Big World of Small Neutrinos

Science.gov Websites

electron neutrino, muon neutrino, or tau neutrino. The three different neutrinos are complemented by anti of the neutrinos we detect will look different (have a different flavor) compared to the time they Big World of Small Neutrinos Neutrinos will find you! Fig 1: Hubble image of the deep field

Five years of searches for point sources of astrophysical neutrinos with the AMANDA-II neutrino telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Achterberg, A.; Duvoort, M. R.; Heise, J.

2007-05-15

We report the results of a five-year survey of the northern sky to search for point sources of high energy neutrinos. The search was performed on the data collected with the AMANDA-II neutrino telescope in the years 2000 to 2004, with a live time of 1001 days. The sample of selected events consists of 4282 upward going muon tracks with high reconstruction quality and an energy larger than about 100 GeV. We found no indication of point sources of neutrinos and set 90% confidence level flux upper limits for an all-sky search and also for a catalog of 32 selectedmore » sources. For the all-sky search, our average (over declination and right ascension) experimentally observed upper limit {phi}{sup 0}=((E/1 TeV)){sup {gamma}}{center_dot}(d{phi}/dE) to a point source flux of muon and tau neutrino (detected as muons arising from taus) is {phi}{sub {nu}{sub {mu}}+{nu}{sub {mu}}{sup 0}}+{phi}{sub {nu}{sub {tau}}+{nu}{sub {tau}}}{sup 0}=11.1x 10{sup -11} TeV{sup -1} cm{sup -2} s{sup -1}, in the energy range between 1.6 TeV and 2.5 PeV for a flavor ratio {phi}{sub {nu}{sub {mu}}+{nu}{sub {mu}}{sup 0}}/{phi}{sub {nu}{sub {tau}}+{nu}{sub {tau}}}{sup 0}=1 and assuming a spectral index {gamma}=2. It should be noticed that this is the first time we set upper limits to the flux of muon and tau neutrinos. In previous papers we provided muon neutrino upper limits only neglecting the sensitivity to a signal from tau neutrinos, which improves the limits by 10% to 16%. The value of the average upper limit presented in this work corresponds to twice the limit on the muon neutrino flux {phi}{sub {nu}{sub {mu}}+{nu}{sub {mu}}}{sup 0}=5.5x10{sup -11} TeV{sup -1} cm{sup -2} s{sup -1}. A stacking analysis for preselected active galactic nuclei and a search based on the angular separation of the events were also performed. We report the most stringent flux upper limits to date, including the results of a detailed assessment of systematic uncertainties.« less

A New Neutrino Oscillation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parke, Stephen J.; /Fermilab

2011-07-01

Starting in the late 1960s, neutrino detectors began to see signs that neutrinos, now known to come in the flavors electron ({nu}{sub e}), muon ({nu}{sub {mu}}), and tau ({nu}{sub {tau}}), could transform from one flavor to another. The findings implied that neutrinos must have mass, since massless particles travel at the speed of light and their clocks, so to speak, don't tick, thus they cannot change. What has since been discovered is that neutrinos oscillate at two distinct scales, 500 km/GeV and 15,000 km/GeV, which are defined by the baseline (L) of the experiment (the distance the neutrino travels) dividedmore » by the neutrino energy (E). Neutrinos of one flavor can oscillate into neutrinos of another flavor at both L/E scales, but the amplitude of these oscillations is different for the two scales and depends on the initial and final flavor of the neutrinos. The neutrino states that propogate unchanged in time, the mass eigenstates {nu}1, {nu}2, {nu}3, are quantum mechanical mixtures of the electron, muon, and tau neutrino flavors, and the fraction of each flavor in a given mass eigenstate is controlled by three mixing angles and a complex phase. Two of these mixing angles are known with reasonable precision. An upper bound exists for the third angle, called {theta}{sub 13}, which controls the size of the muon neutrino to electron neutrino oscillation at an L/E of 500 km/GeV. The phase is completely unknown. The existence of this phase has important implications for the asymmetry between matter and antimatter we observe in the universe today. Experiments around the world have steadily assembled this picture of neutrino oscillation, but evidence of muon neutrino to electron neutrino oscillation at 500 km/GeV has remained elusive. Now, a paper from the T2K (Tokai to Kamioka) experiment in Japan, reports the first possible observation of muon neutrinos oscillating into electron neutrinos at 500 km/GeV. They see 6 candidate signal events, above an expected

Atmospheric neutrinos and proton decay in Super-Kamiokande and Hyper-Kamiokande

NASA Astrophysics Data System (ADS)

Li, Zepeng; Super-Kamiokande Collaboration; Hyper-Kamiokande Collaboration

2017-06-01

Super-Kamiokande is a 50 kton water Cherenkov detector, which has been in operation since 1996. Super-Kamiokande atmospheric neutrino data have a preference for the normal neutrino mass hierarchy (Δχ2 = χNH2- χIH2 = - 4.3) when the constraints from reactor neutrino experiments are included. The search for tau neutrino appearance from neutrino oscillations has resulted in a 4.6σ exclusion of the hypothesis of no tau appearance. Hyper-Kamiokande is a proposed next-generation water Cherenkov detector, which will be a natural extension of Super-Kamiokande. The proposed experiment will have two cylindrical tanks containing 520 kton of water in total. Hyper-K will search for CP violation using the neutrino beam from J-PARC, and will have a broad physics program including studies of atmospheric neutrinos, supernova burst neutrinos, geo-neutrinos and searches for proton decay.

Search for sterile neutrino mixing in the muon neutrino to tau neutrino appearance channel with the OPERA detector

NASA Astrophysics Data System (ADS)

Di Crescenzo, A.; OPERA Collaboration

2016-05-01

The OPERA experiment observed ν μ → ν τ oscillations in the atmospheric sector. To this purpose the hybrid OPERA detector was exposed to the CERN Neutrinos to Gran Sasso beam from 2008 to 2012, at a distance of 730 km from the neutrino source. Charged-current interactions of ν τ were searched for through the identification of τ lepton decay topologies. The five observed ν τ interactions are consistent with the expected number of events in the standard three neutrino framework. Based on this result, new limits on the mixing parameters of a massive sterile neutrino may be set. Preliminary results of the analysis performed in the 3+1 neutrino framework are here presented.

Radiative decay of massious neutrinos: Implications for physics and astrophysics

NASA Technical Reports Server (NTRS)

Stecker, F. W.

1981-01-01

The radiative lifetime tau for the decay of massious neutrinos is calculated using various physical models for neutrino decay. The results are related to the astrophysical problem of the detectability of the decay photons from cosmic neutrinos. Conversely, the astrophysical data are used to place lower limits on tau. However, an observed feature at approximately 1700 A in the ultraviolet background radiation at high galactic latitudes may be from the decay of neutrinos with mass approximately 14 eV. This would require a decay rate much larger than the predictions of standard models but could be indicative of a decay rate possible in composite models. It is considered that this may be an important test for substructure in leptons and quarks.

Friedberg-Lee symmetry and tribimaximal neutrino mixing in the inverse seesaw mechanism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chan, A.H.; Institute of Advanced Studies, Nanyang Technological University, Singapore 639673; Department of Physics, National University of Singapore, Singapore 117542

2009-10-01

The inverse seesaw mechanism with three pairs of gauge-singlet neutrinos offers a natural interpretation of the tiny masses of three active neutrinos at the TeV scale. We combine this picture with the newly proposed Friedberg-Lee (FL) symmetry in order to understand the observed pattern of neutrino mixing. We show that the FL symmetry requires only two pairs of the gauge-singlet neutrinos to be massive, implying that one active neutrino must be massless. We propose a phenomenological ansatz with broken FL symmetry and exact {mu}-{tau} symmetry in the gauge-singlet neutrino sector, and obtain the tribimaximal neutrino mixing pattern by means ofmore » the inverse seesaw relation. We demonstrate that nonunitary corrections to this result can possibly reach the percent level, and a soft breaking of {mu}-{tau} symmetry can give rise to CP violation in such a TeV-scale seesaw scenario.« less

Mu- and Tau-Neutrino Spectra Formation in Supernovae

NASA Astrophysics Data System (ADS)

Raffelt, Georg G.

2001-11-01

The μ- and τ-neutrinos emitted from a proto-neutron star are produced by nucleonic bremsstrahlung NN-->NNνν and pair annihilation e+e--->νν, reactions that freeze out at the ``energy sphere.'' Before escaping from there to infinity, the neutrinos diffuse through the ``scattering atmosphere,'' a layer in which their main interaction is elastic scattering on nucleons νN-->Nν. If these collisions are taken to be isoenergetic, as in all numerical supernova simulations, the neutrino flux spectrum escaping to infinity depends only on the medium temperature TES and the thermally averaged optical depth τES at the energy sphere. For τES=10-50, one finds for the spectral flux temperature of the escaping neutrinos Tflux=0.5-0.6TES. Including energy exchange (nucleon recoil) in νN-->Nν can shift Tflux both up and down. ΔTflux depends on τES, on the scattering atmosphere's temperature profile, and on TES. Based on a numerical study, we find that for typical conditions, ΔTflux/Tflux is between -10% and -20% and even for extreme parameter choices does not exceed -30%. The exact value of ΔTflux/Tflux is surprisingly insensitive to the assumed value of the nucleon mass; i.e., the exact efficiency of energy transfer between neutrinos and nucleons is not important as long as it can occur at all. Therefore, calculating the νμ and ντ spectra does not seem to require a precise knowledge of the nuclear medium's dynamical structure functions.

Neutrino Observations from the Sudbury Neutrino Observatory

DOE R&D Accomplishments Database

Q. R. Ahmad, R. C. Allen, T. C. Andersen, J. D. Anglin, G. B?hler, J. C. Barton, E. W. Beier, M. Bercovitch, J. Bigu, S. Biller, R. A. Black, I. Blevis, R. J. Boardman, J. Boger, E. Bonvin, M. G. Boulay, M. G. Bowler, T. J. Bowles, S. J. Brice, M. C. Browne, T. V. Bullard, T. H. Burritt, K. Cameron, J. Cameron, Y. D. Chan, M. Chen, H. H. Chen, X. Chen, M. C. Chon, B. T. Cleveland, E. T. H. Clifford, J. H. M. Cowan, D. F. Cowen, G. A. Cox, Y. Dai, X. Dai, F. Dalnoki-Veress, W. F. Davidson, P. J. Doe, G. Doucas, M. R. Dragowsky, C. A. Duba, F. A. Duncan, J. Dunmore, E. D. Earle, S. R. Elliott, H. C. Evans, G. T. Ewan, J. Farine, H. Fergani, A. P. Ferraris, R. J. Ford, M. M. Fowler, K. Frame, E. D. Frank, W. Frati, J. V. Germani, S. Gil, A. Goldschmidt, D. R. Grant, R. L. Hahn, A. L. Hallin, E. D. Hallman, A. Hamer, A. A. Hamian, R. U. Haq, C. K. Hargrove, P. J. Harvey, R. Hazama, R. Heaton, K. M. Heeger, W. J. Heintzelman, J. Heise, R. L. Helmer, J. D. Hepburn, H. Heron, J. Hewett, A. Hime, M. Howe, J. G. Hykawy, M. C. P. Isaac, P. Jagam, N. A. Jelley, C. Jillings, G. Jonkmans, J. Karn, P. T. Keener, K. Kirch, J. R. Klein, A. B. Knox, R. J. Komar, R. Kouzes, T. Kutter, C. C. M. Kyba, J. Law, I. T. Lawson, M. Lay, H. W. Lee, K. T. Lesko, J. R. Leslie, I. Levine, W. Locke, M. M. Lowry, S. Luoma, J. Lyon, S. Majerus, H. B. Mak, A. D. Marino, N. McCauley, A. B. McDonald, D. S. McDonald, K. McFarlane, G. McGregor, W. McLatchie, R. Meijer Drees, H. Mes, C. Mifflin, G. G. Miller, G. Milton, B. A. Moffat, M. Moorhead, C. W. Nally, M. S. Neubauer, F. M. Newcomer, H. S. Ng, A. J. Noble, E. B. Norman, V. M. Novikov, M. O'Neill, C. E. Okada, R. W. Ollerhead, M. Omori, J. L. Orrell, S. M. Oser, A. W. P. Poon, T. J. Radcliffe, A. Roberge, B. C. Robertson, R. G. H. Robertson, J. K. Rowley, V. L. Rusu, E. Saettler, K. K. Schaffer, A. Schuelke, M. H. Schwendener, H. Seifert, M. Shatkay, J. J. Simpson, D. Sinclair, P. Skensved, A. R. Smith, M. W. E. Smith, N. Starinsky, T. D. Steiger, R. G. Stokstad, R. S. Storey, B. Sur, R. Tafirout, N. Tagg, N. W. Tanner, R. K. Taplin, M. Thorman, P. Thornewell, P. T. Trent, Y. I. Tserkovnyak, R. Van Berg, R. G. Van de Water, C. J. Virtue, C. E. Waltham, J.-X. Wang, D. L. Wark, N. West, J. B. Wilhelmy, J. F. Wilkerson, J. Wilson, P. Wittich, J. M. Wouters, and M. Yeh

2001-09-24

The Sudbury Neutrino Observatory (SNO) is a water imaging Cherenkov detector. Its usage of 1000 metric tons of D{sub 2}O as target allows the SNO detector to make a solar-model independent test of the neutrino oscillation hypothesis by simultaneously measuring the solar {nu}{sub e} flux and the total flux of all active neutrino species. Solar neutrinos from the decay of {sup 8}B have been detected at SNO by the charged-current (CC) interaction on the deuteron and by the elastic scattering (ES) of electrons. While the CC reaction is sensitive exclusively to {nu}{sub e}, the ES reaction also has a small sensitivity to {nu}{sub {mu}} and {nu}{sub {tau}}. In this paper, recent solar neutrino results from the SNO experiment are presented. It is demonstrated that the solar flux from {sup 8}B decay as measured from the ES reaction rate under the no-oscillation assumption is consistent with the high precision ES measurement by the Super-Kamiokande experiment. The {nu}{sub e} flux deduced from the CC reaction rate in SNO differs from the Super-Kamiokande ES results by 3.3{sigma}. This is evidence for an active neutrino component, in additional to {nu}{sub e}, in the solar neutrino flux. These results also allow the first experimental determination of the total active {sup 8}B neutrino flux from the Sun, and is found to be in good agreement with solar model predictions.

Observation of tau neutrino appearance in the CNGS beam with the OPERA experiment

NASA Astrophysics Data System (ADS)

Opera Collaboration; Agafonova, N.; Aleksandrov, A.; Anokhina, A.; Aoki, S.; Ariga, A.; Ariga, T.; Asada, T.; Bender, D.; Bertolin, A.; Bozza, C.; Brugnera, R.; Buonaura, A.; Buontempo, S.; Büttner, B.; Chernyavsky, M.; Chukanov, A.; Consiglio, L.; D'Ambrosio, N.; de Lellis, G.; de Serio, M.; Del Amo Sanchez, P.; di Crescenzo, A.; di Ferdinando, D.; di Marco, N.; Dmitrievski, S.; Dracos, M.; Duchesneau, D.; Dusini, S.; Dzhatdoev, T.; Ebert, J.; Ereditato, A.; Fini, R. A.; Fukuda, T.; Galati, G.; Garfagnini, A.; Giacomelli, G.; Goellnitz, C.; Goldberg, J.; Gornushkin, Y.; Grella, G.; Guler, M.; Gustavino, C.; Hagner, C.; Hara, T.; Hayakawa, T.; Hollnagel, A.; Hosseini, B.; Ishida, H.; Ishiguro, K.; Jakovcic, K.; Jollet, C.; Kamiscioglu, C.; Kamiscioglu, M.; Katsuragawa, T.; Kawada, J.; Kawahara, H.; Kim, J. H.; Kim, S. H.; Kitagawa, N.; Klicek, B.; Kodama, K.; Komatsu, M.; Kose, U.; Kreslo, I.; Lauria, A.; Lenkeit, J.; Ljubicic, A.; Longhin, A.; Loverre, P.; Malenica, M.; Malgin, A.; Mandrioli, G.; Matsuo, T.; Matveev, V.; Mauri, N.; Medinaceli, E.; Meregaglia, A.; Meyer, M.; Mikado, S.; Miyanishi, M.; Monacelli, P.; Montesi, M. C.; Morishima, K.; Muciaccia, M. T.; Naganawa, N.; Naka, T.; Nakamura, M.; Nakano, T.; Nakatsuka, Y.; Niwa, K.; Ogawa, S.; Okateva, N.; Olshevsky, A.; Omura, T.; Ozaki, K.; Paoloni, A.; Park, B. D.; Park, I. G.; Pasqualini, L.; Pastore, A.; Patrizii, L.; Pessard, H.; Pistillo, C.; Podgrudkov, D.; Polukhina, N.; Pozzato, M.; Pupilli, F.; Roda, M.; Roganova, T.; Rokujo, H.; Rosa, G.; Ryazhskaya, O.; Sato, O.; Schembri, A.; Shakiryanova, I.; Shchedrina, T.; Sheshukov, A.; Shibuya, H.; Shiraishi, T.; Shoziyoev, G.; Simone, S.; Sioli, M.; Sirignano, C.; Sirri, G.; Spinetti, M.; Stanco, L.; Starkov, N.; Stellacci, S. M.; Stipcevic, M.; Strolin, P.; Takahashi, S.; Tenti, M.; Terranova, F.; Tioukov, V.; Tufanli, S.; Umemoto, A.; Vilain, P.; Vladimirov, M.; Votano, L.; Vuilleumier, J. L.; Wilquet, G.; Wonsak, B.; Yoon, C. S.; Yaguchi, I.; Yoshimoto, M.; Zemskova, S.; Zghiche, A.

2014-10-01

The OPERA experiment is searching for ν _μ rArr ν _tau oscillations in appearance mode, i.e., via the direct detection of tau leptons in ν _tau charged-current interactions. The evidence of ν _μ rArr ν _tau appearance has been previously reported with three ν _tau candidate events using a sub-sample of data from the 2008-2012 runs. We report here a fourth ν _tau candidate event, with the tau decaying into a hadron, found after adding the 2012 run events without any muon in the final state to the data sample. Given the number of analyzed events and the low background, ν _μ rArr ν _tau oscillations are established with a significance of 4.2σ.

Flavour-symmetric type-II Dirac neutrino seesaw mechanism

NASA Astrophysics Data System (ADS)

Bonilla, Cesar; Lamprea, J. M.; Peinado, Eduardo; Valle, Jose W. F.

2018-04-01

We propose a Standard Model extension with underlying A4 flavour symmetry where small Dirac neutrino masses arise from a Type-II seesaw mechanism. The model predicts the "golden" flavour-dependent bottom-tau mass relation, requires an inverted neutrino mass ordering and non-maximal atmospheric mixing angle. Using the latest neutrino oscillation global fit [1] we derive restrictions on the oscillation parameters, such as a correlation between δCP and mνlightest.

Astrophysical tests for radiative decay of neutrinos and fundamental physics implications

NASA Technical Reports Server (NTRS)

Stecker, F. W.; Brown, R. W.

1981-01-01

The radiative lifetime tau for the decay of massious neutrinos was calculated using various physical models for neutrino decay. The results were then related to the astrophysical problem of the detectability of the decay photons from cosmic neutrinos. Conversely, the astrophysical data were used to place lower limits on tau. These limits are all well below predicted values. However, an observed feature at approximately 1700 A in the ultraviolet background radiation at high galactic latitudes may be from the decay of neutrinos with mass approximately 14 eV. This would require a decay rate much larger than the predictions of standard models but could be indicative of a decay rate possible in composite models or other new physics. Thus an important test for substructure in leptons and quarks or other physics beyond the standard electroweak model may have been found.

Dirac neutrinos and SN 1987A

NASA Technical Reports Server (NTRS)

Turner, Michael S.

1991-01-01

Previous work has shown that the cooling of SN 1987A excludes a Dirac-neutrino mass greater than theta(20 keV) for nu(sub e), nu(sub mu), or nu(sub tau). The emission of wrong-helicity, Dirac neutrinos from SN 1987A, is re-examined. It is concluded that the effect of a Dirac neutrino on the cooling of SN 1987A has been underestimated due to neutrino degeneracy and additional emission processes. The limit that follows from the cooling of SN 1987A is believed to be greater (probably much greater) than 10 keV. This result is significant in light of the recent evidence for a 17 keV mass eigenstate that mixes with the electron neutrino.

Overview and Status of Experimental Neutrino Physics

NASA Astrophysics Data System (ADS)

Stancu, Ion

2002-10-01

Seventy years after the existence of the neutrino has been postulated by Wolfgang Pauli, these elusive particles remain surrounded by mystery. One of the most fundamental questions about neutrinos is whether they have an identically vanishing mass, as assumed by the Standard Model, or not. Direct measurements have proven to be extremely difficult to perform, and have yielded so far only upper limits. However, if neutrino flavour oscillations do happen, this would automatically imply that at least one of the three neutrinos (the electron, muon or tau neutrino) must have a non-zero mass. The present experimental data indicate that both the solar and atmospheric neutrino deficits can be explained by the phenomenon of neutrino oscillations, while the positive signal reported by the accelerator-based LSND experiment remains to be verified by an independent measurement (MiniBooNE). This talk reviews the current status of the neutrino oscillations experiments, experiments which are quite likely to produce results with significant consequences for both the Standard Model and Cosmology.

E sub 6 leptoquarks and the solar neutrino problem

NASA Technical Reports Server (NTRS)

Roulet, Esteban

1991-01-01

The possibility that non-conventional neutrino oscillations take place in the superstring inspired E sub 6 models is considered. In this context, the influence of leptoquark mediated interactions of the neutrinos with nucleons in the resonant flavor conversion is discussed. It is shown that this effect can be significant for v sub e - v sub tau oscillations if these neutrinos have masses required in the ordinary Mikheyev-Smirnov-Wolfenstein (MSW) effect, and may lead to a solution of the solar neutrino problem even in the absence of vacuum mixings. On the other hand, this model cannot lead to a resonant behavior in the sun if the neutrinos are massless.

Right-Handed Neutrinos and the 2 TeV $W'$ Boson

DOE PAGES

Coloma, Pilar; Dobrescu, Bogdan A.; Lopez-Pavon, Jacobo

2015-12-30

The CMS e +e -jj events of invariant mass near 2 TeV are consistent with a W' boson decaying into an electron and a right-handed neutrino whose TeV-scale mass is of the Dirac type. We show that the Dirac partner of the right-handed electron-neutrino can be the right-handed tau-neutrino. Furthermore, a prediction of this model is that the sum of the τ +e +jj and τ -e -jj signal cross sections equals twice that for e +e -jj. The Standard Model neutrinos acquire Majorana masses and mixings compatible with neutrino oscillation data.

Search for third-generation scalar leptoquarks and heavy right-handed neutrinos in final states with two tau leptons and two jets in proton-proton collisions at $$ \\sqrt{s}=13 $$ TeV

DOE PAGES

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; ...

2017-07-26

A search is performed for third-generation scalar leptoquarks and heavy right-handed neutrinos in events containing one electron or muon, one hadronically decaying τ lepton, and at least two jets, using amore » $$ \\sqrt{s}=13 $$ TeV pp collision data sample corresponding to an integrated luminosity of 12.9 fb$$^{-1}$$ collected with the CMS detector at the LHC in 2016. The number of observed events is found to be in agreement with the standard model prediction. A limit is set at 95% confidence level on the product of the leptoquark pair production cross section and β$$^{2}$$, where β is the branching fraction of leptoquark decay to a τ lepton and a bottom quark. Assuming β = 1, third-generation leptoquarks with masses below 850 GeV are excluded at 95% confidence level. An additional search based on the same event topology involves heavy right-handed neutrinos, N$$_{R}$$, and right-handed W bosons, W$$_{R}$$, arising in a left-right symmetric extension of the standard model. In this search, W$$_{R}$$ bosons are assumed to decay to a tau lepton and N$$_{R}$$ followed by the decay of the N$$_{R}$$ to a tau lepton and an off-shell W$$_{R}$$ boson. Assuming the mass of the right-handed neutrino to be half of the mass of the right-handed W boson, W$$_{R}$$ boson masses below 2.9 TeV are excluded at 95% confidence level. Lastly, these results improve on the limits from previous searches for third-generation leptoquarks and heavy right-handed neutrinos with τ leptons in the final state.« less

Search for third-generation scalar leptoquarks and heavy right-handed neutrinos in final states with two tau leptons and two jets in proton-proton collisions at $$ \\sqrt{s}=13 $$ TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.

A search is performed for third-generation scalar leptoquarks and heavy right-handed neutrinos in events containing one electron or muon, one hadronically decaying τ lepton, and at least two jets, using amore » $$ \\sqrt{s}=13 $$ TeV pp collision data sample corresponding to an integrated luminosity of 12.9 fb$$^{-1}$$ collected with the CMS detector at the LHC in 2016. The number of observed events is found to be in agreement with the standard model prediction. A limit is set at 95% confidence level on the product of the leptoquark pair production cross section and β$$^{2}$$, where β is the branching fraction of leptoquark decay to a τ lepton and a bottom quark. Assuming β = 1, third-generation leptoquarks with masses below 850 GeV are excluded at 95% confidence level. An additional search based on the same event topology involves heavy right-handed neutrinos, N$$_{R}$$, and right-handed W bosons, W$$_{R}$$, arising in a left-right symmetric extension of the standard model. In this search, W$$_{R}$$ bosons are assumed to decay to a tau lepton and N$$_{R}$$ followed by the decay of the N$$_{R}$$ to a tau lepton and an off-shell W$$_{R}$$ boson. Assuming the mass of the right-handed neutrino to be half of the mass of the right-handed W boson, W$$_{R}$$ boson masses below 2.9 TeV are excluded at 95% confidence level. Lastly, these results improve on the limits from previous searches for third-generation leptoquarks and heavy right-handed neutrinos with τ leptons in the final state.« less

Sterile neutrinos and flavor ratios in IceCube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brdar, Vedran; Kopp, Joachim; Wang, Xiao-Ping, E-mail: vbrdar@uni-mainz.de, E-mail: jkopp@uni-mainz.de, E-mail: xiaowang@uni-mainz.de

2017-01-01

The flavor composition of astrophysical neutrinos observed in neutrino telescopes is a powerful discriminator between different astrophysical neutrino production mechanisms and can also teach us about the particle physics properties of neutrinos. In this paper, we investigate how the possible existence of light sterile neutrinos can affect these flavor ratios. We consider two scenarios: (i) neutrino production in conventional astrophysical sources, followed by partial oscillation into sterile states; (ii) neutrinos from dark matter decay with a primary flavor composition enhanced in tau neutrinos or sterile neutrinos. Throughout the paper, we constrain the sterile neutrino mixing parameters from a full globalmore » fit to short and long baseline data. We present our results in the form of flavor triangles and, for scenario (ii), as exclusion limits on the dark matter mass and lifetime, derived from a fit to IceCube high energy starting events and through-going muons. We argue that identifying a possible flux of neutrinos from dark matter decay may require analyzing the flavor composition as a function of neutrino energy.« less

Lepton Flavorful Fifth Force and Depth-Dependent Neutrino Matter Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wise, Mark B.; Zhang, Yue

We consider a fifth force to be an interaction that couples to matter with a strength that grows with the number of atoms. In addition to competing with the strength of gravity a fifth force can give rise to violations of the equivalence principle. Current long range constraints on the strength and range of fifth forces are very impressive. Amongst possible fifth forces are those that couple to lepton flavorful chargesmore » $$L_e-L_{\\mu}$$ or $$L_e-L_{\\tau}$$. They have the property that their range and strength are also constrained by neutrino interactions with matter. In this brief note we review the existing constraints on the allowed parameter space in gauged $$U(1)_{L_e-L_{\\mu}, L_{\\tau}}$$. We find two regions where neutrino oscillation experiments are at the frontier of probing such a new force. In particular, there is an allowed range of parameter space where neutrino matter interactions relevant for long baseline oscillation experiments depend on the depth of the neutrino beam below the surface of the earth.« less

Search for Point Sources of High Energy Neutrinos with Final Data from AMANDA-II

DOE Office of Scientific and Technical Information (OSTI.GOV)

IceCube Collaboration; Klein, Spencer

2009-03-06

We present a search for point sources of high energy neutrinos using 3.8 years of data recorded by AMANDA-II during 2000-2006. After reconstructing muon tracks and applying selection criteria designed to optimally retain neutrino-induced events originating in the Northern Sky, we arrive at a sample of 6595 candidate events, predominantly from atmospheric neutrinos with primary energy 100 GeV to 8 TeV. Our search of this sample reveals no indications of a neutrino point source. We place the most stringent limits to date on E{sup -2} neutrino fluxes from points in the Northern Sky, with an average upper limit of E{supmore » 2}{Phi}{sub {nu}{sub {mu}}+{nu}{sub {tau}}} {le} 5.2 x 10{sup -11} TeV cm{sup -2} s{sup -1} on the sum of {nu}{sub {mu}} and {nu}{sub {tau}} fluxes, assumed equal, over the energy range from 1.9 TeV to 2.5 PeV.« less

Search for point sources of high energy neutrinos with final data from AMANDA-II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abbasi, R.; Andeen, K.; Baker, M.

2009-03-15

We present a search for point sources of high energy neutrinos using 3.8 yr of data recorded by AMANDA-II during 2000-2006. After reconstructing muon tracks and applying selection criteria designed to optimally retain neutrino-induced events originating in the northern sky, we arrive at a sample of 6595 candidate events, predominantly from atmospheric neutrinos with primary energy 100 GeV to 8 TeV. Our search of this sample reveals no indications of a neutrino point source. We place the most stringent limits to date on E{sup -2} neutrino fluxes from points in the northern sky, with an average upper limit of E{supmore » 2}{phi}{sub {nu}{sub {mu}}}{sub +{nu}{sub {tau}}}{<=}5.2x10{sup -11} TeV cm{sup -2} s{sup -1} on the sum of {nu}{sub {mu}} and {nu}{sub {tau}} fluxes, assumed equal, over the energy range from 1.9 TeV to 2.5 PeV.« less

Heavy Right-Handed Neutrino Dark Matter and PeV Neutrinos at IceCube

NASA Technical Reports Server (NTRS)

Bhupal Dev, P. S.; Kazanas, D.; Mohapatra, R. N.; Teplitz, V. L.; Zhang, Yongchao

2016-01-01

We discuss a simple non-supersymmetric model based on the electroweak gauge group SU(2) (sub L) times SU(2) prime times U(1) (Sub B-L) where the lightest of the right-handed neutrinos, which are part of the leptonic doublet of SU(2) prime, play the role of a long-lived unstable dark matter with mass in the multi-Peta-electronvolt range. We use a resonant s-channel annihilation to obtain the correct thermal relic density and relax the unitarity bound on dark matter mass. In this model, there exists a 3-body dark matter decay mode producing tau leptons and neutrinos, which could be the source for the Peta-electronvolt cascade events observed in the IceCube experiment. The model can be tested with more precise flavor information of the highest-energy neutrino events in future data.

Search for W' decaying to tau lepton and neutrino in proton-proton collisions at $$\\sqrt{s}$$ = 8 TeV

DOE PAGES

Khachatryan, Vardan

2016-02-03

We found that the first search for a heavy charged vector boson in the final state with a tau lepton and a neutrino is reported, using 19.7 fb -1 of LHC data at √s = 8 TeV. A signal would appear as an excess of events in kinematic regions where the standard model background is low. No excess is observed. Limits are set on a model in which the W' decays preferentially to fermions of the third generation. Our results substantially extend previous constraints on this model. Masses below 2.0 to 2.7 TeV are excluded, depending on the model parameters.more » In addition, the existence of a W' boson with universal fermion couplings is excluded at 95% confidence level, for W' masses below 2.7 TeV.« less

Petit-exposure at neutrino beamline (PEANUT)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Niwa, K.; /Nagoya U.

2005-08-01

The advantages of using nuclear emulsion as a particle detector are well known. The high resolution of emulsion has made it a medium of choice for a number of applications where the required spatial and angular resolution are paramount and its limitations due to the lack of timing information are less important. Emulsions are commonly used as cosmic ray detectors and have found applications in high energy experiments for detecting short lived particles such as charm, beauty and tau. The addition of electronic detectors to emulsion experiments solved the problem of the lack of timing information in the emulsion, butmore » it was the development of automatic scanning machines that revolutionized the use of these hybrid detectors, making them capable of performing even in high rate environments. Most recently, The DONuT experiment (FNAL-E872), used a hybrid emulsion spectrometer to make the first direct observation of tau neutrino interactions [1]. The CNGS facility is being constructed to deliver a {nu}{sub {mu}} beam from the CERN SPS to the Gran Sasso Laboratory. Since it is believed that {nu}{sub {mu}} {leftrightarrow} {nu}{sub {tau}} oscillations explain the observed atmospheric {nu}{sub {mu}} deficit, the CNGS beam, coupled with a detector capable of observing {tau} appearance is an important experiment in the context of the world wide effort to determine the neutrino mass mixing matrix. The OPERA detector has been optimized to detect a significant sample of {nu}{sub {tau}} interactions by the subsequent observation of {tau} production and decay [2]. The OPERA target is a massive emulsion detector made in a sandwich structure of lead plates and layers of nuclear emulsion. For historical reasons this arrangement has been called an Emulsion Cloud Chamber or ECC. The ECC concept, which has many advantages over the use of bulk emulsion, has been used in the DONuT experiment. The ECC detector is capable of measuring all of the tracks, not due to nuclear fragments

Heavy right-handed neutrino dark matter and PeV neutrinos at IceCube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dev, P.S. Bhupal; Kazanas, D.; Mohapatra, R.N.

2016-08-17

We discuss a simple non-supersymmetric model based on the electroweak gauge group SU(2){sub L}×SU(2){sup ′}×U(1){sub B−L} where the lightest of the right-handed neutrinos, which are part of the leptonic doublet of SU(2){sup ′}, play the role of a long-lived unstable dark matter with mass in the multi-PeV range. We use a resonant s-channel annihilation to obtain the correct thermal relic density and relax the unitarity bound on dark matter mass. In this model, there exists a 3-body dark matter decay mode producing tau leptons and neutrinos, which could be the source for the PeV cascade events observed in the IceCubemore » experiment. The model can be tested with more precise flavor information of the highest-energy neutrino events in future data.« less

Nuclear Emulsion Analysis Methods of Locating Neutrino Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erickson, Carolyn Lee

2006-12-01

The Fermilab experiment 872 (DONUT) was the first to directly observe tau neutrinos in the charged current interactionV more » $$\\tau$$+N →$$\\tau$$ +X. The observation was made using a hybrid emulsion-spectrometer detector to identify the signature kink or trident decay of the tau particle. Although nuclear emulsion has the benefit of sub-micron resolution, its use incorporates difficulties such as significant distortions and a high density of data resulting from its continuously active state. Finding events and achieving sub-micron resolution in emulsion requires a multi-pronged strategy of tracking and vertex location to deal with these inherent difficulties. By applying the methods developed in this thesis, event location efficiency can be improved from a value of 58% to 87%.« less

The Potential of Spaced-based High-Energy Neutrino Measurements via the Airshower Cherenkov Signal

NASA Technical Reports Server (NTRS)

Krizmanic, John F.; Mitchell, John W.

2011-01-01

Future space-based experiments, such as (Orbiting Wide-angle Light Collectors (OWL) and JEM-EUSO, view large atmospheric and terrestrial neutrino targets. With energy thresholds slightly above 10(exp 19) eV for observing airshowers via air fluorescence, the potential for observing the cosmogenic neutrino flux associated with the GZK effect is limited. However, the forward Cherenkov signal associated with the airshower can be observed at much lower energies. A simulation was developed to determine the Cherenkov signal strength and spatial extent at low-Earth orbit for upward-moving airshowers. A model of tau neutrino interactions in the Earth was employed to determine the event rate of interactions that yielded a tau lepton which would induce an upward-moving airshower observable by a space-based instrument. The effect of neutrino attenuation by the Earth forces the viewing of the Earth's limb to observe the vT-induced Cherenkov airshower signal at above the OWL Cherenkov energy threshold of approximately 10(exp 16.5) eV for limb-viewed events. Furthermore, the neutrino attenuation limits the effective terrestrial neutrino target area to approximately 3 x 10(exp 5) square km at 10(exp 17) eV, for an orbit of 1000 km and an instrumental full Field-of-View of 45 deg. This translates into an observable cosmogenic neutrino event rate of approx. l/year based upon two different models of the cosmogenic neutrino flux, assuming neutrino oscillations and a 10% duty cycle for observation.

Astrophysical neutrinos flavored with beyond the Standard Model physics

NASA Astrophysics Data System (ADS)

Rasmussen, Rasmus W.; Lechner, Lukas; Ackermann, Markus; Kowalski, Marek; Winter, Walter

2017-10-01

We systematically study the allowed parameter space for the flavor composition of astrophysical neutrinos measured at Earth, including beyond the Standard Model theories at production, during propagation, and at detection. One motivation is to illustrate the discrimination power of the next-generation neutrino telescopes such as IceCube-Gen2. We identify several examples that lead to potential deviations from the standard neutrino mixing expectation such as significant sterile neutrino production at the source, effective operators modifying the neutrino propagation at high energies, dark matter interactions in neutrino propagation, or nonstandard interactions in Earth matter. IceCube-Gen2 can exclude about 90% of the allowed parameter space in these cases, and hence will allow us to efficiently test and discriminate between models. More detailed information can be obtained from additional observables such as the energy dependence of the effect, fraction of electron antineutrinos at the Glashow resonance, or number of tau neutrino events.

Search for W‧ decaying to tau lepton and neutrino in proton-proton collisions at √{ s} = 8 TeV

NASA Astrophysics Data System (ADS)

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Knünz, V.; König, A.; Krammer, M.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Strauss, J.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; Cornelis, T.; de Wolf, E. A.; Janssen, X.; Knutsson, A.; Lauwers, J.; Luyckx, S.; Ochesanu, S.; Rougny, R.; van de Klundert, M.; van Haevermaet, H.; van Mechelen, P.; van Remortel, N.; van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; Daci, N.; de Bruyn, I.; Deroover, K.; Heracleous, N.; Keaveney, J.; Lowette, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; van Doninck, W.; van Mulders, P.; van Onsem, G. P.; van Parijs, I.; Barria, P.; Caillol, C.; Clerbaux, B.; de Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Gay, A. P. R.; Grebenyuk, A.; Lenzi, T.; Léonard, A.; Maerschalk, T.; Marinov, A.; Perniè, L.; Randle-Conde, A.; Reis, T.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Yonamine, R.; Zenoni, F.; Zhang, F.; Beernaert, K.; Benucci, L.; Cimmino, A.; Crucy, S.; Dobur, D.; Fagot, A.; Garcia, G.; Gul, M.; McCartin, J.; Ocampo Rios, A. A.; Poyraz, D.; Ryckbosch, D.; Salva, S.; Sigamani, M.; Strobbe, N.; Tytgat, M.; van Driessche, W.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Beluffi, C.; Bondu, O.; Brochet, S.; Bruno, G.; Castello, R.; Caudron, A.; Ceard, L.; da Silveira, G. G.; Delaere, C.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Jafari, A.; Jez, P.; Komm, M.; Lemaitre, V.; Mertens, A.; Nuttens, C.; Perrini, L.; Pin, A.; Piotrzkowski, K.; Popov, A.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Beliy, N.; Hammad, G. H.; Aldá Júnior, W. L.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Hensel, C.; Mora Herrera, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; da Costa, E. M.; de Jesus Damiao, D.; de Oliveira Martins, C.; Fonseca de Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Prado da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; de Souza Santos, A.; Dogra, S.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Genchev, V.; Hadjiiska, R.; Iaydjiev, P.; Piperov, S.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Cheng, T.; Du, R.; Jiang, C. H.; Plestina, R.; Romeo, F.; Shaheen, S. M.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Asawatangtrakuldee, C.; Ban, Y.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Zou, W.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; Gomez Moreno, B.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Polic, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Kadija, K.; Luetic, J.; Micanovic, S.; Sudic, L.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Bodlak, M.; Finger, M.; Finger, M.; Assran, Y.; Elgammal, S.; Mahmoud, M. A.; Calpas, B.; Kadastik, M.; Murumaa, M.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Locci, E.; Machet, M.; Malcles, J.; Rander, J.; Rosowsky, A.; Titov, M.; Zghiche, A.; Antropov, I.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Chapon, E.; Charlot, C.; Dahms, T.; Davignon, O.; Filipovic, N.; Florent, A.; Granier de Cassagnac, R.; Lisniak, S.; Mastrolorenzo, L.; Miné, P.; Naranjo, I. N.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Regnard, S.; Salerno, R.; Sauvan, J. B.; Sirois, Y.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Agram, J.-L.; Andrea, J.; Aubin, A.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Goetzmann, C.; Le Bihan, A.-C.; Merlin, J. A.; Skovpen, K.; van Hove, P.; Gadrat, S.; Beauceron, S.; Bernet, C.; Boudoul, G.; Bouvier, E.; Carrillo Montoya, C. A.; Chasserat, J.; Chierici, R.; Contardo, D.; Courbon, B.; Depasse, P.; El Mamouni, H.; Fan, J.; Fay, J.; Gascon, S.; Gouzevitch, M.; Ille, B.; Lagarde, F.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Ruiz Alvarez, J. D.; Sabes, D.; Sgandurra, L.; Sordini, V.; Vander Donckt, M.; Verdier, P.; Viret, S.; Xiao, H.; Toriashvili, T.; Tsamalaidze, Z.; Autermann, C.; Beranek, S.; Edelhoff, M.; Feld, L.; Heister, A.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Ostapchuk, A.; Preuten, M.; Raupach, F.; Schael, S.; Schulte, J. F.; Verlage, T.; Weber, H.; Wittmer, B.; Zhukov, V.; Ata, M.; Brodski, M.; Dietz-Laursonn, E.; Duchardt, D.; Edelhäuser, L.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Klingebiel, D.; Knochel, A.; Knutzen, S.; Kreuzer, P.; Merschmeyer, M.; Meyer, A.; Millet, P.; Olschewski, M.; Padeken, K.; Papacz, P.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Sonnenschein, L.; Teyssier, D.; Thüer, S.; Cherepanov, V.; Erdogan, Y.; Flügge, G.; Geenen, H.; Geisler, M.; Hoehle, F.; Kargoll, B.; Kress, T.; Kuessel, Y.; Künsken, A.; Lingemann, J.; Nehrkorn, A.; Nowack, A.; Nugent, I. M.; Pistone, C.; Pooth, O.; Stahl, A.; Aldaya Martin, M.; Asin, I.; Bartosik, N.; Behnke, O.; Behrens, U.; Bell, A. J.; Borras, K.; Burgmeier, A.; Cakir, A.; Calligaris, L.; Campbell, A.; Choudhury, S.; Costanza, F.; Diez Pardos, C.; Dolinska, G.; Dooling, S.; Dorland, T.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Flucke, G.; Gallo, E.; Garay Garcia, J.; Geiser, A.; Gizhko, A.; Gunnellini, P.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Karacheban, O.; Kasemann, M.; Katsas, P.; Kieseler, J.; Kleinwort, C.; Korol, I.; Lange, W.; Leonard, J.; Lipka, K.; Lobanov, A.; Lohmann, W.; Mankel, R.; Marfin, I.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Naumann-Emme, S.; Nayak, A.; Ntomari, E.; Perrey, H.; Pitzl, D.; Placakyte, R.; Raspereza, A.; Roland, B.; Sahin, M. Ö.; Saxena, P.; Schoerner-Sadenius, T.; Schröder, M.; Seitz, C.; Spannagel, S.; Trippkewitz, K. D.; Walsh, R.; Wissing, C.; Blobel, V.; Centis Vignali, M.; Draeger, A. R.; Erfle, J.; Garutti, E.; Goebel, K.; Gonzalez, D.; Görner, M.; Haller, J.; Hoffmann, M.; Höing, R. S.; Junkes, A.; Klanner, R.; Kogler, R.; Lapsien, T.; Lenz, T.; Marchesini, I.; Marconi, D.; Nowatschin, D.; Ott, J.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Pietsch, N.; Poehlsen, J.; Rathjens, D.; Sander, C.; Schettler, H.; Schleper, P.; Schlieckau, E.; Schmidt, A.; Schwandt, J.; Seidel, M.; Sola, V.; Stadie, H.; Steinbrück, G.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Akbiyik, M.; Barth, C.; Baus, C.; Berger, J.; Böser, C.; Butz, E.; Chwalek, T.; Colombo, F.; de Boer, W.; Descroix, A.; Dierlamm, A.; Fink, S.; Frensch, F.; Giffels, M.; Gilbert, A.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Kassel, F.; Katkov, I.; Kornmayer, A.; Lobelle Pardo, P.; Maier, B.; Mildner, H.; Mozer, M. U.; Müller, T.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Röcker, S.; Roscher, F.; Simonis, H. J.; Stober, F. M.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weber, M.; Weiler, T.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Psallidas, A.; Topsis-Giotis, I.; Agapitos, A.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Tziaferi, E.; Evangelou, I.; Flouris, G.; Foudas, C.; Kokkas, P.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Strologas, J.; Bencze, G.; Hajdu, C.; Hazi, A.; Hidas, P.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Molnar, J.; Szillasi, Z.; Bartók, M.; Makovec, A.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Mal, P.; Mandal, K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chawla, R.; Gupta, R.; Bhawandeep, U.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Mehta, A.; Mittal, M.; Singh, J. B.; Walia, G.; Kumar, Ashok; Kumar, Arun; Bhardwaj, A.; Choudhary, B. C.; Garg, R. B.; Kumar, A.; Malhotra, S.; Naimuddin, M.; Nishu, N.; Ranjan, K.; Sharma, R.; Sharma, V.; Banerjee, S.; Bhattacharya, S.; Chatterjee, K.; Dey, S.; Dutta, S.; Jain, Sa.; Majumdar, N.; Modak, A.; Mondal, K.; Mukherjee, S.; Mukhopadhyay, S.; Roy, A.; Roy, D.; Roy Chowdhury, S.; Sarkar, S.; Sharan, M.; Abdulsalam, A.; Chudasama, R.; Dutta, D.; Jha, V.; Kumar, V.; Mohanty, A. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Banerjee, S.; Bhowmik, S.; Chatterjee, R. M.; Dewanjee, R. K.; Dugad, S.; Ganguly, S.; Ghosh, S.; Guchait, M.; Gurtu, A.; Kole, G.; Kumar, S.; Mahakud, B.; Maity, M.; Majumder, G.; Mazumdar, K.; Mitra, S.; Mohanty, G. B.; Parida, B.; Sarkar, T.; Sudhakar, K.; Sur, N.; Sutar, B.; Wickramage, N.; Chauhan, S.; Dube, S.; Sharma, S.; Bakhshiansohi, H.; Behnamian, H.; Etesami, S. M.; Fahim, A.; Goldouzian, R.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Chhibra, S. S.; Colaleo, A.; Creanza, D.; Cristella, L.; de Filippis, N.; de Palma, M.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Benvenuti, A. C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Travaglini, R.; Cappello, G.; Chiorboli, M.; Costa, S.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Gonzi, S.; Gori, V.; Lenzi, P.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Tropiano, A.; Viliani, L.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Calvelli, V.; Ferro, F.; Lo Vetere, M.; Monge, M. R.; Robutti, E.; Tosi, S.; Brianza, L.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Gerosa, R.; Ghezzi, A.; Govoni, P.; Malvezzi, S.; Manzoni, R. A.; Marzocchi, B.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Ragazzi, S.; Redaelli, N.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; di Guida, S.; Esposito, M.; Fabozzi, F.; Iorio, A. O. M.; Lanza, G.; Lista, L.; Meola, S.; Merola, M.; Paolucci, P.; Sciacca, C.; Thyssen, F.; Azzi, P.; Bacchetta, N.; Benato, L.; Bisello, D.; Boletti, A.; Branca, A.; Carlin, R.; Checchia, P.; Dall'Osso, M.; Dorigo, T.; Gasparini, F.; Gasparini, U.; Gozzelino, A.; Kanishchev, K.; Lacaprara, S.; Margoni, M.; Meneguzzo, A. T.; Montecassiano, F.; Passaseo, M.; Pazzini, J.; Pozzobon, N.; Ronchese, P.; Simonetto, F.; Torassa, E.; Tosi, M.; Zanetti, M.; Zotto, P.; Zucchetta, A.; Zumerle, G.; Braghieri, A.; Magnani, A.; Montagna, P.; Ratti, S. P.; Re, V.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Alunni Solestizi, L.; Biasini, M.; Bilei, G. M.; Ciangottini, D.; Fanò, L.; Lariccia, P.; Mantovani, G.; Menichelli, M.; Saha, A.; Santocchia, A.; Spiezia, A.; Androsov, K.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Broccolo, G.; Castaldi, R.; Ciocci, M. A.; Dell'Orso, R.; Donato, S.; Fedi, G.; Foà, L.; Giassi, A.; Grippo, M. T.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Savoy-Navarro, A.; Serban, A. T.; Spagnolo, P.; Squillacioti, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; D'Imperio, G.; Del Re, D.; Diemoz, M.; Gelli, S.; Jorda, C.; Longo, E.; Margaroli, F.; Meridiani, P.; Micheli, F.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Traczyk, P.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bellan, R.; Biino, C.; Cartiglia, N.; Costa, M.; Covarelli, R.; de Remigis, P.; Degano, A.; Demaria, N.; Finco, L.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Musich, M.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. 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A.; Kubik, A.; Mucia, N.; Odell, N.; Pollack, B.; Pozdnyakov, A.; Schmitt, M.; Stoynev, S.; Sung, K.; Trovato, M.; Velasco, M.; Won, S.; Brinkerhoff, A.; Dev, N.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Lynch, S.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Pearson, T.; Planer, M.; Reinsvold, A.; Ruchti, R.; Smith, G.; Taroni, S.; Valls, N.; Wayne, M.; Wolf, M.; Woodard, A.; Antonelli, L.; Brinson, J.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Hart, A.; Hill, C.; Hughes, R.; Kotov, K.; Ling, T. Y.; Liu, B.; Luo, W.; Puigh, D.; Rodenburg, M.; Winer, B. L.; Wulsin, H. W.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Koay, S. A.; Lujan, P.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Palmer, C.; Piroué, P.; Quan, X.; Saka, H.; Stickland, D.; Tully, C.; Werner, J. S.; Zuranski, A.; Malik, S.; Barnes, V. E.; Benedetti, D.; Bortoletto, D.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, K.; Kress, M.; Miller, D. H.; Neumeister, N.; Primavera, F.; Radburn-Smith, B. C.; Shi, X.; Shipsey, I.; Silvers, D.; Sun, J.; Svyatkovskiy, A.; Wang, F.; Xie, W.; Xu, L.; Zablocki, J.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Redjimi, R.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Betchart, B.; Bodek, A.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Goldenzweig, P.; Han, J.; Harel, A.; Hindrichs, O.; Khukhunaishvili, A.; Petrillo, G.; Verzetti, M.; Demortier, L.; Arora, S.; Barker, A.; Chou, J. P.; Contreras-Campana, C.; Contreras-Campana, E.; Duggan, D.; Ferencek, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Lath, A.; Panwalkar, S.; Park, M.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Foerster, M.; Riley, G.; Rose, K.; Spanier, S.; York, A.; Bouhali, O.; Castaneda Hernandez, A.; Dalchenko, M.; de Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Flanagan, W.; Gilmore, J.; Kamon, T.; Krutelyov, V.; Montalvo, R.; Mueller, R.; Osipenkov, I.; Pakhotin, Y.; Patel, R.; Perloff, A.; Roe, J.; Rose, A.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Cowden, C.; Damgov, J.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Undleeb, S.; Volobouev, I.; Appelt, E.; Delannoy, A. G.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Mao, Y.; Melo, A.; Sheldon, P.; Snook, B.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Boutle, S.; Cox, B.; Francis, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Lin, C.; Neu, C.; Wolfe, E.; Wood, J.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Kottachchi Kankanamge Don, C.; Lamichhane, P.; Sturdy, J.; Belknap, D. A.; Carlsmith, D.; Cepeda, M.; Christian, A.; Dasu, S.; Dodd, L.; Duric, S.; Friis, E.; Gomber, B.; Hall-Wilton, R.; Herndon, M.; Hervé, A.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Mohapatra, A.; Ojalvo, I.; Perry, T.; Pierro, G. A.; Polese, G.; Ross, I.; Ruggles, T.; Sarangi, T.; Savin, A.; Sharma, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.; Cms Collaboration

2016-04-01

The first search for a heavy charged vector boson in the final state with a tau lepton and a neutrino is reported, using 19.7 fb-1 of LHC data at √{ s} = 8 TeV. A signal would appear as an excess of events with high transverse mass, where the standard model background is low. No excess is observed. Limits are set on a model in which the W‧ decays preferentially to fermions of the third generation. These results substantially extend previous constraints on this model. Masses below 2.0 to 2.7 TeV are excluded, depending on the model parameters. In addition, the existence of a W‧ boson with universal fermion couplings is excluded at 95% confidence level, for W‧ masses below 2.7 TeV. For further reinterpretation a model-independent limit on potential signals for various transverse mass thresholds is also presented.

Search for sterile neutrino mixing in the νμ → ντ appearance channel with the OPERA detector

NASA Astrophysics Data System (ADS)

Mauri, N.

2016-11-01

The OPERA experiment has observed muon neutrino to tau neutrino oscillations in the atmospheric sector in appearance mode. Five ντ candidate events have been detected, a number consistent with the expectation from the "standard" 3ν framework. Based on this result new limits on the mixing parameters of a massive sterile neutrino have been set. The analysis is performed in the 3+1 neutrino model.

Neutrino trident production: a powerful probe of new physics with neutrino beams.

PubMed

Altmannshofer, Wolfgang; Gori, Stefania; Pospelov, Maxim; Yavin, Itay

2014-08-29

The production of a μ+ μ- pair from the scattering of a muon neutrino off the Coulomb field of a nucleus, known as neutrino trident production, is a subweak process that has been observed in only a couple of experiments. As such, we show that it constitutes an exquisitely sensitive probe in the search for new neutral currents among leptons, putting the strongest constraints on well-motivated and well-hidden extensions of the standard model gauge group, including the one coupled to the difference of the lepton number between the muon and tau flavor, Lμ-Lτ. The new gauge boson Z', increases the rate of neutrino trident production by inducing additional (μγαμ)(νγ(α)ν) interactions, which interfere constructively with the standard model contribution. Existing experimental results put significant restrictions on the parameter space of any model coupled to muon number Lμ, and disfavor a putative resolution to the muon g-2 discrepancy via the loop of Z' for any mass mZ'≳400  MeV. The reach to the models' parameter space can be widened with future searches of the trident production at high-intensity neutrino facilities such as the LBNE.

An Algorithm for the Reconstruction of Neutrino-induced Showers in the ANTARES Neutrino Telescope

NASA Astrophysics Data System (ADS)

Albert, A.; André, M.; Anghinolfi, M.; Anton, G.; Ardid, M.; Aubert, J.-J.; Avgitas, T.; Baret, B.; Barrios-Martí, J.; Basa, S.; Belhorma, B.; Bertin, V.; Biagi, S.; Bormuth, R.; Bourret, S.; Bouwhuis, M. C.; Brânzaş, H.; Bruijn, R.; Brunner, J.; Busto, J.; Capone, A.; Caramete, L.; Carr, J.; Celli, S.; Cherkaoui El Moursli, R.; Chiarusi, T.; Circella, M.; Coelho, J. A. B.; Coleiro, A.; Coniglione, R.; Costantini, H.; Coyle, P.; Creusot, A.; Díaz, A. F.; Deschamps, A.; De Bonis, G.; Distefano, C.; Di Palma, I.; Domi, A.; Donzaud, C.; Dornic, D.; Drouhin, D.; Eberl, T.; El Bojaddaini, I.; El Khayati, N.; Elsässer, D.; Enzenhöfer, A.; Ettahiri, A.; Fassi, F.; Felis, I.; Fusco, L. A.; Gay, P.; Giordano, V.; Glotin, H.; Grégoire, T.; Ruiz, R. Gracia; Graf, K.; Hallmann, S.; van Haren, H.; Heijboer, A. J.; Hello, Y.; Hernández-Rey, J. J.; Hößl, J.; Hofestädt, J.; Hugon, C.; Illuminati, G.; James, C. W.; de Jong, M.; Jongen, M.; Kadler, M.; Kalekin, O.; Katz, U.; Kießling, D.; Kouchner, A.; Kreter, M.; Kreykenbohm, I.; Kulikovskiy, V.; Lachaud, C.; Lahmann, R.; Lefèvre, D.; Leonora, E.; Lotze, M.; Loucatos, S.; Marcelin, M.; Margiotta, A.; Marinelli, A.; Martínez-Mora, J. A.; Mele, R.; Melis, K.; Michael, T.; Migliozzi, P.; Moussa, A.; Navas, S.; Nezri, E.; Organokov, M.; Păvălaş, G. E.; Pellegrino, C.; Perrina, C.; Piattelli, P.; Popa, V.; Pradier, T.; Quinn, L.; Racca, C.; Riccobene, G.; Sánchez-Losa, A.; Saldaña, M.; Salvadori, I.; Samtleben, D. F. E.; Sanguineti, M.; Sapienza, P.; Schüssler, F.; Sieger, C.; Spurio, M.; Stolarczyk, Th.; Taiuti, M.; Tayalati, Y.; Trovato, A.; Turpin, D.; Tönnis, C.; Vallage, B.; Van Elewyck, V.; Versari, F.; Vivolo, D.; Vizzoca, A.; Wilms, J.; Zornoza, J. D.; Zúñiga, J.

2017-12-01

Muons created by {ν }μ charged current (CC) interactions in the water surrounding the ANTARES neutrino telescope have been almost exclusively used so far in searches for cosmic neutrino sources. Due to their long range, highly energetic muons inducing Cherenkov radiation in the water are reconstructed with dedicated algorithms that allow for the determination of the parent neutrino direction with a median angular resolution of about 0.°4 for an {E}-2 neutrino spectrum. In this paper, an algorithm optimized for accurate reconstruction of energy and direction of shower events in the ANTARES detector is presented. Hadronic showers of electrically charged particles are produced by the disintegration of the nucleus both in CC and neutral current interactions of neutrinos in water. In addition, electromagnetic showers result from the CC interactions of electron neutrinos while the decay of a tau lepton produced in {ν }τ CC interactions will, in most cases, lead to either a hadronic or an electromagnetic shower. A shower can be approximated as a point source of photons. With the presented method, the shower position is reconstructed with a precision of about 1 m; the neutrino direction is reconstructed with a median angular resolution between 2° and 3° in the energy range of 1-1000 TeV. In this energy interval, the uncertainty on the reconstructed neutrino energy is about 5%-10%. The increase in the detector sensitivity due to the use of additional information from shower events in the searches for a cosmic neutrino flux is also presented.

Limits on muon-neutrino to tau-neutrino oscillations induced by a sterile neutrino state obtained by OPERA at the CNGS beam

NASA Astrophysics Data System (ADS)

Agafonova, N.; Aleksandrov, A.; Anokhina, A.; Aoki, S.; Ariga, A.; Ariga, T.; Bender, D.; Bertolin, A.; Bodnarchuk, I.; Bozza, C.; Brugnera, R.; Buonaura, A.; Buontempo, S.; Büttner, B.; Chernyavsky, M.; Chukanov, A.; Consiglio, L.; D'Ambrosio, N.; De Lellis, G.; De Serio, M.; Del Amo Sanchez, P.; Di Crescenzo, A.; Di Ferdinando, D.; Di Marco, N.; Dmitrievski, S.; Dracos, M.; Duchesneau, D.; Dusini, S.; Dzhatdoev, T.; Ebert, J.; Ereditato, A.; Fini, R. A.; Fukuda, T.; Galati, G.; Garfagnini, A.; Goldberg, J.; Gornushkin, Y.; Grella, G.; Guler, A. M.; Gustavino, C.; Hagner, C.; Hara, T.; Hollnagel, A.; Hosseini, B.; Ishiguro, K.; Jakovcic, K.; Jollet, C.; Kamiscioglu, C.; Kamiscioglu, M.; Kim, J. H.; Kim, S. H.; Kitagawa, N.; Klicek, B.; Kodama, K.; Komatsu, M.; Kose, U.; Kreslo, I.; Lauria, A.; Ljubicic, A.; Longhin, A.; Malgin, A.; Malenica, M.; Mandrioli, G.; Matsuo, T.; Matveev, V.; Mauri, N.; Medinaceli, E.; Meregaglia, A.; Mikado, S.; Monacelli, P.; Montesi, M. C.; Morishima, K.; Muciaccia, M. T.; Naganawa, N.; Naka, T.; Nakamura, M.; Nakano, T.; Nakatsuka, Y.; Niwa, K.; Ogawa, S.; Omura, T.; Ozaki, K.; Paoloni, A.; Paparella, L.; Park, B. D.; Park, I. G.; Pasqualini, L.; Pastore, A.; Patrizii, L.; Pessard, H.; Podgrudkov, D.; Polukhina, N.; Pozzato, M.; Pupilli, F.; Roda, M.; Roganova, T.; Rokujo, H.; Rosa, G.; Ryazhskaya, O.; Sato, O.; Schembri, A.; Shakirianova, I.; Shchedrina, T.; Sheshukov, A.; Shibuya, H.; Shiraishi, T.; Shoziyoev, G.; Simone, S.; Sioli, M.; Sirignano, C.; Sirri, G.; Spinetti, M.; Stanco, L.; Starkov, N.; Stellacci, S. M.; Stipcevic, M.; Strolin, P.; Takahashi, S.; Tenti, M.; Terranova, F.; Tioukov, V.; Tufanli, S.; Vilain, P.; Vladymyrov, M.; Votano, L.; Vuilleumier, J. L.; Wilquet, G.; Wonsak, B.; Yoon, C. S.; Zemskova, S.

2015-06-01

The OPERA experiment, exposed to the CERN to Gran Sasso ν μ beam, collected data from 2008 to 2012. Four oscillated ν τ Charged Current interaction candidates have been detected in appearance mode, which are consistent with ν μ → ν τ oscillations at the atmospheric Δ m 2 within the "standard" three-neutrino framework. In this paper, the OPERA ν τ appearance results are used to derive limits on the mixing parameters of a massive sterile neutrino.

Searches for ultra-high energy neutrinos at the Pierre Auger observatory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alvarez-Muñiz, Jaime; Observatorio Pierre Auger, Av. San Martín Norte 304, 5613 Malargüe

2015-07-15

Neutrinos in the sub-EeV energy range and above can be detected and identified with the Surface Detector array of the Pierre Auger Observatory. The identification can be efficiently done for neutrinos of all flavours interacting in the atmosphere, typically above 60° (downward-going), as well as for “Earth-skimming” neutrino interactions in the case of tau neutrinos (upward-going). Three sets of identification criteria were designed to search for downward-going neutrinos in the zenith angle bins 60° − 75° and 75° − 90° as well as for upward-going neutrinos. The three searches have been recently combined, providing, in the absence of candidates inmore » data from 1 January 04 until 31 December 12, a stringent limit to the diffuse flux of ultra-high energy neutrinos.« less

The Detection Of Neutrino Interactions In The OPERA Experiment: An Update

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patrizii, Laura

2009-12-17

OPERA is a long baseline neutrino oscillation experiment built to provide the final and unambiguous proof of the neutrino oscillation hypothesis in the atmospheric sector by observing {nu}{sub {tau}} emerging from the CNGS {nu}{sub {mu}} beam. The detector is a hybrid apparatus installed in the Hall C of the underground Gran Sasso National Laboratory in Italy. Runs with CNGS neutrinos were successfully carried out in 2007 and 2008. In this paper the detector and the analysis strategy are briefly described and the status of the analysis of the 2008 run events is discussed.

NOY: a neutrino observatory network project based on stand alone air shower detector arrays

NASA Astrophysics Data System (ADS)

Montanet, F.; Lebrun, D.; Chauvin, J.; Lagorio, E.; Stassi, P.

2011-09-01

We have developed a self powered stand alone particle detector array dedicated to the observation of horizontal tau air showers induced by high energy neutrinos interacting in mountain rock. Air shower particle detection reaches a 100% duty cycle and is practically free of background when compared to Cherenkov light or radio techniques. It is thus better suited for rare neutrino event search. An appropriate mountain to valley topological configuration has been identified and the first array will be deployed on an inclined slope at an elevation of 1500 m facing Southern Alps near the city of Grenoble (France). A full simulation has been performed. A neutrino energy dependent mountain tomography chart is obtained using a neutrino and tau propagation code together with a detailed cartography and elevation map of the region. The array acceptance is then evaluated between 1 PeV and 100 EeV by simulating decaying tau air showers across the valley. The effective detection surface is determined by the shower lateral extension at array location and is hence much larger than the array geometrical area. The array exposure will be 1014 cm2 sr s at 100 PeV. Several independent arrays can be deployed with the aim of constituting a large distributed observatory. Some other sites are already under study. At last, special care is dedicated to the educational and outreach aspects of such a cosmic ray detector.

Study of charged hadron multiplicities in charged-current neutrino-lead interactions in the OPERA detector

NASA Astrophysics Data System (ADS)

Agafonova, N.; Aleksandrov, A.; Anokhina, A.; Aoki, S.; Ariga, A.; Ariga, T.; Bertolin, A.; Bodnarchuk, I.; Bozza, C.; Brugnera, R.; Buonaura, A.; Buontempo, S.; Chernyavskiy, M.; Chukanov, A.; Consiglio, L.; D'Ambrosio, N.; De Lellis, G.; De Serio, M.; del Amo Sanchez, P.; Di Crescenzo, A.; Di Ferdinando, D.; Di Marco, N.; Dmitrievski, S.; Dracos, M.; Duchesneau, D.; Dusini, S.; Dzhatdoev, T.; Ebert, J.; Ereditato, A.; Fini, R. A.; Fornari, F.; Fukuda, T.; Galati, G.; Garfagnini, A.; Gentile, V.; Goldberg, J.; Gornushkin, Y.; Gorbunov, S.; Grella, G.; Guler, A. M.; Gustavino, C.; Hagner, C.; Hara, T.; Hayakawa, T.; Hollnagel, A.; Hosseini, B.; Ishiguro, K.; Jakovcic, K.; Jollet, C.; Kamiscioglu, C.; Kamiscioglu, M.; Kim, S. H.; Kitagawa, N.; Klicek, B.; Kodama, K.; Komatsu, M.; Kose, U.; Kreslo, I.; Laudisio, F.; Lauria, A.; Ljubicic, A.; Longhin, A.; Loverre, P.; Malgin, A.; Malenica, M.; Mandrioli, G.; Matsuo, T.; Matveev, V.; Mauri, N.; Medinaceli, E.; Meregaglia, A.; Mikado, S.; Miyanishi, M.; Mizutani, F.; Monacelli, P.; Montesi, M. C.; Morishima, K.; Muciaccia, M. T.; Naganawa, N.; Naka, T.; Nakamura, M.; Nakano, T.; Niwa, K.; Okateva, N.; Ogawa, S.; Ozaki, K.; Paoloni, A.; Paparella, L.; Park, B. D.; Pasqualini, L.; Pastore, A.; Patrizii, L.; Pessard, H.; Podgrudkov, D.; Polukhina, N.; Pozzato, M.; Pupilli, F.; Roda, M.; Roganova, T.; Rokujo, H.; Rosa, G.; Ryazhskaya, O.; Sato, O.; Schembri, A.; Shakirianova, I.; Shchedrina, T.; Shibuya, H.; Shibayama, E.; Shiraishi, T.; Simone, S.; Sirignano, C.; Sirri, G.; Sotnikov, A.; Spinetti, M.; Stanco, L.; Starkov, N.; Stellacci, S. M.; Stipcevic, M.; Strolin, P.; Takahashi, S.; Tenti, M.; Terranova, F.; Tioukov, V.; Vasina, S.; Vilain, P.; Voevodina, E.; Votano, L.; Vuilleumier, J. L.; Wilquet, G.; Wonsak, B.; Yoon, C. S.

2018-01-01

The OPERA experiment was designed to search for ν _{μ } → ν _{τ } oscillations in appearance mode through the direct observation of tau neutrinos in the CNGS neutrino beam. In this paper, we report a study of the multiplicity of charged particles produced in charged-current neutrino interactions in lead. We present charged hadron average multiplicities, their dispersion and investigate the KNO scaling in different kinematical regions. The results are presented in detail in the form of tables that can be used in the validation of Monte Carlo generators of neutrino-lead interactions.

MAGIC gamma-ray telescopes hunting for neutrinos and their sources

NASA Astrophysics Data System (ADS)

Góra, D.; Bernardini, E.; Satalecka, K.; Noda, K.; Manganaro, M.; López, M.; MAGIC Collaboration

2017-09-01

The discovery of an astrophysical flux of high-energy neutrinos by the IceCube Collaboration marks a major breakthrough in the ongoing search for the origin of cosmic rays. Presumably, the neutrinos, together with gamma rays, result from pion decay, following hadronic interactions of protons accelerated in astrophysical objects to ultra-relativistic energies. So far, the neutrino sky map shows no significant indication of astrophysical sources. Here, we report first results from follow-up observations, of sky regions where IceCube has detected muon tracks from energetic neutrinos, using the MAGIC telescopes which are sensitive to gamma rays at TeV energies. Furthermore, we show that MAGIC has the potential to distinguish air showers induced by tau neutrinos from the background of hadronic showers in the PeV-EeV energy range, employing a novel analysis method to the data obtained with high-zenith angle observations.

Tau lepton polarization in quasielastic neutrino-nucleon scattering

NASA Astrophysics Data System (ADS)

Kuzmin, Konstantin S.; Lyubushkin, Vladimir V.; Naumov, Vadim A.

2005-02-01

We derive structure functions for the quasielastic production of octet baryons in νn and νp interactions and study the polarization of τ leptons produced in the ΔY=0 reactions. Possible impact of the charged second-class currents is investigated by adopting a simple phenomenological parametrization for the nonstandard scalar and tensor nucleon form factors. Our choice of the unknown parameters is made to satisfy the limits obtained in the (anti)neutrino scattering experiments and rigid restrictions derived from the nuclear structure studies.

Comprehensive approach to tau-lepton production by high-energy tau neutrinos propagating through the Earth

NASA Astrophysics Data System (ADS)

Alvarez-Muñiz, Jaime; Carvalho, Washington R.; Payet, Kévin; Romero-Wolf, Andrés; Schoorlemmer, Harm; Zas, Enrique

2018-01-01

There has been a recent surge in interest in the detection of τ -lepton-induced air showers from detectors at altitude. When a τ neutrino (ντ) enters the Earth, it produces τ leptons as a result of nuclear charged-current interactions. In some cases, this process results in a τ lepton exiting the surface of the Earth, which can subsequently decay in the atmosphere and produce an extensive air shower. These upward-going air showers can be detected via fluorescence, optical Cherenkov, or geomagnetic radio emission. Several experiments have been proposed to detect these signals. We present a comprehensive simulation of the production of τ leptons by ντ's propagating through Earth to aid the design of future experiments. These simulations for ντ's and leptons in the energy range from 1 015 eV to 1 021 eV treat the full range of incidence angles from Earth-skimming to diametrically traversing. Propagation of ντ's and leptons includes the effects of rock and an ocean or ice layer of various thicknesses. The interaction models include ντ regeneration and account for uncertainties in the Standard Model neutrino cross section and in the photonuclear contribution to the τ energy-loss rate.

Stochastic mass-reconstruction: a new technique to reconstruct resonance masses of heavy particles decaying into tau lepton pairs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maruyama, Sho

2015-12-15

The invariant mass of tau lepton pairs turns out to be smaller than the resonant mass of their mother particle and the invariant mass distribution is stretched wider than the width of the resonant mass as significant fraction of tau lepton momenta are carried away by neutrinos escaping undetected at collider experiments. This paper describes a new approach to reconstruct resonant masses of heavy particles decaying to tau leptons at such experiments. A typical example is a Z or Higgs boson decaying to a tau pair. Although the new technique can be used for each tau lepton separately, I combinemore » two tau leptons to improve mass resolution by requiring the two tau leptons are lined up in a transverse plane. The method is simple to implement and complementary to the collinear approximation technique that works well when tau leptons are not lined up in a transverse plane. The reconstructed mass can be used as another variable in analyses that already use a visible tau pair mass and missing transverse momentum as these variables are not explicitly used in the stochastic mass-reconstruction to select signal-like events.« less

Thermal dark matter through the Dirac neutrino portal

NASA Astrophysics Data System (ADS)

Batell, Brian; Han, Tao; McKeen, David; Haghi, Barmak Shams Es

2018-04-01

We study a simple model of thermal dark matter annihilating to standard model neutrinos via the neutrino portal. A (pseudo-)Dirac sterile neutrino serves as a mediator between the visible and the dark sectors, while an approximate lepton number symmetry allows for a large neutrino Yukawa coupling and, in turn, efficient dark matter annihilation. The dark sector consists of two particles, a Dirac fermion and complex scalar, charged under a symmetry that ensures the stability of the dark matter. A generic prediction of the model is a sterile neutrino with a large active-sterile mixing angle that decays primarily invisibly. We derive existing constraints and future projections from direct detection experiments, colliders, rare meson and tau decays, electroweak precision tests, and small scale structure observations. Along with these phenomenological tests, we investigate the consequences of perturbativity and scalar mass fine tuning on the model parameter space. A simple, conservative scheme to confront the various tests with the thermal relic target is outlined, and we demonstrate that much of the cosmologically-motivated parameter space is already constrained. We also identify new probes of this scenario such as multibody kaon decays and Drell-Yan production of W bosons at the LHC.

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers.

PubMed

Rubenstein, Richard; Chang, Binggong; Yue, John K; Chiu, Allen; Winkler, Ethan A; Puccio, Ava M; Diaz-Arrastia, Ramon; Yuh, Esther L; Mukherjee, Pratik; Valadka, Alex B; Gordon, Wayne A; Okonkwo, David O; Davies, Peter; Agarwal, Sanjeev; Lin, Fan; Sarkis, George; Yadikar, Hamad; Yang, Zhihui; Manley, Geoffrey T; Wang, Kevin K W; Cooper, Shelly R; Dams-O'Connor, Kristen; Borrasso, Allison J; Inoue, Tomoo; Maas, Andrew I R; Menon, David K; Schnyer, David M; Vassar, Mary J

2017-09-01

Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated. To examine the associations between plasma P-tau and total-tau (T-tau) levels and injury presence, severity, type of pathoanatomic lesion (neuroimaging), and patient outcomes in acute and chronic TBI. In the TRACK-TBI Pilot study, plasma was collected at a single time point from 196 patients with acute TBI admitted to 3 level I trauma centers (<24 hours after injury) and 21 patients with TBI admitted to inpatient rehabilitation units (mean [SD], 176.4 [44.5] days after injury). Control samples were purchased from a commercial vendor. The TRACK-TBI Pilot study was conducted from April 1, 2010, to June 30, 2012. Data analysis for the current investigation was performed from August 1, 2015, to March 13, 2017. Plasma samples were assayed for P-tau (using an antibody that specifically recognizes phosphothreonine-231) and T-tau using ultra-high sensitivity laser-based immunoassay multi-arrayed fiberoptics conjugated with rolling circle amplification. In the 217 patients with TBI, 161 (74.2%) were men; mean (SD) age was 42.5 (18.1) years. The P-tau and T-tau levels and P-tau-T-tau ratio in patients with acute TBI were higher than those in healthy controls. Receiver operating characteristic analysis for the 3 tau indices demonstrated accuracy with area under the curve (AUC) of 1.000, 0.916, and 1.000, respectively, for discriminating mild TBI (Glasgow Coma Scale [GCS] score, 13-15, n = 162) from healthy controls. The P-tau level and P-tau-T-tau ratio were higher in individuals with more severe TBI (GCS, ≤12 vs 13-15). The P-tau level and P-tau-T-tau

An all-sky, three-flavor search for neutrinos from gamma-ray bursts with the icecube neutrino observatory

NASA Astrophysics Data System (ADS)

Hellauer, Robert Eugene, III

Ultra high energy cosmic rays (UHECRs), defined by energy greater than 10. 18 eV, have been observed for decades, but their sources remain unknown. Protons and heavy ions, which comprise cosmic rays, interact with galactic and intergalactic magnetic fields and, consequently, do not point back to their sources upon measurement. Neutrinos, which are inevitably produced in photohadronic interactions, travel unimpeded through the universe and disclose the directions of their sources. Among the most plausible candidates for the origins of UHECRs is a class of astrophysical phenomena known as gamma-ray bursts (GRBs). GRBs are the most violent and energetic events witnessed in the observable universe. The IceCube Neutrino Observatory, located in the glacial ice 1450 m to 2450 m below the South Pole surface, is the largest neutrino detector in operation. IceCube detects charged particles, such as those emitted in high energy neutrino interactions in the ice, by the Cherenkov light radiated by these particles. The measurement of neutrinos of 100 TeV energy or greater in IceCube correlated with gamma-ray photons from GRBs, measured by spacecraft detectors, would provide evidence of hadronic interaction in these powerful phenomena and confirm their role in ultra high energy cosmic ray production. This work presents the first IceCube GRB-neutrino coincidence search optimized for charged-current interactions of electron and tau neutrinos as well as neutral-current interactions of all neutrino flavors, which produce nearly spherical Cherenkov light showers in the ice. These results for three years of data are combined with the results of previous searches over four years of data optimized for charged-current muon neutrino interactions, which produce extended Cherenkov light tracks. Several low significance events correlated with GRBs were detected, but are consistent with the background expectation from atmospheric muons and neutrinos. The combined results produce limits that

Measurement of Neutrino and Antineutrino Charged-Current Inclusive Cross Sections with the MINERvA Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devan, Joshua D.

2015-01-01

Neutrinos are a nearly massless, neutral particle in the Standard Model that only interact via the weak interaction. Experimental confirmation of neutrino oscillations, in which a neutrino created as a particular type (electron, muon or tau) can be observed as a different type after propagating some distance, earned the 2015 Nobel Prize in Physics. Neutrino oscillation experiments rely on accurate measurements of neutrino interactions with matter, such as that presented here. Neutrinos also provide a unique probe of the nucleus, complementary to electron scattering experiments. This thesis presents a measurement of the charged-current inclusive cross section for muon neutrinos and antineutrinos in the energy range 2 to 50 GeV with the MINERvA detector. MINERvA is a neutrino scattering experiment in the NuMI neutrino beam at Fermilab, near Chicago. A cross section measures the probability of an interaction occurring, measured here as a function of neutrino energy. To extract a cross section from data, the observed rate of interactions is corrected for detector efficiency and divided by the number of scattering nucleons in the target and the flux of neutrinos in the beam. The neutrino flux is determined with the low-more » $$\

Three flavor neutrino oscillations in matter: Flavor diagonal potentials, the adiabatic basis, and the CP phase

NASA Astrophysics Data System (ADS)

Kneller, James P.; McLaughlin, Gail C.

2009-09-01

We discuss the three neutrino flavor evolution problem with general, flavor-diagonal, matter potentials and a fully parametrized mixing matrix that includes CP violation, and derive expressions for the eigenvalues, mixing angles, and phases. We demonstrate that, in the limit that the mu and tau potentials are equal, the eigenvalues and matter mixing angles θ˜12 and θ˜13 are independent of the CP phase, although θ˜23 does have CP dependence. Since we are interested in developing a framework that can be used for S matrix calculations of neutrino flavor transformation, it is useful to work in a basis that contains only off-diagonal entries in the Hamiltonian. We derive the “nonadiabaticity” parameters that appear in the Hamiltonian in this basis. We then introduce the neutrino S matrix, derive its evolution equation and the integral solution. We find that this new Hamiltonian, and therefore the S matrix, in the limit that the μ and τ neutrino potentials are the same, is independent of both θ˜23 and the CP violating phase. In this limit, any CP violation in the flavor basis can only be introduced via the rotation matrices, and so effects which derive from the CP phase are then straightforward to determine. We then show explicitly that the electron neutrino and electron antineutrino survival probability is independent of the CP phase in this limit. Conversely, if the CP phase is nonzero and mu and tau matter potentials are not equal, then the electron neutrino survival probability cannot be independent of the CP phase.

Ultrahigh-energy neutrino follow-up of gravitational wave events GW150914 and GW151226 with the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Aab, A.; Abreu, P.; Aglietta, M.; Al Samarai, I.; Albuquerque, I. F. M.; Allekotte, I.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Ambrosio, M.; Anastasi, G. A.; Anchordoqui, L.; Andrada, B.; Andringa, S.; Aramo, C.; Arqueros, F.; Arsene, N.; Asorey, H.; Assis, P.; Aublin, J.; Avila, G.; Badescu, A. M.; Balaceanu, A.; Barreira Luz, R. J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertaina, M. E.; Bertou, X.; Biermann, P. L.; Billoir, P.; Biteau, J.; Blaess, S. G.; Blanco, A.; Blazek, J.; Bleve, C.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Borodai, N.; Botti, A. M.; Brack, J.; Brancus, I.; Bretz, T.; Bridgeman, A.; Briechle, F. L.; Buchholz, P.; Bueno, A.; Buitink, S.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, L.; Cancio, A.; Canfora, F.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chavez, A. G.; Chinellato, J. A.; Chudoba, J.; Clay, R. W.; Colalillo, R.; Coleman, A.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Coutu, S.; Covault, C. E.; Cronin, J.; D'Amico, S.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Jong, S. J.; De Mauro, G.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; Debatin, J.; Deligny, O.; Di Giulio, C.; Di Matteo, A.; Díaz Castro, M. L.; Diogo, F.; Dobrigkeit, C.; D'Olivo, J. C.; Dorofeev, A.; dos Anjos, R. C.; Dova, M. T.; Dundovic, A.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Falcke, H.; Fang, K.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Fick, B.; Figueira, J. M.; Filipčič, A.; Fratu, O.; Freire, M. M.; Fujii, T.; Fuster, A.; Gaior, R.; García, B.; Garcia-Pinto, D.; Gaté, F.; Gemmeke, H.; Gherghel-Lascu, A.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Głas, D.; Glaser, C.; Glass, H.; Golup, G.; Gómez Berisso, M.; Gómez Vitale, P. F.; González, N.; Gookin, B.; Gorgi, A.; Gorham, P.; Gouffon, P.; Grillo, A. F.; Grubb, T. D.; Guarino, F.; Guedes, G. P.; Hampel, M. R.; Hansen, P.; Harari, D.; Harrison, T. A.; Harton, J. L.; Hasankiadeh, Q.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huege, T.; Hulsman, J.; Insolia, A.; Isar, P. G.; Jandt, I.; Jansen, S.; Johnsen, J. A.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Kasper, P.; Katkov, I.; Keilhauer, B.; Kemp, E.; Kemp, J.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Kuempel, D.; Kukec Mezek, G.; Kunka, N.; Kuotb Awad, A.; LaHurd, D.; Lauscher, M.; Lebrun, P.; Legumina, R.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; Lopes, L.; López, R.; López Casado, A.; Luce, Q.; Lucero, A.; Malacari, M.; Mallamaci, M.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Mariş, I. C.; Marsella, G.; Martello, D.; Martinez, H.; Martínez Bravo, O.; Masías Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Melo, D.; Menshikov, A.; Messina, S.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Mockler, D.; Molina-Bueno, L.; Mollerach, S.; Montanet, F.; Morello, C.; Mostafá, M.; Müller, G.; Muller, M. A.; Müller, S.; Naranjo, I.; Nellen, L.; Neuser, J.; Nguyen, P. H.; Niculescu-Oglinzanu, M.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, H.; Núñez, L. A.; Ochilo, L.; Oikonomou, F.; Olinto, A.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Papenbreer, P.; Parente, G.; Parra, A.; Paul, T.; Pech, M.; Pedreira, F.; Pekala, J.; Pelayo, R.; Peña-Rodriguez, J.; Pereira, L. A. S.; Perrone, L.; Peters, C.; Petrera, S.; Phuntsok, J.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porowski, C.; Prado, R. R.; Privitera, P.; Prouza, M.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Ramos-Pollan, R.; Rautenberg, J.; Ravignani, D.; Reinert, D.; Revenu, B.; Ridky, J.; Risse, M.; Ristori, P.; Rizi, V.; Rodrigues de Carvalho, W.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rogozin, D.; Roth, M.; Roulet, E.; Rovero, A. C.; Saffi, S. J.; Saftoiu, A.; Salazar, H.; Saleh, A.; Salesa Greus, F.; Salina, G.; Sanabria Gomez, J. D.; Sánchez, F.; Sanchez-Lucas, P.; Santos, E. M.; Santos, E.; Sarazin, F.; Sarkar, B.; Sarmento, R.; Sarmiento, C. A.; Sato, R.; Schauer, M.; Scherini, V.; Schieler, H.; Schimp, M.; Schmidt, D.; Scholten, O.; Schovánek, P.; Schröder, F. G.; Schulz, A.; Schulz, J.; Schumacher, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sigl, G.; Silli, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sonntag, S.; Sorokin, J.; Squartini, R.; Stanca, D.; Stanič, S.; Stasielak, J.; Stassi, P.; Strafella, F.; Suarez, F.; Suarez Durán, M.; Sudholz, T.; Suomijärvi, T.; Supanitsky, A. D.; Swain, J.; Szadkowski, Z.; Taboada, A.; Taborda, O. A.; Tapia, A.; Theodoro, V. M.; Timmermans, C.; Todero Peixoto, C. J.; Tomankova, L.; Tomé, B.; Torralba Elipe, G.; Torres Machado, D.; Torri, M.; Travnicek, P.; Trini, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van Bodegom, P.; van den Berg, A. M.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Vergara Quispe, I. D.; Verzi, V.; Vicha, J.; Villaseñor, L.; Vorobiov, S.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weindl, A.; Wiencke, L.; Wilczyński, H.; Winchen, T.; Wittkowski, D.; Wundheiler, B.; Wykes, S.; Yang, L.; Yelos, D.; Yushkov, A.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zepeda, A.; Zimmermann, B.; Ziolkowski, M.; Zong, Z.; Zuccarello, F.; Pierre Auger Collaboration

2016-12-01

On September 14, 2015 the Advanced LIGO detectors observed their first gravitational wave (GW) transient GW150914. This was followed by a second GW event observed on December 26, 2015. Both events were inferred to have arisen from the merger of black holes in binary systems. Such a system may emit neutrinos if there are magnetic fields and disk debris remaining from the formation of the two black holes. With the surface detector array of the Pierre Auger Observatory we can search for neutrinos with energy Eν above 100 PeV from pointlike sources across the sky with equatorial declination from about -6 5 ° to +6 0 ° , and, in particular, from a fraction of the 90% confidence-level inferred positions in the sky of GW150914 and GW151226. A targeted search for highly inclined extensive air showers, produced either by interactions of downward-going neutrinos of all flavors in the atmosphere or by the decays of tau leptons originating from tau-neutrino interactions in the Earth's crust (Earth-skimming neutrinos), yielded no candidates in the Auger data collected within ±500 s around or 1 day after the coordinated universal time (UTC) of GW150914 and GW151226, as well as in the same search periods relative to the UTC time of the GW candidate event LVT151012. From the nonobservation we constrain the amount of energy radiated in ultrahigh-energy neutrinos from such remarkable events.

Search for nonstandard neutrino interactions with IceCube DeepCore

NASA Astrophysics Data System (ADS)

Aartsen, M. G.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Ahrens, M.; Al Samarai, I.; Altmann, D.; Andeen, K.; Anderson, T.; Ansseau, I.; Anton, G.; Argüelles, C.; Auffenberg, J.; Axani, S.; Bagherpour, H.; Bai, X.; Barron, J. P.; Barwick, S. W.; Baum, V.; Bay, R.; Beatty, J. J.; Becker Tjus, J.; Becker, K.-H.; BenZvi, S.; Berley, D.; Bernardini, E.; Besson, D. Z.; Binder, G.; Bindig, D.; Blaufuss, E.; Blot, S.; Bohm, C.; Börner, M.; Bos, F.; Bose, D.; Böser, S.; Botner, O.; Bourbeau, E.; Bourbeau, J.; Bradascio, F.; Braun, J.; Brayeur, L.; Brenzke, M.; Bretz, H.-P.; Bron, S.; Brostean-Kaiser, J.; Burgman, A.; Carver, T.; Casey, J.; Casier, M.; Cheung, E.; Chirkin, D.; Christov, A.; Clark, K.; Classen, L.; Coenders, S.; Collin, G. H.; Conrad, J. M.; Cowen, D. F.; Cross, R.; Day, M.; de André, J. P. A. M.; De Clercq, C.; DeLaunay, J. J.; Dembinski, H.; De Ridder, S.; Desiati, P.; de Vries, K. D.; de Wasseige, G.; de With, M.; DeYoung, T.; Díaz-Vélez, J. C.; di Lorenzo, V.; Dujmovic, H.; Dumm, J. P.; Dunkman, M.; Dvorak, E.; Eberhardt, B.; Ehrhardt, T.; Eichmann, B.; Eller, P.; Evenson, P. A.; Fahey, S.; Fazely, A. R.; Felde, J.; Filimonov, K.; Finley, C.; Flis, S.; Franckowiak, A.; Friedman, E.; Fuchs, T.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Ghorbani, K.; Giang, W.; Glauch, T.; Glüsenkamp, T.; Goldschmidt, A.; Gonzalez, J. G.; Grant, D.; Griffith, Z.; Haack, C.; Hallgren, A.; Halzen, F.; Hanson, K.; Hebecker, D.; Heereman, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hignight, J.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Hokanson-Fasig, B.; Hoshina, K.; Huang, F.; Huber, M.; Hultqvist, K.; Hünnefeld, M.; In, S.; Ishihara, A.; Jacobi, E.; Japaridze, G. S.; Jeong, M.; Jero, K.; Jones, B. J. P.; Kalaczynski, P.; Kang, W.; Kappes, A.; Karg, T.; Karle, A.; Katz, U.; Kauer, M.; Keivani, A.; Kelley, J. L.; Kheirandish, A.; Kim, J.; Kim, M.; Kintscher, T.; Kirby, C.; Kiryluk, J.; Kittler, T.; Klein, S. R.; Kohnen, G.; Koirala, R.; Kolanoski, H.; Köpke, L.; Kopper, C.; Kopper, S.; Koschinsky, J. P.; Koskinen, D. J.; Kowalski, M.; Krings, K.; Kroll, M.; Krückl, G.; Kunnen, J.; Kunwar, S.; Kurahashi, N.; Kuwabara, T.; Kyriacou, A.; Labare, M.; Lanfranchi, J. L.; Larson, M. J.; Lauber, F.; Lennarz, D.; Lesiak-Bzdak, M.; Leuermann, M.; Liu, Q. R.; Lu, L.; Lünemann, J.; Luszczak, W.; Madsen, J.; Maggi, G.; Mahn, K. B. M.; Mancina, S.; Maruyama, R.; Mase, K.; Maunu, R.; McNally, F.; Meagher, K.; Medici, M.; Meier, M.; Menne, T.; Merino, G.; Meures, T.; Miarecki, S.; Micallef, J.; Momenté, G.; Montaruli, T.; Moore, R. W.; Moulai, M.; Nahnhauer, R.; Nakarmi, P.; Naumann, U.; Neer, G.; Niederhausen, H.; Nowicki, S. C.; Nygren, D. R.; Obertacke Pollmann, A.; Olivas, A.; O'Murchadha, A.; Palczewski, T.; Pandya, H.; Pankova, D. V.; Peiffer, P.; Pepper, J. A.; Pérez de los Heros, C.; Pieloth, D.; Pinat, E.; Plum, M.; Price, P. B.; Przybylski, G. T.; Raab, C.; Rädel, L.; Rameez, M.; Rawlins, K.; Rea, I. C.; Reimann, R.; Relethford, B.; Relich, M.; Resconi, E.; Rhode, W.; Richman, M.; Robertson, S.; Rongen, M.; Rott, C.; Ruhe, T.; Ryckbosch, D.; Rysewyk, D.; Sälzer, T.; Sanchez Herrera, S. E.; Sandrock, A.; Sandroos, J.; Santander, M.; Sarkar, S.; Sarkar, S.; Satalecka, K.; Schlunder, P.; Schmidt, T.; Schneider, A.; Schoenen, S.; Schöneberg, S.; Schumacher, L.; Seckel, D.; Seunarine, S.; Soedingrekso, J.; Soldin, D.; Song, M.; Spiczak, G. M.; Spiering, C.; Stachurska, J.; Stamatikos, M.; Stanev, T.; Stasik, A.; Stettner, J.; Steuer, A.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Strotjohann, N. L.; Stuttard, T.; Sullivan, G. W.; Sutherland, M.; Taboada, I.; Tatar, J.; Tenholt, F.; Ter-Antonyan, S.; Terliuk, A.; Tešić, G.; Tilav, S.; Toale, P. A.; Tobin, M. N.; Toscano, S.; Tosi, D.; Tselengidou, M.; Tung, C. F.; Turcati, A.; Turley, C. F.; Ty, B.; Unger, E.; Usner, M.; Vandenbroucke, J.; Van Driessche, W.; van Eijndhoven, N.; Vanheule, S.; van Santen, J.; Vehring, M.; Vogel, E.; Vraeghe, M.; Walck, C.; Wallace, A.; Wallraff, M.; Wandler, F. D.; Wandkowsky, N.; Waza, A.; Weaver, C.; Weiss, M. J.; Wendt, C.; Werthebach, J.; Westerhoff, S.; Whelan, B. J.; Wiebe, K.; Wiebusch, C. H.; Wille, L.; Williams, D. R.; Wills, L.; Wolf, M.; Wood, J.; Wood, T. R.; Woolsey, E.; Woschnagg, K.; Xu, D. L.; Xu, X. W.; Xu, Y.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Yuan, T.; Zoll, M.; IceCube Collaboration

2018-04-01

As atmospheric neutrinos propagate through the Earth, vacuumlike oscillations are modified by Standard Model neutral- and charged-current interactions with electrons. Theories beyond the Standard Model introduce heavy, TeV-scale bosons that can produce nonstandard neutrino interactions. These additional interactions may modify the Standard Model matter effect producing a measurable deviation from the prediction for atmospheric neutrino oscillations. The result described in this paper constrains nonstandard interaction parameters, building upon a previous analysis of atmospheric muon-neutrino disappearance with three years of IceCube DeepCore data. The best fit for the muon to tau flavor changing term is ɛμ τ=-0.0005 , with a 90% C.L. allowed range of -0.0067 <ɛμ τ<0.0081 . This result is more restrictive than recent limits from other experiments for ɛμ τ. Furthermore, our result is complementary to a recent constraint on ɛμ τ using another publicly available IceCube high-energy event selection. Together, they constitute the world's best limits on nonstandard interactions in the μ -τ sector.

Phenomenology of ultrahigh energy neutrino interactions and fluxes

NASA Astrophysics Data System (ADS)

Hussain, Shahid

optical Cherenkov radiation they produce; showers can also be detected by the coherent radio Cherenkov signal they produce which is much powerful than their optical Cherenkov signal. We give the formalism for calculating muon, tau, and shower rates for the optical (ICECUBE- like) and the shower rates for the radio (RICE-like) Cherenkov detectors. Our focus is on simulation of the radio signal from neutrino-initiated showers and calculation of the expected neutrino-initiated shower rates for RICE. Finally, given the calculated rates for muons, taus, and showers, we discuss what we can say about the models for UHE neutrino fluxes and interactions.

Measurement of top quark pair production cross section in proton antiproton collisions at center of mass energy 1.96TeV in the tau+ jets final state using 1fb-1 of data

NASA Astrophysics Data System (ADS)

Hossain, Sohrab

This dissertation presents a new measurement of pp¯ → tt¯X production at s = 1.96 TeV using 974.2 pb-1 of data collected with the DO detector between 2002 and 2006. We focus on the final state where the W boson from one of the top quarks decays into a tau lepton and its associated neutrino, while the other W boson decays into a quark-antiquark pair. We aim to select those events in which the tau lepton subsequently decays hadronically, meaning to one or three charged hadrons, zero or more neutral hadrons and a tau neutrino (the charge conjugate processes are implied in all of the above). The observable signature thus consists of a narrow calorimeter shower with associated track(s) characteristic of a hadronic tau decay, four or more jets, of which two are initiated by b quarks accompanying the W's in the top quark decays, and a large net missing momentum in the transverse plane due to the energetic neutrino-antineutrino pair that leave no trace in the detector media. The preliminary result for the measured cross section is: stt= 6.9+1.2-1.2 stat +0.8-0.7 syst +/-0.4lumi pb. This indicates that our finding is consistent with the Standard Model prediction.

Improved limit to the diffuse flux of ultrahigh energy neutrinos from the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Aab, A.; Abreu, P.; Aglietta, M.; Ahn, E. J.; Al Samarai, I.; Albuquerque, I. F. M.; Allekotte, I.; Allison, P.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Alves Batista, R.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Aramo, C.; Aranda, V. M.; Arqueros, F.; Arsene, N.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Awal, N.; Badescu, A. M.; Barber, K. B.; Bäuml, J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertaina, M. E.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blaess, S. G.; Blanco, A.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Borodai, N.; Brack, J.; Brancus, I.; Bridgeman, A.; Brogueira, P.; Brown, W. C.; Buchholz, P.; Bueno, A.; Buitink, S.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, B.; Caccianiga, L.; Candusso, M.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chavez, A. G.; Chiavassa, A.; Chinellato, J. A.; Chudoba, J.; Cilmo, M.; Clay, R. W.; Cocciolo, G.; Colalillo, R.; Coleman, A.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Cordier, A.; Coutu, S.; Covault, C. E.; Cronin, J.; Dallier, R.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Jong, S. J.; De Mauro, G.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; del Peral, L.; Deligny, O.; Dembinski, H.; Dhital, N.; Di Giulio, C.; Di Matteo, A.; Diaz, J. C.; Díaz Castro, M. L.; Diogo, F.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dorofeev, A.; Dorosti Hasankiadeh, Q.; Dova, M. T.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Falcke, H.; Fang, K.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Fernandes, M.; Fick, B.; Figueira, J. M.; Filevich, A.; Filipčič, A.; Fox, B. D.; Fratu, O.; Freire, M. M.; Fuchs, B.; Fujii, T.; García, B.; Garcia-Pinto, D.; Gate, F.; Gemmeke, H.; Gherghel-Lascu, A.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Głas, D.; Glaser, C.; Glass, H.; Golup, G.; Gómez Berisso, M.; Gómez Vitale, P. F.; González, N.; Gookin, B.; Gordon, J.; Gorgi, A.; Gorham, P.; Gouffon, P.; Griffith, N.; Grillo, A. F.; Grubb, T. D.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hampel, M. R.; Hansen, P.; Harari, D.; Harrison, T. A.; Hartmann, S.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Hollon, N.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huber, D.; Huege, T.; Insolia, A.; Isar, P. G.; Jandt, I.; Jansen, S.; Jarne, C.; Johnsen, J. A.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Kasper, P.; Katkov, I.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Krömer, O.; Kuempel, D.; Kunka, N.; LaHurd, D.; Latronico, L.; Lauer, R.; Lauscher, M.; Lautridou, P.; Le Coz, S.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; Lopes, L.; López, R.; López Casado, A.; Louedec, K.; Lu, L.; Lucero, A.; Malacari, M.; Maldera, S.; Mallamaci, M.; Maller, J.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Mariş, I. C.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Martínez Bravo, O.; Martraire, D.; Masías Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Maurel, D.; Maurizio, D.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Meissner, R.; Mello, V. B. B.; Melo, D.; Menshikov, A.; Messina, S.; Meyhandan, R.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Molina-Bueno, L.; Mollerach, S.; Montanet, F.; Morello, C.; Mostafá, M.; Moura, C. A.; Muller, M. A.; Müller, G.; Müller, S.; Mussa, R.; Navarra, G.; Navarro, J. L.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Neuser, J.; Nguyen, P. H.; Niculescu-Oglinzanu, M.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, L.; Ochilo, L.; Oikonomou, F.; Olinto, A.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Papenbreer, P.; Parente, G.; Parra, A.; Paul, T.; Pech, M.; PÈ©kala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Petermann, E.; Peters, C.; Petrera, S.; Petrov, Y.; Phuntsok, J.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porcelli, A.; Porowski, C.; Prado, R. R.; Privitera, P.; Prouza, M.; Purrello, V.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rizi, V.; Rodrigues de Carvalho, W.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rodríguez-Frías, M. D.; Rogozin, D.; Rosado, J.; Roth, M.; Roulet, E.; Rovero, A. C.; Saffi, S. J.; Saftoiu, A.; Salamida, F.; Salazar, H.; Saleh, A.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Sanchez-Lucas, P.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarmento, R.; Sato, R.; Scarso, C.; Schauer, M.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, D.; Scholten, O.; Schoorlemmer, H.; Schovánek, P.; Schröder, F. G.; Schulz, A.; Schulz, J.; Schumacher, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Squartini, R.; Srivastava, Y. N.; Stanca, D.; Stanič, S.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Taborda, O. A.; Tapia, A.; Tepe, A.; Theodoro, V. M.; Tiffenberg, J.; Timmermans, C.; Todero Peixoto, C. J.; Toma, G.; Tomankova, L.; Tomé, B.; Tonachini, A.; Torralba Elipe, G.; Torres Machado, D.; Travnicek, P.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van Bodegom, P.; van den Berg, A. M.; van Velzen, S.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vasquez, R.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Vlcek, B.; Vorobiov, S.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Werner, F.; Widom, A.; Wiencke, L.; Wilczyński, H.; Winchen, T.; Wittkowski, D.; Wundheiler, B.; Wykes, S.; Yang, L.; Yapici, T.; Yushkov, A.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zepeda, A.; Zhu, Y.; Zimmermann, B.; Ziolkowski, M.; Zuccarello, F.; Pierre Auger Collaboration

2015-05-01

Neutrinos in the cosmic ray flux with energies near 1 EeV and above are detectable with the Surface Detector array (SD) of the Pierre Auger Observatory. We report here on searches through Auger data from 1 January 2004 until 20 June 2013. No neutrino candidates were found, yielding a limit to the diffuse flux of ultrahigh energy neutrinos that challenges the Waxman-Bahcall bound predictions. Neutrino identification is attempted using the broad time structure of the signals expected in the SD stations, and is efficiently done for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for "Earth-skimming" neutrino interactions in the case of tau neutrinos. In this paper the searches for downward-going neutrinos in the zenith angle bins 60°-75° and 75°-90° as well as for upward-going neutrinos, are combined to give a single limit. The 90% C.L. single-flavor limit to the diffuse flux of ultrahigh energy neutrinos with an E-2 spectrum in the energy range 1.0 ×1 017 eV - 2.5 ×1 019 eV is Eν2d Nν/d Eν<6.4 ×10-9 GeV cm-2 s-1 sr-1 .

Ultrahigh-energy neutrino follow-up of gravitational wave events GW150914 and GW151226 with the Pierre Auger Observatory

DOE PAGES

Aab, A.; Abreu, P.; Aglietta, M.; ...

2016-12-30

On September 14, 2015 the Advanced LIGO detectors observed their first gravitational wave (GW) transient GW150914. This was followed by a second GW event observed on December 26, 2015. Both events were inferred to have arisen from the merger of black holes in binary systems. Such a system may emit neutrinos if there are magnetic fields and disk debris remaining from the formation of the two black holes. With the surface detector array of the Pierre Auger Observatory we can search for neutrinos with energy Eν above 100 PeV from point like sources across the sky with equatorial declination from aboutmore » -65° to +60°, and, in particular, from a fraction of the 90% confidence-level inferred positions in the sky of GW150914 and GW151226. A targeted search for highly inclined extensive air showers, produced either by interactions of downward-going neutrinos of all flavors in the atmosphere or by the decays of tau leptons originating from tau-neutrino interactions in the Earth’s crust (Earth-skimming neutrinos), yielded no candidates in the Auger data collected within ±500 s around or 1 day after the coordinated universal time (UTC) of GW150914 and GW151226, as well as in the same search periods relative to the UTC time of the GW candidate event LVT151012. As a result, from the non-observation we constrain the amount of energy radiated in ultrahigh-energy neutrinos from such remarkable events.« less

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice

PubMed Central

Garringer, Holly J.; Murrell, Jill; Sammeta, Neeraja; Gnezda, Anita; Ghetti, Bernardino; Vidal, Ruben

2013-01-01

Familial Danish dementia (FDD) is an autosomal dominant neurodegenerative disease caused by a 10-nucleotide duplication-insertion in the BRI2 gene. FDD is clinically characterized by loss of vision, hearing impairment, cerebellar ataxia and dementia. The main neuropathologic findings in FDD are the deposition of Danish amyloid (ADan) and the presence of neurofibrillary tangles (NFTs). Here we investigated tau accumulation and truncation in double transgenic (Tg-FDD-Tau) mice generated by crossing transgenic mice expressing human Danish mutant BRI2 (Tg-FDD) with mice expressing human 4-repeat mutant Tau-P301S (Tg-Tau). Compared to Tg-Tau mice, we observed a significant enhancement of tau deposition in Tg-FDD-Tau mice. In addition, a significant increase in tau cleaved at aspartic acid (Asp) 421 was observed in Tg-FDD-Tau mice. Tg-FDD-Tau mice also showed a significant decrease in synaptophysin levels, occurring before widespread deposition of fibrillar ADan and tau can be observed. Thus, the presence of soluble ADan/mutant BRI2 can lead to significant changes in tau metabolism and synaptic dysfunction. Our data provide new in vivo insights into the pathogenesis of FDD and the pathogenic pathway(s) by which amyloidogenic peptides, regardless of their primary amino acid sequence, can cause neurodegeneration. PMID:23418567

Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.

PubMed

Garringer, Holly J; Murrell, Jill; Sammeta, Neeraja; Gnezda, Anita; Ghetti, Bernardino; Vidal, Ruben

2013-01-01

Familial Danish dementia (FDD) is an autosomal dominant neurodegenerative disease caused by a 10-nucleotide duplication-insertion in the BRI(2) gene. FDD is clinically characterized by loss of vision, hearing impairment, cerebellar ataxia and dementia. The main neuropathologic findings in FDD are the deposition of Danish amyloid (ADan) and the presence of neurofibrillary tangles (NFTs). Here we investigated tau accumulation and truncation in double transgenic (Tg-FDD-Tau) mice generated by crossing transgenic mice expressing human Danish mutant BRI(2) (Tg-FDD) with mice expressing human 4-repeat mutant Tau-P301S (Tg-Tau). Compared to Tg-Tau mice, we observed a significant enhancement of tau deposition in Tg-FDD-Tau mice. In addition, a significant increase in tau cleaved at aspartic acid (Asp) 421 was observed in Tg-FDD-Tau mice. Tg-FDD-Tau mice also showed a significant decrease in synaptophysin levels, occurring before widespread deposition of fibrillar ADan and tau can be observed. Thus, the presence of soluble ADan/mutant BRI(2) can lead to significant changes in tau metabolism and synaptic dysfunction. Our data provide new in vivo insights into the pathogenesis of FDD and the pathogenic pathway(s) by which amyloidogenic peptides, regardless of their primary amino acid sequence, can cause neurodegeneration.

Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation

PubMed Central

Cohen, Todd J.; Constance, Brian H.; Hwang, Andrew W.; James, Michael; Yuan, Chao-Xing

2016-01-01

Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer’s disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for normal tau function and its pathological aggregation. Here, we demonstrate that tau isoforms have different propensities to undergo lysine acetylation, with auto-acetylation occurring more prominently within the lysine-rich microtubule-binding repeats. Unexpectedly, we identified a unique intrinsic property of tau in which auto-acetylation induces proteolytic tau cleavage, thereby generating distinct N- and C-terminal tau fragments. Supporting a catalytic reaction-based mechanism, mapping and mutagenesis studies showed that tau cysteines, which are required for acetyl group transfer, are also essential for auto-proteolytic tau processing. Further mass spectrometry analysis identified the C-terminal 2nd and 4th microtubule binding repeats as potential sites of auto-cleavage. The identification of acetylation-mediated auto-proteolysis provides a new biochemical mechanism for tau self-regulation and warrants further investigation into whether auto-catalytic functions of tau are implicated in AD and other tauopathies. PMID:27383765

Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation.

PubMed

Cohen, Todd J; Constance, Brian H; Hwang, Andrew W; James, Michael; Yuan, Chao-Xing

2016-01-01

Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer's disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for normal tau function and its pathological aggregation. Here, we demonstrate that tau isoforms have different propensities to undergo lysine acetylation, with auto-acetylation occurring more prominently within the lysine-rich microtubule-binding repeats. Unexpectedly, we identified a unique intrinsic property of tau in which auto-acetylation induces proteolytic tau cleavage, thereby generating distinct N- and C-terminal tau fragments. Supporting a catalytic reaction-based mechanism, mapping and mutagenesis studies showed that tau cysteines, which are required for acetyl group transfer, are also essential for auto-proteolytic tau processing. Further mass spectrometry analysis identified the C-terminal 2nd and 4th microtubule binding repeats as potential sites of auto-cleavage. The identification of acetylation-mediated auto-proteolysis provides a new biochemical mechanism for tau self-regulation and warrants further investigation into whether auto-catalytic functions of tau are implicated in AD and other tauopathies.

Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro.

PubMed

Paranjape, Smita R; Riley, Andrew P; Somoza, Amber D; Oakley, C Elizabeth; Wang, Clay C C; Prisinzano, Thomas E; Oakley, Berl R; Gamblin, T Chris

2015-05-20

The aggregation of the microtubule-associated protein tau is a seminal event in many neurodegenerative diseases, including Alzheimer's disease. The inhibition or reversal of tau aggregation is therefore a potential therapeutic strategy for these diseases. Fungal natural products have proven to be a rich source of useful compounds having wide varieties of biological activities. We have previously screened Aspergillus nidulans secondary metabolites for their ability to inhibit tau aggregation in vitro using an arachidonic acid polymerization protocol. One aggregation inhibitor identified was asperbenzaldehyde, an intermediate in azaphilone biosynthesis. We therefore tested 11 azaphilone derivatives to determine their tau assembly inhibition properties in vitro. All compounds tested inhibited tau filament assembly to some extent, and four of the 11 compounds had the advantageous property of disassembling preformed tau aggregates in a dose-dependent fashion. The addition of these compounds to the tau aggregates reduced both the total length and number of tau polymers. The most potent compounds were tested in in vitro reactions to determine whether they interfere with tau's normal function of stabilizing microtubules (MTs). We found that they did not completely inhibit MT assembly in the presence of tau. These derivatives are very promising lead compounds for tau aggregation inhibitors and, more excitingly, for compounds that can disassemble pre-existing tau filaments. They also represent a new class of anti-tau aggregation compounds with a novel structural scaffold.

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau.

PubMed

Lasagna-Reeves, Cristian A; Castillo-Carranza, Diana L; Sengupta, Urmi; Guerrero-Munoz, Marcos J; Kiritoshi, Takaki; Neugebauer, Volker; Jackson, George R; Kayed, Rakez

2012-01-01

Intracerebral injection of brain extracts containing amyloid or tau aggregates in transgenic animals can induce cerebral amyloidosis and tau pathology. We extracted pure populations of tau oligomers directly from the cerebral cortex of Alzheimer disease (AD) brain. These oligomers are potent inhibitors of long term potentiation (LTP) in hippocampal brain slices and disrupt memory in wild type mice. We observed for the first time that these authentic brain-derived tau oligomers propagate abnormal tau conformation of endogenous murine tau after prolonged incubation. The conformation and hydrophobicity of tau oligomers play a critical role in the initiation and spread of tau pathology in the naïve host in a manner reminiscent of sporadic AD.

What can we learn on supernova neutrino spectra with water Cherenkov detectors?

NASA Astrophysics Data System (ADS)

Gallo Rosso, Andrea; Vissani, Francesco; Volpe, Maria Cristina

2018-04-01

We investigate the precision with which the supernova neutrino spectra can be reconstructed in water Cherenkov detectors, in particular the large scale Hyper-Kamiokande and Super-Kamiokande. To this aim, we consider quasi-thermal neutrino spectra modified by the Mikheev-Smirnov-Wolfenstein effect for the case of normal ordering. We perform three 9 degrees of freedom likelihood analyses including first inverse-beta decay only, then the combination of inverse beta decay and elastic scattering on electrons and finally a third analysis that also includes neutral scattering neutrino-oxygen events. A tenth parameter is added in the analyses to account for the theoretical uncertainty on the neutral current neutrino-oxygen cross section. By assuming a 100% efficiency in Hyper-Kamiokande, we show that one can reconstruct the electron antineutrino average energy and pinching parameter with an accuracy of ~2% and ~7% percent respectively, while the antineutrino integrated luminosity can be pinned down at ~3% percent level. As for the muon and tau neutrinos, the average energy and the integrated luminosity can be measured with ~7% precision. These results represent a significant improvement with respect Super-Kamiokande, particularly for the pinching parameter defining the electron antineutrino spectra. As for electron neutrinos, the determination of the emission parameters requires the addition of supplementary detection channels.

Bounds on the Coupling of the Majoron to Light Neutrinos from Supernova Cooling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farzan, Yasaman

2002-12-02

We explore the role of Majoron (J) emission in the supernova cooling process, as a source of upper bound on the neutrino-Majoron coupling. We show that the strongest upper bound on the coupling to {nu}{sub 3} comes from the {nu}{sub e}{nu}{sub e} {yields} J process in the core of a supernova. We also find bounds on diagonal couplings of the Majoron to {nu}{sub {mu}({tau})}{nu}{sub {mu}({tau})} and on off-diagonal {nu}{sub e}{nu}{sub {mu}({tau})} couplings in various regions of the parameter space. We discuss the evaluation of cross-section for four-particle interactions ({nu}{nu} {yields} JJ and {nu}J {yields} {nu}J). We show that these aremore » typically dominated by three-particle sub-processes and do not give new independent constraints.« less

Improved limit to the diffuse flux of ultrahigh energy neutrinos from the Pierre Auger Observatory

DOE PAGES

Aab, Alexander

2015-05-26

Neutrinos in the cosmic ray flux with energies near 1 EeV and above are detectable with the Surface Detector array (SD) of the Pierre Auger Observatory. We report here on searches through Auger data from 1 January 2004 until 20 June 2013. No neutrino candidates were found, yielding a limit to the diffuse flux of ultrahigh energy neutrinos that challenges the Waxman-Bahcall bound predictions. Neutrino identification is attempted using the broad time structure of the signals expected in the SD stations, and is efficiently done for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as wellmore » as for “Earth-skimming” neutrino interactions in the case of tau neutrinos. In this paper the searches for downward-going neutrinos in the zenith angle bins 60°–75° and 75°–90° as well as for upward-going neutrinos, are combined to give a single limit. In addition, the 90% C.L. single-flavor limit to the diffuse flux of ultrahigh energy neutrinos with an E –2 spectrum in the energy range 1.0 × 10 17 eV – 2.5 × 10 19 eV is E 2 νdN ν/dE ν < 6.4 × 10 –9 GeV cm –2 s –1 sr –1.« less

Discovering intermediate mass sterile neutrinos through τ-→π-μ-e+ν (or ν ¯ ) decay

NASA Astrophysics Data System (ADS)

Kim, C. S.; López Castro, G.; Sahoo, Dibyakrupa

2017-10-01

Distinguishing the Dirac and Majorana nature of neutrinos remains one of the most important tasks in neutrino physics. By assuming that the τ-→π-μ-e+ν (or ν ¯ ) decay is resonantly enhanced by the exchange of an intermediate mass sterile neutrino N , we show that the energy spectrum of emitted pions and muons can be used to easily distinguish between the Dirac and Majorana nature of N . This method takes advantage of the fact that the flavor of light neutrinos is not identified in the tau decay under consideration. We find that it is particularly advantageous, because of no competing background events, to search for N in the mass range me+mμ≤mN≤mμ+mπ, where mX denotes the mass of particle X ∈{e ,μ ,π ,N }.

Long baseline neutrino oscillation experiment at the AGS

NASA Astrophysics Data System (ADS)

Beavis, D.; Carroll, A.; Chiang, I.

1995-04-01

The authors present a design for a multidetector long baseline neutrino oscillation experiment at the BNL AGS. It has been approved by the BNL-HENP-PAC as AGS Experiment 889. The experiment will search for oscillations in the nu(sub mu) disappearance channel and the nu(sub mu) reversible reaction nu(sub e) appearance channel by means of four identical neutrino detectors located 1, 3, 24, and 68 km from the AGS neutrino source. Observed depletion of the nu(sub mu) flux (via quasi-elastic muon neutrino events, nu(sub mu)n yields mu(-)p) in the far detectors not attended by an observed proportional increase of the nu(sub e) flux (via quasi-elastic electron neutrino events, nu(sub e)n yields e(-)p) in those detectors will be prima facie evidence for the oscillation channel nu(sub mu) reversible reaction nu(sub tau). The experiment is directed toward exploration of the region of the neutrino oscillation parameters Delta m(exp 2) and sin(exp 2) 2 theta, suggested by the Kamiokande and IMB deep underground detectors but it will also explore a region more than two orders of magnitude larger than that of previous accelerator experiments. The experiment will run in a mode new to BNL. It will receive the fast extracted proton beam on the neutrino target approximately 20 hours per day when the AGS is not filling RHIC. A key aspect of the experimental design involves placing the detectors 1.5 degrees off the center line of the neutrino beam, which has the important advantage that the central value of the neutrino energy (approximately 1 GeV) and the beam spectral shape are, to a good approximation, the same in all four detectors. The proposed detectors are massive, imaging, water Cherenkov detectors similar in large part to the Kamiokande and IMB detectors. The design has profited from their decade-long experience, and from the detector designs of the forthcoming SNO and SuperKamiokande detectors.

Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro.

PubMed

Rane, Jitendra Subhash; Bhaumik, Prasenjit; Panda, Dulal

2017-01-01

The pathological aggregation of tau is a common feature of most of the neuronal disorders including frontotemporal dementia, Parkinson's disease, and Alzheimer's disease. The inhibition of tau aggregation is considered to be one of the important strategies for treating these neurodegenerative diseases. Curcumin, a natural polyphenolic molecule, has been reported to have neuroprotective ability. In this work, curcumin was found to bind to adult tau and fetal tau with a dissociation constant of 3.3±0.4 and 8±1 μM, respectively. Molecular docking studies indicated a putative binding site of curcumin in the microtubule-binding region of tau. Using several complementary techniques, including dynamic light scattering, thioflavin S fluorescence, 90° light scattering, electron microscopy, and atomic force microscopy, curcumin was found to inhibit the aggregation of tau. The dynamic light scattering analysis and atomic force microscopic images revealed that curcumin inhibits the oligomerization of tau. Curcumin also disintegrated preformed tau oligomers. Using Far-UV circular dichroism, curcumin was found to inhibit the β-sheets formation in tau indicating that curcumin inhibits an initial step of tau aggregation. In addition, curcumin inhibited tau fibril formation. Furthermore, the effect of curcumin on the preformed tau filaments was analyzed by atomic force microscopy, transmission electron microscopy, and 90° light scattering. Curcumin treatment disintegrated preformed tau filaments. The results indicated that curcumin inhibited the oligomerization of tau and could disaggregate tau filaments.

Probing possible decoherence effects in atmospheric neutrino oscillations.

PubMed

Lisi, E; Marrone, A; Montanino, D

2000-08-07

It is shown that the results of the Super-Kamiokande atmospheric neutrino experiment, interpreted in terms of nu(mu)<-->nu(tau) flavor transitions, can probe possible decoherence effects induced by new physics (e.g., by quantum gravity) with high sensitivity, supplementing current laboratory tests based on kaon oscillations and on neutron interferometry. By varying the (unknown) energy dependence of such effects, one can either obtain strong limits on their amplitude or use them to find an unconventional solution to the atmospheric nu anomaly based solely on decoherence.

Studies of non-standard effects in atmospheric neutrino oscillations of Super-Kamiokande

NASA Astrophysics Data System (ADS)

Wang, Wei

that the oscillation between muon neutrinos and tau neutrinos is the best model explaining SK atmospheric neutrino data among the models we test. In most cases, limits on new physics established in this study using SK atmospheric neutrino data are the best currently available.

Rethinking antiparticles. Hermann Weyl's contribution to neutrino physics

NASA Astrophysics Data System (ADS)

De Bianchi, Silvia

2018-02-01

This paper focuses on Hermann Weyl's two-component theory and frames it within the early development of different theories of spinors and the history of the discovery of parity violation in weak interactions. In order to show the implications of Weyl's theory, the paper discusses the case study of Ettore Majorana's symmetric theory of electron and positron (1937), as well as its role in inspiring Case's formulation of parity violation for massive neutrinos in 1957. In doing so, this paper clarifies the relevance of Weyl's and Majorana's theories for the foundations of neutrino physics and emphasizes which conceptual aspects of Weyl's approach led to Lee's and Yang's works on neutrino physics and to the solution of the theta-tau puzzle in 1957. This contribution thus sheds a light on the alleged "re-discovery" of Weyl's and Majorana's theories in 1957, by showing that this did not happen all of a sudden. On the contrary, the scientific community was well versed in applying these theories in the 1950s on the ground of previous studies that involved important actors in both Europe and United States.

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

PubMed Central

Yanamandra, Kiran; Patel, Tirth K.; Jiang, Hong; Schindler, Suzanne; Ulrich, Jason D.; Boxer, Adam L.; Miller, Bruce L.; Kerwin, Diana R.; Gallardo, Gilbert; Stewart, Floy; Finn, Mary Beth; Cairns, Nigel J.; Verghese, Philip B.; Fogelman, Ilana; West, Tim; Braunstein, Joel; Robinson, Grace; Keyser, Jennifer; Roh, Joseph; Knapik, Stephanie S.; Hu, Yan; Holtzman, David M.

2017-01-01

Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A promising treatment being explored for tauopathies is passive immunization with anti-tau antibodies. We previously found that administration of an anti-tau antibody to human tau transgenic mice increased the concentration of plasma tau. We further explored the effects of administering an anti-tau antibody on plasma tau. After peripheral administration of an anti-tau antibody to human patients with tauopathy and to mice expressing human tau in the central nervous system, there was a dose-dependent increase in plasma tau. In mouse plasma, we found that tau had a short half-life of 8 min that increased to more than 3 hours after administration of anti-tau antibody. As tau transgenic mice accumulated insoluble tau in the brain, brain soluble and interstitial fluid tau decreased. Administration of anti-tau antibody to tau transgenic mice that had decreased brain soluble tau and interstitial fluid tau resulted in an increase in plasma tau, but this increase was less than that observed in tau transgenic mice without these brain changes. Tau transgenic mice subjected to acute neuronal injury using 3-nitropropionic acid showed increased interstitial fluid tau and plasma tau. These data suggest that peripheral administration of an anti-tau antibody results in increased plasma tau, which correlates with the concentration of extracellular and soluble tau in the brain. PMID:28424326

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers

PubMed Central

Rubenstein, Richard; Chang, Binggong; Yue, John K.; Chiu, Allen; Winkler, Ethan A.; Puccio, Ava M.; Diaz-Arrastia, Ramon; Yuh, Esther L.; Mukherjee, Pratik; Valadka, Alex B.; Gordon, Wayne A.; Okonkwo, David O.; Davies, Peter; Agarwal, Sanjeev; Lin, Fan; Sarkis, George; Yadikar, Hamad; Yang, Zhihui; Manley, Geoffrey T.; Wang, Kevin K. W.

2017-01-01

IMPORTANCE Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated. OBJECTIVE To examine the associations between plasma P-tau and total-tau (T-tau) levels and injury presence, severity, type of pathoanatomic lesion (neuroimaging), and patient outcomes in acute and chronic TBI. DESIGN, SETTING, AND PARTICIPANTS In the TRACK-TBI Pilot study, plasma was collected at a single time point from 196 patients with acute TBI admitted to 3 level I trauma centers (<24 hours after injury) and 21 patients with TBI admitted to inpatient rehabilitation units (mean [SD], 176.4 [44.5] days after injury). Control samples were purchased from a commercial vendor. The TRACK-TBI Pilot study was conducted from April 1, 2010, to June 30, 2012. Data analysis for the current investigation was performed from August 1, 2015, to March 13, 2017. MAIN OUTCOMES AND MEASURES Plasma samples were assayed for P-tau (using an antibody that specifically recognizes phosphothreonine-231) and T-tau using ultra-high sensitivity laser-based immunoassay multi-arrayed fiberoptics conjugated with rolling circle amplification. RESULTS In the 217 patients with TBI, 161 (74.2%) were men; mean (SD) age was 42.5 (18.1) years. The P-tau and T-tau levels and P-tau–T-tau ratio in patients with acute TBI were higher than those in healthy controls. Receiver operating characteristic analysis for the 3 tau indices demonstrated accuracy with area under the curve (AUC) of 1.000, 0.916, and 1.000, respectively, for discriminating mild TBI (Glasgow Coma Scale [GCS] score, 13–15, n = 162) from healthy controls. The P-tau level and P-tau–T-tau ratio

Closing the tau loop: the missing tau mutation

PubMed Central

McCarthy, Allan; Lonergan, Roisin; Olszewska, Diana A.; O’Dowd, Sean; Cummins, Gemma; Magennis, Brian; Fallon, Emer M.; Pender, Niall; Huey, Edward D.; Cosentino, Stephanie; O’Rourke, Killian; Kelly, Brendan D.; O’Connell, Martin; Delon, Isabelle; Farrell, Michael; Spillantini, Maria Grazia; Rowland, Lewis P.; Fahn, Stanley; Craig, Peter; Hutton, Michael

2015-01-01

Frontotemporal lobar degeneration comprises a group of disorders characterized by behavioural, executive, language impairment and sometimes features of parkinsonism and motor neuron disease. In 1994 we described an Irish-American family with frontotemporal dementia linked to chromosome 17 associated with extensive tau pathology. We named this disinhibition-dementia-parkinsonism-amyotrophy complex. We subsequently identified mutations in the MAPT gene. Eleven MAPT gene splice site stem loop mutations were identified over time except for 5’ splice site of exon 10. We recently identified another Irish family with autosomal dominant early amnesia and behavioural change or parkinsonism associated with the ‘missing’ +15 mutation at the intronic boundary of exon 10. We performed a clinical, neuropsychological and neuroimaging study on the proband and four siblings, including two affected siblings. We sequenced MAPT and performed segregation analysis. We looked for a biological effect of the tau variant by performing real-time polymerase chain reaction analysis of RNA extracted from human embryonic kidney cells transfected with exon trapping constructs. We found a c.915+15A>C exon 10/intron 10 stem loop mutation in all affected subjects but not in the unaffected. The c.915+15A>C variant caused a shift in tau splicing pattern to a predominantly exon 10+ pattern presumably resulting in predominant 4 repeat tau and little 3 repeat tau. This strongly suggests that the c.915+15A>C variant is a mutation and that it causes frontotemporal dementia linked to chromosome 17 in this pedigree by shifting tau transcription and translation to +4 repeat tau. Tau (MAPT) screening should be considered in families where amnesia or atypical parkinsonism coexists with behavioural disturbance early in the disease process. We describe the final missing stem loop tau mutation predicted 15 years ago. Mutations have now been identified at all predicted sites within the ‘stem’ when the

Heavy neutrino decay at SHALON

NASA Astrophysics Data System (ADS)

Sinitsyna, V. G.; Masip, M.; Sinitsyna, V. Y.

2013-06-01

The SHALON Cherenkov telescope has recorded over 2 × 106 extensive air showers during the past 17 years. The analysis of the signal at different zenith angles has included observations from the sub-horizontal direction Θ = 97° This inclination defines an Earth skimming trajectory with 7 km of air and around 1000 km of rock in front of the telescope. During a period of 324 hours of observation, after a cut of shower-like events that may be caused by chaotic sky flashes or reflections on the snow of vertical showers, we have detected 5 air showers of TeV energies. We argue that these events may be caused by the decay of a long-lived penetrating particle entering the atmosphere from the ground and decaying in front of the telescope. We show that this particle can it not be a muon or a tau lepton. As a possible explanation, we discuss two scenarios with an unstable neutrino of mass m ≈ 0.5 GeV and cτ ≈ 30 m. Remarkably, one of these models has been recently proposed to explain an excess of electron-like neutrino events at MiniBooNE.

Detecting tau in serum of transgenic animal models after tau immunotherapy treatment.

PubMed

d'Abramo, Cristina; Acker, Christopher M; Schachter, Joel B; Terracina, Giuseppe; Wang, Xiaohai; Forest, Stefanie K; Davies, Peter

2016-01-01

In the attempt to elucidate if the "peripheral sink hypothesis" could be a potential mechanism of action for tau removal in passive immunotherapy experiments, we have examined tau levels in serum of chronically injected JNPL3 and Tg4510 transgenic animals. Measurement of tau in serum of mice treated with tau antibodies is challenging because of the antibody interference in sandwich enzyme-linked immunosorbent assays. To address this issue, we have developed a heat-treatment protocol at acidic pH to remove interfering molecules from serum, with excellent recovery of tau. The present data show that pan-tau and conformational antibodies do increase tau in mouse sera. However, these concentrations in serum do not consistently correlate with reductions of tau pathology in brain, suggesting that large elevations of tau species measured in serum are not predictive of efficacy. Here, we describe a reliable method to detect tau in serum of transgenic animals that have undergone tau immunotherapy. Levels of tau in human serum are less than the sensitivity of current assays, although artifactual signals are common. The method may be useful in similarly treated humans, a situation in which false positive signals are likely. Copyright © 2016 Elsevier Inc. All rights reserved.

Tau Phosphorylation Pathway Genes and Cerebrospinal Fluid Tau Levels in Alzheimer’s Disease

PubMed Central

Bekris, Lynn M.; Millard, Steve; Lutz, Franziska; Li, Gail; Galasko, Doug R.; Farlow, Martin R.; Quinn, Joseph F.; Kaye, Jeffrey A.; Leverenz, James B.; Tsuang, Debby W.; Yu, Chang-En; Peskind, Elaine R.

2013-01-01

Alzheimer’s disease (AD) is characterized by the presence in the brain of amyloid plaques, consisting predominately of the amyloid β peptide (Aβ), and neurofibrillary tangles, consisting primarily of tau. Hyper-phosphorylated-tau (p-tau) contributes to neuronal damage, and both p-tau and total-tau (t-tau) levels are elevated in AD cerebrospinal fluid (CSF) compared to cognitively normal controls. Our hypothesis was that increased ratios of CSF phosphorylated-tau levels relative to total-tau levels correlate with regulatory region genetic variation of kinase or phosphatase genes biologically associated with the phosphorylation status of tau. Eighteen SNPs located within 5′ and 3′ regions of 5 kinase and 4 phosphatase genes, as well as two SNPs within regulatory regions of the MAPT gene were chosen for this analysis. The study sample consisted of 101 AD patients and 169 cognitively normal controls. Rs7768046 in the FYN kinase gene and rs913275 in the PPP2R4 phosphatase gene were both associated with CSF p-tau and t-tau levels in AD. These SNPs were also differentially associated with either CSF t-tau (rs7768046) or CSF p-tau (rs913275) relative to t-tau levels in AD compared to controls. These results suggest that rs7768046 and rs913275 both influence CSF tau levels in an AD-associated manner. PMID:22927204

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils

PubMed Central

Banks, Rachel A.; Kim, Bumjin; Xu, Hong; Changolkar, Lakshmi; Leight, Susan N.; Riddle, Dawn M.; Li, Chi; Brown, Hannah J.; Zhang, Bin

2017-01-01

Neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau), and related disorders. Pathological tau proteins derived from human AD brains (AD-tau) act as proteopathic seeds that initiate the templated aggregation of soluble tau upon intracerebral injection into tau transgenic (Tg) and wild-type mice, thereby modeling human tau pathology. In this study, we found that aged Tg mice of both sexes expressing human tau proteins harboring a pathogenic P301L MAPT mutation labeled with green fluorescent protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentritic domain of neurons, but these mice did not develop de novo insoluble tau aggregates, which are characteristic of human AD and related tauopathies. However, intracerebral injections of either T40PL preformed fibrils (PFFs) or AD-tau seeds into T40PL-GFP mice induced abundant intraneuronal pathological inclusions of hyperphosphorylated T40PL-GFP. These injections of pathological tau resulted in the propagation of tau pathology from the injection site to neuroanatomically connected brain regions, and these tau inclusions consisted of both T40PL-GFP and WT endogenous mouse tau. Primary neurons cultured from the brains of neonatal T40PL-GFP mice provided an informative in vitro model for examining the uptake and localization of tau PFFs. These findings demonstrate the seeded aggregation of T40PL-GFP in vivo by synthetic PFFs and human AD-tau and the utility of this system to study the neuropathological spread of tau aggregates. SIGNIFICANCE STATEMENT The stereotypical spread of pathological tau protein aggregates have recently been attributed to the transmission of proteopathic seeds. Despite the extensive use of transgenic mouse models to investigate the propagation of tau pathology in vivo, details of the aggregation

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.

PubMed

Gibbons, Garrett S; Banks, Rachel A; Kim, Bumjin; Xu, Hong; Changolkar, Lakshmi; Leight, Susan N; Riddle, Dawn M; Li, Chi; Gathagan, Ronald J; Brown, Hannah J; Zhang, Bin; Trojanowski, John Q; Lee, Virginia M-Y

2017-11-22

Neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau), and related disorders. Pathological tau proteins derived from human AD brains (AD-tau) act as proteopathic seeds that initiate the templated aggregation of soluble tau upon intracerebral injection into tau transgenic (Tg) and wild-type mice, thereby modeling human tau pathology. In this study, we found that aged Tg mice of both sexes expressing human tau proteins harboring a pathogenic P301L MAPT mutation labeled with green fluorescent protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentritic domain of neurons, but these mice did not develop de novo insoluble tau aggregates, which are characteristic of human AD and related tauopathies. However, intracerebral injections of either T40PL preformed fibrils (PFFs) or AD-tau seeds into T40PL-GFP mice induced abundant intraneuronal pathological inclusions of hyperphosphorylated T40PL-GFP. These injections of pathological tau resulted in the propagation of tau pathology from the injection site to neuroanatomically connected brain regions, and these tau inclusions consisted of both T40PL-GFP and WT endogenous mouse tau. Primary neurons cultured from the brains of neonatal T40PL-GFP mice provided an informative in vitro model for examining the uptake and localization of tau PFFs. These findings demonstrate the seeded aggregation of T40PL-GFP in vivo by synthetic PFFs and human AD-tau and the utility of this system to study the neuropathological spread of tau aggregates. SIGNIFICANCE STATEMENT The stereotypical spread of pathological tau protein aggregates have recently been attributed to the transmission of proteopathic seeds. Despite the extensive use of transgenic mouse models to investigate the propagation of tau pathology in vivo , details of the aggregation

Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro.

PubMed

Pérez, Mar; Medina, Miguel; Hernández, Félix; Avila, Jesús

2018-03-05

The microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates. Increasing evidence in recent years supports the notion that Tau pathology spreading throughout the brain in AD and other Tauopathies is the consequence of the propagation of specific Tau species along neuroanatomically connected brain regions in a so-called "prion-like" manner. A number of steps are assumed to be involved in this process, including secretion, cellular uptake, transcellular transfer and/or seeding, although the precise mechanisms underlying propagation of Tau pathology are not fully understood yet. This review summarizes recent evidence on the nature of the specific Tau species that are propagated and the different mechanisms of Tau pathology spreading.

SHiP: a new facility to search for heavy neutrinos and study ντ properties

NASA Astrophysics Data System (ADS)

De Serio, M.; SHiP Collaboration

2016-05-01

SHiP (Search for Hidden Particles) is a newly designed fixed target facility, proposed at the CERN SPS accelerator, with the aim of complementing searches for New Physics at LHC by searching for light long-lived exotic particles with masses below a few GeV/c2. The sensitivity to Heavy Neutrinos will allow for the first time probing a region of the parameter space where Baryogenesis and active neutrino masses and oscillation could also be explained. A dedicated detector, based on OPERA-like bricks, will provide the first observation of the tau anti-neutrino. Moreover, ντ and ν¯τ cross-sections will be measured with a statistics 1000 times larger than currently available data and will allow extracting the F4 and F5 structure functions, never measured so far. Charm physics studies will be performed with significantly improved accuracy with respect to past experiments.

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice.

PubMed

Liu, Wencheng; Zhao, Lingzhi; Blackman, Brittany; Parmar, Mayur; Wong, Man Ying; Woo, Thomas; Yu, Fangmin; Chiuchiolo, Maria J; Sondhi, Dolan; Kaminsky, Stephen M; Crystal, Ronald G; Paul, Steven M

2016-12-07

Passive immunization with anti-tau monoclonal antibodies has been shown by several laboratories to reduce age-dependent tau pathology and neurodegeneration in mutant tau transgenic mice. These studies have used repeated high weekly doses of various tau antibodies administered systemically for several months and have reported reduced tau pathology of ∼40-50% in various brain regions. Here we show that direct intrahippocampal administration of the adeno-associated virus (AAV)-vectored anti-phospho-tau antibody PHF1 to P301S tau transgenic mice results in high and durable antibody expression, primarily in neurons. Hippocampal antibody levels achieved after AAV delivery were ∼50-fold more than those reported following repeated systemic administration. In contrast to systemic passive immunization, we observed markedly reduced (≥80-90%) hippocampal insoluble pathological tau species and neurofibrillary tangles following a single dose of AAV-vectored PHF1 compared with mice treated with an AAV-IgG control vector. Moreover, the hippocampal atrophy observed in untreated P301S mice was fully rescued by treatment with the AAV-vectored PHF1 antibody. Vectored passive immunotherapy with an anti-tau monoclonal antibody may represent a viable therapeutic strategy for treating or preventing such tauopathies as frontotemporal dementia, progressive supranuclear palsy, or Alzheimer's disease. We have used an adeno-associated viral (AAV) vector to deliver the genes encoding an anti-phospho-tau monoclonal antibody, PHF1, directly to the brain of mice that develop neurodegeneration due to a tau mutation that causes frontotemporal dementia (FTD). When administered systemically, PHF1 has been shown to modestly reduce tau pathology and neurodegeneration. Since such antibodies do not readily cross the blood-brain barrier, we used an AAV vector to deliver antibody directly to the hippocampus and observed much higher antibody levels and a much greater reduction in tau pathology. Using

Search for Neutrino Decay at SHALON

NASA Astrophysics Data System (ADS)

Sinitsyna, V. G.; Masip, M.; Nikolsky, S. I.; Sinitsyna, V. Y.

2012-08-01

The SHALON Cherenkov telescope has recorded over 2 × 106 extensive air showers during the past 17 years. The analysis of the signal at different zenith angles has included observations from the sub-horizontal direction Θ = 97°. This inclination defines an Earth skimming trajectory with 7 km of air and around 1000 km of rock in front of the telescope. During a period of 324 hours of observation, after a cut of shower-like events that may be caused by chaotic sky flashes or reflections on the snow of vertical showers, we have detected 5 air showers of TeV energies. We argue that these events may be caused by the decay of a long-lived penetrating particle entering the atmosphere from the ground and decaying in front of the telescope. We show that this particle can it not be a muon or a tau lepton. As a possible explanation, we discuss two scenarios with an unstable neutrino of mass m ≈ 0.5 GeV and cτ ≈ 30m. Remarkably, one of these models has been recently proposed to explain an excess of electron-like neutrino events at MiniBooNE.

Measurement of Muon Neutrino Disappearance with the NOvA Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vinton, Luke

The NOvA experiment consists of two functionally identical tracking calorimeter detectors which measure the neutrino energy and flavour composition of the NuMI beam at baselines of 1~km and 810~km. Measurements of neutrino oscillation parameters are extracted by comparing the neutrino energy spectrum in the far detector with predictions of the oscillated neutrino energy spectra that are made using information extracted from the near detector. Observation of muon neutrino disappearance allows NOvA to make measurements of the mass squared splittingmore » $$\\Delta m^2_{32}$$ and the mixing angle $$\\theta_{23}$$. The measurement of $$\\theta_{23}$$ will provide insight into the make-up of the third mass eigenstate and probe the muon-tau symmetry hypothesis that requires $$\\theta_{23} = \\pi/4$$. This thesis introduces three methods to improve the sensitivity of NOvA's muon neutrino disappearance analysis. First, neutrino events are separated according to an estimate of their energy resolution to distinguish well resolved events from events that are not so well resolved. Second, an optimised neutrino energy binning is implemented that uses finer binning in the region of maximum muon neutrino disappearance. Third, a hybrid selection is introduced that selects muon neutrino events with greater efficiency and purity. The combination of these improvements produces an increase in the sensitivity of the analysis equivalent to collecting 40-100\\% more data across the range of possible values of $$\\Delta m^2_{32}$$ and $$\\sin^2\\theta_{23}$$. This thesis presents new results using a 14~ktonne detector equivalent exposure of $$6.05\\times 10^{20}$$~protons~on~target. A fit to the far detector data, assuming normal hierarchy, produces $$\\Delta m^2_{32}=2.45^{+0.087}_{-0.079}\\times10^{-3}~\\text{eV}^2$$ and $$\\sin^2\\theta_{23}$$ in the range 0.429~-~0.593 with two statistically degenerate best fit points at 0.481 and 0.547. This measurement is consistent with maximal

Long baseline neutrino oscillation experiment at the AGS. Physics design report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beavis, D.; Carroll, A.; Chiang, I.

1995-04-01

The authors present a design for a multi-detector long baseline neutrino oscillation experiment at the BNL AGS. It has been approved by the BNL-HENP-PAC as AGS Experiment 889. The experiment will search for oscillations in the {nu}{sub {mu}}, disappearance channel and the {nu}{sub {mu}} {leftrightarrow} {nu}{sub e} appearance channel by means of four identical neutrino detectors located 1, 3, 24, and 68km from the AGS neutrino source. Observed depletion of the {nu}{sub {mu}} flux (via quasi-elastic muon neutrino events, {nu}{sub {mu}}n {yields} {mu}{sup {minus}}p) in the far detectors not attended by an observed proportional increase of the {nu}{sub e} fluxmore » (via quasi-elastic electron neutrino events, {nu}{sub e}n {yields} e{sup {minus}}p) in those detectors will be prima facie evidence for the oscillation channel {nu}{sub {mu}} {leftrightarrow} {nu}{sub {tau}}. The experiment is directed toward exploration of the region of the neutrino oscillation parameters {Delta}m{sup 2} and sin{sup 2}2{theta}, suggested by the Kamiokande and IMB deep underground detectors but it will also explore a region more than two orders of magnitude larger than that of previous accelerator experiments. The experiment will run in a mode new to BNL. It will receive the fast extracted proton beam on the neutrino target approximately 20 hours per day when the AGS is not filling RHIC. A key aspect of the experimental design involves placing the detectors 1.5 degrees off the center line of the neutrino beam, which has the important advantage that the central value of the neutrino energy ({approx} 1 GeV) and the beam spectral shape are, to a good approximation, the same in all four detectors. The proposed detectors are massive, imaging, water Cherenkov detectors similar in large part to the Kamiokande and IMB detectors. The design has profited from their decade-long experience, and from the detector designs of the forthcoming SNO and SuperKamiokande detectors.« less

A Search for supersymmetric Higgs bosons in the di-tau decay mode in p anti-p collisions at s**(1/2) = 1.8-TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Acosta, D.; Affolder, Anthony A.; Albrow, M.G.

2005-06-01

A search for direct production of Higgs bosons in the di-tau decay mode is performed with 86.3 {+-} 3.5 pb{sup -1} of data collected with the Collider Detector at Fermilab during the 1994-1995 data taking period of the Tevatron. We search for events where one tau decays to an electron plus neutrinos and the other tau decays hadronically. We perform a counting experiment and set limits on the cross section for supersymmetric Higgs boson production where tan {beta} is large and m{sub A} is small. For a benchmark parameter space point where m{sub A{sup 0}} = 100 GeV/c{sup 2} andmore » tan {beta} = 50, we limit the production cross section multiplied by the branching ratio to be less than 77.9 pb at the 95% confidence level compared to theoretically predicted value of 11.0 pb. This is the first search for Higgs bosons decaying to tau pairs at a hadron collider.« less

A tale of two modes: neutrino free-streaming in the early universe

NASA Astrophysics Data System (ADS)

Lancaster, Lachlan; Cyr-Racine, Francis-Yan; Knox, Lloyd; Pan, Zhen

2017-07-01

We present updated constraints on the free-streaming nature of cosmological neutrinos from cosmic microwave background (CMB) temperature and polarization power spectra, baryonic acoustic oscillation data, and distance ladder measurements of the Hubble constant. Specifically, we consider a Fermi-like four-fermion interaction between massless neutrinos, characterized by an effective coupling constant Geff, and resulting in a neutrino opacity dot tauνpropto Geff2 Tν5. Using a conservative flat prior on the parameter log10( Geff MeV2), we find a bimodal posterior distribution with two clearly separated regions of high probability. The first of these modes is consistent with the standard ΛCDM cosmology and corresponds to neutrinos decoupling at redshift zν,dec > 1.3×105, that is before the Fourier modes probed by the CMB damping tail enter the causal horizon. The other mode of the posterior, dubbed the "interacting neutrino mode", corresponds to neutrino decoupling occurring within a narrow redshift window centered around zν,dec~8300. This mode is characterized by a high value of the effective neutrino coupling constant, log10( Geff MeV2) = -1.72 ± 0.10 (68% C.L.), together with a lower value of the scalar spectral index and amplitude of fluctuations, and a higher value of the Hubble parameter. Using both a maximum likelihood analysis and the ratio of the two mode's Bayesian evidence, we find the interacting neutrino mode to be statistically disfavored compared to the standard ΛCDM cosmology, and determine this result to be largely driven by the low-l CMB temperature data. Interestingly, the addition of CMB polarization and direct Hubble constant measurements significantly raises the statistical significance of this secondary mode, indicating that new physics in the neutrino sector could help explain the difference between local measurements of H0, and those inferred from CMB data. A robust consequence of our results is that neutrinos must be free streaming long

Expanding the reach of heavy neutrino searches at the LHC

NASA Astrophysics Data System (ADS)

Flórez, Andrés; Gui, Kaiwen; Gurrola, Alfredo; Patiño, Carlos; Restrepo, Diego

2018-03-01

The observation of neutrino oscillations establishes that neutrinos have non-zero mass and provides one of the more compelling arguments for physics beyond the standard model (SM) of particle physics. We present a feasibility study to search for hypothetical Majorana neutrinos (N) with TeV scale masses, predicted by extensions of the SM to explain the small but non-zero SM neutrino mass, using vector boson fusion (VBF) processes at the 13 TeV LHC. In the context of the minimal Type-I seesaw mechanism (mTISM), the VBF production cross-section of a lepton (ℓ) and associated heavy Majorana neutrino (Nℓ) surpasses that of the Drell-Yan process at approximately mNℓ = 1.4TeV. We consider second and third-generation heavy neutrino (Nμ or Nτ, where ℓ= muon (μ) or tau (τ) leptons) production through VBF processes, with subsequent Nμ and Nτ decays to a lepton and two jets, as benchmark cases to show the effectiveness of the VBF topology for Nℓ searches at the 13 TeV LHC. The requirement of a dilepton pair combined with four jets, two of which are identified as VBF jets with large separation in pseudorapidity and a TeV scale dijet mass, is effective at reducing the SM background. These criteria may provide expected exclusion bounds, at 95% confidence level, of mNℓ < 1.7 (2.4) TeV, assuming 100 (1000) fb-1 of 13 TeV data from the LHC and mixing |VℓNℓ|2 = 1. The use of the VBF topology to search for mNℓ increases the discovery reach at the LHC, with expected significances greater than 5σ (3σ) for Nℓ masses up to 1.7 (2.05) TeV using 1000fb-1 of 13 TeV data from the LHC.

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology.

PubMed

Gratuze, Maud; Julien, Jacinthe; Petry, Franck R; Morin, Françoise; Planel, Emmanuel

2017-04-12

Abnormally hyperphosphorylated tau aggregated as intraneuronal neurofibrillary tangles is one of the two neuropathological hallmarks of Alzheimer's disease (AD). The majority of AD cases are sporadic with numerous environmental, biological and genetic risks factors. Interestingly, insulin dysfunction and hyperglycaemia are both risk factors for sporadic AD. However, how hyperglycaemia and insulin dysfunction affect tau pathology, is not well understood. In this study, we examined the effects of insulin deficiency on tau pathology in transgenic hTau mice by injecting different doses of streptozotocin (STZ), a toxin that destroys insulin-producing cells in the pancreas. One high dose of STZ resulted in marked diabetes, and five low doses led to a milder diabetes. Both groups exhibited brain tau hyperphosphorylation but no increased aggregation. Tau hyperphosphorylation correlated with inhibition of Protein Phosphatase 2A (PP2A), the main tau phosphatase. Interestingly, insulin injection 30 minutes before sacrifice partially restored tau phosphorylation to control levels in both STZ-injected groups. Our results confirm a link between insulin homeostasis and tau phosphorylation, which could explain, at least in part, a higher incidence of AD in diabetic patients.

Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption

PubMed Central

Jones, Emmalee M.; Dubey, Manish; Camp, Phillip J.; Vernon, Briana C.; Biernat, Jacek; Mandelkow, Eckhard; Majewski, Jaroslaw; Chi, Eva Y.

2012-01-01

The misfolding and aggregation of the intrinsically disordered, microtubule-associated tau protein into neurofibrillary tangles is implicated in the pathogenesis of Alzheimer's disease. However, the mechanisms of tau aggregation and toxicity remain unknown. Recent work has shown that lipid membrane can induce tau aggregation and that membrane permeabilization may serve as a pathway by which protein aggregates exert toxicity, suggesting that the plasma membrane may play dual roles in tau pathology. This prompted our investigation to assess tau's propensity to interact with membranes and to elucidate the mutually disruptive structural perturbations the interactions induce in both tau and the membrane. We show that although highly charged and soluble, the full-length tau (hTau40) is also highly surface active, selectively inserts into anionic DMPG lipid monolayers and induces membrane morphological changes. To resolve molecular-scale structural details of hTau40 associated with lipid membranes, X-ray and neutron scattering techniques are utilized. X-ray reflectivity indicates hTau40's presence underneath a DMPG monolayer and penetration into the lipid headgroups and tailgroups, whereas grazing incidence X-ray diffraction shows that hTau40 insertion disrupts lipid packing. Moreover, both air/water and DMPG lipid membrane interfaces induce the disordered hTau40 to partially adopt a more compact conformation with density similar to that of a folded protein. Neutron reflectivity shows that tau completely disrupts supported DMPG bilayers while leaving the neutral DPPC bilayer intact. Our results show that hTau40's strong interaction with anionic lipids induces tau structural compaction and membrane disruption, suggesting possible membrane-based mechanisms of tau aggregation and toxicity in neurodegenerative diseases. PMID:22401494

C P -invariance violation at short-baseline experiments in 3 +1 neutrino scenarios

NASA Astrophysics Data System (ADS)

de Gouvêa, André; Kelly, Kevin J.; Kobach, Andrew

2015-03-01

New neutrino degrees of freedom allow for more sources of charge parity- (C P ) invariance violation (CPV). We explore the requirements for accessing C P -odd mixing parameters in the so-called 3 +1 scenario, where one assumes the existence of one extra, mostly sterile neutrino degree of freedom, heavier than the other three mass eigenstates. As a first step, we concentrate on the νe→νμ appearance channel in a hypothetical, upgraded version of the ν STORM proposal. We establish that the optimal baseline for CPV studies depends strongly on the value of Δ m142—the new mass-squared difference—and that the ability to observe CPV depends significantly on whether the experiment is performed at the optimal baseline. Even at the optimal baseline, it is very challenging to see CPV in 3 +1 scenarios if one considers only one appearance channel. Full exploration of CPV in short-baseline experiments will require precision measurements of tau appearance, a challenge significantly beyond what is currently being explored by the experimental neutrino community.

Neutrino Oscillations and the Sudbury Neutrino Observatory

NASA Astrophysics Data System (ADS)

Wark, David

2001-04-01

When the existence of the neutrino was almost apologetically first proposed by Wolfgang Pauli it was intended to explain the mysterious apparent absence of energy and momentum in beta decay. 70 years later the neutrino has indeed solved that mystery, but it has generated still more of its own. Are neutrinos massive? Is it possible to create a neutrino with its spin in the same direction as its momentum? What fraction of the mass of the Universe is made up of neutrinos? Are the flavour labels which we put on neutrinos, like electron and muon, really fixed or can they change? Why does no experiment see the predicted flux of neutrinos from the Sun? Why do there appear to be roughly equal numbers of muon and electron neutrinos created in our atmosphere, rather than the 2:1 ratio we would expect? Many of these questions were coupled when Bruno Pontecorvo first suggested that the shortfall in solar neutrino measurements were caused by neutrino oscillations - neutrinos spontaneously changing flavour as they travel from the Sun. 30 years later we still await definitive proof of that conjecture, and providing that proof is the reason for the Sudbury Neutrino Observatory. The talk will discuss the current state of neutrino oscillations studies, and show how the unique capabilities of the Sudbury Neutrino Observatory can provide definitive proof of whether neutrino oscillations are the long-sought answer to the solar neutrino problem.

Search for tau-neutrino interactions in the BEBC beam dump experiment

NASA Astrophysics Data System (ADS)

Talebzadeh, M.; Guy, J.; Venus, W.; Aderholz, M.; Barnham, K. W. J.; Bostock, P.; Clayton, E. F.; Cooper-Sarkar, A. M.; Faccini-Turluer, M. L.; Grässler, H.; Hultquist, K.; Hulth, P. O.; Kreutzmann, H.; Krstic, J.; Miller, D. B.; Mobayyen, M. M.; Myatt, G.; Nellen, B.; Parker, M. A.; Schmitz, N.; Sewell, S.; Simopoulou, E.; Vayaki, A.; Vignaud, D.; Wachsmuth, H.; Wittek, W.; Wünsch, B.; BEBC WA66 Collaboration

A novel and efficient kinematic method is used to estimate the number of ντ charged current interactions with Eν > 20 GeV in the BEBC beam dump experiment. The result, -14±12 ντ events, is consistent with zero. The ratio of D s to D meson production in 400 GeV proton interactions in copper is estimated to be below 0.65 at 90% c.l. The oscillation probability P( νe→ ντ) averaged over the electron-(anti)neutrino spectrum is found to be below 18%. The hypothesis that νe and ντ are identical is excluded by about 6 standard deviations. A remarkable event is described: it contains a muon, a high pT photon and a high pT hadron.

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

PubMed Central

Boluda, Susana; Iba, Michiyo; Zhang, Bin; Raible, Kevin M.; Lee, Virginia M-Y.; Trojanowski, John Q.

2015-01-01

Filamentous tau pathologies are hallmark lesions of several neurodegenerative tauopathies including Alzheimer’s disease (AD) and corticobasal degeneration (CBD) which show cell type-specific and topographically distinct tau inclusions. Growing evidence supports templated transmission of tauopathies through functionally interconnected neuroanatomical pathways suggesting that different self-propagating strains of pathological tau could account for the diverse manifestations of neurodegenerative tauopathies. Here, we describe the rapid and distinct cell type-specific spread of pathological tau following intracerebral injections of CBD or AD brain extracts enriched in pathological tau (designated CBD-Tau and AD-Tau, respectively) in young human mutant P301S tau transgenic (Tg) mice (line PS19) ~6–9 months before they show onset of mutant tau transgene-induced tau pathology. At 1 month post-injection of CBD-Tau, tau inclusions developed predominantly in oligodendrocytes of the fimbria and white matter near the injection sites with infrequent intraneuronal tau aggregates. In contrast, injections of AD-Tau in young PS19 mice induced tau pathology predominantly in neuronal perikarya with little or no oligodendrocyte involvement 1 month post-injection. With longer post-injection survival intervals of up to 6 months, CBD-Tau- and AD-Tau-induced tau pathology spread to different brain regions distant from the injection sites while maintaining the cell type-specific pattern noted above. Finally, CA3 neuron loss was detected 3 months post-injection of AD-Tau but not CBD-Tau. Thus, AD-Tau and CBD-Tau represent specific pathological tau strains that spread differentially and may underlie distinct clinical and pathological features of these two tauopathies. Hence, these strains could become targets to develop disease-modifying therapies for CBD and AD. PMID:25534024

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis.

PubMed

Hu, Wen; Wu, Feng; Zhang, Yanchong; Gong, Cheng-Xin; Iqbal, Khalid; Liu, Fei

2017-01-01

Microtubule-associated protein tau is hyperphosphorylated and aggregated in affected neurons in Alzheimer disease (AD) brains. The tau pathology starts from the entorhinal cortex (EC), spreads to the hippocampus and frontal and temporal cortices, and finally to all isocortex areas, but the cerebellum is spared from tau lesions. The molecular basis of differential vulnerability of different brain regions to tau pathology is not understood. In the present study, we analyzed brain regional expressions of tau and tau pathology-related proteins. We found that tau was hyperphosphorylated at multiple sites in the frontal cortex (FC), but not in the cerebellum, from AD brain. The level of tau expression in the cerebellum was about 1/4 of that seen in the frontal and temporal cortices in human brain. In the rat brain, the expression level of tau with three microtubule-binding repeats (3R-tau) was comparable in the hippocampus, EC, FC, parietal-temporal cortex (PTC), occipital-temporal cortex (OTC), striatum, thalamus, olfactory bulb (OB) and cerebellum. However, the expression level of 4R-tau was the highest in the EC and the lowest in the cerebellum. Tau phosphatases, kinases, microtubule-related proteins and other tau pathology-related proteins were also expressed in a region-specific manner in the rat brain. These results suggest that higher levels of tau and tau kinases in the EC and low levels of these proteins in the cerebellum may accounts for the vulnerability and resistance of these representative brain regions to the development of tau pathology, respectively. The present study provides the regional expression profiles of tau and tau pathology-related proteins in the brain, which may help understand the brain regional vulnerability to tau pathology in neurodegenerative tauopathies.

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.

PubMed

Nobuhara, Chloe K; DeVos, Sarah L; Commins, Caitlin; Wegmann, Susanne; Moore, Benjamin D; Roe, Allyson D; Costantino, Isabel; Frosch, Matthew P; Pitstick, Rose; Carlson, George A; Hock, Christoph; Nitsch, Roger M; Montrasio, Fabio; Grimm, Jan; Cheung, Anne E; Dunah, Anthone W; Wittmann, Marion; Bussiere, Thierry; Weinreb, Paul H; Hyman, Bradley T; Takeda, Shuko

2017-06-01

The clinical progression of Alzheimer disease (AD) is associated with the accumulation of tau neurofibrillary tangles, which may spread throughout the cortex by interneuronal tau transfer. If so, targeting extracellular tau species may slow the spreading of tau pathology and possibly cognitive decline. To identify suitable target epitopes, we tested the effects of a panel of tau antibodies on neuronal uptake and aggregation in vitro. Immunodepletion was performed on brain extract from tau-transgenic mice and postmortem AD brain and added to a sensitive fluorescence resonance energy transfer-based tau uptake assay to assess blocking efficacy. The antibodies reduced tau uptake in an epitope-dependent manner: N-terminal (Tau13) and middomain (6C5 and HT7) antibodies successfully prevented uptake of tau species, whereas the distal C-terminal-specific antibody (Tau46) had little effect. Phosphorylation-dependent (40E8 and p396) and C-terminal half (4E4) tau antibodies also reduced tau uptake despite removing less total tau by immunodepletion, suggesting specific interactions with species involved in uptake. Among the seven antibodies evaluated, 6C5 most efficiently blocked uptake and subsequent aggregation. More important, 6C5 also blocked neuron-to-neuron spreading of tau in a unique three-chamber microfluidic device. Furthermore, 6C5 slowed down the progression of tau aggregation even after uptake had begun. Our results imply that not all antibodies/epitopes are equally robust in terms of blocking tau uptake of human AD-derived tau species. Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology

PubMed Central

Gratuze, Maud; Julien, Jacinthe; Petry, Franck R.; Morin, Françoise; Planel, Emmanuel

2017-01-01

Abnormally hyperphosphorylated tau aggregated as intraneuronal neurofibrillary tangles is one of the two neuropathological hallmarks of Alzheimer’s disease (AD). The majority of AD cases are sporadic with numerous environmental, biological and genetic risks factors. Interestingly, insulin dysfunction and hyperglycaemia are both risk factors for sporadic AD. However, how hyperglycaemia and insulin dysfunction affect tau pathology, is not well understood. In this study, we examined the effects of insulin deficiency on tau pathology in transgenic hTau mice by injecting different doses of streptozotocin (STZ), a toxin that destroys insulin-producing cells in the pancreas. One high dose of STZ resulted in marked diabetes, and five low doses led to a milder diabetes. Both groups exhibited brain tau hyperphosphorylation but no increased aggregation. Tau hyperphosphorylation correlated with inhibition of Protein Phosphatase 2A (PP2A), the main tau phosphatase. Interestingly, insulin injection 30 minutes before sacrifice partially restored tau phosphorylation to control levels in both STZ-injected groups. Our results confirm a link between insulin homeostasis and tau phosphorylation, which could explain, at least in part, a higher incidence of AD in diabetic patients. PMID:28402338

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

PubMed Central

Maphis, Nicole; Xu, Guixiang; Kokiko-Cochran, Olga N.; Jiang, Shanya; Cardona, Astrid; Ransohoff, Richard M.; Lamb, Bruce T.

2015-01-01

Pathological aggregation of tau is a hallmark of Alzheimer’s disease and related tauopathies. We have previously shown that the deficiency of the microglial fractalkine receptor (CX3CR1) led to the acceleration of tau pathology and memory impairment in an hTau mouse model of tauopathy. Here, we show that microglia drive tau pathology in a cell-autonomous manner. First, tau hyperphosphorylation and aggregation occur as early as 2 months of age in hTauCx3cr1−/− mice. Second, CD45+ microglial activation correlates with the spatial memory deficit and spread of tau pathology in the anatomically connected regions of the hippocampus. Third, adoptive transfer of purified microglia derived from hTauCx3cr1−/− mice induces tau hyperphosphorylation within the brains of non-transgenic recipient mice. Finally, inclusion of interleukin 1 receptor antagonist (Kineret®) in the adoptive transfer inoculum significantly reduces microglia-induced tau pathology. Together, our results suggest that reactive microglia are sufficient to drive tau pathology and correlate with the spread of pathological tau in the brain. PMID:25833819

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.

PubMed

Song, Lixin; Lu, Sherry X; Ouyang, Xuesong; Melchor, Jerry; Lee, Julie; Terracina, Giuseppe; Wang, Xiaohai; Hyde, Lynn; Hess, J Fred; Parker, Eric M; Zhang, Lili

2015-03-26

Microtubule associated protein tau is the major component of the neurofibrillary tangles (NFTs) found in the brains of patients with Alzheimer's disease and several other neurodegenerative diseases. Tau mutations are associated with frontotemperal dementia with parkinsonism on chromosome 17 (FTDP-17). rTg4510 mice overexpress human tau carrying the P301L FTDP-17 mutation and develop robust NFT-like pathology at 4-5 months of age. The current study is aimed at characterizing the rTg4510 mice to better understand the genesis of tau pathology and to better enable the use of this model in drug discovery efforts targeting tau pathology. Using a panel of immunoassays, we analyzed the age-dependent formation of pathological tau in rTg4510 mice and our data revealed a steady age-dependent accumulation of pathological tau in the insoluble fraction of brain homogenates. The pathological tau was associated with multiple post-translational modifications including aggregation, phosphorylation at a wide variety of sites, acetylation, ubiquitination and nitration. The change of most tau species reached statistical significance at the age of 16 weeks. There was a strong correlation between the different post-translationally modified tau species in this heterogeneous pool of pathological tau. Total tau in the cerebrospinal fluid (CSF) displayed a multiphasic temporal profile distinct from the steady accumulation of pathological tau in the brain. Female rTg4510 mice displayed significantly more aggressive accumulation of pathological tau in the brain and elevation of total tau in CSF than their male littermates. The immunoassays described here were used to generate the most comprehensive description of the changes in various tau species across the lifespan of the rTg4510 mouse model. The data indicate that development of tauopathy in rTg4510 mice involves the accumulation of a pool of pathological tau that carries multiple post-translational modifications, a process that can be

Effective Majorana mass matrix from tau and pseudoscalar meson lepton number violating decays

NASA Astrophysics Data System (ADS)

Abada, Asmaa; De Romeri, Valentina; Lucente, Michele; Teixeira, Ana M.; Toma, Takashi

2018-02-01

An observation of any lepton number violating process will undoubtedly point towards the existence of new physics and indirectly to the clear Majorana nature of the exchanged fermion. In this work, we explore the potential of a minimal extension of the Standard Model via heavy sterile fermions with masses in the [0.1 - 10] GeV range concerning an extensive array of "neutrinoless" meson and tau decay processes. We assume that the Majorana neutrinos are produced on-shell, and focus on three-body decays. We conduct an update on the bounds on the active-sterile mixing elements, |{U}_{ℓ }{{}{_{α}}}_4{U}_{ℓ }{{}{_{β}}}_4| , taking into account the most recent experimental bounds (and constraints) and new theoretical inputs, as well as the effects of a finite detector, imposing that the heavy neutrino decay within the detector. This allows to establish up-to-date comprehensive constraints on the sterile fermion parameter space. Our results suggest that the branching fractions of several decays are close to current sensitivities (likely within reach of future facilities), some being already in conflict with current data (as is the case of K + → ℓ α + ℓ β + π -, and τ - → μ +π-π-). We use these processes to extract constraints on all entries of an enlarged definition of a 3 × 3 "effective" Majorana neutrino mass matrix m ν αβ .

Neutrino masses, neutrino oscillations, and cosmological implications

NASA Technical Reports Server (NTRS)

Stecker, F. W.

1982-01-01

Theoretical concepts and motivations for considering neutrinos having finite masses are discussed and the experimental situation on searches for neutrino masses and oscillations is summarized. The solar neutrino problem, reactor, deep mine and accelerator data, tri decay experiments and double beta-decay data are considered and cosmological implications and astrophysical data relating to neutrino masses are reviewed. The neutrino oscillation solution to the solar neutrino problem, the missing mass problem in galaxy halos and galaxy cluster galaxy formation and clustering, and radiative neutrino decay and the cosmic ultraviolet background radiation are examined.

DOPA Decarboxylase Modulates Tau Toxicity.

PubMed

Kow, Rebecca L; Sikkema, Carl; Wheeler, Jeanna M; Wilkinson, Charles W; Kraemer, Brian C

2018-03-01

The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D 2 -family dopamine receptors ameliorated tauopathy in multiple models including a Caenorhabditis elegans model of tauopathy. To better understand how loss of D 2 -family dopamine receptors can ameliorate tau toxicity, we screened a collection of C. elegans mutations in dopamine-related genes (n = 45) for changes in tau transgene-induced behavioral defects. These included many genes responsible for dopamine synthesis, metabolism, and signaling downstream of the D 2 receptors. We identified one dopamine synthesis gene, DOPA decarboxylase (DDC), as a suppressor of tau toxicity in tau transgenic worms. Loss of the C. elegans DDC gene, bas-1, ameliorated the behavioral deficits of tau transgenic worms, reduced phosphorylated and detergent-insoluble tau accumulation, and reduced tau-mediated neuron loss. Loss of function in other genes in the dopamine and serotonin synthesis pathways did not alter tau-induced toxicity; however, their function is required for the suppression of tau toxicity by bas-1. Additional loss of D 2 -family dopamine receptors did not synergize with bas-1 suppression of tauopathy phenotypes. Loss of the DDC bas-1 reduced tau-induced toxicity in a C. elegans model of tauopathy, while loss of no other dopamine or serotonin synthesis genes tested had this effect. Because loss of activity upstream of DDC could reduce suppression of tau by DDC, this suggests the possibility that loss of DDC suppresses tau via the combined accumulation of dopamine precursor levodopa and serotonin precursor 5-hydroxytryptophan. Published by Elsevier Inc.

Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation.

PubMed

Wei, Yu-Ping; Ye, Jin-Wang; Wang, Xiong; Zhu, Li-Ping; Hu, Qing-Hua; Wang, Qun; Ke, Dan; Tian, Qing; Wang, Jian-Zhi

2018-04-01

Hyperphosphorylated tau is the major protein component of neurofibrillary tangles in the brains of patients with Alzheimer's disease (AD). However, the mechanism underlying tau hyperphosphorylation is not fully understood. Here, we demonstrated that exogenously expressed wild-type human tau40 was detectable in the phosphorylated form at multiple AD-associated sites in cytoplasmic and nuclear fractions from HEK293 cells. Among these sites, tau phosphorylated at Thr205 and Ser214 was almost exclusively found in the nuclear fraction at the conditions used in the present study. With the intracellular tau accumulation, the Ca 2+ concentration was significantly increased in both cytoplasmic and nuclear fractions. Further studies using site-specific mutagenesis and pharmacological treatment demonstrated that phosphorylation of tau at Thr205 increased nuclear Ca 2+ concentration with a simultaneous increase in the phosphorylation of Ca 2+ /calmodulin-dependent protein kinase IV (CaMKIV) at Ser196. On the other hand, phosphorylation of tau at Ser214 did not significantly change the nuclear Ca 2+ /CaMKIV signaling. Finally, expressing calmodulin-binding protein-4 that disrupts formation of the Ca 2+ /calmodulin complex abolished the okadaic acid-induced tau hyperphosphorylation in the nuclear fraction. We conclude that the intracellular accumulation of phosphorylated tau, as detected in the brains of AD patients, can trigger nuclear Ca 2+ /CaMKIV signaling, which in turn aggravates tau hyperphosphorylation. Our findings provide new insights for tauopathies: hyperphosphorylation of intracellular tau and an increased Ca 2+ concentration may induce a self-perpetuating harmful loop to promote neurodegeneration.

Collective neutrino oscillations and neutrino wave packets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akhmedov, Evgeny; Lindner, Manfred; Kopp, Joachim, E-mail: akhmedov@mpi-hd.mpg.de, E-mail: jkopp@uni-mainz.de, E-mail: lindner@mpi-hd.mpg.de

Effects of decoherence by wave packet separation on collective neutrino oscillations in dense neutrino gases are considered. We estimate the length of the wave packets of neutrinos produced in core collapse supernovae and the expected neutrino coherence length, and then proceed to consider the decoherence effects within the density matrix formalism of neutrino flavour transitions. First, we demonstrate that for neutrino oscillations in vacuum the decoherence effects are described by a damping term in the equation of motion of the density matrix of a neutrino as a whole (as contrasted to that of the fixed-momentum components of the neutrino densitymore » matrix). Next, we consider neutrino oscillations in ordinary matter and dense neutrino backgrounds, both in the adiabatic and non-adiabatic regimes. In the latter case we study two specific models of adiabaticity violation—one with short-term and another with extended non-adiabaticity. It is demonstrated that, while in the adiabatic case a damping term is present in the equation of motion of the neutrino density matrix (just like in the vacuum oscillation case), no such term in general appears in the non-adiabatic regime.« less

Solar neutrino detectors as sterile neutrino hunters

NASA Astrophysics Data System (ADS)

Pallavicini, Marco; Borexino-SOX Collaboration; Agostini, M.; Altenmüller, K.; Appel, S.; Atroshchenko, V.; Bellini, G.; Benziger, J.; Berton, N.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Carlini, M.; Cavalcante, P.; Chepurnov, A.; Choi, K.; Cloué, O.; Cribier, M.; D'Angelo, D.; Davini, S.; Derbin, A.; Di Noto, L.; Drachnev, I.; Durero, M.; Etenko, A.; Farinon, S.; Fischer, V.; Fomenko, K.; Franco, D.; Gabriele, F.; Gaffiot, J.; Galbiati, C.; Gschwender, M.; Ghiano, C.; Giammarchi, M.; Goeger-Neff, M.; Goretti, A.; Gromov, M.; Hagner, C.; Houdy, Th.; Hungerford, E.; Ianni, Aldo; Ianni, Andrea; Jany, A.; Jedrzejczak, K.; Jeschke, D.; Jonquères, N.; Kobychev, V.; Korablev, D.; Korga, G.; Kornoukhov, V.; Kryn, D.; Lachenmaier, T.; Lasserre, T.; Laubenstein, M.; Lehnert, B.; Link, J.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, I.; Manecki, S.; Maneschg, W.; Marcocci, S.; Maricic, J.; Mention, G.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Montuschi, M.; Mosteiro, P.; Muratova, V.; Musenich, R.; Neumair, B.; Oberauer, L.; Ortica, F.; Papp, L.; Pocar, A.; Ranucci, G.; Razeto, A.; Re, A.; Reinert, Y.; Romani, A.; Roncin, R.; Rossi, N.; Schönert, S.; Scola, L.; Semenov, D.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Thurn, J.; Toropova, M.; Unzhakov, E.; Veyssière, C.; Vishneva, A.; Vivier, M.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Weinz, S.; Winter, J.; Wojcik, M.; Wurm, M.; Yokley, Z.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.

2017-09-01

The large size and the very low radioactive background of solar neutrino detectors such as Borexino at the Gran Sasso Laboratory in Italy offer a unique opportunity to probe the existence of neutrino oscillations into new sterile components by means of carefully designed and well calibrated anti-neutrino and neutrino artificial sources. In this paper we briefly summarise the key elements of the SOX experiment, a program for the search of sterile neutrinos (and other short distance effects) by means of a 144Ce-144Pr anti-neutrino source and, possibly in the medium term future, with a 51Cr neutrino source.

Search for the lepton-flavor-violating leptonic B(0)-->mu(+/-)tau(-/+) and B(0)-->e(+/-)tau(-/+).

PubMed

Bornheim, A; Lipeles, E; Pappas, S P; Weinstein, A J; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Rosner, J L; Ryd, A; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Sun, W M; Thayer, J G; Urner, D; Wilksen, T; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Wiss, J; Edwards, K W; Besson, D; Gao, K Y; Gong, D T; Kubota, Y; Li, S Z; Poling, R; Scott, A W; Smith, A; Stepaniak, C J; Urheim, J; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Arms, K; Gan, K K; Severini, H; Skubic, P; Asner, D M; Dytman, S A; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shibata, E I; Shipsey, I P J; Adams, G S; Chasse, M; Cummings, J P; Danko, I; Napolitano, J; Cronin-Hennessy, D; Park, C S; Park, W; Thayer, J B; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Stroynowski, R; Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dambasuren, E; Dorjkhaidav, O; Menaa, N; Mountain, R; Muramatsu, H; Nandakumar, R; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Mahmood, A H; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M

2004-12-10

We have searched a sample of 9.6 x 10(6) BB events for the lepton-flavor-violating leptonic B decays, B(0)-->mu(+/-)tau(-/+) and B(0)-->e(+/-)tau(-/+). The tau lepton was detected through the decay modes tau-->lnunu(-) , where l=e, mu. There is no indication of a signal, and we obtain the 90% confidence level upper limits B(B(0)-->mu(+/-)tau(-/+))<3.8 x 10(-5) and B(B(0)-->e(+/-)tau(-/+))<1.3 x 10(-4).

Tau Kung | NREL

Science.gov Websites

Tau Kung Photo of Feitau Kung Tau Kung Commercial Buildings Research Engineer Feitau.Kung@nrel.gov evaluating building system energy performance in commercial settings, such as office, healthcare, higher

Prospect for measuring the CP phase in the $$h\\tau\\tau$$ coupling at the LHC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Askew, Andrew; Jaiswal, Prerit; Okui, Takemichi

The search for a new source of CP violation is one of the most important endeavors in particle physics. A particularly interesting way to perform this search is to probe the CP phase in themore » $$h\\tau\\tau$$ coupling, as the phase is currently completely unconstrained by all existing data. Recently, a novel variable $$\\Theta$$ was proposed for measuring the CP phase in the $$h\\tau\\tau$$ coupling through the $$\\tau^\\pm \\to \\pi^\\pm \\pi^0 \

Prospect for measuring the CP phase in the $$h\\tau\\tau$$ coupling at the LHC

DOE PAGES

Askew, Andrew; Jaiswal, Prerit; Okui, Takemichi; ...

2015-04-01

The search for a new source of CP violation is one of the most important endeavors in particle physics. A particularly interesting way to perform this search is to probe the CP phase in themore » $$h\\tau\\tau$$ coupling, as the phase is currently completely unconstrained by all existing data. Recently, a novel variable $$\\Theta$$ was proposed for measuring the CP phase in the $$h\\tau\\tau$$ coupling through the $$\\tau^\\pm \\to \\pi^\\pm \\pi^0 \

Physics of neutrino flavor transformation through matter-neutrino resonances

NASA Astrophysics Data System (ADS)

Wu, Meng-Ru; Duan, Huaiyu; Qian, Yong-Zhong

2016-01-01

In astrophysical environments such as core-collapse supernovae and neutron star-neutron star or neutron star-black hole mergers where dense neutrino media are present, matter-neutrino resonances (MNRs) can occur when the neutrino propagation potentials due to neutrino-electron and neutrino-neutrino forward scattering nearly cancel each other. We show that neutrino flavor transformation through MNRs can be explained by multiple adiabatic solutions similar to the Mikheyev-Smirnov-Wolfenstein mechanism. We find that for the normal neutrino mass hierarchy, neutrino flavor evolution through MNRs can be sensitive to the shape of neutrino spectra and the adiabaticity of the system, but such sensitivity is absent for the inverted hierarchy.

An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

PubMed Central

Cavallini, Annalisa; Brewerton, Suzanne; Bell, Amanda; Sargent, Samantha; Glover, Sarah; Hardy, Clare; Moore, Roger; Calley, John; Ramachandran, Devaki; Poidinger, Michael; Karran, Eric; Davies, Peter; Hutton, Michael; Szekeres, Philip; Bose, Suchira

2013-01-01

Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia. Identifying the kinases involved in the pathological phosphorylation of tau may identify novel targets for AD. We used an unbiased approach to study the effect of 352 human kinases on their ability to phosphorylate tau at epitopes associated with AD. The kinases were overexpressed together with the longest form of human tau in human neuroblastoma cells. Levels of total and phosphorylated tau (epitopes Ser(P)-202, Thr(P)-231, Ser(P)-235, and Ser(P)-396/404) were measured in cell lysates using AlphaScreen assays. GSK3α, GSK3β, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes. We further dissected the effects of GSK3α and GSK3β using pharmacological and genetic tools in hTau primary cortical neurons. Pathway analysis of the kinases identified in the screen suggested mechanisms for regulation of total tau levels and tau phosphorylation; for example, kinases that affect total tau levels do so by inhibition or activation of translation. A network fishing approach with the kinase hits identified other key molecules putatively involved in tau phosphorylation pathways, including the G-protein signaling through the Ras family of GTPases (MAPK family) pathway. The findings identify novel tau kinases and novel pathways that may be relevant for AD and other tauopathies. PMID:23798682

Structure-based inhibitors of tau aggregation

NASA Astrophysics Data System (ADS)

Seidler, P. M.; Boyer, D. R.; Rodriguez, J. A.; Sawaya, M. R.; Cascio, D.; Murray, K.; Gonen, T.; Eisenberg, D. S.

2018-02-01

Aggregated tau protein is associated with over 20 neurological disorders, which include Alzheimer's disease. Previous work has shown that tau's sequence segments VQIINK and VQIVYK drive its aggregation, but inhibitors based on the structure of the VQIVYK segment only partially inhibit full-length tau aggregation and are ineffective at inhibiting seeding by full-length fibrils. Here we show that the VQIINK segment is the more powerful driver of tau aggregation. Two structures of this segment determined by the cryo-electron microscopy method micro-electron diffraction explain its dominant influence on tau aggregation. Of practical significance, the structures lead to the design of inhibitors that not only inhibit tau aggregation but also inhibit the ability of exogenous full-length tau fibrils to seed intracellular tau in HEK293 biosensor cells into amyloid. We also raise the possibility that the two VQIINK structures represent amyloid polymorphs of tau that may account for a subset of prion-like strains of tau.

Sources of extracellular tau and its signaling.

PubMed

Avila, Jesús; Simón, Diana; Díaz-Hernández, Miguel; Pintor, Jesús; Hernández, Félix

2014-01-01

The pathology associated with tau protein, tauopathy, has been recently analyzed in different disorders, leading to the suggestion that intracellular and extracellular tau may itself be the principal agent in the transmission and spreading of tauopathies. Tau pathology is based on an increase in the amount of tau, an increase in phosphorylated tau, and/or an increase in aggregated tau. Indeed, phosphorylated tau protein is the main component of tau aggregates, such as the neurofibrillary tangles present in the brain of Alzheimer's disease patients. It has been suggested that intracellular tau could be toxic to neurons in its phosphorylated and/or aggregated form. However, extracellular tau could also damage neurons and since neuronal death is widespread in Alzheimer's disease, mainly among cholinergic neurons, these cells may represent a possible source of extracellular tau. However, other sources of extracellular tau have been proposed that are independent of cell death. In addition, several ways have been proposed for cells to interact with, transmit, and spread extracellular tau, and to transduce signals mediated by this tau. In this work, we will discuss the role of extracellular tau in the spreading of the tau pathology.

Effects of antibodies to phosphorylated and non-phosphorylated tau on in vitro tau phosphorylation at Serine-199: Preliminary report.

PubMed

Loeffler, David A; Smith, Lynnae M; Klaver, Andrea C; Martić, Sanela

2015-07-01

Phosphorylation of multiple amino acids on tau protein ("hyperphosphorylation") is required for the development of tau pathology in Alzheimer's disease. Administration of anti-tau antibodies to transgenic "tauopathy mice" has been shown to reduce their tau pathology but the mechanisms responsible are unclear. To examine the effects of anti-tau antibodies on tau phosphorylation, we used western blots to study the effects of three antibodies to phosphorylated tau (pTau), namely anti-pTau S199, T231, and S396, and three antibodies to non-phosphorylated tau on in vitro phosphorylation of recombinant human tau-441 at S199. Inclusion of an anti-pTau T231 antibody in the phosphorylation reaction reduced the intensity of monomeric pTau S199 in western blots of denaturing gels, but the other antibodies had no apparent effects on this process. Surprisingly, including all three anti-phospho-tau antibodies in the reaction did not reduce the intensity of the monomer band, possibly due to steric hindrance between the antibodies. These preliminary findings suggest that anti-tau antibodies may have minimal direct effects on tau phosphorylation. Limitations of using western blots to examine the effects of anti-tau antibodies on this process were found to include between-experiment variability in pTau band densities and poor resolution of high molecular weight pTau oligomers. The presence of bands representing immunoglobulins as well as pTau may also complicate interpretation of the western blots. Further studies are indicated to examine the effects of anti-pTau antibodies on phosphorylation of other tau amino acids in addition to S199. Copyright © 2015 Elsevier Inc. All rights reserved.

Plasma tau in Alzheimer disease.

PubMed

Mattsson, Niklas; Zetterberg, Henrik; Janelidze, Shorena; Insel, Philip S; Andreasson, Ulf; Stomrud, Erik; Palmqvist, Sebastian; Baker, David; Tan Hehir, Cristina A; Jeromin, Andreas; Hanlon, David; Song, Linan; Shaw, Leslie M; Trojanowski, John Q; Weiner, Michael W; Hansson, Oskar; Blennow, Kaj

2016-10-25

To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related to changes in cognition, CSF biomarkers of AD pathology (including β-amyloid [Aβ] and tau), brain atrophy, and brain metabolism. This was a study of plasma tau in prospectively followed patients with AD (n = 179), patients with mild cognitive impairment (n = 195), and cognitive healthy controls (n = 189) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and cross-sectionally studied patients with AD (n = 61), mild cognitive impairment (n = 212), and subjective cognitive decline (n = 174) and controls (n = 274) from the Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study at Lund University, Sweden. A total of 1284 participants were studied. Associations were tested between plasma tau and diagnosis, CSF biomarkers, MRI measures, 18 fluorodeoxyglucose-PET, and cognition. Higher plasma tau was associated with AD dementia, higher CSF tau, and lower CSF Aβ 42 , but the correlations were weak and differed between ADNI and BioFINDER. Longitudinal analysis in ADNI showed significant associations between plasma tau and worse cognition, more atrophy, and more hypometabolism during follow-up. Plasma tau partly reflects AD pathology, but the overlap between normal aging and AD is large, especially in patients without dementia. Despite group-level differences, these results do not support plasma tau as an AD biomarker in individual people. Future studies may test longitudinal plasma tau measurements in AD. © 2016 American Academy of Neurology.

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

PubMed Central

Iijima-Ando, Kanae; Sekiya, Michiko; Suzuki, Emiko; Lu, Bingwei; Iijima, Koichi M.

2012-01-01

Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions trigger tau abnormality in AD is not fully understood. A reduction in the number of mitochondria in the axon has been implicated in AD. In this study, we investigated whether and how loss of axonal mitochondria promotes tau phosphorylation and toxicity in vivo. Using transgenic Drosophila expressing human tau, we found that RNAi–mediated knockdown of milton or Miro, an adaptor protein essential for axonal transport of mitochondria, enhanced human tau-induced neurodegeneration. Tau phosphorylation at an AD–related site Ser262 increased with knockdown of milton or Miro; and partitioning defective-1 (PAR-1), the Drosophila homolog of mammalian microtubule affinity-regulating kinase, mediated this increase of tau phosphorylation. Tau phosphorylation at Ser262 has been reported to promote tau detachment from microtubules, and we found that the levels of microtubule-unbound free tau increased by milton knockdown. Blocking tau phosphorylation at Ser262 site by PAR-1 knockdown or by mutating the Ser262 site to unphosphorylatable alanine suppressed the enhancement of tau-induced neurodegeneration caused by milton knockdown. Furthermore, knockdown of milton or Miro increased the levels of active PAR-1. These results suggest that an increase in tau phosphorylation at Ser262 through PAR-1 contributes to tau-mediated neurodegeneration under a pathological condition in which axonal mitochondria is depleted. Intriguingly, we found that knockdown of milton or Miro alone caused late-onset neurodegeneration in the fly brain, and this neurodegeneration could be suppressed by knockdown of Drosophila tau or PAR-1. Our results suggest that loss of axonal mitochondria may play an important role in tau phosphorylation and toxicity in the pathogenesis of AD. PMID:22952452

Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies.

PubMed

Arima, Kunimasa

2006-10-01

The microtubule-associated protein tau aggregates into filaments in the form of neurofibrillary tangles, neuropil threads and argyrophilic grains in neurons, in the form of variable astrocytic tangles in astrocytes and in the form of coiled bodies and argyrophilic threads in oligodendrocytes. These tau filaments may be classified into two types, straight filaments or tubules with 9-18 nm diameters and "twisted ribbons" composed of two parallel aligned components. In the same disease, the fine structure of tau filaments in glial cells roughly resembles that in neurons. In sporadic tauopathies, individual tau filaments show characteristic sizes, shapes and arrangements, and therefore contribute to neuropathologic differential diagnosis. In frontotemporal dementias caused by tau gene mutations, variable filamentous profiles were observed in association with mutation sites and insoluble tau isoforms, including straight filaments or tubules, paired helical filament-like filaments, and twisted ribbons. Pre-embedding immunoelectron microscopic studies were carried out using anti-3-repeat tau and anti-4-repeat tau specific antibodies, RD3 and RD4. Straight tubules in neuronal and astrocytic Pick bodies were immunolabeled by the anti-3-repeat tau antibody. The anti-4-repeat tau antibody recognized abnormal tubules comprising neurofibrillary tangles, coiled bodies and argyrophilic threads in progressive supranuclear palsy (PSP) and corticobasal degeneration. In the pre-embedding immunoelectron microscopic study using the phosphorylated tau AT8 antibody, tuft-shaped astrocytes of PSP were found to be composed of bundles of abnormal tubules in processes and perikarya of protoplasmic astrocytes. In this study, the 3-repeat tau or 4-repeat tau epitope was detected in situ at the ultrastructural level in abnormal tubules in representative pathological lesions in Pick's disease, PSP and corticobasal degeneration.

Acquiring information about neutrino parameters by detecting supernova neutrinos

NASA Astrophysics Data System (ADS)

Huang, Ming-Yang; Guo, Xin-Heng; Young, Bing-Lin

2010-08-01

We consider the supernova shock effects, the Mikheyev-Smirnov-Wolfenstein effects, the collective effects, and the Earth matter effects in the detection of type II supernova neutrinos on the Earth. It is found that the event number of supernova neutrinos depends on the neutrino mass hierarchy, the neutrino mixing angle θ13, and neutrino masses. Therefore, we propose possible methods to identify the mass hierarchy and acquire information about θ13 and neutrino masses by detecting supernova neutrinos. We apply these methods to some current neutrino experiments.

Neutrinos

Science.gov Websites

Neutrinos What are they? Neutrinos are members of the Standard Model, belonging to a class of the mass could be and the mass differences between flavors of neutrinos, although there are many current experiments designed to probe this question. The difficulty lies in the fact that neutrinos are

Escitalopram Ameliorates Forskolin-Induced Tau Hyperphosphorylation in HEK239/tau441 Cells.

PubMed

Ren, Qing-Guo; Wang, Yan-Juan; Gong, Wei-Gang; Zhou, Qi-Da; Xu, Lin; Zhang, Zhi-Jun

2015-06-01

To investigate the effect of escitalopram (a widely used and highly efficacious antidepressant from the SSRI class) on tau hyperphosphorylation, HEK293/tau441 cells were pretreated with 4 μM of forskolin for 2 h. Then we treated the cells with different doses of escitalopram (0, 5, 10, 20, 40, 80 μM) for 22 h. We measured the phosphorylation level of tau by Western blotting. It was shown that escitalopram could protect tau from hyperphosphorylation induced by pharmacological activation of protein kinase A (PKA) at a dose of 20, 40, and 80 μM in vitro. Interestingly, the same dose of escitalopram could also increase the level of serine-9-phosphorylated GSK-3β (inactive form) and the phosphorylation level of Akt at Ser473 (active form) with no significant change in the level of total GSK-3β and Akt. Unexpectedly, 5-hydroxytryptamine 1A receptor (5-HT1A) agonist 8-OH-DPAT did not decrease forskolin-induced tau hyperphosphorylation. Our results suggest that escitalopram can ameliorate forskolin-induced tau hyperphosphorylation, which is not through the typical 5-HT1A pathway, and Akt/GSK-3β signaling pathway is involved. These findings may support an effective role of antidepressants in the prevention of dementia associated with depression in patients.

Neutrino Detectors

NASA Astrophysics Data System (ADS)

von Feilitzsch, Franz; Lanfranchi, Jean-Côme; Wurm, Michael

The neutrino was postulated by Wolfgang Pauli in the early 1930s, but could only be detected for the first time in the 1950s. Ever since scientists all around the world have worked on the detection and understanding of this particle which so scarcely interacts with matter. Depending on the origin and nature of the neutrino, various types of experiments have been developed and operated. In this entry, we will review neutrino detectors in terms of neutrino energy and associated detection technique as well as the scientific outcome of some selected examples. After a brief historical introduction, the detection of low-energy neutrinos originating from nuclear reactors or from the Earth is used to illustrate the principles and difficulties which are encountered in detecting neutrinos. In the context of solar neutrino spectroscopy, where the neutrino is used as a probe for astrophysics, three different types of neutrino detectors are presented - water Čerenkov, radiochemical, and liquid-scintillator detectors. Moving to higher neutrino energies, we discuss neutrinos produced by astrophysical sources and from accelerators. The entry concludes with an overview of a selection of future neutrino experiments and their scientific goals.

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

PubMed Central

Luo, Wenjie; Liu, Wencheng; Hu, Xiaoyan; Hanna, Mary; Caravaca, April; Paul, Steven M.

2015-01-01

Microglia have been shown to contribute to the clearance of brain amyloid β peptides (Aβ), the major component of amyloid plaques, in Alzheimer’s disease (AD). However, it is not known whether microglia play a similar role in the clearance of tau, the major component of neurofibrillary tangles (NFTs). We now report that murine microglia rapidly internalize and degrade hyperphosphorylated pathological tau isolated from AD brain tissue in a time-dependent manner in vitro. We further demonstrate that microglia readily degrade human tau species released from AD brain sections and eliminate NFTs from brain sections of P301S tauopathy mice. The anti-tau monoclonal antibody MC1 enhances microglia-mediated tau degradation in an Fc-dependent manner. Our data identify a potential role for microglia in the degradation and clearance of pathological tau species in brain and provide a mechanism explaining the potential therapeutic actions of passively administered anti-tau monoclonal antibodies. PMID:26057852

CSF tau and tau/Aβ42 predict cognitive decline in Parkinson's disease.

PubMed

Liu, Changqin; Cholerton, Brenna; Shi, Min; Ginghina, Carmen; Cain, Kevin C; Auinger, Peggy; Zhang, Jing

2015-03-01

A substantial proportion of patients with Parkinson's disease (PD) have concomitant cognitive dysfunction. Identification of biomarker profiles that predict which PD patients have a greater likelihood for progression of cognitive symptoms is pressingly needed for future treatment and prevention approaches. Subjects were drawn from the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) study, a large clinical trial that enrolled initially untreated PD patients. For the current study, Phase One encompassed trial baseline until just prior to levodopa administration (n = 403), and Phase Two spanned the initiation of levodopa treatment until the end of cognitive follow-up (n = 305). Correlations and linear mixed models were performed to determine cross-sectional and longitudinal associations between baseline amyloid β1-42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) and measures of memory and executive function. Analyses also considered APOE genotype and tremor- vs. rigidity-dominant phenotype. No association was found between baseline CSF biomarkers and cognitive test performance during Phase One. However, once levodopa treatment was initiated, higher p-tau and p-tau/Aβ42 predicted subsequent decline on cognitive tasks involving both memory and executive functions. The interactions between biomarkers and cognition decline did not appear to be influenced by levodopa dosage, APOE genotype or motor phenotype. The current study has, for the first time, demonstrated the possible involvement of tau species, whose gene (MAPT) has been consistently linked to the risk of PD by genome-wide association studies, in the progression of cognitive symptoms in PD. Copyright © 2015 Elsevier Ltd. All rights reserved.

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.

PubMed

Congdon, Erin E; Lin, Yan; Rajamohamedsait, Hameetha B; Shamir, Dov B; Krishnaswamy, Senthilkumar; Rajamohamedsait, Wajitha J; Rasool, Suhail; Gonzalez, Veronica; Levenga, Josien; Gu, Jiaping; Hoeffer, Charles; Sigurdsson, Einar M

2016-08-30

A few tau immunotherapies are now in clinical trials with several more likely to be initiated in the near future. A priori, it can be anticipated that an antibody which broadly recognizes various pathological tau aggregates with high affinity would have the ideal therapeutic properties. Tau antibodies 4E6 and 6B2, raised against the same epitope region but of varying specificity and affinity, were tested for acutely improving cognition and reducing tau pathology in transgenic tauopathy mice and neuronal cultures. Surprisingly, we here show that one antibody, 4E6, which has low affinity for most forms of tau acutely improved cognition and reduced soluble phospho-tau, whereas another antibody, 6B2, which has high affinity for various tau species was ineffective. Concurrently, we confirmed and clarified these efficacy differences in an ex vivo model of tauopathy. Alzheimer's paired helical filaments (PHF) were toxic to the neurons and increased tau levels in remaining neurons. Both toxicity and tau seeding were prevented by 4E6 but not by 6B2. Furthermore, 4E6 reduced PHF spreading between neurons. Interestingly, 4E6's efficacy relates to its high affinity binding to solubilized PHF, whereas the ineffective 6B2 binds mainly to aggregated PHF. Blocking 4E6's uptake into neurons prevented its protective effects if the antibody was administered after PHF had been internalized. When 4E6 and PHF were administered at the same time, the antibody was protective extracellularly. Overall, these findings indicate that high antibody affinity for solubilized PHF predicts efficacy, and that acute antibody-mediated improvement in cognition relates to clearance of soluble phospho-tau. Importantly, both intra- and extracellular clearance pathways are in play. Together, these results have major implications for understanding the pathogenesis of tauopathies and for development of immunotherapies.

Physics of neutrino flavor transformation through matter–neutrino resonances

DOE PAGES

Wu, Meng -Ru; Duan, Huaiyu; Qian, Yong -Zhong

2015-11-17

In astrophysical environments such as core-collapse supernovae and neutron star–neutron star or neutron star–black hole mergers where dense neutrino media are present, matter–neutrino resonances (MNRs) can occur when the neutrino propagation potentials due to neutrino–electron and neutrino–neutrino for-ward scattering nearly cancel each other. We show that neutrino flavor transformation through MNRs can be explained by multiple adiabatic solutions similar to the Mikheyev–Smirnov–Wolfenstein mecha-nism. As a result, we find that for the normal neutrino mass hierarchy, neutrino flavor evolution through MNRs can be sensitive to the shape of neutrino spectra and the adiabaticity of the system, but such sensitivity is absentmore » for the inverted hierarchy.« less

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography.

PubMed

Mielke, Michelle M; Hagen, Clinton E; Xu, Jing; Chai, Xiyun; Vemuri, Prashanthi; Lowe, Val J; Airey, David C; Knopman, David S; Roberts, Rosebud O; Machulda, Mary M; Jack, Clifford R; Petersen, Ronald C; Dage, Jeffrey L

2018-04-04

We examined and compared plasma phospho-tau181 (pTau181) and total tau: (1) across the Alzheimer's disease (AD) clinical spectrum; (2) in relation to brain amyloid β (Aβ) positron emission tomography (PET), tau PET, and cortical thickness; and (3) as a screening tool for elevated brain Aβ. Participants included 172 cognitively unimpaired, 57 mild cognitively impaired, and 40 AD dementia patients with concurrent Aβ PET (Pittsburgh compound B), tau PET (AV1451), magnetic resonance imaging, plasma total tau, and pTau181. Plasma total tau and pTau181 levels were higher in AD dementia patients than those in cognitively unimpaired. Plasma pTau181 was more strongly associated with both Aβ and tau PET. Plasma pTau181 was a more sensitive and specific predictor of elevated brain Aβ than total tau and was as good as, or better than, the combination of age and apolipoprotein E (APOE). Plasma pTau181 may have utility as a biomarker of AD pathophysiology and as a noninvasive screener for elevated brain Aβ. Copyright © 2018. Published by Elsevier Inc.

SHiP: a new facility with a dedicated detector to search for new neutral particles and studying tau neutrino properties

NASA Astrophysics Data System (ADS)

Shevchenko, V.

2017-12-01

SHiP (Search for Hidden Particles) is a new general purpose fixed target facility, whose Technical Proposal has been recently reviewed by the CERN SPS Committee and by the CERN Research Board. The two boards recommended that the experiment proceeds further to a Comprehensive Design phase in the context of the new CERNWorking group "Physics Beyond Colliders", aiming at presenting a CERN strategy for the European Strategy meeting of 2019. In the initial phase of SHiP, the 400 GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2×1020 pot in 5 years. A dedicated detector, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below O(10) GeV/c2. The main focus will be the physics of the so-called Hidden Portals, i.e. search for Dark Photons, Light scalars and pseudo-scalars, and Heavy Neutrinos. The sensitivity to Heavy Neutrinos will allow for the first time to probe, in the mass range between the kaon and the charm meson mass, a coupling range for which Baryogenesis and active neutrino masses could also be explained. Another dedicated detector will allow the study of neutrino cross-sections and angular distributions.

Probing Neutrino Properties with Long-Baseline Neutrino Beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marino, Alysia

2015-06-29

This final report on an Early Career Award grant began in April 15, 2010 and concluded on April 14, 2015. Alysia Marino's research is focussed on making precise measurements of neutrino properties using intense accelerator-generated neutrino beams. As a part of this grant, she is collaborating on the Tokai-to-Kamioka (T2K) long-baseline neutrino experiment, currently taking data in Japan, and on the Deep Underground Neutrino Experiment (DUNE) design effort for a future Long-Baseline Neutrino Facility (LBNF) in the US. She is also a member of the NA61/SHINE particle production experiment at CERN, but as that effort is supported by other funds,more » it will not be discussed further here. T2K was designed to search for the disappearance of muon neutrinos (ν μ) and the appearance of electron neutrinos (ν e), using a beam of muon neutrino beam that travels 295 km across Japan towards the Super-Kamiokande detector. In 2011 T2K first reported indications of ν e appearance, a previously unobserved mode of neutrino oscillations. In the past year, T2K has published a combined analysis of ν μ disappearance and ν e appearance, and began collecting taking data with a beam of anti-neutrinos, instead of neutrinos, to search for hints of violation of the CP symmetry of the universe. The proposed DUNE experiment has similar physics goals to T2K, but will be much more sensitive due to its more massive detectors and new higher-intensity neutrino beam. This effort will be very high-priority particle physics project in the US over the next decade.« less

Changes in tau phosphorylation in hibernating rodents.

PubMed

León-Espinosa, Gonzalo; García, Esther; García-Escudero, Vega; Hernández, Félix; Defelipe, Javier; Avila, Jesús

2013-07-01

Tau is a cytoskeletal protein present mainly in the neurons of vertebrates. By comparing the sequence of tau molecule among different vertebrates, it was found that the variability of the N-terminal sequence in tau protein is higher than that of the C-terminal region. The N-terminal region is involved mainly in the binding of tau to cellular membranes, whereas the C-terminal region of the tau molecule contains the microtubule-binding sites. We have compared the sequence of Syrian hamster tau with the sequences of other hibernating and nonhibernating rodents and investigated how differences in the N-terminal region of tau could affect the phosphorylation level and tau binding to cell membranes. We also describe a change, in tau phosphorylation, on a casein kinase 1 (ck1)-dependent site that is found only in hibernating rodents. This ck1 site seems to play an important role in the regulation of tau binding to membranes. Copyright © 2013 Wiley Periodicals, Inc.

From Atmospheric Neutrinos to the Neutrino Mass Hierarchy

NASA Astrophysics Data System (ADS)

Kappes, A.

2015-08-01

After a brief introduction to neutrino oscillation, the article discusses how proposed detectors like PINGU and ORCA can use atmospheric neutrinos in the GeV range to determine the neutrino mass hierarchy, one of the crucial unknowns in the neutrino sector of particle physics, and what uncertainties on external input parameters have to be taken into account.

Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice*

PubMed Central

Ma, Qiu-Lan; Zuo, Xiaohong; Yang, Fusheng; Ubeda, Oliver J.; Gant, Dana J.; Alaverdyan, Mher; Teng, Edmond; Hu, Shuxin; Chen, Ping-Ping; Maiti, Panchanan; Teter, Bruce; Cole, Greg M.; Frautschy, Sally A.

2013-01-01

The mechanisms underlying Tau-related synaptic and cognitive deficits and the interrelationships between Tau species, their clearance pathways, and synaptic impairments remain poorly understood. To gain insight into these mechanisms, we examined these interrelationships in aged non-mutant genomic human Tau mice, with established Tau pathology and neuron loss. We also examined how these interrelationships changed with an intervention by feeding mice either a control diet or one containing the brain permeable beta-amyloid and Tau aggregate binding molecule curcumin. Transgene-dependent elevations in soluble and insoluble phospho-Tau monomer and soluble Tau dimers accompanied deficits in behavior, hippocampal excitatory synaptic markers, and molecular chaperones (heat shock proteins (HSPs)) involved in Tau degradation and microtubule stability. In human Tau mice but not control mice, HSP70, HSP70/HSP72, and HSP90 were reduced in membrane-enriched fractions but not in cytosolic fractions. The synaptic proteins PSD95 and NR2B were reduced in dendritic fields and redistributed into perikarya, corresponding to changes observed by immunoblot. Curcumin selectively suppressed levels of soluble Tau dimers, but not of insoluble and monomeric phospho-Tau, while correcting behavioral, synaptic, and HSP deficits. Treatment increased PSD95 co-immunoprecipitating with NR2B and, independent of transgene, increased HSPs implicated in Tau clearance. It elevated HSP90 and HSC70 without increasing HSP mRNAs; that is, without induction of the heat shock response. Instead curcumin differentially impacted HSP90 client kinases, reducing Fyn without reducing Akt. In summary, curcumin reduced soluble Tau and elevated HSPs involved in Tau clearance, showing that even after tangles have formed, Tau-dependent behavioral and synaptic deficits can be corrected. PMID:23264626

Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample.

PubMed

La Joie, Renaud; Bejanin, Alexandre; Fagan, Anne M; Ayakta, Nagehan; Baker, Suzanne L; Bourakova, Viktoriya; Boxer, Adam L; Cha, Jungho; Karydas, Anna; Jerome, Gina; Maass, Anne; Mensing, Ashley; Miller, Zachary A; O'Neil, James P; Pham, Julie; Rosen, Howard J; Tsai, Richard; Visani, Adrienne V; Miller, Bruce L; Jagust, William J; Rabinovici, Gil D

2018-01-23

To assess the relationships between fluid and imaging biomarkers of tau pathology and compare their diagnostic utility in a clinically heterogeneous sample. Fifty-three patients (28 with clinical Alzheimer disease [AD] and 25 with non-AD clinical neurodegenerative diagnoses) underwent β-amyloid (Aβ) and tau ([ 18 F]AV1451) PET and lumbar puncture. CSF biomarkers (Aβ 42 , total tau [t-tau], and phosphorylated tau [p-tau]) were measured by multianalyte immunoassay (AlzBio3). Receiver operator characteristic analyses were performed to compare discrimination of Aβ-positive AD from non-AD conditions across biomarkers. Correlations between CSF biomarkers and PET standardized uptake value ratios (SUVR) were assessed using skipped Pearson correlation coefficients. Voxelwise analyses were run to assess regional CSF-PET associations. [ 18 F]AV1451-PET cortical SUVR and p-tau showed excellent discrimination between Aβ-positive AD and non-AD conditions (area under the curve 0.92-0.94; ≤0.83 for other CSF measures), and reached 83% classification agreement. In the full sample, cortical [ 18 F]AV1451 was associated with all CSF biomarkers, most strongly with p-tau ( r = 0.75 vs 0.57 for t-tau and -0.49 for Aβ 42 ). When restricted to Aβ-positive patients with AD, [ 18 F]AV1451 SUVR correlated modestly with p-tau and t-tau (both r = 0.46) but not Aβ 42 ( r = 0.02). On voxelwise analysis, [ 18 F]AV1451 correlated with CSF p-tau in temporoparietal cortices and with t-tau in medial prefrontal regions. Within AD, Mini-Mental State Examination scores were associated with [ 18 F]AV1451-PET, but not CSF biomarkers. [ 18 F]AV1451-PET and CSF p-tau had comparable value for differential diagnosis. Correlations were robust in a heterogeneous clinical group but attenuated (although significant) in AD, suggesting that fluid and imaging biomarkers capture different aspects of tau pathology. This study provides Class III evidence that, in a clinical sample of patients with a variety

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers

PubMed Central

Puschmann, Andreas; Schöll, Michael; Ohlsson, Tomas; van Swieten, John; Honer, Michael; Englund, Elisabet

2016-01-01

Abstract Tau positron emission tomography ligands provide the novel possibility to image tau pathology in vivo. However, little is known about how in vivo brain uptake of tau positron emission tomography ligands relates to tau aggregates observed post-mortem. We performed tau positron emission tomography imaging with 18F-AV-1451 in three patients harbouring a p.R406W mutation in the MAPT gene, encoding tau. This mutation results in 3- and 4-repeat tau aggregates similar to those in Alzheimer’s disease, and many of the mutation carriers initially suffer from memory impairment and temporal lobe atrophy. Two patients with short disease duration and isolated memory impairment exhibited 18F-AV-1451 uptake mainly in the hippocampus and adjacent temporal lobe regions, correlating with glucose hypometabolism in corresponding regions. One patient died after 26 years of disease duration with dementia and behavioural deficits. Pre-mortem, there was 18F-AV-1451 uptake in the temporal and frontal lobes, as well as in the basal ganglia, which strongly correlated with the regional extent and amount of tau pathology in post-mortem brain sections. Amyloid-β (18F-flutemetamol) positron emission tomography scans were negative in all cases, as were stainings of brain sections for amyloid. This provides strong evidence that 18F-AV-1451 positron emission tomography can be used to accurately quantify in vivo the regional distribution of hyperphosphorylated tau protein. PMID:27357347

Treatment-as-usual (TAU) is anything but usual: a meta-analysis of CBT versus TAU for anxiety and depression.

PubMed

Watts, Sarah E; Turnell, Adrienne; Kladnitski, Natalie; Newby, Jill M; Andrews, Gavin

2015-04-01

There were three aims of this study, the first was to examine the efficacy of CBT versus treatment-as-usual (TAU) in the treatment of anxiety and depressive disorders, the second was to examine how TAU is defined in TAU control groups for those disorders, and the third was to explore whether the type of TAU condition influences the estimate of effects of CBT. A systematic search of Cochrane Central Register of Controlled Trials, PsycINFO, and CINAHL was conducted. 48 studies of CBT for depressive or anxiety disorders (n=6926) that specified that their control group received TAU were identified. Most (n=45/48) provided an explanation of the TAU group however there was significant heterogeneity amongst TAU conditions. The meta-analysis showed medium effects favoring CBT over TAU for both anxiety (g=0.69, 95% CI 0.47-0.92, p<0.001, n=1318) and depression (g=0.70, 95% CI 0.49-0.90, p<0.001, n=5054), with differential effects observed across TAU conditions. CBT is superior to TAU and the size of the effect of CBT compared to TAU depends on the nature of the TAU condition. The term TAU is used in different ways and should be more precisely described. The four key details to be reported can be thought of as "who, what, how many, and any additional treatments?" Copyright © 2014 Elsevier B.V. All rights reserved.

Observation of Upsilon(3S)-->tau+tau- and tests of lepton universality in Upsilon decays.

PubMed

Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Severini, H; Dytman, S A; Love, W; Savinov, V; Aquines, O; Li, Z; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Blusk, S; Butt, J; Horwitz, N; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Brock, I; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Wiss, J; Shepherd, M R

2007-02-02

Using data collected with the CLEO III detector at the CESR e+e- collider, we report on a first observation of the decay Upsilon(3S)-->tau+tau-, and precisely measure the ratio of branching fractions of Upsilon(nS), n=1, 2, 3, to tau+tau- and mu+mu- final states, finding agreement with expectations from lepton universality. We derive absolute branching fractions for these decays, and also set a limit on the influence of a low mass CP-odd Higgs boson in the decay of the Upsilon(1S).

Neutrino astronomy with supernova neutrinos

NASA Astrophysics Data System (ADS)

Brdar, Vedran; Lindner, Manfred; Xu, Xun-Jie

2018-04-01

Modern neutrino facilities will be able to detect a large number of neutrinos from the next Galactic supernova. We investigate the viability of the triangulation method to locate a core-collapse supernova by employing the neutrino arrival time differences at various detectors. We perform detailed numerical fits in order to determine the uncertainties of these time differences for the cases when the core collapses into a neutron star or a black hole. We provide a global picture by combining all the relevant current and future neutrino detectors. Our findings indicate that in the scenario of a neutron star formation, supernova can be located with precision of 1.5 and 3.5 degrees in declination and right ascension, respectively. For the black hole scenario, sub-degree precision can be reached.

Supernova Neutrino-Process and Implication in Neutrino Oscillation

NASA Astrophysics Data System (ADS)

Kajino, T.; Aoki, W.; Fujiya, W.; Mathews, G. J.; Yoshida, T.; Shaku, K.; Nakamura, K.; Hayakawa, T.

2012-08-01

We studied the supernova nucleosynthesis induced by neutrino interactions and found that several isotopes of rare elements like 7Li, 11B, 138La, 180Ta and many others are predominantly produced by the neutrino-process in core-collapse supernovae. These isotopes are strongly affected by the neutrino flavor oscillation due to the MSW (Mikheyev-Smirnov-Wolfenstein) effect. We here propose a new novel method to determine the unknown neutrino oscillation parameters, θ13 and mass hierarchy simultaneously from the supernova neutrino-process, combined with the r-process for heavy-element synthsis and the Galactic chemical evolution on light nuclei.

Measurement of the $$\\mathrm{Z}\\gamma^{*} \\to \\tau\\tau$$ cross section in pp collisions at $$\\sqrt{s} = $$ 13 TeV and validation of $$\\tau$$ lepton analysis techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, Albert M; et al.

A measurement is presented of themore » $$\\mathrm{Z}/\\gamma^{*} \\to \\tau\\tau$$ cross section in pp collisions at $$\\sqrt{s} = $$ 13 TeV, using data recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 2.3 fb$$^{-1}$$. The product of the inclusive cross section and branching fraction is measured to be $$\\sigma(\\mathrm{pp} \\to \\mathrm{Z}/\\gamma^{*}\\text{+X}) \\, \\mathcal{B}(\\mathrm{Z}/\\gamma^{*} \\to \\tau\\tau) = $$ 1848 $$\\pm$$ 12 (stat) $$\\pm$$ 67 (syst+lumi) pb, in agreement with the standard model expectation, computed at next-to-next-to-leading order accuracy in perturbative quantum chromodynamics. The measurement is used to validate new analysis techniques relevant for future measurements of $$\\tau$$ lepton production. The measurement also provides the reconstruction efficiency and energy scale for $$\\tau$$ decays to hadrons+$$\

Neutrino experiments

DOE PAGES

Lesko, K. T.

2004-02-24

This review examines a wide variety of experiments investigating neutrino interactions and neutrino properties from a variety of neutrino sources. We have witnessed remarkable progress in the past two years in settling long standing problems in neutrino physics and uncovering the first evidence for physics beyond the Standard Model in nearly 30 years. Here this paper briefly reviews this recent progress in the field of neutrino physics and highlights several significant experimental arenas and topics for the coming decade of particular interest. These highlighted experiments include the precision determination of oscillation parameters including θ 13, θ 12, Δm 12 2more » and Δm 23 2 as well as a number of fundamental properties are likely to be probed included nature of the neutrino (Majorana versus Dirac), the number of neutrino families and the neutrino’s absolute mass.« less

Neutrino factory

DOE PAGES

Bogomilov, M.; Matev, R.; Tsenov, R.; ...

2014-12-08

The properties of the neutrino provide a unique window on physics beyond that described by the standard model. The study of subleading effects in neutrino oscillations, and the race to discover CP-invariance violation in the lepton sector, has begun with the recent discovery that theta(13) > 0. The measured value of theta(13) is large, emphasizing the need for a facility at which the systematic uncertainties can be reduced to the percent level. The neutrino factory, in which intense neutrino beams are produced from the decay of muons, has been shown to outperform all realistic alternatives and to be capable ofmore » making measurements of the requisite precision. Its unique discovery potential arises from the fact that only at the neutrino factory is it practical to produce high-energy electron (anti) neutrino beams of the required intensity. This paper presents the conceptual design of the neutrino factory accelerator facility developed by the European Commission Framework Programme 7 EURO nu. Design Study consortium. EURO nu coordinated the European contributions to the International Design Study for the Neutrino Factory (the IDS-NF) collaboration. The EURO nu baseline accelerator facility will provide 10(21) muon decays per year from 12.6 GeV stored muon beams serving a single neutrino detector situated at a source-detector distance of between 1 500 km and 2 500 km. A suite of near detectors will allow definitive neutrino-scattering experiments to be performed.« less

First search for atmospheric and extraterrestrial neutrino-induced cascades with the IceCube detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abbasi, R.; Aguilar, J. A.; Andeen, K.

2011-10-01

We report on the first search for atmospheric and for diffuse astrophysical neutrino-induced showers (cascades) in the IceCube detector using 257 days of data collected in the year 2007-2008 with 22 strings active. A total of 14 events with energies above 16 TeV remained after event selections in the diffuse analysis, with an expected total background contribution of 8.3{+-}3.6. At 90% confidence we set an upper limit of E{sup 2}{Phi}{sub 90%CL}<3.6x10{sup -7} GeV{center_dot}cm{sup -2}{center_dot}s{sup -1}{center_dot}sr{sup -1} on the diffuse flux of neutrinos of all flavors in the energy range between 24 TeV and 6.6 PeV assuming that {Phi}{proportional_to}E{sup -2} andmore » the flavor composition of the {nu}{sub e} ratio {nu}{sub {mu}} ratio {nu}{sub {tau}} flux is 1 ratio 1 ratio 1 at the Earth. The atmospheric neutrino analysis was optimized for lower energies. A total of 12 events were observed with energies above 5 TeV. The observed number of events is consistent with the expected background, within the uncertainties.« less

Low-energy neutrinos

NASA Astrophysics Data System (ADS)

Ludhova, Livia

2016-05-01

There exist several kinds of sources emitting neutrinos in the MeV energy range. These low-energy neutrinos from different sources can be often detected by the same multipurpose detectors. The status-of-art of the field of solar neutrinos, geoneutrinos, and the search for sterile neutrino with artificial neutrino sources is provided here; other neutrino sources, as for example reactor or high-energy neutrinos, are described elsewhere. For each of these three fields, the present-day motivation and open questions, as well as the latest experimental results and future perspectives are discussed.

Neutrino Oscillation Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kayser, Boris

2012-06-01

To complement the neutrino-physics lectures given at the 2011 International School on Astro Particle Physics devoted to Neutrino Physics and Astrophysics (ISAPP 2011; Varenna, Italy), at the 2011 European School of High Energy Physics (ESHEP 2011; Cheila Gradistei, Romania), and, in modified form, at other summer schools, we present here a written description of the physics of neutrino oscillation. This description is centered on a new way of deriving the oscillation probability. We also provide a brief guide to references relevant to topics other than neutrino oscillation that were covered in the lectures. Neutrinos and photons are by far themore » most abundant elementary particles in the universe. Thus, if we would like to comprehend the universe, we must understand the neutrinos. Of course, studying the neutrinos is challenging, since the only known forces through which these electrically-neutral leptons interact are the weak force and gravity. Consequently, interactions of neutrinos in a detector are very rare events, so that very large detectors and intense neutrino sources are needed to make experiments feasible. Nevertheless, we have confirmed that the weak interactions of neutrinos are correctly described by the Standard Model (SM) of elementary particle physics. Moreover, in the last 14 years, we have discovered that neutrinos have nonzero masses, and that leptons mix. These discoveries have been based on the observation that neutrinos can change from one 'flavor' to another - the phenomenon known as neutrino oscillation. We shall explain the physics of neutrino oscillation, deriving the probability of oscillation in a new way. We shall also provide a very brief guide to references that can be used to study some major neutrino-physics topics other than neutrino oscillation.« less

The SHiP experiment at CERN SPS

NASA Astrophysics Data System (ADS)

Di Crescenzo, A.; SHiP Collaboration

2016-01-01

SHiP is a new general purpose fixed target facility, whose Technical Proposal has been recently submitted to the CERN SPS Committee. In its initial phase, the 400GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2×1020 pot in 5years. A dedicated detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c2. The beam dump is also an ideal source of tau neutrinos, the less known particle in the Standard Model. Another dedicated detector, based on the Emulsion Cloud Chamber technology already used in the OPERA experiment, will allow to perform for the first time measurements of the tau neutrino deep inelastic scattering cross section. Tau neutrinos will be distinguished from tau anti-neutrinos, thus providing the first observation of the tau anti-neutrino.

Neutrino Physics

DOE R&D Accomplishments Database

Lederman, L. M.

1963-01-09

The prediction and verification of the neutrino are reviewed, together with the V A theory for its interactions (particularly the difficulties with the apparent existence of two neutrinos and the high energy cross section). The Brookhaven experiment confirming the existence of two neutrinos and the cross section increase with momentum is then described, and future neutrino experiments are considered. (D.C.W.)

Matter-neutrino resonance in a multiangle neutrino bulb model

NASA Astrophysics Data System (ADS)

Vlasenko, Alexey; McLaughlin, G. C.

2018-04-01

Simulations of neutrino flavor evolution in compact merger environments have shown that neutrino flavor, and hence nucleosynthesis, can be strongly affected by the presence of matter-neutrino resonances (MNRs), where there is a cancelation between the matter and the neutrino potential. Simulations performed thus far follow flavor evolution along a single neutrino trajectory, but self-consistency requires all trajectories to be treated simultaneously, and it has not been known whether MNR phenomena would still occur in multiangle models. In this paper, we present the first fully multi-angle calculations of MNR. We find that familiar MNR phenomena, where neutrinos transform to a greater extent than anti-neutrinos and a feedback mechanism maintains the cancellation between the matter and neutrino potential, still occurs for a subset of angular bins, although the flavor transformation is not as efficient as in the single-angle case. In addition, we find other types of flavor transformation that are not seen in single-angle simulations. These flavor transformation phenomena appear to be robust and are present for a wide range of model parameters, as long as an MNR is present. Although computational constraints currently limit us to models with spherical symmetry, our results suggest that the presence of an MNR generally leads to large-scale neutrino flavor evolution in multiangle systems.

Near-atomic model of microtubule-tau interactions.

PubMed

Kellogg, Elizabeth H; Hejab, Nisreen M A; Poepsel, Simon; Downing, Kenneth H; DiMaio, Frank; Nogales, Eva

2018-06-15

Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer's disease. It is unclear which tau residues are crucial for tau-MT interactions, where tau binds on MTs, and how it stabilizes them. We used cryo-electron microscopy to visualize different tau constructs on MTs and computational approaches to generate atomic models of tau-tubulin interactions. The conserved tubulin-binding repeats within tau adopt similar extended structures along the crest of the protofilament, stabilizing the interface between tubulin dimers. Our structures explain the effect of phosphorylation on MT affinity and lead to a model of tau repeats binding in tandem along protofilaments, tethering together tubulin dimers and stabilizing polymerization interfaces. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy.

PubMed

Espíndola, Sonia Lorena; Damianich, Ana; Alvarez, Rodrigo Javier; Sartor, Manuela; Belforte, Juan Emilio; Ferrario, Juan Esteban; Gallo, Jean-Marc; Avale, María Elena

2018-04-17

The microtubule-associated protein tau regulates myriad neuronal functions, such as microtubule dynamics, axonal transport and neurite outgrowth. Tauopathies are neurodegenerative disorders characterized by the abnormal metabolism of tau, which accumulates as insoluble neuronal deposits. The adult human brain contains equal amounts of tau isoforms with three (3R) or four (4R) repeats of microtubule-binding domains, derived from the alternative splicing of exon 10 (E10) in the tau transcript. Several tauopathies are associated with imbalances of tau isoforms, due to splicing deficits. Here, we used a trans-splicing strategy to shift the inclusion of E10 in a mouse model of tauopathy that produces abnormal excess of 3R tau. Modulating the 3R/4R ratio in the prefrontal cortex led to a significant reduction of pathological tau accumulation concomitant with improvement of neuronal firing and reduction of cognitive impairments. Our results suggest promising potential for the use of RNA reprogramming in human neurodegenerative diseases. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

A 20 GeVs transparent neutrino astronomy from the North Pole?

NASA Astrophysics Data System (ADS)

Fargion, D.; D'Armiento, D.

2011-03-01

Muon neutrino astronomy is drown within a polluted atmospheric neutrino noise: indeed recent ICECUBE neutrino records at (TeVs) couldn't find any muon neutrino point source [R. Abbasi et al. (IceCube Collaboration), arXiv:1010.3980v1] being blurred by such a noisy sky. However at 24 GeV energy atmospheric muon neutrinos, while rising vertically along the terrestrial diameter, should disappear (or be severely depleted) while converting into tau flavor: any rarest vertical E≃12 GeV muon track at South Pole Deep Core volume, pointing back to North Pole, might be tracing mostly a noise-free astrophysical signal. The corresponding Deep Core 6 - 7 - 8 - 9 channels trigger maybe point in those directions and inside that energy range without much background. Analogous ν suppression do not occur so efficiently elsewhere (as SuperKamiokande) because of a much smaller volume, an un-ability to test the muon birth place, its length, its expected energy. Also the smearing of the terrestrial rotation makes Deep Core ideal: along the South-North Pole the solid angle is almost steady, the flavor ν↦ν conversion persist while the Earth is spinning around the stable poles-axis. Therefore Deep Core detector at South Pole, may scan at E≃18-27 GeV energy windows, into a narrow vertical cone Δθ≃30° for a novel ν, ν astronomy almost noise-free, pointing back toward the North Pole. Unfortunately muon (at E≃12 GeV) trace their arrival direction mostly spread around an unique string in a zenith-cone solid angle. To achieve also an azimuth angular resolution a two string detection at once is needed. Therefore the doubling of the Deep Core string number, (two new arrays of six string each, achieving an average detection distance of 36.5 m), is desirable, leading to a larger Deep Core detection mass (more than double) and a sharper zenith and azimuth angular resolution by two-string vertical axis detection. Such an improvement may show a noise free (at least factor ten) muon

Non-unitarity, sterile neutrinos, and non-standard neutrino interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blennow, Mattias; Coloma, Pilar; Fernandez-Martinez, Enrique

The simplest Standard Model extension to explain neutrino masses involves the addition of right-handed neutrinos. At some level, this extension will impact neutrino oscillation searches. In this work we explore the differences and similarities between the case in which these neutrinos are kinematically accessible (sterile neutrinos) or not (mixing matrix non-unitarity). We clarify apparent inconsistencies in the present literature when using different parametrizations to describe these effects and recast both limits in the popular neutrino non-standard interaction (NSI) formalism. We find that, in the limit in which sterile oscillations are averaged out at the near detector, their effects at themore » far detector coincide with non-unitarity at leading order, even in presence of a matter potential. We also summarize the present bounds existing in both limits and compare them with the expected sensitivities of near future facilities taking the DUNE proposal as a benchmark. We conclude that non-unitarity effects are too constrained to impact present or near future neutrino oscillation facilities but that sterile neutrinos can play an important role at long baseline experiments. As a result, the role of the near detector is also discussed in detail.« less

Non-unitarity, sterile neutrinos, and non-standard neutrino interactions

DOE PAGES

Blennow, Mattias; Coloma, Pilar; Fernandez-Martinez, Enrique; ...

2017-04-27

The simplest Standard Model extension to explain neutrino masses involves the addition of right-handed neutrinos. At some level, this extension will impact neutrino oscillation searches. In this work we explore the differences and similarities between the case in which these neutrinos are kinematically accessible (sterile neutrinos) or not (mixing matrix non-unitarity). We clarify apparent inconsistencies in the present literature when using different parametrizations to describe these effects and recast both limits in the popular neutrino non-standard interaction (NSI) formalism. We find that, in the limit in which sterile oscillations are averaged out at the near detector, their effects at themore » far detector coincide with non-unitarity at leading order, even in presence of a matter potential. We also summarize the present bounds existing in both limits and compare them with the expected sensitivities of near future facilities taking the DUNE proposal as a benchmark. We conclude that non-unitarity effects are too constrained to impact present or near future neutrino oscillation facilities but that sterile neutrinos can play an important role at long baseline experiments. As a result, the role of the near detector is also discussed in detail.« less

New neutrino physics and the altered shapes of solar neutrino spectra

NASA Astrophysics Data System (ADS)

Lopes, Ilídio

2017-01-01

Neutrinos coming from the Sun's core have been measured with high precision, and fundamental neutrino oscillation parameters have been determined with good accuracy. In this work, we estimate the impact that a new neutrino physics model, the so-called generalized Mikheyev-Smirnov-Wolfenstein (MSW) oscillation mechanism, has on the shape of some of leading solar neutrino spectra, some of which will be partially tested by the next generation of solar neutrino experiments. In these calculations, we use a high-precision standard solar model in good agreement with helioseismology data. We found that the neutrino spectra of the different solar nuclear reactions of the pp chains and carbon-nitrogen-oxygen cycle have quite distinct sensitivities to the new neutrino physics. The He P and 8B neutrino spectra are the ones in which their shapes are more affected when neutrinos interact with quarks in addition to electrons. The shapes of the 15O and 17F neutrino spectra are also modified, although in these cases the impact is much smaller. Finally, the impact in the shapes of the P P and 13N neutrino spectra is practically negligible.

Limiting neutrino magnetic moments with Borexino Phase-II solar neutrino data

NASA Astrophysics Data System (ADS)

Agostini, M.; Altenmüller, K.; Appel, S.; Atroshchenko, V.; Bagdasarian, Z.; Basilico, D.; Bellini, G.; Benziger, J.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Caprioli, S.; Carlini, M.; Cavalcante, P.; Chepurnov, A.; Choi, K.; Collica, L.; D'Angelo, D.; Davini, S.; Derbin, A.; Ding, X. F.; Di Ludovico, A.; Di Noto, L.; Drachnev, I.; Fomenko, K.; Formozov, A.; Franco, D.; Froborg, F.; Gabriele, F.; Galbiati, C.; Ghiano, C.; Giammarchi, M.; Goretti, A.; Gromov, M.; Guffanti, D.; Hagner, C.; Houdy, T.; Hungerford, E.; Ianni, Aldo; Ianni, Andrea; Jany, A.; Jeschke, D.; Kobychev, V.; Korablev, D.; Korga, G.; Kryn, D.; Laubenstein, M.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Lukyanchenko, L.; Machulin, I.; Manuzio, G.; Marcocci, S.; Martyn, J.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Muratova, V.; Neumair, B.; Oberauer, L.; Opitz, B.; Orekhov, V.; Ortica, F.; Pallavicini, M.; Papp, L.; Penek, Ã.-.; Pilipenko, N.; Pocar, A.; Porcelli, A.; Ranucci, G.; Razeto, A.; Re, A.; Redchuk, M.; Romani, A.; Roncin, R.; Rossi, N.; Schönert, S.; Semenov, D.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Stokes, L. F. F.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Thurn, J.; Toropova, M.; Unzhakov, E.; Vishneva, A.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Weinz, S.; Wojcik, M.; Wurm, M.; Yokley, Z.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.; Borexino Collaboration

2017-11-01

A search for the solar neutrino effective magnetic moment has been performed using data from 1291.5 days exposure during the second phase of the Borexino experiment. No significant deviations from the expected shape of the electron recoil spectrum from solar neutrinos have been found, and a new upper limit on the effective neutrino magnetic moment of μνeff<2.8×10 -11 μB at 90% C.L. has been set using constraints on the sum of the solar neutrino fluxes implied by the radiochemical gallium experiments. Using the limit for the effective neutrino moment, new limits for the magnetic moments of the neutrino flavor states, and for the elements of the neutrino magnetic moments matrix for Dirac and Majorana neutrinos, are derived.

Measuring B{sup {+-}}{yields}{tau}{sup {+-}}{nu} and B{sub c}{sup {+-}}{yields}{tau}{sup {+-}}{nu} at the Z peak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akeroyd, A. G.; Chen, C.H.; National Center for Theoretical Sciences, Taiwan

2008-06-01

The measurement of B{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} at the B factories provides important constraints on the parameter tan{beta}/m{sub H{sup {+-}}} in the context of models with two Higgs doublets. Limits on this decay from e{sup +}e{sup -} collisions at the Z peak were sensitive to the sum of B{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} and B{sub c}{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}}. Because of the possibly sizeable contribution from B{sub c}{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} we suggest that a signal for this combination might be observed if the CERN LEP L3 Collaboration used its total data of {approx}3.6x10{sup 6} hadronic decays of the Z boson.more » Moreover, we point out that a future linear collider operating at the Z peak (Giga Z option) could constrain tan{beta}/m{sub H{sup {+-}}} from the sum of these processes with a precision comparable to that anticipated at proposed high luminosity B factories from B{sup {+-}}{yields}{tau}{sup {+-}}{nu}{sub {tau}} alone.« less

Search for sterile neutrino oscillations in muon neutrino disappearance at MINOS/MINOS+

NASA Astrophysics Data System (ADS)

Todd, Jacob; Minos+ Collaboration

2017-01-01

A wide variety of neutrino oscillation phenomena are well-described by the standard three-flavour neutrino model, but some anomalies exist. The LSND and MiniBooNE experiments have measured electron antineutrino appearance in excess of standard oscillation predictions, which points to the possibility of a sterile neutrino with higher mass than the presently known states. MINOS, a two-detector, long-baseline neutrino oscillation experiment, was optimized for the measurement of muon neutrino disappearance in the NuMI neutrino beam. A sterile neutrino responsible for the LSND and MiniBooNE excesses would cause distortions in the charged current and neutral current MINOS spectra, which permits the search for sterile neutrinos at MINOS. In close collaboration with the Daya Bay reactor neutrino experiment, MINOS has placed strong constraints on the sterile neutrino parameter space for a model with one additional sterile neutrino. Further, the extension of data collection with MINOS+, which samples the NuMI beam in a medium energy configuration, markedly increases the sensitivity of the combined MINOS and MINOS+ sample to a 3+1-flavour sterile neutrino model.

A search for muon neutrino to electron neutrino oscillation mediated by sterile neutrinos in MINOS+

NASA Astrophysics Data System (ADS)

Germani, Stefano; Schreckenberger, Adam P.

2017-09-01

The MINOS experiment made precision measurements of the neutrino oscillation parameters that are governed by the atmospheric mass-squared splitting. These measurements were made with data that were collected while the NuMI muon neutrino beam operated in a low energy mode that peaks around 3 GeV. Today the NuMI beam is running with a higher energy mode that produces a neutrino energy spectrum that peaks around 7 GeV, allowing the MINOS+ experiment to probe neutrino oscillation phenomena that could potentially be governed by a fourth mass-squared splitting. If observed, the presence of a fourth mass-squared splitting would be compelling evidence for a sterile neutrino state. In this analysis, we will present the results of a search for νµ → νe oscillation mediated by sterile neutrinos in MINOS+. The results will be contrasted against the measurements made by the LSND experiment.

Tau regulates the subcellular localization of calmodulin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barreda, Elena Gomez de; Avila, Jesus, E-mail: javila@cbm.uam.es; CIBER de Enfermedades Neurodegenerativas, 28031 Madrid

Highlights: {yields} In this work we have tried to explain how a cytoplasmic protein could regulate a cell nuclear function. We have tested the role of a cytoplasmic protein (tau) in regulating the expression of calbindin gene. We found that calmodulin, a tau-binding protein with nuclear and cytoplasmic localization, increases its nuclear localization in the absence of tau. Since nuclear calmodulin regulates calbindin expression, a decrease in nuclear calmodulin, due to the presence of tau that retains it at the cytoplasm, results in a change in calbindin expression. -- Abstract: Lack of tau expression in neuronal cells results in amore » change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.« less

Neutrino Physics at Drexel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, Charles; Dolinski, Michelle; Neilson, Russell

Our primary goal is to improve the understanding of the properties and interactions of neutrinos. We are pursuing this by means of the DUNE long-baseline and PROSPECT short-baseline neutrino experiments. For DUNE, a neutrino beam from Fermilab will be detected at the SURF facility in South Dakota, with the aim of determining the neutrino mass hierarchy (the mass ordering of neutrino flavors), and a measurement or limit on CP-violation via neutrinos. Our near-term experimental goal is to improve the characterization of the neutrino beam by measurements of muons produced as a byproduct of neutrino beam generation, to quantify the beammore » composition and flux. The short-range neutrino program has the aim of using the HFIR reactor at Oak Ridge as a neutrino source, with a detector placed nearby to find if there are short-distance oscillations to sterile neutrino flavors, and to resolve the 'reactor neutrino spectral anomaly' which has shown up as an unexplained 'bump' in the neutrino energy spectrum in recent experiments.« less

RNA stores tau reversibly in complex coacervates

PubMed Central

Lin, Yanxian; Eschmann, Neil A.; Zhou, Hongjun; Rauch, Jennifer N.; Hernandez, Israel; Guzman, Elmer; Kosik, Kenneth S.; Han, Songi

2017-01-01

Nonmembrane-bound organelles that behave like liquid droplets are widespread among eukaryotic cells. Their dysregulation appears to be a critical step in several neurodegenerative conditions. Here, we report that tau protein, the primary constituent of Alzheimer neurofibrillary tangles, can form liquid droplets and therefore has the necessary biophysical properties to undergo liquid-liquid phase separation (LLPS) in cells. Consonant with the factors that induce LLPS, tau is an intrinsically disordered protein that complexes with RNA to form droplets. Uniquely, the pool of RNAs to which tau binds in living cells are tRNAs. This phase state of tau is held in an approximately 1:1 charge balance across the protein and the nucleic acid constituents, and can thus be maximal at different RNA:tau mass ratios, depending on the biopolymer constituents involved. This feature is characteristic of complex coacervation. We furthermore show that the LLPS process is directly and sensitively tuned by salt concentration and temperature, implying it is modulated by both electrostatic interactions between the involved protein and nucleic acid constituents, as well as net changes in entropy. Despite the high protein concentration within the complex coacervate phase, tau is locally freely tumbling and capable of diffusing through the droplet interior. In fact, tau in the condensed phase state does not reveal any immediate changes in local protein packing, local conformations and local protein dynamics from that of tau in the dilute solution state. In contrast, the population of aggregation-prone tau as induced by the complexation with heparin is accompanied by large changes in local tau conformations and irreversible aggregation. However, prolonged residency within the droplet state eventually results in the emergence of detectable β-sheet structures according to thioflavin-T assay. These findings suggest that the droplet state can incubate tau and predispose the protein toward the

Solar atmospheric neutrinos: A new neutrino floor for dark matter searches

NASA Astrophysics Data System (ADS)

Ng, Kenny C. Y.; Beacom, John F.; Peter, Annika H. G.; Rott, Carsten

2017-11-01

As is well known, dark matter direct detection experiments will ultimately be limited by a "neutrino floor," due to the scattering of nuclei by MeV neutrinos from, e.g., nuclear fusion in the Sun. Here we point out the existence of a new neutrino floor that will similarly limit indirect detection with the Sun, due to high-energy neutrinos from cosmic-ray interactions with the solar atmosphere. We have two key findings. First, solar atmospheric neutrinos ≲1 TeV cause a sensitivity floor for standard weakly interacting massive particles (WIMP) scenarios, for which higher-energy neutrinos are absorbed in the Sun. This floor will be reached once the present sensitivity is improved by just 1 order of magnitude. Second, for neutrinos ≳1 TeV , which can be isolated by muon energy loss rate, solar atmospheric neutrinos should soon be detectable in IceCube. Discovery will help probe the complicated effects of solar magnetic fields on cosmic rays. These events will be backgrounds to WIMP scenarios with long-lived mediators, for which higher-energy neutrinos can escape from the Sun.

Geometric phase of neutrinos: Differences between Dirac and Majorana neutrinos

NASA Astrophysics Data System (ADS)

Capolupo, A.; Giampaolo, S. M.; Hiesmayr, B. C.; Vitiello, G.

2018-05-01

We analyze the non-cyclic geometric phase for neutrinos. We find that the geometric phase and the total phase associated to the mixing phenomenon provide a theoretical tool to distinguish between Dirac and Majorana neutrinos. Our results hold for neutrinos propagating in vacuum and through the matter. We feed the values of the experimental parameters in our formulas in order to make contact with experiments. Although it remains an open question how the geometric phase of neutrinos could be detected, our theoretical results may open new scenarios in the investigation of the neutrino nature.

Solar Neutrinos

DOE R&D Accomplishments Database

Davis, R. Jr.; Harmer, D. S.

1964-12-01

The prospect of studying the solar energy generation process directly by observing the solar neutrino radiation has been discussed for many years. The main difficulty with this approach is that the sun emits predominantly low energy neutrinos, and detectors for observing low fluxes of low energy neutrinos have not been developed. However, experimental techniques have been developed for observing neutrinos, and one can foresee that in the near future these techniques will be improved sufficiently in sensitivity to observe solar neutrinos. At the present several experiments are being designed and hopefully will be operating in the next year or so. We will discuss an experiment based upon a neutrino capture reaction that is the inverse of the electron-capture radioactive decay of argon-37. The method depends upon exposing a large volume of a chlorine compound, removing the radioactive argon-37 and observing the characteristic decay in a small low-level counter.

Oscillation properties of active and sterile neutrinos and neutrino anomalies at short distances

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khruschov, V. V., E-mail: khruschov-vv@nrcki.ru; Fomichev, S. V., E-mail: fomichev-sv@nrcki.ru; Titov, O. A., E-mail: titov-oa@nrcki.ru

2016-09-15

A generalized phenomenological (3 + 2 + 1) model featuring three active and three sterile neutrinos that is intended for calculating oscillation properties of neutrinos for the case of a normal active neutrino mass hierarchy and a large splitting between the mass of one sterile neutrino and the masses of the other two sterile neutrinos is considered. A new parametrization and a specific form of the general mixing matrix are proposed for active and sterile neutrinos with allowance for possible CP violation in the lepton sector, and test values are chosen for the neutrino masses and mixing parameters. The probabilitiesmore » for the transitions between different neutrino flavors are calculated, and graphs representing the probabilities for the disappearance of muon neutrinos/antineutrinos and the appearance of electron neutrinos/antineutrinos in a beam of muon neutrinos/antineutrinos versus the distance from the neutrino source for various values of admissible model parameters at neutrino energies not higher than 50 MeV, as well as versus the ratio of this distance to the neutrino energy, are plotted. It is shown that the short-distance accelerator anomaly in neutrino data (LNSD anomaly) can be explained in the case of a specific mixing matrix for active and sterile neutrinos (which belongs to the a{sub 2} type) at the chosen parameter values. The same applies to the short-distance reactor and gallium anomalies. The theoretical results obtained in the present study can be used to interpret and predict the results of ground-based neutrino experiments aimed at searches for sterile neutrinos, as well as to analyze some astrophysical observational data.« less

Oscillation properties of active and sterile neutrinos and neutrino anomalies at short distances

NASA Astrophysics Data System (ADS)

Khruschov, V. V.; Fomichev, S. V.; Titov, O. A.

2016-09-01

A generalized phenomenological (3 + 2 + 1) model featuring three active and three sterile neutrinos that is intended for calculating oscillation properties of neutrinos for the case of a normal activeneutrino mass hierarchy and a large splitting between the mass of one sterile neutrino and the masses of the other two sterile neutrinos is considered. A new parametrization and a specific form of the general mixing matrix are proposed for active and sterile neutrinos with allowance for possible CP violation in the lepton sector, and test values are chosen for the neutrino masses and mixing parameters. The probabilities for the transitions between different neutrino flavors are calculated, and graphs representing the probabilities for the disappearance of muon neutrinos/antineutrinos and the appearance of electron neutrinos/antineutrinos in a beam of muon neutrinos/antineutrinos versus the distance from the neutrino source for various values of admissible model parameters at neutrino energies not higher than 50 MeV, as well as versus the ratio of this distance to the neutrino energy, are plotted. It is shown that the short-distance accelerator anomaly in neutrino data (LNSD anomaly) can be explained in the case of a specific mixing matrix for active and sterile neutrinos (which belongs to the a 2 type) at the chosen parameter values. The same applies to the short-distance reactor and gallium anomalies. The theoretical results obtained in the present study can be used to interpret and predict the results of ground-based neutrino experiments aimed at searches for sterile neutrinos, as well as to analyze some astrophysical observational data.

The Intermediate Neutrino Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, C.; Alonso, J. R.; Ankowski, A. M.

2017-04-03

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topicsmore » on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop.« less

Toroidal magnetized iron neutrino detector for a neutrino factory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bross, A.; Wands, R.; Bayes, R.

2013-08-01

A neutrino factory has unparalleled physics reach for the discovery and measurement of CP violation in the neutrino sector. A far detector for a neutrino factory must have good charge identification with excellent background rejection and a large mass. An elegant solution is to construct a magnetized iron neutrino detector (MIND) along the lines of MINOS, where iron plates provide a toroidal magnetic field and scintillator planes provide 3D space points. In this report, the current status of a simulation of a toroidal MIND for a neutrino factory is discussed in light of the recent measurements of largemore » $$\\theta_{13}$$. The response and performance using the 10 GeV neutrino factory configuration are presented. It is shown that this setup has equivalent $$\\delta_{CP}$$ reach to a MIND with a dipole field and is sensitive to the discovery of CP violation over 85% of the values of $$\\delta_{CP}$$.« less

Measurement of the Neutrino Mixing Angle θ23 in NOvA

NASA Astrophysics Data System (ADS)

Adamson, P.; Aliaga, L.; Ambrose, D.; Anfimov, N.; Antoshkin, A.; Arrieta-Diaz, E.; Augsten, K.; Aurisano, A.; Backhouse, C.; Baird, M.; Bambah, B. A.; Bays, K.; Behera, B.; Bending, S.; Bernstein, R.; Bhatnagar, V.; Bhuyan, B.; Bian, J.; Blackburn, T.; Bolshakova, A.; Bromberg, C.; Brown, J.; Brunetti, G.; Buchanan, N.; Butkevich, A.; Bychkov, V.; Campbell, M.; Catano-Mur, E.; Childress, S.; Choudhary, B. C.; Chowdhury, B.; Coan, T. E.; Coelho, J. A. B.; Colo, M.; Cooper, J.; Corwin, L.; Cremonesi, L.; Cronin-Hennessy, D.; Davies, G. S.; Davies, J. P.; Derwent, P. F.; Desai, S.; Dharmapalan, R.; Ding, P.; Djurcic, Z.; Dukes, E. C.; Duyang, H.; Edayath, S.; Ehrlich, R.; Feldman, G. J.; Frank, M. J.; Gabrielyan, M.; Gallagher, H. R.; Germani, S.; Ghosh, T.; Giri, A.; Gomes, R. A.; Goodman, M. C.; Grichine, V.; Group, R.; Grover, D.; Guo, B.; Habig, A.; Hartnell, J.; Hatcher, R.; Hatzikoutelis, A.; Heller, K.; Himmel, A.; Holin, A.; Hylen, J.; Jediny, F.; Judah, M.; Kafka, G. K.; Kalra, D.; Kasahara, S. M. S.; Kasetti, S.; Keloth, R.; Kolupaeva, L.; Kotelnikov, S.; Kourbanis, I.; Kreymer, A.; Kumar, A.; Kurbanov, S.; Lang, K.; Lee, W. M.; Lin, S.; Liu, J.; Lokajicek, M.; Lozier, J.; Luchuk, S.; Maan, K.; Magill, S.; Mann, W. A.; Marshak, M. L.; Matera, K.; Matveev, V.; Méndez, D. P.; Messier, M. D.; Meyer, H.; Miao, T.; Miller, W. H.; Mishra, S. R.; Mohanta, R.; Moren, A.; Mualem, L.; Muether, M.; Mufson, S.; Murphy, R.; Musser, J.; Nelson, J. K.; Nichol, R.; Niner, E.; Norman, A.; Nosek, T.; Oksuzian, Y.; Olshevskiy, A.; Olson, T.; Paley, J.; Pandey, P.; Patterson, R. B.; Pawloski, G.; Pershey, D.; Petrova, O.; Petti, R.; Phan-Budd, S.; Plunkett, R. K.; Poling, R.; Potukuchi, B.; Principato, C.; Psihas, F.; Radovic, A.; Rameika, R. A.; Rebel, B.; Reed, B.; Rocco, D.; Rojas, P.; Ryabov, V.; Sachdev, K.; Sail, P.; Samoylov, O.; Sanchez, M. C.; Schroeter, R.; Sepulveda-Quiroz, J.; Shanahan, P.; Sheshukov, A.; Singh, J.; Singh, J.; Singh, P.; Singh, V.; Smolik, J.; Solomey, N.; Song, E.; Sousa, A.; Soustruznik, K.; Strait, M.; Suter, L.; Talaga, R. L.; Tamsett, M. C.; Tas, P.; Thayyullathil, R. B.; Thomas, J.; Tian, X.; Tognini, S. C.; Tripathi, J.; Tsaris, A.; Urheim, J.; Vahle, P.; Vasel, J.; Vinton, L.; Vold, A.; Vrba, T.; Wang, B.; Wetstein, M.; Whittington, D.; Wojcicki, S. G.; Wolcott, J.; Yadav, N.; Yang, S.; Zalesak, J.; Zamorano, B.; Zwaska, R.; NOvA Collaboration

2017-04-01

This Letter reports new results on muon neutrino disappearance from NOvA, using a 14 kton detector equivalent exposure of 6.05 ×1 020 protons on target from the NuMI beam at the Fermi National Accelerator Laboratory. The measurement probes the muon-tau symmetry hypothesis that requires maximal θ23 mixing (θ23=π /4 ). Assuming the normal mass hierarchy, we find Δ m322 =(2.67 ±0.11 )×10-3 eV2 and sin2θ23 at the two statistically degenerate values 0.40 4-0.022+0.030 and 0.62 4-0.030+0.022, both at the 68% confidence level. Our data disfavor the maximal mixing scenario with 2.6 σ significance.

Measurement of the neutrino mixing angle θ 23 in NOvA

DOE PAGES

Adamson, P.; Aliaga, L.; Ambrose, D.; ...

2017-04-10

This Letter reports new results on muon neutrino disappearance from NOvA, using a 14 kton detector equivalent exposure ofmore » $$6.05\\times10^{20}$$ protons-on-target from the NuMI beam at the Fermi National Accelerator Laboratory. The measurement probes the muon-tau symmetry hypothesis that requires maximal mixing ($$\\theta_{23} = \\pi/4$$). Assuming the normal mass hierarchy, we find $$\\Delta m^2 = (2.67 \\pm 0.11)\\times 10^{-3}$$ eV$^2$ and $$\\sin^2 \\theta_{23}$$ at the two statistically degenerate values $$0.404^{+0.030}_{-0.022}$$ and $$0.624^{+0.022}_{-0.030}$$, both at the 68% confidence level. Finally, our data disfavor the maximal mixing scenario with 2.6 $$\\sigma$$ significance.« less

Insulin dysfunction and Tau pathology.

PubMed

El Khoury, Noura B; Gratuze, Maud; Papon, Marie-Amélie; Bretteville, Alexis; Planel, Emmanuel

2014-01-01

The neuropathological hallmarks of Alzheimer's disease (AD) include senile plaques of β-amyloid (Aβ) peptides (a cleavage product of the Amyloid Precursor Protein, or APP) and neurofibrillary tangles (NFT) of hyperphosphorylated Tau protein assembled in paired helical filaments (PHF). NFT pathology is important since it correlates with the degree of cognitive impairment in AD. Only a small proportion of AD is due to genetic variants, whereas the large majority of cases (~99%) is late onset and sporadic in origin. The cause of sporadic AD is likely to be multifactorial, with external factors interacting with biological or genetic susceptibilities to accelerate the manifestation of the disease. Insulin dysfunction, manifested by diabetes mellitus (DM) might be such factor, as there is extensive data from epidemiological studies suggesting that DM is associated with an increased relative risk for AD. Type 1 diabetes (T1DM) and type 2 diabetes (T2DM) are known to affect multiple cognitive functions in patients. In this context, understanding the effects of diabetes on Tau pathogenesis is important since Tau pathology show a strong relationship to dementia in AD, and to memory loss in normal aging and mild cognitive impairment. Here, we reviewed preclinical studies that link insulin dysfunction to Tau protein pathogenesis, one of the major pathological hallmarks of AD. We found more than 30 studies reporting Tau phosphorylation in a mouse or rat model of insulin dysfunction. We also payed attention to potential sources of artifacts, such as hypothermia and anesthesia, that were demonstrated to results in Tau hyperphosphorylation and could major confounding experimental factors. We found that very few studies reported the temperature of the animals, and only a handful did not use anesthesia. Overall, most published studies showed that insulin dysfunction can promote Tau hyperphosphorylation and pathology, both directly and indirectly, through hypothermia.

Insulin dysfunction and Tau pathology

PubMed Central

El Khoury, Noura B.; Gratuze, Maud; Papon, Marie-Amélie; Bretteville, Alexis; Planel, Emmanuel

2013-01-01

The neuropathological hallmarks of Alzheimer's disease (AD) include senile plaques of β-amyloid (Aβ) peptides (a cleavage product of the Amyloid Precursor Protein, or APP) and neurofibrillary tangles (NFT) of hyperphosphorylated Tau protein assembled in paired helical filaments (PHF). NFT pathology is important since it correlates with the degree of cognitive impairment in AD. Only a small proportion of AD is due to genetic variants, whereas the large majority of cases (~99%) is late onset and sporadic in origin. The cause of sporadic AD is likely to be multifactorial, with external factors interacting with biological or genetic susceptibilities to accelerate the manifestation of the disease. Insulin dysfunction, manifested by diabetes mellitus (DM) might be such factor, as there is extensive data from epidemiological studies suggesting that DM is associated with an increased relative risk for AD. Type 1 diabetes (T1DM) and type 2 diabetes (T2DM) are known to affect multiple cognitive functions in patients. In this context, understanding the effects of diabetes on Tau pathogenesis is important since Tau pathology show a strong relationship to dementia in AD, and to memory loss in normal aging and mild cognitive impairment. Here, we reviewed preclinical studies that link insulin dysfunction to Tau protein pathogenesis, one of the major pathological hallmarks of AD. We found more than 30 studies reporting Tau phosphorylation in a mouse or rat model of insulin dysfunction. We also payed attention to potential sources of artifacts, such as hypothermia and anesthesia, that were demonstrated to results in Tau hyperphosphorylation and could major confounding experimental factors. We found that very few studies reported the temperature of the animals, and only a handful did not use anesthesia. Overall, most published studies showed that insulin dysfunction can promote Tau hyperphosphorylation and pathology, both directly and indirectly, through hypothermia. PMID:24574966

No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau).

PubMed

Krut, Jan J; Price, Richard W; Zetterberg, Henrik; Fuchs, Dietmar; Hagberg, Lars; Yilmaz, Aylin; Cinque, Paola; Nilsson, Staffan; Gisslén, Magnus

2017-07-04

The prevalence of neurocognitive deficits are reported to be high in HIV-1 positive patients, even with suppressive antiretroviral treatment, and it has been suggested that HIV can cause accelerated aging of the brain. In this study we measured phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) as a potential marker for premature central nervous system (CNS) aging. P-tau increases with normal aging but is not affected by HIV-associated neurocognitive disorders. With a cross-sectional retrospective design, p-tau, total tau (t-tau), neopterin and HIV-RNA were measured in CSF together with plasma HIV-RNA and blood CD4 + T-cells of 225 HIV-infected patients <50 y of age, subdivided into 3 groups: untreated neuroasymptomatic (NA) (n = 145), on suppressive antiretroviral treatment (cART) (n = 49), and HIV-associated dementia (HAD) (n = 31). HIV-negative healthy subjects served as controls (n = 79). P-tau was not significantly higher in any HIV-infected group compared to HIV-negative controls. Significant increases in t-tau were found as expected in patients with HAD compared to NA, cART, and control groups (p < 0.001 ). P-tau was not higher in HIV-infected patients compared to uninfected controls, thus failing to support a role for premature or accelerated brain aging in HIV infection.

Latest results on νμ → ντ oscillations from the OPERA experiment

NASA Astrophysics Data System (ADS)

Komatsu, Masahiro; OPERA Collaboration

2016-04-01

The OPERA experiment is designed to prove neutrino oscillations in the νμ to ντ channel through the direct observation of the tau lepton in tau neutrino charged current interactions. The experiment has accumulated data for five years, from 2008 to 2012, with the CERN Neutrinos to Gran Sasso (CNGS), an almost pure νμ beam. In the last two years, a very large amount of the data accumulated in the nuclear emulsions has been analyzed. The latest results on oscillations with the increased statistics, which include a fourth tau neutrino candidate event, will be presented. Given the extremely low expected background, this result corresponds to the observation of the oscillation process with a four sigma level significance.

cuTauLeaping: A GPU-Powered Tau-Leaping Stochastic Simulator for Massive Parallel Analyses of Biological Systems

PubMed Central

Besozzi, Daniela; Pescini, Dario; Mauri, Giancarlo

2014-01-01

Tau-leaping is a stochastic simulation algorithm that efficiently reconstructs the temporal evolution of biological systems, modeled according to the stochastic formulation of chemical kinetics. The analysis of dynamical properties of these systems in physiological and perturbed conditions usually requires the execution of a large number of simulations, leading to high computational costs. Since each simulation can be executed independently from the others, a massive parallelization of tau-leaping can bring to relevant reductions of the overall running time. The emerging field of General Purpose Graphic Processing Units (GPGPU) provides power-efficient high-performance computing at a relatively low cost. In this work we introduce cuTauLeaping, a stochastic simulator of biological systems that makes use of GPGPU computing to execute multiple parallel tau-leaping simulations, by fully exploiting the Nvidia's Fermi GPU architecture. We show how a considerable computational speedup is achieved on GPU by partitioning the execution of tau-leaping into multiple separated phases, and we describe how to avoid some implementation pitfalls related to the scarcity of memory resources on the GPU streaming multiprocessors. Our results show that cuTauLeaping largely outperforms the CPU-based tau-leaping implementation when the number of parallel simulations increases, with a break-even directly depending on the size of the biological system and on the complexity of its emergent dynamics. In particular, cuTauLeaping is exploited to investigate the probability distribution of bistable states in the Schlögl model, and to carry out a bidimensional parameter sweep analysis to study the oscillatory regimes in the Ras/cAMP/PKA pathway in S. cerevisiae. PMID:24663957

Neutrino Telescopes

NASA Astrophysics Data System (ADS)

de Marzo, C. N.

2002-06-01

Neutrino astronomy is one of the frontier of the high energy astrophysics. I discuss how to build a neutrino telescope and which requirements such a detector must fulfil. A measurable flux of astrophysical neutrinos is predicted by several models for a detector at the cubic kilometer scale. The way pursued until now in building such huge apparatuses is Cherenkov light detection in water or in ice. There have been attempts to build neutrino telescopes and also some projects are yet under construction or under way to start. This situation is reviewed and also techniques alternatives to the Cherenkov light detection are mentioned.

Long-Baseline Neutrino Experiments

DOE PAGES

Diwan, M. V.; Galymov, V.; Qian, X.; ...

2016-10-19

We review long-baseline neutrino experiments in which neutrinos are detected after traversing macroscopic distances. Over such distances neutrinos have been found to oscillate among flavor states. Experiments with solar, atmospheric, reactor, and accelerator neutrinos have resulted in a coherent picture of neutrino masses and mixing of the three known flavor states. We will summarize the current best knowledge of neutrino parameters and phenomenology with our focus on the evolution of the experimental technique. We will proceed from the rst evidence produced by astrophysical neutrino sources to the current open questions and the goals of future research

Caspase-2 cleavage of tau reversibly impairs memory.

PubMed

Zhao, Xiaohui; Kotilinek, Linda A; Smith, Benjamin; Hlynialuk, Chris; Zahs, Kathleen; Ramsden, Martin; Cleary, James; Ashe, Karen H

2016-11-01

In Alzheimer's disease (AD) and other tauopathies, the tau protein forms fibrils, which are believed to be neurotoxic. However, fibrillar tau has been dissociated from neuron death and network dysfunction, suggesting the involvement of nonfibrillar species. Here we describe a novel pathological process in which caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines. The truncation product, Δtau314, resists fibrillation and is present at higher levels in brains from cognitively impaired mice and humans with AD. The expression of tau mutants that resisted caspase-2 cleavage prevented tau from infiltrating spines, dislocating glutamate receptors and impairing synaptic function in cultured neurons, and it prevented memory deficits and neurodegeneration in mice. Decreasing the levels of caspase-2 restored long-term memory in mice that had existing deficits. Our results suggest an overall treatment strategy for re-establishing synaptic function and restoring memory in patients with AD by preventing tau from accumulating in dendritic spines.

Sterile neutrinos in cosmology

NASA Astrophysics Data System (ADS)

Abazajian, Kevork N.

2017-11-01

Sterile neutrinos are natural extensions to the standard model of particle physics in neutrino mass generation mechanisms. If they are relatively light, less than approximately 10 keV, they can alter cosmology significantly, from the early Universe to the matter and radiation energy density today. Here, we review the cosmological role such light sterile neutrinos can play from the early Universe, including production of keV-scale sterile neutrinos as dark matter candidates, and dynamics of light eV-scale sterile neutrinos during the weakly-coupled active neutrino era. We review proposed signatures of light sterile neutrinos in cosmic microwave background and large scale structure data. We also discuss keV-scale sterile neutrino dark matter decay signatures in X-ray observations, including recent candidate ∼3.5 keV X-ray line detections consistent with the decay of a ∼7 keV sterile neutrino dark matter particle.

Neutrino phenomenology

DOE PAGES

Coloma, Pilar

2016-11-21

Neutrino oscillations have demonstrated that neutrinos have mass and, by now, oscillation experiments have been able to determine most of the parameters in the leptonic mixing matrix with a very good accuracy. Nevertheless, there are still many open questions in the neutrino sector. As a result, I will briefly discuss some of these questions, pointing out possible experimental avenues to address them.

Solar neutrino spectroscopy

NASA Astrophysics Data System (ADS)

Wurm, Michael

2017-04-01

More than forty years after the first detection of neutrinos from the Sun, the spectroscopy of solar neutrinos has proven to be an on-going success story. The long-standing puzzle about the observed solar neutrino deficit has been resolved by the discovery of neutrino flavor oscillations. Today's experiments have been able to solidify the standard MSW-LMA oscillation scenario by performing precise measurements over the whole energy range of the solar neutrino spectrum. This article reviews the enabling experimental technologies: On the one hand multi-kiloton-scale water Cherenkov detectors performing measurements in the high-energy regime of the spectrum, on the other end ultrapure liquid-scintillator detectors that allow for a low-threshold analysis. The current experimental results on the fluxes, spectra and time variation of the different components of the solar neutrino spectrum will be presented, setting them in the context of both neutrino oscillation physics and the hydrogen fusion processes embedded in the Standard Solar Model. Finally, the physics potential of state-of-the-art detectors and a next generation of experiments based on novel techniques will be assessed in the context of the most interesting open questions in solar neutrino physics: a precise measurement of the vacuum-matter transition curve of electron-neutrino oscillation probability that offers a definitive test of the basic MSW-LMA scenario or the appearance of new physics; and a first detection of neutrinos from the CNO cycle that will provide new information on solar metallicity and stellar physics.

Sterile Neutrinos and Seesaws

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lincoln, Don

Time and again, the study of neutrinos has confounded scientists. One very peculiar property of neutrinos is that only neutrinos with a specific spin configuration have been observed. In this video, Fermilab’s Dr. Don Lincoln talks about this and lays out the possibility that other types of neutrinos might exist, called right handed or sterile neutrinos.

Pseudoscalar—sterile neutrino interactions: reconciling the cosmos with neutrino oscillations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Archidiacono, Maria; Gariazzo, Stefano; Giunti, Carlo

2016-08-01

The Short BaseLine (SBL) neutrino oscillation anomalies hint at the presence of a sterile neutrino with a mass of around 1 eV. However, such a neutrino is incompatible with cosmological data, in particular observations of the Cosmic Microwave Background (CMB) anisotropies. However, this conclusion can change by invoking new physics. One possibility is to introduce a secret interaction in the sterile neutrino sector mediated by a light pseudoscalar. In this pseudoscalar model, CMB data prefer a sterile neutrino mass that is fully compatible with the mass ranges suggested by SBL anomalies. In addition, this model predicts a value of themore » Hubble parameter which is completely consistent with local measurements.« less

Neutrinos from AGN

NASA Technical Reports Server (NTRS)

Kazanas, Demosthenes; White, Nicholas E. (Technical Monitor)

2000-01-01

The great penetrating power of neutrinos makes them ideal probe of astrophysical sites and conditions inaccessible to other forms of radiation. These are the centers of stars (collapsing or not) and the centers of Active Galactic Nuclei (AGN). It has been suggested that AGN presented a very promising source of high energy neutrinos, possibly detectable by underwater neutrino detectors. This paper reviews the evolution of ideas concerning the emission of neutrinos from AGN in view of the more recent developments in gamma-ray astronomy and their implications for the neutrino emission from these class of objects.

Homestake result, sterile neutrinos, and low energy solar neutrino experiments

NASA Astrophysics Data System (ADS)

de Holanda, P. C.; Smirnov, A. Yu.

2004-06-01

The Homestake result is about ˜2σ lower than the Ar-production rate, QAr, predicted by the large mixing angle (LMA) Mikheyev-Smirnov-Wolfenstein solution of the solar neutrino problem. Also there is no apparent upturn of the energy spectrum (R≡Nobs/NSSM) at low energies in SNO and Super-Kamiokande. Both these facts can be explained if a light, Δm201˜(0.2 2)×10-5 eV2, sterile neutrino exists which mixes very weakly with active neutrinos: sin2 2α˜(10-5 10-3). We perform both the analytical and numerical study of the conversion effects in the system of two active neutrinos with the LMA parameters and one weakly mixed sterile neutrino. The presence of sterile neutrino leads to a dip in the survival probability in the intermediate energy range E=(0.5 5) MeV thus suppressing the Be, or/and pep, CNO, as well as B electron neutrino fluxes. Apart from diminishing QAr it leads to decrease of the Ge-production rate and may lead to the decrease of the BOREXINO signal as well as the CC/NC ratio at SNO. Future studies of the solar neutrinos by SNO, SK, BOREXINO, and KamLAND as well as by the new low energy experiments will allow us to check this possibility.

Simulated Cytoskeletal Collapse via Tau Degradation

PubMed Central

Sendek, Austin; Fuller, Henry R.; Hayre, N. Robert; Singh, Rajiv R. P.; Cox, Daniel L.

2014-01-01

We present a coarse-grained two dimensional mechanical model for the microtubule-tau bundles in neuronal axons in which we remove taus, as can happen in various neurodegenerative conditions such as Alzheimers disease, tauopathies, and chronic traumatic encephalopathy. Our simplified model includes (i) taus modeled as entropic springs between microtubules, (ii) removal of taus from the bundles due to phosphorylation, and (iii) a possible depletion force between microtubules due to these dissociated phosphorylated taus. We equilibrate upon tau removal using steepest descent relaxation. In the absence of the depletion force, the transverse rigidity to radial compression of the bundles falls to zero at about 60% tau occupancy, in agreement with standard percolation theory results. However, with the attractive depletion force, spring removal leads to a first order collapse of the bundles over a wide range of tau occupancies for physiologically realizable conditions. While our simplest calculations assume a constant concentration of microtubule intercalants to mediate the depletion force, including a dependence that is linear in the detached taus yields the same collapse. Applying percolation theory to removal of taus at microtubule tips, which are likely to be the protective sites against dynamic instability, we argue that the microtubule instability can only obtain at low tau occupancy, from 0.06–0.30 depending upon the tau coordination at the microtubule tips. Hence, the collapse we discover is likely to be more robust over a wide range of tau occupancies than the dynamic instability. We suggest in vitro tests of our predicted collapse. PMID:25162587

Upper bound on neutrino mass based on T2K neutrino timing measurements

NASA Astrophysics Data System (ADS)

Abe, K.; Adam, J.; Aihara, H.; Akiri, T.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bartet-Friburg, P.; Bass, M.; Batkiewicz, M.; Bay, F.; Berardi, V.; Berger, B. E.; Berkman, S.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Bolognesi, S.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Chikuma, N.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S. R.; Densham, C.; Dewhurst, D.; Di Lodovico, F.; Di Luise, S.; Dolan, S.; Drapier, O.; Duboyski, T.; Duffy, K.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Emery-Schrenk, S.; Ereditato, A.; Escudero, L.; Feusels, T.; Finch, A. J.; Fiorentini, G. A.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Garcia, A.; Giffin, S.; Giganti, C.; Gilje, K.; Goeldi, D.; Golan, T.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haegel, L.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayashino, T.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Hosomi, F.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Iwai, E.; Iwamoto, K.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Jiang, M.; Johnson, R. A.; Johnson, S.; Jo, J. H.; Jonsson, P.; Jung, C. K.; Kabirnezhad, M.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Katori, T.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J.; King, S.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Koch, L.; Koga, T.; Kolaceke, A.; Konaka, A.; Kopylov, A.; Kormos, L. L.; Korzenev, A.; Koshio, Y.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kurjata, R.; Kutter, T.; Lagoda, J.; Lamont, I.; Larkin, E.; Laveder, M.; Lawe, M.; Lazos, M.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Lopez, J. P.; Ludovici, L.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marino, A. D.; Marteau, J.; Martin, J. F.; Martins, P.; Martynenko, S.; Maruyama, T.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Mefodiev, A.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Missert, A.; Miura, M.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nakadaira, T.; Nakahata, M.; Nakamura, K. G.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Nantais, C.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; Nowak, J.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Ovsyannikova, T.; Owen, R. A.; Oyama, Y.; Palladino, V.; Palomino, J. L.; Paolone, V.; Payne, D.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pickard, L.; Pinzon Guerra, E. S.; Pistillo, C.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala-Zezula, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Redij, A.; Reeves, M.; Reinherz-Aronis, E.; Riccio, C.; Rodrigues, P. A.; Rojas, P.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Rychter, A.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schoppmann, S.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shah, R.; Shaker, F.; Shaw, D.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suda, Y.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. K.; Tanaka, H. A.; Tanaka, M. M.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Wakamatsu, K.; Walter, C. W.; Wark, D.; Warzycha, W.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Yoo, J.; Yoshida, K.; Yuan, T.; Yu, M.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.; T2K Collaboration

2016-01-01

The Tokai to Kamioka (T2K) long-baseline neutrino experiment consists of a muon neutrino beam, produced at the J-PARC accelerator, a near detector complex and a large 295-km-distant far detector. The present work utilizes the T2K event timing measurements at the near and far detectors to study neutrino time of flight as a function of derived neutrino energy. Under the assumption of a relativistic relation between energy and time of flight, constraints on the neutrino rest mass can be derived. The sub-GeV neutrino beam in conjunction with timing precision of order tens of ns provide sensitivity to neutrino mass in the few MeV /c2 range. We study the distribution of relative arrival times of muon and electron neutrino candidate events at the T2K far detector as a function of neutrino energy. The 90% C.L. upper limit on the mixture of neutrino mass eigenstates represented in the data sample is found to be mν2<5.6 MeV2/c4 .

Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice.

PubMed

Umeda, Tomohiro; Yamashita, Takenari; Kimura, Tetsuya; Ohnishi, Kiyouhisa; Takuma, Hiroshi; Ozeki, Tomoko; Takashima, Akihiko; Tomiyama, Takami; Mori, Hiroshi

2013-07-01

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is a neurodegenerative disorder caused by mutations in the tau gene. Many mutations identified in FTDP-17 have been shown to affect tau exon 10 splicing in vitro, which presumably causes pathologic imbalances in exon 10(-) [3-repeat (3R)] and exon 10(+) [4-repeat (4R)] tau expression and leads to intracellular inclusions of hyperphosphorylated tau in patient brains. However, no reports have investigated this theory using model mice with a tau intronic mutation. Herein, we generated new transgenic mice harboring the tau intron 10 +16C → T mutation. We prepared a transgene construct containing intronic sequences required for exon 10 splicing in the longest tau isoform cDNA. Although mice bearing the construct without the intronic mutation showed normal developmental changes of the tau isoform from 3R tau to equal amounts of 3R and 4R tau, mice with the mutation showed much higher levels of 4R tau at the adult stage. 4R tau was selectively recovered in insoluble brain fractions in their old age. Furthermore, these mice displayed abnormal tau phosphorylation, synapse loss and dysfunction, memory impairment, glial activation, tangle formation, and neuronal loss in an age-dependent manner. These findings provide the first evidence in a mouse model that a tau intronic mutation-induced imbalance of 3R and 4R tau could be a cause of tauopathy. Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Search for muon neutrino disappearance due to sterile neutrino oscillations with the MINOS/MINOS+ experiment

NASA Astrophysics Data System (ADS)

Todd, J.; Chen, R.; Huang, J.; ">MINOS, neutrino oscillations have successfully explained a wide range of neutrino oscillation data. However, anomalous results, such as the electron antineutrino appearance excesses seen by LSND and MiniBooNE, can be explained by the addition of a sterile neutrino at a larger mass scale than the existing three neutrino mass states. MINOS is a two-detector, long-baseline neutrino oscillation experiment optimized to measure muon neutrino disappearance in the NuMI neutrino beam. MINOS+ is the continuation of the MINOS experiment with the NuMI beam in a medium energy configuration. In the model with one sterile neutrino flavor added to the three active neutrino flavors, a sterile neutrino causing electron antineutrino appearance at LSND and MiniBooNE would also cause muon neutrino disappearance at MINOS. The sterile neutrino signature would be seen as modulations at high energy in the charged-current muon neutrino spectrum and a depletion of events in the neutral current spectrum. These proceedings show new results from fitting neutral-current and charged-current energy spectra from MINOS and MINOS+ data to a neutrino oscillation model assuming one sterile neutrino.

Neutrino Cross Sections

NASA Astrophysics Data System (ADS)

Fields, Laura

2014-03-01

The next generation of neutrino oscillation experiments aims to answer many interesting questions such as whether there is CP violation in the neutrino sector and whether sterile neutrinos exist. These esperiments will require high precision cross section measurements of various neutrino and antineutrino channels. Results and prosepects for such measurements from the MINERvA, MiniBooNE, T2K and ArgoNeuT collaborations will be reviewed.

Astroparticle physics with solar neutrinos

PubMed Central

NAKAHATA, Masayuki

2011-01-01

Solar neutrino experiments observed fluxes smaller than the expectations from the standard solar model. This discrepancy is known as the “solar neutrino problem”. Flux measurements by Super-Kamiokande and SNO have demonstrated that the solar neutrino problem is due to neutrino oscillations. Combining the results of all solar neutrino experiments, parameters for solar neutrino oscillations are obtained. Correcting for the effect of neutrino oscillations, the observed neutrino fluxes are consistent with the prediction from the standard solar model. In this article, results of solar neutrino experiments are reviewed with detailed descriptions of what Kamiokande and Super-Kamiokande have contributed to the history of astroparticle physics with solar neutrino measurements. PMID:21558758

Astroparticle physics with solar neutrinos.

PubMed

Nakahata, Masayuki

2011-01-01

Solar neutrino experiments observed fluxes smaller than the expectations from the standard solar model. This discrepancy is known as the "solar neutrino problem". Flux measurements by Super-Kamiokande and SNO have demonstrated that the solar neutrino problem is due to neutrino oscillations. Combining the results of all solar neutrino experiments, parameters for solar neutrino oscillations are obtained. Correcting for the effect of neutrino oscillations, the observed neutrino fluxes are consistent with the prediction from the standard solar model. In this article, results of solar neutrino experiments are reviewed with detailed descriptions of what Kamiokande and Super-Kamiokande have contributed to the history of astroparticle physics with solar neutrino measurements. (Communicated by Toshimitsu Yamazaki, M.J.A.).

A measurement of neutrino oscillations with muon neutrinos in the MINOS experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coleman, Stephen James

2011-05-01

Experimental evidence has established that neutrino flavor states evolve over time. A neutrino of a particular flavor that travels some distance can be detected in a different neutrino flavor state. The Main Injector Neutrino Oscillation Search (MINOS) is a long-baseline experiment that is designed to study this phenomenon, called neutrino oscillations. MINOS is based at Fermilab near Chicago, IL, and consists of two detectors: the Near Detector located at Fermilab, and the Far Detector, which is located in an old iron mine in Soudan, MN. Both detectors are exposed to a beam of muon neutrinos from the NuMI beamline, andmore » MINOS measures the fraction of muon neutrinos that disappear after traveling the 734 km between the two detectors. One can measure the atmospheric neutrino mass splitting and mixing angle by observing the energy-dependence of this muon neutrino disappearance. MINOS has made several prior measurements of these parameters. Here I describe recently-developed techniques used to enhance our sensitivity to the oscillation parameters, and I present the results obtained when they are applied to a dataset that is twice as large as has been previously analyzed. We measure the mass splitting Δm 23 2 = (2.32 -0.08 +0.12) x 10 -3 eV 2/c 4 and the mixing angle sin 2(2θ 32) > 0.90 at 90% C.L. These results comprise the world's best measurement of the atmospheric neutrino mass splitting. Alternative disappearance models are also tested. The neutrino decay hypothesis is disfavored at 7.2σ and the neutrino quantum decoherence hypothesis is disfavored at 9.0σ.« less

Neutrino physics with JUNO

NASA Astrophysics Data System (ADS)

An, Fengpeng; An, Guangpeng; An, Qi; Antonelli, Vito; Baussan, Eric; Beacom, John; Bezrukov, Leonid; Blyth, Simon; Brugnera, Riccardo; Buizza Avanzini, Margherita; Busto, Jose; Cabrera, Anatael; Cai, Hao; Cai, Xiao; Cammi, Antonio; Cao, Guofu; Cao, Jun; Chang, Yun; Chen, Shaomin; Chen, Shenjian; Chen, Yixue; Chiesa, Davide; Clemenza, Massimiliano; Clerbaux, Barbara; Conrad, Janet; D'Angelo, Davide; De Kerret, Hervé; Deng, Zhi; Deng, Ziyan; Ding, Yayun; Djurcic, Zelimir; Dornic, Damien; Dracos, Marcos; Drapier, Olivier; Dusini, Stefano; Dye, Stephen; Enqvist, Timo; Fan, Donghua; Fang, Jian; Favart, Laurent; Ford, Richard; Göger-Neff, Marianne; Gan, Haonan; Garfagnini, Alberto; Giammarchi, Marco; Gonchar, Maxim; Gong, Guanghua; Gong, Hui; Gonin, Michel; Grassi, Marco; Grewing, Christian; Guan, Mengyun; Guarino, Vic; Guo, Gang; Guo, Wanlei; Guo, Xin-Heng; Hagner, Caren; Han, Ran; He, Miao; Heng, Yuekun; Hsiung, Yee; Hu, Jun; Hu, Shouyang; Hu, Tao; Huang, Hanxiong; Huang, Xingtao; Huo, Lei; Ioannisian, Ara; Jeitler, Manfred; Ji, Xiangdong; Jiang, Xiaoshan; Jollet, Cécile; Kang, Li; Karagounis, Michael; Kazarian, Narine; Krumshteyn, Zinovy; Kruth, Andre; Kuusiniemi, Pasi; Lachenmaier, Tobias; Leitner, Rupert; Li, Chao; Li, Jiaxing; Li, Weidong; Li, Weiguo; Li, Xiaomei; Li, Xiaonan; Li, Yi; Li, Yufeng; Li, Zhi-Bing; Liang, Hao; Lin, Guey-Lin; Lin, Tao; Lin, Yen-Hsun; Ling, Jiajie; Lippi, Ivano; Liu, Dawei; Liu, Hongbang; Liu, Hu; Liu, Jianglai; Liu, Jianli; Liu, Jinchang; Liu, Qian; Liu, Shubin; Liu, Shulin; Lombardi, Paolo; Long, Yongbing; Lu, Haoqi; Lu, Jiashu; Lu, Jingbin; Lu, Junguang; Lubsandorzhiev, Bayarto; Ludhova, Livia; Luo, Shu; Lyashuk, Vladimir; Möllenberg, Randolph; Ma, Xubo; Mantovani, Fabio; Mao, Yajun; Mari, Stefano M.; McDonough, William F.; Meng, Guang; Meregaglia, Anselmo; Meroni, Emanuela; Mezzetto, Mauro; Miramonti, Lino; Mueller, Thomas; Naumov, Dmitry; Oberauer, Lothar; Ochoa-Ricoux, Juan Pedro; Olshevskiy, Alexander; Ortica, Fausto; Paoloni, Alessandro; Peng, Haiping; Peng, Jen-Chieh; Previtali, Ezio; Qi, Ming; Qian, Sen; Qian, Xin; Qian, Yongzhong; Qin, Zhonghua; Raffelt, Georg; Ranucci, Gioacchino; Ricci, Barbara; Robens, Markus; Romani, Aldo; Ruan, Xiangdong; Ruan, Xichao; Salamanna, Giuseppe; Shaevitz, Mike; Sinev, Valery; Sirignano, Chiara; Sisti, Monica; Smirnov, Oleg; Soiron, Michael; Stahl, Achim; Stanco, Luca; Steinmann, Jochen; Sun, Xilei; Sun, Yongjie; Taichenachev, Dmitriy; Tang, Jian; Tkachev, Igor; Trzaska, Wladyslaw; van Waasen, Stefan; Volpe, Cristina; Vorobel, Vit; Votano, Lucia; Wang, Chung-Hsiang; Wang, Guoli; Wang, Hao; Wang, Meng; Wang, Ruiguang; Wang, Siguang; Wang, Wei; Wang, Yi; Wang, Yi; Wang, Yifang; Wang, Zhe; Wang, Zheng; Wang, Zhigang; Wang, Zhimin; Wei, Wei; Wen, Liangjian; Wiebusch, Christopher; Wonsak, Björn; Wu, Qun; Wulz, Claudia-Elisabeth; Wurm, Michael; Xi, Yufei; Xia, Dongmei; Xie, Yuguang; Xing, Zhi-zhong; Xu, Jilei; Yan, Baojun; Yang, Changgen; Yang, Chaowen; Yang, Guang; Yang, Lei; Yang, Yifan; Yao, Yu; Yegin, Ugur; Yermia, Frédéric; You, Zhengyun; Yu, Boxiang; Yu, Chunxu; Yu, Zeyuan; Zavatarelli, Sandra; Zhan, Liang; Zhang, Chao; Zhang, Hong-Hao; Zhang, Jiawen; Zhang, Jingbo; Zhang, Qingmin; Zhang, Yu-Mei; Zhang, Zhenyu; Zhao, Zhenghua; Zheng, Yangheng; Zhong, Weili; Zhou, Guorong; Zhou, Jing; Zhou, Li; Zhou, Rong; Zhou, Shun; Zhou, Wenxiong; Zhou, Xiang; Zhou, Yeling; Zhou, Yufeng; Zou, Jiaheng

2016-03-01

The Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton multi-purpose underground liquid scintillator detector, was proposed with the determination of the neutrino mass hierarchy (MH) as a primary physics goal. The excellent energy resolution and the large fiducial volume anticipated for the JUNO detector offer exciting opportunities for addressing many important topics in neutrino and astro-particle physics. In this document, we present the physics motivations and the anticipated performance of the JUNO detector for various proposed measurements. Following an introduction summarizing the current status and open issues in neutrino physics, we discuss how the detection of antineutrinos generated by a cluster of nuclear power plants allows the determination of the neutrino MH at a 3-4σ significance with six years of running of JUNO. The measurement of antineutrino spectrum with excellent energy resolution will also lead to the precise determination of the neutrino oscillation parameters {{sin}}2{θ }12, {{Δ }}{m}212, and | {{Δ }}{m}{ee}2| to an accuracy of better than 1%, which will play a crucial role in the future unitarity test of the MNSP matrix. The JUNO detector is capable of observing not only antineutrinos from the power plants, but also neutrinos/antineutrinos from terrestrial and extra-terrestrial sources, including supernova burst neutrinos, diffuse supernova neutrino background, geoneutrinos, atmospheric neutrinos, and solar neutrinos. As a result of JUNO's large size, excellent energy resolution, and vertex reconstruction capability, interesting new data on these topics can be collected. For example, a neutrino burst from a typical core-collapse supernova at a distance of 10 kpc would lead to ˜5000 inverse-beta-decay events and ˜2000 all-flavor neutrino-proton ES events in JUNO, which are of crucial importance for understanding the mechanism of supernova explosion and for exploring novel phenomena such as collective neutrino oscillations

Neutrino Oscillations Physics

NASA Astrophysics Data System (ADS)

Fogli, Gianluigi

2005-06-01

We review the status of the neutrino oscillations physics, with a particular emphasis on the present knowledge of the neutrino mass-mixing parameters. We consider first the νμ → ντ flavor transitions of atmospheric neutrinos. It is found that standard oscillations provide the best description of the SK+K2K data, and that the associated mass-mixing parameters are determined at ±1σ (and NDF = 1) as: Δm2 = (2.6 ± 0.4) × 10-3 eV2 and sin 2 2θ = 1.00{ - 0.05}{ + 0.00} . Such indications, presently dominated by SK, could be strengthened by further K2K data. Then we point out that the recent data from the Sudbury Neutrino Observatory, together with other relevant measurements from solar and reactor neutrino experiments, in particular the KamLAND data, convincingly show that the flavor transitions of solar neutrinos are affected by Mikheyev-Smirnov-Wolfenstein (MSW) effects. Finally, we perform an updated analysis of two-family active oscillations of solar and reactor neutrinos in the standard MSW case.

Measurement of neutrino flux from neutrino-electron elastic scattering

DOE PAGES

Park, J.; Aliaga, L.; Altinok, O.; ...

2016-06-10

Muon-neutrino elastic scattering on electrons is an observable neutrino process whose cross section is precisely known. Consequently, a measurement of this process in an accelerator-based ν μ beam can improve the knowledge of the absolute neutrino flux impinging upon the detector; typically this knowledge is limited to ~10% due to uncertainties in hadron production and focusing. We also isolated a sample of 135±17 neutrino-electron elastic scattering candidates in the segmented scintillator detector of MINERvA, after subtracting backgrounds and correcting for efficiency. We show how this sample can be used to reduce the total uncertainty on the NuMI ν μ fluxmore » from 9% to 6%. Finally, our measurement provides a flux constraint that is useful to other experiments using the NuMI beam, and this technique is applicable to future neutrino beams operating at multi-GeV energies.« less

Measurement of neutrino flux from neutrino-electron elastic scattering

NASA Astrophysics Data System (ADS)

Park, J.; Aliaga, L.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Betancourt, M.; Bodek, A.; Bravar, A.; Budd, H.; Cai, T.; Carneiro, M. F.; Christy, M. E.; Chvojka, J.; da Motta, H.; Dytman, S. A.; Díaz, G. A.; Eberly, B.; Felix, J.; Fields, L.; Fine, R.; Gago, A. M.; Galindo, R.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Kleykamp, J.; Kordosky, M.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; Martinez Caicedo, D. A.; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman; Osta, J.; Paolone, V.; Patrick, C. E.; Perdue, G. N.; Rakotondravohitra, L.; Ramirez, M. A.; Ray, H.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Solano Salinas, C. J.; Tagg, N.; Tice, B. G.; Valencia, E.; Walton, T.; Wolcott, J.; Wospakrik, M.; Zavala, G.; Zhang, D.; Miner ν A Collaboration

2016-06-01

Muon-neutrino elastic scattering on electrons is an observable neutrino process whose cross section is precisely known. Consequently a measurement of this process in an accelerator-based νμ beam can improve the knowledge of the absolute neutrino flux impinging upon the detector; typically this knowledge is limited to ˜10 % due to uncertainties in hadron production and focusing. We have isolated a sample of 135 ±17 neutrino-electron elastic scattering candidates in the segmented scintillator detector of MINERvA, after subtracting backgrounds and correcting for efficiency. We show how this sample can be used to reduce the total uncertainty on the NuMI νμ flux from 9% to 6%. Our measurement provides a flux constraint that is useful to other experiments using the NuMI beam, and this technique is applicable to future neutrino beams operating at multi-GeV energies.

Tau-imaging in neurodegeneration.

PubMed

Bischof, Gérard N; Endepols, Heike; van Eimeren, Thilo; Drzezga, Alexander

2017-11-01

Pathological cerebral aggregations of proteins are suggested to play a crucial role in the development of neurodegenerative disorders. For example, aggregation of the protein ß-amyloid in form of extracellular amyloid-plaques as well as intraneuronal depositions of the protein tau in form of neurofibrillary tangles represent hallmarks of Alzheimer's disease (AD). Recently, novel tracers for in vivo molecular imaging of tau-aggregates in the brain have been introduced, complementing existing tracers for imaging amyloid-plaques. Available data on these novel tracers indicate that the subject of Tau-PET may be of considerable complexity. On the one hand this refers to the various forms of appearance of tau-pathology in different types of neurodegenerative disorders. On the other hand, a number of hurdles regarding validation of these tracers still need to be overcome with regard to comparability and standardization of the different tracers, observed off-target/non-specific binding and quantitative interpretation of the signal. These issues will have to be clarified before systematic clinical application of this exciting new methodological approach may become possible. Potential applications refer to early detection of neurodegeneration, differential diagnosis between tauopathies and non-tauopathies and specific patient selection and follow-up in therapy trials. Copyright © 2017. Published by Elsevier Inc.

Effect of collisions on neutrino flavor inhomogeneity in a dense neutrino gas

DOE PAGES

Cirigliano, Vincenzo; Paris, Mark W.; Shalgar, Shashank

2017-09-25

We investigate the stability, with respect to spatial inhomogeneity, of a two-dimensional dense neutrino gas. The system exhibits growth of seed inhomogeneity due to nonlinear coherent neutrino self-interactions. In the absence of incoherent collisional effects, we also observe a dependence of this instability growth rate on the neutrino mass spectrum: the normal neutrino mass hierarchy exhibits spatial instability over a larger range of neutrino number density compared to that of the inverted case. Furthermore, we consider the effect of elastic incoherent collisions of the neutrinos with a static background of heavy, nucleon-like scatterers. At small scales, the growth of flavormore » instability can be suppressed by collisions. At large length scales we find, perhaps surprisingly, that for inverted neutrino mass hierarchy incoherent collisions fail to suppress flavor instabilities, independent of the coupling strength.« less

Review: Tau in biofluids - relation to pathology, imaging and clinical features.

PubMed

Zetterberg, H

2017-04-01

Tau is a microtubule-binding protein that is important for the stability of neuronal axons. It is normally expressed within neurons and is also secreted into the brain interstitial fluid that communicates freely with cerebrospinal fluid (CSF) and, in a more restricted manner, blood via the glymphatic clearance system of the brain. In Alzheimer's disease (AD), neuroaxonal degeneration results in increased release of tau from neurons. Furthermore, tau is truncated and phosphorylated, which leads to aggregation of tau in neurofibrillary tangles of the proximal axoplasm. Neuroaxonal degeneration and tangle formation are reflected by increased concentrations of total tau (T-tau, measured using assays that detect most forms of tau) and phospho-tau (P-tau, measured using assays with antibodies specific to phosphorylated forms of tau). In AD CSF, both T-tau and P-tau concentrations are increased. In stroke and other CNS disorders with neuroaxonal injury but without tangles, T-tau is selectively increased, whereas P-tau concentration often stays normal. In tauopathies (diseases with both neurodegeneration and neurofibrillary tangles) other than AD, CSF T-tau and P-tau concentrations are typically unaltered, which is a puzzling result that warrants further investigation. In the current review, I discuss the association of T-tau and P-tau concentrations in body fluids with neuropathological changes, imaging findings and clinical features in AD and other CNS diseases. © 2017 British Neuropathological Society.

Neutrino-oscillation search with cosmic-ray neutrinos

NASA Astrophysics Data System (ADS)

Ayres, D. S.; Cortez, B.; Gaisser, T. K.; Mann, A. K.; Shrock, R. E.; Sulak, L. R.

1984-03-01

A sensitive search for neutrino oscillations involving νe, νμ, and ντ may be provided by measurements of the ratio of the total interaction rates of upward- and downward-going cosmic-ray neutrinos within a massive (~10 kton) detector. Assuming mixing between all pairs of νe, νμ, and ντ, the experiment is capable of observing time-averaged probabilities t and t of magnitude set by mixing strengths corresponding to, e.g., the d- to s-quark mixing strength, and of reaching the limit Δm2ij≡|mi2-mj2|~10-4 eV2, where mi, and mj are neutrino mass eigenstates, and Peτ and Pμτ are the probabilities for νe and νμ, respectively, to oscillate into ντ after traversing a distance L~ diameter of the Earth. Possible ambiguities may be resolved through comparison of the ratios NeNμ for the upward- and downward-going neutrinos.

Neutrino Physics at Fermilab

ScienceCinema

Saoulidou, Niki

2017-12-09

Neutrino oscillations provide the first evidence for physics beyond the Standard Model. I will briefly overview the neutrino "hi-story", describing key discoveries over the past decades that shaped our understanding of neutrinos and their behavior. Fermilab was, is and hopefully will be at the forefront of the accelerator neutrino experiments.  NuMI, the most powerful accelerator neutrino beam in the world has ushered us into the era of precise measurements. Its further upgrades may give a chance to tackle the remaining mysteries of the neutrino mass hierarchy and possible CP violation.

Search for sterile neutrinos in gallium experiments with artificial neutrino sources

NASA Astrophysics Data System (ADS)

Gavrin, V. N.; Cleveland, B. T.; Gorbachev, V. V.; Ibragimova, T. V.; Kalikhov, A. V.; Kozlova, Yu. P.; Mirmov, I. N.; Shikhin, A. A.; Veretenkin, E. P.

2017-11-01

The possibility of the BEST experiment on electron neutrino disappearance with intense artificial sources of electron neutrino 51Cr is considered. BEST has the great potential to search for transitions of active neutrinos to sterile states with Δ m 2 ˜ 1 eV2 and to set the limits on short baseline electron neutrino disappearance oscillation parameters. The possibility of the further constraints the oscillation parameters region with using 65Zn source is discussed.

Neutrino physics with JUNO

DOE Office of Scientific and Technical Information (OSTI.GOV)

An, Fengpeng; An, Guangpeng; An, Qi

The Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton multi-purpose underground liquid scintillator detector, was proposed with the determination of the neutrino mass hierarchy (MH) as a primary physics goal. The excellent energy resolution and the large fiducial volume anticipated for the JUNO detector offer exciting opportunities for addressing many important topics in neutrino and astro-particle physics. In this document, we present the physics motivations and the anticipated performance of the JUNO detector for various proposed measurements. Following an introduction summarizing the current status and open issues in neutrino physics, we discuss how the detection of antineutrinos generated by a cluster of nuclear power plants allows the determination of the neutrino MH at a 3–4σ significance with six years of running of JUNO. The measurement of antineutrino spectrum with excellent energy resolution will also lead to the precise determination of the neutrino oscillation parametersmore » $${\\mathrm{sin}}^{2}{\\theta }_{12}$$, $${\\rm{\\Delta }}{m}_{21}^{2}$$, and $$| {\\rm{\\Delta }}{m}_{{ee}}^{2}| $$ to an accuracy of better than 1%, which will play a crucial role in the future unitarity test of the MNSP matrix. The JUNO detector is capable of observing not only antineutrinos from the power plants, but also neutrinos/antineutrinos from terrestrial and extra-terrestrial sources, including supernova burst neutrinos, diffuse supernova neutrino background, geoneutrinos, atmospheric neutrinos, and solar neutrinos. As a result of JUNO's large size, excellent energy resolution, and vertex reconstruction capability, interesting new data on these topics can be collected. For example, a neutrino burst from a typical core-collapse supernova at a distance of 10 kpc would lead to ~5000 inverse-beta-decay events and ~2000 all-flavor neutrino–proton ES events in JUNO, which are of crucial importance for understanding the mechanism of supernova explosion and

Neutrino physics with JUNO

DOE PAGES

An, Fengpeng; An, Guangpeng; An, Qi; ...

2016-02-10

The Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton multi-purpose underground liquid scintillator detector, was proposed with the determination of the neutrino mass hierarchy (MH) as a primary physics goal. The excellent energy resolution and the large fiducial volume anticipated for the JUNO detector offer exciting opportunities for addressing many important topics in neutrino and astro-particle physics. In this document, we present the physics motivations and the anticipated performance of the JUNO detector for various proposed measurements. Following an introduction summarizing the current status and open issues in neutrino physics, we discuss how the detection of antineutrinos generated by a cluster of nuclear power plants allows the determination of the neutrino MH at a 3–4σ significance with six years of running of JUNO. The measurement of antineutrino spectrum with excellent energy resolution will also lead to the precise determination of the neutrino oscillation parametersmore » $${\\mathrm{sin}}^{2}{\\theta }_{12}$$, $${\\rm{\\Delta }}{m}_{21}^{2}$$, and $$| {\\rm{\\Delta }}{m}_{{ee}}^{2}| $$ to an accuracy of better than 1%, which will play a crucial role in the future unitarity test of the MNSP matrix. The JUNO detector is capable of observing not only antineutrinos from the power plants, but also neutrinos/antineutrinos from terrestrial and extra-terrestrial sources, including supernova burst neutrinos, diffuse supernova neutrino background, geoneutrinos, atmospheric neutrinos, and solar neutrinos. As a result of JUNO's large size, excellent energy resolution, and vertex reconstruction capability, interesting new data on these topics can be collected. For example, a neutrino burst from a typical core-collapse supernova at a distance of 10 kpc would lead to ~5000 inverse-beta-decay events and ~2000 all-flavor neutrino–proton ES events in JUNO, which are of crucial importance for understanding the mechanism of supernova explosion and

The ideal neutrino beams

NASA Astrophysics Data System (ADS)

Lindroos, Mats

2009-06-01

The advance in neutrino oscillation physics is driven by the availability of well characterized and high flux neutrino beams. The three present options for the next generation neutrino oscillation facility are super beams, neutrino factories and beta-beams. A super-beam is a very high intensity classical neutrino beam generated by protons impinging on a target where the neutrinos are generated by the secondary particles decaying in a tunnel down streams of the target. In a neutrino factory the neutrinos are generated from muons decaying in a storage ring with long straight sections pointing towards the detectors. In a beta-beam the neutrinos are also originating from decay in a storage ring but the decaying particles are radioactive ions rather than muons. I will in this presentation review the three options and discuss the pros and cons of each. The present joint design effort for a future high intensity neutrino oscillation in Europe within a common EU supported design study, EURONU, will also be presented. The design study will explore the physics reach, the detectors, the feasibility, the safety issues and the cost for each of the options so that the the community can take a decision on what to build when the facilities presently under exploitation and construction have to be replaced.

Evidence for neutrino oscillations in the Sudbury Neutrino Observatory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marino, Alysia Diane

2004-01-01

The Sudbury Neutrino Observatory (SNO) is a large-volume heavy water Cerenkov detector designed to resolve the solar neutrino problem. SNO observes charged-current interactions with electron neutrinos, neutral-current interactions with all active neutrinos, and elastic-scattering interactions primarily with electron neutrinos with some sensitivity to other flavors. This dissertation presents an analysis of the solar neutrino flux observed in SNO in the second phase of operation, while ~2 tonnes of salt (NaCl) were dissolved in the heavy water. The dataset here represents 391 live days of data. Only the events above a visible energy threshold of 5.5 MeV and inside a fiducial volume within 550 cm of the center of the detector are studied. The neutrino flux observed via the charged-current interaction is [1.71 ± 0.065(stat.)±more » $$0.065\\atop{0.068}$$(sys.)±0.02(theor.)] x 10 6cm -2s -1, via the elastic-scattering interaction is [2.21±0.22(stat.)±$$0.12\\atop{0.11}$$(sys.)±0.01(theor.)] x 10 6cm -2s -1, and via the neutral-current interaction is [5.05±0.23(stat.)±$$0.31\\atop{0.37}$$(sys.)±0.06(theor.)] x 10 6cm -2s -1. The electron-only flux seen via the charged-current interaction is more than 7σ below the total active flux seen via the neutral-current interaction, providing strong evidence that neutrinos are undergoing flavor transformation as they travel from the core of the Sun to the Earth. The most likely origin of the flavor transformation is matter-induced flavor oscillation.« less

Evaluation of chromatic cues for trapping Bactrocera tau.

PubMed

Li, Lei; Ma, Huabo; Niu, Liming; Han, Dongyin; Zhang, Fangping; Chen, Junyu; Fu, Yueguan

2017-01-01

Trapping technology based on chromatic cues is an important strategy in controlling Tephritidae (fruit flies). The objectives of this present study were to evaluate the preference of Bactrocera tau for different chromatic cues, and to explore an easy method to print and reproduce coloured paper. Chromatic cues significantly affected the preference of adult B. tau. Wavelengths in the 515-604 nm range were the suitable wavelengths for trapping B. tau. Different-day-old B. tau had different colour preferences. Virtual wavelengths of 595 nm (yellow) and 568 nm (yellowish green) were the optimum wavelengths for trapping 5-7-day-old B. tau and 30-32-day-old B. tau respectively. The trap type and height significantly influenced B. tau attraction efficiency. The number of B. tau on coloured traps hung perpendicular to plant rows was not significantly higher than the number on traps hung parallel to plant rows. The quantisation of colour on the basis of Bruton's wavelength to RGB function can serve as an alternative method for printing and reproducing coloured paper, but a corrected equation should be established between the theoretical wavelength and actual wavelength of coloured paper. Results show that a compound paper coloured yellow (595 nm) and yellowish green (568 nm) installed at 60 and 90 cm above the ground shows the maximum effect for trapping B. tau. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

Experimental Neutrino Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkes, Richard Jeffrey

The University of Washington (UW) HEP neutrino group performed experimental research on the physics of neutrinos, using the capabilities offered by the T2K Experiment and the Super-Kamiokande Neutrino Observatory. The UW group included senior investigator R. J. Wilkes, two PhD students, four MS degree students, and a research engineer, all of whom are members of the international scientific collaborations for T2K and Super-Kamiokande. During the period of support, within T2K we pursued new precision studies sensitive to new physics, going beyond the limits of current measurements of the fundamental neutrino oscillation parameters (mass differences and mixing angles). We began effortsmore » to measure (or significantly determine the absence of) 1 the CP-violating phase parameter δCP and determine the neutrino mass hierarchy. Using the Super-Kamiokande (SK) detector we pursued newly increased precision in measurement of neutrino oscillation parameters with atmospheric neutrinos, and extended the current reach in searches for proton decay, in addition to running the most sensitive supernova watch instrument [Scholberg 2012], performing other astrophysical neutrino studies, and analyzing beam-induced events from T2K. Overall, the research addressed central questions in the field of particle physics. It included the training of graduate students (both PhD and professional MS degree students), and postdoctoral researchers. Undergraduate students also participated as laboratory assistants.« less

Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation.

PubMed

Li, Xiao-Hong; Xie, Jia-Zhao; Jiang, Xia; Lv, Bing-Ling; Cheng, Xiang-Shu; Du, Lai-Ling; Zhang, Jia-Yu; Wang, Jian-Zhi; Zhou, Xin-Wen

2012-12-01

The hyperphosphorylated tau is a major protein component of neurofibrillary tangle, which is one of hallmarks of Alzheimer's disease (AD). While the level of methylglyoxal (MG) is significantly increased in the AD brains, the role of MG in tau phosphorylation is still not reported. Here, we found that MG could induce tau hyperphosphorylation at multiple AD-related sites in neuroblastoma 2a cells under maintaining normal cell viability. MG treatment increased the level of advanced glycation end products (AGEs) and the receptor of AGEs (RAGE). Glycogen synthesis kinase-3β (GSK-3β) and p38 MAPK were activated, whereas the level and activity of JNK, Erk1/2, cdk5, and PP2A were not altered after MG treatment. Simultaneous inhibition of GSK-3β or p38 attenuated the MG-induced tau hyperphosphorylation. Aminoguanidine, a blocker of AGEs formation, could effectively reverse the MG-induced tau hyperphosphorylation. These data suggest that MG induces AD-like tau hyperphosphorylation through AGEs formation involving RAGE up-regulation and GSK-3β activation and p38 activation is also partially involved in MG-induced tau hyperphosphorylation. Thus, targeting MG may be a promising therapeutic strategy to prevent AD-like tau hyperphosphorylation.

Neutrino oscillation studies with reactors

PubMed Central

Vogel, P.; Wen, L.J.; Zhang, C.

2015-01-01

Nuclear reactors are one of the most intense, pure, controllable, cost-effective and well-understood sources of neutrinos. Reactors have played a major role in the study of neutrino oscillations, a phenomenon that indicates that neutrinos have mass and that neutrino flavours are quantum mechanical mixtures. Over the past several decades, reactors were used in the discovery of neutrinos, were crucial in solving the solar neutrino puzzle, and allowed the determination of the smallest mixing angle θ13. In the near future, reactors will help to determine the neutrino mass hierarchy and to solve the puzzling issue of sterile neutrinos. PMID:25913819

Neutrino oscillation studies with reactors

DOE PAGES

Vogel, P.; Wen, L.J.; Zhang, C.

2015-04-27

Nuclear reactors are one of the most intense, pure, controllable, cost-effective and well-understood sources of neutrinos. Reactors have played a major role in the study of neutrino oscillations, a phenomenon that indicates that neutrinos have mass and that neutrino flavours are quantum mechanical mixtures. Over the past several decades, reactors were used in the discovery of neutrinos, were crucial in solving the solar neutrino puzzle, and allowed the determination of the smallest mixing angle θ 13. In the near future, reactors will help to determine the neutrino mass hierarchy and to solve the puzzling issue of sterile neutrinos.

Neutrino oscillation studies with reactors.

PubMed

Vogel, P; Wen, L J; Zhang, C

2015-04-27

Nuclear reactors are one of the most intense, pure, controllable, cost-effective and well-understood sources of neutrinos. Reactors have played a major role in the study of neutrino oscillations, a phenomenon that indicates that neutrinos have mass and that neutrino flavours are quantum mechanical mixtures. Over the past several decades, reactors were used in the discovery of neutrinos, were crucial in solving the solar neutrino puzzle, and allowed the determination of the smallest mixing angle θ13. In the near future, reactors will help to determine the neutrino mass hierarchy and to solve the puzzling issue of sterile neutrinos.

Proteopathic tau seeding predicts tauopathy in vivo

PubMed Central

Holmes, Brandon B.; Furman, Jennifer L.; Mahan, Thomas E.; Yamasaki, Tritia R.; Mirbaha, Hilda; Eades, William C.; Belaygorod, Larisa; Cairns, Nigel J.; Holtzman, David M.; Diamond, Marc I.

2014-01-01

Transcellular propagation of protein aggregates, or proteopathic seeds, may drive the progression of neurodegenerative diseases in a prion-like manner. In tauopathies such as Alzheimer’s disease, this model predicts that tau seeds propagate pathology through the brain via cell–cell transfer in neural networks. The critical role of tau seeding activity is untested, however. It is unknown whether seeding anticipates and correlates with subsequent development of pathology as predicted for a causal agent. One major limitation has been the lack of a robust assay to measure proteopathic seeding activity in biological specimens. We engineered an ultrasensitive, specific, and facile FRET-based flow cytometry biosensor assay based on expression of tau or synuclein fusions to CFP and YFP, and confirmed its sensitivity and specificity to tau (∼300 fM) and synuclein (∼300 pM) fibrils. This assay readily discriminates Alzheimer’s disease vs. Huntington's disease and aged control brains. We then carried out a detailed time-course study in P301S tauopathy mice, comparing seeding activity versus histological markers of tau pathology, including MC1, AT8, PG5, and Thioflavin S. We detected robust seeding activity at 1.5 mo, >1 mo before the earliest histopathological stain. Proteopathic tau seeding is thus an early and robust marker of tauopathy, suggesting a proximal role for tau seeds in neurodegeneration. PMID:25261551

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.

PubMed

Calafate, Sara; Buist, Arjan; Miskiewicz, Katarzyna; Vijayan, Vinoy; Daneels, Guy; de Strooper, Bart; de Wit, Joris; Verstreken, Patrik; Moechars, Diederik

2015-05-26

Accumulation of insoluble Tau protein aggregates and stereotypical propagation of Tau pathology through the brain are common hallmarks of tauopathies, including Alzheimer's disease (AD). Propagation of Tau pathology appears to occur along connected neurons, but whether synaptic contacts between neurons are facilitating propagation has not been demonstrated. Using quantitative in vitro models, we demonstrate that, in parallel to non-synaptic mechanisms, synapses, but not merely the close distance between the cells, enhance the propagation of Tau pathology between acceptor hippocampal neurons and Tau donor cells. Similarly, in an artificial neuronal network using microfluidic devices, synapses and synaptic activity are promoting neuronal Tau pathology propagation in parallel to the non-synaptic mechanisms. Our work indicates that the physical presence of synaptic contacts between neurons facilitate Tau pathology propagation. These findings can have implications for synaptic repair therapies, which may turn out to have adverse effects by promoting propagation of Tau pathology. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Measurement of the absolute branching fraction of Ds+ --> tau+ nutau decay.

PubMed

Ecklund, K M; Love, W; Savinov, V; Lopez, A; Mendez, H; Ramirez, J; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Khalil, S; Li, J; Mountain, R; Nisar, S; Randrianarivony, K; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Rademacker, J; Asner, D M; Edwards, K W; Naik, P; Reed, J; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P; Eisenstein, B I; Karliner, I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Libby, J; Powell, A; Wilkinson, G

2008-04-25

Using a sample of tagged D(s)(+) decays collected near the D(s)(*+/-)D(s)(-/+) peak production energy in e(+)e(-) collisions with the CLEO-c detector, we study the leptonic decay D(s)(+)-->tau(+)nu(tau) via the decay channel tau(+)-->e(+)nu(e)nu(tau). We measure B(D(s)(+)-->tau(+)nu(tau))=(6.17+/-0.71+/-0.34)%, where the first error is statistical and the second systematic. Combining this result with our measurements of D(s)(+)-->mu(+)nu(mu) and D(s)(+)-->tau(+)nu(tau) (via tau(+)-->pi(+)nu(tau)), we determine f(D(s))=(274+/-10+/-5) MeV.

Home - Deep Underground Neutrino ExperimentDeep Underground Neutrino

Science.gov Websites

understanding of neutrinos and their role in the universe. DUNE prototype detectors are under construction at understanding of neutrinos and their role in the universe. DUNE_Forces_011116_FINAL Unification of Forces With

Relation between the neutrino flux from Centaurus A and the associated diffuse neutrino flux

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koers, Hylke B. J.; Tinyakov, Peter; Institute for Nuclear Research, 60th October Anniversary Prospect 7a, 117312, Moscow

2008-10-15

Based on recent results obtained by the Pierre Auger Observatory (PAO), it has been hypothesized that Centaurus A (Cen A) is a source of ultrahigh-energy cosmic rays (UHECRs) and associated neutrinos. We point out that the diffuse neutrino flux may be used to constrain the source model if one assumes that the ratio between the UHECR and neutrino fluxes outputted by Cen A is representative for other sources. Under this assumption we investigate the relation between the neutrino flux from Cen A and the diffuse neutrino flux. Assuming furthermore that Cen A is the source of two UHECR events observedmore » by PAO, we estimate the all-sky diffuse neutrino flux to be {approx}200-5000 times larger than the neutrino flux from Cen A. As a result, the diffuse neutrino fluxes associated with some of the recently proposed models of UHECR-related neutrino production in Cen A are above existing limits. Regardless of the underlying source model, our results indicate that the detection of neutrinos from Cen A without the accompanying diffuse flux would mean that Cen A is an exceptionally efficient neutrino source.« less

Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers

PubMed Central

Mouzon, Benoit; Algamal, Moustafa; Leary, Paige; Lynch, Cillian; Abdullah, Laila; Evans, James; Mullan, Michael; Bachmeier, Corbin; Stewart, William; Crawford, Fiona

2016-01-01

Exposure to repetitive mild traumatic brain injury (mTBI) is a risk factor for chronic traumatic encephalopathy, which is characterized by patchy deposition of hyperphosphorylated tau aggregates in neurons and astrocytes at the depths of cortical sulci. We developed an mTBI paradigm to explore effects of repetitive concussive-type injury over several months in mice with a human tau genetic background (hTau). Two injuries were induced in the hTau mice weekly over a period of 3 or 4 months and the effects were compared with those in noninjured sham animals. Behavioral and in vivo measures and detailed neuropathological assessments were conducted 6 months after the first injury. Our data confirm impairment in cerebral blood flow and white matter damage. This was accompanied by a 2-fold increase in total tau levels and mild increases in tau oligomers/conformers and pTau (Thr231) species in brain gray matter. There was no evidence of neurofibrillary/astroglial tangles, neuropil threads, or perivascular foci of tau immunoreactivity. There were neurobehavioral deficits (ie, disinhibition and impaired cognitive performance) in the mTBI animals. These data support the relevance of this new mTBI injury model for studying the consequences of chronic repetitive mTBI in humans, and the role of tau in TBI. PMID:27251042

Experimental Neutrino Physics: Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, Charles E.; Maricic, Jelena

2012-09-05

Experimental studies of neutrino properties, with particular emphasis on neutrino oscillation, mass and mixing parameters. This research was pursued by means of underground detectors for reactor anti-neutrinos, measuring the flux and energy spectra of the neutrinos. More recent investigations have been aimed and developing detector technologies for a long-baseline neutrino experiment (LBNE) using a neutrino beam from Fermilab.

Antisense reduction of tau in adult mice protects against seizures.

PubMed

DeVos, Sarah L; Goncharoff, Dustin K; Chen, Guo; Kebodeaux, Carey S; Yamada, Kaoru; Stewart, Floy R; Schuler, Dorothy R; Maloney, Susan E; Wozniak, David F; Rigo, Frank; Bennett, C Frank; Cirrito, John R; Holtzman, David M; Miller, Timothy M

2013-07-31

Tau, a microtubule-associated protein, is implicated in the pathogenesis of Alzheimer's Disease (AD) in regard to both neurofibrillary tangle formation and neuronal network hyperexcitability. The genetic ablation of tau substantially reduces hyperexcitability in AD mouse lines, induced seizure models, and genetic in vivo models of epilepsy. These data demonstrate that tau is an important regulator of network excitability. However, developmental compensation in the genetic tau knock-out line may account for the protective effect against seizures. To test the efficacy of a tau reducing therapy for disorders with a detrimental hyperexcitability profile in adult animals, we identified antisense oligonucleotides that selectively decrease endogenous tau expression throughout the entire mouse CNS--brain and spinal cord tissue, interstitial fluid, and CSF--while having no effect on baseline motor or cognitive behavior. In two chemically induced seizure models, mice with reduced tau protein had less severe seizures than control mice. Total tau protein levels and seizure severity were highly correlated, such that those mice with the most severe seizures also had the highest levels of tau. Our results demonstrate that endogenous tau is integral for regulating neuronal hyperexcitability in adult animals and suggest that an antisense oligonucleotide reduction of tau could benefit those with epilepsy and perhaps other disorders associated with tau-mediated neuronal hyperexcitability.

The Deep Underground Neutrino Experiment: The precision era of neutrino physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kemp, E.

The last decade was remarkable for neutrino physics. In particular, the phenomenon of neutrino flavor oscillations has been firmly established by a series of independent measurements. All parameters of the neutrino mixing are now known, and we have the elements to plan a judicious exploration of new scenarios that are opened by these recent advances. With precise measurements, we can test the three-neutrino paradigm, neutrino mass hierarchy, and charge conjugation parity (CP) asymmetry in the lepton sector. The future long-baseline experiments are considered to be a fundamental tool to deepen our knowledge of electroweak interactions. The Deep Underground Neutrino Experimentmore » (DUNE) will detect a broadband neutrino beam from Fermilab in an underground massive liquid argon time-projection chamber at an L/E of about 103 km GeV-1 to reach good sensitivity for CP-phase measurements and the determination of the mass hierarchy. The dimensions and the depth of the far detector also create an excellent opportunity to look for rare signals like proton decay to study violation of the baryonic number, as well as supernova neutrino bursts, broadening the scope of the experiment to astrophysics and associated impacts in cosmology. In this paper, we discuss the physics motivations and the main experimental features of the DUNE project required to reach its scientific goals.« less

High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology.

PubMed

Gratuze, Maud; Julien, Jacinthe; Morin, Françoise; Calon, Frédéric; Hébert, Sébastien S; Marette, André; Planel, Emmanuel

2016-11-01

Aggregates of hyperphosphorylated tau protein are a pathological hallmark of Alzheimer's disease (AD). The origin of AD is multifactorial, and many metabolic disorders originating from overconsumption of fat, cholesterol, and sugar are associated with higher risk of AD later in life. However, the effects of fat, cholesterol, and sugar overconsumption on tau pathology in AD remain controversial. Using the hTau mice, a model of AD-like tau pathology, we assessed the effects of high-fat, high-cholesterol, and/or high-sugar diets on tau pathogenesis. Surprisingly, we found no effects of these compounds, even combined, on tau phosphorylation, O-GlcNAcylation, splicing, cleavage, and aggregation, suggesting that their overconsumption does not seem to worsen tau pathology in these mice. Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.

Muons and neutrinos

NASA Technical Reports Server (NTRS)

Stanev, T.

1986-01-01

The first generation of large and precise detectors, some initially dedicated to search for nucleon decay has accumulated significant statistics on neutrinos and high-energy muons. A second generation of even better and bigger detectors are already in operation or in advanced construction stage. The present set of experimental data on muon groups and neutrinos is qualitatively better than several years ago and the expectations for the following years are high. Composition studies with underground muon groups, neutrino detection, and expected extraterrestrial neutrino fluxes are discussed.

Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology*

PubMed Central

Gu, Jiaping; Congdon, Erin E.; Sigurdsson, Einar M.

2013-01-01

Aggregated Tau proteins are hallmarks of Alzheimer disease and other tauopathies. Recent studies from our group and others have demonstrated that both active and passive immunizations reduce Tau pathology and prevent cognitive decline in transgenic mice. To determine the efficacy and safety of targeting the prominent 396/404 region, we developed two novel monoclonal antibodies (mAbs) with distinct binding profiles for phospho and non-phospho epitopes. The two mAbs significantly reduced hyperphosphorylated soluble Tau in long term brain slice cultures without apparent toxicity, suggesting the therapeutic importance of targeting the 396/404 region. In mechanistic studies, we found that neurons were the primary cell type that internalized the mAbs, whereas a small amount of mAbs was taken up by microglia cells. Within neurons, the two mAbs were highly colocalized with distinct pathological Tau markers, indicating their affinity toward different stages or forms of pathological Tau. Moreover, the mAbs were largely co-localized with endosomal/lysosomal markers, and partially co-localized with autophagy pathway markers. Additionally, the Fab fragments of the mAbs were able to enter neurons, but unlike the whole antibodies, the fragments were not specifically localized in pathological neurons. In summary, our Tau mAbs were safe and efficient to clear pathological Tau in a brain slice model. Fc-receptor-mediated endocytosis and the endosome/autophagosome/lysosome system are likely to have a critical role in antibody-mediated clearance of Tau pathology. PMID:24089520

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation*

PubMed Central

Crowe, Alex; James, Michael J.; Lee, Virginia M.-Y.; Smith, Amos B.; Trojanowski, John Q.; Ballatore, Carlo; Brunden, Kurt R.

2013-01-01

Alzheimer disease and several other neurodegenerative disorders are characterized by the accumulation of intraneuronal fibrils comprised of the protein Tau. Tau is normally a soluble protein that stabilizes microtubules, with splice isoforms that contain either three (3-R) or four (4-R) microtubule binding repeats. The formation of Tau fibrils is thought to result in neuronal damage, and inhibitors of Tau fibrillization may hold promise as therapeutic agents. The process of Tau fibrillization can be replicated in vitro, and a number of small molecules have been identified that inhibit Tau fibril formation. However, little is known about how these molecules affect Tau fibrillization. Here, we examined the mechanism by which the previously described aminothieno pyridazine (ATPZ) series of compounds inhibit Tau fibrillization. Active ATPZs were found to promote the oxidation of the two cysteine residues within 4-R Tau by a redox cycling mechanism, resulting in the formation of a disulfide-containing compact monomer that was refractory to fibrillization. Moreover, the ATPZs facilitated intermolecular disulfide formation between 3-R Tau monomers, leading to dimers that were capable of fibrillization. The ATPZs also caused cysteine oxidation in molecules unrelated to Tau. Interestingly, methylene blue, an inhibitor of Tau fibrillization under evaluation in Alzheimer disease clinical trials, caused a similar oxidation of cysteines in Tau and other molecules. These findings reveal that the ATPZs and methylene blue act by a mechanism that may affect their viability as potential therapeutic agents. PMID:23443659

INVESTIGATING PLANET FORMATION IN CIRCUMSTELLAR DISKS: CARMA OBSERVATIONS OF RY Tau AND DG Tau

DOE Office of Scientific and Technical Information (OSTI.GOV)

Isella, Andrea; Carpenter, John M.; Sargent, Anneila I., E-mail: isella@astro.caltech.ed

2010-05-10

We present CARMA observations of the thermal dust emission from the circumstellar disks around the young stars RY Tau and DG Tau at wavelengths of 1.3 mm and 2.8 mm. The angular resolution of the maps is as high as 0.''15, or 20 AU at the distance of the Taurus cloud, which is a factor of 2 higher than has been achieved to date at these wavelengths. The unprecedented detail of the resulting disk images enables us to address three important questions related to the formation of planets. (1) What is the radial distribution of the circumstellar dust? (2) Doesmore » the dust emission show any indication of gaps that might signify the presence of (proto-)planets? (3) Do the dust properties depend on the orbital radius? We find that modeling the disk surface density in terms of either a classical power law or the similarity solution for viscous disk evolution reproduces the observations well. Both models constrain the surface density between 15 and 50 AU to within 30% for a given dust opacity. Outside this range, the densities inferred from the two models differ by almost an order of magnitude. The 1.3 mm image from RY Tau shows two peaks separated by 0.''2 with a decline in the dust emission toward the stellar position, which is significant at about 2{sigma}-4{sigma}. For both RY Tau and DG Tau, the dust emission at radii larger than 15 AU displays no significant deviation from an unperturbed viscous disk model. In particular, no radial gaps in the dust distribution are detected. Under reasonable assumptions, we exclude the presence of planets more massive than 5 M{sub J} orbiting either star at distances between about 10 and 60 AU, unless such a planet is so young that there has been insufficient time to open a gap in the disk surface density. The radial variation of the dust opacity slope, {beta}, was investigated by comparing the 1.3 mm and 2.8 mm observations. We find mean values of {beta} of 0.5 and 0.7 for DG Tau and RY Tau, respectively. Variations in {beta

Sterile neutrino dark matter production

NASA Astrophysics Data System (ADS)

Gorbunov, Dmitry

2017-10-01

Sterile neutrinos provide active neutrinos with masses and mixing, and hence is one of the well-motivated candidate for dark matter. We discuss the sterile neutrino production mechanisms operating in the early Universe and show that additional scalar coupled to sterile neutrino can significantly change the situation, making moderate sterile-neutrino mixing and small sterile neutrino masses consistent with current cosmological and astrophysical bounds. Further searches for a narrow line in galactic X-rays and even direct searches for keV-scale sterile neutrinos in particle physics experiments can probe the suggested setup.

Charged Cosmic Rays and Neutrinos

NASA Astrophysics Data System (ADS)

Kachelrieß, M.

2013-04-01

High-energy neutrino astronomy has grown up, with IceCube as one of its main experiments having sufficient sensitivity to test "vanilla" models of astrophysical neutrinos. I review predictions of neutrino fluxes as well as the status of cosmic ray physics. I comment also briefly on an improvement of the Fermi-LAT limit for cosmogenic neutrinos and on the two neutrino events presented by IceCube first at "Neutrino 2012".

An optimization of the FPGA trigger based on the artificial neural network for a detection of neutrino-origin showers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szadkowski, Zbigniew; Glas, Dariusz; Pytel, Krzysztof

Observations of ultra-high energy neutrinos became a priority in experimental astro-particle physics. Up to now, the Pierre Auger Observatory did not find any candidate on a neutrino event. This imposes competitive limits to the diffuse flux of ultra-high energy neutrinos in the EeV range and above. A very low rate of events potentially generated by neutrinos is a significant challenge for a detection technique and requires both sophisticated algorithms and high-resolution hardware. A trigger based on a artificial neural network was implemented into the Cyclone{sup R} V E FPGA 5CEFA9F31I7. The prototype Front-End boards for Auger-Beyond-2015 with Cyclone{sup R} Vmore » E can test the neural network algorithm in real pampas conditions in 2015. Showers for muon and tau neutrino initiating particles on various altitudes, angles and energies were simulated in CORSICA and Offline platforms giving pattern of ADC traces in Auger water Cherenkov detectors. The 3-layer 12-10-1 neural network was taught in MATLAB by simulated ADC traces according the Levenberg-Marquardt algorithm. Results show that a probability of a ADC traces generation is very low due to a small neutrino cross-section. Nevertheless, ADC traces, if occur, for 1-10 EeV showers are relatively short and can be analyzed by 16-point input algorithm. For 100 EeV range traces are much longer, but with significantly higher amplitudes, which can be detected by standard threshold algorithms. We optimized the coefficients from MATLAB to get a maximal range of potentially registered events and for fixed-point FPGA processing to minimize calculation errors. Currently used Front-End boards based on no-more produced ACEXR PLDs and obsolete Cyclone{sup R} FPGAs allow an implementation of relatively simple threshold algorithms for triggers. New sophisticated trigger implemented in Cyclone{sup R} V E FPGAs with large amount of DSP blocks, embedded memory running with 120 - 160 MHz sampling may support to discover neutrino

Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers.

PubMed

Ojo, Joseph O; Mouzon, Benoit; Algamal, Moustafa; Leary, Paige; Lynch, Cillian; Abdullah, Laila; Evans, James; Mullan, Michael; Bachmeier, Corbin; Stewart, William; Crawford, Fiona

2016-07-01

Exposure to repetitive mild traumatic brain injury (mTBI) is a risk factor for chronic traumatic encephalopathy, which is characterized by patchy deposition of hyperphosphorylated tau aggregates in neurons and astrocytes at the depths of cortical sulci. We developed an mTBI paradigm to explore effects of repetitive concussive-type injury over several months in mice with a human tau genetic background (hTau). Two injuries were induced in the hTau mice weekly over a period of 3 or 4 months and the effects were compared with those in noninjured sham animals. Behavioral and in vivo measures and detailed neuropathological assessments were conducted 6 months after the first injury. Our data confirm impairment in cerebral blood flow and white matter damage. This was accompanied by a 2-fold increase in total tau levels and mild increases in tau oligomers/conformers and pTau (Thr231) species in brain gray matter. There was no evidence of neurofibrillary/astroglial tangles, neuropil threads, or perivascular foci of tau immunoreactivity. There were neurobehavioral deficits (ie, disinhibition and impaired cognitive performance) in the mTBI animals. These data support the relevance of this new mTBI injury model for studying the consequences of chronic repetitive mTBI in humans, and the role of tau in TBI. © 2016 American Association of Neuropathologists, Inc. All rights reserved.

DEEP UNDERGROUND NEUTRINO EXPERIMENT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, Robert J.

2016-03-03

The Deep Underground Neutrino Experiment (DUNE) collaboration will perform an experiment centered on accelerator-based long-baseline neutrino studies along with nucleon decay and topics in neutrino astrophysics. It will consist of a modular 40-kt (fiducial) mass liquid argon TPC detector located deep underground at the Sanford Underground Research Facility in South Dakota and a high-resolution near detector at Fermilab in Illinois. This conguration provides a 1300-km baseline in a megawatt-scale neutrino beam provided by the Fermilab- hosted international Long-Baseline Neutrino Facility.

Tau Phosphorylation by GSK3 in Different Conditions

PubMed Central

Avila, Jesús; León-Espinosa, Gonzalo; García, Esther; García-Escudero, Vega; Hernández, Félix; DeFelipe, Javier

2012-01-01

Almost a 20% of the residues of tau protein are phosphorylatable amino acids: serine, threonine, and tyrosine. In this paper we comment on the consequences for tau of being a phosphoprotein. We will focus on serine/threonine phosphorylation. It will be discussed that, depending on the modified residue in tau molecule, phosphorylation could be protective, in processes like hibernation, or toxic like in development of those diseases known as tauopathies, which are characterized by an hyperphosphorylation and aggregation of tau. PMID:22675648

Active-sterile neutrino conversion: consequences for the r-process and supernova neutrino detection

NASA Astrophysics Data System (ADS)

Fetter, J.; McLaughlin, G. C.; Balantekin, A. B.; Fuller, G. M.

2003-02-01

We examine active-sterile neutrino conversion in the late time post-core-bounce supernova environment. By including the effect of feedback on the Mikheyev-Smirnov-Wolfenstein (MSW) conversion potential, we obtain a large range of neutrino mixing parameters which produce a favorable environment for the r-process. We look at the signature of this effect in the current generation of neutrino detectors now coming on line. We also investigate the impact of the neutrino-neutrino forward-scattering-induced potential on the MSW conversion.

Resolving neutrino mass hierarchy from supernova (anti)neutrino-nucleus reactions

NASA Astrophysics Data System (ADS)

Vale, Deni; Paar, Nils

2015-10-01

Recently a hybrid method has been introduced to determine neutrino mass hierarchy by simultaneous measurements of detector responses induced by antineutrino and neutrino fluxes from accretion and cooling phase of type II supernova. The (anti)neutrino-nucleus cross sections for 12C, 16O, 56Fe and 208Pb are calculated in the framework of relativistic nuclear energy density functional and weak interaction Hamiltonian, while the cross sections for inelastic scattering on free protons in mineral oil and water, p (v¯e,e+)n are obtained using heavy-baryon chiral perturbation theory. The simulations of (anti)neutrino fluxes emitted from a proto-neutron star in a core-collapse supernova include collective and Mikheyev-Smirnov-Wolfenstein effects inside star. It is shown that simultaneous use of ve/v¯e detectors with different target material allow to determine the neutrino mass hierarchy from the ratios of ve/v¯e induced particle emissions. The hybrid method favors detectors with heavier target nuclei (208Pb) for the neutrino sector, while for antineutrinos the use of free protons in mineral oil and water is more appropriate.

Supernovae neutrino pasta interaction

NASA Astrophysics Data System (ADS)

Lin, Zidu; Horowitz, Charles; Caplan, Matthew; Berry, Donald; Roberts, Luke

2017-01-01

In core-collapse supernovae, the neutron rich matter is believed to have complex structures, such as spherical, slablike, and rodlike shapes. They are collectively called ``nuclear pasta''. Supernovae neutrinos may scatter coherently on the ``nuclear pasta'' since the wavelength of the supernovae neutrinos are comparable to the nuclear pasta scale. Consequently, the neutrino pasta scattering is important to understand the neutrino opacity in the supernovae. In this work we simulated the ``nuclear pasta'' at different temperatures and densities using our semi-classical molecular dynamics and calculated the corresponding static structure factor that describes ν-pasta scattering. We found the neutrino opacities are greatly modified when the ``pasta'' exist and may have influence on the supernovae neutrino flux and average energy. Our neutrino-pasta scattering effect can finally be involved in the current supernovae simulations and we present preliminary proto neutron star cooling simulations including our pasta opacities.

Using Human iPSC-Derived Neurons to Model TAU Aggregation

PubMed Central

Verheyen, An; Diels, Annick; Dijkmans, Joyce; Oyelami, Tutu; Meneghello, Giulia; Mertens, Liesbeth; Versweyveld, Sofie; Borgers, Marianne; Buist, Arjan; Peeters, Pieter; Cik, Miroslav

2015-01-01

Alzheimer’s disease and frontotemporal dementia are amongst the most common forms of dementia characterized by the formation and deposition of abnormal TAU in the brain. In order to develop a translational human TAU aggregation model suitable for screening, we transduced TAU harboring the pro-aggregating P301L mutation into control hiPSC-derived neural progenitor cells followed by differentiation into cortical neurons. TAU aggregation and phosphorylation was quantified using AlphaLISA technology. Although no spontaneous aggregation was observed upon expressing TAU-P301L in neurons, seeding with preformed aggregates consisting of the TAU-microtubule binding repeat domain triggered robust TAU aggregation and hyperphosphorylation already after 2 weeks, without affecting general cell health. To validate our model, activity of two autophagy inducers was tested. Both rapamycin and trehalose significantly reduced TAU aggregation levels suggesting that iPSC-derived neurons allow for the generation of a biologically relevant human Tauopathy model, highly suitable to screen for compounds that modulate TAU aggregation. PMID:26720731

Effects of neutrino oscillations on nucleosynthesis and neutrino signals for an 18 M⊙ supernova model

NASA Astrophysics Data System (ADS)

Wu, Meng-Ru; Qian, Yong-Zhong; Martínez-Pinedo, Gabriel; Fischer, Tobias; Huther, Lutz

2015-03-01

In this paper, we explore the effects of neutrino flavor oscillations on supernova nucleosynthesis and on the neutrino signals. Our study is based on detailed information about the neutrino spectra and their time evolution from a spherically symmetric supernova model for an 18 M⊙ progenitor. We find that collective neutrino oscillations are not only sensitive to the detailed neutrino energy and angular distributions at emission, but also to the time evolution of both the neutrino spectra and the electron density profile. We apply the results of neutrino oscillations to study the impact on supernova nucleosynthesis and on the neutrino signals from a Galactic supernova. We show that in our supernova model, collective neutrino oscillations enhance the production of rare isotopes 138La and 180Ta but have little impact on the ν p -process nucleosynthesis. In addition, the adiabatic Mikheyev-Smirnov-Wolfenstein flavor transformation, which occurs in the C /O and He shells of the supernova, may affect the production of light nuclei such as 7Li and 11B. For the neutrino signals, we calculate the rate of neutrino events in the Super-Kamiokande detector and in a hypothetical liquid argon detector. Our results suggest the possibility of using the time profiles of the events in both detectors, along with the spectral information of the detected neutrinos, to infer the neutrino mass hierarchy.

Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies.

PubMed

Alonso, Alejandra del C; Li, Ben; Grundke-Iqbal, Inge; Iqbal, Khalid

2008-08-01

The accumulation of hyperphosphorylated tau is a common feature of several dementias. Tau is one of the brain microtubule-associated proteins. Here we discuss tau's function in microtubule assembly and stabilization and with regards to tau's interactions with other proteins, membranes, and DNA. We describe and analyze important posttranslational modifications: hyperphosphorylation, glycosylation, ubiquitination, glycation, polyamination, nitration, and truncation. We discuss how these post-translational modifications can alter tau's biological function and what is known about tau self-assembly, and we propose a mechanism of tau polymerization. We analyze the impact of natural mutations on tau that cause fronto-temporal dementia associated with chromosome 17 (FTDP-1 7). Finally, we consider whether tau accumulation or its conformational change is related to tau-induced neurodegeneration, and we propose a mechanism of neurodegeneration.

Search for sterile neutrinos in muon neutrino disappearance mode at FNAL

NASA Astrophysics Data System (ADS)

Anokhina, A.; Bagulya, A.; Benettoni, M.; Bernardini, P.; Brugnera, R.; Calabrese, M.; Cecchetti, A.; Cecchini, S.; Chernyavskiy, M.; Dal Corso, F.; Dalkarov, O.; Del Prete, A.; De Robertis, G.; De Serio, M.; Di Ferdinando, D.; Dusini, S.; Dzhatdoev, T.; Fini, R. A.; Fiore, G.; Garfagnini, A.; Guerzoni, M.; Klicek, B.; Kose, U.; Jakovcic, K.; Laurenti, G.; Lippi, I.; Loddo, F.; Longhin, A.; Malenica, M.; Mancarella, G.; Mandrioli, G.; Margiotta, A.; Marsella, G.; Mauri, N.; Medinaceli, E.; Mingazheva, R.; Morgunova, O.; Muciaccia, M. T.; Nessi, M.; Orecchini, D.; Paoloni, A.; Papadia, G.; Paparella, L.; Pasqualini, L.; Pastore, A.; Patrizii, L.; Polukhina, N.; Pozzato, M.; Roda, M.; Roganova, T.; Rosa, G.; Sahnoun, Z.; Shchedrina, T.; Simone, S.; Sirignano, C.; Sirri, G.; Spurio, M.; Stanco, L.; Starkov, N.; Stipcevic, M.; Surdo, A.; Tenti, M.; Togo, V.; Vladymyrov, M.

2017-01-01

The NESSiE Collaboration has been setup to undertake a conclusive experiment to clarify the muon-neutrino disappearance measurements at short baselines in order to put severe constraints to models with more than the three-standard neutrinos. To this aim the current FNAL-Booster neutrino beam for a Short-Baseline experiment was carefully evaluated by considering the use of magnetic spectrometers at two sites, near and far ones. The detector locations were studied, together with the achievable performances of two OPERA-like spectrometers. The study was constrained by the availability of existing hardware and a time-schedule compatible with the undergoing project of multi-site Liquid-Argon detectors at FNAL. The settled physics case and the kind of proposed experiment on the Booster neutrino beam would definitively clarify the existing tension between the ν _{μ } disappearance and the ν e appearance/disappearance at the eV mass scale. In the context of neutrino oscillations the measurement of ν _{μ } disappearance is a robust and fast approach to either reject or discover new neutrino states at the eV mass scale. We discuss an experimental program able to extend by more than one order of magnitude (for neutrino disappearance) and by almost one order of magnitude (for antineutrino disappearance) the present range of sensitivity for the mixing angle between standard and sterile neutrinos. These extensions are larger than those achieved in any other proposal presented so far.

Neutrino-Driven Explosions

NASA Astrophysics Data System (ADS)

Janka, Hans-Thomas

The question why and how core-collapse supernovae (SNe) explode is one of the central and most long-standing riddles of stellar astrophysics. Solving this problem is crucial for deciphering the supernova (SN) phenomenon; for predicting its observable signals such as light curves and spectra, nucleosynthesis yields, neutrinos, and gravitational waves; for defining the role of SNe in the dynamical and chemo-dynamical evolution of galaxies; and for explaining the birth conditions and properties of neutron stars (NSs) and stellar-mass black holes. Since the formation of such compact remnants releases over hundred times more energy in neutrinos than the kinetic energy of the SN explosion, neutrinos can be the decisive agents for powering the SN outburst. According to the standard paradigm of the neutrino-driven mechanism, the energy transfer by the intense neutrino flux to the medium behind the stagnating core bounce shock, assisted by violent hydrodynamic mass motions (sometimes subsumed by the term "turbulence"), revives the outward shock motion and thus initiates the SN explosion. Because of the weak coupling of neutrinos in the region of this energy deposition, detailed, multidimensional hydrodynamic models including neutrino transport and a wide variety of physics are needed to assess the viability of the mechanism. Owing to advanced numerical codes and increasing supercomputer power, considerable progress has been achieved in our understanding of the physical processes that have to act in concert for the success of neutrino-driven explosions. First studies begin to reveal observational implications and avenues to test the theoretical picture by data from individual SNe and SN remnants but also from population-integrated observables. While models will be further refined, a real breakthrough is expected through the next galactic core-collapse SN, when neutrinos and gravitational waves can be used to probe the conditions deep inside the dying star.

Dark matter, baryogenesis and neutrino oscillations from right-handed neutrinos

NASA Astrophysics Data System (ADS)

Canetti, Laurent; Drewes, Marco; Frossard, Tibor; Shaposhnikov, Mikhail

2013-05-01

We show that, leaving aside accelerated cosmic expansion, all experimental data in high energy physics that are commonly agreed to require physics beyond the Standard Model can be explained when completing the model by three right-handed neutrinos that can be searched for using present-day experimental techniques. The model that realizes this scenario is known as the Neutrino Minimal Standard Model (νMSM). In this article we give a comprehensive summary of all known constraints in the νMSM, along with a pedagogical introduction to the model. We present the first complete quantitative study of the parameter space of the model where no physics beyond the νMSM is needed to simultaneously explain neutrino oscillations, dark matter, and the baryon asymmetry of the Universe. The key new point of our analysis is leptogenesis after sphaleron freeze-out, which leads to resonant dark matter production, thus evading the constraints on sterile neutrino dark matter from structure formation and x-ray searches. This requires one to track the time evolution of left- and right-handed neutrino abundances from hot big bang initial conditions down to temperatures below the QCD scale. We find that the interplay of resonant amplifications, CP-violating flavor oscillations, scatterings, and decays leads to a number of previously unknown constraints on the sterile neutrino properties. We furthermore reanalyze bounds from past collider experiments and big bang nucleosynthesis in the face of recent evidence for a nonzero neutrino mixing angle θ13. We combine all our results with existing constraints on dark matter properties from astrophysics and cosmology. Our results provide a guideline for future experimental searches for sterile neutrinos. A summary of the constraints on sterile neutrino masses and mixings has appeared in Canetti et al. [Phys. Rev. Lett. 110, 061801 (2013)PRLTAO0031-9007]. In this article we provide all details of our calculations and give constraints on other model

Sterile neutrinos or flux uncertainties? — Status of the reactor anti-neutrino anomaly

NASA Astrophysics Data System (ADS)

Dentler, Mona; Hernández-Cabezudo, Álvaro; Kopp, Joachim; Maltoni, Michele; Schwetz, Thomas

2017-11-01

The ˜ 3 σ discrepancy between the predicted and observed reactor anti-neutrino flux, known as the reactor anti-neutrino anomaly, continues to intrigue. The recent discovery of an unexpected bump in the reactor anti-neutrino spectrum, as well as indications that the flux deficit is different for different fission isotopes seems to disfavour the explanation of the anomaly in terms of sterile neutrino oscillations. We critically review this conclusion in view of all available data on electron (anti)neutrino disappearance. We find that the sterile neutrino hypothesis cannot be rejected based on global data and is only mildly disfavored compared to an individual rescaling of neutrino fluxes from different fission isotopes. The main reason for this is the presence of spectral features in recent data from the NEOS and DANSS experiments. If state-of-the-art predictions for reactor fluxes are taken at face value, sterile neutrino oscillations allow a consistent description of global data with a significance close to 3 σ relative to the no-oscillation case. Even if reactor fluxes and spectra are left free in the fit, a 2 σ hint in favour of sterile neutrinos remains, with allowed parameter regions consistent with an explanation of the anomaly in terms of oscillations.

Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

PubMed Central

Hoover, Brian R.; Reed, Miranda N.; Su, Jianjun; Penrod, Rachel D.; Kotilinek, Linda A.; Grant, Marianne K.; Pitstick, Rose; Carlson, George A.; Lanier, Lorene M.; Yuan, Li-Lian; Ashe, Karen H.; Liao, Dezhi

2010-01-01

The microtubule-associated protein tau accumulates in Alzheimer’s and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related deficits develop not from the loss of synapses or neurons, but rather as a result of synaptic abnormalities caused by the accumulation of hyperphosphorylated tau within intact dendritic spines, where it disrupts synaptic function by impairing glutamate receptor trafficking or synaptic anchoring. Mutagenesis of 14 disease-associated serine and threonine amino acid residues to create pseudohyperphosphorylated tau caused tau mislocalization while creation of phosphorylation-deficient tau blocked the mis-targeting of tau to dendritic spines. Thus, tau phosphorylation plays a critical role in mediating tau mislocalization and subsequent synaptic impairment. These data establish that the locus of early synaptic malfunction caused by tau resides in dendritic spines. PMID:21172610

Solar neutrinos as a probe of dark matter-neutrino interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Capozzi, Francesco; Vecchi, Luca; Shoemaker, Ian M., E-mail: capozzi.12@osu.edu, E-mail: ian.shoemaker@usd.edu, E-mail: vecchi@infn.pd.it

2017-07-01

Sterile neutrinos at the eV scale have long been studied in the context of anomalies in short baseline neutrino experiments. Their cosmology can be made compatible with our understanding of the early Universe provided the sterile neutrino sector enjoys a nontrivial dynamics with exotic interactions, possibly providing a link to the Dark Matter (DM) puzzle. Interactions between DM and neutrinos have also been proposed to address the long-standing 'missing satellites' problem in the field of large scale structure formation. Motivated by these considerations, in this paper we discuss realistic scenarios with light steriles coupled to DM . We point outmore » that within this framework active neutrinos acquire an effective coupling to DM that manifests itself as a new matter potential in the propagation within a medium of asymmetric DM . Assuming that at least a small fraction of asymmetric DM has been captured by the Sun, we show that a sizable region of the parameter space of these scenarios can be probed by solar neutrino experiments, especially in the regime of small couplings and light mediators where all other probes become inefficient. In the latter regime these scenarios behave as familiar 3+1 models in all channels except for solar data, where a Solar Dark MSW effect takes place. Solar Dark MSW is characterized by modifications of the most energetic {sup 8}B and CNO neutrinos, whereas the other fluxes remain largely unaffected.« less

Solar neutrinos as a probe of dark matter-neutrino interactions

NASA Astrophysics Data System (ADS)

Capozzi, Francesco; Shoemaker, Ian M.; Vecchi, Luca

2017-07-01

Sterile neutrinos at the eV scale have long been studied in the context of anomalies in short baseline neutrino experiments. Their cosmology can be made compatible with our understanding of the early Universe provided the sterile neutrino sector enjoys a nontrivial dynamics with exotic interactions, possibly providing a link to the Dark Matter (DM) puzzle. Interactions between DM and neutrinos have also been proposed to address the long-standing "missing satellites" problem in the field of large scale structure formation. Motivated by these considerations, in this paper we discuss realistic scenarios with light steriles coupled to DM . We point out that within this framework active neutrinos acquire an effective coupling to DM that manifests itself as a new matter potential in the propagation within a medium of asymmetric DM . Assuming that at least a small fraction of asymmetric DM has been captured by the Sun, we show that a sizable region of the parameter space of these scenarios can be probed by solar neutrino experiments, especially in the regime of small couplings and light mediators where all other probes become inefficient. In the latter regime these scenarios behave as familiar 3+1 models in all channels except for solar data, where a Solar Dark MSW effect takes place. Solar Dark MSW is characterized by modifications of the most energetic 8B and CNO neutrinos, whereas the other fluxes remain largely unaffected.

Salt Neutrino Detector for Ultrahigh-Energy Neutrinos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chiba, M.; Yasuda, O.; Kamijo, T.

2004-11-01

Rock salt and limestone are studied to determine their suitability for use as a radio-wave transmission medium in an ultrahigh energy (UHE) cosmic neutrino detector. A sensible radio wave would be emitted by the coherent Cherenkov radiation from negative excess charges inside an electromagnetic shower upon interaction of a UHE neutrino in a high-density medium (Askar'yan effect). If the attenuation length for the radio wave in the material is large, a relatively small number of radio-wave sensors could detect the interaction occurring in the massive material. We measured the complex permittivity of the rock salt and limestone by the perturbedmore » cavity resonator method at 9.4 and 1 GHz to good precision. We obtained new results of measurements at the frequency at 1.0 GHz. The measured value of the radio-wave attenuation length of synthetic rock salt samples is 1080 m. The samples from the Hockley salt mine in the United States show attenuation length of 180 m at 1 GHz, and then we estimate it by extrapolation to be as long as 900 m at 200 MHz. The results show that there is a possibility of utilizing natural massive deposits of rock salt for a UHE neutrino detector. A salt neutrino detector with a size of 2 x 2 x 2 km would detect 10 UHE neutrino/yr generated through the GZK process.« less

Dimer model for Tau proteins bound in microtubule bundles

NASA Astrophysics Data System (ADS)

Hall, Natalie; Kluber, Alexander; Hayre, N. Robert; Singh, Rajiv; Cox, Daniel

2013-03-01

The microtubule associated protein tau is important in nucleating and maintaining microtubule spacing and structure in neuronal axons. Modification of tau is implicated as a later stage process in Alzheimer's disease, but little is known about the structure of tau in microtubule bundles. We present preliminary work on a proposed model for tau dimers in microtubule bundles (dimers are the minimal units since there is one microtubule binding domain per tau). First, a model of tau monomer was created and its characteristics explored using implicit solvent molecular dynamics simulation. Multiple simulations yield a partially collapsed form with separate positively/negatively charged clumps, but which are a factor of two smaller than required by observed microtubule spacing. We argue that this will elongate in dimer form to lower electrostatic energy at a cost of entropic ``spring'' energy. We will present preliminary results on steered molecular dynamics runs on tau dimers to estimate the actual force constant. Supported by US NSF Grant DMR 1207624.

Recent Developments in Neutrino Science: A Whole Lot About Almost Nothing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Norman, E B

2005-08-22

Results from Super-K, SNO, and KamLAND provide strong evidence that neutrinos undergo flavor-changing oscillations and therefore have non-zero mass. The {nu}-disappearance observations by KamLAND, assuming CPT conservation, point to matter enhanced (MSW) oscillations with large mixing angles as the solution to the solar neutrino problem--a result consistent with the MSW parameters recently defined by these experiments. This requires that the observed neutrino flavors (e, {mu}, and tau) are not mass eigenstates, but are linear combinations of the mass eigenstates of the neutrino. However, such oscillation experiments can only determine the differences in the masses of the neutrinos, not the absolutemore » scale of neutrino mass. What can be inferred from these experiments is that at least one species of neutrino has a mass greater than 55 meV. In fact, the WMAP observations of large-scale structure point to a sum-neutrino mass of {approx} 0.7 eV (roughly 0.25 eV/species assuming democracy between the flavors). Furthermore, there is still the important issue of whether the neutrino and anti-neutrino are distinct particles (i.e. Dirac type) or not (Majorana type). The only way to answer both of these questions is through neutrinoless double beta decay (DBD) experiments. CUORE (Cryogenic Underground Observatory for Rare Events) is a proposed next generation experiment designed to search for the neutrinoless DBD of {sup 130}Te using a bolometric technique. The source/detector will be composed of 988 5 x 5 x 5-cm single crystals of TeO{sub 2} all housed in a common dilution refrigerator and operated at a temperature of 8-10 mK. The total mass of {sup 130}Te contained in CUORE will be approximately 203 kg. Attached to each crystal will be one or more neutron-transmutation doped (NTD) germanium thermistors that will measure the small temperature rise produced in a crystal when radiation is absorbed. A schematic illustration of the CUORE detector is shown in Figure 1

Search for neutral minimal supersymmetric standard model Higgs bosons decaying to tau pairs produced in association with b quarks in pp collisions at √s = 1.96 TeV.

PubMed

Abazov, V M; Abbott, B; Acharya, B S; Adams, M; Adams, T; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Aoki, M; Arov, M; Askew, A; Åsman, B; Atramentov, O; Avila, C; BackusMayes, J; Badaud, F; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, S; Barberis, E; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bazterra, V; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Blazey, G; Blessing, S; Bloom, K; Boehnlein, A; Boline, D; Boos, E E; Borissov, G; Bose, T; Brandt, A; Brandt, O; Brock, R; Brooijmans, G; Bross, A; Brown, D; Brown, J; Bu, X B; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Burnett, T H; Buszello, C P; Calpas, B; Camacho-Pérez, E; Carrasco-Lizarraga, M A; Casey, B C K; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K M; Chandra, A; Chen, G; Chevalier-Théry, S; Cho, D K; Cho, S W; Choi, S; Choudhary, B; Cihangir, S; Claes, D; Clutter, J; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Croc, A; Cutts, D; Das, A; Davies, G; De, K; de Jong, S J; De La Cruz-Burelo, E; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Deterre, C; DeVaughan, K; Diehl, H T; Diesburg, M; Ding, P F; Dominguez, A; Dorland, T; Dubey, A; Dudko, L V; Duggan, D; Duperrin, A; Dutt, S; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Evans, H; Evdokimov, A; Evdokimov, V N; Facini, G; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Fuess, S; Garcia-Bellido, A; Gavrilov, V; Gay, P; Geng, W; Gerbaudo, D; Gerber, C E; Gershtein, Y; Ginther, G; Golovanov, G; Goussiou, A; Grannis, P D; Greder, S; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guillemin, T; Guo, F; Gutierrez, G; Gutierrez, P; Haas, A; Hagopian, S; Haley, J; Han, L; Harder, K; Harel, A; Hauptman, J M; Hays, J; Head, T; Hebbeker, T; Hedin, D; Hegab, H; Heinson, A P; Heintz, U; Hensel, C; Heredia-De La Cruz, I; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hoang, T; Hobbs, J D; Hoeneisen, B; Hohlfeld, M; Hubacek, Z; Huske, N; Hynek, V; Iashvili, I; Ilchenko, Y; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jamin, D; Jayasinghe, A; Jesik, R; Johns, K; Johnson, M; Johnston, D; Jonckheere, A; Jonsson, P; Joshi, J; Jung, A W; Juste, A; Kaadze, K; Kajfasz, E; Karmanov, D; Kasper, P A; Katsanos, I; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y N; Kirby, M H; Kohli, J M; Kozelov, A V; Kraus, J; Kulikov, S; Kumar, A; Kupco, A; Kurča, T; Kuzmin, V A; Kvita, J; Lammers, S; Landsberg, G; Lebrun, P; Lee, H S; Lee, S W; Lee, W M; Lellouch, J; Li, L; Li, Q Z; Lietti, S M; Lim, J K; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobodenko, A; Lokajicek, M; Lopes de Sa, R; Lubatti, H J; Luna-Garcia, R; Lyon, A L; Maciel, A K A; Mackin, D; Madar, R; Magaña-Villalba, R; Malik, S; Malyshev, V L; Maravin, Y; Martínez-Ortega, J; McCarthy, R; McGivern, C L; Meijer, M M; Melnitchouk, A; Menezes, D; Mercadante, P G; Merkin, M; Meyer, A; Meyer, J; Miconi, F; Mondal, N K; Muanza, G S; Mulhearn, M; Nagy, E; Naimuddin, M; Narain, M; Nayyar, R; Neal, H A; Negret, J P; Neustroev, P; Novaes, S F; Nunnemann, T; Obrant, G; Orduna, J; Osman, N; Osta, J; Otero y Garzón, G J; Padilla, M; Pal, A; Parashar, N; Parihar, V; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Penning, B; Perfilov, M; Peters, K; Peters, Y; Petridis, K; Petrillo, G; Pétroff, P; Piegaia, R; Pleier, M-A; Podesta-Lerma, P L M; Podstavkov, V M; Polozov, P; Popov, A V; Prewitt, M; Price, D; Prokopenko, N; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rangel, M S; Ranjan, K; Ratoff, P N; Razumov, I; Renkel, P; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Rominsky, M; Ross, A; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Salcido, P; Sánchez-Hernández, A; Sanders, M P; Sanghi, B; Santos, A S; Savage, G; Sawyer, L; Scanlon, T; Schamberger, R D; Scheglov, Y; Schellman, H; Schliephake, T; Schlobohm, S; Schwanenberger, C; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shary, V; Shchukin, A A; Shivpuri, R K; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Smith, K J; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Soustruznik, K; Stark, J; Stolin, V; Stoyanova, D A; Strauss, M; Strom, D; Stutte, L; Suter, L; Svoisky, P; Takahashi, M; Tanasijczuk, A; Taylor, W; Titov, M; Tokmenin, V V; Tsai, Y-T; Tschann-Grimm, K; Tsybychev, D; Tuchming, B; Tully, C; Uvarov, L; Uvarov, S; Uzunyan, S; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Verdier, P; Vertogradov, L S; Verzocchi, M; Vesterinen, M; Vilanova, D; Vokac, P; Wahl, H D; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, M; Welty-Rieger, L; White, A; Wicke, D; Williams, M R J; Wilson, G W; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Xu, C; Yacoob, S; Yamada, R; Yang, W-C; Yasuda, T; Yatsunenko, Y A; Ye, Z; Yin, H; Yip, K; Youn, S W; Yu, J; Zelitch, S; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zivkovic, L

2011-09-16

We report results from a search for neutral Higgs bosons produced in association with b quarks using data recorded by the D0 experiment at the Fermilab Tevatron Collider and corresponding to an integrated luminosity of 7.3 fb(-1). This production mode can be enhanced in several extensions of the standard model (SM) such as in its minimal supersymmetric extension (MSSM) at high tanβ. We search for Higgs bosons decaying to tau pairs with one tau decaying to a muon and neutrinos and the other to hadrons. The data are found to be consistent with SM expectations, and we set upper limits on the cross section times branching ratio in the Higgs boson mass range from 90 to 320 GeV/c(2). We interpret our result in the MSSM parameter space, excluding tanβ values down to 25 for Higgs boson masses below 170 GeV/c(2).

Status of the OPERA experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russo, A.

2011-11-23

The OPERA experiment in the underground Gran Sasso Laboratory (LNGS) has been designed to perform the first detection of neutrino oscillations in direct appearance mode in the muon to tau neutrino channel. The detector is hybrid, being made of an emulsion/lead target and of electronic detectors. It is placed in the CNGS neutrino beam 733 km away from the neutrino source. Runs with CNGS neutrinos were successfully carried out from 2008 and the following years. The analysis of a sample of events corresponding to 1.89x10{sup 19} p.o.t. in the CERN CNGS {nu}{sub {mu}} beam yielded the observation of a firstmore » candidate {nu}{sub {tau}} CC interaction. The topology and kinematics of this candidate event is described in detail. The background sources are explained and the significance of the observation of the first {nu}{sub {tau}} event candidate is assessed.« less

Measurement of Neutrino Oscillation Parameters from Muon Neutrino Disappearance with an Off-Axis Beam

NASA Astrophysics Data System (ADS)

Abe, K.; Adam, J.; Aihara, H.; Akiri, T.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Ariga, T.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bass, M.; Batkiewicz, M.; Bay, F.; Bentham, S. W.; Berardi, V.; Berger, B. E.; Berkman, S.; Bertram, I.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Curioni, A.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S. R.; Densham, C.; Di Lodovico, F.; Di Luise, S.; Drapier, O.; Duboyski, T.; Duffy, K.; Dufour, F.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Emery, S.; Ereditato, A.; Escudero, L.; Finch, A. J.; Frank, E.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Gaudin, A.; Giffin, S.; Giganti, C.; Gilje, K.; Golan, T.; Gomez-Cadenas, J. J.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Ives, S. J.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Johnson, R. A.; Jo, J. H.; Jonsson, P.; Joo, K. K.; Jung, C. K.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J.; Kim, S. B.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Kogan, G.; Kolaceke, A.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kreslo, I.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kumaratunga, S.; Kurjata, R.; Kutter, T.; Lagoda, J.; Laihem, K.; Laveder, M.; Lawe, M.; Lazos, M.; Lee, K. P.; Licciardi, C.; Lim, I. T.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Lopez, G. D.; Ludovici, L.; Macaire, M.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marino, A. D.; Marteau, J.; Martin, J. F.; Maruyama, T.; Marzec, J.; Masliah, P.; Mathie, E. L.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Metelko, C.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Mine, S.; Missert, A.; Miura, M.; Monfregola, L.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nagasaki, T.; Nakadaira, T.; Nakahata, M.; Nakai, T.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Naples, D.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Otani, M.; Owen, R. A.; Oyama, Y.; Pac, M. Y.; Palladino, V.; Paolone, V.; Payne, D.; Pearce, G. F.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pinzon Guerra, E. S.; Pistillo, C.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Redij, A.; Reeves, M.; Reinherz-Aronis, E.; Retiere, F.; Robert, A.; Rodrigues, P. A.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smith, R. J.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suda, Y.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Szeglowski, T.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. K.; Tanaka, H. A.; Tanaka, M. M.; Taylor, I. J.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Ueno, K.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yen, S.; Yershov, N.; Yokoyama, M.; Yuan, T.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.

2013-11-01

The T2K Collaboration reports a precision measurement of muon neutrino disappearance with an off-axis neutrino beam with a peak energy of 0.6 GeV. Near detector measurements are used to constrain the neutrino flux and cross section parameters. The Super-Kamiokande far detector, which is 295 km downstream of the neutrino production target, collected data corresponding to 3.01×1020 protons on target. In the absence of neutrino oscillations, 205±17 (syst) events are expected to be detected while only 58 muon neutrino event candidates are observed. A fit to the neutrino rate and energy spectrum, assuming three neutrino flavors and normal mass hierarchy yields a best-fit mixing angle sin⁡2(θ23)=0.514±0.082 and mass splitting |Δm322|=2.44-0.15+0.17×10-3eV2/c4. Our result corresponds to the maximal oscillation disappearance probability.

Neutrino conversion in a neutrino flux: towards an effective theory of collective oscillations

NASA Astrophysics Data System (ADS)

Hansen, Rasmus S. L.; Smirnov, Alexei Yu.

2018-04-01

Collective oscillations of supernova neutrinos above the neutrino sphere can be completely described by the propagation of individual neutrinos in external potentials and are in this sense a linear phenomenon. An effective theory of collective oscillations can be developed based on certain assumptions about time dependence of these potentials. General conditions for strong flavor transformations are formulated and these transformations can be interpreted as parametric resonance effects induced by periodic modulations of the potentials. We study a simplified and solvable example, where a probe neutrino is propagating in a flux of collinear neutrinos, such that ν ν‑ interactions in the flux are absent. Still, this example retains the main feature—the coherent flavor exchange. Properties of the parametric resonance are studied, and it is shown that integrations over energies and emission points of the flux neutrinos suppress modulations of the potentials and therefore strong transformations. The transformations are also suppressed by changes in densities of background neutrinos and electrons.

Tyrosine Nitration within the Proline-Rich Region of Tau in Alzheimer's Disease

PubMed Central

Reyes, Juan F.; Fu, Yifan; Vana, Laurel; Kanaan, Nicholas M.; Binder, Lester I.

2011-01-01

A substantial body of evidence suggests that nitrative injury contributes to neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative disorders. Previously, we showed in vitro that within the tau protein the N-terminal tyrosine residues (Y18 and Y29) are more susceptible to nitrative modifications than other tyrosine sites (Y197 and Y394). Using site-specific antibodies to nitrated tau at Y18 and Y29, we identified tau nitrated in both glial (Y18) and neuronal (Y29) tau pathologies. In this study, we report the characterization of two novel monoclonal antibodies, Tau-nY197 and Tau-nY394, recognizing tau nitrated at Y197 and Y394, respectively. By Western blot analysis, Tau-nY197 labeled soluble tau and insoluble paired helical filament proteins (PHF-tau) nitrated at Y197 from control and AD brain samples. Tau-nY394 failed to label soluble tau isolated from control or severe AD samples, but labeled insoluble PHF-tau to a limited extent. Immunohistochemical analysis using Tau-nY197 revealed the hallmark tau pathology associated with AD; Tau-nY394 did not detect any pathological lesions characteristic of the disorder. These data suggest that a subset of the hallmark pathological inclusions of AD contain tau nitrated at Y197. However, nitration at Y197 was also identified in soluble tau from all control samples, including those at Braak stage 0, suggesting that nitration at this site in the proline-rich region of tau may have normal biological functions in the human brain. PMID:21514440

Complete mitochondrial genome of Zeugodacus tau (Insecta: Tephritidae) and differentiation of Z. tau species complex by mitochondrial cytochrome c oxidase subunit I gene

PubMed Central

Yong, Hoi-Sen; Lim, Phaik-Eem; Eamsobhana, Praphathip

2017-01-01

The tephritid fruit fly Zeugodacus tau (Walker) is a polyphagous fruit pest of economic importance in Asia. Studies based on genetic markers indicate that it forms a species complex. We report here (1) the complete mitogenome of Z. tau from Malaysia and comparison with that of China as well as the mitogenome of other congeners, and (2) the relationship of Z. tau taxa from different geographical regions based on sequences of cytochrome c oxidase subunit I gene. The complete mitogenome of Z. tau had a total length of 15631 bp for the Malaysian specimen (ZT3) and 15835 bp for the China specimen (ZT1), with similar gene order comprising 37 genes (13 protein-coding genes—PCGs, 2 rRNA genes, and 22 tRNA genes) and a non-coding A + T-rich control region (D-loop). Based on 13 PCGs and 15 mt-genes, Z. tau NC_027290 (China) and Z. tau ZT1 (China) formed a sister group in the lineage containing also Z. tau ZT3 (Malaysia). Phylogenetic analysis based on partial sequences of cox1 gene indicates that the taxa from China, Japan, Laos, Malaysia, Bangladesh, India, Sri Lanka, and Z. tau sp. A from Thailand belong to Z. tau sensu stricto. A complete cox1 gene (or 13 PCGs or 15 mt-genes) instead of partial sequence is more appropriate for determining phylogenetic relationship. PMID:29216281

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

PubMed

Kovacs, Gabor G; Ferrer, Isidro; Grinberg, Lea T; Alafuzoff, Irina; Attems, Johannes; Budka, Herbert; Cairns, Nigel J; Crary, John F; Duyckaerts, Charles; Ghetti, Bernardino; Halliday, Glenda M; Ironside, James W; Love, Seth; Mackenzie, Ian R; Munoz, David G; Murray, Melissa E; Nelson, Peter T; Takahashi, Hitoshi; Trojanowski, John Q; Ansorge, Olaf; Arzberger, Thomas; Baborie, Atik; Beach, Thomas G; Bieniek, Kevin F; Bigio, Eileen H; Bodi, Istvan; Dugger, Brittany N; Feany, Mel; Gelpi, Ellen; Gentleman, Stephen M; Giaccone, Giorgio; Hatanpaa, Kimmo J; Heale, Richard; Hof, Patrick R; Hofer, Monika; Hortobágyi, Tibor; Jellinger, Kurt; Jicha, Gregory A; Ince, Paul; Kofler, Julia; Kövari, Enikö; Kril, Jillian J; Mann, David M; Matej, Radoslav; McKee, Ann C; McLean, Catriona; Milenkovic, Ivan; Montine, Thomas J; Murayama, Shigeo; Lee, Edward B; Rahimi, Jasmin; Rodriguez, Roberta D; Rozemüller, Annemieke; Schneider, Julie A; Schultz, Christian; Seeley, William; Seilhean, Danielle; Smith, Colin; Tagliavini, Fabrizio; Takao, Masaki; Thal, Dietmar Rudolf; Toledo, Jon B; Tolnay, Markus; Troncoso, Juan C; Vinters, Harry V; Weis, Serge; Wharton, Stephen B; White, Charles L; Wisniewski, Thomas; Woulfe, John M; Yamada, Masahito; Dickson, Dennis W

2016-01-01

Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

PubMed Central

Ferrer, Isidro; Grinberg, Lea T.; Alafuzoff, Irina; Attems, Johannes; Budka, Herbert; Cairns, Nigel J.; Crary, John F.; Duyckaerts, Charles; Ghetti, Bernardino; Halliday, Glenda M.; Ironside, James W.; Love, Seth; Mackenzie, Ian R.; Munoz, David G.; Murray, Melissa E.; Nelson, Peter T.; Takahashi, Hitoshi; Trojanowski, John Q.; Ansorge, Olaf; Arzberger, Thomas; Baborie, Atik; Beach, Thomas G.; Bieniek, Kevin F.; Bigio, Eileen H.; Bodi, Istvan; Dugger, Brittany N.; Feany, Mel; Gelpi, Ellen; Gentleman, Stephen M.; Giaccone, Giorgio; Hatanpaa, Kimmo J.; Heale, Richard; Hof, Patrick R.; Hofer, Monika; Hortobágyi, Tibor; Jellinger, Kurt; Jicha, Gregory A.; Ince, Paul; Kofler, Julia; Kövari, Enikö; Kril, Jillian J.; Mann, David M.; Matej, Radoslav; McKee, Ann C.; McLean, Catriona; Milenkovic, Ivan; Montine, Thomas J.; Murayama, Shigeo; Lee, Edward B.; Rahimi, Jasmin; Rodriguez, Roberta D.; Rozemüller, Annemieke; Schneider, Julie A.; Schultz, Christian; Seeley, William; Seilhean, Danielle; Smith, Colin; Tagliavini, Fabrizio; Takao, Masaki; Thal, Dietmar Rudolf; Toledo, Jon B.; Tolnay, Markus; Troncoso, Juan C.; Vinters, Harry V.; Weis, Serge; Wharton, Stephen B.; White, Charles L.; Wisniewski, Thomas; Woulfe, John M.; Yamada, Masahito

2016-01-01

Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of

Neutrino Astronomy with IceCube

NASA Astrophysics Data System (ADS)

Meagher, Kevin J.

The IceCube Neutrino Observatory is a cubic kilometer neutrino telescope located at the Geographic South Pole. Cherenkov radiation emitted by charged secondary particles from neutrino interactions is observed by IceCube using an array of 5160 photomultiplier tubes embedded between a depth of 1.5 km to 2.5 km in the Antarctic glacial ice. The detection of astrophysical neutrinos is a primary goal of IceCube and has now been realized with the discovery of a diffuse, high-energy flux consisting of neutrino events from tens of TeV up to several PeV. Many analyses have been performed to identify the source of these neutrinos: correlations with active galactic nuclei, gamma-ray bursts, and the galactic plane. IceCube also conducts multi-messenger campaigns to alert other observatories of possible neutrino transients in real-time. However, the source of these neutrinos remains elusive as no corresponding electromagnetic counterparts have been identified. This proceeding will give an overview of the detection principles of IceCube, the properties of the observed astrophysical neutrinos, the search for corresponding sources (including real-time searches), and plans for a next-generation neutrino detector, IceCube-Gen2.

Simulation of coherent nonlinear neutrino flavor transformation in the supernova environment: Correlated neutrino trajectories

NASA Astrophysics Data System (ADS)

Duan, Huaiyu; Fuller, George M.; Carlson, J.; Qian, Yong-Zhong

2006-11-01

We present results of large-scale numerical simulations of the evolution of neutrino and antineutrino flavors in the region above the late-time post-supernova-explosion proto-neutron star. Our calculations are the first to allow explicit flavor evolution histories on different neutrino trajectories and to self-consistently couple flavor development on these trajectories through forward scattering-induced quantum coupling. Employing the atmospheric-scale neutrino mass-squared difference (|δm2|≃3×10-3eV2) and values of θ13 allowed by current bounds, we find transformation of neutrino and antineutrino flavors over broad ranges of energy and luminosity in roughly the “bi-polar” collective mode. We find that this large-scale flavor conversion, largely driven by the flavor off-diagonal neutrino-neutrino forward scattering potential, sets in much closer to the proto-neutron star than simple estimates based on flavor-diagonal potentials and Mikheyev-Smirnov-Wolfenstein evolution would indicate. In turn, this suggests that models of r-process nucleosynthesis sited in the neutrino-driven wind could be affected substantially by active-active neutrino flavor mixing, even with the small measured neutrino mass-squared differences.

TBI-Induced Formation of Toxic Tau and Its Biochemical Similarities to Tau in AD Brains

DTIC Science & Technology

2016-10-01

onto wild-type mice markedly reduces 1) memory including contextual fear memory and spatial memory, and 2) long-term potentiation, a type of...TERMS Tau, contextual fear memory, spatial memory, synaptic plasticity, traumatic brain injury, Alzheimer’s disease 16. SECURITY CLASSIFICATION OF: 17...mechanism leading to TBI and AD. 2 KEYWORDS Tau, contextual fear memory, spatial memory, synaptic plasticity, traumatic brain injury, Alzheimer’s

An Experimentalist's Overview of Solar Neutrinos

NASA Astrophysics Data System (ADS)

Oser, Scott M.

2012-02-01

Four decades of solar neutrino research have demonstrated that solar models do a remarkable job of predicting the neutrino fluxes from the Sun, to the extent that solar neutrinos can now serve as a calibrated neutrino source for experiments to understand neutrino oscillations and mixing. In this review article I will highlight the most significant experimental results, with emphasis on the latest model-independent measurements from the Sudbury Neutrino Observatory. The solar neutrino fluxes are seen to be generally well-determined experimentally, with no indications of time variability, while future experiments will elucidate the lower energy part of the neutrino spectrum, especially pep and CNO neutrinos.

Probing light sterile neutrino signatures at reactor and Spallation Neutron Source neutrino experiments

NASA Astrophysics Data System (ADS)

Kosmas, T. S.; Papoulias, D. K.; Tórtola, M.; Valle, J. W. F.

2017-09-01

We investigate the impact of a fourth sterile neutrino at reactor and Spallation Neutron Source neutrino detectors. Specifically, we explore the discovery potential of the TEXONO and COHERENT experiments to subleading sterile neutrino effects through the measurement of the coherent elastic neutrino-nucleus scattering event rate. Our dedicated χ2-sensitivity analysis employs realistic nuclear structure calculations adequate for high purity sub-keV threshold Germanium detectors.

A search for hep solar neutrinos at the Sudbury Neutrino Observatory

NASA Astrophysics Data System (ADS)

Winchester, Timothy J.

Solar neutrinos from the fusion hep reaction, (helium-3 fusing with a proton to become helium-4, releasing a positron and neutrino), have previously remained undetected due to their flux being about one one-thousandth that of boron-8 neutrinos. These neutrinos are interesting theoretically because they are less dependent on solar composition than other solar neutrinos, and therefore provide a somewhat independent test of the Standard Solar Model. In this analysis, we develop a new event fitter for existing data from the Sudbury Neutrino Observatory. We also use the fitter to remove backgrounds that previously limited the fiducial volume, which we increase by 30%. We use a modified Wald-Wolfowitz test to increase the amount of live time by 200 days (18%) and show that this data is consistent with the previously-used data. Finally, we develop a Bayesian analysis technique to make full use of the posterior distributions of energy returned by the event fitter. In the first significant detection of hep neutrinos, we find that the most-probable rate of hep events is 3.5 x 10. 4 /cm. 2/s, which is significantly higher than the theoretical prediction. We find that the 95% credible region extends from 1.0 to 7.2 x 10. 4 /cm. 2/s, and that we can therefore exclude a rate of 0 hep events at greater than 95% probability.

Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction

PubMed Central

Tugaeva, Kristina V.; Tsvetkov, Philipp O.

2017-01-01

Abundant regulatory 14-3-3 proteins have an extremely wide interactome and coordinate multiple cellular events via interaction with specifically phosphorylated partner proteins. Notwithstanding the key role of 14-3-3/phosphotarget interactions in many physiological and pathological processes, they are dramatically underexplored. Here, we focused on the 14-3-3 interaction with human Tau protein associated with the development of several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Among many known phosphorylation sites within Tau, protein kinase A (PKA) phosphorylates several key residues of Tau and induces its tight interaction with 14-3-3 proteins. However, the stoichiometry and mechanism of 14-3-3 interaction with phosphorylated Tau (pTau) are not clearly elucidated. In this work, we describe a simple bacterial co-expression system aimed to facilitate biochemical and structural studies on the 14-3-3/pTau interaction. We show that dual co-expression of human fetal Tau with PKA in Escherichia coli results in multisite Tau phosphorylation including also naturally occurring sites which were not previously considered in the context of 14-3-3 binding. Tau protein co-expressed with PKA displays tight functional interaction with 14-3-3 isoforms of a different type. Upon triple co-expression with 14-3-3 and PKA, Tau protein could be co-purified with 14-3-3 and demonstrates complex which is similar to that formed in vitro between individual 14-3-3 and pTau obtained from dual co-expression. Although used in this study for the specific case of the previously known 14-3-3/pTau interaction, our co-expression system may be useful to study of other selected 14-3-3/phosphotarget interactions and for validations of 14-3-3 complexes identified by other methods. PMID:28575131

Tau Kinetics in Neurons and the Human Central Nervous System.

PubMed

Sato, Chihiro; Barthélemy, Nicolas R; Mawuenyega, Kwasi G; Patterson, Bruce W; Gordon, Brian A; Jockel-Balsarotti, Jennifer; Sullivan, Melissa; Crisp, Matthew J; Kasten, Tom; Kirmess, Kristopher M; Kanaan, Nicholas M; Yarasheski, Kevin E; Baker-Nigh, Alaina; Benzinger, Tammie L S; Miller, Timothy M; Karch, Celeste M; Bateman, Randall J

2018-03-21

We developed stable isotope labeling and mass spectrometry approaches to measure the kinetics of multiple isoforms and fragments of tau in the human central nervous system (CNS) and in human induced pluripotent stem cell (iPSC)-derived neurons. Newly synthesized tau is truncated and released from human neurons in 3 days. Although most tau proteins have similar turnover, 4R tau isoforms and phosphorylated forms of tau exhibit faster turnover rates, suggesting unique processing of these forms that may have independent biological activities. The half-life of tau in control human iPSC-derived neurons is 6.74 ± 0.45 days and in human CNS is 23 ± 6.4 days. In cognitively normal and Alzheimer's disease participants, the production rate of tau positively correlates with the amount of amyloid plaques, indicating a biological link between amyloid plaques and tau physiology. Copyright © 2018 Elsevier Inc. All rights reserved.

A search for matter enhanced neutrino oscillations through measurements of day and night solar neutrino fluxes at the Sudbury Neutrino Observatory

NASA Astrophysics Data System (ADS)

Miknaitis, Kathryn Kelly Schaffer

The Sudbury Neutrino Observatory (SNO) is a heavy-water Cherenkov detector designed to study 8B neutrinos from the sun. Through the charged-current (CC) and neutral-current (NC) reactions of neutrinos on deuterium, SNO separately determines the flux of electron neutrinos and the flux of all active flavors of solar 8B neutrinos. SNO is also sensitive to the elastic scattering (ES) of neutrinos on electrons in the heavy water. Measurements of the CC and NC rates in SNO have conclusively demonstrated solar neutrino flavor change. This flavor change is believed to be caused by matter-enhanced oscillations in the sun, through the Mikheyev-Smirnov-Wolfenstein (MSW) effect. Matter effects could also change the flavor composition of neutrinos that traverse the earth. A comparison of the day and night measured CC flux at SNO directly tests for the MSW effect and contributes to constraints on neutrino oscillation parameters in the MSW model. We perform measurements of the day and night neutrino fluxes using data from the second phase of SNO, in which salt (NaCl) was added to the heavy water to enhance sensitivity to the NC reaction. Better discrimination between CC and NC events in the salt phase allows the fluxes to be determined without constraining the neutrino energy spectrum. The day-night asymmetry in the CC flux measured in this model-independent analysis is ACC = [-5.6 +/- 7.4(stat.) +/- 5.3(syst.)]%, where the asymmetry is defined as the difference between the night and day values divided by their average. The asymmetries in the NC and ES fluxes are ANC = [4.2 +/- 8.6(stat.) +/- 7.2(syst.)]%, and AES = (14.6 +/- 19.8(stat.) +/- 3.3(syst.)]%. The neutral current asymmetry is expected to be zero assuming standard neutrino oscillations. When we constrain it to be zero, we obtain ACC = [-3.7 +/- 6.3(stat.) +/- 3.2(syst.)]% and AES = [15.3 +/- 19.8(stat.) +/- 3.0(syst.)]%. The day and night energy spectra from the CC reaction have been measured and show no evidence for

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

PubMed Central

Chai, Xiyun; Wu, Su; Murray, Tracey K.; Kinley, Robert; Cella, Claire V.; Sims, Helen; Buckner, Nicola; Hanmer, Jenna; Davies, Peter; O'Neill, Michael J.; Hutton, Michael L.; Citron, Martin

2011-01-01

The microtubule-associated protein Tau plays a critical role in the pathogenesis of Alzheimer disease and several related disorders (tauopathies). In the disease Tau aggregates and becomes hyperphosphorylated forming paired helical and straight filaments, which can further condense into higher order neurofibrillary tangles in neurons. The development of this pathology is consistently associated with progressive neuronal loss and cognitive decline. The identification of tractable therapeutic targets in this pathway has been challenging, and consequently very few clinical studies addressing Tau pathology are underway. Recent active immunization studies have raised the possibility of modulating Tau pathology by activating the immune system. Here we report for the first time on passive immunotherapy for Tau in two well established transgenic models of Tau pathogenesis. We show that peripheral administration of two antibodies against pathological Tau forms significantly reduces biochemical Tau pathology in the JNPL3 mouse model. We further demonstrate that peripheral administration of the same antibodies in the more rapidly progressive P301S tauopathy model not only reduces Tau pathology quantitated by biochemical assays and immunohistochemistry, but also significantly delays the onset of motor function decline and weight loss. This is accompanied by a reduction in neurospheroids, providing direct evidence of reduced neurodegeneration. Thus, passive immunotherapy is effective at preventing the buildup of intracellular Tau pathology, neurospheroids, and associated symptoms, although the exact mechanism remains uncertain. Tau immunotherapy should therefore be considered as a therapeutic approach for the treatment of Alzheimer disease and other tauopathies. PMID:21841002

Probing secret interactions of eV-scale sterile neutrinos with the diffuse supernova neutrino background

NASA Astrophysics Data System (ADS)

Jeong, Yu Seon; Palomares-Ruiz, Sergio; Hall Reno, Mary; Sarcevic, Ina

2018-06-01

Sterile neutrinos with mass in the eV-scale and large mixings of order θ0simeq 0.1 could explain some anomalies found in short-baseline neutrino oscillation data. Here, we revisit a neutrino portal scenario in which eV-scale sterile neutrinos have self-interactions via a new gauge vector boson phi. Their production in the early Universe via mixing with active neutrinos can be suppressed by the induced effective potential in the sterile sector. We study how different cosmological observations can constrain this model, in terms of the mass of the new gauge boson, Mphi, and its coupling to sterile neutrinos, gs. Then, we explore how to probe part of the allowed parameter space of this particular model with future observations of the diffuse supernova neutrino background by the Hyper-Kamiokande and DUNE detectors. For Mphi ~ 5‑10 keV and gs ~ 10‑4‑10‑2, as allowed by cosmological constraints, we find that interactions of diffuse supernova neutrinos with relic sterile neutrinos on their way to the Earth would result in significant dips in the neutrino spectrum which would produce unique features in the event spectra observed in these detectors.

Hardron production and neutrino beams

NASA Astrophysics Data System (ADS)

Guglielmi, A.

2006-11-01

The precise measurements of the neutrino mixing parameters in the oscillation experiments at accelerators require new high-intensity and high-purity neutrino beams. Ancillary hadron-production measurements are then needed as inputs to precise calculation of neutrino beams and of atmospheric neutrino fluxes.

Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.

PubMed

Tracy, Tara E; Gan, Li

2018-05-09

The accumulation of pathological tau in the brain is associated with neuronal deterioration and cognitive impairments in tauopathies including Alzheimer's disease. Tau, while primarily localized in the axons of healthy neurons, accumulates in the soma and dendrites of neurons under pathogenic conditions. Tau is found in both presynaptic and postsynaptic compartments of neurons in Alzheimer's disease. New research supports that soluble forms of tau trigger pathophysiology in the brain by altering properties of synaptic and neuronal function at the early stages of disease progression, before neurons die. Here we review the current understanding of how tau-mediated synaptic and neuronal dysfunction contributes to cognitive decline. Delineating the mechanisms by which pathogenic tau alters synapses, dendrites and axons will help lay the foundation for new strategies that can restore neuronal function in tauopathy. Copyright © 2018 Elsevier Ltd. All rights reserved.

Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging.

PubMed

Maass, Anne; Lockhart, Samuel N; Harrison, Theresa M; Bell, Rachel K; Mellinger, Taylor; Swinnerton, Kaitlin; Baker, Suzanne L; Rabinovici, Gil D; Jagust, William J

2018-01-17

The medial temporal lobe (MTL) is an early site of tau accumulation and MTL dysfunction may underlie episodic-memory decline in aging and dementia. Postmortem data indicate that tau pathology in the transentorhinal cortex is common by age 60, whereas spread to neocortical regions and worsening of cognition is associated with β-amyloid (Aβ). We used [ 18 F]AV-1451 and [ 11 C]PiB positron emission tomography, structural MRI, and neuropsychological assessment to investigate how in vivo tau accumulation in temporal lobe regions, Aβ, and MTL atrophy contribute to episodic memory in cognitively normal older adults ( n = 83; age, 77 ± 6 years; 58% female). Stepwise regressions identified tau in MTL regions known to be affected in old age as the best predictor of episodic-memory performance independent of Aβ status. There was no interactive effect of MTL tau with Aβ on memory. Higher MTL tau was related to higher age in the subjects without evidence of Aβ. Among temporal lobe subregions, episodic memory was most strongly related to tau-tracer uptake in the parahippocampal gyrus, particularly the posterior entorhinal cortex, which in our parcellation includes the transentorhinal cortex. In subjects with longitudinal MRI and cognitive data ( n = 57), entorhinal atrophy mirrored patterns of tau pathology and their relationship with memory decline. Our data are consistent with neuropathological studies and further suggest that entorhinal tau pathology underlies memory decline in old age even without Aβ. SIGNIFICANCE STATEMENT Tau tangles and β-amyloid (Aβ) plaques are key lesions in Alzheimer's disease (AD) but both pathologies also occur in cognitively normal older people. Neuropathological data indicate that tau tangles in the medial temporal lobe (MTL) underlie episodic-memory impairments in AD dementia. However, it remains unclear whether MTL tau pathology also accounts for memory impairments often seen in elderly people and how Aβ affects this relationship

Anesthesia and Tau Pathology

PubMed Central

Whittington, Robert A.; Bretteville, Alexis; Dickler, Maya F.; Planel, Emmanuel

2013-01-01

Alzheimer’s disease (AD) is the most common form of dementia and remains a growing worldwide health problem. As life expectancy continues to increase, the number of AD patients presenting for surgery and anesthesia will steadily rise. The etiology of sporadic AD is thought to be multifactorial, with environmental, biological and genetic factors interacting together to influence AD pathogenesis. Recent reports suggest that general anesthetics may be such a factor and may contribute to the development and exacerbation of this neurodegenerative disorder. Intra-neuronal neurofibrillary tangles (NFT), composed of hyperphosphorylated and aggregated tau protein are one of the main neuropathological hallmarks of AD. Tau pathology is important in AD as it correlates very well with cognitive dysfunction. Lately, several studies have begun to elucidate the mechanisms by which anesthetic exposure might affect the phosphorylation, aggregation and function of this microtubule-associated protein. Here, we specifically review the literature detailing the impact of anesthetic administration on aberrant tau hyperphosphorylation as well as the subsequent development of neurofibrillary pathology and degeneration. PMID:23535147

Neutrino mixing and big bang nucleosynthesis

NASA Astrophysics Data System (ADS)

Bell, Nicole

2003-04-01

We analyse active-active neutrino mixing in the early universe and show that transformation of neutrino-antineutrino asymmetries between flavours is unavoidable when neutrino mixing angles are large. This process is a standard Mikheyev-Smirnov-Wolfenstein flavour transformation, modified by the synchronisation of momentum states which results from neutrino-neutrino forward scattering. The new constraints placed on neutrino asymmetries eliminate the possibility of degenerate big bang nucleosynthesis.Implications of active-sterile neutrino mixing will also be reviewed.

Probing neutrino coupling to a light scalar with coherent neutrino scattering

NASA Astrophysics Data System (ADS)

Farzan, Yasaman; Lindner, Manfred; Rodejohann, Werner; Xu, Xun-Jie

2018-05-01

Large neutrino event numbers in future experiments measuring coherent elastic neutrino nucleus scattering allow precision measurements of standard and new physics. We analyze the current and prospective limits of a light scalar particle coupling to neutrinos and quarks, using COHERENT and CONUS as examples. Both lepton number conserving and violating interactions are considered. It is shown that current (future) experiments can probe for scalar masses of a few MeV couplings down to the level of 10-4 (10-6). Scalars with masses around the neutrino energy allow to determine their mass via a characteristic spectrum shape distortion. Our present and future limits are compared with constraints from supernova evolution, Big Bang nucleosynthesis and neutrinoless double beta decay. We also outline UV-complete underlying models that include a light scalar with coupling to quarks for both lepton number violating and conserving coupling to neutrinos.

Evidence of electron neutrino appearance in a muon neutrino beam

NASA Astrophysics Data System (ADS)

Abe, K.; Abgrall, N.; Aihara, H.; Akiri, T.; Albert, J. B.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Ariga, T.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bass, M.; Batkiewicz, M.; Bay, F.; Bentham, S. W.; Berardi, V.; Berger, B. E.; Berkman, S.; Bertram, I.; Beznosko, D.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Boyd, S.; Brailsford, D.; Bravar, A.; Bronner, C.; Brook-Roberge, D. G.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Curioni, A.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; Day, M.; de André, J. P. A. M.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S.; Densham, C.; Di Lodovico, F.; Di Luise, S.; Dobson, J.; Drapier, O.; Duboyski, T.; Dufour, F.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Dziomba, M.; Emery, S.; Ereditato, A.; Escudero, L.; Finch, A. J.; Frank, E.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A.; Galymov, V.; Gaudin, A.; Giffin, S.; Giganti, C.; Gilje, K.; Golan, T.; Gomez-Cadenas, J. J.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Ives, S. J.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Johnson, R. A.; Jo, J. H.; Jonsson, P.; Joo, K. K.; Jung, C. K.; Kaboth, A.; Kaji, H.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Kearns, E.; Khabibullin, M.; Khanam, F.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J. Y.; Kim, J.; Kim, S. B.; Kirby, B.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Kogan, G.; Kolaceke, A.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kowalik, K.; Kreslo, I.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kumaratunga, S.; Kurjata, R.; Kutter, T.; Lagoda, J.; Laihem, K.; Laing, A.; Laveder, M.; Lawe, M.; Lazos, M.; Lee, K. P.; Licciardi, C.; Lim, I. T.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Lopez, G. D.; Ludovici, L.; Macaire, M.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marchionni, A.; Marino, A. D.; Marteau, J.; Martin, J. F.; Maruyama, T.; Marzec, J.; Masliah, P.; Mathie, E. L.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCauley, N.; McFarland, K. S.; McGrew, C.; McLachlan, T.; Messina, M.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Mine, S.; Missert, A.; Miura, M.; Monfregola, L.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nagasaki, T.; Nakadaira, T.; Nakahata, M.; Nakai, T.; Nakajima, K.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Naples, D.; Nicholls, T. C.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; O'Keeffe, H. M.; Obayashi, Y.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Otani, M.; Owen, R. A.; Oyama, Y.; Pac, M. Y.; Palladino, V.; Paolone, V.; Payne, D.; Pearce, G. F.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pinzon Guerra, E. S.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Reeves, M.; Reinherz-Aronis, E.; Retiere, F.; Robert, A.; Rodrigues, P. A.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sakashita, K.; Sánchez, F.; Scantamburlo, E.; Scholberg, K.; Schwehr, J.; Scott, M.; Scully, D. I.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shibata, M.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smith, R. J.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Szeglowski, T.; Szeptycka, M.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. A.; Tanaka, M. M.; Tanaka, M.; Taylor, I. J.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Ueno, K.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yen, S.; Yershov, N.; Yokoyama, M.; Yuan, T.; Zalewska, A.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.

2013-08-01

The T2K Collaboration reports evidence for electron neutrino appearance at the atmospheric mass splitting, |Δm322|≈2.4×10-3eV2. An excess of electron neutrino interactions over background is observed from a muon neutrino beam with a peak energy of 0.6 GeV at the Super-Kamiokande (SK) detector 295 km from the beam’s origin. Signal and background predictions are constrained by data from near detectors located 280 m from the neutrino production target. We observe 11 electron neutrino candidate events at the SK detector when a background of 3.3±0.4(syst) events is expected. The background-only hypothesis is rejected with a p value of 0.0009 (3.1σ), and a fit assuming νμ→νe oscillations with sin⁡22θ23=1, δCP=0 and |Δm322|=2.4×10-3eV2 yields sin⁡22θ13=0.088-0.039+0.049(stat+syst).

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies.

PubMed

Dai, Chun-ling; Chen, Xia; Kazim, Syed Faraz; Liu, Fei; Gong, Cheng-Xin; Grundke-Iqbal, Inge; Iqbal, Khalid

2015-04-01

Intraneuronal accumulation of abnormally hyperphosphorylated tau in the brain is a histopathological hallmark of Alzheimer's disease and a family of related neurodegenerative disorders collectively called tauopathies. At present there is no effective treatment available for these progressive neurodegenerative diseases which are clinically characterized by dementia in mid to old-age. Here we report the treatment of 14-17-months-old 3xTg-AD mice with tau antibodies 43D (tau 6-18) and 77E9 (tau 184-195) to the N-terminal projection domain of tau or mouse IgG as a control by intraperitoneal injection once a week for 4 weeks, and the effects of the passive immunization on reduction of hyperphosphorylated tau, Aβ accumulation and cognitive performance in these animals. We found that treatment with tau antibodies 43D and 77E9 reduced total tau level, decreased tau hyperphosphorylated at Ser199, Ser202/Thr205 (AT8), Thr205, Ser262/356 (12E8), and Ser396/404 (PHF-1) sites, and a trend to reduce Aβ pathology. Most importantly, targeting N-terminal tau especially by 43D (tau 6-18) improved reference memory in the Morris water maze task in 3xTg-AD mice. We did not observe any abnormality in general physical characteristics of the treated animals with either of the two antibodies during the course of this study. Taken together, our studies demonstrate for the first time (1) that passive immunization targeting normal tau can effectively clear the hyperphosphorylated protein and possibly reduce Aβ pathology from the brain and (2) that targeting N-terminal projection domain of tau containing amino acid 6-18 is especially beneficial. Thus, targeting selective epitopes of N-terminal domain of tau may present a novel effective therapeutic opportunity for Alzheimer disease and other tauopathies.

Sterile Neutrinos in Cold Climates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, Benjamin J.P.

Measurements of neutrino oscillations at short baselines contain an intriguing set of experimental anomalies that may be suggestive of new physics such as the existence of sterile neutrinos. This three-part thesis presents research directed towards understanding these anomalies and searching for sterile neutrino oscillations. Part I contains a theoretical discussion of neutrino coherence properties. The open-quantum-system picture of neutrino beams, which allows a rigorous prediction of coherence distances for accelerator neutrinos, is presented. Validity of the standard treatment of active and sterile neutrino oscillations at short baselines is verified, and non-standard coherence loss effects at longer baselines are predicted. Partmore » II concerns liquid argon detector development for the MicroBooNE experiment, which will search for short-baseline oscillations in the Booster Neutrino Beam at Fermilab. Topics include characterization and installation of the MicroBooNE optical system; test-stand measurements of liquid argon optical properties with dissolved impurities; optimization of wavelength-shifting coatings for liquid argon scintillation light detection; testing and deployment of high-voltage surge arrestors to protect TPC field cages; and software development for optical and TPC simulation and reconstruction. Part III presents a search for sterile neutrinos using the IceCube neutrino telescope, which has collected a large sample of atmospheric-neutrino-induced events in the 1-10 TeV energy range. Sterile neutrinos would modify the detected neutrino flux shape via MSW-resonant oscillations. Following a careful treatment of systematic uncertainties in the sample, no evidence for MSW-resonant oscillations is observed, and exclusion limits on 3+1 model parameter space are derived. Under the mixing assumptions made, the 90% confidence level exclusion limit extends to sin 22θ 24 ≤ 0.02 at m 2 ~ 0.3 eV 2, and the LSND and MiniBooNE allowed regions are

Hybrid method to resolve the neutrino mass hierarchy by supernova (anti)neutrino induced reactions

NASA Astrophysics Data System (ADS)

Vale, D.; Rauscher, T.; Paar, N.

2016-02-01

We introduce a hybrid method to determine the neutrino mass hierarchy by simultaneous measurements of responses of at least two detectors to antineutrino and neutrino fluxes from accretion and cooling phases of core-collapse supernovae. The (anti)neutrino-nucleus cross sections for 56Fe and 208Pb are calculated in the framework of the relativistic nuclear energy density functional and weak interaction Hamiltonian, while the cross sections for inelastic scattering on free protons p(bar nue,e+)n are obtained using heavy-baryon chiral perturbation theory. The modelling of (anti)neutrino fluxes emitted from a protoneutron star in a core-collapse supernova include collective and Mikheyev-Smirnov-Wolfenstein effects inside the exploding star. The particle emission rates from the elementary decay modes of the daughter nuclei are calculated for normal and inverted neutrino mass hierarchy. It is shown that simultaneous use of (anti)neutrino detectors with different target material allows to determine the neutrino mass hierarchy from the ratios of νe- and bar nue-induced particle emissions. This hybrid method favors neutrinos from the supernova cooling phase and the implementation of detectors with heavier target nuclei (208Pb) for the neutrino sector, while for antineutrinos the use of free protons in mineral oil or water is the appropriate choice.

ELISA measurement of specific antibodies to phosphorylated tau in intravenous immunoglobulin products.

PubMed

Loeffler, David A; Klaver, Andrea C; Coffey, Mary P

2015-10-01

The therapeutic effects of intravenous immunoglobulin (IVIG) products were recently studied in Alzheimer's disease (AD) patients. Pilot studies produced encouraging results but phase II and III trials gave disappointing results; a further study is in progress. IVIG products contain antibodies to tau protein, the main component of neurofibrillary tangles (NFTs). The tau used to detect IVIG's anti-tau antibodies in previous studies was non-phosphorylated recombinant human tau-441, but NFT-associated tau is extensively phosphorylated. The objective of this study was to determine if various IVIG products contain specific antibodies to phosphorylated tau (anti-pTau antibodies). ELISAs were used to evaluate binding of six IVIG products to a 12 amino acid peptide, tau 196-207, which was phosphorylated ("pTau peptide") or non-phosphorylated ("non-pTau peptide") at Serine-199 and Serine-202. Both amino acid residues are phosphorylated in AD NFTs. Each IVIG's "anti-pTau antibody ratio" was calculated by dividing its binding to the pTau peptide by its binding to the non-pTau peptide. Seven experiments were performed and data were pooled, with each experiment contributing one data point from each IVIG product. Mean anti-pTau antibody ratios greater than 1.0, suggesting specific antibodies to phosphorylated tau, were found for three IVIG products. Because administration of antibodies to phosphorylated tau has been found to reduce tau-associated pathology in transgenic mouse models of tauopathy, increasing the levels of anti-pTau antibodies, together with other selected antibodies such as anti-Aβ, in IVIG might increase its ability to slow AD's progression. Copyright © 2015 Elsevier B.V. All rights reserved.

Event identification for KM3NeT/ARCA

NASA Astrophysics Data System (ADS)

Heid, Thomas; KM3NeT Collaboration

2017-09-01

KM3NeT is a large research infrastructure consisting of a network of deep-sea neutrino telescopes. KM3NeT/ARCA will be the instrument detecting high-energy neutrinos with energies above 100 TeV. This instrument gives a new opportunity to observe the neutrino sky with very high angular resolution to be able to detect neutrino point sources. Furthermore it will be possible to probe the flavour composition of neutrino fluxes, and hence production mechanisms, with so-far unreached precision. Neutrinos produce different event topologies in the detector according to their flavour, interaction channel and deposited energy. Machine-learning algorithms are able to learn features of topologies to discriminate them. In previous analyses only two event types were regarded, namely the shower and track topology. With good timing resolution and precise reconstruction algorithms it is possible to separate into more event types, for example the double bang topology produced by tau neutrinos. The final goal is to distinguish all three neutrino flavors as much as possible. To resolve this issue the KM3NeT collaboration uses deep neural networks trained with Monte Carlo events of all neutrino types. This contribution shows the ability of KM3NeT/ARCA to classify events in more than two neutrino event topologies. Furthermore, the borders between detectable classes are shown, such as the minimum distance the tau has to travel before decaying into a tau neutrino to be detected as double bang event.

Neutrino Oscillations at Proton Accelerators

NASA Astrophysics Data System (ADS)

Michael, Douglas

2002-12-01

Data from many different experiments have started to build a first glimpse of the phenomenology associated with neutrino oscillations. Results on atmospheric and solar neutrinos are particularly clear while a third result from LSND suggests a possibly very complex oscillation phenomenology. As impressive as the results from current experiments are, it is clear that we are just getting started on a long-term experimental program to understand neutrino masses, mixings and the physics which produce them. A number of exciting fundamental physics possibilities exist, including that neutrino oscillations could demonstrate CP or CPT violation and could be tied to exotic high-energy phenomena including strings and extra dimensions. A complete exploration of oscillation phenomena demands many experiments, including those possible using neutrino beams produced at high energy proton accelerators. Most existing neutrino experiments are statistics limited even though they use gigantic detectors. High intensity proton beams are essential for producing the intense neutrino beams which we need for next generation neutrino oscillation experiments.

Simulating nonlinear neutrino flavor evolution

NASA Astrophysics Data System (ADS)

Duan, H.; Fuller, G. M.; Carlson, J.

2008-10-01

We discuss a new kind of astrophysical transport problem: the coherent evolution of neutrino flavor in core collapse supernovae. Solution of this problem requires a numerical approach which can simulate accurately the quantum mechanical coupling of intersecting neutrino trajectories and the associated nonlinearity which characterizes neutrino flavor conversion. We describe here the two codes developed to attack this problem. We also describe the surprising phenomena revealed by these numerical calculations. Chief among these is that the nonlinearities in the problem can engineer neutrino flavor transformation which is dramatically different to that in standard Mikheyev Smirnov Wolfenstein treatments. This happens even though the neutrino mass-squared differences are measured to be small, and even when neutrino self-coupling is sub-dominant. Our numerical work has revealed potential signatures which, if detected in the neutrino burst from a Galactic core collapse event, could reveal heretofore unmeasurable properties of the neutrinos, such as the mass hierarchy and vacuum mixing angle θ13.

Imbalance of Hsp70 family variants fosters tau accumulation.

PubMed

Jinwal, Umesh K; Akoury, Elias; Abisambra, Jose F; O'Leary, John C; Thompson, Andrea D; Blair, Laura J; Jin, Ying; Bacon, Justin; Nordhues, Bryce A; Cockman, Matthew; Zhang, Juan; Li, Pengfei; Zhang, Bo; Borysov, Sergiy; Uversky, Vladimir N; Biernat, Jacek; Mandelkow, Eckhard; Gestwicki, Jason E; Zweckstetter, Markus; Dickey, Chad A

2013-04-01

Dysfunctional tau accumulation is a major contributing factor in tauopathies, and the heat-shock protein 70 (Hsp70) seems to play an important role in this accumulation. Several reports suggest that Hsp70 proteins can cause tau degradation to be accelerated or slowed, but how these opposing activities are controlled is unclear. Here we demonstrate that highly homologous variants in the Hsp70 family can have opposing effects on tau clearance kinetics. When overexpressed in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively. Tau synergized with Hsc70, but not Hsp72, to promote microtubule assembly at nearly twice the rate of either Hsp70 homologue in reconstituted, ATP-regenerating Xenopus extracts supplemented with rhodamine-labeled tubulin and human recombinant Hsp72 and Hsc70. Nuclear magnetic resonance spectroscopy with human recombinant protein revealed that Hsp72 had greater affinity for tau than Hsc70 (I/I0 ratio difference of 0.3), but Hsc70 was 30 times more abundant than Hsp72 in human and mouse brain tissue. This indicates that the predominant Hsp70 variant in the brain is Hsc70, suggesting that the brain environment primarily supports slower tau clearance. Despite its capacity to clear tau, Hsp72 was not induced in the Alzheimer's disease brain, suggesting a mechanism for age-associated onset of the disease. Through the use of chimeras that blended the domains of Hsp72 and Hsc70, we determined that the reason for these differences between Hsc70 and Hsp72 with regard to tau clearance kinetics lies within their C-terminal domains, which are essential for their interactions with substrates and cochaperones. Hsp72 but not Hsc70 in the presence of tau was able to recruit the cochaperone ubiquitin ligase CHIP, which is known to facilitate the ubiquitination of tau, describing a possible mechanism of how the C-termini of these homologous Hsp70 variants

Sterile Neutrino Search with MINOS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devan, Alena V.

2015-08-01

MINOS, Main Injector Neutrino Oscillation Search, is a long-baseline neutrino oscillation experiment in the NuMI muon neutrino beam at the Fermi National Accelerator Laboratory in Batavia, IL. It consists of two detectors, a near detector positioned 1 km from the source of the beam and a far detector 734 km away in Minnesota. MINOS is primarily designed to observe muon neutrino disappearance resulting from three flavor oscillations. The Standard Model of Particle Physics predicts that neutrinos oscillate between three active flavors as they propagate through space. This means that a muon-type neutrino has a certain probability to later interact asmore » a different type of neutrino. In the standard picture, the neutrino oscillation probabilities depend only on three neutrino flavors and two mass splittings, Δm 2. An anomaly was observed by the LSND and MiniBooNE experiments that suggests the existence of a fourth, sterile neutrino flavor that does not interact through any of the known Standard Model interactions. Oscillations into a theoretical sterile flavor may be observed by a deficit in neutral current interactions in the MINOS detectors. A distortion in the charged current energy spectrum might also be visible if oscillations into the sterile flavor are driven by a large mass-squared difference, m s 2 ~ 1 eV 2. The results of the 2013 sterile neutrino search are presented here.« less

Amyloid and tau cerebrospinal fluid biomarkers in HIV infection.

PubMed

Gisslén, Magnus; Krut, Jan; Andreasson, Ulf; Blennow, Kaj; Cinque, Paola; Brew, Bruce J; Spudich, Serena; Hagberg, Lars; Rosengren, Lars; Price, Richard W; Zetterberg, Henrik

2009-12-22

Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients. In this cross-sectional study we measured soluble amyloid precursor proteins alpha and beta (sAPPalpha and sAPPbeta), amyloid beta fragment 1-42 (Abeta1-42), and total and hyperphosphorylated tau (t-tau and p-tau) in CSF of 86 HIV-infected (HIV+) subjects, including 21 with AIDS dementia complex (ADC), 25 with central nervous system (CNS) opportunistic infections and 40 without neurological symptoms and signs. We also measured these CSF biomarkers in 64 uninfected (HIV-) subjects, including 21 with Alzheimer's disease, and both younger and older controls without neurological disease. CSF sAPPalpha and sAPPbeta concentrations were highly correlated and reduced in patients with ADC and opportunistic infections compared to the other groups. The opportunistic infection group but not the ADC patients had lower CSF Abeta1-42 in comparison to the other HIV+ subjects. CSF t-tau levels were high in some ADC patients, but did not differ significantly from the HIV+ neuroasymptomatic group, while CSF p-tau was not increased in any of the HIV+ groups. Together, CSF amyloid and tau markers segregated the ADC patients from both HIV+ and HIV- neuroasymptomatics and from Alzheimer's disease patients, but not from those with opportunistic infections. Parallel reductions of CSF sAPPalpha and sAPPbeta in ADC and CNS opportunistic infections suggest an effect of CNS immune activation or inflammation on neuronal amyloid synthesis or processing. Elevation of CSF t-tau in some ADC and CNS infection patients without concomitant increase in p-tau indicates neural injury without preferential accumulation of hyperphosphorylated tau as found in Alzheimer's disease. These biomarker changes define pathogenetic pathways to brain injury in ADC that differ from those of Alzheimer's disease.

Observing Muon Neutrino to Electron Neutrino Oscillations in the NOνA Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xin, Tian

2016-01-01

Neutrino oscillations offers an insight on new physics beyond the Standard Model. The three mixing angles (θ12, θ13 and θ23) and the two mass splittings (Δm2 and Αm2 ) have been measured by different neutrino oscillation experiments. Some other parameters including the mass ordering of different neutrino mass eigenstates and the CP violation phase are still unknown. NOνA is a long-baseline accelerator neutrino experiment, using neutrinos from the NuMI beam at Fermilab. The experiment is equipped with two functionally identical detectors about 810 kilometers apart and 14 mrad off the beam axis. In this configuration, the muon neutrinos from themore » NuMI beam reach the disappearance maximum in the far detector and a small fraction of that oscillates into electron neutrinos. The sensitivity to the mass ordering and CP viola- tion phase determination is greately enhanced. This thesis presents the νeappearance analysis using the neutrino data collected with the NOνA experiment between February 2014 and May 2015, which corresponds to 3.45 ×1020 protons-on-target (POT). The νe appearance analysis is performed by comparing the observed νe CC-like events to the estimated background at the far detector. The total background is predicted to be 0.95 events with 0.89 originated from beam events and 0.06 from cosmic ray events. The beam background is obtained by extrapolating near detector data through different oscillation channels, while the cosmic ray background is calculated based on out-of-time NuMI trigger data. A total of 6 electron neutrino candidates are observed in the end at the far detector which represents 3.3 σ excess over the predicted background. The NOνA result disfavors inverted mass hierarchy for δcp ϵ [0, 0.6π] at 90% C.L.« less

Matter effects on the flavor conversions of solar neutrinos and high-energy astrophysical neutrinos

NASA Astrophysics Data System (ADS)

Huang, Guo-yuan; Liu, Jun-Hao; Zhou, Shun

2018-06-01

Can we observe the solar eclipses in the neutrino light? In principle, this is possible by identifying the lunar matter effects on the flavor conversions of solar neutrinos when they traverse the Moon before reaching the detectors at the Earth. Unfortunately, we show that the lunar matter effects on the survival probability of solar 8B neutrinos are suppressed by an additional factor of 1.2%, compared to the day-night asymmetry. However, we point out that the matter effects on the flavor conversions of high-energy astrophysical neutrinos, when they propagate through the Sun, can be significant. Though the flavor composition of high-energy neutrinos can be remarkably modified, it is quite challenging to observe such effects even in the next-generation of neutrino telescopes.

Neutrino mass hierarchy and three-flavor spectral splits of supernova neutrinos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dasgupta, Basudeb; Mirizzi, Alessandro; Tomas, Ricard

2010-05-01

It was recently realized that three-flavor effects could peculiarly modify the development of spectral splits induced by collective oscillations, for supernova neutrinos emitted during the cooling phase of a protoneutron star. We systematically explore this case, explaining how the impact of these three-flavor effects depends on the ordering of the neutrino masses. In inverted mass hierarchy, the solar mass splitting gives rise to instabilities in regions of the (anti)neutrino energy spectra that were otherwise stable under the leading two-flavor evolution governed by the atmospheric mass splitting and by the 1-3 mixing angle. As a consequence, the high-energy spectral splits foundmore » in the electron (anti)neutrino spectra disappear, and are transferred to other flavors. Imperfect adiabaticity leads to smearing of spectral swap features. In normal mass hierarchy, the three-flavor and the two-flavor instabilities act in the same region of the neutrino energy spectrum, leading to only minor departures from the two-flavor treatment.« less

A comprehensive study of neutrino spin-flavour conversion in supernovae and the neutrino mass hierarchy

NASA Astrophysics Data System (ADS)

Ando, Shin'ichiro; Sato, Katsuhiko

2003-10-01

Resonant spin-flavour (RSF) conversions of supernova neutrinos, which are induced by the interaction between the nonzero neutrino magnetic moment and supernova magnetic fields, are studied for both normal and inverted mass hierarchy. As the case for the pure matter-induced neutrino oscillation (Mikheyev–Smirnov–Wolfenstein (MSW) effect), we find that the RSF transitions are strongly dependent on the neutrino mass hierarchy as well as the value of θ13. Flavour conversions are solved numerically for various neutrino parameter sets, with the presupernova profile calculated by Woosley and Weaver. In particular, it is very interesting that the RSF-induced νe→bar nue transition occurs if the following conditions are all satisfied: the value of μνB (μν is the neutrino magnetic moment and B is the magnetic field strength) is sufficiently strong, the neutrino mass hierarchy is inverted, and the value of θ13 is large enough to induce adiabatic MSW resonance. In this case, the strong peak due to the original νe emitted from the neutronization burst would exist in the time profile of the neutrino events detected at the Super-Kamiokande detector. If this peak were observed in reality, it would provide fruitful information on the neutrino properties. On the other hand, the characteristics of the neutrino spectra are also different between the neutrino models, but we find that there remains degeneracy among several models. Dependence on presupernova models is also discussed.

Harnessing the immune system for treatment and detection of tau pathology.

PubMed

Congdon, Erin E; Krishnaswamy, Senthilkumar; Sigurdsson, Einar M

2014-01-01

The tau protein is an attractive target for therapy and diagnosis. We started a tau immunotherapy program about 13 years ago and have since demonstrated that active and passive immunotherapies diminish tau pathology and improve function, including cognition, in different mouse models. These findings have been confirmed and extended by several groups. We routinely detect neuronal, and to a lesser extent microglial, antibody uptake correlating with tau pathology. Antibodies bind tau aggregates in the endosomal/lysosomal system, enhancing clearance presumably by promoting their disassembly. Extracellular clearance has recently been shown by others, using antibodies that apparently are not internalized. As most pathological tau is neuronal, intracellular targeting may be more efficacious. However, extracellular tau may be more accessible to antibodies, with tau-antibody complexes a target for microglial phagocytosis. The extent of involvement of each pathway may depend on numerous factors including antibody properties, degree of pathology, and experimental model. On the imaging front, multiple tau ligands derived from β-sheet dyes have been developed by several groups, some with promising results in clinical PET tests. Postmortem analysis should clarify their tau specificity, as in theory and based on histological staining, those are likely to have some affinity for various amyloids. We are developing antibody-derived tau probes that should be more specific, and have in mouse models shown in vivo detection and binding to pathological tau after peripheral injection. These are exciting times for research on tau therapies and diagnostic agents that hopefully can be applied to humans in the near future.

BAG3 facilitates the clearance of endogenous tau in primary neurons.

PubMed

Lei, Zhinian; Brizzee, Corey; Johnson, Gail V W

2015-01-01

Tau is a microtubule associated protein that is found primarily in neurons, and in pathologic conditions, such as Alzheimer's disease (AD) it accumulates and contributes to the disease process. Because tau plays a fundamental role in the pathogenesis of AD and other tauopathies, and in AD mouse models reducing tau levels improves outcomes, approaches that facilitate tau clearance are being considered as therapeutic strategies. However, fundamental to the development of such interventions is a clearer understanding of the mechanisms that regulate tau clearance. Here, we report a novel mechanism of tau degradation mediated by the co-chaperone BAG3. BAG3 has been shown to be an essential component of a complex that targets substrates to the autophagy pathway for degradation. In rat primary neurons, activation of autophagy by inhibition of proteasome activity or treatment with trehalose resulted in significant decreases in tau and phospho-tau levels. These treatments also induced an upregulation of BAG3. Proteasome inhibition activated JNK, which was responsible for the upregulation of BAG3 and increased tau clearance. Inhibiting JNK or knocking down BAG3 blocked the proteasome inhibition-induced decreases in tau. Further, BAG3 overexpression alone resulted in significant decreases in tau and phospho-tau levels in neurons. These results indicate that BAG3 plays a critical role in regulating the levels of tau in neurons, and interventions that increase BAG3 levels could provide a therapeutic approach in the treatment of AD. Copyright © 2015 Elsevier Inc. All rights reserved.

Neutrinos: Nature's Ghosts?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lincoln, Don

2013-06-18

Dr. Don Lincoln introduces one of the most fascinating inhabitants of the subatomic realm: the neutrino. Neutrinos are ghosts of the microworld, almost not interacting at all. In this video, he describes some of their properties and how they were discovered. Studies of neutrinos are expected to be performed at many laboratories across the world and to form one of the cornerstones of the Fermilab research program for the next decade or more.

Neutrinos: Nature's Ghosts?

ScienceCinema

Lincoln, Don

2018-06-07

Dr. Don Lincoln introduces one of the most fascinating inhabitants of the subatomic realm: the neutrino. Neutrinos are ghosts of the microworld, almost not interacting at all. In this video, he describes some of their properties and how they were discovered. Studies of neutrinos are expected to be performed at many laboratories across the world and to form one of the cornerstones of the Fermilab research program for the next decade or more.

Status and Aims of the DUMAND Neutrino Project: the Ocean as a Neutrino Detector

DOE R&D Accomplishments Database

Roberts, A.; Blood, H.; Learned, J.; Reines, F.

1976-07-01

The possibility of using the ocean as a neutrino detector is considered. Neutrino-produced interactions result in charged particles that generate Cherenkov radiation in the water, which can be detected by light-gathering equipment and photomultipliers. The properties of the ocean as seen from this standpoint are critically examined, and the advantages and disadvantages pointed out. Possible uses for such a neutrino detector include (1) the detection of neutrinos emitted in gravitational collapse of stars (supernova production), not only in our own galaxy, but in other galaxies up to perhaps twenty-million light-years away, (2) the extension of high-energy neutrino physics, as currently practiced up to 200 GeV at high-energy accelerators, to energies up to 50 times higher, using neutrinos generated in the atmosphere by cosmic rays, and (3) the possible detection of neutrinos produced by cosmic-ray interactions outside the earth`s atmosphere. The technology for such an undertaking seems to be within reach.

Phosphorylation of Threonine 175 Tau in the Induction of Tau Pathology in Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder (ALS-FTSD). A Review.

PubMed

Moszczynski, Alexander J; Hintermayer, Matthew A; Strong, Michael J

2018-01-01

Approximately 50-60% of all patients with amyotrophic lateral sclerosis (ALS) will develop a deficit of frontotemporal function, ranging from frontotemporal dementia (FTD) to one or more deficits of neuropsychological, speech or language function which are collectively known as the frontotemporal spectrum disorders of ALS (ALS-FTSD). While the neuropathology underlying these disorders is most consistent with a widespread alteration in the metabolism of transactive response DNA-binding protein 43 (TDP-43), in both ALS with cognitive impairment (ALSci) and ALS with FTD (ALS-FTD; also known as MND-FTD) there is evidence for alterations in the metabolism of the microtubule associated protein tau. This alteration in tau metabolism is characterized by pathological phosphorylation at residue Thr 175 (pThr 175 tau) which in vitro is associated with activation of GSK3β (pTyr 216 GSK3β), phosphorylation of Thr 231 tau, and the formation of cytoplasmic inclusions with increased rates of cell death. This putative pathway of pThr 175 induction of pThr 231 and the formation of pathogenic tau inclusions has been recently shown to span a broad range of tauopathies, including chronic traumatic encephalopathy (CTE) and CTE in association with ALS (CTE-ALS). This pathway can be experimentally triggered through a moderate traumatic brain injury, suggesting that it is a primary neuropathological event and not secondary to a more widespread neuronal dysfunction. In this review, we discuss the neuropathological underpinnings of the postulate that ALS is associated with a tauopathy which manifests as a FTSD, and examine possible mechanisms by which phosphorylation at Thr 175 tau is induced. We hypothesize that this might lead to an unfolding of the hairpin structure of tau, activation of GSK3β and pathological tau fibril formation through the induction of cis -Thr 231 tau conformers. A potential role of TDP-43 acting synergistically with pathological tau metabolism is proposed.

Effects of a neutrino-dark energy coupling on oscillations of high-energy neutrinos

NASA Astrophysics Data System (ADS)

Klop, Niki; Ando, Shin'ichiro

2018-03-01

If dark energy (DE) is a dynamical field rather than a cosmological constant, an interaction between DE and the neutrino sector could exist, modifying the neutrino oscillation phenomenology and causing C P and apparent Lorentz violating effects. The terms in the Hamiltonian for flavor propagation induced by the DE-neutrino coupling do not depend on the neutrino energy, while the ordinary components decrease as Δ m2/Eν. Therefore, the DE-induced effects are absent at lower neutrino energies, but become significant at higher energies, allowing to be searched for by neutrino observatories. We explore the impact of the DE-neutrino coupling on the oscillation probability and the flavor transition in the three-flavor framework, and investigate the C P -violating and apparent Lorentz violating effects. We find that DE-induced effects become observable for Eνmeff˜10-20 GeV2, where meff is the effective mass parameter in the DE-induced oscillation probability, and C P is violated over a wide energy range. We also show that current and future experiments have the sensitivity to detect anomalous effects induced by a DE-neutrino coupling and probe the new mixing parameters. The DE-induced effects on neutrino oscillation can be distinguished from other new physics possibilities with similar effects, through the detection of the directional dependence of the interaction, which is specific to this interaction with DE. However, current experiments will not yet be able to measure the small changes of ˜0.03 % in the flavor composition due to this directional effect.

The ELISA-measured increase in cerebrospinal fluid tau that discriminates Alzheimer's disease from other neurodegenerative disorders is not attributable to differential recognition of tau assembly forms.

PubMed

O'Dowd, Seán T; Ardah, Mustafa T; Johansson, Per; Lomakin, Aleksey; Benedek, George B; Roberts, Kinley A; Cummins, Gemma; El Agnaf, Omar M; Svensson, Johan; Zetterberg, Henrik; Lynch, Timothy; Walsh, Dominic M

2013-01-01

Elevated cerebrospinal fluid concentrations of tau discriminate Alzheimer's disease from other neurodegenerative conditions. The reasons for this are unclear. While commercial assay kits are widely used to determine total-tau concentrations, little is known about their ability to detect different aggregation states of tau. We demonstrate that the leading commercial enzyme-linked immunosorbent assay reliably detects aggregated and monomeric tau and evinces good recovery of both species when added into cerebrospinal fluid. Hence, the disparity between total-tau levels encountered in Alzheimer's disease and other neurodegenerative conditions is not due to differential recognition of tau assembly forms or the extent of degeneration.

Solar neutrinos and the MSW effect for three-neutrino mixing

NASA Technical Reports Server (NTRS)

Shi, X.; Schramm, David N.

1991-01-01

Researchers considered three-neutrino Mikheyev-Smirnov-Wolfenstein (MSW) mixing, assuming m sub 3 is much greater than m sub 2 is greater than m sub 1 as expected from theoretical consideration if neutrinos have mass. They calculated the corresponding mixing parameter space allowed by the Cl-37 and Kamiokande 2 experiments. They also calculated the expected depletion for the Ga-71 experiment. They explored a range of theoretical uncertainty due to possible astrophysical effects by varying the B-8 neutrino flux and redoing the MSW mixing calculation.

UX Tau A

NASA Technical Reports Server (NTRS)

2007-01-01

This is an artist's rendition of the one-million-year-old star system called UX Tau A, located approximately 450 light-years away. Observations from NASA's Spitzer Space Telescope showed a gap in the dusty planet-forming disk swirling around the system's central sun-like star.

Spitzer saw a gap in UX Tau A's disk that extends from 0.2 to 56 astronomical units (an astronomical unit is the distance between the sun and Earth). The gap extends from the equivalent of Mercury to Pluto in our solar system, and is sandwiched between thick inner and outer disks on either side. Astronomers suspect that the gap was carved out by one or more forming planets.

Such dusty disks are where planets are thought to be born. Dust grains clump together like snowballs to form larger rocks, and then the bigger rocks collide to form the cores of planets. When rocks revolve around their central star, they act like cosmic vacuum cleaners, picking up all the gas and dust in their path and creating gaps.

Although gaps have been detected in disks swirling around young stars before, UX Tau A is special because the gap is sandwiched between two thick disks of dust. An inner thick dusty disk hugs the central star, then, moving outward, there is a gap, followed by another thick doughnut-shaped disk. Other systems with gaps contain very little to no dust near the central star. In other words, those gaps are more like big holes in the centers of disks.

Some scientists suspect that these holes could have been carved out by a process called photoevaporation. Photoevaporation occurs when radiation from the central star heats up the gas and dust around it to the point where it evaporates away. The fact that there is thick disk swirling extremely close to UX Tau A's central star rules out the photoevaporation scenario. If photoevaporation from the star played a role, then large amounts of dust would not be floating so close to the star.

Interplay of pathogenic forms of human tau with different autophagic pathways.

PubMed

Caballero, Benjamin; Wang, Yipeng; Diaz, Antonio; Tasset, Inmaculada; Juste, Yves Robert; Stiller, Barbara; Mandelkow, Eva-Maria; Mandelkow, Eckhard; Cuervo, Ana Maria

2018-02-01

Loss of neuronal proteostasis, a common feature of the aging brain, is accelerated in neurodegenerative disorders, including different types of tauopathies. Aberrant turnover of tau, a microtubule-stabilizing protein, contributes to its accumulation and subsequent toxicity in tauopathy patients' brains. A direct toxic effect of pathogenic forms of tau on the proteolytic systems that normally contribute to their turnover has been proposed. In this study, we analyzed the contribution of three different types of autophagy, macroautophagy, chaperone-mediated autophagy, and endosomal microautophagy to the degradation of tau protein variants and tau mutations associated with this age-related disease. We have found that the pathogenic P301L mutation inhibits degradation of tau by any of the three autophagic pathways, whereas the risk-associated tau mutation A152T reroutes tau for degradation through a different autophagy pathway. We also found defective autophagic degradation of tau when using mutations that mimic common posttranslational modifications in tau or known to promote its aggregation. Interestingly, although most mutations markedly reduced degradation of tau through autophagy, the step of this process preferentially affected varies depending on the type of tau mutation. Overall, our studies unveil a complex interplay between the multiple modifications of tau and selective forms of autophagy that may determine its physiological degradation and its faulty clearance in the disease context. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy

PubMed Central

Kanaan, Nicholas M.; Cox, Kristine; Alvarez, Victor E.; Stein, Thor D.; Poncil, Sharra; McKee, Ann C.

2016-01-01

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that develops after repetitive head injury. Several lines of evidence in other tauopathies suggest that tau oligomer formation induces neurotoxicity and that tau oligomer-mediated neurotoxicity involves induction of axonal dysfunction through exposure of an N-terminal motif in tau, the phosphatase-activating domain (PAD). Additionally, phosphorylation at serine 422 in tau occurs early and correlates with cognitive decline in patients with Alzheimer disease (AD). We performed immunohistochemistry and immunofluorescence on fixed brain sections and biochemical analysis of fresh brain extracts to characterize the presence of PAD-exposed tau (TNT1 antibody), tau oligomers (TOC1 antibody), tau phosphorylated at S422 (pS422 antibody), and tau truncated at D421 (TauC3 antibody) in the brains of 9-11 cases with CTE and cases of nondemented aged controls and AD (Braak VI) (n = 6, each). All 3 early tau markers (ie, TNT1, TOC1, and pS422) were present in CTE and displayed extensive colocalization in perivascular tau lesions that are considered diagnostic for CTE. Notably, the TauC3 epitope, which is abundant in AD, was relatively sparse in CTE. Together, these results provide the first description of PAD exposure, TOC1 reactive oligomers, phosphorylation of S422, and TauC3 truncation in the tau pathology of CTE. PMID:26671985

Tau Ranging Revisited

NASA Technical Reports Server (NTRS)

Tausworthe, Robert C.

1989-01-01

Report reviews history of tau ranging and advocates use of advanced electronic circuitry to revive this composite-code-uplink spacecraft-ranging technique. Very-large-scale integration gives new life to abandoned distance-measuring technique.

Hsp90 activator Aha1 drives production of pathological tau aggregates

PubMed Central

Shelton, Lindsey B.; Baker, Jeremy D.; Zheng, Dali; Sullivan, Leia E.; Solanki, Parth K.; Webster, Jack M.; Sun, Zheying; Sabbagh, Jonathan J.; Nordhues, Bryce A.; Koren, John; Ghosh, Suman; Blagg, Brian S. J.; Dickey, Chad A.

2017-01-01

The microtubule-associated protein tau (MAPT, tau) forms neurotoxic aggregates that promote cognitive deficits in tauopathies, the most common of which is Alzheimer’s disease (AD). The 90-kDa heat shock protein (Hsp90) chaperone system affects the accumulation of these toxic tau species, which can be modulated with Hsp90 inhibitors. However, many Hsp90 inhibitors are not blood–brain barrier-permeable, and several present associated toxicities. Here, we find that the cochaperone, activator of Hsp90 ATPase homolog 1 (Aha1), dramatically increased the production of aggregated tau. Treatment with an Aha1 inhibitor, KU-177, dramatically reduced the accumulation of insoluble tau. Aha1 colocalized with tau pathology in human brain tissue, and this association positively correlated with AD progression. Aha1 overexpression in the rTg4510 tau transgenic mouse model promoted insoluble and oligomeric tau accumulation leading to a physiological deficit in cognitive function. Overall, these data demonstrate that Aha1 contributes to tau fibril formation and neurotoxicity through Hsp90. This suggests that therapeutics targeting Aha1 may reduce toxic tau oligomers and slow or prevent neurodegenerative disease progression. PMID:28827321

Neutrino mass sum-rule

NASA Astrophysics Data System (ADS)

Damanik, Asan

2018-03-01

Neutrino mass sum-rele is a very important research subject from theoretical side because neutrino oscillation experiment only gave us two squared-mass differences and three mixing angles. We review neutrino mass sum-rule in literature that have been reported by many authors and discuss its phenomenological implications.

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

PubMed Central

Asai, Hirohide; Ikezu, Seiko; Tsunoda, Satoshi; Medalla, Maria; Luebke, Jennifer; Haydar, Tarik; Wolozin, Benjamin; Butovsky, Oleg; Kügler, Sebastian; Ikezu, Tsuneya

2015-01-01

Accumulation of pathological tau protein is a major hallmark of Alzheimer’s disease. Tau protein spreads from the entorhinal cortex to the hippocampal region early in the disease. Microglia, the primary phagocytes in the brain, are positively correlated with tau pathology, but their involvement in tau propagation is unknown. We developed an adeno-associated virus–based model exhibiting rapid tau propagation from the entorhinal cortex to the dentate gyrus in 4 weeks. We found that depleting microglia dramatically suppressed the propagation of tau and reduced excitability in the dentate gyrus in this mouse model. Moreover, we demonstrate that microglia spread tau via exosome secretion, and inhibiting exosome synthesis significantly reduced tau propagation in vitro and in vivo. These data suggest that microglia and exosomes contribute to the progression of tauopathy and that the exosome secretion pathway may be a therapeutic target. PMID:26436904

Longitudinal tau PET in ageing and Alzheimer’s disease

PubMed Central

Jack, Clifford R; Wiste, Heather J; Schwarz, Christopher G; Lowe, Val J; Senjem, Matthew L; Vemuri, Prashanthi; Weigand, Stephen D; Therneau, Terry M; Knopman, Dave S; Gunter, Jeffrey L; Jones, David T; Graff-Radford, Jonathan; Kantarci, Kejal; Roberts, Rosebud O; Mielke, Michelle M; Machulda, Mary M; Petersen, Ronald C

2018-01-01

Abstract See Hansson and Mormino (doi:10.1093/brain/awy065) for a scientific commentary on this article. Our objective was to compare different whole-brain and region-specific measurements of within-person change on serial tau PET and evaluate its utility for clinical trials. We studied 126 individuals: 59 cognitively unimpaired with normal amyloid, 37 cognitively unimpaired with abnormal amyloid, and 30 cognitively impaired with an amnestic phenotype and abnormal amyloid. All had baseline amyloid PET and two tau PET, MRI, and clinical assessments. We compared the topography across all cortical regions of interest of tau PET accumulation rates and the rates of four different whole-brain or region-specific meta-regions of interest among the three clinical groups. We computed sample size estimates for change in tau PET, cortical volume, and memory/mental status indices for use as outcome measures in clinical trials. The cognitively unimpaired normal amyloid group had no observable tau accumulation throughout the brain. Tau accumulation rates in cognitively unimpaired abnormal amyloid were low [0.006 standardized uptake value ratio (SUVR), 0.5%, per year] but greater than rates in the cognitively unimpaired normal amyloid group in the basal and mid-temporal, retrosplenial, posterior cingulate, and entorhinal regions of interest. Thus, the earliest elevation in accumulation rates was widespread and not confined to the entorhinal cortex. Tau accumulation rates in the cognitively impaired abnormal amyloid group were 0.053 SUVR (3%) per year and greater than rates in cognitively unimpaired abnormal amyloid in all cortical areas except medial temporal. Rates of accumulation in the four meta-regions of interest differed but only slightly from one another. Among all tau PET meta-regions of interest, sample size estimates were smallest for a temporal lobe composite within cognitively unimpaired abnormal amyloid and for the late Alzheimer’s disease meta-region of interest

Structure-activity relationship of cyanine tau aggregation inhibitors

PubMed Central

Chang, Edward; Congdon, Erin E.; Honson, Nicolette S.; Duff, Karen E.; Kuret, Jeff

2009-01-01

A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine bridge length, and the nature of meso- and N-substituents. One potent member of the series, 3,3’-diethyl-9-methylthiacarbocyanine iodide (compound 11), retained submicromolar potency and had calculated physical properties consistent with blood-brain barrier and cell membrane penetration. Exposure of organotypic slices prepared from JNPL3 transgenic mice (which express human tau harboring the aggregation prone P301L tauopathy mutation) to compound 11 for one week revealed a biphasic dose response relationship. Low nanomolar concentrations decreased insoluble tau aggregates to half those observed in slices treated with vehicle alone. In contrast, high concentrations (≥300 nM) augmented tau aggregation and produced abnormalities in tissue tubulin levels. These data suggest that certain symmetrical carbocyanine dyes can modulate tau aggregation in the slice biological model at concentrations well below those associated with toxicity. PMID:19432420

Neutrino nuclear responses for double beta decays and astro neutrinos by charge exchange reactions

NASA Astrophysics Data System (ADS)

Ejiri, Hiroyasu

2014-09-01

Neutrino nuclear responses are crucial for neutrino studies in nuclei. Charge exchange reactions (CER) are shown to be used to study charged current neutrino nuclear responses associated with double beta decays(DBD)and astro neutrino interactions. CERs to be used are high energy-resolution (He3 ,t) reactions at RCNP, photonuclear reactions via IAR at NewSUBARU and muon capture reactions at MUSIC RCNP and MLF J-PARC. The Gamow Teller (GT) strengths studied by CERs reproduce the observed 2 neutrino DBD matrix elements. The GT and spin dipole (SD) matrix elements are found to be reduced much due to the nucleon spin isospin correlations and the non-nucleonic (delta isobar) nuclear medium effects. Impacts of the reductions on the DBD matrix elements and astro neutrino interactions are discussed.

Nonstandard neutrino interactions in supernovae

NASA Astrophysics Data System (ADS)

Stapleford, Charles J.; Väänänen, Daavid J.; Kneller, James P.; McLaughlin, Gail C.; Shapiro, Brandon T.

2016-11-01

Nonstandard interactions (NSI) of neutrinos with matter can significantly alter neutrino flavor evolution in supernovae with the potential to impact explosion dynamics, nucleosynthesis, and the neutrinos signal. In this paper, we explore, both numerically and analytically, the landscape of neutrino flavor transformation effects in supernovae due to NSI and find a new, heretofore unseen transformation processes can occur. These new transformations can take place with NSI strengths well below current experimental limits. Within a broad swath of NSI parameter space, we observe symmetric and standard matter-neutrino resonances for supernovae neutrinos, a transformation effect previously only seen in compact object merger scenarios; in another region of the parameter space we find the NSI can induce neutrino collective effects in scenarios where none would appear with only the standard case of neutrino oscillation physics; and in a third region the NSI can lead to the disappearance of the high density Mikheyev-Smirnov-Wolfenstein resonance. Using a variety of analytical tools, we are able to describe quantitatively the numerical results allowing us to partition the NSI parameter according to the transformation processes observed. Our results indicate nonstandard interactions of supernova neutrinos provide a sensitive probe of beyond the Standard Model physics complementary to present and future terrestrial experiments.

APP metabolism regulates tau proteostasis in human cerebral cortex neurons.

PubMed

Moore, Steven; Evans, Lewis D B; Andersson, Therese; Portelius, Erik; Smith, James; Dias, Tatyana B; Saurat, Nathalie; McGlade, Amelia; Kirwan, Peter; Blennow, Kaj; Hardy, John; Zetterberg, Henrik; Livesey, Frederick J

2015-05-05

Accumulation of Aβ peptide fragments of the APP protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of Alzheimer's disease (AD). To investigate the relationship between APP metabolism and tau protein levels and phosphorylation, we studied human-stem-cell-derived forebrain neurons with genetic forms of AD, all of which increase the release of pathogenic Aβ peptides. We identified marked increases in intracellular tau in genetic forms of AD that either mutated APP or increased its dosage, suggesting that APP metabolism is coupled to changes in tau proteostasis. Manipulating APP metabolism by β-secretase and γ-secretase inhibition, as well as γ-secretase modulation, results in specific increases and decreases in tau protein levels. These data demonstrate that APP metabolism regulates tau proteostasis and suggest that the relationship between APP processing and tau is not mediated solely through extracellular Aβ signaling to neurons. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet.

PubMed

Gratuze, Maud; Julien, Jacinthe; Morin, Françoise; Marette, André; Planel, Emmanuel

2017-10-03

Tau is a microtubule-associated protein that becomes pathological when it undergoes hyperphosphorylation and aggregation as seen in Alzheimer's disease (AD). AD is mostly sporadic, with environmental, biological and/or genetic risks factors, interacting together to promote the disease. In the past decade, reports have suggested that obesity in midlife could be one of these risk factors. On the other hand, caloric restriction and physical exercise have been reported to reduce the incidence and outcome of obesity as well as AD. We evaluated the impact of voluntary physical exercise and caloric restriction on tau pathology during 2months in hTau mice under high caloric diet in order to evaluate if these strategies could prevent AD-like pathology in obese conditions. We found no effects of obesity induced by Western diet on both Tau phosphorylation and aggregation compared to controls. However, exercise reduced tau phosphorylation while caloric restriction exacerbated its aggregation in the brains of obese hTau mice. We then examined the mechanisms underlying changes in tau phosphorylation and aggregation by exploring major tau kinases and phosphatases and key proteins involved in autophagy. However, there were no significant effects of voluntary exercise and caloric restriction on these proteins in hTau mice that could explain our results. In this study, we report differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in our obese mice, namely beneficial effect of exercise on tau phosphorylation and deleterious effect of caloric restriction on tau aggregation. Our results suggest that lifestyle strategies used to reduce metabolic disorders and AD must be selected and studied carefully to avoid exacerbation of pathologies. Copyright © 2017. Published by Elsevier Inc.

Neutrino oscillations refitted

NASA Astrophysics Data System (ADS)

Forero, D. V.; Tórtola, M.; Valle, J. W. F.

2014-11-01

Here, we update our previous global fit of neutrino oscillations by including the recent results that have appeared since the Neutrino 2012 conference. These include the measurements of reactor antineutrino disappearance reported by Daya Bay and RENO, together with latest T2K and MINOS data including both disappearance and appearance channels. We also include the revised results from the third solar phase of Super-Kamiokande, SK-III, as well as new solar results from the fourth phase of Super-Kamiokande, SK-IV. We find that the preferred global determination of the atmospheric angle θ23 is consistent with maximal mixing. We also determine the impact of the new data upon all the other neutrino oscillation parameters with an emphasis on the increasing sensitivity to the C P phase, thanks to the interplay between accelerator and reactor data. In the Appendix, we present the updated results obtained after the inclusion of new reactor data presented at the Neutrino 2014 conference. We discuss their impact on the global neutrino analysis.

Higgs Production Through Sterile Neutrinos

NASA Astrophysics Data System (ADS)

Antusch, Stefan; Cazzato, Eros; Fischer, Oliver

In scenarios with sterile (right-handed) neutrinos with an approximate "lepton-numberlike" symmetry, the heavy neutrinos (the mass eigenstates) can have masses around the electroweak scale and couple to the Higgs boson with, in principle, unsuppressed Yukawa couplings, while the smallness of the light neutrinos' masses is guaranteed by the approximate symmetry. The on-shell production of the heavy neutrinos at lepton colliders, together with their subsequent decays into a light neutrino and a Higgs boson, constitutes a resonant contribution to the Higgs production mechanism. This resonant mono-Higgs production mechanism can contribute significantly to the mono-Higgs observables at future lepton colliders. A dedicated search for the heavy neutrinos in this channel exhibits sensitivities for the electron neutrino Yukawa coupling as small as ˜ 5 × 10-3. Furthermore, the sensitivity is enhanced for higher center-of-mass energies, when identical integrated luminosities are considered.

Impact of Neutrino Flavor Oscillations on the Neutrino-driven Wind Nucleosynthesis of an Electron-capture Supernova

NASA Astrophysics Data System (ADS)

Pllumbi, Else; Tamborra, Irene; Wanajo, Shinya; Janka, Hans-Thomas; Hüdepohl, Lorenz

2015-08-01

Neutrino oscillations, especially to light sterile states, can affect nucleosynthesis yields because of their possible feedback effect on the electron fraction (Ye). For the first time, we perform nucleosynthesis calculations for neutrino-driven wind trajectories from the neutrino-cooling phase of an 8.8 {M}⊙ electron-capture supernova (SN), whose hydrodynamic evolution was computed in spherical symmetry with sophisticated neutrino transport and whose Ye evolution was post-processed by including neutrino oscillations between both active and active-sterile flavors. We also take into account the α-effect as well as weak magnetism and recoil corrections in the neutrino absorption and emission processes. We observe effects on the Ye evolution that depend in a subtle way on the relative radial positions of the sterile Mikheyev-Smirnov-Wolfenstein resonances, on collective flavor transformations, and on the formation of α particles. For the adopted SN progenitor, we find that neutrino oscillations, also to a sterile state with eV mass, do not significantly affect the element formation and in particular cannot make the post-explosion wind outflow neutron-rich enough to activate a strong r-process. Our conclusions become even more robust when, in order to mimic equation-of-state-dependent corrections due to nucleon potential effects in the dense-medium neutrino opacities, six cases with reduced Ye in the wind are considered. In these cases, despite the conversion of active neutrinos to sterile neutrinos, Ye increases or is not significantly lowered compared to the values obtained without oscillations and active flavor transformations. This is a consequence of a complicated interplay between sterile-neutrino production, neutrino-neutrino interactions, and α-effect.

Dimethyl Sulfoxide Induces Both Direct and Indirect Tau Hyperphosphorylation

PubMed Central

Julien, Carl; Marcouiller, François; Bretteville, Alexis; El Khoury, Noura B.; Baillargeon, Joanie; Hébert, Sébastien S.; Planel, Emmanuel

2012-01-01

Dimethyl sulfoxide (DMSO) is widely used as a solvent or vehicle for biological studies, and for treatment of specific disorders, including traumatic brain injury and several forms of amyloidosis. As Alzheimer’s disease (AD) brains are characterized by deposits of β-amyloid peptides, it has been suggested that DMSO could be used as a treatment for this devastating disease. AD brains are also characterized by aggregates of hyperphosphorylated tau protein, but the effect of DMSO on tau phosphorylation is unknown. We thus investigated the impact of DMSO on tau phosphorylation in vitro and in vivo. One hour following intraperitoneal administration of 1 or 2 ml/kg DMSO in mice, no change was observed in tau phosphorylation. However, at 4 ml/kg, tau was hyperphosphorylated at AT8 (Ser202/Thr205), PHF-1 (Ser396/Ser404) and AT180 (Thr231) epitopes. At this dose, we also noticed that the animals were hypothermic. When the mice were maintained normothermic, the effect of 4 ml/kg DMSO on tau hyperphosphorylation was prevented. On the other hand, in SH-SY5Y cells, 0.1% DMSO induced tau hyperphosphorylation at AT8 and AT180 phosphoepitopes in normothermic conditions. Globally, these findings demonstrate that DMSO can induce tau hyperphosphorylation indirectly via hypothermia in vivo, and directly in vitro. These data should caution researchers working with DMSO as it can induce artifactual results both in vivo and in vitro. PMID:22768202

Tau Oligomers as Pathogenic Seeds: Preparation and Propagation In Vitro and In Vivo.

PubMed

Gerson, Julia E; Sengupta, Urmi; Kayed, Rakez

2017-01-01

Tau oligomers have been shown to be the main toxic tau species in a number of neurodegenerative disorders. In order to study tau oligomers both in vitro and in vivo, we have established methods for the reliable preparation, isolation, and detection of tau oligomers. Methods for the seeding of tau oligomers, isolation of tau oligomers from tissue, and detection of tau oligomers using tau oligomer-specific antibodies by biochemical and immunohistochemical methods are detailed below.

Raymond Davis Jr., Solar Neutrinos, and the Solar Neutrino Problems

Science.gov Websites

Neutrinos. II. Experimental; DOE Technical Report, March 16, 1964 Search for Neutrinos from the Sun; DOE Raymond Davis Dies, BNL Newsroom, June 1, 2006 Top Some links on this page may take you to non-federal

Molecular mechanism of tau aggregation induced by anionic and cationic dyes.

PubMed

Lira-De León, Karla I; García-Gutiérrez, Ponciano; Serratos, Iris N; Palomera-Cárdenas, Marianela; Figueroa-Corona, María Del P; Campos-Peña, Victoria; Meraz-Ríos, Marco A

2013-01-01

Abnormal tau filaments are a hallmark of Alzheimer's disease. Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in vitro. SH-SY5Y cells were incubated with each dye for seven days leading to intracellular aggregates of tau protein, with different morphological characteristics. Interestingly, these tau aggregates were not observed when the Methylene Blue dye was added to the cell culture. In order to investigate the molecular mechanisms underlying this phenomenon, we developed a computational model for the interaction of the tau paired helical filament (PHF) core with every dye by docking analysis. The polar/electrostatic and nonpolar contribution to the free binding energy in the tau PHF core-anionic dye interaction was determined. We found that the tau PHF core can generate a positive net charge within the binding site localized at residuesLys311 and Lys340 (numbering according to the longest isoform hTau40). These residues are important for the binding affinity of the negative charges present in the anionic dyes causing an electrostatic environment that stabilizes the complex. Tau PHF core protofibril-Congo Red interaction has a stronger binding affinity compared to Thiazine Red or Thioflavin S. By contrast, the cationic dye Methylene Blue does not bind to nor stabilize the tau PHF core protofibrils. These results characterize the driving forces responsible for the binding of tau to anionic dyes leading to their self-aggregation and suggest that Methylene Blue may act as a destabilizing agent of tau aggregates.

The Sudbury Neutrino Observatory

DOE PAGES

Bellerive, Alain; Klein, J. R.; McDonald, A. B.; ...

2016-04-27

This review paper provides a summary of the published results of the Sudbury Neutrino Observatory (SNO) experiment that was carried out by an international scientific collaboration with data collected during the period from 1999 to 2006. By using heavy water as a detection medium, the SNO experiment demonstrated clearly that solar electron neutrinos from 8B decay in the solar core change into other active neutrino flavors in transit to Earth. The reaction on deuterium that has equal sensitivity to all active neutrino flavors also provides a very accurate measure of the initial solar flux for comparison with solar models. Thismore » review summarizes the results from three phases of solar neutrino detection as well as other physics results obtained from analyses of the SNO data.« less

Neutrino Oscillations: Eighty Years in Review

NASA Astrophysics Data System (ADS)

Bowers, Rebecca Lyn

In order to discuss neutrino oscillations, it is necessary to have knowledge of the developments in the field spanning the last eighty years. The existence of the neutrino was posited by Wolfgang Pauli in 1930 to account for the mass defect in beta decay, and to this day physicists are still endeavoring to answer fundamental questions about this enigmatic particle. The scope of this thesis includes a historical background of neutrino physics and a discussion of neutrinos and the Standard Model; subsequent to this is a discussion of the Solar Neutrino Problem, which provided the impetus for the proposal of neutrino oscillations. Bolstering the theory of neutrino oscillations (which is developed in the body of this thesis) are neutrino detector experiments and their results; these include the Homestake experiment, SNO, Kamiokande and Super-Kamiokande, MINOS, and Double-Chooz. We also include relevant derivations, most particularly of the quantum mechanics of neutrino oscillations as treated in the wave packet formalism. We have amassed here the principle theories and experimental results -- a mere tip of the iceberg -- that have brought us to our current understanding of neutrino oscillations. We have also studied the quantum mechanics of neutrino oscillations and developed for ourselves the wave packet formalism describing the phenomenon.

Wess-Zumino current and the structure of the decay tau- -->K- pi- K+ nu tau.

PubMed

Coan, T E; Gao, Y S; Liu, F; Stroynowski, R; Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dambasuren, E; Dorjkhaidav, O; Haynes, J; Menaa, N; Mountain, R; Muramatsu, H; Nandakumar, R; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, Kevin; Mahmood, A H; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Bornheim, A; Lipeles, E; Pappas, S P; Shapiro, A; Weinstein, A J; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Boisvert, V; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Galik, R S; Gibbons, L; Gittelman, B; Gray, S W; Hartill, D L; Heltsley, B K; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Magerkurth, A; Mahlke-Krüger, H; Meyer, T O; Patterson, J R; Pedlar, T K; Peterson, D; Pivarski, J; Riley, D; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Sun, W M; Thayer, J G; Urner, D; Wilksen, T; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Potlia, V; Stoeck, H; Yelton, J; Eisenstein, B I; Gollin, G D; Karliner, I; Lowrey, N; Naik, P; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Edwards, K W; Besson, D; Gao, K Y; Gong, D T; Kubota, Y; Li, S Z; Poling, R; Scott, A W; Smith, A; Stepaniak, C J; Urheim, J; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Arms, K; Eckhart, E; Gan, K K; Gwon, C; Severini, H; Skubic, P; Asner, D M; Dytman, S A; Mehrabyan, S; Mueller, J A; Nam, S; Savinov, V; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shibata, E I; Shipsey, I P J; Adams, G S; Chasse, M; Cummings, J P; Danko, I; Napolitano, J; Cronin-Hennessy, D; Park, C S; Park, W; Thayer, J B; Thorndike, E H

2004-06-11

We present the first study of the vector (Wess-Zumino) current in tau(-)-->K-pi-K+nu(tau) decay using data collected with the CLEO III detector at the Cornell Electron Storage Ring. We determine the quantitative contributions to the decay width from the vector and axial vector currents. Within the framework of a model by Kühn and Mirkes, we identify the quantitative contributions to the total decay rate from the intermediate states omegapi, rho(')pi, and K*K.

Supernova neutrino detection in LZ

NASA Astrophysics Data System (ADS)

Khaitan, D.

2018-02-01

In the first 10 seconds of a core-collapse supernova, almost all of its progenitor's gravitational potential, O(1053 ergs), is carried away in the form of neutrinos. These neutrinos, with O(10 MeV) kinetic energy, can interact via coherent elastic neutrino-nucleus scattering (CEνNS) depositing O(1 keV) in detectors. In this work we describe the performances of low-background dark matter detectors, such as LUX-ZEPLIN (LZ), optimized for detecting low-energy depositions, in detecting these neutrino interactions. For instance, a 27 Msolar supernova at 10 kpc is expected to produce ~350 neutrino interactions in the 7-tonne liquid xenon active volume of LZ. Based on the LS220 EoS neutrino flux model for a SN, the Noble Element Simulation Technique (NEST), and predicted CEνNS cross-sections for xenon, to study energy deposition and detection of SN neutrinos in LZ. We simulate the response of the LZ data acquisition system (DAQ) and demonstrate its capability and limitations in handling this interaction rate. We present an overview of the LZ detector, focusing on the benefits of liquid xenon for supernova neutrino detection. We discuss energy deposition and detector response simulations and their results. We present an analysis technique to reconstruct the total number of neutrinos and the time of the supernova core bounce.

Supernova neutrinos and explosive nucleosynthesis

NASA Astrophysics Data System (ADS)

Kajino, T.; Aoki, W.; Cheoun, M.-K.; Hayakawa, T.; Hidaka, J.; Hirai, Y.; Mathews, G. J.; Nakamura, K.; Shibagaki, S.; Suzuki, T.

2014-05-01

Core-collapse supernovae eject huge amount of flux of energetic neutrinos. We studied the explosive nucleosyn-thesis in supernovae and found that several isotopes 7Li, 11B, 92Nb, 138La and 180Ta as well as r-process nuclei are affected by the neutrino interactions. The abundance of these isotopes therefore depends strongly on the neutrino flavor oscillation due to the Mikheyev-Smirnov-Wolfenstein (MSW) effect. We discuss first how to determine the neutrino temperatures in order to explain the observed solar system abundances of these isotopes, combined with Galactic chemical evolution of the light nuclei and the heavy r-process elements. We then study the effects of neutrino oscillation on their abundances, and propose a novel method to determine the still unknown neutrino oscillation parameters, mass hierarchy and θ13, simultaneously. There is recent evidence that SiC X grains from the Murchison meteorite may contain supernova-produced light elements 11B and 7Li encapsulated in the presolar grains. Combining the recent experimental constraints on θ13, we show that our method sug-gests at a marginal preference for an inverted neutrino mass hierarchy. Finally, we discuss supernova relic neutrinos that may indicate the softness of the equation of state (EoS) of nuclear matter as well as adiabatic conditions of the neutrino oscillation.

Inhibition of GSK3 dependent tau phosphorylation by metals.

PubMed

Gómez-Ramos, Alberto; Domínguez, Jorge; Zafra, Delia; Corominola, Helena; Gomis, Ramon; Guinovart, Joan J; Avila, Jesús

2006-04-01

One of the main pathological characteristics of Alzheimer's disease is the presence in the brain of the patients of an aberrant structure, the paired helical filaments, composed of hyperphosphorylated tau. The level of tau phosphorylation has been correlated with the capacity for tau aggregation. Thus, the mechanism for tau phosphorylation could be important to clarify those pathological features in Alzheimer's disease. Tau protein could be modified by different kinases, being GSK3 the one that could modify more sites of that protein. GSK3 activity could be modulate by the presence of metals like magnesium that can be required for the proper function of the kinase, whereas, metals like manganesum or lithium inhibit the activity of the kinase. Many works have been done to study the inhibition of GSK3 by lithium, a specific inhibitor of that kinase. More recently, it has been indicated that sodium tungstate could also inhibit GSK3 through a different mechanism. In this review, we discuss the effect of these two metals, lithium and tungstate, on GSK3 (or tau I kinase) activity.

Neutrino parameters from reactor and accelerator neutrino experiments

NASA Astrophysics Data System (ADS)

Lindner, Manfred; Rodejohann, Werner; Xu, Xun-Jie

2018-04-01

We revisit correlations of neutrino oscillation parameters in reactor and long-baseline neutrino oscillation experiments. A framework based on an effective value of θ13 is presented, which can be used to analytically study the correlations and explain some questions including why and when δC P has the best fit value of -π /2 , why current and future long-baseline experiments will have less precision of δC P around ±π /2 than that around zero, etc. Recent hints on the C P phase are then considered from the point of view that different reactor and long-baseline neutrino experiments provide currently different best-fit values of θ13 and θ23. We point out that the significance of the hints changes for the different available best-fit values.

Rapid Neurofibrillary Tangle Formation after Localized Gene Transfer of Mutated Tau

PubMed Central

Klein, Ronald L.; Lin, Wen-Lang; Dickson, Dennis W.; Lewis, Jada; Hutton, Michael; Duff, Karen; Meyer, Edwin M.; King, Michael A.

2004-01-01

Neurofibrillary pathology was produced in the brains of adult rats after localized gene transfer of human tau carrying the P301L mutation, which is associated with frontotemporal dementia with parkinsonism. Within 1 month of in situ transfection of the basal forebrain region of normal rats, tau-immunoreactive and argyrophilic neuronal lesions formed. The fibrillar lesions had features of neurofibrillary tangles and tau immunoreactivity at light and electron microscopic levels. In addition to neurofibrillary tangles, other tau pathology, including pretangles and neuropil threads, was abundant and widespread. Tau gene transfer to the hippocampal region of amyloid-depositing transgenic mice produced pretangles and threads, as well as intensely tau-immunoreactive neurites in amyloid plaques. The ability to produce neurofibrillary pathology in adult rodents makes this a useful method to study tau-related neurodegeneration. PMID:14695347

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics.

PubMed

Pritchard, Susanne M; Dolan, Philip J; Vitkus, Alisa; Johnson, Gail V W

2011-08-01

It has been almost 25 years since the initial discovery that tau was the primary component of the neurofibrillary tangles (NFTs) in Alzheimer disease (AD) brain. Although AD is defined by both β-amyloid (Aβ) pathology (Aβ plaques) and tau pathology (NFTs), whether or not tau played a critical role in disease pathogenesis was a subject of discussion for many years. However, given the increasing evidence that pathological forms of tau can compromise neuronal function and that tau is likely an important mediator of Aβ toxicity, there is a growing awareness that tau is a central player in AD pathogenesis. In this review we begin with a brief history of tau, then provide an overview of pathological forms of tau, followed by a discussion of the differential degradation of tau by either the proteasome or autophagy and possible mechanisms by which pathological forms of tau may exert their toxicity. We conclude by discussing possible avenues for therapeutic intervention based on these emerging themes of tau's role in AD. © 2011 The Authors Journal compilation © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.

Search for sterile neutrinos in the neutrino-4 experiment

NASA Astrophysics Data System (ADS)

Serebrov, A. P.; Ivochkin, V. G.; Samoilov, R. M.; Fomin, A. K.; Polyushkin, A. O.; Zinov'ev, V. G.; Neustroev, P. V.; Golovtsov, V. L.; Chernyi, A. V.; Zherebtsov, O. M.; Martem'yanov, V. P.; Tarasenkov, V. G.; Aleshin, V. I.; Petelin, A. L.; Izhutov, A. L.; Tuzov, A. A.; Sazontov, S. A.; Ryazanov, D. K.; Gromov, M. O.; Afanas'ev, V. V.; Zaitsev, M. E.; Chaikovskii, M. E.

2017-03-01

An experimental search for sterile neutrinos has been carried out at a neutrino facility based on the SM-3 nuclear reactor in Dimitrovgrad, Russia. The movable detector with passive shielding against the external radiation may be positioned at a distance varying between 6 and 12 m from the center of the reactor. The antineutrino flux has for the first time been measured using a movable detector placed close to the antineutrino source. The accuracy of the measurements is largely restricted by the cosmic background. The results of the measurements performed at small and large distances are analyzed in terms of the sterile-neutrino model parameters Δ m 14 2 and sin22θ14.

Detectability of thermal neutrinos from binary neutron-star mergers and implications for neutrino physics

NASA Astrophysics Data System (ADS)

Kyutoku, Koutarou; Kashiyama, Kazumi

2018-05-01

We propose a long-term strategy for detecting thermal neutrinos from the remnant of binary neutron-star mergers with a future M-ton water-Cherenkov detector such as Hyper-Kamiokande. Monitoring ≳2500 mergers within ≲200 Mpc , we may be able to detect a single neutrino with a human time-scale operation of ≈80 Mtyears for the merger rate of 1 Mpc-3 Myr-1 , which is slightly lower than the median value derived by the LIGO-Virgo Collaboration with GW170817. Although the number of neutrino events is minimal, contamination from other sources of neutrinos can be reduced efficiently to ≈0.03 by analyzing only ≈1 s after each merger identified with gravitational-wave detectors if gadolinium is dissolved in the water. The contamination may be reduced further to ≈0.01 if we allow the increase of waiting time by a factor of ≈1.7 . The detection of even a single neutrino can pin down the energy scale of thermal neutrino emission from binary neutron-star mergers and could strongly support or disfavor formation of remnant massive neutron stars. Because the dispersion relation of gravitational waves is now securely constrained to that of massless particles with a corresponding limit on the graviton mass of ≲10-22 eV /c2 by binary black-hole mergers, the time delay of a neutrino from gravitational waves can be used to put an upper limit of ≲O (10 ) meV /c2 on the absolute neutrino mass in the lightest eigenstate. Large neutrino detectors will enhance the detectability, and, in particular, 5 Mt Deep-TITAND and 10 Mt MICA planned in the future will allow us to detect thermal neutrinos every ≈16 and 8 years, respectively, increasing the significance.

Solar Neutrino Problem

DOE R&D Accomplishments Database

Davis, R. Jr.; Evans, J. C.; Cleveland, B. T.

1978-04-28

A summary of the results of the Brookhaven solar neutrino experiment is given and discussed in relation to solar model calculations. A review is given of the merits of various new solar neutrino detectors that were proposed.

Observation of Electron Neutrino Appearance in a Muon Neutrino Beam

NASA Astrophysics Data System (ADS)

Abe, K.; Adam, J.; Aihara, H.; Akiri, T.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Ariga, T.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bass, M.; Batkiewicz, M.; Bay, F.; Bentham, S. W.; Berardi, V.; Berger, B. E.; Berkman, S.; Bertram, I.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S. R.; Densham, C.; Di Lodovico, F.; Di Luise, S.; Drapier, O.; Duboyski, T.; Duffy, K.; Dufour, F.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Emery, S.; Ereditato, A.; Escudero, L.; Finch, A. J.; Floetotto, L.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Gaudin, A.; Giffin, S.; Giganti, C.; Gilje, K.; Goeldi, D.; Golan, T.; Gomez-Cadenas, J. J.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Ives, S. J.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Johnson, R. A.; Jo, J. H.; Jonsson, P.; Jung, C. K.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Koch, L.; Kolaceke, A.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kreslo, I.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kumaratunga, S.; Kurjata, R.; Kutter, T.; Lagoda, J.; Laihem, K.; Lamont, I.; Laveder, M.; Lawe, M.; Lazos, M.; Lee, K. P.; Licciardi, C.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Ludovici, L.; Macaire, M.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marino, A. D.; Marteau, J.; Martin, J. F.; Maruyama, T.; Marzec, J.; Mathie, E. L.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Mine, S.; Missert, A.; Miura, M.; Monfregola, L.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nagasaki, T.; Nakadaira, T.; Nakahata, M.; Nakai, T.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Naples, D.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Owen, R. A.; Oyama, Y.; Palladino, V.; Paolone, V.; Payne, D.; Pearce, G. F.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pickard, L. J.; Pinzon Guerra, E. S.; Pistillo, C.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Redij, A.; Reeves, M.; Reinherz-Aronis, E.; Retiere, F.; Robert, A.; Rodrigues, P. A.; Rojas, P.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smith, R. J.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suda, Y.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Szeglowski, T.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. K.; Tanaka, H. A.; Tanaka, M. M.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Ueno, K.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yen, S.; Yershov, N.; Yokoyama, M.; Yuan, T.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.; T2K Collaboration

2014-02-01

The T2K experiment has observed electron neutrino appearance in a muon neutrino beam produced 295 km from the Super-Kamiokande detector with a peak energy of 0.6 GeV. A total of 28 electron neutrino events were detected with an energy distribution consistent with an appearance signal, corresponding to a significance of 7.3σ when compared to 4.92±0.55 expected background events. In the Pontecorvo-Maki-Nakagawa-Sakata mixing model, the electron neutrino appearance signal depends on several parameters including three mixing angles θ12, θ23, θ13, a mass difference Δm322 and a CP violating phase δCP. In this neutrino oscillation scenario, assuming |Δm322|=2.4×10-3 eV2, sin2θ23=0.5, and Δm322>0 (Δm322<0), a best-fit value of sin22θ13=0.140-0.032+0.038 (0.170-0.037+0.045) is obtained at δCP=0. When combining the result with the current best knowledge of oscillation parameters including the world average value of θ13 from reactor experiments, some values of δCP are disfavored at the 90% C.L.

Absolute neutrino mass measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolf, Joachim

2011-10-06

The neutrino mass plays an important role in particle physics, astrophysics and cosmology. In recent years the detection of neutrino flavour oscillations proved that neutrinos carry mass. However, oscillation experiments are only sensitive to the mass-squared difference of the mass eigenvalues. In contrast to cosmological observations and neutrino-less double beta decay (0v2{beta}) searches, single {beta}-decay experiments provide a direct, model-independent way to determine the absolute neutrino mass by measuring the energy spectrum of decay electrons at the endpoint region with high accuracy.Currently the best kinematic upper limits on the neutrino mass of 2.2eV have been set by two experiments inmore » Mainz and Troitsk, using tritium as beta emitter. The next generation tritium {beta}-experiment KATRIN is currently under construction in Karlsruhe/Germany by an international collaboration. KATRIN intends to improve the sensitivity by one order of magnitude to 0.2eV. The investigation of a second isotope ({sup 137}Rh) is being pursued by the international MARE collaboration using micro-calorimeters to measure the beta spectrum. The technology needed to reach 0.2eV sensitivity is still in the R and D phase. This paper reviews the present status of neutrino-mass measurements with cosmological data, 0v2{beta} decay and single {beta}-decay.« less

Hypoglycemia induces tau hyperphosphorylation.

PubMed

Lee, Chu-Wan; Shih, Yao-Hsiang; Wu, Shih-Ying; Yang, Tingting; Lin, Chingju; Kuo, Yu-Min

2013-03-01

Cerebral hypoglycemia/hypometabolism is associated with Alzheimer's disease (AD) and is routinely used to assist clinical diagnosis of AD by brain imaging. However, whether cerebral hypoglycemia/hypometabolism contributes to the development of AD or is a response of reduced neuronal activity remains unclear. To investigate the causal relationship, we cultured the differentiated N2a neuroblastoma cells in glucose/pyruvate-deficient media (GDM). Shortly after the N2a cells cultured in the GDM, the mitochondria membrane potential was reduced and the AMP-activated-proteinkinase (AMPK), an energy sensor, was activated. Treatment of GDM not only increased the levels of tau phosphorylation at Ser(262) and Ser(396), but also increased the levels of active forms of GSK3α and GSK3β, two known kinases for tau phosphorylation, of the N2a cells. The levels of activated Akt, a mediator downstream to AMPK and upstream to GSK3α/β, were reduced by the GDM treatment. The effect of hypoglycemia was further examined in vivo by intracerebroventricular (icv) injection of streptozotocin (STZ) to the Wistar rats. STZ selectively injuries glucose transporter type 2-bearing cells which are primarily astrocytes in the rat brain, hence, interrupts glucose transportation from blood vessel to neuron. STZicv injection induced energy crisis in the brain regions surrounding the ventricles, as indicated by higher pAMPK levels in the hippocampus, but not cortex far away from the ventricles. STZ-icv treatment increased the levels of phosphorylated tau and activated GSK3β, but decreased the levels of activated Akt in the hippocampus. The hippocampus-dependent spatial learning and memory was impaired by the STZ-icv treatment. In conclusion, our works suggest that hypoglycemia enhances the AMPK-Akt-GSK3 pathway and leads to tau hyperphosphorylation.

Light sterile neutrinos

NASA Astrophysics Data System (ADS)

Gariazzo, S.; Giunti, C.; Laveder, M.; Li, Y. F.; Zavanin, E. M.

2016-03-01

The theory and phenomenology of light sterile neutrinos at the eV mass scale is reviewed. The reactor, gallium and Liquid Scintillator Neutrino Detector anomalies are briefly described and interpreted as indications of the existence of short-baseline oscillations which require the existence of light sterile neutrinos. The global fits of short-baseline oscillation data in 3 + 1 and 3 + 2 schemes are discussed, together with the implications for β-decay and neutrinoless double-β decay. The cosmological effects of light sterile neutrinos are briefly reviewed and the implications of existing cosmological data are discussed. The review concludes with a summary of future perspectives. This review is dedicated to the memory of Hai-Wei Long, our dear friend and collaborator, who passed away on 29 May 2015. He was an exceptionally kind person and an enthusiastic physicist. We deeply miss him.

Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy.

PubMed

Matsumoto, Gen; Matsumoto, Kazuki; Kimura, Taeko; Suhara, Tetsuya; Higuchi, Makoto; Sahara, Naruhiko; Mori, Nozomu

2018-05-17

Neurofibrillary tangles composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases collectively termed tauopathy. To understand the mechanisms underlying the cause of tauopathy, precise cellular and animal models are required. Recent data suggest that the transient introduction of exogenous tau can accelerate the development of tauopathy in the brains of non-transgenic and transgenic mice expressing wild-type human tau. However, the transmission mechanism leading to tauopathy is not fully understood. In this study, we developed cultured-cell models of tauopathy representing a human tauopathy. Neuro2a (N2a) cells containing propagative tau filaments were generated by introducing purified tau fibrils. These cell lines expressed full-length (2N4R) human tau and the green fluorescent protein (GFP)-fused repeat domain of tau with P301L mutation. Immunocytochemistry and super-resolution microscopic imaging revealed that tau inclusions exhibited filamentous morphology and were composed of both full-length and repeat domain fragment tau. Live-cell imaging analysis revealed that filamentous tau inclusions are transmitted to daughter cells, resulting in yeast-prion-like propagation. By a standard method of tau preparation, both full-length tau and repeat domain fragments were recovered in sarkosyl insoluble fraction. Hyperphosphorylation of full-length tau was confirmed by the immunoreactivity of phospho-Tau antibodies and mobility shifts by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). These properties were similar to the biochemical features of P301L mutated human tau in a mouse model of tauopathy. In addition, filamentous tau aggregates in cells barely co-localized with ubiquitins, suggesting that most tau aggregates were excluded from protein degradation systems, and thus propagated to daughter cells. The present cellular model of tauopathy will provide an advantage for dissecting

Coherent propagation of PeV neutrinos and the dip in the neutrino spectrum at IceCube

NASA Astrophysics Data System (ADS)

Kamada, Ayuki; Yu, Hai-Bo

2015-12-01

The energy spectrum of high-energy neutrinos reported by the IceCube Collaboration shows a dip between 400 TeV and 1 PeV. One intriguing explanation is that high-energy neutrinos scatter with the cosmic neutrino background through an ˜MeV mediator. Taking the density matrix approach, we develop a formalism to study the propagation of PeV neutrinos in the presence of the new neutrino interaction. If the interaction is flavored such as the gauged Lμ-Lτ model we consider, the resonant collision may not suppress the PeV neutrino flux completely. The new force mediator may also contribute to the number of effectively massless degrees of freedom in the early Universe and change the diffusion time of neutrinos from the supernova core. Astrophysical observations such as big bang nucleosynthesis and supernova cooling provide an interesting test for the explanation.

Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy.

PubMed

Puvenna, Vikram; Engeler, Madeline; Banjara, Manoj; Brennan, Chanda; Schreiber, Peter; Dadas, Aaron; Bahrami, Ashkon; Solanki, Jesal; Bandyopadhyay, Anasua; Morris, Jacqueline K; Bernick, Charles; Ghosh, Chaitali; Rapp, Edward; Bazarian, Jeffrey J; Janigro, Damir

2016-01-01

Repetitive traumatic brain injury (rTBI) is one of the major risk factors for the abnormal deposition of phosphorylated tau (PT) in the brain and chronic traumatic encephalopathy (CTE). CTE and temporal lobe epilepsy (TLE) affect the limbic system, but no comparative studies on PT distribution in TLE and CTE are available. It is also unclear whether PT pathology results from repeated head hits (rTBI). These gaps prevent a thorough understanding of the pathogenesis and clinical significance of PT, limiting our ability to develop preventative and therapeutic interventions. We quantified PT in TLE and CTE to unveil whether a history of rTBI is a prerequisite for PT accumulation in the brain. Six postmortem CTE (mean 73.3 years) and age matched control samples were compared to 19 surgically resected TLE brain specimens (4 months-58 years; mean 27.6 years). No history of TBI was present in TLE or control; all CTE patients had a history of rTBI. TLE and CTE brain displayed increased levels of PT as revealed by immunohistochemistry. No age-dependent changes were noted, as PT was present as early as 4 months after birth. In TLE and CTE, cortical neurons, perivascular regions around penetrating pial vessels and meninges were immunopositive for PT; white matter tracts also displayed robust expression of extracellular PT organized in bundles parallel to venules. Microscopically, there were extensive tau-immunoreactive neuronal, astrocytic and degenerating neurites throughout the brain. In CTE perivascular tangles were most prominent. Overall, significant differences in staining intensities were found between CTE and control (P<0.01) but not between CTE and TLE (P=0.08). pS199 tau analysis showed that CTE had the most high molecular weight tangle-associated tau, whereas epileptic brain contained low molecular weight tau. Tau deposition may not be specific to rTBI since TLE recapitulated most of the pathological features of CTE. Copyright © 2015 Elsevier B.V. All rights

Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy

PubMed Central

Puvenna, Vikram; Engeler, Madeline; Banjara, Manoj; Brennan, Chanda; Schreiber, Peter; Dadas, Aaron; Bahrami, Ashkon; Solanki, Jesal; Bandyopadhyay, Anasua; Morris, Jacqueline K.; Bernick, Charles; Ghosh, Chaitali; Bazarian, Jeffrey J.; Janigro, Damir

2016-01-01

Repetitive traumatic brain injury (rTBI) is one of the major risk factors for the abnormal deposition of phosphorylated tau (PT) in the brain and chronic traumatic encephalopathy (CTE). CTE and temporal lobe epilepsy (TLE) affect the limbic system, but no comparative studies on PT distribution in TLE and CTE are available. It is also unclear whether PT pathology results from repeated head hits (rTBI). These gaps prevent a thorough understanding of the pathogenesis and clinical significance of PT, limiting our ability to develop preventative and therapeutic interventions. We quantified PT in TLE and CTE to unveil whether a history of rTBI is a prerequisite for PT accumulation in the brain. Six post mortem CTE (mean 73.3 years) and age matched control samples were compared to 19 surgically resected TLE brain specimens (4 months-58 years; mean 27.6 years). No history of TBI was present in TLE or control; all CTE patients had a history of rTBI. TLE and CTE brain displayed increased levels of PT as revealed by immunohistochemistry. No age-dependent changes were noted, as PT was present as early as 4 months after birth. In TLE and CTE, cortical neurons, perivascular regions around penetrating pial vessels and meninges were immunopositive for PT; white matter tracts also displayed robust expression of extracellular PT organized in bundles parallel to venules. Microscopically, there were extensive tau-immunoreactive neuronal, astrocytic and degenerating neurites throughout the brain. In CTE perivascular tangles were most prominent. Overall, significant differences in staining intensities were found between CTE and control (P<0.01) but not between CTE and TLE (P=0.08). pS199 tau analysis showed that CTE had the most high molecular weight tangle-associated tau, whereas epileptic brain contained low molecular weight tau. Tau deposition may not be specific to rTBI since TLE recapitulated most of the pathological features of CTE. PMID:26556772

Neutrino Oscillations:. a Phenomenological Approach

NASA Astrophysics Data System (ADS)

Fogli, G. L.; Lisi, E.; Marrone, A.; Palazzo, A.; Rotunno, A. M.; Montanino, D.

We review the status of the neutrino oscillations physics, with a particular emphasis on the present knowledge of the neutrino mass-mixing parameters. We consider first the νμ → ντ flavor transitions of atmospheric neutrinos. It is found that standard oscillations provide the best description of the SK+K2K data, and that the associated mass-mixing parameters are determined at ±1σ (and NDF = 1) as: Δm2 = (2.6 ± 0.4) × 10-3 eV2 and sin 2 2θ = 1.00{ - 0.05}{ + 0.00} . Such indications, presently dominated by SK, could be strengthened by further K2K data. Then we point out that the recent data from the Sudbury Neutrino Observatory, together with other relevant measurements from solar and reactor neutrino experiments, in particular the KamLAND data, convincingly show that the flavor transitions of solar neutrinos are affected by Mikheyev-Smirnov-Wolfenstein (MSW) effects. Finally, we perform an updated analysis of two-family active oscillations of solar and reactor neutrinos in the standard MSW case.

Cosmological and supernova neutrinos

NASA Astrophysics Data System (ADS)

Kajino, T.; Aoki, W.; Balantekin, A. B.; Cheoun, M.-K.; Hayakawa, T.; Hidaka, J.; Hirai, Y.; Kusakabe, M.; Mathews, G. J.; Nakamura, K.; Pehlivan, Y.; Shibagaki, S.; Suzuki, T.

2014-06-01

The Big Bang nucleosynthesis (BBN) and the cosmic microwave background (CMB) anisotropies are the pillars of modern cosmology. It has recently been suggested that axion which is a dark matter candidate in the framework of the standard model could condensate in the early universe and induce photon cooling before the epoch of the photon last scattering. Although this may render a solution to the overproduction problem of primordial 7Li abundance, there arises another serious difficulty of overproducing D abundance. We propose a hybrid dark matter model with both axions and relic supersymmetric (SUSY) particles to solve both overproduction problems of the primordial D and 7Li abundances simultaneously. The BBN also serves to constrain the nature of neutrinos. Considering non-thermal photons produced in the decay of the heavy sterile neutrinos due to the magnetic moment, we explore the cosmological constraint on the strength of neutrino magnetic moment consistent with the observed light element abundances. Core-collapse supernovae eject huge flux of energetic neutrinos which affect explosive nucleosynthesis of rare isotopes like 7Li, 11B, 92Nb, 138La and 180Ta and r-process elements. Several isotopes depend strongly on the neutrino flavor oscillation due to the Mikheyev-Smirnov-Wolfenstein (MSW) effect. Combining the recent experimental constraints on θ13 with predicted and observed supernova-produced abundance ratio 11B/7Li encapsulated in the presolar grains from the Murchison meteorite, we show a marginal preference for an inverted neutrino mass hierarchy. We also discuss supernova relic neutrinos (SRN) that may indicate the softness of the equation of state (EoS) of nuclear matter and adiabatic conditions of the neutrino oscillation.

PET Imaging of Tau Deposition in the Aging Human Brain

PubMed Central

Schonhaut, Daniel R.; O’Neil, James P.; Janabi, Mustafa; Ossenkoppele, Rik; Baker, Suzanne L.; Vogel, Jacob W.; Faria, Jamie; Schwimmer, Henry D.; Rabinovici, Gil D.; Jagust, William J.

2016-01-01

SUMMARY Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid, and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition. PMID:26938442

PET Imaging of Tau Deposition in the Aging Human Brain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schöll, Michael; Lockhart, Samuel N.; Schonhaut, Daniel R.

Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. In this study, using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline inmore » global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. In conclusion, the present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition.« less

PET Imaging of Tau Deposition in the Aging Human Brain

DOE PAGES

Schöll, Michael; Lockhart, Samuel N.; Schonhaut, Daniel R.; ...

2016-03-02

Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. In this study, using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline inmore » global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. In conclusion, the present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition.« less

Quasi-Dirac neutrino oscillations

NASA Astrophysics Data System (ADS)

Anamiati, Gaetana; Fonseca, Renato M.; Hirsch, Martin

2018-05-01

Dirac neutrino masses require two distinct neutral Weyl spinors per generation, with a special arrangement of masses and interactions with charged leptons. Once this arrangement is perturbed, lepton number is no longer conserved and neutrinos become Majorana particles. If these lepton number violating perturbations are small compared to the Dirac mass terms, neutrinos are quasi-Dirac particles. Alternatively, this scenario can be characterized by the existence of pairs of neutrinos with almost degenerate masses, and a lepton mixing matrix which has 12 angles and 12 phases. In this work we discuss the phenomenology of quasi-Dirac neutrino oscillations and derive limits on the relevant parameter space from various experiments. In one parameter perturbations of the Dirac limit, very stringent bounds can be derived on the mass splittings between the almost degenerate pairs of neutrinos. However, we also demonstrate that with suitable changes to the lepton mixing matrix, limits on such mass splittings are much weaker, or even completely absent. Finally, we consider the possibility that the mass splittings are too small to be measured and discuss bounds on the new, nonstandard lepton mixing angles from current experiments for this case.

Association of Cerebrospinal Fluid β-Amyloid 1-42, T-tau, P-tau181, and α-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease

PubMed Central

Kang, Ju-Hee; Irwin, David J.; Chen-Plotkin, Alice S.; Siderowf, Andrew; Caspell, Chelsea; Coffey, Christopher S.; Waligórska, Teresa; Taylor, Peggy; Pan, Sarah; Frasier, Mark; Marek, Kenneth; Kieburtz, Karl; Jennings, Danna; Simuni, Tanya; Tanner, Caroline M.; Singleton, Andrew; Toga, Arthur W.; Chowdhury, Sohini; Mollenhauer, Brit; Trojanowski, John Q.; Shaw, Leslie M.

2014-01-01

Importance We observed a significant correlation between cerebrospinal fluid (CSF) levels of tau proteins and α-synuclein, but not β-amyloid 1–42 (Aβ1–42), and lower concentration of CSF biomarkers, as compared with healthy controls, in a cohort of entirely untreated patients with Parkinson disease (PD) at the earliest stage of the disease studied so far. Objective To evaluate the baseline characteristics and relationship to clinical features of CSF biomarkers (Aβ1–42, total tau [T-tau], tau phosphorylated at threonine 181 [P-tau181], and α-synuclein) in drug-naive patients with early PD and demographically matched healthy controls enrolled in the Parkinson’s Progression Markers Initiative (PPMI) study. Design, Setting, and Participants Cross-sectional study of the initial 102 research volunteers (63 patients with PD and 39 healthy controls) of the PPMI cohort. Main Outcomes and Measures The CSF biomarkers were measured by INNO-BIA AlzBio3 immunoassay (Aβ1–42, T-tau, and P-tau181; Innogenetics Inc) or by enzyme-linked immunosorbent assay (α-synuclein). Clinical features including diagnosis, demographic characteristics, motor, neuropsychiatric, and cognitive assessments, and DaTscan were systematically assessed according to the PPMI study protocol. Results Slightly, but significantly, lower levels of Aβ1–42, T-tau, P-tau181, α-synuclein, and T-tau/Aβ1–42 were seen in subjects with PD compared with healthy controls but with a marked overlap between groups. Using multivariate regression analysis, we found that lower Aβ1–42 and P-tau181 levels were associated with PD diagnosis and that decreased CSF T-tau and α-synuclein were associated with increased motor severity. Notably, when we classified patients with PD by their motor phenotypes, lower CSF Aβ1–42 and P-tau181 concentrations were associated with the postural instability–gait disturbance–dominant phenotype but not with the tremor-dominant or intermediate phenotype. Finally, we

A study of muon neutrino to electron neutrino oscillations in the MINOS experiment

NASA Astrophysics Data System (ADS)

Yang, Tingjun

The observation of neutrino oscillations (neutrino changing from one flavor to another) has provided compelling evidence that the neutrinos have non-zero masses and that leptons mix, which is not part of the original Standard Model of particle physics. The theoretical framework that describes neutrino oscillation involves two mass scales (Delta m2atm , and Delta m2sol ), three mixing angles (theta12, theta23, and theta13) and one CP violating phase (delta CP). Both mass scales and two of the mixing angles (theta 12 and theta23) have been measured by many neutrino experiments. The mixing angle theta13, which is believed to be very small, remains unknown. The current best limit on theta13 comes from the CHOOZ experiment: theta13 < 11° at 90% C.L. at the atmospheric mass scale. deltaCP is also unknown today. MINOS, the Main Injector Neutrino Oscillation Search, is a long baseline neutrino experiment based at Fermi National Accelerator Laboratory. The experiment uses a muon neutrino beam, which is measured 1 km downstream from its origin in the Near Detector at Fermilab and then 735 km later in the Far Detector at the Soudan mine. By comparing these two measurements, MINOS can obtain parameters in the atmospheric sector of neutrino oscillations. MINOS has published results on the precise measurement of Delta m2atm and theta23 through the disappearance of muon neutrinos in the Far Detector and on a search for sterile neutrinos by looking for a deficit in the number of neutral current interactions seen in the Far Detector. MINOS also has the potential to improve the limit on the neutrino mixing angle theta 13 or make the first measurement of its value by searching for an electron neutrino appearance signal in the Far Detector. This is the focus of the study presented in this thesis. We developed a neural network based algorithm to distinguish the electron neutrino signal from background. The most important part of this measurement is the background estimation, which is

Low-energy (anti)neutrino physics with Borexino: Neutrinos from the primary proton-proton fusion process in the Sun

NASA Astrophysics Data System (ADS)

Mosteiro, P.; Bellini, G.; Benziger, J.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Cadonati, L.; Calaprice, F.; Caminata, A.; Cavalcante, P.; Chavarría, Á.; Chepurnov, A.; D'Angelo, D.; Davini, S.; Derbin, A.; Empl, A.; Etenko, A.; Fomenko, K.; Franco, D.; Gabriele, F.; Galbiati, C.; Gazzana, S.; Ghiano, C.; Giammarchi, M.; Göger-Neff, M.; Goretti, A.; Gromov, M.; Hagner, C.; Hungerford, E.; Ianni, Al.; Ianni, An.; Kobychev, V.; Korablëv, D.; Korga, G.; Kryn, D.; Laubenstein, M.; Lehnert, B.; Lewke, T.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, I.; Manecki, S.; Maneschg, W.; Marcocci, S.; Meindl, Q.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Montuschi, M.; Muratova, V.; Oberauer, L.; Obolensky, M.; Ortica, F.; Otis, K.; Pallavicini, M.; Papp, L.; Perasso, L.; Pocar, A.; Ranucci, G.; Razeto, A.; Re, A.; Romani, A.; Rossi, N.; Saldanha, R.; Salvo, C.; Schönert, S.; Simgen, H.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Sukhotin, S.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Vignaud, D.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Winter, J.; Wojcik, M.; Wright, A.; Wurm, M.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.

2015-08-01

The Sun is fueled by a series of nuclear reactions that produce the energy that makes it shine. The primary reaction is the fusion of two protons into a deuteron, a positron and a neutrino. These neutrinos constitute the vast majority of neutrinos reaching Earth, providing us with key information about what goes on at the core of our star. Several experiments have now confirmed the observation of neutrino oscillations by detecting neutrinos from secondary nuclear processes in the Sun; this is the first direct spectral measurement of the neutrinos from the keystone proton-proton fusion. This observation is a crucial step towards the completion of the spectroscopy of pp-chain neutrinos, as well as further validation of the LMA-MSW model of neutrino oscillations.

Signature of heavy sterile neutrinos at CEPC

NASA Astrophysics Data System (ADS)

Liao, Wei; Wu, Xiao-Hong

2018-03-01

We study the production of heavy sterile neutrino N , e+e-→N ν (ν ¯), at the Circular Electron Positron Collider (CEPC) and its l j j signal in its decay to three charged fermions. We study background events for this process which are mainly events coming from W pair production. We study the production of a single heavy sterile neutrino and the sensitivity of CEPC to the mixing of the sterile neutrino with active neutrinos. We study the production of two degenerate heavy sterile neutrinos in a low energy seesaw model by taking into account the constraints on mixings of sterile neutrinos from the neutrinoless double β decay experiment and the masses and mixings of active neutrinos. We show that CEPC under proposal has a good sensitivity to the mixing of sterile neutrinos with active neutrinos for a mass of a sterile neutrino around 100 GeV.

Alzheimer disease therapy--moving from amyloid-β to tau.

PubMed

Giacobini, Ezio; Gold, Gabriel

2013-12-01

Disease-modifying treatments for Alzheimer disease (AD) have focused mainly on reducing levels of amyloid-β (Aβ) in the brain. Some compounds have achieved this goal, but none has produced clinically meaningful results. Several methodological issues relating to clinical trials of these agents might explain this failure; an additional consideration is that the amyloid cascade hypothesis--which places amyloid plaques at the heart of AD pathogenesis--does not fully integrate a large body of data relevant to the emergence of clinical AD. Importantly, amyloid deposition is not strongly correlated with cognition in multivariate analyses, unlike hyperphosphorylated tau, neurofibrillary tangles, and synaptic and neuronal loss, which are closely associated with memory deficits. Targeting tau pathology, therefore, might be more clinically effective than Aβ-directed therapies. Furthermore, numerous immunization studies in animal models indicate that reduction of intracellular levels of tau and phosphorylated tau is possible, and is associated with improved cognitive performance. Several tau-related vaccines are in advanced preclinical stages and will soon enter clinical trials. In this article, we present a critical analysis of the failure of Aβ-directed therapies, discuss limitations of the amyloid cascade hypothesis, and suggest the potential value of tau-targeted therapy for AD.

A measurement of the tau Michel parameters at SLD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quigley, James A.

1997-05-01

This thesis presents a measurement of the tau Michel parameters. This measurement utilizes the highly polarized SLC electron beam to extract these quantities directly from the measured tau decay spectra using the 1993--95 SLD sample of 4,528 tau pair events. The results are ρ e = 0.71 ± 0.14 ± 0.05, ζ e = 1.16 ± 0.52 ± 0.06, and (ζδ) e = 0.85 ± 0.43 ± 0.08 for tau decays to electrons and ρ μ = 0.54 ± 0.28 μ 0.14, η μ = -0.59 ± 0.82 ± 0.45, ζsup>μ = 0.75 ± 0.50 ± 0.14, and (ζδ) μmore » = 0.82 ± 0.32 ± 0.07 for tau decays to muons. Combining all leptonic tau decays gives ρ = 0.72 ± 0.09 ± 0.03, ζ = 1.05 ± 0.35 ± 0.04, and ζδ = 0.88 ± 0.27 ± 0.04. These results agree well with the current world average and the Standard Model.« less

Neutrino degeneracy and cosmological nucleosynthesis, revisited

NASA Technical Reports Server (NTRS)

Olive, K. A.; Schramm, David N.; Thomas, D.; Walker, T. P.

1991-01-01

A reexamination of the effects of non-zero degeneracies on Big Bang Nucleosynthesis is made. As previously noted, non-trivial alterations of the standard model conclusions can be induced only if excess lepton numbers L sub i, comparable to photon number densities eta sub tau, are assumed (where eta sub tau is approx. 3 times 10(exp 9) eta sub b). Furthermore, the required lepton number densities (L sub i eta sub tau) must be different for upsilon sub e than for upsilon sub mu and epsilon sub tau. It is shown that this loophole in the standard model of nucleosynthesis is robust and will not vanish as abundance and reaction rate determinations improve. However, it is also argued that theoretically (L sub e) approx. (L sub mu) approx. (L sub tau) approx. eta sub b is much less than eta sub tau which would preclude this loophole in standard unified models.

Nuclear physics for geo-neutrino studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fiorentini, Gianni; Istituto Nazionale di Fisica Nucleare, Sezione di Ferrara, I-44100 Ferrara; Ianni, Aldo

2010-03-15

Geo-neutrino studies are based on theoretical estimates of geo-neutrino spectra. We propose a method for a direct measurement of the energy distribution of antineutrinos from decays of long-lived radioactive isotopes. We present preliminary results for the geo-neutrinos from {sup 214}Bi decay, a process that accounts for about one-half of the total geo-neutrino signal. The feeding probability of the lowest state of {sup 214}Bi--the most important for geo-neutrino signal--is found to be p{sub 0}=0.177+-0.004 (stat){sub -0.001}{sup +0.003} (sys), under the hypothesis of universal neutrino spectrum shape (UNSS). This value is consistent with the (indirect) estimate of the table of isotopes. Wemore » show that achievable larger statistics and reduction of systematics should allow for the testing of possible distortions of the neutrino spectrum from that predicted using the UNSS hypothesis. Implications on the geo-neutrino signal are discussed.« less

Accelerator-based Neutrino Physics at Fermilab

NASA Astrophysics Data System (ADS)

Dukes, Edmond

2008-10-01

The discovery of neutrino mass has excited great interest in elucidating the properties of neutrinos and their role in nature. Experiments around the world take advantage of solar, atmospheric, reactor, and accelerator sources of neutrinos. Accelerator-based sources are particularly convenient since their parameters can be tuned to optimize the measurement in question. At Fermilab an extensive neutrino program includes the MiniBooNE, SciBooNE, and MINOS experiments. Two major new experiments, MINERvA and NOvA, are being constructed, plans for a high-intensity neutrino source to DUSEL are underway, and an R&D effort towards a large liquid argon detector is being pursued. The NOvA experiment intends to search for electron neutrino appearance using a massive surface detector 811 km from Fermilab. In addition to measuring the last unknown mixing angle, theta(13), NOvA has the possibility of seeing matter-antimatter asymmetries in neutrinos and resolving the ordering of the neutrino mass states.

Astrophysical and cosmological constraints to neutrino properties

NASA Technical Reports Server (NTRS)

Kolb, Edward W.; Schramm, David N.; Turner, Michael S.

1989-01-01

The astrophysical and cosmological constraints on neutrino properties (masses, lifetimes, numbers of flavors, etc.) are reviewed. The freeze out of neutrinos in the early Universe are discussed and then the cosmological limits on masses for stable neutrinos are derived. The freeze out argument coupled with observational limits is then used to constrain decaying neutrinos as well. The limits to neutrino properties which follow from SN1987A are then reviewed. The constraint from the big bang nucleosynthesis on the number of neutrino flavors is also considered. Astrophysical constraints on neutrino-mixing as well as future observations of relevance to neutrino physics are briefly discussed.

Tau proteins in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis.

PubMed

Yuksel, Deniz; Yilmaz, Deniz; Uyar, Neval Y; Senbil, Nesrin; Gurer, Yavuz; Anlar, Banu

2010-06-01

Neurodegenerative diseases characterized by cytoskeletal deformation and neurofibrillary tangles are associated with altered levels of tau and related proteins in cerebrospinal fluid (CSF). Neuronal or glial fibrillary tangles have been shown in 20% of subacute sclerosing panencephalitis (SSPE) patients. We therefore investigated CSF samples from 60 newly diagnosed SSPE and 31 neurological control patients for total tau (t-tau), phosphorylated tau (p-tau), and S100-B levels by ELISA. There was no difference between patient and control groups in t-tau and S100-B levels. p-Tau was lower in the SSPE group (p=0.009). Past history of measles infection, measles immunization status, latent period between measles and onset of SSPE, duration of symptoms, frequency of myoclonia, neurological deficit index, stage and progression rate of the disease, CSF glucose levels and cell counts, CSF and serum measles IgG titer, distribution of lesions on brain magnetic resonance imaging were not related to t-tau, p-tau and S100-B levels. Mental status and age were negatively correlated with t-tau, and male gender and EEG abnormalities were associated with higher t-tau levels. The levels of tau proteins in our patients suggest there is no, or only scarce and immature, neurofibrillary tangle formation in SSPE. Autopsy studies showing neurofibrillary tangles might have examined older patients with longer disease and more parenchymal involvement. Copyright (c) 2009 Elsevier B.V. All rights reserved.

Detecting the Neutrino

NASA Astrophysics Data System (ADS)

Arns, Robert G.

In 1930 Wolfgang Pauli suggested that a new particle might be required to make sense of the radioactive-disintegration mode known as beta decay. This conjecture initially seemed impossible to verify since the new particle, which became known as the neutrino, was uncharged, had zero or small mass, and interacted only insignificantly with other matter. In 1951 Frederick Reines and Clyde L. Cowan, Jr., of the Los Alamos Scientific Laboratory undertook the difficult task of detecting the free neutrino by observing its inverse beta-decay interaction with matter. They succeeded in 1956. The neutrino was accepted rapidly as a fundamental particle despite discrepancies in reported details of the experiments and despite the absence of independent verification of the result. This paper describes the experiments, examines the nature of the discrepancies, and discusses the circumstances of the acceptance of the neutrino's detection by the physics community.

Molecular & Genetic Investigation of Tau in Chronic Traumatic Encephalopathy

DTIC Science & Technology

2015-10-01

available, work will commence. Tau, genetics , susceptibility, MAPT, chronic traumatic encephalopathy, Alzheimer disease U U U U 1 USAMRMC Table of...AWARD NUMBER: W81XWH-14-1-0399 TITLE: Molecular & Genetic Investigation of Tau in Chronic Traumatic Encephalopathy PRINCIPAL INVESTIGATOR: John F...Include area code) October 2015 Annual Report 30 Sep 2014 - 29 Sep 2015 Molecular & Genetic Investigation of Tau in Chronic Traumatic Encephalopathy John

Neutrino oscillations and Non-Standard Interactions

NASA Astrophysics Data System (ADS)

Farzan, Yasaman; Tórtola, Mariam

2018-02-01

Current neutrino experiments are measuring the neutrino mixing parameters with an unprecedented accuracy. The upcoming generation of neutrino experiments will be sensitive to subdominant oscillation effects that can give information on the yet-unknown neutrino parameters: the Dirac CP-violating phase, the mass ordering and the octant of θ_{23}. Determining the exact values of neutrino mass and mixing parameters is crucial to test neutrino models and flavor symmetries designed to predict these neutrino parameters. In the first part of this review, we summarize the current status of the neutrino oscillation parameter determination. We consider the most recent data from all solar experiments and the atmospheric data from Super-Kamiokande, IceCube and ANTARES. We also implement the data from the reactor neutrino experiments KamLAND, Daya Bay, RENO and Double Chooz as well as the long baseline neutrino data from MINOS, T2K and NOvA. If in addition to the standard interactions, neutrinos have subdominant yet-unknown Non-Standard Interactions (NSI) with matter fields, extracting the values of these parameters will suffer from new degeneracies and ambiguities. We review such effects and formulate the conditions on the NSI parameters under which the precision measurement of neutrino oscillation parameters can be distorted. Like standard weak interactions, the non-standard interaction can be categorized into two groups: Charged Current (CC) NSI and Neutral Current (NC) NSI. Our focus will be mainly on neutral current NSI because it is possible to build a class of models that give rise to sizeable NC NSI with discernible effects on neutrino oscillation. These models are based on new U(1) gauge symmetry with a gauge boson of mass ≲ 10 MeV. The UV complete model should be of course electroweak invariant which in general implies that along with neutrinos, charged fermions also acquire new interactions on which there are strong bounds. We enumerate the bounds that already

Higgs production through sterile neutrinos

NASA Astrophysics Data System (ADS)

Antusch, Stefan; Cazzato, Eros; Fischer, Oliver

2016-10-01

In scenarios with sterile (right-handed) neutrinos with an approximate “lepton-number-like” symmetry, the heavy neutrinos (the mass eigenstates) can have masses around the electroweak scale and couple to the Higgs boson with, in principle, unsuppressed Yukawa couplings, while the smallness of the light neutrinos’ masses is guaranteed by the approximate symmetry. The on-shell production of the heavy neutrinos at lepton colliders, together with their subsequent decays into a light neutrino and a Higgs boson, constitutes a resonant contribution to the Higgs production mechanism. This resonant mono-Higgs production mechanism can contribute significantly to the mono-Higgs observables at future lepton colliders. A dedicated search for the heavy neutrinos in this channel exhibits sensitivities for the electron neutrino Yukawa coupling as small as ˜ 5 × 10-3. Furthermore, the sensitivity is enhanced for higher center-of-mass energies, when identical integrated luminosities are considered.

Combining nonoverlap and trend for single-case research: Tau-U.

PubMed

Parker, Richard I; Vannest, Kimberly J; Davis, John L; Sauber, Stephanie B

2011-06-01

A new index for analysis of single-case research data was proposed, Tau-U, which combines nonoverlap between phases with trend from within the intervention phase. In addition, it provides the option of controlling undesirable Phase A trend. The derivation of Tau-U from Kendall's Rank Correlation and the Mann-Whitney U test between groups is demonstrated. The equivalence of trend and nonoverlap is also shown, with supportive citations from field leaders. Tau-U calculations are demonstrated for simple AB and ABA designs. Tau-U is then field tested on a sample of 382 published data series. Controlling undesirable Phase A trend caused only a modest change from nonoverlap. The inclusion of Phase B trend yielded more modest results than simple nonoverlap. The Tau-U score distribution did not show the artificial ceiling shown by all other nonoverlap techniques. It performed reasonably well with autocorrelated data. Tau-U shows promise for single-case applications, but further study is desirable. Copyright © 2011. Published by Elsevier Ltd.

Neutrino Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kamyshkov, Yuri; Handler, Thomas

The neutrino group of the University of Tennessee, Knoxville was involved from 05/01/2013 to 04/30/2015 in the neutrino physics research funded by DOE-HEP grant DE-SC0009861. Contributions were made to the Double Chooz nuclear reactor experiment in France where second detector was commissioned during this period and final series of measurements has been started. Although Double Chooz was smaller experimental effort than competitive Daya Bay and RENO experiments, its several advantages make it valuable for understanding of systematic errors in measurements of neutrino oscillations. Double Chooz was the first experiment among competing three that produced initial result for neutrino angle θmore » 13 measurement, giving other experiments the chance to improve measured value statistically. Graduate student Ben Rybolt defended his PhD thesis on the results of Double Chooz experiment in 2015. UT group has fulfilled all the construction and analysis commitments to Double Chooz experiment, and has withdrawn from the collaboration by the end of the mentioned period to start another experiment. Larger effort of UT neutrino group during this period was devoted to the participation in another DOE-HEP project - NOvA experiment. The 14,000-ton "FAR" neutrino detector was commissioned in northern Minnesota in 2014 together with 300-ton "NEAR" detector located at Fermilab. Following that, the physics measurement program has started when Fermilab accelerator complex produced the high-intensity neutrino beam propagating through Earth to detector in MInnessota. UT group contributed to NOvA detector construction and developments in several aspects. Our Research Associate Athanasios Hatzikoutelis was managing (Level 3 manager) the construction of the Detector Control System. This work was successfully accomplished in time with the commissioning of the detectors. Group was involved in the development of the on-line software and study of the signatures of the cosmic ray backgrounds

Physics prospects of the Jinping neutrino experiment

NASA Astrophysics Data System (ADS)

Beacom, John F.; Chen, Shaomin; Cheng, Jianping; Doustimotlagh, Sayed N.; Gao, Yuanning; Gong, Guanghua; Gong, Hui; Guo, Lei; Han, Ran; He, Hong-Jian; Huang, Xingtao; Li, Jianmin; Li, Jin; Li, Mohan; Li, Xueqian; Liao, Wei; Lin, Guey-Lin; Liu, Zuowei; McDonough, William; Šrámek, Ondřej; Tang, Jian; Wan, Linyan; Wang, Yuanqing; Wang, Zhe; Wang, Zongyi; Wei, Hanyu; Xi, Yufei; Xu, Ye; Xu, Xun-Jie; Yang, Zhenwei; Yao, Chunfa; Yeh, Minfang; Yue, Qian; Zhang, Liming; Zhang, Yang; Zhao, Zhihong; Zheng, Yangheng; Zhou, Xiang; Zhu, Xianglei; Zuber, Kai

2017-02-01

The China Jinping Underground Laboratory (CJPL), which has the lowest cosmic-ray muon flux and the lowest reactor neutrino flux of any laboratory, is ideal to carry out low-energy neutrino experiments. With two detectors and a total fiducial mass of 2000 tons for solar neutrino physics (equivalently, 3000 tons for geo-neutrino and supernova neutrino physics), the Jinping neutrino experiment will have the potential to identify the neutrinos from the CNO fusion cycles of the Sun, to cover the transition phase for the solar neutrino oscillation from vacuum to matter mixing, and to measure the geo-neutrino flux, including the Th/U ratio. These goals can be fulfilled with mature existing techniques. Efforts on increasing the target mass with multi-modular neutrino detectors and on developing the slow liquid scintillator will increase the Jinping discovery potential in the study of solar neutrinos, geo-neutrinos, supernova neutrinos, and dark matter. Supported by the National Natural Science Foundation of China (11235006, 11475093, 11135009, 11375065, 11505301, and 11620101004), the Tsinghua University Initiative Scientific Research Program (20121088035, 20131089288, and 20151080432), the Key Laboratory of Particle & Radiation Imaging (Tsinghua University), the CAS Center for Excellence in Particle Physics (CCEPP), U.S. National Science Foundation Grant PHY-1404311 (Beacom), and U.S. Department of Energy under contract DE-AC02-98CH10886 (Yeh).

Cosmological bounds on neutrino statistics

NASA Astrophysics Data System (ADS)

de Salas, P. F.; Gariazzo, S.; Laveder, M.; Pastor, S.; Pisanti, O.; Truong, N.

2018-03-01

We consider the phenomenological implications of the violation of the Pauli exclusion principle for neutrinos, focusing on cosmological observables such as the spectrum of Cosmic Microwave Background anisotropies, Baryon Acoustic Oscillations and the primordial abundances of light elements. Neutrinos that behave (at least partly) as bosonic particles have a modified equilibrium distribution function that implies a different influence on the evolution of the Universe that, in the case of massive neutrinos, can not be simply parametrized by a change in the effective number of neutrinos. Our results show that, despite the precision of the available cosmological data, only very weak bounds can be obtained on neutrino statistics, disfavouring a more bosonic behaviour at less than 2σ.

Signals of HE atmospheric μ decay in flight around the Sun’s albedo versus astrophysical νμ and ντ traces in the Moon shadow

NASA Astrophysics Data System (ADS)

Fargion, Daniele; Oliva, Pietro; de Sanctis Lucentini, Pier Giorgio; Khlopov, Maxim Yu.

The Sun albedo of Cosmic Rays (CRs) at GeVs energy has been discovered recently by the FERMI satellite. They are traces of atmospheric CRs hitting solar atmosphere and reflecting skimming gamma photons. Even if relevant for astrophysics, as being a trace of atmospheric solar CR noises they cannot offer any signal of neutrino astronomy. On the contrary, the Moon with no atmosphere, may become soon a novel filtering calorimeter and an amplifier of energetic muon astronomical neutrinos (at TeV up to hundred TeVs energy); these lepton tracks leave an imprint in their beta decay while in flight to Earth. Their TeV electron air-shower are among the main signals. Also, a more energetic, but more rare, PeV up to EeV tau lunar neutrino events may be escaping as a tau lepton from the Moon: τ PeV secondaries, then, may be shining on Earth’s atmosphere in lunar shadows in a surprising way. One or a few gamma air-shower events inside the Moon shadows may occur each year in near future Cherenkov telescope array (CTA) or large high altitude air shower observatory (LHAASO) TeV gamma array detector, assuming a nonnegligible astrophysical TeV up to hundred TeV neutrino component (with respect to our terrestrial ruling atmospheric ones); these signals will open a new wonderful passe-partout keyhole for neutrino, been seen along the Moon. The lunar solid angle is small and the muon or tau expected rate is rare, but with the future largest tau radio array as the giant radio array for neutrino detection (GRAND), one might well discover such neutrino imprint.

Neutrino footprint in large scale structure

NASA Astrophysics Data System (ADS)

Garay, Carlos Peña; Verde, Licia; Jimenez, Raul

2017-03-01

Recent constrains on the sum of neutrino masses inferred by analyzing cosmological data, show that detecting a non-zero neutrino mass is within reach of forthcoming cosmological surveys. Such a measurement will imply a direct determination of the absolute neutrino mass scale. Physically, the measurement relies on constraining the shape of the matter power spectrum below the neutrino free streaming scale: massive neutrinos erase power at these scales. However, detection of a lack of small-scale power from cosmological data could also be due to a host of other effects. It is therefore of paramount importance to validate neutrinos as the source of power suppression at small scales. We show that, independent on hierarchy, neutrinos always show a footprint on large, linear scales; the exact location and properties are fully specified by the measured power suppression (an astrophysical measurement) and atmospheric neutrinos mass splitting (a neutrino oscillation experiment measurement). This feature cannot be easily mimicked by systematic uncertainties in the cosmological data analysis or modifications in the cosmological model. Therefore the measurement of such a feature, up to 1% relative change in the power spectrum for extreme differences in the mass eigenstates mass ratios, is a smoking gun for confirming the determination of the absolute neutrino mass scale from cosmological observations. It also demonstrates the synergy between astrophysics and particle physics experiments.

Cerebrospinal Fluid Amyloid-β 42, Total Tau and Phosphorylated Tau are Low in Patients with Normal Pressure Hydrocephalus: Analogies and Differences with Alzheimer's Disease.

PubMed

Santangelo, Roberto; Cecchetti, Giordano; Bernasconi, Maria Paola; Cardamone, Rosalinda; Barbieri, Alessandra; Pinto, Patrizia; Passerini, Gabriella; Scomazzoni, Francesco; Comi, Giancarlo; Magnani, Giuseppe

2017-01-01

Co-existence of Alzheimer's disease (AD) in normal pressure hydrocephalus (NPH) is a frequent finding, thus a common pathophysiological basis between AD and NPH has been postulated. We measured CSF amyloid-β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) concentrations in a sample of 294 patients with different types of dementia and 32 subjects without dementia. We then compared scores on neuropsychological tests of NPH patients with pathological and normal CSF Aβ42 values. Aβ42 levels were significantly lower in NPH than in control patients, with no significant differences between AD and NPH. On the contrary, t-tau and p-tau levels were significantly lower in NPH than in AD, with no differences between NPH and controls. NPH patients with pathological Aβ42 levels did not perform worse than NPH patients with normal Aβ42 levels in any cognitive domains. Our data seem to support the hypothesis of amyloid accumulation in brains of NPH patients. Nevertheless, amyloid does not seem to play a pathogenetic role in the development of cognitive deficits in NPH.

First all-flavor neutrino pointlike source search with the ANTARES neutrino telescope

NASA Astrophysics Data System (ADS)

Albert, A.; André, M.; Anghinolfi, M.; Anton, G.; Ardid, M.; Aubert, J.-J.; Avgitas, T.; Baret, B.; Barrios-Martí, J.; Basa, S.; Belhorma, B.; Bertin, V.; Biagi, S.; Bormuth, R.; Bourret, S.; Bouwhuis, M. C.; Brânzaş, H.; Bruijn, R.; Brunner, J.; Busto, J.; Capone, A.; Caramete, L.; Carr, J.; Celli, S.; Cherkaoui El Moursli, R.; Chiarusi, T.; Circella, M.; Coelho, J. A. B.; Coleiro, A.; Coniglione, R.; Costantini, H.; Coyle, P.; Creusot, A.; Díaz, A. F.; Deschamps, A.; de Bonis, G.; Distefano, C.; di Palma, I.; Domi, A.; Donzaud, C.; Dornic, D.; Drouhin, D.; Eberl, T.; El Bojaddaini, I.; El Khayati, N.; Elsässer, D.; Enzenhöfer, A.; Ettahiri, A.; Fassi, F.; Felis, I.; Fusco, L. A.; Galatà, S.; Gay, P.; Giordano, V.; Glotin, H.; Grégoire, T.; Gracia Ruiz, R.; Graf, K.; Hallmann, S.; van Haren, H.; Heijboer, A. J.; Hello, Y.; Hernández-Rey, J. J.; Hößl, J.; Hofestädt, J.; Hugon, C.; Illuminati, G.; James, C. W.; de Jong, M.; Jongen, M.; Kadler, M.; Kalekin, O.; Katz, U.; Kießling, D.; Kouchner, A.; Kreter, M.; Kreykenbohm, I.; Kulikovskiy, V.; Lachaud, C.; Lahmann, R.; Lefèvre, D.; Leonora, E.; Lotze, M.; Loucatos, S.; Marcelin, M.; Margiotta, A.; Marinelli, A.; Martínez-Mora, J. A.; Mele, R.; Melis, K.; Michael, T.; Migliozzi, P.; Moussa, A.; Navas, S.; Nezri, E.; Organokov, M.; Pǎvǎlaş, G. E.; Pellegrino, C.; Perrina, C.; Piattelli, P.; Popa, V.; Pradier, T.; Quinn, L.; Racca, C.; Riccobene, G.; Sánchez-Losa, A.; Saldaña, M.; Salvadori, I.; Samtleben, D. F. E.; Sanguineti, M.; Sapienza, P.; Schüssler, F.; Sieger, C.; Spurio, M.; Stolarczyk, Th.; Taiuti, M.; Tayalati, Y.; Trovato, A.; Turpin, D.; Tönnis, C.; Vallage, B.; van Elewyck, V.; Versari, F.; Vivolo, D.; Vizzoca, A.; Wilms, J.; Zornoza, J. D.; Zúñiga, J.; ANTARES Collaboration

2017-10-01

A search for cosmic neutrino sources using the data collected with the ANTARES neutrino telescope between early 2007 and the end of 2015 is performed. For the first time, all neutrino interactions—charged- and neutral-current interactions of all flavors—are considered in a search for point-like sources with the ANTARES detector. In previous analyses, only muon neutrino charged-current interactions were used. This is achieved by using a novel reconstruction algorithm for shower-like events in addition to the standard muon track reconstruction. The shower channel contributes about 23% of all signal events for an E-2 energy spectrum. No significant excess over background is found. The most signal-like cluster of events is located at (α ,δ )=(343.8 ° ,23.5 ° ) with a significance of 1.9 σ . The neutrino flux sensitivity of the search is about E2d Φ /d E =6 ×10-9 GeV cm-2 s-1 for declinations from -90 ° up to -42 ° , and below 10-8 GeV cm-2 s-1 for declinations up to 5°. The directions of 106 source candidates and 13 muon track events from the IceCube high-energy sample events are investigated for a possible neutrino signal and upper limits on the signal flux are determined.

Oligomerization of the protein tau in the Alzheimer's disease

NASA Astrophysics Data System (ADS)

Larini, Luca