebisch; B List; C Littlewood; A W Lloyd; S L Lloyd; F K Loebinger; G D Long; Michael J Losty; J Ludwig; D Liu; A Macchiolo; A L MacPherson; W F Mader; M Mannelli; S Marcellini; C Markopoulos; A J Martin; J P Martin; G Martínez; T Mashimo; P Mättig; W J McDonald; J A McKenna; E A McKigney; T J McMahon; R A McPherson; F Meijers; S Menke; F S Merritt; H Mes; J Meyer; Aldo Michelini; S Mihara; G Mikenberg; D J Miller; R Mir; W Mohr; A Montanari; T Mori; K Nagai; I Nakamura; H A Neal; B Nellen; R Nisius; S W O'Neale; F G Oakham; F Odorici; H O Ögren; M J Oreglia; S Orito; J Pálinkás; G Pásztor; J R Pater; G N Patrick; J Patt; R Pérez-Ochoa; S Petzold; P Pfeifenschneider; J E Pilcher; James L Pinfold; D E Plane; P R Poffenberger; J Polok; M B Przybycien; C Rembser; Hartmut Rick; S Robertson; S A Robins; N L Rodning; J M Roney; K Roscoe; A M Rossi; Y Rozen; K Runge; O Runólfsson; D R Rust; K Sachs; T Saeki; O Sahr; W M Sang; E Sarkisyan-Grinbaum; C Sbarra; A D Schaile; O Schaile; F Scharf; P Scharff-Hansen; J Schieck; B Schmitt; S Schmitt; A Schöning; M Schröder; M Schumacher; C Schwick; W G Scott; R Seuster; T G Shears; B C Shen; C H Shepherd-Themistocleous; P Sherwood; G P Siroli; A Sittler; A Skuja; A M Smith; G A Snow; Randall J Sobie; S Söldner-Rembold; S Spagnolo; M Sproston; A Stahl; K Stephens; J Steuerer; K Stoll; D Strom; R Ströhmer; B Surrow; S D Talbot; S Tanaka; P Taras; S Tarem; R Teuscher; M Thiergen; J Thomas; M A Thomson; E Von Törne; E Torrence; S Towers; I Trigger; Z L Trócsányi; E Tsur; A S Turcot; M F Turner-Watson; I Ueda; R Van Kooten; P Vannerem; M Verzocchi; H Voss; F Wäckerle; A Wagner; C P Ward; D R Ward; P M Watkins; A T Watson; N K Watson; P S Wells; N Wermes; J S White; G W Wilson; J A Wilson; T R Wyatt; S Yamashita; G Yekutieli; V Zacek; D Zer-Zion

    1999-01-01

    The branching ratio for the decay tau->e nue nutau has been measured using Z0 decay data collected by the OPAL experiment at LEP. In total 33073 tau->e nue nutau candidates were identified from a sample of 186197 selected tau decays, giving a branching ratio of 17.81 +- 0.09(stat) +_ 0.06(sys)%. This result is combined with other measurements to test e-mu

  17. Observation of B{sup +{yields}}D*{sup 0{tau}+{nu}}{sub {tau}}and evidence for B{sup +{yields}}D{sup 0{tau}+{nu}}{sub {tau}}at Belle

    SciTech Connect

    Bozek, A.; Rozanska, M.; Kapusta, P.; Matyja, A.; Ostrowicz, W.; Stypula, J. [H. Niewodniczanski Institute of Nuclear Physics, Krakow (Poland); Adachi, I.; Higuchi, T.; Iwasaki, Y.; Kichimi, H.; Krokovny, P.; Nakao, M.; Nishida, S.; Nozaki, T.; Sakai, Y.; Schuemann, J.; Trabelsi, K.; Uehara, S.; Uno, S. [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Aihara, H. [Department of Physics, University of Tokyo, Tokyo (Japan)

    2010-10-01

    We present measurements of B{sup +{yields}}D*{sup 0{tau}+{nu}}{sub {tau}}and B{sup +{yields}}D{sup 0{tau}+{nu}}{sub {tau}}decays in a data sample of 657x10{sup 6} BB pairs collected with the Belle detector at the KEKB asymmetric-energy e{sup +}e{sup -} collider. We find 446{sub -56}{sup +58} B{sup +{yields}}D*{sup 0{tau}+{nu}}{sub {tau}}events with a significance of 8.1 standard deviations, and 146{sub -41}{sup +42} B{sup +{yields}}D{sup 0{tau}+{nu}}{sub {tau}}events with a significance of 3.5 standard deviations. The latter signal provides the first evidence for this decay mode. The measured branching fractions are B(B{sup +{yields}}D*{sup 0{tau}+{nu}}{sub {tau}})=(2.12{sub -0.27}{sup +0.28}(stat){+-}0.29(syst))% and B(B{sup +{yields}}D{sup 0{tau}+{nu}}{sub {tau}})=(0.77{+-}0.22(stat){+-}0.12(syst))%.

  18. The Dipion Mass Spectrum In e+e- Annihilation and tau Decay: A Dynamical (rho0, omega, phi) Mixing Approach

    E-print Network

    M. Benayoun; P. David; L. DelBuono; O. Leitner; H. B. O'Connell

    2008-03-18

    We readdress the problem of finding a simultaneous description of the pion form factor data in e+e- annihilations and in tau decays. For this purpose, we work in the framework of the Hidden Local Symmetry (HLS) Lagrangian and modify the vector meson mass term by including the pion and kaon loop contributions. This leads us to define the physical rho, omega and phi fields as linear combinations of their ideal partners, with coefficients being meromorphic functions of s, the square of the 4--momentum flowing into the vector meson lines. This allows us to define a dynamical, i.e. s-dependent, vector meson mixing scheme. The model is overconstrained by extending the framework in order to include the description of all meson radiative (V P gamma and P gamma gamma couplings) and leptonic (Ve+e- couplings) decays and also the isospin breaking (omega/ phi --> pi+ pi-) decay modes. The model provides a simultaneous, consistent and good description of the e+e- and tau dipion spectra. The expression for pion form factor in the latter case is derived from those in the former case by switching off the isospin breaking effects specific to e+e- and switching on those for tau decays. Besides, the model also provides a good account of all decay modes of the form V P gamma, Pgamma gamma as well as the isospin breaking decay modes. It leads us to propose new reference values for the rho^0 --> e+ e- and omega --> pi+ pi- partial widths which are part of our description of the pion form factor. Other topics (phi --> K anti K, the rho meson mass and width parameters) are briefly discussed. Therefore, we confirm the 3.3 sigma discrepancy between the theoretical estimate of a_mu based on e+e- and its direct BNL measurement.

  19. Improved $\\tau$-weapons for Higgs hunting

    E-print Network

    Barenboim, G; López-Ibáñez, M L; Vives, O

    2013-01-01

    In this work, we use the results from Higgs searches in the $\\gamma\\gamma$ and $\\tau\\tau$ decay channels at LHC and indirect bounds as BR$(B \\to X_s \\gamma)$ to constrain the parameter space of a generic MSSM Higgs sector. In particular, we include the latest CMS results that look for additional Higgs states with masses up to 1 TeV. We show that the $\\tau \\tau$ channel is the best and most accurate weapon in the hunt for new Higgs states beyond the Standard Model. We obtain that present experimental results rule out additional neutral Higgs bosons in a generic MSSM below 300 GeV for any value of $\\tan \\beta$ and, for instance, values of $\\tan \\beta$ above 30 are only possible for Higgs masses above 600 GeV. ATLAS stored data has the potential to render this bound obsolete in the near future.

  20. Search for Second-Class Currents in tau- -> omega.pi-.nu_tau

    SciTech Connect

    Aubert, B.

    2009-04-22

    We report an analysis of {tau}{sup -} decaying into {omega}{pi}{sup -} {nu}{sub {tau}} with {omega} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup 0} using a data sample containing nearly 320 million {tau} pairs collected with the BABAR detector at the PEP-II B-Factory. We find no evidence for second-class currents and we set an upper limit of 0.69% at 90% confidence level for the fraction of second-class currents in this decay mode.

  1. Search for Neutral Minimal Supersymmetric Standard Model Higgs Bosons Decaying to Tau Pairs in pp Collisions at sqrt[s]=7??TeV

    SciTech Connect

    Chatrchyan, Serguei; et al.

    2011-06-01

    A search for neutral MSSM Higgs bosons in pp collisions at the LHC at a center-of-mass energy of 7 TeV is presented. The results are based on a data sample corresponding to an integrated luminosity of 36 inverse picobarns recorded by the CMS experiment. The search uses decays of the Higgs bosons to tau pairs. No excess is observed in the tau-pair invariant-mass spectrum. The resulting upper limits on the Higgs boson production cross section times branching fraction to tau pairs, as a function of the pseudoscalar Higgs boson mass, yield stringent new bounds in the MSSM parameter space.

  2. A study of w boson decay charge asymmetry using hadronic tau decays in proton - anti-proton collisions at {radical}s = 1.8 TeV

    SciTech Connect

    E.W Kuns

    2002-10-18

    This dissertation presents a measurement of the tau charge asymmetry in events where the taus are produced by W decays. This charge asymmetry appears as different rapidity distributions for positive and negative taus. Two competing effects generate tau charge asymmetry. The production mechanism for the W gauge boson generates a charge asymmetry which is a function of the ratio of parton distribution functions, d(x)=u(x), measured at x {approx} M{sub W}/{radical}s. This is the dominant effect for tau charge asymmetry at small rapidity. At higher rapidity, however, the competing charge asymmetry from parity violation in W decay to taus becomes dominant. This tau asymmetry measurement is consistent with the Standard Model with a x{sup 2} per degree of freedom equal to 2.5 for 4 degrees of freedom when the asymmetry measurement is folded about y = 0, taking advantage of the CP symmetry of the underlying physics, and 8.9 for 8 degrees of freedom when it is not. This measurement introduces some methods and variables of interest to future analyses using hadronic decay modes of taus. This work was done using the CDF detector in {bar p}p collisions at {radical} = 1.8 TeV at Fermilab's Tevatron accelerator.

  3. Study of Top-Quark Production and Decays involving a Tau Lepton at CDF and Limits on a Charged-Higgs Boson Contribution

    E-print Network

    CDF Collaboration; T. Aaltonen; S. Amerio; D. Amidei; A. Anastassov; A. Annovi; J. Antos; G. Apollinari; J. A. Appel; T. Arisawa; A. Artikov; J. Asaadi; W. Ashmanskas; B. Auerbach; A. Aurisano; F. Azfar; W. Badgett; T. Bae; A. Barbaro-Galtieri; V. E. Barnes; B. A. Barnett; P. Barria; P. Bartos; M. Bauce; F. Bedeschi; S. Behari; G. Bellettini; J. Bellinger; D. Benjamin; A. Beretvas; A. Bhatti; K. R. Bland; B. Blumenfeld; A. Bocci; A. Bodek; D. Bortoletto; J. Boudreau; A. Boveia; L. Brigliadori; C. Bromberg; E. Brucken; J. Budagov; H. S. Budd; K. Burkett; G. Busetto; P. Bussey; P. Butti; A. Buzatu; A. Calamba; S. Camarda; M. Campanelli; F. Canelli; B. Carls; D. Carlsmith; R. Carosi; S. Carrillo; B. Casal; M. Casarsa; A. Castro; P. Catastini; D. Cauz; V. Cavaliere; M. Cavalli-Sforza; A. Cerri; L. Cerrito; Y. C. Chen; M. Chertok; G. Chiarelli; G. Chlachidze; K. Cho; D. Chokheli; A. Clark; C. Clarke; M. E. Convery; J. Conway; M. Corbo; M. Cordelli; C. A. Cox; D. J. Cox; M. Cremonesi; D. Cruz; J. Cuevas; R. Culbertson; N. d'Ascenzo; M. Datta; P. de Barbaro; L. Demortier; L. Marchese; M. Deninno; F. Devoto; M. D'Errico; A. Di Canto; B. Di Ruzza; J. R. Dittmann; M. D'Onofrio; S. Donati; M. Dorigo; A. Driutti; K. Ebina; R. Edgar; A. Elagin; R. Erbacher; S. Errede; B. Esham; S. Farrington; J. P. Fernández Ramos; R. Field; G. Flanagan; R. Forrest; M. Franklin; J. C. Freeman; H. Frisch; Y. Funakoshi; C. Galloni; A. F. Garfinkel; P. Garosi; H. Gerberich; E. Gerchtein; S. Giagu; V. Giakoumopoulou; K. Gibson; C. M. Ginsburg; N. Giokaris; P. Giromini; G. Giurgiu; V. Glagolev; D. Glenzinski; M. Gold; D. Goldin; A. Golossanov; G. Gomez; G. Gomez-Ceballos; M. Goncharov; O. González López; I. Gorelov; A. T. Goshaw; K. Goulianos; E. Gramellini; S. Grinstein; C. Grosso-Pilcher; R. C. Group; J. Guimaraes da Costa; S. R. Hahn; J. Y. Han; F. Happacher; K. Hara; M. Hare; R. F. Harr; T. Harrington-Taber; K. Hatakeyama; C. Hays; J. Heinrich; M. Herndon; A. Hocker; Z. Hong; W. Hopkins; S. Hou; R. E. Hughes; U. Husemann; M. Hussein; J. Huston; G. Introzzi; M. Iori; A. Ivanov; E. James; D. Jang; B. Jayatilaka; E. J. Jeon; S. Jindariani; M. Jones; K. K. Joo; S. Y. Jun; T. R. Junk; M. Kambeitz; T. Kamon; P. E. Karchin; A. Kasmi; Y. Kato; W. Ketchum; J. Keung; B. Kilminster; D. H. Kim; H. S. Kim; J. E. Kim; M. J. Kim; S. B. Kim; S. H. Kim; Y. K. Kim; Y. J. Kim; N. Kimura; M. Kirby; K. Knoepfel; K. Kondo; D. J. Kong; J. Konigsberg; A. V. Kotwal; M. Kreps; J. Kroll; M. Kruse; T. Kuhr; M. Kurata; A. T. Laasanen; S. Lammel; M. Lancaster; K. Lannon; G. Latino; H. S. Lee; J. S. Lee; S. Leo; S. Leone; J. D. Lewis; A. Limosani; E. Lipeles; A. Lister; H. Liu; Q. Liu; T. Liu; S. Lockwitz; A. Loginov; A. Lucà; D. Lucchesi; J. Lueck; P. Lujan; P. Lukens; G. Lungu; J. Lys; R. Lysak; R. Madrak; P. Maestro; S. Malik; G. Manca; A. Manousakis-Katsikakis; F. Margaroli; P. Marino; M. Martínez; K. Matera; M. E. Mattson; A. Mazzacane; P. Mazzanti; R. McNulty; A. Mehta; P. Mehtala; C. Mesropian; T. Miao; D. Mietlicki; A. Mitra; H. Miyake; S. Moed; N. Moggi; C. S. Moon; R. Moore; M. J. Morello; A. Mukherjee; Th. Muller; P. Murat; M. Mussini; J. Nachtman; Y. Nagai; J. Naganoma; I. Nakano; A. Napier; J. Nett; C. Neu; T. Nigmanov; L. Nodulman; S. Y. Noh; O. Norniella; L. Oakes; S. H. Oh; Y. D. Oh; I. Oksuzian; T. Okusawa; R. Orava; L. Ortolan; C. Pagliarone; E. Palencia; P. Palni; V. Papadimitriou; W. Parker; G. Pauletta; M. Paulini; C. Paus; T. J. Phillips; G. Piacentino; E. Pianori; J. Pilot; K. Pitts; C. Plager; L. Pondrom; S. Poprocki; K. Potamianos; F. Prokoshin; A. Pranko; F. Ptohos; G. Punzi; N. Ranjan; I. Redondo Fernández; P. Renton; M. Rescigno; F. Rimondi; L. Ristori; C. Rizzi; A. Robson; T. Rodriguez; S. Rolli; M. Ronzani; R. Roser; J. L. Rosner; F. Ruffini; A. Ruiz; J. Russ; V. Rusu; W. K. Sakumoto; Y. Sakurai; L. Santi; K. Sato; V. Saveliev; A. Savoy-Navarro; P. Schlabach; E. E. Schmidt; T. Schwarz; L. Scodellaro; F. Scuri; S. Seidel; Y. Seiya; A. Semenov; F. Sforza; S. Z. Shalhout; T. Shears; P. F. Shepard; M. Shimojima; M. Shochet; I. Shreyber-Tecker; A. Simonenko; K. Sliwa; J. R. Smith; F. D. Snider; V. Sorin; H. Song; M. Stancari; R. St. Denis; D. Stentz; J. Strologas; Y. Sudo; A. Sukhanov; I. Suslov; K. Takemasa; Y. Takeuchi; J. Tang; M. Tecchio; P. K. Teng; J. Thom; E. Thomson; V. Thukral; D. Toback; S. Tokar; K. Tollefson; T. Tomura; D. Tonelli; S. Torre; D. Torretta; P. Totaro; M. Trovato; F. Ukegawa; S. Uozumi; F. Vázquez; G. Velev; C. Vellidis; C. Vernieri; M. Vidal; R. Vilar; J. Vizán; M. Vogel; G. Volpi; P. Wagner; R. Wallny; S. M. Wang; D. Waters; W. C. Wester III; D. Whiteson; A. B. Wicklund; S. Wilbur; H. H. Williams; J. S. Wilson; P. Wilson; B. L. Winer; P. Wittich; S. Wolbers; H. Wolfe; T. Wright; X. Wu; Z. Wu; K. Yamamoto; D. Yamato; T. Yang; U. K. Yang; Y. C. Yang; W. -M. Yao; G. P. Yeh; K. Yi; J. Yoh; K. Yorita; T. Yoshida

    2014-04-22

    We present an analysis of top-antitop quark production and decay into a tau lepton, tau neutrino, and bottom quark using data from $9 {\\rm fb}^{-1}$ of integrated luminosity at the Collider Detector at Fermilab. Dilepton events, where one lepton is an energetic electron or muon and the other a hadronically-decaying tau lepton, originating from proton-antiproton collisions at $\\sqrt{s} = 1.96 TeV$ are used. A top-antitop quark production cross section of $8.1 \\pm 2.1 {\\rm pb}$ is measured, assuming standard-model top-quark decays. By separately identifying for the first time the single-tau and the ditau components, we measure the branching fraction of the top quark into tau lepton, tau neutrino, and bottom quark to be $(9.6 \\pm 2.8) %$. The branching fraction of top-quark decays into a charged Higgs boson and a bottom quark, which would imply violation of lepton universality, is limited to be less than $5.9%$ at $95%$ confidence level.

  4. Study of top quark production and decays involving a tau lepton at CDF and limits on a charged Higgs boson contribution

    NASA Astrophysics Data System (ADS)

    Aaltonen, T.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J. A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Auerbach, B.; Aurisano, A.; Azfar, F.; Badgett, W.; Bae, T.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauce, M.; Bedeschi, F.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Bland, K. R.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brigliadori, L.; Bromberg, C.; Brucken, E.; Budagov, J.; Budd, H. S.; Burkett, K.; Busetto, G.; Bussey, P.; Butti, P.; Buzatu, A.; Calamba, A.; Camarda, S.; Campanelli, M.; Canelli, F.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Cho, K.; Chokheli, D.; Clark, A.; Clarke, C.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Cremonesi, M.; Cruz, D.; Cuevas, J.; Culbertson, R.; d'Ascenzo, N.; Datta, M.; de Barbaro, P.; Demortier, L.; Deninno, M.; D'Errico, M.; Devoto, F.; Di Canto, A.; Di Ruzza, B.; Dittmann, J. R.; Donati, S.; D'Onofrio, M.; Dorigo, M.; Driutti, A.; Ebina, K.; Edgar, R.; Elagin, A.; Erbacher, R.; Errede, S.; Esham, B.; Farrington, S.; Fernández Ramos, J. P.; Field, R.; Flanagan, G.; Forrest, R.; Franklin, M.; Freeman, J. C.; Frisch, H.; Funakoshi, Y.; Galloni, C.; Garfinkel, A. F.; Garosi, P.; Gerberich, H.; Gerchtein, E.; Giagu, S.; Giakoumopoulou, V.; Gibson, K.; Ginsburg, C. M.; Giokaris, N.; Giromini, P.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldin, D.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González López, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gramellini, E.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Guimaraes da Costa, J.; Hahn, S. R.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, M.; Harr, R. F.; Harrington-Taber, T.; Hatakeyama, K.; Hays, C.; Heinrich, J.; Herndon, M.; Hocker, A.; Hong, Z.; Hopkins, W.; Hou, S.; Hughes, R. E.; Husemann, U.; Hussein, M.; Huston, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jindariani, S.; Jones, M.; Joo, K. K.; Jun, S. Y.; Junk, T. R.; Kambeitz, M.; Kamon, T.; Karchin, P. E.; Kasmi, A.; Kato, Y.; Ketchum, W.; Keung, J.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. H.; Kim, S. B.; Kim, Y. J.; Kim, Y. K.; Kimura, N.; Kirby, M.; Knoepfel, K.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Kruse, M.; Kuhr, T.; Kurata, M.; Laasanen, A. T.; Lammel, S.; Lancaster, M.; Lannon, K.; Latino, G.; Lee, H. S.; Lee, J. S.; Leo, S.; Leone, S.; Lewis, J. D.; Limosani, A.; Lipeles, E.; Lister, A.; Liu, H.; Liu, Q.; Liu, T.; Lockwitz, S.; Loginov, A.; Lucchesi, D.; Lucà, A.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; Madrak, R.; Maestro, P.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Marchese, L.; Margaroli, F.; Marino, P.; Martínez, M.; Matera, K.; Mattson, M. E.; Mazzacane, A.; Mazzanti, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Mesropian, C.; Miao, T.; Mietlicki, D.; Mitra, A.; Miyake, H.; Moed, S.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M. J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Nigmanov, T.; Nodulman, L.; Noh, S. Y.; Norniella, O.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Ortolan, L.; Pagliarone, C.; Palencia, E.; Palni, P.; Papadimitriou, V.; Parker, W.; Pauletta, G.; Paulini, M.; Paus, C.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pilot, J.; Pitts, K.; Plager, C.; Pondrom, L.; Poprocki, S.; Potamianos, K.; Pranko, A.; Prokoshin, F.; Ptohos, F.; Punzi, G.; Ranjan, N.; Redondo Fernández, I.; Renton, P.; Rescigno, M.; Rimondi, F.; Ristori, L.; Rizzi, C.; Robson, A.; Rodriguez, T.; Rolli, S.; Ronzani, M.; Roser, R.; Rosner, J. L.; Ruffini, F.; Ruiz, A.; Russ, J.; Rusu, V.; Sakumoto, W. K.; Sakurai, Y.; Santi, L.; Sato, K.; Saveliev, V.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, E. E.; Schwarz, T.; Scodellaro, L.; Scuri, F.; Seidel, S.; Seiya, Y.; Semenov, A.; Sforza, F.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shochet, M.; Shreyber-Tecker, I.; Simonenko, A.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Song, H.; Sorin, V.; St. Denis, R.; Stancari, M.; Stentz, D.; Strologas, J.; Sudo, Y.; Sukhanov, A.; Suslov, I.; Takemasa, K.; Takeuchi, Y.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thomson, E.; Thukral, V.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Trovato, M.; Ukegawa, F.; Uozumi, S.; Velev, G.

    2014-05-01

    We present an analysis of top-antitop quark production and decay into a tau lepton, tau neutrino, and bottom quark using data from 9 fb-1 of integrated luminosity at the Collider Detector at Fermilab. Dilepton events, where one lepton is an energetic electron or muon and the other a hadronically decaying tau lepton, originating from proton-antiproton collisions at ?s =1.96 TeV, are used. A top-antitop quark production cross section of 8.1±2.1 pb is measured, assuming standard-model top quark decays. By separately identifying for the first time the single-tau and the ditau components, we measure the branching fraction of the top quark into the tau lepton, tau neutrino, and bottom quark to be (9.6±2.8)%. The branching fraction of top quark decays into a charged Higgs boson and a bottom quark, which would imply violation of lepton universality, is limited to be less than 5.9% at a 95% confidence level [for B(H-???¯)=1].

  5. QCD tests from e+e- -> I = 1 hadrons data and implication on the value of alphaS from tau-decays

    Microsoft Academic Search

    S. Narison; Eugene Bataillon

    1995-01-01

    We re-examine the estimate of alphaS and of the QCD condensates from e+e- -> I = 1 hadrons data. We conclude thate+e- at low energies gives a value of Lambda compatible with the one from LEP and from tau inclusive decay. Using a tau-like inclusive process and QCD spectral sum rules, we estimate the size of the D = 4

  6. HST\\/NICMOS Imaging of HL Tau and XZ Tau

    Microsoft Academic Search

    A. S. Cotera; E. Young; Hua Chen

    1999-01-01

    We have obtained HST\\/NICMOS images of HL Tau and XZ Tau using Camera 2 with a nominal plate scale of 0.0755+\\/-0.005 arcsec\\/pixel. We selected the filter combination F110W, F160W, F187N, F204M and F212N, to investigate the NIR continuum emission, Paalpha and H_2 features within the region. The data was reduced using the NICRED package and software developed by the NICMOS

  7. High Mass Tau Tau in CDF Run 2 Rutgers University

    E-print Network

    Fermilab

    ID 10 All channels Ã? 6 All channels Jet fake rate 20 All channels 15 #12;Result 100 200 300 400 500 Shrinking Cone 4 #12;Tau ID Efficiency & Jet Misid. Rate Visible Energy (GeV) 0 50 100 150 200 Efficiency(%) 0 20 40 60 CDF Run 2 Preliminary Tau Efficiency (Rec + ID) Jet Cluster Energy (GeV) 0 50 100 150 200

  8. Enhanced Higgs to $\\tau^+\\tau^-$ Searches with Deep Learning

    E-print Network

    Baldi, Pierre; Whiteson, Daniel

    2014-01-01

    The Higgs boson is thought to provide the interaction that imparts mass to the fundamental fermions, but while measurements at the Large Hadron Collider (LHC) are consistent with this hypothesis, current analysis techniques lack the statistical power to cross the traditional 5$\\sigma$ significance barrier without more data. \\emph{Deep learning} techniques have the potential to increase the statistical power of this analysis by \\emph{automatically} learning complex, high-level data representations. In this work, deep neural networks are used to detect the decay of the Higgs to a pair of tau leptons. A Bayesian optimization algorithm is used to tune the network architecture and training algorithm hyperparameters, resulting in a deep network of eight non-linear processing layers that improves upon the performance of shallow classifiers even without the use of features specifically engineered by physicists for this application. The improvement in discovery significance is equivalent to an increase in the accumula...

  9. Extracellular Tau Levels Are Influenced by Variability in Tau That Is Associated with Tauopathies*

    PubMed Central

    Karch, Celeste M.; Jeng, Amanda T.; Goate, Alison M.

    2012-01-01

    Tauopathies are a class of neurodegenerative diseases marked by intracellular aggregates of hyperphosphorylated Tau. These diseases may occur by sporadic mechanisms in which genetic variants represent risk factors for disease, as is the case in Alzheimer disease (AD). In AD, cerebrospinal fluid (CSF) levels of soluble Tau/pTau-181 are higher in cases compared with controls. A subset of frontotemporal dementia (FTD) cases occur by a familial mechanism in which MAPT, the gene that encodes Tau, mutations are dominantly inherited. In symptomatic FTD patients expressing a MAPT mutation, CSF Tau levels are slightly elevated but are significantly lower than in AD patients. We sought to model CSF Tau changes by measuring extracellular Tau in cultured cells. Full-length, monomeric extracellular total Tau and pTau-181 were detectable in human neuroblastoma cells expressing endogenous Tau, in human non-neuronal cells overexpressing wild-type Tau, and in mouse cortical neurons. Tau isoforms influence the rate of Tau release, whereby the N terminus (exons 2/3) and microtubule binding repeat length contribute to Tau release from the cell. Compared with cells overexpressing wild-type Tau, cells overexpressing FTD-associated MAPT mutations produce significantly less extracellular total Tau without altering intracellular total Tau levels. This study demonstrates that cells actively release Tau in the absence of disease or toxicity, and Tau release is modified by changes in the Tau protein that are associated with tauopathies. PMID:23105105

  10. Tau aggregates as immunotherapeutic targets.

    PubMed

    Castillo-Carranza, Diana L; Lasagna-Reeves, Cristian A; Kayed, Rakez

    2013-01-01

    Pathological aggregation of the microtubule-associated protein tau and accumulation of neurofibrillary tangles (NFT) and other inclusions containing hyperphosphorylated tau are defining histopathological features of Alzheimer disease (AD) and many other neurodegenerative diseases collectively known as tauopathies. The toxicity of tau aggregates has been demonstrated in vitro and in vivo; thus, their clearance by immunotherapy holds clinical promise. Published studies, which are limited in number, have exclusively focused on the clearance of hyperphosphorylated large tau aggregates, e.g., NFT. However, recent studies using human tissues and mouse models have questioned the toxicity and the presumed role of NFT in the progression of tauopathies and challenged the view of tangles as toxic species in the brain. Together, these novel studies have demonstrated that prefilamentous tau oligomers rather than NFT play a crucial role in these disorders. Here, we summarize recent advances in this new field, highlight the role of tau oligomers and their potential as a therapeutic target for the treatment of AD and other neurodegenerative tauopathies, and discuss the challenges that lie ahead. PMID:23277060

  11. High-statistics study of the {tau}{sup -}{yields}{pi}{sup -}{pi}{sup 0}{nu}{sub {tau}} decay

    SciTech Connect

    Fujikawa, M.; Hayashii, H.; Kataoka, S. U.; Miyabayashi, K.; Noguchi, S.; Sekiya, A. [Nara Women's University, Nara (Japan); Eidelman, S.; Arinstein, K.; Aulchenko, V.; Bedny, I.; Bondar, A.; Epifanov, D.; Gabyshev, N.; Kuzmin, A.; Poluektov, A.; Shebalin, V.; Shwartz, B.; Usov, Y.; Vinokurova, A.; Zhilich, V. [Budker Institute of Nuclear Physics, Novosibirsk (Russian Federation)] (and others)

    2008-10-01

    We report a high-statistics measurement of the branching fraction for {tau}{sup -}{yields}{pi}{sup -}{pi}{sup 0}{nu}{sub {tau}} and the invariant mass spectrum of the produced {pi}{sup -}{pi}{sup 0} system using 72.2 fb{sup -1} of data recorded with the Belle detector at the KEKB asymmetric-energy e{sup +}e{sup -} collider. The branching fraction obtained is (25.24{+-}0.01{+-}0.39)%, where the first error is statistical and the second is systematic. The unfolded {pi}{sup -}{pi}{sup 0} mass spectrum is used to determine resonance parameters for the {rho}(770), {rho}{sup '}(1450), and {rho}{sup ''}(1700) mesons. We also use this spectrum to estimate the hadronic (2{pi}) contribution to the anomalous magnetic moment of the muon (a{sub {mu}}{sup {pi}}{sup {pi}}). Our result for a{sub {mu}}{sup {pi}}{sup {pi}} integrated over the mass range {radical}(s)=2m{sub {pi}}-1.8 GeV/c{sup 2} is a{sub {mu}}{sup {pi}}{sup {pi}}=(523.5{+-}1.5(exp){+-}2.6(Br){+-}2.5(isospin))x10{sup -10}, where the first error is due to the experimental uncertainties, the second is due to the uncertainties in the branching fractions, and the third is due to the uncertainties in the isospin-violating corrections.

  12. Insulin dysfunction and Tau pathology

    PubMed Central

    El Khoury, Noura B.; Gratuze, Maud; Papon, Marie-Amélie; Bretteville, Alexis; Planel, Emmanuel

    2013-01-01

    The neuropathological hallmarks of Alzheimer's disease (AD) include senile plaques of ?-amyloid (A?) peptides (a cleavage product of the Amyloid Precursor Protein, or APP) and neurofibrillary tangles (NFT) of hyperphosphorylated Tau protein assembled in paired helical filaments (PHF). NFT pathology is important since it correlates with the degree of cognitive impairment in AD. Only a small proportion of AD is due to genetic variants, whereas the large majority of cases (~99%) is late onset and sporadic in origin. The cause of sporadic AD is likely to be multifactorial, with external factors interacting with biological or genetic susceptibilities to accelerate the manifestation of the disease. Insulin dysfunction, manifested by diabetes mellitus (DM) might be such factor, as there is extensive data from epidemiological studies suggesting that DM is associated with an increased relative risk for AD. Type 1 diabetes (T1DM) and type 2 diabetes (T2DM) are known to affect multiple cognitive functions in patients. In this context, understanding the effects of diabetes on Tau pathogenesis is important since Tau pathology show a strong relationship to dementia in AD, and to memory loss in normal aging and mild cognitive impairment. Here, we reviewed preclinical studies that link insulin dysfunction to Tau protein pathogenesis, one of the major pathological hallmarks of AD. We found more than 30 studies reporting Tau phosphorylation in a mouse or rat model of insulin dysfunction. We also payed attention to potential sources of artifacts, such as hypothermia and anesthesia, that were demonstrated to results in Tau hyperphosphorylation and could major confounding experimental factors. We found that very few studies reported the temperature of the animals, and only a handful did not use anesthesia. Overall, most published studies showed that insulin dysfunction can promote Tau hyperphosphorylation and pathology, both directly and indirectly, through hypothermia. PMID:24574966

  13. Improved Measurement of Absolute Branching Fraction of Ds to tau nu

    E-print Network

    CLEO Collaboration; P. U. E. Onyisi

    2009-03-11

    We have studied the leptonic decay D^+_s to tau^+ nu_tau, via the decay channel tau^+ to e^+ nu_e anti-nu_tau, using a sample of tagged D_s^+ decays collected near the D^*_s D_s peak production energy in e^+ e^- collisions with the CLEO-c detector. We obtain B(D^+_s to tau^+ nu_tau) = (5.30 +- 0.47 +- 0.22) % and determine the decay constant f_Ds = (252.5 +- 11.1 +- 5.2) MeV, where the first uncertainties are statistical and the second are systematic.

  14. Measurements of the top anti-top production cross section and top quark mass in the hadronically decaying tau + jets decay channel at CDF

    NASA Astrophysics Data System (ADS)

    Hare, Daryl Curtis

    In this thesis, we present the first exclusive observation of the tt¯ ? hadronic tau + jets decay channel. Using these events, we measure the tt¯ pair production cross section and the top quark mass in 2.2 fb-1 of data collected with the Collider Detector at Fermilab (CDF). The Tevatron accelerator at Fermilab provides collisions of protons and anti-protons at a center-of-mass energy of s = 1.96 TeV and is one of only two accelerators in the world with enough energy to produce top quarks. With a branching fraction of nearly 10%, the hadronic tau + jets decay channel is the third largest tt¯ decay mode, and it has only been minimally explored. This the first measurement of the tt¯ pair production cross section in this decay channel at CDF and the first measurement of the top quark mass in this decay channel in the world. The analysis introduces a new method to recover the total momentum of the nu produced in the tau decay and an artificial neural network to reduce the contribution from the largest background source, QCD multijet background. The tt¯ pair production cross section is extracted by minimizing a negative log likelihood function which compares the number of observed events to the number of expected events for a given tt¯ cross section. The top quark mass is extracted by minimizing a negative log likelihood function built from signal and background probabilities which are based on the matrix elements for tt¯ production and decay and W + 4 parton production, respectively. Using events selected with exactly 1 hadronically decaying tau, exactly 4 jets with at least 1 identified as having originated from a b quark, and large missing transverse energy, we measure the tt¯ pair production cross section to be 8.8 +/- 3.3 (stat.) +/- 2.2 (syst.) pb and the top quark mass to be 172.7 +/- 9.3 (stat.) +/- 3.7 (syst.) GeV. We find both values to be in good agreement with previous measurements in other tt¯ decay channels, and the cross section to be consistent with next-to-leading order theoretical predictions.

  15. Direct Bounds on the Tau Neutrino Mass from LEP

    NASA Astrophysics Data System (ADS)

    Passalacqua, L.

    1997-05-01

    A review of direct bounds on the mass of the tau neutrino obtained at the LEP collider is presented. In addition to published results it includes preliminary results presented at recent conferences and new results presented at the 1996 Tau Workshop. The different techniques and decay modes employed by the ALEPH, DELPHI and OPAL collaborations are compared. The impact of the theoretical modelling of tau decays is also discussed. The most stringent 95% CL limit on the tau neutrino mass is now obtained by a preliminary ALEPH analysis which combines the results from ? ? 5? ±(? 0)? ? and ? ? 3? ± ? ? decays. This bound constraints the mass of the tau neutrino below 18.2 MeV/c 2.

  16. Tau trigger, reconstruction and identification at CMS

    NASA Astrophysics Data System (ADS)

    Calabria, Cesare

    2014-08-01

    The importance of tau leptons in new physics searches at the LHC led the CMS collaboration to design a specific algorithm, the Hadron Plus Strip (HPS) algorithm, for the reconstruction and identification of taus decaying hadronically (?had). The HPS algorithm makes use of a particle description of the event to identify hadronic decay modes of ? leptons through the reconstruction of intermediate resonances. It also provides discriminators against potentially large backgrounds from quarks, gluons and light leptons (electrons and muons). Moreover, thanks to the particle event reconstruction avalaible in CMS, a fast online hadronic tau reconstruction can be performed allowing the development of efficient tau trigger selections which allow to perform a broad range of physics analysis. This report describes the ?had reconstruction and identification of the HPS algorithm and its performances, studied in simulated Z ? ?? events and in samples of proton-proton collision data collected during 2011 and 2012 data-taking at ?{ s} = 7 TeV and 8 TeV , respectively. Finally, the performance of the tau trigger selections is presented.

  17. Measurement of the tau lepton polarisation at LEP2

    NASA Astrophysics Data System (ADS)

    DELPHI Collaboration; Abdallah, J.; Abreu, P.; Adam, W.; Adzic, P.; Albrecht, T.; Alemany-Fernandez, R.; Allmendinger, T.; Allport, P. P.; Amaldi, U.; Amapane, N.; Amato, S.; Anashkin, E.; Andreazza, A.; Andringa, S.; Anjos, N.; Antilogus, P.; Apel, W.-D.; Arnoud, Y.; Ask, S.; Asman, B.; Augustin, J. E.; Augustinus, A.; Baillon, P.; Ballestrero, A.; Bambade, P.; Barbier, R.; Bardin, D.; Barker, G. J.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.-H.; Begalli, M.; Behrmann, A.; Ben-Haim, E.; Benekos, N.; Benvenuti, A.; Berat, C.; Berggren, M.; Bertrand, D.; Besancon, M.; Besson, N.; Bloch, D.; Blom, M.; Bluj, M.; Bonesini, M.; Boonekamp, M.; Booth, P. S. L.; Borisov, G.; Botner, O.; Bouquet, B.; Bowcock, T. J. V.; Boyko, I.; Bracko, M.; Brenner, R.; Brodet, E.; Bruckman, P.; Brunet, J. M.; Buschbeck, B.; Buschmann, P.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Castro, N.; Cavallo, F.; Chapkin, M.; Charpentier, Ph.; Checchia, P.; Chierici, R.; Chliapnikov, P.; Chudoba, J.; Chung, S. U.; Cieslik, K.; Collins, P.; Contri, R.; Cosme, G.; Cossutti, F.; Costa, M. J.; Crennell, D.; Cuevas, J.; D'Hondt, J.; da Silva, T.; da Silva, W.; Dedovich, D.; Ricca, G. Della; de Angelis, A.; de Boer, W.; de Clercq, C.; de Lotto, B.; de Maria, N.; de Min, A.; de Paula, L.; di Ciaccio, L.; di Simone, A.; Doroba, K.; Drees, J.; Eigen, G.; Ekelof, T.; Ellert, M.; Elsing, M.; Santo, M. C. Espirito; Fanourakis, G.; Fassouliotis, D.; Feindt, M.; Fernandez, J.; Ferrer, A.; Ferro, F.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fulda-Quenzer, F.; Fuster, J.; Gandelman, M.; Garcia, C.; Gavillet, Ph.; Gazis, E.; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Graziani, E.; Grosdidier, G.; Grzelak, K.; Guy, J.; Haag, C.; Hallgren, A.; Hamacher, K.; Hamilton, K.; Haug, S.; Hauler, F.; Hedberg, V.; Hennecke, M.; Herr, H.; Hoffman, J.; Holmgren, S.-O.; Holt, P. J.; Houlden, M. A.; Jackson, J. N.; Jarlskog, G.; Jarry, P.; Jeans, D.; Johansson, E. K.; Jonsson, P.; Joram, C.; Jungermann, L.; Kapusta, F.; Katsanevas, S.; Katsoufis, E.; Kernel, G.; Kersevan, B. P.; Kerzel, U.; King, B. T.; Kjaer, N. J.; Kluit, P.; Kokkinias, P.; Kourkoumelis, C.; Kouznetsov, O.; Krumstein, Z.; Kucharczyk, M.; Lamsa, J.; Leder, G.; Ledroit, F.; Leinonen, L.; Leitner, R.; Lemonne, J.; Lepeltier, V.; Lesiak, T.; Liebig, W.; Liko, D.; Lipniacka, A.; Lopes, J. H.; Lopez, J. M.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Malek, A.; Maltezos, S.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.-C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Mazzucato, F.; Mazzucato, M.; Nulty, R. Mc; Meroni, C.; Migliore, E.; Mitaroff, W.; Mjoernmark, U.; Moa, T.; Moch, M.; Moenig, K.; Monge, R.; Montenegro, J.; Moraes, D.; Moreno, S.; Morettini, P.; Mueller, U.; Muenich, K.; Mulders, M.; Mundim, L.; Murray, W.; Muryn, B.; Myatt, G.; Myklebust, T.; Nassiakou, M.; Navarria, F.; Nawrocki, K.; Nicolaidou, R.; Nikolenko, M.; Oblakowska-Mucha, A.; Obraztsov, V.; Olshevski, A.; Onofre, A.; Orava, R.; Osterberg, K.; Ouraou, A.; Oyanguren, A.; Paganoni, M.; Paiano, S.; Palacios, J. P.; Palka, H.; Papadopoulou, Th. D.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Peralta, L.; Perepelitsa, V.; Perrotta, A.; Petrolini, A.; Piedra, J.; Pieri, L.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Poireau, V.; Pol, M. E.; Polok, G.; Pozdniakov, V.; Pukhaeva, N.; Pullia, A.; Rames, J.; Read, A.; Rebecchi, P.; Rehn, J.; Reid, D.; Reinhardt, R.; Renton, P.; Richard, F.; Ridky, J.; Rivero, M.; Rodriguez, D.; Romero, A.; Ronchese, P.; Roudeau, P.; Rovelli, T.; Ruhlmann-Kleider, V.; Ryabtchikov, D.; Sadovsky, A.; Salmi, L.; Salt, J.; Sander, C.; Savoy-Navarro, A.; Schwickerath, U.; Sekulin, R.; Siebel, M.; Sisakian, A.; Smadja, G.; Smirnova, O.; Sokolov, A.; Sopczak, A.; Sosnowski, R.; Spassov, T.; Stanitzki, M.; Stocchi, A.; Strauss, J.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Szumlak, T.; Tabarelli, T.; Tegenfeldt, F.; Timmermans, J.; Tkatchev, L.; Tobin, M.; Todorovova, S.; Tome, B.; Tonazzo, A.; Tortosa, P.; Travnicek, P.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Turluer, M.-L.; Tyapkin, I. A.; Tyapkin, P.; Tzamarias, S.; Uvarov, V.; Valenti, G.; van Dam, P.; van Eldik, J.; van Remortel, N.; van Vulpen, I.; Vegni, G.; Veloso, F.; Venus, W.; Verdier, P.; Verzi, V.; Vilanova, D.; Vitale, L.; Vrba, V.; Wahlen, H.; Washbrook, A. J.; Weiser, C.; Wicke, D.; Wickens, J.; Wilkinson, G.; Winter, M.; Witek, M.; Yushchenko, O.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zhuravlov, V.; Zimin, N. I.; Zintchenko, A.; Zupan, M.

    2008-01-01

    A first measurement of the average polarisation P of tau leptons produced in e+e- annihilation at energies significantly above the Z resonance is presented. The polarisation is determined from the kinematic spectra of tau hadronic decays. The measured value P=-0.164±0.125 is consistent with the Standard Model prediction for the mean LEP energy of 197 GeV.

  18. Estimate of the spectral classes of the T Tau type stars HL Tau and DG Tau

    SciTech Connect

    Yudin, R.V.; Miroshnichenko, A.S.

    1988-07-01

    Estimates have been made of the fundamental physical characteristics of two stars in the stage of evolution to the main sequence. The revised spectral classification for the star HL Tau has made it possible to achieve agreement with the published physical characteristics. The results of the estimates by two independent methods of the fundamental physical characteristics of the two stars in the stage of evolution to the main sequence have given consistent results. For the star HL Tau the revised spectral classification has made it possible to establish agreement for the published physical characteristics of the star. It is probable that HL Tau is a star of early spectral class and of the Ae/Be Herbig type.

  19. Tau Splicing and the Intricacies of Dementia

    PubMed Central

    Andreadis, Athena

    2011-01-01

    Tau is a microtubule associated protein that fulfills several functions critical for neuronal formation and health. Tau discharges its functions by producing multiple isoforms via regulated alternative splicing. These isoforms modulate tau function in normal brain by altering the domains of the protein, thereby influencing its localization, conformation and post-translational modifications and hence its availability and affinity for microtubules and other ligands. Disturbances in tau expression result in disruption of the neuronal cytoskeleton and formation of tau structures (neurofibrillary tangles) found in brains of dementia sufferers. More specifically, aberrations in tau splicing regulation directly cause several neurodegenerative diseases which lead to dementia. In this review, I present our cumulative knowledge of tau splicing regulation in connection with neurodegeneration and also briefly go over the still-extensive list of questions that are connected to tau (dys)function. PMID:21604267

  20. A measurement of the tau--->e- nu¯enutau branching ratio

    Microsoft Academic Search

    G. Abbiendi; K. Ackerstaff; G. Alexander; J. Allison; N. Altekamp; K. J. Anderson; S. Anderson; S. Arcelli; S. Asai; S. F. Ashby; D. Axen; G. Azuelos; A. H. Ball; E. Barberio; R. J. Barlow; R. Bartoldus; J. R. Batley; S. Baumann; J. Bechtluft; T. Behnke; K. W. Bell; G. Bella; A. Bellerive; S. Bentvelsen; S. Bethke; S. Betts; O. Biebel; A. Biguzzi; S. D. Bird; V. Blobel; I. J. Bloodworth; P. Bock; J. Böhme; D. Bonacorsi; M. Boutemeur; S. Braibant; P. Bright-Thomas; L. Brigliadori; R. M. Brown; H. J. Burckhart; P. Capiluppi; R. K. Carnegie; A. A. Carter; J. R. Carter; C. Y. Chang; D. G. Charlton; D. Chrisman; C. Ciocca; P. E. L. Clarke; E. Clay; I. Cohen; J. E. Conboy; O. C. Cooke; C. Couyoumtzelis; R. L. Coxe; M. Cuffiani; S. Dado; G. M. Dallavalle; R. Davis; S. de Jong; A. de Roeck; P. Dervan; K. Desch; B. Dienes; M. S. Dixit; J. Dubbert; E. Duchovni; G. Duckeck; I. P. Duerdoth; D. Eatough; P. G. Estabrooks; E. Etzion; F. Fabbri; M. Fanti; A. A. Faust; F. Fiedler; M. Fierro; I. Fleck; R. Folman; A. Fürtjes; D. I. Futyan; P. Gagnon; J. W. Gary; J. Gascon; S. M. Gascon-Shotkin; G. Gaycken; C. Geich-Gimbel; G. Giacomelli; P. Giacomelli; V. Gibson; W. R. Gibson; D. M. Gingrich; D. Glenzinski; J. Goldberg; W. Gorn; C. Grandi; K. Graham; E. Gross; J. Grunhaus; M. Gruwé; G. G. Hanson; M. Hansroul; M. Hapke; K. Harder; A. Harel; C. K. Hargrove; C. Hartmann; M. Hauschild; C. M. Hawkes; R. Hawkings; R. J. Hemingway; M. Herndon; G. Herten; R. D. Heuer; M. D. Hildreth; J. C. Hill; P. R. Hobson; M. Hoch; A. Hocker; K. Hoffman; R. J. Homer; A. K. Honma; D. Horváth; K. R. Hossain; R. Howard; P. Hüntemeyer; P. Igo-Kemenes; D. C. Imrie; K. Ishii; F. R. Jacob; A. Jawahery; H. Jeremie; M. Jimack; C. R. Jones; P. Jovanovic; T. R. Junk; D. Karlen; V. Kartvelishvili; K. Kawagoe; T. Kawamoto; P. I. Kayal; R. K. Keeler; R. G. Kellogg; B. W. Kennedy; D. H. Kim; A. Klier; S. Kluth; T. Kobayashi; M. Kobel; D. S. Koetke; T. P. Kokott; M. Kolrep; S. Komamiya; R. V. Kowalewski; T. Kress; P. Krieger; J. von Krogh; T. Kuhl; P. Kyberd; G. D. Lafferty; H. Landsman; D. Lanske; J. Lauber; S. R. Lautenschlager; I. Lawson; J. G. Layter; D. Lazic; A. M. Lee; D. Lellouch; J. Letts; L. Levinson; R. Liebisch; B. List; C. Littlewood; A. W. Lloyd; S. L. Lloyd; F. K. Loebinger; G. D. Long; M. J. Losty; J. Ludwig; D. Liu; A. Macchiolo; A. MacPherson; W. Mader; M. Mannelli; S. Marcellini; C. Markopoulos; A. J. Martin; J. P. Martin; G. Martinez; T. Mashimo; P. Mättig; W. J. McDonald; J. McKenna; E. A. McKigney; T. J. McMahon; R. A. McPherson; F. Meijers; S. Menke; F. S. Merritt; H. Mes; J. Meyer; A. Michelini; S. Mihara; G. Mikenberg; D. J. Miller; R. Mir; W. Mohr; A. Montanari; T. Mori; K. Nagai; I. Nakamura; H. A. Neal; B. Nellen; R. Nisius; S. W. O'Neale; F. G. Oakham; F. Odorici; H. O. Ogren; M. J. Oreglia; S. Orito; J. Pálinkás; G. Pásztor; J. R. Pater; G. N. Patrick; J. Patt; R. Perez-Ochoa; S. Petzold; P. Pfeifenschneider; J. E. Pilcher; J. Pinfold; D. E. Plane; P. Poffenberger; J. Polok; M. Przybycien; C. Rembser; H. Rick; S. Robertson; S. A. Robins; N. Rodning; J. M. Roney; K. Roscoe; A. M. Rossi; Y. Rozen; K. Runge; O. Runolfsson; D. R. Rust; K. Sachs; T. Saeki; O. Sahr; W. M. Sang; E. K. G. Sarkisyan; C. Sbarra; A. D. Schaile; O. Schaile; F. Scharf; P. Scharff-Hansen; J. Schieck; B. Schmitt; S. Schmitt; A. Schöning; M. Schröder; M. Schumacher; C. Schwick; W. G. Scott; R. Seuster; T. G. Shears; B. C. Shen; C. H. Shepherd-Themistocleous; P. Sherwood; G. P. Siroli; A. Sittler; A. Skuja; A. M. Smith; G. A. Snow; R. Sobie; S. Söldner-Rembold; S. Spagnolo; M. Sproston; A. Stahl; K. Stephens; J. Steuerer; K. Stoll; D. Strom; R. Ströhmer; B. Surrow; S. D. Talbot; S. Tanaka; P. Taras; S. Tarem; R. Teuscher; M. Thiergen; J. Thomas; M. A. Thomson; E. von Törne; E. Torrence; S. Towers; I. Trigger; Z. Trócsányi; E. Tsur; A. S. Turcot; M. F. Turner-Watson; I. Ueda; R. van Kooten; P. Vannerem; M. Verzocchi; H. Voss; F. Wäckerle; A. Wagner; C. P. Ward; D. R. Ward; P. M. Watkins; A. T. Watson; N. K. Watson; P. S. Wells; N. Wermes; J. S. White; G. W. Wilson; J. A. Wilson; T. R. Wyatt; S. Yamashita; G. Yekutieli; V. Zacek; D. Zer-Zion

    1999-01-01

    The branching ratio for the decay tau--->e- nu¯enutau has been measured using Z0 decay data collected by the OPAL experiment at LEP. In total 33 073 tau--->e- nu¯enutau candidates were identified from a sample of 186 197 selected tau decays, giving a branching ratio of B(tau--->e- nu¯enutau)=(17.81+\\/-0.09 (stat)+\\/-0.06 (syst))%. This result is combined with other measurements to test e -

  1. First measurement of sigma (p anti-p ---> Z) . Br (Z ---> tau tau) at s**(1/2) = 1.96- TeV

    SciTech Connect

    Abazov, V.M.; Abbott, B.; Abolins, M.; Acharya, B.S.; Adams, M.; Adams, T.; Agelou, M.; Agram, J.-L.; Ahn, S.H.; Ahsan, M.; Alexeev, G.D.; Alkhazov, G.; Alton, A.; Alverson, G.; Alves, G.A.; Anastasoaie, M.; Andeen, T.; Anderson, S.; Andrieu, B.; Arnoud, Y.; Askew, A.; /Buenos Aires U. /Rio de Janeiro, CBPF /Rio de Janeiro State U. /Sao

    2004-12-01

    The authors present a measurement of the cross section for Z production times the branching fraction to {tau} leptons, {sigma} {center_dot} Br(Z {yields} {tau}{sup +}{tau}{sup -}), in p{bar p} collisions at {radical}s = 1.96 TeV in the channel in which one {tau} decays into {mu}{nu}{sub {mu}}{nu}{sub {tau}}, and the other into hadrons + {nu}{sub {tau}} or e{nu}{sub e}{nu}{sub {tau}}. The data sample corresponds to an integrated luminosity of 226 pb{sup -1} collected with the D0 detector at the Fermilab Tevatron collider. The final sample contains 2008 candidate events with an estimated background of 55%. From this they obtain {sigma} {center_dot} Br(Z {yields} {tau}{sup +}{tau}{sup -}) = 237 {+-} 15(stat) {+-} 18(sys) {+-} 15(lum) pb, in agreement with the standard model prediction.

  2. Search for pair production of scalar top quarks decaying to a tau lepton and a b quark in 1.96 TeV ppbar collisions

    SciTech Connect

    Khotilovich, Vadim, G.; /Texas A-M

    2008-05-01

    I present the results of a search for pair production of scalar top quarks ({tilde t}{sub 1}) in an R-parity violating supersymmetric scenario using 322 pb{sup -1} of p{bar p} collisions at {radical}s = 1.96 TeV collected by the upgraded Collider Detector at Fermilab. I assume each {tilde t}{sub 1} decays into a {tau} lepton and a b quark, with branching ratio {beta}, and search for final states containing either an electron or a muon from a leptonic {tau} decay, a hadronically decaying {tau} lepton, and two or more jets. Two candidate events pass my final selection criteria, consistent with the expectation from standard model processes. I present upper limits on the cross section times branching ratio squared {sigma}({tilde t}{sub 1}{bar {tilde t}}{sub 1}) x {beta}{sup 2} as a function of the stop mass m({tilde t}{sub 1}). Assuming {beta} = 1, I set a 95% confidence level limit m({tilde t}{sub 1}) > 153 GeV=c{sup 2}. These limits are also fully applicable to the case of a pair produced third generation scalar leptoquark that decays into a {tau} lepton and a b quark.

  3. Correlation between flavor-violating decay of long-lived slepton and tau in the coannihilation scenario with the seesaw mechanism

    SciTech Connect

    Kaneko, Satoru [Juntendo University, Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421 (Japan); Saito, Hiroki; Sato, Joe [Department of Physics, Saitama University, Shimo-Okubo, Sakura-ku, Saitama, 338-8570 (Japan); Shimomura, Takashi [Yukawa Institute for Theoretical Physics, Kyoto University, Kyoto 606-8502 (Japan); Vives, Oscar [Departament de Fisica Teorica and IFIC, Universitat de Valencia--CSIC, E46100, Burjassot, Valencia (Spain); Yamanaka, Masato [Maskawa Institute, Kyoto Sangyo University, Kyoto 603-8555 (Japan)

    2011-06-01

    We investigate flavor violating decays of the long-lived lightest slepton and the tau lepton in the coannihilation region of the minimal supersymmetric standard model with a seesaw mechanism to generate neutrino masses. We consider a situation where the mass difference between the lightest neutralino, as the lightest supersymmetric particle, and the lightest slepton, as the next-to-lightest supersymmetric particle, is smaller than the mass of tau lepton. In this situation, the lifetime of the lightest slepton is very long and it is determined by lepton flavor violating (LFV) couplings because the slepton mainly consists of the lighter stau and the flavor conserving 2-body decay is kinematically forbidden. We show that the lifetime can change many orders of magnitude by varying the Yukawa couplings entering the seesaw mechanism. We also show that the branching ratios of LFV tau decays are strongly correlated with the lightest slepton lifetime. Therefore the branching ratios of LFV tau decays can be determined or constrained by measuring the slepton lifetime at the LHC experiment.

  4. Improved Limits on Lepton-Flavor-Violating tau Decays to l phi , l rho , lK^{*}, and lK[over -bar]^{*}

    E-print Network

    Fisher, Peter H.

    We search for the neutrinoless, lepton-flavor-violating tau decays ?[over-bar]??[over-bar]V[superscript 0], where ? is an electron or muon and V[superscript 0] is a vector meson reconstructed as ??K[superscript +]K[superscript ...

  5. Phosphorylation of tau protein in tau-transfected 3T3 cells.

    PubMed

    Sygowski, L A; Fieles, A W; Lo, M M; Scott, C W; Caputo, C B

    1993-11-01

    The tau protein of Alzheimer paired helical filaments (PHFs) is aberrantly phosphorylated, as evidenced by its reactivity with several phosphate-dependent antibodies. We sought to identify whether this unusual phosphorylation state exists in tau expressed by transfected NIH 3T3 fibroblasts. Immunoblot analysis of cell clones transfected with constructs for either the 3-repeat or 4-repeat isoforms of tau revealed two tau bands, with the lower band migrating with unmodified tau in each case. Antibodies T3P and tau-1 were used to probe these bands, as they also react with PHF-tau in a phosphate-dependent manner. The epitopes for both antibodies were phosphorylated in both tau isoforms. Only the upper band was phosphorylated at the T3P site whereas phosphorylation at the tau-1 site was not always associated with a shift of tau mobility on gels. Tau in both bands was soluble, in contrast to PHF-tau, and was competent to bind to exogenously added bovine microtubules. Colchicine treatment of the cells resulted in an inhibition of phosphorylation at both sites, through an unknown mechanism. In conclusion human tau expressed in 3T3 cells was phosphorylated at the T3P and tau-1 sites as is PHF-tau, although no PHFs formed and the phosphorylated tau was competent to bind to microtubules. PMID:8302160

  6. {tau} weak magnetic dipole moment

    SciTech Connect

    Gonzalez-Sprinberg, Gabriel [Facultad de Ciencias, Universidad de la Rep'ublica Montevideo (Uruguay)

    1998-10-05

    The weak magnetic dipole moment of the {tau}-lepton is reviewed. Standard Model predictions and the last experimental results are presented. These may result in a stringent test for both their point-like structure and also for new physics.

  7. The dipion mass spectrum in e+e- annihilation and tau decay: Isospin symmetry breaking effects from the (rho, omega, phi) mixing

    SciTech Connect

    Benayoun, M.; David, P.; Del Buono, L.; /Paris U., VI-VII; Leitner, O.; /Paris U., VI-VII /Frascati; O'Connell, H.B.; /Fermilab

    2008-01-01

    A way to explain the puzzling difference between the pion form factor as measured in e{sup +}e{sup -} annihilations and in {tau} decays is discussed. We show that isospin symmetry breaking, beside the already identified effects, produces also a full mixing between the {rho}{sup 0}, {omega} and {phi} mesons which generates an isospin 0 component inside the {rho}{sup 0} meson. This effect, not accounted for in current treatments of the problem, seems able to account for the apparent mismatch between e{sup +}e{sup -} and {tau} data below the {phi} mass.

  8. Tau protein pathology in neurodegenerative diseases

    Microsoft Academic Search

    Maria Grazia Spillantini; Michel Goedert

    1998-01-01

    Abundant tau-positive neurofibrillary lesions constitute a defining neuropathological characteristic of Alzheimer's disease. Filamentous tau pathology is also central to a number of other dementing disorders, such as Pick's disease, progressive supranuclear palsy, corticobasal degeneration and familial frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17). The discovery of mutations in the tau gene in FTDP-17 has firmly established the relevance

  9. Prospect for measuring the CP phase in the h-tau-tau coupling at the LHC

    DOE PAGESBeta

    Askew, Andrew; Jaiswal, Prerit; Okui, Takemichi; Prosper, Harrison B.; Sato, Nobuo

    2015-04-01

    The search for a new source of CP violation is one of the most important endeavors in particle physics. A particularly interesting way to perform this search is to probe the CP phase in the $h\\tau\\tau$ coupling, as the phase is currently completely unconstrained by all existing data. Recently, a novel variable $\\Theta$ was proposed for measuring the CP phase in the $h\\tau\\tau$ coupling through the $\\tau^\\pm \\to \\pi^\\pm \\pi^0 \

  10. Search for a low-mass scalar Higgs boson decaying to a tau pair in single-photon decays of ?(1S)

    NASA Astrophysics Data System (ADS)

    Lees, J. P.; Poireau, V.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Palano, A.; Eigen, G.; Stugu, B.; Brown, D. N.; Georges, A.; Kerth, L. T.; Kolomensky, Yu. G.; Lynch, G.; Paudel, U.; Koch, H.; Schroeder, T.; Asgeirsson, D. J.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; So, R. Y.; Khan, A.; Blinov, V. E.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Yushkov, A. N.; Bondioli, M.; Kirkby, D.; Lankford, A. J.; Mandelkern, M.; Atmacan, H.; Gary, J. W.; Liu, F.; Long, O.; Vitug, G. M.; Campagnari, C.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.; West, C. A.; Eisner, A. M.; Kroseberg, J.; Lockman, W. S.; Martinez, A. J.; Schumm, B. A.; Seiden, A.; Chao, D. S.; Cheng, C. H.; Echenard, B.; Flood, K. T.; Hitlin, D. G.; Ongmongkolkul, P.; Porter, F. C.; Rakitin, A. Y.; Andreassen, R.; Huard, Z.; Meadows, B. T.; Sokoloff, M. D.; Sun, L.; Bloom, P. C.; Ford, W. T.; Gaz, A.; Nauenberg, U.; Smith, J. G.; Wagner, S. R.; Ayad, R.; Toki, W. H.; Spaan, B.; Schubert, K. R.; Schwierz, R.; Bernard, D.; Verderi, M.; Clark, P. J.; Playfer, S.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Fioravanti, E.; Garzia, I.; Luppi, E.; Munerato, M.; Piemontese, L.; Santoro, V.; Baldini-Ferroli, R.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.; Contri, R.; Guido, E.; Lo Vetere, M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Bhuyan, B.; Prasad, V.; Lee, C. L.; Morii, M.; Edwards, A. J.; Adametz, A.; Uwer, U.; Lacker, H. M.; Lueck, T.; Dauncey, P. D.; Mallik, U.; Chen, C.; Cochran, J.; Meyer, W. T.; Prell, S.; Rubin, A. E.; Gritsan, A. V.; Guo, Z. J.; Arnaud, N.; Davier, M.; Derkach, D.; Grosdidier, G.; Le Diberder, F.; Lutz, A. M.; Malaescu, B.; Roudeau, P.; Schune, M. H.; Stocchi, A.; Wormser, G.; Lange, D. J.; Wright, D. M.; Chavez, C. A.; Coleman, J. P.; Fry, J. R.; Gabathuler, E.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; Di Lodovico, F.; Sacco, R.; Sigamani, M.; Cowan, G.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Fritsch, M.; Gradl, W.; Griessinger, K.; Hafner, A.; Prencipe, E.; Barlow, R. J.; Jackson, G.; Lafferty, G. D.; Behn, E.; Cenci, R.; Hamilton, B.; Jawahery, A.; Roberts, D. A.; Dallapiccola, C.; Cowan, R.; Dujmic, D.; Sciolla, G.; Cheaib, R.; Lindemann, D.; Patel, P. M.; Robertson, S. H.; Biassoni, P.; Neri, N.; Palombo, F.; Stracka, S.; Cremaldi, L.; Godang, R.; Kroeger, R.; Sonnek, P.; Summers, D. J.; Nguyen, X.; Simard, M.; Taras, P.; De Nardo, G.; Monorchio, D.; Onorato, G.; Sciacca, C.; Martinelli, M.; Raven, G.; Jessop, C. P.; LoSecco, J. M.; Wang, W. F.; Honscheid, K.; Kass, R.; Brau, J.; Frey, R.; Sinev, N. B.; Strom, D.; Torrence, E.; Feltresi, E.; Gagliardi, N.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simi, G.; Simonetto, F.; Stroili, R.; Akar, S.; Ben-Haim, E.; Bomben, M.; Bonneaud, G. R.; Briand, H.; Calderini, G.; Chauveau, J.; Hamon, O.; Leruste, Ph.; Marchiori, G.; Ocariz, J.; Sitt, S.; Biasini, M.; Manoni, E.; Pacetti, S.; Rossi, A.; Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Casarosa, G.; Cervelli, A.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Perez, A.; Rizzo, G.; Walsh, J. J.; Lopes Pegna, D.; Olsen, J.; Smith, A. J. S.; Telnov, A. V.; Anulli, F.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Li Gioi, L.; Mazzoni, M. A.; Piredda, G.; Bünger, C.; Grünberg, O.; Hartmann, T.; Leddig, T.; Voß, C.; Waldi, R.; Adye, T.; Olaiya, E. O.; Wilson, F. F.; Emery, S.; Hamel de Monchenault, G.; Vasseur, G.; Yèche, Ch.; Aston, D.; Bard, D. J.; Bartoldus, R.; Benitez, J. F.; Cartaro, C.; Convery, M. R.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Ebert, M.; Field, R. C.; Franco Sevilla, M.; Fulsom, B. G.; Gabareen, A. M.; Graham, M. T.; Grenier, P.; Hast, C.; Innes, W. R.; Kelsey, M. H.; Kim, P.; Kocian, M. L.; Leith, D. W. G. S.; Lewis, P.; Lindquist, B.; Luitz, S.; Luth, V.; Lynch, H. L.; MacFarlane, D. B.; Muller, D. R.; Neal, H.; Nelson, S.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Snyder, A.; Su, D.; Sullivan, M. K.; Va'vra, J.; Wagner, A. P.; Wisniewski, W. J.; Wittgen, M.; Wright, D. H.; Wulsin, H. W.; Young, C. C.; Ziegler, V.; Park, W.; Purohit, M. V.; White, R. M.; Wilson, J. R.; Randle-Conde, A.; Sekula, S. J.; Bellis, M.; Burchat, P. R.; Miyashita, T. S.; Puccio, E. M. T.; Alam, M. S.; Ernst, J. A.; Gorodeisky, R.; Guttman, N.; Peimer, D. R.; Soffer, A.; Lund, P.; Spanier, S. M.; Ritchie, J. L.; Ruland, A. M.; Schwitters, R. F.; Wray, B. C.; Izen, J. M.; Lou, X. C.; Bianchi, F.; Gamba, D.; Zambito, S.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Oyanguren, A.

    2013-10-01

    We search for a low-mass scalar CP-odd Higgs boson, A0, produced in the radiative decay of the upsilon resonance and decaying into a ?+?- pair: ?(1S)??A0. The production of ?(1S) mesons is tagged by ?(2S)??+?-?(1S) transitions, using a sample of (98.3±0.9)×106 ?(2S) mesons collected by the BABAR detector. We find no evidence for a Higgs boson in the mass range 3.5?mA0?9.2GeV, and combine these results with our previous search for the tau decays of the light Higgs in radiative ?(3S) decays, setting limits on the coupling of A0 to the bb¯ quarks in the range 0.09-1.9. Our measurements improve the constraints on the parameters of the next-to-minimal-supersymmetric Standard Model and similar theories with low-mass scalar degrees of freedom.

  11. Estimate of the spectral classes of the T Tau type stars HL Tau and DG Tau

    Microsoft Academic Search

    R. V. Yudin; A. S. Miroshnichenko

    1988-01-01

    Estimates have been made of the fundamental physical characteristics of two stars in the stage of evolution to the main sequence. The revised spectral classification for the star HL Tau has made it possible to achieve agreement with the published physical characteristics. The results of the estimates by two independent methods of the fundamental physical characteristics of the two stars

  12. Measurements of the tau mass and the mass difference of the tau+ and tau- at BABAR

    E-print Network

    Fisher, Peter H.

    We present the result from a precision measurement of the mass of the tau lepton, M?, based on 423??fb[subscript -1] of data recorded at the ?(4S) resonance with the BABAR detector. Using a pseudomass endpoint method, we ...

  13. The acetylation of tau inhibits its function and promotes pathological tau aggregation

    PubMed Central

    Cohen, Todd J.; Guo, Jing L.; Hurtado, David E.; Kwong, Linda K.; Mills, Ian P.; Trojanowski, John Q.; Lee, Virginia M. Y.

    2011-01-01

    The microtubule associated protein tau promotes neuronal survival through binding and stabilization of MTs. Phosphorylation regulates tau–microtubule interactions and hyperphosphorylation contributes to the aberrant formation of insoluble tau aggregates in Alzheimer’s disease (AD) and related tauopathies1. However, other pathogenic post-translational tau modifications have not been well characterized. Here we demonstrate that tau acetylation inhibits tau function via impaired tau–microtubule interactions and promotes pathological tau aggregation. Mass spectrometry analysis identified specific lysine residues, including lysine 280 (K280) within the microtubule-binding motif as the major sites of tau acetylation. Immunohistochemical and biochemical studies of brains from tau transgenic mice and patients with AD and related tauopathies showed that acetylated tau pathology is specifically associated with insoluble, Thioflavin-positive tau aggregates. Thus, tau K280 acetylation in our studies was only detected in diseased tissue, suggesting it may have a role in pathological tau transformation. This study suggests that tau K280 acetylation is a potential target for drug discovery and biomarker development for AD and related tauopathies. PMID:21427723

  14. Events with large missing transverse energy at the cern collider: I.W-->taunu decay and test of tau-mu-e universality at Q2=mw2

    Microsoft Academic Search

    C. Albajar; M. G. Albrow; O. C. Allkofer; G. Arnison; A. Astbury; B. Aubert; T. Axon; C. Bacci; T. Bacon; N. Bains; J. R. Batley; G. Bauer; S. Beingessner; J. Bellinger; A. Bettini; A. Bezaguet; K. Bos; E. Buckley; G. Bunce; G. Busetto; P. Catz; P. Cennini; S. Centro; F. Ceradini; D. G. Charlton; G. Ciapetti; S. Cittolin; D. Clarke; D. Cline; C. Cochet; J. Colas; P. Colas; M. Corden; J. A. Coughlan; G. Cox; D. Dau; M. Debeer; J. P. Debrion; M. Degiorgi; M. della Negra; M. Demoulin; B. Denby; D. Denegri; A. Diciaccio; L. Dobrzynski; J. Dorenbosch; J. D. Dowell; E. Duchovni; R. Edgecock; K. Eggert; E. Eisenhandler; N. Ellis; P. Erhard; H. Faissner; I. F. Fensome; M. Pincke-Keeler; P. Flynn; G. Fontaine; R. Frey; R. Fruhwirth; L. Gately; J. Garvey; D. Gee; S. Geer; A. Geisser; C. Ghesquiere; P. Ghez; F. Ghio; P. Giacomelli; W. R. Gibson; Y. Giraud-Heraud; A. Givernaud; A. Gonidec; H. Grassmann; G. Grayer; W. Haynes; S. J. Haywood; H. Hoffmann; D. J. Holthuizen; R. J. Homer; A. Honma; M. Ikeda; W. Jank; M. Jimack; G. Jorat; P. I. P. Kalmus; V. Karimäki; R. Keeler; I. Kenyon; A. Kernan; A. Khan; W. Kienzle; R. Kinnunen; M. Krammer; J. Kroll; D. Kryn; P. Kyberd; F. Lacava; J. P. Laugier; J. P. Lees; R. Leuchs; S. Levegrun; M. Levi; S. Li; D. Linglin; E. Locci; K. Long; T. Markiewicz; C. Markou; M. Markytan; G. Maurin; J.-P. Mendiburu; A. Meneguzzo; J. P. Merlo; T. Meyer; M.-N. Minard; M. Mohammadi; K. Morgan; M. Moricca; H.-G. Moser; B. Mours; Th. Muller; A. Nandi; L. Naumann; P. Nedelec; A. Norton; D. Pascoli; F. Pauss; C. Perault; P. Petta; E. Petrolo; G. Piano Mortari; E. Pietarinen; C. Pigot; M. Pimiä; D. Pitman; A. Placci; J.-P. Porte; E. Radermacher; T. Redelberger; H. Reithler; J.-P. Revol; J. Richman; D. Robinson; J. Rohlf; P. Rossi; C. Rubbia; W. Ruhm; G. Sajot; G. Salvini; J. Sass; D. Samyn; A. Savoy-Navarro; D. Schinzel; A. Schwartz; W. Scott; C. Seez; T. P. Shah; I. Sheer; I. Siotis; D. Smith; R. Sobie; P. Sphicas; J. Strauss; J. Streets; C. Stubenrauch; D. Summers; K. Sumorok; F. Szoncso; C. Tao; A. Taurok; I. Ten Have; S. Tether; G. Thompson; E. Tscheslog; J. Tuominiemi; B. van Eijk; J. P. Vialle; L. Villasenor; T. S. Virdee; H. von der Schmitt; W. von Schlippe; J. Vrana; V. Vuillemin; K. Wacker; H. D. Wahl; P. Watkins; A. Wildish; J. Wilson; I. Wingerter; S. J. Wimpenny; X. Wu; C.-E. Wulz; T. Wyatt; M. Yvert; C. Zaccardelli; I. Zacharov; N. Zaganidis; L. Zanello; P. Zotto

    1987-01-01

    We report results based on a sample of events with large missing transverse energy corresponding to 715 nb-n of data from the UA1 experiment at the CERN proton-antiproton collider. High transverse-momentum tau-leptons from W decays are observed for the first time through their semi-hadronic decay modes and associated missing transverse energy. The measured relative rates of W-->enu, W-->munu, and W-->taunu

  15. TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation

    PubMed Central

    Liao, Jung-Chi; Yang, T. Tony; Weng, Rueyhung Roc; Kuo, Ching-Te; Chang, Chih-Wei

    2015-01-01

    Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes. Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and cellular processes involved. TTBK2 possesses a casein kinase 1 (CK1) kinase domain followed by a ~900 amino acid segment, potentially responsible for its localization and substrate recruitment. It is known to bind to CEP164, a centriolar protein, and EB1, a microtubule plus-end tracking protein. In addition to autophosphorylation, known phosphorylation substrates of TTBK2 include tau, tubulin, CEP164, CEP97, and TDP-43, a neurodegeneration-associated protein. Mutations of TTBK2 are associated with spinocerebellar ataxia type 11. In addition, TTBK2 is essential for regulating the growth of axonemal microtubules in ciliogenesis. It also plays roles in resistance of cancer target therapies and in regulating glucose and GABA transport. Reported sites of TTBK2 localization include the centriole/basal body, the midbody, and possibly the mitotic spindles. Together, TTBK2 is a multifunctional kinase involved in important cellular processes and demands augmented efforts in investigating its functions. PMID:25950000

  16. Measurement of the Tau- to F1(1285) Pi- Nu/Tau Branching Fraction And a Search for Second-Class Currents in Tau to Eta-Prime(958) Pi- Nu/Tau

    SciTech Connect

    Alwyn, K.E.; /Manchester U.

    2011-12-01

    The {tau}{sup -} {yields} {eta}{pi}{sup -}{pi}+{pi}{sup -}{nu}{tau} decay with the {eta} {yields} {gamma}{gamma} mode is studied using 384 fb{sup -1} of data collected by the BaBar detector. The branching fraction is measured to be (1.60 {+-} 0.05 {+-} 0.11) x 10{sup -4}. It is found that {tau}{sup -} {yields} f1(1285){pi}{sup -}{nu}{tau} {yields} {eta}{pi}{sup -}{pi}+{pi}{sup -}{nu}{tau} is the dominant decay mode with a branching fraction of (1.11 {+-} 0.06 {+-} 0.05) x 10{sup -4}. The first error is statistical and the second systematic. In addition, a 90% confidence level upper limit on the branching fraction of the {tau}{sup -} {yields} {eta}{prime}(958){pi}{sup -}{nu}{tau} decay is measured to be 7.2 x 10{sup -6}. This last decay proceeds through a second-class current and is expected to be forbidden in the limit of isospin symmetry.

  17. Branching fractions of tau leptons to three charged hadrons

    E-print Network

    Besson, David Zeke; Zhao, X.

    2003-05-01

    From electron-positron collision data collected with the CLEO detector operating at Cornell Electron Storage Ring near roots=10.6 GeV, improved measurements of the branching fractions for tau decays into three explicitly ...

  18. GG Tau: The Ringworld Revisited

    NASA Astrophysics Data System (ADS)

    Guilloteau, Stéphane; Dutrey, Anne

    GG Tau is a textbook example of a binary system. The circumstellar material around GG Tau is divided in several distinct regions: 1) small, low mass, circumstellar disks, detected in the near-IR and mm domain, 2) a well defined ring, of inner radius 180 AU, detected in the mm domain and in scattered near-IR light, 3) a more extended, colder disk detected in the 13CO(2-1) and 13CO(1-0) lines. Recent observations of the 12CO(2-1) clearly show this extended disk, but also reveal a fourth component of the circumstellar material: (relatively) diffuse and hot gas in the tidally unstable region. Estimate of the gas content suggest this material may be feeding the inner disks at about 10-6 msun/yr.

  19. HL Tau - The Missing Dust

    Microsoft Academic Search

    T. Rettig; S. Brittain; T. Simon; C. Kulesa; J. Haywood

    2004-01-01

    High-resolution infrared spectra of HL Tau exhibit broad emission lines of 12CO gas phase molecules as well as narrow absorption lines of 12CO, 13CO, and C18O. The broad emission lines of vibrationally-excited 12CO are dominated by the hot (T ~1500 K) inner-disk (radius r < 0.2 AU). The narrow absorption lines of CO are found to originate from the circumstellar

  20. Precision Measurement of the Mass of the $\\tau$ Lepton

    E-print Network

    Ablikim, M; Ai, X C; Albayrak, O; Albrecht, M; Ambrose, D J; An, F F; An, Q; Bai, J Z; Ferroli, R Baldini; Ban, Y; Bennett, J V; Bertani, M; Bian, J M; Boger, E; Bondarenko, O; Boyko, I; Braun, S; Briere, R A; Cai, H; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, J C; Chen, M L; Chen, S J; Chen, X; Chen, X R; Chen, Y B; Cheng, H P; Chu, X K; Chu, Y P; Cronin-Hennessy, D; Dai, H L; Dai, J P; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; Ding, W M; Ding, Y; Dong, C; Dong, J; Dong, L Y; Dong, M Y; Du, S X; Fan, J Z; Fang, J; Fang, S S; Fang, Y; Fava, L; Feng, C Q; Fu, C D; Fuks, O; Gao, Q; Gao, Y; Geng, C; Goetzen, K; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, T; Guo, Y P; Han, Y L; Harris, F A; He, K L; He, M; He, Z Y; Held, T; Heng, Y K; Hou, Z L; Hu, C; Hu, H M; Hu, J F; Hu, T; Huang, G M; Huang, G S; Huang, H P; Huang, J S; Huang, L; Huang, X T; Huang, Y; Hussain, T; Ji, C S; Ji, Q; Ji, Q P; Ji, X B; Ji, X L; Jiang, L L; Jiang, L W; Jiang, X S; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Johansson, T; Kalantar-Nayestanaki, N; Kang, X L; Kang, X S; Kavatsyuk, M; Kloss, B; Kopf, B; Kornicer, M; Kuehn, W; Kupsc, A; Lai, W; Lange, J S; Lara, M; Larin, P; Leyhe, M; Li, C H; Li, Cheng; Li, Cui; Li, D; Li, D M; Li, F; Li, G; Li, H B; Li, J C; Li, K; Li, Lei; Li, P R; Li, Q J; Li, T; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Lin, D X; Liu, B J; Liu, C L; Liu, C X; Liu, F H; Liu, Fang; Liu, Feng; Liu, H B; Liu, H H; Liu, H M; Liu, J; Liu, J P; Liu, K; Liu, K Y; Liu, P L; Liu, Q; Liu, S B; Liu, X; Liu, Y B; Liu, Z A; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H; Lou, X C; Lu, G R; Lu, H J; Lu, H L; Lu, J G; Lu, X R; Lu, Y; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lv, M; Ma, F C; Ma, H L; Ma, Q M; Ma, S; Ma, T; Ma, X Y; Maas, F E; Maggiora, M; Malik, Q A; Mao, Y J; Mao, Z P; Messchendorp, J G; Min, J; Min, T J; Mitchell, R E; Mo, X H; Mo, Y J; Moeini, H; Morales, C Morales; Moriya, K; Muchnoi, N Yu; Muramatsu, H; Nefedov, Y; Nikolaev, I B; Ning, Z; Nisar, S; Niu, X Y; Olsen, S L; Ouyang, Q; Pacetti, S; Pelizaeus, M; Peng, H P; Peters, K; Ping, J L; Ping, R G; Poling, R; Q., N; Qi, M; Qian, S; Qiao, C F; Qin, L Q; Qin, X S; Qin, Y; Qin, Z H; Qiu, J F; Rashid, K H; Redmer, C F; Ripka, M; Rong, G; Ruan, X D; Sarantsev, A; Schoenning, K; Schumann, S; Shan, W; Shao, M; Shen, C P; Shen, X Y; Sheng, H Y; Shepherd, M R; Song, W M; Song, X Y; Spataro, S; Spruck, B; Sun, G X; Sun, J F; Sun, S S; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Tapan, I; Thorndike, E H; Toth, D; Ullrich, M; Uman, I; Varner, G S; Wang, B; Wang, D; Wang, D Y; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, Q J; Wang, S G; Wang, W; Wang, X F; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z H; Wang, Z Y; Wei, D H; Wei, J B; Weidenkaff, P; Wen, S P; Werner, M; Wiedner, U; Wolke, M; Wu, L H; Wu, N; Wu, Z; Xia, L G; Xia, Y; Xiao, D; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, L; Xu, Q J; Xu, Q N; Xu, X P; Xue, Z; Yan, L; Yan, W B; Yan, W C; Yan, Y H; Yang, H X; Yang, L; Yang, Y; Yang, Y X; Ye, H; Ye, M; Ye, M H; Yu, B X; Yu, C X; Yu, H W; Yu, J S; Yu, S P; Yuan, C Z; Yuan, W L; Yuan, Y; Zafar, A A; Zallo, A; Zang, S L; Zeng, Y; Zhang, B X; Zhang, B Y; Zhang, C; Zhang, C B; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J J; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, S H; Zhang, X J; Zhang, X Y; Zhang, Y; Zhang, Y H; Zhang, Z H; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, J W; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, Q W; Zhao, S J; Zhao, T C; Zhao, X H; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, Y H; Zhong, B; Zhou, L; Zhou, Li; Zhou, X; Zhou, X K; Zhou, X R; Zhou, X Y; Zhu, K; Zhu, K J; Zhu, X L; Zhu, Y C; Zhu, Y S; Zhu, Z A; Zhuang, J; Zou, B S; Zou, J H

    2014-01-01

    An energy scan near the $\\tau$ pair production threshold has been performed using the BESIII detector. About $24$ pb$^{-1}$ of data, distributed over four scan points, was collected. This analysis is based on $\\tau$ pair decays to $ee$, $e\\mu$, $eh$, $\\mu\\mu$, $\\mu h$, $hh$, $e\\rho$, $\\mu\\rho$ and $\\pi\\rho$ final states, where $h$ denotes a charged $\\pi$ or $K$. The mass of the $\\tau$ lepton is measured from a maximum likelihood fit to the $\\tau$ pair production cross section data to be $m_{\\tau} = (1776.91\\pm0.12 ^{+0.10}_{-0.13}$) MeV/$c^2$, which is currently the most precise value in a single measurement.

  1. Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP

    PubMed Central

    Watts, Kelly; Grossman, Murray; Glass, Jonathan; Lah, James J.; Hales, Chadwick; Shelnutt, Matthew; Van Deerlin, Vivianna; Trojanowski, John Q.; Levey, Allan I.

    2013-01-01

    Objectives: To validate the ability of candidate CSF biomarkers to distinguish between the 2 main forms of frontotemporal lobar degeneration (FTLD), FTLD with TAR DNA-binding protein 43 (TDP-43) inclusions (FTLD-TDP) and FTLD with Tau inclusions (FTLD-Tau). Methods: Antemortem CSF samples were collected from 30 patients with FTLD in a single-center validation cohort, and CSF levels of 5 putative FTLD-TDP biomarkers as well as levels of total Tau (t-Tau) and Tau phosphorylated at threonine 181 (p-Tau181) were measured using independent assays. Biomarkers most associated with FTLD-TDP were then tested in a separate 2-center validation cohort composed of subjects with FTLD-TDP, FTLD-Tau, Alzheimer disease (AD), and cognitively normal subjects. The sensitivity and specificity of FTLD-TDP biomarkers were determined. Results: In the first validation cohort, FTLD-TDP cases had decreased levels of p-Tau181 and interleukin-23, and increased Fas. Reduced ratio of p-Tau181 to t-Tau (p/t-Tau) was the strongest predictor of FTLD-TDP pathology. Analysis in the second validation cohort showed CSF p/t-Tau ratio <0.37 to distinguish FTLD-TDP from FTLD-Tau, AD, and healthy seniors with 82% sensitivity and 82% specificity. Conclusion: A reduced CSF p/t-Tau ratio represents a reproducible, validated biomarker for FTLD-TDP with performance approaching well-established CSF AD biomarkers. Introducing this biomarker into research and the clinical arena can significantly increase the power of clinical trials targeting abnormal accumulations of TDP-43 or Tau, and select the appropriate patients for target-specific therapies. Classification of evidence: This study provides Class II evidence that the CSF p/t-Tau ratio distinguishes FTLD-TDP from FTLD-Tau. PMID:24174584

  2. Search for neutral Higgs bosons decaying to tau pairs produced in association with b quarks in pp? collisions at ?s=1.96 TeV

    DOE PAGESBeta

    Abazov, Victor Mukhamedovich; Abbott, Braden Keim; Acharya, Bannanje Sripath; Adams, Mark Raymond; Adams, Todd; Alexeev, Guennadi D; Alkhazov, Georgiy D; Alton, Andrew K; Alverson, George O; Alves, Gilvan Augusto; et al

    2011-09-12

    We report results from a search for neutral Higgs bosons produced in association with b quarks using data recorded by the D0 experiment at the Fermilab Tevatron Collider and corresponding to an integrated luminosity of 7.3 fb-1. This production mode can be enhanced in several extensions of the standard model (SM) such as in its minimal supersymmetric extension (MSSM) at high tanß. We search for Higgs bosons decaying to tau pairs with one tau decaying to a muon and neutrinos and the other to hadrons. The data are found to be consistent with SM expectations, and we set upper limitsmore »on the cross section times branching ratio in the Higgs boson mass range from 90 to 320 GeV/c2. We interpret our result in the MSSM parameter space, excluding tanß values down to 25 for Higgs boson masses below 170 GeV/c2.« less

  3. Search for neutral Higgs bosons decaying to tau pairs produced in association with b quarks in pp? collisions at ?s=1.96 TeV

    DOE PAGESBeta

    Abazov, Victor Mukhamedovich [Dubna, JINR; Abbott, Braden Keim [Oklahoma U.; Acharya, Bannanje Sripath [Tata Inst.; Adams, Mark Raymond [Illinois U., Chicago; Adams, Todd [Florida State U.; Alexeev, Guennadi D [Dubna, JINR; Alkhazov, Georgiy D [St. Petersburg, INP; Alton, Andrew K [Michigan U.; Augustana Coll., Sioux Falls; Alverson, George O [Northeastern U.; Alves, Gilvan Augusto [Rio de Janeiro, CBPF; Aoki, Masato [Fermilab; Louisiana Tech. U.

    2011-09-12

    We report results from a search for neutral Higgs bosons produced in association with b quarks using data recorded by the D0 experiment at the Fermilab Tevatron Collider and corresponding to an integrated luminosity of 7.3 fb-1. This production mode can be enhanced in several extensions of the standard model (SM) such as in its minimal supersymmetric extension (MSSM) at high tanß. We search for Higgs bosons decaying to tau pairs with one tau decaying to a muon and neutrinos and the other to hadrons. The data are found to be consistent with SM expectations, and we set upper limits on the cross section times branching ratio in the Higgs boson mass range from 90 to 320 GeV/c2. We interpret our result in the MSSM parameter space, excluding tanß values down to 25 for Higgs boson masses below 170 GeV/c2.

  4. Search for neutral Higgs bosons decaying to tau pairs produced in association with b quarks in pp? collisions at ?s=1.96 TeV

    SciTech Connect

    Abazov, Victor Mukhamedovich [Dubna, JINR; Abbott, Braden Keim [Oklahoma U.; Acharya, Bannanje Sripath [Tata Inst.; Adams, Mark Raymond [Illinois U., Chicago; Adams, Todd [Florida State U.; Alexeev, Guennadi D [Dubna, JINR; Alkhazov, Georgiy D [St. Petersburg, INP; Alton, Andrew K [Michigan U.; Augustana Coll., Sioux Falls; Alverson, George O [Northeastern U.; Alves, Gilvan Augusto [Rio de Janeiro, CBPF; Aoki, Masato [Fermilab; Louisiana Tech. U.

    2011-09-12

    We report results from a search for neutral Higgs bosons produced in association with b quarks using data recorded by the D0 experiment at the Fermilab Tevatron Collider and corresponding to an integrated luminosity of 7.3 fb-1. This production mode can be enhanced in several extensions of the standard model (SM) such as in its minimal supersymmetric extension (MSSM) at high tanß. We search for Higgs bosons decaying to tau pairs with one tau decaying to a muon and neutrinos and the other to hadrons. The data are found to be consistent with SM expectations, and we set upper limits on the cross section times branching ratio in the Higgs boson mass range from 90 to 320 GeV/c2. We interpret our result in the MSSM parameter space, excluding tanß values down to 25 for Higgs boson masses below 170 GeV/c2.

  5. Tau as a biomarker of neurodegenerative diseases

    PubMed Central

    Schraen-Maschke, Susanna; Sergeant, Nicolas; Dhaenens, Claire-Marie; Bombois, Stephanie; Deramecourt, Vincent; Caillet-Boudin, Marie-Laure; Pasquier, Florence; Maurage, Claude-Alain; Sablonniere, Bernard; Vanmechelen, Eugeen; Buee, Luc

    2008-01-01

    Summary The microtubule associated protein Tau is mainly expressed in neurons of the central nervous system and is crucial in axonal maintenance and axonal transport. The rationale for Tau as a biomarker of neurodegenerative diseases is that it is a major component of abnormal intraneuronal aggregates observed in numerous of these diseases named Tauopathies, including Alzheimer’s disease. The molecular diversity of Tau is very useful when analysing it in the brain or in the peripheral fluids. Immunohistochemical and biochemical characterisation of Tau aggregates in the brain allows the post-mortem classification and differential diagnosis of Tauopathies. As peripheral biomarker of Alzheimer’s disease in the cerebrospinal fluid, Tau proteins are now validated for diagnosis and predictive purposes. For the future, the detailed characterization of Tau in brain and in peripheral fluids will lead to novel promising biomarkers for differential diagnosis of dementia and monitoring of therapeutics. PMID:20477391

  6. The lepton flavor violating decay {tau}{sup {+-}} {yields} Micro-Sign {sup {+-}} Micro-Sign {sup {+-}} Micro-Sign {sup Minus-Or-Plus-Sign} at LHCb

    SciTech Connect

    Keune, A., E-mail: anne.keune@epfl.ch [Ecole Polytechnique Federale de Lausanne, Laboratoire de Physique des Hautes Energies (Switzerland)

    2012-09-15

    The possibility of improving the limit on the branching fraction of the lepton flavor violating decay {tau}{sup {+-}} {yields} Micro-Sign {sup {+-}} Micro-Sign {sup {+-}} Micro-Sign {sup Minus-Or-Plus-Sign} at LHCb is discussed. It is shown that a simple, cut-based analysis is sufficient to improve the upper limit on this branching fraction within the lifetime of LHCb.

  7. Search for Neutral Minimal Supersymmetric Standard Model Higgs Bosons Decaying to Tau Pairs in pp Collisions at s=7TeV

    Microsoft Academic Search

    S. Chatrchyan; V. Khachatryan; A. M. Sirunyan; A. Tumasyan; W. Adam; T. Bergauer; M. Dragicevic; J. Erö; C. Fabjan; M. Friedl; R. Frühwirth; V. M. Ghete; J. Hammer; S. Hänsel; M. Hoch; N. Hörmann; J. Hrubec; M. Jeitler; G. Kasieczka; W. Kiesenhofer; M. Krammer; D. Liko; I. Mikulec; M. Pernicka; H. Rohringer; R. Schöfbeck; J. Strauss; F. Teischinger; P. Wagner; W. Waltenberger; G. Walzel; E. Widl; C.-E. Wulz; V. Mossolov; N. Shumeiko; J. Suarez Gonzalez; L. Benucci; E. A. de Wolf; X. Janssen; T. Maes; L. Mucibello; S. Ochesanu; B. Roland; R. Rougny; M. Selvaggi; H. van Haevermaet; P. van Mechelen; N. van Remortel; F. Blekman; S. Blyweert; J. D'Hondt; O. Devroede; R. Gonzalez Suarez; A. Kalogeropoulos; J. Maes; M. Maes; W. van Doninck; P. van Mulders; G. P. van Onsem; I. Villella; O. Charaf; B. Clerbaux; G. de Lentdecker; V. Dero; A. P. R. Gay; G. H. Hammad; T. Hreus; P. E. Marage; L. Thomas; C. Vander Velde; P. Vanlaer; V. Adler; A. Cimmino; S. Costantini; M. Grunewald; B. Klein; J. Lellouch; A. Marinov; J. McCartin; D. Ryckbosch; F. Thyssen; M. Tytgat; L. Vanelderen; P. Verwilligen; S. Walsh; N. Zaganidis; S. Basegmez; G. Bruno; J. Caudron; L. Ceard; E. Cortina Gil; J. de Favereau de Jeneret; C. Delaere; D. Favart; A. Giammanco; G. Grégoire; J. Hollar; V. Lemaitre; J. Liao; O. Militaru; S. Ovyn; D. Pagano; A. Pin; K. Piotrzkowski; N. Schul; N. Beliy; T. Caebergs; E. Daubie; G. A. Alves; D. de Jesus Damiao; M. E. Pol; M. H. G. Souza; W. Carvalho; E. M. da Costa; C. de Oliveira Martins; S. Fonseca de Souza; L. Mundim; H. Nogima; V. Oguri; W. L. Prado da Silva; A. Santoro; S. M. Silva Do Amaral; A. Sznajder; F. Torres da Silva de Araujo; F. A. Dias; T. R. Fernandez Perez Tomei; E. M. Gregores; C. Lagana; F. Marinho; P. G. Mercadante; S. F. Novaes; Sandra S. Padula; N. Darmenov; L. Dimitrov; V. Genchev; P. Iaydjiev; S. Piperov; M. Rodozov; S. Stoykova; G. Sultanov; V. Tcholakov; R. Trayanov; I. Vankov; A. Dimitrov; R. Hadjiiska; A. Karadzhinova; V. Kozhuharov; L. Litov; M. Mateev; B. Pavlov; P. Petkov; J. G. Bian; G. M. Chen; H. S. Chen; C. H. Jiang; D. Liang; S. Liang; X. Meng; J. Tao; J. Wang; X. Wang; Z. Wang; H. Xiao; M. Xu; J. Zang; Z. Zhang; Y. Ban; S. Guo; Y. Guo; W. Li; Y. Mao; S. J. Qian; H. Teng; L. Zhang; B. Zhu; W. Zou; A. Cabrera; B. Gomez Moreno; A. A. Ocampo Rios; A. F. Osorio Oliveros; J. C. Sanabria; N. Godinovic; D. Lelas; K. Lelas; R. Plestina; D. Polic; I. Puljak; Z. Antunovic; M. Dzelalija; V. Brigljevic; S. Duric; K. Kadija; S. Morovic; A. Attikis; M. Galanti; J. Mousa; C. Nicolaou; F. Ptochos; P. A. Razis; M. Finger; Y. Assran; S. Khalil; M. A. Mahmoud; A. Hektor; M. Kadastik; M. Müntel; M. Raidal; L. Rebane; V. Azzolini; P. Eerola; G. Fedi; S. Czellar; J. Härkönen; A. Heikkinen; V. Karimäki; R. Kinnunen; M. J. Kortelainen; T. Lampén; K. Lassila-Perini; S. Lehti; T. Lindén; P. Luukka; T. Mäenpää; E. Tuominen; J. Tuominiemi; E. Tuovinen; D. Ungaro; L. Wendland; K. Banzuzi; A. Korpela; T. Tuuva; D. Sillou; M. Besancon; S. Choudhury; M. Dejardin; D. Denegri; B. Fabbro; J. L. Faure; F. Ferri; S. Ganjour; F. X. Gentit; A. Givernaud; P. Gras; G. Hamel de Monchenault; P. Jarry; E. Locci; J. Malcles; M. Marionneau; L. Millischer; J. Rander; A. Rosowsky; I. Shreyber; M. Titov; P. Verrecchia; S. Baffioni; F. Beaudette; L. Benhabib; L. Bianchini; M. Bluj; C. Broutin; P. Busson; C. Charlot; T. Dahms; L. Dobrzynski; S. Elgammal; R. Granier de Cassagnac; M. Haguenauer; P. Miné; C. Mironov; C. Ochando; P. Paganini; D. Sabes; R. Salerno; Y. Sirois; C. Thiebaux; B. Wyslouch; A. Zabi; J.-L. Agram; J. Andrea; D. Bloch; D. Bodin; J.-M. Brom; M. Cardaci; E. C. Chabert; C. Collard; E. Conte; F. Drouhin; C. Ferro; J.-C. Fontaine; D. Gelé; U. Goerlach; S. Greder; P. Juillot; M. Karim; A.-C. Le Bihan; Y. Mikami; P. van Hove; F. Fassi; D. Mercier; C. Baty; S. Beauceron; N. Beaupere; M. Bedjidian; O. Bondu; G. Boudoul; D. Boumediene; H. Brun; R. Chierici; D. Contardo; P. Depasse; H. El Mamouni; J. Fay; S. Gascon; B. Ille; T. Kurca; T. Le Grand; M. Lethuillier; L. Mirabito; S. Perries; V. Sordini; S. Tosi; Y. Tschudi; P. Verdier; D. Lomidze; G. Anagnostou; M. Edelhoff; L. Feld; N. Heracleous; O. Hindrichs; R. Jussen; K. Klein; J. Merz; N. Mohr; A. Ostapchuk; A. Perieanu; F. Raupach; J. Sammet; S. Schael; D. Sprenger; H. Weber; M. Weber; B. Wittmer; M. Ata; W. Bender; E. Dietz-Laursonn; M. Erdmann; J. Frangenheim; T. Hebbeker; A. Hinzmann; K. Hoepfner; T. Klimkovich; D. Klingebiel; P. Kreuzer; D. Lanske; C. Magass; M. Merschmeyer; A. B. Meyer; P. Papacz; H. Pieta; H. Reithler; S. A. Schmitz; L. Sonnenschein; J. Steggemann; D. Teyssier; M. Tonutti; M. Bontenackels; M. Davids; M. Duda; G. Flügge; H. Geenen; M. Giffels; W. Haj Ahmad; D. Heydhausen; T. Kress; Y. Kuessel; A. Linn; A. Nowack; L. Perchalla; O. Pooth; J. Rennefeld; P. Sauerland; A. Stahl; M. Thomas

    2011-01-01

    A search for neutral minimal supersymmetric standard model (MSSM) Higgs bosons in pp collisions at the LHC at a center-of-mass energy of 7 TeV is presented. The results are based on a data sample corresponding to an integrated luminosity of 36pb-1 recorded by the CMS experiment. The search uses decays of the Higgs bosons to tau pairs. No excess is

  8. Phosphorylated Tau Can Promote Tubulin Assembly

    Microsoft Academic Search

    Huang-Chun Tseng; Quan Lu; Eric Henderson; Donald J. Graves

    1999-01-01

    Phosphorylation can affect the function of microtubule-associated protein tau. Here, the human brain tau with 441 amino acids was phosphorylated by cyclic-AMP-dependent protein kinase (PKA) or glycogen synthase kinase-3beta . PKA-phosphorylated tau (2.7 mol phosphates\\/mol) does not promote tubulin assembly as judged by spectrophotometric and atomic force microscopy measurements, unless trimethylamine N-oxide (TMAO), a natural occurring osmolyte, is included in

  9. Measurement of the branching fraction for $\\tau\\to\\eta K\

    SciTech Connect

    del Amo Sanchez, P.; Lees, J.P.; Poireau, V.; Prencipe, E.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Battaglia, M.; Brown, D.N.; Hooberman, B.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; Tanabe, T.; /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Indian Inst. Tech., Guwahati /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Paris U., VI-VII /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2011-08-12

    The authors report on analyses of tau lepton decays {tau}{sup -} {yields} {eta}K{sup -}{nu}{sub {tau}} and {tau}{sup -} {yields} {eta}{pi}{sup -}{nu}{sub {tau}}, with {eta} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup 0}, using 470 fb{sup -1} of data from the BABAR experiment at PEP-II, collected at center-of-mass energies at and near the {Upsilon}(4S) resonance. They measure the branching fraction for the {tau}{sup -} {yields} {eta}K{sup -}{nu}{sub {tau}} decay mode, {Beta}({tau}{sup -} {yields} {eta}K{sup -}{nu}{sub {tau}}) = (1.42 {+-} 0.11(stat) {+-} 0.07(syst)) x 10{sup -4}, and report a 95% confidence level upper limit for the second-class current process {tau}{sup -} {yields} {eta}{pi}{sup -}{nu}{sub {tau}}, {Beta}({tau}{sup -} {yields} {eta}{pi}{sup -}{nu}{sub {tau}}) < 9.9 x 10{sup -5}.

  10. A measurement of the tau Michel parameters at SLD

    SciTech Connect

    Quigley, J.

    1997-05-01

    This thesis presents a measurement of the tau Michel parameters. This measurement utilizes the highly polarized SLC electron beam to extract these quantities directly from the measured tau decay spectra using the 1993--95 SLD sample of 4,528 tau pair events. The results are {rho}{sup e} = 0.71 {+-} 0.14 {+-} 0.05, {xi}{sup e} = 1.16 {+-} 0.52 {+-} 0.06, and ({xi}{delta}){sup e} = 0.85 {+-} 0.43 {+-} 0.08 for tau decays to electrons and {rho}{sup {mu}} = 0.54 {+-} 0.28 {sup {minus}} 0.14, {eta}{sup {mu}} = {minus}0.59 {+-} 0.82 {+-} 0.45, {xi}{sup {mu}} = 0.75 {+-} 0.50 {+-} 0.14, and ({xi}{delta}){sup {mu}} = 0.82 {+-} 0.32 {+-} 0.07 for tau decays to muons. Combining all leptonic tau decays gives {rho} = 0.72 {+-} 0.09 {+-} 0.03, {xi} = 1.05 {+-} 0.35 {+-} 0.04, and {Xi}{delta} = 0.88 {+-} 0.27 {+-} 0.04. These results agree well with the current world average and the Standard Model.

  11. Tau imaging: early progress and future directions.

    PubMed

    Villemagne, Victor L; Fodero-Tavoletti, Michelle T; Masters, Colin L; Rowe, Christopher C

    2015-01-01

    Use of selective in-vivo tau imaging will enable improved understanding of tau aggregation in the brain, facilitating research into causes, diagnosis, and treatment of major tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. Neuropathological studies of Alzheimer's disease show a strong association between tau deposits, decreased cognitive function, and neurodegenerative changes. Selective tau imaging will allow the in-vivo exploration of such associations and measure the global and regional changes in tau deposits over time. Such imaging studies will comprise non-invasive assessment of the spatial and temporal pattern of tau deposition over time, providing insight into the role tau plays in ageing and helping to establish the relation between cognition, genotype, neurodegeneration, and other biomarkers. Once validated, selective tau imaging might be useful as a diagnostic, prognostic, and progression biomarker, and a surrogate marker for the monitoring of efficacy and patient recruitment for anti-tau therapeutic trials. PMID:25496902

  12. Tau regulates the subcellular localization of calmodulin

    SciTech Connect

    Barreda, Elena Gomez de [Centro de Biologia Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid (Spain)] [Centro de Biologia Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid (Spain); Avila, Jesus, E-mail: javila@cbm.uam.es [Centro de Biologia Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid (Spain) [Centro de Biologia Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid (Spain); CIBER de Enfermedades Neurodegenerativas, 28031 Madrid (Spain)

    2011-05-13

    Highlights: {yields} In this work we have tried to explain how a cytoplasmic protein could regulate a cell nuclear function. We have tested the role of a cytoplasmic protein (tau) in regulating the expression of calbindin gene. We found that calmodulin, a tau-binding protein with nuclear and cytoplasmic localization, increases its nuclear localization in the absence of tau. Since nuclear calmodulin regulates calbindin expression, a decrease in nuclear calmodulin, due to the presence of tau that retains it at the cytoplasm, results in a change in calbindin expression. -- Abstract: Lack of tau expression in neuronal cells results in a change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.

  13. Tau induces cooperative Taxol binding to microtubules

    PubMed Central

    Ross, Jennifer L.; Santangelo, Christian D.; Makrides, Victoria; Fygenson, D. Kuchnir

    2004-01-01

    Taxol and tau are two ligands that stabilize the microtubule (MT) lattice. Taxol is an anti-mitotic drug that binds ? tubulin in the MT interior. Tau is a MT-associated protein that binds both ? and ? tubulin on the MT exterior. Both Taxol and tau reduce MT dynamics and promote tubulin polymerization. Tau alone also acts to bundle, stiffen, and space MTs. A structural study recently suggested that Taxol and tau may interact by binding to the same site. Using fluorescence recovery after photobleaching, we find that tau induces Taxol to bind MTs cooperatively depending on the tau concentration. We develop a model that correctly fits the data in the absence of tau, yields the equilibrium dissociation constant of ?2 ?M, and determines the escape rate of Taxol through one pore to be 1.7 × 103 (M·s)–1. Extension of the model yields a measure of Taxol cooperativity with a Hill coefficient of at least 15 when tau is present at a 1:1 molar ratio with tubulin. PMID:15326286

  14. Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice

    E-print Network

    Halverson, Robyn A.; Lewis, Jada; Frausto, Shanti; Hutton, Mike; Muma, Nancy A.

    2005-02-02

    . To further determine the contribution of transglutaminase in the formation of NFTs, we compared the levels of cross-linked tau protein from P301L tau transgenic mice that develop NFTs to four-repeat wild-type (4RWT) tau transgenic and nontransgenic mice...

  15. Measurement of the tau lepton polarisation at LEP2

    NASA Astrophysics Data System (ADS)

    Abdallah, J.; Abreu, P.; Adam, W.; Adzic, P.; Albrecht, T.; Alemany-Fernandez, R.; Allmendinger, T.; Allport, P. P.; Amaldi, U.; Amapane, N.; Amato, S.; Anashkin, E.; Andreazza, A.; Andringa, S.; Anjos, N.; Antilogus, P.; Apel, W.-D.; Arnoud, Y.; Ask, S.; Asman, B.; Augustin, J. E.; Augustinus, A.; Baillon, P.; Ballestrero, A.; Bambade, P.; Barbier, R.; Bardin, D.; Barker, G. J.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.-H.; Begalli, M.; Behrmann, A.; Ben-Haim, E.; Benekos, N.; Benvenuti, A.; Berat, C.; Berggren, M.; Bertrand, D.; Besancon, M.; Besson, N.; Bloch, D.; Blom, M.; Bluj, M.; Bonesini, M.; Boonekamp, M.; Booth, P. S. L.; Borisov, G.; Botner, O.; Bouquet, B.; Bowcock, T. J. V.; Boyko, I.; Bracko, M.; Brenner, R.; Brodet, E.; Bruckman, P.; Brunet, J. M.; Buschbeck, B.; Buschmann, P.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Castro, N.; Cavallo, F.; Chapkin, M.; Charpentier, Ph.; Checchia, P.; Chierici, R.; Chliapnikov, P.; Chudoba, J.; Chung, S. U.; Cieslik, K.; Collins, P.; Contri, R.; Cosme, G.; Cossutti, F.; Costa, M. J.; Crennell, D.; Cuevas, J.; D'Hondt, J.; da Silva, T.; da Silva, W.; Dedovich, D.; Ricca, G. Della; de Angelis, A.; de Boer, W.; de Clercq, C.; de Lotto, B.; de Maria, N.; de Min, A.; de Paula, L.; di Ciaccio, L.; di Simone, A.; Doroba, K.; Drees, J.; Eigen, G.; Ekelof, T.; Ellert, M.; Elsing, M.; Santo, M. C. Espirito; Fanourakis, G.; Fassouliotis, D.; Feindt, M.; Fernandez, J.; Ferrer, A.; Ferro, F.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fulda-Quenzer, F.; Fuster, J.; Gandelman, M.; Garcia, C.; Gavillet, Ph.; Gazis, E.; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Graziani, E.; Grosdidier, G.; Grzelak, K.; Guy, J.; Haag, C.; Hallgren, A.; Hamacher, K.; Hamilton, K.; Haug, S.; Hauler, F.; Hedberg, V.; Hennecke, M.; Herr, H.; Hoffman, J.; Holmgren, S.-O.; Holt, P. J.; Houlden, M. A.; Jackson, J. N.; Jarlskog, G.; Jarry, P.; Jeans, D.; Johansson, E. K.; Jonsson, P.; Joram, C.; Jungermann, L.; Kapusta, F.; Katsanevas, S.; Katsoufis, E.; Kernel, G.; Kersevan, B. P.; Kerzel, U.; King, B. T.; Kjaer, N. J.; Kluit, P.; Kokkinias, P.; Kourkoumelis, C.; Kouznetsov, O.; Krumstein, Z.; Kucharczyk, M.; Lamsa, J.; Leder, G.; Ledroit, F.; Leinonen, L.; Leitner, R.; Lemonne, J.; Lepeltier, V.; Lesiak, T.; Liebig, W.; Liko, D.; Lipniacka, A.; Lopes, J. H.; Lopez, J. M.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Malek, A.; Maltezos, S.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.-C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Mazzucato, F.; Mazzucato, M.; Nulty, R. Mc; Meroni, C.; Migliore, E.; Mitaroff, W.; Mjoernmark, U.; Moa, T.; Moch, M.; Moenig, K.; Monge, R.; Montenegro, J.; Moraes, D.; Moreno, S.; Morettini, P.; Mueller, U.; Muenich, K.; Mulders, M.; Mundim, L.; Murray, W.; Muryn, B.; Myatt, G.; Myklebust, T.; Nassiakou, M.; Navarria, F.; Nawrocki, K.; Nicolaidou, R.; Nikolenko, M.; Oblakowska-Mucha, A.; Obraztsov, V.; Olshevski, A.; Onofre, A.; Orava, R.; Osterberg, K.; Ouraou, A.; Oyanguren, A.; Paganoni, M.; Paiano, S.; Palacios, J. P.; Palka, H.; Papadopoulou, Th. D.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Peralta, L.; Perepelitsa, V.; Perrotta, A.; Petrolini, A.; Piedra, J.; Pieri, L.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Poireau, V.; Pol, M. E.; Polok, G.; Pozdniakov, V.; Pukhaeva, N.; Pullia, A.; Rames, J.; Read, A.; Rebecchi, P.; Rehn, J.; Reid, D.; Reinhardt, R.; Renton, P.; Richard, F.; Ridky, J.; Rivero, M.; Rodriguez, D.; Romero, A.; Ronchese, P.; Roudeau, P.; Rovelli, T.; Ruhlmann-Kleider, V.; Ryabtchikov, D.; Sadovsky, A.; Salmi, L.; Salt, J.; Sander, C.; Savoy-Navarro, A.; Schwickerath, U.; Sekulin, R.; Siebel, M.; Sisakian, A.; Smadja, G.; Smirnova, O.; Sokolov, A.; Sopczak, A.; Sosnowski, R.; Spassov, T.; Stanitzki, M.; Stocchi, A.; Strauss, J.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Szumlak, T.; Tabarelli, T.; Tegenfeldt, F.; Timmermans, J.; Tkatchev, L.; Tobin, M.; Todorovova, S.; Tome, B.; Tonazzo, A.; Tortosa, P.; Travnicek, P.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Turluer, M.-L.; Tyapkin, I. A.; Tyapkin, P.; Tzamarias, S.; Uvarov, V.; Valenti, G.; van Dam, P.; van Eldik, J.; van Remortel, N.; van Vulpen, I.; Vegni, G.; Veloso, F.; Venus, W.; Verdier, P.; Verzi, V.; Vilanova, D.; Vitale, L.; Vrba, V.; Wahlen, H.; Washbrook, A. J.; Weiser, C.; Wicke, D.; Wickens, J.; Wilkinson, G.; Winter, M.; Witek, M.; Yushchenko, O.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zhuravlov, V.; Zimin, N. I.; Zintchenko, A.; Zupan, M.; Delphi Collaboration

    2008-01-01

    A first measurement of the average polarisation P? of tau leptons produced in e+e- annihilation at energies significantly above the Z resonance is presented. The polarisation is determined from the kinematic spectra of tau hadronic decays. The measured value P? = - 0.164 ± 0.125 is consistent with the Standard Model prediction for the mean LEP energy of 197 GeV.

  16. A measurement of the lifetime of the tau lepton

    Microsoft Academic Search

    P. Abreu; W. Adam; F. Adami; T. Adye; T. Akesson; G. D. Alekseev; P. Allen; S. Almehed; S. J. Alvsvaag; Ugo Amaldi; E G Anassontzis; P. Antilogus; W.-D. Apel; R.-J. Apsimon; B. Åsman; Pierre Astier; J.-E. Augustin; A. Augustinus; Paul Baillon; P. Bambade; F. Barao; Guido Barbiellini; Dimitri Yuri Bardin; A. Baroncelli; O. Barring; Walter Bartl; Marco Battaglia; M. J. Bates; M. Baubillier; K.-H. Becks; C. J. Beeston; M. Begalli; P. Beilliere; Yu A Belokopytov; P. Beltran; D. Benedic; J. M. Benlloch; M. Berggren; D. Bertrand; F. Bianchi; J. H. Bibby; M. S. Bilenky; P. Billoir; J. Bjarne; D. Bloch; S. Blyth; P. N. Bogolubov; T. Bolognese; M. Bonapart; M. Bonesini; W. Bonivento; P. S. L. Booth; M. Boratav; P. Borgeaud; G. Borisov; H. Borner; C. Bosio; B. Bostjancic; O. Botner; B. Bouquet; M. Bozzo; S. Braibant; P. Branchini; K. D. Brand; R. A. Brenner; C. Bricman; R. C. A. Brown; N. Brummer; J.-M. Brunet; L. Bugge; T. Buran; H. Burmeister; J. A. M. A. Buytaert; M. Caccia; M. Calvi; A. J. Camacho Rozas; J.-E. Campagne; A. Campion; T. Camporesi; V. Canale; F. Cao; F. Carena; L. Carroll; Carlo Caso; Edoardo Castelli; M. V. Castillo Gimenez; A. Cattai; F. R. Cavallo; L. Cerrito; A. Chan; P. Charpentier; P. Checchia; G. A. Chelkov; L. Chevalier; P V Chliapnikov; V. Chorowicz; R. Cirio; M. P. Clara; P. Collins; J. L. Contreras; R. Contri; G. Cosme; F. Couchot; H. B. Crawley; D J Crennell; G. Crosetti; N. Crosland; M. Crozon; J. Cuevas Maestro; S. Czellar; S. Dagoret; Erik Dahl-Jensen; B. Dalmagne; M. Dam; G. Damgaard; G. Darbo; Evelyne Daubie; P. D. Dauncey; Martyn Davenport; P. David; A. de Angelis; M. de Beer; H. de Boeck; Wim de Boer; C. de Clercq; M. D. M. de Fez Laso; N. de Groot; C. de La Vaissiere; B. de Lotto; A. de Min; C. Defoix; D. Delikaris; S. Delorme; P A Delpierre; N. Demaria; J E Derkaoui; Lucia Di Ciaccio; H. Dijkstra; F. Djama; J. Dolbeau; M. Donszelmann; K. Doroba; M. Dracos; J. Drees; M. Dris; Y. Dufour; W. Dulinski; L.-O. Eek; Paule Anna Mari Eerola; T J C Ekelöf; Gösta Ekspong; A. Elliot Peisert; J.-P. Engel; V P Falaleev; D. Fassouliotis; M. Fernandez Alonso; A. Ferrer; T. A. Filippas; A. Firestone; H. Foeth; E. Fokitis; P. Folegati; F. Fontanelli; K. A. J. Forbes; H. Forsbach; B J Franek; P. Frenkiel; D E C Fries; A. G. Frodesen; R. Fruhwirth; F. Fulda-Quenzer; K. Furnival; H. Furstenau; J A Fuster; J. M. Gago; G. Galeazzi; D. Gamba; C. Garcia; J. Garcia; U. Gasparini; P. Gavillet; E. N. Gazos; J.-P. Gerber; P. Giacomelli; K.-W. Glitza; R. Gokieli; V. M. Golovatyuk; J. J. Gomez Y Cadenas; A. Goobar; Gian P Gopal; M. Gorski; Valerio Gracco; A. Grant; F. Grard; E. Graziani; M.-H. Gros; G. Grosdidier; E. Gross; B. Grossetete; S A Gumenyuk; J. Guy; F. Hahn; M. Hahn; S. Haider; Z. Hajduk; A. Hakansson; A. Hallgren; K. Hamacher; G. Hamel de Monchenault; F. J. Harris; B. W. Heck; T. Henkes; I. Herbst; J. J. Hernandez; P. Herquet; H. Herr; I. Hietanen; C. O. Higgins; E. Higon; H. J. Hilke; S. D. Hodgson; T. Hofmokl; R. Holmes; S.-O. Holmgren; D. Holthuizen; P. F. Honore; J. E. Hooper; R. Horisberger; M. Houlden; J. Hrubec; P. O. Hulth; K. Hultqvist; D. Husson; B. D. Hyams; P. Ioannou; D. Isenhower; P.-S. Iversen; J. N. Jackson; P. Jalocha; G. Jarlskog; P. Jarry; B. Jean-Marie; E. K. Johansson; D. Johnson; M. Jonker; L. Jonsson; P. Juillot; G. Kalkanis; G Kantardjian; F. Kapusta; S. Katsanevas; E. C. Katsoufis; R. Keranen; J. Kesteman; B. A. Khomenko; N. N. Khovanski; B. King; N. J. Kjaer; H. Klein; W. Klempt; A. Klovning; P. Kluit; J. H. Koehne; B. Koene; P. Kokkinias; M Koratzinos; M. Koratzinos; K. Korcyl; A. V. Korytov; B. Korzen; V. Kostukhin; C. Kourkoumelis; T. Kreuzberger; J. Krolikowski; U. Kruener-Marquis; W. Krupinski; W. Kucewicz; K. Kurvinen; C Lambropoulos; J. W. Lamsa; L. Lanceri; V. Lapin; J.-P. Laugier; R. Lauhakangas; G. Leder; F. Ledroit; J. Lemonne; G. Lenzen; V. Lepeltier; A. Letessier-Selvon; D. Liko; E Lillethun; J. Lindgren; A. Lipniacka; I. Lippi; R. Llosa; B. Loerstad; M. Lokajicek; J. G. Loken; M. A. Lopez Aguera; A. Lopez-Fernandez; M. Los; D. Loukas; A. Lounis; J. J. Lozano; R. Lucock; P. Lutz; L. Lyons; G. Maehlum; J. Maillard; A. Maltezos; S. Maltezos; F. Mandl; J. Marco; M. Margoni; J.-C. Marin; A. Markou; S. Marti; L. Mathis; F. Matorras; C. Matteuzzi; G. Matthiae; M Mazzucato; M. Mc Cubbin; R. Mc Nulty; E. Menichetti; G. Meola; C. Meroni; W. T. Meyer; M. Michelotto; W. A. Mitaroff; G. V. Mitselmakher; U. Mjoernmark; T. Moa; R. Moeller; K. Moenig; M. R. Monge; P. Morettini; H. Mueller; H. Muller; W. J. Murray; G. Myatt; F. Naraghi; U. Nau-Korzen; F. L. Navarria; P. Negri; B. S. Nielsen; B. Nijjhar; V. Nikolaenko; V. Obraztsov; A. G. Olshevski; R. Orava; A. Ostankov; A. Ouraou; R. Pain; H. Palka; T. Papadopoulou; L. Pape; A. Passeri; M. Pegoraro; V. Perevozchikov; M. Pernicka; A. Perrotta

    1991-01-01

    The lifetime of the tau lepton has been measured by two independent methods using a silicon microvertex detector installed in the DELPHI detector. The signed impact parameter distribution of the one prong decays yielded a lifetime of tautau = 321 +\\/- 36 (stat.) +\\/- 16 (syst.) fs, while the decay length distribution of three prong decays gave the result tautau

  17. Searches for Lepton Flavor Violation in the Decays tau[superscript ±]-->e[superscript ±]gamma and tau[superscript ±]-->mu[superscript ±]gamma

    E-print Network

    Cowan, Ray Franklin

    Searches for lepton-flavor-violating decays of a ? lepton to a lighter mass lepton and a photon have been performed with the entire data set of (963±7)×10[superscript 6]?? decays collected by the BABAR detector near the ...

  18. Physics with tau leptons at CDF

    SciTech Connect

    Hays, C.P.; /Oxford U.

    2007-04-01

    The {radical}s = 1.96 TeV p{bar p} collisions produced by the Tevatron result in many processes with tau leptons in the final state. The CDF Collaboration has studied these final states in Z and t{bar t} production, and has used tau leptons to search for evidence of Higgs, sparticle, and Z{prime} production.

  19. Tau-Equivalence and Equipercentile Equating.

    ERIC Educational Resources Information Center

    Yen, Wendy M.

    1983-01-01

    Tau-equivalence means that two tests produce equal true scores for individuals but that the distribution of errors for the tests could be different. This paper examines the effect of performing equipercentile equating techniques on tau-equivalent tests. (JKS)

  20. Status of the tau one prong problem

    SciTech Connect

    Hayes, K.G.

    1989-08-01

    The present status of the tau one prong problem is reviewed. Emphasis is placed on recent published branching fraction measurements, the status and implications of tau lifetime measurements, and measurements which constrain the sum of branching fractions to be unity. 29 refs., 10 figs., 2 tabs.

  1. Search for MSSM Higgs decaying to tau pairs in proton-antiproton collision at center of mass energy = 1.96 TeV at CDF

    NASA Astrophysics Data System (ADS)

    Jang, Dongwook

    This thesis presents the search for neutral Minimal Supersymmetric extension of Standard Model(MSSM) Higgs bosons decaying to tau pairs where one of the taus decays leptonically, and the other one hadronically. CDF Run II data with L int = 310 pb-1 are used. There is no evidence of MSSM Higgs existance, which results in the upper limits on sigma(pp¯ ? ?) x BR(? ? tautau) in mA range between 115 and 250 GeV. These limits exclude some area in tan beta vs. mA parameter space.

  2. Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.

    PubMed

    Ishihara, T; Zhang, B; Higuchi, M; Yoshiyama, Y; Trojanowski, J Q; Lee, V M

    2001-02-01

    Intraneuronal filamentous tau inclusions such as neurofibrillary tangles (NFTs) are neuropathological hallmarks of Alzheimer's disease (AD) and related sporadic and familial tauopathies. NFTs identical to those found in AD brains have also been detected in the hippocampus and entorhinal cortex of cognitively normal individuals as they age. To recapitulate age-induced NFT formation in a mouse model, we examined 12- to 24-month-old transgenic (Tg) mice overexpressing the smallest human brain tau isoform. These Tg mice develop congophilic tau inclusions in several brain regions including the hippocampus, amygdala, and entorhinal cortex. NFT-like inclusions were first detected in Tg mice at 18 to 20 months of age and they were detected by histochemical dyes that bind specifically to crossed beta-pleated sheet structures (eg, Congo red, Thioflavin S). Moreover, ultrastructurally these lesions contained straight tau filaments comprised of both mouse and human tau proteins but not other cytoskeletal proteins (eg, neurofilaments, microtubules). Isolated tau filaments were also recovered from detergent-insoluble tau fractions and insoluble tau proteins accumulated in brain in an age-dependent manner. Thus, overexpression of the smallest human brain tau isoform resulted in late onset and age-dependent formation of congophilic tau inclusions with properties similar to those in the tangles of human tauopathies, thereby implicating aging in the pathogenesis of fibrous tau inclusions. PMID:11159192

  3. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

    PubMed Central

    Luo, Wenjie; Liu, Wencheng; Hu, Xiaoyan; Hanna, Mary; Caravaca, April; Paul, Steven M.

    2015-01-01

    Microglia have been shown to contribute to the clearance of brain amyloid ? peptides (A?), the major component of amyloid plaques, in Alzheimer’s disease (AD). However, it is not known whether microglia play a similar role in the clearance of tau, the major component of neurofibrillary tangles (NFTs). We now report that murine microglia rapidly internalize and degrade hyperphosphorylated pathological tau isolated from AD brain tissue in a time-dependent manner in vitro. We further demonstrate that microglia readily degrade human tau species released from AD brain sections and eliminate NFTs from brain sections of P301S tauopathy mice. The anti-tau monoclonal antibody MC1 enhances microglia-mediated tau degradation in an Fc-dependent manner. Our data identify a potential role for microglia in the degradation and clearance of pathological tau species in brain and provide a mechanism explaining the potential therapeutic actions of passively administered anti-tau monoclonal antibodies. PMID:26057852

  4. Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model.

    PubMed

    Castillo-Carranza, Diana L; Guerrero-Muñoz, Marcos J; Sengupta, Urmi; Hernandez, Caterina; Barrett, Alan D T; Dineley, Kelly; Kayed, Rakez

    2015-03-25

    In Alzheimer's disease (AD), the pathological accumulation of tau appears to be a downstream effect of amyloid ? protein (A?). However, the relationship between these two proteins and memory loss is unclear. In this study, we evaluated the specific removal of pathological tau oligomers in aged Tg2576 mice by passive immunotherapy using tau oligomer-specific monoclonal antibody. Removal of tau oligomers reversed memory deficits and accelerated plaque deposition in the brain. Surprisingly, A?*56 levels decreased, suggesting a link between tau and A? oligomers in the promotion of cognitive decline. The results suggest that tau oligomerization is not only a consequence of A? pathology but also a critical mediator of the toxic effects observed afterward in AD. Overall, these findings support the potential of tau oligomers as a therapeutic target for AD. PMID:25810517

  5. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics.

    PubMed

    Rosseels, Joëlle; Van den Brande, Jeff; Violet, Marie; Jacobs, Dirk; Grognet, Pierre; Lopez, Juan; Huvent, Isabelle; Caldara, Marina; Swinnen, Erwin; Papegaey, Anthony; Caillierez, Raphaëlle; Buée-Scherrer, Valerie; Engelborghs, Sebastiaan; Lippens, Guy; Colin, Morvane; Buée, Luc; Galas, Marie-Christine; Vanmechelen, Eugeen; Winderickx, Joris

    2015-02-13

    A link between Tau phosphorylation and aggregation has been shown in different models for Alzheimer disease, including yeast. We used human Tau purified from yeast models to generate new monoclonal antibodies, of which three were further characterized. The first antibody, ADx201, binds the Tau proline-rich region independently of the phosphorylation status, whereas the second, ADx215, detects an epitope formed by the Tau N terminus when Tau is not phosphorylated at Tyr(18). For the third antibody, ADx210, the binding site could not be determined because its epitope is probably conformational. All three antibodies stained tangle-like structures in different brain sections of THY-Tau22 transgenic mice and Alzheimer patients, and ADx201 and ADx210 also detected neuritic plaques in the cortex of the patient brains. In hippocampal homogenates from THY-Tau22 mice and cortex homogenates obtained from Alzheimer patients, ADx215 consistently stained specific low order Tau oligomers in diseased brain, which in size correspond to Tau dimers. ADx201 and ADx210 additionally reacted to higher order Tau oligomers and presumed prefibrillar structures in the patient samples. Our data further suggest that formation of the low order Tau oligomers marks an early disease stage that is initiated by Tau phosphorylation at N-terminal sites. Formation of higher order oligomers appears to require additional phosphorylation in the C terminus of Tau. When used to assess Tau levels in human cerebrospinal fluid, the antibodies permitted us to discriminate patients with Alzheimer disease or other dementia like vascular dementia, indicative that these antibodies hold promising diagnostic potential. PMID:25540200

  6. An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

    PubMed Central

    Cavallini, Annalisa; Brewerton, Suzanne; Bell, Amanda; Sargent, Samantha; Glover, Sarah; Hardy, Clare; Moore, Roger; Calley, John; Ramachandran, Devaki; Poidinger, Michael; Karran, Eric; Davies, Peter; Hutton, Michael; Szekeres, Philip; Bose, Suchira

    2013-01-01

    Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia. Identifying the kinases involved in the pathological phosphorylation of tau may identify novel targets for AD. We used an unbiased approach to study the effect of 352 human kinases on their ability to phosphorylate tau at epitopes associated with AD. The kinases were overexpressed together with the longest form of human tau in human neuroblastoma cells. Levels of total and phosphorylated tau (epitopes Ser(P)-202, Thr(P)-231, Ser(P)-235, and Ser(P)-396/404) were measured in cell lysates using AlphaScreen assays. GSK3?, GSK3?, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes. We further dissected the effects of GSK3? and GSK3? using pharmacological and genetic tools in hTau primary cortical neurons. Pathway analysis of the kinases identified in the screen suggested mechanisms for regulation of total tau levels and tau phosphorylation; for example, kinases that affect total tau levels do so by inhibition or activation of translation. A network fishing approach with the kinase hits identified other key molecules putatively involved in tau phosphorylation pathways, including the G-protein signaling through the Ras family of GTPases (MAPK family) pathway. The findings identify novel tau kinases and novel pathways that may be relevant for AD and other tauopathies. PMID:23798682

  7. Results of magnetic field measurements in young stars DO Tau, DR Tau, and DS Tau

    NASA Astrophysics Data System (ADS)

    Dodin, A. V.; Lamzin, S. A.; Chuntonov, G. A.

    2013-04-01

    The results of longitudinal magnetic field measurements B z in the hot accretion spot in three classical T Tauri stars (CTTS) are reported. In all three stars the magnetic field is detected at a level above 2 ? in the formation region of the narrow component of the He I 5876 Å emission line. In the case of DS Tau the longitudinal field B z in the hot spot was also measured from the narrow emission components of the Na I D lines, implying +0.8 ± 0.3 kG, which is equal to the B z field component measured from the He I 5876 Å line. Our results suggest that the 6-m telescope of the Special Astrophysical Observatory can be used to study magnetic fields in the hot spots of CTTS with magnitudes down to 13m, making it possible to double the number of stars of this type with measured B z values in the accretion zone.

  8. Measurement of the topological branching fractions of the tau lepton

    SciTech Connect

    Akerlof, C.; Baranko, G.; Baringer, P.; Beltrami, I.; Blockus, D.; Bonvicini, G.; Brabson, B.; Bylsma, B.G.; Chapman, J.; Cork, B.

    1985-08-05

    We report new and precise measurements of the decay branching fractions of the tau lepton to one and three charged particles. The data, corresponding to an integrated luminosity of 176 pb/sup -1/, were collected by the High Resolution Spectrometer at the e/sup +/e/sup -/ storage ring PEP at SLAC operated at ..sqrt..s = 29 GeV. The fractions of tau decays into one and three charged particles are 0.869 +- 0.002 +- 0.003 and 0.130 +- 0.002 +- 0.003, respectively.

  9. Determination of the Higgs CP mixing angle in the tau decay channels at the LHC including the Drell-Yan background

    E-print Network

    Stefan Berge; Werner Bernreuther; Sebastian Kirchner

    2014-12-10

    We investigate how precisely the CP nature of the 125 GeV Higgs boson resonance h can be unraveled at the LHC in its decays to tau pairs. We use a method which allows to determine the scalar-pseudoscalar Higgs mixing angle in this decay mode. This mixing angle can be extracted from the distribution of a signed angle, which we analyze for the major charged-prong tau decays. For definiteness, we consider Higgs-boson production by gluon fusion at NLO QCD. We take into account also the irreducible background from Drell-Yan production at NLO QCD. We compute, for the signal and background reactions, angular and energy correlations of the charged prongs and analyze which type of cuts suppress the Drell-Yan background. An important feature of this background is that its contribution to the distribution of our observable is a flat line, also at NLO QCD. By separating the Drell-Yan events into two different sets, two different non-trivial distributions are obtained. Based on this observation we propose to use these sets for calibation purposes. By Monte Carlo simulation we study also the effect of measurement uncertainties on this distribution. We estimate that the Higgs mixing angle can be determined with our method to a precision of 14 degree (5 degree) at the high luminosity LHC (14 TeV) with an integrated luminosity of 500 inverse fb (3 inverse ab).

  10. Variation in tau, the time constant for isovolumic relaxation, along the left ventricular base-to-apex axis.

    PubMed

    Davis, K L; Mehlhorn, U; Schertel, E R; Geissler, H J; Trevas, D; Laine, G A; Allen, S J

    1999-02-01

    Tau (tau), the time constant for isovolumic relaxation, is often used as a measure of cardiac diastolic function. However, several methods of calculating tau have been published which may produce different results and, thereby, different conclusions. The purpose of this study was to determine if the method of tau calculation effects the results when left ventricular pressure (LVP) is measured at different positions along the base-to-apex axis. In 16 dogs, we measured LVP at 6 positions along the base-to-apex axis. We calculated tau using three different methods: 1) a monoexponential model (P(t) = [P0-Pasym]eAt + Pasym, where t = time, P0 = LVP at t = 0, Pasym is asymptotic pressure as t-->infinity, A is -1/tau) with a zero asymptote 2) a monoexponential model with a variable asymptote in which the monoexponential decay equation is differentiated with respect to time and substituted into the original equation so that dP/dt vs. LVP is A (-1/tau), and 3) a monoexponential decay model with variable asymptote in which Pasym and A are varied until the best fit line is reached by minimizing the residual sum of squares. When tau is calculated using method 1, tau measured at the LV base is 98.01% +/- 8.85% of tau at the apex. If calculated using method 2, tau measured at the LV base was 75.46 +/- 39.4% of tau measured at the apex. When method 3 is used for tau calculations, base tau increases to 117.76 +/- 4.91% of the apical tau. We conclude: 1) the method used to calculate tau will effect the results and, thus, conclusions drawn from tau data. 2) When using Method 3, which appears to be the best method for tau calculation, tau increases at the LV base compared to the apex. PMID:10097829

  11. Recent Results on Charm and Tau Physics from BaBar And Belle

    SciTech Connect

    Salvatore, Fabrizio F.; /Royal Holloway, U. of London

    2007-10-15

    Recent results on charm and tau physics obtained at the BABAR and Belle experiments are presented in this article. The charm section will be focused on the most recent results on D{sup 0}{bar D}{sup 0} mixing at Belle and on the measurement of the pseudoscalar decay constant f{sub Ds} using charm tagged e+e- events at BABAR. In the tau section the recent results on Lepton Flavor Violation from tau decays will be discussed, as well as the recent result on the rare decay {tau}{sup -} {yields} 3{pi}{sup -}2{pi}{sup +}2{pi}{sup 0}{nu}{sub {tau}} at BABAR and the measurement of the {tau} lepton mass at Belle.

  12. Discovering the Higgs Bosons of Minimal Supersymmetry with Tau Leptons and a Bottom Quark

    E-print Network

    Chung Kao; Duane Dicus; Rahul Malhotra; Yili Wang

    2007-11-02

    We investigate the prospects for the discovery at the CERN Large Hadron Collider or at the Fermilab Tevatron of neutral Higgs bosons through the channel where the Higgs are produced together with a single bottom quark and the Higgs decays into a pair of tau leptons, $bg \\to b\\phi^0 \\to b\\tau^+\\tau^-, \\phi^0 = h^0, H^0, A^0$. We work within the framework of the minimal supersymmetric model. The dominant physics background from the production of $b\\tau^+\\tau^-$, $j\\tau^+\\tau^-$ ($j = g, u, d, s, c$), $b\\bar{b}W^+W^-$, $W+2j$ and $Wbj$ is calculated with realistic acceptance cuts and efficiencies. Promising results are found for the CP-odd pseudoscalar ($A^0$) and the heavier CP-even scalar ($H^0$) Higgs bosons with masses up to one TeV.

  13. Reconstruction of {tau}-tilde{sub 1} mass at the LHC

    SciTech Connect

    Djilkibaev, R. M.; Konoplich, R. V., E-mail: rk60@nyu.edu [New York University, Department of Physics (United States)

    2011-01-15

    The cascade mass reconstruction approach was used for mass reconstruction of the lightest {tau}-tilde produced at the LHC in the cascade decay g-tilde {yields} b-tildeb {yields} {chi}-tilde{sub 2}{sup 0}bb {yields} {tau}-tilde{sub 1}{tau}bb {yields} {chi}-tilde{sub 1}{sup 0}{tau}{tau}bb. The {tau}-tilde{sub 1} mass was reconstructed assuming that masses of gluino, bottom squark, and two lightest neutralinos were reconstructed in advance. SUSY data sample sets for the SU(3) model point containing 160k events each were generated which corresponded to an integrated luminosity of about 8 fb{sup -1} at 14 TeV. These events were passed through the AcerDET detector simulator, which parametrized the response of a generic LHC detector. The mass of the {tau}-tilde{sub 1} was reconstructed with a precision of about 20% on average.

  14. Lepton flavor violating Higgs bosons and {tau}{yields}{mu}{gamma}

    SciTech Connect

    Davidson, Sacha; Grenier, Gerald [IPNL, Universite de Lyon, Universite Lyon 1, CNRS/IN2P3, 4 rue E. Fermi 69622 Villeurbanne cedex (France)

    2010-05-01

    We update phenomenological constraints on a two Higgs doublet model with lepton flavor nonconserving Yukawa couplings. We review that tan{beta} is ambiguous in such 'type III' models, and define it from the {tau} Yukawa coupling. The neutral scalars {phi} could be searched for at hadron colliders in {phi}{yields}{tau}{mu} and are constrained by the rare decay {tau}{yields}{mu}{gamma}. The Feynman diagrams for the collider process, with Higgs production via gluon fusion, are similar to the two-loop ''Barr-Zee'' diagrams, which contribute to {tau}{yields}{mu}{gamma}. Some ''tuning'' is required to obtain a collider cross section of order the standard model expectation for {sigma}(gg{yields}h{sub SM{yields}{tau}}{sup +{tau}-}), while agreeing with the current bound from {tau}{yields}{mu}{gamma}.

  15. Upper limits to. nu. /sub. mu. /-. nu. /sub tau/ oscillation and. nu. /sub. mu. /-tau coupling

    SciTech Connect

    Ushida, N.; Kondo, T.; Fujioka, G.; Fukushima, H.; Takahashi, Y.; Tatsumi, S.; Yokoyama, C.; Homma, Y.; Tsuzuki, Y.; Bahk, S.; Kim, C.; Park, J.; Song, J.; Bailey, D.; Conetti, S.; Fischer, J.; Trischuk, J.; Fuchi, H.; Hoshino, K.; Miyanishi, M.; Niu, K.; Niwa, K.; Shibuya, H.; Yanagisawa, Y.; Errede, S.; Gutzwiller, M.; Kuramata, S.; Reay, N.W.; Reibel, K.; Romanowski, T.A.; Sidwell, R.; Stanton, N.R.; Moriyama, K.; Shibata, H.; Hara, T.; Kusumoto, O.; Noguchi, Y.; Teranaka, M.; Okabe, H.; Yokota, J.; Harnois, J.; Hebert, C.; Hebert, J.; Lokanathan, S.; McLeod, B.; Tasaka, S.; Davis, P.; Martin, J.; Pitman, D.; Prentice, J.D.; Sinervo, P.; Yoon, T.S.; Kimura, H.; Maeda, Y.

    1981-12-14

    A search for tau lepton production in a sample of 1241 neutrino interactions with use of a hybrid emulsion spectrometer in the Fermilab wide-band neutrino beam is reported. No such events are seen and an upper limit to the ..nu../sub ..mu../-tau coupling of 0.63% (90% C.L.) is set. For ..nu../sub ..mu../-..nu../sub tau/ oscillations this sets a limit of Vertical Barm/sup 2/..mu..-m/sup 2/tauVertical Bar<3.0 eV/sup 2/ (90% C.L.) for maximum mixing.

  16. Exclusive Branching-Fraction Measurements of Semileptonic tau Decays into Three Charged Hadrons, into phipi-nutau, and into phiK-nutau

    Microsoft Academic Search

    B. Aubert; M. Bona; D. Boutigny; F. Couderc; Y. Karyotakis; J. P. Lees; V. Poireau; V. Tisserand; A. Zghiche; E. Grauges; A. Palano; J. C. Chen; N. D. Qi; G. Rong; P. Wang; Y. S. Zhu; G. Eigen; I. Ofte; B. Stugu; G. S. Abrams; M. Battaglia; D. N. Brown; J. Button-Shafer; R. N. Cahn; E. Charles; M. S. Gill; Y. Groysman; R. G. Jacobsen; J. A. Kadyk; L. T. Kerth; Yu. G. Kolomensky; G. Kukartsev; D. Lopes Pegna; G. Lynch; L. M. Mir; T. J. Orimoto; M. Pripstein; N. A. Roe; M. T. Ronan; W. A. Wenzel; P. Del Amo Sanchez; M. Barrett; K. E. Ford; T. J. Harrison; A. J. Hart; C. M. Hawkes; A. T. Watson; T. Held; H. Koch; B. Lewandowski; M. Pelizaeus; K. Peters; T. Schroeder; M. Steinke; J. T. Boyd; J. P. Burke; W. N. Cottingham; D. Walker; D. J. Asgeirsson; T. Cuhadar-Donszelmann; B. G. Fulsom; C. Hearty; N. S. Knecht; T. S. Mattison; J. A. McKenna; A. Khan; P. Kyberd; M. Saleem; D. J. Sherwood; L. Teodorescu; V. E. Blinov; A. D. Bukin; V. P. Druzhinin; V. B. Golubev; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; K. Yu Todyshev; D. S. Best; M. Bondioli; M. Bruinsma; M. Chao; S. Curry; I. Eschrich; D. Kirkby; A. J. Lankford; P. Lund; M. Mandelkern; W. Roethel; D. P. Stoker; S. Abachi; C. Buchanan; S. D. Foulkes; J. W. Gary; O. Long; B. C. Shen; K. Wang; L. Zhang; H. K. Hadavand; E. J. Hill; H. P. Paar; S. Rahatlou; V. Sharma; J. W. Berryhill; C. Campagnari; A. Cunha; B. Dahmes; T. M. Hong; D. Kovalskyi; J. D. Richman; T. W. Beck; A. M. Eisner; C. J. Flacco; C. A. Heusch; J. Kroseberg; W. S. Lockman; G. Nesom; T. Schalk; B. A. Schumm; A. Seiden; P. Spradlin; D. C. Williams; M. G. Wilson; J. Albert; E. Chen; C. H. Cheng; A. Dvoretskii; F. Fang; D. G. Hitlin; I. Narsky; T. Piatenko; F. C. Porter; G. Mancinelli; B. T. Meadows; K. Mishra; M. D. Sokoloff; F. Blanc; P. C. Bloom; S. Chen; W. T. Ford; J. F. Hirschauer; A. Kreisel; M. Nagel; U. Nauenberg; A. Olivas; W. O. Ruddick; J. G. Smith; K. A. Ulmer; S. R. Wagner; J. Zhang; A. Chen; E. A. Eckhart; A. Soffer; W. H. Toki; R. J. Wilson; F. Winklmeier; Q. Zeng; D. D. Altenburg; E. Feltresi; A. Hauke; H. Jasper; J. Merkel; A. Petzold; B. Spaan; T. Brandt; V. Klose; H. M. Lacker; W. F. Mader; R. Nogowski; J. Schubert; K. R. Schubert; R. Schwierz; J. E. Sundermann; A. Volk; D. Bernard; G. R. Bonneaud; E. Latour; Ch. Thiebaux; M. Verderi; P. J. Clark; W. Gradl; F. Muheim; S. Playfer; A. I. Robertson; Y. Xie; M. Andreotti; D. Bettoni; C. Bozzi; R. Calabrese; G. Cibinetto; E. Luppi; M. Negrini; A. Petrella; L. Piemontese; E. Prencipe; F. Anulli; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; G. Finocchiaro; S. Pacetti; P. Patteri; I. M. Peruzzi; M. Piccolo; M. Rama; A. Zallo; A. Buzzo; R. Contri; M. Lo Vetere; M. M. Macri; M. R. Monge; S. Passaggio; C. Patrignani; E. Robutti; A. Santroni; S. Tosi; G. Brandenburg; K. S. Chaisanguanthum; C. L. Lee; M. Morii; J. Wu; R. S. Dubitzky; J. Marks; S. Schenk; U. Uwer; D. J. Bard; W. Bhimji; D. A. Bowerman; P. D. Dauncey; U. Egede; R. L. Flack; J. A. Nash; M. B. Nikolich; W. Panduro Vazquez; P. K. Behera; X. Chai; M. J. Charles; U. Mallik; N. T. Meyer; V. Ziegler; J. Cochran; H. B. Crawley; L. Dong; V. Eyges; W. T. Meyer; S. Prell; E. I. Rosenberg; A. E. Rubin; A. V. Gritsan; A. G. Denig; M. Fritsch; G. Schott; N. Arnaud; M. Davier; G. Grosdidier; A. Höcker; V. Lepeltier; F. Le Diberder; A. M. Lutz; A. Oyanguren; S. Pruvot; S. Rodier; P. Roudeau; M. H. Schune; J. Serrano; A. Stocchi; W. F. Wang; G. Wormser; D. J. Lange; D. M. Wright; C. A. Chavez; I. J. Forster; J. R. Fry; E. Gabathuler; R. Gamet; K. A. George; D. E. Hutchcroft; D. J. Payne; K. C. Schofield; C. Touramanis; A. J. Bevan; C. K. Clarke; F. di Lodovico; W. Menges; R. Sacco; G. Cowan; H. U. Flaecher; D. A. Hopkins; P. D. Jackson; T. R. McMahon; F. Salvatore; A. C. Wren; C. L. Davis; J. Allison; N. R. Barlow; R. J. Barlow; Y. M. Chia; C. L. Edgar; G. D. Lafferty; M. T. Naisbit; J. C. Williams; J. I. Yi; C. Chen; W. D. Hulsbergen; A. Jawahery; C. K. Lae; D. A. Roberts; G. Simi; G. Blaylock; C. Dallapiccola; S. S. Hertzbach; X. Li; T. B. Moore; S. Saremi; H. Staengle; R. Cowan; G. Sciolla; S. J. Sekula; M. Spitznagel; F. Taylor; R. K. Yamamoto; H. Kim; S. E. McLachlin; P. M. Patel; S. H. Robertson; A. Lazzaro; V. Lombardo; F. Palombo; J. M. Bauer; L. Cremaldi; V. Eschenburg; R. Godang; R. Kroeger; D. A. Sanders; D. J. Summers; H. W. Zhao; S. Brunet; D. Côté; M. Simard; P. Taras; F. B. Viaud; H. Nicholson; N. Cavallo; G. de Nardo; F. Fabozzi; C. Gatto; L. Lista; D. Monorchio; P. Paolucci; D. Piccolo; C. Sciacca; M. A. Baak; G. Raven; H. L. Snoek; C. P. Jessop; J. M. Losecco; G. Benelli; L. A. Corwin; K. K. Gan; K. Honscheid; D. Hufnagel; H. Kagan; R. Kass; A. M. Rahimi; J. J. Regensburger; R. Ter-Antonyan; Q. K. Wong; N. L. Blount; J. Brau; R. Frey; O. Igonkina; J. A. Kolb; M. Lu; C. T. Potter; R. Rahmat

    2008-01-01

    Using a data sample corresponding to an integrated luminosity of 342fb-1 collected with the BABAR detector at the SLAC PEP-II electron-positron storage ring operating at a center-of-mass energy near 10.58 GeV, we measure B(tau--->pi-pi-pi+nutau(ex.KS0))=(8.83±0.01±0.13)%, B(tau--->K-pi-pi+nutau(ex.KS0))=(0.273±0.002±0.009)%, B(tau--->K-pi-K+nutau)=(0.1346±0.0010±0.0036)%, and B(tau--->K-K-K+nutau)=(1.58±0.13±0.12)×10-5, where the uncertainties are statistical and systematic, respectively. These include significant improvements over previous measurements and a first measurement of B(tau--->K-K-K+nutau) in

  17. Ironing out Tau's Role in Parkinsonism

    PubMed Central

    Stankowski, Jeannette N.; Dawson, Valina L.; Dawson, Ted M.

    2015-01-01

    Parkinson's disease affects more than five million people worldwide, yet no therapeutic has been identified that can slow or halt the progression of this debilitating disease. A new study in tau knockout mice suggests that tau deficiency causes impaired ferroportin-coupled iron export, by retention of the amyloid precursor protein, a neuronal ferroxidase partner, in the endoplasmic reticulum. This leads to parkinsonism through intracellular iron accumulation and degeneration of dopamine neurons (pages X-Y). PMID:22310680

  18. Tau promotes neurodegeneration through global chromatin relaxation

    PubMed Central

    Frost, Bess; Hemberg, Martin; Lewis, Jada; Feany, Mel B.

    2014-01-01

    The microtubule-associated protein tau is involved in a number of neurodegenerative disorders, including Alzheimer’s disease (AD). Previous studies link oxidative stress and subsequent DNA damage to neuronal death in AD and related tauopathies. Since DNA damage can significantly alter chromatin structure, we examined epigenetic changes in tau-induced neurodegeneration. We have found widespread loss of heterochromatin in tau transgenic Drosophila and mice, and in human AD. Importantly, genetic rescue of tau-induced heterochromatin loss substantially reduced neurodegeneration in Drosophila. We identified oxidative stress and subsequent DNA damage as a mechanistic link between transgenic tau expression and heterochromatin relaxation, and found that heterochromatin loss permits aberrant gene expression in tauopathies. Furthermore, large-scale analyses from human AD brains revealed a widespread transcriptional increase in genes that are heterochromatically silenced in controls. Our results establish heterochromatin loss as a toxic effector of tau-induced neurodegeneration, and identify chromatin structure as a potential therapeutic target in AD. PMID:24464041

  19. In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

    PubMed Central

    Yamada, Kaoru; Cirrito, John R.; Stewart, Floy R.; Jiang, Hong; Finn, Mary Beth; Holmes, Brandon B.; Binder, Lester I.; Mandelkow, Eva-Maria; Diamond, Marc I.; Lee, Virginia M.-Y.; Holtzman, David M.

    2015-01-01

    Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in relation to CSF, and whether ISF tau is influenced by its aggregation are unknown. To address these issues, we developed a microdialysis technique to analyze monomeric ISF tau levels within the hippocampus of awake, freely moving mice. We detected tau in ISF of wild-type mice, suggesting that tau is released in the absence of neurodegeneration. ISF tau was significantly higher than CSF tau and their concentrations were not significantly correlated. Using P301S human tau transgenic mice (P301S tg mice), we found that ISF tau is fivefold higher than endogenous murine tau, consistent with its elevated levels of expression. However, following the onset of tau aggregation, monomeric ISF tau decreased markedly. Biochemical analysis demonstrated that soluble tau in brain homogenates decreased along with the deposition of insoluble tau. Tau fibrils injected into the hippocampus decreased ISF tau, suggesting that extracellular tau is in equilibrium with extracellular or intracellular tau aggregates. This technique should facilitate further studies of tau secretion, spread of tau pathology, the effects of different disease states on ISF tau, and the efficacy of experimental treatments. PMID:21917794

  20. Adaptive Optics Spectroscopy of Young Stellar Jets : DG Tau, HL Tau, and RW Aur

    Microsoft Academic Search

    T.-S. Pyo; M. Hayashi; N. Kobayashi; A. T. Tokunaga; H. Terada; H. Takami; N. Takato; S. S. Hayashi; T. Usuda; T. Yamashita; K. Nedachi; Y. Hayano; Y. Kamata; M. Iye; W. Gaessler

    2004-01-01

    We present results of the high angular resolution spectroscopy with the near infrared [Fe II] lambda 1.644 mu m emission line toward the outflows emanating from DG Tau, HL Tau, and RW Aur using the Adaptive Optics System of Subaru Telescope. We resolved the region within ˜140 AU (< 1'') in the vicinity of their driving sources with an angular

  1. Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.

    PubMed

    Tanemura, Kentaro; Murayama, Miyuki; Akagi, Takumi; Hashikawa, Tsutomu; Tominaga, Takashi; Ichikawa, Michinori; Yamaguchi, Haruyasu; Takashima, Akihiko

    2002-01-01

    Formation of neurofibrillary tangles (NFTs) is a common neuropathological feature found in several neurodegenerative diseases, including Alzheimer's disease. We have developed a transgenic (Tg) mouse expressing mutant human tau (V337M), derived from frontotemporal dementia parkinsonism-17. V337M Tg mice revealed tau aggregations in the hippocampus, which fulfills the histological criteria for NFTs in human neurodegenerative diseases. Concurrent with the accumulation of RNA and phosphorylated tau, neurons exhibited morphological characteristics of degenerating neurons, which include a loss of microtubules, accumulation of ribosomes, plasma and nuclear membrane ruffling, and swelling of the Golgi network. Thus, mutant tau induces neuronal degeneration associated with the accumulation of RNA and phosphorylated tau. The functional consequences of this neuronal degeneration was evidenced by the reduction of hippocampal neural activity and behavioral abnormality in Tg mice. PMID:11756496

  2. Modulation of tau protein fibrillization by oleocanthal.

    PubMed

    Monti, Maria Chiara; Margarucci, Luigi; Riccio, Raffaele; Casapullo, Agostino

    2012-09-28

    Among the phenolic compounds extracted from extra virgin olive oil, oleocanthal (1) has attracted considerable attention in the modulation of many human diseases, such as inflammation and Alzheimer's disease (AD). Indeed, 1 is capable of altering the fibrillization of tau protein, which is one of the key factors at the basis of neurodegenerative diseases, and of covalently reacting with lysine ?-amino groups of the tau fragment K18 in an unspecific fashion. In the present study, an investigation of the recognition process and the reaction profile between 1 and the wild-type tau protein has been conducted by a circular dichroism, surface plasmon resonance, fluorescence, and mass spectrometry combined approach. As a result, 1 has been found to interact with tau-441, inducing stable conformational modifications of the protein secondary structure and also interfering with tau aggregation. These findings provide experimental support for the potential reduced risk of AD and related neurodegenerative diseases associated with olive oil consumption and may offer a new chemical scaffold for the development of AD-modulating agents. PMID:22988908

  3. Studies of the VBF $H\\rightarrow\\tau_l\\tau_{had}$ analysis at High Luminosity LHC conditions

    E-print Network

    The ATLAS collaboration

    2014-01-01

    This note documents projections for the measurement of Standard Model $H\\rightarrow \\tau\\tau$ in the vector boson fusion production channel for the High Luminosity LHC (HL-LHC). The projections are based on the Run-I analysis. It is assumed that the HL-LHC will deliver an integrated luminosity of 3000 $\\text{fb}^{-1}$, a center-of-mass energy of 14 TeV and an average number of overlapping $pp$ collisions of $ = 140$. Only the VBF production is targeted, and the analysis requires one tau to decay leptonically and the other hadronically. The projected uncertainty on the signal strength is $24\\%$ when theory uncertainties are ignored and $10\\%$ ($5\\%$) background (signal) uncertainties are assumed. If the tracking coverage is extended, the projected uncertainty on the signal strength is as low as $8\\%$.

  4. Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression.

    PubMed

    Ferrer, Isidre; López-González, Irene; Carmona, Margarita; Arregui, Laura; Dalfó, Esther; Torrejón-Escribano, Benjamin; Diehl, Roberta; Kovacs, Gabor G

    2014-01-01

    Tauopathies are degenerative diseases characterized by the accumulation of phosphorylated tau in neurons and glial cells. With some exceptions, tau deposits in neurons are mainly manifested as pretangles and tangles unrelated to the tauopathy. It is thought that abnormal tau deposition in neurons occurs following specific steps, but little is known about the progression of tau pathology in glial cells in tauopathies. We compared tau pathology in different astrocyte phenotypes and oligodendroglial inclusions with that in neurons in a large series of tauopathies, including progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, Pick disease, frontotemporal lobar degenerations (FTLD) associated with mutations in the tau gene, globular glial tauopathy (GGT), and tauopathy in the elderly. Our findings indicate that disease-specific astroglial phenotypes depend on i) the primary amino acid sequence of tau (mutated tau, 3Rtau, and 4Rtau); ii) phospho-specific sites of tau phosphorylation, tau conformation, tau truncation, and ubiquitination in that order (which parallel tau modifications related to pretangle and tangle stages in neurons); and iii) modifications of the astroglial cytoskeleton. In contrast to astrocytes, coiled bodies in oligodendrocytes have similar characteristics whatever the tauopathy, except glial globular inclusions in GGT, and coiled bodies and globular oligodendroglial inclusions in FTLD-tau/K317M. These observations indicate that tau pathology in glial cells largely parallels, but is not identical to, that in neurons in many tauopathies. PMID:24335532

  5. Structural Determinants of Tau Aggregation Inhibitor Potency*

    PubMed Central

    Schafer, Kelsey N.; Cisek, Katryna; Huseby, Carol J.; Chang, Edward; Kuret, Jeff

    2013-01-01

    Small-molecule Tau aggregation inhibitors are under investigation as potential therapeutic agents against Alzheimer disease. Many such inhibitors have been identified in vitro, but their potency-driving features, and their molecular targets in the Tau aggregation pathway, have resisted identification. Previously we proposed ligand polarizability, a measure of electron delocalization, as a candidate descriptor of inhibitor potency. Here we tested this hypothesis by correlating the ground state polarizabilities of cyanine, phenothiazine, and arylmethine derivatives calculated using ab initio quantum methods with inhibitory potency values determined in the presence of octadecyl sulfate inducer under reducing conditions. A series of rhodanine analogs was analyzed as well using potency values disclosed in the literature. Results showed that polarizability and inhibitory potency directly correlated within all four series. To identify putative binding targets, representative members of the four chemotypes were added to aggregation reactions, where they were found to stabilize soluble, but SDS-resistant Tau species at the expense of filamentous aggregates. Using SDS resistance as a secondary assay, and a library of Tau deletion and missense mutants as targets, interaction with cyanine was localized to the microtubule binding repeat region. Moreover, the SDS-resistant phenotype was completely dependent on the presence of octadecyl sulfate inducer, but not intact PHF6/PH6* hexapeptide motifs, indicating that cyanine interacted with a species in the aggregation pathway prior to nucleus formation. Together the data suggest that flat, highly polarizable ligands inhibit Tau aggregation by interacting with folded species in the aggregation pathway and driving their assembly into soluble but highly stable Tau oligomers. PMID:24072703

  6. Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

    PubMed Central

    Li, Wenkai; Sperry, Jeffrey B.; Crowe, Alex; Trojanowski, John Q.; Smith, Amos B.; Lee, Virginia M.-Y.

    2009-01-01

    Tau is a microtubule-associated protein that promotes microtubule assembly and stability. In Alzheimer's disease and related tauopathies, tau fibrillizes and aggregates into neurofibrillary tangles. Recently, oleocanthal isolated from extra virgin olive oil was found to display non-steroidal anti-inflammatory activity similar to ibuprofen. Since our unpublished data indicates an inhibitory effect of oleocanthal on A? fibrillization, we reasoned that it might inhibit tau fibrillization as well. Herein we demonstrate that oleocanthal abrogates fibrillization of tau by locking tau into the naturally unfolded state. Using PHF6 consisting of the amino acid residues VQIVYK, a hexapeptide within the third repeat of tau that is essential for fibrillization, we show that oleocanthal forms an adduct with the lysine via initial Schiff base formation. Structure and function studies demonstrate that the two aldehyde groups of oleocanthal are required for the inhibitory activity. These two aldehyde groups show certain specificity when titrated with free lysine and oleocanthal does not significantly affect the normal function of tau. These findings provide a potential scheme for the development of novel therapies for neurodegenerative tauopathies. PMID:19549281

  7. Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau.

    PubMed

    Li, Wenkai; Sperry, Jeffrey B; Crowe, Alex; Trojanowski, John Q; Smith, Amos B; Lee, Virginia M-Y

    2009-08-01

    Tau is a microtubule-associated protein that promotes microtubule assembly and stability. In Alzheimer's disease and related tauopathies, tau fibrillizes and aggregates into neurofibrillary tangles. Recently, oleocanthal isolated from extra virgin olive oil was found to display non-steroidal anti-inflammatory activity similar to ibuprofen. As our unpublished data indicates an inhibitory effect of oleocanthal on amyloid beta peptide fibrillization, we reasoned that it might inhibit tau fibrillization as well. Herein, we demonstrate that oleocanthal abrogates fibrillization of tau by locking tau into the naturally unfolded state. Using PHF6 consisting of the amino acid residues VQIVYK, a hexapeptide within the third repeat of tau that is essential for fibrillization, we show that oleocanthal forms an adduct with the lysine via initial Schiff base formation. Structure and function studies demonstrate that the two aldehyde groups of oleocanthal are required for the inhibitory activity. These two aldehyde groups show certain specificity when titrated with free lysine and oleocanthal does not significantly affect the normal function of tau. These findings provide a potential scheme for the development of novel therapies for neurodegenerative tauopathies. PMID:19549281

  8. Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation*

    PubMed Central

    Crowe, Alex; James, Michael J.; Lee, Virginia M.-Y.; Smith, Amos B.; Trojanowski, John Q.; Ballatore, Carlo; Brunden, Kurt R.

    2013-01-01

    Alzheimer disease and several other neurodegenerative disorders are characterized by the accumulation of intraneuronal fibrils comprised of the protein Tau. Tau is normally a soluble protein that stabilizes microtubules, with splice isoforms that contain either three (3-R) or four (4-R) microtubule binding repeats. The formation of Tau fibrils is thought to result in neuronal damage, and inhibitors of Tau fibrillization may hold promise as therapeutic agents. The process of Tau fibrillization can be replicated in vitro, and a number of small molecules have been identified that inhibit Tau fibril formation. However, little is known about how these molecules affect Tau fibrillization. Here, we examined the mechanism by which the previously described aminothieno pyridazine (ATPZ) series of compounds inhibit Tau fibrillization. Active ATPZs were found to promote the oxidation of the two cysteine residues within 4-R Tau by a redox cycling mechanism, resulting in the formation of a disulfide-containing compact monomer that was refractory to fibrillization. Moreover, the ATPZs facilitated intermolecular disulfide formation between 3-R Tau monomers, leading to dimers that were capable of fibrillization. The ATPZs also caused cysteine oxidation in molecules unrelated to Tau. Interestingly, methylene blue, an inhibitor of Tau fibrillization under evaluation in Alzheimer disease clinical trials, caused a similar oxidation of cysteines in Tau and other molecules. These findings reveal that the ATPZs and methylene blue act by a mechanism that may affect their viability as potential therapeutic agents. PMID:23443659

  9. Tau phosphorylation and tau mislocalization mediate soluble A? oligomer-induced AMPA glutamate receptor signaling deficits

    PubMed Central

    Miller, Eric C.; Teravskis, Peter J.; Dummer, Benjamin W.; Zhao, Xiaohui; Huganir, Richard L.; Liao, Dezhi

    2014-01-01

    In our previous studies, phosphorylation-dependent tau mislocalization to dendritic spines resulted in early cognitive and synaptic deficits. It is well known that amyloid beta (A?) oligomers cause synaptic dysfunction by inducing calcineurin-dependent AMPA receptor (AMPAR) internalization. However, it is unknown whether A?-induced synaptic deficits depend upon tau phosphorylation. It is also unknown whether changes in tau can cause calcineurin-dependent loss of AMPARs in synapses. Here, we show that tau mislocalizes to dendritic spines in cultured hippocampal neurons from APPSwe Alzheimer’s disease (AD)-transgenenic mice and in cultured rat hippocampal neurons treated with soluble A? oligomers. Interestingly, A? treatment also impairs synaptic function by decreasing the amplitude of miniature excitatory postsynaptic currents (mEPSCs). The above tau mislocalization and A?-induced synaptic impairment are both diminished by the expression of AP tau, indicating that these events require tau phosphorylation. The phosphatase activity of calcineurin is important for AMPAR internalization via dephosphorylation of GluA1 residue S845. The effects of A? oligomers on mEPSCs are blocked by the calcineurin inhibitor FK506. A?-induced loss of AMPARs is diminished in neurons from knock-in mice expressing S845A mutant GluA1 AMPA glutamate receptor subunits. This finding suggests that changes in phosphorylation state at S845 are involved in this pathogenic cascade. Furthermore, FK506 rescues deficits in surface AMPAR clustering on dendritic spines in neurons cultured from transgenic mice expressing P301L tau proteins. Together, our results support the role of tau and calcineurin as two intermediate signaling molecules between A? initiation and eventual synaptic dysfunction early in AD pathogenesis. PMID:24713000

  10. Upper Limit on the Diffuse Flux of Ultrahigh Energy Tau Neutrinos from the Pierre Auger Observatory

    Microsoft Academic Search

    J. Abraham; P. Abreu; M. Aglietta; C. Aguirre; D. Allard; I. Allekotte; J. Allen; P. Allison; J. Alvarez-Muñiz; M. Ambrosio; L. Anchordoqui; S. Andringa; A. Anzalone; C. Aramo; S. Argirò; K. Arisaka; E. Armengaud; F. Arneodo; F. Arqueros; T. Asch; H. Asorey; P. Assis; B. S. Atulugama; J. Aublin; G. Avila; T. Bäcker; D. Badagnani; A. F. Barbosa; D. Barnhill; S. L. C. Barroso; P. Bauleo; J. J. Beatty; T. Beau; B. R. Becker; K. H. Becker; J. A. Bellido; S. Benzvi; C. Berat; T. Bergmann; P. Bernardini; X. Bertou; P. L. Biermann; P. Billoir; O. Blanch-Bigas; F. Blanco; P. Blasi; H. Blümer; M. Bohácová; C. Bonifazi; R. Bonino; M. Boratav; J. Brack; P. Brogueira; W. C. Brown; P. Buchholz; A. Bueno; R. E. Burton; N. G. Busca; K. S. Caballero-Mora; B. Cai; D. V. Camin; L. Caramete; R. Caruso; W. Carvalho; A. Castellina; O. Catalano; G. Cataldi; L. Cazon; R. Cester; J. A. Chinellato; A. Chiavassa; A. Chou; J. Chye; P. D. J. Clark; R. W. Clay; E. Colombo; R. Conceição; B. Connolly; F. Contreras; J. Coppens; A. Cordier; U. Cotti; S. Coutu; C. E. Covault; A. Creusot; A. Criss; J. Cronin; A. Curutiu; S. Dagoret-Campagne; K. Daumiller; B. R. Dawson; R. M. de Almeida; C. de Donato; S. J. de Jong; G. de La Vega; W. J. M. de Mello Junior; I. Demitri; V. de Souza; L. Del Peral; O. Deligny; A. Della Selva; C. Delle Fratte; H. Dembinski; C. di Giulio; J. C. Diaz; C. Dobrigkeit; J. C. D'Olivo; D. Dornic; A. Dorofeev; J. C. Dos Anjos; M. T. Dova; D. D'Urso; I. Dutan; M. A. Duvernois; R. Engel; L. Epele; M. Erdmann; C. O. Escobar; A. Etchegoyen; P. Facal San Luis; H. Falcke; G. Farrar; A. C. Fauth; N. Fazzini; F. Ferrer; S. Ferry; B. Fick; A. Filevich; A. Filipcic; I. Fleck; R. Fonte; C. E. Fracchiolla; W. Fulgione; B. García; D. García Gámez; D. Garcia-Pinto; X. Garrido; H. Geenen; G. Gelmini; H. Gemmeke; P. L. Ghia; M. Giller; H. Glass; M. S. Gold; G. Golup; F. Gomez Albarracin; M. Gómez Berisso; R. Gómez Herrero; P. Gonçalves; M. Gonçalves Do Amaral; D. Gonzalez; J. G. Gonzalez; M. González; D. Góra; A. Gorgi; P. Gouffon; V. Grassi; A. F. Grillo; C. Grunfeld; Y. Guardincerri; F. Guarino; G. P. Guedes; J. Gutiérrez; J. D. Hague; J. C. Hamilton; P. Hansen; D. Harari; S. Harmsma; J. L. Harton; A. Haungs; T. Hauschildt; M. D. Healy; T. Hebbeker; G. Hebrero; D. Heck; C. Hojvat; V. C. Holmes; P. Homola; J. Hörandel; A. Horneffer; M. Horvat; M. Hrabovský; T. Huege; M. Hussain; M. Iarlori; A. Insolia; F. Ionita; A. Italiano; M. Kaducak; K. H. Kampert; T. Karova; B. Kégl; B. Keilhauer; E. Kemp; R. M. Kieckhafer; H. O. Klages; M. Kleifges; J. Kleinfeller; R. Knapik; J. Knapp; D.-H. Koang; A. Krieger; O. Krömer; D. Kuempel; N. Kunka; A. Kusenko; G. La Rosa; C. Lachaud; B. L. Lago; D. Lebrun; P. Lebrun; J. Lee; M. A. Leigui de Oliveira; A. Letessier-Selvon; M. Leuthold; I. Lhenry-Yvon; R. López; A. Lopez Agüera; J. Lozano Bahilo; R. Luna García; M. C. Maccarone; C. Macolino; S. Maldera; G. Mancarella; M. E. Manceñido; D. Mandat; P. Mantsch; A. G. Mariazzi; I. C. Maris; H. R. Marquez Falcon; D. Martello; J. Martínez; O. Martínez Bravo; H. J. Mathes; J. Matthews; G. Matthiae; D. Maurizio; P. O. Mazur; T. McCauley; M. McEwen; R. R. McNeil; M. C. Medina; G. Medina-Tanco; A. Meli; D. Melo; E. Menichetti; A. Menschikov; Chr. Meurer; R. Meyhandan; M. I. Micheletti; G. Miele; W. Miller; S. Mollerach; M. Monasor; D. Monnier Ragaigne; F. Montanet; B. Morales; C. Morello; J. C. Moreno; C. Morris; M. Mostafá; M. A. Muller; R. Mussa; G. Navarra; J. L. Navarro; S. Navas; P. Necesal; L. Nellen; C. Newman-Holmes; D. Newton; T. Nguyen Thi; N. Nierstenhoefer; D. Nitz; D. Nosek; L. Nozka; J. Oehlschläger; T. Ohnuki; A. Olinto; V. M. Olmos-Gilbaja; M. Ortiz; F. Ortolani; S. Ostapchenko; L. Otero; N. Pacheco; D. Pakk Selmi-Dei; M. Palatka; J. Pallotta; G. Parente; E. Parizot; S. Parlati; S. Pastor; M. Patel; T. Paul; V. Pavlidou; K. Payet; M. Pech; J. Pekala; R. Pelayo; I. M. Pepe; L. Perrone; S. Petrera; P. Petrinca; Y. Petrov; Diep Pham Ngoc; Dong Pham Ngoc; T. N. Pham Thi; A. Pichel; R. Piegaia; T. Pierog; M. Pimenta; T. Pinto; V. Pirronello; O. Pisanti; M. Platino; J. Pochon; P. Privitera; M. Prouza; E. J. Quel; J. Rautenberg; A. Redondo; S. Reucroft; B. Revenu; F. A. S. Rezende; J. Ridky; S. Riggi; M. Risse; C. Rivière; V. Rizi; M. Roberts; C. Robledo; G. Rodriguez; D. Rodríguez Frías; J. Rodriguez Martino; J. Rodriguez Rojo; I. Rodriguez-Cabo; G. Ros; J. Rosado; M. Roth; B. Rouillé-D'Orfeuil; E. Roulet; A. C. Rovero; F. Salamida; H. Salazar; G. Salina; F. Sánchez; M. Santander; C. E. Santo; E. M. Santos; F. Sarazin; S. Sarkar; R. Sato; V. Scherini; H. Schieler; A. Schmidt; F. Schmidt; T. Schmidt; O. Scholten; P. Schovánek; F. Schüssler; S. J. Sciutto; M. Scuderi; A. Segreto; D. Semikoz; M. Settimo; R. C. Shellard; I. Sidelnik; B. B. Siffert; G. Sigl

    2008-01-01

    The surface detector array of the Pierre Auger Observatory is sensitive to Earth-skimming tau neutrinos that interact in Earth's crust. Tau leptons from nutau charged-current interactions can emerge and decay in the atmosphere to produce a nearly horizontal shower with a significant electromagnetic component. The data collected between 1 January 2004 and 31 August 2007 are used to place an

  11. The first observation of $\\tau^{\\pm} \\to \\phi K^{\\pm} \

    E-print Network

    Abe, K; Aihara, H; Anipko, D; Aoki, K; Arakawa, T; Arinstein, K; Asano, Y; Aso, T; Aulchenko, V M; Aushev, T; Aziz, T; Bahinipati, S; Bakich, A M; Balagura, V; Ban, Y; Banerjee, S; Barberio, E; Barbero, M; Bay, A; Bedny, I; Belous, K S; Bitenc, U; Bizjak, I; Blyth, S; Bondar, A; Bozek, A; Bracko, M; Brodzicka, J; Browder, T E; Chang, M C; Chang, P; Chao, Y; Chen, A; Chen, K F; Chen, W T; Cheon, B G; Chistov, R; Choi, J H; Choi, S K; Choi, Y; Choi, Y K; Chuvikov, A; Cole, S; Dalseno, J; Danilov, M; Dash, M; Dowd, R; Dragic, J; Drutskoy, A; Eidelman, S; Enari, Y; Epifanov, D A; Fratina, S; Fujii, H; Fujikawa, M; Gabyshev, N; Garmash, A; Gershon, T; Go, A; Gokhroo, G; Goldenzweig, P; Golob, B; Gorisek, A; Grosse-Perdekamp, M; Guler, H; Ha, H; Haba, J; Hara, K; Hara, T; Hasegawa, Y; Hastings, N C; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Higuchi, T; Hinz, L; Hokuue, T; Hoshi, Y; Hoshina, K; Hou, S; Hou, W S; Hsiung, Y B; Igarashi, Y; Iijima, T; Ikado, K; Imoto, A; Inami, K; Ishikawa, A; Ishino, H; Itoh, K; Itoh, R; Iwabuchi, M; Iwasaki, M; Iwasaki, Y; Jacoby, C; Jones, M; Kakuno, H; Kang, J H; Kang, J S; Kapusta, P; Kataoka, S U; Katayama, N; Kawai, H; Kawasaki, T; Khan, H R; Kibayashi, A; Kichimi, H; Kikuchi, N; Kim, H J; Kim, H O; Kim, J H; Kim, S K; Kim, T H; Kim, Y J; Kinoshita, K; Kishimoto, N; Korpar, S; Kozakai, Y; Krizan, P; Krokovnyi, P P; Kubota, T; Kulasiri, R; Kumar, R; Kuo, C C; Kurihara, E; Kusaka, A; Kuzmin, A; Kwon, Y J; Lange, J S; Leder, G; Lee, J; Lee, S E; Lee, Y J; Lesiak, T; Li, J; Limosani, A; Lin, C Y; Lin, S W; Liu, Y; Liventsev, D; MacNaughton, J; Majumder, G; Mandl, F; Marlow, D; Matsumoto, T; Matyja, A; McOnie, S; Medvedeva, T; Mikami, Y; Mitaroff, W A; Miyabayashi, K; Miyake, H; Miyata, H; Miyazaki, Y; Mizuk, R; Mohapatra, D; Moloney, G R; Mori, T; Müller, J; Murakami, A; Nagamine, T; Nagasaka, Y; Nakagawa, T; Nakahama, Y; Nakamura, I; Nakano, E; Nakao, M; Nakazawa, H; Natkaniec, Z; Neichi, K; Nishida, S; Nishimura, K; Nitoh, O; Noguchi, S; Nozaki, T; Ogawa, A; Ogawa, S; Ohshima, T; Okabe, T; Okuno, S; Olsen, S L; Ono, S; Ostrowicz, W; Ozaki, H; Pakhlov, P; Pakhlova, G; Palka, H; Park, C W; Park, H; Park, K S; Parslow, N; Peak, L S; Pernicka, M; Pestotnik, R; Peters, M; Piilonen, L E; Poluektov, A; Ronga, F J; Root, N; Rorie, J; Rózanska, M; Sahoo, H; Saitoh, S; Sakai, Y; Sakamoto, H; Sakaue, H; Sarangi, T R; Sato, N; Satoyama, N; Sayeed, K; Schietinger, T; Schneider, O; Schonmeier, P; Schümann, J; Schwanda, C; Schwartz, A J; Seidl, R; Seki, T; Senyo, K; Sevior, M E; Shapkin, M; Shen, Y T; Shibuya, H; Shwartz, B; Sidorov, V; Singh, J B; Sokolov, A; Somov, A; Soni, N; Stamen, R; Stanic, S; Staric, M; Stöck, H; Sugiyama, A; Sumisawa, K; Sumiyoshi, T; Suzuki, S; Suzuki, S Y; Tajima, O; Takada, N; Takasaki, F; Tamai, K; Tamura, N; Tanabe, K; Tanaka, M; Taylor, G N; Teramoto, Y; Tian, X C; Tikhomirov, I; Trabelsi, K; Tsai, Y T; Tse, Y F; Tsuboyama, T; Tsukamoto, T; Uchida, K; Uchida, Y; Uehara, S; Uglov, T; Ueno, K; Unno, Y; Uno, S; Urquijo, P; Ushiroda, Y; Usov, Yu; Varner, G; Varvell, K E; Villa, S; Wang, C C; Wang, C H; Wang, M Z; Watanabe, M; Watanabe, Y; Wicht, J; Widhalm, L; Wiechczynski, J; Won, E; Wu, C H; Xie, Q L; Yabsley, B D; Yamaguchi, A; Yamamoto, H; Yamamoto, S; Yamashita, Y; Yamauchi, M; Heyoung Yang; Yoshino, S; Yuan, Y; Yusa, Y; Zang, S L; Zhang, C C; Zhang, J; Zhang, L M; Zhang, Z P; Zhilich, V; Ziegler, T; Zupanc, A; Zürcher, D

    2006-01-01

    We present the first measurement of tau-decays to hadronic final states with a $\\phi$-meson. This is based on 401.4 fb$^{-1}$ of data accumulated at the Belle experiment. The branching ratio obtained is $B(\\tau^{\\pm}\\to\\phi K^{\\pm}\

  12. A Search for supersymmetric Higgs bosons in the di-tau decay mode in p anti-p collisions at s**(1/2) = 1.8-TeV

    SciTech Connect

    Acosta, D.; Affolder, Anthony A.; Albrow, M.G.; Ambrose, D.; Amidei, D.; Anikeev, K.; Antos, J.; Apollinari, G.; Arisawa, T.; Artikov, A.; Ashmanskas, W.; Azfar, F.; Azzi-Bacchetta, P.; Bacchetta, N.; Bachacou, H.; Badgett, W.; Barbaro-Galtieri, A.; Barnes, V.E.; Barnett, B.A.; Baroiant, S.; Barone, M.; /Taiwan, Inst. Phys. /Argonne, PHY /INFN,

    2005-06-01

    A search for direct production of Higgs bosons in the di-tau decay mode is performed with 86.3 {+-} 3.5 pb{sup -1} of data collected with the Collider Detector at Fermilab during the 1994-1995 data taking period of the Tevatron. We search for events where one tau decays to an electron plus neutrinos and the other tau decays hadronically. We perform a counting experiment and set limits on the cross section for supersymmetric Higgs boson production where tan {beta} is large and m{sub A} is small. For a benchmark parameter space point where m{sub A{sup 0}} = 100 GeV/c{sup 2} and tan {beta} = 50, we limit the production cross section multiplied by the branching ratio to be less than 77.9 pb at the 95% confidence level compared to theoretically predicted value of 11.0 pb. This is the first search for Higgs bosons decaying to tau pairs at a hadron collider.

  13. Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.

    PubMed

    Calafate, Sara; Buist, Arjan; Miskiewicz, Katarzyna; Vijayan, Vinoy; Daneels, Guy; de Strooper, Bart; de Wit, Joris; Verstreken, Patrik; Moechars, Diederik

    2015-05-26

    Accumulation of insoluble Tau protein aggregates and stereotypical propagation of Tau pathology through the brain are common hallmarks of tauopathies, including Alzheimer's disease (AD). Propagation of Tau pathology appears to occur along connected neurons, but whether synaptic contacts between neurons are facilitating propagation has not been demonstrated. Using quantitative in vitro models, we demonstrate that, in parallel to non-synaptic mechanisms, synapses, but not merely the close distance between the cells, enhance the propagation of Tau pathology between acceptor hippocampal neurons and Tau donor cells. Similarly, in an artificial neuronal network using microfluidic devices, synapses and synaptic activity are promoting neuronal Tau pathology propagation in parallel to the non-synaptic mechanisms. Our work indicates that the physical presence of synaptic contacts between neurons facilitate Tau pathology propagation. These findings can have implications for synaptic repair therapies, which may turn out to have adverse effects by promoting propagation of Tau pathology. PMID:25981034

  14. Tau physics at p{bar p} colliders

    SciTech Connect

    Konigsberg, J. [Harvard Univ., Cambridge, MA (United States). High Energy Physics Lab.

    1993-01-01

    Tau detection techniques in hadron colliders are discussed together with the measurements and searches performed so far. We also underline the importance tau physics has in present and future collider experiments.

  15. Tau physics at p[bar p] colliders

    SciTech Connect

    Konigsberg, J. (Harvard Univ., Cambridge, MA (United States). High Energy Physics Lab.)

    1993-01-01

    Tau detection techniques in hadron colliders are discussed together with the measurements and searches performed so far. We also underline the importance tau physics has in present and future collider experiments.

  16. Multinomial tau-leaping method for stochastic kinetic simulations

    Microsoft Academic Search

    Michel F. Pettigrew; Haluk Resat

    2007-01-01

    We introduce the multinomial tau-leaping (MtauL) method for general reaction networks with multichannel reactant dependencies. The MtauL method is an extension of the binomial tau-leaping method where efficiency is improved in several ways. First, tau-leaping steps are determined simply and efficiently using a priori information and Poisson distribution-based estimates of expectation values for reaction numbers over a tentative tau-leaping step.

  17. A precision measurement of the Z{sup 0} lineshape parameters for the process Z{sup 0} {r_arrow} {tau}{sup +}{tau}{sup {minus}}

    SciTech Connect

    Lahmann, R.

    1996-12-31

    In this dissertation, a measurement of the partial decay width of the process Z{sup 0} {r_arrow} {tau}{sup +}{tau}{sup {minus}} using data collected during 1993 and 1994 at the OPAL detector at CERN is described. The cross sections of this process at three center-of-mass energies near the Z{sup 0} resonance were determined, and from a fit to those cross sections, the mass of the Z{sup 0}, its total decay width and its partial decay width into {tau}{sup +}{tau}{sup {minus}} final states were determined as M{sub Z} = 91.183 {+-} 0.020 GeV, {Lambda}{sub tot} = 2.514 {+-} 0.018 GeV and {Lambda}{sub {tau}{tau}} = 84.54 {+-} 0.59 MeV. Using published results for M{sub Z}, and {Lambda}{sub tot} with higher accuracy, a value for the partial decay width of {Lambda}{sub {tau}{tau}} = 84.02 {+-} 0.20 MeV was obtained. Further using published results for the decay width of the Z{sup 0} into quark pair final states, the invisible decay width of the Z{sup 0} was determined as {Lambda}{sub inv} = 496.9 {+-} 4.1 MeV, and the number of neutrino generations was determined as N{sub {nu}} = 2.974 {+-} 0.025(exp) {+-} 0.007 (m{sub top}, M{sub Higgs}). All results were found to be in good agreement with the Standard Model predictions and were consistent with the assumption of lepton universality within the Standard Model framework.

  18. in mice expressing mutant (P301L) tau protein

    Microsoft Academic Search

    Jada Lewis; Eileen McGowan; Julia Rockwood; Heather Melrose; Parimala Nacharaju; Marjon Van Slegtenhorst; Katrina Gwinn-Hardy; M. Paul Murphy; Matt Baker; Xin Yu; Karen Duff; John Hardy; Anthony Corral; Wen-Lang Lin; Shu-Hui Yen; Dennis W. Dickson; Peter Davies; Mike Hutton

    Neurofibrillary tangles (NFT) composed of the microtubule-associ- ated protein tau are prominent in Alzheimer disease (AD), Pick disease, progressive supranuclear palsy (PSP) and corticobasal degeneration1 (CBD). Mutations in the gene (Mtapt) encoding tau protein cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), thereby proving that tau dysfunc- tion can directly result in neurodegeneration 2 . Expression of human

  19. Registration required er.tau2013@gmail.com

    E-print Network

    Shamir, Ron

    Registration required er.tau2013@gmail.com Lisa F. Barrett Joan Y. Chiao Philippe R. Goldin James J of Affect and Regulation in Humans Keynote Lectures:K #12;Registration required er.tau2013@gmail and affiliation to er.tau2013@gmail.com Call for Abstracts The deadline to submit abstracts for poster

  20. Resolved Multifrequency Radio Observations of GG Tau

    NASA Astrophysics Data System (ADS)

    Andrews, Sean M.; Chandler, Claire J.; Isella, Andrea; Birnstiel, T.; Rosenfeld, K. A.; Wilner, D. J.; Pérez, L. M.; Ricci, L.; Carpenter, J. M.; Calvet, N.; Corder, S. A.; Deller, A. T.; Dullemond, C. P.; Greaves, J. S.; Harris, R. J.; Henning, Th.; Kwon, W.; Lazio, J.; Linz, H.; Mundy, L. G.; Sargent, A. I.; Storm, S.; Testi, L.

    2014-06-01

    We present subarcsecond resolution observations of continuum emission associated with the GG Tau quadruple star system at wavelengths of 1.3, 2.8, 7.3, and 50 mm. These data confirm that the GG Tau A binary is encircled by a circumbinary ring at a radius of 235 AU with a FWHM width of ~60 AU. We find no clear evidence for a radial gradient in the spectral shape of the ring, suggesting that the particle size distribution is spatially homogeneous on angular scales gsim0.''1. A central point source, likely associated with the primary component (GG Tau Aa), exhibits a composite spectrum from dust and free-free emission. Faint emission at 7.3 mm is observed toward the low-mass star GG Tau Ba, although its origin remains uncertain. Using these measurements of the resolved, multifrequency emission structure of the GG Tau A system, models of the far-infrared to radio spectrum are developed to place constraints on the grain size distribution and dust mass in the circumbinary ring. The non-negligible curvature present in the ring spectrum implies a maximum particle size of 1-10 mm, although we are unable to place strong constraints on the distribution shape. The corresponding dust mass is 30-300 M ?, at a temperature of 20-30 K. We discuss how this significant concentration of relatively large particles in a narrow ring at a large radius might be produced in a local region of higher gas pressures (i.e., a particle "trap") located near the inner edge of the circumbinary disk.

  1. Resolved Multifrequency Radio Observations of GG Tau

    NASA Astrophysics Data System (ADS)

    Andrews, Sean M.; Chandler, Claire J.; Isella, Andrea; Birnstiel, Tilman; Rosenfeld, Katharine; Wilner, David J.; Perez, Laura M.; Ricci, Luca; Carpenter, John M.

    2014-06-01

    We present sub-arcsecond resolution observations of continuum emission associated with the GG Tau quadruple star system at wavelengths of 1.3, 2.8, 7.3, and 50 mm. These data confirm that the GG Tau A binary is encircled by a narrow (FWHM of 60 AU) circumbinary ring centered at a radius of 235 AU. We find no evidence for a radial gradient in the ring spectrum, suggesting that the particle size distribution is spatially homogeneous. A central point source, likely associated with the primary component (GG Tau Aa), exhibits a composite spectrum from dust and free-free emission. Faint emission at 7.3 mm is observed toward the low-mass star GG Tau Ba, although its origin remains uncertain. Using these measurements of the resolved, multifrequency emission structure of the GG Tau A system, models of the far-infrared to radio spectrum are developed to place constraints on the grain size distribution and dust mass in the circumbinary ring. The non-negligible curvature present in the ring spectrum implies a maximum particle size of 1-10 mm, although we are unable to place strong constraints on the distribution shape. The corresponding dust mass is 30-300 earth masses, at a temperature of 20--30 K. We show how this significant concentration of relatively large particles in a narrow ring at a large radius might be produced in a local region of higher gas pressures (i.e., a particle "trap") located near the inner edge of the circumbinary disk.

  2. A Measurement of the charged-current interaction cross section of the tau neutrino

    SciTech Connect

    Maher, Emily O'Connor; /Minnesota U.

    2005-01-01

    The Fermilab experiment E872 (DONUT) was designed to make the first observation of the tau neutrino charged-current interaction. Using a hybrid emulsion-spectrometer detector, the tau lepton was identified by its single-prong or trident decay. Six interactions were observed, of which five were in the deep inelastic scattering region. These five interaction were used to measure the charged-current cross section of the tau neutrino. To minimize uncertainties, the tau neutrino cross section was measured relative to the electron neutrino cross section. The result {sigma}{sub {nu}{sub {tau}}N}{sup const}/{sigma}{sub {nu}{sub e}N}{sup const} = 0.77 {+-} 0.39 is consistent with 1.0, which is predicted by lepton universality. The tau neutrino cross section was also measured for 115 GeV neutrinos, which was the average energy of the interacted tau neutrinos. The result {sigma}{sub {nu}{sub {tau}}N}{sup exp} = 45 {+-} 21 x 10{sup -38} cm{sup 2} is consistent with the standard model prediction calculated in this thesis, {sigma}{sub {tau}N}{sup SM} = 48 {+-} 5 x 10{sup -38} cm{sup 2}.

  3. Locations and immunoreactivities of phosphorylation sites on bovine and porcine tau proteins and a PHF-tau fragment.

    PubMed

    Poulter, L; Barratt, D; Scott, C W; Caputo, C B

    1993-05-01

    Tau protein is a phosphorylated neuronal microtubule-associated protein. Tau protein is also present in the major pathological lesions of Alzheimer's disease in an insoluble hyperphosphorylated state as paired helical filaments (PHFs). We have investigated the phosphorylation state of control taus and a fragment of PHF-tau. Tau samples were digested with protease, separated by reversed-phase high-performance liquid chromatography, and analyzed by mass spectrometry and Edman microsequencing. The serine homologous with S404 of human tau 441 was phosphorylated on bovine and porcine tau and up to two phosphates were present on a peptide of amino acids 182-240 of bovine tau (193-251 of human tau 441). The serine within the KSPV motif was not phosphorylated on bovine or porcine tau. PHF-tau fragments, isolated from pronase-treated PHFs encompassed a 93-amino acid region within the microtubule binding domain. Enzymatic digestion and mass spectrometric analysis showed no phosphate was present and a second carboxyl terminus was identified at E380. Antibodies T3P and SMI34, which recognize PHF-tau and peptides phosphorylated at the sequence KSPV, both reacted with bovine and porcine tau even though the KSPV sequence was not phosphorylated. These data indicate that the 93-amino acid sequence of F5.5 tau from PHFs is not phosphorylated, and the serine equivalent to S404 of human tau is phosphorylated in bovine and porcine tau. Antibodies T3P and SMI34 react with phosphorylated epitopes that are not unique to PHF-tau and that are not necessarily at the KSPV site. PMID:8486651

  4. Physics with Tau-Lepton Final States in ATLAS

    E-print Network

    Ruthmann, N; The ATLAS collaboration

    2012-01-01

    Heading into its third year of data-taking ATLAS already published a large number of measurements and searches for processes with $\\tau$ leptons in the final state. In this note a broad overview over the ATLAS physics programme involving $\\tau$-leptons will be given. Searches for a SM Higgs boson, charged Higgs bosons as proposed in supersymmetric models and searches for supersymmetry in events with tau leptons are presented as well as Standard Model measurements. The first measurement of the $\\tau$ polarization in $W\\rightarrow\\tau\

  5. The Disk around the Brown Dwarf KPNO Tau 3

    NASA Astrophysics Data System (ADS)

    Broekhoven-Fiene, Hannah; Matthews, Brenda; Duchêne, Gaspard; Di Francesco, James; Scholz, Aleks; Chrysostomou, Antonio; Jayawardhana, Ray

    2014-07-01

    We present submillimeter observations of the young brown dwarfs KPNO Tau 1, KPNO Tau 3, and KPNO Tau 6 at 450 ?m and 850 ?m taken with the Submillimetre Common-User Bolometer Array on the James Clerk Maxwell Telescope. KPNO Tau 3 and KPNO Tau 6 have been previously identified as Class II objects hosting accretion disks, whereas KPNO Tau 1 has been identified as a Class III object and shows no evidence of circumsubstellar material. Our 3? detection of cold dust around KPNO Tau 3 implies a total disk mass of (4.0 ± 1.1) × 10-4 M ? (assuming a gas to dust ratio of 100:1). We place tight constraints on any disks around KPNO Tau 1 or KPNO Tau 6 of <2.1 × 10-4 M ? and <2.7 × 10-4 M ?, respectively. Modeling the spectral energy distribution of KPNO Tau 3 and its disk suggests the disk properties (geometry, dust mass, and grain size distribution) are consistent with observations of other brown dwarf disks and low-mass T-Tauri stars. In particular, the disk-to-host mass ratio for KPNO Tau 3 is congruent with the scenario that at least some brown dwarfs form via the same mechanism as low-mass stars.

  6. APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

    PubMed Central

    Moore, Steven; Evans, Lewis D.B.; Andersson, Therese; Portelius, Erik; Smith, James; Dias, Tatyana B.; Saurat, Nathalie; McGlade, Amelia; Kirwan, Peter; Blennow, Kaj; Hardy, John; Zetterberg, Henrik; Livesey, Frederick J.

    2015-01-01

    Summary Accumulation of A? peptide fragments of the APP protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of Alzheimer’s disease (AD). To investigate the relationship between APP metabolism and tau protein levels and phosphorylation, we studied human-stem-cell-derived forebrain neurons with genetic forms of AD, all of which increase the release of pathogenic A? peptides. We identified marked increases in intracellular tau in genetic forms of AD that either mutated APP or increased its dosage, suggesting that APP metabolism is coupled to changes in tau proteostasis. Manipulating APP metabolism by ?-secretase and ?-secretase inhibition, as well as ?-secretase modulation, results in specific increases and decreases in tau protein levels. These data demonstrate that APP metabolism regulates tau proteostasis and suggest that the relationship between APP processing and tau is not mediated solely through extracellular A? signaling to neurons. PMID:25921538

  7. PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo

    PubMed Central

    Okuda, Michiaki; Hijikuro, Ichiro; Fujita, Yuki; Wu, Xiaofeng; Nakayama, Shinichi; Sakata, Yoko; Noguchi, Yuji; Ogo, Makoto; Akasofu, Shigeru; Ito, Yoshimasa; Soeda, Yoshiyuki; Tsuchiya, Nobuhiko; Tanaka, Naoki; Takahashi, Takashi; Sugimoto, Hachiro

    2015-01-01

    In tauopathies, a neural microtubule-associated protein tau (MAPT) is abnormally aggregated and forms neurofibrillary tangle. Therefore, inhibition of the tau aggregation is one of the key approaches for the treatment of these diseases. Here, we have identified a novel tau aggregation inhibitor, PE859. An oral administration of PE859 resulted in the significant reduction of sarkosyl-insoluble aggregated tau along with the prevention of onset and progression of the motor dysfunction in JNPL3 P301L-mutated human tau transgenic mice. These results suggest that PE859 is useful for the treatment of tauopathies. PMID:25659102

  8. PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo.

    PubMed

    Okuda, Michiaki; Hijikuro, Ichiro; Fujita, Yuki; Wu, Xiaofeng; Nakayama, Shinichi; Sakata, Yoko; Noguchi, Yuji; Ogo, Makoto; Akasofu, Shigeru; Ito, Yoshimasa; Soeda, Yoshiyuki; Tsuchiya, Nobuhiko; Tanaka, Naoki; Takahashi, Takashi; Sugimoto, Hachiro

    2015-01-01

    In tauopathies, a neural microtubule-associated protein tau (MAPT) is abnormally aggregated and forms neurofibrillary tangle. Therefore, inhibition of the tau aggregation is one of the key approaches for the treatment of these diseases. Here, we have identified a novel tau aggregation inhibitor, PE859. An oral administration of PE859 resulted in the significant reduction of sarkosyl-insoluble aggregated tau along with the prevention of onset and progression of the motor dysfunction in JNPL3 P301L-mutated human tau transgenic mice. These results suggest that PE859 is useful for the treatment of tauopathies. PMID:25659102

  9. The Copernicus ultraviolet spectral atlas Tau Scorpii

    NASA Technical Reports Server (NTRS)

    Rogerson, J. B., Jr.; Upson, W. L., II

    1977-01-01

    An ultraviolet spectral atlas was presented for the B0 V star, Tau Scorpii. It was scanned from 949 to 1560 A by the Princeton spectrometer aboard the Copernicus satellite. From 949 to 1420 A the observations have a nominal resolution of 0.05 A. At the longer wavelengths, the resolution was 0.1 A. The atlas was presented in both tables and graphs.

  10. V409 Tau as Another AA Tau: Photometric Observations of Stellar Occultations by the Circumstellar Disk

    NASA Astrophysics Data System (ADS)

    Rodriguez, Joseph E.; Pepper, Joshua; Stassun, Keivan G.; Siverd, Robert J.; Cargile, Phillip; Weintraub, David A.; Beatty, Thomas G.; Gaudi, B. Scott; Mamajek, Eric E.; Sanchez, N. Nicole

    2015-07-01

    AA Tau is a well studied young stellar object (YSO) that presents many of the photometric characteristics of a Classical T Tauri star (CTTS), including short-timescale stochastic variability attributed to spots and/or accretion as well as long-duration dimming events attributed to occultations by vertical features (e.g., warps) in its circumstellar disk. We present new photometric observations of AA Tau from the Kilodegree Extremely Little Telescope North (KELT-North) which reveal a deep, extended dimming event in 2011, which we show supports the interpretation by Bouvier et al. of an occultation by a high-density feature in the circumstellar disk located \\gt 8 AU from the star. We also present KELT-North observations of V409 Tau, a relatively unstudied YSO also in Taurus–Auriga, showing short timescale erratic variability, along with two separate long and deep dimming events, one from 2009 January through late 2010 October, and the other from 2012 March until at least 2013 September. We interpret both dimming events to have lasted more than 600 days, each with a depth of ?1.4 mag. From a spectral energy distribution analysis, we propose that V409 Tau is most likely surrounded by a circumstellar disk viewed nearly edge-on, and using Keplerian timescale arguments we interpret the deep dimmings of V409 Tau as occultations from one or more features within this disk ?10 AU from the star. In both AA Tau and V409 Tau, the usual CTTS short-timescale variations associated with accretion processes close to the stars continue during the occultations, further supporting the distant occulting material interpretation. Like AA Tau, V409 Tau serves as a laboratory for studying the detailed structure of the protoplanetary environments of T Tauri disks, specifically disk structures that may be signposts of planet formation at many AU out in the disk. We also provide a table of all currently known disk-occulting young stars as a convenient reference for future work on such objects.

  11. Upper limit on the diffuse flux of ultrahigh energy tau neutrinos from the Pierre Auger Observatory.

    PubMed

    Abraham, J; Abreu, P; Aglietta, M; Aguirre, C; Allard, D; Allekotte, I; Allen, J; Allison, P; Alvarez-Muñiz, J; Ambrosio, M; Anchordoqui, L; Andringa, S; Anzalone, A; Aramo, C; Argirò, S; Arisaka, K; Armengaud, E; Arneodo, F; Arqueros, F; Asch, T; Asorey, H; Assis, P; Atulugama, B S; Aublin, J; Ave, M; Avila, G; Bäcker, T; Badagnani, D; Barbosa, A F; Barnhill, D; Barroso, S L C; Bauleo, P; Beatty, J J; Beau, T; Becker, B R; Becker, K H; Bellido, J A; BenZvi, S; Berat, C; Bergmann, T; Bernardini, P; Bertou, X; Biermann, P L; Billoir, P; Blanch-Bigas, O; Blanco, F; Blasi, P; Bleve, C; Blümer, H; Bohácová, M; Bonifazi, C; Bonino, R; Boratav, M; Brack, J; Brogueira, P; Brown, W C; Buchholz, P; Bueno, A; Burton, R E; Busca, N G; Caballero-Mora, K S; Cai, B; Camin, D V; Caramete, L; Caruso, R; Carvalho, W; Castellina, A; Catalano, O; Cataldi, G; Cazon, L; Cester, R; Chauvin, J; Chiavassa, A; Chinellato, J A; Chou, A; Chye, J; Clark, P D J; Clay, R W; Colombo, E; Conceição, R; Connolly, B; Contreras, F; Coppens, J; Cordier, A; Cotti, U; Coutu, S; Covault, C E; Creusot, A; Criss, A; Cronin, J; Curutiu, A; Dagoret-Campagne, S; Daumiller, K; Dawson, B R; de Almeida, R M; De Donato, C; de Jong, S J; De La Vega, G; de Mello Junior, W J M; de Mello Neto, J R T; DeMitri, I; de Souza, V; del Peral, L; Deligny, O; Della Selva, A; Delle Fratte, C; Dembinski, H; Di Giulio, C; Diaz, J C; Dobrigkeit, C; D'Olivo, J C; Dornic, D; Dorofeev, A; dos Anjos, J C; Dova, M T; D'Urso, D; Dutan, I; DuVernois, M A; Engel, R; Epele, L; Erdmann, M; Escobar, C O; Etchegoyen, A; Facal San Luis, P; Falcke, H; Farrar, G; Fauth, A C; Fazzini, N; Ferrer, F; Ferry, S; Fick, B; Filevich, A; Filipcic, A; Fleck, I; Fonte, R; Fracchiolla, C E; Fulgione, W; García, B; García Gámez, D; Garcia-Pinto, D; Garrido, X; Geenen, H; Gelmini, G; Gemmeke, H; Ghia, P L; Giller, M; Glass, H; Gold, M S; Golup, G; Gomez Albarracin, F; Gómez Berisso, M; Gómez Herrero, R; Gonçalves, P; Gonçalves do Amaral, M; Gonzalez, D; Gonzalez, J G; González, M; Góra, D; Gorgi, A; Gouffon, P; Grassi, V; Grillo, A F; Grunfeld, C; Guardincerri, Y; Guarino, F; Guedes, G P; Gutiérrez, J; Hague, J D; Hamilton, J C; Hansen, P; Harari, D; Harmsma, S; Harton, J L; Haungs, A; Hauschildt, T; Healy, M D; Hebbeker, T; Hebrero, G; Heck, D; Hojvat, C; Holmes, V C; Homola, P; Hörandel, J; Horneffer, A; Horvat, M; Hrabovský, M; Huege, T; Hussain, M; Iarlori, M; Insolia, A; Ionita, F; Italiano, A; Kaducak, M; Kampert, K H; Karova, T; Kégl, B; Keilhauer, B; Kemp, E; Kieckhafer, R M; Klages, H O; Kleifges, M; Kleinfeller, J; Knapik, R; Knapp, J; Koang, D-H; Krieger, A; Krömer, O; Kuempel, D; Kunka, N; Kusenko, A; La Rosa, G; Lachaud, C; Lago, B L; Lebrun, D; Lebrun, P; Lee, J; Leigui de Oliveira, M A; Letessier-Selvon, A; Leuthold, M; Lhenry-Yvon, I; López, R; Lopez Agüera, A; Lozano Bahilo, J; Luna García, R; Maccarone, M C; Macolino, C; Maldera, S; Mancarella, G; Manceñido, M E; Mandat, D; Mantsch, P; Mariazzi, A G; Maris, I C; Marquez Falcon, H R; Martello, D; Martínez, J; Martínez Bravo, O; Mathes, H J; Matthews, J; Matthews, J A J; Matthiae, G; Maurizio, D; Mazur, P O; McCauley, T; McEwen, M; McNeil, R R; Medina, M C; Medina-Tanco, G; Meli, A; Melo, D; Menichetti, E; Menschikov, A; Meurer, Chr; Meyhandan, R; Micheletti, M I; Miele, G; Miller, W; Mollerach, S; Monasor, M; Monnier Ragaigne, D; Montanet, F; Morales, B; Morello, C; Moreno, J C; Morris, C; Mostafá, M; Muller, M A; Mussa, R; Navarra, G; Navarro, J L; Navas, S; Necesal, P; Nellen, L; Newman-Holmes, C; Newton, D; Nguyen Thi, T; Nierstenhoefer, N; Nitz, D; Nosek, D; Nozka, L; Oehlschläger, J; Ohnuki, T; Olinto, A; Olmos-Gilbaja, V M; Ortiz, M; Ortolani, F; Ostapchenko, S; Otero, L; Pacheco, N; Pakk Selmi-Dei, D; Palatka, M; Pallotta, J; Parente, G; Parizot, E; Parlati, S; Pastor, S; Patel, M; Paul, T; Pavlidou, V; Payet, K; Pech, M; Pekala, J; Pelayo, R; Pepe, I M; Perrone, L; Petrera, S; Petrinca, P; Petrov, Y; Pham Ngoc, Diep; Pham Ngoc, Dong; Pham Thi, T N; Pichel, A; Piegaia, R; Pierog, T; Pimenta, M; Pinto, T; Pirronello, V; Pisanti, O; Platino, M; Pochon, J; Privitera, P; Prouza, M; Quel, E J; Rautenberg, J; Redondo, A; Reucroft, S; Revenu, B; Rezende, F A S; Ridky, J; Riggi, S; Risse, M; Rivière, C; Rizi, V; Roberts, M; Robledo, C; Rodriguez, G; Rodríguez Frías, D; Rodriguez Martino, J; Rodriguez Rojo, J; Rodriguez-Cabo, I; Ros, G; Rosado, J; Roth, M; Rouillé-d'Orfeuil, B; Roulet, E; Rovero, A C; Salamida, F; Salazar, H; Salina, G; Sánchez, F; Santander, M; Santo, C E; Santos, E M; Sarazin, F; Sarkar, S; Sato, R; Scherini, V; Schieler, H; Schmidt, A; Schmidt, F; Schmidt, T; Scholten, O; Schovánek, P; Schüssler, F; Sciutto, S J; Scuderi, M; Segreto, A; Semikoz, D; Settimo, M; Shellard, R C; Sidelnik, I; Siffert, B B; Sigl, G

    2008-05-30

    The surface detector array of the Pierre Auger Observatory is sensitive to Earth-skimming tau neutrinos that interact in Earth's crust. Tau leptons from nu(tau) charged-current interactions can emerge and decay in the atmosphere to produce a nearly horizontal shower with a significant electromagnetic component. The data collected between 1 January 2004 and 31 August 2007 are used to place an upper limit on the diffuse flux of nu(tau) at EeV energies. Assuming an E(nu)(-2) differential energy spectrum the limit set at 90% C.L. is E(nu)(2)dN(nu)(tau)/dE(nu)<1.3 x 10(-7) GeV cm(-2) s(-1) sr(-1) in the energy range 2 x 10(17) eV< E(nu)< 2 x 10(19) eV. PMID:18518595

  12. Tau function and Chern-Simons invariant

    E-print Network

    Andrew Mcintyre; Jinsung Park

    2012-09-19

    We define a Chern-Simons invariant for a certain class of infinite volume hyperbolic 3-manifolds. We then prove an expression relating the Bergman tau function on a cover of the Hurwitz space, to the lifting of the function $F$ defined by Zograf on Teichm\\"uller space, and another holomorphic function on the cover of the Hurwitz space which we introduce. If the point in cover of the Hurwitz space corresponds to a Riemann surface $X$, then this function is constructed from the renormalized volume and our Chern-Simons invariant for the bounding 3-manifold of $X$ given by Schottky uniformization, together with a regularized Polyakov integral relating determinants of Laplacians on $X$ in the hyperbolic and singular flat metrics. Combining this with a result of Kokotov and Korotkin, we obtain a similar expression for the isomonodromic tau function of Dubrovin. We also obtain a relation between the Chern-Simons invariant and the eta invariant of the bounding 3-manifold, with defect given by the phase of the Bergman tau function of $X$.

  13. Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

    PubMed Central

    Boluda, Susana; Iba, Michiyo; Zhang, Bin; Raible, Kevin M.; Lee, Virginia M-Y.; Trojanowski, John Q.

    2015-01-01

    Filamentous tau pathologies are hallmark lesions of several neurodegenerative tauopathies including Alzheimer’s disease (AD) and corticobasal degeneration (CBD) which show cell type-specific and topographically distinct tau inclusions. Growing evidence supports templated transmission of tauopathies through functionally interconnected neuroanatomical pathways suggesting that different self-propagating strains of pathological tau could account for the diverse manifestations of neurodegenerative tauopathies. Here, we describe the rapid and distinct cell type-specific spread of pathological tau following intracerebral injections of CBD or AD brain extracts enriched in pathological tau (designated CBD-Tau and AD-Tau, respectively) in young human mutant P301S tau transgenic (Tg) mice (line PS19) ~6–9 months before they show onset of mutant tau transgene-induced tau pathology. At 1 month post-injection of CBD-Tau, tau inclusions developed predominantly in oligodendrocytes of the fimbria and white matter near the injection sites with infrequent intraneuronal tau aggregates. In contrast, injections of AD-Tau in young PS19 mice induced tau pathology predominantly in neuronal perikarya with little or no oligodendrocyte involvement 1 month post-injection. With longer post-injection survival intervals of up to 6 months, CBD-Tau- and AD-Tau-induced tau pathology spread to different brain regions distant from the injection sites while maintaining the cell type-specific pattern noted above. Finally, CA3 neuron loss was detected 3 months post-injection of AD-Tau but not CBD-Tau. Thus, AD-Tau and CBD-Tau represent specific pathological tau strains that spread differentially and may underlie distinct clinical and pathological features of these two tauopathies. Hence, these strains could become targets to develop disease-modifying therapies for CBD and AD. PMID:25534024

  14. Search for pair production of scalar top quarks decaying to a tau lepton and a b quark in 1.96-tev ppbar collisions 

    E-print Network

    Khotilovich, Vadim Gennadyevich

    2009-05-15

    FOR THE SEARCH : : : : : : : : : : : : : : : 1 A. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . 1 B. The Standard Model of Particle Physics and Its Limitations 4 C. Supersymmetry . . . . . . . . . . . . . . . . . . . . . . . . 7 1.... Results . . . . . . . . . . . . . . . . . . . . . . . . 57 2. Electron and Muon Identi cation and E ciency . . . 57 viii CHAPTER Page 3. Tau Identi cation and E ciency . . . . . . . . . . . . 60 4. Lepton Isolation Requirements and E ciencies . . . . 61 5...

  15. Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons.

    PubMed

    Janning, Dennis; Igaev, Maxim; Sündermann, Frederik; Brühmann, Jörg; Beutel, Oliver; Heinisch, Jürgen J; Bakota, Lidia; Piehler, Jacob; Junge, Wolfgang; Brandt, Roland

    2014-11-01

    The microtubule-associated phosphoprotein tau regulates microtubule dynamics and is involved in neurodegenerative diseases collectively called tauopathies. It is generally believed that the vast majority of tau molecules decorate axonal microtubules, thereby stabilizing them. However, it is an open question how tau can regulate microtubule dynamics without impeding microtubule-dependent transport and how tau is also available for interactions other than those with microtubules. Here we address this apparent paradox by fast single-molecule tracking of tau in living neurons and Monte Carlo simulations of tau dynamics. We find that tau dwells on a single microtubule for an unexpectedly short time of ?40 ms before it hops to the next. This dwell time is 100-fold shorter than previously reported by ensemble measurements. Furthermore, we observed by quantitative imaging using fluorescence decay after photoactivation recordings of photoactivatable GFP-tagged tubulin that, despite this rapid dynamics, tau is capable of regulating the tubulin-microtubule balance. This indicates that tau's dwell time on microtubules is sufficiently long to influence the lifetime of a tubulin subunit in a GTP cap. Our data imply a novel kiss-and-hop mechanism by which tau promotes neuronal microtubule assembly. The rapid kiss-and-hop interaction explains why tau, although binding to microtubules, does not interfere with axonal transport. PMID:25165145

  16. Mutant huntingtin alters Tau phosphorylation and subcellular distribution.

    PubMed

    Blum, David; Herrera, Federico; Francelle, Laetitia; Mendes, Tiago; Basquin, Marie; Obriot, Hélène; Demeyer, Dominique; Sergeant, Nicolas; Gerhardt, Ellen; Brouillet, Emmanuel; Buée, Luc; Outeiro, Tiago F

    2015-01-01

    Tau abnormalities play a central role in several neurodegenerative diseases, collectively known as tauopathies. In the present study, we examined whether mutant huntingtin (mHtt), which causes Huntington's disease (HD), modifies Tau phosphorylation and subcellular localization using cell and mouse HD models. Initially, we used novel bimolecular fluorescence complementation assays in live cells to evaluate Tau interactions with either wild type (25QHtt) or mutant huntingtin (103QHtt). While 25QHtt and Tau interacted at the level of the microtubule network, 103QHtt and Tau interacted and formed 'ring-like' inclusions localized in the vicinity of the microtubular organizing center (MTOC). Fluorescence recovery after photobleaching experiments also indicated that, whereas homomeric 103QHtt/103QHtt pairs rapidly re-entered into inclusions, heteromeric 103QHtt/Tau pairs remained excluded from the 'ring-like' inclusions. Interestingly, in vitro Tau relocalization was associated to Tau hyperphosphorylation. Consistent with this observation, we found strong Tau hyperphosphorylation in brain samples from two different mouse models of HD, R6/2 and 140CAG knock-in. This was associated with a significant reduction in the levels of Tau phosphatases (PP1, PP2A and PP2B), with no apparent involvement of major Tau kinases. Thus, the present study strongly suggests that expression of mHtt leads to Tau hyperphosphorylation, relocalization and sequestration through direct protein-protein interactions in inclusion-like compartments in the vicinity of the MTOC. Likewise, our data also suggest that Tau alterations may also contribute to HD pathogenesis. PMID:25143394

  17. UV and optical spectrum variability of T Tau and RY Tau

    NASA Astrophysics Data System (ADS)

    Ismailov, N. Z.; Quliyev, N. Kh.; Khalilov, O. V.; Adigezalzade, H. N.

    2013-03-01

    In this report we have presented results of spectral observations of classical T Tauri type stars T Tau and RY Tau. Observational dates were obtained from following sources: spectrograms of the UV range from the IUE archive data, and spectrograms of the visual range obtained in the 2 m telescope of ShAO of the NAS of Azerbaijan (Ismailov et al. 2010). For both of stars on the Scargle method we have searched a periodicity of variations in equivalent widths of emission lines in the optical and UV ranges. In the RY Tau firstly was detected the periodic variability in MgII ?2800 Å emission doublet intensities with a period of 23 days. The observed period had also revealed with the equivalent widths and displacements of components of H? and H+H? and K CaII emission.

  18. The CDF-II tau physics program triggers, tau ID and preliminary results

    SciTech Connect

    C. Pagliarone et al.

    2003-11-03

    The study of processes containing {tau} leptons in the final state will play an important role at Tevatron Run II. Such final states will be relevant both for electroweak studies and measurements as well as in searches for physics beyond the Standard Model. The present paper discusses the physics opportunities and challenges related to the implementation of new set of triggers able to select events containing tau candidates in the final state. They illustrate, in particular, the physics capabilities for a variety of new physics scenarios such as supersymmetry (SUSY), SUSY with Rp-parity violation, with Bilinear parity violation or models with the violation of lepton flavor. Finally, they present the first Run II results obtained using some of the described tau triggers.

  19. Search for the reactions e+e--->mu+tau- and e+e--->e+tau-

    Microsoft Academic Search

    B. Aubert; M. Bona; D. Boutigny; F. Couderc; Y. Karyotakis; J. P. Lees; V. Poireau; V. Tisserand; A. Zghiche; E. Grauges; A. Palano; J. C. Chen; N. D. Qi; G. Rong; P. Wang; Y. S. Zhu; G. Eigen; I. Ofte; B. Stugu; G. S. Abrams; M. Battaglia; D. N. Brown; J. Button-Shafer; R. N. Cahn; E. Charles; M. S. Gill; Y. Groysman; R. G. Jacobsen; J. A. Kadyk; L. T. Kerth; Yu. G. Kolomensky; G. Kukartsev; G. Lynch; L. M. Mir; T. J. Orimoto; M. Pripstein; N. A. Roe; M. T. Ronan; W. A. Wenzel; P. Del Amo Sanchez; M. Barrett; K. E. Ford; A. J. Hart; T. J. Harrison; C. M. Hawkes; A. T. Watson; T. Held; H. Koch; B. Lewandowski; M. Pelizaeus; K. Peters; T. Schroeder; M. Steinke; J. T. Boyd; J. P. Burke; W. N. Cottingham; D. Walker; D. J. Asgeirsson; T. Cuhadar-Donszelmann; B. G. Fulsom; C. Hearty; N. S. Knecht; T. S. Mattison; J. A. McKenna; A. Khan; P. Kyberd; M. Saleem; D. J. Sherwood; L. Teodorescu; V. E. Blinov; A. D. Bukin; V. P. Druzhinin; V. B. Golubev; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; K. Yu Todyshev; M. Bondioli; M. Bruinsma; M. Chao; S. Curry; I. Eschrich; D. Kirkby; A. J. Lankford; P. Lund; M. Mandelkern; R. K. Mommsen; W. Roethel; D. P. Stoker; S. Abachi; C. Buchanan; S. D. Foulkes; J. W. Gary; O. Long; B. C. Shen; K. Wang; L. Zhang; H. K. Hadavand; E. J. Hill; H. P. Paar; S. Rahatlou; V. Sharma; J. W. Berryhill; C. Campagnari; A. Cunha; B. Dahmes; T. M. Hong; D. Kovalskyi; J. D. Richman; T. W. Beck; A. M. Eisner; C. J. Flacco; C. A. Heusch; J. Kroseberg; W. S. Lockman; G. Nesom; T. Schalk; B. A. Schumm; A. Seiden; P. Spradlin; D. C. Williams; M. G. Wilson; J. Albert; E. Chen; A. Dvoretskii; F. Fang; D. G. Hitlin; I. Narsky; T. Piatenko; F. C. Porter; A. Ryd; G. Mancinelli; B. T. Meadows; K. Mishra; M. D. Sokoloff; F. Blanc; P. C. Bloom; S. Chen; W. T. Ford; J. F. Hirschauer; A. Kreisel; M. Nagel; U. Nauenberg; A. Olivas; W. O. Ruddick; J. G. Smith; K. A. Ulmer; S. R. Wagner; J. Zhang; A. Chen; E. A. Eckhart; A. Soffer; W. H. Toki; R. J. Wilson; F. Winklmeier; Q. Zeng; D. D. Altenburg; E. Feltresi; A. Hauke; H. Jasper; J. Merkel; A. Petzold; B. Spaan; T. Brandt; V. Klose; H. M. Lacker; W. F. Mader; R. Nogowski; J. Schubert; K. R. Schubert; R. Schwierz; J. E. Sundermann; A. Volk; D. Bernard; G. R. Bonneaud; E. Latour; Ch. Thiebaux; M. Verderi; P. J. Clark; W. Gradl; F. Muheim; S. Playfer; A. I. Robertson; Y. Xie; M. Andreotti; D. Bettoni; C. Bozzi; R. Calabrese; G. Cibinetto; E. Luppi; M. Negrini; A. Petrella; L. Piemontese; E. Prencipe; F. Anulli; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; G. Finocchiaro; S. Pacetti; P. Patteri; I. M. Peruzzi; M. Piccolo; M. Rama; A. Zallo; A. Buzzo; R. Contri; M. Lo Vetere; M. M. Macri; M. R. Monge; S. Passaggio; C. Patrignani; E. Robutti; A. Santroni; S. Tosi; G. Brandenburg; K. S. Chaisanguanthum; M. Morii; J. Wu; R. S. Dubitzky; J. Marks; S. Schenk; U. Uwer; W. Bhimji; D. A. Bowerman; P. D. Dauncey; U. Egede; R. L. Flack; J. A. Nash; M. B. Nikolich; W. Panduro Vazquez; D. J. Bard; P. K. Behera; X. Chai; M. J. Charles; U. Mallik; N. T. Meyer; V. Ziegler; J. Cochran; H. B. Crawley; L. Dong; V. Eyges; W. T. Meyer; S. Prell; E. I. Rosenberg; A. E. Rubin; A. V. Gritsan; A. G. Denig; M. Fritsch; G. Schott; N. Arnaud; M. Davier; G. Grosdidier; A. Höcker; F. Le Diberder; V. Lepeltier; A. M. Lutz; A. Oyanguren; S. Pruvot; S. Rodier; P. Roudeau; M. H. Schune; A. Stocchi; W. F. Wang; G. Wormser; C. H. Cheng; D. J. Lange; D. M. Wright; C. A. Chavez; I. J. Forster; J. R. Fry; E. Gabathuler; R. Gamet; K. A. George; D. E. Hutchcroft; D. J. Payne; K. C. Schofield; C. Touramanis; A. J. Bevan; F. Di Lodovico; W. Menges; R. Sacco; G. Cowan; H. U. Flaecher; D. A. Hopkins; P. S. Jackson; T. R. McMahon; S. Ricciardi; F. Salvatore; A. C. Wren; C. L. Davis; J. Allison; N. R. Barlow; R. J. Barlow; Y. M. Chia; C. L. Edgar; G. D. Lafferty; M. T. Naisbit; J. C. Williams; J. I. Yi; C. Chen; W. D. Hulsbergen; A. Jawahery; C. K. Lae; D. A. Roberts; G. Simi; G. Blaylock; C. Dallapiccola; S. S. Hertzbach; X. Li; T. B. Moore; S. Saremi; H. Staengle; R. Cowan; G. Sciolla; S. J. Sekula; M. Spitznagel; F. Taylor; R. K. Yamamoto; H. Kim; S. E. McLachlin; P. M. Patel; S. H. Robertson; A. Lazzaro; V. Lombardo; F. Palombo; J. M. Bauer; L. Cremaldi; V. Eschenburg; R. Godang; R. Kroeger; D. A. Sanders; D. J. Summers; H. W. Zhao; S. Brunet; D. Côté; M. Simard; P. Taras; F. B. Viaud; H. Nicholson; N. Cavallo; G. de Nardo; F. Fabozzi; C. Gatto; L. Lista; D. Monorchio; P. Paolucci; D. Piccolo; C. Sciacca; M. A. Baak; G. Raven; H. L. Snoek; C. P. Jessop; J. M. Losecco; T. Allmendinger; G. Benelli; L. A. Corwin; K. K. Gan; K. Honscheid; D. Hufnagel; H. Kagan; R. Kass; A. M. Rahimi; J. J. Regensburger; R. Ter-Antonyan; Q. K. Wong; N. L. Blount; J. Brau; R. Frey; O. Igonkina; J. A. Kolb; M. Lu; R. Rahmat; N. B. Sinev; D. Strom; J. Strube

    2007-01-01

    We report on a search for the lepton-flavor-violating processes e+e--->mu+tau- and e+e--->e+tau-. The data sample corresponds to an integrated luminosity of 211fb-1 recorded by the BABAR experiment at the SLAC PEP-II asymmetric-energy B Factory at a center-of-mass energy of s=10.58GeV. We find no evidence for a signal and set the 90% confidence level upper limits on the cross sections to

  20. Search for a possible Jpi = 0+, T = 2 resonance in 9Be(tau, gammagamma)12C

    Microsoft Academic Search

    S. S. Hanna; M. Hass; Z. Shkedi; Y. S. Horowitz

    1972-01-01

    A 50 cm3 Ge(Li) detector has been used to re-examine the reaction 9Be(tau, gammagamma)12C over a previously reported resonance at E(tau) = 1.739+\\/-0.007 MeV which was suggested as the lowest T = 2 state in 12C. This state is expected to gamma-decay via the 1+, T = 1 state at 15.11 MeV. However a search with tau bombarding energies ranging

  1. Search for Second-Class Currents in \\tau^-\\to\\omega\\pi^-\

    SciTech Connect

    Aubert, Bernard; Bona, M.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Lopez, L.; Palano, Antimo; Pappagallo, M.; /Bari U. /INFN, Bari; Eigen, G.; Stugu, Bjarne; Sun, L.; /Bergen U.; Abrams, G.S.; Battaglia, M.; Brown, D.N.; Cahn, Robert N.; Jacobsen, R.G.; /LBL, Berkeley /Birmingham U. /Ruhr U., Bochum /Bristol U. /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /Ferrara U. /INFN, Ferrara /Frascati /Genoa U. /INFN, Genoa /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /Consorzio Milano Ricerche /INFN, Milan /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /Napoli Seconda U. /INFN, Naples /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /Padua U. /INFN, Padua /Paris U., VI-VII /Pennsylvania U. /Perugia U. /INFN, Perugia /INFN, Pisa /Princeton U. /Banca di Roma /Frascati /Rostock U. /Rutherford /DAPNIA, Saclay /South Carolina U. /SLAC /Stanford U., Phys. Dept. /SUNY, Albany /Tennessee U. /Texas U. /Texas U., Dallas /Turin U. /INFN, Turin /Trieste U. /INFN, Trieste /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2008-09-03

    We report on an analysis of {tau}{sup -} decaying into {omega}{pi}{sup -}{nu}{sub {tau}} with {omega} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup 0} using data containing nearly 320 million tau pairs collected with the BABAR detector at the PEP-II asymmetric energy B-Factory. We find no evidence for second-class currents and set an upper limit at 0.69% at a 90% confidence level for the ratio of second- to first-class currents.

  2. Evidence for the Higgs-boson Yukawa coupling to tau leptons with the ATLAS detector

    E-print Network

    ATLAS Collaboration

    2015-04-27

    Results of a search for $H \\to \\tau \\tau$ decays are presented, based on the full set of proton-proton collision data recorded by the ATLAS experiment at the LHC during 2011 and 2012. The data correspond to integrated luminosities of 4.5 $\\rm{fb}^{-1}$ and 20.3 $\\rm{fb}^{-1}$ at centre-of-mass energies of $\\sqrt{s}$ = 7 TeV and $\\sqrt{s}$ = 8 TeV respectively. All combinations of leptonic ($\\tau \\to \\ell \

  3. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

    PubMed

    Blair, Laura J; Nordhues, Bryce A; Hill, Shannon E; Scaglione, K Matthew; O'Leary, John C; Fontaine, Sarah N; Breydo, Leonid; Zhang, Bo; Li, Pengfei; Wang, Li; Cotman, Carl; Paulson, Henry L; Muschol, Martin; Uversky, Vladimir N; Klengel, Torsten; Binder, Elisabeth B; Kayed, Rakez; Golde, Todd E; Berchtold, Nicole; Dickey, Chad A

    2013-10-01

    Aggregation of tau protein in the brain is associated with a class of neurodegenerative diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51, encoded by FKBP5) forms a mature chaperone complex with Hsp90 that prevents tau degradation. In this study, we have shown that tau levels are reduced throughout the brains of Fkbp5-/- mice. Recombinant FKBP51 and Hsp90 synergized to block tau clearance through the proteasome, resulting in tau oligomerization. Overexpression of FKBP51 in a tau transgenic mouse model revealed that FKBP51 preserved the species of tau that have been linked to Alzheimer's disease (AD) pathogenesis, blocked amyloid formation, and decreased tangle load in the brain. Alterations in tau turnover and aggregate structure corresponded with enhanced neurotoxicity in mice. In human brains, FKBP51 levels increased relative to age and AD, corresponding with demethylation of the regulatory regions in the FKBP5 gene. We also found that higher FKBP51 levels were associated with AD progression. Our data support a model in which age-associated increases in FKBP51 levels and its interaction with Hsp90 promote neurotoxic tau accumulation. Strategies aimed at attenuating FKBP51 levels or its interaction with Hsp90 have the potential to be therapeutically relevant for AD and other tauopathies. PMID:23999428

  4. Intermediate overtone oscillations of Tau CYG

    NASA Astrophysics Data System (ADS)

    Mkritichian, D. E.; Fedotov, Y. T.; Romanov, Y. S.

    1995-01-01

    According to GCVS (Kholopov et al, 1985) classification Tau Cyg (V=3.70m, F0 IV) is a Delta Scuti type pulsating variable star. However, as is seen from history of its investigations (Paraskevopulos, 1921; Henroteau, 1922; Abt, 1961; Pant et al., 1968; Breger, 1969; Millis, 1969; Fesen, 1973; Bartolini and Dapergolas, 1980; Andrievski and Garbusov, 1987), the conclusions made by different investigators on pulsational activity are ambiguous, and the question on the variability character and possible periodicities remains unsolved for the present, in spite of the stars brightness and the facility for its observations.

  5. WFPC-2 Observations of the Circumstellar Nebulosity of T Tau and HL Tau

    Microsoft Academic Search

    Karl R. Stapelfeldt; C. J. Burrows; J. Krist; J. Trauger; G. Ballester; S. Casertano; J. Clarke; D. Crisp; J. Gallagher; R. Griffiths; J. Hester; J. Hoessel; J. Holtzman; J. Mould; P. Scowen; J. Westphal; A. Watson

    1994-01-01

    T Tauri lies on an arc of reflection nebulosity which extends approximately 3('') N and 2('') SW from the star. This nebula has a characteristic width of 0.5('') , is concave open toward the nearby Burnham's Nebula, and is closely aligned with the optical polarization vector of the system. The morphology T Tau's edge-brightened cometary nebula is similar to models

  6. Tutorial guide to the tau lepton and close-mass lepton pairs

    SciTech Connect

    Perl, M.L.

    1988-10-01

    This is a tutorial guide to present knowledge of the tau lepton, to the tau decay mode puzzle, and to present searches for close-mass lepton pairs. The test is minimal; the emphasis is on figures, tables and literature references. It is based on a lecture given at the 1988 International School of Subnuclear Physics: The Super World III. 54 refs., 9 figs., 7 tabs.

  7. The tau leptons theory and experimental data: Monte Carlo, fits, software and systematic errors

    E-print Network

    Zbigniew Was

    2014-12-09

    Status of tau lepton decay Monte Carlo generator TAUOLA is reviewed. Recent efforts on development of new hadronic currents are presented. Multitude new channels for anomalous tau decay modes and parametrization based on defaults used by BaBar collaboration are introduced. Also parametrization based on theoretical considerations are presented as an alternative. Lesson from comparison and fits to the BaBar and Belle data is recalled. It was found that as in the past, in particular at a time of comparisons with CLEO and ALEPH data, proper fitting, to as detailed as possible representation of the experimental data, is essential for appropriate developments of models of tau decays. In the later part of the presentation, use of the TAUOLA program for phenomenology of W,Z,H decays at LHC is adressed. Some new results, relevant for QED bremsstrahlung in such decays are presented as well.

  8. Loss of tau rescues inflammation-mediated neurodegeneration

    PubMed Central

    Maphis, Nicole; Xu, Guixiang; Kokiko-Cochran, Olga N.; Cardona, Astrid E.; Ransohoff, Richard M.; Lamb, Bruce T.; Bhaskar, Kiran

    2015-01-01

    Neuroinflammation is one of the neuropathological hallmarks of Alzheimer's disease (AD) and related tauopathies. Activated microglia spatially coexist with microtubule-associated protein tau (Mapt or tau)-burdened neurons in the brains of human AD and non-AD tauopathies. Numerous studies have suggested that neuroinflammation precedes tau pathology and that induction or blockage of neuroinflammation via lipopolysaccharide (LPS) or anti-inflammatory compounds (such as FK506) accelerate or block tau pathology, respectively in several animal models of tauopathy. We have previously demonstrated that microglia-mediated neuroinflammation via deficiency of the microglia-specific chemokine (fractalkine) receptor, CX3CR1, promotes tau pathology and neurodegeneration in a mouse model of LPS-induced systemic inflammation. Here, we demonstrate that tau mediates the neurotoxic effects of LPS in Cx3cr1?/? mice. First, Mapt+/+ neurons displayed elevated levels of Annexin V (A5) and TUNEL (markers of neurodegeneration) when co-cultured with LPS-treated Cx3cr1?/?microglia, which is rescued in Mapt?/? neurons. Second, a neuronal population positive for phospho-S199 (AT8) tau in the dentate gyrus is also positive for activated or cleaved caspase (CC3) in the LPS-treated Cx3cr1?/? mice. Third, genetic deficiency for tau in Cx3cr1?/? mice resulted in reduced microglial activation, altered expression of inflammatory genes and a significant reduction in the number of neurons positive for CC3 compared to Cx3cr1?/?mice. Finally, Cx3cr1?/?mice exposed to LPS displayed a lack of inhibition in an open field exploratory behavioral test, which is rescued by tau deficiency. Taken together, our results suggest that pathological alterations in tau mediate inflammation-induced neurotoxicity and that deficiency of Mapt is neuroprotective. Thus, therapeutic approaches toward either reducing tau levels or blocking neuroinflammatory pathways may serve as a potential strategy in treating tauopathies.

  9. Loss of tau rescues inflammation-mediated neurodegeneration.

    PubMed

    Maphis, Nicole; Xu, Guixiang; Kokiko-Cochran, Olga N; Cardona, Astrid E; Ransohoff, Richard M; Lamb, Bruce T; Bhaskar, Kiran

    2015-01-01

    Neuroinflammation is one of the neuropathological hallmarks of Alzheimer's disease (AD) and related tauopathies. Activated microglia spatially coexist with microtubule-associated protein tau (Mapt or tau)-burdened neurons in the brains of human AD and non-AD tauopathies. Numerous studies have suggested that neuroinflammation precedes tau pathology and that induction or blockage of neuroinflammation via lipopolysaccharide (LPS) or anti-inflammatory compounds (such as FK506) accelerate or block tau pathology, respectively in several animal models of tauopathy. We have previously demonstrated that microglia-mediated neuroinflammation via deficiency of the microglia-specific chemokine (fractalkine) receptor, CX3CR1, promotes tau pathology and neurodegeneration in a mouse model of LPS-induced systemic inflammation. Here, we demonstrate that tau mediates the neurotoxic effects of LPS in Cx3cr1 (-/-) mice. First, Mapt (+/+) neurons displayed elevated levels of Annexin V (A5) and TUNEL (markers of neurodegeneration) when co-cultured with LPS-treated Cx3cr1 (-/-)microglia, which is rescued in Mapt (-/-) neurons. Second, a neuronal population positive for phospho-S199 (AT8) tau in the dentate gyrus is also positive for activated or cleaved caspase (CC3) in the LPS-treated Cx3cr1 (-/-) mice. Third, genetic deficiency for tau in Cx3cr1 (-/-) mice resulted in reduced microglial activation, altered expression of inflammatory genes and a significant reduction in the number of neurons positive for CC3 compared to Cx3cr1 (-/-)mice. Finally, Cx3cr1 (-/-)mice exposed to LPS displayed a lack of inhibition in an open field exploratory behavioral test, which is rescued by tau deficiency. Taken together, our results suggest that pathological alterations in tau mediate inflammation-induced neurotoxicity and that deficiency of Mapt is neuroprotective. Thus, therapeutic approaches toward either reducing tau levels or blocking neuroinflammatory pathways may serve as a potential strategy in treating tauopathies. PMID:26089772

  10. Discovering the Higgs bosons of minimal supersymmetry with tau leptons and a bottom quark

    SciTech Connect

    Kao, Chung [Department of Physics and Astronomy, University of Oklahoma, Norman, Oklahoma 73019 (United States); Stanford Linear Accelerator Center, 2575 Sand Hill Road, Menlo Park, California 94025 (United States); Dicus, Duane A. [Center for Particles and Fields, University of Texas, Austin, Texas 78712 (United States); Malhotra, Rahul [Department of Physics and Astronomy, University of Hawaii, Honolulu, Hawaii 96822 (United States); Wang Yili [Department of Physics and Astronomy, University of Oklahoma, Norman, Oklahoma 73019 (United States)

    2008-05-01

    We investigate the prospects for the discovery at the CERN Large Hadron Collider or at the Fermilab Tevatron of neutral Higgs bosons through the channel where the Higgs are produced together with a single bottom quark and the Higgs decays into a pair of tau leptons, bg{yields}b{phi}{sup 0}{yields}b{tau}{sup +}{tau}{sup -}, {phi}{sup 0}=h{sup 0}, H{sup 0}, A{sup 0}. We work within the framework of the minimal supersymmetric model. The dominant physics background from the production of b{tau}{sup +}{tau}{sup -}, j{tau}{sup +}{tau}{sup -} (j=g,u,d,s,c), bbW{sup +}W{sup -}, W+2j, and Wbj is calculated with realistic acceptance cuts and efficiencies. Promising results are found for the CP-odd pseudoscalar (A{sup 0}) and the heavier CP-even scalar (H{sup 0}) Higgs bosons with masses up to one TeV.

  11. Determination of the strange quark mass from Cabibbo-suppressed tau decays with resummed perturbation theory in an effective scheme

    Microsoft Academic Search

    J. G. Körner; F. Krajewski; A. A. Pivovarov

    2001-01-01

    .   We present an analysis of the -corrections to Cabibbo-suppressed -lepton decays employing contour improved resummation within an effective scheme which is an essential new feature as compared\\u000a to previous analyses. The whole perturbative QCD dynamics of the -system is described by the -function of the effective coupling constant and by two -functions for the effective mass parameters of the

  12. Upgraded Breaking Of The HLS Model: A Full Solution to the tau-e+e- and phi Decay Issues And Its Consequences On g-2 VMD Estimates

    E-print Network

    M. Benayoun; P. David; L. DelBuono; F. Jegerlehner

    2011-12-12

    The muon anomalous magnetic moment $a_\\mu$ and the hadronic vacuum polarization are examined using data analyzed within the framework of a suitably broken HLS model. The analysis relies on all available scan data samples and leaves provisionally aside the existing ISR data. Our HLS model based global fit approach allows for a better check of consistency between data sets and we investigate how results depend on different strategies which may be followed. Relying on global fit qualities, we find several acceptable solutions leading to ambiguities in the reconstructed value for $(a_\\mu)_{th}$. Among these, the most conservative solution is $a_\\mu^{\\rm had,LO}[{\\rm HLS \\ improved}]=687.72(4.63) \\times 10^{-10}$ and $(a_\\mu)_{th}=11\\,659\\,175.37(5.31)\\times 10^{-10}$ corresponding to a $4.1 \\sigma$ significance for the difference $\\Delta a_\\mu=(a_\\mu)_{exp}-(a_\\mu)_{th}$. It is also shown that the various contributions accessible through the model yield uniformly a factor 2 improvement of their uncertainty. The breaking procedure implemented in the HLS model is an extension of the former procedure based on the BKY mechanism. This yields a quite satisfactory simultaneous description of most $e^+e^-$ annihilation channels up to and including the $\\phi$ meson ($\\pi^+\\pi^-$, $\\pi^0\\gamma$, $\\eta\\gamma$, $\\pi^+\\pi^-\\pi^0$, $K^+K^-$, $K^0 \\bar{K}^0$) and of a set of 10 (mostly radiative) decay widths of light mesons. It also allows to achieve the proof of consistency between the $e^+e^- \\to \\pi^+\\pi^-$ annihilation and the $\\tau^\\pm \\ra \\pi^\\pm\\pi^0 \

  13. Tau-adaptivity for nonsmooth processes in heterogeneous media

    NASA Astrophysics Data System (ADS)

    Brown, J.; Adams, M.; Knepley, M.

    2014-12-01

    We propose a form of adaptivity based on FAS multigrid and related to the "frozen ?tau technique proposed by Achi Brandt, allowing fine grid work to be avoided in regions with nearly-linear behavior, despite arbitrarily rough coefficients. We investigate indicators for reuse of ?tau, practicality of dynamic load balancing, and experiment with localized plastic yielding in lithosphere dynamics.

  14. PATTERNS & PHENOTYPES Asator, a Tau-Tubulin Kinase Homolog in

    E-print Network

    Johansen, Jorgen

    PATTERNS & PHENOTYPES Asator, a Tau-Tubulin Kinase Homolog in Drosophila Localizes to the Mitotic have used a yeast two-hybrid interaction assay to identify Asator, a tau-tubulin kinase homolog by an Asator-specific mAb as well as by transgenic expression of a GFP-labeled Asator construct, we show

  15. Increased Cerebrospinal Fluid Tau Protein in Multiple Sclerosis

    Microsoft Academic Search

    Elisabeth Kapaki; George P. Paraskevas; Maria Michalopoulou; Konstantinos Kilidireas

    2000-01-01

    Axonal damage is now being recognized as a common finding in multiple sclerosis (MS) lesions and a cause of irreversible neurological damage. Attempts to identify markers of early axonal damage are of great significance. This prompted us to examine the microtubule-associated protein tau in the cerebrospinal fluid (CSF) of patients with MS vs. controls. Tau was measured by double antibody

  16. Avoiding negative populations in explicit Poisson tau-leaping

    Microsoft Academic Search

    Yang Cao; Daniel T. Gillespie; Linda R. Petzold

    2005-01-01

    The explicit tau-leaping procedure attempts to speed up the stochastic simulation of a chemically reacting system by approximating the number of firings of each reaction channel during a chosen time increment tau as a Poisson random variable. Since the Poisson random variable can have arbitrarily large sample values, there is always the possibility that this procedure will cause one or

  17. Tau Leaping Stochastic Simulation Method in P Systems

    Microsoft Academic Search

    Paolo Cazzaniga; Dario Pescini; Daniela Besozzi; Giancarlo Mauri

    2006-01-01

    Abstract. Stochastic simulations based on the tau leaping method are applicable to well stirred chemical reaction systems occurring inside a single xed volume. In this paper we propose a novel method, based on the tau leaping procedure, for the simulation of complex systems composed by several communicating regions. The new method is here applied to dynamical probabilistic P systems, which

  18. Identification of nuclear. tau. isoforms in human neuroblastoma cells

    SciTech Connect

    Loomis, P.A.; Howard, T.H.; Castleberry, R.P.; Binder, L.I. (Univ. of Alabama, Birmingham (United States))

    1990-11-01

    The {tau} proteins have been reported only in association with microtubules and with ribosomes in situ, in the normal central nervous system. In addition, {tau} has been shown to be an integral component of paired helical filaments, the principal constituent of the neurofibrillary tangles found in brains of patients with Alzheimer's disease and of most aged individuals with Down syndrome (trisomy 21). The authors report here the localization of the well-characterized Tau-1 monoclonal antibody to the nucleolar organizer regions of the acrocentric chromosomes and to their interphase counterpart, the fibrillar component of the nucleolus, in human neuroblastoma cells. Similar localization to the nucleolar organizer regions was also observed in other human cell lines and in one monkey kidney cell line but was not seen in non-primate species. Immunochemically, they further demonstrated the existence of the entire {tau} molecule in the isolated nuclei of neuroblastoma cells. Nuclear {tau} proteins, like the {tau} proteins of the paired helical filaments, cannot be extracted in standard SDS-containing electrophoresis sample buffer but require pretreatment with formic acid prior to immunoblot analysis. This work indicates that {tau} may function in processes not directly associated with microtubules and that highly insoluble complexes of {tau} may also play a role in normal cellular physiology.

  19. Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

    PubMed Central

    Mandelkow, Eva-Maria; Mandelkow, Eckhard

    2012-01-01

    Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles, and is therefore of major interest as an indicator of disease mechanisms. Many of the unusual properties of Tau can be explained by its nature as a natively unfolded protein. Examples are the large number of structural conformations and biochemical modifications (phosphorylation, proteolysis, glycosylation, and others), the multitude of interaction partners (mainly microtubules, but also other cytoskeletal proteins, kinases, and phosphatases, motor proteins, chaperones, and membrane proteins). The pathological aggregation of Tau is counterintuitive, given its high solubility, but can be rationalized by short hydrophobic motifs forming ? structures. The aggregation of Tau is toxic in cell and animal models, but can be reversed by suppressing expression or by aggregation inhibitors. This review summarizes some of the structural, biochemical, and cell biological properties of Tau and Tau fibers. Further aspects of Tau as a diagnostic marker and therapeutic target, its involvement in other Tau-based diseases, and its histopathology are covered by other chapters in this volume. PMID:22762014

  20. ORIGINAL ARTICLE Tau Alternative Splicing and Frontotemporal Dementia

    E-print Network

    Wu, Jane Y.

    supranuclear palsy (PSP), FTDs, Down Syndrome (DS), several variants of Prion Diseases and Alzheimer disease of the human tau gene is under complex regulation. Mutations in the tau gene have been identified in patients of tauopa- thies may help in developing effective therapies for neurodegenerative tauopathies and related

  1. RY Tau: A T Tauri Star Driving a Spectacular Jet

    Microsoft Academic Search

    Stephen Skinner

    2009-01-01

    Jets have been discovered in a diverse range of astronomical objects (protostars, stars, galaxies, AGNs) and play an important role in the transport of mass, energy, and angular momentum. To date, the only example of a bipolar X-ray jet in a T Tauri star (TTS) is DG Tau. We propose here to observe RY Tau, which drives a similar bipolar

  2. The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.

    PubMed

    Fontaine, Sarah N; Martin, Mackenzie D; Akoury, Elias; Assimon, Victoria A; Borysov, Sergiy; Nordhues, Bryce A; Sabbagh, Jonathan J; Cockman, Matt; Gestwicki, Jason E; Zweckstetter, Markus; Dickey, Chad A

    2015-07-15

    The pathological accumulation of abnormally hyperphosphorylated and aggregated tau, a neuronal microtubule (MT)-associated protein that functions to maintain MT stability, is implicated in a number of hereditary and sporadic neurodegenerative diseases including frontotemporal dementia and Alzheimer's disease. Targeting tau for the treatment of these diseases is an area of intense interest and toward that end, modulation of cellular molecular chaperones is a potential therapeutic target. In particular, the constitutive Hsp70 isoform, Hsc70, seems highly interconnected with tau, preserving tau protein levels and synergizing with it to assemble MTs. But the relationship between tau and Hsc70, as well as the impact of this interaction in neurons and its therapeutic implications remain unknown. Using a human dominant negative Hsc70 that resembles isoform selective inhibition of this important chaperone, we found for the first time that Hsc70 activity is required to stimulate MT assembly in cells and brain. However, surprisingly, active Hsc70 also requires active tau to regulate MT assembly in vivo, suggesting that tau acts in some ways as a co-chaperone for Hsc70 to coordinate MT assembly. This was despite tau binding to Hsc70 as substrate, as determined biochemically. Moreover, we show that while chronic Hsc70 inhibition damaged MT dynamics, intermittent treatment with a small molecule Hsp70 inhibitor lowered tau in brain tissue without disrupting MT integrity. Thus, in tauopathies, where MT injury would be detrimental to neurons, the unique relationship of tau with the Hsc70 machinery can be exploited to deplete tau levels without damaging MT networks. PMID:25882706

  3. Antibody-Derived In Vivo Imaging of Tau Pathology

    PubMed Central

    Krishnaswamy, Senthilkumar; Lin, Yan; Rajamohamedsait, Wajitha J.; Rajamohamedsait, Hameetha B.; Krishnamurthy, Pavan

    2014-01-01

    Antibodies or their derivatives as imaging probes for pathological tau protein have great potential, but have not been well studied. In particular, smaller, single-chain-variable antibody fragments (scFv's) are attractive for detecting tau lesions in live subjects. Here, we generated libraries of scFv's and identified numerous phospho-tau-selective scFv's. Peripheral injection of one of these scFv's consistently resulted in a strong in vivo brain signal in transgenic tauopathy mice, but not in wild-type or amyloid-? plaque mice. The parent tau antibody provided similar results, albeit with a weaker signal intensity. The imaging signal correlated very well with colocalization of the probe with intraneuronal tau aggregates. Both were associated with markers of endosomes, autophagosomes, and lysosomes, suggesting their interaction in these degradation pathways. Such specific antibody-derived imaging probes have great potential as diagnostic markers for Alzheimer's disease and related tauopathies. PMID:25505335

  4. Tau Functions and Virasoro Symmetries for Drinfeld-Sokolov Hierarchies

    E-print Network

    Chao-Zhong Wu

    2014-05-20

    For each Drinfeld-Sokolov integrable hierarchy associated to affine Kac-Moody algebra, we obtain a uniform construction of tau function by using tau-symmetric Hamiltonian densities, moreover, we represent its Virasoro symmetries as linear/nonlinear actions on the tau function. The relations between the tau function constructed in this paper and those defined for particular cases of Drinfeld-Sokolov hierarchies in the literature are clarified. We also show that, whenever the affine Kac-Moody algebra is simply-laced or twisted, the tau functions of the Drinfeld-Sokolov hierarchy coincide with the solutions of the corresponding Kac-Wakimoto hierarchy from the principal vertex operator realization of the affine algebra.

  5. p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice.

    PubMed

    Walls, Ken C; Ager, Rahasson R; Vasilevko, Vitaly; Cheng, Dave; Medeiros, Rodrigo; LaFerla, Frank M

    2014-07-11

    Alzheimer's disease (AD) is a proteinopathy characterized by the accumulation of ?-amyloid (A?) and tau. To date, clinical trials indicate that A? immunotherapy does not improve cognition. Consequently, it is critical to modulate other aspects of AD pathology. As such, tau represents an excellent target, as its accumulation better correlates with cognitive impairment. To determine the effectiveness of targeting pathological tau, with A? pathology present, we administered a single injection of AT8, or control antibody, into the hippocampus of aged 3xTg-AD mice. Extensive data indicates that phosphorylated Ser(202) and Thr(205) sites of tau (corresponding to the AT8 epitope) represent a pathologically relevant target for AD. We report that immunization with AT8 reduced somatodendritic tau load, p-tau immunoreactivity, and silver stained positive neurons, without affecting A? pathology. We also discovered that tau pathology soon reemerges post-injection, possibly due to persistent A? pathology. These studies provide evidence that targeting p-tau may represent an effective treatment strategy: potentially in conjunction with A? immunotherapy. PMID:24887583

  6. Curr Alzheimer Res . Author manuscript Early Tau pathology involving the septo-hippocampal pathway in a Tau

    E-print Network

    Paris-Sud XI, Université de

    Curr Alzheimer Res . Author manuscript Page /1 7 Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimers disease' Karim Belarbi , Katharina Schindowski.buee@inserm.fr > Abstract Alzheimer s disease is a neurodegenerative disorder characterized by amyloid deposits

  7. Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice

    PubMed Central

    Bi, Mian; Ittner, Arne; Ke, Yazi D.; Götz, Jürgen; Ittner, Lars M.

    2011-01-01

    In Alzheimer's disease (AD) brains, the microtubule-associated protein tau and amyloid-? (A?) deposit as intracellular neurofibrillary tangles (NFTs) and extracellular plaques, respectively. Tau deposits are furthermore found in a significant number of frontotemporal dementia cases. These diseases are characterized by progressive neurodegeneration, the loss of intellectual capabilities and behavioral changes. Unfortunately, the currently available therapies are limited to symptomatic relief. While active immunization against A? has shown efficacy in both various AD mouse models and patients with AD, immunization against pathogenic tau has only recently been shown to prevent pathology in young tau transgenic mice. However, if translated to humans, diagnosis and treatment would be routinely done when symptoms are overt, meaning that the histopathological changes have already progressed. Therefore, we used active immunization to target pathogenic tau in 4, 8, and 18 months-old P301L tau transgenic pR5 mice that have an onset of NFT pathology at 6 months of age. In all age groups, NFT pathology was significantly reduced in treated compared to control pR5 mice. Similarly, phosphorylation of tau at pathological sites was reduced. In addition, increased astrocytosis was found in the oldest treated group. Taken together, our data suggests that tau-targeted immunization slows the progression of NFT pathology in mice, with practical implications for human patients. PMID:22174735

  8. Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

    PubMed Central

    2014-01-01

    Introduction Tau pathology is associated with a number of age-related neurodegenerative disorders. Few treatments have been demonstrated to diminish the impact of tau pathology in mouse models and none are yet effective in humans. Histone deacetylase 6 (HDAC6) is an enzyme that removes acetyl groups from cytoplasmic proteins, rather than nuclear histones. Its substrates include tubulin, heat shock protein 90 and cortactin. Tubastatin A is a selective inhibitor of HDAC6. Modification of tau pathology by specific inhibition of HDAC6 presents a potential therapeutic approach in tauopathy. Methods We treated rTg4510 mouse models of tau deposition and non-transgenic mice with tubastatin (25 mg/kg) or saline (0.9%) from 5 to 7 months of age. Cognitive behavior analysis, histology and biochemical analysis were applied to access the effect of tubastatin on memory, tau pathology and neurodegeneration (hippocampal volume). Results We present data showing that tubastatin restored memory function in rTg4510 mice and reversed a hyperactivity phenotype. We further found that tubastatin reduced the levels of total tau, both histologically and by western analysis. Reduction in total tau levels was positively correlated with memory improvement in these mice. However, there was no impact on phosphorylated forms of tau, either by histology or western analysis, nor was there an impact on silver positive inclusions histologically. Conclusion Potential mechanisms by which HDAC6 inhibitors might benefit the rTg4510 mouse include stabilization of microtubules secondary to increased tubulin acetylation, increased degradation of tau secondary to increased acetylation of HSP90 or both. These data support the use of HDAC6 inhibitors as potential therapeutic agents against tau pathology. PMID:24576665

  9. Measurement of the inclusive branching fraction tau/sup -/. -->. nu/sub tau/. pi. /sup -/. pi. /sup 0/ + neutral meson(s)

    SciTech Connect

    Moses, W.W.

    1986-12-01

    This dissertation measures an inclusive branching fraction of (13.9 +- 2.0/sub -2.4//sup +2.1/)% for the decay tau/sup -/ ..-->.. nu/sub tau/..pi../sup -/..pi../sup 0/ + nh/sup 0/ where h/sup 0/ is a ..pi../sup 0/ or an eta and n greater than or equal to 1. The data sample, obtained with the TPC detector facility at PEP, corresponds to an integrated luminosity of 72 pb/sup -1/ at 29 GeV center of mass energy. The measured value for this branching fraction is somewhat greater than the theoretical prediction and, taking errors into account, resolves the present difference between the inclusive and the sum of the exclusive tau/sup -/ branching fractions into one charged prong. In addition, a lower limit of 8.3% (95% CL) is placed on the branching fraction B(tau/sup -/ ..-->.. nu/sub tau/..pi../sup -/..pi../sup 0/..pi../sup 0/).

  10. Adaptive deployment of model reductions for tau-leaping simulation.

    PubMed

    Wu, Sheng; Fu, Jin; Petzold, Linda R

    2015-05-28

    Multiple time scales in cellular chemical reaction systems often render the tau-leaping algorithm inefficient. Various model reductions have been proposed to accelerate tau-leaping simulations. However, these are often identified and deployed manually, requiring expert knowledge. This is time-consuming and prone to error. In previous work, we proposed a methodology for automatic identification and validation of model reduction opportunities for tau-leaping simulation. Here, we show how the model reductions can be automatically and adaptively deployed during the time course of a simulation. For multiscale systems, this can result in substantial speedups. PMID:26026435

  11. Tau leaping of stiff stochastic chemical systems via local central limit approximation

    NASA Astrophysics Data System (ADS)

    Yang, Yushu; Rathinam, Muruhan

    2013-06-01

    Stiffness manifests in stochastic dynamic systems in a more complex manner than in deterministic systems; it is not only important for a time-stepping method to remain stable but it is also important for the method to capture the asymptotic variances accurately. In the context of stochastic chemical systems, time stepping methods are known as tau leaping. Well known existing tau leaping methods have shortcomings in this regard. The implicit tau method is far more stable than the trapezoidal tau method but underestimates the asymptotic variance. On the other hand, the trapezoidal tau method which estimates the asymptotic variance exactly for linear systems suffers from the fact that the transients of the method do not decay fast enough in the context of very stiff systems. We propose a tau leaping method that possesses the same stability properties as the implicit method while it also captures the asymptotic variance with reasonable accuracy at least for the test system S1?S2. The proposed method uses a central limit approximation (CLA) locally over the tau leaping interval and is referred to as the LCLA-?. The CLA predicts the mean and covariance as solutions of certain differential equations (ODEs) and for efficiency we solve these using a single time step of a suitable low order method. We perform a mean/covariance stability analysis of various possible low order schemes to determine the best scheme. Numerical experiments presented show that LCLA-? performs favorably for stiff systems and that the LCLA-? is also able to capture bimodal distributions unlike the CLA itself. The proposed LCLA-? method uses a split implicit step to compute the mean update. We also prove that any tau leaping method employing a split implicit step converges in the fluid limit to the implicit Euler method as applied to the fluid limit differential equation.

  12. Study of t anti-t production in tau jets channel at CDFII using neural networks

    SciTech Connect

    Amerio, Silvia; /Trento U.

    2005-12-01

    CDF (Collider Detector at Fermilab) is a particle detector located at Fermi National Laboratories, near Chicago. it allows to study decay products of p{bar p} collisions at center-of-mass energy of 1.96 TeV. During its first period of data taking (RunI), CDF observed for the first time the top quark (1995). The current period of data taking (RunII) is devoted to precise measurements of top properties and to search for new physics. This thesis work is about the top decay channel named {tau} + jets. A t{bar t} pair decays in two W bosons and two b quarks. In a {tau} + jets event, one out of the two W decays into two jets of hadrons, while the other produces a {tau} lepton and a neutrino; the {tau} decays semileptonically in one or more charged and neutral pions while b quarks hadronize producing two jets of particles. Thus the final state of a {tau} + jets event has this specific signature: five jets, one {tau}-like, i.e. narrow and with low track multiplicity, two from b quarks, two from a W boson and a large amount of missing energy from two {tau} neutrinos. They search for this signal in 311 pb{sup -1} of data collected with TOP{_}MULTIJET trigger. They use neural networks to separate signal from background and on the selected sample they perform a t{bar t} production cross section measurement. The thesis is structured as follows: in Chapter 1 they outline the physics of top and {tau}, concentrating on their discovery, production mechanisms and current physics results involving them. Chapter 2 is devoted to the description of the experimental setup: the accelerator complex first and CDF detector then. The trigger system is described in Chapter 3, while Chapter 4 shows how particles are reconstructed exploiting information from different CDF subdetectors. With Chapter 5 they begin to present their analysis: we use a feed forward neural network based on a minimization algorithm developed in Trento University, called Reactive Taboo Search (RTS), especially designed to rapidly escape from local minima. Using this neural network, they explore two techniques to select t{bar t} {yields} {tau} + jets events, the first based on a single net, the second on two neural networks in cascade; both techniques are described in Chapter 6, together with the variables used as inputs for the nets. Finally, in Chapter 7 they present a method to measure cross section on the sample of events selected by neural networks.

  13. Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice.

    PubMed

    Martel, Guillaume; Simon, Axelle; Nocera, Sonia; Kalainathan, Sahana; Pidoux, Ludivine; Blum, David; Leclère-Turbant, Sabrina; Diaz, Jorge; Geny, David; Moyse, Emmanuel; Videau, Catherine; Buée, Luc; Epelbaum, Jacques; Viollet, Cécile

    2015-02-01

    Somatostatin (SOM) cortical levels decline in Alzheimer's disease (AD) in correlation with cognitive impairment severity, the latter being closely related to the presence of neurofibrillary tangles. Impaired olfaction is another hallmark of AD tightly related to tau pathology in the olfactory pathways. Recent studies showed that SOM modulates olfactory processing, suggesting that alterations in SOM levels participate to olfactory deficits in AD. Herein, we first observed that human olfactory peduncle and cortex are enriched in SOM cells and fibers, in aged postmortem brains. Then, the possible link between SOM alterations and olfactory deficits was evaluated by exploring the impact of age and tau hyperphosphorylation on olfactory SOM networks and behavioral performances in THY-Tau22 mice, a tauopathy transgenic model. Distinct molecular repertoires of SOM peptide and receptors were associated to sensory or cortical olfactory processing structures. Aging mainly affected SOM neurotransmission in piriform and entorhinal cortex in wild-type mice, although olfactory performances decreased. However, no further olfactory impairment was evidenced in THY-Tau22 mice until 12 months although tau pathology early affected olfactory cortical structures. Thus, tau hyperphosphorylation per se has a limited impact on olfactory performances in THY-Tau22 mice. PMID:25433460

  14. Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

    PubMed Central

    Cook, Casey; Carlomagno, Yari; Gendron, Tania F.; Dunmore, Judy; Scheffel, Kristyn; Stetler, Caroline; Davis, Mary; Dickson, Dennis; Jarpe, Matthew; DeTure, Michael; Petrucelli, Leonard

    2014-01-01

    The accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs) is a neuropathological hallmark of tauopathies, including Alzheimer's disease (AD) and chronic traumatic encephalopathy, but effective therapies directly targeting the tau protein are currently lacking. Herein, we describe a novel mechanism in which the acetylation of tau on KXGS motifs inhibits phosphorylation on this same motif, and also prevents tau aggregation. Using a site-specific antibody to detect acetylation of KXGS motifs, we demonstrate that these sites are hypoacetylated in patients with AD, as well as a mouse model of tauopathy, suggesting that loss of acetylation on KXGS motifs renders tau vulnerable to pathogenic insults. Furthermore, we identify histone deacetylase 6 (HDAC6) as the enzyme responsible for the deacetylation of these residues, and provide proof of concept that acute treatment with a selective and blood–brain barrier-permeable HDAC6 inhibitor enhances acetylation and decreases phosphorylation on tau's KXGS motifs in vivo. As such, we have uncovered a novel therapeutic pathway that can be manipulated to block the formation of pathogenic tau species in disease. PMID:23962722

  15. Chemistry of protosolar-like nebulae: The molecular content of the DM Tau and GG Tau disks.

    NASA Astrophysics Data System (ADS)

    Dutrey, A.; Guilloteau, S.; Guelin, M.

    1997-01-01

    We report the detection of CN, HCN, HNC, CS, HCO^+^, C_2_H and H_2_CO (ortho and para) in the protoplanetary disks of DM Tau and GG Tau. For the first time organic molecules are observed in objects representative of the presolar nebula. These molecules are underabundant with respect to the standard dense clouds. The depletions in the "outer" disk of DM Tau (100

  16. Conformation determines the seeding potencies of native and recombinant Tau aggregates.

    PubMed

    Falcon, Benjamin; Cavallini, Annalisa; Angers, Rachel; Glover, Sarah; Murray, Tracey K; Barnham, Luanda; Jackson, Samuel; O'Neill, Michael J; Isaacs, Adrian M; Hutton, Michael L; Szekeres, Philip G; Goedert, Michel; Bose, Suchira

    2015-01-01

    Intracellular Tau inclusions are a pathological hallmark of several neurodegenerative diseases, collectively known as the tauopathies. They include Alzheimer disease, tangle-only dementia, Pick disease, argyrophilic grain disease, chronic traumatic encephalopathy, progressive supranuclear palsy, and corticobasal degeneration. Tau pathology appears to spread through intercellular propagation, requiring the formation of assembled "prion-like" species. Several cell and animal models have been described that recapitulate aspects of this phenomenon. However, the molecular characteristics of seed-competent Tau remain unclear. Here, we have used a cell model to understand the relationships between Tau structure/phosphorylation and seeding by aggregated Tau species from the brains of mice transgenic for human mutant P301S Tau and full-length aggregated recombinant P301S Tau. Deletion of motifs (275)VQIINK(280) and (306)VQIVYK(311) abolished the seeding activity of recombinant full-length Tau, suggesting that its aggregation was necessary for seeding. We describe conformational differences between native and synthetic Tau aggregates that may account for the higher seeding activity of native assembled Tau. When added to aggregated Tau seeds from the brains of mice transgenic for P301S Tau, soluble recombinant Tau aggregated and acquired the molecular properties of aggregated Tau from transgenic mouse brain. We show that seeding is conferred by aggregated Tau that enters cells through macropinocytosis and seeds the assembly of endogenous Tau into filaments. PMID:25406315

  17. Interferometric Evidence for Warm Dust in the DQ Tau System

    NASA Astrophysics Data System (ADS)

    Boden, Andrew F.; Sargent, A.; Akeson, R.; Carpenter, J.

    2007-12-01

    We report on near-IR interferometric observations of the double-lined pre-main sequence (PMS) binary system DQ Tau. With these observations and the previous spectroscopic orbit & analysis by Mathieu et al 1997 we have estimated a preliminary visual orbit of the DQ Tau system. DQ Tau exhibits a significant near-IR excess, so modeling our interferometric data requires the inclusion of near-IR light from an 'excess' source. Remarkably this excess source appears compact in our data, similar in physical scale to the binary itself, rather than a significantly larger circumbinary disk. This compact emission appears to support arguments by Mathieu et al 1997 and Carr et al 2001 that there is significant near-IR flux from warm gas and dust near the DQ Tau binary, and that dynamical clearing expected in a binary system has not been completely successful in dispersing this material.

  18. Crab-crossing in a Tau-Charm facility

    SciTech Connect

    Voss, G.A.; Paterson, J.M.; Kheifets, S.A.

    1989-07-01

    This report discusses the following topics: crab-crossing; horizontal versus vertical beam crossing; a crab-crossing arrangement for a Tau-Charm facility; tolerance; and beam loading and average current limitations. 7 refs., 1 fig., 1 tab. (LSP)

  19. Measurement of \\mathcal{B}(\\tau^{-}\\-->\\bar{K^{0}}\\pi^{-}\

    SciTech Connect

    Wren, A

    2008-08-13

    A preliminary measurement of the branching fraction {Beta}({tau}{sup -} {yields} K{sub S}{sup 0}{pi}{sup -}{nu}{sub {tau}}) is made using 384.6 fb{sup -1} of e{sup +}e{sup -} collision data provided by the PEP-II collider, operating primarily at {radical}s = 10.58 GeV, and recorded using the BABAR detector. From this they measure: {Beta}({tau}{sup -} {yields} {bar K}{sup 0}{pi}{sup -}{nu}{sub {tau}}) = (0.840 {+-} 0.004(stat) {+-} 0.023(syst))%. This result is the most precise measurement to date and is consistent with the world average.

  20. Tau, prions and A?: the triad of neurodegeneration

    PubMed Central

    Reiniger, Lilla; Lukic, Ana; Linehan, Jacqueline; Rudge, Peter; Collinge, John; Mead, Simon

    2010-01-01

    This article highlights the features that connect prion diseases with other cerebral amyloidoses and how these relate to neurodegeneration, with focus on tau phosphorylation. It also discusses similarities between prion disease and Alzheimer’s disease: mechanisms of amyloid formation, neurotoxicity, pathways involved in triggering tau phosphorylation, links to cell cycle pathways and neuronal apoptosis. We review previous evidence of prion diseases triggering hyperphosphorylation of tau, and complement these findings with cases from our collection of genetic, sporadic and transmitted forms of prion diseases. This includes the novel finding that tau phosphorylation consistently occurs in sporadic CJD, in the absence of amyloid plaques. Electronic supplementary material The online version of this article (doi:10.1007/s00401-010-0691-0) contains supplementary material, which is available to authorized users. PMID:20473510

  1. Magnetic cycles of the planet-hosting star tau Bootis

    Microsoft Academic Search

    J.-F. Donati; C. Moutou; R. Farès; D. Bohlender; C. Catala; M. Deleuil; E. Shkolnik; A. Collier Cameron; M. M. Jardine; G. A. H. Walker

    2008-01-01

    We have obtained new spectropolarimetric observations of the planet-hosting star tau Bootis, using the ESPaDOnS and NARVAL spectropolarimeters at the Canada-France-Hawaii Telescope (CFHT) and Télescope Bernard Lyot (TBL). With this data set, we are able to confirm the presence of a magnetic field at the surface of tau Boo and map its large-scale structure over the whole star. The large-scale

  2. Tau polarization measurements at the LHC in supersymmetric models with a long-lived stau

    SciTech Connect

    Kitano, Ryuichiro; Nakamura, Mitsutoshi [Department of Physics, Tohoku University, Sendai 980-8578 (Japan)

    2010-08-01

    Supersymmetry (SUSY) with a long-lived stau is an attractive scenario in the LHC experiments because one can directly observe stau tracks in each SUSY event, and thus precise measurements of SUSY particle masses are possible. In this scenario, we discuss the possibility to observe/measure parity violation in interactions among SUSY particles. Such a measurement will be important in determining the spins and chiralities of SUSY particles. We use the last step of the cascade-decay chain: {chi}{sup 0{yields}{tau}}(tilde sign){tau}{yields}{tau}(tilde sign)(l{nu}{nu}), where the polarization of the tau lepton can be determined statistically by looking at the energy distribution of the final state lepton. Comparing with the theoretical formula of the neutralino differential decay width, one can extract the size of parity violation in the interaction vertices among the stau, the tau lepton, and the neutralino. We perform a Monte Carlo simulation to see if the effect is visible at the LHC experiments.

  3. Hydration water mobility is enhanced around tau amyloid fibers

    PubMed Central

    Fichou, Yann; Schirò, Giorgio; Gallat, François-Xavier; Laguri, Cedric; Moulin, Martine; Combet, Jérôme; Zamponi, Michaela; Härtlein, Michael; Picart, Catherine; Mossou, Estelle; Lortat-Jacob, Hugues; Colletier, Jacques-Philippe; Tobias, Douglas J.; Weik, Martin

    2015-01-01

    The paired helical filaments (PHF) formed by the intrinsically disordered human protein tau are one of the pathological hallmarks of Alzheimer disease. PHF are fibers of amyloid nature that are composed of a rigid core and an unstructured fuzzy coat. The mechanisms of fiber formation, in particular the role that hydration water might play, remain poorly understood. We combined protein deuteration, neutron scattering, and all-atom molecular dynamics simulations to study the dynamics of hydration water at the surface of fibers formed by the full-length human protein htau40. In comparison with monomeric tau, hydration water on the surface of tau fibers is more mobile, as evidenced by an increased fraction of translationally diffusing water molecules, a higher diffusion coefficient, and increased mean-squared displacements in neutron scattering experiments. Fibers formed by the hexapeptide 306VQIVYK311 were taken as a model for the tau fiber core and studied by molecular dynamics simulations, revealing that hydration water dynamics around the core domain is significantly reduced after fiber formation. Thus, an increase in water dynamics around the fuzzy coat is proposed to be at the origin of the experimentally observed increase in hydration water dynamics around the entire tau fiber. The observed increase in hydration water dynamics is suggested to promote fiber formation through entropic effects. Detection of the enhanced hydration water mobility around tau fibers is conjectured to potentially contribute to the early diagnosis of Alzheimer patients by diffusion MRI. PMID:25918405

  4. The triple binary star EQ Tau with an active component

    SciTech Connect

    Li, K.; Hu, S.-M. [Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment, Institute of Space Science and School of Space Science and Physics, Shandong University, Weihai, Weihai 264209 (China); Qian, S.-B.; He, J.-J., E-mail: kaili@sdu.edu.cn, E-mail: likai@ynao.ac.cn, E-mail: husm@sdu.edu.cn [Yunnan Observatories, Chinese Academy of Sciences, P.O. Box 110, Kunming 650011 (China)

    2014-05-01

    New photometric data of EQ Tau observed in 2010 and 2013 are presented. Light curves obtained in 2000 and 2004 by Yuan and Qian and 2001 by Yang and Liu, together with our two newly determined sets of light curves, were analyzed using the Wilson-Devinney code. The five sets of light curves exhibit very obvious variations, implying that the light curves of EQ Tau show a strong O'Connell effect. We found that EQ Tau is an A-type shallow contact binary with a contact degree of f = 11.8%; variable dark spots on the primary component of EQ Tau were also observed. Using 10 new times of minimum light, together with those collected from the literature, the orbital period change of EQ Tau was analyzed. We found that its orbital period includes a secular decrease (dP/dt = –3.63 × 10{sup –8} days yr{sup –1}) and a cyclic oscillation (A {sub 3} = 0.0058 days and P {sub 3} = 22.7 yr). The secular increase of the period can be explained by mass transfer from the more massive component to the less massive one or/and angular momentum loss due to a magnetic stellar wind. The Applegate mechanism cannot explain the cyclic orbital period change. A probable transit-like event was observed in 2010. Therefore, the cyclic orbital period change of EQ Tau may be due to the light time effect of a third body.

  5. Highly accurate tau-leaping methods with random corrections

    NASA Astrophysics Data System (ADS)

    Hu, Yucheng; Li, Tiejun

    2009-03-01

    We aim to construct higher order tau-leaping methods for numerically simulating stochastic chemical kinetic systems in this paper. By adding a random correction to the primitive tau-leaping scheme in each time step, we greatly improve the accuracy of the tau-leaping approximations. This gain in accuracy actually comes from the reduction in the local truncation error of the scheme in the order of ?, the marching time step size. While the local truncation error of the primitive tau-leaping method is O(?2) for all moments, our Poisson random correction tau-leaping method, in which the correction term is a Poisson random variable, can reduce the local truncation error for the mean to O(?3), and both Gaussian random correction tau-leaping methods, in which the correction term is a Gaussian random variable, can reduce the local truncation error for both the mean and covariance to O(?3). Numerical results demonstrate that these novel methods more accurately capture crucial properties such as the mean and variance than existing methods for simulating chemical reaction systems. This work constitutes a first step to construct high order numerical methods for simulating jump processes. With further refinement and appropriately modified step-size selection procedures, the random correction methods should provide a viable way of simulating chemical reaction systems accurately and efficiently.

  6. Quantitative Analysis of Tau-Microtubule Interaction Using FRET

    PubMed Central

    Di Maïo, Isabelle L.; Barbier, Pascale; Allegro, Diane; Brault, Cédric; Peyrot, Vincent

    2014-01-01

    The interaction between the microtubule associated protein, tau and the microtubules is investigated. A fluorescence resonance energy transfer (FRET) assay was used to determine the distance separating tau to the microtubule wall, as well as the binding parameters of the interaction. By using microtubules stabilized with Flutax-2 as donor and tau labeled with rhodamine as acceptor, a donor-to-acceptor distance of 54 ± 1 Å was found. A molecular model is proposed in which Flutax-2 is directly accessible to tau-rhodamine molecules for energy transfer. By titration, we calculated the stoichiometric dissociation constant to be equal to 1.0 ± 0.5 µM. The influence of the C-terminal tails of ??-tubulin on the tau-microtubule interaction is presented once a procedure to form homogeneous solution of cleaved tubulin has been determined. The results indicate that the C-terminal tails of ?- and ?-tubulin by electrostatic effects and of recruitment seem to be involved in the binding mechanism of tau. PMID:25196605

  7. Search for a low-mass scalar Higgs boson decaying to a tau pair in single-photon decays of ?(1S)

    E-print Network

    Cowan, Ray Franklin

    We search for a low-mass scalar CP-odd Higgs boson, A[superscript 0], produced in the radiative decay of the upsilon resonance and decaying into a ?[superscript +]?[superscript ?] pair: ?(1S) ? ?A[superscript 0]. The ...

  8. Preliminary Measurement of B(tau- ---> K- pi0 nu/tau) Using the BaBar Detector

    SciTech Connect

    Salvatore, F.; /Royal Holloway, U. of London; Lyon, A.J.; /Manchester U.

    2005-07-08

    A preliminary measurement of the branching fraction {Beta}({tau}{sup -} {yields} K{sup -}{pi}{sup 0}{nu}{sub {tau}}) is made using 124.4 fb{sup -1} of e{sup +}e{sup -} collision data provided by the PEP-II accelerator, operating primarily at {radical}s = 10.58 GeV, and recorded using the BABAR detector. They measure: {Beta}({tau}{sup -} {yields} K{sup -} {pi}{sup 0}{nu}{sub {tau}}) = (0.438 {+-} 0.004(stat) {+-} 0.022(syst))%. This result is the world's most precise measurement of this branching fraction to date and is consistent with the world average.

  9. Resonant {tau} Leptogenesis with Observable Lepton Number Violation

    SciTech Connect

    Pilaftsis, Apostolos [School of Physics and Astronomy, University of Manchester, Manchester M13 9PL (United Kingdom)

    2005-08-19

    We consider a minimal extension of the standard model with one singlet neutrino per generation that can realize resonant leptogenesis at the electroweak scale. In particular, the baryon asymmetry in the Universe can be created by lepton-to-baryon conversion of an individual lepton number, for example, that of the {tau} lepton. The current neutrino data can be explained by a simple CP-violating Yukawa texture. The model has several testable phenomenological implications. It contains heavy Majorana neutrinos at the electroweak scale, which can be probed at e{sup +}e{sup -} linear colliders, and predicts e- and {mu}-lepton-number-violating processes, such as 0{nu}{beta}{beta} decay, {mu}{yields}e{gamma}, and {mu}-e conversion in nuclei, with rates that are within reach of experimental sensitivity.

  10. Perturbative QCD relations inspired by hypothetical tau leptons

    SciTech Connect

    Brodsky, Stanley J.

    1999-09-10

    We review our recent works on tests of perturbative QCD, inspired by the relation between the hadronic decay of the {tau} lepton and the e{sup +}e{sup -} annihilation into hadrons. First, we present a set of commensurate scale relations that probe the self-consistency of leading-twist QCD predictions for any observable which defines an effective charge. These tests are independent of the renormalization scheme and scale, and are applicable over wide data ranges. As an example we apply this approach to R{sub e{sup +}e{sup -}}. Second, using a differential form of these commensurate scale relations, we present a method to measure the QCD Gell-Mann-Low {Psi} function.

  11. Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.

    PubMed

    Stancu, Ilie-Cosmin; Vasconcelos, Bruno; Ris, Laurence; Wang, Peng; Villers, Agnès; Peeraer, Eve; Buist, Arjan; Terwel, Dick; Baatsen, Peter; Oyelami, Tutu; Pierrot, Nathalie; Casteels, Cindy; Bormans, Guy; Kienlen-Campard, Pascal; Octave, Jean-Nöel; Moechars, Diederik; Dewachter, Ilse

    2015-06-01

    Prion-like seeding and propagation of Tau-pathology have been demonstrated experimentally and may underlie the stereotyped progression of neurodegenerative Tauopathies. However, the involvement of templated misfolding of Tau in neuronal network dysfunction and behavioral outcomes remains to be explored in detail. Here we analyzed the repercussions of prion-like spreading of Tau-pathology via neuronal connections on neuronal network function in TauP301S transgenic mice. Spontaneous and GABAAR-antagonist-induced neuronal network activity were affected following templated Tau-misfolding using synthetic preformed Tau fibrils in cultured primary neurons. Electrophysiological analysis in organotypic hippocampal slices of Tau transgenic mice demonstrated impaired synaptic transmission and impaired long-term potentiation following Tau-seed induced Tau-aggregation. Intracerebral injection of Tau-seeds in TauP301S mice, caused prion-like spreading of Tau-pathology through functionally connected neuroanatomical pathways. Electrophysiological analysis revealed impaired synaptic plasticity in hippocampal CA1 region 6 months after Tau-seeding in entorhinal cortex (EC). Furthermore, templated Tau aggregation impaired cognitive function, measured in the object recognition test 6 months post-seeding. In contrast, Tau-seeding in basal ganglia and subsequent spreading through functionally connected neuronal networks involved in motor control, resulted in motoric deficits reflected in clasping and impaired inverted grid hanging, not significantly affected following Tau-seeding in EC. Immunostaining, biochemical and electron microscopic analysis in the different models suggested early pathological forms of Tau, including Tau-oligomers, rather than fully mature neurofibrillary tangles (NFTs) as culprits of neuronal dysfunction. We here demonstrate for the first time using in vitro, ex vivo and in vivo models, that prion-like spreading of Tau-misfolding by Tau seeds, along unique neuronal connections, causes neuronal network dysfunction and associated behavioral dysfunction. Our data highlight the potential relevance of this mechanism in the symptomatic progression in Tauopathies. We furthermore demonstrate that the initial site of Tau-seeding thereby determines the behavioral outcome, potentially underlying the observed heterogeneity in (familial) Tauopathies, including in TauP301 mutants. PMID:25862635

  12. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

    PubMed Central

    Luo, Hong-Bin; Xia, Yi-Yuan; Shu, Xi-Ji; Liu, Zan-Chao; Feng, Ye; Liu, Xing-Hua; Yu, Guang; Yin, Gang; Xiong, Yan-Si; Zeng, Kuan; Jiang, Jun; Ye, Keqiang; Wang, Xiao-Chuan; Wang, Jian-Zhi

    2014-01-01

    Intracellular accumulation of the abnormally modified tau is hallmark pathology of Alzheimer’s disease (AD), but the mechanism leading to tau aggregation is not fully characterized. Here, we studied the effects of tau SUMOylation on its phosphorylation, ubiquitination, and degradation. We show that tau SUMOylation induces tau hyperphosphorylation at multiple AD-associated sites, whereas site-specific mutagenesis of tau at K340R (the SUMOylation site) or simultaneous inhibition of tau SUMOylation by ginkgolic acid abolishes the effect of small ubiquitin-like modifier protein 1 (SUMO-1). Conversely, tau hyperphosphorylation promotes its SUMOylation; the latter in turn inhibits tau degradation with reduction of solubility and ubiquitination of tau proteins. Furthermore, the enhanced SUMO-immunoreactivity, costained with the hyperphosphorylated tau, is detected in cerebral cortex of the AD brains, and ?-amyloid exposure of rat primary hippocampal neurons induces a dose-dependent SUMOylation of the hyperphosphorylated tau. Our findings suggest that tau SUMOylation reciprocally stimulates its phosphorylation and inhibits the ubiquitination-mediated tau degradation, which provides a new insight into the AD-like tau accumulation. PMID:25378699

  13. Tau proteins harboring neurodegeneration-linked mutations impair kinesin translocation in vitro.

    PubMed

    Yu, Dezhi; LaPointe, Nichole E; Guzman, Elmer; Pessino, Veronica; Wilson, Leslie; Feinstein, Stuart C; Valentine, Megan T

    2014-01-01

    We tested the hypothesis that mutant tau proteins that cause neurodegeneration and dementia differentially alter kinesin translocation along microtubules (MTs) relative to normal tau in vitro. We employed complementary in vitro motility assays using purified recombinant kinesin, purified recombinant tau, and purified bovine brain ?:? tubulin to isolate interactions among these components without any contribution by cellular regulatory mechanisms. We found that kinesin translocates slower along MTs assembled by any of three independent tau mutants (4-repeat P301L tau, 4-repeat ?N296 tau, and 4-repeat R406W tau) relative to its translocation rate along MTs assembled by normal, 4-repeat wild type (WT) tau. Moreover, the R406W mutation exhibited isoform specific effects; while kinesin translocation along 4-repeat R406W tau assembled MTs is slower than along MTs assembled by 4-repeat WT tau, the R406W mutation had no effect in the 3-repeat tau context. These data provide strong support for the notion that aberrant modulation of kinesin translocation is a component of tau-mediated neuronal cell death and dementia. Finally, we showed that assembling MTs with taxol before coating them with mutant tau obscured effects of the mutant tau that were readily apparent using more physiologically relevant MTs assembled with tau alone, raising important issues regarding the use of taxol as an experimental reagent and novel insights into therapeutic mechanisms of taxol action. PMID:24150109

  14. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1–42 gene transfer models

    PubMed Central

    Hebron, Michaeline L.; Algarzae, Norah K.; Lonskaya, Irina; Moussa, Charbel

    2013-01-01

    Tau hyper-phosphorylation (p-Tau) and neuro-inflammation are hallmarks of neurodegeneration. Previous findings suggest that microglial activation via CX3CL1 promotes p-Tau. We examined inflammation and autophagic p-Tau clearance in lentiviral Tau and mutant P301L expressing rats and used lentiviral A?1–42 to induce p-Tau. Lentiviral Tau or P301L expression significantly increased caspase-3 activity and TNF-?, but CX3CL1 was significantly higher in animals expressing Tau compared to P301L. Lentiviral A?1–42 induced p-Tau 4 weeks post-injection, and increased caspase-3 activation (8-fold) and TNF-? levels. Increased levels of ADAM-10/17 were also detected with p-Tau. IL-6 levels were increased but CX3CL1 did not change in the absence of p-Tau (2 weeks); however, p- Tau reversed these effects, which were associated with increased microglial activity. We observed changes in autophagic markers, including accumulation of autophagic vacuoles (AVs) and p-Tau accumulation in autophagosomes but not lysosomes, suggesting alteration of autophagy. Taken together, microglial activation may promote p-Tau independent of total Tau levels via CX3CL1 signaling, which seems to depend on interaction with inflammatory markers, mainly IL-6. The simultaneous change in autophagy and CX3CL1 signaling suggests communication between microglia and neurons, raising the possibility that accumulation of intraneuronal amyloid, due to lack of autophagic clearance, may lead microglia activation to promote p-Tau as a tag for phagocytic degradation. PMID:23333589

  15. Discovering the Higgs bosons of minimal supersymmetry with tau leptons and a bottom quark

    Microsoft Academic Search

    Chung Kao; Duane A. Dicus; Rahul Malhotra; Wang Yili

    2008-01-01

    We investigate the prospects for the discovery at the CERN Large Hadron Collider or at the Fermilab Tevatron of neutral Higgs bosons through the channel where the Higgs are produced together with a single bottom quark and the Higgs decays into a pair of tau leptons, bgb°b{sup +}, °=h°, H°, A°. We work within the framework of the minimal supersymmetric

  16. Search for tau -> gamma mu: A test of lepton number conservation

    E-print Network

    Ammar, Raymond G.; Ball, S.; Baringer, Philip S.; Coppage, Don; Copty, N.; Davis, Robin E. P.; Hancock, N.; Kelly, M.; Kwak, Nowhan; Lam, H.

    1993-01-01

    A search for the lepton number violating decay of the tau lepton to the gammamu final state has been performed with the CLEO II detector at the Cornell e+e- storage ring CESR. In a data sample that corresponds to an ...

  17. Limit on the diffuse flux of ultrahigh energy tau neutrinos with the surface detector of the Pierre Auger Observatory

    SciTech Connect

    Abraham, J.; De La Vega, G.; Garcia, B.; Videla, M. [Observatorio Meteorologico Parque Gral. San Martin (UTN- FRM/CONICET/CNEA), Mendoza (Argentina); Abreu, P.; Andringa, S.; Assis, P.; Brogueira, P.; Conceicao, R.; Goncalves, P.; Pimenta, M.; Santo, C. E.; Tome, B. [LIP and Instituto Superior Tecnico, Lisboa (Portugal); Aglietta, M.; Bonino, R.; Castellina, A.; Chiavassa, A.; Fulgione, W.; Gorgi, A.; Lucero, A. [Istituto di Fisica dello Spazio Interplanetario (INAF), Universita di Torino and Sezione INFN, Torino (Italy)] (and others)

    2009-05-15

    Data collected at the Pierre Auger Observatory are used to establish an upper limit on the diffuse flux of tau neutrinos in the cosmic radiation. Earth-skimming {nu}{sub {tau}} may interact in the Earth's crust and produce a {tau} lepton by means of charged-current interactions. The {tau} lepton may emerge from the Earth and decay in the atmosphere to produce a nearly horizontal shower with a typical signature, a persistent electromagnetic component even at very large atmospheric depths. The search procedure to select events induced by {tau} decays against the background of normal showers induced by cosmic rays is described. The method used to compute the exposure for a detector continuously growing with time is detailed. Systematic uncertainties in the exposure from the detector, the analysis, and the involved physics are discussed. No {tau} neutrino candidates have been found. For neutrinos in the energy range 2x10{sup 17} eVtau}}}/dE{sub {nu}}<9x10{sup -8} GeV cm{sup -2} s{sup -1} sr{sup -1}.

  18. Search for R-Parity Violating Decays of Sneutrinos to e mu, mu tau, and e tau Pairs in p(p)over-bar Collisions at root s=1.96 TeV

    Microsoft Academic Search

    T. Aaltonen; J. Adelman; B. A. Gonzalez; S. Amerio; D. Amidei; A. Anastassov; A. Annovi; J. Antos; G. Apollinari; J. Appel; A. Apresyan; T. Arisawa; A. Artikov; J. Asaadi; W. Ashmanskas; A. Attal; A. Aurisano; F. Azfar; W. Badgett; A. Barbaro-Galtieri; V. E. Barnes; B. A. Barnett; P. Barria; P. Bartos; G. Bauer; P. H. Beauchemin; F. Bedeschi; D. Beecher; S. Behari; G. Bellettini; J. Bellinger; D. Benjamin; A. Beretvas; A. Bhatti; M. Binkley; D. Bisello; I. Bizjak; R. E. Blair; C. Blocker; B. Blumenfeld; A. Bocci; A. Bodek; V. Boisvert; D. Bortoletto; J. Boudreau; A. Boveia; B. Brau; A. Bridgeman; L. Brigliadori; C. Bromberg; E. Brubaker; J. Budagov; H. S. Budd; S. Budd; K. Burkett; G. Busetto; P. Bussey; A. Buzatu; K. L. Byrum; S. Cabrera; C. Calancha; S. Camarda; M. Campanelli; M. Campbell; F. Canelli; A. Canepa; B. Carls; D. Carlsmith; R. Carosi; S. Carrillo; S. Carron; B. Casal; M. Casarsa; A. Castro; P. Catastini; D. Cauz; V. Cavaliere; M. Cavalli-Sforza; A. Cerri; L. Cerrito; S. H. Chang; Y. C. Chen; M. Chertok; G. Chiarelli; G. Chlachidze; F. Chlebana; K. Cho; D. Chokheli; J. P. Chou; K. Chung; W. H. Chung; Y. S. Chung; T. Chwalek; C. I. Ciobanu; M. A. Ciocci; A. Clark; D. Clark; G. Compostella; M. E. Convery; J. Conway; M. Corbo; M. Cordelli; C. A. Cox; D. J. Cox; F. Crescioli; C. C. Almenar; J. Cuevas; R. Culbertson; J. C. Cully; D. Dagenhart; N. dAscenzo; M. Datta; T. Davies; P. de Barbaro; S. De Cecco; A. Deisher; G. De Lorenzo; M. DellOrso; C. Deluca; L. Demortier; J. Deng; M. Deninno; M. dErrico; A. Di Canto; B. Di Ruzza; J. R. Dittmann; M. DOnofrio; S. Donati; P. Dong; T. Dorigo; S. Dube; K. Ebina; A. Elagin; R. Erbacher; D. Errede; S. Errede; N. Ershaidat; R. Eusebi; H. C. Fang; S. Farrington; W. T. Fedorko; R. G. Feild; M. Feindt; J. P. Fernandez; C. Ferrazza; R. Field; G. Flanagan; R. Forrest; M. J. Frank; M. Franklin; J. C. Freeman; I. Furic; M. Gallinaro; J. Galyardt; F. Garberson; J. E. Garcia; A. F. Garfinkel; P. Garosi; H. Gerberich; D. Gerdes; A. Gessler; S. Giagu; V. Giakoumopoulou; P. Giannetti; K. Gibson; J. L. Gimmell; C. M. Ginsburg; N. Giokaris; M. Giordani; P. Giromini; M. Giunta; G. Giurgiu; V. Glagolev; D. Glenzinski; M. Gold; N. Goldschmidt; A. Golossanov; G. Gomez; G. Gomez-Ceballos; M. Goncharov; O. Gonzalez; I. Gorelov; A. T. Goshaw; K. Goulianos; A. Gresele; S. Grinstein; C. Grosso-Pilcher; U. Grundler; J. G. da Costa; Z. Gunay-Unalan; C. Haber; S. R. Hahn; E. Halkiadakis; B. Y. Han; J. Y. Han; F. Happacher; K. Hara; D. Hare; M. Hare; R. F. Harr; M. Hartz; K. Hatakeyama; C. Hays; M. Heck; J. Heinrich; M. Herndon; J. Heuser; S. Hewamanage; D. Hidas; C. S. Hill; D. Hirschbuehl; A. Hocker; S. Hou; M. Houlden; S. C. Hsu; R. E. Hughes; M. Hurwitz; U. Husemann; M. Hussein; J. Huston; J. Incandela; G. Introzzi; M. Iori; A. Ivanov; E. James; D. Jang; B. Jayatilaka; E. J. Jeon; M. K. Jha; S. Jindariani; W. Johnson; M. Jones; K. K. Joo; S. Y. Jun; J. E. Jung; T. R. Junk; T. Kamon; D. Kar; P. E. Karchin; Y. Kato; R. Kephart; W. Ketchum; J. Keung; V. Khotilovich; B. Kilminster; D. H. Kim; H. S. Kim; H. W. Kim; J. E. Kim; M. J. Kim; S. B. Kim; S. H. Kim; Y. K. Kim; N. Kimura; L. Kirsch; S. Klimenko; B. R. Ko; K. Kondo; D. J. Kong; J. Konigsberg; A. Korytov; A. V. Kotwal; M. Kreps; J. Kroll; D. Krop; N. Krumnack; M. Kruse; V. Krutelyov; T. Kuhr; N. P. Kulkarni; M. Kurata; S. Kwang; A. T. Laasanen; S. Lami; S. Lammel; M. Lancaster; R. L. Lander; K. Lannon; A. Lath; G. Latino; I. Lazzizzera; T. LeCompte; E. Lee; H. S. Lee; J. S. Lee; S. W. Lee; S. Leone; J. D. Lewis; C. J. Lin; J. Linacre; M. Lindgren; E. Lipeles; A. Lister; D. O. Litvintsev; C. Liu; T. Liu; N. S. Lockyer; A. Loginov; L. Lovas; D. Lucchesi; J. Lueck; P. Lujan; P. Lukens; G. Lungu; J. Lys; R. Lysak; D. MacQueen; R. Madrak; K. Maeshima; K. Makhoul; P. Maksimovic; S. Malde; S. Malik; G. Manca; A. Manousakis-Katsikakis; F. Margaroli; C. Marino; A. Martin; V. Martin; M. Martinez; R. Martinez-Ballarin; P. Mastrandrea; M. Mathis; M. E. Mattson; P. Mazzanti; K. S. McFarland; P. McIntyre; R. McNulty; A. Mehta; P. Mehtala; A. Menzione; C. Mesropian; T. Miao; D. Mietlicki; N. Miladinovic; R. Miller; C. Mills; M. Milnik; A. Mitra; G. Mitselmakher; H. Miyake; S. Moed; N. Moggi; M. N. Mondragon; C. S. Moon; R. Moore; M. J. Morello; J. Morlock; P. M. Fernandez; J. Mulmenstadt; A. Mukherjee; T. Muller; P. Murat; M. Mussini; J. Nachtman; Y. Nagai; J. Naganoma; K. Nakamura; I. Nakano; A. Napier; J. Nett; C. Neu; M. S. Neubauer; S. Neubauer; J. Nielsen; L. Nodulman; M. Norman; O. Norniella; E. Nurse; L. Oakes; S. H. Oh; Y. D. Oh; I. Oksuzian; T. Okusawa; R. Orava; K. Osterberg; S. P. Griso; C. Pagliarone; E. Palencia; V. Papadimitriou; A. Papaikonomou; A. A. Paramanov; B. Parks; S. Pashapour; J. Patrick; G. Pauletta; M. Paulini; C. Paus; T. Peiffer; D. E. Pellett; A. Penzo; T. J. Phillips; G. Piacentino; E. Pianori; L. Pinera

    2010-01-01

    We present a search for supersymmetric neutrino (nu) over tilde production using the Tevatron p (p) over bar collision data collected with the CDF II detector and corresponding to an integrated luminosity of 1 fb(-1). We focus on the scenarios predicted by the R-parity violating (RPV) supersymmetric models in which sneutrinos decay to two charged leptons of different flavor. With

  19. Search for Chargino-Neutralino Associated Production in Dilepton Final States with Tau Leptons

    SciTech Connect

    Forrest, R.; Chertok, M.; /UC, Davis

    2011-10-01

    We present a search for chargino and neutralino supersymmetric particles yielding same signed dilepton final states including one hadronically decaying tau lepton using 6.0 fb{sup -1} of data collected by the the CDF II detector. This signature is important in SUSY models where, at high tan {beta}, the branching ratio of charginos and neutralinos to tau leptons becomes dominant. We study event acceptance, lepton identification cuts, and efficiencies. We set limits on the production cross section as a function of SUSY particle mass for certain generic models.

  20. Planet formation in multiple stellar systems: GG Tau A

    NASA Astrophysics Data System (ADS)

    Di Folco, E.; Dutrey, A.; Guilloteau, S.; Le Bouquin, J.-B.; Lacour, S.; Berger, J.-P.; Köhler, R.; Piétu, V.

    2014-12-01

    GG Tau is a hierarchical quadruple system of young, low-mass stars. Because of its well-studied bright circumbinary ring of dust and gas surrounding the main binary GG Tau A, it is a unique laboratory to study planet formation in the disturbed environment of binary/multiple stellar systems. We have started a large observing program of GG Tau A that combines several high-resolution instruments in a multi-wavelength approach. We have recently reported the detection of a new low-mass companion in GG Tau A that turns out to itself be a triple system. This discovery was possible thanks to the very high angular resolution of the near-IR instrument PIONIER on the VLT interferometer, and was confirmed with sub-aperture masking techniques on VLT/NaCo. The detected close binary GG Tau Ab (? = 0.032'', or about 5 AU) provides a natural explanation for two enigmas: the discrepancy between the dynamical mass and the spectral type estimates in GG Tau A, and the absence of dust thermal emission in the vicinity of the Ab component. GRAVITY will provide the adequate angular resolution to complete the astrometric characterization of the close binary in the next 10 years. With now 5 coeval low-mass stars, GG Tau is an ideal laboratory to calibrate stellar evolution tracks at young ages (few Myr). Beyond this peculiar system, GRAVITY also has a strong potential to study the impact of multiplicity on the existence of disks, and in fine on planet formation mechanisms in multiple systems.

  1. Constraints on charged Higgs bosons from D(s)+- -> mu+- nu and D(s)+- -> tau+- nu

    E-print Network

    A. G. Akeroyd; F. Mahmoudi

    2009-04-30

    The decays D(s)+- -> mu+- nu and D(s)+- -> tau+- nu have traditionally been used to measure the D(s)+- meson decay constant f_D(s). Recent measurements at CLEO-c and the B factories suggest a branching ratio for both decays somewhat higher than the Standard Model prediction using f_D(s) from unquenched lattice calculations. The charged Higgs boson (H+-) in the Two Higgs Doublet Model (Type II) would also mediate these decays, but any sizeable contribution from H+- can only suppress the branching ratios and consequently is now slightly disfavoured. It is shown that constraints on the parameters tan(beta) and m_H+- from such decays can be competitive with and complementary to analogous constraints derived from the leptonic meson decays B+- -> tau+- nu_tau and K+- -> mu+- nu_mu, especially if lattice calculations eventually prefer f_D(s) < 250 MeV.

  2. Ultra High Energy Tau Neutrinos and Fluorescence Detectors: A Phenomenological Approach

    E-print Network

    M. Guzzo; C. Moura Jr

    2005-11-25

    We investigate the possibility of detecting ultra-high energy cosmic tau-neutrinos by means of a process involving a double extensive air shower, the so-called Double-Bang Phenomenon. In this process a primary tau-neutrino interacts with an atmospheric quark creating a hadronic extensive air shower that contains a tau which subsequently decays creating a second extensive air shower. The number of these events strongly depends on the cross section and on the flux of ultra-high energy tau-neutrinos arriving at the Earth's atmosphere. We estimate the potential of optical detectors to observe Double-Bang events induced by tau-neutrinos with energies of about 1 EeV whose detection may confirm the maximal mixing observed in the atmospheric neutrinos also for ultra-high energy neutrinos, and give information on the neutrino flux and cross-section. For neutrino-nucleon Standard Model extrapolated cross-section and thick source model of flux (MPR), we estimate an event rate of 0.48/yr for an observatory with two fluorescence detectors with 90% efficiency in the neutrino energy range 0.5 < E_nu < 5 EeV.

  3. Search for charged Higgs bosons decaying via H+ -> tau nu in top quark pair events using pp collision data at sqrt(s) = 7 TeV with the ATLAS detector

    SciTech Connect

    Aad, Georges; Abbott, Brad; Abdallah, Jalal; Abdel Khalek, Samah; Abdelalim, Ahmed Ali; Abdinov, Ovsat; Abi, Babak; Abolins, Maris; AbouZeid, Ossama; Abramowicz, Halina; Abreu, Henso; /SUNY, Albany /Alberta U. /Ankara U. /Dumlupinar U. /Gazi U. /TOBB ETU, Ankara /TAEK, Ankara /Annecy, LAPP /Argonne /Arizona U. /Texas U., Arlington

    2012-04-01

    The results of a search for charged Higgs bosons are presented. The analysis is based on 4.6 fb{sup -1} of proton-proton collision data at {radical}s = 7 TeV collected by the ATLAS experiment at the Large Hadron Collider, using top quark pair events with a {tau} lepton in the final state. The data are consistent with the expected background from Standard Model processes. Assuming that the branching ratio of the charged Higgs boson to a {tau} lepton and a neutrino is 100%, this leads to upper limits on the branching ratio of top quark decays to a b quark and a charged Higgs boson between 5% and 1% for charged Higgs boson masses ranging from 90 GeV to 160 GeV, respectively. In the context of the m{sub h}{sup max} scenario of the MSSM, tan {beta} above 12-26, as well as between 1 and 2-6, can be excluded for charged Higgs boson masses between 90 GeV and 150 GeV.

  4. Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy

    PubMed Central

    Dickey, Chad; Kraft, Clara; Jinwal, Umesh; Koren, John; Johnson, Amelia; Anderson, Laura; Lebson, Lori; Lee, Daniel; Dickson, Dennis; de Silva, Rohan; Binder, Lester I.; Morgan, David; Lewis, Jada

    2009-01-01

    We have extensively analyzed the biochemical and histochemical profiles of the tau protein from the rTg4510 transgenic mouse model in which the animals uniquely develop forebrain tau pathologies similar to those found in human tauopathies. Levels of several soluble phosphorylated tau species were highest at 1 month relative to later time points, suggesting that certain tau hyperphosphorylation events were insufficient to drive tangle formation in young mice. Despite a robust, pre-tangle-like accumulation of phospho-tau in 1-month-old mice, this material was cleared by 3 months, indicating that the young mouse brain either fails to facilitate tau insolubility or possesses an enhanced ability to clear tau relative to the adult. We also found that while heat shock protein expression increased with normal aging, this process was accelerated in rTg4510 mice. Moreover, by exploiting an exon 10 (?) specific antibody, we demonstrated that endogenous mouse tau turnover was slowed in response to human tau over-expression, and that this endogenous tau adopted disease-related properties. These data suggest that a younger brain fails to develop lasting tau pathology despite elevated levels of phosphorylated tau, perhaps because of reduced expression of stress-related proteins. Moreover, we show that the active production of small amounts of abnormal tau protein facilitates dysfunction and accumulation of otherwise normal tau, a significant implication for the pathogenesis of patients with Alzheimer’s disease. PMID:19074615

  5. High Energy Neutrino and Tau Airshowers in Standard and New Physics

    E-print Network

    D. Fargion

    2002-12-01

    High Energy Neutrino may lead to a New High Energy Astronomy. Neutrino interaction in matter at PeVs- EeVs may behave differently from Standard Model predictions because possible TeV Gravity scenario. While traditional km^3 neutrino underground detector will be uneasy to disentangle the Gravity TeV scenario any new Horizontal Tau Air-Shower detectors at PeVs tau energy, beyond Mountain Chains, will be greatly enhanced and it may probe fruit-fully the New TeV Physics imprint. Moreover observing upcoming and horizontal tau air-showers {UPTAUS, HORTAUS} from high mountains toward Mount Chains or along widest Earth Crust crown masses at the Horizons edges, Ultra High Energy,UHE, nu_{tau} and its consequent tau lepton decay in flight, will greatly amplify any single UHE nu_{tau} track and it will test, at highest energies, huge volumes comparable to underground km^3 ones; observing UPTAUS and HORTAUs from higher balloons or satellites at orbit altitudes, at GZK energies, the Horizontal Crown effective Masses may even exceed 150 km^3. These Highest energies (10^{19} eV) nu astronomy are tuned to test the needed abundant nu fluence in GZK Z-Showering model: in this scenario ZeV Ultra High Energy neutrino are hitting on relic light (0.1-5 eV masses) anti-neutrinos, clustered in dark hot halos, creating UHE Z bosons whose decay in flight may be the hadronic secondaries observed on Earth atmosphere as UHECR, isotropically spread along the cosmic edges and clustered toward few correlated BL Lac sources.

  6. Oligomer formation of tau protein hyperphosphorylated in cells.

    PubMed

    Tepper, Katharina; Biernat, Jacek; Kumar, Satish; Wegmann, Susanne; Timm, Thomas; Hübschmann, Sabrina; Redecke, Lars; Mandelkow, Eva-Maria; Müller, Daniel J; Mandelkow, Eckhard

    2014-12-01

    Abnormal phosphorylation ("hyperphosphorylation") and aggregation of Tau protein are hallmarks of Alzheimer disease and other tauopathies, but their causative connection is still a matter of debate. Tau with Alzheimer-like phosphorylation is also present in hibernating animals, mitosis, or during embryonic development, without leading to pathophysiology or neurodegeneration. Thus, the role of phosphorylation and the distinction between physiological and pathological phosphorylation needs to be further refined. So far, the systematic investigation of highly phosphorylated Tau was difficult because a reliable method of preparing reproducible quantities was not available. Here, we generated full-length Tau (2N4R) in Sf9 cells in a well defined phosphorylation state containing up to ?20 phosphates as judged by mass spectrometry and Western blotting with phospho-specific antibodies. Despite the high concentration in living Sf9 cells (estimated ?230 ?m) and high phosphorylation, the protein was not aggregated. However, after purification, the highly phosphorylated protein readily formed oligomers, whereas fibrils were observed only rarely. Exposure of mature primary neuronal cultures to oligomeric phospho-Tau caused reduction of spine density on dendrites but did not change the overall cell viability. PMID:25339173

  7. Oligomer Formation of Tau Protein Hyperphosphorylated in Cells*

    PubMed Central

    Tepper, Katharina; Biernat, Jacek; Kumar, Satish; Wegmann, Susanne; Timm, Thomas; Hübschmann, Sabrina; Redecke, Lars; Mandelkow, Eva-Maria; Müller, Daniel J.; Mandelkow, Eckhard

    2014-01-01

    Abnormal phosphorylation (“hyperphosphorylation”) and aggregation of Tau protein are hallmarks of Alzheimer disease and other tauopathies, but their causative connection is still a matter of debate. Tau with Alzheimer-like phosphorylation is also present in hibernating animals, mitosis, or during embryonic development, without leading to pathophysiology or neurodegeneration. Thus, the role of phosphorylation and the distinction between physiological and pathological phosphorylation needs to be further refined. So far, the systematic investigation of highly phosphorylated Tau was difficult because a reliable method of preparing reproducible quantities was not available. Here, we generated full-length Tau (2N4R) in Sf9 cells in a well defined phosphorylation state containing up to ?20 phosphates as judged by mass spectrometry and Western blotting with phospho-specific antibodies. Despite the high concentration in living Sf9 cells (estimated ?230 ?m) and high phosphorylation, the protein was not aggregated. However, after purification, the highly phosphorylated protein readily formed oligomers, whereas fibrils were observed only rarely. Exposure of mature primary neuronal cultures to oligomeric phospho-Tau caused reduction of spine density on dendrites but did not change the overall cell viability. PMID:25339173

  8. Search for the Higgs boson in lepton, tau, and jets final states

    SciTech Connect

    Abazov, V. M.; et al.

    2013-09-01

    We present a search for the standard model Higgs boson in final states with an electron or muon and a hadronically decaying tau lepton in association with two or more jets using 9.7 fb?1 of Run II Fermilab Tevatron Collider data collected with the D0 detector. The analysis is sensitive to Higgs boson production via gluon fusion, associated vector boson production, and vector boson fusion, followed by the Higgs boson decay to tau lepton pairs or to W boson pairs. The ratios of 95% C.L. upper limits on the cross section times branching ratio to those predicted by the standard model are obtained for orthogonal subsamples that are enriched in either H ? ? ? decays or H ? WW decays, and for the combination of these subsample limits. The observed and expected limit ratios for the combined subsamples at a Higgs boson mass of 125 GeV are 11.3 and 9.0 respectively.

  9. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

    PubMed

    Sydow, Astrid; Van der Jeugd, Ann; Zheng, Fang; Ahmed, Tariq; Balschun, Detlef; Petrova, Olga; Drexler, Dagmar; Zhou, Lepu; Rune, Gabriele; Mandelkow, Eckhard; D'Hooge, Rudi; Alzheimer, Christian; Mandelkow, Eva-Maria

    2011-02-16

    This report describes the behavioral and electrophysiological analysis of regulatable transgenic mice expressing mutant repeat domains of human Tau (Tau(RD)). Mice were generated to express Tau(RD) in two forms, differing in their propensity for ?-structure and thus in their tendency for aggregation ("pro-aggregant" or "anti-aggregant") (Mocanu et al., 2008). Only pro-aggregant mice show pronounced changes typical for Tau pathology in Alzheimer's disease (aggregation, missorting, hyperphosphorylation, synaptic and neuronal loss), indicating that the ?-propensity and hence the ability to aggregate is a key factor in the disease. We now tested the mice with regard to neuromotor parameters, behavior, learning and memory, and synaptic plasticity and correlated this with histological and biochemical parameters in different stages of switching Tau(RD) on or off. The mice are normal in neuromotor tests. However, pro-aggregant Tau(RD) mice are strongly impaired in memory and show pronounced loss of long-term potentiation (LTP), suggesting that Tau aggregation specifically perturbs these brain functions. Remarkably, when the expression of human pro-aggregant Tau(RD) is switched on for ? 10 months and off for ? 4 months, memory and LTP recover, whereas aggregates decrease moderately and change their composition from mixed human plus mouse Tau to mouse Tau only. Neuronal loss persists, but synapses are partially rescued. This argues that continuous presence of amyloidogenic pro-aggregant Tau(RD) constitutes the main toxic insult for memory and LTP, rather than the aggregates as such. PMID:21325519

  10. Implications of $\\mu-\\tau$ Flavored CP Symmetry of Leptons

    E-print Network

    Mohapatra, R N

    2015-01-01

    We discuss gauge models incorporating $\\mu-\\tau$ flavored CP symmetry (called CP$^{\\mu\\tau}$ in the text) in combination with $L_\\mu-L_\\tau$ invariance to understand neutrino mixings and discuss their phenomenological implications. We show that viable leptogenesis in this setting requires that the lightest right-handed neutrino mass must be between $10^9-10^{12}$ GeV and for effective two hierarchical right-handed neutrinos, leptogenesis takes place only in a narrower range of $5\\times 10^{10}-10^{12}$ GeV. A multi-Higgs realization of this idea implies that there must be a pseudoscalar Higgs boson with mass less than 301 GeV. Generically, the vev alignment problem can be naturally avoided in our setting.

  11. Distinct ?-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

    PubMed Central

    Guo, Jing L.; Covell, Dustin J.; Daniels, Joshua P.; Iba, Michiyo; Stieber, Anna; Zhang, Bin; Riddle, Dawn M.; Kwong, Linda K.; Xu, Yan; Trojanowski, John Q.; Lee, Virginia M.Y.

    2013-01-01

    SUMMARY Many neurodegenerative diseases are characterized by the accumulation of insoluble protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer’s disease and Lewy bodies composed of ?-synuclein in Parkinson’s disease. Moreover, different pathological proteins frequently codeposit in disease brains. To test whether aggregated ?-synuclein can directly cross-seed tau fibrillization, we administered preformed ?-synuclein fibrils assembled from recombinant protein to primary neurons and transgenic mice. Remarkably, we discovered two distinct strains of synthetic ?-synuclein fibrils that demonstrated striking differences in the efficiency of cross-seeding tau aggregation, both in neuron cultures and in vivo. Proteinase K digestion revealed conformational differences between the two synthetic ?-synuclein strains and also between sarkosyl-insoluble ?-synuclein extracted from two subgroups of Parkinson’s disease brains. We speculate that distinct strains of pathological ?-synuclein likely exist in neurodegenerative disease brains and may underlie the tremendous heterogeneity of synucleinopathies. PMID:23827677

  12. Tau promotes neurodegeneration via DRP1 mislocalization in vivo

    PubMed Central

    DuBoff, Brian; Götz, Jürgen; Feany, Mel B.

    2012-01-01

    Summary Mitochondrial abnormalities have been documented in Alzheimer’s disease and related neurodegenerative disorders, but the causal relationship between mitochondrial changes and neurodegeneration, as well as the specific mechanisms promoting mitochondrial dysfunction, are not clear. Here we find that expression of human tau results in elongation of mitochondria in both Drosophila and mouse neurons. Elongation is accompanied by mitochondrial dysfunction and cell cycle-mediated cell death, which can be rescued in vivo by genetically restoring the proper balance of mitochondrial fission and fusion. We have previously demonstrated that stabilization of actin by tau is critical for neurotoxicity of the protein. Here we demonstrate a conserved role for actin and myosin in regulating mitochondrial fission, and show that excess actin stabilization inhibits association of the fission protein DRP1 with mitochondria leading to mitochondrial elongation and subsequent neurotoxicity. Our results thus identify actin-mediated disruption of mitochondrial dynamics as a direct mechanism of tau toxicity in neurons in vivo. PMID:22920254

  13. Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies.

    PubMed

    Dai, Chun-ling; Chen, Xia; Kazim, Syed Faraz; Liu, Fei; Gong, Cheng-Xin; Grundke-Iqbal, Inge; Iqbal, Khalid

    2015-04-01

    Intraneuronal accumulation of abnormally hyperphosphorylated tau in the brain is a histopathological hallmark of Alzheimer's disease and a family of related neurodegenerative disorders collectively called tauopathies. At present there is no effective treatment available for these progressive neurodegenerative diseases which are clinically characterized by dementia in mid to old-age. Here we report the treatment of 14-17-months-old 3xTg-AD mice with tau antibodies 43D (tau 6-18) and 77E9 (tau 184-195) to the N-terminal projection domain of tau or mouse IgG as a control by intraperitoneal injection once a week for 4 weeks, and the effects of the passive immunization on reduction of hyperphosphorylated tau, A? accumulation and cognitive performance in these animals. We found that treatment with tau antibodies 43D and 77E9 reduced total tau level, decreased tau hyperphosphorylated at Ser199, Ser202/Thr205 (AT8), Thr205, Ser262/356 (12E8), and Ser396/404 (PHF-1) sites, and a trend to reduce A? pathology. Most importantly, targeting N-terminal tau especially by 43D (tau 6-18) improved reference memory in the Morris water maze task in 3xTg-AD mice. We did not observe any abnormality in general physical characteristics of the treated animals with either of the two antibodies during the course of this study. Taken together, our studies demonstrate for the first time (1) that passive immunization targeting normal tau can effectively clear the hyperphosphorylated protein and possibly reduce A? pathology from the brain and (2) that targeting N-terminal projection domain of tau containing amino acid 6-18 is especially beneficial. Thus, targeting selective epitopes of N-terminal domain of tau may present a novel effective therapeutic opportunity for Alzheimer disease and other tauopathies. PMID:25233799

  14. Preparation of human tau exon-2- and -10-specific monoclonal antibodies for the recognition of brain tau proteins in various mammals.

    PubMed

    Chen, Cao; Lv, Yan; Shi, Qi; Zhang, Bao-Yun; Chen, Li-Na; Xiao, Kang; Sun, Jing; Dong, Xiao-Ping

    2015-08-01

    The aggregations of tau protein in brain tissue have been described in a large number of neurodegenerative diseases; however, due to the lack of tau isoform- or exon-specific antibodies, the exact situations under which various brain tau isoforms can be found and their exact contributions during disease progression remain unknown. Therefore, in this study, we prepared tau exon-specific monoclonal antibodies (mAbs) that recognize different mammalian tau isoforms. Briefly, 3 Balb/c mice were separately immunized (3 mice per antigen) with the recombinant GST-fusion proteins, GST-tE2 and GST-tE10. Two hybridoma cell lines, 4A8 and 3E12, secreting antibodies against human tau exon-2 and -10 were established using the hybridoma technique. The sensitivity and specificity of the prepared mAbs were evaluated using indirect ELISA and western blot analysis. The ability of the prepared mAbs, 4A8 and 3E12, to recognize endogenous tau protein in the brain tissues of various mammals was estimated by immunoprecipitation. Based on the results of various verification methods, we found that the prepared mAbs, 4A8 and 3E12, not only specifically reacted with the individual recombinant GST tau exon fusion proteins, but also correctly recognized the recombinant human tau isoforms containing respective exon sequences, as shown by western blot analysis. Furthermore, western blot analysis and immunoprecipitation assays verified that the mAbs, 4A8 and 3E12, recognized endogenous tau proteins in human brain tissue, as well as tau proteins in a series of mammalian tissues, including goat, bovine, rabbit, hamster and mouse. Thus, in the present study, using the hybridoma technique, we successfully prepared the mAbs, 4A8 against tau exon-2 and 3E12 against tau exon-10, which provide useful tools for determining potential alternations of tau isoforms in neurodegenerative diseases. PMID:26046129

  15. Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies

    PubMed Central

    Irwin, David J.; Cohen, Todd J.; Grossman, Murray; Arnold, Steven E.; McCarty-Wood, Elisabeth; Van Deerlin, Vivianna M.; Lee, Virginia M.-Y.; Trojanowski, John Q.

    2014-01-01

    We have recently shown acetylation of tau at lysine residue 280 (AC-K280) to be a disease-specific modification in Alzheimer disease (AD), corticobasal degeneration, and progressive supranuclear palsy, likely representing a major regulatory tau modification. Herein, we extend our observations using IHC with a polyclonal antibody specific for AC-K280. Thirty brain regions were examined in argyrophilic grain disease (AGD; n = 5), tangle-predominant senile dementia (TPSD; n = 5), Pick disease (n = 4), familial AD (FAD; n = 2; PSEN1 p.G206A and p.S170P), and frontotemporal dementia with parkinsonism linked to chromosome-17 (FTDP-17; n = 2; MAPT p.P301L and IVS10 + 16). All AGD, TPSD, FAD, and FTDP-17 cases had significant AC-K280 reactivity that was similar in severity and distribution to phosphorylated tau. AC-K280 robustly labeled grain pathological characteristics in AGD and was predominantly associated with thioflavin-S–positive neurofibrillary tangles and less reactive in neuropil threads and extracellular tangles in TPSD and FAD. Thioflavin-S–negative neuronal and glial inclusions of patients with FTDP-17 were robustly AC-K280 reactive. A low degree of AC-K280 was found in a subset of 4-repeat tau-containing lesions in Pick disease. AC-K280 is a prominent feature of both neuronal and glial tau aggregations in tauopathies of various etiologies. The close association of AC-K280 with amyloid and pre-amyloid conformations of tau suggests a potential role in tangle maturation and, thus, could serve as a useful biomarker or therapeutic target in a variety of tauopathies. PMID:23885714

  16. Rescue of tau-induced synaptic transmission pathology by paclitaxel

    PubMed Central

    Erez, Hadas; Shemesh, Or A.; Spira, Micha E.

    2014-01-01

    Behavioral and electrophysiological studies of Alzheimer’s disease (AD) and other tauopathies have revealed that the onset of cognitive decline correlates better with synaptic dysfunctions than with hallmark pathologies such as extracellular amyloid-? plaques, intracellular hyperphosphorylated tau or neuronal loss. Recent experiments have also demonstrated that anti-cancer microtubule (MT)-stabilizing drugs can rescue tau-induced behavioral decline and hallmark neuron pathologies. Nevertheless, the mechanisms underlying tau-induced synaptic dysfunction as well as those involved in the rescue of cognitive decline by MTs-stabilizing drugs remain unclear. Here we began to study these mechanisms using the glutaminergic sensory-motoneuron synapse derived from Aplysia ganglia, electrophysiological methods, the expression of mutant-human tau (mt-htau) either pre or postsynaptically and the antimitotic drug paclitaxel. Expression of mt-htau in the presynaptic neurons led to reduced excitatory postsynaptic potential (EPSP) amplitude generated by rested synapses within 3 days of mt-htau expression, and to deeper levels of homosynaptic depression. mt-htau-induced synaptic weakening correlated with reduced releasable presynaptic vesicle pools as revealed by the induction of asynchronous neurotransmitter release by hypertonic sucrose solution. Paclitaxel totally rescued tau-induced synaptic weakening by maintaining the availability of the presynaptic vesicle stores. Postsynaptic expression of mt-htau did not impair the above described synaptic-transmission parameters for up to 5 days. Along with earlier confocal microscope observations from our laboratory, these findings suggest that tau-induced synaptic dysfunction is the outcome of impaired axoplasmic transport and the ensuing reduction in the releasable presynaptic vesicle stores rather than the direct effects of mt-htau or paclitaxel on the synaptic release mechanisms. PMID:24574970

  17. Atmospheric neutrino oscillations and tau neutrinos in ice

    SciTech Connect

    Giordano, Gerardo; Mocioiu, Irina [Department of Physics, Pennsylvania State University, University Park, Pennsylvania 16802 (United States); Mena, Olga [Instituto de Fisica Corpuscular, IFIC, CSIC and Universidad de Valencia (Spain)

    2010-06-01

    The main goal of the IceCube Deep Core Array is to search for neutrinos of astrophysical origins. Atmospheric neutrinos are commonly considered as a background for these searches. We show here that cascade measurements in the Ice Cube Deep Core Array can provide strong evidence for tau neutrino appearance in atmospheric neutrino oscillations. Controlling systematic uncertainties will be the limiting factor in the analysis. A careful study of these tau neutrinos is crucial, since they constitute an irreducible background for astrophysical neutrino detection.

  18. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau

    PubMed Central

    Abisambra, Jose F.; Jinwal, Umesh K.; Suntharalingam, Amirthaa; Arulselvam, Karthik; Brady, Sarah; Cockman, Mattew; Jin, Ying; Zhang, Bo; Dickey, Chad A.

    2012-01-01

    Tau aggregation and amyloidogenesis are common hallmarks for neurodegenerative disorders called tauopathies. The molecular chaperone network constitutes the cellular defense against insults such as tau aggregation. However, chaperone effects on tau are dichotomous. Loss of tau’s microtubule-binding activity facilitates an inappropriate chaperone interaction that promotes an amyloidogenic tau conformation. Conversely, other chaperones are capable of promoting tau clearance. Here, we demonstrate that a critical contributor to tau triage is the DnaJ-binding domain of Hsp70 proteins. In particular, over-expression of the constitutive DnaJ, DnaJA1, mediated tau clearance, while knockdown facilitated tau accumulation. This clearance was not specific to distinct pathogenic tau species. The activity of DnaJA1 was attenuated by concomitant increases in Hsp70. Tau reductions facilitated by DnaJA1 were dependent on the integrity of lysines known to be poly-ubiquitinated in human Alzheimer’s brain. In vivo, DnaJA1 and tau levels were inversely correlated. The effects of DnaJA1 were partially specific: DnaJA1 reduced the levels of a polyQ protein but had no significant effect on ?-synuclein levels. These data suggest that DnaJA1 triages all tau species for ubiquitin-dependent clearance mechanisms. Moreover, the levels of DnaJA1 and Hsp70 seem to play against each other with regard to tau: as DnaJA1 levels increase, tau levels are reduced, but this can be prevented if Hsp70 levels are simultaneously induced. Thus, the DnaJ repertoire possibly represents a powerful set of genetic modifiers for tau pathogenesis. Further investigations, could provide new insights about triage decisions that facilitate or prevent amyloidogenesis of tau and other proteins associated with neurodegenerative disease. PMID:22343013

  19. Ecological-floristic analysis of soil algae and cyanobacteria on the Tra-Tau and Yurak-Tau Mounts, Bashkiria

    NASA Astrophysics Data System (ADS)

    Bakieva, G. R.; Khaibullina, L. S.; Gaisina, L. A.; Kabirov, R. R.

    2012-09-01

    The species composition of the soil algae and cyanobacteria in the Tra-Tau and Yurak-Tau mountains is represented by 136 species belonging to five phyla: Cyanobacteria (56 species), Chlorophyta (52 species), Xanthophyta (13 species), Bacillariophyta (12 species), and Eustigmatophyta (3 species). Hantzschia amphioxys var. amphioxys, Hantzschia amphioxys var. constricta, Klebsormidium flaccidum, Leptolyngbya foveolarum, Luticola mutica, Navicula minima var. minima, Nostoc punctiforme, Phormidium jadinianum, Phormidium autumnale, and Pinnularia borealis were identified more often than other species. The composition of the algal flora depended on the soil properties; the higher plants also had a significant influence on the species composition of the soil algae.

  20. High Angular Resolution Radio Observations of the HL\\/XZ Tau Region: Mapping the 50 AU Protoplanetary Disk Around HL Tau and Resolving XZ Tau S Into a 13 AU Binary

    Microsoft Academic Search

    Carlos Carrasco-González; Luis F. Rodríguez; Guillem Anglada; Salvador Curiel

    2009-01-01

    We present new 7 mm and archive 1.3 cm high angular resolution observations of the HL\\/XZ Tau region made with the Very Large Array. At 7 mm, the emission from HL Tau seems to arise in a clumpy disk with radius of the order of 25 AU. The 1.3 cm emission from XZ Tau shows the emission from a binary

  1. Validation of ELISA methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer's disease studies.

    PubMed

    Lachno, D Richard; Romeo, Martin J; Siemers, Eric R; Vanderstichele, Hugo; Coart, Els; Konrad, Robert J; Zajac, Joseph J; Talbot, Jayne A; Jensen, Hans F; Sethuraman, Gopalan; Demattos, Ronald B; May, Patrick C; Dean, Robert A

    2011-01-01

    Tau measurements in cerebrospinal fluid (CSF) are gaining acceptance as aids to diagnosis of Alzheimer's disease (AD) and differentiation from other dementias. Two ELISA assays, the INNOTEST® hTAU Ag and the INNOTEST® PHOSPHO-TAU(181P) for quantification of t-tau and p-tau181 respectively, have been validated to regulatory standards. Validation parameters were determined by repeated testing of human CSF pools. Specimens from Phase 2 studies of the ?-secretase inhibitor semagacestat and the therapeutic antibody solanezumab at baseline and following 12-14 weeks of treatment were also tested. Estimated intra-assay CV for repeated testing of 3 CSF pools were ?11.5% and RE varied between -14.1% and +6.4%. Inter-assay CV for t-tau was <5% and RE was within ±8%. For p-tau181, inter-assay CV was <9% and RE was within ±2.5%. Total CV (intra-assay plus inter-assay) were below 10% for both analytes. Up to 20-fold dilutional linearity was demonstrated for both analytes. Stability of t-tau and p-tau181 was demonstrated in CSF during five freeze-thaw cycles at ?-20 °C and ?-70 °C and at 18-22 °C for up to 24 h. Neither semagacestat nor solanezumab interfered with either assay. Inter-individual t-tau and p-tau181 concentrations were highly variable but intra-individual variations were small. These assays are suitable for analysis of CSF t-tau and p-tau181 in a single laboratory supporting multi-center AD clinical trials. No effect of treatment with semagacestat or solanezumab was observed in response to three months of drug administration. PMID:21694458

  2. Modifications of the tau protein and their varied effects on aggregation and function

    E-print Network

    Combs, Benjamin Neal

    2013-05-31

    the evidence suggests several different functions for tau, mice lacking the tau gene initially seemed to suffer few observable defects outside of minor alterations in microtubule patterning (59). However, more recent studies have indicated some behavioral... changes and brain atrophy occur in aged tau-knockout mice (60, 61). Despite the seeming lack of evidence for essential functions of the protein, tau has retained the focus of investigators for many years due to its obvious dysfunction in tauopathies...

  3. Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

    Microsoft Academic Search

    Marc Mercken; Marc Vandermeeren; Ursula Liibke; Jan Six; Jef Boons; André Voorde; Jean-Jacques Martin; Jan Gheuens

    1992-01-01

    A modified form of the microtubule-associated protein Tau is the major component of the paired helical filaments (PHF) found in Alzheimer's disease. The characterization of these posttranslational Tau modifications is hindered by the lack of sufficient PHF-Tau-specific markers. Here we describe several monoclonal antibodies, prepared by immunization with PHF, two of which showed a selective specificity for PHF-Tau without cross-reactivity

  4. Monte Carlo Simulations of Tau Proteins: Effect of Phosphorylation

    PubMed Central

    Jho, Y.S.; Zhulina, E.B.; Kim, M.W.; Pincus, P.A.

    2010-01-01

    We perform Monte Carlo simulations of tau proteins bound to a cylinder that mimics a microtubule (MT), and then study them in solution. Tau protein binds to a highly anionic MT surface to stabilize the cylindrical structure of MT. The negatively charged tail domain floats away from the anionic MT surface while positively charged tau segments localize near the MT surface. Monte Carlo simulations demonstrate that, in 3RS tau isoform (which has three imperfect repeats (R) short (S) isoform), amino acids are more condensed near a highly charged interface compared to 4RL isoform (which has four imperfect repeats (R) long (L) isoform). In 4RL isoform, amino acids in tail domain stay mostly apart from the MT surface. In the bulk solution, dephosphorylated taus are separated due to Coulomb repulsion between similarly charged isoforms. Moderate phosphorylation of 3RS isoform decreases average intermolecular distance between dephosphorylated and phosphorylated taus and lead to their overlap. Further phosphorylation does not change noticeably the intermolecular distances. PMID:20959078

  5. HL Tau 76 after the XCOV13 Campaign: Progress Report

    Microsoft Academic Search

    N. Dolez

    1998-01-01

    We present a short account of ongoing reduction and interpretation of the observations of HL Tau 76 obtained during the WET campaign of 1996. We also included in the discussion the results of several single-site observations, obtained between 1989 and 1996. In introduction, we give a short synopsis of works about the same star, published by several authors from 1968

  6. Measurement of the tau-lepton electronic branching fraction

    E-print Network

    Ammar, Raymond G.; Ball, S.; Baringer, Philip S.; Coppage, Don; Copty, N.; Davis, Robin E. P.; Hancock, N.; Kelly, M.; Kwak, Nowhan; Lam, H.

    1992-12-01

    The tau lepton electronic branching fraction has been measured with the CLEO II detector at the Cornell Electron Storage Ring as B(e)=0.1749 +/- 0.0014 +/- 0.0022, with the first error statistical and the second systematic. The measurement involves...

  7. Integral tau methods for stiff stochastic chemical systems

    NASA Astrophysics Data System (ADS)

    Yang, Yushu; Rathinam, Muruhan; Shen, Jinglai

    2011-01-01

    Tau leaping methods enable efficient simulation of discrete stochastic chemical systems. Stiff stochastic systems are particularly challenging since implicit methods, which are good for stiffness, result in noninteger states. The occurrence of negative states is also a common problem in tau leaping. In this paper, we introduce the implicit Minkowski-Weyl tau (IMW-?) methods. Two updating schemes of the IMW-? methods are presented: implicit Minkowski-Weyl sequential (IMW-S) and implicit Minkowski-Weyl parallel (IMW-P). The main desirable feature of these methods is that they are designed for stiff stochastic systems with molecular copy numbers ranging from small to large and that they produce integer states without rounding. This is accomplished by the use of a split step where the first part is implicit and computes the mean update while the second part is explicit and generates a random update with the mean computed in the first part. We illustrate the IMW-S and IMW-P methods by some numerical examples, and compare them with existing tau methods. For most cases, the IMW-S and IMW-P methods perform favorably.

  8. The inversion symmetry of the WDVV equations and tau functions

    NASA Astrophysics Data System (ADS)

    Liu, Si-Qi; Xu, Dingdian; Zhang, Youjin

    2012-12-01

    For two solutions of the WDVV equations that are related by the inversion symmetry, we show that the associated principal hierarchies of integrable systems are related by a reciprocal transformation, and the tau functions of the hierarchies are related by a Legendre-type transformation. We also consider relationships between the Virasoro constraints and the topological deformations of the principal hierarchies.

  9. The Spatial Distribution of Fluorescent H$_2$ Near T Tau

    E-print Network

    José Saucedo; Nuria Calvet; Lee Hartmann; John Raymond

    2003-04-29

    New subarcsecond FUV observations of T Tau with HST/STIS show spatially resolved structures in the 2"x2" area around the star. The structures show in multiline emission of fluorescent H_2 pumped by Lyman alpha. One emission structure follows the cavity walls observed around T Tau N in scattered light in the optical. A temperature greater or equal to 1000K is required to have enough population in the H_2 to produce the observed fluorescent lines; in the cool environment of the T Tau system, shock heating is required to achieve this temperature at distances of a few tens of AU. Fluorescent H_2 along the cavity wall represents the best evidence to date for the action of low-density, wide-opening-angle outflows driving cavities into the molecular medium at scales smaller than 100 AU. A southern region of emission consists of two arcs, with shape and orientation similar to the arcs of H_2 2.12 microns and forbidden line emission crossing the outflow associated with the embedded system T Tau S. This region is located near the centroid of forbidden line emission at the blueshifted lobe of the N-S outflow.

  10. Tau-Coupling Revisited 103 When Is Behavioral Data

    E-print Network

    Jegelka, Stefanie

    and the moving target. In line with the theory, previous research has found a linear relationship between that were independent of the target's move- ment but led to successful interception. We found be considered as evidence for the tau-coupling theory. Key Words: time-to-contact, model testing, sensorimotor

  11. Kinematic analysis and error modeling of TAU parallel robot

    Microsoft Academic Search

    Hongliang Cui; Zhenqi Zhu; Zhongxue Gan; Torgny Brogardh

    2005-01-01

    The TAU robot presents a new configuration of parallel robots with three degrees of freedom. This robotic configuration is well adapted to perform with a high precision and high stiffness within a large working range compared with a serial robot. It has the advantages of both parallel robots and serial robots. In this paper, the kinematic modeling and error modeling

  12. Squirrel monkeys infected with BSE develop Tau pathology

    PubMed Central

    Piccardo, Pedro; Cervenak, Juraj; Yakovleva, Oksana; Gregori, Luisa; Pomeroy, Kitty; Cook, Anthony; Muhammad, F Salih; Seuberlich, Torsten; Cervenakova, Larisa; Asher, David M

    2011-01-01

    Squirrel monkeys were experimentally infected with the classical bovine spongiform encephalopathy (BSE) agent. Two to four years later, six of the monkeys developed alterations in interactive behavior, cognition and other neurological signs typical of transmissible spongiform encephalopathy (TSE). At necropsy, all brains showed pathological changes similar to those described in variant Creutzfeldt-Jakob disease (vCJD) of humans, except that the squirrel monkey brains contained no PrP amyloid plaques typical of that disease. Constant neuropathological features included spongiform degeneration, gliosis, deposition of abnormal prion protein (PrPTSE) and many deposits of abnormally phosphorylated tau protein (p-Tau) in several areas of the cerebrum and cerebellum. Western blots showed large amounts of proteinase-K-resistant prion protein in the central nervous system. The striking absence of PrP plaques (prominent in brains of cynomolgus macaques with both experimental BSE and vCJD and in patients with vCJD) reinforces the conclusion that the host plays a major role in determining the neuropathology of TSEs. Results of this study suggest that p-Tau, found in the brains of all BSE-infected monkeys, might play a role in the pathogenesis of TSEs. Whether p-Tau contributes to development of disease or appears as a secondary change late in the course of illness remains to be determined. PMID:22018806

  13. Neurofibrillary Degeneration in Progressive Supranuclear Palsy andCorticobasal Degeneration. Tau Pathologies with Exclusively \\

    Microsoft Academic Search

    N. Sergeant; A. Wattez; A. Delacourte

    1999-01-01

    Pathological tau proteins that constitute the basic matrix of neuronal inclusions observed in numerous neurodegenerative disorders are disease specific. This is mainly the consequence of the aggregation of specific sets of tau isoforms according to the diseases, i.e., six isoforms in Alzheimer's disease (AD) and exclusively the three tau isoforms lacking the corresponding sequence of exon 10 (E102) in Pick's

  14. Immunological characterization of the region of tau protein that is bound to Alzheimer paired helical filaments.

    PubMed

    Caputo, C B; Wischik, C; Novak, M; Scott, C W; Brunner, W F; De Garcini, E M; Lo, M M; Norris, T E; Salama, A I

    1992-01-01

    Tau protein is known to be present in the paired helical filaments (PHFs) of Alzheimer brains. This study investigated the fragments of tau protein that remain bound to pronase-treated PHFs and conditions that lead to the release of these tau fragments from the core structure of the PHF. Antibody 423 reacted with PHFs and with fetal rat tau but not with adult rat tau, pig tau, or recombinant human tau. Three other antibodies that react with the tubulin binding region of tau only reacted with PHFs after they were disrupted with formic acid or guanidine. Other antibodies that recognize tau sequences C terminal to the tubulin binding region also recognized pronase-treated PHFs. Antibodies SMI34 and T3P that recognize phosphorylated epitopes were reactive with pronase-treated PHFs. Tau fragments from the PHF were solubilized by acid or guanidine treatment. These findings suggest that the fragments of tau that are bound to PHFs and protected from pronase digestion include sequences from the tubulin binding region to the C terminus of tau. In addition, some of these sequences appear to be conformationally or post-translationally modified. PMID:1381814

  15. School of Mori and Pacific Development Tau Rua Mano Undergraduate Scholarships

    E-print Network

    Waikato, University of

    School of Mori and Pacific Development Tau Rua Mano Undergraduate Scholarships TAU RUA MANO UNDERGRADUATE SCHOLARSHIPS 2010 BACKGROUND The Tau Rua Mano Undergraduate Scholarships were established in 1999 by the School of Mori and Pacific Development with the first Scholarships awarded for the year 2000. The purpose

  16. A measurement of the ({tau}) polarization at the Z resonance with the DELPHI detector at LEP

    SciTech Connect

    Wong Chan, A.

    1993-07-01

    The polarization of {tau} leptons produced in the reaction e{sup +}e{sup {minus}} {yields} {tau}{sup +}{tau}{sup {minus}} near the peak of the Z{degree} resonance has been measured using a sample of 24904 {tau}{sup +}{tau}{sup {minus}} events, with an estimated background of 1.5%. We have selected 4562 {tau} {yields} e{nu}{bar {nu}} 2218 {tau} {yields} {pi}{nu} and 5133 {tau} {yields} {rho}{nu} candidates. The mean value obtained is P{sub {tau}} = {minus}0.176 {plus_minus} 0.029. This corresponds to a ratio of the neutral current vector to the axial-vector coupling constants of the {tau} lepton of g{sub V}{sup {tau}}/g{sub A}{sup {tau}} = 0.088 {plus_minus} 0.014. This leads to a value of the electroweak mixing angle of sin{sup 2}{theta}{sub W} = 0.2280 {plus_minus} 0.0036. This result is in good agreement with previous measurements of the weak mixing angle from the study of the Z{degree} lineshape and the forward-backward asymmetries in the processes Z{degree} {yields} l{sup +}l{sup {minus}} and Z{degree} {yields} q{bar q}.

  17. Tau in cerebrospinal fluids: establishment of the sandwich ELISA with antibody specific to the repeat sequence in tau

    Microsoft Academic Search

    Hirosi Mori; Kenji Hosoda; Etsuro Matsubara; Tadakatsu Nakamoto; Yoshiko Furiya; Riuko Endoh; Mihoko Usami; Mikio Shoji; Shoichi Maruyama; Shunsaku Hirai

    1995-01-01

    Clinical diagnosis for Alzheimer's disease (AD) is provided by the criteria of DSMIV and clinical progress in addition to imaging analysis with MRI after negative screening. The final exclusive diagnosis iis confirmed by the neuropathological findings of neurofibrillary tangles and senile plaques in autopsy brains. We developed a new ELISA system to measure the amount of tau in cerebrospinal fluids

  18. Search for the standard model Higgs boson in tau lepton final states

    SciTech Connect

    Abazov, Victor Mukhamedovich; et al.

    2012-08-01

    We present a search for the standard model Higgs boson in final states with an electron or muon and a hadronically decaying tau lepton in association with zero, one, or two or more jets using data corresponding to an integrated luminosity of up to 7.3 fb{sup -1} collected with the D0 detector at the Fermilab Tevatron collider. The analysis is sensitive to Higgs boson production via gluon gluon fusion, associated vector boson production, and vector boson fusion, and to Higgs boson decays to tau lepton pairs or W boson pairs. Observed (expected) limits are set on the ratio of 95% C.L. upper limits on the cross section times branching ratio, relative to those predicted by the Standard Model, of 14 (22) at a Higgs boson mass of 115 GeV and 7.7 (6.8) at 165 GeV.

  19. Different Populations of Human Locus Ceruleus Neurons Contain Heavy Metals or Hyperphosphorylated Tau: Implications for Amyloid-? and Tau Pathology in Alzheimer's Disease.

    PubMed

    Pamphlett, Roger; Kum Jew, Stephen

    2015-01-01

    A marked loss of locus ceruleus (LC) neurons is a striking pathological feature of Alzheimer's disease (AD). LC neurons are particularly prone to taking up circulating toxicants such as heavy metals, and hyperphosphorylated tau (tau(HYP)) appears early in these neurons. In an attempt to find out if both heavy metals and tau(HYP) could be damaging LC neurons, we looked in the LC neurons of 21 sporadic AD patients and 43 non-demented controls for the heavy metals mercury, bismuth, and silver using autometallography, and for tau(HYP) using AT8 immunostaining. Heavy metals or tau(HYP) were usually seen in separate LC neurons, and rarely co-existed within the same neuron. The number of heavy metal-containing LC neurons did not correlate with the number containing tau(HYP). Heavy metals therefore appear to occupy a mostly different population of LC neurons to those containing tau(HYP), indicating that the LC in AD is vulnerable to two different assaults. Reduced brain noradrenaline from LC damage is linked to amyloid-? deposition, and tau(HYP) in the LC may seed neurofibrillary tangles in other neurons. A model is described, incorporating the present findings, that proposes that the LC plays a part in both the amyloid-? and tau pathologies of AD. PMID:25547633

  20. Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain

    PubMed Central

    Caillierez, Raphaëlle; Bégard, Séverine; Lécolle, Katia; Deramecourt, Vincent; Zommer, Nadège; Dujardin, Simon; Loyens, Anne; Dufour, Noëlle; Aurégan, Gwennaëlle; Winderickx, Joris; Hantraye, Philippe; Déglon, Nicole; Buée, Luc; Colin, Morvane

    2013-01-01

    Most models for tauopathy use a mutated form of the Tau gene, MAPT, that is found in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and that leads to rapid neurofibrillary degeneration (NFD). Use of a wild-type (WT) form of human Tau protein to model the aggregation and associated neurodegenerative processes of Tau in the mouse brain has thus far been unsuccessful. In the present study, we generated an original “sporadic tauopathy-like” model in the rat hippocampus, encoding six Tau isoforms as found in humans, using lentiviral vectors (LVs) for the delivery of a human WT Tau. The overexpression of human WT Tau in pyramidal neurons resulted in NFD, the morphological characteristics and kinetics of which reflected the slow and sporadic neurodegenerative processes observed in sporadic tauopathies, unlike the rapid neurodegenerative processes leading to cell death and ghost tangles triggered by the FTDP-17 mutant Tau P301L. This new model highlights differences in the molecular and cellular mechanisms underlying the pathological processes induced by WT and mutant Tau and suggests that preference should be given to animal models using WT Tau in the quest to understand sporadic tauopathies. PMID:23609018

  1. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation

    PubMed Central

    Abisambra, Jose F.; Jinwal, Umesh K.; Blair, Laura J.; O’Leary, John C.; Li, Qingyou; Brady, Sarah; Wang, Li; Guidi, Chantal E.; Zhang, Bo; Nordhues, Bryce A.; Cockman, Matthew; Suntharalingham, Amirthaa; Li, Pengfei; Jin, Ying; Atkins, Christopher A.; Dickey, Chad A.

    2013-01-01

    In Alzheimer’s disease (AD), the mechanisms of neuronal loss remain largely unknown. While tau pathology is closely correlated with neuronal loss, how its accumulation may lead to activation of neurotoxic pathways is unclear. Here we show that tau increased the levels of ubiquitinated proteins in the brain and that this triggered activation of the Unfolded Protein Response (UPR). This suggested that tau was interfering with protein quality control in the endoplasmic reticulum (ER). Consistent with this, ubiquitin was found to associate with the ER in human AD brains and rTg4510 tau transgenic mouse brains, but this was not always co-localized with tau. The increased levels of ubiquitinated protein were accompanied by increased levels of phosphorylated PERK, a marker that indicates UPR activation. Importantly, depleting soluble tau levels in cells and brain could reverse UPR activation. Tau accumulation facilitated its deleterious interaction with ER membrane and associated proteins that are essential for ER-associated degradation (ERAD), including VCP and Hrd1. Based on this, the effects of tau accumulation on ERAD efficiency were evaluated using the CD3? reporter, an ERAD substrate. Indeed, CD3? accumulated in both in vitro and in vivo models of tau over-expression and AD brains. These data suggest that soluble tau impairs ERAD, and the result is activation of the UPR. The reversibility of this process, however, suggests that tau-based therapeutics could significantly delay this type of cell death and consequently disease progression. PMID:23719816

  2. Acetylation: a new key to unlock tau’s role in neurodegeneration

    PubMed Central

    2014-01-01

    The identification of tau protein as a major constituent of neurofibrillary tangles spurred considerable effort devoted to identifying and validating pathways through which therapeutics may alleviate tau burden in Alzheimer’s disease and related tauopathies, including chronic traumatic encephalopathy associated with sport- and military-related injuries. Most tau-based therapeutic strategies have previously focused on modulating tau phosphorylation, given that tau species present within neurofibrillary tangles are hyperphosphorylated on a number of different residues. However, the recent discovery that tau is modified by acetylation necessitates additional research to provide greater mechanistic insight into the spectrum of physiological consequences of tau acetylation, which may hold promise as a novel therapeutic target. In this review, we discuss recent findings evaluating tau acetylation in the context of previously accepted notions regarding tau biology and pathophysiology. We also examine the evidence demonstrating the neuroprotective and beneficial consequences of inhibiting histone deacetylase (HDAC)6, a tau deacetylase, including its effect on microtubule stabilization. We also discuss the rationale for pharmacologically modulating HDAC6 in tau-based pathologies as a novel therapeutic strategy. PMID:25031639

  3. A Search for B -> tau nu Recoiling Against B- -> D0 l- nu X

    SciTech Connect

    Aubert, B.

    2009-12-17

    The authors present a search for the decay B{sup +} {yields} {ell}{sup +}{nu}{sub {ell}} ({ell} = {tau}, {mu}, or e) in (458.9 {+-} 5.1) x 10{sup 6} B{bar B} pairs recorded with the BABAR detector at the PEP-II B-Factory. They search for these B decays in a sample of B{sup +}B{sup -} events where one B-meson is reconstructed as B{sup -} {yields} D{sup 0}{ell}{sup -}{bar {nu}}X. Using the method of Feldman and Cousins, they obtain {Beta}(B{sup +} {yields} {tau}{sup +}{nu}{sub {tau}}) = (1.7 {+-} 0.8 {+-} 0.2) x 10{sup -4}, which excludes zero at 2.3{sigma}. They interpret the central value in the context of the Standard Model and find the B meson decay constant to be f{sub B}{sup 2} = (62 {+-} 31) x 10{sup 3} MeV{sup 2}. They find no evidence for B{sup +} {yields} e{sup +}{nu}{sub e} and B{sup +} {yields} {mu}{sup +}{nu}{sub {mu}} and set upper limits at the 90% C.L. {Beta}(B{sup +} {yields} e{sup +}{nu}{sub e}) < 0.8 x 10{sup -5} and {Beta}(B{sup +} {yields} {mu}{sup +}{nu}{sub {mu}}) < 1.1 x 10{sup -5}.

  4. Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.

    PubMed

    Kadavath, Harindranath; Hofele, Romina V; Biernat, Jacek; Kumar, Satish; Tepper, Katharina; Urlaub, Henning; Mandelkow, Eckhard; Zweckstetter, Markus

    2015-06-16

    The structure, dynamic behavior, and spatial organization of microtubules are regulated by microtubule-associated proteins. An important microtubule-associated protein is the protein Tau, because its microtubule interaction is impaired in the course of Alzheimer's disease and several other neurodegenerative diseases. Here, we show that Tau binds to microtubules by using small groups of evolutionary conserved residues. The binding sites are formed by residues that are essential for the pathological aggregation of Tau, suggesting competition between physiological interaction and pathogenic misfolding. Tau residues in between the microtubule-binding sites remain flexible when Tau is bound to microtubules in agreement with a highly dynamic nature of the Tau-microtubule interaction. By binding at the interface between tubulin heterodimers, Tau uses a conserved mechanism of microtubule polymerization and, thus, regulation of axonal stability and cell morphology. PMID:26034266

  5. Distinct tau prion strains propagate in cells and mice and define different tauopathies

    PubMed Central

    Sanders, David W.; Kaufman, Sarah K.; DeVos, Sarah L.; Sharma, Apurwa M.; Mirbaha, Hilda; Li, Aimin; Barker, Scarlett J.; Foley, Alex; Thorpe, Julian R.; Serpell, Louise C.; Miller, Timothy M.; Grinberg, Lea T.; Seeley, William W.; Diamond, Marc I.

    2014-01-01

    Summary Prion-like propagation of tau aggregation may underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations (“strains”) in vivo that link structure to patterns of pathology. We now find that tau meets this criterion. Stably expressed tau repeat domain indefinitely propagates distinct amyloid conformations in a clonal fashion in culture. Reintroduction of tau from these lines into naïve cells re-establishes identical clones. We produced two strains in vitro that induce distinct pathologies in vivo as determined by successive inoculations into three generations of transgenic mice. Immunopurified tau from these mice re-creates the original strains in culture. We used the cell system to isolate tau strains from 29 patients with 5 different tauopathies, finding that different diseases are associated with different sets of strains. Tau thus demonstrates essential characteristics of a prion. This may explain the phenotypic diversity of tauopathies and could enable more effective diagnosis and therapy. PMID:24857020

  6. High Angular Resolution Radio Observations of the HL/XZ Tau Region: Mapping the 50 AU Protoplanetary Disk around HL Tau and Resolving XZ Tau S into a 13 AU Binary

    E-print Network

    Carrasco-Gonzalez, Carlos; Anglada, Guillem; Curiel, Salvador

    2009-01-01

    We present new 7 mm and archive 1.3 cm high angular resolution observations of the HL/XZ Tau region made with the VLA. At 7 mm, the emission from HL Tau seems to be arising in a clumpy disk with radius of order 25 AU. The 1.3 cm emission from XZ Tau shows the emission from a binary system with 0"3 (42 AU) separation, known from previous optical/IR observations. However, at 7 mm, the southern radio component resolves into a binary with 0"09 (13 AU) separation, suggesting that XZ Tau is actually a triple star system. We suggest that the remarkable ejection of gas from the XZ Tau system observed with the HST may be related to a periastron passage of this newly discovered close binary system.

  7. Cerebrospinal Fluid P-Tau181P: Biomarker for Improved Differential Dementia Diagnosis

    PubMed Central

    Struyfs, Hanne; Niemantsverdriet, Ellis; Goossens, Joery; Fransen, Erik; Martin, Jean-Jacques; De Deyn, Peter P.; Engelborghs, Sebastiaan

    2015-01-01

    The goal of this study is to investigate the value of tau phosphorylated at threonine 181 (P-tau181P) in the Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarker panel for differential dementia diagnosis in autopsy confirmed AD and non-AD patients. The study population consisted of 140 autopsy confirmed AD and 77 autopsy confirmed non-AD dementia patients. CSF concentrations of amyloid-? peptide of 42 amino acids (A?1–42), total tau protein (T-tau), and P-tau181P were determined with single analyte ELISA-kits (INNOTEST®, Fujirebio, Ghent, Belgium). Diagnostic accuracy was assessed through receiver operating characteristic (ROC) curve analyses to obtain area under the curve (AUC) values and to define optimal cutoff values to discriminate AD from pooled and individual non-AD groups. ROC curve analyses were only performed on biomarkers and ratios that differed significantly between the groups. Pairwise comparison of AUC values was performed by means of DeLong tests. The A?1–42/P-tau181P ratio (AUC?=?0.770) performed significantly better than A?1–42 (AUC?=?0.677, P?=?0.004), T-tau (AUC?=?0.592, P?tau (AUC?=?0.678, P?=?0.001), while P-tau181P (AUC?=?0.720) performed significantly better than T-tau (AUC?=?0.592, P?tau181P (AUC?=?0.894) discriminated AD from frontotemporal dementia significantly better than A?1–42 (AUC?=?0.776, P?=?0.020) and T-tau (AUC?=?0.746, P?=?0.004), while P-tau181P/T-tau (AUC?=?0.958) significantly improved the differentiation between AD and Creutzfeldt-Jakob disease as compared to A?1–42 (AUC?=?0.688, P?=?0.004), T-tau (AUC?=?0.874, P?=?0.040), and A?1–42/P-tau181P (AUC?=?0.760, P?=?0.003). In conclusion, this study demonstrates P-tau181P is an essential component of the AD CSF biomarker panel, and combined assessment of A?1–42, T-tau, and P-tau181P renders, to present date, the highest diagnostic power to discriminate between AD and non-AD dementias.

  8. The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases.

    PubMed

    Mawal-Dewan, M; Henley, J; Van de Voorde, A; Trojanowski, J Q; Lee, V M

    1994-12-01

    The paired helical filaments (PHFs) in Alzheimer's disease neurofibrillary tangles are composed of PHF-tau which is thought to be hyperphosphorylated because several residues in postmortem samples of PHF-tau and human fetal tau are phosphorylated while the corresponding sites are not phosphorylated in autopsy-derived normal adult human brain tau. To determine how the phosphorylation of these sites is regulated, we isolated tau from rat brains at different embryonic and postnatal ages in the presence of okadaic acid to obtain tau in its most native in situ phosphorylation state. Fetal tau was highly phosphorylated from embryonic day 18 (E18) until postnatal day 11 (P11). Thereafter, the levels of fetal tau diminished as did its phosphorylation state concomitant with the appearance of the five adult tau isoforms. Several phosphorylation-dependent antibodies (i.e. AT270, AT8, AT180, T3P, and PHF1) that recognize PHF-tau also recognized these tau isoforms, albeit at reduced levels in the mature rat brain. This suggests that Thr172, Ser193, Thr222, Ser387, and Ser395 are normal sites of phosphorylation in rat brain tau. The inclusion of OK in the microtubule assembly buffers did not alter the ability of tau to bind microtubules at any age. However, phosphatases were activated and kinases were down-regulated in the rat brain after P12 since adult tau proteins were partially dephosphorylated at and beyond this time in the absence of OK. Protein phosphatase 2A (PP2A) and 2B (PP2B) activities in the adult rat brain extracts dephosphorylated tau efficiently, but protein phosphatases in extracts of the P6 rat brain did not have a similar effect. This suggests that the sensitivity of tau to OK after P12 may be regulated by the de novo induction of adult brain phosphatases. Finally, PP2A and/or PP2B in adult rat brain extracts dephosphorylated tau in a site-specific manner. Thus, PP2A and PP2B (or closely related phosphatases) may regulate the phosphorylation state of adult tau isoforms in vivo, and the generation of PHF-tau in the AD brain may result from the abnormal inactivation of similar phosphatases. PMID:7983034

  9. Cerebrospinal Fluid P-Tau181P: Biomarker for Improved Differential Dementia Diagnosis.

    PubMed

    Struyfs, Hanne; Niemantsverdriet, Ellis; Goossens, Joery; Fransen, Erik; Martin, Jean-Jacques; De Deyn, Peter P; Engelborghs, Sebastiaan

    2015-01-01

    The goal of this study is to investigate the value of tau phosphorylated at threonine 181 (P-tau181P) in the Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker panel for differential dementia diagnosis in autopsy confirmed AD and non-AD patients. The study population consisted of 140 autopsy confirmed AD and 77 autopsy confirmed non-AD dementia patients. CSF concentrations of amyloid-? peptide of 42 amino acids (A?1-42), total tau protein (T-tau), and P-tau181P were determined with single analyte ELISA-kits (INNOTEST(®), Fujirebio, Ghent, Belgium). Diagnostic accuracy was assessed through receiver operating characteristic (ROC) curve analyses to obtain area under the curve (AUC) values and to define optimal cutoff values to discriminate AD from pooled and individual non-AD groups. ROC curve analyses were only performed on biomarkers and ratios that differed significantly between the groups. Pairwise comparison of AUC values was performed by means of DeLong tests. The A?1-42/P-tau181P ratio (AUC?=?0.770) performed significantly better than A?1-42 (AUC?=?0.677, P?=?0.004), T-tau (AUC?=?0.592, P?tau (AUC?=?0.678, P?=?0.001), while P-tau181P (AUC?=?0.720) performed significantly better than T-tau (AUC?=?0.592, P?tau181P (AUC?=?0.894) discriminated AD from frontotemporal dementia significantly better than A?1-42 (AUC?=?0.776, P?=?0.020) and T-tau (AUC?=?0.746, P?=?0.004), while P-tau181P/T-tau (AUC?=?0.958) significantly improved the differentiation between AD and Creutzfeldt-Jakob disease as compared to A?1-42 (AUC?=?0.688, P?=?0.004), T-tau (AUC?=?0.874, P?=?0.040), and A?1-42/P-tau181P (AUC?=?0.760, P?=?0.003). In conclusion, this study demonstrates P-tau181P is an essential component of the AD CSF biomarker panel, and combined assessment of A?1-42, T-tau, and P-tau181P renders, to present date, the highest diagnostic power to discriminate between AD and non-AD dementias. PMID:26136723

  10. Serum cleaved Tau protein and neurobehavioral battery of tests as markers of brain injury in experimental bacterial meningitis

    Microsoft Academic Search

    Jose E Irazuzta; Gabrielle de Courten-Myers; Frank P Zemlan; Marni Y. V Bekkedal; John Rossi

    2001-01-01

    Brain injury due to bacterial meningitis affects multiple areas of the brain with a heterogeneous distribution generating a challenge to assess severity. Tau proteins are microtubular binding proteins localized in the axonal compartment of neurons. Brain injury releases cleaved Tau proteins (C-tau) into the extracellular space where they are transported to the cerebral spinal fluid. We hypothesized that C-tau crosses

  11. Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future.

    PubMed

    Ariza, Manuela; Kolb, Hartmuth C; Moechars, Dieder; Rombouts, Frederik; Andrés, José Ignacio

    2015-06-11

    Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia among the elderly population. The good correlation of the density and neocortical spread of neurofibrillary tangles (NFTs) with clinical AD disease progression offers an opportunity for the early diagnosis and staging using a noninvasive imaging technique such as positron emission tomography (PET). Thus, PET imaging of NFTs not only holds promise as a diagnostic tool but also may enable the development of disease modifying therapeutics for AD. In this review, we focus on the structural diversity of tau PET tracers, the challenges related to the identification of high affinity and highly selective NFT ligands, and recent progress in the clinical development of tau PET radioligands. PMID:25671691

  12. Isomonodromic Tau-Functions from Liouville Conformal Blocks

    NASA Astrophysics Data System (ADS)

    Iorgov, N.; Lisovyy, O.; Teschner, J.

    2015-06-01

    The goal of this note is to show that the Riemann-Hilbert problem to find multivalued analytic functions with -valued monodromy on Riemann surfaces of genus zero with n punctures can be solved by taking suitable linear combinations of the conformal blocks of Liouville theory at c = 1. This implies a similar representation for the isomonodromic tau-function. In the case n = 4 we thereby get a proof of the relation between tau-functions and conformal blocks discovered in Gamayun et al. (J High Energy Phys, 10:038, 2012). We briefly discuss a possible application of our results to the study of relations between certain supersymmetric gauge theories and conformal field theory.

  13. Circumstellar Disk of HL Tau Revealed by CARMA

    Microsoft Academic Search

    Woojin Kwon; Leslie W. Looney; Lee G. Mundy

    2011-01-01

    The physical properties of circumstellar disks around T Tauri stars - the so-called proto-planetary disks as the natal place of planets - are mainly studied by millimeter\\/submillimeter wavelength continuum, which is sensitive to dust thermal emission. We present high angular resolution (0.13 arc-second) imaging results of the T Tauri star HL Tau in 1.3 and 2.7 mm continua using the

  14. Preliminary results on two-dimensional interferometry of HL Tau

    Microsoft Academic Search

    Eric V. Tollestrup; Paul M. Harvey

    1989-01-01

    Preliminary two-dimensional speckle interferometry results of HL Tau were found to be qualitatively similar to those found with one-dimensional slit scanning techniques; results consist of a resolved component (approximately 0.7 arcsec in size) and an unresolved component. Researchers are currently reducing the rest of the data (taken on three different telescopes and at three different wavelengths) and are also exploring

  15. HL Tau: 3-D Polarisation Modelling and Magnetic Field Structure

    Microsoft Academic Search

    P. W. Lucas; M. Fukagawa; M. Tamura; A. Chrysostomou; A. F. Beckford

    2005-01-01

    We describe 3-dimensional Monte Carlo modelling of HL Tau in the near infrared with aligned non-spherical grains. JHK linear polarimetry with 0.4-0.6 arcsec resolution from Subaru and UKIRT is fitted in detail, providing information about the structure of the system, the grain properties and perhaps also the magnetic field. Circular polarisation models are also presented, showing how near infrared circular

  16. Numerical simulations of the GG Tau Circumbinary disk

    NASA Astrophysics Data System (ADS)

    Pierens, A.; Dutrey, A.; Guilloteau, S.; Huré, J.-M.

    2005-12-01

    We present the first 2D hydrodynamical simulations of the GG Tau circumbinary disk including self-gravity. These simulations match on many points the physical properties deduced from observations. We show that self-gravity is probably very important for the dynamical evolution of the system. In particular, we find that self-gravity noticeably affects the structure of the disk, the accretion rate onto the central binary and the orbital evolution of the binary.

  17. Deuterated molecules in DM Tau: DCO+, but no HDO

    E-print Network

    Stéphane Guilloteau; Vincent Piétu; Anne Dutrey; Michel Guélin

    2006-02-17

    We report the detection of the J=2-1 line of DCO+ in the proto-planetary disk of DM Tau and re-analyze the spectrum covering the 465 GHz transition of HDO in this source, recently published by Ceccarelli et al. (2005). A modelling of the DCO+ line profile with the source parameters derived from high resolution HCO+ observations yields a DCO+/HCO+ abundance ratio of about 0.004, an order of magnitude smaller than that derived in the low mass cores. The re-analysis of the 465 GHz spectrum, using the proper continuum flux (0.5 Jy) and source systemic velocity (6.05 km/s), makes it clear that the absorption features attributed to HDO and C6H are almost certainly unrelated to these species. We show that the line-to-continuum ratio of an absorption line in front of a Keplerian disk can hardly exceed the ratio of the turbulent velocity to the projected rotation velocity at the disk edge, unless the line is optically very thick (tau > 10 000). This ratio is typically 0.1-0.3 in proto-planetary disks and is about 0.15 in DM Tau, much smaller than that for the alleged absorption features. We also show that the detection of H2D+ in DM Tau, previously reported by these authors, is only a 2-sigma detection when the proper velocity is adopted. So far, DCO+ is thus the only deuterated molecule clearly detected in proto-planetary disks.

  18. Lightest Nuclei in UHECR versus Tau Neutrino Astronomy

    NASA Astrophysics Data System (ADS)

    Fargion, D.; D'Armiento, D.; Paggi, P.; Patri', S.

    2009-05-01

    UHECR may be either nucleons [Abraham J. et al., (Pierre Auger Collaboration), Science, vol.318, p.939-943 (arXiv:0711.2256)] or nuclei; in the latter case the Lightest Nuclei, as He or He, Li, Be, explains at best the absence of Virgo signals and the crowding of events around Cen-A bent by galactic magnetic fields [Fargion D., Phys. Scr. 78 (2008) 045901, 1-4]. This model fit the observed nuclear mass composition discovered in AUGER. However UHECR nucleons above GZK produce EeV neutrinos while Heavy Nuclei, as Fe UHECR do not produce much. UHECR He nuclei at few 1019eV suffer nuclear fragmentation (producing low energetic neutrino at tens PeVs) but it suffer anyway photo-pion GZK suppression (leading to EeV neutrinos) once above one-few 1020eV. Both these cosmogenic UHE secondary neutrinos signals may influence usual predicted GZK [Greisen K., 1966 Phys. Rev. Lett. 16 748], [Zatsepin, G.T., Kuz'min, V.A., Zh. Eks. Teor. Fiz., Pis'ma Red.4(1966) 144] Tau Neutrino Astronomy [D. Fargion, et al.: “Horizontal Tau air showers from mountains in deep valley. Traces of UHECR neutrino tau” 26th ICRC, He 6.1.09, p.396-398. 1999. (USA); Fargion D., 2002, ApJ, 570, 909; Fargion D. et al. 1999, 26th ICRC, HE6.1.10, 396-398; Fargion D., et al. 2004, ApJ, 613, 1285; Fargion D. et al., Nuclear Physics B (Proc. Suppl.) 2004; Fargion D., et al. Adv. in Space Res., 37 (2006) 2132-2138; 136, 119; D. Fargion, J. Phys. Soc. Jpn. Vol.77 (2008) Suppl. B., p.1-15; Fargion D. et al. Adv. Space Res. 37 (2006) 2132-2138] in significant and detectable way; the role of resonant antineutrino electron-electron leading to Tau air-shower may also rise.

  19. NICMOS Imaging of the GG Tau Circumbinary Disk

    NASA Astrophysics Data System (ADS)

    McCabe, C.; Ghez, A. M.

    1999-12-01

    We present deep, high spatial resolution NICMOS/HST observations of the pre-main-sequence multiple star system, GG Tau, in three broad-band filters centered at 1.1, 1.6 and 2.0 micron. The images reveal a large ring surrounding the 0."25 binary, GG Tau A, which was originally detected in ground-based observations. The circumbinary disk, which extends from a radius of 125 to 300 AU (0."9 to 2."2) is detected with a signal-to-noise ratio approximately 100 times that of the ground-based measurements and has allowed us to study in detail both its unusual integrated colors and small scale structure. Although the disk is brighter on one side than the other, which can be accounted for in terms of forward and backward scattering, the disk has a red (1.6-2.0) color excess, which is unexpected for scattered light. A color-magnitude diagram for different resolution elements over the disk show that while extinction is present, this process alone cannot account for the observed red excess. We will discuss these and other results from the GG Tau NICMOS observations.

  20. Avoiding negative populations in explicit Poisson tau-leaping

    NASA Astrophysics Data System (ADS)

    Cao, Yang; Gillespie, Daniel T.; Petzold, Linda R.

    2005-08-01

    The explicit tau-leaping procedure attempts to speed up the stochastic simulation of a chemically reacting system by approximating the number of firings of each reaction channel during a chosen time increment ? as a Poisson random variable. Since the Poisson random variable can have arbitrarily large sample values, there is always the possibility that this procedure will cause one or more reaction channels to fire so many times during ? that the population of some reactant species will be driven negative. Two recent papers have shown how that unacceptable occurrence can be avoided by replacing the Poisson random variables with binomial random variables, whose values are naturally bounded. This paper describes a modified Poisson tau-leaping procedure that also avoids negative populations, but is easier to implement than the binomial procedure. The new Poisson procedure also introduces a second control parameter, whose value essentially dials the procedure from the original Poisson tau-leaping at one extreme to the exact stochastic simulation algorithm at the other; therefore, the modified Poisson procedure will generally be more accurate than the original Poisson procedure.

  1. Line and continuum radiative transfer modelling of AA Tau

    NASA Astrophysics Data System (ADS)

    Esau, Claire F.; Harries, Tim J.; Bouvier, Jerome

    2014-09-01

    We present photometric and spectroscopic models of the Classical T Tauri star AA Tau. Photometric and spectroscopic variability present in observations of AA Tau is attributed to a magnetically induced warp in the accretion disc, periodically occulting the photosphere on an 8.2 d time-scale. Emission line profiles show signatures of both infall, attributed to magnetospherically accreting material, and outflow. Using the radiative transfer code TORUS, we have investigated the geometry and kinematics of AA Tau's circumstellar disc and outflow, which is modelled here as a disc wind. Photometric models have been used to constrain the aspect ratio of the disc, the offset angle of the magnetosphere dipole with respect to the stellar rotation axis, and the inner radius of the circumstellar disc. Spectroscopic models have been used to constrain the wind and magnetosphere temperatures, wind acceleration parameter, and mass-loss rate. We find that observations are best fitted by models with a mass accretion rate of 5 × 10-9 M? yr-1, a dipole offset of between 10° and 20°, a magnetosphere that truncates the disc from 5.2 to 8.8R?, a mass-loss-rate to accretion-rate ratio of ˜0.1, a magnetosphere temperature of 8500-9000 K, and a disc-wind temperature of 8000 K.

  2. Tau-targeted treatment strategies in Alzheimer's disease

    PubMed Central

    Götz, Jürgen; Ittner, Arne; Ittner, Lars M

    2012-01-01

    With populations ageing worldwide, the need for treating and preventing diseases associated with high age is pertinent. Alzheimer's disease (AD) is reaching epidemic proportions, yet the currently available therapies are limited to a symptomatic relief, without halting the degenerative process that characterizes the AD brain. As in AD cholinergic neurons are lost at high numbers, the initial strategies were limited to the development of acetylcholinesterase inhibitors, and more recently the NMDA receptor antagonist memantine, in counteracting excitotoxicity. With the identification of the protein tau in intracellular neurofibrillary tangles and of the peptide amyloid-? (A?) in extracellular amyloid plaques in the AD brain, and a better understanding of their role in disease, newer strategies are emerging, which aim at either preventing their formation and deposition or at accelerating their clearance. Interestingly, what is well established to combat viral diseases in peripheral organs – vaccination – seems to work for the brain as well. Accordingly, immunization strategies targeting A? show efficacy in mice and to some degree also in humans. Even more surprising is the finding in mice that immunization strategies targeting tau, a protein that forms aggregates in nerve cells, ameliorates the tau-associated pathology. We are reviewing the literature and discuss what can be expected regarding the translation into clinical practice and how the findings can be extended to other neurodegenerative diseases with protein aggregation in brain. PMID:22044248

  3. Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

    PubMed Central

    Metcalfe, Maria Jose; Figueiredo-Pereira, Maria E.

    2010-01-01

    Alzheimer's disease is a chronic, age-related neurodegenerative disorder. Neurofibrillary tangles are among the pathological hallmarks of Alzheimer's disease. Neurofibrillary tangles consist of abnormal protein fibers known as paired helical filaments. The accumulation of paired helical filaments is one of the most characteristic cellular changes in Alzheimer's disease. Tau protein, a microtubule-associated protein, is the major component of paired helical filaments. Tau in paired helical filaments is hyperphosphorylated, truncated, and aggregated. What triggers the formation of paired helical filaments is not known, but neuroinflammation could play a role. Neuroinflammation is an active process detectable in the earliest stages of Alzheimer's disease. The neuronal toxicity associated with inflammation makes it a potential risk factor in the pathogenesis of Alzheimer's disease. Determining the sequence of events that lead to this devastating disease has become one of the most important goals for the prevention and treatment of Alzheimer's disease. In this review, we focus on the pathological properties of tau thought to play a role in neurofibrillary tangle formation and summarize how central nervous system inflammation might be a critical contributor to the pathology of Alzheimer's disease. A better understanding of the mechanisms that cause neurofibrillary tangle formation is of clinical importance for developing therapeutic strategies to prevent and treat Alzheimer's disease. One of the major challenges facing us is singling out neuroinflammation as a therapeutic target for the prevention of Alzheimer's disease neurodegeneration. The challenge is developing therapeutic strategies that prevent neurotoxicity linked to inflammation without compromising its neuroprotective role. PMID:20101714

  4. Aluminum modifies the properties of Alzheimer's disease PHF tau proteins in vivo and in vitro.

    PubMed

    Shin, R W; Lee, V M; Trojanowski, J Q

    1994-11-01

    Hyperphosphorylated adult human CNS tau (PHF tau or A68) forms paired helical filaments (PHFs) in neurofibrillary tangles (NFTs), neuropil threads, and dystrophic neurites associated with senile plaques (SPs) during the progression of Alzheimer's disease (AD). While amyloid fibrils in SPs are composed of beta-amyloid (A beta), NFTs and SPs contain similar associated components such as ubiquitin, alpha 1-antichymotrypsin (ACT), apolipoprotein E (ApoE), heparan sulfate proteoglycans (HSPGs), and aluminum salts. Thus, SPs and NFTs may result from specific interactions between PHF tau, A beta, and these other components. In fact, intracerebral injections of PHF tau induce co-deposits of A beta, ACT, and ubiquitin (Shin et al., 1993). To examine this issue further, we probed interactions between PHF tau, aluminum salts, and other plaque and tangle components. We investigated in vivo interactions of PHF tau and aluminum chloride (AlCl3) with other plaque and tangle components by injecting PHF tau with and without AlCl3 into the rodent brain. PHF tau co-injected with AlCl3 formed aggregates that persisted much longer in the rat brain, and induced longer-lived co-deposits of A beta, ubiquitin, ACT, and ApoE than PHF tau alone. Injections of PHF tau with AlCl3 also induced neurons near the injection site to acquire PHF tau-like properties as monitored with antibodies (AT8, T3P, PHF1) that recognize defined PHF tau epitopes containing phosphoserine residues (Ser202, Ser396, Ser404). Injections of AlCl3 alone as well as injections of normal adult and fetal CNS tau, several different synthetic peptides, neurofilament proteins, ACT, HSPGs, or ApoE with and without AlCl3 failed to induce co-deposits of A beta or alter the immunoreactivity of tau in rodent neurons. To determine if aluminum salts interact directly and specifically with PHF tau in situ, we pretreated sections of AD hippocampus with 10 mM AlCl3 and then probed these sections by immunohistochemistry with antibodies to PHF tau as well as to a number of other plaque and tangle components. Preincubation of these sections with AlCl3 diminished PHF tau immunoreactivity in NFTs and SPs using the PHF tau-specific antibodies AT8, T3P, and PHF1, while the immunoreactivity of other plaque and tangle proteins (A beta, ubiquitin, ACT, HSPGs, ApoE) was not abolished. We also examined the effects of AlCl3 on PHF tau and normal adult human CNS tau in vitro. AlCl3 had no effect on normal adult human CNS tau, while increasing concentrations of AlCl3 (from 0.1 to 1.0 mM) induced PHF tau to aggregate at the top of the stacking gel, and at high concentrations (0.3 and 1.0 mM) of AlCl3, PHF tau completely failed to enter the gel. These studies suggest that aluminum binds to PHF tau, induces these proteins to aggregate, and retards their proteolysis. Further, since intracerebral injections of PHF tau with and without AlCl3 in rats appear uniquely capable of inducing co-deposits of a number of proteins found in authentic AD SPs and NFTs (including A beta, ubiquitin, ACT, and ApoE), we speculate that the contributions of PHF tau to plaque and tangle formation in AD may be modulated by aluminum. PMID:7525898

  5. Is a massive tau neutrino just what cold dark matter needs?

    NASA Technical Reports Server (NTRS)

    Dodelson, Scott; Gyuk, Geza; Turner, Michael S.

    1994-01-01

    The cold dark matter (CDM) scenario for structure formation in the Universe is very attractive and has many successes; however, when its spectrum of density perturbations is normalized to the COBE anisotropy measurement the level of inhomogeneity predicted on small scales is too large. This can be remedied by a tau neutrino of mass 1 MeV - 10MeV and lifetime 0.1 sec - 100 sec whose decay products include electron neutrinos because it allows the total energy density in relativistic particles to be doubled without interfering with nucleosynthesis. The anisotropies predicted on the degree scale for 'tau CDM' are larger than standard CDM. Experiments at e(sup +/-) collides may be able to probe such a mass range.

  6. Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in Aggresomes*

    PubMed Central

    Santa-Maria, Ismael; Varghese, Merina; Ksi??ak-Reding, Hanna; Dzhun, Anastasiya; Wang, Jun; Pasinetti, Giulio M.

    2012-01-01

    Abnormal folding of tau protein leads to the generation of paired helical filaments (PHFs) and neurofibrillary tangles, a key neuropathological feature in Alzheimer disease and tauopathies. A specific anatomical pattern of pathological changes developing in the brain suggests that once tau pathology is initiated it propagates between neighboring neuronal cells, possibly spreading along the axonal network. We studied whether PHFs released from degenerating neurons could be taken up by surrounding cells and promote spreading of tau pathology. Neuronal and non-neuronal cells overexpressing green fluorescent protein-tagged tau (GFP-Tau) were treated with isolated fractions of human Alzheimer disease-derived PHFs for 24 h. We found that cells internalized PHFs through an endocytic mechanism and developed intracellular GFP-Tau aggregates with attributes of aggresomes. This was particularly evident by the perinuclear localization of aggregates and redistribution of the vimentin intermediate filament network and retrograde motor protein dynein. Furthermore, the content of Sarkosyl-insoluble tau, a measure of abnormal tau aggregation, increased 3-fold in PHF-treated cells. An exosome-related mechanism did not appear to be involved in the release of GFP-Tau from untreated cells. The evidence that cells can internalize PHFs, leading to formation of aggresome-like bodies, opens new therapeutic avenues to prevent propagation and spreading of tau pathology. PMID:22496370

  7. Tau binding to microtubules does not directly affect microtubule-based vesicle motility.

    PubMed

    Morfini, Gerardo; Pigino, Gustavo; Mizuno, Naoko; Kikkawa, Masahide; Brady, Scott T

    2007-09-01

    Tau protein is a major microtubule (MT)-associated brain protein enriched in axons. Multiple functional roles are proposed for tau protein, including MT stabilization, generation of cell processes, and targeting of phosphotransferases to MTs. Recently, experiments involving exogenous tau expression in cultured cells suggested a role for tau as a regulator of kinesin-1-based motility. Tau was proposed to inhibit attachment of kinesin-1 to MTs by competing for the kinesin-1 binding site. In this work, we evaluated effects of tau on fast axonal transport (FAT) by using vesicle motility assays in isolated squid axoplasm. Effects of recombinant tau constructs on both kinesin-1 and cytoplasmic dynein-dependent FAT rates were evaluated by video microscopy. Exogenous tau binding to endogenous squid MTs was evidenced by a dramatic change in individual MT morphologies. However, perfusion of tau at concentrations approximately 20-fold higher than physiological levels showed no effect on FAT. In contrast, perfusion of a cytoplasmic dynein-derived peptide that competes with kinesin-1 and cytoplasmic dynein binding to MTs in vitro rapidly inhibited FAT in both directions. Taken together, our results indicate that binding of tau to MTs does not directly affect kinesin-1- or cytoplasmic dynein-based motilities. In contrast, our results provide further evidence indicating that the functional binding sites for kinesin-1 and cytoplasmic dynein on MTs overlap. PMID:17265463

  8. Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons.

    PubMed

    Stoothoff, William H; Bacskai, Brian J; Hyman, Bradley T

    2008-01-01

    Tau is a microtubule associated protein that is localized to the axon in neurons. During pathological conditions, including frontotemporal dementia (FTD), a shift in tau isoforms occurs that leads to enhanced expression of a form of tau with four (rather than three) microtubule binding repeats; this has been postulated to alter microtubule structure. Second harmonic generation (SHG) is a technique that allows the visualization of intact microtubules in axons of living neurons without the need for labeling or fixing. We examined how the presence of exogenous tau influences SHG in living neurons. Our results show that the presence of tau significantly enhances SHG, specifically in neuronal axons, despite the presence of tau throughout the entire cell. Our data also suggest that the presence or absence of the fourth microtubule binding repeat does not significantly alter tau's ability to enhance SHG. These results provide evidence that SHG is a useful, noninvasive tool to study tau-microtubule interactions in axons; further, it appears that tau overexpression, rather than specific isoforms, is the major contributor to tau-induced changes in axonal microtubule SHG signal. PMID:19123685

  9. Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.

    PubMed

    Mirbaha, Hilda; Holmes, Brandon B; Sanders, David W; Bieschke, Jan; Diamond, Marc I

    2015-06-12

    Tau amyloid assemblies propagate aggregation from the outside to the inside of a cell, which may mediate progression of the tauopathies. The critical size of Tau assemblies, or "seeds," responsible for this activity is currently unknown, but this could be important for the design of effective therapies. We studied recombinant Tau repeat domain (RD) and Tau assemblies purified from Alzheimer disease (AD) brain composed largely of full-length Tau. Large RD fibrils were first sonicated to create a range of assembly sizes. We confirmed our ability to resolve stable assemblies ranging from n = 1 to >100 units of Tau using size exclusion chromatography, fluorescence correlation spectroscopy, cross-linking followed by Western blot, and mass spectrometry. All recombinant Tau assemblies bound heparan sulfate proteoglycans on the cell surface, which are required for Tau uptake and seeding, because they were equivalently sensitive to inhibition by heparin and chlorate. However, cells only internalized RD assemblies of n ? 3 units. We next analyzed Tau assemblies from AD or control brains. AD brains contained aggregated species, whereas normal brains had predominantly monomer, and no evidence of large assemblies. HEK293 cells and primary neurons spontaneously internalized Tau of n ? 3 units from AD brain in a heparin- and chlorate-sensitive manner. Only n ? 3-unit assemblies from AD brain spontaneously seeded intracellular Tau aggregation in HEK293 cells. These results indicate that a clear minimum size (n = 3) of Tau seed exists for spontaneous propagation of Tau aggregation from the outside to the inside of a cell, whereas many larger sizes of soluble aggregates trigger uptake and seeding. PMID:25887395

  10. The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian Hibernation

    PubMed Central

    Stieler, Jens T.; Bullmann, Torsten; Kohl, Franziska; Tøien, Øivind; Brückner, Martina K.; Härtig, Wolfgang; Barnes, Brian M.; Arendt, Thomas

    2011-01-01

    Abnormal phosphorylation and aggregation of tau protein are hallmarks of a variety of neurological disorders, including Alzheimer's disease (AD). Increased tau phosphorylation is assumed to represent an early event in pathogenesis and a pivotal aspect for aggregation and formation of neurofibrillary tangles. However, the regulation of tau phosphorylation in vivo and the causes for its increased stage of phosphorylation in AD are still not well understood, a fact that is primarily based on the lack of adequate animal models. Recently we described the reversible formation of highly phosphorylated tau protein in hibernating European ground squirrels. Hence, mammalian hibernation represents a model system very well suited to study molecular mechanisms of both tau phosphorylation and dephosphorylation under in vivo physiological conditions. Here, we analysed the extent and kinetics of hibernation-state dependent tau phosphorylation in various brain regions of three species of hibernating mammals: arctic ground squirrels, Syrian hamsters and black bears. Overall, tau protein was highly phosphorylated in torpor states and phosphorylation levels decreased after arousal in all species. Differences between brain regions, hibernation-states and phosphosites were observed with respect to degree and kinetics of tau phosphorylation. Furthermore, we tested the phosphate net turnover of tau protein to analyse potential alterations in kinase and/or phosphatase activities during hibernation. Our results demonstrate that the hibernation-state dependent phosphorylation of tau protein is specifically regulated but involves, in addition, passive, temperature driven regulatory mechanisms. By determining the activity-state profile for key enzymes of tau phosphorylation we could identify kinases potentially involved in the differentially regulated, reversible tau phosphorylation that occurs during hibernation. We show that in black bears hibernation is associated with conformational changes of highly phosphorylated tau protein that are typically related to neuropathological alterations. The particular hibernation characteristics of black bears with a continuous torpor period and an only slightly decreased body temperature, therefore, potentially reflects the limitations of this adaptive reaction pattern and, thus, might indicate a transitional state of a physiological process. PMID:21267079

  11. Reversible heat stress-related loss of phosphorylated Alzheimer-type epitopes in Tau proteins of human neuroblastoma cells.

    PubMed

    Chiang, M F; Liu, W K; Yen, S H

    1993-11-01

    Human neuroblastoma cells, LAN, were used to study the phosphorylation and dephosphorylation of tau proteins. These cells contained mainly a form of tau comparable to fetal brain tau in molecular weight (55 kDa). Neuroblastoma tau reacted with antibodies that recognize epitopes spanning the whole tau molecule (E-1, Alz50, Tau-1, and Tau46), and antibodies (PHF-1, NP8, and T3P) that recognize hyperphosphorylated tau (PHF-tau) in Alzheimer's disease (AD) brains. Exposure of the cells to 45 degrees C heat stress resulted in dephosphorylation of the epitopes recognized by PHF-1, NP8, and T3P. Transfer of the heat-stressed cells to 37 degrees C led to rephosphorylation of the dephosphorylated epitopes. Cells that had been treated with okadaic acid (OA), regardless of whether they were subsequently subjected to heat stress or heat stress and recovery, all contained tau with a molecular weight similar to that of control cells. These tau proteins, similar to tau in control cells, also reacted with antibodies to phosphorylated epitopes. However, unlike the tau from control or heat-stressed cells, the OA-treated and heat-stressed tau had decreased reactivity with Tau-1. Alteration of Tau-1 immunoreactivity has been reported to be an early event in AD neurodegeneration. The reduction of Tau-1 immunoreactivity observed in OA-treated samples could be restored by incubation of electroblots of isolated tau with alkaline phosphatase, indicating an induction of the Tau-1 epitope phosphorylation by OA.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7693894

  12. Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3{zeta} protein

    SciTech Connect

    Sadik, Golam [Department of Psychiatry, Graduate School of Medicine, Osaka University, D3, 2-2, Yamadaoka, Suita, Osaka 565-0871 (Japan)] [Department of Psychiatry, Graduate School of Medicine, Osaka University, D3, 2-2, Yamadaoka, Suita, Osaka 565-0871 (Japan); Tanaka, Toshihisa, E-mail: tanaka@psy.med.osaka-u.ac.jp [Department of Psychiatry, Graduate School of Medicine, Osaka University, D3, 2-2, Yamadaoka, Suita, Osaka 565-0871 (Japan)] [Department of Psychiatry, Graduate School of Medicine, Osaka University, D3, 2-2, Yamadaoka, Suita, Osaka 565-0871 (Japan); Kato, Kiyoko; Yanagi, Kentaro; Kudo, Takashi; Takeda, Masatoshi [Department of Psychiatry, Graduate School of Medicine, Osaka University, D3, 2-2, Yamadaoka, Suita, Osaka 565-0871 (Japan)] [Department of Psychiatry, Graduate School of Medicine, Osaka University, D3, 2-2, Yamadaoka, Suita, Osaka 565-0871 (Japan)

    2009-05-22

    Tau isoforms, 3-repeat (3R) and 4-repeat tau (4R), are differentially involved in neuronal development and in several tauopathies. 14-3-3 protein binds to tau and 14-3-3/tau association has been found both in the development and in tauopathies. To understand the role of 14-3-3 in the differential regulation of tau isoforms, we have performed studies on the interaction and aggregation of 3R-tau and 4R-tau, either phosphorylated or unphosphorylated, with 14-3-3{zeta}. We show by surface plasmon resonance studies that the interaction between unphosphorylated 3R-tau and 14-3-3{zeta} is {approx}3-folds higher than that between unphosphorylated 4R-tau and 14-3-3{zeta}. Phosphorylation of tau by protein kinase A (PKA) increases the affinity of both 3R- and 4R-tau for 14-3-3{zeta} to a similar level. An in vitro aggregation assay employing both transmission electron microscopy and fluorescence spectroscopy revealed the aggregation of unphosphorylated 4R-tau to be significantly higher than that of unphosphorylated 3R-tau following the induction of 14-3-3{zeta}. The filaments formed from 3R- and 4R-tau were almost similar in morphology. In contrast, the aggregation of both 3R- and 4R-tau was reduced to a similar low level after phosphorylation with PKA. Taken together, these results suggest that 14-3-3{zeta} exhibits a similar role for tau isoforms after PKA-phosphorylation, but a differential role for unphosphorylated tau. The significant aggregation of 4R-tau by 14-3-3{zeta} suggests that 14-3-3 may act as an inducer in the generation of 4R-tau-predominant neurofibrillary tangles in tauopathies.

  13. Single Mutations in Tau Modulate the Populations of Fibril Conformers through Seed Selection

    PubMed Central

    Meyer, Virginia; Dinkel, Paul D.; Luo, Yin; Yu, Xiang; Wei, Guanghong; Zheng, Jie; Eaton, Gareth R.; Ma, Buyong; Nussinov, Ruth; Eaton, Sandra S.; Margittai, Martin

    2014-01-01

    Seeded conversion of tau monomers into fibrils is a central step in the progression of tau pathology in Alzheimer’s disease and other neurodegenerative disorders. Self-assembly is mediated by the microtubule binding repeats in tau of which either three or four are present, depending on the protein isoform. Here we used double electron-electron resonance spectroscopy to investigate the conformational ensemble of four-repeat tau fibrils. We observe that single point mutations at key positions in the protein (?K280, P301S, P312I, D314I) markedly change the distribution of fibril conformers after template-assisted growth, whereas other mutations in the protein (I308M, S320F, G323I, G326I, Q336R) do not. These findings provide unprecedented insights into the seed selection of tau disease mutants and establish conformational compatibility as an important driving force in tau fibril propagation. PMID:24453187

  14. The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease

    PubMed Central

    Liu, Zhenzhen; Li, Tao; Li, Ping; Wei, Nannan; Zhao, Zhiquan; Liang, Huimin; Ji, Xinying; Chen, Wenwu; Xue, Mengzhou; Wei, Jianshe

    2015-01-01

    Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks of AD are amyloid plaques [aggregates of amyloid-beta (A?)] and neurofibrillary tangles (aggregates of tau). Growing evidence suggests that tau accumulation is pathologically more relevant to the development of neurodegeneration and cognitive decline in AD patients than A? plaques. Oxidative stress is a prominent early event in the pathogenesis of AD and is therefore believed to contribute to tau hyperphosphorylation. Several studies have shown that the autophagic pathway in neurons is important under physiological and pathological conditions. Therefore, this pathway plays a crucial role for the degradation of endogenous soluble tau. However, the relationship between oxidative stress, tau protein hyperphosphorylation, autophagy dysregulation, and neuronal cell death in AD remains unclear. Here, we review the latest progress in AD, with a special emphasis on oxidative stress, tau hyperphosphorylation, and autophagy. We also discuss the relationship of these three factors in AD.

  15. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3?.

    PubMed

    Wang, Xiu-Lian; Zeng, Ji; Yang, Yang; Xiong, Yan; Zhang, Zhi-Hua; Qiu, Mei; Yan, Xiong; Sun, Xu-Ying; Tuo, Qing-Zhang; Liu, Rong; Wang, Jian-Zhi

    2015-01-01

    Abnormal hyperphosphorylation of microtubule-associated protein tau is involved in the pathogenesis of several neurodegenerative disorders including Alzheimer's disease (AD). Helicobacter pylori (H. pylori) infection has been reported to be related with a high risk of AD, but the direct laboratory evidence is lacking. Here we explored the effect of H. pylori infection on tau phosphorylation. The results showed that H. pylori filtrate induced significant tau hyperphosphorylation at several AD-related tau phosphorylation sites, such as Thr205, Thr231, and Ser404, both in mouse neuroblastoma N2a cells and rat brains with activation of glycogen synthase kinase-3? (GSK-3?). Application of GSK-3 inhibitors efficiently attenuated the H. pylori-induced tau hyperphosphorylation. Our data provide evidence supporting the role of H. pylori infection in AD-like tau pathology, suggesting that H. pylori eradication may be beneficial in the prevention of tauopathy. PMID:25079798

  16. OBSERVATIONAL SEARCH FOR PeV-EeV TAU NEUTRINO FROM GRB081203A

    SciTech Connect

    Aita, Y.; Aoki, T.; Asaoka, Y.; Chonan, T.; Jobashi, M.; Masuda, M.; Morimoto, Y.; Noda, K.; Sasaki, M. [Institute for Cosmic Ray Research, University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Asoh, J.; Ishikawa, N.; Ogawa, S. [Department of Physics, Toho University, Funabashi, Chiba 274-8510 (Japan); Learned, J. G.; Matsuno, S.; Olsen, S. [Department of Physics and Astronomy, University of Hawaii at Manoa, Honolulu, HI 96822 (United States); Binder, P.-M.; Hamilton, J. [Department of Physics and Astronomy, University of Hawaii at Hilo, Hilo, HI 96720-4091 (United States); Sugiyama, N. [Department of Physics and Astrophysics, Nagoya University, Nagoya, Aichi 464-8601 (Japan); Watanabe, Y., E-mail: asaoka@icrr.u-tokyo.ac.jp, E-mail: sasakim@icrr.u-tokyo.ac.jp [Department of Engineering, Kanagawa University, Yokohama, Kanagawa 221-8686 (Japan)

    2011-07-20

    We report the first observational search for tau neutrinos ({nu}{sub {tau}}) from gamma-ray bursts (GRBs) using one of the Ashra light collectors. The Earth-skimming {nu}{sub {tau}} technique of imaging Cherenkov {tau} showers was applied as a detection method. We set stringent upper limits on the {nu}{sub {tau}} fluence in PeV-EeV region for 3780 s (between 2.83 and 1.78 hr before) and another 3780 s (between 21.2 and 22.2 hr after) surrounding GRB081203A triggered by the Swift satellite. This first search for PeV-EeV {nu}{sub {tau}} complements other experiments in energy range and methodology, and suggests the prologue of 'multi-particle astronomy' with a precise determination of time and location.

  17. Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy.

    PubMed Central

    Pérez, M.; Valpuesta, J. M.; de Garcini, E. M.; Quintana, C.; Arrasate, M.; López Carrascosa, J. L.; Rábano, A.; García de Yébenes, J.; Avila, J.

    1998-01-01

    Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 6 PMID:9626057

  18. Relationship of Adult Neurogenesis with Tau Phosphorylation and GSK-3? Activity in Subventricular Zone

    Microsoft Academic Search

    Xiao-Ping HongCai-Xia; Cai-Xia Peng; Wei Wei; Qing Tian; Ying-Hua Liu; Fu-Yuan Cao; Qun Wang; Jian-Zhi Wang

    2011-01-01

    Altered neurogenesis has been reported in Alzheimer disease (AD), the most common neurodegenerative disorder characterized\\u000a with hyperphosphorylated tau and accumulation of ?-amyloid (A?). Recent studies suggest that tau phosphorylation is essential\\u000a for hippocampal neurogenesis, however, it is not known whether tau phosphorylation also play a role in neurogenesis of subventricular\\u000a zone (SVZ), another main progenitor niche in the brain. Here,

  19. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

    Microsoft Academic Search

    K. Stamer; R. Vogel; E. Thies; E. Mandelkow

    2002-01-01

    e studied the effect of microtubule-associated tau protein on trafficking of vesicles and organelles in primary cortical neurons, retinal ganglion cells, and neuroblastoma cells. Tau inhibits kinesin-dependent transport of peroxisomes, neurofilaments, and Golgi-derived vesicles into neurites. Loss of peroxisomes makes cells vulnerable to oxidative stress and leads to degeneration. In particular, tau inhibits transport of amyloid precursor protein (APP) into

  20. Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies

    Microsoft Academic Search

    Pankajavalli Ramakrishnan; Dennis W Dickson; Peter Davies

    2003-01-01

    Pin1, a peptidyl-prolyl isomerase binds to mitotic serine or threonine phosphoproteins. In Alzheimer's disease (AD) evidence points to the reactivation of mitosis in vulnerable neurons. Tangles composed of hyperphosphorylated tau contain phosphorylated Thr231 (pThr231 tau), which occurs to a greater extent in the AD brain than in the normal brain, and Pin1 has been shown to bind pThr231 tau. Here,

  1. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau

    PubMed Central

    Abisambra, Jose; Jinwal, Umesh K.; Miyata, Yoshinari; Rogers, Justin; Blair, Laura; Li, Xiaokai; Seguin, Sandlin P.; Wang, Li; Jin, Ying; Bacon, Justin; Brady, Sarah; Cockman, Matthew; Guidi, Chantal; Zhang, Juan; Koren, John; Young, Zapporah T.; Atkins, Christopher A.; Zhang, Bo; Lawson, Lisa Y.; Weeber, Edwin J.; Brodsky, Jeffrey L.; Gestwicki, Jason E.; Dickey, Chad A.

    2013-01-01

    Background The microtubule associated protein tau accumulates in neurodegenerative diseases known as tauopathies, the most common being Alzheimer’s disease (AD). One way to treat these disorders may be to reduce abnormal tau levels through chaperone manipulation, thus subverting synaptic plasticity defects caused by tau’s toxic accretion. Methods Tauopathy models were used to study the impact of YM-01 on tau. YM-01 is an allosteric promoter of triage functions of the most abundant variant of the Hsp70 family in the brain, Hsc70. The mechanisms by which YM-01 modified Hsc70 activity and tau stability were evaluated with biochemical methods, cell cultures and primary neuronal cultures from tau transgenic mice. YM-01 was also administered to acute brain slices of tau mice; changes in tau stability and electrophysiological correlates of learning and memory were measured. Results Tau levels were rapidly and potently reduced in vitro and ex vivo upon treatment with nanomolar concentrations of YM-01. Consistent with Hsc70 having a key role in this process, over-expression of Hsp40 (DNAJB2), an Hsp70 co-chaperone, suppressed YM-01 activity. In contrast to its effects in pathogenic tauopathy models, YM-01 had little activity in ex vivo brain slices from normal, wildtype mice unless microtubules were disrupted, suggesting that Hsc70 acts preferentially on abnormal pools of free tau. Finally, treatment with YM-01 increased long-term potentiation in from tau transgenic brain slices. Conclusions Therapeutics that exploit the ability of chaperones to selectively target abnormal tau can rapidly and potently rescue the synaptic dysfunction that occurs in AD and other tauopathies. PMID:23607970

  2. Molecular mechanism of tau aggregation induced by anionic and cationic dyes.

    PubMed

    Lira-De León, Karla I; García-Gutiérrez, Ponciano; Serratos, Iris N; Palomera-Cárdenas, Marianela; Figueroa-Corona, María Del P; Campos-Peña, Victoria; Meraz-Ríos, Marco A

    2013-01-01

    Abnormal tau filaments are a hallmark of Alzheimer's disease. Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in vitro. SH-SY5Y cells were incubated with each dye for seven days leading to intracellular aggregates of tau protein, with different morphological characteristics. Interestingly, these tau aggregates were not observed when the Methylene Blue dye was added to the cell culture. In order to investigate the molecular mechanisms underlying this phenomenon, we developed a computational model for the interaction of the tau paired helical filament (PHF) core with every dye by docking analysis. The polar/electrostatic and nonpolar contribution to the free binding energy in the tau PHF core-anionic dye interaction was determined. We found that the tau PHF core can generate a positive net charge within the binding site localized at residuesLys311 and Lys340 (numbering according to the longest isoform hTau40). These residues are important for the binding affinity of the negative charges present in the anionic dyes causing an electrostatic environment that stabilizes the complex. Tau PHF core protofibril-Congo Red interaction has a stronger binding affinity compared to Thiazine Red or Thioflavin S. By contrast, the cationic dye Methylene Blue does not bind to nor stabilize the tau PHF core protofibrils. These results characterize the driving forces responsible for the binding of tau to anionic dyes leading to their self-aggregation and suggest that Methylene Blue may act as a destabilizing agent of tau aggregates. PMID:23435411

  3. Effect of 14-3-3 tau protein on differentiation in BeWo choriocarcinoma cells

    Microsoft Academic Search

    Y. Cheng; R. Hu; H. Jin; K. Ma; S. Zhou; H. Cheng; D. Ma; X. Li

    2010-01-01

    This study aimed to investigate the location and function of tau isoform of 14-3-3 proteins in human trophoblast. 14-3-3 tau was localized in human cytotrophoblast cells, but not in syncytiotrophoblast cells in both first trimester and term placenta by immunochemistry stain. Forskolin-induced cell fusion (BeWo cells) confirmed that 14-3-3 tau was decreased during trophoblast differentiation. Forskolin-induced differentiation was stimulated by

  4. Search for pair production of the scalar top quark in muon plus tau final states

    SciTech Connect

    Abazov V. M.; Abbott B.; Acharya B. S.; Adams M.; Adams T.; Alexeev G. D.; Alkhazov G.; Alton A.; Alverson G.; Aoki M.; Askew A.; Asman B.; Atkins S.; Atramentov O.; Augsten K.; Avila C.; BackusMayes J.; Badaud F.; Bagby L.; Baldin B.; Bandurin D. V.; Banerjee S.; Barberis E.; Baringer P.; Barreto J.; Bartlett J. F.; Bassler U.; Bazterra V.; Bean A.; Begalli M.; Belanger-Champagne C.; Bellantoni L.; Beri S. B.; Bernardi G.; Bernhard R.; Bertram I.; Besancon M.; Beuselinck R.; Bezzubov V. A.; Bhat P. C.; Bhatia S.; Bhatnagar V.; Blazey G.; Blessing S.; Bloom K.; Boehnlein A.; Boline D.; Boos E. E.; Borissov G.; Bose T.; Brandt A.; Brandt O.; Brock R.; Brooijmans G.; Bross A.; Brown D.; Brown J.; Bu X. B.; Buehler M.; Buescher V.; Bunichev V.; Burdin S.; Burnett T. H.; Buszello C. P.; Calpas B.; Camacho-Perez E.; Carrasco-Lizarraga M. A.; Casey B. C. K.; Castilla-Valdez H.; Chakrabarti S.; Chakraborty D.; Chan K. M.; Chandra A.; Chapon E.; Chen G.; Chevalier-Thery S.; Cho D. K.; Cho S. W.; Choi S.; Choudhary B.; Cihangir S.; Claes D.; Clutter J.; Cooke M.; Cooper W. E.; Corcoran M.; Couderc F.; Cousinou M. -C.; Croc A.; Cutts D.; Das A.; Davies G.; de Jong S. J.; De La Cruz-Burelo E.; Deliot F.; Demina R.; Denisov D.; Denisov S. P.; Desai S.; Deterre C.; DeVaughan K.; Diehl H. T.; Diesburg M.; Ding P. F.; Dominguez A.; Dorland T.; Dubey A.; Dudko L. V.; Duggan D.; Duperrin A.; Dutt S.; Dyshkant A.; Eads M.; Edmunds D.; Ellison J.; Elvira V. D.; Enari Y.; Evans H.; Evdokimov A.; Evdokimov V. N.; Facini G.; Ferbel T.; Fiedler F.; Filthaut F.; Fisher W.; Fisk H. E.; Fortner M.; Fox H.; Fuess S.; Garcia-Bellido A.; Garcia-Guerra G. A.; Gavrilov V.; Gay P.; Geng W.; Gerbaudo D.; Gerber C. E.; Gershtein Y.; Ginther G.; Golovanov G.; Goussiou A.; Grannis P. D.; Greder S.; Greenlee H.; Greenwood Z. D.; Gregores E. M.; Grenier G.; Gris Ph.; Grivaz J. -F.; Grohsjean A.; Gruenendahl S.; Gruenewald M. W.; Guillemin T.; Gutierrez G.; Gutierrez P.; Haas A.; Hagopian S.; Haley J.; Han L.; Harder K.; Harel A.; Hauptman J. M.; Hays J.; Head T.; Hebbeker T.; Hedin D.; Hegab H.; Heinson A. P.; Heintz U.; Hensel C.; Heredia-De La Cruz I.; Herner K.; Hesketh G.; Hildreth M. D.; Hirosky R.; Hoang T.; Hobbs J. D.; Hoeneisen B.; Hohlfeld M.; Hubacek Z.; Hynek V.; Iashvili I.; Ilchenko Y.; Illingworth R.; Ito A. S.; Jabeen S.; Jaffre M.; Jamin D.; Jayasinghe A.; Jesik R.; Johns K.; Johnson M.; Jonckheere A.; Jonsson P.; Joshi J.; Jung A. W.; Juste A.; Kaadze K.; Kajfasz E.; Karmanov D.; Kasper P. A.; Katsanos I.; Kehoe R.; Kermiche S.; Khalatyan N.; Khanov A.; Kharchilava A.; Kharzheev Y. N.; Kohli J. M.; Kozelov A. V.; Kraus J.; Kulikov S.; Kumar A.; Kupco A.; Kurca T.; Kuzmin V. A.; Lammers S.; Landsberg G.; Lebrun P.; Lee H. S.; Lee S. W.; Lee W. M.; Lellouch J.; Li H.; Li L.; Li Q. Z.; Lietti S. M.; Lim J. K.; Lincoln D.; Linnemann J.; Lipaev V. V.; Lipton R.; Liu Y.; Lobodenko A.; Lokajicek M.; Lopes de Sa R.; Lubatti H. J.; Luna-Garcia R.; Lyon A. L.; Maciel A. K. A.; Mackin D.; Madar R.; Magana-Villalba R.; Malik S.; Malyshev V. L.; Maravin Y.; Martinez-Ortega J.; McCarthy R.; McGivern C. L.; Meijer M. M.; Melnitchouk A.; Menezes D.; Mercadante P. G.; Merkin M.; et al.

    2012-04-20

    We present a search for the pair production of scalar top quarks ({tilde t}{sub 1}), the lightest supersymmetric partners of the top quarks, in p{bar p} collisions at a center-of-mass energy of 1.96 TeV, using data corresponding to an integrated luminosity of 7.3 fb{sup -1} collected with the D0 experiment at the Fermilab Tevatron Collider. Each scalar top quark is assumed to decay into a b quark, a charged lepton, and a scalar neutrino ({tilde {nu}}). We investigate final states arising from {tilde t}{sub 1}{ovr {tilde t}{sub 1}} {yields} b{bar b}{mu}{tau}{tilde {nu}}{tilde {nu}} and {tilde t}{sub 1}{ovr {tilde t}{sub 1}} {yields} b{bar b}{tau}{tau}{tilde {nu}}{tilde {nu}}. With no significant excess of events observed above the background expected from the standard model, we set exclusion limits on this production process in the (M{sub {tilde t}{sub 1}}, M{sub {tilde {nu}}}) plane.

  5. Fibers of tau fragments, but not full length tau, exhibit a cross beta-structure: implications for the formation of paired helical filaments.

    PubMed Central

    Giannetti, A. M.; Lindwall, G.; Chau, M. F.; Radeke, M. J.; Feinstein, S. C.; Kohlstaedt, L. A.

    2000-01-01

    We have used X-ray fiber diffraction to probe the structure of fibers of tau and tau fragments. Fibers of fragments from the microtubule binding domain had a cross beta-structure that closely resembles that reported both for neurofibrillary tangles found in Alzheimer's disease brain and for fibrous lesions from other protein folding diseases. In contrast, fibers of full-length tau had a different, more complex structure. Despite major differences at the molecular level, all fiber types exhibited very similar morphology by electron microscopy. These results have a number of implications for understanding the etiology of Alzheimer's and other tauopathic diseases. The morphology of the peptide fibers suggests that the region in tau corresponding to the peptides plays a critical role in the nucleation of fiber assembly. The dramatically different structure of the full length tau fibers suggests that some region in tau has enough inherent structure to interfere with the formation of cross beta-fibers. Additionally, the similar appearance by electron microscopy of fibrils with varying molecular structure suggests that different molecular arrangements may exist in other samples of fibers formed from tau. PMID:11206064

  6. Test of the tau-model of Bose-Einstein correlations and reconstruction of the source function in hadronic Z-boson decay at LEP

    E-print Network

    Becker, Ulrich J.

    Bose–Einstein correlations of pairs of identical charged pions produced in hadronic Z decays are analyzed in terms of various parametrizations. A good description is achieved using a Lévy stable distribution in conjunction ...

  7. Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging

    PubMed Central

    2013-01-01

    Background Complex species-specific, developmental- and tissue-dependent mechanisms regulate alternative splicing of tau, thereby diversifying tau protein synthesis. The functional role of alternative splicing of tau e.g. exon 10 has never been examined in vivo, although genetic studies suggest that it is important to neurodegenerative disease. Results Gene-targeting was used to delete exon 10 in murine tau on both alleles (E10?/?) to study its functional role. Moreover, mice devoid of exon 10 (E10+/?) on one allele were generated to investigate the effects of 1:1 balanced expression of 4R-/3R-tau protein, since equal amounts of 4R-/3R-tau protein are synthesized in human brain. Middle-aged E10?/? mice displayed sensorimotor disturbances in the rotarod when compared to age-matched E10+/? and wild-type mice, and their muscular grip strength was less than that of E10+/? mice. The performance of E10+/? mice and wild-type mice (E10+/+) was similar in sensorimotor tests. Cognitive abilities or anxiety-like behaviours did not depend on exon 10 in tau, and neither pathological inclusions nor gene-dependent morphological abnormalities were found. Conclusion Ablation of exon 10 in the murine tau gene alters alternative splicing and tau protein synthesis which results in mild sensorimotor phenotypes with aging. Presumably related microtubule-stabilizing genes rescue other functions. PMID:24261309

  8. Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

    PubMed Central

    Santa-Maria, Ismael; Alaniz, Maria E.; Renwick, Neil; Cela, Carolina; Fulga, Tudor A.; Van Vactor, David; Tuschl, Thomas; Clark, Lorraine N.; Shelanski, Michael L.; McCabe, Brian D.; Crary, John F.

    2015-01-01

    Tau is a highly abundant and multifunctional brain protein that accumulates in neurofibrillary tangles (NFTs), most commonly in Alzheimer’s disease (AD) and primary age-related tauopathy. Recently, microRNAs (miRNAs) have been linked to neurodegeneration; however, it is not clear whether miRNA dysregulation contributes to tau neurotoxicity. Here, we determined that the highly conserved brain miRNA miR-219 is downregulated in brain tissue taken at autopsy from patients with AD and from those with severe primary age-related tauopathy. In a Drosophila model that produces human tau, reduction of miR-219 exacerbated tau toxicity, while overexpression of miR-219 partially abrogated toxic effects. Moreover, we observed a bidirectional modulation of tau levels in the Drosophila model that was dependent on miR-219 expression or neutralization, demonstrating that miR-219 regulates tau in vivo. In mammalian cellular models, we found that miR-219 binds directly to the 3?-UTR of the tau mRNA and represses tau synthesis at the post-transcriptional level. Together, our data indicate that silencing of tau by miR-219 is an ancient regulatory mechanism that may become perturbed during neurofibrillary degeneration and suggest that this regulatory pathway may be useful for developing therapeutics for tauopathies. PMID:25574843

  9. Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus.

    PubMed

    Bullmann, Torsten; de Silva, Rohan; Holzer, Max; Mori, Hiroshi; Arendt, Thomas

    2007-01-01

    Tau is a microtubule-associated protein with a developmentally regulated expression of multiple isoforms. The neonatal isoform is devoid of two amino terminal inserts and contains only three instead of four microtubule-binding repeats (0N/3R-tau). We investigated the temporal expression pattern of 0N-tau and 3R-tau in the rat hippocampus. After the decline of 0N- and 3R-tau immunoreactivity during the postnatal development both isoforms remain highly expressed in a few cells residing beneath the granule cell layer. Coexpression of the polysialylated neuronal cell adhesion molecule, doublecortin, and incorporated bromodeoxyuridine showed that these cells are proliferating progenitor cells. In contrast mature granule cells express the adult tau protein isoform containing one aminoterminal insert domain (1N-tau). Therefore a shift in tau isoform expression takes place during adult neurogenesis, which might be related to migration, differentiation, and integration in the granule cell layer. A model for studying shifts in tau isoform expression in a defined subset of neurons might help to understand the etiology of tauopathies, when isoform composition is crucial for neurodegeneration, as in Pick's disease or FTDP-17. PMID:17183532

  10. GSPE interferes with tau aggregation in vivo: implication for treating tauopathy

    PubMed Central

    Santa-Maria, Ismael; Diaz-Ruiz, Carmen; Ksiezak-Reding, Hanna; Chen, Alice; Ho, Lap; Wang, Jun; Pasinetti, Giulio Maria

    2012-01-01

    Tauopathies are characterized by progressive neurodegeneration caused by intracellular accumulation of hyperphosphorylated tau protein aggregates in the brain. The present study was designed to test whether a grape seed polyphenolic extract (GSPE) previously shown to inhibit tau protein aggregation in vitro could benefit tau-mediated neuropathology and behavior deficits in JNPL3 transgenic mice expressing a human tau protein containing the P301L mutation. Nine months old JNPL3 mice were treated with GSPE delivered through their drinking water for six months. We found that GSPE treatment significantly reduced the number of motor neurons immunoreactive for hyperphosphorylated and conformationally-modified tau in the ventral horns of the spinal cord identified using AT100, PHF-1, AT8 and Alz50 tau antibodies. This coincided with a drastically reduced level of hyperphosphorylated and sarcosyl-insoluble tau in spinal cord fractions. Furthermore, the reduction of tau pathology was accompanied by an improvement in the motor function assessed by a wire hang test. Collectively, our results suggest that GSPE can interfere with tau-mediated neurodegenerative mechanisms and ameliorate neurodegenerative phenotype in an animal model of tauopathy. Our studies support further evaluation of GSPE for preventing and/or treating of tauopathies in humans. PMID:22054871

  11. In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals

    PubMed Central

    2014-01-01

    Hyperphosphorylation of the tau protein leading to the formation of neurofibrillary tangles (NFTs) is a common feature in a wide range of neurodegenerative diseases known as tauopathies, which include Alzheimer’s disease (AD) and the frontotemporal dementias (FTDs). Although heavily investigated, the mechanisms underlying the pathogenesis and progression of tauopathies have yet to be fully understood. In this context, several rodent models have been developed that successfully recapitulate the behavioral and neurochemical features of tau pathology, aiming to achieve a better understanding of the link between tau and neurodegeneration. To date, behavioral and biochemical parameters assessed using these models have been conducted using a combination of memory tasks and invasive methods such as cerebrospinal fluid (CSF) sampling or post-mortem analysis. Recently, several novel positron emission tomography (PET) radiopharmaceuticals targeting tau tangles have been developed, allowing for non-invasive in vivo quantification of tau pathology. Combined with tau transgenic models and microPET, these tracers hold the promise of advancing the development of theoretical models and advancing our understanding of the natural history of AD and non-AD tauopathies. In this review, we briefly describe some of the most important insights for understanding the biological basis of tau pathology, and shed light on the opportunity for improved modeling of tau pathology using a combination of tau-radiopharmaceuticals and animal models. PMID:24628994

  12. Altered microtubule organization in small-calibre axons of mice lacking tau protein

    Microsoft Academic Search

    A. Harada; K. Oguchi; S. Okabe; J. Kuno; S. Terada; T. Ohshima; R. Sato-Yoshitake; Y. Takei; T. Noda; N. Hirokawa

    1994-01-01

    THE tau gene encodes a protein (Tau) that is a major neuronal microtubule-associated protein localized mostly in axons1-4. It has microtubule-binding and tubulin-polymerizing activity in vitro 3,4 and is thought to make short crossbridges between axonal microtubules5,6. Further, tau-transfected non-neuronal cells extend long axon-like processes in which microtubule bundles resembling those in axons are formed6-8. In contrast, tau antisense oligo-nucleotides

  13. Interactions between Tau and ?-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease

    PubMed Central

    Roy, Bidisha; Jackson, George R.

    2014-01-01

    Clinical and pathological studies have suggested considerable overlap between tauopathies and synucleinopathies. Several genome-wide association studies have identified alpha-Synuclein (SNCA) and Tau (MAPT) polymorphisms as common risk factors for sporadic Parkinson's disease (PD). However, the mechanisms by which subtle variations in the expression of wild-type SNCA and MAPT influence risk for PD and the underlying cellular events that effect neurotoxicity remain unclear. To examine causes of neurotoxicity associated with the ?-Syn/Tau interaction, we used the fruit fly as a model. We utilized misexpression paradigms in three different tissues to probe the ?-Syn/Tau interaction: the retina, dopaminergic neurons and the larval neuromuscular junction. Misexpression of Tau and ?-Syn enhanced a rough eye phenotype and loss of dopaminergic neurons in fly tauopathy and synucleinopathy models, respectively. Our findings suggest that interactions between ?-Syn and Tau at the cellular level cause disruption of cytoskeletal organization, axonal transport defects and aberrant synaptic organization that contribute to neuronal dysfunction and death associated with sporadic PD. ?-Syn did not alter levels of Tau phosphorylated at the AT8 epitope. However, ?-Syn and Tau colocalized in ubiquitin-positive aggregates in eye imaginal discs. The presence of Tau also led to an increase in urea soluble ?-Syn. Our findings have important implications in understanding the cellular and molecular mechanisms underlying ?-Syn/Tau-mediated synaptic dysfunction, which likely arise in the early asymptomatic phase of sporadic PD. PMID:24430504

  14. Parkinson's disease-associated PINK1 G309D mutation increases abnormal phosphorylation of Tau.

    PubMed

    Ye, Ming; Zhou, Dai; Zhou, Youxin; Sun, Chunming

    2015-04-01

    Mutations in PINK1 gene have been considered the second most common cause of Autosomal Recessive Parkinsonism (ARP). So far, different homozygous PINK1 mutations have been identified in different ARP patients. Abnormal hyperphosphorylation of tau leads to the loss of its biological activity. Multiple lines of evidence have demonstrated that hyperphosphorylated tau is associated with Alzheimer's disease and Parkinson's disease (PD). However, the effects of PD associated PINK1 mutations in tau phosphorylation are unknown. In this study, we investigated the effect of G309D PINK1 mutation in tau phosphorylation. Cells transfected with mutant G309D PINK1 exhibited a significant increase in the phosphorylation of tau protein at the PHF-1 (ser396/404) site. The levels of CDK5, an important activator of tau phosphorylation, did not change in mutant G309D PINK1 transfected cells, suggesting that CDK5 is not involved in tau phosphorylation induced by mutant G309D PINK1. Notably, we found that mutant G309D PINK1 significantly reduced phosphorylation of GSK3? at serine 9, suggesting that alterations in GSK3? activity play an essential role in mutant G309D PINK1-induced tau phosphorylation at the PHF-1 site. PP2A activity maintained consistent in mutant G309D PINK1 transfected cells, suggesting that the increased tau hyperphosphorylation is not ascribed to reduction in PP2A activity. © 2015 IUBMB Life, 67(4):286-290, 2015. PMID:25899925

  15. Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.

    PubMed

    Bretteville, Alexis; Marcouiller, François; Julien, Carl; El Khoury, Noura B; Petry, Franck R; Poitras, Isabelle; Mouginot, Didier; Lévesque, Georges; Hébert, Sébastien S; Planel, Emmanuel

    2012-01-01

    Tau hyperphosphorylation is one hallmark of Alzheimer's disease (AD) pathology. Pharmaceutical companies have thus developed kinase inhibitors aiming to reduce tau hyperphosphorylation. One obstacle in screening for tau kinase inhibitors is the low phosphorylation levels of AD-related phospho-epitopes in normal adult mice and cultured cells. We have shown that hypothermia induces tau hyperphosphorylation in vitro and in vivo. Here, we hypothesized that hypothermia could be used to assess tau kinase inhibitors efficacy. Hypothermia applied to models of biological gradual complexity such as neuronal-like cells, ex vivo brain slices and adult non-transgenic mice leads to tau hyperphosphorylation at multiple AD-related phospho-epitopes. We show that Glycogen Synthase Kinase-3 inhibitors LiCl and AR-A014418, as well as roscovitine, a cyclin-dependent kinase 5 inhibitor, decrease hypothermia-induced tau hyperphosphorylation, leading to different tau phosphorylation profiles. Therefore, we propose hypothermia-induced hyperphosphorylation as a reliable, fast, convenient and inexpensive tool to screen for tau kinase inhibitors. PMID:22761989

  16. Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease.

    PubMed

    Jarero-Basulto, Jose J; Luna-Muñoz, Jose; Mena, Raul; Kristofikova, Zdena; Ripova, Daniela; Perry, George; Binder, Lester I; Garcia-Sierra, Francisco

    2013-12-01

    Truncated tau protein at Asp(421) is associated with neurofibrillary pathology in Alzheimer disease (AD); however, little is known about its presence in the form of nonfibrillary aggregates. Here, we report immunohistochemical staining of the Tau-C3 antibody, which recognizes Asp(421)-truncated tau, in a group of AD cases with different extents of cognitive impairment. In the hippocampus, we found distinct nonfibrillary aggregates of Asp(421)-truncated tau. Unlike Asp(421)-composed neurofibrillary tangles, however, these nonfibrillary pathologies did not increase significantly with respect to the Braak staging and, therefore, make no significant contribution to cognitive impairment. On the other hand, despite in vitro evidence that caspase-3 cleaves monomeric tau at Asp(421), to date, this truncation has not been demonstrated to be executed by this protease in polymeric tau entities. We determined that Asp(421) truncation can be produced by caspase-3 in oligomeric and multimeric complexes of recombinant full-length tau in isolated native tau filaments in vitro and in situ in neurofibrillary tangles analyzed in fresh brain slices from AD cases. Our data suggest that generation of this pathologic Asp(421) truncation of tau in long-lasting fibrillary structures may produce further permanent toxicity for neurons in the brains of patients with AD. PMID:24226268

  17. Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.

    PubMed

    Whittington, Robert A; Virág, László; Gratuze, Maud; Petry, Franck R; Noël, Anastasia; Poitras, Isabelle; Truchetti, Geoffrey; Marcouiller, François; Papon, Marie-Amélie; El Khoury, Noura; Wong, Kevin; Bretteville, Alexis; Morin, Françoise; Planel, Emmanuel

    2015-08-01

    There is developing interest in the potential association between anesthesia and the onset and progression of Alzheimer's disease. Several anesthetics have, thus, been demonstrated to induce tau hyperphosphorylation, an effect mostly mediated by anesthesia-induced hypothermia. Here, we tested the hypothesis that acute normothermic administration of dexmedetomidine (Dex), an intravenous sedative used in intensive care units, would result in tau hyperphosphorylation in vivo and in vitro. When administered to nontransgenic mice, Dex-induced tau hyperphosphorylation persisting up to 6 hours in the hippocampus for the AT8 epitope. Pretreatment with atipamezole, a highly specific ?2-adrenergic receptor antagonist, blocked Dex-induced tau hyperphosphorylation. Furthermore, Dex dose-dependently increased tau phosphorylation at AT8 in SH-SY5Y cells, impaired mice spatial memory in the Barnes maze and promoted tau hyperphosphorylation and aggregation in transgenic hTau mice. These findings suggest that Dex: (1) increases tau phosphorylation, in vivo and in vitro, in the absence of anesthetic-induced hypothermia and through ?2-adrenergic receptor activation, (2) promotes tau aggregation in a mouse model of tauopathy, and (3) impacts spatial reference memory. PMID:26058840

  18. Changes in tau phosphorylation levels in the hippocampus and frontal cortex following chronic stress

    PubMed Central

    Yang, C.; Guo, X.; Wang, G.H.; Wang, H.L.; Liu, Z.C.; Liu, H.; Zhu, Z.X.; Li, Y.

    2014-01-01

    Studies have indicated that early-life or early-onset depression is associated with a 2- to 4-fold increased risk of developing Alzheimers disease (AD). In AD, aggregation of an abnormally phosphorylated form of the tau protein may be a key pathological event. Tau is known to play a major role in promoting microtubule assembly and stabilization, and in maintaining the normal morphology of neurons. Several studies have reported that stress may induce tau phosphorylation. The main aim of the present study was to investigate possible alterations in the tau protein in the hippocampus and frontal cortex of 32 male Sprague-Dawley rats exposed to chronic unpredictable mild stress (CUMS) and then re-exposed to CUMS to mimic depression and the recurrence of depression, respectively, in humans. We evaluated the effects of CUMS, fluoxetine, and CUMS re-exposure on tau and phospho-tau. Our results showed that a single exposure to CUMS caused a significant reduction in sucrose preference, indicating a state of anhedonia. The change in behavior was accompanied by specific alterations in phospho-tau protein levels, but fluoxetine treatment reversed the CUMS-induced impairments. Moreover, changes in sucrose preference and phospho-tau were more pronounced in rats re-exposed to CUMS than in those subjected to a single exposure. Our results suggest that changes in tau phosphorylation may contribute to the link between depression and AD. PMID:24652321

  19. Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

    PubMed Central

    Flach, Katharina; Ramminger, Ellen; Hilbrich, Isabel; Arsalan-Werner, Annika; Albrecht, Franziska; Herrmann, Lydia; Goedert, Michel; Arendt, Thomas; Holzer, Max

    2014-01-01

    Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and in tauopathies can result in tau mislocalization and dysfunction, causing tau aggregation and cell death. To uncover proteins involved in the development of tauopathies, a yeast two-hybrid system was used to screen for tau-interacting proteins. We show that axotrophin/MARCH7, a RING-variant domain containing protein with similarity to E3 ubiquitin ligases interacts with tau. We defined the tau binding domain to amino acids 552–682 of axotrophin comprising the RING-variant domain. Co-immunoprecipitation and co-localization confirmed the specificity of the interaction. Intracellular localization of axotrophin is determined by an N-terminal nuclear targeting signal and a C-terminal nuclear export signal. In AD brain nuclear localization is lost and axotrophin is rather associated with neurofibrillary tangles. We find here that tau becomes mono-ubiquitinated by recombinant tau-interacting RING-variant domain, which diminishes its microtubule-binding. In vitro ubiquitination of four-repeat tau results in incorporation of up to four ubiquitin molecules compared to two molecules in three-repeat tau. In summary, we present a novel tau modification occurring preferentially on 4-repeat tau protein which modifies microtubule-binding and may impact on the pathogenesis of tauopathies. PMID:24905733

  20. Measurement of the top quark pair production cross section in pp collisions at sqrt(s) = 7 TeV in dilepton final states containing a tau

    E-print Network

    CMS Collaboration

    2014-11-07

    The top quark pair production cross section is measured in dilepton events with one electron or muon, and one hadronically decaying tau lepton from the decay t anti-t to (l nu(l)) (tau nu(tau)) b anti-b, where l can be either an electron or a muon. The data sample corresponds to an integrated luminosity of 2.0 inverse femtobarns for the electron channel and 2.2 inverse femtobarns for the muon channel, collected by the CMS detector at the LHC. This is the first measurement of the t anti-t cross section explicitly including tau leptons in proton-proton collisions at sqrt(s) = 7 TeV. The measured value sigma(t anti-t) = 143 +/- 14 (stat.) +/- 22 (syst.) +/- 3 (lumi.) pb is consistent with the standard model predictions.

  1. Measurement of the top quark pair production cross section in pp collisions at sqrt(s) = 7 TeV in dilepton final states containing a tau

    SciTech Connect

    Chatrchyan, Serguei [Yerevan Physics Inst. (Armenia); et al.

    2012-06-01

    The top quark pair production cross section is measured in dilepton events with one electron or muon, and one hadronically decaying tau lepton from the decay t anti-t to (l nu(l)) (tau nu(tau)) b anti-b, where l can be either an electron or a muon. The data sample corresponds to an integrated luminosity of 2.0 inverse femtobarns for the electron channel and 2.2 inverse femtobarns for the muon channel, collected by the CMS detector at the LHC. This is the first measurement of the t anti-t cross section explicitly including tau leptons in proton-proton collisions at sqrt(s)=7 TeV. The measured value sigma(t anti-t) = 143 +/- 14 (stat.) +/- 22 (syst.) +/- 3 (lumi.) pb is consistent with the standard model predictions.

  2. Legendre-Tau approximations for functional differential equations

    NASA Technical Reports Server (NTRS)

    Ito, K.; Teglas, R.

    1983-01-01

    The numerical approximation of solutions to linear functional differential equations are considered using the so called Legendre tau method. The functional differential equation is first reformulated as a partial differential equation with a nonlocal boundary condition involving time differentiation. The approximate solution is then represented as a truncated Legendre series with time varying coefficients which satisfy a certain system of ordinary differential equations. The method is very easy to code and yields very accurate approximations. Convergence is established, various numerical examples are presented, and comparison between the latter and cubic spline approximations is made.

  3. A Sub-millimeterwave ``Flare'' from GG Tau?

    E-print Network

    Gerald H. Moriarty-Schieven; Harold M. Butner

    1996-07-30

    We have monitored the millimeter and submillimeter emission from the young stellar object GG Tau, a T Tauri binary system surrounded by a massive circumbinary disk. We find that between 1992 and 1994, the flux has increased significantly at 800, 1100, and 1300 microns, resulting in a steepening of the observed spectral energy distribution at those wavelengths. Such an increase appears consistent with a modest increase in disk luminosity (a factor of two). The increase in the effective disk temperature might arise from a slight change in the disk heating processes. Alternatively, the flux increase may reflect a sudden change in the underlying dust optical properties.

  4. The Prepared Tau Exon-Specific Antibodies Revealed Distinct Profiles of Tau in CSF of the Patients with Creutzfeldt-Jakob Disease

    PubMed Central

    Chen, Cao; Shi, Qi; Zhang, Bao-Yun; Wang, Gui-Rong; Zhou, Wei; Gao, Chen; Tian, Chan; Mei, Guo-Yong; Han, Yan-Ling; Han, Jun; Dong, Xiao-Ping

    2010-01-01

    Background The diagnostic value of CSF tau for Creutzfeldt-Jakob disease (CJD) has been widely evaluated, showing a markedly disease-relative manner. However, the profiles of tau isoforms in CSF of CJD patients remain unknown. Here, we prepared the exon-specific antibodies against the peptides encoded by exon-2, exon-3 and exon-10 of human tau protein and evaluated the reactive profiles of tau in CSF samples from the patients with probable CJD. Methodology/Principal Findings Sequences encoding exon-2, exon-3 and exon-10 of human tau protein were cloned into a prokaryotic expression vector pGEX-2T. Using recombinant fusion proteins GST-E2, GST-E3 and GST-E10, three tau exon-specific antibodies were elicited. Reliable specificities of the prepared antibodies were obtained after a serial of purification processes, not only in recognizing the tau peptides encoded by exon-2, -3 and -10, but also in distinguishing six recombinant tau isoforms by Western blot and ELISA. Three predominant tau-specific bands were observed in CSF samples with the exon-specific and the commercial tau antibodies, respectively, showing different reactive profiles between the groups of probable CJD and non-CJD. A 65 KD band was detected only in the CSF samples from probable CJD patients, especially with the antibodies against exon-2 (Anti-tE2) and exon-10 (Anit-tE10). The appearances of 65 KD band in CSF correlated well with positive 14-3-3 in CSF and typical abnormality in EEG. Such band was not observed in the CSF samples of six tested genetic CJD patients. Conclusions/Significance Three exon-specific polyclonal antibodies were successfully prepared. Based on these antibodies, different CSF tau profiles in Western blots were observed between the groups of probable CJD and non-CJD. A disease-specific tau band emerged in the CSF samples from probable sporadic CJD, which may supply a new biomarker for screening sporadic CJD. PMID:20686702

  5. The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice

    PubMed Central

    Brelstaff, Jack; Ossola, Bernardino; Neher, Jonas J.; Klingstedt, Therése; Nilsson, K. Peter R.; Goedert, Michel; Spillantini, Maria Grazia; Tolkovsky, Aviva M.

    2015-01-01

    Identification of fluorescent dyes that label the filamentous protein aggregates characteristic of neurodegenerative disease, such as ?-amyloid and tau in Alzheimer's disease, in a live cell culture system has previously been a major hurdle. Here we show that pentameric formyl thiophene acetic acid (pFTAA) fulfills this function in living neurons cultured from adult P301S tau transgenic mice. Injection of pFTAA into 5-month-old P301S tau mice detected cortical and DRG neurons immunoreactive for AT100, an antibody that identifies solely filamentous tau, or MC1, an antibody that identifies a conformational change in tau that is commensurate with neurofibrillary tangle formation in Alzheimer's disease brains. In fixed cultures of dorsal root ganglion (DRG) neurons, pFTAA binding, which also identified AT100 or MC1+ve neurons, followed a single, saturable binding curve with a half saturation constant of 0.14 ?M, the first reported measurement of a binding affinity of a beta-sheet reactive dye to primary neurons harboring filamentous tau. Treatment with formic acid, which solubilizes filamentous tau, extracted pFTAA, and prevented the re-binding of pFTAA and MC1 without perturbing expression of soluble tau, detected using an anti-human tau (HT7) antibody. In live cultures, pFTAA only identified DRG neurons that, after fixation, were AT100/MC1+ve, confirming that these forms of tau pre-exist in live neurons. The utility of pFTAA to discriminate between living neurons containing filamentous tau from other neurons is demonstrated by showing that more pFTAA+ve neurons die than pFTAA-ve neurons over 25 days. Since pFTAA identifies fibrillar tau and other misfolded proteins in living neurons in culture and in animal models of several neurodegenerative diseases, as well as in human brains, it will have considerable application in sorting out disease mechanisms and in identifying disease-modifying drugs that will ultimately help establish the mechanisms of neurodegeneration in human neurodegenerative diseases. PMID:26074756

  6. arXiv:1201.6489v1[hep-ph]31Jan2012 Multi-tau lepton signatures in leptophilic two Higgs

    E-print Network

    arXiv:1201.6489v1[hep-ph]31Jan2012 Multi-tau lepton signatures in leptophilic two Higgs doublet for Theoretical Sciences Taipei 10617, Taiwan We study the feasibility of the Type-X two Higgs doublet model (THDM-X) at collider experiments. In the THDM-X, new Higgs bosons mostly decay into tau leptons in the wide range

  7. Multinomial tau-leaping method for stochastic kinetic simulations

    NASA Astrophysics Data System (ADS)

    Pettigrew, Michel F.; Resat, Haluk

    2007-02-01

    We introduce the multinomial tau-leaping (M?L) method for general reaction networks with multichannel reactant dependencies. The M?L method is an extension of the binomial tau-leaping method where efficiency is improved in several ways. First, ?-leaping steps are determined simply and efficiently using a priori information and Poisson distribution-based estimates of expectation values for reaction numbers over a tentative ?-leaping step. Second, networks are partitioned into closed groups of reactions and corresponding reactants in which no group reactant set is found in any other group. Third, product formation is factored into upper-bound estimation of the number of times a particular reaction occurs. Together, these features allow larger time steps where the numbers of reactions occurring simultaneously in a multichannel manner are estimated accurately using a multinomial distribution. Furthermore, we develop a simple procedure that places a specific upper bound on the total reaction number to ensure non-negativity of species populations over a single multiple-reaction step. Using two disparate test case problems involving cellular processes—epidermal growth factor receptor signaling and a lactose operon model—we show that the ?-leaping based methods such as the M?L algorithm can significantly reduce the number of simulation steps thus increasing the numerical efficiency over the exact stochastic simulation algorithm by orders of magnitude.

  8. Deuterated molecules in DM Tau: DCO+, but no HDO

    E-print Network

    Guilloteau, S; Dutrey, A; Guélin, M; Guilloteau, St\\'{e}phane; Pi\\'{e}tu, Vincent; Dutrey, Anne; Gu\\'{e}lin, Michel

    2006-01-01

    We report the detection of the J=2-1 line of DCO+ in the proto-planetary disk of DM Tau and re-analyze the spectrum covering the 465 GHz transition of HDO in this source, recently published by Ceccarelli et al. (2005). A modelling of the DCO+ line profile with the source parameters derived from high resolution HCO+ observations yields a DCO+/HCO+ abundance ratio of about 0.004, an order of magnitude smaller than that derived in the low mass cores. The re-analysis of the 465 GHz spectrum, using the proper continuum flux (0.5 Jy) and source systemic velocity (6.05 km/s), makes it clear that the absorption features attributed to HDO and C6H are almost certainly unrelated to these species. We show that the line-to-continuum ratio of an absorption line in front of a Keplerian disk can hardly exceed the ratio of the turbulent velocity to the projected rotation velocity at the disk edge, unless the line is optically very thick (tau > 10 000). This ratio is typically 0.1-0.3 in proto-planetary disks and is about 0.15...

  9. Time dependent solution for acceleration of tau-leaping

    SciTech Connect

    Fu, Jin, E-mail: iamfujin@hotmail.com [Department of Computer Science, University of California, Santa Barbara (United States)] [Department of Computer Science, University of California, Santa Barbara (United States); Wu, Sheng, E-mail: sheng@cs.ucsb.edu [Department of Computer Science, University of California, Santa Barbara (United States)] [Department of Computer Science, University of California, Santa Barbara (United States); Petzold, Linda R., E-mail: petzold@cs.ucsb.edu [Department of Computer Science, University of California, Santa Barbara (United States)

    2013-02-15

    The tau-leaping method is often effective for speeding up discrete stochastic simulation of chemically reacting systems. However, when fast reactions are involved, the speed-up for this method can be quite limited. One way to address this is to apply a stochastic quasi-steady state assumption. However we must be careful when using this assumption. If the fast subsystem cannot reach a steady distribution fast enough, the quasi-steady-state assumption will propagate error into the simulation. To avoid these errors, we propose to use the time dependent solution rather than the quasi-steady-state. Generally speaking, the time dependent solution is not easy to derive for an arbitrary network. However, for some common motifs we do have time dependent solutions. We derive the time dependent solutions for these motifs, and then show how they can be used with tau-leaping to achieve substantial speed-ups, including for a realistic model of blood coagulation. Although the method is complicated, we have automated it.

  10. Weighted Hurwitz numbers and hypergeometric $\\tau$-functions: an overview

    E-print Network

    Harnad, J

    2015-01-01

    This is an overview of recent results on the use of 2D Toda $\\tau$-functions as generating functions for multiparametric families of weighted Hurwitz numbers. The Bose-Fermi equivalence composed with the characteristic map provides an isomorphism between the zero charge sector of the Fermionic Fock space and the direct sum of the centers of the group algebra of the symmetric groups $S_n$. Specializing the fermionic formula to the case of diagonal group elements gives $\\tau$-functions of hypergeometric type, for which the expansion over products of Schur functions is diagonal, with coefficients of {\\em content product} type. The corresponding abelian group action on the centre of the $S_n$ group algebra is determined by forming symmetric functions multiplicatively from a weight generating function $G(z)$ and evaluating on the Jucys-Murphy elements of the group algebra. The resulting central elements act diagonally on the basis of orthogonal idempotents and the eigenvalues $r^{G(z)}_\\lambda$ are the {\\em conten...

  11. SPECTROPOLARIMETRY OF THE CLASSICAL T TAURI STAR BP TAU

    SciTech Connect

    Chen, Wei; Johns-Krull, Christopher M., E-mail: wc2@rice.edu, E-mail: cmj@rice.edu [Department of Physics and Astronomy, Rice University, Houston, TX 77005 (United States)

    2013-10-20

    We implement a least-squares deconvolution (LSD) code to study magnetic fields on cool stars. We first apply our code to high-resolution optical echelle spectra of 53 Cam (a magnetic Ap star) and three well-studied cool stars (Arcturus, 61 Cyg A, and ? Boo A) as well as the Sun (by observing the asteroid Vesta) as tests of the code and the instrumentation. Our analysis is based on several hundred photospheric lines spanning the wavelength range 5000 Å to 9000 Å. We then apply our LSD code to six nights of data on the Classical T Tauri Star BP Tau. A maximum longitudinal field of 370 ± 80 G is detected from the photospheric lines on BP Tau. A 1.8 kG dipole tilted at 129° with respect to the rotation axis and a 1.4 kG octupole tilted at 104° with respect to the rotation axis, both with a filling factor of 0.25, best fit our LSD Stokes V profiles. Measurements of several emission lines (He I 5876 Å, Ca II 8498 Å, and 8542 Å) show the presence of strong magnetic fields in the line formation regions of these lines, which are believed to be the base of the accretion footpoints. The field strength measured from these lines shows night-to-night variability consistent with rotation of the star.

  12. Spectropolarimetry of the Classical T Tauri Star BP Tau

    NASA Astrophysics Data System (ADS)

    Chen, Wei; Johns-Krull, Christopher M.

    2013-10-01

    We implement a least-squares deconvolution (LSD) code to study magnetic fields on cool stars. We first apply our code to high-resolution optical echelle spectra of 53 Cam (a magnetic Ap star) and three well-studied cool stars (Arcturus, 61 Cyg A, and ? Boo A) as well as the Sun (by observing the asteroid Vesta) as tests of the code and the instrumentation. Our analysis is based on several hundred photospheric lines spanning the wavelength range 5000 Å to 9000 Å. We then apply our LSD code to six nights of data on the Classical T Tauri Star BP Tau. A maximum longitudinal field of 370 ± 80 G is detected from the photospheric lines on BP Tau. A 1.8 kG dipole tilted at 129° with respect to the rotation axis and a 1.4 kG octupole tilted at 104° with respect to the rotation axis, both with a filling factor of 0.25, best fit our LSD Stokes V profiles. Measurements of several emission lines (He I 5876 Å, Ca II 8498 Å, and 8542 Å) show the presence of strong magnetic fields in the line formation regions of these lines, which are believed to be the base of the accretion footpoints. The field strength measured from these lines shows night-to-night variability consistent with rotation of the star.

  13. Reconnaissance of the Hydrogeology of Ta'u, American Samoa

    USGS Publications Warehouse

    Izuka, Scot K.

    2005-01-01

    Analysis of existing data and information collected on a reconnaissance field visit supports a conceptual model of ground-water occurrence in Ta'u, American Samoa, in which a thin freshwater lens exists in a predominantly high-permeability aquifer that receives high rates of recharge. Because the freshwater lens is thin throughout most of the island, the productivity of wells, especially those near the coast where the lens is the thinnest, is likely to be limited by saltwater intrusion. The landfill in northwestern Ta'u is closer to the north coast of the island than to any of the existing or proposed well sites. Although this may indicate that ground water beneath the landfill would flow away from the existing and proposed well sites, this interpretation may change depending on the hydraulic properties of a fault and rift zone in the area. Of four plausible scenarios tested with a numerical ground-water flow model, only one scenario indicated that ground water from beneath the landfill would flow toward the existing and proposed well sites; the analysis does not, however, assess which of the four scenarios is most plausible. The analysis also does not consider the change in flow paths that will result from ground-water withdrawals, dispersion of contaminants during transport by ground water, other plausible hydrogeologic scenarios, transport of contaminants by surface-water flow, or that sources of contamination other than the landfill may exist. Accuracy of the hydrologic interpretations in this study is limited by the relatively sparse data available for Ta'u. Understanding water resources on Ta'u can be advanced by monitoring rainfall, stream-flow, evaporation, ground-water withdrawals, and water quality, and with accurate surveys of measuring point elevations for all wells and careful testing of well-performance. Assessing the potential for contaminants in the landfill to reach existing and proposed well sites can be improved with additional information on the landfill itself (history, construction, contents, water chemistry), surface-water flow directions, spatial distribution of ground-water levels, and the quality of water in nearby wells. Monitoring water levels and chemistry in one or more monitoring wells between the landfill and existing or proposed wells can provide a means to detect movement of contaminants before they reach production wells. Steps that can be implemented in the short term include analyzing water in the landfill and monitoring of water chemistry and water levels in all existing and new production wells. Placing future wells farther inland may mitigate saltwater intrusion problems, but the steep topography of Ta'u limits the feasibility of this approach. Alternative solutions include distributing ground-water withdrawal among several shallow-penetrating, low-yield wells.

  14. Silencing I2PP2A Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3? Signaling in Human Tau Transgenic Mice

    PubMed Central

    Zhang, Yao; Ma, Rong-Hong; Li, Xia-Chun; Zhang, Jia-Yu; Shi, Hai-Rong; Wei, Wei; Luo, Dan-Ju; Wang, Qun; Wang, Jian-Zhi; Liu, Gong-Ping

    2014-01-01

    Increase of inhibitor-2 of protein phosphatase-2A I2PP2A is associated with protein phosphatase-2A (PP2A) inhibition and tau hyperphosphorylation in Alzheimer’s disease (AD). Down-regulating I2PP2A attenuated amyloidogenesis and improved the cognitive functions in transgenic mice expressing amyloid precursor protein (tg2576). Here, we found that silencing I2PP2A by hippocampal infusion of Lenti - siI2PP2A down-regulated I2PP2A (~45%) with reduction of tau phosphorylation/accumulation, improvement of memory deficits, and dendritic plasticity in 12-month-old human tau transgenic mice. Silencing I2PP2A not only restored PP2A activity but also inhibited glycogen synthase kinase-3? (GSK-3?) with a significant activation of protein kinase A (PKA) and Akt. In HEK293/tau and N2a/tau cells, silencing I2PP2A by pSUPER - siI2PP2A also significantly reduced tau hyperphosphorylation with restoration of PP2A activity and inhibition of GSK-3?, demonstrated by the decreased GSK-3? total protein and mRNA levels, and the increased inhibitory phosphorylation of GSK-3? at serine-9. Furthermore, activation of PKA but not Akt mediated the inhibition of GSK-3? by I2PP2A silencing. We conclude that targeting I2PP2A can improve tau pathologies and memory deficits in human tau transgenic mice, and activation of PKA contributes to GSK-3? inhibition induced by silencing I2PP2A in vitro, suggesting that I2PP2A is a promising multiple target of AD. PMID:24987368

  15. Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology*

    PubMed Central

    Gu, Jiaping; Congdon, Erin E.; Sigurdsson, Einar M.

    2013-01-01

    Aggregated Tau proteins are hallmarks of Alzheimer disease and other tauopathies. Recent studies from our group and others have demonstrated that both active and passive immunizations reduce Tau pathology and prevent cognitive decline in transgenic mice. To determine the efficacy and safety of targeting the prominent 396/404 region, we developed two novel monoclonal antibodies (mAbs) with distinct binding profiles for phospho and non-phospho epitopes. The two mAbs significantly reduced hyperphosphorylated soluble Tau in long term brain slice cultures without apparent toxicity, suggesting the therapeutic importance of targeting the 396/404 region. In mechanistic studies, we found that neurons were the primary cell type that internalized the mAbs, whereas a small amount of mAbs was taken up by microglia cells. Within neurons, the two mAbs were highly colocalized with distinct pathological Tau markers, indicating their affinity toward different stages or forms of pathological Tau. Moreover, the mAbs were largely co-localized with endosomal/lysosomal markers, and partially co-localized with autophagy pathway markers. Additionally, the Fab fragments of the mAbs were able to enter neurons, but unlike the whole antibodies, the fragments were not specifically localized in pathological neurons. In summary, our Tau mAbs were safe and efficient to clear pathological Tau in a brain slice model. Fc-receptor-mediated endocytosis and the endosome/autophagosome/lysosome system are likely to have a critical role in antibody-mediated clearance of Tau pathology. PMID:24089520

  16. A Search for Line Shape and Depth Variations in 51 Pegasi and tau Bootis

    Microsoft Academic Search

    Timothy M. Brown; Rubina Kotak; Scott D. Horner; Edward J. Kennelly; Sylvain Korzennik; P. Nisenson; Robert W. Noyes

    1998-01-01

    Spectroscopic observations of 51 Pegasi and tau Bootis show no periodic changes in the shapes of their line profiles; these results for 51 Peg are in significant conflict with those reported by Gray & Hatzes. Our detection limits are small enough to rule out nonradial pulsations as the cause of the variability in tau Boo, but not in 51 Peg.

  17. Cinnamon extract inhibits tau aggregation associated with Alzheimer’s Disease in vitro

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An aqueous extract of Ceylon cinnamon (C. zeylanicum) was found to inhibit tau aggregation and filament formation, hallmarks of Alzheimer’s disease (AD) in vitro using brain cells taken from patients who died with AD. The extract also promoted complete disassembly of recombinant tau filaments, and ...

  18. The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

    PubMed Central

    van der Harg, J M; Nölle, A; Zwart, R; Boerema, A S; van Haastert, E S; Strijkstra, A M; Hoozemans, J JM; Scheper, W