Non-standard neutrino interactions in the mu–tau sector

DOE PAGES

Mocioiu, Irina; Wright, Warren

2015-04-01

We discuss neutrino mass hierarchy implications arising from the effects of non-standard neutrino interactions on muon rates in high statistics atmospheric neutrino oscillation experiments like IceCube DeepCore. We concentrate on the mu–tau sector, which is presently the least constrained. It is shown that the magnitude of the effects depends strongly on the sign of the ϵμτ parameter describing this non-standard interaction. A simple analytic model is used to understand the parameter space where differences between the two signs are maximized. We discuss how this effect is partially degenerate with changing the neutrino mass hierarchy, as well as how this degeneracymore » could be lifted.« less

MAGIC gamma-ray telescopes hunting for neutrinos and their sources

NASA Astrophysics Data System (ADS)

Góra, D.; Bernardini, E.; Satalecka, K.; Noda, K.; Manganaro, M.; López, M.; MAGIC Collaboration

2017-09-01

The discovery of an astrophysical flux of high-energy neutrinos by the IceCube Collaboration marks a major breakthrough in the ongoing search for the origin of cosmic rays. Presumably, the neutrinos, together with gamma rays, result from pion decay, following hadronic interactions of protons accelerated in astrophysical objects to ultra-relativistic energies. So far, the neutrino sky map shows no significant indication of astrophysical sources. Here, we report first results from follow-up observations, of sky regions where IceCube has detected muon tracks from energetic neutrinos, using the MAGIC telescopes which are sensitive to gamma rays at TeV energies. Furthermore, we show that MAGIC has the potential to distinguish air showers induced by tau neutrinos from the background of hadronic showers in the PeV-EeV energy range, employing a novel analysis method to the data obtained with high-zenith angle observations.

Constraints from primordial nucleosynthesis on the mass of the tau neutrino

NASA Technical Reports Server (NTRS)

Kolb, Edward W.; Turner, Michael S.; Chakravorty, A.; Schramm, David N.

1991-01-01

It is shown that primordial nucleosynthesis excludes a tau-neutrino mass from 0.3 to 25 MeV (Dirac) and 0.5 to 25 MeV (Majorana) provided that its lifetime is not less than about 1 sec, and from 0.3 to 30 MeV (Dirac) and 0.5 to 32 MeV (Majorana) for a lifetime of not less than about 1000 sec. A modest improvement in the laboratory mass limit - from 35 to 25 MeV - would imply that the tau-neutrino mass must be less than 0.5 MeV (provided the lifetime is not less than about 1 sec).

Heavy neutrino decay at SHALON

NASA Astrophysics Data System (ADS)

Sinitsyna, V. G.; Masip, M.; Sinitsyna, V. Y.

2013-06-01

The SHALON Cherenkov telescope has recorded over 2 × 106 extensive air showers during the past 17 years. The analysis of the signal at different zenith angles has included observations from the sub-horizontal direction Θ = 97° This inclination defines an Earth skimming trajectory with 7 km of air and around 1000 km of rock in front of the telescope. During a period of 324 hours of observation, after a cut of shower-like events that may be caused by chaotic sky flashes or reflections on the snow of vertical showers, we have detected 5 air showers of TeV energies. We argue that these events may be caused by the decay of a long-lived penetrating particle entering the atmosphere from the ground and decaying in front of the telescope. We show that this particle can it not be a muon or a tau lepton. As a possible explanation, we discuss two scenarios with an unstable neutrino of mass m ≈ 0.5 GeV and cτ ≈ 30 m. Remarkably, one of these models has been recently proposed to explain an excess of electron-like neutrino events at MiniBooNE.

Is a massive tau neutrino just what cold dark matter needs?

NASA Technical Reports Server (NTRS)

Dodelson, Scott; Gyuk, Geza; Turner, Michael S.

1994-01-01

The cold dark matter (CDM) scenario for structure formation in the Universe is very attractive and has many successes; however, when its spectrum of density perturbations is normalized to the COBE anisotropy measurement the level of inhomogeneity predicted on small scales is too large. This can be remedied by a tau neutrino of mass 1 MeV - 10MeV and lifetime 0.1 sec - 100 sec whose decay products include electron neutrinos because it allows the total energy density in relativistic particles to be doubled without interfering with nucleosynthesis. The anisotropies predicted on the degree scale for 'tau CDM' are larger than standard CDM. Experiments at e(sup +/-) collides may be able to probe such a mass range.

Determination of the Michel parameters and the {tau} neutrino helicity in {tau} decay

DOE Office of Scientific and Technical Information (OSTI.GOV)

CLEO Collaboration

1997-11-01

Using the CLEO II detector at the Cornell Electron Storage Ring operated at {radical} (s) =10.6GeV, we have determined the Michel parameters {rho}, {xi}, and {delta} in {tau}{sup {minus_plus}}{r_arrow}l{sup {minus_plus}}{nu}{bar {nu}} decay as well as the {tau} neutrino helicity parameter h{sub {nu}{sub {tau}}} in {tau}{sup {minus_plus}}{r_arrow}{pi}{sup {minus_plus}}{pi}{sup 0}{nu} decay. From a data sample of 3.02{times}10{sup 6} produced {tau} pairs we analyzed events of the topologies e{sup +}e{sup {minus}}{r_arrow}{tau}{sup +}{tau}{sup {minus}}{r_arrow}(l{sup {plus_minus}}{nu}{bar {nu}})({pi}{sup {minus_plus}}{pi}{sup 0}{nu}) and e{sup +}e{sup {minus}}{r_arrow}{tau}{sup +}{tau}{sup {minus}}{r_arrow}({pi}{sup {plus_minus}}{pi}{sup 0}{bar {nu}})({pi}{sup {minus_plus}}{pi}{sup 0}{nu}). We obtain {rho}=0.747{rho}=0.747{plus_minus}0.010{plus_minus}0.006, {xi}=1.007{plus_minus}0.040{plus_minus}0.015, {xi}{delta}=0.745{plus_minus}0.026{plus_minus}0.009, and h{sub {nu}{sub {tau}}}={minus}0.995{plus_minus}0.010{plus_minus}0.003, where we have used the previouslymore » determined sign of h{sub {nu}{sub {tau}}} [ARGUS Collaboration, H. Albrecht {ital et al.}, Z. Phys. C {bold 58}, 61 (1993); Phys. Lett. B {bold 349}, 576 (1995)]. We also present the Michel parameters as determined from the electron and muon samples separately. All results are in agreement with the standard model V{minus}A interaction. {copyright} {ital 1997} {ital The American Physical Society}« less

Search for Neutrino Decay at SHALON

NASA Astrophysics Data System (ADS)

Sinitsyna, V. G.; Masip, M.; Nikolsky, S. I.; Sinitsyna, V. Y.

2012-08-01

The SHALON Cherenkov telescope has recorded over 2 × 106 extensive air showers during the past 17 years. The analysis of the signal at different zenith angles has included observations from the sub-horizontal direction Θ = 97°. This inclination defines an Earth skimming trajectory with 7 km of air and around 1000 km of rock in front of the telescope. During a period of 324 hours of observation, after a cut of shower-like events that may be caused by chaotic sky flashes or reflections on the snow of vertical showers, we have detected 5 air showers of TeV energies. We argue that these events may be caused by the decay of a long-lived penetrating particle entering the atmosphere from the ground and decaying in front of the telescope. We show that this particle can it not be a muon or a tau lepton. As a possible explanation, we discuss two scenarios with an unstable neutrino of mass m ≈ 0.5 GeV and cτ ≈ 30m. Remarkably, one of these models has been recently proposed to explain an excess of electron-like neutrino events at MiniBooNE.

Search for ultrahigh-energy tau neutrinos with IceCube

NASA Astrophysics Data System (ADS)

Abbasi, R.; Abdou, Y.; Abu-Zayyad, T.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Altmann, D.; Andeen, K.; Auffenberg, J.; Bai, X.; Baker, M.; Barwick, S. W.; Baum, V.; Bay, R.; Beattie, K.; Beatty, J. J.; Bechet, S.; Becker, J. K.; Becker, K.-H.; Bell, M.; Benabderrahmane, M. L.; BenZvi, S.; Berdermann, J.; Berghaus, P.; Berley, D.; Bernardini, E.; Bertrand, D.; Besson, D. Z.; Bindig, D.; Bissok, M.; Blaufuss, E.; Blumenthal, J.; Boersma, D. J.; Bohm, C.; Bose, D.; Böser, S.; Botner, O.; Brayeur, L.; Brown, A. M.; Buitink, S.; Caballero-Mora, K. S.; Carson, M.; Casier, M.; Chirkin, D.; Christy, B.; Clevermann, F.; Cohen, S.; Cowen, D. F.; Cruz Silva, A. H.; D'Agostino, M. V.; Danninger, M.; Daughhetee, J.; Davis, J. C.; De Clercq, C.; Degner, T.; Descamps, F.; Desiati, P.; de Vries-Uiterweerd, G.; DeYoung, T.; Díaz-Vélez, J. C.; Dreyer, J.; Dumm, J. P.; Dunkman, M.; Eisch, J.; Ellsworth, R. W.; Engdegård, O.; Euler, S.; Evenson, P. A.; Fadiran, O.; Fazely, A. R.; Fedynitch, A.; Feintzeig, J.; Feusels, T.; Filimonov, K.; Finley, C.; Fischer-Wasels, T.; Flis, S.; Franckowiak, A.; Franke, R.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Gladstone, L.; Glüsenkamp, T.; Goldschmidt, A.; Goodman, J. A.; Góra, D.; Grant, D.; Groß, A.; Grullon, S.; Gurtner, M.; Ha, C.; Haj Ismail, A.; Hallgren, A.; Halzen, F.; Hanson, K.; Heereman, D.; Heimann, P.; Heinen, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hill, G. C.; Hoffman, K. D.; Hoffmann, B.; Homeier, A.; Hoshina, K.; Huelsnitz, W.; Hulth, P. O.; Hultqvist, K.; Hussain, S.; Ishihara, A.; Jacobi, E.; Jacobsen, J.; Japaridze, G. S.; Johansson, H.; Kappes, A.; Karg, T.; Karle, A.; Kiryluk, J.; Kislat, F.; Klein, S. R.; Köhne, J.-H.; Kohnen, G.; Kolanoski, H.; Köpke, L.; Kopper, S.; Koskinen, D. J.; Kowalski, M.; Krasberg, M.; Kroll, G.; Kunnen, J.; Kurahashi, N.; Kuwabara, T.; Labare, M.; Laihem, K.; Landsman, H.; Larson, M. J.; Lauer, R.; Lünemann, J.; Madsen, J.; Maruyama, R.; Mase, K.; Matis, H. S.; Meagher, K.; Merck, M.; Mészáros, P.; Meures, T.; Miarecki, S.; Middell, E.; Milke, N.; Miller, J.; Montaruli, T.; Morse, R.; Movit, S. M.; Nahnhauer, R.; Nam, J. W.; Naumann, U.; Nowicki, S. C.; Nygren, D. R.; Odrowski, S.; Olivas, A.; Olivo, M.; O'Murchadha, A.; Panknin, S.; Paul, L.; Pérez de los Heros, C.; Pieloth, D.; Posselt, J.; Price, P. B.; Przybylski, G. T.; Rawlins, K.; Redl, P.; Resconi, E.; Rhode, W.; Ribordy, M.; Richman, M.; Riedel, B.; Rodrigues, J. P.; Rothmaier, F.; Rott, C.; Ruhe, T.; Rutledge, D.; Ruzybayev, B.; Ryckbosch, D.; Sander, H.-G.; Santander, M.; Sarkar, S.; Schatto, K.; Scheel, M.; Schmidt, T.; Schöneberg, S.; Schönwald, A.; Schukraft, A.; Schulte, L.; Schultes, A.; Schulz, O.; Schunck, M.; Seckel, D.; Semburg, B.; Seo, S. H.; Sestayo, Y.; Seunarine, S.; Silvestri, A.; Smith, M. W. E.; Spiczak, G. M.; Spiering, C.; Stamatikos, M.; Stanev, T.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Strahler, E. A.; Ström, R.; Stüer, M.; Sullivan, G. W.; Taavola, H.; Taboada, I.; Tamburro, A.; Ter-Antonyan, S.; Tilav, S.; Toale, P. A.; Toscano, S.; van Eijndhoven, N.; Van Overloop, A.; van Santen, J.; Vehring, M.; Voge, M.; Walck, C.; Waldenmaier, T.; Wallraff, M.; Walter, M.; Wasserman, R.; Weaver, Ch.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wiebe, K.; Wiebusch, C. H.; Williams, D. R.; Wischnewski, R.; Wissing, H.; Wolf, M.; Wood, T. R.; Woschnagg, K.; Xu, C.; Xu, D. L.; Xu, X. W.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Zarzhitsky, P.; Zoll, M.

2012-07-01

The first dedicated search for ultrahigh-energy (UHE) tau neutrinos of astrophysical origin was performed using the IceCube detector in its 22-string configuration with an instrumented volume of roughly 0.25km3. The search also had sensitivity to UHE electron and muon neutrinos. After application of all selection criteria to approximately 200 live-days of data, we expect a background of 0.60±0.19(stat)(+0.56)/(-0.58)(syst) events and observe three events, which after inspection, emerge as being compatible with background but are kept in the final sample. Therefore, we set an upper limit on neutrinos of all flavors from UHE astrophysical sources at 90% C.L. of Eν2Φ90(νx)<16.3×10-8GeVcm-2sr-1s-1 over an estimated primary neutrino energy range of 340 TeV to 200 PeV.

Search for neutrino generated air shower candidates with energy ≥ 1019 eV and Zenith angle θ

NASA Astrophysics Data System (ADS)

Knurenko, Stanislav; Petrov, Igor; Sabourov, Artem

2017-06-01

The description of the methodology and results of searching for air showers generated by neutral particles such as high energy gamma quanta and astroneutrinos are presented. For this purpose, we conducted a comprehensive analysis of the data: the electron, the muon and the EAS Cerenkov light, and their response time in scintillation and Cherenkov detectors. Air showers with energy more than 5·1018 eV and zenith angle θ ≥ 55∘ are selected and analyzed. Search results indicate a lack of air shower events formed by gamma-rays or high-energy neutrinos, but it does not mean that such air showers do not exist in nature; for example, experiments that recorded showers having a marked low muon content, i.e., "Muonless", are likely to be candidates for showers produced by neutral primary particles.

BEAMING NEUTRINOS AND ANTI-NEUTRINOS ACROSS THE EARTH TO DISENTANGLE NEUTRINO MIXING PARAMETERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fargion, Daniele; D'Armiento, Daniele; Paggi, Paolo

2012-10-10

A result from MINOS seemed to indicate that the mass splitting and mixing angle of anti-neutrinos is different from that of neutrinos, suggesting a charge-parity-time (CPT) violation in the lepton sector. However, more recent MINOS data reduced the {nu}{sub {mu}}-{nu}-bar{sub {mu}} differences leading to a narrow discrepancy nearly compatible with no CPT violation. However, the last few years of OPERA activity on the appearance of a tau lepton (one unique event) still has not been probed and more tools may be required to disentangle a list of parameters ({mu}-{tau} flavor mixing, tau appearance, any eventual CPT violation, {theta}{sub 13} anglemore » value, and any hierarchy neutrino mass). Atmospheric anisotropy in muon neutrino spectra in the DeepCore, at ten to tens of GeV (unpublished), can hardly reveal asymmetry in the eventual {nu}{sub {mu}}-{nu}-bar{sub {mu}} oscillation parameters. Here we considered how the longest baseline neutrino oscillation available, crossing most of Earth's diameter, may improve the measurement and at best disentangle any hypothetical CPT violation occurring between the earliest (2010) and the present (2012) MINOS bounds (with 6{sigma} a year), while testing {tau} and even the appearance of {tau}-bar at the highest rate. The {nu}{sub {mu}} and {nu}-bar{sub {mu}} disappearance correlated with the tau appearance is considered for those events at the largest distances. We thus propose a beam of {nu}{sub {mu}} and {nu}-bar{sub {mu}} crossing through the Earth, within an OPERA-like experiment from CERN (or Fermilab), in the direction of the IceCube-DeepCore {nu} detector at the South Pole. The ideal energy lies at 21 GeV to test the disappearance or (for any tiny CPT violation) the partial {nu}-bar{sub {mu}} appearance. Such a tuned detection experiment may lead to a strong signature of {tau} or {tau}-bar generation even within its neutral current noise background events: nearly one {tau}-bar or two {tau} a day. The tau appearance

Cosmic muon induced EM showers in NO$$\

DOE PAGES

Yadav, Nitin; Duyang, Hongyue; Shanahan, Peter; ...

2016-11-15

Here, the NuMI Off-Axis v e Appearance (NOvA) experiment is a ne appearance neutrino oscillation experiment at Fermilab. It identifies the ne signal from the electromagnetic (EM) showers induced by the electrons in the final state of neutrino interactions. Cosmic muon induced EM showers, dominated by bremsstrahlung, are abundant in NOvA far detector. We use the Cosmic Muon- Removal technique to get pure EM shower sample from bremsstrahlung muons in data. We also use Cosmic muon decay in flight EM showers which are highly pure EM showers.The large Cosmic-EM sample can be used, as data driven method, to characterize themore » EM shower signature and provides valuable checks of the simulation, reconstruction, particle identification algorithm, and calibration across the NOvA detector.« less

Cosmic muon induced EM showers in NO$$\

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yadav, Nitin; Duyang, Hongyue; Shanahan, Peter

Here, the NuMI Off-Axis v e Appearance (NOvA) experiment is a ne appearance neutrino oscillation experiment at Fermilab. It identifies the ne signal from the electromagnetic (EM) showers induced by the electrons in the final state of neutrino interactions. Cosmic muon induced EM showers, dominated by bremsstrahlung, are abundant in NOvA far detector. We use the Cosmic Muon- Removal technique to get pure EM shower sample from bremsstrahlung muons in data. We also use Cosmic muon decay in flight EM showers which are highly pure EM showers.The large Cosmic-EM sample can be used, as data driven method, to characterize themore » EM shower signature and provides valuable checks of the simulation, reconstruction, particle identification algorithm, and calibration across the NOvA detector.« less

Artificial Neural Network as the FPGA Trigger in the Cyclone V based Front-End for a Detection of Neutrino-Origin Showers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szadkowski, Zbigniew; Glas, Dariusz; Pytel, Krzysztof

Neutrinos play a fundamental role in the understanding of the origin of ultra-high-energy cosmic rays. They interact through charged and neutral currents in the atmosphere generating extensive air showers. However, their a very low rate of events potentially generated by neutrinos is a significant challenge for a detection technique and requires both sophisticated algorithms and high-resolution hardware. A trigger based on a artificial neural network was implemented into the Cyclone{sup R} V E FPGA 5CEFA9F31I7 - the heart of the prototype Front-End boards developed for tests of new algorithms in the Pierre Auger surface detectors. Showers for muon and taumore » neutrino initiating particles on various altitudes, angles and energies were simulated in CORSICA and Offline platforms giving pattern of ADC traces in Auger water Cherenkov detectors. The 3-layer 12-8-1 neural network was taught in MATLAB by simulated ADC traces according the Levenberg-Marquardt algorithm. Results show that a probability of a ADC traces generation is very low due to a small neutrino cross-section. Nevertheless, ADC traces, if occur, for 1-10 EeV showers are relatively short and can be analyzed by 16-point input algorithm. We optimized the coefficients from MATLAB to get a maximal range of potentially registered events and for fixed-point FPGA processing to minimize calculation errors. New sophisticated triggers implemented in Cyclone{sup R} V E FPGAs with large amount of DSP blocks, embedded memory running with 120 - 160 MHz sampling may support a discovery of neutrino events in the Pierre Auger Observatory. (authors)« less

Measurement of the {ital {tau}} Neutrino Helicity and Michel Parameters in Polarized {ital e}{sup +}{ital e}{sup -} Collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steiner, R.; Benvenuti, A.C.; Coller, J.A.

1997-06-01

We present a new measurement of the {tau} neutrino helicity h{sub {nu}{sub {tau}}} and the {tau} Michel parameters {rho} , {eta} , {xi} , and the product {delta}{xi} . The analysis exploits the highly polarized SLC electron beam to extract these quantities directly from a measurement of the {tau} decay spectra, using the 1993{endash}1995 SLD data sample of 4328 e{sup +}e{sup -}{r_arrow}Z{sup 0}{r_arrow}{tau}{sup +}{tau}{sup -} events. From the decays {tau}{r_arrow}{pi}{nu}{sub {tau}} and {tau}{r_arrow}{rho}{nu}{sub {tau}} we obtain a combined value h{sub {nu}{sub {tau}}}=-0.93{plus_minus}0.10{plus_minus} 0.04 . The leptonic decay channels yield combined values of {rho}=0.72{plus_minus}0.09{plus_minus}0.03 , {xi}=1.05{plus_minus}0.35{plus_minus}0.04 , and {delta}{xi}=0.88{plus_minus}0.27{plus_minus}0.04 . {copyright}more » {ital 1997} {ital The American Physical Society}« less

Study of muons near shower cores at sea level using the E594 neutrino detector

NASA Technical Reports Server (NTRS)

Goodman, J. A.; Gupta, S. C.; Freudenreich, H.; Sivaprasad, K.; Tonwar, S. C.; Yodh, G. B.; Ellsworth, R. W.; Goodman, M. C.; Bogert, D.; Burnstein, R.

1985-01-01

The E594 neutrino detector has been used to study the lateral distribution of muons of energy 3 GeV near shower cores. The detector consists of a 340 ton fine grain calorimeter with 400,000 cells of flash chamber and dimensions of 3.7 m x 20 m x 3.7 m (height). The average density in the calorimeter is 1.4 gm/sq cm, and the average Z is 21. The detector was triggered by four 0.6 sq m scintillators placed immediately on the top of the calorimeter. The trigger required at least two of these four counters. The accompanying extensive air showers (EAS) was sampled by 14 scintillation counters located up to 15 m from the calorimeter. Several off line cuts have been applied to the data. Demanding five particles in at least two of the trigger detectors, a total of 20 particles in all of them together, and an arrival angle for the shower 450 deg reduced the data sample to 11053 events. Of these in 4869 cases, a computer algorithm found at least three muons in the calorimeter.

Ultrahigh-energy neutrino follow-up of gravitational wave events GW150914 and GW151226 with the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Aab, A.; Abreu, P.; Aglietta, M.; Al Samarai, I.; Albuquerque, I. F. M.; Allekotte, I.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Ambrosio, M.; Anastasi, G. A.; Anchordoqui, L.; Andrada, B.; Andringa, S.; Aramo, C.; Arqueros, F.; Arsene, N.; Asorey, H.; Assis, P.; Aublin, J.; Avila, G.; Badescu, A. M.; Balaceanu, A.; Barreira Luz, R. J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertaina, M. E.; Bertou, X.; Biermann, P. L.; Billoir, P.; Biteau, J.; Blaess, S. G.; Blanco, A.; Blazek, J.; Bleve, C.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Borodai, N.; Botti, A. M.; Brack, J.; Brancus, I.; Bretz, T.; Bridgeman, A.; Briechle, F. L.; Buchholz, P.; Bueno, A.; Buitink, S.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, L.; Cancio, A.; Canfora, F.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chavez, A. G.; Chinellato, J. A.; Chudoba, J.; Clay, R. W.; Colalillo, R.; Coleman, A.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Coutu, S.; Covault, C. E.; Cronin, J.; D'Amico, S.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Jong, S. J.; De Mauro, G.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; Debatin, J.; Deligny, O.; Di Giulio, C.; Di Matteo, A.; Díaz Castro, M. L.; Diogo, F.; Dobrigkeit, C.; D'Olivo, J. C.; Dorofeev, A.; dos Anjos, R. C.; Dova, M. T.; Dundovic, A.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Falcke, H.; Fang, K.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Fick, B.; Figueira, J. M.; Filipčič, A.; Fratu, O.; Freire, M. M.; Fujii, T.; Fuster, A.; Gaior, R.; García, B.; Garcia-Pinto, D.; Gaté, F.; Gemmeke, H.; Gherghel-Lascu, A.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Głas, D.; Glaser, C.; Glass, H.; Golup, G.; Gómez Berisso, M.; Gómez Vitale, P. F.; González, N.; Gookin, B.; Gorgi, A.; Gorham, P.; Gouffon, P.; Grillo, A. F.; Grubb, T. D.; Guarino, F.; Guedes, G. P.; Hampel, M. R.; Hansen, P.; Harari, D.; Harrison, T. A.; Harton, J. L.; Hasankiadeh, Q.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huege, T.; Hulsman, J.; Insolia, A.; Isar, P. G.; Jandt, I.; Jansen, S.; Johnsen, J. A.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Kasper, P.; Katkov, I.; Keilhauer, B.; Kemp, E.; Kemp, J.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Kuempel, D.; Kukec Mezek, G.; Kunka, N.; Kuotb Awad, A.; LaHurd, D.; Lauscher, M.; Lebrun, P.; Legumina, R.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; Lopes, L.; López, R.; López Casado, A.; Luce, Q.; Lucero, A.; Malacari, M.; Mallamaci, M.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Mariş, I. C.; Marsella, G.; Martello, D.; Martinez, H.; Martínez Bravo, O.; Masías Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Melo, D.; Menshikov, A.; Messina, S.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Mockler, D.; Molina-Bueno, L.; Mollerach, S.; Montanet, F.; Morello, C.; Mostafá, M.; Müller, G.; Muller, M. A.; Müller, S.; Naranjo, I.; Nellen, L.; Neuser, J.; Nguyen, P. H.; Niculescu-Oglinzanu, M.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, H.; Núñez, L. A.; Ochilo, L.; Oikonomou, F.; Olinto, A.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Papenbreer, P.; Parente, G.; Parra, A.; Paul, T.; Pech, M.; Pedreira, F.; Pekala, J.; Pelayo, R.; Peña-Rodriguez, J.; Pereira, L. A. S.; Perrone, L.; Peters, C.; Petrera, S.; Phuntsok, J.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porowski, C.; Prado, R. R.; Privitera, P.; Prouza, M.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Ramos-Pollan, R.; Rautenberg, J.; Ravignani, D.; Reinert, D.; Revenu, B.; Ridky, J.; Risse, M.; Ristori, P.; Rizi, V.; Rodrigues de Carvalho, W.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rogozin, D.; Roth, M.; Roulet, E.; Rovero, A. C.; Saffi, S. J.; Saftoiu, A.; Salazar, H.; Saleh, A.; Salesa Greus, F.; Salina, G.; Sanabria Gomez, J. D.; Sánchez, F.; Sanchez-Lucas, P.; Santos, E. M.; Santos, E.; Sarazin, F.; Sarkar, B.; Sarmento, R.; Sarmiento, C. A.; Sato, R.; Schauer, M.; Scherini, V.; Schieler, H.; Schimp, M.; Schmidt, D.; Scholten, O.; Schovánek, P.; Schröder, F. G.; Schulz, A.; Schulz, J.; Schumacher, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sigl, G.; Silli, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sonntag, S.; Sorokin, J.; Squartini, R.; Stanca, D.; Stanič, S.; Stasielak, J.; Stassi, P.; Strafella, F.; Suarez, F.; Suarez Durán, M.; Sudholz, T.; Suomijärvi, T.; Supanitsky, A. D.; Swain, J.; Szadkowski, Z.; Taboada, A.; Taborda, O. A.; Tapia, A.; Theodoro, V. M.; Timmermans, C.; Todero Peixoto, C. J.; Tomankova, L.; Tomé, B.; Torralba Elipe, G.; Torres Machado, D.; Torri, M.; Travnicek, P.; Trini, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van Bodegom, P.; van den Berg, A. M.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Vergara Quispe, I. D.; Verzi, V.; Vicha, J.; Villaseñor, L.; Vorobiov, S.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weindl, A.; Wiencke, L.; Wilczyński, H.; Winchen, T.; Wittkowski, D.; Wundheiler, B.; Wykes, S.; Yang, L.; Yelos, D.; Yushkov, A.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zepeda, A.; Zimmermann, B.; Ziolkowski, M.; Zong, Z.; Zuccarello, F.; Pierre Auger Collaboration

2016-12-01

On September 14, 2015 the Advanced LIGO detectors observed their first gravitational wave (GW) transient GW150914. This was followed by a second GW event observed on December 26, 2015. Both events were inferred to have arisen from the merger of black holes in binary systems. Such a system may emit neutrinos if there are magnetic fields and disk debris remaining from the formation of the two black holes. With the surface detector array of the Pierre Auger Observatory we can search for neutrinos with energy Eν above 100 PeV from pointlike sources across the sky with equatorial declination from about -6 5 ° to +6 0 ° , and, in particular, from a fraction of the 90% confidence-level inferred positions in the sky of GW150914 and GW151226. A targeted search for highly inclined extensive air showers, produced either by interactions of downward-going neutrinos of all flavors in the atmosphere or by the decays of tau leptons originating from tau-neutrino interactions in the Earth's crust (Earth-skimming neutrinos), yielded no candidates in the Auger data collected within ±500 s around or 1 day after the coordinated universal time (UTC) of GW150914 and GW151226, as well as in the same search periods relative to the UTC time of the GW candidate event LVT151012. From the nonobservation we constrain the amount of energy radiated in ultrahigh-energy neutrinos from such remarkable events.

Measurement of top quark pair production cross section in proton antiproton collisions at center of mass energy 1.96TeV in the tau+ jets final state using 1fb-1 of data

NASA Astrophysics Data System (ADS)

Hossain, Sohrab

This dissertation presents a new measurement of pp¯ → tt¯X production at s = 1.96 TeV using 974.2 pb-1 of data collected with the DO detector between 2002 and 2006. We focus on the final state where the W boson from one of the top quarks decays into a tau lepton and its associated neutrino, while the other W boson decays into a quark-antiquark pair. We aim to select those events in which the tau lepton subsequently decays hadronically, meaning to one or three charged hadrons, zero or more neutral hadrons and a tau neutrino (the charge conjugate processes are implied in all of the above). The observable signature thus consists of a narrow calorimeter shower with associated track(s) characteristic of a hadronic tau decay, four or more jets, of which two are initiated by b quarks accompanying the W's in the top quark decays, and a large net missing momentum in the transverse plane due to the energetic neutrino-antineutrino pair that leave no trace in the detector media. The preliminary result for the measured cross section is: stt= 6.9+1.2-1.2 stat +0.8-0.7 syst +/-0.4lumi pb. This indicates that our finding is consistent with the Standard Model prediction.

RICE bounds on cosmogenic neutrino fluxes and interactions

NASA Astrophysics Data System (ADS)

Hussain, Shahid

2005-04-01

Assuming standard model interactions we calculate shower rates induced by cosmogenic neutrinos in ice, and we bound the cosmogenic neutrino fluxes using RICE 2000-2004 results. Next we assume new interactions due to extra- dimensional, low-scale gravity (i.e. black hole production and decay; graviton mediated deep inelastic scattering) and calculate enhanced shower rates induced by cosmogenic neutrinos in ice. With the help of RICE 2000-2004 results, we survey bounds on low scale gravity parameters for a range of cosmogenic neutrino flux models.

Mass relation for neutrinos

PubMed

Babu; Barr

2000-08-07

A generalization of the well-known Georgi-Jarlskog relation (m(&mgr;)/m(tau)) = 3(m(s)/m(b)) to neutrinos is found in the context of SO(10). This new relation is (m(nu(&mgr;))/m(nu(tau))) = 16(m(c)/m(t)), which is consistent with present data, assuming the Mikheyev-Smirnov-Wolfenstein solution to the solar neutrino problem.

Signals of HE atmospheric μ decay in flight around the Sun’s albedo versus astrophysical νμ and ντ traces in the Moon shadow

NASA Astrophysics Data System (ADS)

Fargion, Daniele; Oliva, Pietro; de Sanctis Lucentini, Pier Giorgio; Khlopov, Maxim Yu.

The Sun albedo of Cosmic Rays (CRs) at GeVs energy has been discovered recently by the FERMI satellite. They are traces of atmospheric CRs hitting solar atmosphere and reflecting skimming gamma photons. Even if relevant for astrophysics, as being a trace of atmospheric solar CR noises they cannot offer any signal of neutrino astronomy. On the contrary, the Moon with no atmosphere, may become soon a novel filtering calorimeter and an amplifier of energetic muon astronomical neutrinos (at TeV up to hundred TeVs energy); these lepton tracks leave an imprint in their beta decay while in flight to Earth. Their TeV electron air-shower are among the main signals. Also, a more energetic, but more rare, PeV up to EeV tau lunar neutrino events may be escaping as a tau lepton from the Moon: τ PeV secondaries, then, may be shining on Earth’s atmosphere in lunar shadows in a surprising way. One or a few gamma air-shower events inside the Moon shadows may occur each year in near future Cherenkov telescope array (CTA) or large high altitude air shower observatory (LHAASO) TeV gamma array detector, assuming a nonnegligible astrophysical TeV up to hundred TeV neutrino component (with respect to our terrestrial ruling atmospheric ones); these signals will open a new wonderful passe-partout keyhole for neutrino, been seen along the Moon. The lunar solid angle is small and the muon or tau expected rate is rare, but with the future largest tau radio array as the giant radio array for neutrino detection (GRAND), one might well discover such neutrino imprint.

Simulation studies of reconstruction of hadron shower direction in INO ICAL detector

NASA Astrophysics Data System (ADS)

Devi, M. M.; Dighe, A.; Indumathi, D.; Lakshmi, S. M.

2018-03-01

The proposed Iron Calorimeter (ICAL) at India-based Neutrino Observatory (INO) will be a 50 kt magnetised iron detector for the detection of atmospheric neutrinos. The atmospheric neutrinos interact via both charged current (CC) and neutral current (NC) interactions with the target iron to produce the detectable final state particles. While CC νμ (bar nuμ) leave a muon track and a hadron shower in the detector, the NC will leave only a hadron shower apart from the secondary invisible neutrino. A GEANT4 based simulation studies to reconstruct hadron showers in CC and NC, using two techniques namely the Orientation Matrix Method (OMM) and the Raw Hit Method (RHM) are presented here. While OMM requires information about the interaction vertex obtained from muon track reconstruction, RHM requires only the shower hit positions and timings and no vertex information and hence can be used for NC events as well. Hadrons from neutrino events generated with NUANCE neutrino generator are analysed. For hadrons in the energy range 0.5-15 GeV produced in CC νμ and bar nuμ interactions, a Δθ'h resolution of around 19o-9o (around 20.5o-12o) is obtained in the |cosθ'h|=[0.8, 1] bin with OMM (RHM). For NC events in the same true energy and direction bins, Δθ'h resolution varies from around 20.5o-13o, from RHM only. OMM (RHM) gives a resolution of about 55o-20o (38o-14o) for the angle between the muon and the hadron shower, βμ h', in the [E'had;cos θ'h] range [0.5-15 GeV; [0.8,1.0

An all-sky, three-flavor search for neutrinos from gamma-ray bursts with the icecube neutrino observatory

NASA Astrophysics Data System (ADS)

Hellauer, Robert Eugene, III

Ultra high energy cosmic rays (UHECRs), defined by energy greater than 10. 18 eV, have been observed for decades, but their sources remain unknown. Protons and heavy ions, which comprise cosmic rays, interact with galactic and intergalactic magnetic fields and, consequently, do not point back to their sources upon measurement. Neutrinos, which are inevitably produced in photohadronic interactions, travel unimpeded through the universe and disclose the directions of their sources. Among the most plausible candidates for the origins of UHECRs is a class of astrophysical phenomena known as gamma-ray bursts (GRBs). GRBs are the most violent and energetic events witnessed in the observable universe. The IceCube Neutrino Observatory, located in the glacial ice 1450 m to 2450 m below the South Pole surface, is the largest neutrino detector in operation. IceCube detects charged particles, such as those emitted in high energy neutrino interactions in the ice, by the Cherenkov light radiated by these particles. The measurement of neutrinos of 100 TeV energy or greater in IceCube correlated with gamma-ray photons from GRBs, measured by spacecraft detectors, would provide evidence of hadronic interaction in these powerful phenomena and confirm their role in ultra high energy cosmic ray production. This work presents the first IceCube GRB-neutrino coincidence search optimized for charged-current interactions of electron and tau neutrinos as well as neutral-current interactions of all neutrino flavors, which produce nearly spherical Cherenkov light showers in the ice. These results for three years of data are combined with the results of previous searches over four years of data optimized for charged-current muon neutrino interactions, which produce extended Cherenkov light tracks. Several low significance events correlated with GRBs were detected, but are consistent with the background expectation from atmospheric muons and neutrinos. The combined results produce limits that

Ultrahigh-energy neutrino follow-up of gravitational wave events GW150914 and GW151226 with the Pierre Auger Observatory

DOE PAGES

Aab, A.; Abreu, P.; Aglietta, M.; ...

2016-12-30

On September 14, 2015 the Advanced LIGO detectors observed their first gravitational wave (GW) transient GW150914. This was followed by a second GW event observed on December 26, 2015. Both events were inferred to have arisen from the merger of black holes in binary systems. Such a system may emit neutrinos if there are magnetic fields and disk debris remaining from the formation of the two black holes. With the surface detector array of the Pierre Auger Observatory we can search for neutrinos with energy Eν above 100 PeV from point like sources across the sky with equatorial declination from aboutmore » -65° to +60°, and, in particular, from a fraction of the 90% confidence-level inferred positions in the sky of GW150914 and GW151226. A targeted search for highly inclined extensive air showers, produced either by interactions of downward-going neutrinos of all flavors in the atmosphere or by the decays of tau leptons originating from tau-neutrino interactions in the Earth’s crust (Earth-skimming neutrinos), yielded no candidates in the Auger data collected within ±500 s around or 1 day after the coordinated universal time (UTC) of GW150914 and GW151226, as well as in the same search periods relative to the UTC time of the GW candidate event LVT151012. As a result, from the non-observation we constrain the amount of energy radiated in ultrahigh-energy neutrinos from such remarkable events.« less

Big World of Small Neutrinos

Science.gov Websites

electron neutrino, muon neutrino, or tau neutrino. The three different neutrinos are complemented by anti of the neutrinos we detect will look different (have a different flavor) compared to the time they Big World of Small Neutrinos Neutrinos will find you! Fig 1: Hubble image of the deep field

Five years of searches for point sources of astrophysical neutrinos with the AMANDA-II neutrino telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Achterberg, A.; Duvoort, M. R.; Heise, J.

2007-05-15

We report the results of a five-year survey of the northern sky to search for point sources of high energy neutrinos. The search was performed on the data collected with the AMANDA-II neutrino telescope in the years 2000 to 2004, with a live time of 1001 days. The sample of selected events consists of 4282 upward going muon tracks with high reconstruction quality and an energy larger than about 100 GeV. We found no indication of point sources of neutrinos and set 90% confidence level flux upper limits for an all-sky search and also for a catalog of 32 selectedmore » sources. For the all-sky search, our average (over declination and right ascension) experimentally observed upper limit {phi}{sup 0}=((E/1 TeV)){sup {gamma}}{center_dot}(d{phi}/dE) to a point source flux of muon and tau neutrino (detected as muons arising from taus) is {phi}{sub {nu}{sub {mu}}+{nu}{sub {mu}}{sup 0}}+{phi}{sub {nu}{sub {tau}}+{nu}{sub {tau}}}{sup 0}=11.1x 10{sup -11} TeV{sup -1} cm{sup -2} s{sup -1}, in the energy range between 1.6 TeV and 2.5 PeV for a flavor ratio {phi}{sub {nu}{sub {mu}}+{nu}{sub {mu}}{sup 0}}/{phi}{sub {nu}{sub {tau}}+{nu}{sub {tau}}}{sup 0}=1 and assuming a spectral index {gamma}=2. It should be noticed that this is the first time we set upper limits to the flux of muon and tau neutrinos. In previous papers we provided muon neutrino upper limits only neglecting the sensitivity to a signal from tau neutrinos, which improves the limits by 10% to 16%. The value of the average upper limit presented in this work corresponds to twice the limit on the muon neutrino flux {phi}{sub {nu}{sub {mu}}+{nu}{sub {mu}}}{sup 0}=5.5x10{sup -11} TeV{sup -1} cm{sup -2} s{sup -1}. A stacking analysis for preselected active galactic nuclei and a search based on the angular separation of the events were also performed. We report the most stringent flux upper limits to date, including the results of a detailed assessment of systematic uncertainties.« less

Cherenkov flashes and fluorescence flares on telescopes: New lights on UHECR spectroscopy while unveiling neutrinos astronomy

NASA Astrophysics Data System (ADS)

Fargion, D.; Oliva, P.; Massa, F.; Moreno, G.

2008-04-01

conversions (in cosmic distances), are also producing penetrating UHE EeV lepton taus that could sample, better and deeper than PeVs ones, the Earth skin. Such almost horizontal and up-going tau showers, originated by UHE astronomical neutrino, may shower and flash by fluorescence and/or Cherenkov diffused lights at AUGER sky in a few years (nearly three). Vice versa, at Hess, MAGIC and VERITAS horizons, at tens or a hundred km distances, the same up-going ττ¯ air-showers might rise via fluorescence. On axis they might blaze (rarely) as a Cherenkov flashes below the horizons, possibly correlated to BL Lac or GRB activity. Also UHE (1 0.1 EeV) GZK τ showering can be observed upward once reflected onto clouds. The geomagnetic splitting may tag the energy as well as the inclined shower footprint as seen in a recent peculiar event in AUGER. Additional stereoscopic detection may define the event origination distance and its consequent primary composition, extending our understanding on UHECR composition.

Probing a four flavor vis-a-vis three flavor neutrino mixing for ultrahigh energy neutrino signals at a 1 km2 detector

NASA Astrophysics Data System (ADS)

Pandey, Madhurima; Majumdar, Debasish; Dutta Banik, Amit

2018-05-01

We consider a four-flavor scenario for the neutrinos where an extra sterile neutrino is introduced to the three families of active neutrinos and study the deviation from the three-flavor scenario in the ultrahigh-energy (UHE) regime. We calculate the possible muon and shower yields at a 1 km2 detector such as IceCube for these neutrinos from distant UHE sources, e.g., gamma-ray bursts, etc. Similar estimations for muon and shower yields are also obtained for the three-flavor case. Comparing the two results, we find considerable differences between the yields for these two cases. This can be useful for probing the existence of a fourth sterile component using UHE neutrino flux.

Experimental Neutrino Physics and Astrophysics with the IMB-3 Detector

NASA Astrophysics Data System (ADS)

Casper, David William

1990-01-01

Description of the universe on the smallest (elementary particle physics) and largest (cosmology) scales has become dependent on the properties of the most weakly interacting fundamental particle known, the neutrino. The IMB experiment, designed to study nucleon decay, is also the world's largest detector of neutrinos. The experiment uses 6800 tons (3300 tons fiducial) of water as both target and detecting medium. Relativistic charges particles traversing the water radiate Cerenkov light. The distinctive ring patterns are imaged by 2048 light collectors (each a photo-multiplier tube coupled with a wavelength-shifting plate) distributed over the surfaces of the tank. This dissertation describes the IMB-3 detector, a four-fold increase in sensitivity over the original apparatus. Neutrino interactions of both atmospheric and extragalactic origin were collected during a 3.4 kiloton-year exposure. A consequence of non-zero neutrino mass could be oscillation of neutrino flavor. The energies and long flight distances of atmospheric neutrinos offer a unique opportunity to explore this possibility. To study the composition of the atmospheric neutrinos, single-ring events are classified as showering or non-showering using the geometry of the Cerenkov pattern. A simulation of neutrino interactions and a model of atmospheric neutrino production are used to predict the composition of the sample. The showering/non-showering character of an event is strongly correlated with the flavor of its neutrino parent. In the lepton momentum range p < 1500 MeV/c, non-showering events comprise 41 +/- 3(stat.) +/- 2(syst.)% of the total. The fraction expected is 51 +/- 5(syst.)%. Although this is evidence for an anomaly in the composition of atmospheric neutrinos, the 2sigma deviation is not sufficient to require neutrino oscillations. Eight interactions recorded over a six second interval on February 23, 1987 are coincident with the discovery of Supernova 1987a. These data, together with

First all-flavor neutrino pointlike source search with the ANTARES neutrino telescope

NASA Astrophysics Data System (ADS)

Albert, A.; André, M.; Anghinolfi, M.; Anton, G.; Ardid, M.; Aubert, J.-J.; Avgitas, T.; Baret, B.; Barrios-Martí, J.; Basa, S.; Belhorma, B.; Bertin, V.; Biagi, S.; Bormuth, R.; Bourret, S.; Bouwhuis, M. C.; Brânzaş, H.; Bruijn, R.; Brunner, J.; Busto, J.; Capone, A.; Caramete, L.; Carr, J.; Celli, S.; Cherkaoui El Moursli, R.; Chiarusi, T.; Circella, M.; Coelho, J. A. B.; Coleiro, A.; Coniglione, R.; Costantini, H.; Coyle, P.; Creusot, A.; Díaz, A. F.; Deschamps, A.; de Bonis, G.; Distefano, C.; di Palma, I.; Domi, A.; Donzaud, C.; Dornic, D.; Drouhin, D.; Eberl, T.; El Bojaddaini, I.; El Khayati, N.; Elsässer, D.; Enzenhöfer, A.; Ettahiri, A.; Fassi, F.; Felis, I.; Fusco, L. A.; Galatà, S.; Gay, P.; Giordano, V.; Glotin, H.; Grégoire, T.; Gracia Ruiz, R.; Graf, K.; Hallmann, S.; van Haren, H.; Heijboer, A. J.; Hello, Y.; Hernández-Rey, J. J.; Hößl, J.; Hofestädt, J.; Hugon, C.; Illuminati, G.; James, C. W.; de Jong, M.; Jongen, M.; Kadler, M.; Kalekin, O.; Katz, U.; Kießling, D.; Kouchner, A.; Kreter, M.; Kreykenbohm, I.; Kulikovskiy, V.; Lachaud, C.; Lahmann, R.; Lefèvre, D.; Leonora, E.; Lotze, M.; Loucatos, S.; Marcelin, M.; Margiotta, A.; Marinelli, A.; Martínez-Mora, J. A.; Mele, R.; Melis, K.; Michael, T.; Migliozzi, P.; Moussa, A.; Navas, S.; Nezri, E.; Organokov, M.; Pǎvǎlaş, G. E.; Pellegrino, C.; Perrina, C.; Piattelli, P.; Popa, V.; Pradier, T.; Quinn, L.; Racca, C.; Riccobene, G.; Sánchez-Losa, A.; Saldaña, M.; Salvadori, I.; Samtleben, D. F. E.; Sanguineti, M.; Sapienza, P.; Schüssler, F.; Sieger, C.; Spurio, M.; Stolarczyk, Th.; Taiuti, M.; Tayalati, Y.; Trovato, A.; Turpin, D.; Tönnis, C.; Vallage, B.; van Elewyck, V.; Versari, F.; Vivolo, D.; Vizzoca, A.; Wilms, J.; Zornoza, J. D.; Zúñiga, J.; ANTARES Collaboration

2017-10-01

A search for cosmic neutrino sources using the data collected with the ANTARES neutrino telescope between early 2007 and the end of 2015 is performed. For the first time, all neutrino interactions—charged- and neutral-current interactions of all flavors—are considered in a search for point-like sources with the ANTARES detector. In previous analyses, only muon neutrino charged-current interactions were used. This is achieved by using a novel reconstruction algorithm for shower-like events in addition to the standard muon track reconstruction. The shower channel contributes about 23% of all signal events for an E-2 energy spectrum. No significant excess over background is found. The most signal-like cluster of events is located at (α ,δ )=(343.8 ° ,23.5 ° ) with a significance of 1.9 σ . The neutrino flux sensitivity of the search is about E2d Φ /d E =6 ×10-9 GeV cm-2 s-1 for declinations from -90 ° up to -42 ° , and below 10-8 GeV cm-2 s-1 for declinations up to 5°. The directions of 106 source candidates and 13 muon track events from the IceCube high-energy sample events are investigated for a possible neutrino signal and upper limits on the signal flux are determined.

Atmospheric electron neutrinos in the MINOS far detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Speakman, Benjamin Phillip

2007-01-01

Neutrinos produced as a result of cosmic-ray interactions in the earth's atmosphere offer a powerful probe into the nature of this three-membered family of low-mass, weakly-interacting particles. Ten years ago, the Super-Kamiokande Experiment has confirmed earlier indications that neutrinos undergo lepton-flavor oscillations during propagation, proving that they are massive contrary to the previous Standard Model assumptions. The Soudan Underground Laboratory, located in northern Minnesota, was host to the Soudan2 Experiment, which has made important contributions to atmospheric neutrino research. This same lab has more recently been host to the MINOS far detector, a neutrino detector which serves as the downstream element of an accelerator-based long-baseline neutrino-oscillation experiment. This thesis has examined 418.5 live days of atmospheric neutrino data (fiducial exposure of 4.18 kton-years) collected in the MINOS far detector prior to the activation of the NuMI neutrino beam, with a specific emphasis on the investigation of electron-type neutrino interactions. Atmospheric neutrino interaction candidates have been selected and separated into showering or track-like events. The showering sample consists of 89 observed events, while the track-like sample consists of 112 observed events. Based on the Bartol atmospheric neutrino flux model of Barr et al. plus a Monte Carlo (MC) simulation of interactions in the MINOS detector, the expected yields of showering and track-like events in the absence of neutrino oscillations are 88.0 ± 1.0 and 149.1 ± 1.0 respectively (where the uncertainties reflect only the limited MC statistics). Major systematic uncertainties, especially those associated with the flux model, are cancelled by forming a double ratio of these observed and expected yields: Rmore » $$data\\atop{trk/shw}$$/R$$MC\\atop{trk/shw}$$ = 0.74$$+0.12\\atop{-1.0}$$(stat.) ± 0.04 (syst.) This double ratio should be equal to unity in the absence of

A New Neutrino Oscillation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parke, Stephen J.; /Fermilab

2011-07-01

Starting in the late 1960s, neutrino detectors began to see signs that neutrinos, now known to come in the flavors electron ({nu}{sub e}), muon ({nu}{sub {mu}}), and tau ({nu}{sub {tau}}), could transform from one flavor to another. The findings implied that neutrinos must have mass, since massless particles travel at the speed of light and their clocks, so to speak, don't tick, thus they cannot change. What has since been discovered is that neutrinos oscillate at two distinct scales, 500 km/GeV and 15,000 km/GeV, which are defined by the baseline (L) of the experiment (the distance the neutrino travels) dividedmore » by the neutrino energy (E). Neutrinos of one flavor can oscillate into neutrinos of another flavor at both L/E scales, but the amplitude of these oscillations is different for the two scales and depends on the initial and final flavor of the neutrinos. The neutrino states that propogate unchanged in time, the mass eigenstates {nu}1, {nu}2, {nu}3, are quantum mechanical mixtures of the electron, muon, and tau neutrino flavors, and the fraction of each flavor in a given mass eigenstate is controlled by three mixing angles and a complex phase. Two of these mixing angles are known with reasonable precision. An upper bound exists for the third angle, called {theta}{sub 13}, which controls the size of the muon neutrino to electron neutrino oscillation at an L/E of 500 km/GeV. The phase is completely unknown. The existence of this phase has important implications for the asymmetry between matter and antimatter we observe in the universe today. Experiments around the world have steadily assembled this picture of neutrino oscillation, but evidence of muon neutrino to electron neutrino oscillation at 500 km/GeV has remained elusive. Now, a paper from the T2K (Tokai to Kamioka) experiment in Japan, reports the first possible observation of muon neutrinos oscillating into electron neutrinos at 500 km/GeV. They see 6 candidate signal events, above an expected

Electric Field Strength Of Coherent Radio Emission In Rock Salt Concerning Ultra High-Energy Neutrino Detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watanabe, Y.; Chiba, M.; Yasuda, O.

2006-07-12

Detection possibility of ultra high-energy (UHE) neutrino (E >1015 eV) in natural huge rock salt formation has been studied. Collision between the UHE neutrino and the rock salt produces electromagnetic (EM) shower. Charge difference (excess electrons) between electrons and positrons in EM shower radiates radio wave coherently (Askar'yan effect). Angular distribution and frequency spectrum of electric field strength of radio wave radiated from 3-dimensional EM shower in rock salt are presented.

Ultrahigh Energy Neutrinos at the Pierre Auger Observatory

DOE PAGES

Abreu, P.; Aglietta, M.; Ahlers, M.; ...

2013-01-01

The observation of ultrahigh energy neutrinos (UHE ν s) has become a priority in experimental astroparticle physics. UHE ν s can be detected with a variety of techniques. In particular, neutrinos can interact in the atmosphere (downward-going ν ) or in the Earth crust (Earth-skimming ν ), producing air showers that can be observed with arrays of detectors at the ground. With the surface detector array of the Pierre Auger Observatory we can detect these types of cascades. The distinguishing signature for neutrino events is the presence of very inclined showers produced close to the ground (i.e., after having traversedmore » a large amount of atmosphere). In this work we review the procedure and criteria established to search for UHE ν s in the data collected with the ground array of the Pierre Auger Observatory. This includes Earth-skimming as well as downward-going neutrinos. No neutrino candidates have been found, which allows us to place competitive limits to the diffuse flux of UHE ν s in the EeV range and above.« less

Trigger and Readout System for the Ashra-1 Detector

NASA Astrophysics Data System (ADS)

Aita, Y.; Aoki, T.; Asaoka, Y.; Morimoto, Y.; Motz, H. M.; Sasaki, M.; Abiko, C.; Kanokohata, C.; Ogawa, S.; Shibuya, H.; Takada, T.; Kimura, T.; Learned, J. G.; Matsuno, S.; Kuze, S.; Binder, P. M.; Goldman, J.; Sugiyama, N.; Watanabe, Y.

Highly sophisticated trigger and readout system has been developed for All-sky Survey High Resolution Air-shower (Ashra) detector. Ashra-1 detector has 42 degree diameter field of view. Detection of Cherenkov and fluorescence light from large background in the large field of view requires finely segmented and high speed trigger and readout system. The system is composed of optical fiber image transmission system, 64 × 64 channel trigger sensor and FPGA based trigger logic processor. The system typically processes the image within 10 to 30 ns and opens the shutter on the fine CMOS sensor. 64 × 64 coarse split image is transferred via 64 × 64 precisely aligned optical fiber bundle to a photon sensor. Current signals from the photon sensor are discriminated by custom made trigger amplifiers. FPGA based processor processes 64 × 64 hit pattern and correspondent partial area of the fine image is acquired. Commissioning earth skimming tau neutrino observational search was carried out with this trigger system. In addition to the geometrical advantage of the Ashra observational site, the excellent tau shower axis measurement based on the fine imaging and the night sky background rejection based on the fine and fast imaging allow zero background tau shower search. Adoption of the optical fiber bundle and trigger LSI realized 4k channel trigger system cheaply. Detectability of tau shower is also confirmed by simultaneously observed Cherenkov air shower. Reduction of the trigger threshold appears to enhance the effective area especially in PeV tau neutrino energy region. New two dimensional trigger LSI was introduced and the trigger threshold was lowered. New calibration system of the trigger system was recently developed and introduced to the Ashra detector

First search for atmospheric and extraterrestrial neutrino-induced cascades with the IceCube detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abbasi, R.; Aguilar, J. A.; Andeen, K.

2011-10-01

We report on the first search for atmospheric and for diffuse astrophysical neutrino-induced showers (cascades) in the IceCube detector using 257 days of data collected in the year 2007-2008 with 22 strings active. A total of 14 events with energies above 16 TeV remained after event selections in the diffuse analysis, with an expected total background contribution of 8.3{+-}3.6. At 90% confidence we set an upper limit of E{sup 2}{Phi}{sub 90%CL}<3.6x10{sup -7} GeV{center_dot}cm{sup -2}{center_dot}s{sup -1}{center_dot}sr{sup -1} on the diffuse flux of neutrinos of all flavors in the energy range between 24 TeV and 6.6 PeV assuming that {Phi}{proportional_to}E{sup -2} andmore » the flavor composition of the {nu}{sub e} ratio {nu}{sub {mu}} ratio {nu}{sub {tau}} flux is 1 ratio 1 ratio 1 at the Earth. The atmospheric neutrino analysis was optimized for lower energies. A total of 12 events were observed with energies above 5 TeV. The observed number of events is consistent with the expected background, within the uncertainties.« less

Atmospheric neutrinos and proton decay in Super-Kamiokande and Hyper-Kamiokande

NASA Astrophysics Data System (ADS)

Li, Zepeng; Super-Kamiokande Collaboration; Hyper-Kamiokande Collaboration

2017-06-01

Super-Kamiokande is a 50 kton water Cherenkov detector, which has been in operation since 1996. Super-Kamiokande atmospheric neutrino data have a preference for the normal neutrino mass hierarchy (Δχ2 = χNH2- χIH2 = - 4.3) when the constraints from reactor neutrino experiments are included. The search for tau neutrino appearance from neutrino oscillations has resulted in a 4.6σ exclusion of the hypothesis of no tau appearance. Hyper-Kamiokande is a proposed next-generation water Cherenkov detector, which will be a natural extension of Super-Kamiokande. The proposed experiment will have two cylindrical tanks containing 520 kton of water in total. Hyper-K will search for CP violation using the neutrino beam from J-PARC, and will have a broad physics program including studies of atmospheric neutrinos, supernova burst neutrinos, geo-neutrinos and searches for proton decay.

Search for sterile neutrino mixing in the muon neutrino to tau neutrino appearance channel with the OPERA detector

NASA Astrophysics Data System (ADS)

Di Crescenzo, A.; OPERA Collaboration

2016-05-01

The OPERA experiment observed ν μ → ν τ oscillations in the atmospheric sector. To this purpose the hybrid OPERA detector was exposed to the CERN Neutrinos to Gran Sasso beam from 2008 to 2012, at a distance of 730 km from the neutrino source. Charged-current interactions of ν τ were searched for through the identification of τ lepton decay topologies. The five observed ν τ interactions are consistent with the expected number of events in the standard three neutrino framework. Based on this result, new limits on the mixing parameters of a massive sterile neutrino may be set. Preliminary results of the analysis performed in the 3+1 neutrino framework are here presented.

Black holes at neutrino telescopes

NASA Astrophysics Data System (ADS)

Kowalski, M.; Ringwald, A.; Tu, H.

2002-03-01

In scenarios with extra dimensions and TeV-scale quantum gravity, black holes are expected to be produced in the collision of light particles at center-of-mass energies above the fundamental Planck scale with small impact parameters. Black hole production and evaporation may thus be studied in detail at the Large Hadron Collider (LHC). But even before the LHC starts operating, neutrino telescopes such as AMANDA/IceCube, ANTARES, Baikal, and RICE have an opportunity to search for black hole signatures. Black hole production in the scattering of ultrahigh energy cosmic neutrinos on nucleons in the ice or water may initiate cascades and through-going muons with distinct characteristics above the Standard Model rate. In this Letter, we investigate the sensitivity of neutrino telescopes to black hole production and compare it to the one expected at the Pierre Auger Observatory, an air shower array currently under construction, and at the LHC. We find that, already with the currently available data, AMANDA and RICE should be able to place sensible constraints in black hole production parameter space, which are competitive with the present ones from the air shower facilities Fly's Eye and AGASA. In the optimistic case that a ultrahigh energy cosmic neutrino flux significantly higher than the one expected from cosmic ray interactions with the cosmic microwave background radiation is realized in nature, one even has discovery potential for black holes at neutrino telescopes beyond the reach of LHC.

Measurement of horizontal air showers with the Auger Engineering Radio Array

NASA Astrophysics Data System (ADS)

Kambeitz, Olga

2017-03-01

The Auger Engineering Radio Array (AERA), at the Pierre Auger Observatory in Argentina, measures the radio emission of extensive air showers in the 30-80 MHz frequency range. AERA consists of more than 150 antenna stations distributed over 17 km2. Together with the Auger surface detector, the fluorescence detector and the underground muon detector (AMIGA), AERA is able to measure cosmic rays with energies above 1017 eV in a hybrid detection mode. AERA is optimized for the detection of air showers up to 60° zenith angle, however, using the reconstruction of horizontal air showers with the Auger surface array, very inclined showers can also be measured. In this contribution an analysis of the AERA data in the zenith angle range from 62° to 80° will be presented. CoREAS simulations predict radio emission footprints of several km2 for horizontal air showers, which are now confirmed by AERA measurements. This can lead to radio-based composition measurements and energy determination of horizontal showers in the future and the radio detection of neutrino induced showers is possible.

Radiative decay of massious neutrinos: Implications for physics and astrophysics

NASA Technical Reports Server (NTRS)

Stecker, F. W.

1981-01-01

The radiative lifetime tau for the decay of massious neutrinos is calculated using various physical models for neutrino decay. The results are related to the astrophysical problem of the detectability of the decay photons from cosmic neutrinos. Conversely, the astrophysical data are used to place lower limits on tau. However, an observed feature at approximately 1700 A in the ultraviolet background radiation at high galactic latitudes may be from the decay of neutrinos with mass approximately 14 eV. This would require a decay rate much larger than the predictions of standard models but could be indicative of a decay rate possible in composite models. It is considered that this may be an important test for substructure in leptons and quarks.

All flavour point-source search with the ANTARES neutrino telescope

NASA Astrophysics Data System (ADS)

Michael, Tino

2017-09-01

ANTARES is the largest neutrino telescope in the Northern Hemisphere. The detector has established excellent pointing resolution for muon neutrinos (0.4 degrees) and a degree-level resolution also for contained shower events (about 2 degrees). Together with its geographical location, the good angular resolution makes ANTARES an excellent tool to test for the presence of cosmic sources in the Southern Hemisphere and in particular the area around the Galactic Centre, where IceCube reports a number of high-energy events. In this contribution, we present a search for cosmic neutrino sources using ANTARES data taken from early 2007 until the end of 2013. Such sources are identified as a cluster of events in the combined track and shower channels. In addition to the all-flavour full-sky and candidate list searches, we focus on a restricted region around the Galactic Centre. Different spectral indices for the neutrino energy spectrum have been investigated as well as possible extended sources.

Friedberg-Lee symmetry and tribimaximal neutrino mixing in the inverse seesaw mechanism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chan, A.H.; Institute of Advanced Studies, Nanyang Technological University, Singapore 639673; Department of Physics, National University of Singapore, Singapore 117542

2009-10-01

The inverse seesaw mechanism with three pairs of gauge-singlet neutrinos offers a natural interpretation of the tiny masses of three active neutrinos at the TeV scale. We combine this picture with the newly proposed Friedberg-Lee (FL) symmetry in order to understand the observed pattern of neutrino mixing. We show that the FL symmetry requires only two pairs of the gauge-singlet neutrinos to be massive, implying that one active neutrino must be massless. We propose a phenomenological ansatz with broken FL symmetry and exact {mu}-{tau} symmetry in the gauge-singlet neutrino sector, and obtain the tribimaximal neutrino mixing pattern by means ofmore » the inverse seesaw relation. We demonstrate that nonunitary corrections to this result can possibly reach the percent level, and a soft breaking of {mu}-{tau} symmetry can give rise to CP violation in such a TeV-scale seesaw scenario.« less

Mu- and Tau-Neutrino Spectra Formation in Supernovae

NASA Astrophysics Data System (ADS)

Raffelt, Georg G.

2001-11-01

The μ- and τ-neutrinos emitted from a proto-neutron star are produced by nucleonic bremsstrahlung NN-->NNνν and pair annihilation e+e--->νν, reactions that freeze out at the ``energy sphere.'' Before escaping from there to infinity, the neutrinos diffuse through the ``scattering atmosphere,'' a layer in which their main interaction is elastic scattering on nucleons νN-->Nν. If these collisions are taken to be isoenergetic, as in all numerical supernova simulations, the neutrino flux spectrum escaping to infinity depends only on the medium temperature TES and the thermally averaged optical depth τES at the energy sphere. For τES=10-50, one finds for the spectral flux temperature of the escaping neutrinos Tflux=0.5-0.6TES. Including energy exchange (nucleon recoil) in νN-->Nν can shift Tflux both up and down. ΔTflux depends on τES, on the scattering atmosphere's temperature profile, and on TES. Based on a numerical study, we find that for typical conditions, ΔTflux/Tflux is between -10% and -20% and even for extreme parameter choices does not exceed -30%. The exact value of ΔTflux/Tflux is surprisingly insensitive to the assumed value of the nucleon mass; i.e., the exact efficiency of energy transfer between neutrinos and nucleons is not important as long as it can occur at all. Therefore, calculating the νμ and ντ spectra does not seem to require a precise knowledge of the nuclear medium's dynamical structure functions.

Acceptances for space-based and ground-based fluorescence detectors, and inference of the neutrino-nucleon cross-section above 1019eV

NASA Astrophysics Data System (ADS)

Palomares-Ruiz, Sergio; Irimia, Andrei; Weiler, Thomas J.

2006-04-01

Detection of ultrahigh energy neutrinos will be useful for unraveling the dynamics of the most violent sources in the cosmos and for revealing the neutrino cross-section at extreme energy. If there exists a Greisen-Zatsepin-Kuz’min (GZK) suppression of cosmic-ray events above EGZK˜5×1019eV, as predicted by theory, then the only messengers of energies beyond EGZK are neutrinos. Cosmic neutrino fluxes can initiate air-showers through interaction in the atmosphere, or in the Earth. Neutrino trajectories will be downgoing to nearly horizontal in the former case, and “Earth-skimming” in the latter case. Thus it is important to know the acceptances (event rate/flux) of proposed air-shower experiments for detecting both types of neutrino-initiated events. We calculate these acceptances for fluorescence detectors, both space-based as with the EUSO and OWL proposals, and ground-based, as with Auger, HiRes and Telescope Array. The neutrino cross-section σνNCC is unknown at energies above 5.2×1013eV. Although the popular QCD extrapolation of lower-energy physics offers the cross-section value of 0.54×10-31(Eν/1020eV)0.36cm2, new physics could raise or lower this value. Therefore, we present the acceptances of horizontal (HAS) and upgoing (UAS) air-showers as a function of σνNCC over the range 10-34 to 10-30cm2. The dependences of acceptances on neutrino energy, shower-threshold energy, shower length, and shower column density are also studied. We introduce a cloud layer, and study its effect on rates as viewed from space and from the ground. For UAS, we present acceptances for events over land (rock), and over the ocean (water). Acceptances over water are larger by about an order of magnitude, thus favoring space-based detectors. We revisit the idea of Kusenko and Weiler [Phys. Rev. Lett. 88, 161101 (2002)PRLTAO0031-900710.1103/PhysRevLett.88.161101] to infer σνNCC at Eν≳1020 from the ratio of HAS-to-UAS events, and obtain favorable results. Included in

Neutrino Observations from the Sudbury Neutrino Observatory

DOE R&D Accomplishments Database

Q. R. Ahmad, R. C. Allen, T. C. Andersen, J. D. Anglin, G. B?hler, J. C. Barton, E. W. Beier, M. Bercovitch, J. Bigu, S. Biller, R. A. Black, I. Blevis, R. J. Boardman, J. Boger, E. Bonvin, M. G. Boulay, M. G. Bowler, T. J. Bowles, S. J. Brice, M. C. Browne, T. V. Bullard, T. H. Burritt, K. Cameron, J. Cameron, Y. D. Chan, M. Chen, H. H. Chen, X. Chen, M. C. Chon, B. T. Cleveland, E. T. H. Clifford, J. H. M. Cowan, D. F. Cowen, G. A. Cox, Y. Dai, X. Dai, F. Dalnoki-Veress, W. F. Davidson, P. J. Doe, G. Doucas, M. R. Dragowsky, C. A. Duba, F. A. Duncan, J. Dunmore, E. D. Earle, S. R. Elliott, H. C. Evans, G. T. Ewan, J. Farine, H. Fergani, A. P. Ferraris, R. J. Ford, M. M. Fowler, K. Frame, E. D. Frank, W. Frati, J. V. Germani, S. Gil, A. Goldschmidt, D. R. Grant, R. L. Hahn, A. L. Hallin, E. D. Hallman, A. Hamer, A. A. Hamian, R. U. Haq, C. K. Hargrove, P. J. Harvey, R. Hazama, R. Heaton, K. M. Heeger, W. J. Heintzelman, J. Heise, R. L. Helmer, J. D. Hepburn, H. Heron, J. Hewett, A. Hime, M. Howe, J. G. Hykawy, M. C. P. Isaac, P. Jagam, N. A. Jelley, C. Jillings, G. Jonkmans, J. Karn, P. T. Keener, K. Kirch, J. R. Klein, A. B. Knox, R. J. Komar, R. Kouzes, T. Kutter, C. C. M. Kyba, J. Law, I. T. Lawson, M. Lay, H. W. Lee, K. T. Lesko, J. R. Leslie, I. Levine, W. Locke, M. M. Lowry, S. Luoma, J. Lyon, S. Majerus, H. B. Mak, A. D. Marino, N. McCauley, A. B. McDonald, D. S. McDonald, K. McFarlane, G. McGregor, W. McLatchie, R. Meijer Drees, H. Mes, C. Mifflin, G. G. Miller, G. Milton, B. A. Moffat, M. Moorhead, C. W. Nally, M. S. Neubauer, F. M. Newcomer, H. S. Ng, A. J. Noble, E. B. Norman, V. M. Novikov, M. O'Neill, C. E. Okada, R. W. Ollerhead, M. Omori, J. L. Orrell, S. M. Oser, A. W. P. Poon, T. J. Radcliffe, A. Roberge, B. C. Robertson, R. G. H. Robertson, J. K. Rowley, V. L. Rusu, E. Saettler, K. K. Schaffer, A. Schuelke, M. H. Schwendener, H. Seifert, M. Shatkay, J. J. Simpson, D. Sinclair, P. Skensved, A. R. Smith, M. W. E. Smith, N. Starinsky, T. D. Steiger, R. G. Stokstad, R. S. Storey, B. Sur, R. Tafirout, N. Tagg, N. W. Tanner, R. K. Taplin, M. Thorman, P. Thornewell, P. T. Trent, Y. I. Tserkovnyak, R. Van Berg, R. G. Van de Water, C. J. Virtue, C. E. Waltham, J.-X. Wang, D. L. Wark, N. West, J. B. Wilhelmy, J. F. Wilkerson, J. Wilson, P. Wittich, J. M. Wouters, and M. Yeh

2001-09-24

The Sudbury Neutrino Observatory (SNO) is a water imaging Cherenkov detector. Its usage of 1000 metric tons of D{sub 2}O as target allows the SNO detector to make a solar-model independent test of the neutrino oscillation hypothesis by simultaneously measuring the solar {nu}{sub e} flux and the total flux of all active neutrino species. Solar neutrinos from the decay of {sup 8}B have been detected at SNO by the charged-current (CC) interaction on the deuteron and by the elastic scattering (ES) of electrons. While the CC reaction is sensitive exclusively to {nu}{sub e}, the ES reaction also has a small sensitivity to {nu}{sub {mu}} and {nu}{sub {tau}}. In this paper, recent solar neutrino results from the SNO experiment are presented. It is demonstrated that the solar flux from {sup 8}B decay as measured from the ES reaction rate under the no-oscillation assumption is consistent with the high precision ES measurement by the Super-Kamiokande experiment. The {nu}{sub e} flux deduced from the CC reaction rate in SNO differs from the Super-Kamiokande ES results by 3.3{sigma}. This is evidence for an active neutrino component, in additional to {nu}{sub e}, in the solar neutrino flux. These results also allow the first experimental determination of the total active {sup 8}B neutrino flux from the Sun, and is found to be in good agreement with solar model predictions.

Flavor Composition of the High-Energy Neutrino Events in IceCube

NASA Astrophysics Data System (ADS)

Mena, Olga; Palomares-Ruiz, Sergio; Vincent, Aaron C.

2014-08-01

The IceCube experiment has recently reported the observation of 28 high-energy (>30 TeV) neutrino events, separated into 21 showers and 7 muon tracks, consistent with an extraterrestrial origin. In this Letter, we compute the compatibility of such an observation with possible combinations of neutrino flavors with relative proportion (αe∶αμ∶ατ)⊕. Although the 7∶21 track-to-shower ratio is naively favored for the canonical (1∶1∶1)⊕ at Earth, this is not true once the atmospheric muon and neutrino backgrounds are properly accounted for. We find that, for an astrophysical neutrino E-2 energy spectrum, (1∶1∶1)⊕ at Earth is disfavored at 81% C.L. If this proportion does not change, 6 more years of data would be needed to exclude (1∶1∶1)⊕ at Earth at 3σ C.L. Indeed, with the recently released 3-yr data, that flavor composition is excluded at 92% C.L. The best fit is obtained for (1∶0∶0)⊕ at Earth, which cannot be achieved from any flavor ratio at sources with averaged oscillations during propagation. If confirmed, this result would suggest either a misunderstanding of the expected background events or a misidentification of tracks as showers, or even more compellingly, some exotic physics which deviates from the standard scenario.

Observation of tau neutrino appearance in the CNGS beam with the OPERA experiment

NASA Astrophysics Data System (ADS)

Opera Collaboration; Agafonova, N.; Aleksandrov, A.; Anokhina, A.; Aoki, S.; Ariga, A.; Ariga, T.; Asada, T.; Bender, D.; Bertolin, A.; Bozza, C.; Brugnera, R.; Buonaura, A.; Buontempo, S.; Büttner, B.; Chernyavsky, M.; Chukanov, A.; Consiglio, L.; D'Ambrosio, N.; de Lellis, G.; de Serio, M.; Del Amo Sanchez, P.; di Crescenzo, A.; di Ferdinando, D.; di Marco, N.; Dmitrievski, S.; Dracos, M.; Duchesneau, D.; Dusini, S.; Dzhatdoev, T.; Ebert, J.; Ereditato, A.; Fini, R. A.; Fukuda, T.; Galati, G.; Garfagnini, A.; Giacomelli, G.; Goellnitz, C.; Goldberg, J.; Gornushkin, Y.; Grella, G.; Guler, M.; Gustavino, C.; Hagner, C.; Hara, T.; Hayakawa, T.; Hollnagel, A.; Hosseini, B.; Ishida, H.; Ishiguro, K.; Jakovcic, K.; Jollet, C.; Kamiscioglu, C.; Kamiscioglu, M.; Katsuragawa, T.; Kawada, J.; Kawahara, H.; Kim, J. H.; Kim, S. H.; Kitagawa, N.; Klicek, B.; Kodama, K.; Komatsu, M.; Kose, U.; Kreslo, I.; Lauria, A.; Lenkeit, J.; Ljubicic, A.; Longhin, A.; Loverre, P.; Malenica, M.; Malgin, A.; Mandrioli, G.; Matsuo, T.; Matveev, V.; Mauri, N.; Medinaceli, E.; Meregaglia, A.; Meyer, M.; Mikado, S.; Miyanishi, M.; Monacelli, P.; Montesi, M. C.; Morishima, K.; Muciaccia, M. T.; Naganawa, N.; Naka, T.; Nakamura, M.; Nakano, T.; Nakatsuka, Y.; Niwa, K.; Ogawa, S.; Okateva, N.; Olshevsky, A.; Omura, T.; Ozaki, K.; Paoloni, A.; Park, B. D.; Park, I. G.; Pasqualini, L.; Pastore, A.; Patrizii, L.; Pessard, H.; Pistillo, C.; Podgrudkov, D.; Polukhina, N.; Pozzato, M.; Pupilli, F.; Roda, M.; Roganova, T.; Rokujo, H.; Rosa, G.; Ryazhskaya, O.; Sato, O.; Schembri, A.; Shakiryanova, I.; Shchedrina, T.; Sheshukov, A.; Shibuya, H.; Shiraishi, T.; Shoziyoev, G.; Simone, S.; Sioli, M.; Sirignano, C.; Sirri, G.; Spinetti, M.; Stanco, L.; Starkov, N.; Stellacci, S. M.; Stipcevic, M.; Strolin, P.; Takahashi, S.; Tenti, M.; Terranova, F.; Tioukov, V.; Tufanli, S.; Umemoto, A.; Vilain, P.; Vladimirov, M.; Votano, L.; Vuilleumier, J. L.; Wilquet, G.; Wonsak, B.; Yoon, C. S.; Yaguchi, I.; Yoshimoto, M.; Zemskova, S.; Zghiche, A.

2014-10-01

The OPERA experiment is searching for ν _μ rArr ν _tau oscillations in appearance mode, i.e., via the direct detection of tau leptons in ν _tau charged-current interactions. The evidence of ν _μ rArr ν _tau appearance has been previously reported with three ν _tau candidate events using a sub-sample of data from the 2008-2012 runs. We report here a fourth ν _tau candidate event, with the tau decaying into a hadron, found after adding the 2012 run events without any muon in the final state to the data sample. Given the number of analyzed events and the low background, ν _μ rArr ν _tau oscillations are established with a significance of 4.2σ.

Flavour-symmetric type-II Dirac neutrino seesaw mechanism

NASA Astrophysics Data System (ADS)

Bonilla, Cesar; Lamprea, J. M.; Peinado, Eduardo; Valle, Jose W. F.

2018-04-01

We propose a Standard Model extension with underlying A4 flavour symmetry where small Dirac neutrino masses arise from a Type-II seesaw mechanism. The model predicts the "golden" flavour-dependent bottom-tau mass relation, requires an inverted neutrino mass ordering and non-maximal atmospheric mixing angle. Using the latest neutrino oscillation global fit [1] we derive restrictions on the oscillation parameters, such as a correlation between δCP and mνlightest.

Astrophysical tests for radiative decay of neutrinos and fundamental physics implications

NASA Technical Reports Server (NTRS)

Stecker, F. W.; Brown, R. W.

1981-01-01

The radiative lifetime tau for the decay of massious neutrinos was calculated using various physical models for neutrino decay. The results were then related to the astrophysical problem of the detectability of the decay photons from cosmic neutrinos. Conversely, the astrophysical data were used to place lower limits on tau. These limits are all well below predicted values. However, an observed feature at approximately 1700 A in the ultraviolet background radiation at high galactic latitudes may be from the decay of neutrinos with mass approximately 14 eV. This would require a decay rate much larger than the predictions of standard models but could be indicative of a decay rate possible in composite models or other new physics. Thus an important test for substructure in leptons and quarks or other physics beyond the standard electroweak model may have been found.

Dirac neutrinos and SN 1987A

NASA Technical Reports Server (NTRS)

Turner, Michael S.

1991-01-01

Previous work has shown that the cooling of SN 1987A excludes a Dirac-neutrino mass greater than theta(20 keV) for nu(sub e), nu(sub mu), or nu(sub tau). The emission of wrong-helicity, Dirac neutrinos from SN 1987A, is re-examined. It is concluded that the effect of a Dirac neutrino on the cooling of SN 1987A has been underestimated due to neutrino degeneracy and additional emission processes. The limit that follows from the cooling of SN 1987A is believed to be greater (probably much greater) than 10 keV. This result is significant in light of the recent evidence for a 17 keV mass eigenstate that mixes with the electron neutrino.

Spallation backgrounds in Super-Kamiokande are made in muon-induced showers

NASA Astrophysics Data System (ADS)

Li, Shirley Weishi; Beacom, John F.

2015-05-01

Crucial questions about solar and supernova neutrinos remain unanswered. Super-Kamiokande has the exposure needed for progress, but detector backgrounds are a limiting factor. A leading component is the beta decays of isotopes produced by cosmic-ray muons and their secondaries, which initiate nuclear spallation reactions. Cuts of events after and surrounding muon tracks reduce this spallation decay background by ≃ 90 % (at a cost of ≃ 20 % deadtime), but its rate at 6-18 MeV is still dominant. A better way to cut this background was suggested in a Super-Kamiokande paper by Bays et al. [Phys. Rev. D 85, 052007 (2012)] on a search for the diffuse supernova neutrino background. They found that spallation decays above 16 MeV were preceded near the same location by a peak in the apparent Cherenkov light profile from the muon; a more aggressive cut was applied to a limited section of the muon track, leading to decreased background without increased deadtime. We put their empirical discovery on a firm theoretical foundation. We show that almost all spallation decay isotopes are produced by muon-induced showers and that these showers are rare enough and energetic enough to be identifiable. This is the first such demonstration for any detector. We detail how the physics of showers explains the peak in the muon Cherenkov light profile and other Super-K observations. Our results provide a physical basis for practical improvements in background rejection that will benefit multiple studies. For solar neutrinos, in particular, it should be possible to dramatically reduce backgrounds at energies as low as 6 MeV.

IceVeto: Extended PeV neutrino astronomy in the Southern Hemisphere with IceCube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Auffenberg, Jan; Collaboration: IceCube Collaboration

IceCube, the world's largest high-energy neutrino observatory, built at the South Pole, recently reported evidence of an astrophysical neutrino flux extending to PeV energies in the Southern Hemisphere. This observation raises the question of how the sensitivity in this energy range could be further increased. In the down-going sector, in IceCube's case the Southern Hemisphere, backgrounds from atmospheric muons and neutrinos pose a challenge to the identification of an astrophysical neutrino flux. The IceCube analysis, that led to the evidence for astrophysical neutrinos, is based on an in-ice veto strategy for background rejection. One possibility available to IceCube is themore » concept of an extended surface detector, IceVeto, which could allow the rejection of a large fraction of atmospheric backgrounds, primarily for muons from cosmic ray (CR) air showers as well as from neutrinos in the same air showers. Building on the experience of IceTop/IceCube, possibly the most cost-effective and sensitive way to build IceVeto is as an extension of the IceTop detector, with simple photomultiplier based detector modules for CR air shower detection. Initial simulations and estimates indicate that such a veto detector will significantly increase the sensitivity to an astrophysical flux of ν{sub μ} induced muon tracks in the Southern Hemisphere compared to current analyses. Here we present the motivation and capabilities based on initial simulations. Conceptual ideas for a simplified surface array will be discussed briefly.« less

Salt Neutrino Detector for Ultrahigh-Energy Neutrinos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chiba, M.; Yasuda, O.; Kamijo, T.

2004-11-01

Rock salt and limestone are studied to determine their suitability for use as a radio-wave transmission medium in an ultrahigh energy (UHE) cosmic neutrino detector. A sensible radio wave would be emitted by the coherent Cherenkov radiation from negative excess charges inside an electromagnetic shower upon interaction of a UHE neutrino in a high-density medium (Askar'yan effect). If the attenuation length for the radio wave in the material is large, a relatively small number of radio-wave sensors could detect the interaction occurring in the massive material. We measured the complex permittivity of the rock salt and limestone by the perturbedmore » cavity resonator method at 9.4 and 1 GHz to good precision. We obtained new results of measurements at the frequency at 1.0 GHz. The measured value of the radio-wave attenuation length of synthetic rock salt samples is 1080 m. The samples from the Hockley salt mine in the United States show attenuation length of 180 m at 1 GHz, and then we estimate it by extrapolation to be as long as 900 m at 200 MHz. The results show that there is a possibility of utilizing natural massive deposits of rock salt for a UHE neutrino detector. A salt neutrino detector with a size of 2 x 2 x 2 km would detect 10 UHE neutrino/yr generated through the GZK process.« less

Search for ultrahigh energy neutrinos in highly inclined events at the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Abreu, P.; Aglietta, M.; Ahn, E. J.; Albuquerque, I. F. M.; Allard, D.; Allekotte, I.; Allen, J.; Allison, P.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Antičić, T.; Anzalone, A.; Aramo, C.; Arganda, E.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Bäcker, T.; Balzer, M.; Barber, K. B.; Barbosa, A. F.; Bardenet, R.; Barroso, S. L. C.; Baughman, B.; Bäuml, J.; Beatty, J. J.; Becker, B. R.; Becker, K. H.; Bellétoile, A.; Bellido, J. A.; Benzvi, S.; Berat, C.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brogueira, P.; Brown, W. C.; Bruijn, R.; Buchholz, P.; Bueno, A.; Burton, R. E.; Caballero-Mora, K. S.; Caramete, L.; Caruso, R.; Castellina, A.; Catalano, O.; Cataldi, G.; Cazon, L.; Cester, R.; Chauvin, J.; Cheng, S. H.; Chiavassa, A.; Chinellato, J. A.; Chou, A.; Chudoba, J.; Clay, R. W.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cook, H.; Cooper, M. J.; Coppens, J.; Cordier, A.; Coutu, S.; Covault, C. E.; Creusot, A.; Criss, A.; Cronin, J.; Curutiu, A.; Dagoret-Campagne, S.; Dallier, R.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Domenico, M.; de Donato, C.; de Jong, S. J.; de La Vega, G.; de Mello Junior, W. J. M.; de Mello Neto, J. R. T.; de Mitri, I.; de Souza, V.; de Vries, K. D.; Decerprit, G.; Del Peral, L.; Del Río, M.; Deligny, O.; Dembinski, H.; Dhital, N.; di Giulio, C.; Diaz, J. C.; Díaz Castro, M. L.; Diep, P. N.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; Dos Anjos, J. C.; Dova, M. T.; D'Urso, D.; Dutan, I.; Ebr, J.; Engel, R.; Erdmann, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Facal San Luis, P.; Fajardo Tapia, I.; Falcke, H.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Ferrero, A.; Fick, B.; Filevich, A.; Filipčič, A.; Fliescher, S.; Fracchiolla, C. E.; Fraenkel, E. D.; Fröhlich, U.; Fuchs, B.; Gaior, R.; Gamarra, R. F.; Gambetta, S.; García, B.; García Gámez, D.; Garcia-Pinto, D.; Gascon, A.; Gemmeke, H.; Gesterling, K.; Ghia, P. L.; Giaccari, U.; Giller, M.; Glass, H.; Gold, M. S.; Golup, G.; Gomez Albarracin, F.; Gómez Berisso, M.; Gonçalves, P.; Gonzalez, D.; Gonzalez, J. G.; Gookin, B.; Góra, D.; Gorgi, A.; Gouffon, P.; Gozzini, S. R.; Grashorn, E.; Grebe, S.; Griffith, N.; Grigat, M.; Grillo, A. F.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Guzman, A.; Hague, J. D.; Hansen, P.; Harari, D.; Harmsma, S.; Harrison, T. A.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Herve, A. E.; Hojvat, C.; Hollon, N.; Holmes, V. C.; Homola, P.; Hörandel, J. R.; Horneffer, A.; Horvath, P.; Hrabovský, M.; Huege, T.; Insolia, A.; Ionita, F.; Italiano, A.; Jarne, C.; Jiraskova, S.; Josebachuili, M.; Kadija, K.; Kampert, K. H.; Karhan, P.; Kasper, P.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kelley, J. L.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Knapp, J.; Koang, D.-H.; Kotera, K.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuehn, F.; Kuempel, D.; Kulbartz, J. K.; Kunka, N.; Rosa, G.; Lachaud, C.; Lautridou, P.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Lemiere, A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Lopez Agüera, A.; Louedec, K.; Lozano Bahilo, J.; Lu, L.; Lucero, A.; Ludwig, M.; Lyberis, H.; Maccarone, M. C.; Macolino, C.; Maldera, S.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, J.; Marin, V.; Maris, I. C.; Marquez Falcon, H. R.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Martínez Bravo, O.; Mathes, H. J.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurizio, D.; Mazur, P. O.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Mertsch, P.; Meurer, C.; Mićanović, S.; Micheletti, M. I.; Miller, W.; Miramonti, L.; Molina-Bueno, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morales, B.; Morello, C.; Moreno, E.; Moreno, J. C.; Morris, C.; Mostafá, M.; Moura, C. A.; Mueller, S.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Neuser, J.; Newton, D.; Nhung, P. T.; Niemietz, L.; Nierstenhoefer, N.; Nitz, D.; Nosek, D.; Nožka, L.; Nyklicek, M.; Oehlschläger, J.; Olinto, A.; Oliva, P.; Olmos-Gilbaja, V. M.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Parente, G.; Parizot, E.; Parra, A.; Parsons, R. D.; Pastor, S.; Paul, T.; Pech, M.; Pȩkala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Petrera, S.; Petrinca, P.; Petrolini, A.; Petrov, Y.; Petrovic, J.; Pfendner, C.; Phan, N.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Ponce, V. H.; Pontz, M.; Privitera, P.; Prouza, M.; Quel, E. J.; Querchfeld, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rivera, H.; Rizi, V.; Roberts, J.; Robledo, C.; Rodrigues de Carvalho, W.; Rodriguez, G.; Rodriguez Martino, J.; Rodriguez Rojo, J.; Rodriguez-Cabo, I.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Rouillé-D'Orfeuil, B.; Roulet, E.; Rovero, A. C.; Rühle, C.; Salamida, F.; Salazar, H.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarkar, S.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Schmidt, F.; Scholten, O.; Schoorlemmer, H.; Schovancova, J.; Schovánek, P.; Schröder, F.; Schulte, S.; Schuster, D.; Sciutto, S. J.; Scuderi, M.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Silva Lopez, H. H.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Spinka, H.; Squartini, R.; Stanic, S.; Stapleton, J.; Stasielak, J.; Stephan, M.; Strazzeri, E.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Šuša, T.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Tamashiro, A.; Tapia, A.; Tartare, M.; Taşcău, O.; Tavera Ruiz, C. G.; Tcaciuc, R.; Tegolo, D.; Thao, N. T.; Thomas, D.; Tiffenberg, J.; Timmermans, C.; Tiwari, D. K.; Tkaczyk, W.; Todero Peixoto, C. J.; Tomé, B.; Tonachini, A.; Travnicek, P.; Tridapalli, D. B.; Tristram, G.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van den Berg, A. M.; Varela, E.; Vargas Cárdenas, B.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Wahlberg, H.; Wahrlich, P.; Wainberg, O.; Walz, D.; Warner, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Westerhoff, S.; Whelan, B. J.; Wieczorek, G.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Winnick, M. G.; Wommer, M.; Wundheiler, B.; Yamamoto, T.; Yapici, T.; Younk, P.; Yuan, G.; Yushkov, A.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Zimbres Silva, M.; Ziolkowski, M.

2011-12-01

The Surface Detector of the Pierre Auger Observatory is sensitive to neutrinos of all flavors above 0.1 EeV. These interact through charged and neutral currents in the atmosphere giving rise to extensive air showers. When interacting deeply in the atmosphere at nearly horizontal incidence, neutrinos can be distinguished from regular hadronic cosmic rays by the broad time structure of their shower signals in the water-Cherenkov detectors. In this paper we present for the first time an analysis based on down-going neutrinos. We describe the search procedure, the possible sources of background, the method to compute the exposure and the associated systematic uncertainties. No candidate neutrinos have been found in data collected from 1 January 2004 to 31 May 2010. Assuming an E-2 differential energy spectrum the limit on the single-flavor neutrino is E2dN/dE<1.74×10-7GeVcm-2s-1sr-1 at 90% C.L. in the energy range 1×1017eV

Event identification for KM3NeT/ARCA

NASA Astrophysics Data System (ADS)

Heid, Thomas; KM3NeT Collaboration

2017-09-01

KM3NeT is a large research infrastructure consisting of a network of deep-sea neutrino telescopes. KM3NeT/ARCA will be the instrument detecting high-energy neutrinos with energies above 100 TeV. This instrument gives a new opportunity to observe the neutrino sky with very high angular resolution to be able to detect neutrino point sources. Furthermore it will be possible to probe the flavour composition of neutrino fluxes, and hence production mechanisms, with so-far unreached precision. Neutrinos produce different event topologies in the detector according to their flavour, interaction channel and deposited energy. Machine-learning algorithms are able to learn features of topologies to discriminate them. In previous analyses only two event types were regarded, namely the shower and track topology. With good timing resolution and precise reconstruction algorithms it is possible to separate into more event types, for example the double bang topology produced by tau neutrinos. The final goal is to distinguish all three neutrino flavors as much as possible. To resolve this issue the KM3NeT collaboration uses deep neural networks trained with Monte Carlo events of all neutrino types. This contribution shows the ability of KM3NeT/ARCA to classify events in more than two neutrino event topologies. Furthermore, the borders between detectable classes are shown, such as the minimum distance the tau has to travel before decaying into a tau neutrino to be detected as double bang event.

Overview and Status of Experimental Neutrino Physics

NASA Astrophysics Data System (ADS)

Stancu, Ion

2002-10-01

Seventy years after the existence of the neutrino has been postulated by Wolfgang Pauli, these elusive particles remain surrounded by mystery. One of the most fundamental questions about neutrinos is whether they have an identically vanishing mass, as assumed by the Standard Model, or not. Direct measurements have proven to be extremely difficult to perform, and have yielded so far only upper limits. However, if neutrino flavour oscillations do happen, this would automatically imply that at least one of the three neutrinos (the electron, muon or tau neutrino) must have a non-zero mass. The present experimental data indicate that both the solar and atmospheric neutrino deficits can be explained by the phenomenon of neutrino oscillations, while the positive signal reported by the accelerator-based LSND experiment remains to be verified by an independent measurement (MiniBooNE). This talk reviews the current status of the neutrino oscillations experiments, experiments which are quite likely to produce results with significant consequences for both the Standard Model and Cosmology.

E sub 6 leptoquarks and the solar neutrino problem

NASA Technical Reports Server (NTRS)

Roulet, Esteban

1991-01-01

The possibility that non-conventional neutrino oscillations take place in the superstring inspired E sub 6 models is considered. In this context, the influence of leptoquark mediated interactions of the neutrinos with nucleons in the resonant flavor conversion is discussed. It is shown that this effect can be significant for v sub e - v sub tau oscillations if these neutrinos have masses required in the ordinary Mikheyev-Smirnov-Wolfenstein (MSW) effect, and may lead to a solution of the solar neutrino problem even in the absence of vacuum mixings. On the other hand, this model cannot lead to a resonant behavior in the sun if the neutrinos are massless.

Right-Handed Neutrinos and the 2 TeV $W'$ Boson

DOE PAGES

Coloma, Pilar; Dobrescu, Bogdan A.; Lopez-Pavon, Jacobo

2015-12-30

The CMS e +e -jj events of invariant mass near 2 TeV are consistent with a W' boson decaying into an electron and a right-handed neutrino whose TeV-scale mass is of the Dirac type. We show that the Dirac partner of the right-handed electron-neutrino can be the right-handed tau-neutrino. Furthermore, a prediction of this model is that the sum of the τ +e +jj and τ -e -jj signal cross sections equals twice that for e +e -jj. The Standard Model neutrinos acquire Majorana masses and mixings compatible with neutrino oscillation data.

Search for ultra high energy astrophysical neutrinos with the ANITA experiment

NASA Astrophysics Data System (ADS)

Romero-Wolf, Andrew

2010-12-01

This work describes a search for cosmogenic neutrinos at energies above 1018 eV with the Antarctic Impulsive Transient Antenna (ANITA). ANITA is a balloon-borne radio interferometer designed to measure radio impulsive emission from particle showers produced in the Antarctic ice-sheet by ultra-high energy neutrinos (UHEnu). Flying at 37 km altitude the ANITA detector is sensitive to 1M km3 of ice and is expected to produce the highest exposure to ultra high energy neutrinos to date. The design, flight performance, and analysis of the first flight of ANITA in 2006 are the subject of this dissertation. Due to sparse anthropogenic backgrounds throughout the Antarctic continent, the ANITA analysis depends on high resolution directional reconstruction. An interferometric method was developed that not only provides high resolution but is also sensitive to very weak radio emissions. The results of ANITA provide the strongest constraints on current ultra-high energy neutrino models. In addition there was a serendipitous observation of ultra-high energy cosmic ray geosynchrotron emissions that are of distinct character from the expected neutrino signal. This thesis includes a study of the radio Cherenkov emission from ultra-high energy electromagnetic showers in ice in the time-domain. All previous simulations computed the radio pulse frequency spectrum. I developed a purely time-domain algorithm for computing radiation using the vector potentials of charged particle tracks. The results are fully consistent with previous frequency domain calculations and shed new light into the properties of the radio pulse in the time domain. The shape of the pulse in the time domain is directly related to the depth development of the excess charge in the shower and its width to the observation angle with respect to the Cherenkov direction. This information can be of great practical importance for interpreting actual data.

Search for third-generation scalar leptoquarks and heavy right-handed neutrinos in final states with two tau leptons and two jets in proton-proton collisions at $$ \\sqrt{s}=13 $$ TeV

DOE PAGES

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; ...

2017-07-26

A search is performed for third-generation scalar leptoquarks and heavy right-handed neutrinos in events containing one electron or muon, one hadronically decaying τ lepton, and at least two jets, using amore » $$ \\sqrt{s}=13 $$ TeV pp collision data sample corresponding to an integrated luminosity of 12.9 fb$$^{-1}$$ collected with the CMS detector at the LHC in 2016. The number of observed events is found to be in agreement with the standard model prediction. A limit is set at 95% confidence level on the product of the leptoquark pair production cross section and β$$^{2}$$, where β is the branching fraction of leptoquark decay to a τ lepton and a bottom quark. Assuming β = 1, third-generation leptoquarks with masses below 850 GeV are excluded at 95% confidence level. An additional search based on the same event topology involves heavy right-handed neutrinos, N$$_{R}$$, and right-handed W bosons, W$$_{R}$$, arising in a left-right symmetric extension of the standard model. In this search, W$$_{R}$$ bosons are assumed to decay to a tau lepton and N$$_{R}$$ followed by the decay of the N$$_{R}$$ to a tau lepton and an off-shell W$$_{R}$$ boson. Assuming the mass of the right-handed neutrino to be half of the mass of the right-handed W boson, W$$_{R}$$ boson masses below 2.9 TeV are excluded at 95% confidence level. Lastly, these results improve on the limits from previous searches for third-generation leptoquarks and heavy right-handed neutrinos with τ leptons in the final state.« less

Search for third-generation scalar leptoquarks and heavy right-handed neutrinos in final states with two tau leptons and two jets in proton-proton collisions at $$ \\sqrt{s}=13 $$ TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.

A search is performed for third-generation scalar leptoquarks and heavy right-handed neutrinos in events containing one electron or muon, one hadronically decaying τ lepton, and at least two jets, using amore » $$ \\sqrt{s}=13 $$ TeV pp collision data sample corresponding to an integrated luminosity of 12.9 fb$$^{-1}$$ collected with the CMS detector at the LHC in 2016. The number of observed events is found to be in agreement with the standard model prediction. A limit is set at 95% confidence level on the product of the leptoquark pair production cross section and β$$^{2}$$, where β is the branching fraction of leptoquark decay to a τ lepton and a bottom quark. Assuming β = 1, third-generation leptoquarks with masses below 850 GeV are excluded at 95% confidence level. An additional search based on the same event topology involves heavy right-handed neutrinos, N$$_{R}$$, and right-handed W bosons, W$$_{R}$$, arising in a left-right symmetric extension of the standard model. In this search, W$$_{R}$$ bosons are assumed to decay to a tau lepton and N$$_{R}$$ followed by the decay of the N$$_{R}$$ to a tau lepton and an off-shell W$$_{R}$$ boson. Assuming the mass of the right-handed neutrino to be half of the mass of the right-handed W boson, W$$_{R}$$ boson masses below 2.9 TeV are excluded at 95% confidence level. Lastly, these results improve on the limits from previous searches for third-generation leptoquarks and heavy right-handed neutrinos with τ leptons in the final state.« less

Sterile neutrinos and flavor ratios in IceCube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brdar, Vedran; Kopp, Joachim; Wang, Xiao-Ping, E-mail: vbrdar@uni-mainz.de, E-mail: jkopp@uni-mainz.de, E-mail: xiaowang@uni-mainz.de

2017-01-01

The flavor composition of astrophysical neutrinos observed in neutrino telescopes is a powerful discriminator between different astrophysical neutrino production mechanisms and can also teach us about the particle physics properties of neutrinos. In this paper, we investigate how the possible existence of light sterile neutrinos can affect these flavor ratios. We consider two scenarios: (i) neutrino production in conventional astrophysical sources, followed by partial oscillation into sterile states; (ii) neutrinos from dark matter decay with a primary flavor composition enhanced in tau neutrinos or sterile neutrinos. Throughout the paper, we constrain the sterile neutrino mixing parameters from a full globalmore » fit to short and long baseline data. We present our results in the form of flavor triangles and, for scenario (ii), as exclusion limits on the dark matter mass and lifetime, derived from a fit to IceCube high energy starting events and through-going muons. We argue that identifying a possible flux of neutrinos from dark matter decay may require analyzing the flavor composition as a function of neutrino energy.« less

Lepton Flavorful Fifth Force and Depth-Dependent Neutrino Matter Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wise, Mark B.; Zhang, Yue

We consider a fifth force to be an interaction that couples to matter with a strength that grows with the number of atoms. In addition to competing with the strength of gravity a fifth force can give rise to violations of the equivalence principle. Current long range constraints on the strength and range of fifth forces are very impressive. Amongst possible fifth forces are those that couple to lepton flavorful chargesmore » $$L_e-L_{\\mu}$$ or $$L_e-L_{\\tau}$$. They have the property that their range and strength are also constrained by neutrino interactions with matter. In this brief note we review the existing constraints on the allowed parameter space in gauged $$U(1)_{L_e-L_{\\mu}, L_{\\tau}}$$. We find two regions where neutrino oscillation experiments are at the frontier of probing such a new force. In particular, there is an allowed range of parameter space where neutrino matter interactions relevant for long baseline oscillation experiments depend on the depth of the neutrino beam below the surface of the earth.« less

A Search for Ultra-High Energy Neutrinos in Highly Inclined Events at the Pierre Auger Observatory

DOE PAGES

Abreu, P

2011-12-30

The Surface Detector of the Pierre Auger Observatory is sensitive to neutrinos of all flavors above 0.1 EeV. These interact through charged and neutral currents in the atmosphere giving rise to extensive air showers. When interacting deeply in the atmosphere at nearly horizontal incidence, neutrinos can be distinguished from regular hadronic cosmic rays by the broad time structure of their shower signals in the water-Cherenkov detectors. In this paper we present for the first time an analysis based on down-going neutrinos. We describe the search procedure, the possible sources of background, the method to compute the exposure and the associatedmore » systematic uncertainties. No candidate neutrinos have been found in data collected from 1 January 2004 to 31 May 2010. Assuming an E -2 differential energy spectrum the limit on the single-flavor neutrino is E 2dN/dE < 1.74 x 10 -7 GeV cm -2s -1sr -1 at 90% C.L. in the energy range 1 x 10 17eV < E < 1 x 10 20 eV.« less

Search for Point Sources of High Energy Neutrinos with Final Data from AMANDA-II

DOE Office of Scientific and Technical Information (OSTI.GOV)

IceCube Collaboration; Klein, Spencer

2009-03-06

We present a search for point sources of high energy neutrinos using 3.8 years of data recorded by AMANDA-II during 2000-2006. After reconstructing muon tracks and applying selection criteria designed to optimally retain neutrino-induced events originating in the Northern Sky, we arrive at a sample of 6595 candidate events, predominantly from atmospheric neutrinos with primary energy 100 GeV to 8 TeV. Our search of this sample reveals no indications of a neutrino point source. We place the most stringent limits to date on E{sup -2} neutrino fluxes from points in the Northern Sky, with an average upper limit of E{supmore » 2}{Phi}{sub {nu}{sub {mu}}+{nu}{sub {tau}}} {le} 5.2 x 10{sup -11} TeV cm{sup -2} s{sup -1} on the sum of {nu}{sub {mu}} and {nu}{sub {tau}} fluxes, assumed equal, over the energy range from 1.9 TeV to 2.5 PeV.« less

Search for point sources of high energy neutrinos with final data from AMANDA-II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abbasi, R.; Andeen, K.; Baker, M.

2009-03-15

We present a search for point sources of high energy neutrinos using 3.8 yr of data recorded by AMANDA-II during 2000-2006. After reconstructing muon tracks and applying selection criteria designed to optimally retain neutrino-induced events originating in the northern sky, we arrive at a sample of 6595 candidate events, predominantly from atmospheric neutrinos with primary energy 100 GeV to 8 TeV. Our search of this sample reveals no indications of a neutrino point source. We place the most stringent limits to date on E{sup -2} neutrino fluxes from points in the northern sky, with an average upper limit of E{supmore » 2}{phi}{sub {nu}{sub {mu}}}{sub +{nu}{sub {tau}}}{<=}5.2x10{sup -11} TeV cm{sup -2} s{sup -1} on the sum of {nu}{sub {mu}} and {nu}{sub {tau}} fluxes, assumed equal, over the energy range from 1.9 TeV to 2.5 PeV.« less

The Giant Radio Array for Neutrino Detection

NASA Astrophysics Data System (ADS)

Martineau-Huynh, Olivier; Bustamante, Mauricio; Carvalho, Washington; Charrier, Didier; De Jong, Sijbrand; de Vries, Krijn D.; Fang, Ke; Feng, Zhaoyang; Finley, Chad; Gou, Quanbu; Gu, Junhua; Hu, Hongbo; Kotera, Kumiko; Le Coz, Sandra; Medina, Clementina; Murase, Kohta; Niess, Valentin; Oikonomou, Foteini; Timmermans, Charles; Wang, Zhen; Wu, Xiangping; Zhang, Yi

2017-03-01

The Giant Radio Array for Neutrino Detection (GRAND) is a planned array of 2·105 radio antennas deployed over 200 000 km2 in a mountainous site. It aims primarly at detecting high-energy neutrinos via the observation of extensive air showers induced by the decay in the atmosphere of taus produced by the interaction of cosmic neutrinos under the Earth surface. GRAND aims at reaching a neutrino sensitivity of 5 · 10-11 E-2 GeV-1 cm-2 s-1 sr-1 above 3 · 1016 eV. This ensures the detection of cosmogenic neutrinos in the most pessimistic source models, and 50 events per year are expected for the standard models. The instrument will also detect UHECRs and possibly FRBs. Here we show how our preliminary design should enable us to reach our sensitivity goals, and discuss the steps to be taken to achieve GRAND, while the compelling science case for GRAND is discussed in more details in [1].

The Giant Radio Array for Neutrino Detection

NASA Astrophysics Data System (ADS)

Kotera, K.; GRAND Collaboration

2017-12-01

The Giant Radio Array for Neutrino Detection (GRAND) project aims at detecting ultrahigh-energy neutrinos and cosmic rays with a ˜10^5 radio antenna array over 200'000 km^2 in mountainous regions in China, in order to solve the mystery of the origin of these two linked particles. Its strategy is to detect extensive air showers of the highest energies, above 10^{17} eV, that are triggered by the interaction of high-energy particles in the atmosphere or underground. In its first stages, GRAND will be competitive to detect the first cosmogenic neutrinos for favorable source scenarios. Ultimately, GRAND aims at reaching a sensitivity and angular resolution that should launch neutrino astronomy, and that will ensure the detection of these neutrinos, even in the most pessimistic cases. We present preliminary results of our simulations, plans for the ongoing, staged approach to the construction of GRAND, and the rich research program made possible by the design of GRAND.

Studies of Cosmic Ray Composition and Air Shower Structure with the Pierre Auger Observatory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abraham, : J.; Abreu, P.; Aglietta, M.

2009-06-01

These are presentations to be presented at the 31st International Cosmic Ray Conference, in Lodz, Poland during July 2009. It consists of the following presentations: (1) Measurement of the average depth of shower maximum and its fluctuations with the Pierre Auger Observatory; (2) Study of the nuclear mass composition of UHECR with the surface detectors of the Pierre Auger Observatory; (3) Comparison of data from the Pierre Auger Observatory with predictions from air shower simulations: testing models of hadronic interactions; (4) A Monte Carlo exploration of methods to determine the UHECR composition with the Pierre Auger Observatory; (5) The delaymore » of the start-time measured with the Pierre Auger Observatory for inclined showers and a comparison of its variance with models; (6) UHE neutrino signatures in the surface detector of the Pierre Auger Observatory; and (7) The electromagnetic component of inclined air showers at the Pierre Auger Observatory.« less

Heavy Right-Handed Neutrino Dark Matter and PeV Neutrinos at IceCube

NASA Technical Reports Server (NTRS)

Bhupal Dev, P. S.; Kazanas, D.; Mohapatra, R. N.; Teplitz, V. L.; Zhang, Yongchao

2016-01-01

We discuss a simple non-supersymmetric model based on the electroweak gauge group SU(2) (sub L) times SU(2) prime times U(1) (Sub B-L) where the lightest of the right-handed neutrinos, which are part of the leptonic doublet of SU(2) prime, play the role of a long-lived unstable dark matter with mass in the multi-Peta-electronvolt range. We use a resonant s-channel annihilation to obtain the correct thermal relic density and relax the unitarity bound on dark matter mass. In this model, there exists a 3-body dark matter decay mode producing tau leptons and neutrinos, which could be the source for the Peta-electronvolt cascade events observed in the IceCube experiment. The model can be tested with more precise flavor information of the highest-energy neutrino events in future data.

Evidence for Neutral-Current Diffractive π 0 Production from Hydrogen in Neutrino Interactions on Hydrocarbon

DOE PAGES

Wolcott, J.; Aliaga, L.; Altinok, O.; ...

2016-09-01

Here, the MINERvA experiment observes an excess of events containing electromagnetic showers relative to the expectation from Monte Carlo simulations in neutral-current neutrino interactions with mean beam energy of 4.5 GeV on a hydrocarbon target. The excess is characterized and found to be consistent with neutral-current π 0 production with a broad energy distribution peaking at 7 GeV and a total cross section of 0.26more » $$\\pm$$ 0.02 (stat) $$\\pm$$ 0.08 (sys) x $$10^{-39} cm^{2}$$. The angular distribution, electromagnetic shower energy, and spatial distribution of the energy depositions of the excess are consistent with expectations from neutrino neutral-current diffractive neutral pion production from hydrogen in the hydrocarbon target. These data comprise the first direct experimental observation and constraint for a reaction that poses an important background process in neutrino oscillation experiments searching for $$\

Search for W' decaying to tau lepton and neutrino in proton-proton collisions at $$\\sqrt{s}$$ = 8 TeV

DOE PAGES

Khachatryan, Vardan

2016-02-03

We found that the first search for a heavy charged vector boson in the final state with a tau lepton and a neutrino is reported, using 19.7 fb -1 of LHC data at √s = 8 TeV. A signal would appear as an excess of events in kinematic regions where the standard model background is low. No excess is observed. Limits are set on a model in which the W' decays preferentially to fermions of the third generation. Our results substantially extend previous constraints on this model. Masses below 2.0 to 2.7 TeV are excluded, depending on the model parameters.more » In addition, the existence of a W' boson with universal fermion couplings is excluded at 95% confidence level, for W' masses below 2.7 TeV.« less

Petit-exposure at neutrino beamline (PEANUT)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Niwa, K.; /Nagoya U.

2005-08-01

The advantages of using nuclear emulsion as a particle detector are well known. The high resolution of emulsion has made it a medium of choice for a number of applications where the required spatial and angular resolution are paramount and its limitations due to the lack of timing information are less important. Emulsions are commonly used as cosmic ray detectors and have found applications in high energy experiments for detecting short lived particles such as charm, beauty and tau. The addition of electronic detectors to emulsion experiments solved the problem of the lack of timing information in the emulsion, butmore » it was the development of automatic scanning machines that revolutionized the use of these hybrid detectors, making them capable of performing even in high rate environments. Most recently, The DONuT experiment (FNAL-E872), used a hybrid emulsion spectrometer to make the first direct observation of tau neutrino interactions [1]. The CNGS facility is being constructed to deliver a {nu}{sub {mu}} beam from the CERN SPS to the Gran Sasso Laboratory. Since it is believed that {nu}{sub {mu}} {leftrightarrow} {nu}{sub {tau}} oscillations explain the observed atmospheric {nu}{sub {mu}} deficit, the CNGS beam, coupled with a detector capable of observing {tau} appearance is an important experiment in the context of the world wide effort to determine the neutrino mass mixing matrix. The OPERA detector has been optimized to detect a significant sample of {nu}{sub {tau}} interactions by the subsequent observation of {tau} production and decay [2]. The OPERA target is a massive emulsion detector made in a sandwich structure of lead plates and layers of nuclear emulsion. For historical reasons this arrangement has been called an Emulsion Cloud Chamber or ECC. The ECC concept, which has many advantages over the use of bulk emulsion, has been used in the DONuT experiment. The ECC detector is capable of measuring all of the tracks, not due to nuclear fragments

Heavy right-handed neutrino dark matter and PeV neutrinos at IceCube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dev, P.S. Bhupal; Kazanas, D.; Mohapatra, R.N.

2016-08-17

We discuss a simple non-supersymmetric model based on the electroweak gauge group SU(2){sub L}×SU(2){sup ′}×U(1){sub B−L} where the lightest of the right-handed neutrinos, which are part of the leptonic doublet of SU(2){sup ′}, play the role of a long-lived unstable dark matter with mass in the multi-PeV range. We use a resonant s-channel annihilation to obtain the correct thermal relic density and relax the unitarity bound on dark matter mass. In this model, there exists a 3-body dark matter decay mode producing tau leptons and neutrinos, which could be the source for the PeV cascade events observed in the IceCubemore » experiment. The model can be tested with more precise flavor information of the highest-energy neutrino events in future data.« less

Nuclear Emulsion Analysis Methods of Locating Neutrino Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erickson, Carolyn Lee

2006-12-01

The Fermilab experiment 872 (DONUT) was the first to directly observe tau neutrinos in the charged current interactionV more » $$\\tau$$+N →$$\\tau$$ +X. The observation was made using a hybrid emulsion-spectrometer detector to identify the signature kink or trident decay of the tau particle. Although nuclear emulsion has the benefit of sub-micron resolution, its use incorporates difficulties such as significant distortions and a high density of data resulting from its continuously active state. Finding events and achieving sub-micron resolution in emulsion requires a multi-pronged strategy of tracking and vertex location to deal with these inherent difficulties. By applying the methods developed in this thesis, event location efficiency can be improved from a value of 58% to 87%.« less

The Potential of Spaced-based High-Energy Neutrino Measurements via the Airshower Cherenkov Signal

NASA Technical Reports Server (NTRS)

Krizmanic, John F.; Mitchell, John W.

2011-01-01

Future space-based experiments, such as (Orbiting Wide-angle Light Collectors (OWL) and JEM-EUSO, view large atmospheric and terrestrial neutrino targets. With energy thresholds slightly above 10(exp 19) eV for observing airshowers via air fluorescence, the potential for observing the cosmogenic neutrino flux associated with the GZK effect is limited. However, the forward Cherenkov signal associated with the airshower can be observed at much lower energies. A simulation was developed to determine the Cherenkov signal strength and spatial extent at low-Earth orbit for upward-moving airshowers. A model of tau neutrino interactions in the Earth was employed to determine the event rate of interactions that yielded a tau lepton which would induce an upward-moving airshower observable by a space-based instrument. The effect of neutrino attenuation by the Earth forces the viewing of the Earth's limb to observe the vT-induced Cherenkov airshower signal at above the OWL Cherenkov energy threshold of approximately 10(exp 16.5) eV for limb-viewed events. Furthermore, the neutrino attenuation limits the effective terrestrial neutrino target area to approximately 3 x 10(exp 5) square km at 10(exp 17) eV, for an orbit of 1000 km and an instrumental full Field-of-View of 45 deg. This translates into an observable cosmogenic neutrino event rate of approx. l/year based upon two different models of the cosmogenic neutrino flux, assuming neutrino oscillations and a 10% duty cycle for observation.

Astrophysical neutrinos flavored with beyond the Standard Model physics

NASA Astrophysics Data System (ADS)

Rasmussen, Rasmus W.; Lechner, Lukas; Ackermann, Markus; Kowalski, Marek; Winter, Walter

2017-10-01

We systematically study the allowed parameter space for the flavor composition of astrophysical neutrinos measured at Earth, including beyond the Standard Model theories at production, during propagation, and at detection. One motivation is to illustrate the discrimination power of the next-generation neutrino telescopes such as IceCube-Gen2. We identify several examples that lead to potential deviations from the standard neutrino mixing expectation such as significant sterile neutrino production at the source, effective operators modifying the neutrino propagation at high energies, dark matter interactions in neutrino propagation, or nonstandard interactions in Earth matter. IceCube-Gen2 can exclude about 90% of the allowed parameter space in these cases, and hence will allow us to efficiently test and discriminate between models. More detailed information can be obtained from additional observables such as the energy dependence of the effect, fraction of electron antineutrinos at the Glashow resonance, or number of tau neutrino events.

A new study of shower age distribution in near vertical showers by EAS air shower array

NASA Technical Reports Server (NTRS)

Chaudhuri, N.; Basak, D. K.; Goswami, G. C.; Ghosh, B.

1984-01-01

The air shower array has been developed since it started operation in 1931. The array covering an area of 900 sq m now incorporates 21 particle density sampling detectors around two muon magnetic spectrographs. The air showers are detected in the size range 10 to the 4th power to 10 to the 6th power particles. A total of 11000 showers has so far been detected. Average values of shower age have been obtained in various shower size ranges to study the dependence of shower age on shower size. The core distance dependence of shower age parameter has also been analyzed for presentation.

Search for W‧ decaying to tau lepton and neutrino in proton-proton collisions at √{ s} = 8 TeV

NASA Astrophysics Data System (ADS)

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Knünz, V.; König, A.; Krammer, M.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Strauss, J.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; Cornelis, T.; de Wolf, E. A.; Janssen, X.; Knutsson, A.; Lauwers, J.; Luyckx, S.; Ochesanu, S.; Rougny, R.; van de Klundert, M.; van Haevermaet, H.; van Mechelen, P.; van Remortel, N.; van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; Daci, N.; de Bruyn, I.; Deroover, K.; Heracleous, N.; Keaveney, J.; Lowette, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; van Doninck, W.; van Mulders, P.; van Onsem, G. P.; van Parijs, I.; Barria, P.; Caillol, C.; Clerbaux, B.; de Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Gay, A. P. R.; Grebenyuk, A.; Lenzi, T.; Léonard, A.; Maerschalk, T.; Marinov, A.; Perniè, L.; Randle-Conde, A.; Reis, T.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Yonamine, R.; Zenoni, F.; Zhang, F.; Beernaert, K.; Benucci, L.; Cimmino, A.; Crucy, S.; Dobur, D.; Fagot, A.; Garcia, G.; Gul, M.; McCartin, J.; Ocampo Rios, A. A.; Poyraz, D.; Ryckbosch, D.; Salva, S.; Sigamani, M.; Strobbe, N.; Tytgat, M.; van Driessche, W.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Beluffi, C.; Bondu, O.; Brochet, S.; Bruno, G.; Castello, R.; Caudron, A.; Ceard, L.; da Silveira, G. G.; Delaere, C.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Jafari, A.; Jez, P.; Komm, M.; Lemaitre, V.; Mertens, A.; Nuttens, C.; Perrini, L.; Pin, A.; Piotrzkowski, K.; Popov, A.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Beliy, N.; Hammad, G. H.; Aldá Júnior, W. L.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Hensel, C.; Mora Herrera, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; da Costa, E. M.; de Jesus Damiao, D.; de Oliveira Martins, C.; Fonseca de Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Prado da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; de Souza Santos, A.; Dogra, S.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Genchev, V.; Hadjiiska, R.; Iaydjiev, P.; Piperov, S.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Cheng, T.; Du, R.; Jiang, C. H.; Plestina, R.; Romeo, F.; Shaheen, S. M.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Asawatangtrakuldee, C.; Ban, Y.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Zou, W.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; Gomez Moreno, B.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Polic, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Kadija, K.; Luetic, J.; Micanovic, S.; Sudic, L.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Bodlak, M.; Finger, M.; Finger, M.; Assran, Y.; Elgammal, S.; Mahmoud, M. A.; Calpas, B.; Kadastik, M.; Murumaa, M.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Locci, E.; Machet, M.; Malcles, J.; Rander, J.; Rosowsky, A.; Titov, M.; Zghiche, A.; Antropov, I.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Chapon, E.; Charlot, C.; Dahms, T.; Davignon, O.; Filipovic, N.; Florent, A.; Granier de Cassagnac, R.; Lisniak, S.; Mastrolorenzo, L.; Miné, P.; Naranjo, I. N.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Regnard, S.; Salerno, R.; Sauvan, J. B.; Sirois, Y.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Agram, J.-L.; Andrea, J.; Aubin, A.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Goetzmann, C.; Le Bihan, A.-C.; Merlin, J. A.; Skovpen, K.; van Hove, P.; Gadrat, S.; Beauceron, S.; Bernet, C.; Boudoul, G.; Bouvier, E.; Carrillo Montoya, C. A.; Chasserat, J.; Chierici, R.; Contardo, D.; Courbon, B.; Depasse, P.; El Mamouni, H.; Fan, J.; Fay, J.; Gascon, S.; Gouzevitch, M.; Ille, B.; Lagarde, F.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Ruiz Alvarez, J. D.; Sabes, D.; Sgandurra, L.; Sordini, V.; Vander Donckt, M.; Verdier, P.; Viret, S.; Xiao, H.; Toriashvili, T.; Tsamalaidze, Z.; Autermann, C.; Beranek, S.; Edelhoff, M.; Feld, L.; Heister, A.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Ostapchuk, A.; Preuten, M.; Raupach, F.; Schael, S.; Schulte, J. F.; Verlage, T.; Weber, H.; Wittmer, B.; Zhukov, V.; Ata, M.; Brodski, M.; Dietz-Laursonn, E.; Duchardt, D.; Edelhäuser, L.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Klingebiel, D.; Knochel, A.; Knutzen, S.; Kreuzer, P.; Merschmeyer, M.; Meyer, A.; Millet, P.; Olschewski, M.; Padeken, K.; Papacz, P.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Sonnenschein, L.; Teyssier, D.; Thüer, S.; Cherepanov, V.; Erdogan, Y.; Flügge, G.; Geenen, H.; Geisler, M.; Hoehle, F.; Kargoll, B.; Kress, T.; Kuessel, Y.; Künsken, A.; Lingemann, J.; Nehrkorn, A.; Nowack, A.; Nugent, I. M.; Pistone, C.; Pooth, O.; Stahl, A.; Aldaya Martin, M.; Asin, I.; Bartosik, N.; Behnke, O.; Behrens, U.; Bell, A. J.; Borras, K.; Burgmeier, A.; Cakir, A.; Calligaris, L.; Campbell, A.; Choudhury, S.; Costanza, F.; Diez Pardos, C.; Dolinska, G.; Dooling, S.; Dorland, T.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Flucke, G.; Gallo, E.; Garay Garcia, J.; Geiser, A.; Gizhko, A.; Gunnellini, P.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Karacheban, O.; Kasemann, M.; Katsas, P.; Kieseler, J.; Kleinwort, C.; Korol, I.; Lange, W.; Leonard, J.; Lipka, K.; Lobanov, A.; Lohmann, W.; Mankel, R.; Marfin, I.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Naumann-Emme, S.; Nayak, A.; Ntomari, E.; Perrey, H.; Pitzl, D.; Placakyte, R.; Raspereza, A.; Roland, B.; Sahin, M. Ö.; Saxena, P.; Schoerner-Sadenius, T.; Schröder, M.; Seitz, C.; Spannagel, S.; Trippkewitz, K. D.; Walsh, R.; Wissing, C.; Blobel, V.; Centis Vignali, M.; Draeger, A. R.; Erfle, J.; Garutti, E.; Goebel, K.; Gonzalez, D.; Görner, M.; Haller, J.; Hoffmann, M.; Höing, R. S.; Junkes, A.; Klanner, R.; Kogler, R.; Lapsien, T.; Lenz, T.; Marchesini, I.; Marconi, D.; Nowatschin, D.; Ott, J.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Pietsch, N.; Poehlsen, J.; Rathjens, D.; Sander, C.; Schettler, H.; Schleper, P.; Schlieckau, E.; Schmidt, A.; Schwandt, J.; Seidel, M.; Sola, V.; Stadie, H.; Steinbrück, G.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Akbiyik, M.; Barth, C.; Baus, C.; Berger, J.; Böser, C.; Butz, E.; Chwalek, T.; Colombo, F.; de Boer, W.; Descroix, A.; Dierlamm, A.; Fink, S.; Frensch, F.; Giffels, M.; Gilbert, A.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Kassel, F.; Katkov, I.; Kornmayer, A.; Lobelle Pardo, P.; Maier, B.; Mildner, H.; Mozer, M. U.; Müller, T.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Röcker, S.; Roscher, F.; Simonis, H. J.; Stober, F. M.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weber, M.; Weiler, T.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Psallidas, A.; Topsis-Giotis, I.; Agapitos, A.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Tziaferi, E.; Evangelou, I.; Flouris, G.; Foudas, C.; Kokkas, P.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Strologas, J.; Bencze, G.; Hajdu, C.; Hazi, A.; Hidas, P.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Molnar, J.; Szillasi, Z.; Bartók, M.; Makovec, A.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Mal, P.; Mandal, K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chawla, R.; Gupta, R.; Bhawandeep, U.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Mehta, A.; Mittal, M.; Singh, J. B.; Walia, G.; Kumar, Ashok; Kumar, Arun; Bhardwaj, A.; Choudhary, B. C.; Garg, R. B.; Kumar, A.; Malhotra, S.; Naimuddin, M.; Nishu, N.; Ranjan, K.; Sharma, R.; Sharma, V.; Banerjee, S.; Bhattacharya, S.; Chatterjee, K.; Dey, S.; Dutta, S.; Jain, Sa.; Majumdar, N.; Modak, A.; Mondal, K.; Mukherjee, S.; Mukhopadhyay, S.; Roy, A.; Roy, D.; Roy Chowdhury, S.; Sarkar, S.; Sharan, M.; Abdulsalam, A.; Chudasama, R.; Dutta, D.; Jha, V.; Kumar, V.; Mohanty, A. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Banerjee, S.; Bhowmik, S.; Chatterjee, R. M.; Dewanjee, R. K.; Dugad, S.; Ganguly, S.; Ghosh, S.; Guchait, M.; Gurtu, A.; Kole, G.; Kumar, S.; Mahakud, B.; Maity, M.; Majumder, G.; Mazumdar, K.; Mitra, S.; Mohanty, G. B.; Parida, B.; Sarkar, T.; Sudhakar, K.; Sur, N.; Sutar, B.; Wickramage, N.; Chauhan, S.; Dube, S.; Sharma, S.; Bakhshiansohi, H.; Behnamian, H.; Etesami, S. M.; Fahim, A.; Goldouzian, R.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Chhibra, S. S.; Colaleo, A.; Creanza, D.; Cristella, L.; de Filippis, N.; de Palma, M.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Benvenuti, A. C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Travaglini, R.; Cappello, G.; Chiorboli, M.; Costa, S.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Gonzi, S.; Gori, V.; Lenzi, P.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Tropiano, A.; Viliani, L.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Calvelli, V.; Ferro, F.; Lo Vetere, M.; Monge, M. R.; Robutti, E.; Tosi, S.; Brianza, L.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Gerosa, R.; Ghezzi, A.; Govoni, P.; Malvezzi, S.; Manzoni, R. A.; Marzocchi, B.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Ragazzi, S.; Redaelli, N.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; di Guida, S.; Esposito, M.; Fabozzi, F.; Iorio, A. O. M.; Lanza, G.; Lista, L.; Meola, S.; Merola, M.; Paolucci, P.; Sciacca, C.; Thyssen, F.; Azzi, P.; Bacchetta, N.; Benato, L.; Bisello, D.; Boletti, A.; Branca, A.; Carlin, R.; Checchia, P.; Dall'Osso, M.; Dorigo, T.; Gasparini, F.; Gasparini, U.; Gozzelino, A.; Kanishchev, K.; Lacaprara, S.; Margoni, M.; Meneguzzo, A. T.; Montecassiano, F.; Passaseo, M.; Pazzini, J.; Pozzobon, N.; Ronchese, P.; Simonetto, F.; Torassa, E.; Tosi, M.; Zanetti, M.; Zotto, P.; Zucchetta, A.; Zumerle, G.; Braghieri, A.; Magnani, A.; Montagna, P.; Ratti, S. P.; Re, V.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Alunni Solestizi, L.; Biasini, M.; Bilei, G. M.; Ciangottini, D.; Fanò, L.; Lariccia, P.; Mantovani, G.; Menichelli, M.; Saha, A.; Santocchia, A.; Spiezia, A.; Androsov, K.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Broccolo, G.; Castaldi, R.; Ciocci, M. A.; Dell'Orso, R.; Donato, S.; Fedi, G.; Foà, L.; Giassi, A.; Grippo, M. T.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Savoy-Navarro, A.; Serban, A. T.; Spagnolo, P.; Squillacioti, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; D'Imperio, G.; Del Re, D.; Diemoz, M.; Gelli, S.; Jorda, C.; Longo, E.; Margaroli, F.; Meridiani, P.; Micheli, F.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Traczyk, P.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bellan, R.; Biino, C.; Cartiglia, N.; Costa, M.; Covarelli, R.; de Remigis, P.; Degano, A.; Demaria, N.; Finco, L.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Musich, M.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. L.; Ravera, F.; Romero, A.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Tamponi, U.; Belforte, S.; Candelise, V.; Casarsa, M.; Cossutti, F.; Della Ricca, G.; Gobbo, B.; La Licata, C.; Marone, M.; Schizzi, A.; Umer, T.; Zanetti, A.; Chang, S.; Kropivnitskaya, A.; Nam, S. K.; Kim, D. H.; Kim, G. N.; Kim, M. S.; Kong, D. J.; Lee, S.; Oh, Y. D.; Sakharov, A.; Son, D. C.; Brochero Cifuentes, J. A.; Kim, H.; Kim, T. J.; Ryu, M. S.; Song, S.; Choi, S.; Go, Y.; Gyun, D.; Hong, B.; Jo, M.; Kim, H.; Kim, Y.; Lee, B.; Lee, K.; Lee, K. S.; Lee, S.; Park, S. K.; Roh, Y.; Yoo, H. D.; Choi, M.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Ryu, G.; Choi, Y.; Choi, Y. K.; Goh, J.; Kim, D.; Kwon, E.; Lee, J.; Yu, I.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Komaragiri, J. R.; Md Ali, M. A. B.; Mohamad Idris, F.; Wan Abdullah, W. A. T.; Yusli, M. N.; Casimiro Linares, E.; Castilla-Valdez, H.; de La Cruz-Burelo, E.; Heredia-de La Cruz, I.; Hernandez-Almada, A.; Lopez-Fernandez, R.; Sanchez-Hernandez, A.; Carrillo Moreno, S.; Vazquez Valencia, F.; Carpinteyro, S.; Pedraza, I.; Salazar Ibarguen, H. A.; Morelos Pineda, A.; Krofcheck, D.; Butler, P. H.; Reucroft, S.; Ahmad, A.; Ahmad, M.; Hassan, Q.; Hoorani, H. R.; Khan, W. A.; Khurshid, T.; Shoaib, M.; Bialkowska, H.; Bluj, M.; Boimska, B.; Frueboes, T.; Górski, M.; Kazana, M.; Nawrocki, K.; Romanowska-Rybinska, K.; Szleper, M.; Zalewski, P.; Brona, G.; Bunkowski, K.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Misiura, M.; Olszewski, M.; Walczak, M.; Bargassa, P.; Beirão da Cruz E Silva, C.; di Francesco, A.; Faccioli, P.; Ferreira Parracho, P. G.; Gallinaro, M.; Leonardo, N.; Lloret Iglesias, L.; Nguyen, F.; Rodrigues Antunes, J.; Seixas, J.; Toldaiev, O.; Vadruccio, D.; Varela, J.; Vischia, P.; Afanasiev, S.; Bunin, P.; Gavrilenko, M.; Golutvin, I.; Gorbunov, I.; Kamenev, A.; Karjavin, V.; Konoplyanikov, V.; Lanev, A.; Malakhov, A.; Matveev, V.; Moisenz, P.; Palichik, V.; Perelygin, V.; Shmatov, S.; Shulha, S.; Skatchkov, N.; Smirnov, V.; Zarubin, A.; Golovtsov, V.; Ivanov, Y.; Kim, V.; Kuznetsova, E.; Levchenko, P.; Murzin, V.; Oreshkin, V.; Smirnov, I.; Sulimov, V.; Uvarov, L.; Vavilov, S.; Vorobyev, A.; Andreev, Yu.; Dermenev, A.; Gninenko, S.; Golubev, N.; Karneyeu, A.; Kirsanov, M.; Krasnikov, N.; Pashenkov, A.; Tlisov, D.; Toropin, A.; Epshteyn, V.; Gavrilov, V.; Lychkovskaya, N.; Popov, V.; Pozdnyakov, I.; Safronov, G.; Spiridonov, A.; Vlasov, E.; Zhokin, A.; Bylinkin, A.; Andreev, V.; Azarkin, M.; Dremin, I.; Kirakosyan, M.; Leonidov, A.; Mesyats, G.; Rusakov, S. V.; Vinogradov, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Bunichev, V.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Myagkov, I.; Obraztsov, S.; Perfilov, M.; Savrin, V.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Tourtchanovitch, L.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Ekmedzic, M.; Milosevic, J.; Rekovic, V.; Alcaraz Maestre, J.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Colino, N.; de La Cruz, B.; Delgado Peris, A.; Domínguez Vázquez, D.; Escalante Del Valle, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Navarro de Martino, E.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Soares, M. S.; Albajar, C.; de Trocóniz, J. F.; Missiroli, M.; Moran, D.; Brun, H.; Cuevas, J.; Fernandez Menendez, J.; Folgueras, S.; Gonzalez Caballero, I.; Palencia Cortezon, E.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Castiñeiras de Saa, J. R.; de Castro Manzano, P.; Duarte Campderros, J.; Fernandez, M.; Gomez, G.; Graziano, A.; Lopez Virto, A.; Marco, J.; Marco, R.; Martinez Rivero, C.; Matorras, F.; Munoz Sanchez, F. J.; Piedra Gomez, J.; Rodrigo, T.; Rodríguez-Marrero, A. Y.; Ruiz-Jimeno, A.; Scodellaro, L.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Bachtis, M.; Baillon, P.; Ball, A. H.; Barney, D.; Benaglia, A.; Bendavid, J.; Benhabib, L.; Benitez, J. F.; Berruti, G. M.; Bloch, P.; Bocci, A.; Bonato, A.; Botta, C.; Breuker, H.; Camporesi, T.; Cerminara, G.; Colafranceschi, S.; D'Alfonso, M.; D'Enterria, D.; Dabrowski, A.; Daponte, V.; David, A.; de Gruttola, M.; de Guio, F.; de Roeck, A.; de Visscher, S.; di Marco, E.; Dobson, M.; Dordevic, M.; Du Pree, T.; Dupont, N.; Elliott-Peisert, A.; Franzoni, G.; Funk, W.; Gigi, D.; Gill, K.; Giordano, D.; Girone, M.; Glege, F.; Guida, R.; Gundacker, S.; Guthoff, M.; Hammer, J.; Hansen, M.; Harris, P.; Hegeman, J.; Innocente, V.; Janot, P.; Kirschenmann, H.; Kortelainen, M. J.; Kousouris, K.; Krajczar, K.; Lecoq, P.; Lourenço, C.; Lucchini, M. T.; Magini, N.; Malgeri, L.; Mannelli, M.; Martelli, A.; Masetti, L.; Meijers, F.; Mersi, S.; Meschi, E.; Moortgat, F.; Morovic, S.; Mulders, M.; Nemallapudi, M. V.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Piparo, D.; Racz, A.; Rolandi, G.; Rovere, M.; Ruan, M.; Sakulin, H.; Schäfer, C.; Schwick, C.; Sharma, A.; Silva, P.; Simon, M.; Sphicas, P.; Spiga, D.; Steggemann, J.; Stieger, B.; Stoye, M.; Takahashi, Y.; Treille, D.; Triossi, A.; Tsirou, A.; Veres, G. I.; Wardle, N.; Wöhri, H. K.; Zagozdzinska, A.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Renker, D.; Rohe, T.; Bachmair, F.; Bäni, L.; Bianchini, L.; Buchmann, M. A.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Dünser, M.; Eller, P.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Lustermann, W.; Mangano, B.; Marini, A. C.; Marionneau, M.; Martinez Ruiz Del Arbol, P.; Masciovecchio, M.; Meister, D.; Musella, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pata, J.; Pauss, F.; Perrozzi, L.; Peruzzi, M.; Quittnat, M.; Rossini, M.; Starodumov, A.; Takahashi, M.; Tavolaro, V. R.; Theofilatos, K.; Wallny, R.; Aarrestad, T. K.; Amsler, C.; Caminada, L.; Canelli, M. F.; Chiochia, V.; de Cosa, A.; Galloni, C.; Hinzmann, A.; Hreus, T.; Kilminster, B.; Lange, C.; Ngadiuba, J.; Pinna, D.; Robmann, P.; Ronga, F. J.; Salerno, D.; Yang, Y.; Cardaci, M.; Chen, K. H.; Doan, T. H.; Ferro, C.; Jain, Sh.; Khurana, R.; Konyushikhin, M.; Kuo, C. M.; Lin, W.; Lu, Y. J.; Volpe, R.; Yu, S. S.; Bartek, R.; Chang, P.; Chang, Y. H.; Chang, Y. W.; Chao, Y.; Chen, K. F.; Chen, P. H.; Dietz, C.; Fiori, F.; Grundler, U.; Hou, W.-S.; Hsiung, Y.; Liu, Y. F.; Lu, R.-S.; Miñano Moya, M.; Petrakou, E.; Tsai, J. F.; Tzeng, Y. M.; Asavapibhop, B.; Kovitanggoon, K.; Singh, G.; Srimanobhas, N.; Suwonjandee, N.; Adiguzel, A.; Bakirci, M. N.; Dozen, C.; Dumanoglu, I.; Eskut, E.; Girgis, S.; Gokbulut, G.; Guler, Y.; Gurpinar, E.; Hos, I.; Kangal, E. E.; Onengut, G.; Ozdemir, K.; Ozturk, S.; Polatoz, A.; Sunar Cerci, D.; Vergili, M.; Zorbilmez, C.; Akin, I. V.; Bilin, B.; Bilmis, S.; Isildak, B.; Karapinar, G.; Surat, U. E.; Yalvac, M.; Zeyrek, M.; Albayrak, E. A.; Gülmez, E.; Kaya, M.; Kaya, O.; Yetkin, T.; Cankocak, K.; Sen, S.; Vardarlı, F. I.; Grynyov, B.; Levchuk, L.; Sorokin, P.; Aggleton, R.; Ball, F.; Beck, L.; Brooke, J. J.; Clement, E.; Cussans, D.; Flacher, H.; Goldstein, J.; Grimes, M.; Heath, G. P.; Heath, H. F.; Jacob, J.; Kreczko, L.; Lucas, C.; Meng, Z.; Newbold, D. M.; Paramesvaran, S.; Poll, A.; Sakuma, T.; Seif El Nasr-Storey, S.; Senkin, S.; Smith, D.; Smith, V. J.; Bell, K. W.; Belyaev, A.; Brew, C.; Brown, R. M.; Cockerill, D. J. A.; Coughlan, J. A.; Harder, K.; Harper, S.; Olaiya, E.; Petyt, D.; Shepherd-Themistocleous, C. H.; Thea, A.; Thomas, L.; Tomalin, I. R.; Williams, T.; Womersley, W. J.; Worm, S. D.; Baber, M.; Bainbridge, R.; Buchmuller, O.; Bundock, A.; Burton, D.; Casasso, S.; Citron, M.; Colling, D.; Corpe, L.; Cripps, N.; Dauncey, P.; Davies, G.; de Wit, A.; Della Negra, M.; Dunne, P.; Elwood, A.; Ferguson, W.; Fulcher, J.; Futyan, D.; Hall, G.; Iles, G.; Karapostoli, G.; Kenzie, M.; Lane, R.; Lucas, R.; Lyons, L.; Magnan, A.-M.; Malik, S.; Nash, J.; Nikitenko, A.; Pela, J.; Pesaresi, M.; Petridis, K.; Raymond, D. M.; Richards, A.; Rose, A.; Seez, C.; Tapper, A.; Uchida, K.; Vazquez Acosta, M.; Virdee, T.; Zenz, S. C.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Leggat, D.; Leslie, D.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Borzou, A.; Call, K.; Dittmann, J.; Hatakeyama, K.; Kasmi, A.; Liu, H.; Pastika, N.; Charaf, O.; Cooper, S. I.; Henderson, C.; Rumerio, P.; Avetisyan, A.; Bose, T.; Fantasia, C.; Gastler, D.; Lawson, P.; Rankin, D.; Richardson, C.; Rohlf, J.; St. John, J.; Sulak, L.; Zou, D.; Alimena, J.; Berry, E.; Bhattacharya, S.; Cutts, D.; Dhingra, N.; Ferapontov, A.; Garabedian, A.; Heintz, U.; Laird, E.; Landsberg, G.; Mao, Z.; Narain, M.; Sagir, S.; Sinthuprasith, T.; Breedon, R.; Breto, G.; Calderon de La Barca Sanchez, M.; Chauhan, S.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Gardner, M.; Ko, W.; Lander, R.; Mulhearn, M.; Pellett, D.; Pilot, J.; Ricci-Tam, F.; Shalhout, S.; Smith, J.; Squires, M.; Stolp, D.; Tripathi, M.; Wilbur, S.; Yohay, R.; Cousins, R.; Everaerts, P.; Farrell, C.; Hauser, J.; Ignatenko, M.; Saltzberg, D.; Takasugi, E.; Valuev, V.; Weber, M.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Hanson, G.; Heilman, J.; Ivova Paneva, M.; Jandir, P.; Kennedy, E.; Lacroix, F.; Long, O. R.; Luthra, A.; Malberti, M.; Olmedo Negrete, M.; Shrinivas, A.; Wei, H.; Wimpenny, S.; Branson, J. G.; Cerati, G. B.; Cittolin, S.; D'Agnolo, R. T.; Holzner, A.; Kelley, R.; Klein, D.; Letts, J.; MacNeill, I.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Vartak, A.; Wasserbaech, S.; Welke, C.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Barge, D.; Bradmiller-Feld, J.; Campagnari, C.; Dishaw, A.; Dutta, V.; Flowers, K.; Franco Sevilla, M.; Geffert, P.; George, C.; Golf, F.; Gouskos, L.; Gran, J.; Incandela, J.; Justus, C.; McColl, N.; Mullin, S. D.; Richman, J.; Stuart, D.; Suarez, I.; To, W.; West, C.; Yoo, J.; Anderson, D.; Apresyan, A.; Bornheim, A.; Bunn, J.; Chen, Y.; Duarte, J.; Mott, A.; Newman, H. B.; Pena, C.; Pierini, M.; Spiropulu, M.; Vlimant, J. R.; Xie, S.; Zhu, R. Y.; Azzolini, V.; Calamba, A.; Carlson, B.; Ferguson, T.; Iiyama, Y.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Cumalat, J. P.; Ford, W. T.; Gaz, A.; Jensen, F.; Johnson, A.; Krohn, M.; Mulholland, T.; Nauenberg, U.; Smith, J. G.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chatterjee, A.; Chaves, J.; Chu, J.; Dittmer, S.; Eggert, N.; Mirman, N.; Nicolas Kaufman, G.; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Sun, W.; Tan, S. M.; Teo, W. D.; Thom, J.; Thompson, J.; Tucker, J.; Weng, Y.; Wittich, P.; Abdullin, S.; Albrow, M.; Anderson, J.; Apollinari, G.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hanlon, J.; Hare, D.; Harris, R. M.; Hirschauer, J.; Hooberman, B.; Hu, Z.; Jindariani, S.; Johnson, M.; Joshi, U.; Jung, A. W.; Klima, B.; Kreis, B.; Kwan, S.; Lammel, S.; Linacre, J.; Lincoln, D.; Lipton, R.; Liu, T.; Lopes de Sá, R.; Lykken, J.; Maeshima, K.; Marraffino, J. M.; Martinez Outschoorn, V. I.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mishra, K.; Mrenna, S.; Nahn, S.; Newman-Holmes, C.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Weber, H. A.; Whitbeck, A.; Yang, F.; Yin, H.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Carnes, A.; Carver, M.; Curry, D.; Das, S.; di Giovanni, G. P.; Field, R. D.; Fisher, M.; Furic, I. K.; Hugon, J.; Konigsberg, J.; Korytov, A.; Low, J. F.; Ma, P.; Matchev, K.; Mei, H.; Milenovic, P.; Mitselmakher, G.; Muniz, L.; Rank, D.; Rossin, R.; Shchutska, L.; Snowball, M.; Sperka, D.; Wang, J.; Wang, S.; Yelton, J.; Hewamanage, S.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Ackert, A.; Adams, J. R.; Adams, T.; Askew, A.; Bochenek, J.; Diamond, B.; Haas, J.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Khatiwada, A.; Prosper, H.; Veeraraghavan, V.; Weinberg, M.; Bhopatkar, V.; Hohlmann, M.; Kalakhety, H.; Mareskas-Palcek, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Bucinskaite, I.; Cavanaugh, R.; Evdokimov, O.; Gauthier, L.; Gerber, C. E.; Hofman, D. J.; Kurt, P.; O'Brien, C.; Sandoval Gonzalez, I. D.; Silkworth, C.; Turner, P.; Varelas, N.; Wu, Z.; Zakaria, M.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tan, P.; Tiras, E.; Wetzel, J.; Yi, K.; Anderson, I.; Barnett, B. A.; Blumenfeld, B.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Martin, C.; Nash, K.; Osherson, M.; Swartz, M.; Xiao, M.; Xin, Y.; Baringer, P.; Bean, A.; Benelli, G.; Bruner, C.; Gray, J.; Kenny, R. P., III; Majumder, D.; Malek, M.; Murray, M.; Noonan, D.; Sanders, S.; Stringer, R.; Wang, Q.; Wood, J. S.; Chakaberia, I.; Ivanov, A.; Kaadze, K.; Khalil, S.; Makouski, M.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Svintradze, I.; Toda, S.; Lange, D.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Gomez, J. A.; Hadley, N. J.; Jabeen, S.; Kellogg, R. G.; Kolberg, T.; Kunkle, J.; Lu, Y.; Mignerey, A. C.; Shin, Y. H.; Skuja, A.; Tonjes, M. B.; Tonwar, S. C.; Apyan, A.; Barbieri, R.; Baty, A.; Bierwagen, K.; Brandt, S.; Busza, W.; Cali, I. A.; Demiragli, Z.; Di Matteo, L.; Gomez Ceballos, G.; Goncharov, M.; Gulhan, D.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; McGinn, C.; Mironov, C.; Niu, X.; Paus, C.; Ralph, D.; Roland, C.; Roland, G.; Salfeld-Nebgen, J.; Stephans, G. S. F.; Sumorok, K.; Varma, M.; Velicanu, D.; Veverka, J.; Wang, J.; Wang, T. W.; Wyslouch, B.; Yang, M.; Zhukova, V.; Dahmes, B.; Finkel, A.; Gude, A.; Hansen, P.; Kalafut, S.; Kao, S. C.; Klapoetke, K.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Tambe, N.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bloom, K.; Bose, S.; Claes, D. R.; Dominguez, A.; Fangmeier, C.; Gonzalez Suarez, R.; Kamalieddin, R.; Keller, J.; Knowlton, D.; Kravchenko, I.; Lazo-Flores, J.; Meier, F.; Monroy, J.; Ratnikov, F.; Siado, J. E.; Snow, G. R.; Alyari, M.; Dolen, J.; George, J.; Godshalk, A.; Iashvili, I.; Kaisen, J.; Kharchilava, A.; Kumar, A.; Rappoccio, S.; Alverson, G.; Barberis, E.; Baumgartel, D.; Chasco, M.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira de Lima, R.; Trocino, D.; Wang, R.-J.; Wood, D.; Zhang, J.; Hahn, K. A.; Kubik, A.; Mucia, N.; Odell, N.; Pollack, B.; Pozdnyakov, A.; Schmitt, M.; Stoynev, S.; Sung, K.; Trovato, M.; Velasco, M.; Won, S.; Brinkerhoff, A.; Dev, N.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Lynch, S.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Pearson, T.; Planer, M.; Reinsvold, A.; Ruchti, R.; Smith, G.; Taroni, S.; Valls, N.; Wayne, M.; Wolf, M.; Woodard, A.; Antonelli, L.; Brinson, J.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Hart, A.; Hill, C.; Hughes, R.; Kotov, K.; Ling, T. Y.; Liu, B.; Luo, W.; Puigh, D.; Rodenburg, M.; Winer, B. L.; Wulsin, H. W.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Koay, S. A.; Lujan, P.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Palmer, C.; Piroué, P.; Quan, X.; Saka, H.; Stickland, D.; Tully, C.; Werner, J. S.; Zuranski, A.; Malik, S.; Barnes, V. E.; Benedetti, D.; Bortoletto, D.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, K.; Kress, M.; Miller, D. H.; Neumeister, N.; Primavera, F.; Radburn-Smith, B. C.; Shi, X.; Shipsey, I.; Silvers, D.; Sun, J.; Svyatkovskiy, A.; Wang, F.; Xie, W.; Xu, L.; Zablocki, J.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Redjimi, R.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Betchart, B.; Bodek, A.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Goldenzweig, P.; Han, J.; Harel, A.; Hindrichs, O.; Khukhunaishvili, A.; Petrillo, G.; Verzetti, M.; Demortier, L.; Arora, S.; Barker, A.; Chou, J. P.; Contreras-Campana, C.; Contreras-Campana, E.; Duggan, D.; Ferencek, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Lath, A.; Panwalkar, S.; Park, M.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Foerster, M.; Riley, G.; Rose, K.; Spanier, S.; York, A.; Bouhali, O.; Castaneda Hernandez, A.; Dalchenko, M.; de Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Flanagan, W.; Gilmore, J.; Kamon, T.; Krutelyov, V.; Montalvo, R.; Mueller, R.; Osipenkov, I.; Pakhotin, Y.; Patel, R.; Perloff, A.; Roe, J.; Rose, A.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Cowden, C.; Damgov, J.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Undleeb, S.; Volobouev, I.; Appelt, E.; Delannoy, A. G.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Mao, Y.; Melo, A.; Sheldon, P.; Snook, B.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Boutle, S.; Cox, B.; Francis, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Lin, C.; Neu, C.; Wolfe, E.; Wood, J.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Kottachchi Kankanamge Don, C.; Lamichhane, P.; Sturdy, J.; Belknap, D. A.; Carlsmith, D.; Cepeda, M.; Christian, A.; Dasu, S.; Dodd, L.; Duric, S.; Friis, E.; Gomber, B.; Hall-Wilton, R.; Herndon, M.; Hervé, A.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Mohapatra, A.; Ojalvo, I.; Perry, T.; Pierro, G. A.; Polese, G.; Ross, I.; Ruggles, T.; Sarangi, T.; Savin, A.; Sharma, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.; Cms Collaboration

2016-04-01

The first search for a heavy charged vector boson in the final state with a tau lepton and a neutrino is reported, using 19.7 fb-1 of LHC data at √{ s} = 8 TeV. A signal would appear as an excess of events with high transverse mass, where the standard model background is low. No excess is observed. Limits are set on a model in which the W‧ decays preferentially to fermions of the third generation. These results substantially extend previous constraints on this model. Masses below 2.0 to 2.7 TeV are excluded, depending on the model parameters. In addition, the existence of a W‧ boson with universal fermion couplings is excluded at 95% confidence level, for W‧ masses below 2.7 TeV. For further reinterpretation a model-independent limit on potential signals for various transverse mass thresholds is also presented.

Search for sterile neutrino mixing in the νμ → ντ appearance channel with the OPERA detector

NASA Astrophysics Data System (ADS)

Mauri, N.

2016-11-01

The OPERA experiment has observed muon neutrino to tau neutrino oscillations in the atmospheric sector in appearance mode. Five ντ candidate events have been detected, a number consistent with the expectation from the "standard" 3ν framework. Based on this result new limits on the mixing parameters of a massive sterile neutrino have been set. The analysis is performed in the 3+1 neutrino model.

Neutrino trident production: a powerful probe of new physics with neutrino beams.

PubMed

Altmannshofer, Wolfgang; Gori, Stefania; Pospelov, Maxim; Yavin, Itay

2014-08-29

The production of a μ+ μ- pair from the scattering of a muon neutrino off the Coulomb field of a nucleus, known as neutrino trident production, is a subweak process that has been observed in only a couple of experiments. As such, we show that it constitutes an exquisitely sensitive probe in the search for new neutral currents among leptons, putting the strongest constraints on well-motivated and well-hidden extensions of the standard model gauge group, including the one coupled to the difference of the lepton number between the muon and tau flavor, Lμ-Lτ. The new gauge boson Z', increases the rate of neutrino trident production by inducing additional (μγαμ)(νγ(α)ν) interactions, which interfere constructively with the standard model contribution. Existing experimental results put significant restrictions on the parameter space of any model coupled to muon number Lμ, and disfavor a putative resolution to the muon g-2 discrepancy via the loop of Z' for any mass mZ'≳400  MeV. The reach to the models' parameter space can be widened with future searches of the trident production at high-intensity neutrino facilities such as the LBNE.

Limits on muon-neutrino to tau-neutrino oscillations induced by a sterile neutrino state obtained by OPERA at the CNGS beam

NASA Astrophysics Data System (ADS)

Agafonova, N.; Aleksandrov, A.; Anokhina, A.; Aoki, S.; Ariga, A.; Ariga, T.; Bender, D.; Bertolin, A.; Bodnarchuk, I.; Bozza, C.; Brugnera, R.; Buonaura, A.; Buontempo, S.; Büttner, B.; Chernyavsky, M.; Chukanov, A.; Consiglio, L.; D'Ambrosio, N.; De Lellis, G.; De Serio, M.; Del Amo Sanchez, P.; Di Crescenzo, A.; Di Ferdinando, D.; Di Marco, N.; Dmitrievski, S.; Dracos, M.; Duchesneau, D.; Dusini, S.; Dzhatdoev, T.; Ebert, J.; Ereditato, A.; Fini, R. A.; Fukuda, T.; Galati, G.; Garfagnini, A.; Goldberg, J.; Gornushkin, Y.; Grella, G.; Guler, A. M.; Gustavino, C.; Hagner, C.; Hara, T.; Hollnagel, A.; Hosseini, B.; Ishiguro, K.; Jakovcic, K.; Jollet, C.; Kamiscioglu, C.; Kamiscioglu, M.; Kim, J. H.; Kim, S. H.; Kitagawa, N.; Klicek, B.; Kodama, K.; Komatsu, M.; Kose, U.; Kreslo, I.; Lauria, A.; Ljubicic, A.; Longhin, A.; Malgin, A.; Malenica, M.; Mandrioli, G.; Matsuo, T.; Matveev, V.; Mauri, N.; Medinaceli, E.; Meregaglia, A.; Mikado, S.; Monacelli, P.; Montesi, M. C.; Morishima, K.; Muciaccia, M. T.; Naganawa, N.; Naka, T.; Nakamura, M.; Nakano, T.; Nakatsuka, Y.; Niwa, K.; Ogawa, S.; Omura, T.; Ozaki, K.; Paoloni, A.; Paparella, L.; Park, B. D.; Park, I. G.; Pasqualini, L.; Pastore, A.; Patrizii, L.; Pessard, H.; Podgrudkov, D.; Polukhina, N.; Pozzato, M.; Pupilli, F.; Roda, M.; Roganova, T.; Rokujo, H.; Rosa, G.; Ryazhskaya, O.; Sato, O.; Schembri, A.; Shakirianova, I.; Shchedrina, T.; Sheshukov, A.; Shibuya, H.; Shiraishi, T.; Shoziyoev, G.; Simone, S.; Sioli, M.; Sirignano, C.; Sirri, G.; Spinetti, M.; Stanco, L.; Starkov, N.; Stellacci, S. M.; Stipcevic, M.; Strolin, P.; Takahashi, S.; Tenti, M.; Terranova, F.; Tioukov, V.; Tufanli, S.; Vilain, P.; Vladymyrov, M.; Votano, L.; Vuilleumier, J. L.; Wilquet, G.; Wonsak, B.; Yoon, C. S.; Zemskova, S.

2015-06-01

The OPERA experiment, exposed to the CERN to Gran Sasso ν μ beam, collected data from 2008 to 2012. Four oscillated ν τ Charged Current interaction candidates have been detected in appearance mode, which are consistent with ν μ → ν τ oscillations at the atmospheric Δ m 2 within the "standard" three-neutrino framework. In this paper, the OPERA ν τ appearance results are used to derive limits on the mixing parameters of a massive sterile neutrino.

Searches for ultra-high energy neutrinos at the Pierre Auger observatory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alvarez-Muñiz, Jaime; Observatorio Pierre Auger, Av. San Martín Norte 304, 5613 Malargüe

2015-07-15

Neutrinos in the sub-EeV energy range and above can be detected and identified with the Surface Detector array of the Pierre Auger Observatory. The identification can be efficiently done for neutrinos of all flavours interacting in the atmosphere, typically above 60° (downward-going), as well as for “Earth-skimming” neutrino interactions in the case of tau neutrinos (upward-going). Three sets of identification criteria were designed to search for downward-going neutrinos in the zenith angle bins 60° − 75° and 75° − 90° as well as for upward-going neutrinos. The three searches have been recently combined, providing, in the absence of candidates inmore » data from 1 January 04 until 31 December 12, a stringent limit to the diffuse flux of ultra-high energy neutrinos.« less

The Detection Of Neutrino Interactions In The OPERA Experiment: An Update

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patrizii, Laura

2009-12-17

OPERA is a long baseline neutrino oscillation experiment built to provide the final and unambiguous proof of the neutrino oscillation hypothesis in the atmospheric sector by observing {nu}{sub {tau}} emerging from the CNGS {nu}{sub {mu}} beam. The detector is a hybrid apparatus installed in the Hall C of the underground Gran Sasso National Laboratory in Italy. Runs with CNGS neutrinos were successfully carried out in 2007 and 2008. In this paper the detector and the analysis strategy are briefly described and the status of the analysis of the 2008 run events is discussed.

Search for neutrino-induced cascades with five years of AMANDA data

NASA Astrophysics Data System (ADS)

Abbasi, R.; Abdou, Y.; Abu-Zayyad, T.; Actis, O.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Andeen, K.; Auffenberg, J.; Bai, X.; Baker, M.; Barwick, S. W.; Bay, R.; Bazo Alba, J. L.; Beattie, K.; Beatty, J. J.; Bechet, S.; Becker, J. K.; Becker, K.-H.; Benabderrahmane, M. L.; Berdermann, J.; Berghaus, P.; Berley, D.; Bernardini, E.; Bertrand, D.; Besson, D. Z.; Bissok, M.; Blaufuss, E.; Boersma, D. J.; Bohm, C.; Böser, S.; Botner, O.; Bradley, L.; Braun, J.; Buitink, S.; Carson, M.; Chirkin, D.; Christy, B.; Clem, J.; Clevermann, F.; Cohen, S.; Colnard, C.; Cowen, D. F.; D'Agostino, M. V.; Danninger, M.; Davis, J. C.; de Clercq, C.; Demirörs, L.; Depaepe, O.; Descamps, F.; Desiati, P.; de Vries-Uiterweerd, G.; Deyoung, T.; Díaz-Vélez, J. C.; Dreyer, J.; Dumm, J. P.; Duvoort, M. R.; Ehrlich, R.; Eisch, J.; Ellsworth, R. W.; Engdegård, O.; Euler, S.; Evenson, P. A.; Fadiran, O.; Fazely, A. R.; Feusels, T.; Filimonov, K.; Finley, C.; Foerster, M. M.; Fox, B. D.; Franckowiak, A.; Franke, R.; Gaisser, T. K.; Gallagher, J.; Ganugapati, R.; Geisler, M.; Gerhardt, L.; Gladstone, L.; Glüsenkamp, T.; Goldschmidt, A.; Goodman, J. A.; Grant, D.; Griesel, T.; Groß, A.; Grullon, S.; Gunasingha, R. M.; Gurtner, M.; Ha, C.; Hallgren, A.; Halzen, F.; Han, K.; Hanson, K.; Helbing, K.; Herquet, P.; Hickford, S.; Hill, G. C.; Hoffman, K. D.; Homeier, A.; Hoshina, K.; Hubert, D.; Huelsnitz, W.; Hülß, J.-P.; Hulth, P. O.; Hultqvist, K.; Hussain, S.; Imlay, R. L.; Ishihara, A.; Jacobsen, J.; Japaridze, G. S.; Johansson, H.; Joseph, J. M.; Kampert, K.-H.; Kappes, A.; Karg, T.; Karle, A.; Kelley, J. L.; Kemming, N.; Kenny, P.; Kiryluk, J.; Kislat, F.; Klein, S. R.; Knops, S.; Köhne, J.-H.; Kohnen, G.; Kolanoski, H.; Köpke, L.; Koskinen, D. J.; Kowalski, M.; Kowarik, T.; Krasberg, M.; Krings, T.; Kroll, G.; Kuehn, K.; Kuwabara, T.; Labare, M.; Lafebre, S.; Laihem, K.; Landsman, H.; Lauer, R.; Lehmann, R.; Lennarz, D.; Lünemann, J.; Madsen, J.; Majumdar, P.; Maruyama, R.; Mase, K.; Matis, H. S.; Matusik, M.; Meagher, K.; Merck, M.; Mészáros, P.; Meures, T.; Middell, E.; Milke, N.; Miller, J.; Montaruli, T.; Morse, R.; Movit, S. M.; Nahnhauer, R.; Nam, J. W.; Naumann, U.; Nießen, P.; Nygren, D. R.; Odrowski, S.; Olivas, A.; Olivo, M.; Ono, M.; Panknin, S.; Paul, L.; Pérez de Los Heros, C.; Petrovic, J.; Piegsa, A.; Pieloth, D.; Porrata, R.; Posselt, J.; Price, P. B.; Prikockis, M.; Przybylski, G. T.; Rawlins, K.; Redl, P.; Resconi, E.; Rhode, W.; Ribordy, M.; Rizzo, A.; Rodrigues, J. P.; Roth, P.; Rothmaier, F.; Rott, C.; Roucelle, C.; Ruhe, T.; Rutledge, D.; Ruzybayev, B.; Ryckbosch, D.; Sander, H.-G.; Sarkar, S.; Schatto, K.; Schlenstedt, S.; Schmidt, T.; Schneider, D.; Schukraft, A.; Schultes, A.; Schulz, O.; Schunck, M.; Seckel, D.; Semburg, B.; Seo, S. H.; Sestayo, Y.; Seunarine, S.; Silvestri, A.; Slipak, A.; Spiczak, G. M.; Spiering, C.; Stamatikos, M.; Stanev, T.; Stephens, G.; Stezelberger, T.; Stokstad, R. G.; Stoyanov, S.; Strahler, E. A.; Straszheim, T.; Sullivan, G. W.; Swillens, Q.; Taboada, I.; Tamburro, A.; Tepe, A.; Ter-Antonyan, S.; Tilav, S.; Toale, P. A.; Tosi, D.; Turčan, D.; van Eijndhoven, N.; Vandenbroucke, J.; van Overloop, A.; van Santen, J.; Voigt, B.; Walck, C.; Waldenmaier, T.; Wallraff, M.; Walter, M.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wiebe, K.; Wiebusch, C. H.; Wikström, G.; Williams, D. R.; Wischnewski, R.; Wissing, H.; Woschnagg, K.; Xu, C.; Xu, X. W.; Yodh, G.; Yoshida, S.; Zarzhitsky, P.

2011-01-01

We report on the search for electromagnetic and hadronic showers (“cascades”) produced by a diffuse flux of extraterrestrial neutrinos in the AMANDA neutrino telescope. Data for this analysis were recorded during 1001 days of detector livetime in the years 2000-2004. The observed event rates are consistent with the background expectation from atmospheric neutrinos and muons. An upper limit is derived for the diffuse flux of neutrinos of all flavors assuming a flavor ratio of νe:νμ:ντ = 1:1:1 at the detection site. The all-flavor flux of neutrinos with an energy spectrum Φ ∝ E-2 is less than 5.0 × 10-7 GeV s-1 sr-1 cm-2 at a 90% C.L. Here, 90% of the simulated signal would fall within the energy range 40 TeV to 9 PeV. We discuss flux limits in the context of several specific models of extraterrestrial and prompt atmospheric neutrino production.

Resonant scattering and charm showers in ultrahigh-energy neutrino interactions

NASA Technical Reports Server (NTRS)

Wilczek, F.

1985-01-01

Electron antineutrinos with energy of about 7 x 10 to the 6th GeV have much-enhanced cross sections due to W-boson production off electrons. Possible signals due to cosmic-ray sources are estimated. Higher-energy antineutrinos can efficiently produce a W accompanied by radiation. Another possibility, which could lead to shadowing at modest depths, is resonant production of a charged Higgs particle. The importance of muon production by charm showers in rock is pointed out.

Publisher's Note: Search for ultrahigh energy neutrinos in highly inclined events at the Pierre Auger Observatory [Phys. Rev. D 84, 122005 (2011)

NASA Astrophysics Data System (ADS)

Abreu, P.; Aglietta, M.; Ahlers, M.; Ahn, E. J.; Albuquerque, I. F. M.; Allard, D.; Allekotte, I.; Allen, J.; Allison, P.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Anticic, T.; Aramo, C.; Arganda, E.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Bäcker, T.; Badescu, A. M.; Balzer, M.; Barber, K. B.; Barbosa, A. F.; Bardenet, R.; Barroso, S. L. C.; Baughman, B.; Bäuml, J.; Beatty, J. J.; Becker, B. R.; Becker, K. H.; Bellétoile, A.; Bellido, J. A.; Benzvi, S.; Berat, C.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Bohácová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brancus, I.; Brogueira, P.; Brown, W. C.; Bruijn, R.; Buchholz, P.; Bueno, A.; Burton, R. E.; Caballero-Mora, K. S.; Caccianiga, B.; Caramete, L.; Caruso, R.; Castellina, A.; Catalano, O.; Cataldi, G.; Cazon, L.; Cester, R.; Chauvin, J.; Cheng, S. H.; Chiavassa, A.; Chinellato, J. A.; Chirinos Diaz, J.; Chudoba, J.; Clay, R. W.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cook, H.; Cooper, M. J.; Coppens, J.; Cordier, A.; Coutu, S.; Covault, C. E.; Creusot, A.; Criss, A.; Cronin, J.; Curutiu, A.; Dagoret-Campagne, S.; Dallier, R.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Domenico, M.; de Donato, C.; de Jong, S. J.; de La Vega, G.; de Mello, W. J. M., Jr.; de Mello Neto, J. R. T.; de Mitri, I.; de Souza, V.; de Vries, K. D.; Del Peral, L.; Del Río, M.; Deligny, O.; Dembinski, H.; Dhital, N.; di Giulio, C.; Díaz Castro, M. L.; Diep, P. N.; Diogo, F.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; Dos Anjos, J. C.; Dova, M. T.; D'Urso, D.; Dutan, I.; Ebr, J.; Engel, R.; Erdmann, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Facal San Luis, P.; Fajardo Tapia, I.; Falcke, H.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Fick, B.; Filevich, A.; Filipcic, A.; Fliescher, S.; Fracchiolla, C. E.; Fraenkel, E. D.; Fratu, O.; Fröhlich, U.; Fuchs, B.; Gaior, R.; Gamarra, R. F.; Gambetta, S.; García, B.; Garcia Roca, S. T.; Garcia-Gamez, D.; Garcia-Pinto, D.; Gascon, A.; Gemmeke, H.; Ghia, P. L.; Giaccari, U.; Giller, M.; Glass, H.; Gold, M. S.; Golup, G.; Gomez Albarracin, F.; Gómez Berisso, M.; Gómez Vitale, P. F.; Gonçalves, P.; Gonzalez, D.; Gonzalez, J. G.; Gookin, B.; Gorgi, A.; Gouffon, P.; Grashorn, E.; Grebe, S.; Griffith, N.; Grigat, M.; Grillo, A. F.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Guzman, A.; Hansen, P.; Harari, D.; Harmsma, S.; Harrison, T. A.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Herve, A. E.; Hojvat, C.; Hollon, N.; Holmes, V. C.; Homola, P.; Hörandel, J. R.; Horneffer, A.; Horvath, P.; Hrabovský, M.; Huber, D.; Huege, T.; Insolia, A.; Ionita, F.; Italiano, A.; Jarne, C.; Jiraskova, S.; Josebachuili, M.; Kadija, K.; Kampert, K. H.; Karhan, P.; Kasper, P.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kelley, J. L.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Knapp, J.; Koang, D.-H.; Kotera, K.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuehn, F.; Kuempel, D.; Kulbartz, J. K.; Kunka, N.; La Rosa, G.; Lachaud, C.; Lauer, R.; Lautridou, P.; Le Coz, S.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Lopez Agüera, A.; Louedec, K.; Lozano Bahilo, J.; Lu, L.; Lucero, A.; Ludwig, M.; Lyberis, H.; Macolino, C.; Maldera, S.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, J.; Marin, V.; Maris, I. C.; Marquez Falcon, H. R.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Martínez Bravo, O.; Mathes, H. J.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurel, D.; Maurizio, D.; Mazur, P. O.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Mertsch, P.; Meurer, C.; Micanovic, S.; Micheletti, M. I.; Miramonti, L.; Molina-Bueno, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morales, B.; Morello, C.; Moreno, E.; Moreno, J. C.; Mostafá, M.; Moura, C. A.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Neuser, J.; Newton, D.; Nhung, P. T.; Niechciol, M.; Niemietz, L.; Nierstenhoefer, N.; Nitz, D.; Nosek, D.; Nožka, L.; Nyklicek, M.; Oehlschläger, J.; Olinto, A.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Parente, G.; Parizot, E.; Parra, A.; Pastor, S.; Paul, T.; Pech, M.; Pekala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Petrera, S.; Petrinca, P.; Petrolini, A.; Petrov, Y.; Pfendner, C.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Ponce, V. H.; Pontz, M.; Porcelli, A.; Privitera, P.; Prouza, M.; Quel, E. J.; Querchfeld, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rivera, H.; Rizi, V.; Roberts, J.; Rodrigues de Carvalho, W.; Rodriguez, G.; Rodriguez Martino, J.; Rodriguez Rojo, J.; Rodriguez-Cabo, I.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Rouillé-D'Orfeuil, B.; Roulet, E.; Rovero, A. C.; Rühle, C.; Saftoiu, A.; Salamida, F.; Salazar, H.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarkar, S.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Scholten, O.; Schoorlemmer, H.; Schovancova, J.; Schovánek, P.; Schröder, F.; Schulte, S.; Schuster, D.; Sciutto, S. J.; Scuderi, M.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Silva Lopez, H. H.; Sima, O.; Smialkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Spinka, H.; Squartini, R.; Srivastava, Y. N.; Stanic, S.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Šuša, T.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Tapia, A.; Tartare, M.; Tascau, O.; Tavera Ruiz, C. G.; Tcaciuc, R.; Tegolo, D.; Thao, N. T.; Thomas, D.; Tiffenberg, J.; Timmermans, C.; Tkaczyk, W.; Todero Peixoto, C. J.; Toma, G.; Tomé, B.; Tonachini, A.; Travnicek, P.; Tridapalli, D. B.; Tristram, G.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van den Berg, A. M.; Varela, E.; Vargas Cárdenas, B.; Vázquez, J. R.; Vázquez, R. A.; Veberic, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Wahlberg, H.; Wahrlich, P.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Werner, F.; Westerhoff, S.; Whelan, B. J.; Widom, A.; Wieczorek, G.; Wiencke, L.; Wilczynska, B.; Wilczynski, H.; Will, M.; Williams, C.; Winchen, T.; Wommer, M.; Wundheiler, B.; Yamamoto, T.; Yapici, T.; Younk, P.; Yuan, G.; Yushkov, A.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Zhu, Y.; Zimbres Silva, M.; Ziolkowski, M.

2012-01-01

The Surface Detector of the Pierre Auger Observatory is sensitive to neutrinos of all flavours above 0.1 EeV. These interact through charged and neutral currents in the atmosphere giving rise to extensive air showers. When interacting deeply in the atmosphere at nearly horizontal incidence, neutrinos can be distinguished from regular hadronic cosmic rays by the broad time structure of their shower signals in the water-Cherenkov detectors. In this paper we present for the first time an analysis based on down-going neutrinos. We describe the search procedure, the possible sources of background, the method to compute the exposure and the associated systematic uncertainties. No candidate neutrinos have been found in data collected from 1 January 2004 to 31 May 2010. Assuming an E^-2 differential energy spectrum the limit on the single flavour neutrino is (E^2 * dN/dE) < 1.74x10^-7 GeV cm^-2 s^-1 sr^-1 at 90% C.L. in the energy range 1x10^17 eV < E < 1x10^20 eV.

Search for PeVatrons at the Galactic Center using a radio air-shower array at the South Pole

NASA Astrophysics Data System (ADS)

Balagopal V., A.; Haungs, A.; Huege, T.; Schröder, F. G.

2018-02-01

The South Pole, which hosts the IceCube Neutrino Observatory, has a complete and around-the-clock exposure to the Galactic Center. Hence, it is an ideal location to search for gamma rays of PeV energy coming from the Galactic Center. However, it is hard to detect air showers initiated by these gamma rays using cosmic-ray particle detectors due to the low elevation of the Galactic Center. The use of antennas to measure the radio footprint of these air showers will help in this case, and would allow for a 24/7 operation time. So far, only air showers with energies well above 10^{16} eV have been detected with the radio technique. Thus, the energy threshold has to be lowered for the detection of gamma-ray showers of PeV energy. This can be achieved by optimizing the frequency band in order to obtain a higher level of signal-to-noise ratio. With such an approach, PeV gamma-ray showers with high inclination can be measured at the South Pole.

Study of charged hadron multiplicities in charged-current neutrino-lead interactions in the OPERA detector

NASA Astrophysics Data System (ADS)

Agafonova, N.; Aleksandrov, A.; Anokhina, A.; Aoki, S.; Ariga, A.; Ariga, T.; Bertolin, A.; Bodnarchuk, I.; Bozza, C.; Brugnera, R.; Buonaura, A.; Buontempo, S.; Chernyavskiy, M.; Chukanov, A.; Consiglio, L.; D'Ambrosio, N.; De Lellis, G.; De Serio, M.; del Amo Sanchez, P.; Di Crescenzo, A.; Di Ferdinando, D.; Di Marco, N.; Dmitrievski, S.; Dracos, M.; Duchesneau, D.; Dusini, S.; Dzhatdoev, T.; Ebert, J.; Ereditato, A.; Fini, R. A.; Fornari, F.; Fukuda, T.; Galati, G.; Garfagnini, A.; Gentile, V.; Goldberg, J.; Gornushkin, Y.; Gorbunov, S.; Grella, G.; Guler, A. M.; Gustavino, C.; Hagner, C.; Hara, T.; Hayakawa, T.; Hollnagel, A.; Hosseini, B.; Ishiguro, K.; Jakovcic, K.; Jollet, C.; Kamiscioglu, C.; Kamiscioglu, M.; Kim, S. H.; Kitagawa, N.; Klicek, B.; Kodama, K.; Komatsu, M.; Kose, U.; Kreslo, I.; Laudisio, F.; Lauria, A.; Ljubicic, A.; Longhin, A.; Loverre, P.; Malgin, A.; Malenica, M.; Mandrioli, G.; Matsuo, T.; Matveev, V.; Mauri, N.; Medinaceli, E.; Meregaglia, A.; Mikado, S.; Miyanishi, M.; Mizutani, F.; Monacelli, P.; Montesi, M. C.; Morishima, K.; Muciaccia, M. T.; Naganawa, N.; Naka, T.; Nakamura, M.; Nakano, T.; Niwa, K.; Okateva, N.; Ogawa, S.; Ozaki, K.; Paoloni, A.; Paparella, L.; Park, B. D.; Pasqualini, L.; Pastore, A.; Patrizii, L.; Pessard, H.; Podgrudkov, D.; Polukhina, N.; Pozzato, M.; Pupilli, F.; Roda, M.; Roganova, T.; Rokujo, H.; Rosa, G.; Ryazhskaya, O.; Sato, O.; Schembri, A.; Shakirianova, I.; Shchedrina, T.; Shibuya, H.; Shibayama, E.; Shiraishi, T.; Simone, S.; Sirignano, C.; Sirri, G.; Sotnikov, A.; Spinetti, M.; Stanco, L.; Starkov, N.; Stellacci, S. M.; Stipcevic, M.; Strolin, P.; Takahashi, S.; Tenti, M.; Terranova, F.; Tioukov, V.; Vasina, S.; Vilain, P.; Voevodina, E.; Votano, L.; Vuilleumier, J. L.; Wilquet, G.; Wonsak, B.; Yoon, C. S.

2018-01-01

The OPERA experiment was designed to search for ν _{μ } → ν _{τ } oscillations in appearance mode through the direct observation of tau neutrinos in the CNGS neutrino beam. In this paper, we report a study of the multiplicity of charged particles produced in charged-current neutrino interactions in lead. We present charged hadron average multiplicities, their dispersion and investigate the KNO scaling in different kinematical regions. The results are presented in detail in the form of tables that can be used in the validation of Monte Carlo generators of neutrino-lead interactions.

Cosmic Ray-Air Shower Measurement from Space

NASA Technical Reports Server (NTRS)

Takahashi, Yoshiyuki

1997-01-01

A feasibility study has been initiated to observe from space the highest energy cosmic rays above 1021 eV. A satellite observatory concept, the Maximum-energy Auger (Air)-Shower Satellite (MASS), is recently renamed as the Orbital Wide-angle Collector (OWL) by taking its unique feature of using a very wide field-of-view (FOV) optics. A huge array of imaging devices (about 10(exp 6) pixels) is required to detect and record fluorescent light profiles of cosmic ray cascades in the atmosphere. The FOV of MASS could extend to as large as about 60 in. diameter, which views (500 - 1000 km) of earth's surface and more than 300 - 1000 cosmic ray events per year could be observed above 1020 eV. From far above the atmosphere, the MASS/OWL satellite should be capable of observing events at all angles including near horizontal tracks, and would have considerable aperture for high energy photon and neutrino observation. With a large aperture and the spatial and temporal resolution, MASS could determine the energy spectrum, the mass composition, and arrival anisotropy of cosmic rays from 1020 eV to 1022 eV; a region hitherto not explored by ground-based detectors such as the Fly's Eye and air-shower arrays. MASS/OWL's ability to identify cosmic neutrinos and gamma rays may help providing evidence for the theory which attributes the above cut-off cosmic ray flux to the decay of topological defects. Very wide FOV optics system of MASS/OWL with a large array of imaging devices is applicable to observe other atmospheric phenomena including upper atmospheric lightning. The wide FOV MASS optics being developed can also improve ground-based gamma-ray observatories by allowing simultaneous observation of many gamma ray sources located at different constellations.

Tau lepton polarization in quasielastic neutrino-nucleon scattering

NASA Astrophysics Data System (ADS)

Kuzmin, Konstantin S.; Lyubushkin, Vladimir V.; Naumov, Vadim A.

2005-02-01

We derive structure functions for the quasielastic production of octet baryons in νn and νp interactions and study the polarization of τ leptons produced in the ΔY=0 reactions. Possible impact of the charged second-class currents is investigated by adopting a simple phenomenological parametrization for the nonstandard scalar and tensor nucleon form factors. Our choice of the unknown parameters is made to satisfy the limits obtained in the (anti)neutrino scattering experiments and rigid restrictions derived from the nuclear structure studies.

A sterile neutrino at MiniBooNE and IceCube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Masip, Manuel

We discuss the possibility that a sterile neutrino of mass around 50 MeV slightly mixed with the muon flavor may be the origin of the MiniBooNE anomaly. We show that its production in the atmosphere in a fraction of kaon decays would imply an excess of contained showers at IceCube from down-going and near-horizontal directions.

All-flavor Search for a Diffuse Flux of Cosmic Neutrinos with Nine Years of ANTARES Data

NASA Astrophysics Data System (ADS)

Albert, A.; André, M.; Anghinolfi, M.; Anton, G.; Ardid, M.; Aubert, J.-J.; Aublin, J.; Avgitas, T.; Baret, B.; Barrios-Martí, J.; Basa, S.; Belhorma, B.; Bertin, V.; Biagi, S.; Bormuth, R.; Bourret, S.; Bouwhuis, M. C.; Brânzaş, H.; Bruijn, R.; Brunner, J.; Busto, J.; Capone, A.; Caramete, L.; Carr, J.; Celli, S.; Cherkaoui El Moursli, R.; Chiarusi, T.; Circella, M.; Coelho, J. A. B.; Coleiro, A.; Coniglione, R.; Costantini, H.; Coyle, P.; Creusot, A.; Díaz, A. F.; Deschamps, A.; De Bonis, G.; Distefano, C.; Di Palma, I.; Domi, A.; Donzaud, C.; Dornic, D.; Drouhin, D.; Eberl, T.; El Bojaddaini, I.; El Khayati, N.; Elsässer, D.; Enzenhöfer, A.; Ettahiri, A.; Fassi, F.; Felis, I.; Fusco, L. A.; Gay, P.; Giordano, V.; Glotin, H.; Grégoire, T.; Ruiz, R. Gracia; Graf, K.; Hallmann, S.; van Haren, H.; Heijboer, A. J.; Hello, Y.; Hernández-Rey, J. J.; Hößl, J.; Hofestädt, J.; Illuminati, G.; James, C. W.; de Jong, M.; Jongen, M.; Kadler, M.; Kalekin, O.; Katz, U.; Kießling, D.; Kouchner, A.; Kreter, M.; Kreykenbohm, I.; Kulikovskiy, V.; Lachaud, C.; Lahmann, R.; Lefèvre, D.; Leonora, E.; Lotze, M.; Loucatos, S.; Marcelin, M.; Margiotta, A.; Marinelli, A.; Martínez-Mora, J. A.; Mele, R.; Melis, K.; Michael, T.; Migliozzi, P.; Moussa, A.; Navas, S.; Nezri, E.; Organokov, M.; Păvălaş, G. E.; Pellegrino, C.; Perrina, C.; Piattelli, P.; Popa, V.; Pradier, T.; Quinn, L.; Racca, C.; Riccobene, G.; Sánchez-Losa, A.; Saldaña, M.; Salvadori, I.; Samtleben, D. F. E.; Sanguineti, M.; Sapienza, P.; Schüssler, F.; Sieger, C.; Spurio, M.; Stolarczyk, Th.; Taiuti, M.; Tayalati, Y.; Trovato, A.; Turpin, D.; Tönnis, C.; Vallage, B.; Van Elewyck, V.; Versari, F.; Vivolo, D.; Vizzoca, A.; Wilms, J.; Zornoza, J. D.; Zúñiga, J.; (The ANTARES Collaboration

2018-01-01

The ANTARES detector is at present the most sensitive neutrino telescope in the northern hemisphere. The highly significant cosmic neutrino excess observed by the Antarctic IceCube detector can be studied with ANTARES, exploiting its complementing field of view, exposure, and lower energy threshold. Searches for an all-flavor diffuse neutrino signal, covering nine years of ANTARES data taking, are presented in this Letter. Upward-going events are used to reduce the atmospheric muon background. This work includes for the first time in ANTARES both track-like (mainly {ν }μ ) and shower-like (mainly {ν }e) events in this kind of analysis. Track-like events allow for an increase of the effective volume of the detector thanks to the long path traveled by muons in rock and/or sea water. Shower-like events are well reconstructed only when the neutrino interaction vertex is close to, or inside, the instrumented volume. A mild excess of high-energy events over the expected background is observed in nine years of ANTARES data in both samples. The best fit for a single power-law cosmic neutrino spectrum, in terms of per-flavor flux at 100 TeV, is {{{Φ }}}01f(100 {{TeV}})=(1.7+/- 1.0)× 10‑18 GeV‑1 cm‑2 s‑1 sr‑1 with spectral index {{Γ }}={2.4}-0.4+0.5. The null cosmic flux assumption is rejected with a significance of 1.6σ.

Hadron production measurements for neutrino physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Panman, Jaap

2008-02-21

One of the limiting factors for the precision of neutrino oscillation experiments is the uncertainty in the composition and spectrum of the neutrino flux. Recently, dedicated hadron production experiments have been taking data and are being planned to supply measurements which can significantly reduce these uncertainties. The HARP experiment has presented results on the measurements of the double-differential production cross-section of charged pions in proton interactions with beryllium, carbon, aluminium, copper, tin, tantalum and lead targets. These results are relevant for a detailed understanding of neutrino flux in accelerator neutrino experiments K2K (p-Al data) and MiniBooNE/SciBooNE (p-Be data), for amore » better prediction of atmospheric neutrino fluxes (p-C, {pi}{sup +}-C and {pi}{sup -}-C data) as well as for a systematic improvement of hadron production models. The E910 experiment at BNL has recently published their p-Be data. NA49 has measured pion production spectra in p-C interactions and a new experiment, NA61, is starting to take data using essentially the same detector. NA61 plans to measure production spectra for the T2K experiment and for the calculation of extended air showers. MIPP has taken data with a copy of the NuMI target and is progressing in the analysis of these data. An upgrade of the readout of this experiment can greatly increase its potential.« less

Solar atmospheric neutrinos and the sensitivity floor for solar dark matter annihilation searches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Argüelles, C.A.; De Wasseige, G.; Fedynitch, A.

Cosmic rays interacting in the solar atmosphere produce showers that result in a flux of high-energy neutrinos from the Sun. These form an irreducible background to indirect solar WIMP self-annihilation searches, which look for heavy dark matter particles annihilating into final states containing neutrinos in the Solar core. This background will eventually create a sensitivity floor for indirect WIMP self-annihilation searches analogous to that imposed by low-energy solar neutrino interactions for direct dark matter detection experiments. We present a new calculation of the flux of solar atmospheric neutrinos with a detailed treatment of systematic uncertainties inherent in solar atmospheric showermore » evolution, and we use this to derive the sensitivity floor for indirect solar WIMP annihilation analyses. We find that the floor lies less than one order of magnitude beyond the present experimental limits on spin-dependent WIMP-proton cross sections for some mass points, and that the high-energy solar atmospheric neutrino flux may be observable with running and future neutrino telescopes.« less

Stochastic mass-reconstruction: a new technique to reconstruct resonance masses of heavy particles decaying into tau lepton pairs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maruyama, Sho

2015-12-15

The invariant mass of tau lepton pairs turns out to be smaller than the resonant mass of their mother particle and the invariant mass distribution is stretched wider than the width of the resonant mass as significant fraction of tau lepton momenta are carried away by neutrinos escaping undetected at collider experiments. This paper describes a new approach to reconstruct resonant masses of heavy particles decaying to tau leptons at such experiments. A typical example is a Z or Higgs boson decaying to a tau pair. Although the new technique can be used for each tau lepton separately, I combinemore » two tau leptons to improve mass resolution by requiring the two tau leptons are lined up in a transverse plane. The method is simple to implement and complementary to the collinear approximation technique that works well when tau leptons are not lined up in a transverse plane. The reconstructed mass can be used as another variable in analyses that already use a visible tau pair mass and missing transverse momentum as these variables are not explicitly used in the stochastic mass-reconstruction to select signal-like events.« less

Thermal dark matter through the Dirac neutrino portal

NASA Astrophysics Data System (ADS)

Batell, Brian; Han, Tao; McKeen, David; Haghi, Barmak Shams Es

2018-04-01

We study a simple model of thermal dark matter annihilating to standard model neutrinos via the neutrino portal. A (pseudo-)Dirac sterile neutrino serves as a mediator between the visible and the dark sectors, while an approximate lepton number symmetry allows for a large neutrino Yukawa coupling and, in turn, efficient dark matter annihilation. The dark sector consists of two particles, a Dirac fermion and complex scalar, charged under a symmetry that ensures the stability of the dark matter. A generic prediction of the model is a sterile neutrino with a large active-sterile mixing angle that decays primarily invisibly. We derive existing constraints and future projections from direct detection experiments, colliders, rare meson and tau decays, electroweak precision tests, and small scale structure observations. Along with these phenomenological tests, we investigate the consequences of perturbativity and scalar mass fine tuning on the model parameter space. A simple, conservative scheme to confront the various tests with the thermal relic target is outlined, and we demonstrate that much of the cosmologically-motivated parameter space is already constrained. We also identify new probes of this scenario such as multibody kaon decays and Drell-Yan production of W bosons at the LHC.

Studies of mu-neutrino going to e-neutrino oscillation appearance in the MINOS experiment

NASA Astrophysics Data System (ADS)

Sousa, Alexandre Bruno Pereira E.

The MINOS experiment uses a long baseline neutrino beam, measured 1 km downstream from its origin in the Near Detector at Fermilab, and 734 km later in the large underground Far Detector in the Soudan mine. By comparing these two measurements, MINOS can probe the atmospheric domain of the neutrino oscillation phenomenology with unprecedented precision. Besides the ability to perform a world leading determination of the Dm223 and theta23 parameters, via numu flux disappearance, MINOS has the potential to make a leading measurement of nu mu → nue oscillations in the atmospheric sector by looking for nue appearance at the Far Detector. The observation of nue appearance, tantamount to establishing a non-zero value of the theta13 mixing angle, opens the way to studies of CP violation in the leptonic sector, the neutrino spectral mass pattern ordering and neutrino oscillations in matter, the driving motivations of the next generation of neutrino experiments. In this thesis, we study the MINOS potential for measuring theta13 in the context of the MINOS Mock Data Challenge using a multivariate discriminant analysis method. We show the method's validity in the application to nue event classification and background identification, as well as in its ability to identify a nue signal in a Mock Data sample generated with undisclosed parameters. An independent shower reconstruction method based on three-dimensional hit matching and clustering was developed, providing several useful discriminator variables used in the multivariate analysis method. We also demonstrate that within 2 years of running, MINOS has the potential to improve the current best limit on theta 13, from the CHOOZ experiment, by a factor of 2.

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers.

PubMed

Rubenstein, Richard; Chang, Binggong; Yue, John K; Chiu, Allen; Winkler, Ethan A; Puccio, Ava M; Diaz-Arrastia, Ramon; Yuh, Esther L; Mukherjee, Pratik; Valadka, Alex B; Gordon, Wayne A; Okonkwo, David O; Davies, Peter; Agarwal, Sanjeev; Lin, Fan; Sarkis, George; Yadikar, Hamad; Yang, Zhihui; Manley, Geoffrey T; Wang, Kevin K W; Cooper, Shelly R; Dams-O'Connor, Kristen; Borrasso, Allison J; Inoue, Tomoo; Maas, Andrew I R; Menon, David K; Schnyer, David M; Vassar, Mary J

2017-09-01

Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated. To examine the associations between plasma P-tau and total-tau (T-tau) levels and injury presence, severity, type of pathoanatomic lesion (neuroimaging), and patient outcomes in acute and chronic TBI. In the TRACK-TBI Pilot study, plasma was collected at a single time point from 196 patients with acute TBI admitted to 3 level I trauma centers (<24 hours after injury) and 21 patients with TBI admitted to inpatient rehabilitation units (mean [SD], 176.4 [44.5] days after injury). Control samples were purchased from a commercial vendor. The TRACK-TBI Pilot study was conducted from April 1, 2010, to June 30, 2012. Data analysis for the current investigation was performed from August 1, 2015, to March 13, 2017. Plasma samples were assayed for P-tau (using an antibody that specifically recognizes phosphothreonine-231) and T-tau using ultra-high sensitivity laser-based immunoassay multi-arrayed fiberoptics conjugated with rolling circle amplification. In the 217 patients with TBI, 161 (74.2%) were men; mean (SD) age was 42.5 (18.1) years. The P-tau and T-tau levels and P-tau-T-tau ratio in patients with acute TBI were higher than those in healthy controls. Receiver operating characteristic analysis for the 3 tau indices demonstrated accuracy with area under the curve (AUC) of 1.000, 0.916, and 1.000, respectively, for discriminating mild TBI (Glasgow Coma Scale [GCS] score, 13-15, n = 162) from healthy controls. The P-tau level and P-tau-T-tau ratio were higher in individuals with more severe TBI (GCS, ≤12 vs 13-15). The P-tau level and P-tau-T-tau

To determine ice layer thickness of Europa by high energy neutrino

NASA Astrophysics Data System (ADS)

Shoji, D.; Kurita, K.; Tanaka, H. K.

2010-12-01

Europa, the second closest Galilean satellite is one of the targets which are suspected to have an internal ocean. Detection and characterization of the internal ocean is one of the main subjects for Europa orbiter exploration. Although the gravitational data has shown the thickness of the surface H2O layer of 80-170km[1], it can not determine the phase of H2O. The variations in the magnetic field associated with the induced current in the internal ocean can determine the thickness of the layer of ice if satellite's orbits satisfy the required conditions. Observations of tidal amplitude forced by Jupiter can also resolve the thickness of the surface lithosphere[2]. At moment because of the lack of observational constraints there exist two contrasting models:thick ice layer model and thin model. Here we propose new method to detect the ocean directly based on the radiation by high energy neutrino interacted with matter. Schaefer et al[3] have proposed a similar method to determine ice layer thickness. We will focus on the detection of internal ocean for Europa and present the method is suitable for actual situations of Europa exploration by numerical simulations. Neutrino is famous for its traveling at long distance without any interaction with matter. When high energy neutrinos traverse in Europa hadronic showers are produced by the weak interaction with the nucleons that makes the body of Europa. These hadronic showers induces excess electrons. Because of these excess electrons, Cherenkov photons are emitted. When this radiation occurs in the ice layer, radiations whose wave length is over 10cm should be coherent because the scale of the shower becomes small (a few cm) in the ice, which is called as Askaryan effect[3]. Thus, the intensity of the radiation whose frequency is a few GHz should be enhanced. Since ice has a much longer attenuation length than water, the radiations which occur in the surface ice layer could be detected by the antenna outside Europa but

Measurement of Neutrino and Antineutrino Charged-Current Inclusive Cross Sections with the MINERvA Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devan, Joshua D.

2015-01-01

Neutrinos are a nearly massless, neutral particle in the Standard Model that only interact via the weak interaction. Experimental confirmation of neutrino oscillations, in which a neutrino created as a particular type (electron, muon or tau) can be observed as a different type after propagating some distance, earned the 2015 Nobel Prize in Physics. Neutrino oscillation experiments rely on accurate measurements of neutrino interactions with matter, such as that presented here. Neutrinos also provide a unique probe of the nucleus, complementary to electron scattering experiments. This thesis presents a measurement of the charged-current inclusive cross section for muon neutrinos and antineutrinos in the energy range 2 to 50 GeV with the MINERvA detector. MINERvA is a neutrino scattering experiment in the NuMI neutrino beam at Fermilab, near Chicago. A cross section measures the probability of an interaction occurring, measured here as a function of neutrino energy. To extract a cross section from data, the observed rate of interactions is corrected for detector efficiency and divided by the number of scattering nucleons in the target and the flux of neutrinos in the beam. The neutrino flux is determined with the low-more » $$\

Flavor revolution at IceCube horizons?

NASA Astrophysics Data System (ADS)

Fargion, Daniele; Paggi, Paolo

2014-07-01

The highest-energy neutrino events identified so far were detected by the IceCube telescope between May and November 2013. Most of these events (21 out of 28) are cascade showers whose flux exhibits sharp hardening with respect to other lower-energy atmospheric neutrino components. These events suggest an injection of extraterrestrial neutrinos, mostly νe and ντ, making cascades. According to the IceCube consortium, a (10.63.6+5.0) component of these events must be a trace of expected downward muons and/or atmospheric neutrinos (mostly dominated by muon tracks). This implies that nearly all of the muon tracks observed (at least 6 of the 7) must be themselves of atmospheric origin. Therefore, the remaining 16-18 extraterrestrial events must be of mostly electron or tau flavor (or rare neutral current (NC) events). The probability of this scenario is very low (approx. 0.1-0.5%). This νμνbarμ paucity paradox cannot be solved if some or even all of the events are induced by terrestrially prompted charm signals, because the probability of this scenario is still less than 1.31%. The paradox might be solved if nearly all of the 28 events originate from extraterrestrial sources arriving in decoherent states. At first sight a partial flavor solution may arise if the highest-energy events at Eν > 60 TeV (17 showers vs 4 muon tracks) are mostly of extraterrestrial origin. However, this still leaves the problem of the earlier 30-60-TeV energy region, for which the eight showers and three tracks are in more in tension with most atmospheric neutrino signals, by a sharp difference at TeV energy ruled (as shown by Deep Core data) by 10 over one neutrino (muon) events over showers. This puzzling (fast) transition from an atmospheric νμνbarμ flux at TeV to tens of TeV has deep consequences: more abundant 10-TeV extraterrestrial neutrino maps may provide a better insight into astronomical clustering and sky anisotropy. In addition, counting of vertical vs horizontal

Radio-wave detection of ultra-high-energy neutrinos and cosmic rays

NASA Astrophysics Data System (ADS)

Huege, Tim; Besson, Dave

2017-12-01

Radio waves, perhaps because our terrestrial atmosphere and the cosmos beyond are uniquely transparent to them, or perhaps because they are macroscopic, so the basic instruments of detection (antennas) are easily constructible, arguably occupy a privileged position within the electromagnetic spectrum, and, correspondingly, receive disproportionate attention experimentally. Detection of radio-frequency radiation, at macroscopic wavelengths, has blossomed within the last decade as a competitive method for the measurement of cosmic particles, particularly charged cosmic rays and neutrinos. Cosmic-ray detection via radio emission from extensive air showers has been demonstrated to be a reliable technique that has reached a reconstruction quality of the cosmic-ray parameters competitive with more traditional approaches. Radio detection of neutrinos in dense media seems to be the most promising technique to achieve the gigantic detection volumes required to measure neutrinos at energies beyond the PeV-scale flux established by IceCube. In this article, we review radio detection both of cosmic rays in the atmosphere, as well as neutrinos in dense media.

Various meteor scenes III: Recurrent showers and some minor showers

NASA Astrophysics Data System (ADS)

Koseki, Masahiro

2015-02-01

Meteor activities vary widely from year to year. We study here the June Bootids (JBO), τ-Herculids (TAH), and Andromedids (AND) which are basic examples for the recurrent nature of meteor showers. Half a century has passed since well-known photographic or radar meteor showers were detected. It is necessary to note that some `established' IAU showers are historical ones and we cannot always see them. We find the historical trace of AND by video and four distinct activities in the area of JBC (=JBO+TAH). Meteor showers look different by different observational techniques. Many minor showers in the IAU list have been detected only by observations stored for many days and many years; visual observations in a single night cannot perceive them naturally. We studied the φ-Piscids (PPS), χ-Taurids (CTA), γ-Ursae Minorids (GUM), η-Pegasids (ETP), and α-Sextantids (ASX) as examples and found they have not been recognized by visual observers at all. It is noteworthy that some of them have possible identifications in the IAU list and in preceding observations or reports. The difference in search methods makes the situations much more complicated. The five minor showers we studied here do not have confirmations by all observational techniques. Geobased search (radiant point, time of the observation, and possibly geocentric velocity) may overlook showers which are dispersed in radiant position. A search using the D-criterion is dependent on the presumption of a spherical distribution in the orbital space and may not represent the real distribution, or may overestimate the accuracy of the observations and lead to subdividing the showers into several parts. We must use these search methods properly.

Three flavor neutrino oscillations in matter: Flavor diagonal potentials, the adiabatic basis, and the CP phase

NASA Astrophysics Data System (ADS)

Kneller, James P.; McLaughlin, Gail C.

2009-09-01

We discuss the three neutrino flavor evolution problem with general, flavor-diagonal, matter potentials and a fully parametrized mixing matrix that includes CP violation, and derive expressions for the eigenvalues, mixing angles, and phases. We demonstrate that, in the limit that the mu and tau potentials are equal, the eigenvalues and matter mixing angles θ˜12 and θ˜13 are independent of the CP phase, although θ˜23 does have CP dependence. Since we are interested in developing a framework that can be used for S matrix calculations of neutrino flavor transformation, it is useful to work in a basis that contains only off-diagonal entries in the Hamiltonian. We derive the “nonadiabaticity” parameters that appear in the Hamiltonian in this basis. We then introduce the neutrino S matrix, derive its evolution equation and the integral solution. We find that this new Hamiltonian, and therefore the S matrix, in the limit that the μ and τ neutrino potentials are the same, is independent of both θ˜23 and the CP violating phase. In this limit, any CP violation in the flavor basis can only be introduced via the rotation matrices, and so effects which derive from the CP phase are then straightforward to determine. We then show explicitly that the electron neutrino and electron antineutrino survival probability is independent of the CP phase in this limit. Conversely, if the CP phase is nonzero and mu and tau matter potentials are not equal, then the electron neutrino survival probability cannot be independent of the CP phase.

High-energy neutrinos from multibody decaying dark matter

NASA Astrophysics Data System (ADS)

Hiroshima, Nagisa; Kitano, Ryuichiro; Kohri, Kazunori; Murase, Kohta

2018-01-01

Since the report of the PeV-TeV neutrinos by the IceCube Collaboration, various particle physics models have been proposed to explain the neutrino spectrum by dark matter particles decaying into neutrinos and other standard model particles. In such scenarios, simultaneous γ -ray emission is commonly expected. Therefore, multimessenger connections are generally important for the indirect searches of dark matters. The recent development of γ -ray astronomy puts stringent constraints on the properties of dark matter, especially by observations with the Fermi γ -ray satellite in the last several years. Motivated by the lack of γ -ray as well as the shape of the neutrino spectrum observed by IceCube, we discuss a scenario in which the DM is a PeV scale particle which couples strongly to other invisible particles and its decay products do not contain a charged particle. As an example to realize such possibilities, we consider a model of fermionic dark matter that decays into a neutrino and many invisible fermions. The dark matter decay is secluded in the sense that the emitted products are mostly neutrinos and dark fermions. One remarkable feature of this model is the resulting broadband neutrino spectra around the energy scale of the dark matter. We apply this model to multi-PeV dark matter, and discuss possible observable consequences in light of the IceCube data. In particular, this model could account for the large flux at medium energies of ˜10 - 100 TeV , possibly as well as the second peak at PeV, without violating the stringent γ -ray constraints from Fermi and air-shower experiments such as CASA-MIA.

Meteor showers in review

NASA Astrophysics Data System (ADS)

Jenniskens, Peter

2017-09-01

Recent work on meteor showers is reviewed. New data is presented on the long duration showers that wander in sun-centered ecliptic coordinates. Since the early days of meteor photography, much progress has been made in mapping visual meteor showers, using low-light video cameras instead. Now, some 820,000 meteoroid orbits have been measured by four orbit surveys during 2007-2015. Mapped in sun-centered ecliptic coordinates in 5° intervals of solar longitude, the data show a number of long duration (>15 days) meteor showers that have drifting radiants and speeds with solar longitude. 18 showers emerge from the antihelion source and follow a drift pattern towards high ecliptic latitudes. 27 Halley-type showers in the apex source move mostly towards lower ecliptic longitudes, but those at high ecliptic latitudes move backwards. Also, 5 low-speed showers appear between the toroidal ring and the apex source, moving towards the antihelion source. Most other showers do not last long, or do not move much in sun-centered ecliptic coordinates. The surveys also detected episodic showers, which mostly document the early stages of meteoroid stream formation. New data on the sporadic background have shed light on the dynamical evolution of the zodiacal cloud.

Separation and confirmation of showers

NASA Astrophysics Data System (ADS)

Neslušan, L.; Hajduková, M.

2017-02-01

Aims: Using IAU MDC photographic, IAU MDC CAMS video, SonotaCo video, and EDMOND video databases, we aim to separate all provable annual meteor showers from each of these databases. We intend to reveal the problems inherent in this procedure and answer the question whether the databases are complete and the methods of separation used are reliable. We aim to evaluate the statistical significance of each separated shower. In this respect, we intend to give a list of reliably separated showers rather than a list of the maximum possible number of showers. Methods: To separate the showers, we simultaneously used two methods. The use of two methods enables us to compare their results, and this can indicate the reliability of the methods. To evaluate the statistical significance, we suggest a new method based on the ideas of the break-point method. Results: We give a compilation of the showers from all four databases using both methods. Using the first (second) method, we separated 107 (133) showers, which are in at least one of the databases used. These relatively low numbers are a consequence of discarding any candidate shower with a poor statistical significance. Most of the separated showers were identified as meteor showers from the IAU MDC list of all showers. Many of them were identified as several of the showers in the list. This proves that many showers have been named multiple times with different names. Conclusions: At present, a prevailing share of existing annual showers can be found in the data and confirmed when we use a combination of results from large databases. However, to gain a complete list of showers, we need more-complete meteor databases than the most extensive databases currently are. We also still need a more sophisticated method to separate showers and evaluate their statistical significance. Tables A.1 and A.2 are also available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http

Search for nonstandard neutrino interactions with IceCube DeepCore

NASA Astrophysics Data System (ADS)

Aartsen, M. G.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Ahrens, M.; Al Samarai, I.; Altmann, D.; Andeen, K.; Anderson, T.; Ansseau, I.; Anton, G.; Argüelles, C.; Auffenberg, J.; Axani, S.; Bagherpour, H.; Bai, X.; Barron, J. P.; Barwick, S. W.; Baum, V.; Bay, R.; Beatty, J. J.; Becker Tjus, J.; Becker, K.-H.; BenZvi, S.; Berley, D.; Bernardini, E.; Besson, D. Z.; Binder, G.; Bindig, D.; Blaufuss, E.; Blot, S.; Bohm, C.; Börner, M.; Bos, F.; Bose, D.; Böser, S.; Botner, O.; Bourbeau, E.; Bourbeau, J.; Bradascio, F.; Braun, J.; Brayeur, L.; Brenzke, M.; Bretz, H.-P.; Bron, S.; Brostean-Kaiser, J.; Burgman, A.; Carver, T.; Casey, J.; Casier, M.; Cheung, E.; Chirkin, D.; Christov, A.; Clark, K.; Classen, L.; Coenders, S.; Collin, G. H.; Conrad, J. M.; Cowen, D. F.; Cross, R.; Day, M.; de André, J. P. A. M.; De Clercq, C.; DeLaunay, J. J.; Dembinski, H.; De Ridder, S.; Desiati, P.; de Vries, K. D.; de Wasseige, G.; de With, M.; DeYoung, T.; Díaz-Vélez, J. C.; di Lorenzo, V.; Dujmovic, H.; Dumm, J. P.; Dunkman, M.; Dvorak, E.; Eberhardt, B.; Ehrhardt, T.; Eichmann, B.; Eller, P.; Evenson, P. A.; Fahey, S.; Fazely, A. R.; Felde, J.; Filimonov, K.; Finley, C.; Flis, S.; Franckowiak, A.; Friedman, E.; Fuchs, T.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Ghorbani, K.; Giang, W.; Glauch, T.; Glüsenkamp, T.; Goldschmidt, A.; Gonzalez, J. G.; Grant, D.; Griffith, Z.; Haack, C.; Hallgren, A.; Halzen, F.; Hanson, K.; Hebecker, D.; Heereman, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hignight, J.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Hokanson-Fasig, B.; Hoshina, K.; Huang, F.; Huber, M.; Hultqvist, K.; Hünnefeld, M.; In, S.; Ishihara, A.; Jacobi, E.; Japaridze, G. S.; Jeong, M.; Jero, K.; Jones, B. J. P.; Kalaczynski, P.; Kang, W.; Kappes, A.; Karg, T.; Karle, A.; Katz, U.; Kauer, M.; Keivani, A.; Kelley, J. L.; Kheirandish, A.; Kim, J.; Kim, M.; Kintscher, T.; Kirby, C.; Kiryluk, J.; Kittler, T.; Klein, S. R.; Kohnen, G.; Koirala, R.; Kolanoski, H.; Köpke, L.; Kopper, C.; Kopper, S.; Koschinsky, J. P.; Koskinen, D. J.; Kowalski, M.; Krings, K.; Kroll, M.; Krückl, G.; Kunnen, J.; Kunwar, S.; Kurahashi, N.; Kuwabara, T.; Kyriacou, A.; Labare, M.; Lanfranchi, J. L.; Larson, M. J.; Lauber, F.; Lennarz, D.; Lesiak-Bzdak, M.; Leuermann, M.; Liu, Q. R.; Lu, L.; Lünemann, J.; Luszczak, W.; Madsen, J.; Maggi, G.; Mahn, K. B. M.; Mancina, S.; Maruyama, R.; Mase, K.; Maunu, R.; McNally, F.; Meagher, K.; Medici, M.; Meier, M.; Menne, T.; Merino, G.; Meures, T.; Miarecki, S.; Micallef, J.; Momenté, G.; Montaruli, T.; Moore, R. W.; Moulai, M.; Nahnhauer, R.; Nakarmi, P.; Naumann, U.; Neer, G.; Niederhausen, H.; Nowicki, S. C.; Nygren, D. R.; Obertacke Pollmann, A.; Olivas, A.; O'Murchadha, A.; Palczewski, T.; Pandya, H.; Pankova, D. V.; Peiffer, P.; Pepper, J. A.; Pérez de los Heros, C.; Pieloth, D.; Pinat, E.; Plum, M.; Price, P. B.; Przybylski, G. T.; Raab, C.; Rädel, L.; Rameez, M.; Rawlins, K.; Rea, I. C.; Reimann, R.; Relethford, B.; Relich, M.; Resconi, E.; Rhode, W.; Richman, M.; Robertson, S.; Rongen, M.; Rott, C.; Ruhe, T.; Ryckbosch, D.; Rysewyk, D.; Sälzer, T.; Sanchez Herrera, S. E.; Sandrock, A.; Sandroos, J.; Santander, M.; Sarkar, S.; Sarkar, S.; Satalecka, K.; Schlunder, P.; Schmidt, T.; Schneider, A.; Schoenen, S.; Schöneberg, S.; Schumacher, L.; Seckel, D.; Seunarine, S.; Soedingrekso, J.; Soldin, D.; Song, M.; Spiczak, G. M.; Spiering, C.; Stachurska, J.; Stamatikos, M.; Stanev, T.; Stasik, A.; Stettner, J.; Steuer, A.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Strotjohann, N. L.; Stuttard, T.; Sullivan, G. W.; Sutherland, M.; Taboada, I.; Tatar, J.; Tenholt, F.; Ter-Antonyan, S.; Terliuk, A.; Tešić, G.; Tilav, S.; Toale, P. A.; Tobin, M. N.; Toscano, S.; Tosi, D.; Tselengidou, M.; Tung, C. F.; Turcati, A.; Turley, C. F.; Ty, B.; Unger, E.; Usner, M.; Vandenbroucke, J.; Van Driessche, W.; van Eijndhoven, N.; Vanheule, S.; van Santen, J.; Vehring, M.; Vogel, E.; Vraeghe, M.; Walck, C.; Wallace, A.; Wallraff, M.; Wandler, F. D.; Wandkowsky, N.; Waza, A.; Weaver, C.; Weiss, M. J.; Wendt, C.; Werthebach, J.; Westerhoff, S.; Whelan, B. J.; Wiebe, K.; Wiebusch, C. H.; Wille, L.; Williams, D. R.; Wills, L.; Wolf, M.; Wood, J.; Wood, T. R.; Woolsey, E.; Woschnagg, K.; Xu, D. L.; Xu, X. W.; Xu, Y.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Yuan, T.; Zoll, M.; IceCube Collaboration

2018-04-01

As atmospheric neutrinos propagate through the Earth, vacuumlike oscillations are modified by Standard Model neutral- and charged-current interactions with electrons. Theories beyond the Standard Model introduce heavy, TeV-scale bosons that can produce nonstandard neutrino interactions. These additional interactions may modify the Standard Model matter effect producing a measurable deviation from the prediction for atmospheric neutrino oscillations. The result described in this paper constrains nonstandard interaction parameters, building upon a previous analysis of atmospheric muon-neutrino disappearance with three years of IceCube DeepCore data. The best fit for the muon to tau flavor changing term is ɛμ τ=-0.0005 , with a 90% C.L. allowed range of -0.0067 <ɛμ τ<0.0081 . This result is more restrictive than recent limits from other experiments for ɛμ τ. Furthermore, our result is complementary to a recent constraint on ɛμ τ using another publicly available IceCube high-energy event selection. Together, they constitute the world's best limits on nonstandard interactions in the μ -τ sector.

One-point fluctuation analysis of the high-energy neutrino sky

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feyereisen, Michael R.; Ando, Shin'ichiro; Tamborra, Irene, E-mail: m.r.feyereisen@uva.nl, E-mail: tamborra@nbi.ku.dk, E-mail: s.ando@uva.nl

2017-03-01

We perform the first one-point fluctuation analysis of the high-energy neutrino sky. This method reveals itself to be especially suited to contemporary neutrino data, as it allows to study the properties of the astrophysical components of the high-energy flux detected by the IceCube telescope, even with low statistics and in the absence of point source detection. Besides the veto-passing atmospheric foregrounds, we adopt a simple model of the high-energy neutrino background by assuming two main extra-galactic components: star-forming galaxies and blazars. By leveraging multi-wavelength data from Herschel and Fermi , we predict the spectral and anisotropic probability distributions for theirmore » expected neutrino counts in IceCube. We find that star-forming galaxies are likely to remain a diffuse background due to the poor angular resolution of IceCube, and we determine an upper limit on the number of shower events that can reasonably be associated to blazars. We also find that upper limits on the contribution of blazars to the measured flux are unfavourably affected by the skewness of the blazar flux distribution. One-point event clustering and likelihood analyses of the IceCube HESE data suggest that this method has the potential to dramatically improve over more conventional model-based analyses, especially for the next generation of neutrino telescopes.« less

Improved limit to the diffuse flux of ultrahigh energy neutrinos from the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Aab, A.; Abreu, P.; Aglietta, M.; Ahn, E. J.; Al Samarai, I.; Albuquerque, I. F. M.; Allekotte, I.; Allison, P.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Alves Batista, R.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Aramo, C.; Aranda, V. M.; Arqueros, F.; Arsene, N.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Awal, N.; Badescu, A. M.; Barber, K. B.; Bäuml, J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertaina, M. E.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blaess, S. G.; Blanco, A.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Borodai, N.; Brack, J.; Brancus, I.; Bridgeman, A.; Brogueira, P.; Brown, W. C.; Buchholz, P.; Bueno, A.; Buitink, S.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, B.; Caccianiga, L.; Candusso, M.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chavez, A. G.; Chiavassa, A.; Chinellato, J. A.; Chudoba, J.; Cilmo, M.; Clay, R. W.; Cocciolo, G.; Colalillo, R.; Coleman, A.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Cordier, A.; Coutu, S.; Covault, C. E.; Cronin, J.; Dallier, R.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Jong, S. J.; De Mauro, G.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; del Peral, L.; Deligny, O.; Dembinski, H.; Dhital, N.; Di Giulio, C.; Di Matteo, A.; Diaz, J. C.; Díaz Castro, M. L.; Diogo, F.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dorofeev, A.; Dorosti Hasankiadeh, Q.; Dova, M. T.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Falcke, H.; Fang, K.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Fernandes, M.; Fick, B.; Figueira, J. M.; Filevich, A.; Filipčič, A.; Fox, B. D.; Fratu, O.; Freire, M. M.; Fuchs, B.; Fujii, T.; García, B.; Garcia-Pinto, D.; Gate, F.; Gemmeke, H.; Gherghel-Lascu, A.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Głas, D.; Glaser, C.; Glass, H.; Golup, G.; Gómez Berisso, M.; Gómez Vitale, P. F.; González, N.; Gookin, B.; Gordon, J.; Gorgi, A.; Gorham, P.; Gouffon, P.; Griffith, N.; Grillo, A. F.; Grubb, T. D.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hampel, M. R.; Hansen, P.; Harari, D.; Harrison, T. A.; Hartmann, S.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Hollon, N.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huber, D.; Huege, T.; Insolia, A.; Isar, P. G.; Jandt, I.; Jansen, S.; Jarne, C.; Johnsen, J. A.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Kasper, P.; Katkov, I.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Krömer, O.; Kuempel, D.; Kunka, N.; LaHurd, D.; Latronico, L.; Lauer, R.; Lauscher, M.; Lautridou, P.; Le Coz, S.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; Lopes, L.; López, R.; López Casado, A.; Louedec, K.; Lu, L.; Lucero, A.; Malacari, M.; Maldera, S.; Mallamaci, M.; Maller, J.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Mariş, I. C.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Martínez Bravo, O.; Martraire, D.; Masías Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurel, D.; Maurizio, D.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Meissner, R.; Mello, V. B. B.; Melo, D.; Menshikov, A.; Messina, S.; Meyhandan, R.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Molina-Bueno, L.; Mollerach, S.; Montanet, F.; Morello, C.; Mostafá, M.; Moura, C. A.; Muller, M. A.; Müller, G.; Müller, S.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Neuser, J.; Nguyen, P. H.; Niculescu-Oglinzanu, M.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, L.; Ochilo, L.; Oikonomou, F.; Olinto, A.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Papenbreer, P.; Parente, G.; Parra, A.; Paul, T.; Pech, M.; PÈ©kala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Petermann, E.; Peters, C.; Petrera, S.; Petrov, Y.; Phuntsok, J.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porcelli, A.; Porowski, C.; Prado, R. R.; Privitera, P.; Prouza, M.; Purrello, V.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rizi, V.; Rodrigues de Carvalho, W.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rodríguez-Frías, M. D.; Rogozin, D.; Rosado, J.; Roth, M.; Roulet, E.; Rovero, A. C.; Saffi, S. J.; Saftoiu, A.; Salamida, F.; Salazar, H.; Saleh, A.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Sanchez-Lucas, P.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarmento, R.; Sato, R.; Scarso, C.; Schauer, M.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, D.; Scholten, O.; Schoorlemmer, H.; Schovánek, P.; Schröder, F. G.; Schulz, A.; Schulz, J.; Schumacher, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Squartini, R.; Srivastava, Y. N.; Stanca, D.; Stanič, S.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Taborda, O. A.; Tapia, A.; Tepe, A.; Theodoro, V. M.; Tiffenberg, J.; Timmermans, C.; Todero Peixoto, C. J.; Toma, G.; Tomankova, L.; Tomé, B.; Tonachini, A.; Torralba Elipe, G.; Torres Machado, D.; Travnicek, P.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van Bodegom, P.; van den Berg, A. M.; van Velzen, S.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vasquez, R.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Vlcek, B.; Vorobiov, S.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Werner, F.; Widom, A.; Wiencke, L.; Wilczyński, H.; Winchen, T.; Wittkowski, D.; Wundheiler, B.; Wykes, S.; Yang, L.; Yapici, T.; Yushkov, A.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zepeda, A.; Zhu, Y.; Zimmermann, B.; Ziolkowski, M.; Zuccarello, F.; Pierre Auger Collaboration

2015-05-01

Neutrinos in the cosmic ray flux with energies near 1 EeV and above are detectable with the Surface Detector array (SD) of the Pierre Auger Observatory. We report here on searches through Auger data from 1 January 2004 until 20 June 2013. No neutrino candidates were found, yielding a limit to the diffuse flux of ultrahigh energy neutrinos that challenges the Waxman-Bahcall bound predictions. Neutrino identification is attempted using the broad time structure of the signals expected in the SD stations, and is efficiently done for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for "Earth-skimming" neutrino interactions in the case of tau neutrinos. In this paper the searches for downward-going neutrinos in the zenith angle bins 60°-75° and 75°-90° as well as for upward-going neutrinos, are combined to give a single limit. The 90% C.L. single-flavor limit to the diffuse flux of ultrahigh energy neutrinos with an E-2 spectrum in the energy range 1.0 ×1 017 eV - 2.5 ×1 019 eV is Eν2d Nν/d Eν<6.4 ×10-9 GeV cm-2 s-1 sr-1 .

Meteor Shower Forecasting for Spacecraft Operations

NASA Technical Reports Server (NTRS)

Moorhead, Althea V.; Cooke, William J.; Campbell-Brown, Margaret D.

2017-01-01

Although sporadic meteoroids generally pose a much greater hazard to spacecraft than shower meteoroids, meteor showers can significantly increase the risk of damage over short time periods. Because showers are brief, it is sometimes possible to mitigate the risk operationally, which requires accurate predictions of shower activity. NASA's Meteoroid Environment Office (MEO) generates an annual meteor shower forecast that describes the variations in the near-Earth meteoroid flux produced by meteor showers, and presents the shower flux both in absolute terms and relative to the sporadic flux. The shower forecast incorporates model predictions of annual variations in shower activity and quotes fluxes to several limiting particle kinetic energies. In this work, we describe our forecasting methods and present recent improvements to the temporal profiles based on flux measurements from the Canadian Meteor Orbit Radar (CMOR).

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice

PubMed Central

Garringer, Holly J.; Murrell, Jill; Sammeta, Neeraja; Gnezda, Anita; Ghetti, Bernardino; Vidal, Ruben

2013-01-01

Familial Danish dementia (FDD) is an autosomal dominant neurodegenerative disease caused by a 10-nucleotide duplication-insertion in the BRI2 gene. FDD is clinically characterized by loss of vision, hearing impairment, cerebellar ataxia and dementia. The main neuropathologic findings in FDD are the deposition of Danish amyloid (ADan) and the presence of neurofibrillary tangles (NFTs). Here we investigated tau accumulation and truncation in double transgenic (Tg-FDD-Tau) mice generated by crossing transgenic mice expressing human Danish mutant BRI2 (Tg-FDD) with mice expressing human 4-repeat mutant Tau-P301S (Tg-Tau). Compared to Tg-Tau mice, we observed a significant enhancement of tau deposition in Tg-FDD-Tau mice. In addition, a significant increase in tau cleaved at aspartic acid (Asp) 421 was observed in Tg-FDD-Tau mice. Tg-FDD-Tau mice also showed a significant decrease in synaptophysin levels, occurring before widespread deposition of fibrillar ADan and tau can be observed. Thus, the presence of soluble ADan/mutant BRI2 can lead to significant changes in tau metabolism and synaptic dysfunction. Our data provide new in vivo insights into the pathogenesis of FDD and the pathogenic pathway(s) by which amyloidogenic peptides, regardless of their primary amino acid sequence, can cause neurodegeneration. PMID:23418567

Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.

PubMed

Garringer, Holly J; Murrell, Jill; Sammeta, Neeraja; Gnezda, Anita; Ghetti, Bernardino; Vidal, Ruben

2013-01-01

Familial Danish dementia (FDD) is an autosomal dominant neurodegenerative disease caused by a 10-nucleotide duplication-insertion in the BRI(2) gene. FDD is clinically characterized by loss of vision, hearing impairment, cerebellar ataxia and dementia. The main neuropathologic findings in FDD are the deposition of Danish amyloid (ADan) and the presence of neurofibrillary tangles (NFTs). Here we investigated tau accumulation and truncation in double transgenic (Tg-FDD-Tau) mice generated by crossing transgenic mice expressing human Danish mutant BRI(2) (Tg-FDD) with mice expressing human 4-repeat mutant Tau-P301S (Tg-Tau). Compared to Tg-Tau mice, we observed a significant enhancement of tau deposition in Tg-FDD-Tau mice. In addition, a significant increase in tau cleaved at aspartic acid (Asp) 421 was observed in Tg-FDD-Tau mice. Tg-FDD-Tau mice also showed a significant decrease in synaptophysin levels, occurring before widespread deposition of fibrillar ADan and tau can be observed. Thus, the presence of soluble ADan/mutant BRI(2) can lead to significant changes in tau metabolism and synaptic dysfunction. Our data provide new in vivo insights into the pathogenesis of FDD and the pathogenic pathway(s) by which amyloidogenic peptides, regardless of their primary amino acid sequence, can cause neurodegeneration.

Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation

PubMed Central

Cohen, Todd J.; Constance, Brian H.; Hwang, Andrew W.; James, Michael; Yuan, Chao-Xing

2016-01-01

Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer’s disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for normal tau function and its pathological aggregation. Here, we demonstrate that tau isoforms have different propensities to undergo lysine acetylation, with auto-acetylation occurring more prominently within the lysine-rich microtubule-binding repeats. Unexpectedly, we identified a unique intrinsic property of tau in which auto-acetylation induces proteolytic tau cleavage, thereby generating distinct N- and C-terminal tau fragments. Supporting a catalytic reaction-based mechanism, mapping and mutagenesis studies showed that tau cysteines, which are required for acetyl group transfer, are also essential for auto-proteolytic tau processing. Further mass spectrometry analysis identified the C-terminal 2nd and 4th microtubule binding repeats as potential sites of auto-cleavage. The identification of acetylation-mediated auto-proteolysis provides a new biochemical mechanism for tau self-regulation and warrants further investigation into whether auto-catalytic functions of tau are implicated in AD and other tauopathies. PMID:27383765

Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation.

PubMed

Cohen, Todd J; Constance, Brian H; Hwang, Andrew W; James, Michael; Yuan, Chao-Xing

2016-01-01

Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer's disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for normal tau function and its pathological aggregation. Here, we demonstrate that tau isoforms have different propensities to undergo lysine acetylation, with auto-acetylation occurring more prominently within the lysine-rich microtubule-binding repeats. Unexpectedly, we identified a unique intrinsic property of tau in which auto-acetylation induces proteolytic tau cleavage, thereby generating distinct N- and C-terminal tau fragments. Supporting a catalytic reaction-based mechanism, mapping and mutagenesis studies showed that tau cysteines, which are required for acetyl group transfer, are also essential for auto-proteolytic tau processing. Further mass spectrometry analysis identified the C-terminal 2nd and 4th microtubule binding repeats as potential sites of auto-cleavage. The identification of acetylation-mediated auto-proteolysis provides a new biochemical mechanism for tau self-regulation and warrants further investigation into whether auto-catalytic functions of tau are implicated in AD and other tauopathies.

Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro.

PubMed

Paranjape, Smita R; Riley, Andrew P; Somoza, Amber D; Oakley, C Elizabeth; Wang, Clay C C; Prisinzano, Thomas E; Oakley, Berl R; Gamblin, T Chris

2015-05-20

The aggregation of the microtubule-associated protein tau is a seminal event in many neurodegenerative diseases, including Alzheimer's disease. The inhibition or reversal of tau aggregation is therefore a potential therapeutic strategy for these diseases. Fungal natural products have proven to be a rich source of useful compounds having wide varieties of biological activities. We have previously screened Aspergillus nidulans secondary metabolites for their ability to inhibit tau aggregation in vitro using an arachidonic acid polymerization protocol. One aggregation inhibitor identified was asperbenzaldehyde, an intermediate in azaphilone biosynthesis. We therefore tested 11 azaphilone derivatives to determine their tau assembly inhibition properties in vitro. All compounds tested inhibited tau filament assembly to some extent, and four of the 11 compounds had the advantageous property of disassembling preformed tau aggregates in a dose-dependent fashion. The addition of these compounds to the tau aggregates reduced both the total length and number of tau polymers. The most potent compounds were tested in in vitro reactions to determine whether they interfere with tau's normal function of stabilizing microtubules (MTs). We found that they did not completely inhibit MT assembly in the presence of tau. These derivatives are very promising lead compounds for tau aggregation inhibitors and, more excitingly, for compounds that can disassemble pre-existing tau filaments. They also represent a new class of anti-tau aggregation compounds with a novel structural scaffold.

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau.

PubMed

Lasagna-Reeves, Cristian A; Castillo-Carranza, Diana L; Sengupta, Urmi; Guerrero-Munoz, Marcos J; Kiritoshi, Takaki; Neugebauer, Volker; Jackson, George R; Kayed, Rakez

2012-01-01

Intracerebral injection of brain extracts containing amyloid or tau aggregates in transgenic animals can induce cerebral amyloidosis and tau pathology. We extracted pure populations of tau oligomers directly from the cerebral cortex of Alzheimer disease (AD) brain. These oligomers are potent inhibitors of long term potentiation (LTP) in hippocampal brain slices and disrupt memory in wild type mice. We observed for the first time that these authentic brain-derived tau oligomers propagate abnormal tau conformation of endogenous murine tau after prolonged incubation. The conformation and hydrophobicity of tau oligomers play a critical role in the initiation and spread of tau pathology in the naïve host in a manner reminiscent of sporadic AD.

Dark matter searches for monoenergetic neutrinos arising from stopped meson decay in the Sun

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rott, Carsten; In, Seongjin; Kumar, Jason

Dark matter can be gravitationally captured by the Sun after scattering off solar nuclei. Annihilations of the dark matter trapped and accumulated in the centre of the Sun could result in one of the most detectable and recognizable signals for dark matter. Searches for high-energy neutrinos produced in the decay of annihilation products have yielded extremely competitive constraints on the spin-dependent scattering cross sections of dark matter with nuclei. Recently, the low energy neutrino signal arising from dark-matter annihilation to quarks which then hadronize and shower has been suggested as a competitive and complementary search strategy. These high-multiplicity hadronic showersmore » give rise to a large amount of pions which will come to rest in the Sun and decay, leading to a unique sub-GeV neutrino signal. We here improve on previous works by considering the monoenergetic neutrino signal arising from both pion and kaon decay. We consider searches at liquid scintillation, liquid argon, and water Cherenkov detectors and find very competitive sensitivities for few-GeV dark matter masses.« less

What can we learn on supernova neutrino spectra with water Cherenkov detectors?

NASA Astrophysics Data System (ADS)

Gallo Rosso, Andrea; Vissani, Francesco; Volpe, Maria Cristina

2018-04-01

We investigate the precision with which the supernova neutrino spectra can be reconstructed in water Cherenkov detectors, in particular the large scale Hyper-Kamiokande and Super-Kamiokande. To this aim, we consider quasi-thermal neutrino spectra modified by the Mikheev-Smirnov-Wolfenstein effect for the case of normal ordering. We perform three 9 degrees of freedom likelihood analyses including first inverse-beta decay only, then the combination of inverse beta decay and elastic scattering on electrons and finally a third analysis that also includes neutral scattering neutrino-oxygen events. A tenth parameter is added in the analyses to account for the theoretical uncertainty on the neutral current neutrino-oxygen cross section. By assuming a 100% efficiency in Hyper-Kamiokande, we show that one can reconstruct the electron antineutrino average energy and pinching parameter with an accuracy of ~2% and ~7% percent respectively, while the antineutrino integrated luminosity can be pinned down at ~3% percent level. As for the muon and tau neutrinos, the average energy and the integrated luminosity can be measured with ~7% precision. These results represent a significant improvement with respect Super-Kamiokande, particularly for the pinching parameter defining the electron antineutrino spectra. As for electron neutrinos, the determination of the emission parameters requires the addition of supplementary detection channels.

Bounds on the Coupling of the Majoron to Light Neutrinos from Supernova Cooling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farzan, Yasaman

2002-12-02

We explore the role of Majoron (J) emission in the supernova cooling process, as a source of upper bound on the neutrino-Majoron coupling. We show that the strongest upper bound on the coupling to {nu}{sub 3} comes from the {nu}{sub e}{nu}{sub e} {yields} J process in the core of a supernova. We also find bounds on diagonal couplings of the Majoron to {nu}{sub {mu}({tau})}{nu}{sub {mu}({tau})} and on off-diagonal {nu}{sub e}{nu}{sub {mu}({tau})} couplings in various regions of the parameter space. We discuss the evaluation of cross-section for four-particle interactions ({nu}{nu} {yields} JJ and {nu}J {yields} {nu}J). We show that these aremore » typically dominated by three-particle sub-processes and do not give new independent constraints.« less

Improved limit to the diffuse flux of ultrahigh energy neutrinos from the Pierre Auger Observatory

DOE PAGES

Aab, Alexander

2015-05-26

Neutrinos in the cosmic ray flux with energies near 1 EeV and above are detectable with the Surface Detector array (SD) of the Pierre Auger Observatory. We report here on searches through Auger data from 1 January 2004 until 20 June 2013. No neutrino candidates were found, yielding a limit to the diffuse flux of ultrahigh energy neutrinos that challenges the Waxman-Bahcall bound predictions. Neutrino identification is attempted using the broad time structure of the signals expected in the SD stations, and is efficiently done for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as wellmore » as for “Earth-skimming” neutrino interactions in the case of tau neutrinos. In this paper the searches for downward-going neutrinos in the zenith angle bins 60°–75° and 75°–90° as well as for upward-going neutrinos, are combined to give a single limit. In addition, the 90% C.L. single-flavor limit to the diffuse flux of ultrahigh energy neutrinos with an E –2 spectrum in the energy range 1.0 × 10 17 eV – 2.5 × 10 19 eV is E 2 νdN ν/dE ν < 6.4 × 10 –9 GeV cm –2 s –1 sr –1.« less

Discovering intermediate mass sterile neutrinos through τ-→π-μ-e+ν (or ν ¯ ) decay

NASA Astrophysics Data System (ADS)

Kim, C. S.; López Castro, G.; Sahoo, Dibyakrupa

2017-10-01

Distinguishing the Dirac and Majorana nature of neutrinos remains one of the most important tasks in neutrino physics. By assuming that the τ-→π-μ-e+ν (or ν ¯ ) decay is resonantly enhanced by the exchange of an intermediate mass sterile neutrino N , we show that the energy spectrum of emitted pions and muons can be used to easily distinguish between the Dirac and Majorana nature of N . This method takes advantage of the fact that the flavor of light neutrinos is not identified in the tau decay under consideration. We find that it is particularly advantageous, because of no competing background events, to search for N in the mass range me+mμ≤mN≤mμ+mπ, where mX denotes the mass of particle X ∈{e ,μ ,π ,N }.

Long baseline neutrino oscillation experiment at the AGS

NASA Astrophysics Data System (ADS)

Beavis, D.; Carroll, A.; Chiang, I.

1995-04-01

The authors present a design for a multidetector long baseline neutrino oscillation experiment at the BNL AGS. It has been approved by the BNL-HENP-PAC as AGS Experiment 889. The experiment will search for oscillations in the nu(sub mu) disappearance channel and the nu(sub mu) reversible reaction nu(sub e) appearance channel by means of four identical neutrino detectors located 1, 3, 24, and 68 km from the AGS neutrino source. Observed depletion of the nu(sub mu) flux (via quasi-elastic muon neutrino events, nu(sub mu)n yields mu(-)p) in the far detectors not attended by an observed proportional increase of the nu(sub e) flux (via quasi-elastic electron neutrino events, nu(sub e)n yields e(-)p) in those detectors will be prima facie evidence for the oscillation channel nu(sub mu) reversible reaction nu(sub tau). The experiment is directed toward exploration of the region of the neutrino oscillation parameters Delta m(exp 2) and sin(exp 2) 2 theta, suggested by the Kamiokande and IMB deep underground detectors but it will also explore a region more than two orders of magnitude larger than that of previous accelerator experiments. The experiment will run in a mode new to BNL. It will receive the fast extracted proton beam on the neutrino target approximately 20 hours per day when the AGS is not filling RHIC. A key aspect of the experimental design involves placing the detectors 1.5 degrees off the center line of the neutrino beam, which has the important advantage that the central value of the neutrino energy (approximately 1 GeV) and the beam spectral shape are, to a good approximation, the same in all four detectors. The proposed detectors are massive, imaging, water Cherenkov detectors similar in large part to the Kamiokande and IMB detectors. The design has profited from their decade-long experience, and from the detector designs of the forthcoming SNO and SuperKamiokande detectors.

EUSO-SPB2: second generation Extreme Universe Space Observatory (EUSO) on board a Super-Pressure Balloon (SPB), The University of Alabama in Huntsville, Co-I PROPOSAL

NASA Astrophysics Data System (ADS)

Reardon, Patrick

This is the Co-Investigator Proposal for EUSO-SPB2, second generation Extreme Universe Space Observatory on a Super-Pressure Balloon, being led by PI Angela V. Olinto at the University of Chicago. We propose to design, build, deploy, and publish the scientific results of a second generation of the Extreme Universe Space Observatory (EUSO), to be flown aboard a Super-Pressure Balloon (SBP). EUSO-SPB2 will monitor the night sky of the Southern hemisphere to study cosmic rays of very high to ultrahigh energies and pioneer the search for cosmogenic tau neutrinos from space. EUSO-SPB2 will be the first instrument to observe Cherenkov light from extensive air-showers high in the atmosphere. EUSOSPB2 will observe a large sample of cosmic rays from 0.1 to 1 EeV with the Cherenkov technique and will discriminate among the Cherenkov profiles of primary protons, heavy nuclei, and photons. It will also characterize the background for upward going showers initiated by the decay of tau leptons, which are expected to be produced by Earthskimming tau neutrinos. A coincidence veto will be developed for EUSO-SPB2 so it can characterize the background for Cherenkov signals from the neutrino produced tau leptons. EUSO-SPB2 will also use fluorescence observations to measure, for the first time, the evolution of nearly horizontal high altitude extensive air showers, which develop at the nearly constant low-density atmosphere. Such measurements will provide a unique channel to probe hadronic interaction models at ultrahigh energies, and may elucidate the reason why ultrahigh-energy cosmic ray (UHECR) showers observed by ground-based detectors contain more muons than expected from hadronic interaction models. EUSO-SPB2 is a pathfinder for the more ambitious space-based measurements by the Probe Of Extreme Multi-Messenger Astrophysics (POEMMA), currently proposed for a NASA design study. POEMMA will combine the well-developed Orbiting Widefield Light-collectors (OWL) concept with the

Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro.

PubMed

Rane, Jitendra Subhash; Bhaumik, Prasenjit; Panda, Dulal

2017-01-01

The pathological aggregation of tau is a common feature of most of the neuronal disorders including frontotemporal dementia, Parkinson's disease, and Alzheimer's disease. The inhibition of tau aggregation is considered to be one of the important strategies for treating these neurodegenerative diseases. Curcumin, a natural polyphenolic molecule, has been reported to have neuroprotective ability. In this work, curcumin was found to bind to adult tau and fetal tau with a dissociation constant of 3.3±0.4 and 8±1 μM, respectively. Molecular docking studies indicated a putative binding site of curcumin in the microtubule-binding region of tau. Using several complementary techniques, including dynamic light scattering, thioflavin S fluorescence, 90° light scattering, electron microscopy, and atomic force microscopy, curcumin was found to inhibit the aggregation of tau. The dynamic light scattering analysis and atomic force microscopic images revealed that curcumin inhibits the oligomerization of tau. Curcumin also disintegrated preformed tau oligomers. Using Far-UV circular dichroism, curcumin was found to inhibit the β-sheets formation in tau indicating that curcumin inhibits an initial step of tau aggregation. In addition, curcumin inhibited tau fibril formation. Furthermore, the effect of curcumin on the preformed tau filaments was analyzed by atomic force microscopy, transmission electron microscopy, and 90° light scattering. Curcumin treatment disintegrated preformed tau filaments. The results indicated that curcumin inhibited the oligomerization of tau and could disaggregate tau filaments.

Probing possible decoherence effects in atmospheric neutrino oscillations.

PubMed

Lisi, E; Marrone, A; Montanino, D

2000-08-07

It is shown that the results of the Super-Kamiokande atmospheric neutrino experiment, interpreted in terms of nu(mu)<-->nu(tau) flavor transitions, can probe possible decoherence effects induced by new physics (e.g., by quantum gravity) with high sensitivity, supplementing current laboratory tests based on kaon oscillations and on neutron interferometry. By varying the (unknown) energy dependence of such effects, one can either obtain strong limits on their amplitude or use them to find an unconventional solution to the atmospheric nu anomaly based solely on decoherence.

CAMS confirmation of previously reported meteor showers

NASA Astrophysics Data System (ADS)

Jenniskens, P.; Nénon, Q.; Gural, P. S.; Albers, J.; Haberman, B.; Johnson, B.; Holman, D.; Morales, R.; Grigsby, B. J.; Samuels, D.; Johannink, C.

2016-03-01

Leading up to the 2015 IAU General Assembly, the International Astronomical Union's Working List of Meteor Showers included 486 unconfirmed showers, showers that are not certain to exist. If confirmed, each shower would provide a record of past comet or asteroid activity. Now, we report that 41 of these are detected in the Cameras for Allsky Meteor Surveillance (CAMS) video-based meteor shower survey. They manifest as meteoroids arriving at Earth from a similar direction and orbit, after removing the daily radiant drift due to Earth's motion around the Sun. These showers do exist and, therefore, can be moved to the IAU List of Established Meteor Showers. This adds to 31 previously confirmed showers from CAMS data. For each shower, finding charts are presented based on 230,000 meteors observed up to March of 2015, calculated by re-projecting the drift-corrected Sun-centered ecliptic coordinates into more familiar equatorial coordinates. Showers that are not detected, but should have, and duplicate showers that project to the same Sun-centered ecliptic coordinates, are recommended for removal from the Working List.

Search for neutrinos from dark matter self-annihilations in the center of the Milky Way with 3 years of IceCube/DeepCore

NASA Astrophysics Data System (ADS)

Aartsen, M. G.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Ahrens, M.; Al Samarai, I.; Altmann, D.; Andeen, K.; Anderson, T.; Ansseau, I.; Anton, G.; Argüelles, C.; Auffenberg, J.; Axani, S.; Bagherpour, H.; Bai, X.; Barron, J. P.; Barwick, S. W.; Baum, V.; Bay, R.; Beatty, J. J.; Tjus, J. Becker; Becker, K.-H.; BenZvi, S.; Berley, D.; Bernardini, E.; Besson, D. Z.; Binder, G.; Bindig, D.; Blaufuss, E.; Blot, S.; Bohm, C.; Börner, M.; Bos, F.; Bose, D.; Böser, S.; Botner, O.; Bourbeau, J.; Bradascio, F.; Braun, J.; Brayeur, L.; Brenzke, M.; Bretz, H.-P.; Bron, S.; Burgman, A.; Carver, T.; Casey, J.; Casier, M.; Cheung, E.; Chirkin, D.; Christov, A.; Clark, K.; Classen, L.; Coenders, S.; Collin, G. H.; Conrad, J. M.; Cowen, D. F.; Cross, R.; Day, M.; de André, J. P. A. M.; De Clercq, C.; DeLaunay, J. J.; Dembinski, H.; De Ridder, S.; Desiati, P.; de Vries, K. D.; de Wasseige, G.; de With, M.; DeYoung, T.; Díaz-Vélez, J. C.; di Lorenzo, V.; Dujmovic, H.; Dumm, J. P.; Dunkman, M.; Eberhardt, B.; Ehrhardt, T.; Eichmann, B.; Eller, P.; Evenson, P. A.; Fahey, S.; Fazely, A. R.; Felde, J.; Filimonov, K.; Finley, C.; Flis, S.; Franckowiak, A.; Friedman, E.; Fuchs, T.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Ghorbani, K.; Giang, W.; Glauch, T.; Glüsenkamp, T.; Goldschmidt, A.; Gonzalez, J. G.; Grant, D.; Griffith, Z.; Haack, C.; Hallgren, A.; Halzen, F.; Hanson, K.; Hebecker, D.; Heereman, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hignight, J.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Hokanson-Fasig, B.; Hoshina, K.; Huang, F.; Huber, M.; Hultqvist, K.; In, S.; Ishihara, A.; Jacobi, E.; Japaridze, G. S.; Jeong, M.; Jero, K.; Jones, B. J. P.; Kalacynski, P.; Kang, W.; Kappes, A.; Karg, T.; Karle, A.; Katz, U.; Kauer, M.; Keivani, A.; Kelley, J. L.; Kheirandish, A.; Kim, J.; Kim, M.; Kintscher, T.; Kiryluk, J.; Kittler, T.; Klein, S. R.; Kohnen, G.; Koirala, R.; Kolanoski, H.; Köpke, L.; Kopper, C.; Kopper, S.; Koschinsky, J. P.; Koskinen, D. J.; Kowalski, M.; Krings, K.; Kroll, M.; Krückl, G.; Kunnen, J.; Kunwar, S.; Kurahashi, N.; Kuwabara, T.; Kyriacou, A.; Labare, M.; Lanfranchi, J. L.; Larson, M. J.; Lauber, F.; Lennarz, D.; Lesiak-Bzdak, M.; Leuermann, M.; Liu, Q. R.; Lu, L.; Lünemann, J.; Luszczak, W.; Madsen, J.; Maggi, G.; Mahn, K. B. M.; Mancina, S.; Maruyama, R.; Mase, K.; Maunu, R.; McNally, F.; Meagher, K.; Medici, M.; Meier, M.; Menne, T.; Merino, G.; Meures, T.; Miarecki, S.; Micallef, J.; Momenté, G.; Montaruli, T.; Moore, R. W.; Moulai, M.; Nahnhauer, R.; Nakarmi, P.; Naumann, U.; Neer, G.; Niederhausen, H.; Nowicki, S. C.; Nygren, D. R.; Pollmann, A. Obertacke; Olivas, A.; O'Murchadha, A.; Palczewski, T.; Pandya, H.; Pankova, D. V.; Peiffer, P.; Pepper, J. A.; de los Heros, C. Pérez; Pieloth, D.; Pinat, E.; Plum, M.; Price, P. B.; Przybylski, G. T.; Raab, C.; Rädel, L.; Rameez, M.; Rawlins, K.; Reimann, R.; Relethford, B.; Relich, M.; Resconi, E.; Rhode, W.; Richman, M.; Riedel, B.; Robertson, S.; Rongen, M.; Rott, C.; Ruhe, T.; Ryckbosch, D.; Rysewyk, D.; Sälzer, T.; Sanchez Herrera, S. E.; Sandrock, A.; Sandroos, J.; Sarkar, S.; Sarkar, S.; Satalecka, K.; Schlunder, P.; Schmidt, T.; Schneider, A.; Schoenen, S.; Schöneberg, S.; Schumacher, L.; Seckel, D.; Seunarine, S.; Soldin, D.; Song, M.; Spiczak, G. M.; Spiering, C.; Stachurska, J.; Stanev, T.; Stasik, A.; Stettner, J.; Steuer, A.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Strotjohann, N. L.; Sullivan, G. W.; Sutherland, M.; Taboada, I.; Tatar, J.; Tenholt, F.; Ter-Antonyan, S.; Terliuk, A.; Tešić, G.; Tilav, S.; Toale, P. A.; Tobin, M. N.; Toscano, S.; Tosi, D.; Tselengidou, M.; Tung, C. F.; Turcati, A.; Turley, C. F.; Ty, B.; Unger, E.; Usner, M.; Vandenbroucke, J.; Driessche, W. Van; Eijndhoven, N. van; Vanheule, S.; Santen, J. van; Vehring, M.; Vogel, E.; Vraeghe, M.; Walck, C.; Wallace, A.; Wallraff, M.; Wandler, F. D.; Wandkowsky, N.; Waza, A.; Weaver, C.; Weiss, M. J.; Wendt, C.; Westerhoff, S.; Whelan, B. J.; Wickmann, S.; Wiebe, K.; Wiebusch, C. H.; Wille, L.; Williams, D. R.; Wills, L.; Wolf, M.; Wood, J.; Wood, T. R.; Woolsey, E.; Woschnagg, K.; Xu, D. L.; Xu, X. W.; Xu, Y.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Yuan, T.; Zoll, M.

2017-09-01

We present a search for a neutrino signal from dark matter self-annihilations in the Milky Way using the IceCube Neutrino Observatory (IceCube). In 1005 days of data we found no significant excess of neutrinos over the background of neutrinos produced in atmospheric air showers from cosmic ray interactions. We derive upper limits on the velocity averaged product of the dark matter self-annihilation cross section and the relative velocity of the dark matter particles < σ _{ {A}}v> . Upper limits are set for dark matter particle candidate masses ranging from 10 GeV up to 1 TeV while considering annihilation through multiple channels. This work sets the most stringent limit on a neutrino signal from dark matter with mass between 10 and 100 GeV, with a limit of 1.18\\cdot 10^{-23} { cm}^3 {s}^{-1} for 100 GeV dark matter particles self-annihilating via τ ^+τ ^- to neutrinos (assuming the Navarro-Frenk-White dark matter halo profile).

Studies of non-standard effects in atmospheric neutrino oscillations of Super-Kamiokande

NASA Astrophysics Data System (ADS)

Wang, Wei

that the oscillation between muon neutrinos and tau neutrinos is the best model explaining SK atmospheric neutrino data among the models we test. In most cases, limits on new physics established in this study using SK atmospheric neutrino data are the best currently available.

Rethinking antiparticles. Hermann Weyl's contribution to neutrino physics

NASA Astrophysics Data System (ADS)

De Bianchi, Silvia

2018-02-01

This paper focuses on Hermann Weyl's two-component theory and frames it within the early development of different theories of spinors and the history of the discovery of parity violation in weak interactions. In order to show the implications of Weyl's theory, the paper discusses the case study of Ettore Majorana's symmetric theory of electron and positron (1937), as well as its role in inspiring Case's formulation of parity violation for massive neutrinos in 1957. In doing so, this paper clarifies the relevance of Weyl's and Majorana's theories for the foundations of neutrino physics and emphasizes which conceptual aspects of Weyl's approach led to Lee's and Yang's works on neutrino physics and to the solution of the theta-tau puzzle in 1957. This contribution thus sheds a light on the alleged "re-discovery" of Weyl's and Majorana's theories in 1957, by showing that this did not happen all of a sudden. On the contrary, the scientific community was well versed in applying these theories in the 1950s on the ground of previous studies that involved important actors in both Europe and United States.

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

PubMed Central

Yanamandra, Kiran; Patel, Tirth K.; Jiang, Hong; Schindler, Suzanne; Ulrich, Jason D.; Boxer, Adam L.; Miller, Bruce L.; Kerwin, Diana R.; Gallardo, Gilbert; Stewart, Floy; Finn, Mary Beth; Cairns, Nigel J.; Verghese, Philip B.; Fogelman, Ilana; West, Tim; Braunstein, Joel; Robinson, Grace; Keyser, Jennifer; Roh, Joseph; Knapik, Stephanie S.; Hu, Yan; Holtzman, David M.

2017-01-01

Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A promising treatment being explored for tauopathies is passive immunization with anti-tau antibodies. We previously found that administration of an anti-tau antibody to human tau transgenic mice increased the concentration of plasma tau. We further explored the effects of administering an anti-tau antibody on plasma tau. After peripheral administration of an anti-tau antibody to human patients with tauopathy and to mice expressing human tau in the central nervous system, there was a dose-dependent increase in plasma tau. In mouse plasma, we found that tau had a short half-life of 8 min that increased to more than 3 hours after administration of anti-tau antibody. As tau transgenic mice accumulated insoluble tau in the brain, brain soluble and interstitial fluid tau decreased. Administration of anti-tau antibody to tau transgenic mice that had decreased brain soluble tau and interstitial fluid tau resulted in an increase in plasma tau, but this increase was less than that observed in tau transgenic mice without these brain changes. Tau transgenic mice subjected to acute neuronal injury using 3-nitropropionic acid showed increased interstitial fluid tau and plasma tau. These data suggest that peripheral administration of an anti-tau antibody results in increased plasma tau, which correlates with the concentration of extracellular and soluble tau in the brain. PMID:28424326

Analytic calculation of radio emission from parametrized extensive air showers: A tool to extract shower parameters

NASA Astrophysics Data System (ADS)

Scholten, O.; Trinh, T. N. G.; de Vries, K. D.; Hare, B. M.

2018-01-01

The radio intensity and polarization footprint of a cosmic-ray induced extensive air shower is determined by the time-dependent structure of the current distribution residing in the plasma cloud at the shower front. In turn, the time dependence of the integrated charge-current distribution in the plasma cloud, the longitudinal shower structure, is determined by interesting physics which one would like to extract, such as the location and multiplicity of the primary cosmic-ray collision or the values of electric fields in the atmosphere during thunderstorms. To extract the structure of a shower from its footprint requires solving a complicated inverse problem. For this purpose we have developed a code that semianalytically calculates the radio footprint of an extensive air shower given an arbitrary longitudinal structure. This code can be used in an optimization procedure to extract the optimal longitudinal shower structure given a radio footprint. On the basis of air-shower universality we propose a simple parametrization of the structure of the plasma cloud. This parametrization is based on the results of Monte Carlo shower simulations. Deriving the parametrization also teaches which aspects of the plasma cloud are important for understanding the features seen in the radio-emission footprint. The calculated radio footprints are compared with microscopic CoREAS simulations.

New meteor showers – yes or not?

NASA Astrophysics Data System (ADS)

Koukal, Jakub

2018-01-01

The development of meteor astronomy associated with the development of CCD technology is reflected in a huge increase in databases of meteor orbits. It has never been possible before in the history of meteor astronomy to examine properties of meteors or meteor showers. Existing methods for detecting new meteor showers seem to be inadequate in these circumstances. The spontaneous discovery of new meteor showers leads to ambiguous specifications of new meteor showers. There is a duplication of already discovered meteor showers and a division of existing meteor showers based on their own criteria. The analysis in this article considers some new meteor showers in the IAU MDC database.

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers

PubMed Central

Rubenstein, Richard; Chang, Binggong; Yue, John K.; Chiu, Allen; Winkler, Ethan A.; Puccio, Ava M.; Diaz-Arrastia, Ramon; Yuh, Esther L.; Mukherjee, Pratik; Valadka, Alex B.; Gordon, Wayne A.; Okonkwo, David O.; Davies, Peter; Agarwal, Sanjeev; Lin, Fan; Sarkis, George; Yadikar, Hamad; Yang, Zhihui; Manley, Geoffrey T.; Wang, Kevin K. W.

2017-01-01

IMPORTANCE Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated. OBJECTIVE To examine the associations between plasma P-tau and total-tau (T-tau) levels and injury presence, severity, type of pathoanatomic lesion (neuroimaging), and patient outcomes in acute and chronic TBI. DESIGN, SETTING, AND PARTICIPANTS In the TRACK-TBI Pilot study, plasma was collected at a single time point from 196 patients with acute TBI admitted to 3 level I trauma centers (<24 hours after injury) and 21 patients with TBI admitted to inpatient rehabilitation units (mean [SD], 176.4 [44.5] days after injury). Control samples were purchased from a commercial vendor. The TRACK-TBI Pilot study was conducted from April 1, 2010, to June 30, 2012. Data analysis for the current investigation was performed from August 1, 2015, to March 13, 2017. MAIN OUTCOMES AND MEASURES Plasma samples were assayed for P-tau (using an antibody that specifically recognizes phosphothreonine-231) and T-tau using ultra-high sensitivity laser-based immunoassay multi-arrayed fiberoptics conjugated with rolling circle amplification. RESULTS In the 217 patients with TBI, 161 (74.2%) were men; mean (SD) age was 42.5 (18.1) years. The P-tau and T-tau levels and P-tau–T-tau ratio in patients with acute TBI were higher than those in healthy controls. Receiver operating characteristic analysis for the 3 tau indices demonstrated accuracy with area under the curve (AUC) of 1.000, 0.916, and 1.000, respectively, for discriminating mild TBI (Glasgow Coma Scale [GCS] score, 13–15, n = 162) from healthy controls. The P-tau level and P-tau–T-tau ratio

A new study of muons in air showers by NBU air shower array

NASA Technical Reports Server (NTRS)

Chaudhuri, N.; Mukherjee, N.; Sarkar, S.; Basak, D. K.; Ghosh, B.

1985-01-01

The North Bengal University (NBU) air shower array has been in operation in conjunction with two muon magnetic spectrographs. The array incorporates 21 particle density sampling detectors around the magnetic spectrographs covering an area of 900 sq m. The layout of the array is based on the arrangement of detectors in a square symmetry. The array set up on the ground level is around a 10 m high magnetic spectrograph housing. This magnetic spectrograph housing limits the zenith angular acceptance of the incident showers to a few degrees. Three hundred muons in the fitted showers of size range 10 to the 4th power to 10 to the 5th power particles have so far been scanned and the momenta determined in the momentum range 2 - 440 GeV/c. More than 1500 recorded showers are now in the process of scanning and fitting. A lateral distribution of muons of energy greater than 300 MeV in the shower size range 10 to the 5th power to 7 x 10 to the 5th power has been obtained.

Probing the origin of cosmic rays with extremely high energy neutrinos using the IceCube Observatory

NASA Astrophysics Data System (ADS)

Aartsen, M. G.; Abbasi, R.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Altmann, D.; Arguelles, C.; Auffenberg, J.; Bai, X.; Baker, M.; Barwick, S. W.; Baum, V.; Bay, R.; Beatty, J. J.; Becker Tjus, J.; Becker, K.-H.; BenZvi, S.; Berghaus, P.; Berley, D.; Bernardini, E.; Bernhard, A.; Besson, D. Z.; Binder, G.; Bindig, D.; Bissok, M.; Blaufuss, E.; Blumenthal, J.; Boersma, D. J.; Bohm, C.; Bose, D.; Böser, S.; Botner, O.; Brayeur, L.; Bretz, H.-P.; Brown, A. M.; Bruijn, R.; Casey, J.; Casier, M.; Chirkin, D.; Christov, A.; Christy, B.; Clark, K.; Clevermann, F.; Coenders, S.; Cohen, S.; Cowen, D. F.; Cruz Silva, A. H.; Danninger, M.; Daughhetee, J.; Davis, J. C.; Day, M.; De Clercq, C.; De Ridder, S.; Desiati, P.; de Vries, K. D.; de With, M.; DeYoung, T.; Díaz-Vélez, J. C.; Dunkman, M.; Eagan, R.; Eberhardt, B.; Eisch, J.; Euler, S.; Evenson, P. A.; Fadiran, O.; Fazely, A. R.; Fedynitch, A.; Feintzeig, J.; Feusels, T.; Filimonov, K.; Finley, C.; Fischer-Wasels, T.; Flis, S.; Franckowiak, A.; Frantzen, K.; Fuchs, T.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Gladstone, L.; Glüsenkamp, T.; Goldschmidt, A.; Golup, G.; Gonzalez, J. G.; Goodman, J. A.; Góra, D.; Grandmont, D. T.; Grant, D.; Gretskov, P.; Groh, J. C.; Groß, A.; Ha, C.; Haj Ismail, A.; Hallen, P.; Hallgren, A.; Halzen, F.; Hanson, K.; Heereman, D.; Heinen, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Homeier, A.; Hoshina, K.; Huelsnitz, W.; Hulth, P. O.; Hultqvist, K.; Hussain, S.; Ishihara, A.; Jacobi, E.; Jacobsen, J.; Jagielski, K.; Japaridze, G. S.; Jero, K.; Jlelati, O.; Kaminsky, B.; Kappes, A.; Karg, T.; Karle, A.; Kauer, M.; Kelley, J. L.; Kiryluk, J.; Kläs, J.; Klein, S. R.; Köhne, J.-H.; Kohnen, G.; Kolanoski, H.; Köpke, L.; Kopper, C.; Kopper, S.; Koskinen, D. J.; Kowalski, M.; Krasberg, M.; Kriesten, A.; Krings, K.; Kroll, G.; Kunnen, J.; Kurahashi, N.; Kuwabara, T.; Labare, M.; Landsman, H.; Larson, M. J.; Lesiak-Bzdak, M.; Leuermann, M.; Leute, J.; Lünemann, J.; Macías, O.; Madsen, J.; Maggi, G.; Maruyama, R.; Mase, K.; Matis, H. S.; McNally, F.; Meagher, K.; Merck, M.; Meures, T.; Miarecki, S.; Middell, E.; Milke, N.; Miller, J.; Mohrmann, L.; Montaruli, T.; Morse, R.; Nahnhauer, R.; Naumann, U.; Niederhausen, H.; Nowicki, S. C.; Nygren, D. R.; Obertacke, A.; Odrowski, S.; Olivas, A.; Omairat, A.; O'Murchadha, A.; Paul, L.; Pepper, J. A.; Pérez de los Heros, C.; Pfendner, C.; Pieloth, D.; Pinat, E.; Posselt, J.; Price, P. B.; Przybylski, G. T.; Rädel, L.; Rameez, M.; Rawlins, K.; Redl, P.; Reimann, R.; Resconi, E.; Rhode, W.; Ribordy, M.; Richman, M.; Riedel, B.; Rodrigues, J. P.; Rott, C.; Ruhe, T.; Ruzybayev, B.; Ryckbosch, D.; Saba, S. M.; Sander, H.-G.; Santander, M.; Sarkar, S.; Schatto, K.; Scheriau, F.; Schmidt, T.; Schmitz, M.; Schoenen, S.; Schöneberg, S.; Schönwald, A.; Schukraft, A.; Schulte, L.; Schulz, O.; Seckel, D.; Sestayo, Y.; Seunarine, S.; Shanidze, R.; Sheremata, C.; Smith, M. W. E.; Soldin, D.; Spiczak, G. M.; Spiering, C.; Stamatikos, M.; Stanev, T.; Stanisha, N. A.; Stasik, A.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Strahler, E. A.; Ström, R.; Sullivan, G. W.; Taavola, H.; Taboada, I.; Tamburro, A.; Tepe, A.; Ter-Antonyan, S.; Tešić, G.; Tilav, S.; Toale, P. A.; Tobin, M. N.; Toscano, S.; Unger, E.; Usner, M.; Vallecorsa, S.; van Eijndhoven, N.; Van Overloop, A.; van Santen, J.; Vehring, M.; Voge, M.; Vraeghe, M.; Walck, C.; Waldenmaier, T.; Wallraff, M.; Weaver, Ch.; Wellons, M.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wiebe, K.; Wiebusch, C. H.; Williams, D. R.; Wissing, H.; Wolf, M.; Wood, T. R.; Woschnagg, K.; Xu, D. L.; Xu, X. W.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Zarzhitsky, P.; Ziemann, J.; Zierke, S.; Zoll, M.

2013-12-01

We have searched for extremely high energy neutrinos using data taken with the IceCube detector between May 2010 and May 2012. Two neutrino-induced particle shower events with energies around 1 PeV were observed, as reported previously. In this work, we investigate whether these events could originate from cosmogenic neutrinos produced in the interactions of ultrahigh energy cosmic rays with ambient photons while propagating through intergalactic space. Exploiting IceCube’s large exposure for extremely high energy neutrinos and the lack of observed events above 100 PeV, we can rule out the corresponding models at more than 90% confidence level. The model-independent quasidifferential 90% C.L. upper limit, which amounts to E2ϕνe+νμ+ντ=1.2×10-7GeVcm-2s-1sr-1 at 1 EeV, provides the most stringent constraint in the energy range from 10 PeV to 10 EeV. Our observation disfavors strong cosmological evolution of the highest energy cosmic-ray sources such as the Fanaroff-Riley type II class of radio galaxies.

Search for point sources of high energy neutrinos with Amanda

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahrens, J.

2002-08-01

Report of search for likely point sources for neutrinos observed by the Amanda detector. Places intensity limits on observable point sources. This paper describes the search for astronomical sources of high-energy neutrinos using the AMANDA-B10 detector, an array of 302 photomultiplier tubes, used for the detection of Cherenkov light from upward traveling neutrino-induced muons, buried deep in ice at the South Pole. The absolute pointing accuracy and angular resolution were studied by using coincident events between the AMANDA detector and two independent telescopes on the surface, the GASP air Cherenkov telescope and the SPASE extensive air shower array. Using datamore » collected from April to October of 1997 (130.1 days of livetime), a general survey of the northern hemisphere revealed no statistically significant excess of events from any direction. The sensitivity for a flux of muon neutrinos is based on the effective detection area for through-going muons. Averaged over the Northern sky, the effective detection area exceeds 10,000 m{sup 2} for E{sub {mu}} {approx} 10 TeV. Neutrinos generated in the atmosphere by cosmic ray interactions were used to verify the predicted performance of the detector. For a source with a differential energy spectrum proportional to E{sub {nu}}{sup -2} and declination larger than +40{sup o}, we obtain E{sup 2} (dN{sub {nu}}/dE) {le} 10{sup -6} GeV cm{sup -2} s{sup -1} for an energy threshold of 10 GeV.« less

Recent Ultra High Energy neutrino bounds and multimessenger observations with the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Zas, Enrique

2018-01-01

The overall picture of the highest energy particles produced in the Universe is changing because of measurements made with the Pierre Auger Observatory. Composition studies of cosmic rays point towards an unexpected mixed composition of intermediate mass nuclei, more isotropic than anticipated, which is reshaping the future of the field and underlining the priority to understand composition at the highest energies. The Observatory is competitive in the search for neutrinos of all flavors above about 100 PeV by looking for very inclined showers produced deep in the atmosphere by neutrinos interacting either in the atmosphere or in the Earth's crust. It covers a large field of view between -85° and 60° declination in equatorial coordinates. Neutrinos are expected because of the existence of ultra high energy cosmic rays. They provide valuable complementary information, their fluxes being sensitive to the primary cosmic ray masses and their directions reflecting the source positions. We report the results of the neutrino search providing competitive bounds to neutrino production and strong constraints to a number of production models including cosmogenic neutrinos due to ultra high energy protons. We also report on two recent contributions of the Observatory to multimessenger studies by searching for correlations of neutrinos both with cosmic rays and with gravitational waves. The correlations of the directions of the highest energy astrophysical neutrinos discovered with IceCube with the highest energy cosmic rays detected with the Auger Observatory and the Telescope Array revealed an excess that is not statistically significant and is being monitored. The targeted search for neutrinos correlated with the discovery of the gravitational wave events GW150914 and GW151226 with advanced LIGO has led to the first bounds on the energy emitted by black hole mergers in Ultra-High Energy Neutrinos.

Biofilms in shower hoses.

PubMed

Proctor, Caitlin R; Reimann, Mauro; Vriens, Bas; Hammes, Frederik

2017-12-14

Shower hoses offer an excellent bacterial growth environment in close proximity to a critical end-user exposure route within building drinking water plumbing. However, the health risks associated with and processes underlying the development of biofilms in shower hoses are poorly studied. In a global survey, biofilms from 78 shower hoses from 11 countries were characterized in terms of cell concentration (4.1 × 10 4 -5.8 × 10 8  cells/cm 2 ), metal accumulation (including iron, lead, and copper), and microbiome composition (including presence of potential opportunistic pathogens). In countries using disinfectant, biofilms had on average lower cell concentrations and diversity. Metal accumulation (up to 5 μg-Fe/cm 2 , 75 ng-Pb/cm 2 , and 460 ng-Cu/cm 2 ) seemed to be partially responsible for discoloration in biofilms, and likely originated from other pipes upstream in the building. While some genera that may contain potential opportunistic pathogens (Legionella, detected in 21/78 shower hoses) were positively correlated with biofilm cell concentration, others (Mycobacterium, Pseudomonas) had surprisingly non-existent or negative correlations with biofilm cell concentrations. In a controlled study, 15 identical shower hoses were installed for the same time period in the same country, and both stagnant and flowing water samples were collected. Ecological theory of dispersal and selection helped to explain microbiome composition and diversity of different sample types. Shower hose age was related to metal accumulation but not biofilm cell concentration, while frequency of use appeared to influence biofilm cell concentration. This study shows that shower hose biofilms are clearly a critical element of building drinking water plumbing, and a potential target for building drinking water plumbing monitoring. Copyright © 2017 Elsevier Ltd. All rights reserved.

Minimal Prospects for Radio Detection of Extensive Air Showers in the Atmosphere of Jupiter

NASA Astrophysics Data System (ADS)

Bray, J. D.; Nelles, A.

2016-07-01

One possible approach for detecting ultra-high-energy cosmic rays and neutrinos is to search for radio emission from extensive air showers created when they interact in the atmosphere of Jupiter, effectively utilizing Jupiter as a particle detector. We investigate the potential of this approach. For searches with current or planned radio telescopes we find that the effective area for detection of cosmic rays is substantial (˜3 × 107 km2), but the acceptance angle is so small that the typical geometric aperture (˜103 km2 sr) is less than that of existing terrestrial detectors, and cosmic rays also cannot be detected below an extremely high threshold energy (˜1023 eV). The geometric aperture for neutrinos is slightly larger, and greater sensitivity can be achieved with a radio detector on a Jupiter-orbiting satellite, but in neither case is this sufficient to constitute a practical detection technique. Exploitation of the large surface area of Jupiter for detecting ultra-high-energy particles remains a long-term prospect that will require a different technique, such as orbital fluorescence detection.

Closing the tau loop: the missing tau mutation

PubMed Central

McCarthy, Allan; Lonergan, Roisin; Olszewska, Diana A.; O’Dowd, Sean; Cummins, Gemma; Magennis, Brian; Fallon, Emer M.; Pender, Niall; Huey, Edward D.; Cosentino, Stephanie; O’Rourke, Killian; Kelly, Brendan D.; O’Connell, Martin; Delon, Isabelle; Farrell, Michael; Spillantini, Maria Grazia; Rowland, Lewis P.; Fahn, Stanley; Craig, Peter; Hutton, Michael

2015-01-01

Frontotemporal lobar degeneration comprises a group of disorders characterized by behavioural, executive, language impairment and sometimes features of parkinsonism and motor neuron disease. In 1994 we described an Irish-American family with frontotemporal dementia linked to chromosome 17 associated with extensive tau pathology. We named this disinhibition-dementia-parkinsonism-amyotrophy complex. We subsequently identified mutations in the MAPT gene. Eleven MAPT gene splice site stem loop mutations were identified over time except for 5’ splice site of exon 10. We recently identified another Irish family with autosomal dominant early amnesia and behavioural change or parkinsonism associated with the ‘missing’ +15 mutation at the intronic boundary of exon 10. We performed a clinical, neuropsychological and neuroimaging study on the proband and four siblings, including two affected siblings. We sequenced MAPT and performed segregation analysis. We looked for a biological effect of the tau variant by performing real-time polymerase chain reaction analysis of RNA extracted from human embryonic kidney cells transfected with exon trapping constructs. We found a c.915+15A>C exon 10/intron 10 stem loop mutation in all affected subjects but not in the unaffected. The c.915+15A>C variant caused a shift in tau splicing pattern to a predominantly exon 10+ pattern presumably resulting in predominant 4 repeat tau and little 3 repeat tau. This strongly suggests that the c.915+15A>C variant is a mutation and that it causes frontotemporal dementia linked to chromosome 17 in this pedigree by shifting tau transcription and translation to +4 repeat tau. Tau (MAPT) screening should be considered in families where amnesia or atypical parkinsonism coexists with behavioural disturbance early in the disease process. We describe the final missing stem loop tau mutation predicted 15 years ago. Mutations have now been identified at all predicted sites within the ‘stem’ when the

Meteor showers of the southern hemisphere

NASA Astrophysics Data System (ADS)

Molau, Sirko; Kerr, Steve

2014-04-01

We present the results of an exhaustive meteor shower search in the southern hemisphere. The underlying data set is a subset of the IMO Video Meteor Database comprising 50,000 single station meteors obtained by three Australian cameras between 2001 and 2012. The detection technique was similar to previous single station analysis. In the data set we find 4 major and 6 minor northern hemisphere meteor showers, and 12 segments of the Antihelion source (including the Northern and Southern Taurids and six streams from the MDC working list). We present details for 14 southern hemisphere showers plus the Centaurid and Puppid-Velid complex, with the η Aquariids and the Southern δ Aquariids being the strongest southern showers. Two of the showers (θ^2 Sagittariids and τ Cetids) were previously unknown and have received preliminary designations by the MDC. Overall we find that the fraction of southern meteor showers south of -30deg declination (roughly 25%) is clearly smaller than the fraction of northern meteor showers north of +30deg declination (more than 50%) obtained in our previous analysis.

Detecting tau in serum of transgenic animal models after tau immunotherapy treatment.

PubMed

d'Abramo, Cristina; Acker, Christopher M; Schachter, Joel B; Terracina, Giuseppe; Wang, Xiaohai; Forest, Stefanie K; Davies, Peter

2016-01-01

In the attempt to elucidate if the "peripheral sink hypothesis" could be a potential mechanism of action for tau removal in passive immunotherapy experiments, we have examined tau levels in serum of chronically injected JNPL3 and Tg4510 transgenic animals. Measurement of tau in serum of mice treated with tau antibodies is challenging because of the antibody interference in sandwich enzyme-linked immunosorbent assays. To address this issue, we have developed a heat-treatment protocol at acidic pH to remove interfering molecules from serum, with excellent recovery of tau. The present data show that pan-tau and conformational antibodies do increase tau in mouse sera. However, these concentrations in serum do not consistently correlate with reductions of tau pathology in brain, suggesting that large elevations of tau species measured in serum are not predictive of efficacy. Here, we describe a reliable method to detect tau in serum of transgenic animals that have undergone tau immunotherapy. Levels of tau in human serum are less than the sensitivity of current assays, although artifactual signals are common. The method may be useful in similarly treated humans, a situation in which false positive signals are likely. Copyright © 2016 Elsevier Inc. All rights reserved.

A Nine-Year Hunt for Neutrinos

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2018-02-01

.Observatories on the HuntNeutrino observatories are often built to take advantage of pre-existing deep bodies of ice or water for their detectors. One of the most well-known neutrino observatories is IceCube, an array of detectors located far beneath the Antarctic ice. A few years ago, IceCube announced the observation of an excess of events over the expected atmospheric background the first detection of a diffuse flux of cosmic neutrinos. The next step:confirmation from another observatory.ANTARES detections across different energy bins, for both track-like (top) and shower-like (bottom) events. Plot includes data (black), model for atmospheric events (blue), and two different models for cosmic events (red). Above an energy cutoff of 20 TeV (grey line), nine excess neutrinos are detected relative to the atmospheric model. [Albert et al. 2018]Enter ANTARES, short for Astronomy with a Neutrino Telescope and Abyss Environmental Research. Completed in 2008, this neutrino telescope was built 1.5 miles beneath the surface of the Mediterranean Sea. Now the collaboration is presenting the results of their nine-year search for a diffuse cosmic neutrino flux.A Mild ExcessThe outcome? Success! sort of.The very nature of neutrinos elusiveness means that we have to draw conclusions with very small numbers of detections. Over nine years, ANTARES detected a total of 33 events above an energy cutoff of 20 TeV, whereas models predict it should have seen only 24 such events due to atmospheric particles. This detection of nine extra neutrinos may sound insubstantial but statistically, it allows the team to reject the hypothesis that there is no diffuse cosmic flux at an 85% confidence level.The mild excess of neutrinos detected by ANTARES is by no means a smoking gun, but the properties of this cosmic neutrino flux are consistent with those detected by IceCube, which is a very promising outcome. At the moment, it would seem that a diffuse flux of cosmic neutrinos is present and the next generation

The “Carpet-3” air shower array to search for diffuse gamma rays with energy Eγ>100TeV

NASA Astrophysics Data System (ADS)

Dzhappuev, D. D.; I, V. B. Petkov V.; Kudzhaev, A. U.; Lidvansky, A. S.; Volchenko, V. I.; Volchenko, G. V.; Gorbacheva, E. A.; Dzaparova, I. M.; Klimenko, N. F.; Kurenya, A. N.; Mikhilova, O. I.; Khadzhiev, M. M.; Yanin, A. F.

2017-12-01

At present an experiment for measuring the flux of cosmic diffuse gamma rays with energy higher than 100 TeV (experiment “Carpet-3”) is being prepared at the Baksan Neutrino Observatory of the Institute for Nuclear Research, Russian Academy of Sciences. The preparation of the experiment implies considerable enlargement of the area of both muon detector and surface part of the shower array. At the moment the plastic scintillation counters with a total continuous area of 410 m2 are installed in the muon detector (MD) underground tunnels, and they are totally equipped with electronics. Adjusting of the counters and their electronic circuits is in progress. Six modules of shower detectors (out of twenty planned to be installed) have already been placed on the surface of the MD absorber. A new liquid scintillation detector is developed for modules of the ground -surface part of the array, whose characteristics are presented. It is shown that the “Carpet-3” air shower array will have the best sensitivity to the flux of primary gamma rays with energies in the range 100TeV - 1PeV, being quite competitive in gamma-ray astronomy at such energies.

Tau Phosphorylation Pathway Genes and Cerebrospinal Fluid Tau Levels in Alzheimer’s Disease

PubMed Central

Bekris, Lynn M.; Millard, Steve; Lutz, Franziska; Li, Gail; Galasko, Doug R.; Farlow, Martin R.; Quinn, Joseph F.; Kaye, Jeffrey A.; Leverenz, James B.; Tsuang, Debby W.; Yu, Chang-En; Peskind, Elaine R.

2013-01-01

Alzheimer’s disease (AD) is characterized by the presence in the brain of amyloid plaques, consisting predominately of the amyloid β peptide (Aβ), and neurofibrillary tangles, consisting primarily of tau. Hyper-phosphorylated-tau (p-tau) contributes to neuronal damage, and both p-tau and total-tau (t-tau) levels are elevated in AD cerebrospinal fluid (CSF) compared to cognitively normal controls. Our hypothesis was that increased ratios of CSF phosphorylated-tau levels relative to total-tau levels correlate with regulatory region genetic variation of kinase or phosphatase genes biologically associated with the phosphorylation status of tau. Eighteen SNPs located within 5′ and 3′ regions of 5 kinase and 4 phosphatase genes, as well as two SNPs within regulatory regions of the MAPT gene were chosen for this analysis. The study sample consisted of 101 AD patients and 169 cognitively normal controls. Rs7768046 in the FYN kinase gene and rs913275 in the PPP2R4 phosphatase gene were both associated with CSF p-tau and t-tau levels in AD. These SNPs were also differentially associated with either CSF t-tau (rs7768046) or CSF p-tau (rs913275) relative to t-tau levels in AD compared to controls. These results suggest that rs7768046 and rs913275 both influence CSF tau levels in an AD-associated manner. PMID:22927204

Physiological and subjective responses to standing showers, sitting showers, and sink baths.

PubMed

Ohnaka, T; Tochihara, Y; Kubo, M; Yamaguchi, C

1995-09-01

The purpose of this study was to investigate physiological and subjective responses during and after bathing in three different bathing methods. Eight healthy males bathed for 10 minutes, and then rested for 30 minutes. Three kinds of bathing methods - standing shower, sitting shower and sink bath - were adopted in this experiment. Water temperature and flow volume of the showers were kept at 41 degrees C and 11 liter/min, while water temperature of the bath was kept at 40 degrees C. Rectal temperature, skin temperatures and heart rate of the subjects were measured continuously during bathing and the subsequent 30-minute rest. Blood pressure and votes for thermal sensations were recorded before bathing, after 5 and 10 minutes of bathing, and 5, 10, 20 and 30 minutes after bathing. The following results were obtained. 1) Although rectal temperature rose, on the average, by 0.15 degrees C in all bathing methods, there were no significant differences among the three bathing methods at any time in the experiment. 2) Mean skin temperature (Tsk) during the sink bath was significantly higher than that in the standing or sitting shower. After bathing, Tsk of sink bath was slightly higher than those of the remaining conditions, but did not significantly differ among the bathing methods. 3) Heart rate increased gradually during all the bathing methods, however, only HR in the standing shower exceeded 100 beats/min which was significantly higher than those of the two remaining bathing methods. 4) Blood pressure (BP) decreased rapidly during the sink bath in contrast to an increased BP in the sitting and standing showers.

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils

PubMed Central

Banks, Rachel A.; Kim, Bumjin; Xu, Hong; Changolkar, Lakshmi; Leight, Susan N.; Riddle, Dawn M.; Li, Chi; Brown, Hannah J.; Zhang, Bin

2017-01-01

Neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau), and related disorders. Pathological tau proteins derived from human AD brains (AD-tau) act as proteopathic seeds that initiate the templated aggregation of soluble tau upon intracerebral injection into tau transgenic (Tg) and wild-type mice, thereby modeling human tau pathology. In this study, we found that aged Tg mice of both sexes expressing human tau proteins harboring a pathogenic P301L MAPT mutation labeled with green fluorescent protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentritic domain of neurons, but these mice did not develop de novo insoluble tau aggregates, which are characteristic of human AD and related tauopathies. However, intracerebral injections of either T40PL preformed fibrils (PFFs) or AD-tau seeds into T40PL-GFP mice induced abundant intraneuronal pathological inclusions of hyperphosphorylated T40PL-GFP. These injections of pathological tau resulted in the propagation of tau pathology from the injection site to neuroanatomically connected brain regions, and these tau inclusions consisted of both T40PL-GFP and WT endogenous mouse tau. Primary neurons cultured from the brains of neonatal T40PL-GFP mice provided an informative in vitro model for examining the uptake and localization of tau PFFs. These findings demonstrate the seeded aggregation of T40PL-GFP in vivo by synthetic PFFs and human AD-tau and the utility of this system to study the neuropathological spread of tau aggregates. SIGNIFICANCE STATEMENT The stereotypical spread of pathological tau protein aggregates have recently been attributed to the transmission of proteopathic seeds. Despite the extensive use of transgenic mouse models to investigate the propagation of tau pathology in vivo, details of the aggregation

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.

PubMed

Gibbons, Garrett S; Banks, Rachel A; Kim, Bumjin; Xu, Hong; Changolkar, Lakshmi; Leight, Susan N; Riddle, Dawn M; Li, Chi; Gathagan, Ronald J; Brown, Hannah J; Zhang, Bin; Trojanowski, John Q; Lee, Virginia M-Y

2017-11-22

Neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau), and related disorders. Pathological tau proteins derived from human AD brains (AD-tau) act as proteopathic seeds that initiate the templated aggregation of soluble tau upon intracerebral injection into tau transgenic (Tg) and wild-type mice, thereby modeling human tau pathology. In this study, we found that aged Tg mice of both sexes expressing human tau proteins harboring a pathogenic P301L MAPT mutation labeled with green fluorescent protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentritic domain of neurons, but these mice did not develop de novo insoluble tau aggregates, which are characteristic of human AD and related tauopathies. However, intracerebral injections of either T40PL preformed fibrils (PFFs) or AD-tau seeds into T40PL-GFP mice induced abundant intraneuronal pathological inclusions of hyperphosphorylated T40PL-GFP. These injections of pathological tau resulted in the propagation of tau pathology from the injection site to neuroanatomically connected brain regions, and these tau inclusions consisted of both T40PL-GFP and WT endogenous mouse tau. Primary neurons cultured from the brains of neonatal T40PL-GFP mice provided an informative in vitro model for examining the uptake and localization of tau PFFs. These findings demonstrate the seeded aggregation of T40PL-GFP in vivo by synthetic PFFs and human AD-tau and the utility of this system to study the neuropathological spread of tau aggregates. SIGNIFICANCE STATEMENT The stereotypical spread of pathological tau protein aggregates have recently been attributed to the transmission of proteopathic seeds. Despite the extensive use of transgenic mouse models to investigate the propagation of tau pathology in vivo , details of the aggregation

Extensive air showers (HE-4)

NASA Technical Reports Server (NTRS)

Clay, R. W.

1986-01-01

Ultra high energy (UHE) gamma ray astronomy is an exciting area which has added a new sense of purpose to ground based array work. There is much to be done before UHE gamma ray showers can be understood properly and it is important to remain conservative with claims while the properties of such showers are still not clear. The muon content is only one of the properties that needs to be clarified. It remains to be seen how well progress occurs on the second order problem of detailed interaction parameters once the gross features are clarified. The shower disk thickness has become an area of intense study with interest in Linsley's technique for measuremnts of giant showers and in the study of structure near the core for improving fast timing and studying delayed subshowers. Perhaps the most significant area of promise for the future is individual shower develpments with Cerenkov and, particularly, air fluorescence techniques. The importance and potential of having relatively complete information on a complete set of individual showers can hardly be overestimated. A complete understanding of the observation process is needed to determine whether or not the recorded data set is complete at a given energy, apparent core distance, and zenith angle.

The composition of cosmic rays near the Bend (10 to the 15th power eV) from a study of muons in air showers at sea level

NASA Technical Reports Server (NTRS)

Goodman, J. A.; Gupta, S. C.; Freudenreich, H. T.; Sivaprasad, K.; Tonwar, S. C.; Yodh, G. B.; Ellsworth, R. W.; Goodman, M. C.; Bogert, M. C.; Burnstein, R.

1985-01-01

The distribution of muons near shower cores was studied at sea level at Fermilab using the E594 neutrino detector to sample the muon with E testing 3 GeV. These data are compared with detailed Monte Carlo simulations to derive conclusions about the composition of cosmic rays near the bend in the all particle spectrum. Monte Carlo simulations generating extensive air showers (EAS) with primary energy in excess of 50 TeV are described. Each shower record contains details of the electron lateral distribution and the muon and hadron lateral distributions as a function of energy, at the observation level of 100g/cm. The number of detected electrons and muons in each case was determined by a Poisson fluctuation of the number incident. The resultant predicted distribution of muons, electrons, the rate events are compared to those observed. Preliminary results on the rate favor a heavy primary dominated cosmic ray spectrum in energy range 50 to 1000 TeV.

Measurements of top quark pair production cross section in proton anti-proton collisions at √s = 1.96 TeV in the τ + jets final state using 1 fb -1 of data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hossain, Sohrab

This dissertation presents a new measurement of pmore » $$\\bar{p}$$ → t$$\\bar{t}$$X production at √s = 1.96 TeV using 974.2 pb -1of data collected with the D0 detector between 2002 and 2006. We focus on the final state where the W boson from one of the top quarks decays into a τ lepton and its associated neutrino, while the other W boson decays into a quark-antiquark pair. We aim to select those events in which the τ lepton subsequently decays hadronically, meaning to one or three charged hadrons, zero or more neutral hadrons and a tau neutrino (the charge conjugate processes are implied in all of the above). The observable signature thus consists of a narrow calorimeter shower with associated track(s) characteristic of a hadronic tau decay, four or more jets, of which two are initiated by b quarks accompanying the W's in the top quark decays, and a large net missing momentum in the transverse plane due to the energetic neutrino-antineutrino pair that leave no trace in the detector media. The preliminary result for the measured cross section is: σ(t$$\\bar{t}$$) = 6.9 -1.2 +1.2(stat) -0.7 +0.8(syst) ± 0.4 (lumi) pb. This indicates that our finding is consistent with the Standard Model prediction.« less

A survey of southern hemisphere meteor showers

NASA Astrophysics Data System (ADS)

Jenniskens, Peter; Baggaley, Jack; Crumpton, Ian; Aldous, Peter; Pokorny, Petr; Janches, Diego; Gural, Peter S.; Samuels, Dave; Albers, Jim; Howell, Andreas; Johannink, Carl; Breukers, Martin; Odeh, Mohammad; Moskovitz, Nicholas; Collison, Jack; Ganju, Siddha

2018-05-01

Results are presented from a video-based meteoroid orbit survey conducted in New Zealand between Sept. 2014 and Dec. 2016, which netted 24,906 orbits from +5 to -5 magnitude meteors. 44 new southern hemisphere meteor showers are identified after combining this data with that of other video-based networks. Results are compared to showers reported from recent radar-based surveys. We find that video cameras and radar often see different showers and sometimes measure different semi-major axis distributions for the same meteoroid stream. For identifying showers in sparse daily orbit data, a shower look-up table of radiant position and speed as a function of time was created. This can replace the commonly used method of identifying showers from a set of mean orbital elements by using a discriminant criterion, which does not fully describe the distribution of meteor shower radiants over time.

First search for atmospheric and extraterrestrial neutrino-induced cascades with the IceCube detector

NASA Astrophysics Data System (ADS)

Abbasi, R.; Abdou, Y.; Abu-Zayyad, T.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Andeen, K.; Auffenberg, J.; Bai, X.; Baker, M.; Barwick, S. W.; Bay, R.; Bazo Alba, J. L.; Beattie, K.; Beatty, J. J.; Bechet, S.; Becker, J. K.; Becker, K.-H.; Benabderrahmane, M. L.; Benzvi, S.; Berdermann, J.; Berghaus, P.; Berley, D.; Bernardini, E.; Bertrand, D.; Besson, D. Z.; Bindig, D.; Bissok, M.; Blaufuss, E.; Blumenthal, J.; Boersma, D. J.; Bohm, C.; Bose, D.; Böser, S.; Botner, O.; Braun, J.; Brown, A. M.; Buitink, S.; Carson, M.; Chirkin, D.; Christy, B.; Clem, J.; Clevermann, F.; Cohen, S.; Colnard, C.; Cowen, D. F.; D'Agostino, M. V.; Danninger, M.; Daughhetee, J.; Davis, J. C.; de Clercq, C.; Demirörs, L.; Depaepe, O.; Descamps, F.; Desiati, P.; de Vries-Uiterweerd, G.; Deyoung, T.; Díaz-Vélez, J. C.; Dierckxsens, M.; Dreyer, J.; Dumm, J. P.; Ehrlich, R.; Eisch, J.; Ellsworth, R. W.; Engdegård, O.; Euler, S.; Evenson, P. A.; Fadiran, O.; Fazely, A. R.; Fedynitch, A.; Feusels, T.; Filimonov, K.; Finley, C.; Fischer-Wasels, T.; Foerster, M. M.; Fox, B. D.; Franckowiak, A.; Franke, R.; Gaisser, T. K.; Gallagher, J.; Geisler, M.; Gerhardt, L.; Gladstone, L.; Glüsenkamp, T.; Goldschmidt, A.; Goodman, J. A.; Grant, D.; Griesel, T.; Groß, A.; Grullon, S.; Gurtner, M.; Ha, C.; Hallgren, A.; Halzen, F.; Han, K.; Hanson, K.; Heinen, D.; Helbing, K.; Herquet, P.; Hickford, S.; Hill, G. C.; Hoffman, K. D.; Homeier, A.; Hoshina, K.; Hubert, D.; Huelsnitz, W.; Hülß, J.-P.; Hulth, P. O.; Hultqvist, K.; Hussain, S.; Ishihara, A.; Jacobsen, J.; Japaridze, G. S.; Johansson, H.; Joseph, J. M.; Kampert, K.-H.; Kappes, A.; Karg, T.; Karle, A.; Kelley, J. L.; Kemming, N.; Kenny, P.; Kiryluk, J.; Kislat, F.; Klein, S. R.; Köhne, J.-H.; Kohnen, G.; Kolanoski, H.; Köpke, L.; Kopper, S.; Koskinen, D. J.; Kowalski, M.; Kowarik, T.; Krasberg, M.; Krings, T.; Kroll, G.; Kuehn, K.; Kuwabara, T.; Labare, M.; Lafebre, S.; Laihem, K.; Landsman, H.; Larson, M. J.; Lauer, R.; Lehmann, R.; Lünemann, J.; Madsen, J.; Majumdar, P.; Marotta, A.; Maruyama, R.; Mase, K.; Matis, H. S.; Meagher, K.; Merck, M.; Mészáros, P.; Meures, T.; Middell, E.; Milke, N.; Miller, J.; Montaruli, T.; Morse, R.; Movit, S. M.; Nahnhauer, R.; Nam, J. W.; Naumann, U.; Nießen, P.; Nygren, D. R.; Odrowski, S.; Olivas, A.; Olivo, M.; O'Murchadha, A.; Ono, M.; Panknin, S.; Paul, L.; Pérez de Los Heros, C.; Petrovic, J.; Piegsa, A.; Pieloth, D.; Porrata, R.; Posselt, J.; Price, P. B.; Prikockis, M.; Przybylski, G. T.; Rawlins, K.; Redl, P.; Resconi, E.; Rhode, W.; Ribordy, M.; Rizzo, A.; Rodrigues, J. P.; Roth, P.; Rothmaier, F.; Rott, C.; Ruhe, T.; Rutledge, D.; Ruzybayev, B.; Ryckbosch, D.; Sander, H.-G.; Santander, M.; Sarkar, S.; Schatto, K.; Schmidt, T.; Schoenwald, A.; Schukraft, A.; Schultes, A.; Schulz, O.; Schunck, M.; Seckel, D.; Semburg, B.; Seo, S. H.; Sestayo, Y.; Seunarine, S.; Silvestri, A.; Slipak, A.; Spiczak, G. M.; Spiering, C.; Stamatikos, M.; Stanev, T.; Stephens, G.; Stezelberger, T.; Stokstad, R. G.; Stoyanov, S.; Strahler, E. A.; Straszheim, T.; Sullivan, G. W.; Swillens, Q.; Taavola, H.; Taboada, I.; Tamburro, A.; Tarasova, O.; Tepe, A.; Ter-Antonyan, S.; Tilav, S.; Toale, P. A.; Toscano, S.; Tosi, D.; Turčan, D.; van Eijndhoven, N.; Vandenbroucke, J.; van Overloop, A.; van Santen, J.; Vehring, M.; Voge, M.; Voigt, B.; Walck, C.; Waldenmaier, T.; Wallraff, M.; Walter, M.; Weaver, Ch.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wiebe, K.; Wiebusch, C. H.; Williams, D. R.; Wischnewski, R.; Wissing, H.; Wolf, M.; Woschnagg, K.; Xu, C.; Xu, X. W.; Yodh, G.; Yoshida, S.; Zarzhitsky, P.

2011-10-01

We report on the first search for atmospheric and for diffuse astrophysical neutrino-induced showers (cascades) in the IceCube detector using 257 days of data collected in the year 2007-2008 with 22 strings active. A total of 14 events with energies above 16 TeV remained after event selections in the diffuse analysis, with an expected total background contribution of 8.3±3.6. At 90% confidence we set an upper limit of E2Φ90%CL<3.6×10-7GeV·cm-2·s-1·sr-1 on the diffuse flux of neutrinos of all flavors in the energy range between 24 TeV and 6.6 PeV assuming that Φ∝E-2 and the flavor composition of the νe∶νμ∶ντ flux is 1∶1∶1 at the Earth. The atmospheric neutrino analysis was optimized for lower energies. A total of 12 events were observed with energies above 5 TeV. The observed number of events is consistent with the expected background, within the uncertainties.

Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro.

PubMed

Pérez, Mar; Medina, Miguel; Hernández, Félix; Avila, Jesús

2018-03-05

The microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates. Increasing evidence in recent years supports the notion that Tau pathology spreading throughout the brain in AD and other Tauopathies is the consequence of the propagation of specific Tau species along neuroanatomically connected brain regions in a so-called "prion-like" manner. A number of steps are assumed to be involved in this process, including secretion, cellular uptake, transcellular transfer and/or seeding, although the precise mechanisms underlying propagation of Tau pathology are not fully understood yet. This review summarizes recent evidence on the nature of the specific Tau species that are propagated and the different mechanisms of Tau pathology spreading.

46 CFR 154.1410 - Decontamination shower.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Decontamination shower. 154.1410 Section 154.1410... Equipment § 154.1410 Decontamination shower. When Table 4 references this section, a vessel carrying the listed cargo must have a decontamination shower and an eye wash that: (a) Are on the weatherdeck; and (b...

46 CFR 154.1410 - Decontamination shower.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Decontamination shower. 154.1410 Section 154.1410... Equipment § 154.1410 Decontamination shower. When Table 4 references this section, a vessel carrying the listed cargo must have a decontamination shower and an eye wash that: (a) Are on the weatherdeck; and (b...

Universality of Electron Distributions in Extensive Air Showers

NASA Astrophysics Data System (ADS)

Śmiałkowski, Andrzej; Giller, Maria

2018-02-01

Based on extensive air shower simulations, it is shown that electron distributions with respect to two angles determining the electron direction at a given shower age, for a fixed electron energy and lateral distance, are universal. This means that the distributions do not depend on the primary particle energy or mass (thus, neither on the interaction model), shower zenith angle, or shower to shower fluctuations, if they are taken at the same shower age. Together with previous work showing the universality of the distributions of the electron energy, lateral distance (integrated over angles), and angle (integrated over lateral distance) for fixed electron energy, this paper completes a full universal description of the electron states at various shower ages. Analytical parametrizations of the full electron states are given. It is also shown that some distributions can be described by a number of variables smaller than five, with the new ones being products of old ones raised to some power. The accuracy of the present parametrization is sufficiently good to apply to showers with a primary energy uncertainty of 14% (as is the case at the Pierre Auger Observatory). The shower fluctuations in the chosen bins of the multidimensional variable space are about 6%, determining the minimum uncertainty needed for the parametrization of the universal distributions. An analytical way of estimating the effect of the geomagnetic field is given. Thanks to the universality of the electron distribution in any shower, a new method of shower reconstruction can be worked out from the data from observatories using the fluorescence technique. The light fluxes (both fluorescence and Cherenkov) for any shower age can be exactly predicted for a shower with any primary energy and shower maximum depth, so that the two quantities can be obtained by best fitting the predictions to the measurements.

SHiP: a new facility to search for heavy neutrinos and study ντ properties

NASA Astrophysics Data System (ADS)

De Serio, M.; SHiP Collaboration

2016-05-01

SHiP (Search for Hidden Particles) is a newly designed fixed target facility, proposed at the CERN SPS accelerator, with the aim of complementing searches for New Physics at LHC by searching for light long-lived exotic particles with masses below a few GeV/c2. The sensitivity to Heavy Neutrinos will allow for the first time probing a region of the parameter space where Baryogenesis and active neutrino masses and oscillation could also be explained. A dedicated detector, based on OPERA-like bricks, will provide the first observation of the tau anti-neutrino. Moreover, ντ and ν¯τ cross-sections will be measured with a statistics 1000 times larger than currently available data and will allow extracting the F4 and F5 structure functions, never measured so far. Charm physics studies will be performed with significantly improved accuracy with respect to past experiments.

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice.

PubMed

Liu, Wencheng; Zhao, Lingzhi; Blackman, Brittany; Parmar, Mayur; Wong, Man Ying; Woo, Thomas; Yu, Fangmin; Chiuchiolo, Maria J; Sondhi, Dolan; Kaminsky, Stephen M; Crystal, Ronald G; Paul, Steven M

2016-12-07

Passive immunization with anti-tau monoclonal antibodies has been shown by several laboratories to reduce age-dependent tau pathology and neurodegeneration in mutant tau transgenic mice. These studies have used repeated high weekly doses of various tau antibodies administered systemically for several months and have reported reduced tau pathology of ∼40-50% in various brain regions. Here we show that direct intrahippocampal administration of the adeno-associated virus (AAV)-vectored anti-phospho-tau antibody PHF1 to P301S tau transgenic mice results in high and durable antibody expression, primarily in neurons. Hippocampal antibody levels achieved after AAV delivery were ∼50-fold more than those reported following repeated systemic administration. In contrast to systemic passive immunization, we observed markedly reduced (≥80-90%) hippocampal insoluble pathological tau species and neurofibrillary tangles following a single dose of AAV-vectored PHF1 compared with mice treated with an AAV-IgG control vector. Moreover, the hippocampal atrophy observed in untreated P301S mice was fully rescued by treatment with the AAV-vectored PHF1 antibody. Vectored passive immunotherapy with an anti-tau monoclonal antibody may represent a viable therapeutic strategy for treating or preventing such tauopathies as frontotemporal dementia, progressive supranuclear palsy, or Alzheimer's disease. We have used an adeno-associated viral (AAV) vector to deliver the genes encoding an anti-phospho-tau monoclonal antibody, PHF1, directly to the brain of mice that develop neurodegeneration due to a tau mutation that causes frontotemporal dementia (FTD). When administered systemically, PHF1 has been shown to modestly reduce tau pathology and neurodegeneration. Since such antibodies do not readily cross the blood-brain barrier, we used an AAV vector to deliver antibody directly to the hippocampus and observed much higher antibody levels and a much greater reduction in tau pathology. Using

Measurement of Muon Neutrino Disappearance with the NOvA Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vinton, Luke

The NOvA experiment consists of two functionally identical tracking calorimeter detectors which measure the neutrino energy and flavour composition of the NuMI beam at baselines of 1~km and 810~km. Measurements of neutrino oscillation parameters are extracted by comparing the neutrino energy spectrum in the far detector with predictions of the oscillated neutrino energy spectra that are made using information extracted from the near detector. Observation of muon neutrino disappearance allows NOvA to make measurements of the mass squared splittingmore » $$\\Delta m^2_{32}$$ and the mixing angle $$\\theta_{23}$$. The measurement of $$\\theta_{23}$$ will provide insight into the make-up of the third mass eigenstate and probe the muon-tau symmetry hypothesis that requires $$\\theta_{23} = \\pi/4$$. This thesis introduces three methods to improve the sensitivity of NOvA's muon neutrino disappearance analysis. First, neutrino events are separated according to an estimate of their energy resolution to distinguish well resolved events from events that are not so well resolved. Second, an optimised neutrino energy binning is implemented that uses finer binning in the region of maximum muon neutrino disappearance. Third, a hybrid selection is introduced that selects muon neutrino events with greater efficiency and purity. The combination of these improvements produces an increase in the sensitivity of the analysis equivalent to collecting 40-100\\% more data across the range of possible values of $$\\Delta m^2_{32}$$ and $$\\sin^2\\theta_{23}$$. This thesis presents new results using a 14~ktonne detector equivalent exposure of $$6.05\\times 10^{20}$$~protons~on~target. A fit to the far detector data, assuming normal hierarchy, produces $$\\Delta m^2_{32}=2.45^{+0.087}_{-0.079}\\times10^{-3}~\\text{eV}^2$$ and $$\\sin^2\\theta_{23}$$ in the range 0.429~-~0.593 with two statistically degenerate best fit points at 0.481 and 0.547. This measurement is consistent with maximal

Structure of air shower disc near the core

NASA Technical Reports Server (NTRS)

Inoue, N.; Kawamoto, M.; Misaki, Y.; Maeda, T.; Takeuchi, T.; Toyoda, Y.

1985-01-01

The longitudinal structure of the air shower disk is studied by measuring the arrival time distributions of air shower particles for showers with electron size in the range 3.2 x 10 to the 5.5. power to 3.2 x 10 to the 7.5 power in the Akeno air-shower array (930 gcm squared atmospheric depth). The average FWHM as a parameter of thickness of air shower disk increases with core distances at less than 50m. AT the present stage, dependence on electron size, zenith angle and air shower age is not apparent. The average thickness of the air shower disk within a core distance of 50m could be determined by an electromagnetic cascade starting from the lower altitude.

Long baseline neutrino oscillation experiment at the AGS. Physics design report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beavis, D.; Carroll, A.; Chiang, I.

1995-04-01

The authors present a design for a multi-detector long baseline neutrino oscillation experiment at the BNL AGS. It has been approved by the BNL-HENP-PAC as AGS Experiment 889. The experiment will search for oscillations in the {nu}{sub {mu}}, disappearance channel and the {nu}{sub {mu}} {leftrightarrow} {nu}{sub e} appearance channel by means of four identical neutrino detectors located 1, 3, 24, and 68km from the AGS neutrino source. Observed depletion of the {nu}{sub {mu}} flux (via quasi-elastic muon neutrino events, {nu}{sub {mu}}n {yields} {mu}{sup {minus}}p) in the far detectors not attended by an observed proportional increase of the {nu}{sub e} fluxmore » (via quasi-elastic electron neutrino events, {nu}{sub e}n {yields} e{sup {minus}}p) in those detectors will be prima facie evidence for the oscillation channel {nu}{sub {mu}} {leftrightarrow} {nu}{sub {tau}}. The experiment is directed toward exploration of the region of the neutrino oscillation parameters {Delta}m{sup 2} and sin{sup 2}2{theta}, suggested by the Kamiokande and IMB deep underground detectors but it will also explore a region more than two orders of magnitude larger than that of previous accelerator experiments. The experiment will run in a mode new to BNL. It will receive the fast extracted proton beam on the neutrino target approximately 20 hours per day when the AGS is not filling RHIC. A key aspect of the experimental design involves placing the detectors 1.5 degrees off the center line of the neutrino beam, which has the important advantage that the central value of the neutrino energy ({approx} 1 GeV) and the beam spectral shape are, to a good approximation, the same in all four detectors. The proposed detectors are massive, imaging, water Cherenkov detectors similar in large part to the Kamiokande and IMB detectors. The design has profited from their decade-long experience, and from the detector designs of the forthcoming SNO and SuperKamiokande detectors.« less

A Search for supersymmetric Higgs bosons in the di-tau decay mode in p anti-p collisions at s**(1/2) = 1.8-TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Acosta, D.; Affolder, Anthony A.; Albrow, M.G.

2005-06-01

A search for direct production of Higgs bosons in the di-tau decay mode is performed with 86.3 {+-} 3.5 pb{sup -1} of data collected with the Collider Detector at Fermilab during the 1994-1995 data taking period of the Tevatron. We search for events where one tau decays to an electron plus neutrinos and the other tau decays hadronically. We perform a counting experiment and set limits on the cross section for supersymmetric Higgs boson production where tan {beta} is large and m{sub A} is small. For a benchmark parameter space point where m{sub A{sup 0}} = 100 GeV/c{sup 2} andmore » tan {beta} = 50, we limit the production cross section multiplied by the branching ratio to be less than 77.9 pb at the 95% confidence level compared to theoretically predicted value of 11.0 pb. This is the first search for Higgs bosons decaying to tau pairs at a hadron collider.« less

Results on reuse of reclaimed shower water

NASA Technical Reports Server (NTRS)

Verostko, Charles E.; Garcia, Rafael; Pierson, Duane L.; Reysa, Richard P.; Irbe, Robert

1986-01-01

The Waste Water Recovery System that has been used in conjunction with a microgravity whole body shower to test a closed loop shower water reclamation system applicable to the NASA Space Station employs a Thermoelectric Integrated Hollow Fiber Membrane Evaporation Subsystem. Attention is given to the suitability of a Space Shuttle soap for such crew showers, the effects of shower water on the entire system, and the purification qualities of the recovered water. The chemical pretreatment of the shower water for microorganism control involved activated carbon, mixed ion exchange resin beds, and iodine bactericide dispensing units. The water was recycled five times, demonstrating the feasibility of reuse.

A tale of two modes: neutrino free-streaming in the early universe

NASA Astrophysics Data System (ADS)

Lancaster, Lachlan; Cyr-Racine, Francis-Yan; Knox, Lloyd; Pan, Zhen

2017-07-01

We present updated constraints on the free-streaming nature of cosmological neutrinos from cosmic microwave background (CMB) temperature and polarization power spectra, baryonic acoustic oscillation data, and distance ladder measurements of the Hubble constant. Specifically, we consider a Fermi-like four-fermion interaction between massless neutrinos, characterized by an effective coupling constant Geff, and resulting in a neutrino opacity dot tauνpropto Geff2 Tν5. Using a conservative flat prior on the parameter log10( Geff MeV2), we find a bimodal posterior distribution with two clearly separated regions of high probability. The first of these modes is consistent with the standard ΛCDM cosmology and corresponds to neutrinos decoupling at redshift zν,dec > 1.3×105, that is before the Fourier modes probed by the CMB damping tail enter the causal horizon. The other mode of the posterior, dubbed the "interacting neutrino mode", corresponds to neutrino decoupling occurring within a narrow redshift window centered around zν,dec~8300. This mode is characterized by a high value of the effective neutrino coupling constant, log10( Geff MeV2) = -1.72 ± 0.10 (68% C.L.), together with a lower value of the scalar spectral index and amplitude of fluctuations, and a higher value of the Hubble parameter. Using both a maximum likelihood analysis and the ratio of the two mode's Bayesian evidence, we find the interacting neutrino mode to be statistically disfavored compared to the standard ΛCDM cosmology, and determine this result to be largely driven by the low-l CMB temperature data. Interestingly, the addition of CMB polarization and direct Hubble constant measurements significantly raises the statistical significance of this secondary mode, indicating that new physics in the neutrino sector could help explain the difference between local measurements of H0, and those inferred from CMB data. A robust consequence of our results is that neutrinos must be free streaming long

Atmospheric Neutrinos in Soudan 2

NASA Astrophysics Data System (ADS)

Goodman, M.; Soudan 2 Collaboration

2001-08-01

Neutrino interactions recorded in a 5.1 fiducial kiloton-year exposure of the Soudan-2 iron tracking calorimeter are analyzed for effects of neutrino oscillations. Using contained single track and single shower events, we update our measurement of the atmospheric / ratio-of-ratios and find . Assuming this anomalously low R-value is the result of flavor disappearance viat o oscillation, we select samples of charged current events which offer good resolution, event-by-event, for Ä reconstruction. Oscillation-weighted Monte Carlo events are fitted to these data events using a ¾ function summed over bins of log´Ä µ. The region allowed in the (× Ò¾ ¾ , ¡Ñ¾) plane at 90% CL is obtained using the Feldman-Cousins procedure: 1 DETECTOR; DATA EXPOSURE The Soudan-2 experiment will soon (July 2001) be completing the taking of data using its fine-grained iron tracking calorimeter of total mass 963 tons. This detector images nonrelativistic as well as relativistic charged particles produced in atmospheric neutrino reactions. It has operated underground at a depth of 2100 meters-water-equivalent on level 27 of the Soudan Mine State Park in northern Minnesota. The calorimeter's modular design enabled data-taking to commence in April 1989 when the detector was one quarter of its full size; assembly of the detector was completed during 1993. Data-taking continued with 85% live time, even though dynamite blasting has been underway nearby for the MINOS cavern excavation since Summer 1999. The total data exposure will be 5.8fiducial kiloton-years (kTy). Results presented here are based upon a 5.1 kTy exposure. The tracking calorimeter operates as a slow-drift (0.6 cm/ s) time projection chamber. Its tracking elements are meterlong plastic drift tubes which are placed into the corruga-

The thickness of the shower disc as observed in showers produced by primaries above 10 (19)eV

NASA Technical Reports Server (NTRS)

Lawrence, M. A.; Watson, A. A.; West, A. A.

1985-01-01

The thickness of the shower disk has been measured in showers initiated by primaries of energy to 10 the 19th power eV using the large area water Cerenkov detectors of the Haverah Park array. Results are presented which (1) provide supporting evidence for the accuracy of analysis procedures in giant showers, (2) offer an evaluation of the mini-array technique for the detection of giant showers and (3) extend earlier work on developmental fluctuations above 10 to the 19th power eV.

MINIMAL PROSPECTS FOR RADIO DETECTION OF EXTENSIVE AIR SHOWERS IN THE ATMOSPHERE OF JUPITER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bray, J. D.; Nelles, A., E-mail: justin.bray@manchester.ac.uk

One possible approach for detecting ultra-high-energy cosmic rays and neutrinos is to search for radio emission from extensive air showers created when they interact in the atmosphere of Jupiter, effectively utilizing Jupiter as a particle detector. We investigate the potential of this approach. For searches with current or planned radio telescopes we find that the effective area for detection of cosmic rays is substantial (∼3 × 10{sup 7} km{sup 2}), but the acceptance angle is so small that the typical geometric aperture (∼10{sup 3} km{sup 2} sr) is less than that of existing terrestrial detectors, and cosmic rays also cannotmore » be detected below an extremely high threshold energy (∼10{sup 23} eV). The geometric aperture for neutrinos is slightly larger, and greater sensitivity can be achieved with a radio detector on a Jupiter-orbiting satellite, but in neither case is this sufficient to constitute a practical detection technique. Exploitation of the large surface area of Jupiter for detecting ultra-high-energy particles remains a long-term prospect that will require a different technique, such as orbital fluorescence detection.« less

Search for neutrinos from dark matter self-annihilations in the center of the Milky Way with 3 years of IceCube/DeepCore: IceCube Collaboration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aartsen, M. G.; Ackermann, M.; Adams, J.

Here, we present a search for a neutrino signal from dark matter self-annihilations in the Milky Way using the IceCube Neutrino Observatory (IceCube). In 1005 days of data we found no significant excess of neutrinos over the background of neutrinos produced in atmospheric air showers from cosmic ray interactions. We derive upper limits on the velocity averaged product of the dark matter self-annihilation cross section and the relative velocity of the dark matter particles < σ A v>. We then set the upper limits for dark matter particle candidate masses ranging from 10 GeV up to 1 TeV while considering annihilation throughmore » multiple channels. This work sets the most stringent limit on a neutrino signal from dark matter with mass between 10 and 100 GeV, with a limit of 1.18·10 -23cm 3s -1 for 100 GeV dark matter particles self-annihilating via τ + τ - to neutrinos (assuming the Navarro–Frenk–White dark matter halo profile).« less

Search for neutrinos from dark matter self-annihilations in the center of the Milky Way with 3 years of IceCube/DeepCore: IceCube Collaboration

DOE PAGES

Aartsen, M. G.; Ackermann, M.; Adams, J.; ...

2017-09-20

Here, we present a search for a neutrino signal from dark matter self-annihilations in the Milky Way using the IceCube Neutrino Observatory (IceCube). In 1005 days of data we found no significant excess of neutrinos over the background of neutrinos produced in atmospheric air showers from cosmic ray interactions. We derive upper limits on the velocity averaged product of the dark matter self-annihilation cross section and the relative velocity of the dark matter particles < σ A v>. We then set the upper limits for dark matter particle candidate masses ranging from 10 GeV up to 1 TeV while considering annihilation throughmore » multiple channels. This work sets the most stringent limit on a neutrino signal from dark matter with mass between 10 and 100 GeV, with a limit of 1.18·10 -23cm 3s -1 for 100 GeV dark matter particles self-annihilating via τ + τ - to neutrinos (assuming the Navarro–Frenk–White dark matter halo profile).« less

Pursuing a historical meteor shower

NASA Astrophysics Data System (ADS)

Watanabe, Jun-Ichi; Sato, Mikiya; Kasuga, Toshihiro

2006-11-01

The strong outburst of the Phoenicids was witnessed by people in a Japanese expedition ship, Soya, in 1956. After that, this meteor shower has never been observed at this activity level. Although its parent comet has not been strictly identified, the possible candidate was the comet D/1819W1 (Blanpain) which appeared only once in 1819. A newly discovered asteroid 2003WY25 becomes a clue to the mystery of this meteor shower. We introduce our result on the investigation of this meteor shower on the basis of the dust trail theory.

On the energy and baseline optimization to study effects related to the /δ-phase (CP-/T-violation) in neutrino oscillations at a neutrino factory

NASA Astrophysics Data System (ADS)

Bueno, A.; Campanelli, M.; Navas-Concha, S.; Rubbia, A.

2002-06-01

In this paper we discuss the detection of CP- and T-violation effects in the framework of a neutrino factory. We introduce three quantities, which are good discriminants for a non-vanishing complex phase ( δ) in the 3×3 neutrino mixing matrix: Δδ, ΔCP and ΔT. We find that these three discriminants (in vacuum) all scale with L/ Eν, where L is the baseline and Eν the neutrino energy. Matter effects modify the scaling, but these effects are large enough to spoil the sensitivity only for baselines larger than 5000 km. So, in the hypothesis of constant neutrino factory power (i.e., number of muons inversely proportional to muon energy), the sensitivity on the δ-phase is independent of the baseline chosen. Specially interesting is the direct measurement of T-violation from the "wrong-sign" electron channel (i.e., the ΔT discriminant), which involves a comparison of the νe→ νμ and νμ→ νe oscillation rates. However, the νμ→ νe measurement requires magnetic discrimination of the electron charge, experimentally very challenging in a neutrino detector. Since the direction of the electron curvature has to be estimated before the start of the electromagnetic shower, low-energy neutrino beams and hence short baselines, are preferred. In this paper we show, as an example, the exclusion regions in the Δm212- δ plane using the ΔCP and ΔT discriminants for two concrete cases keeping the same L/ Eν ratio (730 km/7.5 GeV and 2900 km/30 GeV). We obtain a similar excluded region provided that the electron detection efficiency is ˜20% and the charge confusion 0.1%. The Δm212 compatible with the LMA solar data can be tested with a flux of 5×10 21 muons. We compare these results with the fit of the visible energy distributions.

Expanding the reach of heavy neutrino searches at the LHC

NASA Astrophysics Data System (ADS)

Flórez, Andrés; Gui, Kaiwen; Gurrola, Alfredo; Patiño, Carlos; Restrepo, Diego

2018-03-01

The observation of neutrino oscillations establishes that neutrinos have non-zero mass and provides one of the more compelling arguments for physics beyond the standard model (SM) of particle physics. We present a feasibility study to search for hypothetical Majorana neutrinos (N) with TeV scale masses, predicted by extensions of the SM to explain the small but non-zero SM neutrino mass, using vector boson fusion (VBF) processes at the 13 TeV LHC. In the context of the minimal Type-I seesaw mechanism (mTISM), the VBF production cross-section of a lepton (ℓ) and associated heavy Majorana neutrino (Nℓ) surpasses that of the Drell-Yan process at approximately mNℓ = 1.4TeV. We consider second and third-generation heavy neutrino (Nμ or Nτ, where ℓ= muon (μ) or tau (τ) leptons) production through VBF processes, with subsequent Nμ and Nτ decays to a lepton and two jets, as benchmark cases to show the effectiveness of the VBF topology for Nℓ searches at the 13 TeV LHC. The requirement of a dilepton pair combined with four jets, two of which are identified as VBF jets with large separation in pseudorapidity and a TeV scale dijet mass, is effective at reducing the SM background. These criteria may provide expected exclusion bounds, at 95% confidence level, of mNℓ < 1.7 (2.4) TeV, assuming 100 (1000) fb-1 of 13 TeV data from the LHC and mixing |VℓNℓ|2 = 1. The use of the VBF topology to search for mNℓ increases the discovery reach at the LHC, with expected significances greater than 5σ (3σ) for Nℓ masses up to 1.7 (2.05) TeV using 1000fb-1 of 13 TeV data from the LHC.

Meteor Showers.

ERIC Educational Resources Information Center

Kronk, Gary W.

1988-01-01

Described are the history, formation, and observing techniques of meteors and comets. Provided are several pictures, diagrams, meteor organizations and publications, and meteor shower observation tables. (YP)

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology.

PubMed

Gratuze, Maud; Julien, Jacinthe; Petry, Franck R; Morin, Françoise; Planel, Emmanuel

2017-04-12

Abnormally hyperphosphorylated tau aggregated as intraneuronal neurofibrillary tangles is one of the two neuropathological hallmarks of Alzheimer's disease (AD). The majority of AD cases are sporadic with numerous environmental, biological and genetic risks factors. Interestingly, insulin dysfunction and hyperglycaemia are both risk factors for sporadic AD. However, how hyperglycaemia and insulin dysfunction affect tau pathology, is not well understood. In this study, we examined the effects of insulin deficiency on tau pathology in transgenic hTau mice by injecting different doses of streptozotocin (STZ), a toxin that destroys insulin-producing cells in the pancreas. One high dose of STZ resulted in marked diabetes, and five low doses led to a milder diabetes. Both groups exhibited brain tau hyperphosphorylation but no increased aggregation. Tau hyperphosphorylation correlated with inhibition of Protein Phosphatase 2A (PP2A), the main tau phosphatase. Interestingly, insulin injection 30 minutes before sacrifice partially restored tau phosphorylation to control levels in both STZ-injected groups. Our results confirm a link between insulin homeostasis and tau phosphorylation, which could explain, at least in part, a higher incidence of AD in diabetic patients.

Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption

PubMed Central

Jones, Emmalee M.; Dubey, Manish; Camp, Phillip J.; Vernon, Briana C.; Biernat, Jacek; Mandelkow, Eckhard; Majewski, Jaroslaw; Chi, Eva Y.

2012-01-01

The misfolding and aggregation of the intrinsically disordered, microtubule-associated tau protein into neurofibrillary tangles is implicated in the pathogenesis of Alzheimer's disease. However, the mechanisms of tau aggregation and toxicity remain unknown. Recent work has shown that lipid membrane can induce tau aggregation and that membrane permeabilization may serve as a pathway by which protein aggregates exert toxicity, suggesting that the plasma membrane may play dual roles in tau pathology. This prompted our investigation to assess tau's propensity to interact with membranes and to elucidate the mutually disruptive structural perturbations the interactions induce in both tau and the membrane. We show that although highly charged and soluble, the full-length tau (hTau40) is also highly surface active, selectively inserts into anionic DMPG lipid monolayers and induces membrane morphological changes. To resolve molecular-scale structural details of hTau40 associated with lipid membranes, X-ray and neutron scattering techniques are utilized. X-ray reflectivity indicates hTau40's presence underneath a DMPG monolayer and penetration into the lipid headgroups and tailgroups, whereas grazing incidence X-ray diffraction shows that hTau40 insertion disrupts lipid packing. Moreover, both air/water and DMPG lipid membrane interfaces induce the disordered hTau40 to partially adopt a more compact conformation with density similar to that of a folded protein. Neutron reflectivity shows that tau completely disrupts supported DMPG bilayers while leaving the neutral DPPC bilayer intact. Our results show that hTau40's strong interaction with anionic lipids induces tau structural compaction and membrane disruption, suggesting possible membrane-based mechanisms of tau aggregation and toxicity in neurodegenerative diseases. PMID:22401494

Occurrence of Legionella in UK household showers.

PubMed

Collins, Samuel; Stevenson, David; Bennett, Allan; Walker, Jimmy

2017-04-01

Household water systems have been proposed as a source of sporadic, community acquired Legionnaires' disease. Showers represent a frequently used aerosol generating device in the domestic setting yet little is known about the occurrence of Legionella spp. in these systems. This study has investigated the prevalence of Legionella spp. by culture and qPCR in UK household showers. Ninety nine showers from 82 separate properties in the South of England were sampled. Clinically relevant Legionella spp. were isolated by culture in 8% of shower water samples representing 6% of households. Legionella pneumophila sg1 ST59 was isolated from two showers in one property and air sampling demonstrated its presence in the aerosol state. A further 31% of showers were positive by Legionella spp. qPCR. By multi-variable binomial regression modelling Legionella spp. qPCR positivity was associated with the age of the property (p=0.02), the age of the shower (p=0.01) and the frequency of use (p=0.09). The concentration of Legionella spp. detected by qPCR was shown to decrease with increased frequency of use (p=0.04) and more frequent showerhead cleaning (p=0.05). There was no association between Legionella spp. qPCR positivity and the cold water supply or the showerhead material (p=0.65 and p=0.71, respectively). Household showers may be important reservoirs of clinically significant Legionella and should be considered in source investigations. Simple public health advice may help to mitigate the risk of Legionella exposure in the domestic shower environment. Crown Copyright © 2016. Published by Elsevier GmbH. All rights reserved.

C P -invariance violation at short-baseline experiments in 3 +1 neutrino scenarios

NASA Astrophysics Data System (ADS)

de Gouvêa, André; Kelly, Kevin J.; Kobach, Andrew

2015-03-01

New neutrino degrees of freedom allow for more sources of charge parity- (C P ) invariance violation (CPV). We explore the requirements for accessing C P -odd mixing parameters in the so-called 3 +1 scenario, where one assumes the existence of one extra, mostly sterile neutrino degree of freedom, heavier than the other three mass eigenstates. As a first step, we concentrate on the νe→νμ appearance channel in a hypothetical, upgraded version of the ν STORM proposal. We establish that the optimal baseline for CPV studies depends strongly on the value of Δ m142—the new mass-squared difference—and that the ability to observe CPV depends significantly on whether the experiment is performed at the optimal baseline. Even at the optimal baseline, it is very challenging to see CPV in 3 +1 scenarios if one considers only one appearance channel. Full exploration of CPV in short-baseline experiments will require precision measurements of tau appearance, a challenge significantly beyond what is currently being explored by the experimental neutrino community.

Neutrino Oscillations and the Sudbury Neutrino Observatory

NASA Astrophysics Data System (ADS)

Wark, David

2001-04-01

When the existence of the neutrino was almost apologetically first proposed by Wolfgang Pauli it was intended to explain the mysterious apparent absence of energy and momentum in beta decay. 70 years later the neutrino has indeed solved that mystery, but it has generated still more of its own. Are neutrinos massive? Is it possible to create a neutrino with its spin in the same direction as its momentum? What fraction of the mass of the Universe is made up of neutrinos? Are the flavour labels which we put on neutrinos, like electron and muon, really fixed or can they change? Why does no experiment see the predicted flux of neutrinos from the Sun? Why do there appear to be roughly equal numbers of muon and electron neutrinos created in our atmosphere, rather than the 2:1 ratio we would expect? Many of these questions were coupled when Bruno Pontecorvo first suggested that the shortfall in solar neutrino measurements were caused by neutrino oscillations - neutrinos spontaneously changing flavour as they travel from the Sun. 30 years later we still await definitive proof of that conjecture, and providing that proof is the reason for the Sudbury Neutrino Observatory. The talk will discuss the current state of neutrino oscillations studies, and show how the unique capabilities of the Sudbury Neutrino Observatory can provide definitive proof of whether neutrino oscillations are the long-sought answer to the solar neutrino problem.

Search for tau-neutrino interactions in the BEBC beam dump experiment

NASA Astrophysics Data System (ADS)

Talebzadeh, M.; Guy, J.; Venus, W.; Aderholz, M.; Barnham, K. W. J.; Bostock, P.; Clayton, E. F.; Cooper-Sarkar, A. M.; Faccini-Turluer, M. L.; Grässler, H.; Hultquist, K.; Hulth, P. O.; Kreutzmann, H.; Krstic, J.; Miller, D. B.; Mobayyen, M. M.; Myatt, G.; Nellen, B.; Parker, M. A.; Schmitz, N.; Sewell, S.; Simopoulou, E.; Vayaki, A.; Vignaud, D.; Wachsmuth, H.; Wittek, W.; Wünsch, B.; BEBC WA66 Collaboration

A novel and efficient kinematic method is used to estimate the number of ντ charged current interactions with Eν > 20 GeV in the BEBC beam dump experiment. The result, -14±12 ντ events, is consistent with zero. The ratio of D s to D meson production in 400 GeV proton interactions in copper is estimated to be below 0.65 at 90% c.l. The oscillation probability P( νe→ ντ) averaged over the electron-(anti)neutrino spectrum is found to be below 18%. The hypothesis that νe and ντ are identical is excluded by about 6 standard deviations. A remarkable event is described: it contains a muon, a high pT photon and a high pT hadron.

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

PubMed Central

Boluda, Susana; Iba, Michiyo; Zhang, Bin; Raible, Kevin M.; Lee, Virginia M-Y.; Trojanowski, John Q.

2015-01-01

Filamentous tau pathologies are hallmark lesions of several neurodegenerative tauopathies including Alzheimer’s disease (AD) and corticobasal degeneration (CBD) which show cell type-specific and topographically distinct tau inclusions. Growing evidence supports templated transmission of tauopathies through functionally interconnected neuroanatomical pathways suggesting that different self-propagating strains of pathological tau could account for the diverse manifestations of neurodegenerative tauopathies. Here, we describe the rapid and distinct cell type-specific spread of pathological tau following intracerebral injections of CBD or AD brain extracts enriched in pathological tau (designated CBD-Tau and AD-Tau, respectively) in young human mutant P301S tau transgenic (Tg) mice (line PS19) ~6–9 months before they show onset of mutant tau transgene-induced tau pathology. At 1 month post-injection of CBD-Tau, tau inclusions developed predominantly in oligodendrocytes of the fimbria and white matter near the injection sites with infrequent intraneuronal tau aggregates. In contrast, injections of AD-Tau in young PS19 mice induced tau pathology predominantly in neuronal perikarya with little or no oligodendrocyte involvement 1 month post-injection. With longer post-injection survival intervals of up to 6 months, CBD-Tau- and AD-Tau-induced tau pathology spread to different brain regions distant from the injection sites while maintaining the cell type-specific pattern noted above. Finally, CA3 neuron loss was detected 3 months post-injection of AD-Tau but not CBD-Tau. Thus, AD-Tau and CBD-Tau represent specific pathological tau strains that spread differentially and may underlie distinct clinical and pathological features of these two tauopathies. Hence, these strains could become targets to develop disease-modifying therapies for CBD and AD. PMID:25534024

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis.

PubMed

Hu, Wen; Wu, Feng; Zhang, Yanchong; Gong, Cheng-Xin; Iqbal, Khalid; Liu, Fei

2017-01-01

Microtubule-associated protein tau is hyperphosphorylated and aggregated in affected neurons in Alzheimer disease (AD) brains. The tau pathology starts from the entorhinal cortex (EC), spreads to the hippocampus and frontal and temporal cortices, and finally to all isocortex areas, but the cerebellum is spared from tau lesions. The molecular basis of differential vulnerability of different brain regions to tau pathology is not understood. In the present study, we analyzed brain regional expressions of tau and tau pathology-related proteins. We found that tau was hyperphosphorylated at multiple sites in the frontal cortex (FC), but not in the cerebellum, from AD brain. The level of tau expression in the cerebellum was about 1/4 of that seen in the frontal and temporal cortices in human brain. In the rat brain, the expression level of tau with three microtubule-binding repeats (3R-tau) was comparable in the hippocampus, EC, FC, parietal-temporal cortex (PTC), occipital-temporal cortex (OTC), striatum, thalamus, olfactory bulb (OB) and cerebellum. However, the expression level of 4R-tau was the highest in the EC and the lowest in the cerebellum. Tau phosphatases, kinases, microtubule-related proteins and other tau pathology-related proteins were also expressed in a region-specific manner in the rat brain. These results suggest that higher levels of tau and tau kinases in the EC and low levels of these proteins in the cerebellum may accounts for the vulnerability and resistance of these representative brain regions to the development of tau pathology, respectively. The present study provides the regional expression profiles of tau and tau pathology-related proteins in the brain, which may help understand the brain regional vulnerability to tau pathology in neurodegenerative tauopathies.

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.

PubMed

Nobuhara, Chloe K; DeVos, Sarah L; Commins, Caitlin; Wegmann, Susanne; Moore, Benjamin D; Roe, Allyson D; Costantino, Isabel; Frosch, Matthew P; Pitstick, Rose; Carlson, George A; Hock, Christoph; Nitsch, Roger M; Montrasio, Fabio; Grimm, Jan; Cheung, Anne E; Dunah, Anthone W; Wittmann, Marion; Bussiere, Thierry; Weinreb, Paul H; Hyman, Bradley T; Takeda, Shuko

2017-06-01

The clinical progression of Alzheimer disease (AD) is associated with the accumulation of tau neurofibrillary tangles, which may spread throughout the cortex by interneuronal tau transfer. If so, targeting extracellular tau species may slow the spreading of tau pathology and possibly cognitive decline. To identify suitable target epitopes, we tested the effects of a panel of tau antibodies on neuronal uptake and aggregation in vitro. Immunodepletion was performed on brain extract from tau-transgenic mice and postmortem AD brain and added to a sensitive fluorescence resonance energy transfer-based tau uptake assay to assess blocking efficacy. The antibodies reduced tau uptake in an epitope-dependent manner: N-terminal (Tau13) and middomain (6C5 and HT7) antibodies successfully prevented uptake of tau species, whereas the distal C-terminal-specific antibody (Tau46) had little effect. Phosphorylation-dependent (40E8 and p396) and C-terminal half (4E4) tau antibodies also reduced tau uptake despite removing less total tau by immunodepletion, suggesting specific interactions with species involved in uptake. Among the seven antibodies evaluated, 6C5 most efficiently blocked uptake and subsequent aggregation. More important, 6C5 also blocked neuron-to-neuron spreading of tau in a unique three-chamber microfluidic device. Furthermore, 6C5 slowed down the progression of tau aggregation even after uptake had begun. Our results imply that not all antibodies/epitopes are equally robust in terms of blocking tau uptake of human AD-derived tau species. Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology

PubMed Central

Gratuze, Maud; Julien, Jacinthe; Petry, Franck R.; Morin, Françoise; Planel, Emmanuel

2017-01-01

Abnormally hyperphosphorylated tau aggregated as intraneuronal neurofibrillary tangles is one of the two neuropathological hallmarks of Alzheimer’s disease (AD). The majority of AD cases are sporadic with numerous environmental, biological and genetic risks factors. Interestingly, insulin dysfunction and hyperglycaemia are both risk factors for sporadic AD. However, how hyperglycaemia and insulin dysfunction affect tau pathology, is not well understood. In this study, we examined the effects of insulin deficiency on tau pathology in transgenic hTau mice by injecting different doses of streptozotocin (STZ), a toxin that destroys insulin-producing cells in the pancreas. One high dose of STZ resulted in marked diabetes, and five low doses led to a milder diabetes. Both groups exhibited brain tau hyperphosphorylation but no increased aggregation. Tau hyperphosphorylation correlated with inhibition of Protein Phosphatase 2A (PP2A), the main tau phosphatase. Interestingly, insulin injection 30 minutes before sacrifice partially restored tau phosphorylation to control levels in both STZ-injected groups. Our results confirm a link between insulin homeostasis and tau phosphorylation, which could explain, at least in part, a higher incidence of AD in diabetic patients. PMID:28402338

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

PubMed Central

Maphis, Nicole; Xu, Guixiang; Kokiko-Cochran, Olga N.; Jiang, Shanya; Cardona, Astrid; Ransohoff, Richard M.; Lamb, Bruce T.

2015-01-01

Pathological aggregation of tau is a hallmark of Alzheimer’s disease and related tauopathies. We have previously shown that the deficiency of the microglial fractalkine receptor (CX3CR1) led to the acceleration of tau pathology and memory impairment in an hTau mouse model of tauopathy. Here, we show that microglia drive tau pathology in a cell-autonomous manner. First, tau hyperphosphorylation and aggregation occur as early as 2 months of age in hTauCx3cr1−/− mice. Second, CD45+ microglial activation correlates with the spatial memory deficit and spread of tau pathology in the anatomically connected regions of the hippocampus. Third, adoptive transfer of purified microglia derived from hTauCx3cr1−/− mice induces tau hyperphosphorylation within the brains of non-transgenic recipient mice. Finally, inclusion of interleukin 1 receptor antagonist (Kineret®) in the adoptive transfer inoculum significantly reduces microglia-induced tau pathology. Together, our results suggest that reactive microglia are sufficient to drive tau pathology and correlate with the spread of pathological tau in the brain. PMID:25833819

Experimental evidence for the sensitivity of the air-shower radio signal to the longitudinal shower development

NASA Astrophysics Data System (ADS)

Apel, W. D.; Arteaga, J. C.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Buchholz, P.; Cantoni, E.; Chiavassa, A.; Daumiller, K.; de Souza, V.; Di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Finger, M.; Fuchs, B.; Fuhrmann, D.; Gemmeke, H.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Krömer, O.; Kuijpers, J.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Melissas, M.; Morello, C.; Oehlschläger, J.; Palmieri, N.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Rühle, C.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Schröder, F. G.; Sima, O.; Toma, G.; Trinchero, G. C.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.

2012-04-01

We observe a correlation between the slope of radio lateral distributions and the mean muon pseudorapidity of 59 individual cosmic-ray-air-shower events. The radio lateral distributions are measured with LOPES, a digital radio interferometer colocated with the multidetector-air-shower array KASCADE-Grande, which includes a muon-tracking detector. The result proves experimentally that radio measurements are sensitive to the longitudinal development of cosmic-ray air showers. This is one of the main prerequisites for using radio arrays for ultra-high-energy particle physics and astrophysics.

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.

PubMed

Song, Lixin; Lu, Sherry X; Ouyang, Xuesong; Melchor, Jerry; Lee, Julie; Terracina, Giuseppe; Wang, Xiaohai; Hyde, Lynn; Hess, J Fred; Parker, Eric M; Zhang, Lili

2015-03-26

Microtubule associated protein tau is the major component of the neurofibrillary tangles (NFTs) found in the brains of patients with Alzheimer's disease and several other neurodegenerative diseases. Tau mutations are associated with frontotemperal dementia with parkinsonism on chromosome 17 (FTDP-17). rTg4510 mice overexpress human tau carrying the P301L FTDP-17 mutation and develop robust NFT-like pathology at 4-5 months of age. The current study is aimed at characterizing the rTg4510 mice to better understand the genesis of tau pathology and to better enable the use of this model in drug discovery efforts targeting tau pathology. Using a panel of immunoassays, we analyzed the age-dependent formation of pathological tau in rTg4510 mice and our data revealed a steady age-dependent accumulation of pathological tau in the insoluble fraction of brain homogenates. The pathological tau was associated with multiple post-translational modifications including aggregation, phosphorylation at a wide variety of sites, acetylation, ubiquitination and nitration. The change of most tau species reached statistical significance at the age of 16 weeks. There was a strong correlation between the different post-translationally modified tau species in this heterogeneous pool of pathological tau. Total tau in the cerebrospinal fluid (CSF) displayed a multiphasic temporal profile distinct from the steady accumulation of pathological tau in the brain. Female rTg4510 mice displayed significantly more aggressive accumulation of pathological tau in the brain and elevation of total tau in CSF than their male littermates. The immunoassays described here were used to generate the most comprehensive description of the changes in various tau species across the lifespan of the rTg4510 mouse model. The data indicate that development of tauopathy in rTg4510 mice involves the accumulation of a pool of pathological tau that carries multiple post-translational modifications, a process that can be

The radio emission pattern of air showers as measured with LOFAR—a tool for the reconstruction of the energy and the shower maximum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelles, A.; Corstanje, A.; Enriquez, J.E.

2015-05-01

The pattern of the radio emission of air showers is finely sampled with the Low-Frequency ARray (LOFAR). A set of 382 measured air showers is used to test a fast, analytic parameterization of the distribution of pulse powers. Using this parameterization we are able to reconstruct the shower axis and give estimators for the energy of the air shower as well as the distance to the shower maximum.

Effective Majorana mass matrix from tau and pseudoscalar meson lepton number violating decays

NASA Astrophysics Data System (ADS)

Abada, Asmaa; De Romeri, Valentina; Lucente, Michele; Teixeira, Ana M.; Toma, Takashi

2018-02-01

An observation of any lepton number violating process will undoubtedly point towards the existence of new physics and indirectly to the clear Majorana nature of the exchanged fermion. In this work, we explore the potential of a minimal extension of the Standard Model via heavy sterile fermions with masses in the [0.1 - 10] GeV range concerning an extensive array of "neutrinoless" meson and tau decay processes. We assume that the Majorana neutrinos are produced on-shell, and focus on three-body decays. We conduct an update on the bounds on the active-sterile mixing elements, |{U}_{ℓ }{{}{_{α}}}_4{U}_{ℓ }{{}{_{β}}}_4| , taking into account the most recent experimental bounds (and constraints) and new theoretical inputs, as well as the effects of a finite detector, imposing that the heavy neutrino decay within the detector. This allows to establish up-to-date comprehensive constraints on the sterile fermion parameter space. Our results suggest that the branching fractions of several decays are close to current sensitivities (likely within reach of future facilities), some being already in conflict with current data (as is the case of K + → ℓ α + ℓ β + π -, and τ - → μ +π-π-). We use these processes to extract constraints on all entries of an enlarged definition of a 3 × 3 "effective" Majorana neutrino mass matrix m ν αβ .

Neutrino masses, neutrino oscillations, and cosmological implications

NASA Technical Reports Server (NTRS)

Stecker, F. W.

1982-01-01

Theoretical concepts and motivations for considering neutrinos having finite masses are discussed and the experimental situation on searches for neutrino masses and oscillations is summarized. The solar neutrino problem, reactor, deep mine and accelerator data, tri decay experiments and double beta-decay data are considered and cosmological implications and astrophysical data relating to neutrino masses are reviewed. The neutrino oscillation solution to the solar neutrino problem, the missing mass problem in galaxy halos and galaxy cluster galaxy formation and clustering, and radiative neutrino decay and the cosmic ultraviolet background radiation are examined.

49 CFR 228.321 - Showering facilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... and cold running potable water must be provided for showering purposes. The water supplied to a shower... provided with hot and cold water feeding a common discharge line. (3) Unless otherwise provided by a...

49 CFR 228.321 - Showering facilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... provided with hot and cold water feeding a common discharge line. (3) Unless otherwise provided by a... and cold running potable water must be provided for showering purposes. The water supplied to a shower...

49 CFR 228.321 - Showering facilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... provided with hot and cold water feeding a common discharge line. (3) Unless otherwise provided by a... and cold running potable water must be provided for showering purposes. The water supplied to a shower...

Testing the Effectiveness of Therapeutic Showering in Labor.

PubMed

Stark, Mary Ann

: Therapeutic showering is a holistic nursing intervention that is often available and supports physiologic labor. The purpose of this study was to compare the effectiveness of therapeutic showering with usual care during active labor. Research questions were as follows: Are there significant differences between women who showered 30 minutes during active labor and those who received usual labor care in anxiety, tension, relaxation, pain, discomfort, and coping? Is there a difference in use of obstetric interventions between groups? A convenience sample of healthy low-risk women in active labor was recruited (N = 32). A pretest posttest control group repeated-measures design was used. Participants were randomized to treatment group (n = 17), who showered for 30 minutes, or to control group (n = 14) who received usual labor care. Women evaluated pain, discomfort, anxiety, tension, coping, and relaxation at enrollment, again 15 minutes after entering the shower or receiving usual care, then again 30 minutes after entering the shower or receiving usual care. Chart reviews after delivery recorded obstetric interventions. The showering group had statistically significant decreases in pain, discomfort, anxiety and tension, and significant increase in relaxation. There were no differences in use of obstetric interventions. Therapeutic showering was effective in reducing pain, discomfort, anxiety, and tension while improving relaxation and supporting labor in this sample.

Activity and observability of meteor showers throughout the year

NASA Astrophysics Data System (ADS)

Zimnikoval, Peter

2014-02-01

Diagrams on the poster present the activity periods of meteor showers as well as the rising and setting times of meteor shower radiants. Plotted are sunrises, sunsets and the period of twilight. It was constructed according to data from the IMO Meteor Shower Working List. More active showers are displayed in red and less active showers in green. The diagrams are calculated for geographic latitudes of 40° N, 0° and 40° S. The time scale is given as local time at the relevant zonal meridian and supplemented by local daylight saving time. The diagrams contain rounded values of solar longitude J2000. The star chart shows the radiant positions and drift of IMO meteor showers while the other diagrams display shower activity and date of maximum.

DOPA Decarboxylase Modulates Tau Toxicity.

PubMed

Kow, Rebecca L; Sikkema, Carl; Wheeler, Jeanna M; Wilkinson, Charles W; Kraemer, Brian C

2018-03-01

The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D 2 -family dopamine receptors ameliorated tauopathy in multiple models including a Caenorhabditis elegans model of tauopathy. To better understand how loss of D 2 -family dopamine receptors can ameliorate tau toxicity, we screened a collection of C. elegans mutations in dopamine-related genes (n = 45) for changes in tau transgene-induced behavioral defects. These included many genes responsible for dopamine synthesis, metabolism, and signaling downstream of the D 2 receptors. We identified one dopamine synthesis gene, DOPA decarboxylase (DDC), as a suppressor of tau toxicity in tau transgenic worms. Loss of the C. elegans DDC gene, bas-1, ameliorated the behavioral deficits of tau transgenic worms, reduced phosphorylated and detergent-insoluble tau accumulation, and reduced tau-mediated neuron loss. Loss of function in other genes in the dopamine and serotonin synthesis pathways did not alter tau-induced toxicity; however, their function is required for the suppression of tau toxicity by bas-1. Additional loss of D 2 -family dopamine receptors did not synergize with bas-1 suppression of tauopathy phenotypes. Loss of the DDC bas-1 reduced tau-induced toxicity in a C. elegans model of tauopathy, while loss of no other dopamine or serotonin synthesis genes tested had this effect. Because loss of activity upstream of DDC could reduce suppression of tau by DDC, this suggests the possibility that loss of DDC suppresses tau via the combined accumulation of dopamine precursor levodopa and serotonin precursor 5-hydroxytryptophan. Published by Elsevier Inc.

Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation.

PubMed

Wei, Yu-Ping; Ye, Jin-Wang; Wang, Xiong; Zhu, Li-Ping; Hu, Qing-Hua; Wang, Qun; Ke, Dan; Tian, Qing; Wang, Jian-Zhi

2018-04-01

Hyperphosphorylated tau is the major protein component of neurofibrillary tangles in the brains of patients with Alzheimer's disease (AD). However, the mechanism underlying tau hyperphosphorylation is not fully understood. Here, we demonstrated that exogenously expressed wild-type human tau40 was detectable in the phosphorylated form at multiple AD-associated sites in cytoplasmic and nuclear fractions from HEK293 cells. Among these sites, tau phosphorylated at Thr205 and Ser214 was almost exclusively found in the nuclear fraction at the conditions used in the present study. With the intracellular tau accumulation, the Ca 2+ concentration was significantly increased in both cytoplasmic and nuclear fractions. Further studies using site-specific mutagenesis and pharmacological treatment demonstrated that phosphorylation of tau at Thr205 increased nuclear Ca 2+ concentration with a simultaneous increase in the phosphorylation of Ca 2+ /calmodulin-dependent protein kinase IV (CaMKIV) at Ser196. On the other hand, phosphorylation of tau at Ser214 did not significantly change the nuclear Ca 2+ /CaMKIV signaling. Finally, expressing calmodulin-binding protein-4 that disrupts formation of the Ca 2+ /calmodulin complex abolished the okadaic acid-induced tau hyperphosphorylation in the nuclear fraction. We conclude that the intracellular accumulation of phosphorylated tau, as detected in the brains of AD patients, can trigger nuclear Ca 2+ /CaMKIV signaling, which in turn aggravates tau hyperphosphorylation. Our findings provide new insights for tauopathies: hyperphosphorylation of intracellular tau and an increased Ca 2+ concentration may induce a self-perpetuating harmful loop to promote neurodegeneration.

Collective neutrino oscillations and neutrino wave packets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akhmedov, Evgeny; Lindner, Manfred; Kopp, Joachim, E-mail: akhmedov@mpi-hd.mpg.de, E-mail: jkopp@uni-mainz.de, E-mail: lindner@mpi-hd.mpg.de

Effects of decoherence by wave packet separation on collective neutrino oscillations in dense neutrino gases are considered. We estimate the length of the wave packets of neutrinos produced in core collapse supernovae and the expected neutrino coherence length, and then proceed to consider the decoherence effects within the density matrix formalism of neutrino flavour transitions. First, we demonstrate that for neutrino oscillations in vacuum the decoherence effects are described by a damping term in the equation of motion of the density matrix of a neutrino as a whole (as contrasted to that of the fixed-momentum components of the neutrino densitymore » matrix). Next, we consider neutrino oscillations in ordinary matter and dense neutrino backgrounds, both in the adiabatic and non-adiabatic regimes. In the latter case we study two specific models of adiabaticity violation—one with short-term and another with extended non-adiabaticity. It is demonstrated that, while in the adiabatic case a damping term is present in the equation of motion of the neutrino density matrix (just like in the vacuum oscillation case), no such term in general appears in the non-adiabatic regime.« less

Solar neutrino detectors as sterile neutrino hunters

NASA Astrophysics Data System (ADS)

Pallavicini, Marco; Borexino-SOX Collaboration; Agostini, M.; Altenmüller, K.; Appel, S.; Atroshchenko, V.; Bellini, G.; Benziger, J.; Berton, N.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Carlini, M.; Cavalcante, P.; Chepurnov, A.; Choi, K.; Cloué, O.; Cribier, M.; D'Angelo, D.; Davini, S.; Derbin, A.; Di Noto, L.; Drachnev, I.; Durero, M.; Etenko, A.; Farinon, S.; Fischer, V.; Fomenko, K.; Franco, D.; Gabriele, F.; Gaffiot, J.; Galbiati, C.; Gschwender, M.; Ghiano, C.; Giammarchi, M.; Goeger-Neff, M.; Goretti, A.; Gromov, M.; Hagner, C.; Houdy, Th.; Hungerford, E.; Ianni, Aldo; Ianni, Andrea; Jany, A.; Jedrzejczak, K.; Jeschke, D.; Jonquères, N.; Kobychev, V.; Korablev, D.; Korga, G.; Kornoukhov, V.; Kryn, D.; Lachenmaier, T.; Lasserre, T.; Laubenstein, M.; Lehnert, B.; Link, J.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, I.; Manecki, S.; Maneschg, W.; Marcocci, S.; Maricic, J.; Mention, G.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Montuschi, M.; Mosteiro, P.; Muratova, V.; Musenich, R.; Neumair, B.; Oberauer, L.; Ortica, F.; Papp, L.; Pocar, A.; Ranucci, G.; Razeto, A.; Re, A.; Reinert, Y.; Romani, A.; Roncin, R.; Rossi, N.; Schönert, S.; Scola, L.; Semenov, D.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Thurn, J.; Toropova, M.; Unzhakov, E.; Veyssière, C.; Vishneva, A.; Vivier, M.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Weinz, S.; Winter, J.; Wojcik, M.; Wurm, M.; Yokley, Z.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.

2017-09-01

The large size and the very low radioactive background of solar neutrino detectors such as Borexino at the Gran Sasso Laboratory in Italy offer a unique opportunity to probe the existence of neutrino oscillations into new sterile components by means of carefully designed and well calibrated anti-neutrino and neutrino artificial sources. In this paper we briefly summarise the key elements of the SOX experiment, a program for the search of sterile neutrinos (and other short distance effects) by means of a 144Ce-144Pr anti-neutrino source and, possibly in the medium term future, with a 51Cr neutrino source.

Shower disc sampling and the angular resolution of gamma-ray shower detectors

NASA Technical Reports Server (NTRS)

Lambert, A.; Lloyd-Evans, J.

1985-01-01

As part of the design study for the new UHE gamma ray detector being constsructed at Haverah Park, a series of experiments using scintillators operated side-by-side in 10 to the 15th power eV air showers are undertaken. Investigation of the rms sampling fluctuations in the shower disc arrival time yields an upper limit to the intrinsic sampling uncertainty, sigma sub rms = (1.1 + or - 0.1)ns, implying an angular resolution capability 1 deg for an inter-detector spacing of approximately 25 m.

Meteor Shower Identification and Characterization with Python

NASA Technical Reports Server (NTRS)

Moorhead, Althea

2015-01-01

The short development time associated with Python and the number of astronomical packages available have led to increased usage within NASA. The Meteoroid Environment Office in particular uses the Python language for a number of applications, including daily meteor shower activity reporting, searches for potential parent bodies of meteor showers, and short dynamical simulations. We present our development of a meteor shower identification code that identifies statistically significant groups of meteors on similar orbits. This code overcomes several challenging characteristics of meteor showers such as drastic differences in uncertainties between meteors and between the orbital elements of a single meteor, and the variation of shower characteristics such as duration with age or planetary perturbations. This code has been proven to successfully and quickly identify unusual meteor activity such as the 2014 kappa Cygnid outburst. We present our algorithm along with these successes and discuss our plans for further code development.

Simulation of radiation energy release in air showers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glaser, Christian; Erdmann, Martin; Hörandel, Jörg R.

2016-09-01

A simulation study of the energy released by extensive air showers in the form of MHz radiation is performed using the CoREAS simulation code. We develop an efficient method to extract this radiation energy from air-shower simulations. We determine the longitudinal profile of the radiation energy release and compare it to the longitudinal profile of the energy deposit by the electromagnetic component of the air shower. We find that the radiation energy corrected for the geometric dependence of the geomagnetic emission scales quadratically with the energy in the electromagnetic component of the air shower with a second-order dependence on themore » atmospheric density at the position of the maximum shower development X {sub max}. In a measurement where X {sub max} is not accessible, this second order dependence can be approximated using the zenith angle of the incoming direction of the air shower with only a minor loss in accuracy. Our method results in an intrinsic uncertainty of 4% in the determination of the energy in the electromagnetic air-shower component, which is well below current experimental uncertainties.« less

Molecular Analysis of Shower Curtain Biofilm Microbes

PubMed Central

Kelley, Scott T.; Theisen, Ulrike; Angenent, Largus T.; Amand, Allison St.; Pace, Norman R.

2004-01-01

Households provide environments that encourage the formation of microbial communities, often as biofilms. Such biofilms constitute potential reservoirs for pathogens, particularly for immune-compromised individuals. One household environment that potentially accumulates microbial biofilms is that provided by vinyl shower curtains. Over time, vinyl shower curtains accumulate films, commonly referred to as “soap scum,” which microscopy reveals are constituted of lush microbial biofilms. To determine the kinds of microbes that constitute shower curtain biofilms and thereby to identify potential opportunistic pathogens, we conducted an analysis of rRNA genes obtained by PCR from four vinyl shower curtains from different households. Each of the shower curtain communities was highly complex. No sequence was identical to one in the databases, and no identical sequences were encountered in the different communities. However, the sequences generally represented similar phylogenetic kinds of organisms. Particularly abundant sequences represented members of the α-group of proteobacteria, mainly Sphingomonas spp. and Methylobacterium spp. Both of these genera are known to include opportunistic pathogens, and several of the sequences obtained from the environmental DNA samples were closely related to known pathogens. Such organisms have also been linked to biofilm formation associated with water reservoirs and conduits. In addition, the study detected many other kinds of organisms at lower abundances. These results show that shower curtains are a potential source of opportunistic pathogens associated with biofilms. Frequent cleaning or disposal of shower curtains is indicated, particularly in households with immune-compromised individuals. PMID:15240300

THE RETURN OF THE ANDROMEDIDS METEOR SHOWER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiegert, Paul A.; Brown, Peter G.; Weryk, Robert J.

2013-03-15

The Andromedid meteor shower underwent spectacular outbursts in 1872 and 1885, producing thousands of visual meteors per hour and described as ''stars fell like rain'' in Chinese records of the time. The shower originates from comet 3D/Biela whose disintegration in the mid-1800's is linked to the outbursts, but the shower has been weak or absent since the late 19th century. This shower returned in 2011 December with a zenithal hourly rate of approximately 50, the strongest return in over a hundred years. Some 122 probable Andromedid orbits were detected by the Canadian Meteor Orbit Radar while one possible brighter Andromedidmore » member was detected by the Southern Ontario Meteor Network and several single station possible Andromedids by the Canadian Automated Meteor Observatory. The shower outburst occurred during 2011 December 3-5. The radiant at R.A. +18 Degree-Sign and decl. +56 Degree-Sign is typical of the ''classical'' Andromedids of the early 1800s, whose radiant was actually in Cassiopeia. Numerical simulations of the shower were necessary to identify it with the Andromedids, as the observed radiant differs markedly from the current radiant associated with that shower. The shower's orbital elements indicate that the material involved was released before 3D/Biela's breakup prior to 1846. The observed shower in 2011 had a slow geocentric speed (V{sub G} = 16 km s{sup -1}) and was comprised of small particles: the mean measured mass from the radar is {approx}5 Multiplication-Sign 10{sup -7} kg, corresponding to radii of 0.5 mm at a bulk density of 1000 kg m{sup -3}. Numerical simulations of the parent comet indicate that the meteoroids of the 2011 return of the Andromedids shower were primarily ejected during 3D/Biela's 1649 perihelion passage. The orbital characteristics, radiant, and timing as well as the absence of large particles in the streamlet are all broadly consistent with simulations. However, simulations of the 1649 perihelion passage

Analysis of inclined showers measured with LOPES

NASA Astrophysics Data System (ADS)

Lopes Collaboration; Saftoiu, A.; Apel, W. D.; Arteaga, J. C.; Asch, T.; Auffenberg, J.; Badea, F.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Brüggemann, M.; Buchholz, P.; Buitink, S.; Cantoni, E.; Chiavassa, A.; Cossavella, F.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Finger, M.; Fuhrmann, D.; Gemmeke, H.; Ghia, P. L.; Glasstetter, R.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Kickelbick, D.; Kolotaev, Y.; Krömer, O.; Kuijpers, J.; Lafebre, S.; Łuczak, P.; Mathes, H. J.; Mayer, H. J.; Milke, J.; Mitrica, B.; Morello, C.; Navarra, G.; Nehls, S.; Nigl, A.; Oehlschläger, J.; Over, S.; Petcu, M.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Schieler, H.; Schmidt, A.; Schröder, F.; Sima, O.; Singh, K.; Stümpert, M.; Toma, G.; Trinchero, G. C.; Ulrich, H.; Walkowiak, W.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.; LOPES Collaboration

2009-06-01

In the present study, we analyze the radio signal from inclined air showers recorded by LOPES-30 in coincidence with KASCADE-Grande. LOPES-30 consists of 30 East-West oriented digital antennas, which are amplitude calibrated by an external source. Radio emission from air showers is considered a geomagnetic effect. Inclined events provide a larger range of values for geomagnetic angle (angle between shower axis and geomagnetic field direction) than vertical showers and thus more information on the emission processes can be gathered. In order to have the geometry of the air shower we use the reconstruction provided by the KASCADE-Grande particle detectors array. Analyzing events observed by both LOPES and the extended part of the KASCADE array, Grande, gives the possibility to test in particular the capability and efficiency of radio detection of more distant events. The results are compared with a previous analysis of inclined events recorded by the initial 10 antenna set-up, LOPES-10, in coincidence with the Grande array.

Meteor showers associated with 2003EH1

NASA Astrophysics Data System (ADS)

Babadzhanov, P. B.; Williams, I. P.; Kokhirova, G. I.

2008-06-01

Using the Everhart RADAU19 numerical integration method, the orbital evolution of the near-Earth asteroid 2003EH1 is investigated. This asteroid belongs to the Amor group and is moving on a comet-like orbit. The integrations are performed over one cycle of variation of the perihelion argument ω. Over such a cycle, the orbit intersect that of the Earth at eight different values of ω. The orbital parameters are different at each of these intersections and so a meteoroid stream surrounding such an orbit can produce eight different meteor showers, one at each crossing. The geocentric radiants and velocities of the eight theoretical meteor showers associated with these crossing points are determined. Using published data, observed meteor showers are identified with each of the theoretically predicted showers. The character of the orbit and the existence of observed meteor showers associated with 2003EH1 confirm the supposition that this object is an extinct comet.

Search for the lepton-flavor-violating leptonic B(0)-->mu(+/-)tau(-/+) and B(0)-->e(+/-)tau(-/+).

PubMed

Bornheim, A; Lipeles, E; Pappas, S P; Weinstein, A J; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Rosner, J L; Ryd, A; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Sun, W M; Thayer, J G; Urner, D; Wilksen, T; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Wiss, J; Edwards, K W; Besson, D; Gao, K Y; Gong, D T; Kubota, Y; Li, S Z; Poling, R; Scott, A W; Smith, A; Stepaniak, C J; Urheim, J; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Arms, K; Gan, K K; Severini, H; Skubic, P; Asner, D M; Dytman, S A; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shibata, E I; Shipsey, I P J; Adams, G S; Chasse, M; Cummings, J P; Danko, I; Napolitano, J; Cronin-Hennessy, D; Park, C S; Park, W; Thayer, J B; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Stroynowski, R; Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dambasuren, E; Dorjkhaidav, O; Menaa, N; Mountain, R; Muramatsu, H; Nandakumar, R; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Mahmood, A H; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M

2004-12-10

We have searched a sample of 9.6 x 10(6) BB events for the lepton-flavor-violating leptonic B decays, B(0)-->mu(+/-)tau(-/+) and B(0)-->e(+/-)tau(-/+). The tau lepton was detected through the decay modes tau-->lnunu(-) , where l=e, mu. There is no indication of a signal, and we obtain the 90% confidence level upper limits B(B(0)-->mu(+/-)tau(-/+))<3.8 x 10(-5) and B(B(0)-->e(+/-)tau(-/+))<1.3 x 10(-4).

Saving water in showers

NASA Astrophysics Data System (ADS)

Alkhaddar, R. A.; Phipps, D.; Morgan, R.; Karci, B.; Hordesseux, J.

2007-07-01

This project is part of a programme aimed at reducing water consumption. Power showers are water inefficient, but in order to persuade the user to accept a lower water use it will be necessary to sustain the "shower experience" to maintain user satisfaction. Previous work has indicated that users' requirements include temperature stability, adequate water volume and distribution, and skin pressure, all of which are substantially controlled by the showerhead. In the present phase of the project several commercially available domestic showerheads have been examined to determine pressure-volume characteristics, radial spray distributions at different flow rates, direct and indirect measures of "skin pressure" and measurements of vertical temperature profiles. Part of the practical work at LJMU has supported extensive theoretical studies by CFD carried out by staff at Arup (consulting engineers) for the Market Transformation Programme. A future phase will study user satisfaction in their own homes where user satisfaction will be surveyed and linked to the physical performance of the shower.

Tau Kung | NREL

Science.gov Websites

Tau Kung Photo of Feitau Kung Tau Kung Commercial Buildings Research Engineer Feitau.Kung@nrel.gov evaluating building system energy performance in commercial settings, such as office, healthcare, higher

Prospect for measuring the CP phase in the $$h\\tau\\tau$$ coupling at the LHC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Askew, Andrew; Jaiswal, Prerit; Okui, Takemichi

The search for a new source of CP violation is one of the most important endeavors in particle physics. A particularly interesting way to perform this search is to probe the CP phase in themore » $$h\\tau\\tau$$ coupling, as the phase is currently completely unconstrained by all existing data. Recently, a novel variable $$\\Theta$$ was proposed for measuring the CP phase in the $$h\\tau\\tau$$ coupling through the $$\\tau^\\pm \\to \\pi^\\pm \\pi^0 \

Prospect for measuring the CP phase in the $$h\\tau\\tau$$ coupling at the LHC

DOE PAGES

Askew, Andrew; Jaiswal, Prerit; Okui, Takemichi; ...

2015-04-01

The search for a new source of CP violation is one of the most important endeavors in particle physics. A particularly interesting way to perform this search is to probe the CP phase in themore » $$h\\tau\\tau$$ coupling, as the phase is currently completely unconstrained by all existing data. Recently, a novel variable $$\\Theta$$ was proposed for measuring the CP phase in the $$h\\tau\\tau$$ coupling through the $$\\tau^\\pm \\to \\pi^\\pm \\pi^0 \

Physics of neutrino flavor transformation through matter-neutrino resonances

NASA Astrophysics Data System (ADS)

Wu, Meng-Ru; Duan, Huaiyu; Qian, Yong-Zhong

2016-01-01

In astrophysical environments such as core-collapse supernovae and neutron star-neutron star or neutron star-black hole mergers where dense neutrino media are present, matter-neutrino resonances (MNRs) can occur when the neutrino propagation potentials due to neutrino-electron and neutrino-neutrino forward scattering nearly cancel each other. We show that neutrino flavor transformation through MNRs can be explained by multiple adiabatic solutions similar to the Mikheyev-Smirnov-Wolfenstein mechanism. We find that for the normal neutrino mass hierarchy, neutrino flavor evolution through MNRs can be sensitive to the shape of neutrino spectra and the adiabaticity of the system, but such sensitivity is absent for the inverted hierarchy.

An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

PubMed Central

Cavallini, Annalisa; Brewerton, Suzanne; Bell, Amanda; Sargent, Samantha; Glover, Sarah; Hardy, Clare; Moore, Roger; Calley, John; Ramachandran, Devaki; Poidinger, Michael; Karran, Eric; Davies, Peter; Hutton, Michael; Szekeres, Philip; Bose, Suchira

2013-01-01

Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia. Identifying the kinases involved in the pathological phosphorylation of tau may identify novel targets for AD. We used an unbiased approach to study the effect of 352 human kinases on their ability to phosphorylate tau at epitopes associated with AD. The kinases were overexpressed together with the longest form of human tau in human neuroblastoma cells. Levels of total and phosphorylated tau (epitopes Ser(P)-202, Thr(P)-231, Ser(P)-235, and Ser(P)-396/404) were measured in cell lysates using AlphaScreen assays. GSK3α, GSK3β, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes. We further dissected the effects of GSK3α and GSK3β using pharmacological and genetic tools in hTau primary cortical neurons. Pathway analysis of the kinases identified in the screen suggested mechanisms for regulation of total tau levels and tau phosphorylation; for example, kinases that affect total tau levels do so by inhibition or activation of translation. A network fishing approach with the kinase hits identified other key molecules putatively involved in tau phosphorylation pathways, including the G-protein signaling through the Ras family of GTPases (MAPK family) pathway. The findings identify novel tau kinases and novel pathways that may be relevant for AD and other tauopathies. PMID:23798682

Structure-based inhibitors of tau aggregation

NASA Astrophysics Data System (ADS)

Seidler, P. M.; Boyer, D. R.; Rodriguez, J. A.; Sawaya, M. R.; Cascio, D.; Murray, K.; Gonen, T.; Eisenberg, D. S.

2018-02-01

Aggregated tau protein is associated with over 20 neurological disorders, which include Alzheimer's disease. Previous work has shown that tau's sequence segments VQIINK and VQIVYK drive its aggregation, but inhibitors based on the structure of the VQIVYK segment only partially inhibit full-length tau aggregation and are ineffective at inhibiting seeding by full-length fibrils. Here we show that the VQIINK segment is the more powerful driver of tau aggregation. Two structures of this segment determined by the cryo-electron microscopy method micro-electron diffraction explain its dominant influence on tau aggregation. Of practical significance, the structures lead to the design of inhibitors that not only inhibit tau aggregation but also inhibit the ability of exogenous full-length tau fibrils to seed intracellular tau in HEK293 biosensor cells into amyloid. We also raise the possibility that the two VQIINK structures represent amyloid polymorphs of tau that may account for a subset of prion-like strains of tau.

Sources of extracellular tau and its signaling.

PubMed

Avila, Jesús; Simón, Diana; Díaz-Hernández, Miguel; Pintor, Jesús; Hernández, Félix

2014-01-01

The pathology associated with tau protein, tauopathy, has been recently analyzed in different disorders, leading to the suggestion that intracellular and extracellular tau may itself be the principal agent in the transmission and spreading of tauopathies. Tau pathology is based on an increase in the amount of tau, an increase in phosphorylated tau, and/or an increase in aggregated tau. Indeed, phosphorylated tau protein is the main component of tau aggregates, such as the neurofibrillary tangles present in the brain of Alzheimer's disease patients. It has been suggested that intracellular tau could be toxic to neurons in its phosphorylated and/or aggregated form. However, extracellular tau could also damage neurons and since neuronal death is widespread in Alzheimer's disease, mainly among cholinergic neurons, these cells may represent a possible source of extracellular tau. However, other sources of extracellular tau have been proposed that are independent of cell death. In addition, several ways have been proposed for cells to interact with, transmit, and spread extracellular tau, and to transduce signals mediated by this tau. In this work, we will discuss the role of extracellular tau in the spreading of the tau pathology.

46 CFR 153.216 - Shower and eyewash fountains.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Shower and eyewash fountains. 153.216 Section 153.216... Vessel Requirements § 153.216 Shower and eyewash fountains. (a) Each non-self-propelled ship must have a fixed or portable shower and eyewash fountain that operates during cargo transfer and meets paragraph (c...

46 CFR 153.216 - Shower and eyewash fountains.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Shower and eyewash fountains. 153.216 Section 153.216... Vessel Requirements § 153.216 Shower and eyewash fountains. (a) Each non-self-propelled ship must have a fixed or portable shower and eyewash fountain that operates during cargo transfer and meets paragraph (c...

Effects of antibodies to phosphorylated and non-phosphorylated tau on in vitro tau phosphorylation at Serine-199: Preliminary report.

PubMed

Loeffler, David A; Smith, Lynnae M; Klaver, Andrea C; Martić, Sanela

2015-07-01

Phosphorylation of multiple amino acids on tau protein ("hyperphosphorylation") is required for the development of tau pathology in Alzheimer's disease. Administration of anti-tau antibodies to transgenic "tauopathy mice" has been shown to reduce their tau pathology but the mechanisms responsible are unclear. To examine the effects of anti-tau antibodies on tau phosphorylation, we used western blots to study the effects of three antibodies to phosphorylated tau (pTau), namely anti-pTau S199, T231, and S396, and three antibodies to non-phosphorylated tau on in vitro phosphorylation of recombinant human tau-441 at S199. Inclusion of an anti-pTau T231 antibody in the phosphorylation reaction reduced the intensity of monomeric pTau S199 in western blots of denaturing gels, but the other antibodies had no apparent effects on this process. Surprisingly, including all three anti-phospho-tau antibodies in the reaction did not reduce the intensity of the monomer band, possibly due to steric hindrance between the antibodies. These preliminary findings suggest that anti-tau antibodies may have minimal direct effects on tau phosphorylation. Limitations of using western blots to examine the effects of anti-tau antibodies on this process were found to include between-experiment variability in pTau band densities and poor resolution of high molecular weight pTau oligomers. The presence of bands representing immunoglobulins as well as pTau may also complicate interpretation of the western blots. Further studies are indicated to examine the effects of anti-pTau antibodies on phosphorylation of other tau amino acids in addition to S199. Copyright © 2015 Elsevier Inc. All rights reserved.

Plasma tau in Alzheimer disease.

PubMed

Mattsson, Niklas; Zetterberg, Henrik; Janelidze, Shorena; Insel, Philip S; Andreasson, Ulf; Stomrud, Erik; Palmqvist, Sebastian; Baker, David; Tan Hehir, Cristina A; Jeromin, Andreas; Hanlon, David; Song, Linan; Shaw, Leslie M; Trojanowski, John Q; Weiner, Michael W; Hansson, Oskar; Blennow, Kaj

2016-10-25

To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related to changes in cognition, CSF biomarkers of AD pathology (including β-amyloid [Aβ] and tau), brain atrophy, and brain metabolism. This was a study of plasma tau in prospectively followed patients with AD (n = 179), patients with mild cognitive impairment (n = 195), and cognitive healthy controls (n = 189) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and cross-sectionally studied patients with AD (n = 61), mild cognitive impairment (n = 212), and subjective cognitive decline (n = 174) and controls (n = 274) from the Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study at Lund University, Sweden. A total of 1284 participants were studied. Associations were tested between plasma tau and diagnosis, CSF biomarkers, MRI measures, 18 fluorodeoxyglucose-PET, and cognition. Higher plasma tau was associated with AD dementia, higher CSF tau, and lower CSF Aβ 42 , but the correlations were weak and differed between ADNI and BioFINDER. Longitudinal analysis in ADNI showed significant associations between plasma tau and worse cognition, more atrophy, and more hypometabolism during follow-up. Plasma tau partly reflects AD pathology, but the overlap between normal aging and AD is large, especially in patients without dementia. Despite group-level differences, these results do not support plasma tau as an AD biomarker in individual people. Future studies may test longitudinal plasma tau measurements in AD. © 2016 American Academy of Neurology.

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

PubMed Central

Iijima-Ando, Kanae; Sekiya, Michiko; Suzuki, Emiko; Lu, Bingwei; Iijima, Koichi M.

2012-01-01

Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions trigger tau abnormality in AD is not fully understood. A reduction in the number of mitochondria in the axon has been implicated in AD. In this study, we investigated whether and how loss of axonal mitochondria promotes tau phosphorylation and toxicity in vivo. Using transgenic Drosophila expressing human tau, we found that RNAi–mediated knockdown of milton or Miro, an adaptor protein essential for axonal transport of mitochondria, enhanced human tau-induced neurodegeneration. Tau phosphorylation at an AD–related site Ser262 increased with knockdown of milton or Miro; and partitioning defective-1 (PAR-1), the Drosophila homolog of mammalian microtubule affinity-regulating kinase, mediated this increase of tau phosphorylation. Tau phosphorylation at Ser262 has been reported to promote tau detachment from microtubules, and we found that the levels of microtubule-unbound free tau increased by milton knockdown. Blocking tau phosphorylation at Ser262 site by PAR-1 knockdown or by mutating the Ser262 site to unphosphorylatable alanine suppressed the enhancement of tau-induced neurodegeneration caused by milton knockdown. Furthermore, knockdown of milton or Miro increased the levels of active PAR-1. These results suggest that an increase in tau phosphorylation at Ser262 through PAR-1 contributes to tau-mediated neurodegeneration under a pathological condition in which axonal mitochondria is depleted. Intriguingly, we found that knockdown of milton or Miro alone caused late-onset neurodegeneration in the fly brain, and this neurodegeneration could be suppressed by knockdown of Drosophila tau or PAR-1. Our results suggest that loss of axonal mitochondria may play an important role in tau phosphorylation and toxicity in the pathogenesis of AD. PMID:22952452

Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies.

PubMed

Arima, Kunimasa

2006-10-01

The microtubule-associated protein tau aggregates into filaments in the form of neurofibrillary tangles, neuropil threads and argyrophilic grains in neurons, in the form of variable astrocytic tangles in astrocytes and in the form of coiled bodies and argyrophilic threads in oligodendrocytes. These tau filaments may be classified into two types, straight filaments or tubules with 9-18 nm diameters and "twisted ribbons" composed of two parallel aligned components. In the same disease, the fine structure of tau filaments in glial cells roughly resembles that in neurons. In sporadic tauopathies, individual tau filaments show characteristic sizes, shapes and arrangements, and therefore contribute to neuropathologic differential diagnosis. In frontotemporal dementias caused by tau gene mutations, variable filamentous profiles were observed in association with mutation sites and insoluble tau isoforms, including straight filaments or tubules, paired helical filament-like filaments, and twisted ribbons. Pre-embedding immunoelectron microscopic studies were carried out using anti-3-repeat tau and anti-4-repeat tau specific antibodies, RD3 and RD4. Straight tubules in neuronal and astrocytic Pick bodies were immunolabeled by the anti-3-repeat tau antibody. The anti-4-repeat tau antibody recognized abnormal tubules comprising neurofibrillary tangles, coiled bodies and argyrophilic threads in progressive supranuclear palsy (PSP) and corticobasal degeneration. In the pre-embedding immunoelectron microscopic study using the phosphorylated tau AT8 antibody, tuft-shaped astrocytes of PSP were found to be composed of bundles of abnormal tubules in processes and perikarya of protoplasmic astrocytes. In this study, the 3-repeat tau or 4-repeat tau epitope was detected in situ at the ultrastructural level in abnormal tubules in representative pathological lesions in Pick's disease, PSP and corticobasal degeneration.

Acquiring information about neutrino parameters by detecting supernova neutrinos

NASA Astrophysics Data System (ADS)

Huang, Ming-Yang; Guo, Xin-Heng; Young, Bing-Lin

2010-08-01

We consider the supernova shock effects, the Mikheyev-Smirnov-Wolfenstein effects, the collective effects, and the Earth matter effects in the detection of type II supernova neutrinos on the Earth. It is found that the event number of supernova neutrinos depends on the neutrino mass hierarchy, the neutrino mixing angle θ13, and neutrino masses. Therefore, we propose possible methods to identify the mass hierarchy and acquire information about θ13 and neutrino masses by detecting supernova neutrinos. We apply these methods to some current neutrino experiments.

1997 Leonid Shower From Space

NASA Technical Reports Server (NTRS)

Jenniskens, Peter; Nugent, David; Murthy, Jayant; Tedesco, Ed; DeVincenzi, Donal L. (Technical Monitor)

2000-01-01

In November 1997, the Midcourse Space Experiment satellite (MSX) was deployed to observe the Leonid shower from space. The shower lived up to expectations, with abundant bright fireballs. Twenty-nine meteors were detected by a wide-angle, visible wavelength, camera near the limb of the Earth in a 48-minute interval, and three meteors by the narrow field camera. This amounts to a meteoroid influx of 5.5 +/- 0.6 10(exp -5)/sq km hr for masses greater than 0.3 gram. The limiting magnitude for limb observations of Leonid meteors was measured at M(sub v) = -1.5 magn The Leonid shower magnitude population index was 1.6 +/- 0.2 down to M(sub v) = -7 magn., with no sign of an upper mass cut-off.

Radio Measurements of Air Showers with LOPES

NASA Astrophysics Data System (ADS)

Schröder, F. G.; Apel, W. D.; Arteaga-Velazquez, J. C.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Cantoni, E.; Chiavassa, A.; Daumiller, K.; de Souza, V.; Di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Fuchs, B.; Fuhrmann, D.; Gemmeke, H.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Krömer, O.; Kuijpers, J.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Melissas, M.; Morello, C.; Oehlschläger, J.; Palmieri, N.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Rühle, C.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Sima, O.; Toma, G.; Trinchero, G. C.; Weindl, A.; Wochele, J.; Zabierowski, J.; Zensus, J. A.

2013-02-01

LOPES is a digital antenna array for the radio measurement of cosmic-ray air showers at energies around 1017 eV. It is triggered by the KASCADE-Grande air-shower array at the Karlsruhe Institute of Technology (KIT), Germany. Because of an absolute amplitude calibration and a sophisticated data analysis, LOPES can test models for the radio emission to an up-to-now unachieved level, thus improving our understanding of the radio emission mechanisms. Recent REAS simulations of the air-shower radio emission come closer to the measurements than any previously tested simulations. We have determined the radio-reconstruction precision of interesting air-shower parameters by comparing LOPES reconstructions to both REAS simulations and KASCADE-Grande measurements, and present our latest results for the angular resolution, the energy and the Xmax reconstruction based on the radio measurement of about 500 air showers. Although the precision of LOPES is limited by the high level of anthropogenic noise at KIT, it opens a promising perspective for next-generation radio arrays in regions with a lower ambient noise level.

Neutrinos

Science.gov Websites

Neutrinos What are they? Neutrinos are members of the Standard Model, belonging to a class of the mass could be and the mass differences between flavors of neutrinos, although there are many current experiments designed to probe this question. The difficulty lies in the fact that neutrinos are

Increasing Geminid meteor shower activity

NASA Astrophysics Data System (ADS)

Ryabova, G. O.; Rendtel, J.

2018-03-01

Mathematical modelling has shown that activity of the Geminid meteor shower should rise with time, and that was confirmed by analysis of visual observations 1985-2016. We do not expect any outburst activity of the Geminid shower in 2017, even though the asteroid (3200) Phaethon has a close approach to Earth in December of 2017. A small probability to observe dust ejected at perihelia 2009-2016 still exists.

Escitalopram Ameliorates Forskolin-Induced Tau Hyperphosphorylation in HEK239/tau441 Cells.

PubMed

Ren, Qing-Guo; Wang, Yan-Juan; Gong, Wei-Gang; Zhou, Qi-Da; Xu, Lin; Zhang, Zhi-Jun

2015-06-01

To investigate the effect of escitalopram (a widely used and highly efficacious antidepressant from the SSRI class) on tau hyperphosphorylation, HEK293/tau441 cells were pretreated with 4 μM of forskolin for 2 h. Then we treated the cells with different doses of escitalopram (0, 5, 10, 20, 40, 80 μM) for 22 h. We measured the phosphorylation level of tau by Western blotting. It was shown that escitalopram could protect tau from hyperphosphorylation induced by pharmacological activation of protein kinase A (PKA) at a dose of 20, 40, and 80 μM in vitro. Interestingly, the same dose of escitalopram could also increase the level of serine-9-phosphorylated GSK-3β (inactive form) and the phosphorylation level of Akt at Ser473 (active form) with no significant change in the level of total GSK-3β and Akt. Unexpectedly, 5-hydroxytryptamine 1A receptor (5-HT1A) agonist 8-OH-DPAT did not decrease forskolin-induced tau hyperphosphorylation. Our results suggest that escitalopram can ameliorate forskolin-induced tau hyperphosphorylation, which is not through the typical 5-HT1A pathway, and Akt/GSK-3β signaling pathway is involved. These findings may support an effective role of antidepressants in the prevention of dementia associated with depression in patients.

Neutrino Detectors

NASA Astrophysics Data System (ADS)

von Feilitzsch, Franz; Lanfranchi, Jean-Côme; Wurm, Michael

The neutrino was postulated by Wolfgang Pauli in the early 1930s, but could only be detected for the first time in the 1950s. Ever since scientists all around the world have worked on the detection and understanding of this particle which so scarcely interacts with matter. Depending on the origin and nature of the neutrino, various types of experiments have been developed and operated. In this entry, we will review neutrino detectors in terms of neutrino energy and associated detection technique as well as the scientific outcome of some selected examples. After a brief historical introduction, the detection of low-energy neutrinos originating from nuclear reactors or from the Earth is used to illustrate the principles and difficulties which are encountered in detecting neutrinos. In the context of solar neutrino spectroscopy, where the neutrino is used as a probe for astrophysics, three different types of neutrino detectors are presented - water Čerenkov, radiochemical, and liquid-scintillator detectors. Moving to higher neutrino energies, we discuss neutrinos produced by astrophysical sources and from accelerators. The entry concludes with an overview of a selection of future neutrino experiments and their scientific goals.

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

PubMed Central

Luo, Wenjie; Liu, Wencheng; Hu, Xiaoyan; Hanna, Mary; Caravaca, April; Paul, Steven M.

2015-01-01

Microglia have been shown to contribute to the clearance of brain amyloid β peptides (Aβ), the major component of amyloid plaques, in Alzheimer’s disease (AD). However, it is not known whether microglia play a similar role in the clearance of tau, the major component of neurofibrillary tangles (NFTs). We now report that murine microglia rapidly internalize and degrade hyperphosphorylated pathological tau isolated from AD brain tissue in a time-dependent manner in vitro. We further demonstrate that microglia readily degrade human tau species released from AD brain sections and eliminate NFTs from brain sections of P301S tauopathy mice. The anti-tau monoclonal antibody MC1 enhances microglia-mediated tau degradation in an Fc-dependent manner. Our data identify a potential role for microglia in the degradation and clearance of pathological tau species in brain and provide a mechanism explaining the potential therapeutic actions of passively administered anti-tau monoclonal antibodies. PMID:26057852

CSF tau and tau/Aβ42 predict cognitive decline in Parkinson's disease.

PubMed

Liu, Changqin; Cholerton, Brenna; Shi, Min; Ginghina, Carmen; Cain, Kevin C; Auinger, Peggy; Zhang, Jing

2015-03-01

A substantial proportion of patients with Parkinson's disease (PD) have concomitant cognitive dysfunction. Identification of biomarker profiles that predict which PD patients have a greater likelihood for progression of cognitive symptoms is pressingly needed for future treatment and prevention approaches. Subjects were drawn from the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) study, a large clinical trial that enrolled initially untreated PD patients. For the current study, Phase One encompassed trial baseline until just prior to levodopa administration (n = 403), and Phase Two spanned the initiation of levodopa treatment until the end of cognitive follow-up (n = 305). Correlations and linear mixed models were performed to determine cross-sectional and longitudinal associations between baseline amyloid β1-42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) and measures of memory and executive function. Analyses also considered APOE genotype and tremor- vs. rigidity-dominant phenotype. No association was found between baseline CSF biomarkers and cognitive test performance during Phase One. However, once levodopa treatment was initiated, higher p-tau and p-tau/Aβ42 predicted subsequent decline on cognitive tasks involving both memory and executive functions. The interactions between biomarkers and cognition decline did not appear to be influenced by levodopa dosage, APOE genotype or motor phenotype. The current study has, for the first time, demonstrated the possible involvement of tau species, whose gene (MAPT) has been consistently linked to the risk of PD by genome-wide association studies, in the progression of cognitive symptoms in PD. Copyright © 2015 Elsevier Ltd. All rights reserved.

The 2017 Meteor Shower Activity Forecast for Earth Orbit

NASA Technical Reports Server (NTRS)

Moorhead, Althea; Cooke, Bill; Moser, Danielle

2017-01-01

Most meteor showers will display typical activity levels in 2017. Perseid activity is expected to be higher than normal but less than in 2016; rates may reach 80% of the peak ZHR in 2016. Despite this enhancement, the Perseids rank 4th in flux for 0.04-cm-equivalent meteoroids: the Geminids (GEM), Daytime Arietids (ARI), and Southern delta Aquariids (SDA) all produce higher fluxes. Aside from heightened Perseid activity, the 2017 forecast includes a number of changes. In 2016, the Meteoroid Environment Office used 14 years of shower flux data to revisit the activity profiles of meteor showers included in the annual forecast. Both the list of showers and the shape of certain major showers have been revised. The names and three-letter shower codes were updated to match those in the International Astronomical Union (IAU) Meteor Data Center, and a number of defunct or insignificant showers were removed. The most significant of these changes are the increased durations of the Daytime Arietid (ARI) and Geminid (GEM) meteor showers. This document is designed to supplement spacecraft risk assessments that incorporate an annual averaged meteor shower flux (as is the case with all NASA meteor models). Results are presented relative to this baseline and are weighted to a constant kinetic energy. Two showers - the Daytime Arietids (ARI) and the Geminids (GEM) - attain flux levels approaching that of the baseline meteoroid environment for 0.1-cm-equivalent meteoroids. This size is the threshold for structural damage. These two showers, along with the Quadrantids (QUA) and Perseids (PER), exceed the baseline flux for 0.3-cm-equivalent particles, which is near the limit for pressure vessel penetration. Please note, however, that meteor shower fluxes drop dramatically with increasing particle size. As an example, the Arietids contribute a flux of about 5x10(exp -6) meteoroids m(exp -2) hr-1 in the 0.04-cm-equivalent range, but only 1x10(exp -8) meteoroids m(sub -2) hr-1 for the 0

Depth Distribution Of The Maxima Of Extensive Air Shower

NASA Technical Reports Server (NTRS)

Adams, J. H.; Howell, L. W.

2003-01-01

Observations of the extensive air showers from space can be free from interference by low altitude clouds and aerosols if the showers develop at a sufficiently high altitude. In this paper we explore the altitude distribution of shower maxima to determine the fraction of all showers that will reach their maxima at sufficient altitudes to avoid interference from these lower atmosphere phenomena. Typically the aerosols are confined within a planetary boundary layer that extends from only 2-3 km above the Earth's surface. Cloud top altitudes extend above 15 km but most are below 4 km. The results reported here show that more than 75% of the showers that will be observed by EUSO have maxima above the planetary boundary layer. The results also show that more than 50% of the showers that occur on cloudy days have their maxima above the cloud tops.

Extensive Air Showers in the Classroom

ERIC Educational Resources Information Center

Badala, A.; Blanco, F.; La Rocca, P.; Pappalardo, G. S.; Pulvirenti, A.; Riggi, F.

2007-01-01

The basic properties of extensive air showers of particles produced in the interaction of a high-energy primary cosmic ray in the Earth's atmosphere are discussed in the context of educational cosmic ray projects involving undergraduate students and high-school teams. Simulation results produced by an air shower development code were made…

Weak gauge boson radiation in parton showers

NASA Astrophysics Data System (ADS)

Christiansen, Jesper R.; Sjöstrand, Torbjörn

2014-04-01

The emission of W and Z gauge bosons off quarks is included in a traditional QCD + QED shower. The unitarity of the shower algorithm links the real radiation of the weak gauge bosons to the negative weak virtual corrections. The shower evolution process leads to a competition between QCD, QED and weak radiation, and allows for W and Z boson production inside jets. Various effects on LHC physics are studied, both at low and high transverse momenta, and effects at higher-energy hadron colliders are outlined.

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.

PubMed

Congdon, Erin E; Lin, Yan; Rajamohamedsait, Hameetha B; Shamir, Dov B; Krishnaswamy, Senthilkumar; Rajamohamedsait, Wajitha J; Rasool, Suhail; Gonzalez, Veronica; Levenga, Josien; Gu, Jiaping; Hoeffer, Charles; Sigurdsson, Einar M

2016-08-30

A few tau immunotherapies are now in clinical trials with several more likely to be initiated in the near future. A priori, it can be anticipated that an antibody which broadly recognizes various pathological tau aggregates with high affinity would have the ideal therapeutic properties. Tau antibodies 4E6 and 6B2, raised against the same epitope region but of varying specificity and affinity, were tested for acutely improving cognition and reducing tau pathology in transgenic tauopathy mice and neuronal cultures. Surprisingly, we here show that one antibody, 4E6, which has low affinity for most forms of tau acutely improved cognition and reduced soluble phospho-tau, whereas another antibody, 6B2, which has high affinity for various tau species was ineffective. Concurrently, we confirmed and clarified these efficacy differences in an ex vivo model of tauopathy. Alzheimer's paired helical filaments (PHF) were toxic to the neurons and increased tau levels in remaining neurons. Both toxicity and tau seeding were prevented by 4E6 but not by 6B2. Furthermore, 4E6 reduced PHF spreading between neurons. Interestingly, 4E6's efficacy relates to its high affinity binding to solubilized PHF, whereas the ineffective 6B2 binds mainly to aggregated PHF. Blocking 4E6's uptake into neurons prevented its protective effects if the antibody was administered after PHF had been internalized. When 4E6 and PHF were administered at the same time, the antibody was protective extracellularly. Overall, these findings indicate that high antibody affinity for solubilized PHF predicts efficacy, and that acute antibody-mediated improvement in cognition relates to clearance of soluble phospho-tau. Importantly, both intra- and extracellular clearance pathways are in play. Together, these results have major implications for understanding the pathogenesis of tauopathies and for development of immunotherapies.

Electroweak splitting functions and high energy showering

NASA Astrophysics Data System (ADS)

Chen, Junmou; Han, Tao; Tweedie, Brock

2017-11-01

We derive the electroweak (EW) collinear splitting functions for the Standard Model, including the massive fermions, gauge bosons and the Higgs boson. We first present the splitting functions in the limit of unbroken SU(2) L × U(1) Y and discuss their general features in the collinear and soft-collinear regimes. These are the leading contributions at a splitting scale ( k T ) far above the EW scale ( v). We then systematically incorporate EW symmetry breaking (EWSB), which leads to the emergence of additional "ultra-collinear" splitting phenomena and naive violations of the Goldstone-boson Equivalence Theorem. We suggest a particularly convenient choice of non-covariant gauge (dubbed "Goldstone Equivalence Gauge") that disentangles the effects of Goldstone bosons and gauge fields in the presence of EWSB, and allows trivial book-keeping of leading power corrections in v/ k T . We implement a comprehensive, practical EW showering scheme based on these splitting functions using a Sudakov evolution formalism. Novel features in the implementation include a complete accounting of ultra-collinear effects, matching between shower and decay, kinematic back-reaction corrections in multi-stage showers, and mixed-state evolution of neutral bosons ( γ/ Z/ h) using density-matrices. We employ the EW showering formalism to study a number of important physical processes at O (1-10 TeV) energies. They include (a) electroweak partons in the initial state as the basis for vector-boson-fusion; (b) the emergence of "weak jets" such as those initiated by transverse gauge bosons, with individual splitting probabilities as large as O (35%); (c) EW showers initiated by top quarks, including Higgs bosons in the final state; (d) the occurrence of O (1) interference effects within EW showers involving the neutral bosons; and (e) EW corrections to new physics processes, as illustrated by production of a heavy vector boson ( W ') and the subsequent showering of its decay products.

Physics of neutrino flavor transformation through matter–neutrino resonances

DOE PAGES

Wu, Meng -Ru; Duan, Huaiyu; Qian, Yong -Zhong

2015-11-17

In astrophysical environments such as core-collapse supernovae and neutron star–neutron star or neutron star–black hole mergers where dense neutrino media are present, matter–neutrino resonances (MNRs) can occur when the neutrino propagation potentials due to neutrino–electron and neutrino–neutrino for-ward scattering nearly cancel each other. We show that neutrino flavor transformation through MNRs can be explained by multiple adiabatic solutions similar to the Mikheyev–Smirnov–Wolfenstein mecha-nism. As a result, we find that for the normal neutrino mass hierarchy, neutrino flavor evolution through MNRs can be sensitive to the shape of neutrino spectra and the adiabaticity of the system, but such sensitivity is absentmore » for the inverted hierarchy.« less

Satellite Investigation of Atmospheric Metal Deposition During Meteor Showers

NASA Astrophysics Data System (ADS)

Correira, J.; Aikin, A. C.; Grebowsky, J. M.

2008-12-01

Using the nadir-viewing Global Ozone Measuring Experiment (GOME) UV/VIS spectrometer on the ERS-2 satellite, we investigate short term variations in the magnesium column densities and any connection to possible enhanced mass deposition during a meteor shower. We derive a time dependent mass flux rate due to meteor showers using published estimates of mass density and activity profiles of meteor showers. An average daily mass flux rate is also calculated and used as a baseline against which calculated shower mass flux rates are compared. These theoretical mass flux rates are then compared with GOME derived metal column densities from the years 1996 - 2001.There appears to be little correlation between theoretical mass flux rates and changes in the Mg and Mg+ metal column densities. A possible explanation for the lack of a shower related increase in metal concentrations may be differences in the mass regimes dominating the average background mass flux and shower mass flux.

Metal concentrations in the upper atmosphere during meteor showers

NASA Astrophysics Data System (ADS)

Correira, J.; Aikin, A. C.; Grebowsky, J. M.; Burrows, J. P.

2010-02-01

Using the nadir-viewing Global Ozone Measuring Experiment (GOME) UV/VIS spectrometer on the ERS-2 satellite, we investigate short term variations in the vertical magnesium column densities in the atmosphere and any connection to possible enhanced mass deposition during a meteor shower. Time-dependent mass influx rates are derived for all the major meteor showers using published estimates of mass density and temporal profiles of meteor showers. An average daily sporadic background mass flux rate is also calculated and used as a baseline against which calculated shower mass flux rates are compared. These theoretical mass flux rates are then compared with GOME derived metal vertical column densities of Mg and Mg+ from the years 1996-2001. There is no correlation between theoretical mass flux rates and changes in the Mg and Mg+ metal column densities. A possible explanation for the lack of a shower related increase in metal concentrations may be differences in the mass regimes dominating the average background mass flux and shower mass flux.

Metal concentrations in the upper atmosphere during meteor showers

NASA Astrophysics Data System (ADS)

Correira, J.; Aikin, A. C.; Grebowsky, J. M.; Burrows, J. P.

2009-09-01

Using the nadir-viewing Global Ozone Measuring Experiment (GOME) UV/VIS spectrometer on the ERS-2 satellite, we investigate short term variations in the vertical magnesium column densities in the atmosphere and any connection to possible enhanced mass deposition during a meteor shower. Time-dependent mass influx rates are derived for all the major meteor showers using published estimates of mass density and temporal profiles of meteor showers. An average daily sporadic background mass flux rate is also calculated and used as a baseline against which calculated shower mass flux rates are compared. These theoretical mass flux rates are then compared with GOME derived metal vertical column densities of Mg and Mg+ from the years 1996-2001. There is no correlation between theoretical mass flux rates and changes in the Mg and Mg+ metal column densities. A possible explanation for the lack of a shower related increase in metal concentrations may be differences in the mass regimes dominating the average background mass flux and shower mass flux.

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography.

PubMed

Mielke, Michelle M; Hagen, Clinton E; Xu, Jing; Chai, Xiyun; Vemuri, Prashanthi; Lowe, Val J; Airey, David C; Knopman, David S; Roberts, Rosebud O; Machulda, Mary M; Jack, Clifford R; Petersen, Ronald C; Dage, Jeffrey L

2018-04-04

We examined and compared plasma phospho-tau181 (pTau181) and total tau: (1) across the Alzheimer's disease (AD) clinical spectrum; (2) in relation to brain amyloid β (Aβ) positron emission tomography (PET), tau PET, and cortical thickness; and (3) as a screening tool for elevated brain Aβ. Participants included 172 cognitively unimpaired, 57 mild cognitively impaired, and 40 AD dementia patients with concurrent Aβ PET (Pittsburgh compound B), tau PET (AV1451), magnetic resonance imaging, plasma total tau, and pTau181. Plasma total tau and pTau181 levels were higher in AD dementia patients than those in cognitively unimpaired. Plasma pTau181 was more strongly associated with both Aβ and tau PET. Plasma pTau181 was a more sensitive and specific predictor of elevated brain Aβ than total tau and was as good as, or better than, the combination of age and apolipoprotein E (APOE). Plasma pTau181 may have utility as a biomarker of AD pathophysiology and as a noninvasive screener for elevated brain Aβ. Copyright © 2018. Published by Elsevier Inc.

MST radar observations of Perseid meteor shower 2004

NASA Astrophysics Data System (ADS)

Venkata Phani Kumar, D.; Reddy, K. Chenna; Yellaiah, G.

2006-09-01

There was a special attention for Perseid meteor shower observations in view of the predictions of an intense activity on 11th August 2004 caused by a filament of dust drifting across the Earth's orbit. Results of a systematic study of Perseid meteor shower observations, carried out during 12-15 August 2004 using Indian MST radar are presented. Based on over 27 hours of observing time, we detected 2260 meteor echoes occurring between 80 km and 120 km with a mean height of 103 km. For our observations, the peak activity of the shower occured on 12/13 August, corresponding to solar longitude lambdao = 140.565± 0.16 with an average rate of 250 meteor echoes per hour. The SNR distribution of the echoes observed during the shower indicates that the smaller size meteoroids are more compared to larger size meteoroids in the perseid meteor stream. The three distinct peaks observed in the shower activity is presented and discussed.

ScienceCast 73: 2012 Perseid Meteor Shower

NASA Image and Video Library

2012-08-09

The Perseid meteor shower is underway. There's more to see than meteors, however, when the shower peaks on August 11th through 13th. The brightest planets in the solar system are lining up in the middle of the display.

SHiP: a new facility with a dedicated detector to search for new neutral particles and studying tau neutrino properties

NASA Astrophysics Data System (ADS)

Shevchenko, V.

2017-12-01

SHiP (Search for Hidden Particles) is a new general purpose fixed target facility, whose Technical Proposal has been recently reviewed by the CERN SPS Committee and by the CERN Research Board. The two boards recommended that the experiment proceeds further to a Comprehensive Design phase in the context of the new CERNWorking group "Physics Beyond Colliders", aiming at presenting a CERN strategy for the European Strategy meeting of 2019. In the initial phase of SHiP, the 400 GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2×1020 pot in 5 years. A dedicated detector, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below O(10) GeV/c2. The main focus will be the physics of the so-called Hidden Portals, i.e. search for Dark Photons, Light scalars and pseudo-scalars, and Heavy Neutrinos. The sensitivity to Heavy Neutrinos will allow for the first time to probe, in the mass range between the kaon and the charm meson mass, a coupling range for which Baryogenesis and active neutrino masses could also be explained. Another dedicated detector will allow the study of neutrino cross-sections and angular distributions.

Probing Neutrino Properties with Long-Baseline Neutrino Beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marino, Alysia

2015-06-29

This final report on an Early Career Award grant began in April 15, 2010 and concluded on April 14, 2015. Alysia Marino's research is focussed on making precise measurements of neutrino properties using intense accelerator-generated neutrino beams. As a part of this grant, she is collaborating on the Tokai-to-Kamioka (T2K) long-baseline neutrino experiment, currently taking data in Japan, and on the Deep Underground Neutrino Experiment (DUNE) design effort for a future Long-Baseline Neutrino Facility (LBNF) in the US. She is also a member of the NA61/SHINE particle production experiment at CERN, but as that effort is supported by other funds,more » it will not be discussed further here. T2K was designed to search for the disappearance of muon neutrinos (ν μ) and the appearance of electron neutrinos (ν e), using a beam of muon neutrino beam that travels 295 km across Japan towards the Super-Kamiokande detector. In 2011 T2K first reported indications of ν e appearance, a previously unobserved mode of neutrino oscillations. In the past year, T2K has published a combined analysis of ν μ disappearance and ν e appearance, and began collecting taking data with a beam of anti-neutrinos, instead of neutrinos, to search for hints of violation of the CP symmetry of the universe. The proposed DUNE experiment has similar physics goals to T2K, but will be much more sensitive due to its more massive detectors and new higher-intensity neutrino beam. This effort will be very high-priority particle physics project in the US over the next decade.« less

IAU Meteor Data Center-the shower database: A status report

NASA Astrophysics Data System (ADS)

Jopek, Tadeusz Jan; Kaňuchová, Zuzana

2017-09-01

Currently, the meteor shower part of Meteor Data Center database includes: 112 established showers, 563 in the working list, among them 36 have the pro tempore status. The list of shower complexes contains 25 groups, 3 have established status and 1 has the pro tempore status. In the past three years, new meteor showers submitted to the MDC database were detected amongst the meteors observed by CAMS stations (Cameras for Allsky Meteor Surveillance), those included in the EDMOND (European viDeo MeteOr Network Database), those collected by the Japanese SonotaCo Network, recorded in the IMO (International Meteor Organization) database, observed by the Croatian Meteor Network and on the Southern Hemisphere by the SAAMER radar. At the XXIX General Assembly of the IAU in Honolulu, Hawaii in 2015, the names of 18 showers were officially accepted and moved to the list of established ones. Also, one shower already officially named (3/SIA the Southern iota Aquariids) was moved back to the working list of meteor showers. At the XXIX GA IAU the basic shower nomenclature rule was modified, the new formulation predicates ;The general rule is that a meteor shower (and a meteoroid stream) should be named after the constellation that contains the nearest star to the radiant point, using the possessive Latin form;. Over the last three years the MDC database was supplemented with the earlier published original data on meteor showers, which permitted verification of the correctness of the MDC data and extension of bibliographic information. Slowly but surely new database software options are implemented, and software bugs are corrected.

Changes in tau phosphorylation in hibernating rodents.

PubMed

León-Espinosa, Gonzalo; García, Esther; García-Escudero, Vega; Hernández, Félix; Defelipe, Javier; Avila, Jesús

2013-07-01

Tau is a cytoskeletal protein present mainly in the neurons of vertebrates. By comparing the sequence of tau molecule among different vertebrates, it was found that the variability of the N-terminal sequence in tau protein is higher than that of the C-terminal region. The N-terminal region is involved mainly in the binding of tau to cellular membranes, whereas the C-terminal region of the tau molecule contains the microtubule-binding sites. We have compared the sequence of Syrian hamster tau with the sequences of other hibernating and nonhibernating rodents and investigated how differences in the N-terminal region of tau could affect the phosphorylation level and tau binding to cell membranes. We also describe a change, in tau phosphorylation, on a casein kinase 1 (ck1)-dependent site that is found only in hibernating rodents. This ck1 site seems to play an important role in the regulation of tau binding to membranes. Copyright © 2013 Wiley Periodicals, Inc.

From Atmospheric Neutrinos to the Neutrino Mass Hierarchy

NASA Astrophysics Data System (ADS)

Kappes, A.

2015-08-01

After a brief introduction to neutrino oscillation, the article discusses how proposed detectors like PINGU and ORCA can use atmospheric neutrinos in the GeV range to determine the neutrino mass hierarchy, one of the crucial unknowns in the neutrino sector of particle physics, and what uncertainties on external input parameters have to be taken into account.

Monte Carlo Shower Counter Studies

NASA Technical Reports Server (NTRS)

Snyder, H. David

1991-01-01

Activities and accomplishments related to the Monte Carlo shower counter studies are summarized. A tape of the VMS version of the GEANT software was obtained and installed on the central computer at Gallaudet University. Due to difficulties encountered in updating this VMS version, a decision was made to switch to the UNIX version of the package. This version was installed and used to generate the set of data files currently accessed by various analysis programs. The GEANT software was used to write files of data for positron and proton showers. Showers were simulated for a detector consisting of 50 alternating layers of lead and scintillator. Each file consisted of 1000 events at each of the following energies: 0.1, 0.5, 2.0, 10, 44, and 200 GeV. Data analysis activities related to clustering, chi square, and likelihood analyses are summarized. Source code for the GEANT user subprograms and data analysis programs are provided along with example data plots.

Test results of a shower water recovery system

NASA Technical Reports Server (NTRS)

Verostko, Charles E.; Price, Donald F.; Garcia, Rafael; Pierson, Duane L.; Sauer, Richard L.

1987-01-01

A shower test was conducted recently at NASA-JSC in which waste water was reclaimed and reused. Test subjects showered in a prototype whole body shower following a protocol similar to that anticipated for Space Station. The waste water was purified using reverse osmosis followed by filtration through activated carbon and ion exchange resin beds. The reclaimed waste water was maintained free of microorganisms by using both heat and iodine. This paper discusses the test results, including the limited effectiveness of using iodine as a disinfectant and the evaluation of a Space Station candidate soap for showering. In addition, results are presented on chemical and microbial impurity content of water samples obtained from various locations in the water recovery process.

Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice*

PubMed Central

Ma, Qiu-Lan; Zuo, Xiaohong; Yang, Fusheng; Ubeda, Oliver J.; Gant, Dana J.; Alaverdyan, Mher; Teng, Edmond; Hu, Shuxin; Chen, Ping-Ping; Maiti, Panchanan; Teter, Bruce; Cole, Greg M.; Frautschy, Sally A.

2013-01-01

The mechanisms underlying Tau-related synaptic and cognitive deficits and the interrelationships between Tau species, their clearance pathways, and synaptic impairments remain poorly understood. To gain insight into these mechanisms, we examined these interrelationships in aged non-mutant genomic human Tau mice, with established Tau pathology and neuron loss. We also examined how these interrelationships changed with an intervention by feeding mice either a control diet or one containing the brain permeable beta-amyloid and Tau aggregate binding molecule curcumin. Transgene-dependent elevations in soluble and insoluble phospho-Tau monomer and soluble Tau dimers accompanied deficits in behavior, hippocampal excitatory synaptic markers, and molecular chaperones (heat shock proteins (HSPs)) involved in Tau degradation and microtubule stability. In human Tau mice but not control mice, HSP70, HSP70/HSP72, and HSP90 were reduced in membrane-enriched fractions but not in cytosolic fractions. The synaptic proteins PSD95 and NR2B were reduced in dendritic fields and redistributed into perikarya, corresponding to changes observed by immunoblot. Curcumin selectively suppressed levels of soluble Tau dimers, but not of insoluble and monomeric phospho-Tau, while correcting behavioral, synaptic, and HSP deficits. Treatment increased PSD95 co-immunoprecipitating with NR2B and, independent of transgene, increased HSPs implicated in Tau clearance. It elevated HSP90 and HSC70 without increasing HSP mRNAs; that is, without induction of the heat shock response. Instead curcumin differentially impacted HSP90 client kinases, reducing Fyn without reducing Akt. In summary, curcumin reduced soluble Tau and elevated HSPs involved in Tau clearance, showing that even after tangles have formed, Tau-dependent behavioral and synaptic deficits can be corrected. PMID:23264626

Measurement of radio emission from extensive air showers with LOPES

NASA Astrophysics Data System (ADS)

Hörandel, J. R.; Apel, W. D.; Arteaga, J. C.; Asch, T.; Badea, F.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Brüggemann, M.; Buchholz, P.; Buitink, S.; Cantoni, E.; Chiavassa, A.; Cossavella, F.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Ender, M.; Engel, R.; Falcke, H.; Finger, M.; Fuhrmann, D.; Gemmeke, H.; Ghia, P. L.; Glasstetter, R.; Grupen, C.; Haungs, A.; Heck, D.; Horneffer, A.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Kickelbick, D.; Krömer, O.; Kuijpers, J.; Lafebre, S.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Mayer, H. J.; Melissas, M.; Mitrica, B.; Morello, C.; Navarra, G.; Nehls, S.; Nigl, A.; Oehlschläger, J.; Over, S.; Palmieri, N.; Petcu, M.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Schröder, F.; Sima, O.; Singh, K.; Toma, G.; Trinchero, G. C.; Ulrich, H.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.

2011-02-01

A new method is explored to detect extensive air showers: the measurement of radio waves emitted during the propagation of the electromagnetic shower component in the magnetic field of the Earth. Recent results of the pioneering experiment LOPES are discussed. It registers radio signals in the frequency range between 40 and 80 MHz. The intensity of the measured radio emission is investigated as a function of different shower parameters, such as shower energy, angle of incidence, and distance to shower axis. In addition, new antenna types are developed in the framework of LOPESstar and new methods are explored to realize a radio self-trigger algorithm in real time.

The evolution of the Quarantid meteoroid shower

NASA Astrophysics Data System (ADS)

Babadzhanov, P. B.; Obrubov, Iu. V.; Pushkarev, A. N.

1991-02-01

The Everhart method is used to trace the orbital evolution of 36 model Quadrantid meteoroids over a 5750 yr period. It is found that the Quadrantid shower is responsible for eight related showers. These include the Ursids, the Northern and Southern delta-Aquarids, and the Carinids.

Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample.

PubMed

La Joie, Renaud; Bejanin, Alexandre; Fagan, Anne M; Ayakta, Nagehan; Baker, Suzanne L; Bourakova, Viktoriya; Boxer, Adam L; Cha, Jungho; Karydas, Anna; Jerome, Gina; Maass, Anne; Mensing, Ashley; Miller, Zachary A; O'Neil, James P; Pham, Julie; Rosen, Howard J; Tsai, Richard; Visani, Adrienne V; Miller, Bruce L; Jagust, William J; Rabinovici, Gil D

2018-01-23

To assess the relationships between fluid and imaging biomarkers of tau pathology and compare their diagnostic utility in a clinically heterogeneous sample. Fifty-three patients (28 with clinical Alzheimer disease [AD] and 25 with non-AD clinical neurodegenerative diagnoses) underwent β-amyloid (Aβ) and tau ([ 18 F]AV1451) PET and lumbar puncture. CSF biomarkers (Aβ 42 , total tau [t-tau], and phosphorylated tau [p-tau]) were measured by multianalyte immunoassay (AlzBio3). Receiver operator characteristic analyses were performed to compare discrimination of Aβ-positive AD from non-AD conditions across biomarkers. Correlations between CSF biomarkers and PET standardized uptake value ratios (SUVR) were assessed using skipped Pearson correlation coefficients. Voxelwise analyses were run to assess regional CSF-PET associations. [ 18 F]AV1451-PET cortical SUVR and p-tau showed excellent discrimination between Aβ-positive AD and non-AD conditions (area under the curve 0.92-0.94; ≤0.83 for other CSF measures), and reached 83% classification agreement. In the full sample, cortical [ 18 F]AV1451 was associated with all CSF biomarkers, most strongly with p-tau ( r = 0.75 vs 0.57 for t-tau and -0.49 for Aβ 42 ). When restricted to Aβ-positive patients with AD, [ 18 F]AV1451 SUVR correlated modestly with p-tau and t-tau (both r = 0.46) but not Aβ 42 ( r = 0.02). On voxelwise analysis, [ 18 F]AV1451 correlated with CSF p-tau in temporoparietal cortices and with t-tau in medial prefrontal regions. Within AD, Mini-Mental State Examination scores were associated with [ 18 F]AV1451-PET, but not CSF biomarkers. [ 18 F]AV1451-PET and CSF p-tau had comparable value for differential diagnosis. Correlations were robust in a heterogeneous clinical group but attenuated (although significant) in AD, suggesting that fluid and imaging biomarkers capture different aspects of tau pathology. This study provides Class III evidence that, in a clinical sample of patients with a variety

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers

PubMed Central

Puschmann, Andreas; Schöll, Michael; Ohlsson, Tomas; van Swieten, John; Honer, Michael; Englund, Elisabet

2016-01-01

Abstract Tau positron emission tomography ligands provide the novel possibility to image tau pathology in vivo. However, little is known about how in vivo brain uptake of tau positron emission tomography ligands relates to tau aggregates observed post-mortem. We performed tau positron emission tomography imaging with 18F-AV-1451 in three patients harbouring a p.R406W mutation in the MAPT gene, encoding tau. This mutation results in 3- and 4-repeat tau aggregates similar to those in Alzheimer’s disease, and many of the mutation carriers initially suffer from memory impairment and temporal lobe atrophy. Two patients with short disease duration and isolated memory impairment exhibited 18F-AV-1451 uptake mainly in the hippocampus and adjacent temporal lobe regions, correlating with glucose hypometabolism in corresponding regions. One patient died after 26 years of disease duration with dementia and behavioural deficits. Pre-mortem, there was 18F-AV-1451 uptake in the temporal and frontal lobes, as well as in the basal ganglia, which strongly correlated with the regional extent and amount of tau pathology in post-mortem brain sections. Amyloid-β (18F-flutemetamol) positron emission tomography scans were negative in all cases, as were stainings of brain sections for amyloid. This provides strong evidence that 18F-AV-1451 positron emission tomography can be used to accurately quantify in vivo the regional distribution of hyperphosphorylated tau protein. PMID:27357347

On noise treatment in radio measurements of cosmic ray air showers

NASA Astrophysics Data System (ADS)

Schröder, F. G.; Apel, W. D.; Arteaga, J. C.; Asch, T.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Buchholz, P.; Buitink, S.; Cantoni, E.; Chiavassa, A.; Daumiller, K.; de Souza, V.; Doll, P.; Engel, R.; Falcke, H.; Finger, M.; Fuhrmann, D.; Gemmeke, H.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Krömer, O.; Kuijpers, J.; Lafebre, S.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Melissas, M.; Morello, C.; Nehls, S.; Oehlschläger, J.; Palmieri, N.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Rühle, C.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Sima, O.; Toma, G.; Trinchero, G. C.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.

2012-01-01

Precise measurements of the radio emission by cosmic ray air showers require an adequate treatment of noise. Unlike to usual experiments in particle physics, where noise always adds to the signal, radio noise can in principle decrease or increase the signal if it interferes by chance destructively or constructively. Consequently, noise cannot simply be subtracted from the signal, and its influence on amplitude and time measurement of radio pulses must be studied with care. First, noise has to be determined consistently with the definition of the radio signal which typically is the maximum field strength of the radio pulse. Second, the average impact of noise on radio pulse measurements at individual antennas is studied for LOPES. It is shown that a correct treatment of noise is especially important at low signal-to-noise ratios: noise can be the dominant source of uncertainty for pulse height and time measurements, and it can systematically flatten the slope of lateral distributions. The presented method can also be transferred to other experiments in radio and acoustic detection of cosmic rays and neutrinos.

Expected rates with mini-arrays for air showers

NASA Technical Reports Server (NTRS)

Hazen, W. E.

1985-01-01

As a guide in the design of mini-arrays used to exploit the Linsley effect in the study of air showers, it is useful to calculate the expected rates. The results can aid in the choice of detectors and their placement or in predicting the utility of existing detector systems. Furthermore, the potential of the method can be appraised for the study of large showers. Specifically, we treat the case of a mini-array of dimensions small enough compared to the distance of axes of showers of interest so that it can be considered a point detector. The input information is taken from the many previous studies of air showers by other groups. The calculations will give: (1) the expected integral rate, F(sigma, rho), for disk thickness, sigma, or rise time, t sub 1/2, with local particle density, rho, as a parameter; (2) the effective detection area A(N) with sigma (min) and rho (min) and rho (min) as parameters; (3) the expected rate of collection of data F sub L (N) versus shower size, N.

SiPM application for a detector for UHE neutrinos tested at Sphinx station

NASA Astrophysics Data System (ADS)

Iori, M.; Atakisi, I. O.; Chiodi, G.; Denizli, H.; Ferrarotto, F.; Kaya, M.; Yilmaz, A.; Recchia, L.; Russ, J.

2014-04-01

We present the preliminary test results of the prototype detector, working at Sphinx Observatory Center, Jungfraujoch (~3800 m a.s.l.) HFSJG - Switzerland. This prototype detector is designed to measure large zenith angle showers produced by high energy neutrino interactions in the Earth crust. This station provides us an opportunity to understand if the prototype detector works safely (or not) under hard environmental conditions (the air temperature changes between -25 °C and -5 °C). The detector prototype is using silicon photomultiplier (SiPM) produced by SensL and DRS4 chip as read-out part. Measurements at different temperature at fixed bias voltage (~29.5 V) were performed to reconstruct tracks by Time Of Flight.

Treatment-as-usual (TAU) is anything but usual: a meta-analysis of CBT versus TAU for anxiety and depression.

PubMed

Watts, Sarah E; Turnell, Adrienne; Kladnitski, Natalie; Newby, Jill M; Andrews, Gavin

2015-04-01

There were three aims of this study, the first was to examine the efficacy of CBT versus treatment-as-usual (TAU) in the treatment of anxiety and depressive disorders, the second was to examine how TAU is defined in TAU control groups for those disorders, and the third was to explore whether the type of TAU condition influences the estimate of effects of CBT. A systematic search of Cochrane Central Register of Controlled Trials, PsycINFO, and CINAHL was conducted. 48 studies of CBT for depressive or anxiety disorders (n=6926) that specified that their control group received TAU were identified. Most (n=45/48) provided an explanation of the TAU group however there was significant heterogeneity amongst TAU conditions. The meta-analysis showed medium effects favoring CBT over TAU for both anxiety (g=0.69, 95% CI 0.47-0.92, p<0.001, n=1318) and depression (g=0.70, 95% CI 0.49-0.90, p<0.001, n=5054), with differential effects observed across TAU conditions. CBT is superior to TAU and the size of the effect of CBT compared to TAU depends on the nature of the TAU condition. The term TAU is used in different ways and should be more precisely described. The four key details to be reported can be thought of as "who, what, how many, and any additional treatments?" Copyright © 2014 Elsevier B.V. All rights reserved.

Observation of Upsilon(3S)-->tau+tau- and tests of lepton universality in Upsilon decays.

PubMed

Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Severini, H; Dytman, S A; Love, W; Savinov, V; Aquines, O; Li, Z; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Blusk, S; Butt, J; Horwitz, N; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Brock, I; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Wiss, J; Shepherd, M R

2007-02-02

Using data collected with the CLEO III detector at the CESR e+e- collider, we report on a first observation of the decay Upsilon(3S)-->tau+tau-, and precisely measure the ratio of branching fractions of Upsilon(nS), n=1, 2, 3, to tau+tau- and mu+mu- final states, finding agreement with expectations from lepton universality. We derive absolute branching fractions for these decays, and also set a limit on the influence of a low mass CP-odd Higgs boson in the decay of the Upsilon(1S).

Do cosmic ray air showers initiate lightning?: A statistical analysis of cosmic ray air showers and lightning mapping array data

NASA Astrophysics Data System (ADS)

Hare, B. M.; Dwyer, J. R.; Winner, L. H.; Uman, M. A.; Jordan, D. M.; Kotovsky, D. A.; Caicedo, J. A.; Wilkes, R. A.; Carvalho, F. L.; Pilkey, J. T.; Ngin, T. K.; Gamerota, W. R.; Rassoul, H. K.

2017-08-01

It has been argued in the technical literature, and widely reported in the popular press, that cosmic ray air showers (CRASs) can initiate lightning via a mechanism known as relativistic runaway electron avalanche (RREA), where large numbers of high-energy and low-energy electrons can, somehow, cause the local atmosphere in a thundercloud to transition to a conducting state. In response to this claim, other researchers have published simulations showing that the electron density produced by RREA is far too small to be able to affect the conductivity in the cloud sufficiently to initiate lightning. In this paper, we compare 74 days of cosmic ray air shower data collected in north central Florida during 2013-2015, the recorded CRASs having primary energies on the order of 1016 eV to 1018 eV and zenith angles less than 38°, with Lightning Mapping Array (LMA) data, and we show that there is no evidence that the detected cosmic ray air showers initiated lightning. Furthermore, we show that the average probability of any of our detected cosmic ray air showers to initiate a lightning flash can be no more than 5%. If all lightning flashes were initiated by cosmic ray air showers, then about 1.6% of detected CRASs would initiate lightning; therefore, we do not have enough data to exclude the possibility that lightning flashes could be initiated by cosmic ray air showers.

CAMS newly detected meteor showers and the sporadic background

NASA Astrophysics Data System (ADS)

Jenniskens, P.; Nénon, Q.; Gural, P. S.; Albers, J.; Haberman, B.; Johnson, B.; Morales, R.; Grigsby, B. J.; Samuels, D.; Johannink, C.

2016-03-01

The Cameras for Allsky Meteor Surveillance (CAMS) video-based meteoroid orbit survey adds 60 newly identified showers to the IAU Working List of Meteor Showers (numbers 427, 445-446, 506-507, and part of 643-750). 28 of these are also detected in the independent SonotaCo survey. In total, 230 meteor showers and shower components are identified in CAMS data, 177 of which are detected in at least two independent surveys. From the power-law size frequency distribution of detected showers, we extrapolate that 36% of all CAMS-observed meteors originated from ∼700 showers above the N = 1 per 110,000 shower limit. 71% of mass falling to Earth from streams arrives on Jupiter-family type orbits. The transient Geminids account for another 15%. All meteoroids not assigned to streams form a sporadic background with highest detected numbers from the apex source, but with 98% of mass falling in from the antihelion source. Even at large ∼7-mm sizes, a Poynting-Robertson drag evolved population is detected, which implies that the Grün et al. collisional lifetimes at these sizes are underestimated by about a factor of 10. While these large grains survive collisions, many fade on a 104-y timescale, possibly because they disintegrate into smaller particles by processes other than collisions, leaving a more resilient population to evolve.

Neutrino astronomy with supernova neutrinos

NASA Astrophysics Data System (ADS)

Brdar, Vedran; Lindner, Manfred; Xu, Xun-Jie

2018-04-01

Modern neutrino facilities will be able to detect a large number of neutrinos from the next Galactic supernova. We investigate the viability of the triangulation method to locate a core-collapse supernova by employing the neutrino arrival time differences at various detectors. We perform detailed numerical fits in order to determine the uncertainties of these time differences for the cases when the core collapses into a neutron star or a black hole. We provide a global picture by combining all the relevant current and future neutrino detectors. Our findings indicate that in the scenario of a neutron star formation, supernova can be located with precision of 1.5 and 3.5 degrees in declination and right ascension, respectively. For the black hole scenario, sub-degree precision can be reached.

Astronaut Charles Conrad poses in shower facility in crew quarters

NASA Technical Reports Server (NTRS)

1973-01-01

Astronaut Charles Conrad Jr., Skylab 2 commander, smiles for the camera after a hot bath in the shower facility in the crew quarters of the Orbital Workshop of the Skylab 2 space station cluster in Earth orbit. In deploying the shower facility the shower curtain is pulled up from the floor and attached to the ceiling. The water comes through a push-button shower head attached to a flexible hose. Water is drawn off by a vacuum system.

Supernova Neutrino-Process and Implication in Neutrino Oscillation

NASA Astrophysics Data System (ADS)

Kajino, T.; Aoki, W.; Fujiya, W.; Mathews, G. J.; Yoshida, T.; Shaku, K.; Nakamura, K.; Hayakawa, T.

2012-08-01

We studied the supernova nucleosynthesis induced by neutrino interactions and found that several isotopes of rare elements like 7Li, 11B, 138La, 180Ta and many others are predominantly produced by the neutrino-process in core-collapse supernovae. These isotopes are strongly affected by the neutrino flavor oscillation due to the MSW (Mikheyev-Smirnov-Wolfenstein) effect. We here propose a new novel method to determine the unknown neutrino oscillation parameters, θ13 and mass hierarchy simultaneously from the supernova neutrino-process, combined with the r-process for heavy-element synthsis and the Galactic chemical evolution on light nuclei.

Fast Simulation of Electromagnetic Showers in the ATLAS Calorimeter: Frozen Showers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barberio, E.; /Melbourne U.; Boudreau, J.

2011-11-29

One of the most time consuming process simulating pp interactions in the ATLAS detector at LHC is the simulation of electromagnetic showers in the calorimeter. In order to speed up the event simulation several parametrisation methods are available in ATLAS. In this paper we present a short description of a frozen shower technique, together with some recent benchmarks and comparison with full simulation. An expected high rate of proton-proton collisions in ATLAS detector at LHC requires large samples of simulated events (Monte Carlo) to study various physics processes. A detailed simulation of particle reactions ('full simulation') in the ATLAS detectormore » is based on GEANT4 and is very accurate. However, due to complexity of the detector, high particle multiplicity and GEANT4 itself, the average CPU time spend to simulate typical QCD event in pp collision is 20 or more minutes for modern computers. During detector simulation the largest time is spend in the calorimeters (up to 70%) most of which is required for electromagnetic particles in the electromagnetic (EM) part of the calorimeters. This is the motivation for fast simulation approaches which reduce the simulation time without affecting the accuracy. Several of fast simulation methods available within the ATLAS simulation framework (standard Athena based simulation program) are discussed here with the focus on the novel frozen shower library (FS) technique. The results obtained with FS are presented here as well.« less

Measurement of the $$\\mathrm{Z}\\gamma^{*} \\to \\tau\\tau$$ cross section in pp collisions at $$\\sqrt{s} = $$ 13 TeV and validation of $$\\tau$$ lepton analysis techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, Albert M; et al.

A measurement is presented of themore » $$\\mathrm{Z}/\\gamma^{*} \\to \\tau\\tau$$ cross section in pp collisions at $$\\sqrt{s} = $$ 13 TeV, using data recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 2.3 fb$$^{-1}$$. The product of the inclusive cross section and branching fraction is measured to be $$\\sigma(\\mathrm{pp} \\to \\mathrm{Z}/\\gamma^{*}\\text{+X}) \\, \\mathcal{B}(\\mathrm{Z}/\\gamma^{*} \\to \\tau\\tau) = $$ 1848 $$\\pm$$ 12 (stat) $$\\pm$$ 67 (syst+lumi) pb, in agreement with the standard model expectation, computed at next-to-next-to-leading order accuracy in perturbative quantum chromodynamics. The measurement is used to validate new analysis techniques relevant for future measurements of $$\\tau$$ lepton production. The measurement also provides the reconstruction efficiency and energy scale for $$\\tau$$ decays to hadrons+$$\

Uncertainties in energy reconstruction of cosmic rays for ANITA III caused by differences in models of radio emission in atmospheric showers

NASA Astrophysics Data System (ADS)

Bugaev, Viatcheslav; Rauch, Brian; Schoorlemmer, Harm; Lam, Joe; Urdaneta, David; Wissel, Stephanie; Belov, Konstantin; Romero-Wolf, Andrew; Anita Collaboration

2015-04-01

The third flight of the high-altitude balloon-borne Antarctic Impulsive Transient Antenna (ANITA III) was launched on a high-altitude balloon from McMurdo, Antarctica on December 17th, 2014 and flew for 22 days. It was optimized for the measurement of impulsive radio signals from the charged component of extensive air showers initiated by ultra-high energy cosmic rays in the frequency range ~ 180 - 1200 MHz. In addition it is designed to detect radio impulses initiated by high-energy neutrinos interacting in the Antarctic ice, which was the primary objective of the first two ANITA flights. Based on an extensive set of Monte Carlo simulations of radio emissions from cosmic rays (CR) with the ZHAireS and CoREAS simulation packages, we estimate uncertainties in the electric fields at the payload due to different models used in the two packages. The uncertainties in the emission are then propagated through an algorithm for energy reconstruction of individual CR showers to assess uncertainties in the energy reconstruction. We also discuss optimization of this algorithm. This research is supported by NASA under Grant # NNX11AC49G.

Polarized radio emission from extensive air showers measured with LOFAR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schellart, P.; Buitink, S.; Corstanje, A.

2014-10-01

We present LOFAR measurements of radio emission from extensive air showers. We find that this emission is strongly polarized, with a median degree of polarization of nearly 99%, and that the angle between the polarization direction of the electric field and the Lorentz force acting on the particles, depends on the observer location in the shower plane. This can be understood as a superposition of the radially polarized charge-excess emission mechanism, first proposed by Askaryan and the geomagnetic emission mechanism proposed by Kahn and Lerche. We calculate the relative strengths of both contributions, as quantified by the charge-excess fraction, formore » 163 individual air showers. We find that the measured charge-excess fraction is higher for air showers arriving from closer to the zenith. Furthermore, the measured charge-excess fraction also increases with increasing observer distance from the air shower symmetry axis. The measured values range from (3.3± 1.0)% for very inclined air showers at 25 m to (20.3± 1.3)% for almost vertical showers at 225 m. Both dependencies are in qualitative agreement with theoretical predictions.« less

Modelling of radio emission from cosmic ray air showers

NASA Astrophysics Data System (ADS)

Ludwig, Marianne

2011-06-01

Cosmic rays entering the Earth's atmosphere induce extensive air showers consisting of up to billions of secondary particles. Among them, a multitude of electrons and positrons are generated. These get deflected in the Earth's magnetic field, creating time-varying transverse currents. Thereby, the air shower emits coherent radiation in the MHz frequency range measured by radio antenna arrays on the ground such as LOPES at the KIT. This detection method provides a possibility to study cosmic rays with energies above 1017 eV. At this time, the radio technique undergoes the change from prototype experiments to large scale application. Thus, a detailed understanding of the radio emission process is needed more than ever. Before starting this work, different models made conflicting predictions on the pulse shape and the amplitude of the radio signal. It turned out that a radiation component caused by the variation of the number of charged particles within the air shower was missed in several models. The Monte Carlo code REAS2 superposing the radiation of the individual air shower electrons and positrons was one of those. At this time, it was not known how to take the missing component into account. For REAS3, we developed and implemented the endpoint formalism, a universal approach, to calculate the radiation from each single particle. For the first time, we achieve a good agreement between REAS3 and MGMR, an independent and completely different simulation approach. In contrast to REAS3, MGMR is based on a macroscopic approach and on parametrisations of the air shower. We studied the differences in the underlying air shower models to explain the remaining deviations. For comparisons with LOPES data, we developed a new method which allows "top-down" simulations of air showers. From this, we developed an air shower selection criterion based on the number of muons measured with KASCADE to take shower-to-shower fluctuations for a single event analysis into account. With

Neutrino experiments

DOE PAGES

Lesko, K. T.

2004-02-24

This review examines a wide variety of experiments investigating neutrino interactions and neutrino properties from a variety of neutrino sources. We have witnessed remarkable progress in the past two years in settling long standing problems in neutrino physics and uncovering the first evidence for physics beyond the Standard Model in nearly 30 years. Here this paper briefly reviews this recent progress in the field of neutrino physics and highlights several significant experimental arenas and topics for the coming decade of particular interest. These highlighted experiments include the precision determination of oscillation parameters including θ 13, θ 12, Δm 12 2more » and Δm 23 2 as well as a number of fundamental properties are likely to be probed included nature of the neutrino (Majorana versus Dirac), the number of neutrino families and the neutrino’s absolute mass.« less

Neutrino factory

DOE PAGES

Bogomilov, M.; Matev, R.; Tsenov, R.; ...

2014-12-08

The properties of the neutrino provide a unique window on physics beyond that described by the standard model. The study of subleading effects in neutrino oscillations, and the race to discover CP-invariance violation in the lepton sector, has begun with the recent discovery that theta(13) > 0. The measured value of theta(13) is large, emphasizing the need for a facility at which the systematic uncertainties can be reduced to the percent level. The neutrino factory, in which intense neutrino beams are produced from the decay of muons, has been shown to outperform all realistic alternatives and to be capable ofmore » making measurements of the requisite precision. Its unique discovery potential arises from the fact that only at the neutrino factory is it practical to produce high-energy electron (anti) neutrino beams of the required intensity. This paper presents the conceptual design of the neutrino factory accelerator facility developed by the European Commission Framework Programme 7 EURO nu. Design Study consortium. EURO nu coordinated the European contributions to the International Design Study for the Neutrino Factory (the IDS-NF) collaboration. The EURO nu baseline accelerator facility will provide 10(21) muon decays per year from 12.6 GeV stored muon beams serving a single neutrino detector situated at a source-detector distance of between 1 500 km and 2 500 km. A suite of near detectors will allow definitive neutrino-scattering experiments to be performed.« less

Low-energy neutrinos

NASA Astrophysics Data System (ADS)

Ludhova, Livia

2016-05-01

There exist several kinds of sources emitting neutrinos in the MeV energy range. These low-energy neutrinos from different sources can be often detected by the same multipurpose detectors. The status-of-art of the field of solar neutrinos, geoneutrinos, and the search for sterile neutrino with artificial neutrino sources is provided here; other neutrino sources, as for example reactor or high-energy neutrinos, are described elsewhere. For each of these three fields, the present-day motivation and open questions, as well as the latest experimental results and future perspectives are discussed.

Open issues in hadronic interactions for air showers

NASA Astrophysics Data System (ADS)

Pierog, Tanguy

2017-06-01

In detailed air shower simulations, the uncertainty in the prediction of shower observables for different primary particles and energies is currently dominated by differences between hadronic interaction models. With the results of the first run of the LHC, the difference between post-LHC model predictions has been reduced to the same level as experimental uncertainties of cosmic ray experiments. At the same time new types of air shower observables, like the muon production depth, have been measured, adding new constraints on hadronic models. Currently no model is able to consistently reproduce all mass composition measurements possible within the Pierre Auger Observatory for instance. Comparing the different models, and with LHC and cosmic ray data, we will show that the remaining open issues in hadronic interactions in air shower development are now in the pion-air interactions and in nuclear effects.

Neutrino Oscillation Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kayser, Boris

2012-06-01

To complement the neutrino-physics lectures given at the 2011 International School on Astro Particle Physics devoted to Neutrino Physics and Astrophysics (ISAPP 2011; Varenna, Italy), at the 2011 European School of High Energy Physics (ESHEP 2011; Cheila Gradistei, Romania), and, in modified form, at other summer schools, we present here a written description of the physics of neutrino oscillation. This description is centered on a new way of deriving the oscillation probability. We also provide a brief guide to references relevant to topics other than neutrino oscillation that were covered in the lectures. Neutrinos and photons are by far themore » most abundant elementary particles in the universe. Thus, if we would like to comprehend the universe, we must understand the neutrinos. Of course, studying the neutrinos is challenging, since the only known forces through which these electrically-neutral leptons interact are the weak force and gravity. Consequently, interactions of neutrinos in a detector are very rare events, so that very large detectors and intense neutrino sources are needed to make experiments feasible. Nevertheless, we have confirmed that the weak interactions of neutrinos are correctly described by the Standard Model (SM) of elementary particle physics. Moreover, in the last 14 years, we have discovered that neutrinos have nonzero masses, and that leptons mix. These discoveries have been based on the observation that neutrinos can change from one 'flavor' to another - the phenomenon known as neutrino oscillation. We shall explain the physics of neutrino oscillation, deriving the probability of oscillation in a new way. We shall also provide a very brief guide to references that can be used to study some major neutrino-physics topics other than neutrino oscillation.« less

Regular and transitory showers of comet C/1979 Y1 (Bradfield)

NASA Astrophysics Data System (ADS)

Hajduková, M.; Neslušan, L.

2017-09-01

Aims: We intend to map the whole meteor complex of the long-period comet C/1979 Y1 (Bradfield), which is a proposed parent body of the July Pegasids, No. 175 in the list of meteor showers established by the Meteor Data Center (MDC) of the International Astronomical Union (IAU). Methods: For five perihelion passages of the parent comet in the past, we model associated theoretical stream, its parts, each consisting of 10 000 test particles, and follow the dynamical evolution of these parts up to the present. Subsequently, we analyze the mean orbital characteristics of those particles of the parts that approach the Earth's orbit and, thus, create a shower or showers. The showers are compared with their observed counterparts separated from photographic, radio, and several video databases. Results: The modeled stream of C/1979 Y1 approaches the Earth's orbit in two filaments that correspond to two regular (annual) showers. We confirm the generic relationship between the studied parent comet and 175 July Pegasids. The other predicted shower is a daytime shower with the mean radiant situated symmetrically to the July Pegasids with respect to the apex of the Earth's motion. This shower is not in the IAU MDC list, but we separated it from the Cameras-for-Allsky-Meteor-Surveillance (CAMS) and SonotaCo video data as a new shower. We suggest naming it α-Microscopiids. The stronger influence of the Poynting-Robertson drag deflects the stream away from the Earth's orbit in those sections that correspond to the July Pegasids and the predicted daytime shower, but it makes the stream cross the Earth's orbit in other sections. Corresponding showers are, however, only expected to survive during a limited period and to consist of particles of sizes in a narrow interval. We identified one of these "transitory" filaments to the 104 γ-Bootids in the IAU MDC list of meteor showers.

The SHiP experiment at CERN SPS

NASA Astrophysics Data System (ADS)

Di Crescenzo, A.; SHiP Collaboration

2016-01-01

SHiP is a new general purpose fixed target facility, whose Technical Proposal has been recently submitted to the CERN SPS Committee. In its initial phase, the 400GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2×1020 pot in 5years. A dedicated detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c2. The beam dump is also an ideal source of tau neutrinos, the less known particle in the Standard Model. Another dedicated detector, based on the Emulsion Cloud Chamber technology already used in the OPERA experiment, will allow to perform for the first time measurements of the tau neutrino deep inelastic scattering cross section. Tau neutrinos will be distinguished from tau anti-neutrinos, thus providing the first observation of the tau anti-neutrino.

Phenomenological characteristic of the electron component in gamma-quanta initiated showers

NASA Technical Reports Server (NTRS)

Nikolsky, S. I.; Stamenov, J. N.; Ushev, S. Z.

1985-01-01

The phenomenological characteristics of the electron component in showers initiated by primary gamma-quanta were analyzed on the basis of the Tien Shan experimental data. It is shown that the lateral distribution of the electrons ion gamma-quanta initiated showers can be described with NKG - function with age parameters bar S equals 0, 76 plus or minus 0, 02, different from the same parameter for normal showers with the same size bar S equals 0, 85 plus or minus 0, 01. The lateral distribution of the correspondent electron energy flux in gamma-quanta initiated showers is steeper as in normal cosmic ray showers.

Neutrino Physics

DOE R&D Accomplishments Database

Lederman, L. M.

1963-01-09

The prediction and verification of the neutrino are reviewed, together with the V A theory for its interactions (particularly the difficulties with the apparent existence of two neutrinos and the high energy cross section). The Brookhaven experiment confirming the existence of two neutrinos and the cross section increase with momentum is then described, and future neutrino experiments are considered. (D.C.W.)

Matter-neutrino resonance in a multiangle neutrino bulb model

NASA Astrophysics Data System (ADS)

Vlasenko, Alexey; McLaughlin, G. C.

2018-04-01

Simulations of neutrino flavor evolution in compact merger environments have shown that neutrino flavor, and hence nucleosynthesis, can be strongly affected by the presence of matter-neutrino resonances (MNRs), where there is a cancelation between the matter and the neutrino potential. Simulations performed thus far follow flavor evolution along a single neutrino trajectory, but self-consistency requires all trajectories to be treated simultaneously, and it has not been known whether MNR phenomena would still occur in multiangle models. In this paper, we present the first fully multi-angle calculations of MNR. We find that familiar MNR phenomena, where neutrinos transform to a greater extent than anti-neutrinos and a feedback mechanism maintains the cancellation between the matter and neutrino potential, still occurs for a subset of angular bins, although the flavor transformation is not as efficient as in the single-angle case. In addition, we find other types of flavor transformation that are not seen in single-angle simulations. These flavor transformation phenomena appear to be robust and are present for a wide range of model parameters, as long as an MNR is present. Although computational constraints currently limit us to models with spherical symmetry, our results suggest that the presence of an MNR generally leads to large-scale neutrino flavor evolution in multiangle systems.

Near-atomic model of microtubule-tau interactions.

PubMed

Kellogg, Elizabeth H; Hejab, Nisreen M A; Poepsel, Simon; Downing, Kenneth H; DiMaio, Frank; Nogales, Eva

2018-06-15

Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer's disease. It is unclear which tau residues are crucial for tau-MT interactions, where tau binds on MTs, and how it stabilizes them. We used cryo-electron microscopy to visualize different tau constructs on MTs and computational approaches to generate atomic models of tau-tubulin interactions. The conserved tubulin-binding repeats within tau adopt similar extended structures along the crest of the protofilament, stabilizing the interface between tubulin dimers. Our structures explain the effect of phosphorylation on MT affinity and lead to a model of tau repeats binding in tandem along protofilaments, tethering together tubulin dimers and stabilizing polymerization interfaces. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy.

PubMed

Espíndola, Sonia Lorena; Damianich, Ana; Alvarez, Rodrigo Javier; Sartor, Manuela; Belforte, Juan Emilio; Ferrario, Juan Esteban; Gallo, Jean-Marc; Avale, María Elena

2018-04-17

The microtubule-associated protein tau regulates myriad neuronal functions, such as microtubule dynamics, axonal transport and neurite outgrowth. Tauopathies are neurodegenerative disorders characterized by the abnormal metabolism of tau, which accumulates as insoluble neuronal deposits. The adult human brain contains equal amounts of tau isoforms with three (3R) or four (4R) repeats of microtubule-binding domains, derived from the alternative splicing of exon 10 (E10) in the tau transcript. Several tauopathies are associated with imbalances of tau isoforms, due to splicing deficits. Here, we used a trans-splicing strategy to shift the inclusion of E10 in a mouse model of tauopathy that produces abnormal excess of 3R tau. Modulating the 3R/4R ratio in the prefrontal cortex led to a significant reduction of pathological tau accumulation concomitant with improvement of neuronal firing and reduction of cognitive impairments. Our results suggest promising potential for the use of RNA reprogramming in human neurodegenerative diseases. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Momentum conservation and unitarity in parton showers and NLL resummation

DOE PAGES

Höche, Stefan; Reichelt, Daniel; Siegert, Frank

2018-01-23

We present a systematic study of differences between NLL resummation and parton showers. We first construct a Markovian Monte-Carlo algorithm for resummation of additive observables in electron-positron annihilation. Approximations intrinsic to the pure NLL result are then removed, in order to obtain a traditional, momentum and probability conserving parton shower based on the coherent branching formalism. The impact of each approximation is studied, and an overall comparison is made between the parton shower and pure NLL resummation. Differences compared to modern parton-shower algorithms formulated in terms of color dipoles are analyzed.

Meteoroid Environment Modeling: The Meteoroid Engineering Model and Shower Forecasting

NASA Technical Reports Server (NTRS)

Moorhead, Althea V.

2017-01-01

The meteoroid environment is often divided conceptually into meteor showers and the sporadic meteor background. It is commonly but incorrectly assumed that meteoroid impacts primarily occur during meteor showers; instead, the vast majority of hazardous meteoroids belong to the sporadic complex. Unlike meteor showers, which persist for a few hours to a few weeks, sporadic meteoroids impact the Earth's atmosphere and spacecraft throughout the year. The Meteoroid Environment Office (MEO) has produced two environment models to handle these cases: the Meteoroid Engineering Model (MEM) and an annual meteor shower forecast. The sporadic complex, despite its year-round activity, is not isotropic in its directionality. Instead, their apparent points of origin, or radiants, are organized into groups called "sources". The speed, directionality, and size distribution of these sporadic sources are modeled by the Meteoroid Engineering Model (MEM), which is currently in its second major release version (MEMR2) [Moorhead et al., 2015]. MEM provides the meteoroid flux relative to a user-provided spacecraft trajectory; it provides the total flux as well as the flux per angular bin, speed interval, and on specific surfaces (ram, wake, etc.). Because the sporadic complex dominates the meteoroid flux, MEM is the most appropriate model to use in spacecraft design. Although showers make up a small fraction of the meteoroid environment, they can produce significant short-term enhancements of the meteoroid flux. Thus, it can be valuable to consider showers when assessing risks associated with vehicle operations that are brief in duration. To assist with such assessments, the MEO issues an annual forecast that reports meteor shower fluxes as a function of time and compares showers with the time-averaged total meteoroid flux. This permits missions to do quick assessments of the increase in risk posed by meteor showers. Section II describes MEM in more detail and describes our current efforts

Meteoroid Environment Modeling: the Meteoroid Engineering Model and Shower Forecasting

NASA Technical Reports Server (NTRS)

Moorhead, Althea V.

2017-01-01

INTRODUCTION: The meteoroid environment is often divided conceptually into meteor showers and the sporadic meteor background. It is commonly but incorrectly assumed that meteoroid impacts primarily occur during meteor showers; instead, the vast majority of hazardous meteoroids belong to the sporadic complex. Unlike meteor showers, which persist for a few hours to a few weeks, sporadic meteoroids impact the Earth's atmosphere and spacecraft throughout the year. The Meteoroid Environment Office (MEO) has produced two environment models to handle these cases: the Meteoroid Engineering Model (MEM) and an annual meteor shower forecast. The sporadic complex, despite its year-round activity, is not isotropic in its directionality. Instead, their apparent points of origin, or radiants, are organized into groups called "sources". The speed, directionality, and size distribution of these sporadic sources are modeled by the Meteoroid Engineering Model (MEM), which is currently in its second major release version (MEMR2) [Moorhead et al., 2015]. MEM provides the meteoroid flux relative to a user-provided spacecraft trajectory; it provides the total flux as well as the flux per angular bin, speed interval, and on specific surfaces (ram, wake, etc.). Because the sporadic complex dominates the meteoroid flux, MEM is the most appropriate model to use in spacecraft design. Although showers make up a small fraction of the meteoroid environment, they can produce significant short-term enhancements of the meteoroid flux. Thus, it can be valuable to consider showers when assessing risks associated with vehicle operations that are brief in duration. To assist with such assessments, the MEO issues an annual forecast that reports meteor shower fluxes as a function of time and compares showers with the time-averaged total meteoroid flux. This permits missions to do quick assessments of the increase in risk posed by meteor showers.

A 20 GeVs transparent neutrino astronomy from the North Pole?

NASA Astrophysics Data System (ADS)

Fargion, D.; D'Armiento, D.

2011-03-01

Muon neutrino astronomy is drown within a polluted atmospheric neutrino noise: indeed recent ICECUBE neutrino records at (TeVs) couldn't find any muon neutrino point source [R. Abbasi et al. (IceCube Collaboration), arXiv:1010.3980v1] being blurred by such a noisy sky. However at 24 GeV energy atmospheric muon neutrinos, while rising vertically along the terrestrial diameter, should disappear (or be severely depleted) while converting into tau flavor: any rarest vertical E≃12 GeV muon track at South Pole Deep Core volume, pointing back to North Pole, might be tracing mostly a noise-free astrophysical signal. The corresponding Deep Core 6 - 7 - 8 - 9 channels trigger maybe point in those directions and inside that energy range without much background. Analogous ν suppression do not occur so efficiently elsewhere (as SuperKamiokande) because of a much smaller volume, an un-ability to test the muon birth place, its length, its expected energy. Also the smearing of the terrestrial rotation makes Deep Core ideal: along the South-North Pole the solid angle is almost steady, the flavor ν↦ν conversion persist while the Earth is spinning around the stable poles-axis. Therefore Deep Core detector at South Pole, may scan at E≃18-27 GeV energy windows, into a narrow vertical cone Δθ≃30° for a novel ν, ν astronomy almost noise-free, pointing back toward the North Pole. Unfortunately muon (at E≃12 GeV) trace their arrival direction mostly spread around an unique string in a zenith-cone solid angle. To achieve also an azimuth angular resolution a two string detection at once is needed. Therefore the doubling of the Deep Core string number, (two new arrays of six string each, achieving an average detection distance of 36.5 m), is desirable, leading to a larger Deep Core detection mass (more than double) and a sharper zenith and azimuth angular resolution by two-string vertical axis detection. Such an improvement may show a noise free (at least factor ten) muon

Non-unitarity, sterile neutrinos, and non-standard neutrino interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blennow, Mattias; Coloma, Pilar; Fernandez-Martinez, Enrique

The simplest Standard Model extension to explain neutrino masses involves the addition of right-handed neutrinos. At some level, this extension will impact neutrino oscillation searches. In this work we explore the differences and similarities between the case in which these neutrinos are kinematically accessible (sterile neutrinos) or not (mixing matrix non-unitarity). We clarify apparent inconsistencies in the present literature when using different parametrizations to describe these effects and recast both limits in the popular neutrino non-standard interaction (NSI) formalism. We find that, in the limit in which sterile oscillations are averaged out at the near detector, their effects at themore » far detector coincide with non-unitarity at leading order, even in presence of a matter potential. We also summarize the present bounds existing in both limits and compare them with the expected sensitivities of near future facilities taking the DUNE proposal as a benchmark. We conclude that non-unitarity effects are too constrained to impact present or near future neutrino oscillation facilities but that sterile neutrinos can play an important role at long baseline experiments. As a result, the role of the near detector is also discussed in detail.« less

Non-unitarity, sterile neutrinos, and non-standard neutrino interactions

DOE PAGES

Blennow, Mattias; Coloma, Pilar; Fernandez-Martinez, Enrique; ...

2017-04-27

The simplest Standard Model extension to explain neutrino masses involves the addition of right-handed neutrinos. At some level, this extension will impact neutrino oscillation searches. In this work we explore the differences and similarities between the case in which these neutrinos are kinematically accessible (sterile neutrinos) or not (mixing matrix non-unitarity). We clarify apparent inconsistencies in the present literature when using different parametrizations to describe these effects and recast both limits in the popular neutrino non-standard interaction (NSI) formalism. We find that, in the limit in which sterile oscillations are averaged out at the near detector, their effects at themore » far detector coincide with non-unitarity at leading order, even in presence of a matter potential. We also summarize the present bounds existing in both limits and compare them with the expected sensitivities of near future facilities taking the DUNE proposal as a benchmark. We conclude that non-unitarity effects are too constrained to impact present or near future neutrino oscillation facilities but that sterile neutrinos can play an important role at long baseline experiments. As a result, the role of the near detector is also discussed in detail.« less

New neutrino physics and the altered shapes of solar neutrino spectra

NASA Astrophysics Data System (ADS)

Lopes, Ilídio

2017-01-01

Neutrinos coming from the Sun's core have been measured with high precision, and fundamental neutrino oscillation parameters have been determined with good accuracy. In this work, we estimate the impact that a new neutrino physics model, the so-called generalized Mikheyev-Smirnov-Wolfenstein (MSW) oscillation mechanism, has on the shape of some of leading solar neutrino spectra, some of which will be partially tested by the next generation of solar neutrino experiments. In these calculations, we use a high-precision standard solar model in good agreement with helioseismology data. We found that the neutrino spectra of the different solar nuclear reactions of the pp chains and carbon-nitrogen-oxygen cycle have quite distinct sensitivities to the new neutrino physics. The He P and 8B neutrino spectra are the ones in which their shapes are more affected when neutrinos interact with quarks in addition to electrons. The shapes of the 15O and 17F neutrino spectra are also modified, although in these cases the impact is much smaller. Finally, the impact in the shapes of the P P and 13N neutrino spectra is practically negligible.

High energy hadrons in air shower cores at mountain altitude

DOE Office of Scientific and Technical Information (OSTI.GOV)

van Staa, R.; Aschenbach, B.; Boehm, E.

1974-01-01

At the Pic du Midi (730 g cm/sup -2/) in France an air shower array has been operated to study high-energy hadrons in air shower cores. The array consists of 13 scintillation counters of 0.25 mi each and a 14 mi high energy hadron detector. 2050 showers please delete the above abstract no 21733====

Limiting neutrino magnetic moments with Borexino Phase-II solar neutrino data

NASA Astrophysics Data System (ADS)

Agostini, M.; Altenmüller, K.; Appel, S.; Atroshchenko, V.; Bagdasarian, Z.; Basilico, D.; Bellini, G.; Benziger, J.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Caprioli, S.; Carlini, M.; Cavalcante, P.; Chepurnov, A.; Choi, K.; Collica, L.; D'Angelo, D.; Davini, S.; Derbin, A.; Ding, X. F.; Di Ludovico, A.; Di Noto, L.; Drachnev, I.; Fomenko, K.; Formozov, A.; Franco, D.; Froborg, F.; Gabriele, F.; Galbiati, C.; Ghiano, C.; Giammarchi, M.; Goretti, A.; Gromov, M.; Guffanti, D.; Hagner, C.; Houdy, T.; Hungerford, E.; Ianni, Aldo; Ianni, Andrea; Jany, A.; Jeschke, D.; Kobychev, V.; Korablev, D.; Korga, G.; Kryn, D.; Laubenstein, M.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Lukyanchenko, L.; Machulin, I.; Manuzio, G.; Marcocci, S.; Martyn, J.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Muratova, V.; Neumair, B.; Oberauer, L.; Opitz, B.; Orekhov, V.; Ortica, F.; Pallavicini, M.; Papp, L.; Penek, Ã.-.; Pilipenko, N.; Pocar, A.; Porcelli, A.; Ranucci, G.; Razeto, A.; Re, A.; Redchuk, M.; Romani, A.; Roncin, R.; Rossi, N.; Schönert, S.; Semenov, D.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Stokes, L. F. F.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Thurn, J.; Toropova, M.; Unzhakov, E.; Vishneva, A.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Weinz, S.; Wojcik, M.; Wurm, M.; Yokley, Z.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.; Borexino Collaboration

2017-11-01

A search for the solar neutrino effective magnetic moment has been performed using data from 1291.5 days exposure during the second phase of the Borexino experiment. No significant deviations from the expected shape of the electron recoil spectrum from solar neutrinos have been found, and a new upper limit on the effective neutrino magnetic moment of μνeff<2.8×10 -11 μB at 90% C.L. has been set using constraints on the sum of the solar neutrino fluxes implied by the radiochemical gallium experiments. Using the limit for the effective neutrino moment, new limits for the magnetic moments of the neutrino flavor states, and for the elements of the neutrino magnetic moments matrix for Dirac and Majorana neutrinos, are derived.

Measuring B{sup {+-}}{yields}{tau}{sup {+-}}{nu} and B{sub c}{sup {+-}}{yields}{tau}{sup {+-}}{nu} at the Z peak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akeroyd, A. G.; Chen, C.H.; National Center for Theoretical Sciences, Taiwan

2008-06-01

The measurement of B{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} at the B factories provides important constraints on the parameter tan{beta}/m{sub H{sup {+-}}} in the context of models with two Higgs doublets. Limits on this decay from e{sup +}e{sup -} collisions at the Z peak were sensitive to the sum of B{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} and B{sub c}{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}}. Because of the possibly sizeable contribution from B{sub c}{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} we suggest that a signal for this combination might be observed if the CERN LEP L3 Collaboration used its total data of {approx}3.6x10{sup 6} hadronic decays of the Z boson.more » Moreover, we point out that a future linear collider operating at the Z peak (Giga Z option) could constrain tan{beta}/m{sub H{sup {+-}}} from the sum of these processes with a precision comparable to that anticipated at proposed high luminosity B factories from B{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} alone.« less

Search for sterile neutrino oscillations in muon neutrino disappearance at MINOS/MINOS+

NASA Astrophysics Data System (ADS)

Todd, Jacob; Minos+ Collaboration

2017-01-01

A wide variety of neutrino oscillation phenomena are well-described by the standard three-flavour neutrino model, but some anomalies exist. The LSND and MiniBooNE experiments have measured electron antineutrino appearance in excess of standard oscillation predictions, which points to the possibility of a sterile neutrino with higher mass than the presently known states. MINOS, a two-detector, long-baseline neutrino oscillation experiment, was optimized for the measurement of muon neutrino disappearance in the NuMI neutrino beam. A sterile neutrino responsible for the LSND and MiniBooNE excesses would cause distortions in the charged current and neutral current MINOS spectra, which permits the search for sterile neutrinos at MINOS. In close collaboration with the Daya Bay reactor neutrino experiment, MINOS has placed strong constraints on the sterile neutrino parameter space for a model with one additional sterile neutrino. Further, the extension of data collection with MINOS+, which samples the NuMI beam in a medium energy configuration, markedly increases the sensitivity of the combined MINOS and MINOS+ sample to a 3+1-flavour sterile neutrino model.

A search for muon neutrino to electron neutrino oscillation mediated by sterile neutrinos in MINOS+

NASA Astrophysics Data System (ADS)

Germani, Stefano; Schreckenberger, Adam P.

2017-09-01

The MINOS experiment made precision measurements of the neutrino oscillation parameters that are governed by the atmospheric mass-squared splitting. These measurements were made with data that were collected while the NuMI muon neutrino beam operated in a low energy mode that peaks around 3 GeV. Today the NuMI beam is running with a higher energy mode that produces a neutrino energy spectrum that peaks around 7 GeV, allowing the MINOS+ experiment to probe neutrino oscillation phenomena that could potentially be governed by a fourth mass-squared splitting. If observed, the presence of a fourth mass-squared splitting would be compelling evidence for a sterile neutrino state. In this analysis, we will present the results of a search for νµ → νe oscillation mediated by sterile neutrinos in MINOS+. The results will be contrasted against the measurements made by the LSND experiment.

Tau regulates the subcellular localization of calmodulin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barreda, Elena Gomez de; Avila, Jesus, E-mail: javila@cbm.uam.es; CIBER de Enfermedades Neurodegenerativas, 28031 Madrid

Highlights: {yields} In this work we have tried to explain how a cytoplasmic protein could regulate a cell nuclear function. We have tested the role of a cytoplasmic protein (tau) in regulating the expression of calbindin gene. We found that calmodulin, a tau-binding protein with nuclear and cytoplasmic localization, increases its nuclear localization in the absence of tau. Since nuclear calmodulin regulates calbindin expression, a decrease in nuclear calmodulin, due to the presence of tau that retains it at the cytoplasm, results in a change in calbindin expression. -- Abstract: Lack of tau expression in neuronal cells results in amore » change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.« less

EUSO-SPB2: Second Generation Extreme Universe Space Observatory on a SuperPressure Balloon, Colorado School of Mines Co-I

NASA Astrophysics Data System (ADS)

Wiencke, Lawrence

This is a Co-Investigator Proposal for EUSO-SPB2, second generation Extreme Universe Space Observatory on a Super-Pressure Balloon. The PI is Angela V. Olinto (University of Chicago) Co-Is at Marshall Space Flight Center (Institution PI, M. Christl), Colorado School of Mines (Institution PI, L.Wiencke), University of Alabama Huntsville (Institution PI, P. Reardon), and Lehman College, CUNY (Institution PI, L. Anchordoqui). We propose to design, build, deploy, and publish the scientific results of a second generation of the Extreme Universe Space Observatory (EUSO), to be flown aboard a Super-Pressure Balloon (SBP). EUSO-SPB2 will monitor the night sky of the Southern hemisphere to study cosmic rays of very high to ultrahigh energies and pioneer the search for cosmogenic tau neutrinos from space. EUSO-SPB2 will be the first instrument to observe Cherenkov light from extensive airshowers high in the atmosphere. EUSO-SPB2 will observe a large sample of cosmic rays from 0.1 to 1 EeV with the Cherenkov technique and will discriminate among the Cherenkov profiles of primary protons, heavy nuclei, and photons. It will also characterize the background for upward going showers initiated by the decay of tau leptons, which are expected to be produced by Earth-skimming tau neutrinos. A coincidence veto will be developed for EUSO-SPB2 so it can characterize the background for Cherenkov signals from the neutrino produced tau leptons. EUSO-SPB2 will also use fluorescence observations to measure, for the first time, the evolution of nearly horizontal high altitude extensive air showers, which develop at the nearly constant low-density atmosphere. Such measurements will provide a unique channel to probe hadronic interaction models at ultrahigh energies, and may elucidate the reason why ultrahigh-energy cosmic ray (UHECR) showers observed by ground-based detectors contain more muons than expected from hadronic interaction models. EUSO-SPB2 is a pathfinder for the more ambitious

EUSO-SPB2: Second Generation Extreme Universe Space Observatory on a SuperPressure Balloon

NASA Astrophysics Data System (ADS)

Olinto, Angela

This is the lead Institution Co-Investigator Proposal for EUSO-SPB2, second generation Extreme Universe Space Observatory on a Super-Pressure Balloon. It is led by PI Angela V. Olinto at the University of Chicago with Co-Is at Marshall Space Flight Center (Institution PI, Mark Christl), Colorado School of Mines (Institution PI, Lawrence Wiencke), University of Alabama Huntsville (Institution PI, Patrick Reardon), and Lehman College, CUNY (Institution PI, Luis Anchordoqui). We propose to design, build, deploy, and publish the scientific results of a second generation of the Extreme Universe Space Observatory (EUSO), to be flown aboard a Super-Pressure Balloon (SBP). EUSO-SPB2 will monitor the night sky of the Southern hemisphere to study cosmic rays of very high to ultrahigh energies and pioneer the search for cosmogenic tau neutrinos from space. EUSO-SPB2 will be the first instrument to observe Cherenkov light from extensive airshowers high in the atmosphere. EUSO-SPB2 will observe a large sample of cosmic rays from 0.1 to 1 EeV with the Cherenkov technique and will discriminate among the Cherenkov profiles of primary protons, heavy nuclei, and photons. It will also characterize the background for upward going showers initiated by the decay of tau leptons, which are expected to be produced by Earth-skimming tau neutrinos. A coincidence veto will be developed for EUSO-SPB2 so it can characterize the background for Cherenkov signals from the neutrino produced tau leptons. EUSO-SPB2 will also use fluorescence observations to measure, for the first time, the evolution of nearly horizontal high altitude extensive air showers, which develop at the nearly constant low-density atmosphere. Such measurements will provide a unique channel to probe hadronic interaction models at ultrahigh energies, and may elucidate the reason why ultrahigh-energy cosmic ray (UHECR) showers observed by ground-based detectors contain more muons than expected from hadronic interaction models

EUSO-SPB2: Second Generation Extreme Universe Space Observatory (EUSO) on Board a Super-Pressure Balloon (SPB)

NASA Astrophysics Data System (ADS)

Anchordoqui, Luis

This is a Co-Investigator Proposal for EUSO-SPB2 being led by PI Angela V. Olinto at the University of Chicago as the lead Institution. This is the Lehman College (City University of New York) Task Statement. We propose to design, build, deploy, and publish the scientific results of a second generation of the Extreme Universe Space Observatory (EUSO), to be flown aboard a Super-Pressure Balloon (SBP). EUSO-SPB2 will monitor the night sky of the Southern hemisphere to study cosmic rays of very high to ultrahigh energies and pioneer the search for cosmogenic tau neutrinos from space. EUSO-SPB2 will be the first instrument to observe Cherenkov light from extensive airshowers high in the atmosphere. EUSO-SPB2 will observe a large sample of cosmic rays from 0.1 to 1 EeV with the Cherenkov technique and will discriminate among the Cherenkov profiles of primary protons, heavy nuclei, and photons. It will also characterize the background for upward going showers initiated by the decay of tau leptons, which are expected to be produced by Earth-skimming tau neutrinos. A coincidence veto will be developed for EUSO-SPB2 so it can characterize the background for Cherenkov signals from the neutrino produced tau leptons. EUSO-SPB2 will also use fluorescence observations to measure, for the first time, the evolution of nearly horizontal high altitude extensive air showers, which develop at the nearly constant low-density atmosphere. Such measurements will provide a unique channel to probe hadronic interaction models at ultrahigh energies, and may elucidate the reason why ultrahigh-energy cosmic ray (UHECR) showers observed by ground-based detectors contain more muons than expected from hadronic interaction models. EUSO-SPB2 is a pathfinder for the more ambitious space-based measurements by the Probe Of Extreme Multi-Messenger Astrophysics (POEMMA), currently proposed for a NASA design study. POEMMA will combine the well-developed Orbiting Wide-field Light-collectors (OWL) concept

EUSO-SPB2: second generation Extreme Universe Space Observatory (EUSO) on board a Super-Pressure Balloon (SPB), NASA/MSFC Co-I

NASA Astrophysics Data System (ADS)

Christl, Mark

This is a Co-Investigator Proposal for EUSO-SPB2 being led by PI Angela V. Olinto at the University of Chicago as the lead Institution. This is the NASA/Marshall Space Flight Center Task Statement. We propose to design, build, deploy, and publish the scientific results of a second generation of the Extreme Universe Space Observatory (EUSO), to be flown aboard a Super-Pressure Balloon (SPB). EUSO-SPB2 will monitor the night sky of the Southern hemisphere to study cosmic rays of very high to ultrahigh energies and pioneer the search for cosmogenic tau neutrinos from space. EUSO-SPB2 will be the first instrument to observe Cherenkov light from extensive airshowers high in the atmosphere. EUSO-SPB2 will observe a large sample of cosmic rays from 0.1 to 1 EeV with the Cherenkov technique and will discriminate among the Cherenkov profiles of primary protons, heavy nuclei, and photons. It will also characterize the background for upward going showers initiated by the decay of tau leptons, which are expected to be produced by Earth-skimming tau neutrinos. A fast coincidence test will be developed for EUSO-SPB2 so it can characterize the background for Cherenkov signals from the neutrino produced tau leptons. EUSO-SPB2 will also use fluorescence observations to measure, for the first time, the evolution of nearly horizontal high altitude extensive air showers, which develop at the nearly constant low-density atmosphere. Such measurements will provide a unique channel to probe hadronic interaction models at ultrahigh energies, and may elucidate the reason why ultrahigh-energy cosmic ray (UHECR) showers observed by ground-based detectors contain more muons than expected from hadronic interaction models. EUSO-SPB2 is a pathfinder for the more ambitious space-based measurements by the Probe Of Extreme Multi-Messenger Astrophysics (POEMMA), currently proposed for a NASA design study. POEMMA will combine the well-developed Orbiting Wide-field Light-collectors (OWL) concept with

Air shower measurements with the LOPES radio antenna array

NASA Astrophysics Data System (ADS)

Lopes Collaboration; Haungs, A.; Apel, W. D.; Arteaga, J. C.; Asch, T.; Auffenberg, J.; Badea, F.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Brüggemann, M.; Buchholz, P.; Buitink, S.; Cantoni, E.; Chiavassa, A.; Cossavella, F.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Engel, R.; Falcke, H.; Finger, M.; Fuhrmann, D.; Gemmeke, H.; Ghia, P. L.; Glasstetter, R.; Grupen, C.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Kickelbick, D.; Kolotaev, Y.; Krömer, O.; Kuijpers, J.; Lafebre, S.; Łuczak, P.; Mathes, H. J.; Mayer, H. J.; Milke, J.; Mitrica, B.; Morello, C.; Navarra, G.; Nehls, S.; Nigl, A.; Oehlschläger, J.; Over, S.; Petcu, M.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Schröder, F.; Sima, O.; Singh, K.; Stümpert, M.; Toma, G.; Trinchero, G. C.; Ulrich, H.; Walkowiak, W.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.; LOPES Collaboration

2009-06-01

LOPES is set up at the location of the KASCADE-Grande extensive air shower experiment in Karlsruhe, Germany and aims to measure and investigate radio pulses from extensive air showers. Since radio waves suffer very little attenuation, radio measurements allow the detection of very distant or highly inclined showers. These waves can be recorded day and night, and provide a bolometric measure of the leptonic shower component. LOPES is designed as a digital radio interferometer using high bandwidths and fast data processing and profits from the reconstructed air shower observables of KASCADE-Grande. The LOPES antennas are absolutely amplitude calibrated allowing to reconstruct the electric field strength which can be compared with predictions from detailed Monte-Carlo simulations. We report about the analysis of correlations present in the radio signals measured by the LOPES 30 antenna array. Additionally, LOPES operates antennas of a different type (LOPESSTAR) which are optimized for an application at the Pierre Auger Observatory. Status, recent results of the data analysis and further perspectives of LOPES and the possible large scale application of this new detection technique are discussed.

IceCube's Search for Neutrinos from Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2016-07-01

In a cubic kilometer of volume of ice under Antarctica, an observatory called IceCube is taking measurements that may help us to determine what causes the ultra-high-energy cosmic rays (UHECRs) we occasionally observe from Earth. A recent study reports on its latest results.Atomic BaseballsCosmic rays are high-energy radiation primarily composed of protons and atomic nuclei. When these charged and extremely energetic particles impact the Earths atmosphere on their journey through space, they generate showers of secondary particles that we then detect.A UHECR is any cosmic-ray particle with a kinetic energy exceeding 1018 eV and some have been detected with energies of more than 1020 eV! In practical terms, this is an atomic nucleus with the same kinetic energy as a baseball pitched at 60mph. These unbelievably energetic particlesare quite rare, but weve observed them for decades. Yet in spite of this, the source of UHECRs is unknown.Illustration of a gamma-ray burst in a star-forming region. Could these phenomena accelerate UHECRs to their enormous energies? [NASA/Swift/Mary Pat Hrybyk-Keith and John Jones]Gamma-Ray Burst FireballsOne proposed source that could accelerate particles to these energies is a gamma-ray burst (GRB). In some models for GRBs, the explosion is envisioned as a relativistically expanding fireball of electrons, photons and protons. Internal shock fronts accelerate electrons and protons within the fireball, generating UHECRs, gamma rays, and neutrinos in the process.Because the charged cosmic-ray particles can be easily deflected as they travel, its difficult to identify where they came from. Neutrinos and photons, on the other hand, both travel largely undeflected through the universe. As a result, if we detect high-energy neutrinos that are correlated with gamma-ray photons from a GRB, this would providestrong support for GRBfireball models for UHECR production.Heading Under the IceThe IceCube Laboratory in Antarctica. Beneath the Antarctic

Sub-luminal pulses from cosmic ray air showers

NASA Technical Reports Server (NTRS)

Linsley, J.

1985-01-01

Some of the signals produced by air showers in scintillators possess a distinctive feature, a sub-luminal pulse (SLP) following the normal one with a time delay of approximately 1.5 r/c. The average amplitude of the SLP corresponds to an energy deposit of about 50 MeV, three times as much as is deposited in a typical scintillator by vertical minimum ionizing muons. The SLP account for approximately 5% of the energy deposited in the atmosphere by IR showers with energy 10 to the 10th power GeV at impact parameters 1 km. Assuming that these pulses are due to neutrons travelling with a speed slightly less than c, they provide a unique means of estimating E sub h, the energy deposited by slow hadrons, in showers of this very high energy. On the other hand, if not allowed for properly, these pulses are liable to cause errors in estimating the impact parameters of large showers from pulse width observations.

Neutrino Physics at Drexel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, Charles; Dolinski, Michelle; Neilson, Russell

Our primary goal is to improve the understanding of the properties and interactions of neutrinos. We are pursuing this by means of the DUNE long-baseline and PROSPECT short-baseline neutrino experiments. For DUNE, a neutrino beam from Fermilab will be detected at the SURF facility in South Dakota, with the aim of determining the neutrino mass hierarchy (the mass ordering of neutrino flavors), and a measurement or limit on CP-violation via neutrinos. Our near-term experimental goal is to improve the characterization of the neutrino beam by measurements of muons produced as a byproduct of neutrino beam generation, to quantify the beammore » composition and flux. The short-range neutrino program has the aim of using the HFIR reactor at Oak Ridge as a neutrino source, with a detector placed nearby to find if there are short-distance oscillations to sterile neutrino flavors, and to resolve the 'reactor neutrino spectral anomaly' which has shown up as an unexplained 'bump' in the neutrino energy spectrum in recent experiments.« less

Exogenous and Endogenous Determinants of Blood Trihalomethane Levels after Showering

PubMed Central

Backer, Lorraine C.; Lan, Qing; Blount, Benjamin C.; Nuckols, J.R.; Branch, Robert; Lyu, Christopher W.; Kieszak, Stephanie M.; Brinkman, Marielle C.; Gordon, Sydney M.; Flanders, W. Dana; Romkes, Marjorie; Cantor, Kenneth P.

2008-01-01

Background We previously conducted a study to assess whether household exposures to tap water increased an individual’s internal dose of trihalomethanes (THMs). Increases in blood THM levels among subjects who showered or bathed were variable, with increased levels tending to cluster in two groups. Objectives Our goal was to assess the importance of personal characteristics, previous exposures, genetic polymorphisms, and environmental exposures in determining THM concentrations in blood after showering. Methods One hundred study participants completed a health symptom questionnaire, a 48-hr food and water consumption diary, and took a 10-min shower in a controlled setting. We examined THM levels in blood samples collected at baseline and 10 and 30 min after the shower. We assessed the significance of personal characteristics, previous exposures to THMs, and specific gene polymorphisms in predicting postshower blood THM concentrations. Results We did not observe the clustering of blood THM concentrations observed in our earlier study. We found that environmental THM concentrations were important predictors of blood THM concentrations immediately after showering. For example, the chloroform concentration in the shower stall air was the most important predictor of blood chloroform levels 10 min after the shower (p < 0.001). Personal characteristics, previous exposures to THMs, and specific polymorphisms in CYP2D6 and GSTT1 genes were significant predictors of both baseline and postshowering blood THM concentrations as well as of changes in THM concentrations associated with showering. Conclusion The inclusion of information about individual physiologic characteristics and environmental measurements would be valuable in future studies to assess human health effects from exposures to THMs in tap water. PMID:18197300

Lethal carbon monoxide toxicity in a concrete shower unit.

PubMed

Heath, Karen; Byard, Roger W

2018-05-23

A 47-year-old previously-well woman was found dead on the floor of a shower cubicle on a property in rural South Australia. The impression of the attending doctor and police was of collapse due to natural disease. Although there was significant stenosing coronary artery atherosclerosis found at autopsy, cherry pink discoloration of tissues prompted measurement of the blood carboxyhemoglobin level which was found to be 55%. The source of the gas was a poorly-maintained hot water heater that was mounted on the inside wall of the shower. Construction of the shower using an impermeable concrete rain water tank had caused gas accumulation when the water heater malfunctioned. Had lethal carbon monoxide exposure not been identified others using the same shower unit would also have been at risk.

Spatial distribution of Cherenkov light from cascade showers in water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khomyakov, V. A., E-mail: VAKhomyakov@mephi.ru; Bogdanov, A. G.; Kindin, V. V.

2016-12-15

The spatial distribution of the Cherenkov light generated by cascade showers is analyzed using the NEVOD Cherenkov water detector. The dependence of the Cherenkov light intensity on the depth of shower development at various distances from the shower axis is investigated for the first time. The experimental data are compared with the Cherenkov light distributions predicted by various models for the scattering of cascade particles.

RNA stores tau reversibly in complex coacervates

PubMed Central

Lin, Yanxian; Eschmann, Neil A.; Zhou, Hongjun; Rauch, Jennifer N.; Hernandez, Israel; Guzman, Elmer; Kosik, Kenneth S.; Han, Songi

2017-01-01

Nonmembrane-bound organelles that behave like liquid droplets are widespread among eukaryotic cells. Their dysregulation appears to be a critical step in several neurodegenerative conditions. Here, we report that tau protein, the primary constituent of Alzheimer neurofibrillary tangles, can form liquid droplets and therefore has the necessary biophysical properties to undergo liquid-liquid phase separation (LLPS) in cells. Consonant with the factors that induce LLPS, tau is an intrinsically disordered protein that complexes with RNA to form droplets. Uniquely, the pool of RNAs to which tau binds in living cells are tRNAs. This phase state of tau is held in an approximately 1:1 charge balance across the protein and the nucleic acid constituents, and can thus be maximal at different RNA:tau mass ratios, depending on the biopolymer constituents involved. This feature is characteristic of complex coacervation. We furthermore show that the LLPS process is directly and sensitively tuned by salt concentration and temperature, implying it is modulated by both electrostatic interactions between the involved protein and nucleic acid constituents, as well as net changes in entropy. Despite the high protein concentration within the complex coacervate phase, tau is locally freely tumbling and capable of diffusing through the droplet interior. In fact, tau in the condensed phase state does not reveal any immediate changes in local protein packing, local conformations and local protein dynamics from that of tau in the dilute solution state. In contrast, the population of aggregation-prone tau as induced by the complexation with heparin is accompanied by large changes in local tau conformations and irreversible aggregation. However, prolonged residency within the droplet state eventually results in the emergence of detectable β-sheet structures according to thioflavin-T assay. These findings suggest that the droplet state can incubate tau and predispose the protein toward the

Solar atmospheric neutrinos: A new neutrino floor for dark matter searches

NASA Astrophysics Data System (ADS)

Ng, Kenny C. Y.; Beacom, John F.; Peter, Annika H. G.; Rott, Carsten

2017-11-01

As is well known, dark matter direct detection experiments will ultimately be limited by a "neutrino floor," due to the scattering of nuclei by MeV neutrinos from, e.g., nuclear fusion in the Sun. Here we point out the existence of a new neutrino floor that will similarly limit indirect detection with the Sun, due to high-energy neutrinos from cosmic-ray interactions with the solar atmosphere. We have two key findings. First, solar atmospheric neutrinos ≲1 TeV cause a sensitivity floor for standard weakly interacting massive particles (WIMP) scenarios, for which higher-energy neutrinos are absorbed in the Sun. This floor will be reached once the present sensitivity is improved by just 1 order of magnitude. Second, for neutrinos ≳1 TeV , which can be isolated by muon energy loss rate, solar atmospheric neutrinos should soon be detectable in IceCube. Discovery will help probe the complicated effects of solar magnetic fields on cosmic rays. These events will be backgrounds to WIMP scenarios with long-lived mediators, for which higher-energy neutrinos can escape from the Sun.

Geometric phase of neutrinos: Differences between Dirac and Majorana neutrinos

NASA Astrophysics Data System (ADS)

Capolupo, A.; Giampaolo, S. M.; Hiesmayr, B. C.; Vitiello, G.

2018-05-01

We analyze the non-cyclic geometric phase for neutrinos. We find that the geometric phase and the total phase associated to the mixing phenomenon provide a theoretical tool to distinguish between Dirac and Majorana neutrinos. Our results hold for neutrinos propagating in vacuum and through the matter. We feed the values of the experimental parameters in our formulas in order to make contact with experiments. Although it remains an open question how the geometric phase of neutrinos could be detected, our theoretical results may open new scenarios in the investigation of the neutrino nature.

Solar Neutrinos

DOE R&D Accomplishments Database

Davis, R. Jr.; Harmer, D. S.

1964-12-01

The prospect of studying the solar energy generation process directly by observing the solar neutrino radiation has been discussed for many years. The main difficulty with this approach is that the sun emits predominantly low energy neutrinos, and detectors for observing low fluxes of low energy neutrinos have not been developed. However, experimental techniques have been developed for observing neutrinos, and one can foresee that in the near future these techniques will be improved sufficiently in sensitivity to observe solar neutrinos. At the present several experiments are being designed and hopefully will be operating in the next year or so. We will discuss an experiment based upon a neutrino capture reaction that is the inverse of the electron-capture radioactive decay of argon-37. The method depends upon exposing a large volume of a chlorine compound, removing the radioactive argon-37 and observing the characteristic decay in a small low-level counter.

Oscillation properties of active and sterile neutrinos and neutrino anomalies at short distances

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khruschov, V. V., E-mail: khruschov-vv@nrcki.ru; Fomichev, S. V., E-mail: fomichev-sv@nrcki.ru; Titov, O. A., E-mail: titov-oa@nrcki.ru

2016-09-15

A generalized phenomenological (3 + 2 + 1) model featuring three active and three sterile neutrinos that is intended for calculating oscillation properties of neutrinos for the case of a normal active neutrino mass hierarchy and a large splitting between the mass of one sterile neutrino and the masses of the other two sterile neutrinos is considered. A new parametrization and a specific form of the general mixing matrix are proposed for active and sterile neutrinos with allowance for possible CP violation in the lepton sector, and test values are chosen for the neutrino masses and mixing parameters. The probabilitiesmore » for the transitions between different neutrino flavors are calculated, and graphs representing the probabilities for the disappearance of muon neutrinos/antineutrinos and the appearance of electron neutrinos/antineutrinos in a beam of muon neutrinos/antineutrinos versus the distance from the neutrino source for various values of admissible model parameters at neutrino energies not higher than 50 MeV, as well as versus the ratio of this distance to the neutrino energy, are plotted. It is shown that the short-distance accelerator anomaly in neutrino data (LNSD anomaly) can be explained in the case of a specific mixing matrix for active and sterile neutrinos (which belongs to the a{sub 2} type) at the chosen parameter values. The same applies to the short-distance reactor and gallium anomalies. The theoretical results obtained in the present study can be used to interpret and predict the results of ground-based neutrino experiments aimed at searches for sterile neutrinos, as well as to analyze some astrophysical observational data.« less

Oscillation properties of active and sterile neutrinos and neutrino anomalies at short distances

NASA Astrophysics Data System (ADS)

Khruschov, V. V.; Fomichev, S. V.; Titov, O. A.

2016-09-01

A generalized phenomenological (3 + 2 + 1) model featuring three active and three sterile neutrinos that is intended for calculating oscillation properties of neutrinos for the case of a normal activeneutrino mass hierarchy and a large splitting between the mass of one sterile neutrino and the masses of the other two sterile neutrinos is considered. A new parametrization and a specific form of the general mixing matrix are proposed for active and sterile neutrinos with allowance for possible CP violation in the lepton sector, and test values are chosen for the neutrino masses and mixing parameters. The probabilities for the transitions between different neutrino flavors are calculated, and graphs representing the probabilities for the disappearance of muon neutrinos/antineutrinos and the appearance of electron neutrinos/antineutrinos in a beam of muon neutrinos/antineutrinos versus the distance from the neutrino source for various values of admissible model parameters at neutrino energies not higher than 50 MeV, as well as versus the ratio of this distance to the neutrino energy, are plotted. It is shown that the short-distance accelerator anomaly in neutrino data (LNSD anomaly) can be explained in the case of a specific mixing matrix for active and sterile neutrinos (which belongs to the a 2 type) at the chosen parameter values. The same applies to the short-distance reactor and gallium anomalies. The theoretical results obtained in the present study can be used to interpret and predict the results of ground-based neutrino experiments aimed at searches for sterile neutrinos, as well as to analyze some astrophysical observational data.

The Intermediate Neutrino Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, C.; Alonso, J. R.; Ankowski, A. M.

2017-04-03

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topicsmore » on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop.« less

Probing the radio emission from air showers with polarization measurements

NASA Astrophysics Data System (ADS)

Aab, A.; Abreu, P.; Aglietta, M.; Ahlers, M.; Ahn, E. J.; Albuquerque, I. F. M.; Allekotte, I.; Allen, J.; Allison, P.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Alves Batista, R.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Antičić, T.; Aramo, C.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Badescu, A. M.; Barber, K. B.; Bardenet, R.; Bäuml, J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; BenZvi, S.; Berat, C.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brancus, I.; Brogueira, P.; Brown, W. C.; Buchholz, P.; Bueno, A.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, B.; Caccianiga, L.; Candusso, M.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Cheng, S. H.; Chiavassa, A.; Chinellato, J. A.; Chudoba, J.; Cilmo, M.; Clay, R. W.; Cocciolo, G.; Colalillo, R.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Coutu, S.; Covault, C. E.; Criss, A.; Cronin, J.; Curutiu, A.; Dallier, R.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; De Domenico, M.; de Jong, S. J.; De La Vega, G.; de Mello Junior, W. J. M.; de Mello Neto, J. R. T.; De Mitri, I.; de Souza, V.; de Vries, K. D.; del Peral, L.; Deligny, O.; Dembinski, H.; Dhital, N.; Di Giulio, C.; Di Matteo, A.; Diaz, J. C.; Díaz Castro, M. L.; Diep, P. N.; Diogo, F.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; dos Anjos, J. C.; Dova, M. T.; Ebr, J.; Engel, R.; Erdmann, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Facal San Luis, P.; Falcke, H.; Fang, K.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Fick, B.; Figueira, J. M.; Filevich, A.; Filipčič, A.; Foerster, N.; Fox, B. D.; Fracchiolla, C. E.; Fraenkel, E. D.; Fratu, O.; Fröhlich, U.; Fuchs, B.; Gaior, R.; Gamarra, R. F.; Gambetta, S.; García, B.; Garcia Roca, S. T.; Garcia-Gamez, D.; Garcia-Pinto, D.; Garilli, G.; Gascon Bravo, A.; Gemmeke, H.; Ghia, P. L.; Giammarchi, M.; Giller, M.; Gitto, J.; Glaser, C.; Glass, H.; Gomez Albarracin, F.; Gómez Berisso, M.; Gómez Vitale, P. F.; Gonçalves, P.; Gonzalez, J. G.; Gookin, B.; Gorgi, A.; Gorham, P.; Gouffon, P.; Grebe, S.; Griffith, N.; Grillo, A. F.; Grubb, T. D.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hansen, P.; Harari, D.; Harrison, T. A.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Hollon, N.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huber, D.; Huege, T.; Insolia, A.; Isar, P. G.; Jansen, S.; Jarne, C.; Josebachuili, M.; Kadija, K.; Kambeitz, O.; Kampert, K. H.; Karhan, P.; Kasper, P.; Katkov, I.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Knapp, J.; Krause, R.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuempel, D.; Kunka, N.; La Rosa, G.; LaHurd, D.; Latronico, L.; Lauer, R.; Lauscher, M.; Lautridou, P.; Le Coz, S.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Lopez Agüera, A.; Louedec, K.; Lozano Bahilo, J.; Lu, L.; Lucero, A.; Ludwig, M.; Lyberis, H.; Maccarone, M. C.; Malacari, M.; Maldera, S.; Maller, J.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Mariş, I. C.; Marquez Falcon, H. R.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Martínez Bravo, O.; Martraire, D.; Masías Meza, J. J.; Mathes, H. J.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurel, D.; Maurizio, D.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Messina, S.; Meyhandan, R.; Mićanović, S.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Molina-Bueno, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morales, B.; Morello, C.; Moreno, J. C.; Mostafá, M.; Moura, C. A.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Neuser, J.; Nhung, P. T.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Nožka, L.; Oehlschläger, J.; Olinto, A.; Oliveira, M.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Parente, G.; Parra, A.; Pastor, S.; Paul, T.; Pech, M.; PeÂķala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Petrera, S.; Petrolini, A.; Petrov, Y.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Pontz, M.; Porcelli, A.; Preda, T.; Privitera, P.; Prouza, M.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rivera, H.; Rizi, V.; Roberts, J.; Rodrigues de Carvalho, W.; Rodriguez Cabo, I.; Rodriguez Fernandez, G.; Rodriguez Martino, J.; Rodriguez Rojo, J.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Rouillé-d'Orfeuil, B.; Roulet, E.; Rovero, A. C.; Rühle, C.; Saffi, S. J.; Saftoiu, A.; Salamida, F.; Salazar, H.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Sanchez-Lucas, P.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarmento, R.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Scholten, O.; Schoorlemmer, H.; Schovánek, P.; Schröder, F. G.; Schulz, A.; Schulz, J.; Sciutto, S. J.; Scuderi, M.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Spinka, H.; Squartini, R.; Srivastava, Y. N.; Stanič, S.; Stapleton, J.; Stasielak, J.; Stephan, M.; Straub, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Šuša, T.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Tapia, A.; Tartare, M.; Taşcǎu, O.; Thao, N. T.; Tiffenberg, J.; Timmermans, C.; Tkaczyk, W.; Todero Peixoto, C. J.; Toma, G.; Tomankova, L.; Tomé, B.; Tonachini, A.; Torralba Elipe, G.; Torres Machado, D.; Travnicek, P.; Tridapalli, D. B.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van den Berg, A. M.; van Velzen, S.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Wahlberg, H.; Wahrlich, P.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Werner, F.; Westerhoff, S.; Whelan, B. J.; Widom, A.; Wieczorek, G.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Wundheiler, B.; Wykes, S.; Yamamoto, T.; Yapici, T.; Younk, P.; Yuan, G.; Yushkov, A.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Zhou, J.; Zhu, Y.; Zimbres Silva, M.; Ziolkowski, M.; Pierre Auger Collaboration

2014-03-01

The emission of radio waves from air showers has been attributed to the so-called geomagnetic emission process. At frequencies around 50 MHz this process leads to coherent radiation which can be observed with rather simple setups. The direction of the electric field induced by this emission process depends only on the local magnetic field vector and on the incoming direction of the air shower. We report on measurements of the electric field vector where, in addition to this geomagnetic component, another component has been observed that cannot be described by the geomagnetic emission process. The data provide strong evidence that the other electric field component is polarized radially with respect to the shower axis, in agreement with predictions made by Askaryan who described radio emission from particle showers due to a negative charge excess in the front of the shower. Our results are compared to calculations which include the radiation mechanism induced by this charge-excess process.

Penetrative nature of high energy showers observed in Chacaltaya emulsion chamber

NASA Technical Reports Server (NTRS)

Funayama, Y.; Tamada, M.

1985-01-01

About 30% of single core showers with E (sup gamma) 10 TeV have stronger penetrating power than that expected from electromagnetic showers (e,gamma). On the other hand, their starting points of cascades in the chamber are found to be as shallow as those of (e,gamma) components. It is suggested that those showers are very collimated bundles of hadron and (e,gamma) component. Otherwise, it is assumed that the collision mean free path of those showers in the chamber is shorter than that of hadron with geometrical value.

Toroidal magnetized iron neutrino detector for a neutrino factory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bross, A.; Wands, R.; Bayes, R.

2013-08-01

A neutrino factory has unparalleled physics reach for the discovery and measurement of CP violation in the neutrino sector. A far detector for a neutrino factory must have good charge identification with excellent background rejection and a large mass. An elegant solution is to construct a magnetized iron neutrino detector (MIND) along the lines of MINOS, where iron plates provide a toroidal magnetic field and scintillator planes provide 3D space points. In this report, the current status of a simulation of a toroidal MIND for a neutrino factory is discussed in light of the recent measurements of largemore » $$\\theta_{13}$$. The response and performance using the 10 GeV neutrino factory configuration are presented. It is shown that this setup has equivalent $$\\delta_{CP}$$ reach to a MIND with a dipole field and is sensitive to the discovery of CP violation over 85% of the values of $$\\delta_{CP}$$.« less

Measurement of the Neutrino Mixing Angle θ23 in NOvA

NASA Astrophysics Data System (ADS)

Adamson, P.; Aliaga, L.; Ambrose, D.; Anfimov, N.; Antoshkin, A.; Arrieta-Diaz, E.; Augsten, K.; Aurisano, A.; Backhouse, C.; Baird, M.; Bambah, B. A.; Bays, K.; Behera, B.; Bending, S.; Bernstein, R.; Bhatnagar, V.; Bhuyan, B.; Bian, J.; Blackburn, T.; Bolshakova, A.; Bromberg, C.; Brown, J.; Brunetti, G.; Buchanan, N.; Butkevich, A.; Bychkov, V.; Campbell, M.; Catano-Mur, E.; Childress, S.; Choudhary, B. C.; Chowdhury, B.; Coan, T. E.; Coelho, J. A. B.; Colo, M.; Cooper, J.; Corwin, L.; Cremonesi, L.; Cronin-Hennessy, D.; Davies, G. S.; Davies, J. P.; Derwent, P. F.; Desai, S.; Dharmapalan, R.; Ding, P.; Djurcic, Z.; Dukes, E. C.; Duyang, H.; Edayath, S.; Ehrlich, R.; Feldman, G. J.; Frank, M. J.; Gabrielyan, M.; Gallagher, H. R.; Germani, S.; Ghosh, T.; Giri, A.; Gomes, R. A.; Goodman, M. C.; Grichine, V.; Group, R.; Grover, D.; Guo, B.; Habig, A.; Hartnell, J.; Hatcher, R.; Hatzikoutelis, A.; Heller, K.; Himmel, A.; Holin, A.; Hylen, J.; Jediny, F.; Judah, M.; Kafka, G. K.; Kalra, D.; Kasahara, S. M. S.; Kasetti, S.; Keloth, R.; Kolupaeva, L.; Kotelnikov, S.; Kourbanis, I.; Kreymer, A.; Kumar, A.; Kurbanov, S.; Lang, K.; Lee, W. M.; Lin, S.; Liu, J.; Lokajicek, M.; Lozier, J.; Luchuk, S.; Maan, K.; Magill, S.; Mann, W. A.; Marshak, M. L.; Matera, K.; Matveev, V.; Méndez, D. P.; Messier, M. D.; Meyer, H.; Miao, T.; Miller, W. H.; Mishra, S. R.; Mohanta, R.; Moren, A.; Mualem, L.; Muether, M.; Mufson, S.; Murphy, R.; Musser, J.; Nelson, J. K.; Nichol, R.; Niner, E.; Norman, A.; Nosek, T.; Oksuzian, Y.; Olshevskiy, A.; Olson, T.; Paley, J.; Pandey, P.; Patterson, R. B.; Pawloski, G.; Pershey, D.; Petrova, O.; Petti, R.; Phan-Budd, S.; Plunkett, R. K.; Poling, R.; Potukuchi, B.; Principato, C.; Psihas, F.; Radovic, A.; Rameika, R. A.; Rebel, B.; Reed, B.; Rocco, D.; Rojas, P.; Ryabov, V.; Sachdev, K.; Sail, P.; Samoylov, O.; Sanchez, M. C.; Schroeter, R.; Sepulveda-Quiroz, J.; Shanahan, P.; Sheshukov, A.; Singh, J.; Singh, J.; Singh, P.; Singh, V.; Smolik, J.; Solomey, N.; Song, E.; Sousa, A.; Soustruznik, K.; Strait, M.; Suter, L.; Talaga, R. L.; Tamsett, M. C.; Tas, P.; Thayyullathil, R. B.; Thomas, J.; Tian, X.; Tognini, S. C.; Tripathi, J.; Tsaris, A.; Urheim, J.; Vahle, P.; Vasel, J.; Vinton, L.; Vold, A.; Vrba, T.; Wang, B.; Wetstein, M.; Whittington, D.; Wojcicki, S. G.; Wolcott, J.; Yadav, N.; Yang, S.; Zalesak, J.; Zamorano, B.; Zwaska, R.; NOvA Collaboration

2017-04-01

This Letter reports new results on muon neutrino disappearance from NOvA, using a 14 kton detector equivalent exposure of 6.05 ×1 020 protons on target from the NuMI beam at the Fermi National Accelerator Laboratory. The measurement probes the muon-tau symmetry hypothesis that requires maximal θ23 mixing (θ23=π /4 ). Assuming the normal mass hierarchy, we find Δ m322 =(2.67 ±0.11 )×10-3 eV2 and sin2θ23 at the two statistically degenerate values 0.40 4-0.022+0.030 and 0.62 4-0.030+0.022, both at the 68% confidence level. Our data disfavor the maximal mixing scenario with 2.6 σ significance.

Measurement of the neutrino mixing angle θ 23 in NOvA

DOE PAGES

Adamson, P.; Aliaga, L.; Ambrose, D.; ...

2017-04-10

This Letter reports new results on muon neutrino disappearance from NOvA, using a 14 kton detector equivalent exposure ofmore » $$6.05\\times10^{20}$$ protons-on-target from the NuMI beam at the Fermi National Accelerator Laboratory. The measurement probes the muon-tau symmetry hypothesis that requires maximal mixing ($$\\theta_{23} = \\pi/4$$). Assuming the normal mass hierarchy, we find $$\\Delta m^2 = (2.67 \\pm 0.11)\\times 10^{-3}$$ eV$^2$ and $$\\sin^2 \\theta_{23}$$ at the two statistically degenerate values $$0.404^{+0.030}_{-0.022}$$ and $$0.624^{+0.022}_{-0.030}$$, both at the 68% confidence level. Finally, our data disfavor the maximal mixing scenario with 2.6 $$\\sigma$$ significance.« less

Insulin dysfunction and Tau pathology.

PubMed

El Khoury, Noura B; Gratuze, Maud; Papon, Marie-Amélie; Bretteville, Alexis; Planel, Emmanuel

2014-01-01

The neuropathological hallmarks of Alzheimer's disease (AD) include senile plaques of β-amyloid (Aβ) peptides (a cleavage product of the Amyloid Precursor Protein, or APP) and neurofibrillary tangles (NFT) of hyperphosphorylated Tau protein assembled in paired helical filaments (PHF). NFT pathology is important since it correlates with the degree of cognitive impairment in AD. Only a small proportion of AD is due to genetic variants, whereas the large majority of cases (~99%) is late onset and sporadic in origin. The cause of sporadic AD is likely to be multifactorial, with external factors interacting with biological or genetic susceptibilities to accelerate the manifestation of the disease. Insulin dysfunction, manifested by diabetes mellitus (DM) might be such factor, as there is extensive data from epidemiological studies suggesting that DM is associated with an increased relative risk for AD. Type 1 diabetes (T1DM) and type 2 diabetes (T2DM) are known to affect multiple cognitive functions in patients. In this context, understanding the effects of diabetes on Tau pathogenesis is important since Tau pathology show a strong relationship to dementia in AD, and to memory loss in normal aging and mild cognitive impairment. Here, we reviewed preclinical studies that link insulin dysfunction to Tau protein pathogenesis, one of the major pathological hallmarks of AD. We found more than 30 studies reporting Tau phosphorylation in a mouse or rat model of insulin dysfunction. We also payed attention to potential sources of artifacts, such as hypothermia and anesthesia, that were demonstrated to results in Tau hyperphosphorylation and could major confounding experimental factors. We found that very few studies reported the temperature of the animals, and only a handful did not use anesthesia. Overall, most published studies showed that insulin dysfunction can promote Tau hyperphosphorylation and pathology, both directly and indirectly, through hypothermia.

Insulin dysfunction and Tau pathology

PubMed Central

El Khoury, Noura B.; Gratuze, Maud; Papon, Marie-Amélie; Bretteville, Alexis; Planel, Emmanuel

2013-01-01

The neuropathological hallmarks of Alzheimer's disease (AD) include senile plaques of β-amyloid (Aβ) peptides (a cleavage product of the Amyloid Precursor Protein, or APP) and neurofibrillary tangles (NFT) of hyperphosphorylated Tau protein assembled in paired helical filaments (PHF). NFT pathology is important since it correlates with the degree of cognitive impairment in AD. Only a small proportion of AD is due to genetic variants, whereas the large majority of cases (~99%) is late onset and sporadic in origin. The cause of sporadic AD is likely to be multifactorial, with external factors interacting with biological or genetic susceptibilities to accelerate the manifestation of the disease. Insulin dysfunction, manifested by diabetes mellitus (DM) might be such factor, as there is extensive data from epidemiological studies suggesting that DM is associated with an increased relative risk for AD. Type 1 diabetes (T1DM) and type 2 diabetes (T2DM) are known to affect multiple cognitive functions in patients. In this context, understanding the effects of diabetes on Tau pathogenesis is important since Tau pathology show a strong relationship to dementia in AD, and to memory loss in normal aging and mild cognitive impairment. Here, we reviewed preclinical studies that link insulin dysfunction to Tau protein pathogenesis, one of the major pathological hallmarks of AD. We found more than 30 studies reporting Tau phosphorylation in a mouse or rat model of insulin dysfunction. We also payed attention to potential sources of artifacts, such as hypothermia and anesthesia, that were demonstrated to results in Tau hyperphosphorylation and could major confounding experimental factors. We found that very few studies reported the temperature of the animals, and only a handful did not use anesthesia. Overall, most published studies showed that insulin dysfunction can promote Tau hyperphosphorylation and pathology, both directly and indirectly, through hypothermia. PMID:24574966

Some dipole shower studies

NASA Astrophysics Data System (ADS)

Cabouat, Baptiste; Sjöstrand, Torbjörn

2018-03-01

Parton showers have become a standard component in the description of high-energy collisions. Nowadays most final-state ones are of the dipole character, wherein a pair of partons branches into three, with energy and momentum preserved inside this subsystem. For initial-state showers a dipole picture is also possible and commonly used, but the older global-recoil strategy remains a valid alternative, wherein larger groups of partons share the energy-momentum preservation task. In this article we introduce and implement a dipole picture also for initial-state radiation in Pythia, and compare with the existing global-recoil one, and with data. For the case of Deeply Inelastic Scattering we can directly compare with matrix element expressions and show that the dipole picture gives a very good description over the whole phase space, at least for the first branching.

A search for ultrahigh-energy neutrinos and measurement of cosmic ray radio emission with the Antarctic Impulsive Transient Antenna

NASA Astrophysics Data System (ADS)

Hoover, Stephen Lam Douglas

2010-11-01

New astronomical messengers may reveal unexpected aspects of the Universe and have often provided a unique source of fresh physical insights. Neutrinos are a promising new messenger particle, capable of carrying information from otherwise inaccessible sources. The ANtarctic Impulsive Transient Antenna (ANITA) seeks to make the first detection of an ultrahigh-energy (E > 1018 eV) neutrino flux. Such a neutrino flux almost certainly exists, produced in interactions of ultrahigh-energy cosmic rays with photons from the cosmic microwave background. ANITA is a balloon payload which monitors large volumes of the Antarctic ice sheet from an altitude of 38 km. An ultrahigh-energy neutrino which interacts in the ice sheet will produce a particle shower which will coherently radiate Cherenkov radiation in radio wavelengths (<3 GHz). Antennas on the balloon payload can then detect the resulting impulsive radio signal. The full ANITA flew for the first time from 15 December 2006 to 19 January 2007. In this dissertation, I will describe the ground calibration system used to transmit calibration signals to the payload in-flight. I will then describe techniques for analysis of ANITA data and give limits on the ultrahigh-energy neutrino flux implied by the null result of that analysis. Finally, I will demonstrate that ANITA is also sensitive to ultrahigh-energy cosmic rays and show the detection of 16 ultrahigh-energy cosmic-ray events during ANITA's first flight. This constitutes the highest frequency and widest bandwidth radio observations of cosmic-ray emission to date I show the average waveform and spectrum of these events and describe their polarization properties, which are strongly correlated with the geomagnetic field.

No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau).

PubMed

Krut, Jan J; Price, Richard W; Zetterberg, Henrik; Fuchs, Dietmar; Hagberg, Lars; Yilmaz, Aylin; Cinque, Paola; Nilsson, Staffan; Gisslén, Magnus

2017-07-04

The prevalence of neurocognitive deficits are reported to be high in HIV-1 positive patients, even with suppressive antiretroviral treatment, and it has been suggested that HIV can cause accelerated aging of the brain. In this study we measured phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) as a potential marker for premature central nervous system (CNS) aging. P-tau increases with normal aging but is not affected by HIV-associated neurocognitive disorders. With a cross-sectional retrospective design, p-tau, total tau (t-tau), neopterin and HIV-RNA were measured in CSF together with plasma HIV-RNA and blood CD4 + T-cells of 225 HIV-infected patients <50 y of age, subdivided into 3 groups: untreated neuroasymptomatic (NA) (n = 145), on suppressive antiretroviral treatment (cART) (n = 49), and HIV-associated dementia (HAD) (n = 31). HIV-negative healthy subjects served as controls (n = 79). P-tau was not significantly higher in any HIV-infected group compared to HIV-negative controls. Significant increases in t-tau were found as expected in patients with HAD compared to NA, cART, and control groups (p < 0.001 ). P-tau was not higher in HIV-infected patients compared to uninfected controls, thus failing to support a role for premature or accelerated brain aging in HIV infection.

The Extensive Air Shower Experiment Kascade-Grande

NASA Astrophysics Data System (ADS)

Kang, Donghwa; Apel, W. D.; Arteaga, J. C.; Badea, F.; Bekk, K.; Bertaina, M.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Brüggemann, M.; Buchholz, P.; Cantoni, E.; Chiavassa, A.; Cossavella, F.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Engel, R.; Engler, J.; Finger, M.; Fuhrmann, D.; Ghia, P. L.; Gils, H. J.; Glasstetter, R.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kickelbick, D.; Klages, H. O.; Kolotaev, Y.; Łuczak, P.; Mathes, H. J.; Mayer, H. J.; Milke, J.; Mitrica, B.; Morello, C.; Navarra, G.; Nehls, S.; Oehlschläger, J.; Ostapchenko, S.; Over, S.; Petcu, M.; Pierog, T.; Rebel, H.; Roth, M.; Schatz, G.; Schieler, H.; Schröder, F.; Sima, O.; Stümpert, M.; Toma, G.; Trinchero, G. C.; Ulrich, H.; van Buren, J.; Walkowiak, W.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.

The extensive air shower experiment KASCADE-Grande (KArlsruhe Shower Core and Array DEtector and Grande array) is located on site of the Forschungszentrum Karlsruhe in Germany. The original KASCADE experiment consisted of a densely packed scintillator array with unshielded and shielded detectors for the measurement of the electromagnetic and muonic shower component independently, as well as muon tracking devices and a hadron calorimeter. The Grande array as an extension of KASCADE consists of 37 scintillation detector stations covering an area of 700×700 m2. The main goal for the combined measurements of KASCADE and Grande is the investigation of the energy spectrum and composition of primary cosmic rays in the energy range of 1016 to 1018 eV. In this paper an overview of the KASCADE-Grande experiment and recent results will be presented.

Latest results on νμ → ντ oscillations from the OPERA experiment

NASA Astrophysics Data System (ADS)

Komatsu, Masahiro; OPERA Collaboration

2016-04-01

The OPERA experiment is designed to prove neutrino oscillations in the νμ to ντ channel through the direct observation of the tau lepton in tau neutrino charged current interactions. The experiment has accumulated data for five years, from 2008 to 2012, with the CERN Neutrinos to Gran Sasso (CNGS), an almost pure νμ beam. In the last two years, a very large amount of the data accumulated in the nuclear emulsions has been analyzed. The latest results on oscillations with the increased statistics, which include a fourth tau neutrino candidate event, will be presented. Given the extremely low expected background, this result corresponds to the observation of the oscillation process with a four sigma level significance.

Meteor Shower Records: A Reference Table of Observations from Previous Centuries

NASA Astrophysics Data System (ADS)

Koseki, M.

2009-10-01

Meteor history shows the complex nature of meteor showers. The author presents the Comae Berenicids as an example of the difficulties in defining meteor showers for visibility using different observational techniques. It is not useful to give a fixed or coded name to a 'meteor shower' because it may not be real and could lead observers to fictitious results.

cuTauLeaping: A GPU-Powered Tau-Leaping Stochastic Simulator for Massive Parallel Analyses of Biological Systems

PubMed Central

Besozzi, Daniela; Pescini, Dario; Mauri, Giancarlo

2014-01-01

Tau-leaping is a stochastic simulation algorithm that efficiently reconstructs the temporal evolution of biological systems, modeled according to the stochastic formulation of chemical kinetics. The analysis of dynamical properties of these systems in physiological and perturbed conditions usually requires the execution of a large number of simulations, leading to high computational costs. Since each simulation can be executed independently from the others, a massive parallelization of tau-leaping can bring to relevant reductions of the overall running time. The emerging field of General Purpose Graphic Processing Units (GPGPU) provides power-efficient high-performance computing at a relatively low cost. In this work we introduce cuTauLeaping, a stochastic simulator of biological systems that makes use of GPGPU computing to execute multiple parallel tau-leaping simulations, by fully exploiting the Nvidia's Fermi GPU architecture. We show how a considerable computational speedup is achieved on GPU by partitioning the execution of tau-leaping into multiple separated phases, and we describe how to avoid some implementation pitfalls related to the scarcity of memory resources on the GPU streaming multiprocessors. Our results show that cuTauLeaping largely outperforms the CPU-based tau-leaping implementation when the number of parallel simulations increases, with a break-even directly depending on the size of the biological system and on the complexity of its emergent dynamics. In particular, cuTauLeaping is exploited to investigate the probability distribution of bistable states in the Schlögl model, and to carry out a bidimensional parameter sweep analysis to study the oscillatory regimes in the Ras/cAMP/PKA pathway in S. cerevisiae. PMID:24663957

LHC searches for dark sector showers

NASA Astrophysics Data System (ADS)

Cohen, Timothy; Lisanti, Mariangela; Lou, Hou Keong; Mishra-Sharma, Siddharth

2017-11-01

This paper proposes a new search program for dark sector parton showers at the Large Hadron Collider (LHC). These signatures arise in theories characterized by strong dynamics in a hidden sector, such as Hidden Valley models. A dark parton shower can be composed of both invisible dark matter particles as well as dark sector states that decay to Standard Model particles via a portal. The focus here is on the specific case of `semi-visible jets,' jet-like collider objects where the visible states in the shower are Standard Model hadrons. We present a Simplified Model-like parametrization for the LHC observables and propose targeted search strategies for regions of parameter space that are not covered by existing analyses. Following the `mono- X' literature, the portal is modeled using either an effective field theoretic contact operator approach or with one of two ultraviolet completions; sensitivity projections are provided for all three cases. We additionally highlight that the LHC has a unique advantage over direct detection experiments in the search for this class of dark matter theories.

Cometary showers and unseen solar companions

NASA Technical Reports Server (NTRS)

Weissman, P. R.

1984-01-01

The possibility that an invisible solar companion passing through the Oort cloud every 28 Myr precipitates a sufficiently high rate of cometary collisions with the earth to account for periodic mass species extinctions recorded in the fossil record is discussed. A Monte Carlo simulation shows that any hypothesized 'death star' with a 28 Myr orbit would experience an average 10 percent change in period per orbit. Production of an 18-fold increase in cometary impacts would be associated with a 0.055 probability that a 10 km nucleus would hit the earth in a shower once every 510 Myr, longer than the proposed extinction periodicity. However, if the death star orbit has a 0.6 eccentricity and the Oort cloud is sufficiently densely populated, a 2 billion comet shower may be possible. A survey of large terrestrial impact craters indicates that 6-12 craters with diameters over 10 km originated in periodic showers. The extinctions in any case occur at 26 Myr periods and cannot be correlated with the 33 Myr period of recrossing the galactic plane, or with any other known phenomena.

Parton shower and NLO-matching uncertainties in Higgs boson pair production

NASA Astrophysics Data System (ADS)

Jones, Stephen; Kuttimalai, Silvan

2018-02-01

We perform a detailed study of NLO parton shower matching uncertainties in Higgs boson pair production through gluon fusion at the LHC based on a generic and process independent implementation of NLO subtraction and parton shower matching schemes for loop-induced processes in the Sherpa event generator. We take into account the full top-quark mass dependence in the two-loop virtual corrections and compare the results to an effective theory approximation. In the full calculation, our findings suggest large parton shower matching uncertainties that are absent in the effective theory approximation. We observe large uncertainties even in regions of phase space where fixed-order calculations are theoretically well motivated and parton shower effects expected to be small. We compare our results to NLO matched parton shower simulations and analytic resummation results that are available in the literature.

Neutrino Telescopes

NASA Astrophysics Data System (ADS)

de Marzo, C. N.

2002-06-01

Neutrino astronomy is one of the frontier of the high energy astrophysics. I discuss how to build a neutrino telescope and which requirements such a detector must fulfil. A measurable flux of astrophysical neutrinos is predicted by several models for a detector at the cubic kilometer scale. The way pursued until now in building such huge apparatuses is Cherenkov light detection in water or in ice. There have been attempts to build neutrino telescopes and also some projects are yet under construction or under way to start. This situation is reviewed and also techniques alternatives to the Cherenkov light detection are mentioned.

Test results on re-use of reclaimed shower water: Summary. [space stations

NASA Technical Reports Server (NTRS)

Verostko, C. E.; Garcia, R.; Sauer, R.; Linton, A. T.; Elms, T.; Reysa, R. P.

1988-01-01

A microgravity whole body shower (WBS) and waste water recovery systems (WWRS) were evaluated in three separate closed loop tests. Following a protocol similar to that anticipated for the U.S. Space Station, test subjects showered in a prototype whole body shower. The WWRS processes evaluated during the test series were phase change and reverse osmosis (RO). A preprototype Thermoelectric Integrated Hollow Fiber Membrane Evaporation Subsystem phase change process was used for the initial test with chemical pretreatment of the shower water waste input. The second and third tests concentrated on RO technologies. The second test evaluated a dynamic RO membrane consisting of zirconium oxide polyacrylic acid (ZOPA) membranes deposited on the interior diameter of 316L porous stainless steel tubes while the final test employed a thin semipermeable RO membrane deposited on the interior surface of polysulfone hollow fibers. All reclaimed water was post-treated for purity using ion exchange and granular activated carbon beds immediately followed by microbial control treatment using both heat and iodine. The test hardware, controls exercised for whole body showering, types of soaps evaluated, shower subject response to reclaimed water showering, and shower water collection and chemical pretreatment (if required) for microbial control are described. The WWRS recovered water performance and the effectiveness of the reclaimed water post-treatment techniques used for maintaining water purity and microorganism control are compared. Results on chemical and microbial impurity content of the water samples obtained from various locations in the shower water reuse system are summarized.

Long-Baseline Neutrino Experiments

DOE PAGES

Diwan, M. V.; Galymov, V.; Qian, X.; ...

2016-10-19

We review long-baseline neutrino experiments in which neutrinos are detected after traversing macroscopic distances. Over such distances neutrinos have been found to oscillate among flavor states. Experiments with solar, atmospheric, reactor, and accelerator neutrinos have resulted in a coherent picture of neutrino masses and mixing of the three known flavor states. We will summarize the current best knowledge of neutrino parameters and phenomenology with our focus on the evolution of the experimental technique. We will proceed from the rst evidence produced by astrophysical neutrino sources to the current open questions and the goals of future research

Caspase-2 cleavage of tau reversibly impairs memory.

PubMed

Zhao, Xiaohui; Kotilinek, Linda A; Smith, Benjamin; Hlynialuk, Chris; Zahs, Kathleen; Ramsden, Martin; Cleary, James; Ashe, Karen H

2016-11-01

In Alzheimer's disease (AD) and other tauopathies, the tau protein forms fibrils, which are believed to be neurotoxic. However, fibrillar tau has been dissociated from neuron death and network dysfunction, suggesting the involvement of nonfibrillar species. Here we describe a novel pathological process in which caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines. The truncation product, Δtau314, resists fibrillation and is present at higher levels in brains from cognitively impaired mice and humans with AD. The expression of tau mutants that resisted caspase-2 cleavage prevented tau from infiltrating spines, dislocating glutamate receptors and impairing synaptic function in cultured neurons, and it prevented memory deficits and neurodegeneration in mice. Decreasing the levels of caspase-2 restored long-term memory in mice that had existing deficits. Our results suggest an overall treatment strategy for re-establishing synaptic function and restoring memory in patients with AD by preventing tau from accumulating in dendritic spines.

Thickness of the particle swarm in cosmic ray air showers

NASA Technical Reports Server (NTRS)

Linsley, J.

1985-01-01

The average dispersion in arrival time of air shower particles detected with a scintillator at an impact parameter r is described with accuracy 5-10% by the empirical formula sigma = Sigma sub to (1+r/r sub t) sup b, where Sigma sub to = 2.6 ns, r sub t = 30m and b = (1.94 + or - .08) (0.39 + or - .06) sec Theta, for r 2 km, 10 to the 8th power E 10 to the 11th power GeV, and Theta 60 deg. (E is the primary energy and theta is the zenith angle). The amount of fluctuation in sigma sub t due to fluctuations in the level of origin and shower development is less than 20%. These results provide a basis for estimating the impact parameters of very larger showers with data from very small detector arrays (mini-arrays). The energy of such showers can then be estimated from the local particle density. The formula also provides a basis for estimating the angular resolution of air shower array-telescopes.

Sterile neutrinos in cosmology

NASA Astrophysics Data System (ADS)

Abazajian, Kevork N.

2017-11-01

Sterile neutrinos are natural extensions to the standard model of particle physics in neutrino mass generation mechanisms. If they are relatively light, less than approximately 10 keV, they can alter cosmology significantly, from the early Universe to the matter and radiation energy density today. Here, we review the cosmological role such light sterile neutrinos can play from the early Universe, including production of keV-scale sterile neutrinos as dark matter candidates, and dynamics of light eV-scale sterile neutrinos during the weakly-coupled active neutrino era. We review proposed signatures of light sterile neutrinos in cosmic microwave background and large scale structure data. We also discuss keV-scale sterile neutrino dark matter decay signatures in X-ray observations, including recent candidate ∼3.5 keV X-ray line detections consistent with the decay of a ∼7 keV sterile neutrino dark matter particle.

Neutrino phenomenology

DOE PAGES

Coloma, Pilar

2016-11-21

Neutrino oscillations have demonstrated that neutrinos have mass and, by now, oscillation experiments have been able to determine most of the parameters in the leptonic mixing matrix with a very good accuracy. Nevertheless, there are still many open questions in the neutrino sector. As a result, I will briefly discuss some of these questions, pointing out possible experimental avenues to address them.

Radio detection of extensive air showers

NASA Astrophysics Data System (ADS)

Huege, Tim

2017-12-01

Radio detection of extensive air showers initiated in the Earth's atmosphere has made tremendous progress in the last decade. Today, radio detection is routinely used in several cosmic-ray observatories. The physics of the radio emission in air showers is well-understood, and analysis techniques have been developed to determine the arrival direction, the energy and an estimate for the mass of the primary particle from the radio measurements. The achieved resolutions are competitive with those of more traditional techniques. In this article, I shortly review the most important achievements and discuss the potential for future applications.

Solar neutrino spectroscopy

NASA Astrophysics Data System (ADS)

Wurm, Michael

2017-04-01

More than forty years after the first detection of neutrinos from the Sun, the spectroscopy of solar neutrinos has proven to be an on-going success story. The long-standing puzzle about the observed solar neutrino deficit has been resolved by the discovery of neutrino flavor oscillations. Today's experiments have been able to solidify the standard MSW-LMA oscillation scenario by performing precise measurements over the whole energy range of the solar neutrino spectrum. This article reviews the enabling experimental technologies: On the one hand multi-kiloton-scale water Cherenkov detectors performing measurements in the high-energy regime of the spectrum, on the other end ultrapure liquid-scintillator detectors that allow for a low-threshold analysis. The current experimental results on the fluxes, spectra and time variation of the different components of the solar neutrino spectrum will be presented, setting them in the context of both neutrino oscillation physics and the hydrogen fusion processes embedded in the Standard Solar Model. Finally, the physics potential of state-of-the-art detectors and a next generation of experiments based on novel techniques will be assessed in the context of the most interesting open questions in solar neutrino physics: a precise measurement of the vacuum-matter transition curve of electron-neutrino oscillation probability that offers a definitive test of the basic MSW-LMA scenario or the appearance of new physics; and a first detection of neutrinos from the CNO cycle that will provide new information on solar metallicity and stellar physics.

Sterile Neutrinos and Seesaws

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lincoln, Don

Time and again, the study of neutrinos has confounded scientists. One very peculiar property of neutrinos is that only neutrinos with a specific spin configuration have been observed. In this video, Fermilab’s Dr. Don Lincoln talks about this and lays out the possibility that other types of neutrinos might exist, called right handed or sterile neutrinos.

Pseudoscalar—sterile neutrino interactions: reconciling the cosmos with neutrino oscillations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Archidiacono, Maria; Gariazzo, Stefano; Giunti, Carlo

2016-08-01

The Short BaseLine (SBL) neutrino oscillation anomalies hint at the presence of a sterile neutrino with a mass of around 1 eV. However, such a neutrino is incompatible with cosmological data, in particular observations of the Cosmic Microwave Background (CMB) anisotropies. However, this conclusion can change by invoking new physics. One possibility is to introduce a secret interaction in the sterile neutrino sector mediated by a light pseudoscalar. In this pseudoscalar model, CMB data prefer a sterile neutrino mass that is fully compatible with the mass ranges suggested by SBL anomalies. In addition, this model predicts a value of themore » Hubble parameter which is completely consistent with local measurements.« less

Neutrinos from AGN

NASA Technical Reports Server (NTRS)

Kazanas, Demosthenes; White, Nicholas E. (Technical Monitor)

2000-01-01

The great penetrating power of neutrinos makes them ideal probe of astrophysical sites and conditions inaccessible to other forms of radiation. These are the centers of stars (collapsing or not) and the centers of Active Galactic Nuclei (AGN). It has been suggested that AGN presented a very promising source of high energy neutrinos, possibly detectable by underwater neutrino detectors. This paper reviews the evolution of ideas concerning the emission of neutrinos from AGN in view of the more recent developments in gamma-ray astronomy and their implications for the neutrino emission from these class of objects.

Homestake result, sterile neutrinos, and low energy solar neutrino experiments

NASA Astrophysics Data System (ADS)

de Holanda, P. C.; Smirnov, A. Yu.

2004-06-01

The Homestake result is about ˜2σ lower than the Ar-production rate, QAr, predicted by the large mixing angle (LMA) Mikheyev-Smirnov-Wolfenstein solution of the solar neutrino problem. Also there is no apparent upturn of the energy spectrum (R≡Nobs/NSSM) at low energies in SNO and Super-Kamiokande. Both these facts can be explained if a light, Δm201˜(0.2 2)×10-5 eV2, sterile neutrino exists which mixes very weakly with active neutrinos: sin2 2α˜(10-5 10-3). We perform both the analytical and numerical study of the conversion effects in the system of two active neutrinos with the LMA parameters and one weakly mixed sterile neutrino. The presence of sterile neutrino leads to a dip in the survival probability in the intermediate energy range E=(0.5 5) MeV thus suppressing the Be, or/and pep, CNO, as well as B electron neutrino fluxes. Apart from diminishing QAr it leads to decrease of the Ge-production rate and may lead to the decrease of the BOREXINO signal as well as the CC/NC ratio at SNO. Future studies of the solar neutrinos by SNO, SK, BOREXINO, and KamLAND as well as by the new low energy experiments will allow us to check this possibility.

Comparison of big event with calculations of the air shower development

NASA Technical Reports Server (NTRS)

Niwa, M.; Misaki, A.; Matano, T.

1985-01-01

The incidence of high energy hadrons and electron-photons in air showers at various stages of development is calculated. Numerical calculation is used to solve the diffusion equation for a nuclear cascade and analytical calculation for cascade shower induced gamma rays. From these calculations, one can get the longitudinal development of the high energy hadron and electron-photon components, and the energy spectra of these components at various depths of air shower development. The total number of hadrons (N sub H) and electron-photon components (N sub gamma) are related according to stages of the air shower development and primary energy. The relation of the total energy of hadron and electron-photon component above the threshold energy is given. The energy balance between both components is also a useful parameter to study high energy events accompanying air showers. The relation of N sub H and fractional hadronic energy E (sum E sub H sup gamma/sum E sub H sup gamma + Sum E sub gamma) is calculated. This relation is helpful to understand the stage of air shower development(t) and primary energy (E sub p).

Parton shower and NLO-matching uncertainties in Higgs boson pair production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, Stephen; Kuttimalai, Silvan

We perform a detailed study of NLO parton shower matching uncertainties in Higgs boson pair production through gluon fusion at the LHC based on a generic and process independent implementation of NLO subtraction and parton shower matching schemes for loop-induced processes in the Sherpa event generator. We take into account the full top-quark mass dependence in the two-loop virtual corrections and compare the results to an effective theory approximation. In the full calculation, our findings suggest large parton shower matching uncertainties that are absent in the effective theory approximation. Here, we observe large uncertainties even in regions of phase spacemore » where fixed-order calculations are theoretically well motivated and parton shower effects expected to be small. We compare our results to NLO matched parton shower simulations and analytic resummation results that are available in the literature.« less

Parton shower and NLO-matching uncertainties in Higgs boson pair production

DOE PAGES

Jones, Stephen; Kuttimalai, Silvan

2018-02-28

We perform a detailed study of NLO parton shower matching uncertainties in Higgs boson pair production through gluon fusion at the LHC based on a generic and process independent implementation of NLO subtraction and parton shower matching schemes for loop-induced processes in the Sherpa event generator. We take into account the full top-quark mass dependence in the two-loop virtual corrections and compare the results to an effective theory approximation. In the full calculation, our findings suggest large parton shower matching uncertainties that are absent in the effective theory approximation. Here, we observe large uncertainties even in regions of phase spacemore » where fixed-order calculations are theoretically well motivated and parton shower effects expected to be small. We compare our results to NLO matched parton shower simulations and analytic resummation results that are available in the literature.« less

A deep learning-based reconstruction of cosmic ray-induced air showers

NASA Astrophysics Data System (ADS)

Erdmann, M.; Glombitza, J.; Walz, D.

2018-01-01

We describe a method of reconstructing air showers induced by cosmic rays using deep learning techniques. We simulate an observatory consisting of ground-based particle detectors with fixed locations on a regular grid. The detector's responses to traversing shower particles are signal amplitudes as a function of time, which provide information on transverse and longitudinal shower properties. In order to take advantage of convolutional network techniques specialized in local pattern recognition, we convert all information to the image-like grid of the detectors. In this way, multiple features, such as arrival times of the first particles and optimized characterizations of time traces, are processed by the network. The reconstruction quality of the cosmic ray arrival direction turns out to be competitive with an analytic reconstruction algorithm. The reconstructed shower direction, energy and shower depth show the expected improvement in resolution for higher cosmic ray energy.

Air shower detectors in gamma-ray astronomy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sinnis, Gus

2008-01-01

Extensive air shower (EAS) arrays directly detect the particles in an EAS that reach the observation altitude. This detection technique effectively makes air shower arrays synoptic telescopes -- they are capable of simultaneously and continuously viewing the entire overhead sky. Typical air shower detectors have an effective field-of-view of 2 sr and operate nearly 100% of the time. These two characteristics make them ideal instruments for studying the highest energy gamma rays, extended sources and transient phenomena. Until recently air shower arrays have had insufficient sensitivity to detect gamma-ray sources. Over the past decade, the situation has changed markedly. Milagro,more » in the US, and the Tibet AS{gamma} array in Tibet, have detected very-high-energy gamma-ray emission from the Crab Nebula and the active galaxy Markarian 421 (both previously known sources). Milagro has discovered TeV diffuse emission from the Milky Way, three unidentified sources of TeV gamma rays, and several candidate sources of TeV gamma rays. Given these successes and the suite of existing and planned instruments in the GeV and TeV regime (AGILE, GLAST, HESS, VERITAS, CTA, AGIS and IceCube) there are strong reasons for pursuing a next generation of EAS detectors. In conjunction with these other instruments the next generation of EAS instruments could answer long-standing problems in astrophysics.« less

Simulated Cytoskeletal Collapse via Tau Degradation

PubMed Central

Sendek, Austin; Fuller, Henry R.; Hayre, N. Robert; Singh, Rajiv R. P.; Cox, Daniel L.

2014-01-01

We present a coarse-grained two dimensional mechanical model for the microtubule-tau bundles in neuronal axons in which we remove taus, as can happen in various neurodegenerative conditions such as Alzheimers disease, tauopathies, and chronic traumatic encephalopathy. Our simplified model includes (i) taus modeled as entropic springs between microtubules, (ii) removal of taus from the bundles due to phosphorylation, and (iii) a possible depletion force between microtubules due to these dissociated phosphorylated taus. We equilibrate upon tau removal using steepest descent relaxation. In the absence of the depletion force, the transverse rigidity to radial compression of the bundles falls to zero at about 60% tau occupancy, in agreement with standard percolation theory results. However, with the attractive depletion force, spring removal leads to a first order collapse of the bundles over a wide range of tau occupancies for physiologically realizable conditions. While our simplest calculations assume a constant concentration of microtubule intercalants to mediate the depletion force, including a dependence that is linear in the detached taus yields the same collapse. Applying percolation theory to removal of taus at microtubule tips, which are likely to be the protective sites against dynamic instability, we argue that the microtubule instability can only obtain at low tau occupancy, from 0.06–0.30 depending upon the tau coordination at the microtubule tips. Hence, the collapse we discover is likely to be more robust over a wide range of tau occupancies than the dynamic instability. We suggest in vitro tests of our predicted collapse. PMID:25162587

Upper bound on neutrino mass based on T2K neutrino timing measurements

NASA Astrophysics Data System (ADS)

Abe, K.; Adam, J.; Aihara, H.; Akiri, T.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bartet-Friburg, P.; Bass, M.; Batkiewicz, M.; Bay, F.; Berardi, V.; Berger, B. E.; Berkman, S.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Bolognesi, S.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Chikuma, N.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S. R.; Densham, C.; Dewhurst, D.; Di Lodovico, F.; Di Luise, S.; Dolan, S.; Drapier, O.; Duboyski, T.; Duffy, K.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Emery-Schrenk, S.; Ereditato, A.; Escudero, L.; Feusels, T.; Finch, A. J.; Fiorentini, G. A.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Garcia, A.; Giffin, S.; Giganti, C.; Gilje, K.; Goeldi, D.; Golan, T.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haegel, L.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayashino, T.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Hosomi, F.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Iwai, E.; Iwamoto, K.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Jiang, M.; Johnson, R. A.; Johnson, S.; Jo, J. H.; Jonsson, P.; Jung, C. K.; Kabirnezhad, M.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Katori, T.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J.; King, S.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Koch, L.; Koga, T.; Kolaceke, A.; Konaka, A.; Kopylov, A.; Kormos, L. L.; Korzenev, A.; Koshio, Y.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kurjata, R.; Kutter, T.; Lagoda, J.; Lamont, I.; Larkin, E.; Laveder, M.; Lawe, M.; Lazos, M.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Lopez, J. P.; Ludovici, L.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marino, A. D.; Marteau, J.; Martin, J. F.; Martins, P.; Martynenko, S.; Maruyama, T.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Mefodiev, A.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Missert, A.; Miura, M.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nakadaira, T.; Nakahata, M.; Nakamura, K. G.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Nantais, C.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; Nowak, J.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Ovsyannikova, T.; Owen, R. A.; Oyama, Y.; Palladino, V.; Palomino, J. L.; Paolone, V.; Payne, D.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pickard, L.; Pinzon Guerra, E. S.; Pistillo, C.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala-Zezula, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Redij, A.; Reeves, M.; Reinherz-Aronis, E.; Riccio, C.; Rodrigues, P. A.; Rojas, P.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Rychter, A.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schoppmann, S.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shah, R.; Shaker, F.; Shaw, D.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suda, Y.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. K.; Tanaka, H. A.; Tanaka, M. M.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Wakamatsu, K.; Walter, C. W.; Wark, D.; Warzycha, W.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Yoo, J.; Yoshida, K.; Yuan, T.; Yu, M.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.; T2K Collaboration

2016-01-01

The Tokai to Kamioka (T2K) long-baseline neutrino experiment consists of a muon neutrino beam, produced at the J-PARC accelerator, a near detector complex and a large 295-km-distant far detector. The present work utilizes the T2K event timing measurements at the near and far detectors to study neutrino time of flight as a function of derived neutrino energy. Under the assumption of a relativistic relation between energy and time of flight, constraints on the neutrino rest mass can be derived. The sub-GeV neutrino beam in conjunction with timing precision of order tens of ns provide sensitivity to neutrino mass in the few MeV /c2 range. We study the distribution of relative arrival times of muon and electron neutrino candidate events at the T2K far detector as a function of neutrino energy. The 90% C.L. upper limit on the mixture of neutrino mass eigenstates represented in the data sample is found to be mν2<5.6 MeV2/c4 .

Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice.

PubMed

Umeda, Tomohiro; Yamashita, Takenari; Kimura, Tetsuya; Ohnishi, Kiyouhisa; Takuma, Hiroshi; Ozeki, Tomoko; Takashima, Akihiko; Tomiyama, Takami; Mori, Hiroshi

2013-07-01

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is a neurodegenerative disorder caused by mutations in the tau gene. Many mutations identified in FTDP-17 have been shown to affect tau exon 10 splicing in vitro, which presumably causes pathologic imbalances in exon 10(-) [3-repeat (3R)] and exon 10(+) [4-repeat (4R)] tau expression and leads to intracellular inclusions of hyperphosphorylated tau in patient brains. However, no reports have investigated this theory using model mice with a tau intronic mutation. Herein, we generated new transgenic mice harboring the tau intron 10 +16C → T mutation. We prepared a transgene construct containing intronic sequences required for exon 10 splicing in the longest tau isoform cDNA. Although mice bearing the construct without the intronic mutation showed normal developmental changes of the tau isoform from 3R tau to equal amounts of 3R and 4R tau, mice with the mutation showed much higher levels of 4R tau at the adult stage. 4R tau was selectively recovered in insoluble brain fractions in their old age. Furthermore, these mice displayed abnormal tau phosphorylation, synapse loss and dysfunction, memory impairment, glial activation, tangle formation, and neuronal loss in an age-dependent manner. These findings provide the first evidence in a mouse model that a tau intronic mutation-induced imbalance of 3R and 4R tau could be a cause of tauopathy. Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Search for muon neutrino disappearance due to sterile neutrino oscillations with the MINOS/MINOS+ experiment

NASA Astrophysics Data System (ADS)

Todd, J.; Chen, R.; Huang, J.; ">MINOS, neutrino oscillations have successfully explained a wide range of neutrino oscillation data. However, anomalous results, such as the electron antineutrino appearance excesses seen by LSND and MiniBooNE, can be explained by the addition of a sterile neutrino at a larger mass scale than the existing three neutrino mass states. MINOS is a two-detector, long-baseline neutrino oscillation experiment optimized to measure muon neutrino disappearance in the NuMI neutrino beam. MINOS+ is the continuation of the MINOS experiment with the NuMI beam in a medium energy configuration. In the model with one sterile neutrino flavor added to the three active neutrino flavors, a sterile neutrino causing electron antineutrino appearance at LSND and MiniBooNE would also cause muon neutrino disappearance at MINOS. The sterile neutrino signature would be seen as modulations at high energy in the charged-current muon neutrino spectrum and a depletion of events in the neutral current spectrum. These proceedings show new results from fitting neutral-current and charged-current energy spectra from MINOS and MINOS+ data to a neutrino oscillation model assuming one sterile neutrino.

Neutrino Cross Sections

NASA Astrophysics Data System (ADS)

Fields, Laura

2014-03-01

The next generation of neutrino oscillation experiments aims to answer many interesting questions such as whether there is CP violation in the neutrino sector and whether sterile neutrinos exist. These esperiments will require high precision cross section measurements of various neutrino and antineutrino channels. Results and prosepects for such measurements from the MINERvA, MiniBooNE, T2K and ArgoNeuT collaborations will be reviewed.

Astroparticle physics with solar neutrinos

PubMed Central

NAKAHATA, Masayuki

2011-01-01

Solar neutrino experiments observed fluxes smaller than the expectations from the standard solar model. This discrepancy is known as the “solar neutrino problem”. Flux measurements by Super-Kamiokande and SNO have demonstrated that the solar neutrino problem is due to neutrino oscillations. Combining the results of all solar neutrino experiments, parameters for solar neutrino oscillations are obtained. Correcting for the effect of neutrino oscillations, the observed neutrino fluxes are consistent with the prediction from the standard solar model. In this article, results of solar neutrino experiments are reviewed with detailed descriptions of what Kamiokande and Super-Kamiokande have contributed to the history of astroparticle physics with solar neutrino measurements. PMID:21558758

Astroparticle physics with solar neutrinos.

PubMed

Nakahata, Masayuki

2011-01-01

Solar neutrino experiments observed fluxes smaller than the expectations from the standard solar model. This discrepancy is known as the "solar neutrino problem". Flux measurements by Super-Kamiokande and SNO have demonstrated that the solar neutrino problem is due to neutrino oscillations. Combining the results of all solar neutrino experiments, parameters for solar neutrino oscillations are obtained. Correcting for the effect of neutrino oscillations, the observed neutrino fluxes are consistent with the prediction from the standard solar model. In this article, results of solar neutrino experiments are reviewed with detailed descriptions of what Kamiokande and Super-Kamiokande have contributed to the history of astroparticle physics with solar neutrino measurements. (Communicated by Toshimitsu Yamazaki, M.J.A.).

The development of air shower in the iron absorber

NASA Technical Reports Server (NTRS)

Hazama, M.; Dake, S.; Harada, K.; Kawamoto, M.; Sakata, M.; Yamamoto, Y.; Sugihara, T.

1985-01-01

The iron open-sandwich experiments to observe one dimensional development of individual air showers were carried out at Akeno Observatory. One dimensional energy flow, incident energy and production height of shower is estimated using the data of size and age obtained from the above experiment and simple calculation.

Structural peculiarities of the Quadrantid meteor shower

NASA Technical Reports Server (NTRS)

Isamutdinov, Sh. O.; Chebotarev, R. P.

1987-01-01

Systematic radio observations to investigate the Quadrantid meteor shower structure are regularly carried out. They have now been conducted annually in the period of its maximum activity, January 1 to 6, since 1966. The latest results of these investigations are presented, on the basis of 1981 to 1984 data obtained using new equipment with a limiting sensitivity of +7.7 sup m which make it possible to draw some conclusions on the Quadrantids shower structure both for transverse and lengthwise directions.

A measurement of neutrino oscillations with muon neutrinos in the MINOS experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coleman, Stephen James

2011-05-01

Experimental evidence has established that neutrino flavor states evolve over time. A neutrino of a particular flavor that travels some distance can be detected in a different neutrino flavor state. The Main Injector Neutrino Oscillation Search (MINOS) is a long-baseline experiment that is designed to study this phenomenon, called neutrino oscillations. MINOS is based at Fermilab near Chicago, IL, and consists of two detectors: the Near Detector located at Fermilab, and the Far Detector, which is located in an old iron mine in Soudan, MN. Both detectors are exposed to a beam of muon neutrinos from the NuMI beamline, andmore » MINOS measures the fraction of muon neutrinos that disappear after traveling the 734 km between the two detectors. One can measure the atmospheric neutrino mass splitting and mixing angle by observing the energy-dependence of this muon neutrino disappearance. MINOS has made several prior measurements of these parameters. Here I describe recently-developed techniques used to enhance our sensitivity to the oscillation parameters, and I present the results obtained when they are applied to a dataset that is twice as large as has been previously analyzed. We measure the mass splitting Δm 23 2 = (2.32 -0.08 +0.12) x 10 -3 eV 2/c 4 and the mixing angle sin 2(2θ 32) > 0.90 at 90% C.L. These results comprise the world's best measurement of the atmospheric neutrino mass splitting. Alternative disappearance models are also tested. The neutrino decay hypothesis is disfavored at 7.2σ and the neutrino quantum decoherence hypothesis is disfavored at 9.0σ.« less

Thunderstorm observations by air-shower radio antenna arrays

NASA Astrophysics Data System (ADS)

Apel, W. D.; Arteaga, J. C.; Bähren, L.; Bekk, K.; Bertaina, M.; Biermann, P. L.; Blümer, J.; Bozdog, H.; Brancus, I. M.; Buchholz, P.; Buitink, S.; Cantoni, E.; Chiavassa, A.; Daumiller, K.; de Souza, V.; di Pierro, F.; Doll, P.; Ender, M.; Engel, R.; Falcke, H.; Finger, M.; Fuhrmann, D.; Gemmeke, H.; Grupen, C.; Haungs, A.; Heck, D.; Hörandel, J. R.; Horneffer, A.; Huber, D.; Huege, T.; Isar, P. G.; Kampert, K.-H.; Kang, D.; Krömer, O.; Kuijpers, J.; Link, K.; Łuczak, P.; Ludwig, M.; Mathes, H. J.; Melissas, M.; Morello, C.; Nehls, S.; Oehlschläger, J.; Palmieri, N.; Pierog, T.; Rautenberg, J.; Rebel, H.; Roth, M.; Rühle, C.; Saftoiu, A.; Schieler, H.; Schmidt, A.; Schröder, F. G.; Sima, O.; Toma, G.; Trinchero, G. C.; Weindl, A.; Wochele, J.; Wommer, M.; Zabierowski, J.; Zensus, J. A.

2011-10-01

Relativistic, charged particles present in extensive air showers (EAS) lead to a coherent emission of radio pulses which are measured to identify the shower initiating high-energy cosmic rays. Especially during thunderstorms, there are additional strong electric fields in the atmosphere, which can lead to further multiplication and acceleration of the charged particles and thus have influence on the form and strength of the radio emission. For a reliable energy reconstruction of the primary cosmic ray by means of the measured radio signal it is very important to understand how electric fields affect the radio emission. In addition, lightning strikes are a prominent source of broadband radio emissions that are visible over very long distances. This, on the one hand, causes difficulties in the detection of the much lower signal of the air shower. On the other hand the recorded signals can be used to study features of the lightning development. The detection of cosmic rays via the radio emission and the influence of strong electric fields on this detection technique is investigated with the LOPES experiment in Karlsruhe, Germany. The important question if a lightning is initiated by the high electron density given at the maximum of a high-energy cosmic-ray air shower is also investigated, but could not be answered by LOPES. But, these investigations exhibit the capabilities of EAS radio antenna arrays for lightning studies. We report about the studies of LOPES measured radio signals of air showers taken during thunderstorms and give a short outlook to new measurements dedicated to search for correlations of lightning and cosmic rays.

Observation of Cosmic-Ray Anisotropy with the IceTop Air Shower Array

NASA Astrophysics Data System (ADS)

Aartsen, M. G.; Abbasi, R.; Abdou, Y.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Altmann, D.; Andeen, K.; Auffenberg, J.; Bai, X.; Baker, M.; Barwick, S. W.; Baum, V.; Bay, R.; Beattie, K.; Beatty, J. J.; Bechet, S.; Becker Tjus, J.; Becker, K.-H.; Bell, M.; Benabderrahmane, M. L.; BenZvi, S.; Berdermann, J.; Berghaus, P.; Berley, D.; Bernardini, E.; Bertrand, D.; Besson, D. Z.; Bindig, D.; Bissok, M.; Blaufuss, E.; Blumenthal, J.; Boersma, D. J.; Bohaichuk, S.; Bohm, C.; Bose, D.; Böser, S.; Botner, O.; Brayeur, L.; Brown, A. M.; Bruijn, R.; Brunner, J.; Carson, M.; Casey, J.; Casier, M.; Chirkin, D.; Christy, B.; Clark, K.; Clevermann, F.; Cohen, S.; Cowen, D. F.; Cruz Silva, A. H.; Danninger, M.; Daughhetee, J.; Davis, J. C.; De Clercq, C.; De Ridder, S.; Descamps, F.; Desiati, P.; de Vries-Uiterweerd, G.; DeYoung, T.; Díaz-Vélez, J. C.; Dreyer, J.; Dumm, J. P.; Dunkman, M.; Eagan, R.; Eisch, J.; Ellsworth, R. W.; Engdegård, O.; Euler, S.; Evenson, P. A.; Fadiran, O.; Fazely, A. R.; Fedynitch, A.; Feintzeig, J.; Feusels, T.; Filimonov, K.; Finley, C.; Fischer-Wasels, T.; Flis, S.; Franckowiak, A.; Franke, R.; Frantzen, K.; Fuchs, T.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Gladstone, L.; Glüsenkamp, T.; Goldschmidt, A.; Golup, G.; Goodman, J. A.; Góra, D.; Grant, D.; Gross, A.; Grullon, S.; Gurtner, M.; Ha, C.; Haj Ismail, A.; Hallgren, A.; Halzen, F.; Hanson, K.; Heereman, D.; Heimann, P.; Heinen, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Homeier, A.; Hoshina, K.; Huelsnitz, W.; Hulth, P. O.; Hultqvist, K.; Hussain, S.; Ishihara, A.; Jacobi, E.; Jacobsen, J.; Japaridze, G. S.; Jlelati, O.; Kappes, A.; Karg, T.; Karle, A.; Kiryluk, J.; Kislat, F.; Kläs, J.; Klein, S. R.; Köhne, J.-H.; Kohnen, G.; Kolanoski, H.; Köpke, L.; Kopper, C.; Kopper, S.; Koskinen, D. J.; Kowalski, M.; Krasberg, M.; Kroll, G.; Kunnen, J.; Kurahashi, N.; Kuwabara, T.; Labare, M.; Landsman, H.; Larson, M. J.; Lauer, R.; Lesiak-Bzdak, M.; Lünemann, J.; Madsen, J.; Maruyama, R.; Mase, K.; Matis, H. S.; McNally, F.; Meagher, K.; Merck, M.; Mészáros, P.; Meures, T.; Miarecki, S.; Middell, E.; Milke, N.; Miller, J.; Mohrmann, L.; Montaruli, T.; Morse, R.; Nahnhauer, R.; Naumann, U.; Nowicki, S. C.; Nygren, D. R.; Obertacke, A.; Odrowski, S.; Olivas, A.; Olivo, M.; O'Murchadha, A.; Panknin, S.; Paul, L.; Pepper, J. A.; Pérez de los Heros, C.; Pieloth, D.; Pirk, N.; Posselt, J.; Price, P. B.; Przybylski, G. T.; Rädel, L.; Rawlins, K.; Redl, P.; Resconi, E.; Rhode, W.; Ribordy, M.; Richman, M.; Riedel, B.; Rodrigues, J. P.; Rothmaier, F.; Rott, C.; Ruhe, T.; Ruzybayev, B.; Ryckbosch, D.; Saba, S. M.; Salameh, T.; Sander, H.-G.; Santander, M.; Sarkar, S.; Schatto, K.; Scheel, M.; Scheriau, F.; Schmidt, T.; Schmitz, M.; Schoenen, S.; Schöneberg, S.; Schönherr, L.; Schönwald, A.; Schukraft, A.; Schulte, L.; Schulz, O.; Seckel, D.; Seo, S. H.; Sestayo, Y.; Seunarine, S.; Sheremata, C.; Smith, M. W. E.; Soiron, M.; Soldin, D.; Spiczak, G. M.; Spiering, C.; Stamatikos, M.; Stanev, T.; Stasik, A.; Stezelberger, T.; Stokstad, R. G.; Stössl, A.; Strahler, E. A.; Ström, R.; Sullivan, G. W.; Taavola, H.; Taboada, I.; Tamburro, A.; Ter-Antonyan, S.; Tilav, S.; Toale, P. A.; Toscano, S.; Usner, M.; van der Drift, D.; van Eijndhoven, N.; Van Overloop, A.; van Santen, J.; Vehring, M.; Voge, M.; Vraeghe, M.; Walck, C.; Waldenmaier, T.; Wallraff, M.; Walter, M.; Wasserman, R.; Weaver, Ch.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wiebe, K.; Wiebusch, C. H.; Williams, D. R.; Wissing, H.; Wolf, M.; Wood, T. R.; Woschnagg, K.; Xu, C.; Xu, D. L.; Xu, X. W.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Zarzhitsky, P.; Ziemann, J.; Zierke, S.; Zilles, A.; Zoll, M.; IceCube Collaboration

2013-03-01

We report on the observation of anisotropy in the arrival direction distribution of cosmic rays at PeV energies. The analysis is based on data taken between 2009 and 2012 with the IceTop air shower array at the south pole. IceTop, an integral part of the IceCube detector, is sensitive to cosmic rays between 100 TeV and 1 EeV. With the current size of the IceTop data set, searches for anisotropy at the 10-3 level can, for the first time, be extended to PeV energies. We divide the data set into two parts with median energies of 400 TeV and 2 PeV, respectively. In the low energy band, we observe a strong deficit with an angular size of about 30° and an amplitude of (- 1.58 ± 0.46stat ± 0.52sys) × 10-3 at a location consistent with previous observations of cosmic rays with the IceCube neutrino detector. The study of the high energy band shows that the anisotropy persists to PeV energies and increases in amplitude to (- 3.11 ± 0.38stat ± 0.96sys) × 10-3.

Neutrino physics with JUNO

NASA Astrophysics Data System (ADS)

An, Fengpeng; An, Guangpeng; An, Qi; Antonelli, Vito; Baussan, Eric; Beacom, John; Bezrukov, Leonid; Blyth, Simon; Brugnera, Riccardo; Buizza Avanzini, Margherita; Busto, Jose; Cabrera, Anatael; Cai, Hao; Cai, Xiao; Cammi, Antonio; Cao, Guofu; Cao, Jun; Chang, Yun; Chen, Shaomin; Chen, Shenjian; Chen, Yixue; Chiesa, Davide; Clemenza, Massimiliano; Clerbaux, Barbara; Conrad, Janet; D'Angelo, Davide; De Kerret, Hervé; Deng, Zhi; Deng, Ziyan; Ding, Yayun; Djurcic, Zelimir; Dornic, Damien; Dracos, Marcos; Drapier, Olivier; Dusini, Stefano; Dye, Stephen; Enqvist, Timo; Fan, Donghua; Fang, Jian; Favart, Laurent; Ford, Richard; Göger-Neff, Marianne; Gan, Haonan; Garfagnini, Alberto; Giammarchi, Marco; Gonchar, Maxim; Gong, Guanghua; Gong, Hui; Gonin, Michel; Grassi, Marco; Grewing, Christian; Guan, Mengyun; Guarino, Vic; Guo, Gang; Guo, Wanlei; Guo, Xin-Heng; Hagner, Caren; Han, Ran; He, Miao; Heng, Yuekun; Hsiung, Yee; Hu, Jun; Hu, Shouyang; Hu, Tao; Huang, Hanxiong; Huang, Xingtao; Huo, Lei; Ioannisian, Ara; Jeitler, Manfred; Ji, Xiangdong; Jiang, Xiaoshan; Jollet, Cécile; Kang, Li; Karagounis, Michael; Kazarian, Narine; Krumshteyn, Zinovy; Kruth, Andre; Kuusiniemi, Pasi; Lachenmaier, Tobias; Leitner, Rupert; Li, Chao; Li, Jiaxing; Li, Weidong; Li, Weiguo; Li, Xiaomei; Li, Xiaonan; Li, Yi; Li, Yufeng; Li, Zhi-Bing; Liang, Hao; Lin, Guey-Lin; Lin, Tao; Lin, Yen-Hsun; Ling, Jiajie; Lippi, Ivano; Liu, Dawei; Liu, Hongbang; Liu, Hu; Liu, Jianglai; Liu, Jianli; Liu, Jinchang; Liu, Qian; Liu, Shubin; Liu, Shulin; Lombardi, Paolo; Long, Yongbing; Lu, Haoqi; Lu, Jiashu; Lu, Jingbin; Lu, Junguang; Lubsandorzhiev, Bayarto; Ludhova, Livia; Luo, Shu; Lyashuk, Vladimir; Möllenberg, Randolph; Ma, Xubo; Mantovani, Fabio; Mao, Yajun; Mari, Stefano M.; McDonough, William F.; Meng, Guang; Meregaglia, Anselmo; Meroni, Emanuela; Mezzetto, Mauro; Miramonti, Lino; Mueller, Thomas; Naumov, Dmitry; Oberauer, Lothar; Ochoa-Ricoux, Juan Pedro; Olshevskiy, Alexander; Ortica, Fausto; Paoloni, Alessandro; Peng, Haiping; Peng, Jen-Chieh; Previtali, Ezio; Qi, Ming; Qian, Sen; Qian, Xin; Qian, Yongzhong; Qin, Zhonghua; Raffelt, Georg; Ranucci, Gioacchino; Ricci, Barbara; Robens, Markus; Romani, Aldo; Ruan, Xiangdong; Ruan, Xichao; Salamanna, Giuseppe; Shaevitz, Mike; Sinev, Valery; Sirignano, Chiara; Sisti, Monica; Smirnov, Oleg; Soiron, Michael; Stahl, Achim; Stanco, Luca; Steinmann, Jochen; Sun, Xilei; Sun, Yongjie; Taichenachev, Dmitriy; Tang, Jian; Tkachev, Igor; Trzaska, Wladyslaw; van Waasen, Stefan; Volpe, Cristina; Vorobel, Vit; Votano, Lucia; Wang, Chung-Hsiang; Wang, Guoli; Wang, Hao; Wang, Meng; Wang, Ruiguang; Wang, Siguang; Wang, Wei; Wang, Yi; Wang, Yi; Wang, Yifang; Wang, Zhe; Wang, Zheng; Wang, Zhigang; Wang, Zhimin; Wei, Wei; Wen, Liangjian; Wiebusch, Christopher; Wonsak, Björn; Wu, Qun; Wulz, Claudia-Elisabeth; Wurm, Michael; Xi, Yufei; Xia, Dongmei; Xie, Yuguang; Xing, Zhi-zhong; Xu, Jilei; Yan, Baojun; Yang, Changgen; Yang, Chaowen; Yang, Guang; Yang, Lei; Yang, Yifan; Yao, Yu; Yegin, Ugur; Yermia, Frédéric; You, Zhengyun; Yu, Boxiang; Yu, Chunxu; Yu, Zeyuan; Zavatarelli, Sandra; Zhan, Liang; Zhang, Chao; Zhang, Hong-Hao; Zhang, Jiawen; Zhang, Jingbo; Zhang, Qingmin; Zhang, Yu-Mei; Zhang, Zhenyu; Zhao, Zhenghua; Zheng, Yangheng; Zhong, Weili; Zhou, Guorong; Zhou, Jing; Zhou, Li; Zhou, Rong; Zhou, Shun; Zhou, Wenxiong; Zhou, Xiang; Zhou, Yeling; Zhou, Yufeng; Zou, Jiaheng

2016-03-01

The Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton multi-purpose underground liquid scintillator detector, was proposed with the determination of the neutrino mass hierarchy (MH) as a primary physics goal. The excellent energy resolution and the large fiducial volume anticipated for the JUNO detector offer exciting opportunities for addressing many important topics in neutrino and astro-particle physics. In this document, we present the physics motivations and the anticipated performance of the JUNO detector for various proposed measurements. Following an introduction summarizing the current status and open issues in neutrino physics, we discuss how the detection of antineutrinos generated by a cluster of nuclear power plants allows the determination of the neutrino MH at a 3-4σ significance with six years of running of JUNO. The measurement of antineutrino spectrum with excellent energy resolution will also lead to the precise determination of the neutrino oscillation parameters {{sin}}2{θ }12, {{Δ }}{m}212, and | {{Δ }}{m}{ee}2| to an accuracy of better than 1%, which will play a crucial role in the future unitarity test of the MNSP matrix. The JUNO detector is capable of observing not only antineutrinos from the power plants, but also neutrinos/antineutrinos from terrestrial and extra-terrestrial sources, including supernova burst neutrinos, diffuse supernova neutrino background, geoneutrinos, atmospheric neutrinos, and solar neutrinos. As a result of JUNO's large size, excellent energy resolution, and vertex reconstruction capability, interesting new data on these topics can be collected. For example, a neutrino burst from a typical core-collapse supernova at a distance of 10 kpc would lead to ˜5000 inverse-beta-decay events and ˜2000 all-flavor neutrino-proton ES events in JUNO, which are of crucial importance for understanding the mechanism of supernova explosion and for exploring novel phenomena such as collective neutrino oscillations

16 CFR 1201.40 - Interpretation concerning bathtub and shower doors and enclosures.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Interpretation concerning bathtub and shower... Policy and Interpretation § 1201.40 Interpretation concerning bathtub and shower doors and enclosures. (a... and enclosures” and “shower door and enclosure” as they are used in the Standard in subpart A. The...

Electromagnetic Showers at High Energy

ERIC Educational Resources Information Center

Loos, J. S.; Dawson, S. L.

1978-01-01

Some of the properties of electromagnetic showers observed in an experimental study are illustrated. Experimental data and results from quantum electrodynamics are discussed. Data and theory are compared using computer simulation. (BB)

Neutrino Oscillations Physics

NASA Astrophysics Data System (ADS)

Fogli, Gianluigi

2005-06-01

We review the status of the neutrino oscillations physics, with a particular emphasis on the present knowledge of the neutrino mass-mixing parameters. We consider first the νμ → ντ flavor transitions of atmospheric neutrinos. It is found that standard oscillations provide the best description of the SK+K2K data, and that the associated mass-mixing parameters are determined at ±1σ (and NDF = 1) as: Δm2 = (2.6 ± 0.4) × 10-3 eV2 and sin 2 2θ = 1.00{ - 0.05}{ + 0.00} . Such indications, presently dominated by SK, could be strengthened by further K2K data. Then we point out that the recent data from the Sudbury Neutrino Observatory, together with other relevant measurements from solar and reactor neutrino experiments, in particular the KamLAND data, convincingly show that the flavor transitions of solar neutrinos are affected by Mikheyev-Smirnov-Wolfenstein (MSW) effects. Finally, we perform an updated analysis of two-family active oscillations of solar and reactor neutrinos in the standard MSW case.

Measurement of neutrino flux from neutrino-electron elastic scattering

DOE PAGES

Park, J.; Aliaga, L.; Altinok, O.; ...

2016-06-10

Muon-neutrino elastic scattering on electrons is an observable neutrino process whose cross section is precisely known. Consequently, a measurement of this process in an accelerator-based ν μ beam can improve the knowledge of the absolute neutrino flux impinging upon the detector; typically this knowledge is limited to ~10% due to uncertainties in hadron production and focusing. We also isolated a sample of 135±17 neutrino-electron elastic scattering candidates in the segmented scintillator detector of MINERvA, after subtracting backgrounds and correcting for efficiency. We show how this sample can be used to reduce the total uncertainty on the NuMI ν μ fluxmore » from 9% to 6%. Finally, our measurement provides a flux constraint that is useful to other experiments using the NuMI beam, and this technique is applicable to future neutrino beams operating at multi-GeV energies.« less

Measurement of neutrino flux from neutrino-electron elastic scattering

NASA Astrophysics Data System (ADS)

Park, J.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Budd, H.; Cai, T.; Carneiro, M. F.; Christy, M. E.; Chvojka, J.; da Motta, H.; Dytman, S. A.; Díaz, G. A.; Eberly, B.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; Martinez Caicedo, D. A.; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman; Osta, J.; Paolone, V.; Patrick, C. E.; Perdue, G. N.; Rakotondravohitra, L.; Ramirez, M. A.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Solano Salinas, C. J.; Tagg, N.; Tice, B. G.; Valencia, E.; Walton, T.; Wolcott, J.; Wospakrik, M.; Zavala, G.; Zhang, D.; Miner ν A Collaboration

2016-06-01

Muon-neutrino elastic scattering on electrons is an observable neutrino process whose cross section is precisely known. Consequently a measurement of this process in an accelerator-based νμ beam can improve the knowledge of the absolute neutrino flux impinging upon the detector; typically this knowledge is limited to ˜10 % due to uncertainties in hadron production and focusing. We have isolated a sample of 135 ±17 neutrino-electron elastic scattering candidates in the segmented scintillator detector of MINERvA, after subtracting backgrounds and correcting for efficiency. We show how this sample can be used to reduce the total uncertainty on the NuMI νμ flux from 9% to 6%. Our measurement provides a flux constraint that is useful to other experiments using the NuMI beam, and this technique is applicable to future neutrino beams operating at multi-GeV energies.

Radar observations of the Volantids meteor shower

NASA Astrophysics Data System (ADS)

Younger, J.; Reid, I.; Murphy, D.

2016-01-01

A new meteor shower occurring for the first time on 31 December 2015 in the constellation Volans was identified by the CAMS meteor video network in New Zealand. Data from two VHF meteor radars located in Australia and Antarctica have been analyzed using the great circle method to search for Volantids activity. The new shower was found to be active for at least three days over the period 31 December 2015 - 2 January 2016, peaking at an apparent radiant of R.A. = 119.3 ± 3.7, dec. = -74.5 ± 1.9 on January 1st. Measurements of meteoroid velocity were made using the Fresnel transform technique, yielding a geocentric shower velocity of 28.1 ± 1.8 km s-1. The orbital parameters for the parent stream are estimated to be a = 2.11 AU, e = 0.568, i = 47.2°, with a perihelion distance of q = 0.970 AU.

Tau-imaging in neurodegeneration.

PubMed

Bischof, Gérard N; Endepols, Heike; van Eimeren, Thilo; Drzezga, Alexander

2017-11-01

Pathological cerebral aggregations of proteins are suggested to play a crucial role in the development of neurodegenerative disorders. For example, aggregation of the protein ß-amyloid in form of extracellular amyloid-plaques as well as intraneuronal depositions of the protein tau in form of neurofibrillary tangles represent hallmarks of Alzheimer's disease (AD). Recently, novel tracers for in vivo molecular imaging of tau-aggregates in the brain have been introduced, complementing existing tracers for imaging amyloid-plaques. Available data on these novel tracers indicate that the subject of Tau-PET may be of considerable complexity. On the one hand this refers to the various forms of appearance of tau-pathology in different types of neurodegenerative disorders. On the other hand, a number of hurdles regarding validation of these tracers still need to be overcome with regard to comparability and standardization of the different tracers, observed off-target/non-specific binding and quantitative interpretation of the signal. These issues will have to be clarified before systematic clinical application of this exciting new methodological approach may become possible. Potential applications refer to early detection of neurodegeneration, differential diagnosis between tauopathies and non-tauopathies and specific patient selection and follow-up in therapy trials. Copyright © 2017. Published by Elsevier Inc.

Showering effectiveness for human hair decontamination of the nerve agent VX.

PubMed

Josse, Denis; Wartelle, Julien; Cruz, Catherine

2015-05-05

In this work, our goals were to establish whether hair decontamination by showering one hour post-exposure to the highly toxic organophosphate nerve agent VX was effective, whether it required the addition of a detergent to water and, if it could be improved by using the adsorbent Fuller's Earth (FE) or the Reactive Skin Decontamination Lotion (RSDL) 30 min prior to showering. Hair exposure to VX and decontamination was performed by using an in vitro model. Hair showering led to 72% reduction of contamination. Addition of detergent to water slightly increased the decontamination effectiveness. Hair treatment with FE or RSDL improved the decontamination rate. Combination of FE use and showering, which yielded a decontamination factor of 41, was demonstrated to be the most effective hair decontamination procedure. Hair wiping after showering was shown to contribute to hair decontamination. Altogether, our results highlighted the importance of considering hair decontamination as an important part of body surface decontamination protocols. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Effect of collisions on neutrino flavor inhomogeneity in a dense neutrino gas

DOE PAGES

Cirigliano, Vincenzo; Paris, Mark W.; Shalgar, Shashank

2017-09-25

We investigate the stability, with respect to spatial inhomogeneity, of a two-dimensional dense neutrino gas. The system exhibits growth of seed inhomogeneity due to nonlinear coherent neutrino self-interactions. In the absence of incoherent collisional effects, we also observe a dependence of this instability growth rate on the neutrino mass spectrum: the normal neutrino mass hierarchy exhibits spatial instability over a larger range of neutrino number density compared to that of the inverted case. Furthermore, we consider the effect of elastic incoherent collisions of the neutrinos with a static background of heavy, nucleon-like scatterers. At small scales, the growth of flavormore » instability can be suppressed by collisions. At large length scales we find, perhaps surprisingly, that for inverted neutrino mass hierarchy incoherent collisions fail to suppress flavor instabilities, independent of the coupling strength.« less

TIERRAS: A package to simulate high energy cosmic ray showers underground, underwater and under-ice

NASA Astrophysics Data System (ADS)

Tueros, Matías; Sciutto, Sergio

2010-02-01

1 km of standard rock (or 2.5 km of water equivalent). Neutrinos are not tracked on the simulation, but their energy is taken into account in decays. Running time: A TIERRAS for AIRES run of a 10 eV shower with statistical sampling (thinning) below 10 eV and 0.2 weight factor (see [1]) uses approximately 1 h of CPU time on an Intel Core 2 Quad Q6600 at 2.4 GHz. It uses only one core, so 4 simultaneous simulations can be run on this computer. Aires includes a spooling system to run several simultaneous jobs of any type. References:S. Sciutto, AIRES 2.6 User Manual, http://www.fisica.unlp.edu.ar/auger/aires/.

The activity of autumn meteor showers in 2006-2008

NASA Astrophysics Data System (ADS)

Kartashova, Anna

2015-03-01

The purpose of meteor observations in INASAN is the study of meteor showers, as the elements of the migrant substance of the Solar System, and estimation of risk of hazardous collisions of spacecrafts with the particles of streams. Therefore we need to analyze the meteor events with brightness of up to 8 m, which stay in meteoroid streams for a long time and can be a hazardous for the spacecraft. The results of our single station TV observations of autumn meteor showers for the period from 2006 to 2008 are presented. The high-sensitive hybrid camera (the system with coupled of the Image Intensifier) FAVOR with limiting magnitude for meteors about 9m. . .10m in the field of view 20 × 18 was used for observations. In 2006-2008 from October to November more than 3 thousand of meteors were detected, 65% from them have the brightness from 6m to 9m. The identification with autumn meteor showers (Orionids, Taurids, Draconids, Leonids) was carried out. In order to estimate the density of the influx of meteor matter to the Earth for these meteor showers the Index of meteor activity (IMA) was calculated. The IMA distribution for the period 2006 - 2008 is given. The distributions of autumn meteor showers (the meteors with brightness of up to 8 m) by stellar magnitude from 2006 to 2008 are also presented.

Review: Tau in biofluids - relation to pathology, imaging and clinical features.

PubMed

Zetterberg, H

2017-04-01

Tau is a microtubule-binding protein that is important for the stability of neuronal axons. It is normally expressed within neurons and is also secreted into the brain interstitial fluid that communicates freely with cerebrospinal fluid (CSF) and, in a more restricted manner, blood via the glymphatic clearance system of the brain. In Alzheimer's disease (AD), neuroaxonal degeneration results in increased release of tau from neurons. Furthermore, tau is truncated and phosphorylated, which leads to aggregation of tau in neurofibrillary tangles of the proximal axoplasm. Neuroaxonal degeneration and tangle formation are reflected by increased concentrations of total tau (T-tau, measured using assays that detect most forms of tau) and phospho-tau (P-tau, measured using assays with antibodies specific to phosphorylated forms of tau). In AD CSF, both T-tau and P-tau concentrations are increased. In stroke and other CNS disorders with neuroaxonal injury but without tangles, T-tau is selectively increased, whereas P-tau concentration often stays normal. In tauopathies (diseases with both neurodegeneration and neurofibrillary tangles) other than AD, CSF T-tau and P-tau concentrations are typically unaltered, which is a puzzling result that warrants further investigation. In the current review, I discuss the association of T-tau and P-tau concentrations in body fluids with neuropathological changes, imaging findings and clinical features in AD and other CNS diseases. © 2017 British Neuropathological Society.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorham, P.W.; /Hawaii U.; Allison, P.

We report initial results of the Antarctic Impulsive Transient Antenna (ANITA) 2006-2007 Long Duration Balloon flight, which searched for evidence of the flux of cosmogenic neutrinos. ANITA flew for 35 days looking for radio impulses that might be due to the Askaryan effect in neutrino-induced electromagnetic showers within the Antarctic ice sheets. In our initial high-threshold robust analysis, no neutrino candidates are seen, with no physics background. In a non-signal horizontal-polarization channel, we do detect 6 events consistent with radio impulses from extensive air showers, which helps to validate the effectiveness of our method. Upper limits derived from our analysismore » now begin to eliminate the highest cosmogenic neutrino models.« less

The 2018 Meteor Shower Activity Forecast for Earth Orbit

NASA Technical Reports Server (NTRS)

Moorhead, Althea; Cooke, Bill; Moser, Danielle

2017-01-01

A number of meteor showers - the Ursids, Perseids, Leonids, eta Aquariids, Orionids, Draconids, and Andromedids - are predicted to exhibit increased rates in 2018. However, no major storms are predicted, and none of these enhanced showers outranks the typical activity of the Arietids, Southern delta Aquariids, and Geminids at small particle sizes. The MSFC stream model1 predicts higher than usual activity for the Ursid meteor shower in December 2018. While we expect an increase in activity, rates will fall short of the shower's historical outbursts in 1945 and 1986 when the zenithal hourly rate (ZHR) exceeded 100. Instead, the expected rate for 2018 is around 70. The Perseids, Leonids, eta Aquariids, and Orionids are expected to show mild enhancements over their baseline activity level in 2018. In the case of the Perseids, we may see an additional peak in activity a few hours before the traditional peak, but we do not expect activity levels as high as those seen in 2016 and 2017. The eta Aquariids and Orionids, which belong to a single meteoroid stream generated by comet 1P/Halley, are thought to have a 12-year activity cycle and are currently increasing in activity from year to year. Finally, we may see minor outbursts of the Draconids and Andromedids in 2018. Both showers have been difficult to model and have produced unexpected outbursts in recent years (the Draconids in 2012 and the Andromedids in 2011 and 2013). The Andromedids may produce two peaks, both of which are listed in Table 2. This document is designed to supplement spacecraft risk assessments that incorporate an annual averaged meteor shower flux (as is the case with all NASA meteoroid models). Results are presented relative to this baseline and are weighted to a constant kinetic energy. Two showers - the Daytime Arietids (ARI) and the Geminids (GEM) - attain flux levels approaching that of the baseline meteoroid environment for 0.1-cm-equivalent meteoroids. This size is the threshold for structural

Neutrino-oscillation search with cosmic-ray neutrinos

NASA Astrophysics Data System (ADS)

Ayres, D. S.; Cortez, B.; Gaisser, T. K.; Mann, A. K.; Shrock, R. E.; Sulak, L. R.

1984-03-01

A sensitive search for neutrino oscillations involving νe, νμ, and ντ may be provided by measurements of the ratio of the total interaction rates of upward- and downward-going cosmic-ray neutrinos within a massive (~10 kton) detector. Assuming mixing between all pairs of νe, νμ, and ντ, the experiment is capable of observing time-averaged probabilities t and t of magnitude set by mixing strengths corresponding to, e.g., the d- to s-quark mixing strength, and of reaching the limit Δm2ij≡|mi2-mj2|~10-4 eV2, where mi, and mj are neutrino mass eigenstates, and Peτ and Pμτ are the probabilities for νe and νμ, respectively, to oscillate into ντ after traversing a distance L~ diameter of the Earth. Possible ambiguities may be resolved through comparison of the ratios NeNμ for the upward- and downward-going neutrinos.

Neutrino Physics at Fermilab

ScienceCinema

Saoulidou, Niki

2017-12-09

Neutrino oscillations provide the first evidence for physics beyond the Standard Model. I will briefly overview the neutrino "hi-story", describing key discoveries over the past decades that shaped our understanding of neutrinos and their behavior. Fermilab was, is and hopefully will be at the forefront of the accelerator neutrino experiments.  NuMI, the most powerful accelerator neutrino beam in the world has ushered us into the era of precise measurements. Its further upgrades may give a chance to tackle the remaining mysteries of the neutrino mass hierarchy and possible CP violation.

Search for sterile neutrinos in gallium experiments with artificial neutrino sources

NASA Astrophysics Data System (ADS)

Gavrin, V. N.; Cleveland, B. T.; Gorbachev, V. V.; Ibragimova, T. V.; Kalikhov, A. V.; Kozlova, Yu. P.; Mirmov, I. N.; Shikhin, A. A.; Veretenkin, E. P.

2017-11-01

The possibility of the BEST experiment on electron neutrino disappearance with intense artificial sources of electron neutrino 51Cr is considered. BEST has the great potential to search for transitions of active neutrinos to sterile states with Δ m 2 ˜ 1 eV2 and to set the limits on short baseline electron neutrino disappearance oscillation parameters. The possibility of the further constraints the oscillation parameters region with using 65Zn source is discussed.