Internal dosimetry technical basis manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-12-20

The internal dosimetry program at the Savannah River Site (SRS) consists of radiation protection programs and activities used to detect and evaluate intakes of radioactive material by radiation workers. Examples of such programs are: air monitoring; surface contamination monitoring; personal contamination surveys; radiobioassay; and dose assessment. The objectives of the internal dosimetry program are to demonstrate that the workplace is under control and that workers are not being exposed to radioactive material, and to detect and assess inadvertent intakes in the workplace. The Savannah River Site Internal Dosimetry Technical Basis Manual (TBM) is intended to provide a technical and philosophicalmore » discussion of the radiobioassay and dose assessment aspects of the internal dosimetry program. Detailed information on air, surface, and personal contamination surveillance programs is not given in this manual except for how these programs interface with routine and special bioassay programs.« less

Image 100 procedures manual development: Applications system library definition and Image 100 software definition

NASA Technical Reports Server (NTRS)

Guseman, L. F., Jr.; Decell, H. P., Jr.

1975-01-01

An outline for an Image 100 procedures manual for Earth Resources Program image analysis was developed which sets forth guidelines that provide a basis for the preparation and updating of an Image 100 Procedures Manual. The scope of the outline was limited to definition of general features of a procedures manual together with special features of an interactive system. Computer programs were identified which should be implemented as part of an applications oriented library for the system.

Value Engineering. Technical Manual. School Facilities Development Procedures Manual.

ERIC Educational Resources Information Center

Washington Office of the State Superintendent of Public Instruction, Olympia.

Value Engineering (VE) is a cost-optimizing technique used to analyze design quality and cost-effectiveness. The application of VE procedures to the design and construction of school facilities has been adopted by the state of Washington. This technical manual provides guidance in developing the scope and applicability of VE to school projects; in…

Pollutant Assessments Group procedures manual: Volume 2, Technical procedures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-03-01

This is volume 2 of the manuals that describes the technical procedures currently in use by the Pollution Assessments Group. This manual incorporates new developments in hazardous waste assessment technology and administrative policy. Descriptions of the equipment, procedures and operations of such things as radiation detection, soil sampling, radionuclide monitoring, and equipment decontamination are included in this manual. (MB)

Amplification in Technical Manuals: Theory and Practice.

ERIC Educational Resources Information Center

Killingsworth, M. Jimmie; And Others

1989-01-01

Examines how amplification (rhetorical techniques by which discourse is extended to enhance its appeal and information value) tends to increase and improve the coverage, rationale, warnings, behavioral alternatives, examples, previews, and general emphasis of technical manuals. Shows how classical and modern rhetorical theories can be applied to…

40 CFR Table 1 to Subpart Jjjj of... - NOX, CO, and VOC Emission Standards for Stationary Non-Emergency SI Engines ≥100 HP (Except...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false NOX, CO, and VOC Emission Standards for Stationary Non-Emergency SI Engines â¥100 HP (Except Gasoline and Rich Burn LPG), Stationary SI Landfill... Landfill/Digester Gas Engines, and Stationary Emergency Engines >25 HP Engine type and fuel Maximum engine...

The Interactive Electronic Technical Manual: Requirements, Current Status, and Implementation. Strategy Considerations.

DTIC Science & Technology

1991-07-01

authoring systems. Concurrently, great strides in computer-aided design and computer-aided maintenance have contributed to this capability. 12 Junod ...J.; William A. Nugent; and L. John Junod . Plan for the Navy/Air Force Test of the Interactive Electronic Technical Manual (IETM) at Cecil Field...AFHRL Logistics and Human Factors Division, WPAFB. Aug 1990. 12. Junod , John L. PY90 Interactive Electronic Technical Manual (IETM) Portable Delivery

Data Transfers Among the HP-75, HP-86, and HP-9845 Microcomputers.

DTIC Science & Technology

1983-01-01

AD-A139 438 DAT TRANSFERS AMONG THE HP-75 HP-86 AND HP-9845 / MICROCOMPUTENS(U) AIR FORCE INST OF TECH WNIOHT-PATTERSON AFN OH D P CONNOR 1983...hereafter called the ඓ") and the HP-86 (hereafter called the ඞ"). The computers are to be used for classroom instruction and research at SOC. On...the main campus another Hewlett-Packard desktop computer, the HP-9845 (hereafter called the 񕚕"), is already in use; it controls and processes data

General requirements to implement the personal dose equivalent Hp(10) in Brazil

NASA Astrophysics Data System (ADS)

Gomes Lopes, Amanda; Da Silva, Francisco Cesar Augusto

2018-03-01

To update the dosimetry quantity with the international community, Brazil is changing the Individual Dose (Hx) to the Personal Dose Equivalent Hp(10). A bibliographical survey on the technical and administrative requirements of nine countries that use Hp(10) was carried out to obtain the most relevant ones. All of them follow IEC and ISO guidelines for technical requirements, but administrative requirements change from country to country. Based on countries experiences, this paper presents a list of important general requirements to implement Hp(10) and to prepare the Brazilian requirements according to the international scientific community.

Improving Sex Equity in Postsecondary Vocational/Technical Programs: A Resource Manual.

ERIC Educational Resources Information Center

Lovelace, Bill E.; And Others

This manual was developed to assist postsecondary administrators, faculty, staff, and students by providing materials specifically designed to eliminate sex bias and stereotyping of students and to recruit students into nontraditional careers and vocational-technical programs. The manual is organized in six sections. The first section introduces…

FHWA Traffic Noise Model, version 1.0 technical manual

DOT National Transportation Integrated Search

1998-02-01

This Technical Manual is for the Federal Highway Administrations Traffic Noise Model (FHWA TNM), Version 1.0 -- the FHWAs computer program for highway traffic noise prediction and analysis. Two companion reports, a Users Guide and a data r...

The Job Training and Job Satisfaction Survey Technical Manual

ERIC Educational Resources Information Center

Schmidt, Steven W.

2004-01-01

Job training has become an important aspect of an employee's overall job experience. However, it is not often called out specifically on instruments measuring job satisfaction. This technical manual details the processes used in the development and validation of a survey instrument to measure job training satisfaction and overall job…

Control technology appendices for pollution control technical manuals. Final report, June 1982-February 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1983-04-01

The document is one of six technical handbooks prepared by EPA to help government officials granting permits to build synfuels facilities, synfuels process developers, and other interested parties. They provide technical data on waste streams from synfuels facilities and technologies capable of controlling them. Process technologies covered in the manuals include coal gasification, coal liquefaction by direct and idirect processing, and the extraction of oil from shale. The manuals offer no regulatory guidance, allowing the industry flexibility in deciding how best to comply with environmental regulations.

Numerical Arc Segmentation Algorithm for a Radio Conference-NASARC (version 4.0) technical manual

NASA Technical Reports Server (NTRS)

Whyte, Wayne A., Jr.; Heyward, Ann O.; Ponchak, Denise S.; Spence, Rodney L.; Zuzek, John E.

1988-01-01

The information contained in the NASARC (Version 4.0) Technical Manual and NASARC (Version 4.0) User's Manual relates to the Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC) software development through November 1, 1988. The Technical Manual describes the NASARC concept and the algorithms used to implement the concept. The User's Manual provides information on computer system considerations, installation instructions, description of input files, and program operation instructions. Significant revisions were incorporated in the Version 4.0 software over prior versions. These revisions have further enhanced the modeling capabilities of the NASARC procedure and provide improved arrangements of predetermined arcs within the geostationary orbits. Array dimensions within the software were structured to fit within the currently available 12 megabyte memory capacity of the International Frequency Registration Board (IFRB) computer facility. A piecewise approach to predetermined arc generation in NASARC (Version 4.0) allows worldwide planning problem scenarios to be accommodated within computer run time and memory constraints with enhanced likelihood and ease of solution.

HP-25 PROGRAMMABLE POCKET CALCULATOR APPLIED TO AIR POLLUTION MEASUREMENT STUDIES: STATIONARY SOURCES

EPA Science Inventory

The report should be useful to persons concerned with Air Pollution Measurement Studies of Stationary Industrial Sources. It gives detailed descriptions of 22 separate programs, written specifically for the Hewlett Packard Model HP-25 manually programmable pocket calculator. Each...

Writing Performance Goals: Strategy and Prototypes. A Manual for Vocational and Technical Educators.

ERIC Educational Resources Information Center

McGraw-Hill Book Co., New York, NY. Gregg Div.

The result of a cooperative project of the Center for Vocational and Technical Education at the Ohio State University and the McGraw-Hill Book Company, this manual was prepared to develop prototypes of performance goals for use by curriculum specialists and developers of instructional materials in vocational and technical education and to provide…

Numerical arc segmentation algorithm for a radio conference-NASARC (version 2.0) technical manual

NASA Technical Reports Server (NTRS)

Whyte, Wayne A., Jr.; Heyward, Ann O.; Ponchak, Denise S.; Spence, Rodney L.; Zuzek, John E.

1987-01-01

The information contained in the NASARC (Version 2.0) Technical Manual (NASA TM-100160) and NASARC (Version 2.0) User's Manual (NASA TM-100161) relates to the state of NASARC software development through October 16, 1987. The Technical Manual describes the Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC) concept and the algorithms used to implement the concept. The User's Manual provides information on computer system considerations, installation instructions, description of input files, and program operating instructions. Significant revisions have been incorporated in the Version 2.0 software. These revisions have enhanced the modeling capabilities of the NASARC procedure while greatly reducing the computer run time and memory requirements. Array dimensions within the software have been structured to fit within the currently available 6-megabyte memory capacity of the International Frequency Registration Board (IFRB) computer facility. A piecewise approach to predetermined arc generation in NASARC (Version 2.0) allows worldwide scenarios to be accommodated within these memory constraints while at the same time effecting an overall reduction in computer run time.

CACDA Jiffy War Game Technical Manual. Part 1: Methodology

DTIC Science & Technology

1977-03-01

Systems Analysis Office (Mr Tyburski) Fort Monmout’.h, NJ 07703 Commander 1* USAISD ATTN: ATISE-TD-TS-CD (LT Boyer) Fort Deven , MASS 01433 Commander 2...Developments Activity Fort Leavenworth, Kansas 66027 CACDA JIFFY WAR GAME TECHNICAL MANUAL Part 1: Methodology by Timothy J. Bailey and Gerald A. Martin ACN...ComrbatDevelopments Activity (CACDA), Fort Leavenworth,i-Xsas," for scenario devel- opment and force structure evaluation. The Jiffy Game computer

QUALIS OF TECHNICAL PRODUCTION: METRIC DEVELOPMENT FOR MANUALS.

PubMed

Pacheco, Adhemar Monteiro; Mendes, Carlos José Lazzarini

2015-01-01

There are few authors focused on the study of preparing manuals criteria, often criticized for methodological rigor of the information. However, it is interesting to understand what is going wrong; to understand prognosis in self-handling; in prevention of complications; in identifying better services and information; in encouraging the pursuit of excellence in the healthcare. In its preparation should be valued the basic requirements of a manual, which are: 1) wrote in simple words, being concise, efficient, clear with index or table of contents; 2) using the existing institutional rules; 3) being flexible; and 4) having ongoing process of review, update and distribution. In the process of evaluation of Medicine III manuals may have the following stratification: M4 - 100 points: when there is ISBN registration and disclosure in other languages; M3 - 75 points: registration with the ISBN only in our country; M2 - 50 points: registered in regional libraries; M1 - 25 points: manual use for inter-departmental or intra-institutional groups; M0 - 0 point: use of manual in intra-departmental teaching. In conclusion, it is known that the use of manuals is focused to the ones who do not know the subject; however, it is also an important tool that can minimize errors, avoid professional misconduct, optimize resources, and at the end allowing assessment of the subject at hand. Poucos são os autores que se debruçam no estudo dos critérios de elaboração de manuais, sendo muitas vezes criticados pelo rigor metodológico das informações. Contudo, eles são interessantes no entender o que é errado, compreender prognóstico, na autoassistência, na prevenção de complicações, para identificar melhores serviços e informações, motivando a busca pela excelência no atendimento assistencial. Em sua elaboração devem ser valorizados os requisitos básicos de um manual, que são: 1) conter redação simples, concisa, eficiente e clara, contendo índice ou sumário; 2

NUTRIENT CRITERIA TECHNICAL GUIDANCE MANUAL - ESTUARINE AND COASTAL MARINE WATERS, OCTOBER 2001

EPA Science Inventory

Nutrient overenrichment is a major cause of water pollution in the United States. The purpose of this manual is to provide scientifically defensible technical guidance to assist States, authorized Tribes, and other governmental entities in developing numeric nutrient criteria fo...

Web-Based Interactive Electronic Technical Manual (IETM) Common User Interface Style Guide, Version 2.0

DTIC Science & Technology

2003-07-01

Technical Report WEB-BASED INTERACTIVE ELECTRONIC TECHNICAL MANUAL (IETM) COMMON USER INTERFACE STYLE GUIDE Version 2.0 – July 2003 by L. John Junod ...ACKNOWLEDGEMENTS The principal authors of this document were: John Junod – NSWC, Carderock Division, Phil Deuell – AMSEC LLC, Kathleen Moore

Operating manual for the R100 digital vibration-time totalizer

USGS Publications Warehouse

Cordes, Edwin H.; Shi, Minghua

1988-01-01

A vibration sensor that monitors the running time of pumps to determine water withdrawal by various public-supply, agricultural, and industrial groups has been developed in response to a need demonstrated by data gathering activities of the U.S. Geological Survey 's National Water Use Information Program. This sensor, the R100 digital vibration-time totalizer, attaches to monitored equipment such as a pump, motor, or pipe facility and senses vibration to determine running time. Battery-powered and packaged for field environment, the R100 can be left unattended for up to 1 year. Time is recorded to the nearest 0.01 hour, or 36 seconds. This operating manual for the R100 digital vibration-time totalizer describes the R100 's principal of operation and gives installation guidelines and instructions for battery replacements. (USGS)

Cost-Benefit Analysis of a Bridge to Integrate the Management of Technical Information for Producing Technical Manuals and Training Courses

DTIC Science & Technology

2010-11-01

Philadelphia, and all Computer-Based Training (CBT) courses delivered by Navy eLearning (NeL), a part of the Naval Education and Training Command (NETC...concentrated exclu- sively on the benefit side—whether the Bridge would save money in producing future technical manuals and training courses. It...of $78.1 million in 10-year costs: a savings of $86.8 million in producing future HM&E manuals and NeL-delivered courses less $8.7 million in

HIGHLIGHTS FROM TECHNICAL MANUAL ON HOOD SYSTEM CAPTURE OF PROCESS FUGITIVE PARTICULATE EMISSIONS

EPA Science Inventory

The paper discusses a technical manual whose emphasis is on the design and evaluation of actual hood systems used to control various fugitive particulate emission sources. Engineering analyses of the most important hood types are presented to provide a conceptual understanding of...

The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471

PubMed Central

Geng, Xiwen; Li, Wen; Chen, Zhenghong; Gao, Sizhe; Hong, Wei; Ge, Xiaoran; Hou, Guihua; Hu, Zhekai; Zhou, Yabin; Zeng, Beini; Li, Wenjuan; Jia, Jihui

2017-01-01

ABSTRACT Clarithromycin (CLA) is a commonly recommended drug for Helicobacter pylori eradication. However, the prevalence of CLA-resistant H. pylori is increasing. Although point mutations in the 23S rRNA are key factors for CLA resistance, other factors, including efflux pumps and regulation genes, are also involved in the resistance of H. pylori to CLA. Guanosine 3′-diphosphate 5′-triphosphate and guanosine 3′,5′-bispyrophosphate [(p)ppGpp)], which are synthesized by the bifunctional enzyme SpoT in H. pylori, play an important role for some bacteria to adapt to antibiotic pressure. Nevertheless, no related research involving H. pylori has been reported. In addition, transporters have been found to be related to bacterial drug resistance. Therefore, this study investigated the function of SpoT in H. pylori resistance to CLA by examining the shifts in the expression of transporters and explored the role of transporters in the CLA resistance of H. pylori. A ΔspoT strain was constructed in this study, and it was shown that SpoT is involved in H. pylori tolerance of CLA by upregulating the transporters HP0939, HP1017, HP0497, and HP0471. This was assessed using a series of molecular and biochemical experiments and a cDNA microarray. Additionally, the knockout of genes hp0939, hp0471, and hp0497 in the resistant strains caused a reduction or loss (the latter in the Δhp0497 strain) of resistance to CLA. Furthermore, the average expression levels of these four transporters in clinical CLA-resistant strains were considerably higher than those in clinical CLA-sensitive strains. Taken together, our results revealed a novel molecular mechanism of H. pylori adaption to CLA stress. PMID:28242673

Technical Manual for the Conceptual Learning and Development Assessment Series IV: Tree. Technical Report No. 437. Reprinted December 1977.

ERIC Educational Resources Information Center

DiLuzio, Geneva J.; And Others

This document accompanies the Conceptual Learning and Development Assessment Series III: Tree, a test constructed to chart the conceptual development of individuals. As a technical manual, it contains information on the rationale, development, standardization, and reliability of the test, as well as essential information and statistical data for…

Technical Manual for the Conceptual Learning and Development Assessment Series III: Noun. Technical Report No. 436. Reprinted December 1977.

ERIC Educational Resources Information Center

DiLuzio, Geneva J.; And Others

This document accompanies the Conceptual Learning and Development Assessment Series IV: Noun, a test constructed to chart the conceptual development of individuals. As a technical manual, it contains information on the rationale, development, standardization, and reliability of the test, as well as essential information and statistical data for…

PRODUCTION OF HEAVY WATER SAVANNAH RIVER AND DANA PLANTS. Technical Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bebbington, W.P.; Thayer, V.R. eds.; Proctor, J.F. comp.

1959-07-01

A summary is presented of the basic technical iniormation that pertains to processes that are used at the Dana and Savannah River Plants for the production of heavy water. The manual is intended primarily for plant operating and technical personnel and was prepared to supplement and provide technical support for detailed operating procedures. Introductory sections contain some background information on the history, uses, available processes, and analytical procedures for heavy water. They also include a general comparison of the design and laserformance of the two plants and an analysis of their differences. The technology of the heavy water separation processesmore » used, namely hydrogen sulfide exchange, distillation of water, and electrolysis is discussed in detail. The manufacture and storage of hydrogen sulfide gas and the process water treatment facilities are also discussed. (auth)« less

Helicobacter pylori HP1512 Is a Nickel-Responsive NikR-Regulated Outer Membrane Protein▿

PubMed Central

Davis, Gregg S.; Flannery, Erika L.; Mobley, Harry L. T.

2006-01-01

Helicobacter pylori is dependent upon the production of the highly abundant and active metalloenzyme urease for colonization of the human stomach. Thus, H. pylori has an absolute requirement for the transition metal nickel, a required cofactor for urease. To investigate the contribution of genes that are factors in this process, microarray analysis comparing the transcriptome of wild-type H. pylori 26695 cultured in brucella broth containing fetal calf serum (BBF) alone or supplemented with 100 μM NiCl2 suggested that HP1512 is repressed in the presence of 100 μM supplemental nickel. When measured by comparative real-time quantitative PCR (qPCR), HP1512 transcription was reduced 43-fold relative to the value for the wild type when cultured in BBF supplemented with 10 μM NiCl2. When grown in unsupplemented BBF, urease activity of an HP1512::cat mutant was significantly reduced compared to the wild type, 4.9 ± 0.5 μmol/min/mg of protein (n = 7) and 17.1 ± 4.9 μmol/min/mg of protein (n = 13), respectively (P < 0.0001). In silico analysis of the HP1511-HP1512 (HP1511-1512) intergenic region identified a putative NikR operator upstream of HP1512. Gel shift analysis with purified recombinant NikR verified nickel-dependent binding of H. pylori NikR to the HP1511-1512 intergenic region. Furthermore, comparative real-time qPCR of four nickel-related genes suggests that mutation of HP1512 results in reduced intracellular nickel concentration relative to wild-type H. pylori 26695. Taken together, these data suggest that HP1512 encodes a NikR-nickel-regulated outer membrane protein. PMID:17030579

ShakeMap manual: technical manual, user's guide, and software guide

USGS Publications Warehouse

Wald, David J.; Worden, Bruce C.; Quitoriano, Vincent; Pankow, Kris L.

2005-01-01

ShakeMap (http://earthquake.usgs.gov/shakemap) --rapidly, automatically generated shaking and intensity maps--combines instrumental measurements of shaking with information about local geology and earthquake location and magnitude to estimate shaking variations throughout a geographic area. The results are rapidly available via the Web through a variety of map formats, including Geographic Information System (GIS) coverages. These maps have become a valuable tool for emergency response, public information, loss estimation, earthquake planning, and post-earthquake engineering and scientific analyses. With the adoption of ShakeMap as a standard tool for a wide array of users and uses came an impressive demand for up-to-date technical documentation and more general guidelines for users and software developers. This manual is meant to address this need. ShakeMap, and associated Web and data products, are rapidly evolving as new advances in communications, earthquake science, and user needs drive improvements. As such, this documentation is organic in nature. We will make every effort to keep it current, but undoubtedly necessary changes in operational systems take precedence over producing and making documentation publishable.

Technical Manual for the Conceptual Learning and Development Assessment Series II: Cutting Tool. Technical Report No. 435. Reprinted December 1977.

ERIC Educational Resources Information Center

DiLuzio, Geneva J.; And Others

This document accompanies Conceptual Learning and Development Assessment Series II: Cutting Tool, a test constructed to chart the conceptual development of individuals. As a technical manual, it contains information on the rationale, development, standardization, and reliability of the test, as well as essential information and statistical data…

Technical Manual for the Conceptual Learning and Development Assessment Series II: Equilateral Triangle. Technical Report No. 434. Reprinted December 1977.

ERIC Educational Resources Information Center

DiLuzio, Geneva J.; And Others

This document accompanies the Conceptual Learning and Development Assessment Series I: Equilateral Triangle, a test constructed to chart the conceptual developemnt of individuals. As a technical manual, it contains information on the rationale, development, standardization, and reliability of the test, as well as essential information and…

An Information and Technical Manual for the Computer-Assisted Teacher Training System (CATTS).

ERIC Educational Resources Information Center

Semmel, Melvyn I.; And Others

The manual presents technical information on the computer assisted teacher training system (CATTS) which aims at developing a versatile and economical computer based teacher training system with the capability of providing immediate analysis and feedback of data relevant to teacher pupil transactions in a classroom setting. The physical…

Haptoglobin genotyping of Vietnamese: global distribution of HP del, complete deletion allele of the HP gene.

PubMed

Soejima, Mikiko; Agusa, Tetsuro; Iwata, Hisato; Fujihara, Junko; Kunito, Takashi; Takeshita, Haruo; Lan, Vi Thi Mai; Minh, Tu Binh; Takahashi, Shin; Trang, Pham Thi Kim; Viet, Pham Hung; Tanabe, Shinsuke; Koda, Yoshiro

2015-01-01

The haptoglobin (HP) gene deletion allele (HP(del)) is responsible for anhaptoglobinemia and a genetic risk factor for anaphylaxis reaction after transfusion due to production of the anti-HP antibody. The distribution of this allele has been explored by several groups including ours. Here, we studied the frequency of HP(del) in addition to the distribution of common HP genotypes in 293 Vietnamese. The HP(del) was encountered with the frequency of 0.020. The present result suggested that this deletion allele is restricted to East and Southeast Asians. Thus, this allele seems to be a potential ancestry informative marker for these populations. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Utah's Best Project: Behavioral and Educational Strategies for Teachers. Technical Assistance Manuals, Edited Versions.

ERIC Educational Resources Information Center

Reavis, H. Kenton, Ed.; And Others

The 10 Technical Assistance Manuals compiled in this document were produced under cooperative agreements between the Utah State Office of Education and several school districts. Each module, an entity unto itself, is designed to assist classroom teachers with developing behavioral and educational strategies, concentrating on the objectives,…

Technical manual for manufacturing autologous fibrin tissue adhesive.

PubMed

Park, J J; Cintron, J R; Siedentop, K H; Orsay, C P; Pearl, R K; Nelson, R L; Abcarian, H

1999-10-01

The aim of this article is to provide a concise and simple technical manual for manufacturing autologous fibrin tissue adhesive derived from the precipitation of fibrinogen using a combination of ethanol and freezing for surgery. All materials and equipment needed to manufacture ethanol-based autologous fibrin tissue adhesive are listed. In addition, step-by-step instructions are provided to allow for easy and rapid fibrin adhesive production. Ethanol-based autologous fibrin tissue adhesive can be manufactured in under 60 minutes. Furthermore, at our institution the startup cost for manufacturing ethanol-based autologous fibrin tissue adhesive was under $2,500.00. Ethanol-based autologous fibrin tissue adhesive is a safe, reliable, and easily manufactured autologous fibrin tissue adhesive that can be made by a trained technician in any blood bank, pharmacy, or surgical laboratory.

Developing a Procedures Manual for Using the Innovacq 100 System Effectively and Efficiently.

ERIC Educational Resources Information Center

Cubberley, Carol

The installation of an automated acquisitions system, the Innovacq 100, demanded a review and revision of procedures in the Acquisitions Department of the University of Central Florida Library. This practicum report describes the process involved in developing the new procedures. Prior to installation, the old departmental procedures manual and…

The NASA/MSFC global reference atmospheric model: 1990 version (GRAM-90). Part 1: Technical/users manual

NASA Technical Reports Server (NTRS)

Justus, C. G.; Alyea, F. N.; Cunnold, D. M.; Jeffries, W. R., III; Johnson, D. L.

1991-01-01

A technical description of the NASA/MSFC Global Reference Atmospheric Model 1990 version (GRAM-90) is presented with emphasis on the additions and new user's manual descriptions of the program operation aspects of the revised model. Some sample results for the new middle atmosphere section and comparisons with results from a three dimensional circulation model are provided. A programmer's manual with more details for those wishing to make their own GRAM program adaptations is also presented.

User's manual for The TIM benefit-cost (TIM-BC) Tool (Version: 1.0.0)

DOT National Transportation Integrated Search

2015-07-04

This document serves as a users manual for the Traffic Incident Management Benefit-Cost Tool (TIM-BC) Version 1.0.0 - Safety Service Patrol Benefit-Cost (SSP-BC) Tool, which is used to assist State and local engineers and decisionmakers with evalu...

Jobsite Supervisor Instructor's Manual for Electrical Apprentice Technical Training. Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

One hundred and sixteen lesson plans for a first, second, third and fourth year electrical apprentice technical training program are presented in this manual. The lesson plans are generally organized into four steps: introducing the lesson, presenting the lessons (e.g., demonstration), student application (use of worksheets), and checking and…

Exploring Perceptions and Attitudes towards Teaching and Learning Manual Technical Drawing in a Digital Age

ERIC Educational Resources Information Center

McLaren, Susan Valerie

2008-01-01

This paper examines the place of manual technical drawing in the 21st century by discussing the perceived value and relevance of teaching school students how to draw using traditional instruments, in a world of computer aided drafting (CAD). Views were obtained through an e-survey, questionnaires and structured interviews. The sample groups…

Auto Mechanics; Methodology. Technical Instruction Manual.

ERIC Educational Resources Information Center

Systems Operation Support, Inc., King of Prussia, PA.

This student instruction manual was written in conformance with selected criteria for programed instruction books as developed previously for various military training courses. The manual was developed as a part of "A Study of the Effectiveness of a Military-Type Computer-Based Instructional System When Used in Civilian High School Courses in…

Financing Options for Home Care for Children with Chronic Illness and Severe Disability. Technical Assistance Manual.

ERIC Educational Resources Information Center

Ellison, Marsha Langer; And Others

This manual is intended to accompany technical assistance efforts aimed at improving selected states' home health care programs for children with chronic illness and severe disability. Summary descriptions of funding sources are presented, including purpose, eligibility guidelines, and services covered, as well as additional information as…

Transcriptional Profiling of Type II Toxin-Antitoxin Genes of Helicobacter pylori under Different Environmental Conditions: Identification of HP0967-HP0968 System.

PubMed

Cárdenas-Mondragón, María G; Ares, Miguel A; Panunzi, Leonardo G; Pacheco, Sabino; Camorlinga-Ponce, Margarita; Girón, Jorge A; Torres, Javier; De la Cruz, Miguel A

2016-01-01

Helicobacter pylori is a Gram-negative bacterium that colonizes the human gastric mucosa and is responsible for causing peptic ulcers and gastric carcinoma. The expression of virulence factors allows the persistence of H. pylori in the stomach, which results in a chronic, sometimes uncontrolled inflammatory response. Type II toxin-antitoxin (TA) systems have emerged as important virulence factors in many pathogenic bacteria. Three type II TA systems have previously been identified in the genome of H. pylori 26695: HP0315-HP0316, HP0892-HP0893, and HP0894-HP0895. Here we characterized a heretofore undescribed type II TA system in H. pylori , HP0967-HP0968, which is encoded by the bicistronic operon hp0968-hp0967 and belongs to the Vap family. The predicted HP0967 protein is a toxin with ribonuclease activity whereas HP0968 is an antitoxin that binds to its own regulatory region. We found that all type II TA systems were expressed in H. pylori during early stationary growth phase, and differentially expressed in the presence of urea, nickel, and iron, although, the hp0968-hp0967 pair was the most affected under these environmental conditions. Transcription of hp0968-hp0967 was strongly induced in a mature H. pylori biofilm and when the bacteria interacted with AGS epithelial cells. Kanamycin and chloramphenicol considerably boosted transcription levels of all the four type II TA systems. The hp0968-hp0967 TA system was the most frequent among 317 H. pylori strains isolated from all over the world. This study is the first report on the transcription of type II TA genes in H. pylori under different environmental conditions. Our data show that the HP0967 and HP0968 proteins constitute a bona fide type II TA system in H. pylori , whose expression is regulated by environmental cues, which are relevant in the context of infection of the human gastric mucosa.

Improvement of mathematical models for simulation of vehicle handling : volume 7 : technical manual for the general simulation

DOT National Transportation Integrated Search

1980-03-01

This volume is the technical manual for the general simulation. Mathematical modelling of the vehicle and of the human driver is presented in detail, as are differences between the APL simulation and the current one. Information on model validation a...

NREL Research Earns Two Prestigious R&D 100 Awards | News | NREL

Science.gov Websites

R&D 100 Awards July 11, 2014 A growth system that can produce thin solar cells quickly and at NREL's other R&D 100 award, in collaboration with HP, was for the HP Apollo 8000 System. This

General Drafting. Technical Manual.

ERIC Educational Resources Information Center

Department of the Army, Washington, DC.

The manual provides instructional guidance and reference material in the principles and procedures of general drafting and constitutes the primary study text for personnel in drafting as a military occupational specialty. Included is information on drafting equipment and its use; line weights, conventions and formats; lettering; engineering charts…

SATNET development and operation. Pluribus satellite IMP development. Remote site maintenance. Internet operations and maintenance. Mobile access terminal network. TCP for the HP3000. TCP-TAC. TCP for VAX-UNIX. Combined quarterly technical report

NASA Astrophysics Data System (ADS)

Bressler, R. D.

1981-11-01

This quarterly technical report describes work on the development of and experimentation with packet broadcast by satellite; on development of Pluribus Satellite IMPs; on a study of the technology of Remote Site Maintenance; on Internetwork monitoring; on shipboard satellite communications; and on the development of Transmission Control Protocols for the HP3000, TAC, and VAX-UNIX.

'Buildings in Use' Study. Technical Factors.

ERIC Educational Resources Information Center

Wisconsin Univ., Milwaukee. School of Architecture and Urban Planning.

The second report of the 'Buildings in Use' study documents the results of over 100 field tests conducted at four elementary schools, as well as discussion of these results and relevant technical specifications and details. The procedural framework used in the Field Tests Manual is followed and test results are rated numerically wherever possible.…

Transcriptional Profiling of Type II Toxin–Antitoxin Genes of Helicobacter pylori under Different Environmental Conditions: Identification of HP0967–HP0968 System

PubMed Central

Cárdenas-Mondragón, María G.; Ares, Miguel A.; Panunzi, Leonardo G.; Pacheco, Sabino; Camorlinga-Ponce, Margarita; Girón, Jorge A.; Torres, Javier; De la Cruz, Miguel A.

2016-01-01

Helicobacter pylori is a Gram-negative bacterium that colonizes the human gastric mucosa and is responsible for causing peptic ulcers and gastric carcinoma. The expression of virulence factors allows the persistence of H. pylori in the stomach, which results in a chronic, sometimes uncontrolled inflammatory response. Type II toxin–antitoxin (TA) systems have emerged as important virulence factors in many pathogenic bacteria. Three type II TA systems have previously been identified in the genome of H. pylori 26695: HP0315–HP0316, HP0892–HP0893, and HP0894–HP0895. Here we characterized a heretofore undescribed type II TA system in H. pylori, HP0967–HP0968, which is encoded by the bicistronic operon hp0968–hp0967 and belongs to the Vap family. The predicted HP0967 protein is a toxin with ribonuclease activity whereas HP0968 is an antitoxin that binds to its own regulatory region. We found that all type II TA systems were expressed in H. pylori during early stationary growth phase, and differentially expressed in the presence of urea, nickel, and iron, although, the hp0968–hp0967 pair was the most affected under these environmental conditions. Transcription of hp0968–hp0967 was strongly induced in a mature H. pylori biofilm and when the bacteria interacted with AGS epithelial cells. Kanamycin and chloramphenicol considerably boosted transcription levels of all the four type II TA systems. The hp0968–hp0967 TA system was the most frequent among 317 H. pylori strains isolated from all over the world. This study is the first report on the transcription of type II TA genes in H. pylori under different environmental conditions. Our data show that the HP0967 and HP0968 proteins constitute a bona fide type II TA system in H. pylori, whose expression is regulated by environmental cues, which are relevant in the context of infection of the human gastric mucosa. PMID:27920769

New approach to calculate the true-coincidence effect of HpGe detector

NASA Astrophysics Data System (ADS)

Alnour, I. A.; Wagiran, H.; Ibrahim, N.; Hamzah, S.; Siong, W. B.; Elias, M. S.

2016-01-01

The corrections for true-coincidence effects in HpGe detector are important, especially at low source-to-detector distances. This work established an approach to calculate the true-coincidence effects experimentally for HpGe detectors of type Canberra GC3018 and Ortec GEM25-76-XLB-C, which are in operation at neutron activation analysis lab in Malaysian Nuclear Agency (NM). The correction for true-coincidence effects was performed close to detector at distances 2 and 5 cm using 57Co, 60Co, 133Ba and 137Cs as standard point sources. The correction factors were ranged between 0.93-1.10 at 2 cm and 0.97-1.00 at 5 cm for Canberra HpGe detector; whereas for Ortec HpGe detector ranged between 0.92-1.13 and 0.95-100 at 2 and 5 cm respectively. The change in efficiency calibration curve of the detector at 2 and 5 cm after correction was found to be less than 1%. Moreover, the polynomial parameters functions were simulated through a computer program, MATLAB in order to find an accurate fit to the experimental data points.

SEE Action Guide for States: Guidance on Establishing and Maintaining Technical Reference Manuals for Energy Efficiency Measures

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2017-06-01

The goal of this guide is to support the development, maintenance, and use of accurate and reliable Technical Reference Manuals (TRMs). TRMs provide information primarily used for estimating the energy and demand savings of end-use energy efficiency measures associated with utility customer-funded efficiency programs.

New approach to calculate the true-coincidence effect of HpGe detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alnour, I. A., E-mail: aaibrahim3@live.utm.my, E-mail: ibrahim.elnour@yahoo.com; Wagiran, H.; Ibrahim, N.

The corrections for true-coincidence effects in HpGe detector are important, especially at low source-to-detector distances. This work established an approach to calculate the true-coincidence effects experimentally for HpGe detectors of type Canberra GC3018 and Ortec GEM25-76-XLB-C, which are in operation at neutron activation analysis lab in Malaysian Nuclear Agency (NM). The correction for true-coincidence effects was performed close to detector at distances 2 and 5 cm using {sup 57}Co, {sup 60}Co, {sup 133}Ba and {sup 137}Cs as standard point sources. The correction factors were ranged between 0.93-1.10 at 2 cm and 0.97-1.00 at 5 cm for Canberra HpGe detector; whereas for Ortec HpGemore » detector ranged between 0.92-1.13 and 0.95-100 at 2 and 5 cm respectively. The change in efficiency calibration curve of the detector at 2 and 5 cm after correction was found to be less than 1%. Moreover, the polynomial parameters functions were simulated through a computer program, MATLAB in order to find an accurate fit to the experimental data points.« less

ARES: automated response function code. Users manual. [HPGAM and LSQVM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maung, T.; Reynolds, G.M.

This ARES user's manual provides detailed instructions for a general understanding of the Automated Response Function Code and gives step by step instructions for using the complete code package on a HP-1000 system. This code is designed to calculate response functions of NaI gamma-ray detectors, with cylindrical or rectangular geometries.

17. VIEW SOUTHEAST OF 450 HP TURBINE IN BASEMENT OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. VIEW SOUTHEAST OF 450 HP TURBINE IN BASEMENT OF GRANITEVILLE MILL. THE MAIN BEARING OF THE TURBINE IS AT LEFT CENTER OF THE PHOTOGRAPH. A LOMBARD REGULATOR CAN BE SEEN AT THE LEFT CENTER REAR. THE LARGE HANDWHEEL AT THE LEFT CENTER IS GEARED TO A SECTIONAL GEAR AT THE CENTER OF THE PHOTOGRAPH AND IS USED TO MANUALLY OPEN THE GATES AND ALLOW WATER INTO THE TURBINE. THE SMALL PULLEY ON THE END OF THE MAIN SHAFT NORMALLY WOULD HAVE A BELT CONNECTING IT TO A PULLEY ON THE LOMBARD REGULATOR. THIS BELT TRANSMITTED TURBINE SPEED (RPM) TO THE LOMBARD WHICH WOULD OPEN OR CLOSE THE GATES TO KEEP TURBINE SPEED CONSTANT UNDER VARYING LOADS. THIS TURBINE WAS INSTALLED IN THE REFIT OF 1912. - Graniteville Mill, Marshall Street, Graniteville, Aiken County, SC

Instructor's Manual for Electrical Apprentice Technical Training. Series No. D (Fourth Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Twenty-seven lesson plans for a fourth-year electrical apprentice technical training program are presented in this instructor's manual. Also included are student worksheets and information sheets for each lesson, and copies of unit tests. (Answers to the worksheets and tests are provided.) The lesson plans are generally organized into four steps:…

Instructor's Manual for Electrical Apprentice Technical Training. Series No. A (First Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Thirty-six lesson plans for the first of a four-year electrical apprentice technical training program are presented in this instructor's manual. Also included are student worksheets and information sheets for each lesson, and copies of unit tests. (Answers to the worksheets and tests are provided.) The lesson plans are generally organized into…

Instructor's Manual for Electrical Apprentice Technical Training. Series No. B (Second Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Twenty-eight lesson plans for the second year of a four-year electrical apprentice technical training program are presented in this instructor's manual. Also included are student worksheets and information sheets for each lesson, and copies of unit tests. (Answers to the worksheets and tests are provided.) The lesson plans are generally organized…

Satellite freeze forecast system. System configuration definition manual

NASA Technical Reports Server (NTRS)

Martsolf, J. D. (Principal Investigator)

1983-01-01

Equipment listings, interconnection information, and a basic overview is given of the hardware interaction of the Ruskin HP-100 computer system. A block diagram is included of the SFFS system at the National Weather Service Office in Ruskin, Florida. The generation answer file used to create the RTE-IVB operating system currently resident in Ruskin HP-1000 computer system is also described.

Practical Electronics. Technical Instruction Manual.

ERIC Educational Resources Information Center

Systems Operation Support, Inc., King of Prussia, PA.

This student instruction manual was developed as a part of "A Study of The Effectiveness of a Military-Type Computer-Based Instructional System When Used in Civilian High School Courses in Electronics and Auto Mechanics." (VT 006 916). The material emphasizes a troubleshooting strategy for repair of equipment based upon a logical and systematic…

Vocational-Technical Physics Project. Instructor's Manual. Field Test Edition.

ERIC Educational Resources Information Center

Forsyth Technical Inst., Winston-Salem, NC.

This instructor's manual in vocational physics consists of five modules: Jacks, Thermometers, The Alternator, The Pool Table, and The Radiator. It is an individualized approach, designed for use with accompanying student manuals on each of the individual modules. Each module in the instructor's manual consists of a general description plus an…

HP3 on ExoMars - Cutting airbag cloths with the sharp tip of a mechanical mole

NASA Astrophysics Data System (ADS)

Krause, C.; Izzo, M.; Re, E.; Mehls, C.; Richter, L.; Coste, P.

2009-04-01

The HP3 - Heat Flow and Physical Properties Package - is planned to be one of the Humboldt lander-based instruments on the ESA ExoMars mission. HP3 will allow the measurement of the subsurface temperature gradient and physical as well as thermophysical properties of the subsurface regolith of Mars down to a depth of 5 meters. From these measurements, the planetary heat flux can be inferred. The HP³ instrument package consists of a mole trailing a package of thermal and electrical sensors into the regolith. Beside the payload elements Thermal Excitation and Measurement Suite and a Permittivity Probe the HP3 experiment includes sensors to detect the forward motion and the tilt of the HP3 payload compartment. The HP3 experiment will be integrated into the lander platform of the ExoMars mission. The original accommodation featured a deployment device or a robotic arm to place HP3 onto the soil outside the deflated lander airbags. To avoid adding such deployment devices, it was suggested that the HP3 mole should be capable of piercing the airbags under the lander. The ExoMars lander airbag is made of 4 Kevlar layers (2 abrasive and 2 bladders). A double fold of the airbag (a worst case) would represent a pile of 12 layers. An exploratory study has examined the possibility of piercing airbag cloths by adding sharp cutting blades on the tip of a penetrating mole. In the experimental setup representative layers were laid over a Mars soil simulant. Initial tests used a hammer-driven cutting tip and had moderate to poor results. More representative tests used a prototype of the HP3 mole and were fully successful: the default 4 layer configuration was pierced as well as the 12 layer configuration, the latter one within 3 hours and about 3000 mole strokes This improved behaviour is attributed to the use of representative test hardware where guidance and suppression of mole recoil were concerned. The presentation will provide an explanation of the technical requirements on

Development and validation of sensitive LC-MS/MS assays for quantification of HP-β-CD in human plasma and CSF

PubMed Central

Jiang, Hui; Sidhu, Rohini; Fujiwara, Hideji; De Meulder, Marc; de Vries, Ronald; Gong, Yong; Kao, Mark; Porter, Forbes D.; Yanjanin, Nicole M.; Carillo-Carasco, Nuria; Xu, Xin; Ottinger, Elizabeth; Woolery, Myra; Ory, Daniel S.; Jiang, Xuntian

2014-01-01

2-Hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used excipient for drug formulation, has emerged as an investigational new drug for the treatment of Niemann-Pick type C1 (NPC1) disease, a neurodegenerative cholesterol storage disorder. Development of a sensitive quantitative LC-MS/MS assay to monitor the pharmacokinetics (PKs) of HP-β-CD required for clinical trials has been challenging owing to the dispersity of the HP-β-CD. To support a phase 1 clinical trial for ICV delivery of HP-β-CD in NPC1 patients, novel methods for quantification of HP-β-CD in human plasma and cerebrospinal fluid (CSF) using LC-MS/MS were developed and validated: a 2D-LC-in-source fragmentation-MS/MS (2D-LC-IF-MS/MS) assay and a reversed phase ultra performance LC-MS/MS (RP-UPLC-MS/MS) assay. In both assays, protein precipitation and “dilute and shoot” procedures were used to process plasma and CSF, respectively. The assays were fully validated and in close agreement, and allowed determination of PK parameters for HP-β-CD. The LC-MS/MS methods are ∼100-fold more sensitive than the current HPLC assay, and were successfully employed to analyze HP-β-CD in human plasma and CSF samples to support the phase 1 clinical trial of HP-β-CD in NPC1 patients. PMID:24868096

Structuring of manual of orientations and technical information for laundries of industries of animal products origin.

PubMed

da Silva, Vania Eugênia; Mafra, Simone Caldas Tavares; Mafra, Cláudio Lísias; de Souza, Amaury Paulo

2012-01-01

This study looked for to lift information regarding laundries inserted in industries of animal products origin, to understand the activities developed in the section and to structure a Manual of Planning and Technical Information for laundries to industries of animal products origin, with the intention of subsidizing the planning, structuring and control of this work place, because norms or regulations that supervise don't exist or aid their managers and workers as for the operation of this work place.

Marine safety manual, volume 4 : technical

DOT National Transportation Integrated Search

2005-01-01

A comprehensive manual which provides guidance on the application of Coast Guard regulations and explains the rationale behind their development is vital to the successful execution of the marine safety program. This volume is intended to serve that ...

[Manual rotation of occiput posterior presentation].

PubMed

Le Ray, C; Goffinet, F

2011-10-01

Delivery in occiput posterior position is associated with a higher risk of cesarean section, operative vaginal delivery and severe perineal tears. We report the technic of manual rotation described by Tarnier and Chantreuil and used daily in our maternity center. Only five studies were published on this topic; all of them demonstrate that manual rotation decreases the risk of cesarean section. Moreover, it could decrease the risk of prolonged second stage, chorioamnionitis and third and fourth degree tears in comparison with expectant management. However, manual rotation is associated with a two-fold higher risk of cervical and vaginal lacerations. Manual rotation performed with an adequate technic is an efficient and safe manœuvre to avoid complications associated with occiput posterior vaginal delivery. Copyright © 2011. Published by Elsevier SAS.

HpBase: A genome database of a sea urchin, Hemicentrotus pulcherrimus.

PubMed

Kinjo, Sonoko; Kiyomoto, Masato; Yamamoto, Takashi; Ikeo, Kazuho; Yaguchi, Shunsuke

2018-04-01

To understand the mystery of life, it is important to accumulate genomic information for various organisms because the whole genome encodes the commands for all the genes. Since the genome of Strongylocentrotus purpratus was sequenced in 2006 as the first sequenced genome in echinoderms, the genomic resources of other North American sea urchins have gradually been accumulated, but no sea urchin genomes are available in other areas, where many scientists have used the local species and reported important results. In this manuscript, we report a draft genome of the sea urchin Hemincentrotus pulcherrimus because this species has a long history as the target of developmental and cell biology in East Asia. The genome of H. pulcherrimus was assembled into 16,251 scaffold sequences with an N50 length of 143 kbp, and approximately 25,000 genes were identified in the genome. The size of the genome and the sequencing coverage were estimated to be approximately 800 Mbp and 100×, respectively. To provide these data and information of annotation, we constructed a database, HpBase (http://cell-innovation.nig.ac.jp/Hpul/). In HpBase, gene searches, genome browsing, and blast searches are available. In addition, HpBase includes the "recipes" for experiments from each lab using H. pulcherrimus. These recipes will continue to be updated according to the circumstances of individual scientists and can be powerful tools for experimental biologists and for the community. HpBase is a suitable dataset for evolutionary, developmental, and cell biologists to compare H. pulcherrimus genomic information with that of other species and to isolate gene information. © 2018 Japanese Society of Developmental Biologists.

Status and Opportunities for Improving the Consistency of Technical Reference Manuals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jayaweera, Tina; Velonis, Aquila; Haeri, Hossein

Across the United States, energy-efficiency program administrators rely on Technical Reference Manuals (TRMs) as sources for calculations and deemed savings values for specific, well-defined efficiency measures. TRMs play an important part in energy efficiency program planning by providing a common and consistent source for calculation of ex ante and often ex post savings. They thus help reduce energy-efficiency resource acquisition costs by obviating the need for extensive measurement and verification and lower performance risk for program administrators and implementation contractors. This paper considers the benefits of establishing region-wide or national TRMs and considers the challenges of such undertaking due tomore » the difficulties in comparing energy savings across jurisdictions. We argue that greater consistency across TRMs in the approaches used to determine deemed savings values, with more transparency about assumptions, would allow better comparisons in savings estimates across jurisdictions as well as improve confidence in reported efficiency measure savings. To support this thesis, we review approaches for the calculation of savings for select measures in TRMs currently in use in 17 jurisdictions. The review reveals differences in the saving methodologies, technical assumptions, and input variables used for estimating deemed savings values. These differences are described and their implications are summarized, using four, common energy-efficiency measures as examples. Recommendations are then offered for establishing a uniform approach for determining deemed savings values.« less

Battery Test Manual For Electric Vehicles, Revision 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Christophersen, Jon P.

2015-06-01

This battery test procedure manual was prepared for the United States Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Vehicle Technologies Office. It is based on technical targets for commercial viability established for energy storage development projects aimed at meeting system level DOE goals for Electric Vehicles (EV). The specific procedures defined in this manual support the performance and life characterization of advanced battery devices under development for EVs. However, it does share some methods described in the previously published battery test manual for plug-in hybrid electric vehicles. Due to the complexity of some of themore » procedures and supporting analysis, future revisions including some modifications and clarifications of these procedures are expected. As in previous battery and capacitor test manuals, this version of the manual defines testing methods for full-size battery systems, along with provisions for scaling these tests for modules, cells or other subscale level devices. The DOE-United States Advanced Battery Consortium (USABC), Technical Advisory Committee (TAC) supported the development of the manual. Technical Team points of contact responsible for its development and revision are Chul Bae of Ford Motor Company and Jon P. Christophersen of the Idaho National Laboratory. The development of this manual was funded by the Unites States Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Technical direction from DOE was provided by David Howell, Energy Storage R&D Manager and Hybrid Electric Systems Team Leader. Comments and questions regarding the manual should be directed to Jon P. Christophersen at the Idaho National Laboratory (jon.christophersen@inl.gov).« less

Intact EAV-HP Endogenous Retrovirus in Sonnerat's Jungle Fowl

PubMed Central

Sacco, M. A.; Howes, K.; Venugopal, K.

2001-01-01

The EAV-HP group of chicken endogenous retrovirus elements was previously shown to be defective, with large deletions of the pol gene. In this report, we demonstrate that genomes of other Gallus species also maintain EAV-HP elements with similar deletions. The chicken EAV-HP1 locus was detected in both red (Gallus gallus gallus) and Sonnerat's (Gallus sonneratii) jungle fowl with identical integration sites, indicating that these elements had integrated before separation of the Gallus species. Furthermore, we demonstrate for the first time that the G. sonneratii genome carries EAV-HP elements with intact pol regions. PMID:11160706

Effective Instructional Leadership Act--Technical Assistance Manual for Instructional Leaders, and Training Program Providers, July 1, 2004-June 30, 2006.

ERIC Educational Resources Information Center

Kentucky Department of Education, 2004

2004-01-01

The Kentucky Department of Education, Office of Leadership and School Improvement developed this revised and updated technical assistance manual for the 2004-2006 Effective Instructional Leadership Act (EILA) cycle to assist local educators as they strive to improve the quality and effectiveness of their leadership skills and to assist districts…

FIELD CHECK MANUAL FOR LANGUAGE LABORATORIES, A SERIES OF TESTS WHICH A NON-TECHNICAL PERSON CAN CONDUCT TO VERIFY SPECIFICATIONS.

ERIC Educational Resources Information Center

GRITTNER, FRANK; PAVLAT, RUSSELL

IN ORDER TO ASSIST NON-TECHNICAL PEOPLE IN SCHOOLS TO CONDUCT A FIELD CHECK OF LANGUAGE LABORATORY EQUIPMENT BEFORE THEY MAKE FINAL PAYMENTS, THIS MANUAL OFFERS CRITERIA, TESTS, AND METHODS OF SCORING THE QUALITY OF THE EQUIPMENT. CHECKLISTS ARE PROVIDED FOR EVALUATING CONSOLE FUNCTIONS, TAPE RECORDERS, AMPLIFIERS, SOUND QUALITY (INCLUDING…

Development and validation of sensitive LC-MS/MS assays for quantification of HP-β-CD in human plasma and CSF.

PubMed

Jiang, Hui; Sidhu, Rohini; Fujiwara, Hideji; De Meulder, Marc; de Vries, Ronald; Gong, Yong; Kao, Mark; Porter, Forbes D; Yanjanin, Nicole M; Carillo-Carasco, Nuria; Xu, Xin; Ottinger, Elizabeth; Woolery, Myra; Ory, Daniel S; Jiang, Xuntian

2014-07-01

2-Hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used excipient for drug formulation, has emerged as an investigational new drug for the treatment of Niemann-Pick type C1 (NPC1) disease, a neurodegenerative cholesterol storage disorder. Development of a sensitive quantitative LC-MS/MS assay to monitor the pharmacokinetics (PKs) of HP-β-CD required for clinical trials has been challenging owing to the dispersity of the HP-β-CD. To support a phase 1 clinical trial for ICV delivery of HP-β-CD in NPC1 patients, novel methods for quantification of HP-β-CD in human plasma and cerebrospinal fluid (CSF) using LC-MS/MS were developed and validated: a 2D-LC-in-source fragmentation-MS/MS (2D-LC-IF-MS/MS) assay and a reversed phase ultra performance LC-MS/MS (RP-UPLC-MS/MS) assay. In both assays, protein precipitation and "dilute and shoot" procedures were used to process plasma and CSF, respectively. The assays were fully validated and in close agreement, and allowed determination of PK parameters for HP-β-CD. The LC-MS/MS methods are ∼100-fold more sensitive than the current HPLC assay, and were successfully employed to analyze HP-β-CD in human plasma and CSF samples to support the phase 1 clinical trial of HP-β-CD in NPC1 patients. Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.

78 FR 22367 - Proposed Information Collection (Service Data Manual) Activity: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... technical medical equipment and devices or mechanical equipment. DATES: Written comments and recommendations... manuals and maintenance/repair manuals when technical medical equipment and devices, or mechanical...

Mitotic Mysteries: The Case of HP1.

PubMed

Higgins, Jonathan M G; Prendergast, Lisa

2016-03-07

The role of Heterochromatin Protein-1 (HP1) during mitosis has been controversial. Two recent studies in Science and Developmental Cell, from Tanno et al. (2015) and Abe et al. (2016), suggest that the means of HP1 localization and its function at inner centromeres are altered in cancer cells with chromosomal instability. Copyright © 2016 Elsevier Inc. All rights reserved.

TADS Needs Assessment Procedures Manual, Summer 1980.

ERIC Educational Resources Information Center

Black, Talbot; And Others

The TADS (Technical Assistance Development System) Needs Assessment Manual is designed to guide the comprehensive review of Handicapped Children's Early Education Program (HCEEP) demonstration projects in identifying technical assistance needs. An introduction reviews the TADS technical assistance model which includes program planning, needs…

Technical report writing

NASA Technical Reports Server (NTRS)

Vidoli, Carol A.

1992-01-01

This manual covers the fundamentals of organizing, writing, and reviewing NASA technical reports. It was written to improve the writing skills of LeRC technical authors and the overall quality of their reports.

Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters.

PubMed

Manyam, Bala V; Dhanasekaran, Muralikrishnan; Hare, Theodore A

2004-02-01

HP-200, which contains Mucuna pruriens endocarp, has been shown to be effective in the treatment of Parkinson's disease. Mucuna pruriens endocarp has also been shown to be more effective compared to synthetic levodopa in an animal model of Parkinson's disease. The present study was designed to elucidate the long-term effect of Mucuna pruriens endocarp in HP-200 on monoaminergic neurotransmitters and its metabolite in various regions of the rat brain. HP-200 at a dose of 2.5, 5.0 or 10.0 g/kg/day was mixed with rat chow and fed daily ad lib to Sprague-Dawley rats (n = 6 for each group) for 52 weeks. Controls (n = 6) received no drug. Random assignment was made for doses and control. The rats were sacrificed at the end of 52 weeks and the neurotransmitters were analyzed in the cortex, hippocampus, substantia nigra and striatum. Oral administration of Mucuna pruriens endocarp in the form of HP-200 had a significant effect on dopamine content in the cortex with no significant effect on levodopa, norepinephrine or dopamine, serotonin, and their metabolites- HVA, DOPAC and 5-HIAA in the nigrostriatal tract. The failure of Mucuna pruriens endocarp to significantly affect dopamine metabolism in the striatonigral tract along with its ability to improve Parkinsonian symptoms in the 6-hydorxydopamine animal model and humans may suggest that its antiparkinson effect may be due to components other than levodopa or that it has an levodopa enhancing effect. Copyright 2004 John Wiley & Sons, Ltd. Copyright 2004 John Wiley & Sons, Ltd.

Resource Manual for Functional Vision Evaluation. Technical Assistance Bulletin.

ERIC Educational Resources Information Center

Texas Education Agency, Austin. Div. of Special Education.

The manual was intended to help school personnel (either an educator of the visually handicapped and/or a certified orientation and mobility instructor) evaluate the functional use of residual vision. The manual is organized in three major sections, which cover the following: (1) the general areas addressed in functional vision evaluation (such as…

HP-1γ Controls High-Affinity Antibody Response to T-Dependent Antigens

PubMed Central

Ha, Ngoc; Pham, Duc-Hung; Shahsafaei, Aliakbar; Naruse, Chie; Asano, Masahide; Thai, To-Ha

2014-01-01

In vitro observations suggest a role for the mouse heterochromatin protein 1γ (HP-1γ) in the immune system. However, it has not been shown if and how HP-1γ contributes to immunity in vivo. Here we show that in mice, HP-1γ positively regulates the germinal center reaction and high-affinity antibody response to thymus (T)-dependent antigens by limiting the size of CD8+ regulatory T-cell (Treg) compartment without affecting progenitor B- or T-cell-development. Moreover, HP-1γ does not control cell proliferation or class switch recombination. Haploinsufficiency of cbx-3 (gene encoding HP-1γ) is sufficient to expand the CD8+ Treg population and impair the immune response in mice despite the presence of wild-type HP-1α and HP-1β. This is the first in vivo evidence demonstrating the non-redundant role of HP-1γ in immunity. PMID:24971082

Global investigations of the satellite-based Fugro OmniSTAR HP service

NASA Astrophysics Data System (ADS)

Pflugmacher, Andreas; Heister, Hansbert; Heunecke, Otto

2009-12-01

OmniSTAR is one of the world's leading suppliers of satellite-based augmentation services for onshore and offshore GNSS applications. OmniSTAR currently offers three services: VBS, HP and XP. OmniSTAR VBS is the code-based service, suitable for sub-metre positioning accuracy. The HP and XP services provide sub-decimetre accuracy, with the HP service based on a precise differential methodology and the XP service uses precise absolute positioning. The sub-decimetre HP and XP services both have distinctive convergence behaviour, and the positioning task is essentially a time-dependent process during which the accuracy of the estimated coordinates continuously improves over time. To validate the capabilities of the OmniSTAR services, and in particular the HP (High Performance) service, globally distributed measurement campaigns were performed. The results of these investigations confirm that the HP service satisfies its high accuracy specification, but only after a sufficient initialisation phase. Two kinds of disturbances can handicap HP operation: lack of GNSS observations and outages of the augmentation signal. The most serious kind of disturbance is the former. Within a few seconds the achieved convergence level is completely lost. Outages in the reception of augmentation data merely affect the relevant period of the outage - the accuracy during the outage is degraded. Only longer interruptions lead to a loss of the HP solution. When HP convergence is lost, the HP process has to be re-initialized. If there are known points (so-called “seed points”) available, a shortened “kick-start”-initialization is possible. With the aid of seed points it only takes a few minutes to restore convergence.

The Hughes HS601HP spacecraft power subsystem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krummann, W.; Ayvazian, H.

1998-07-01

The introduction of the Hughes HS 601HP (high power) spacecraft product line continuous the highly successful HS601 three axis stabilized geosynchronus spacecraft with increased power capabilities for larger payload applications. The enhanced power capabilities of the HS 601HP are built upon the heritage of 29 HS601 spacecraft presently in operation. The HS 601HP accommodates payload power ranges of 3 to 7 kilowatts and provides a smooth transition from the lower power HS 601 spacecraft to the HS 702 spacecraft, which has a payload capability up to 13 kilowatts. The HS 601HP spacecraft is designed for a 15 year life withmore » minimal operator interaction. The HS 601HP power subsystem provides a regulated power bus with a voltage range of 52 to 53 volts during all operational phases. The power subsystem is tailored to the specific needs of the spacecraft by selecting standard products from the HS 601HP power catalog. The solar arrays, battery, power control electronics and power distribution electronics are all modular and configurable to the requirements of the spacecraft. The HS 601HP solar array is the primary power source for the spacecraft. The solar array is comprised of two sets of planar solar panels (solar wings) which track the sun in a single spacecraft axis. The solar cells are selected from three different types based upon the spacecraft power generation requirements; silicon, single junction gallium arsenide or dual junction gallium arsenide. The maximum power capability at end of life (15 years, summer solstice) ranges from 4 to 7.7 kilowatts for the three types of solar cells. The HS 601HP battery is the power source for the spacecraft during eclipse and peak sunlight power periods. The battery is comprised of four individual battery packs connected in series to produce a single battery. Each battery pack can accommodate a maximum of eight battery cells with a capacity of 350 ampere-hours. The battery pack also provides for mounting of all

MARSAME Manual and Resources

EPA Pesticide Factsheets

MARSAME provides technical information on survey approaches to determine proper disposition of materials and equipment (M&E). MARSAME is a supplement to the Multi-Agency Radiation Survey and Site Investigation Manual (MARSSIM).

Development and analytical performance evaluation of FREND-SAA and FREND-Hp

NASA Astrophysics Data System (ADS)

Choi, Eunha; Seong, Jihyun; Lee, Seiyoung; Han, Sunmi

2017-07-01

The FREND System is a portable cartridge reader, quantifying analytes by measuring laser-induced fluorescence in a single-use reagent cartridge. The objective of this study was to evaluate FREND-SAA and FREND-Hp assays. The FREND-SAA and Hp assays were standardized to the WHO and IFCC reference materials. Analytical performance studies of Precision, Linearity, Limits of Detections, Interferences, and Method Comparisons for both assays were performed according to the CLSI guidelines. Both assays demonstrated acceptable imprecision of %CV in three different levels of samples. The linearity of the assays was found to be acceptable (SAA 5 150 mg/L, Hp 30 400 mg/dL). The detection limits were 3.8 mg/L (SAA) and 10.2 mg/dL (Hp). No significant interference and no significant deviation from linearity was found in the both comparison studies. In conclusion, NanoEnTek's FREND-SAA and Hp assays represent rapid, accurate and convenient means to quantify SAA and Hp in human serum on FREND system.

Typing Postal Cards. Student's Manual and Instructor's Manual.

ERIC Educational Resources Information Center

Snapp, Jane

Supporting performance objective 85 of the V-TECS (Vocational-Technical Education Consortium of States) Secretarial Catalog, both a set of student materials and an instructor's manual on typing postal cards are included in this packet. (The packet is the seventh in a set of fifteen on typewriting--CE 016 920-934.) The student materials include a…

The h-p Version of the Finite Element Method.

DTIC Science & Technology

1985-07-01

commerical code (released in 1985) using the p and h-p versions. The h-p version combines the h and p-versions. The p-version was first theoretically studied ...satisfied 121 L1]- We will study the approximation (in the space H1 ) of functions u B2 ,d 2) by the h-p version and will show that exponential rate...where its various properties were studied . Let us mention the following lemma proven in [51 which will be needed r later. 2 2 0- Lemma 2.1. H5 (0 ) C

Redesigned PDC bit solves low hydraulic hp problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-06-01

A new PDC bit design was created to solve a problem a drilling contractor had due to hydraulic horsepower limitations on rigs used in a particular geographical area. The new bit design, which arose from a formal alliance between Exeter Drilling Co. and Hughes Christensen Co. has greatly improved bit cleaning and overall drilling efficiency in applications where only low hydraulic hp is available. The new design has been run successfully in the Denver-Julesburg (D-J) basin of Colorado. The development was described in detail in paper IADC/SPE 35109, ``Unique PDC bit configuration dramatically improves hole cleaning, drilling efficiency in lowmore » hydraulic applications,`` presented by G.J. Hertzler III, Exeter Drilling Co. and J.T. Wankier, Hughes Christensen Co., at the 1996 IADC/SPE Drilling Conference, New Orleans, La., March 12--15. This article is an abstract of that paper, which contains significantly more technical data.« less

Radiological control manual. Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kloepping, R.

1996-05-01

This Lawrence Berkeley National Laboratory Radiological Control Manual (LBNL RCM) has been prepared to provide guidance for site-specific additions, supplements and interpretation of the DOE Radiological Control Manual. The guidance provided in this manual is one methodology to implement the requirements given in Title 10 Code of Federal Regulations Part 835 (10 CFR 835) and the DOE Radiological Control Manual. Information given in this manual is also intended to provide demonstration of compliance to specific requirements in 10 CFR 835. The LBNL RCM (Publication 3113) and LBNL Health and Safety Manual Publication-3000 form the technical basis for the LBNL RPPmore » and will be revised as necessary to ensure that current requirements from Rules and Orders are represented. The LBNL RCM will form the standard for excellence in the implementation of the LBNL RPP.« less

Economic Evaluation of Building Design, Construction, Operation and Maintenance. Instructor's Manual.

ERIC Educational Resources Information Center

Ruegg, Rosalie T.; Marshall, Harold E.

This instructor's manual describes each section of a 3-day technical seminar on how to measure the economic impact of alternative designs, systems, and operation and maintenance strategies in federal buildings. The manual was prepared to help instructors of the General Services Administration conduct technically sound and comprehensive seminars.…

Robotic-Assisted Versus Manual Prostatic Arterial Embolization for Benign Prostatic Hyperplasia: A Comparative Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bagla, Sandeep, E-mail: sandeep.bagla@gmail.com; Smirniotopoulos, John; Orlando, Julie C.

PurposeProstatic artery embolization (PAE) is a safe and efficacious procedure for benign prostatic hyperplasia (BPH), though is technically challenging. We present our experience of technical and clinical outcomes of robotic and manual PAE in patients with BPH.Materials and MethodsIRB-approved retrospective study of 40 consecutive patients 49–81 years old with moderate or severe grade BPH from May 2014 to July 2015: 20 robotic-assisted PAE (group 1), 20 manual PAE (group 2). Robotic-assisted PAE was performed using the Magellan Robotic System. American Urological Association (AUA-SI) score, cost, technical and clinical success, radiation dose, fluoroscopy, and procedure time were reviewed. Statistical analysis was performedmore » within and between each group using paired t test and one-way analysis of variance respectively, at 1 and 3 months.ResultsNo significant baseline differences in age and AUA-SI between groups. Technical success was 100% (group 1) and 95% (group 2). One unsuccessful subject from group 2 returned for a successful embolization using robotic assistance. Fluoroscopy and procedural times were similar between groups, with a non-significant lower patient radiation dose in group 1 (30,632.8 mGy/cm{sup 2} vs 35,890.9, p = 0.269). Disposable cost was significantly different between groups with the robotic-assisted PAE incurring a higher cost (group 1 $4530.2; group 2 $1588.5, p < 0.0001). Clinical improvement was significant in both arms at 3 months: group 1 mean change in AUA-SI of 8.3 (p = 0.006), group 2: 9.6 (p < 0.0001). No minor or major complications occurred.ConclusionsRobotic-assisted PAE offers technical success comparable to manual PAE, with similar clinical improvement with an increased cost.« less

Robotic-Assisted Versus Manual Prostatic Arterial Embolization for Benign Prostatic Hyperplasia: A Comparative Analysis.

PubMed

Bagla, Sandeep; Smirniotopoulos, John; Orlando, Julie C; Piechowiak, Rachel

2017-03-01

Prostatic artery embolization (PAE) is a safe and efficacious procedure for benign prostatic hyperplasia (BPH), though is technically challenging. We present our experience of technical and clinical outcomes of robotic and manual PAE in patients with BPH. IRB-approved retrospective study of 40 consecutive patients 49-81 years old with moderate or severe grade BPH from May 2014 to July 2015: 20 robotic-assisted PAE (group 1), 20 manual PAE (group 2). Robotic-assisted PAE was performed using the Magellan Robotic System. American Urological Association (AUA-SI) score, cost, technical and clinical success, radiation dose, fluoroscopy, and procedure time were reviewed. Statistical analysis was performed within and between each group using paired t test and one-way analysis of variance respectively, at 1 and 3 months. No significant baseline differences in age and AUA-SI between groups. Technical success was 100% (group 1) and 95% (group 2). One unsuccessful subject from group 2 returned for a successful embolization using robotic assistance. Fluoroscopy and procedural times were similar between groups, with a non-significant lower patient radiation dose in group 1 (30,632.8 mGy/cm 2 vs 35,890.9, p = 0.269). Disposable cost was significantly different between groups with the robotic-assisted PAE incurring a higher cost (group 1 $4530.2; group 2 $1588.5, p < 0.0001). Clinical improvement was significant in both arms at 3 months: group 1 mean change in AUA-SI of 8.3 (p = 0.006), group 2: 9.6 (p < 0.0001). No minor or major complications occurred. Robotic-assisted PAE offers technical success comparable to manual PAE, with similar clinical improvement with an increased cost.

How Single-site Mutation Affects HP Lattice Proteins

NASA Astrophysics Data System (ADS)

Shi, Guangjie; Landau, David P.; Vogel, Thomas; Wüst, Thomas; Li, Ying Wai

2014-03-01

We developed a heuristic method based on Wang-Landauand multicanonical sampling for determining the ground-state degeneracy of HP lattice proteins . Our algorithm allowed the most precise estimations of the (sometimes substantial) ground-state degeneracies of some widely studied HP sequences. We investigated the effects of single-site mutation on specific long HP lattice proteins comprehensively, including structural changes in ground-states, changes of ground-state degeneracy and thermodynamic properties of the systems. Both extremely sensitive and insensitive cases have been observed; consequently, properties such as specific heat, tortuosities etc. may be either largely unaffected or may change significantly due to mutation. More interestingly, mutation can even induce a lower ground-state energy in a few cases. Supported by NSF.

The 3600 hp split-torque helicopter transmission

NASA Technical Reports Server (NTRS)

White, G.

1985-01-01

Final design details of a helicopter transmission that is powered by GE twin T 700 engines each rated at 1800 hp are presented. It is demonstrated that in comparison with conventional helicopter transmission arrangements the split torque design offers: weight reduction of 15%; reduction in drive train losses of 9%; and improved reliability resulting from redundant drive paths between the two engines and the main shaft. The transmission fits within the NASA LeRC 3000 hp Test Stand and accepts the existing positions for engine inputs, main shaft, connecting drive shafts, and the cradle attachment points. One necessary change to the test stand involved gear trains of different ratio in the tail drive gearbox. Progressive uprating of engine input power from 3600 to 4500 hp twin engine rating is allowed for in the design. In this way the test transmission will provide a base for several years of analytical, research, and component development effort targeted at improving the performance and reliability of helicopter transmission.

Design of an advanced 500-HP helicopter transmission

NASA Technical Reports Server (NTRS)

Braddock, C. E.

1982-01-01

A 500-hp Advanced Technology Demonstrator helicopter transmission was designed by an American aerospace company under a NASA contract. The project was mainly concerned with designing a 500-hp version of the OH-58C 317-hp transmission which would have the capabilities for a long, quiet life at a minimum increase in cost, weight, and space, which usually increase along with power increases. This objective was accomplished by implementing advanced technology which has been developed during the last decade and by making improvements dictated by field experience. The improvements are related to bearings made of cleaner gear steels, spiral bevel gears made of cleaner gear steels, high contact ratio spur gear teeth in the planetary which will reduce noise level and increase gear life, and modifications concerning the sun gear.

Filing Alphabetically. Basic Rules. Student's Manual and Instructor's Manual.

ERIC Educational Resources Information Center

McLeod, Sadie

Supporting performance objectives 21, 25, and 26 of the V-TECS (Vocational-Technical Education Consortium of States) Secretarial Catalog, both a set of student materials and an instructor's manual on the basic rules of filing alphabetically are included in this packet. (The packet is the first in a set of nine on maintaining files and a…

TFaNS Tone Fan Noise Design/Prediction System. Volume 1; System Description, CUP3D Technical Documentation and Manual for Code Developers

NASA Technical Reports Server (NTRS)

Topol, David A.

1999-01-01

TFaNS is the Tone Fan Noise Design/Prediction System developed by Pratt & Whitney under contract to NASA Lewis (presently NASA Glenn). The purpose of this system is to predict tone noise emanating from a fan stage including the effects of reflection and transmission by the rotor and stator and by the duct inlet and nozzle. These effects have been added to an existing annular duct/isolated stator noise prediction capability. TFaNS consists of: The codes that compute the acoustic properties (reflection and transmission coefficients) of the various elements and write them to files. Cup3D: Fan Noise Coupling Code that reads these files, solves the coupling problem, and outputs the desired noise predictions. AWAKEN: CFD/Measured Wake Postprocessor which reformats CFD wake predictions and/or measured wake data so it can be used by the system. This volume of the report provides technical background for TFaNS including the organization of the system and CUP3D technical documentation. This document also provides information for code developers who must write Acoustic Property Files in the CUP3D format. This report is divided into three volumes: Volume I: System Description, CUP3D Technical Documentation, and Manual for Code Developers; Volume II: User's Manual, TFaNS Vers. 1.4; Volume III: Evaluation of System Codes.

Quartermaster 1 and C, Rate Training Manual.

ERIC Educational Resources Information Center

Naval Personnel Program Support Activity, Washington, DC.

The technical subject matter of the Quartermaster rating is presented in this training manual written to prepare men of the Navy and Naval Reserve for advancement examinations. The manual includes eleven chapters. Discussed are commonly used methods and procedures of operating magnetic compasses and gyrocompasses, determining a ship's position,…

Radiological Defense Manual.

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Washington, DC.

Originally prepared for use as a student textbook in Radiological Defense (RADEF) courses, this manual provides the basic technical information necessary for an understanding of RADEF. It also briefly discusses the need for RADEF planning and expected postattack emergency operations. There are 14 chapters covering these major topics: introduction…

Thermal spray manual for machinery components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Travis, R.; Ginther, C.; Herbstritt, M.

1995-12-31

The Thermal Spray Manual For Machinery Components is a National Shipbuilding Research (SP-7) Project. This Manual is being developed by Puget Sound Naval Shipyard with the help of other government thermal spray facilities and SP-7 panel members. The purpose of the manual is to provide marine repair facilities with a ``how to do`` document that will be ``user friendly`` and known to be technically sound through production experience. The manual`s intent is to give marine repair facilities the ability to maximize the thermal spray process as a repair method for machinery components and to give these facilities guidelines on howmore » to become qualified to receive certification that they meet the requirements of Military Standard 1687A.« less

46 CFR 11.335 - Requirements to qualify for an STCW endorsement as an electro-technical officer on vessels...

Code of Federal Regulations, 2014 CFR

2014-10-01

... electro-technical officer on vessels powered by main propulsion machinery of 750 kW/1,000 HP or more... propulsion machinery of 750 kW/1,000 HP or more (operational level). (a) To qualify for an STCW endorsement... electronics. (iii) Integrated navigation equipment. (iv) Ship propulsion and auxiliary machinery. (v...

Writing Clinic for Business and Technical Writers.

ERIC Educational Resources Information Center

Mercer County Community Coll., Trenton, NJ.

This document offers brief lesson plans for four courses: (1) an 8-hour refresher course for employees who write memos, short reports, and letters; (2) an 8-hour refresher course on creating a short document; (3) a 16-hour course on technical manual writing; and (4) an 8-hour course on technical manual writing. The courses were part of a workplace…

ASSIST internals reference manual

NASA Technical Reports Server (NTRS)

Johnson, Sally C.; Boerschlein, David P.

1994-01-01

The Abstract Semi-Markov Specification Interface to the SURE Tool (ASSIST) program was developed at NASA LaRC in order to analyze the reliability of virtually any fault-tolerant system. A user manual was developed to detail its use. Certain technical specifics are of no concern to the end user, yet are of importance to those who must maintain and/or verify the correctness of the tool. This document takes a detailed look into these technical issues.

Haptoglobin polymorphism among Saharian and West African groups. Haptoglobin phenotype determination by radioimmunoelectrophoresis on Hp O samples.

PubMed Central

Constans, J; Viau, M; Gouaillard, C; Clerc, A

1981-01-01

The haptoglobin (Hp) polymorphism is investigated in 11 African groups living in an area from the Algerian Sahara to Central Africa. More than 4,000 samples were examined. In the Saharian samples, the Hp1 gene frequency is higher than in any other African group. From north to south, a decrease in the Hp1 gene frequency is observed; in the Pygmy sample only, this frequency is lower than the frequency of the Hp2 gene. By means of a sensitive radioimmunoelectrophoresis, the presence of a residual Hp in Hp O sera in which the Hp polymorphism can also be determined can be revealed. Absence of Hp 1-1 and significant excess of Hp 2-2 individuals were observed. More Hp 2-1M phenotypes were detected in the Hp O population than in the non-Hp O population examined. In the Hp O samples, the influence of the phenotype distribution on the Hp gene frequencies is discussed. The heavy polymers of the Hp related to the presence of the alpha 2 chain (Hp2 gene product) are involved only in the biological mechanisms responsible for the presence of Hp O and Hp 2-1 M phenotypes among African groups. Images Fig. 1 PMID:7258189

IPM for Pennsylvania Schools: A How-To Manual.

ERIC Educational Resources Information Center

Martz, Eston, Ed.

This manual presents practical advice on planning and adopting an integrated pest management (IPM) program for Pennsylvania educational facilities. The manual covers how to implement a school IPM, school IPM operational information for the school administrator, and technical information for Pennsylvania schools concerning various pests found in…

Manual of Accreditation Standards for Adventure Programs 1995.

ERIC Educational Resources Information Center

Williamson, John E., Comp.; Gass, Michael, Comp.

This manual presents standards for adventure education programs seeking accreditation from the Association for Experiential Education. The manual is set up sequentially, focusing both on objective standards such as technical risk management aspects, and on subjective standards such as teaching approaches used in programs. Chapter titles provide…

Rotor Wake/Stator Interaction Noise Prediction Code Technical Documentation and User's Manual

NASA Technical Reports Server (NTRS)

Topol, David A.; Mathews, Douglas C.

2010-01-01

This report documents the improvements and enhancements made by Pratt & Whitney to two NASA programs which together will calculate noise from a rotor wake/stator interaction. The code is a combination of subroutines from two NASA programs with many new features added by Pratt & Whitney. To do a calculation V072 first uses a semi-empirical wake prediction to calculate the rotor wake characteristics at the stator leading edge. Results from the wake model are then automatically input into a rotor wake/stator interaction analytical noise prediction routine which calculates inlet aft sound power levels for the blade-passage-frequency tones and their harmonics, along with the complex radial mode amplitudes. The code allows for a noise calculation to be performed for a compressor rotor wake/stator interaction, a fan wake/FEGV interaction, or a fan wake/core stator interaction. This report is split into two parts, the first part discusses the technical documentation of the program as improved by Pratt & Whitney. The second part is a user's manual which describes how input files are created and how the code is run.

Small Enterprise Development Pre-Service Training Manual. Training for Development. Peace Corps Information Collection & Exchange Training Manual No. T-42.

ERIC Educational Resources Information Center

Pragma Corp., Falls Church, VA.

This manual is intended to assist Peace Corps trainers in providing preservice technical training in small enterprise development. The manual includes a total of 40 training sessions divided among 10 learning modules. The following topics are covered: the main principles of small enterprise development; Peace Corps volunteers as small enterprise…

Tools and Their Uses. Rate Training Manual.

ERIC Educational Resources Information Center

Naval Personnel Program Support Activity, Washington, DC.

One of a series of training manuals prepared for enlisted personnel in the Navy and Naval Reserve, this supplementary manual contains data pertinent to a variety of tools necessary to the satisfactory performance of modern technical equipment used by the Navy. It is designed to help the learner identify tools and fastening devices by their correct…

Microbial ecology laboratory procedures manual NASA/MSFC

NASA Technical Reports Server (NTRS)

Huff, Timothy L.

1990-01-01

An essential part of the efficient operation of any microbiology laboratory involved in sample analysis is a standard procedures manual. The purpose of this manual is to provide concise and well defined instructions on routine technical procedures involving sample analysis and methods for monitoring and maintaining quality control within the laboratory. Of equal importance is the safe operation of the laboratory. This manual outlines detailed procedures to be followed in the microbial ecology laboratory to assure safety, analytical control, and validity of results.

Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung.

PubMed

Abdullah, Mahdi; Goldmann, Torsten

2012-11-20

Since the existence of pHp was demonstrated, it has been shown that this molecule and its receptor CD163 are regulated by different stimuli. Furthermore, a comparably fast secretion of pHp was described as well as the immuno-stimulatory effects. The intention of this study was to elucidate the role of pHp in the human lungs further. Here we show, by means of confocal microscopy and immune-electron-microscopy, a clear co-localization of pHp with surfactant protein-B in lamellar bodies of alveolar epithelial cells type II. These results are underlined by immunohistochemical stainings in differently fixed human lung tissues, which show pHp in vesicular and released form. The images of the released form resemble the intended position of surfactant in the human alveolus. pHp is secreted by Alveolar epithelial cells type II as previously shown. Moreover, pHp is co-localized with Surfactant protein-B. We conclude that the presented data shows that pHp is a native part of the surfactant system in the human lung. http://www.diagnosticpathology.diagnomx.eu/vs/2563584738239912.

GILA User's Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

CHRISTON, MARK A.

2003-06-01

GILA is a finite element code that has been developed specifically to attack the class of transient, incompressible, viscous, fluid dynamics problems that are predominant in the world that surrounds us. The purpose for this document is to provide sufficient information for an experienced analyst to use GILA in an effective way. The GILA User's Manual presents a technical outline of the governing equations for time-dependent incompressible flow, and the explicit and semi-implicit projection methods used in GILA to solve the equations. This manual also presents a brief overview of some of GILA's capabilities along with the keyword input syntaxmore » and sample problems.« less

Marketing information: The technical report as product

NASA Technical Reports Server (NTRS)

Stoher, F. F.; Pinelli, T. E.

1981-01-01

Technical reports constitute a product, the primary means for communicating the results of research to the user. The Langley scientific and technical information (STI) review and evaluation project undertook a review of the technical report as an effective product for information communication. Style manuals describing theory and practice in technical report preparation; publication manuals covering such factors as design, layout, and type style; and copies of technical reports were obtained from industrial, academic, governmental, and research organizations. Based on an analysis of this material, criteria will be established for the report components, for the relationship of the components within the report context, and for the overall report organization. The criteria will be used as bench marks and compared with the publication standards currently used to prepare NASA technical reports.

High- and Low-mobility Populations of HP1 in Heterochromatin of Mammalian CellsD⃞

PubMed Central

Schmiedeberg, Lars; Weisshart, Klaus; Diekmann, Stephan; Meyer zu Hoerste, Gabriele; Hemmerich, Peter

2004-01-01

Heterochromatin protein 1 (HP1) is a conserved nonhistone chromosomal protein with functions in euchromatin and heterochromatin. Here we investigated the diffusional behaviors of HP1 isoforms in mammalian cells. Using fluorescence correlation spectroscopy (FCS) and fluorescence recovery after photobleaching (FRAP) we found that in interphase cells most HP1 molecules (50–80%) are highly mobile (recovery halftime: t1/2 ≈ 0.9 s; diffusion coefficient: D ≈ 0.6–0.7 μm2 s-1). Twenty to 40% of HP1 molecules appear to be incorporated into stable, slow-moving oligomeric complexes (t1/2 ≈ 10 s), and constitutive heterochromatin of all mammalian cell types analyzed contain 5–7% of very slow HP1 molecules. The amount of very slow HP1 molecules correlated with the chromatin condensation state, mounting to more than 44% in condensed chromatin of transcriptionally silent cells. During mitosis 8–14% of GFP-HP1α, but not the other isoforms, are very slow within pericentromeric heterochromatin, indicating an isoform-specific function of HP1α in heterochromatin of mitotic chromosomes. These data suggest that mobile as well as very slow populations of HP1 may function in concert to maintain a stable conformation of constitutive heterochromatin throughout the cell cycle. PMID:15064352

Stress corrosion evaluation of HP 9Ni-4Co-0.30C steel plate welds

NASA Technical Reports Server (NTRS)

Torres, Pablo D.

1993-01-01

A stress corrosion cracking (SCC) investigation was conducted on HP 9Ni-4Co-0.30C steel plate welds (welded by using straight polarity plasma arc and HP 9Ni-4Co-0.20C weld wire) since this material is being considered for use in the Advanced Solid Rocket Motor (ASRM) program. Prior to the welding, the material was double tempered at 538 C (1,000 F). After welding, only part of the material was stress relieved at 510 C (950 F) for 3 h. Round tensile specimens obtained from nonstress-relieved material were tested in 100-percent relative humidity at 38 C (100 F), in 3.5-percent NaCl alternate immersion, and in 5-percent salt spray at 35 C (95 F). Specimens obtained from stress-relieved material were tested in alternate immersion. The stress levels were 50, 75, and 90 percent of the corresponding 0.2-percent yield strength (YS). All the nonstress-relieved specimens exposed to salt spray and alternate immersion failed. Stress-relieved specimens (exposed to alternate immersion) failed at 75 and 90 percent of YS. No failures occurred at 50 percent of YS in the stress-relieved specimens which indicates a beneficial effect of the stress relief on the SCC resistance of these welds. The stress relief also had a positive effect on the mechanical properties of the welds (the most important being an increase of 21 percent on the YS). Under the conditions of these tests, the straight polarity plasma are welded HP 9Ni4Co-0.30C steel plate was found highly susceptible to SCC in the nonstress-relieved condition. This susceptibility to SCC was reduced by stress relieving.

Spectral/ hp element methods: Recent developments, applications, and perspectives

NASA Astrophysics Data System (ADS)

Xu, Hui; Cantwell, Chris D.; Monteserin, Carlos; Eskilsson, Claes; Engsig-Karup, Allan P.; Sherwin, Spencer J.

2018-02-01

The spectral/ hp element method combines the geometric flexibility of the classical h-type finite element technique with the desirable numerical properties of spectral methods, employing high-degree piecewise polynomial basis functions on coarse finite element-type meshes. The spatial approximation is based upon orthogonal polynomials, such as Legendre or Chebychev polynomials, modified to accommodate a C 0 - continuous expansion. Computationally and theoretically, by increasing the polynomial order p, high-precision solutions and fast convergence can be obtained and, in particular, under certain regularity assumptions an exponential reduction in approximation error between numerical and exact solutions can be achieved. This method has now been applied in many simulation studies of both fundamental and practical engineering flows. This paper briefly describes the formulation of the spectral/ hp element method and provides an overview of its application to computational fluid dynamics. In particular, it focuses on the use of the spectral/ hp element method in transitional flows and ocean engineering. Finally, some of the major challenges to be overcome in order to use the spectral/ hp element method in more complex science and engineering applications are discussed.

Are Drivers' Manuals Right for Reluctant Readers?

ERIC Educational Resources Information Center

Stahl, Norman A.; And Others

Readability formulas were applied to the drivers' manuals of each of the 50 United States and Puerto Rico to determine whether the manuals were appropriate materials for motivating reluctant or low achieving adolescent readers. Four 100-word samples were chosen from each manual, according to four themes common to each manual and of particular…

46 CFR 12.611 - Requirements to qualify for an STCW endorsement as electro-technical rating (ETR) on vessels...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Requirements to qualify for an STCW endorsement as electro-technical rating (ETR) on vessels powered by main propulsion machinery of 750 kW/1,000 HP or more... propulsion machinery of 750 kW/1,000 HP or more. (a) To qualify for an STCW endorsement as an electro...

Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung

PubMed Central

2012-01-01

Abstract Since the existence of pHp was demonstrated, it has been shown that this molecule and its receptor CD163 are regulated by different stimuli. Furthermore, a comparably fast secretion of pHp was described as well as the immuno-stimulatory effects. The intention of this study was to elucidate the role of pHp in the human lungs further. Here we show, by means of confocal microscopy and immune-electron-microscopy, a clear co-localization of pHp with Surfactant protein-B in lamellar bodies of Alveolar Epithelial Cells Type II. These results are underlined by immunohistochemical stainings in differently fixed human lung tissues, which show pHp in vesicular and released form. The images of the released form resemble the intended position of surfactant in the human alveolus. pHp is secreted by Alveolar epithelial cells type II as previously shown. Moreover, pHp is co-localized with Surfactant protein-B. We conclude that the presented data shows that pHp is a native part of the surfactant system in the human lung. Virtual slides http://www.diagnosticpathology.diagnomx.eu/vs/2563584738239912. PMID:23164167

Local Technical Assistance Program Field Manual

DOT National Transportation Integrated Search

1997-02-01

The FHWA Local Technical Assistance Program (LTAP) provides technology transfer products to local highway departments. One of the most valuable and well-received resources of the program, the LTAP (or T 2 ) centers, have proven themselves invaluable ...

Molecular modeling and cytotoxicity of diffractaic acid: HP-β-CD inclusion complex encapsulated in microspheres.

PubMed

Silva, Camilla V N S; Barbosa, Jéssica A P; Ferraz, Milena S; Silva, Nicácio H; Honda, Neli K; Rabello, Marcelo M; Hernandes, Marcelo Z; Bezerra, Beatriz P; Cavalcanti, Isabella M F; Ayala, Alejandro P; Santos, Noemia P S; Santos-Magalhães, Nereide S

2016-11-01

In this pioneer study, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) was used to improve the solubility of the diffractaic acid (DA) via inclusion complex (DA:HP-β-CD). Subsequently, DA:HP-β-CD was incorporated into poly-ε-caprolactone (PCL) microspheres (DA:HP-β-CD-MS). Microspheres containing DA (DA-MS) or DA:HP-β-CD (DA:HP-β-CD-MS) were prepared using the multiple W/O/W emulsion-solvent evaporation technique. The phase-solubility diagram of DA in HP-β-CD (10-50mM) showed an A L type curve with a stability constant K 1:1 =821M -1 . 1 H NMR, FTIR, X-ray diffraction and thermal analysis showed changes in the molecular environment of DA in DA:HP-β-CD. The molecular modeling approach suggests a guest-host complex formation between the carboxylic moiety of both DA and the host (HP-β-CD). The mean particle size of the microspheres were ∅ DA-MS =5.23±1.65μm and ∅ DA:HP-β-CD-MS =4.11±1.39μm, respectively. The zeta potential values of the microspheres were ζ DA-MS =-7.85±0.32mV and ζ DA:HP-β-CD-MS =-6.93±0.46mV. Moreover, the encapsulation of DA:HP-β-CD into microspheres resulted in a more slower release (k 2 =0.042±0.001; r 2 =0.996) when compared with DA-MS (k 2 =0.183±0.005; r 2 =0.996). The encapsulation of DA or DA:HP-β-CD into microspheres reduced the cytotoxicity of DA (IC 50 =43.29μM) against Vero cells (IC 50 of DA-MS=108.48μM and IC 50 of DA:HP-β-CD-MS=142.63μM). Copyright © 2016 Elsevier B.V. All rights reserved.

Manual of an Instructional Program in Dental Assisting.

ERIC Educational Resources Information Center

Gilbert, Maud R., Ed.; Fiedler, Belle, Ed.

This manual is for administrator and teacher use in planning a program and individual courses for adults in dental assisting in vocational, technical, and adult programs. The manual was developed by a supervisor, a teacher-coordinator, teachers, and dentists at the local level and tested in the local school. The objectives are to prepare…

A trajectory generation and system characterization model for cislunar low-thrust spacecraft. Volume 2: Technical manual

NASA Technical Reports Server (NTRS)

Korsmeyer, David J.; Pinon, Elfego, III; Oconnor, Brendan M.; Bilby, Curt R.

1990-01-01

The documentation of the Trajectory Generation and System Characterization Model for the Cislunar Low-Thrust Spacecraft is presented in Technical and User's Manuals. The system characteristics and trajectories of low thrust nuclear electric propulsion spacecraft can be generated through the use of multiple system technology models coupled with a high fidelity trajectory generation routine. The Earth to Moon trajectories utilize near Earth orbital plane alignment, midcourse control dependent upon the spacecraft's Jacobian constant, and capture to target orbit utilizing velocity matching algorithms. The trajectory generation is performed in a perturbed two-body equinoctial formulation and the restricted three-body formulation. A single control is determined by the user for the interactive midcourse portion of the trajectory. The full spacecraft system characteristics and trajectory are provided as output.

The transport kinetics and selectivity of HpUreI, the urea channel from Helicobacter pylori†

PubMed Central

Gray, Lawrence R; Gu, Sean X; Quick, Matthias; Khademi, Shahram

2017-01-01

Helicobacter pylori’s unique ability to colonize and survive in the acidic environment of the stomach is critically dependent on uptake of urea through the urea channel, HpUreI. Hence, HpUreI may represent a promising target for the development of specific drugs against this human pathogen. To obtain insight into the structure/function relationship of this channel, we have developed conditions for the high-yield expression and purification of stable recombinant HpUreI that allowed its detailed kinetic characterization in solubilized form and reconstituted into liposomes. Detergent-solubilized HpUreI forms homo-trimer, as determined by chemical cross-linking. Urea dissociation kinetics of purified HpUreI were determined by means of the scintillation proximity assay (SPA), whereas urea efflux was measured in HpUreI-containing proteoliposomes using stopped-flow spectrometry to determine the kinetics and selectivity of the urea channel. The kinetic analyses revealed that urea conduction in HpUreI is pH sensitive and saturable with a half-saturation concentration (or K0.5) of ~163 mM. Binding of urea by HpUreI was increased at lower pH; however, the apparent affinity of urea binding (~150 mM) was not significantly pH dependent. The solute selectivity analysis indicated that HpUreI is highly selective for urea and hydroxyurea. Removing either amino group of urea molecules diminishes their permeability through HpUreI. Similar to urea conduction, water diffusion through HpUreI is pH-dependent with low water permeability at neutral pH. PMID:21877689

Higher Education Finance Manual. Technical Report No. 53. Field Review Edition.

ERIC Educational Resources Information Center

Collier, Douglas J.

The primary goal of the Higher Education Finance Manual project is to assist in higher education decisionmaking as it relates to the need for and the use of financial information. The objectives of this manual are to: (1) provide uniform definitions and procedures for displaying and reporting those financial data used most often in higher…

Guidance Manual: Asbestos Operations & Maintenance Work Practices. Second Edition.

ERIC Educational Resources Information Center

National Inst. of Building Sciences, Washington, DC.

This technical manual provides detailed guidance to building owners, asbestos program managers, and operations and maintenance (O&M) workers for managing asbestos-containing materials (ACM) in buildings. The manual addresses four different types of ACM found in buildings and three different levels of precaution which may be warranted by…

CDPOP Users Manual

Treesearch

E. L. Landguth; B. K. Hand; J. M. Glassy; S. A. Cushman; M. Jacobi; T. J. Julian

2011-01-01

The goal of this user manual is to explain the technical aspects of the current release of the CDPOP program. CDPOP v1.0 is a major extension of the CDPOP program (Landguth and Cushman 2010). CDPOP is an individual-based program that simulates the influences of landscape structure on emergence of spatial patterns in population genetic data as functions of individual-...

Computing Gross Pay from Punched Time Cards. Student Manual and Instructor's Manual.

ERIC Educational Resources Information Center

McElveen, Peggy C.

Supporting performance objective 30 of the V-TECS (Vocational-Technical Education Consortium of States) Secretarial Catalog, both a set of student materials and an instructor's manual on computing gross pay from punched time cards are included in this packet, which is part of a series. The student materials include a group of time cards,…

Sanitary Survey Training. The Need-to-Know Material. Instructor's Technical Manual.

ERIC Educational Resources Information Center

Gardner, Anne, Ed.

This manual, developed as an aid to state agencies who provide instruction to inspectors of water systems, is based on the minimum information that an inspector with limited experience needs to know to successfully assess a public water system. The manual is designed for use by individuals who are experts in the field of water systems and sanitary…

Monocrotophos, an organophosphorus insecticide, disrupts the expression of HpNetrin and its receptor neogenin during early development in the sea urchin (Hemicentrotus pulcherrimus).

PubMed

Zhang, Xiaona; Xu, Lei; Tian, Hua; Wang, Cuicui; Wang, Wei; Ru, Shaoguo

2017-09-01

Netrins, chemotropic guidance cues, can guide the extension of serotonergic axons by binding to netrin receptors during neural development. However, little is known about whether disruption of netrin signaling is involved in the mechanisms by which organophosphorus pesticides affect serotonergic nervous system (SNS) development. In this study, we evaluated the effects of the pesticide monocrotophos (MCP) on the expression patterns of HpNetrin and its receptor neogenin as well as on the intracellular calcium ion (Ca 2+ ) levels in Hemicentrotus pulcherrimus (sea urchin) by exposing fertilized embryos to 0, 0.01, 0.10, and 1.00mg/L MCP. The results showed that MCP disrupted HpNetrin and neogenin expression at different developmental stages in H. pulcherrimus and that Ca 2+ appeared to be involved in the MCP-induced developmental neurotoxicity. Specifically, the lower concentrations of MCP elevated HpNetrin and neogenin transcription, resulting in higher intracellular Ca 2+ levels during the early developmental stages in the sea urchin; this may affect netrin-directed cell migration/axon extension and subsequently disrupt serotonergic axon branching and synapse formation. In contrast, 1.00mg/L MCP exhibited an inhibitory effect on HpNetrin and neogenin transcription. This finding implies that the regulatory roles of these factors may be diminished during early development, thereby causing developmental defects in the sea urchin. Collectively, our results provide a basis for exploring the involvement of netrin and neogenin in the organophosphate-induced disruption of the SNS during development. Copyright © 2017 Elsevier B.V. All rights reserved.

Effect of Mutations on HP Lattice Proteins

NASA Astrophysics Data System (ADS)

Shi, Guangjie; Vogel, Thomas; Landau, David; Li, Ying; Wüst, Thomas

2013-03-01

Using Wang-Landau sampling with approriate trial moves[2], we investigate the effect of different types of mutations on lattice proteins in the HP model. While exact studies have been carried out for short HP proteins[3], the systems we investigate are of much larger size and hence not accessible for exact enumerations. Based on the estimated density of states, we systematically analyse the changes in structure and degeneracy of ground states of particular proteins and measure thermodynamic quantities like the stability of ground states and the specific heat, for example. Both, neutral mutations, which do not change the structure and stability of ground states, as well as critical mutations, which do change the thermodynamic behavior qualitatively, have been observed. Research supported by NSF

Lost and Found

Science.gov Websites

Packard Operating Manual HP-IB System DC Power Supplies HP Models 6632A, 6633A, 6634A National Instruments LabView2 User Manual (Jan 1993 Edition) Hewlett Packard Operating and Service Manual HP-IB Isolated DAC

Preparing Payroll Register, Employee Earnings' Records, and Paychecks. Student's Manual and Instructor's Manual.

ERIC Educational Resources Information Center

McElveen, Peggy C.

Supporting performance objective 28 of the V-TECS (Vocational-Technical Education Consortium of States) Secretarial Catalog, both a set of student materials and an instructor's manual on preparing a payroll register, employee earnings' records, and paychecks are included in this packet, which is one in a series. The student materials include a…

Testing of YUH-61A helicopter transmission in NASA Lewis 2240-kW (3000-hp facility

NASA Technical Reports Server (NTRS)

Mitchell, A. M.; Oswald, F. B.; Schuller, F. T.

1986-01-01

A helicopter transmission that was being considered for the Army's Utility Tactical Transport Attack System (UTTAS) was tested in the NASA Lewis 2240-kW (3000-hp) test facility to obtain the transmission's operational data. The results will form a vibration and efficiency data base for evaluation similar-class helicopter transmissions. The transmission's mechanical efficiency was determined to be 98.7 percent at its rated power level of 2080 kW (2792 hp). At power levels up to 113 percent of rated the transmission displayed 56 percent higher vibration acceleration levels on the right input than on the left input. Both vibration signature analysis and final visual inspection indicated that the right input spiral-bevel gear had poor contact patterns. The highest vibration meter level was 52 g's rms at the accessory gear, which had free-wheeling gearsets. At 113 percent power and 100 percent rated speed the vibration meter levels generally ranged from 3 to 25 g's rms.

The CompHP Core Competencies Framework for Health Promotion in Europe

ERIC Educational Resources Information Center

Barry, Margaret M.; Battel-Kirk, Barbara; Dempsey, Colette

2012-01-01

Background: The CompHP Project on Developing Competencies and Professional Standards for Health Promotion in Europe was developed in response to the need for new and changing health promotion competencies to address health challenges. This article presents the process of developing the CompHP Core Competencies Framework for Health Promotion across…

Metric Supplement to Technical Drawing.

ERIC Educational Resources Information Center

Henschel, Mark

This manual is intended for use in training persons whose vocations involve technical drawing to use the metric system of measurement. It could be used in a short course designed for that purpose or for individual study. The manual begins with a brief discussion of the rationale for conversion to the metric system. It then provides a…

A prescribed wake rotor inflow and flow field prediction analysis, user's manual and technical approach

NASA Technical Reports Server (NTRS)

Egolf, T. A.; Landgrebe, A. J.

1982-01-01

A user's manual is provided which includes the technical approach for the Prescribed Wake Rotor Inflow and Flow Field Prediction Analysis. The analysis is used to provide the rotor wake induced velocities at the rotor blades for use in blade airloads and response analyses and to provide induced velocities at arbitrary field points such as at a tail surface. This analysis calculates the distribution of rotor wake induced velocities based on a prescribed wake model. Section operating conditions are prescribed from blade motion and controls determined by a separate blade response analysis. The analysis represents each blade by a segmented lifting line, and the rotor wake by discrete segmented trailing vortex filaments. Blade loading and circulation distributions are calculated based on blade element strip theory including the local induced velocity predicted by the numerical integration of the Biot-Savart Law applied to the vortex wake model.

HP-41CX Programs for HgCdTe Detectors and IR Systems.

DTIC Science & Technology

1987-10-01

FIELD GROUP SUB-GROUP IPocket Computer HgCdTe PhotoSensor Programs Detectors Analysis I I l-IP-41 Infrared IR Systems __________ 19 ABSTRACT (Continue... HgCdTe detectors , focal planes, and infrared systems. They have been written to run in a basic HP-41CV or HP-41CX with no card reader or additional ROMs...Programs have been written for the HP-41CX which aid in the analysis of HgCdTe detectors , focal r planes, and infrared systems. They have been installed as a

Testing of UH-60A helicopter transmission in NASA Lewis 2240-kW (3000-hp) facility

NASA Technical Reports Server (NTRS)

Mitchell, A. M.; Oswald, F. B.; Coe, H. H.

1986-01-01

The U.S. Army's UH-60A Black Hawk 2240-kW (3000-hp) class, twin-engine helicopter transmission was tested at the NASA Lewis Research Center. The vibration and efficiency test results will be used to enhance the data base for similar-class helicopters. Most of the data were obtained for a matrix of test conditions of 50 to 100 percent of rated rotor speed and 20 to 100 percent of rated input power. The transmission's mechanical efficiency at 100 percent of rated power was 97.3 and 97.5 percent with its inlet oil maintained at 355 and 372 K (180 and 210 F), respectively. The highest vibration reading was 72 g's rms at the upper housing side wall. Other vibration levels measured near the gear meshes are reported.

A Comparison of Robotically Assisted Microsurgery versus Manual Microsurgery in Challenging Situations.

PubMed

Willems, Joost I P; Shin, Alexandra M; Shin, Delaney M; Bishop, Allen T; Shin, Alexander Y

2016-04-01

Microsurgery can be challenging secondary to orientation of the vessels, accessibility, or depth of the wound. Robotically assisted microsurgery reduces tremors and improves visualization and may improve the quality of anastomosis compared with traditional microsurgery. The purpose of this study was to compare robotically assisted microsurgery to traditional microsurgery in technically challenging situations with respect to time of anastomosis, quality of anastomosis, and Objective Structured Assessment of Technical Skills. Two investigators with no prior surgery or microsurgery experience performed 160 anastomoses on artificial microvessels after undergoing standardized traditional and robotically assisted microsurgery courses. Five different exposure groups were created with depths of 0, 10, and 20 cm and sidewall angles of 20 and 30 degrees. A comparison of 80 manual with 80 robotically assisted microsurgery anastomoses in different exposure groups was undertaken. The modified Objective Structured Assessment of Technical Skills scoring system, duration per anastomosis, and a subjective comfort scale were evaluated. In the most difficult exposure, Objective Structured Assessment of Technical Skills scores were similar in both groups (p = 0.98), the duration was higher in the manual group (p = 0.004), and the subjective comfort rating was higher in the robotically assisted microsurgery group (p < 0.001). In the easiest (0-cm depth, flat) exposure, Objective Structured Assessment of Technical Skills scores were higher in the manual group (p = 0.018) and the duration was longer in the robotically assisted microsurgery group (p = 0.008). Manual surgery was superior to robotically assisted microsurgery in technically easy exposures. In difficult exposures (greater depth and lower sidewall angles), however, robotically assisted microsurgery had a shorter surgery time and a higher comfort rating, with Objective Structured Assessment of Technical Skills scores similar to

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.

PubMed

Osbourn, Megan; Soares, Dinesh C; Vacca, Francesco; Cohen, E Suzanne; Scott, Ian C; Gregory, William F; Smyth, Danielle J; Toivakka, Matilda; Kemter, Andrea M; le Bihan, Thierry; Wear, Martin; Hoving, Dennis; Filbey, Kara J; Hewitson, James P; Henderson, Holly; Gonzàlez-Cìscar, Andrea; Errington, Claire; Vermeren, Sonja; Astier, Anne L; Wallace, William A; Schwarze, Jürgen; Ivens, Alasdair C; Maizels, Rick M; McSorley, Henry J

2017-10-17

Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. Here, we identified H. polygyrus Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, containing three predicted complement control protein (CCP) modules. In vivo, recombinant HpARI abrogated IL-33, group 2 innate lymphoid cell (ILC2) and eosinophilic responses to Alternaria allergen administration, and diminished eosinophilic responses to Nippostrongylus brasiliensis, increasing parasite burden. HpARI bound directly to both mouse and human IL-33 (in the cytokine's activated state) and also to nuclear DNA via its N-terminal CCP module pair (CCP1/2), tethering active IL-33 within necrotic cells, preventing its release, and forestalling initiation of type 2 allergic responses. Thus, HpARI employs a novel molecular strategy to suppress type 2 immunity in both infection and allergy. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Photodynamic therapy of endometriosis with HpD (Photosan III) in a new in vitro model

NASA Astrophysics Data System (ADS)

Viereck, Volker; Werter, Wiebke; Rueck, Angelika C.; Steiner, Rudolf W.; Keckstein, J.

1994-07-01

As a new treatment model for endometriosis, photodynamic therapy was applied to endometriotic and endometrial cultures. It could be demonstrated that both endometrial components (epithelium and stroma) were present in the cultures, proved by immunocytology and electron microscopy. No major differences were seen between endometriotic and endometrial cells. The cultures were treated by HpD-sensitized PDT. Incubation time was 24 h and concentrations of 5 and 10 (mu) g/ml were used. Irradiation was performed by an argon-pumped dye laser at 630 nm with a power density of 80 mW/cm2. Evaluation both morphologically and by trypan blue exclusion test, was effected 24 h after irradiation. Toxicity in endometriotic and endometrial cultures was practically identical. Stroma cells were more sensitive to photodynamic treatment than epithelial cells. Complete stromal cell destruction was reached at 15 J/cm2, whereas epithelial cells showed 100 lethality at 40 J/cm2 (10(mu) g/ml HpD). These and subsequent results demonstrate that the sensitivity of stromal cells was about seven times higher than that of epithelial cells.

Coordinating and Performing Activities for Employer. Preparing Expense Reports. Student Manual and Teacher's Manual.

ERIC Educational Resources Information Center

Jones, Maleeta M.

Supporting performance objective 13 of the V-TECS (Vocational-Technical Education Consortium of States) Secretarial Catalog, both a set of student materials and an instructor's manual on preparing employer's business expense statements are included in this packet. (The packet is the fourth in a set of four on coordinating and performing activities…

Computing LORAN time differences with an HP-25 hand calculator

NASA Technical Reports Server (NTRS)

Jones, E. D.

1978-01-01

A program for an HP-25 or HP-25C hand calculator that will calculate accurate LORAN-C time differences is described and presented. The program is most useful when checking the accuracy of a LORAN-C receiver at a known latitude and longitude without the aid of an expensive computer. It can thus be used to compute time differences for known landmarks or waypoints to predict in advance the approximate readings during a navigation mission.

Theoretical study on the polar hydrogen-π (Hp-π) interactions between protein side chains

PubMed Central

2013-01-01

Background In the study of biomolecular structures and interactions the polar hydrogen-π bonds (Hp-π) are an extensive molecular interaction type. In proteins 11 of 20 natural amino acids and in DNA (or RNA) all four nucleic acids are involved in this type interaction. Results The Hp-π in proteins are studied using high level QM method CCSD/6-311 + G(d,p) + H-Bq (ghost hydrogen basis functions) in vacuum and in solutions (water, acetonitrile, and cyclohexane). Three quantum chemical methods (B3LYP, CCSD, and CCSD(T)) and three basis sets (6-311 + G(d,p), TZVP, and cc-pVTZ) are compared. The Hp-π donors include R2NH, RNH2, ROH, and C6H5OH; and the acceptors are aromatic amino acids, peptide bond unit, and small conjugate π-groups. The Hp-π interaction energies of four amino acid pairs (Ser-Phe, Lys-Phe, His-Phe, and Tyr-Phe) are quantitatively calculated. Conclusions Five conclusion points are abstracted from the calculation results. (1) The common DFT method B3LYP fails in describing the Hp-π interactions. On the other hand, CCSD/6-311 + G(d,p) plus ghost atom H-Bq can yield better results, very close to the state-of-the-art method CCSD(T)/cc-pVTZ. (2) The Hp-π interactions are point to π-plane interactions, possessing much more interaction conformations and broader energy range than other interaction types, such as common hydrogen bond and electrostatic interactions. (3) In proteins the Hp-π interaction energies are in the range 10 to 30 kJ/mol, comparable or even larger than common hydrogen bond interactions. (4) The bond length of Hp-π interactions are in the region from 2.30 to 3.00 Å at the perpendicular direction to the π-plane, much longer than the common hydrogen bonds (~1.9 Å). (5) Like common hydrogen bond interactions, the Hp-π interactions are less affected by solvation effects. PMID:23705926

Nursery Production, A Teacher's Manual.

ERIC Educational Resources Information Center

Buckey, Sylvia; And Others

Developed by a group of university faculty members and graduate assistants, this planning guide is designed for teachers' use in high school, technical school, and associate degree agriculture programs in teaching nursery production with the focus on entry and advanced level occupations. This manual consists of the text of the student handbook…

Manual Training Schools in America.

ERIC Educational Resources Information Center

Schenck, John P.

John Runkle, president of the Massachusetts Institute of Technology (MIT), viewed the Moscow Imperial Technical School exhibit at the Philadelphia Centennial Exposition of 1876 and saw the Russian method of manual training as the answer to the dilemma of combining theory and practice in engineering instruction. On August 17, 1876, shops in which…

Efficacy of plaque removal and learning effect of a powered and a manual toothbrush.

PubMed

Lazarescu, D; Boccaneala, S; Illiescu, A; De Boever, J A

2003-08-01

Subjects with high plaque and gingivitis scores can profit most from the introduction of new manual or powered tooth brushes. To improve their hygiene, not only the technical characteristics of new brushes but also the learning effect in efficient handling are of importance. : The present study compared the efficacy in plaque removal of an electric and a manual toothbrush in a general population and analysed the learning effect in efficient handling. Eighty healthy subjects, unfamiliar with electric brushes, were divided into two groups: group 1 used the Philips/Jordan HP 735 powered brush and group 2 used a manual brush, Oral-B40+. Plaque index (PI) and gingival bleeding index (GBI) were assessed at baseline and at weeks 3, 6, 12 and 18. After each evaluation, patients abstained from oral hygiene for 24 h. The next day a 3-min supervised brushing was performed. Before and after this brushing, PI was assessed for the estimation of the individual learning effect. The study was single blinded. Over the 18-week period, PI reduced gradually and statistically significantly (p<0.001) in group 1 from 2.9 (+/-0.38) to 1.5 (+/-0.24) and in group 2 from 2.9 (+/-0.34) to 2.2 (+/-0.23). From week 3 onwards, the difference between groups was statistically significant (p<0.001). The bleeding index decreased in group 1 from 28% (+/-17%) to 7% (+/-5%) (p<0.001) and in group 2 from 30% (+/-12%) to 12% (+/-6%) (p<0.001). The difference between groups was statistically significant (p<0.001) from week 6 onwards. The learning effect, expressed as the percentage of plaque reduction after 3 min of supervised brushing, was 33% for group 1 and 26% for group 2 at week 0. This percentage increased at week 18 to 64% in group 1 and 44% in group 2 (difference between groups statistically significant: p<0.001). The powered brush was significantly more efficient in removing plaque and improving gingival health than the manual brush in the group of subjects unfamiliar with electric brushes. There

Stationary Engineering Laboratory Manual--2.

ERIC Educational Resources Information Center

Steingress, Frederick M.; Frost, Harold J.

The Stationary Engineering Laboratory Manual 2 was designed for vocational/technical high school students who have received instruction in the basics of stationary engineering. It was developed for students who will be operating a live plant and who will be responsible for supplying steam for heating, cooking, and baking. Each lesson in the manual…

R&D 100 Awards | NREL

Science.gov Websites

a cost of about $.50/watt. Learn more HP Apollo 8000 System HP Apollo 8000 System Uses component Award - HP Apollo 8000 System - Steve Hammond and Team 2008 Editor's Choice Award - Hybrid CIGS (copper

HP-41CV Flight Performance Advisory System (FPAS) for the E-2C, E-2B, and C-2A Aircraft

DTIC Science & Technology

1982-06-01

NPS67-82- 003 NAVAL POSTGRADUATE SCHOOL Monterey, California DTIC HP-41CV FLIGHT PERFORMANCE ADVISORY SYSTEM (FPAS) FOR THE E-2C, E-2B, AND C-2A...A’P-𔃻"’f .00 ____________ 4. TITLE9 (and Subtil) SL TYPE OF REPORT & PERIOD COVERED H1P-41CV FLIGHT PERFORMANCE ADVISORY SYSTEM (FPAS) TECHNICAL REPORT...complement the original design of a Flight Performance Advisory System (FPAS) for the E-2C aircraft. The original design fulfilled the requirements of AE 3001

ILGWU Worker-Family Education Program. ESL/Technical Curriculum Manual.

ERIC Educational Resources Information Center

Friedman, Judy; Friedman, Deidre

The curriculum for the International Ladies' Garment Workers' Union (ILGWU) English as a Second Language (ESL) and technical classes is a collection of instructional materials and suggestions focusing on workplace-related topics and issues. This guide is intended for use in classes where one technical and one ESL teacher are present and where…

U.S. Department of Energy Vehicle Technologies Program: Battery Test Manual For Plug-In Hybrid Electric Vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Christophersen, Jon P.

2014-09-01

This battery test procedure manual was prepared for the United States Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Vehicle Technologies Office. It is based on technical targets for commercial viability established for energy storage development projects aimed at meeting system level DOE goals for Plug-in Hybrid Electric Vehicles (PHEV). The specific procedures defined in this manual support the performance and life characterization of advanced battery devices under development for PHEV’s. However, it does share some methods described in the previously published battery test manual for power-assist hybrid electric vehicles. Due to the complexity of somemore » of the procedures and supporting analysis, future revisions including some modifications and clarifications of these procedures are expected. As in previous battery and capacitor test manuals, this version of the manual defines testing methods for full-size battery systems, along with provisions for scaling these tests for modules, cells or other subscale level devices. The DOE-United States Advanced Battery Consortium (USABC), Technical Advisory Committee (TAC) supported the development of the manual. Technical Team points of contact responsible for its development and revision are Renata M. Arsenault of Ford Motor Company and Jon P. Christophersen of the Idaho National Laboratory. The development of this manual was funded by the Unites States Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Technical direction from DOE was provided by David Howell, Energy Storage R&D Manager and Hybrid Electric Systems Team Leader. Comments and questions regarding the manual should be directed to Jon P. Christophersen at the Idaho National Laboratory (jon.christophersen@inl.gov).« less

Reciprocal contribution of clinical studies and the HP10 antigen ELISA for the diagnosis of extraparenchymal neurocysticercosis.

PubMed

Parkhouse, R Michael E; Carpio, Arturo; Campoverde, Alfredo; Sastre, Patricia; Rojas, Glenda; Cortez, María Milagros

2018-02-01

To evaluate diagnosis of active neurocysticercosis, paired cerebral spinal fluid (CSF) and serum samples from 24 neurocysticercosis (NCC) patients and 17 control neurological patients were assayed in the HP10 Taenia antigen (Ag) ELISA. The CSF samples were also tested with an HP10 Lateral Flow Assay (LFA). The HP10 Ag was detected by ELISA in the CSF of 5/5 patients with Definitive extraparenchymal NCC, and in 4/5 of the corresponding sera. In the Definitive parenchymal group, on the other hand, the HP10 Ag was absent in 2/3 CSF (with a very low value in the one positive sample) and all the corresponding serum samples. Samples of CSF from 4/7 patients in the Probable parenchymal group, were also significantly HP10 Ag positive, suggesting the presence of extraparenchymal cysts not identified by the imaging studies. With the possible exception of one patient, the corresponding serum samples of the Probable parenchymal NCC group, were all HP10 Ag negative. Samples of CSF from 9 NCC patients diagnosed with Mixed parenchymal and extraparenchymal NCC were all significantly HP10 Ag positive, confirming the presence of extraparenchymal cysts, with only 7/9 of the corresponding serum samples being HP10 positive. Thus detection of the HP10 Ag indicates extraparenchymal and not parenchymal cyst localization and is more sensitive with CSF than serum. Three neurological patients clinically diagnosed as subarachnoid cyst, hydrocephalus and tuberculoma, respectively, were clearly positive for HP10 Ag. Of these, two were confirmed as NCC by subsequent imaging; the third died prior to further examination. Thus, a total of 8 patients had their clinical diagnosis questioned. Finally, there was good agreement between the HP10 Ag ELISA and LFA with CSF samples giving an optical density ≥0.4 in the ELISA assay. In conclusion, the HP10 Ag assay should provide a valuable and reciprocal tool in the clinical diagnosis and follow up of extraparenchymal NCC. Copyright © 2017 Elsevier B

General Principles for Manual/Simultaneous Communication (M/SC) Instruction.

ERIC Educational Resources Information Center

Caccamise, Frank; And Others

1978-01-01

The article discusses principles in use at the National Technical Institute for the Deaf in planning and implementing Manual/Simultaneous Communication instruction for hearing impaired and deaf individuals. (PHR)

NPDES Permit Writers' Manual for Concentrated Animal Feeding Operations

EPA Pesticide Factsheets

This manual is designed to provide general information on the CWA and NPDES requirements for CAFOs, explain CAFO permitting, and provide technical information to understand options for nutrients management planning.

Pneumatics. Student's Manual [and] Instructor's Guide.

ERIC Educational Resources Information Center

Notgrass, Troy

The student's manual in this two-part instructional kit is designed to help the following types of students learn introductory technical material related to pneumatics: (1) groups of trade and industrial students with a variety of vocational objectives and (2) homogeneous groups in which the learning levels of individual students vary…

Cost effectiveness in Canada of a multidrug prepackaged regimen (Hp-PAC)+ for Helicobacter pylori eradication.

PubMed

Agro, K; Blackhouse, G; Goeree, R; Willan, A R; Huang, J Q; Hunt, R H; O'Brien, B J

2001-01-01

To assess the cost effectiveness of a multidrug prepackaged regimen for Helicobacter pylori, the Hp-PAC (lansoprazole 30mg, clarithromycin 500 mg, amoxicillin 1 g, all twice daily), relative to alternative pharmacological strategies in the management of confirmed duodenal ulcer over a 1-year period from 2 perspectives: (i) a strict healthcare payer perspective (Ontario Ministry of Health) excluding the patient copayment; and (ii) a healthcare payer perspective including the patient copayment. A decision-analytical model was developed to estimate expected per patient costs [1998 Canadian dollars ($ Can)], weeks without ulcer and symptomatic ulcer recurrences for the Hp-PAC compared with: proton pump inhibitor (PPI)-clarithromycin-amoxicillin (PPI-CA), PPI-clarithromycin-metronidazole (PPI-CM), PPI-amoxicillin-metronidazole (PPI-AM) and ranitidine-bismuthmetronidazole-tetracycline (RAN-BMT). All PPI-based regimens had higher expected costs but better outcomes relative to RAN-BMT. From a strict healthcare payer perspective, PPI-CM ($Can 209) yielded lower expected costs than PPI-CA ($Can 221) and slightly lower costs than Hp-PAC ($Can 211). However, these 3 regimens all shared identical outcomes (51.2 weeks without ulcer). When the current Ontario, Canada, $Can 2 patient copayment was added to the dispensing fee, Hp-PAC yielded lower costs ($Can 214) than PPI-CM ($Can 216). From a strict healthcare payer perspective, Hp-PAC is weakly dominated by PPI-CM with an incremental cost effectiveness (relative to RAN-BMT) of $Can 5.77 per ulcer week averted. When the patient copayment is added to this perspective, Hp-PAC weakly dominates PPI-CM ($Can 5 per ulcer week averted). Regardless of perspective, Hp-PAC and PPI-CM differed by only $Can 2 per patient over 1 year and the expected time without ulcer was 51.2 weeks for both. More data on the clinical and statistical differences in H. pylori eradication with Hp-PAC and PPI-CM would be useful. This analysis does not in clude

Industrial Maintenance Technology (IM-TEC). Student Manual.

ERIC Educational Resources Information Center

Fusch, Gene E.

This student manual explains an innovative strategy through which Bellingham Technical College's (Washington) evening Industrial Electrician and Millwright Apprenticeships were aggregated with workforce upgrade course offerings to form the college's first evening degree program in Industrial Maintenance Technology (IM-TEC). Section 1 contains a…

75 FR 28858 - Agency Information Collection (Service Data Manual) Activities Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-24

... operator's manuals and maintenance/repair manuals when technical medical equipment and devices, or... U.S.C. 3501-3521), this notice announces that the Office of Acquisition and Materiel Management... Management and Budget (OMB) for review and comment. The PRA submission describes the nature of the...

Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging.

PubMed

Neuner, Sarah M; Garfinkel, Benjamin P; Wilmott, Lynda A; Ignatowska-Jankowska, Bogna M; Citri, Ami; Orly, Joseph; Lu, Lu; Overall, Rupert W; Mulligan, Megan K; Kempermann, Gerd; Williams, Robert W; O'Connell, Kristen M S; Kaczorowski, Catherine C

2016-10-01

An individual's genetic makeup plays an important role in determining susceptibility to cognitive aging. Identifying the specific genes that contribute to cognitive aging may aid in early diagnosis of at-risk patients, as well as identify novel therapeutics targets to treat or prevent development of symptoms. Challenges to identifying these specific genes in human studies include complex genetics, difficulty in controlling environmental factors, and limited access to human brain tissue. Here, we identify Hp1bp3 as a novel modulator of cognitive aging using a genetically diverse population of mice and confirm that HP1BP3 protein levels are significantly reduced in the hippocampi of cognitively impaired elderly humans relative to cognitively intact controls. Deletion of functional Hp1bp3 in mice recapitulates memory deficits characteristic of aged impaired mice and humans, further supporting the idea that Hp1bp3 and associated molecular networks are modulators of cognitive aging. Overall, our results suggest Hp1bp3 may serve as a potential target against cognitive aging and demonstrate the utility of genetically diverse animal models for the study of complex human disease. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

DAMT - DISTRIBUTED APPLICATION MONITOR TOOL (HP9000 VERSION)

NASA Technical Reports Server (NTRS)

Keith, B.

1994-01-01

processes. The independent processes communicate with each other via UNIX sockets through a Virtual Path router, or Switcher. The Switcher maintains a routing table showing the host of each component process of the tool, eliminating the need for each process to do so. The Central Monitor Complex provides the single application program interface (API) to the user and coordinates the activities of DAMT. The Central Monitor Complex is itself divided into independent objects that perform its functions. The component objects are the Central Monitor, the Process Locator, the Circuit Locator, and the Traffic Reporter. Each of these objects is an independent, asynchronously executing process. User requests to the tool are interpreted by the Central Monitor. The Process Locator identifies whether a named process is running on a monitored host and which host that is. The circuit between any two processes in the distributed application is identified using the Circuit Locator. The Traffic Reporter handles communication with the LAN Analyzer and accumulates traffic updates until it must send a traffic report to the user. The Remote Monitor process is replicated on each monitored host. It serves the Central Monitor Complex processes with application process information. The Remote Monitor process provides access to operating systems information about currently executing processes. It allows the Process Locator to find processes and the Circuit Locator to identify circuits between processes. It also provides lifetime information about currently monitored processes. The LAN Analyzer consists of two processes. Low-level monitoring is handled by the Sniffer. The Sniffer analyzes the raw data on a single, physical LAN. It responds to commands from the Analyzer process, which maintains the interface to the Traffic Reporter and keeps track of which circuits to monitor. DAMT is written in C-language for HP-9000 series computers running HP-UX and Sun 3 and 4 series computers running SunOS. DAMT

Diagnosis of Gestational, Congenital, and Placental Malaria in Colombia: Comparison of the Efficacy of Microscopy, Nested Polymerase Chain Reaction, and Histopathology

PubMed Central

Campos, Ivón M.; Uribe, Mary L.; Cuesta, Carolina; Franco-Gallego, Alexander; Carmona-Fonseca, Jaime; Maestre, Amanda

2011-01-01

The technical capability of different methods to diagnose Plasmodium in maternal peripheral blood, placenta, and umbilical cord blood has not been assessed in Colombia and seldom explored in other malaria-endemic regions. We designed a study to compare the technical and the operational-economical performances of light microscopy (LM), nested polymerase chain reaction (nPCR), and histopathology (HP). In maternal blood, LM had 41% sensitivity and 100% specificity and in placental blood, 35% and 100%, respectively, compared with nPCR. In placental tissue, LM had 33% sensitivity and 95% specificity; and nPCR 47% and 77%, respectively; compared with HP. Light microscopy had the best operational-economical qualification. We concluded that nPCR and HP performed better compared with LM, but field implementation of these two techniques remains a problem. Therefore, LM is recommended as the gold standard for diagnosis of gestational malaria and placental blood infection in the field. PMID:21633030

IPLIB (Image processing library) user's manual

NASA Technical Reports Server (NTRS)

Faulcon, N. D.; Monteith, J. H.; Miller, K.

1985-01-01

IPLIB is a collection of HP FORTRAN 77 subroutines and functions that facilitate the use of a COMTAL image processing system driven by an HP-1000 computer. It is intended for programmers who want to use the HP 1000 to drive the COMTAL Vision One/20 system. It is assumed that the programmer knows HP 1000 FORTRAN 77 or at least one FORTRAN dialect. It is also assumed that the programmer has some familiarity with the COMTAL Vision One/20 system.

Software Manuals: Where Instructional Design and Technical Writing Join Forces.

ERIC Educational Resources Information Center

Thurston, Walter, Ed.

1986-01-01

Presents highlights from a panel discussion by well known San Francisco Bay area documentation writers, instructional designers, and human performance technologists. Three issues on user performance and documentation are addressed: whether people avoid reading user manuals and why; major human factors influencing documentation use; and…

[Relationships between the enrichment of ETBF, Fn, Hp in intestinal and colorectal cancer].

PubMed

Zhang, J; Lu, X L; Zhao, G; Shi, H T; Geng, Y; Zhong, W T; Dong, L

2018-02-23

Objective: To explore relationships between the enrichment of ETBF, Fn, Hp in feces, tissues and colorectal cancer. Methods: Feces, lesion tissue and adjacent tissue from 24 patients with colorectal cancer and 31 patients with adenomas were collected, and we collected Feces and tissue of 20 healthy control persons. Then the copy numbers of enterotoxigenic B. fragilis (ETBF), Fusobacterium nucleatum (Fn) and Helicobacter pylori (Hp) were determined by quantitative real-time PCR. Immunohistochemical method was used to examine the expression intensity of EGFR and p53, and the relationships between different expression intensity of EGFR, p53 and the numbers of three bacterias. Results: In the feces, copy numbers of ETBF and Fn were as follous: colorectal cancer group>adenomas group>healthy control group ( P <0.05). Copy numbers of Hp were as follous: colorectal cancer group>healthy control group ( P <0.01); adenomas group>healthy control group ( P <0.01). In the tissue, copy numbers of ETBF, Fn were as follows: colorectal cancer group>adenomas group>healthy control group ( P <0.05). Copy numbers of Hp were as follows: colorectal cancer group>healthy control group ( P <0.01); adenomas group>healthy control group ( P <0.01). Copy numbers of those three bacteria in the lesion tissue and the adjacent tissue had no significant difference. This happened both in colorectal cancer group and adenomas group. The different expression intensity of EGFR, p53 and the number of three bacteria showed no obviously statistical correlation( P >0.05). Conclusion: Adenomatous polyp and colorectal cancer patients show high enrichment of ETBF, Fn and Hp in both feces and tissues. ETBF, Fn and Hp probably contribute to the development of adenomatous polyp and colorectal cancer. Trial registration Chinese Clinical Trial Registry, ChiCTR-BOC-17012509.

An Overview of Clarkson's Technical Communications Program.

ERIC Educational Resources Information Center

Barkman, Patricia R.

The technical communications program at Clarkson College (New York) offers students 23 courses in subjects ranging from interpersonal behavior to engineering and scientific report writing to computer documentation and the development of technical manuals. With the help of an advisor, each student works out a course of study appropriate to his or…

Opticalman 1 and C, Rate Training Manual.

ERIC Educational Resources Information Center

Naval Personnel Program Support Activity, Washington, DC.

The technical subject matter of this rate training manual is written for regular navy and naval reserve personnel. Responsibilities for optical shop administration, supervision, and training are discussed in detail. Metals are studied in connection with heat treating processes. Characteristics of light are analyzed to familiarize students with…

APTI Course 427, Combustion Evaluation. Student Manual.

ERIC Educational Resources Information Center

Beard, J. Taylor; And Others

This student manual supplements a course designed to present fundamental and applied aspects of combustion technology which influence air pollutant emissions. Emphasis is placed on process control of combustion rather than on gas cleaning. The course is intended to provide engineers, regulatory and technical personnel, and others with familiarity…

Kepler Archive Manual

NASA Technical Reports Server (NTRS)

Thompson, Susan E.; Fraquelli, Dorothy; Van Cleve, Jeffrey E.; Caldwell, Douglas A.

2016-01-01

A description of Kepler, its design, performance and operational constraints may be found in the Kepler Instrument Handbook (KIH, Van Cleve Caldwell 2016). A description of Kepler calibration and data processing is described in the Kepler Data Processing Handbook (KDPH, Jenkins et al. 2016; Fanelli et al. 2011). Science users should also consult the special ApJ Letters devoted to early Kepler results and mission design (April 2010, ApJL, Vol. 713 L79-L207). Additional technical details regarding the data processing and data qualities can be found in the Kepler Data Characteristics Handbook (KDCH, Christiansen et al. 2013) and the Data Release Notes (DRN). This archive manual specifically documents the file formats, as they exist for the last data release of Kepler, Data Release 25(KSCI-19065-002). The earlier versions of the archive manual and data release notes act as documentation for the earlier versions of the data files.

Physicochemical properties of calcium silicate-based formulations MTA Repair HP and MTA Vitalcem.

PubMed

Guimarães, Bruno Martini; Prati, Carlo; Duarte, Marco Antonio Hungaro; Bramante, Clovis Monteiro; Gandolfi, Maria Giovanna

2018-04-05

This study aimed to analyze the following physicochemical properties: radiopacity, final setting time, calcium release, pH change, solubility, water sorption, porosity, surface morphology, and apatite-forming ability of two calcium silicate-based materials. We tested MTA Repair HP and MTA Vitalcem in comparison with conventional MTA, analyzing radiopacity and final setting time. Water absorption, interconnected pores and apparent porosity were measured after 24-h immersion in deionized water at 37°C. Calcium and pH were tested up to 28 d in deionized water. We analyzed data using two-way ANOVA with Student-Newman-Keuls tests (p<0.05). We performed morphological and chemical analyses of the material surfaces using ESEM/EDX after 28 d in HBSS. MTA Repair HP showed similar radiopacity to that of conventional MTA. All materials showed a marked alkalinizing activity within 3 h, which continued for 28 d. MTA Repair HP showed the highest calcium release at 28 d (p<0.05). MTA Vitalcem showed statistically higher water sorption and solubility values (p<0.05). All materials showed the ability to nucleate calcium phosphate on their surface after 28 d in HBSS. MTA Repair HP and MTA Vitalcem had extended alkalinizing activity and calcium release that favored calcium phosphate nucleation. The presence of the plasticizer in MTA HP might increase its solubility and porosity. The radiopacifier calcium tungstate can be used to replace bismuth oxide.

Physicochemical properties of calcium silicate-based formulations MTA Repair HP and MTA Vitalcem

PubMed Central

Guimarães, Bruno Martini; Prati, Carlo; Duarte, Marco Antonio Hungaro; Bramante, Clovis Monteiro; Gandolfi, Maria Giovanna

2018-01-01

Abstract Objective This study aimed to analyze the following physicochemical properties: radiopacity, final setting time, calcium release, pH change, solubility, water sorption, porosity, surface morphology, and apatite-forming ability of two calcium silicate-based materials. Material and methods We tested MTA Repair HP and MTA Vitalcem in comparison with conventional MTA, analyzing radiopacity and final setting time. Water absorption, interconnected pores and apparent porosity were measured after 24-h immersion in deionized water at 37°C. Calcium and pH were tested up to 28 d in deionized water. We analyzed data using two-way ANOVA with Student-Newman-Keuls tests (p<0.05). We performed morphological and chemical analyses of the material surfaces using ESEM/EDX after 28 d in HBSS. Results MTA Repair HP showed similar radiopacity to that of conventional MTA. All materials showed a marked alkalinizing activity within 3 h, which continued for 28 d. MTA Repair HP showed the highest calcium release at 28 d (p<0.05). MTA Vitalcem showed statistically higher water sorption and solubility values (p<0.05). All materials showed the ability to nucleate calcium phosphate on their surface after 28 d in HBSS. Conclusions MTA Repair HP and MTA Vitalcem had extended alkalinizing activity and calcium release that favored calcium phosphate nucleation. The presence of the plasticizer in MTA HP might increase its solubility and porosity. The radiopacifier calcium tungstate can be used to replace bismuth oxide. PMID:29641748

Chromoplast-specific carotenoid-associated protein appears to be important for enhanced accumulation of carotenoids in hp1 tomato fruits.

PubMed

Kilambi, Himabindu Vasuki; Kumar, Rakesh; Sharma, Rameshwar; Sreelakshmi, Yellamaraju

2013-04-01

Tomato (Solanum lycopersicum) high-pigment mutants with lesions in diverse loci such as DNA Damage-Binding Protein1 (high pigment1 [hp1]), Deetiolated1 (hp2), Zeaxanthin Epoxidase (hp3), and Intense pigment (Ip; gene product unknown) exhibit increased accumulation of fruit carotenoids coupled with an increase in chloroplast number and size. However, little is known about the underlying mechanisms exaggerating the carotenoid accumulation and the chloroplast number in these mutants. A comparison of proteome profiles from the outer pericarp of hp1 mutant and wild-type (cv Ailsa Craig) fruits at different developmental stages revealed at least 72 differentially expressed proteins during ripening. Hierarchical clustering grouped these proteins into three clusters. We found an increased abundance of chromoplast-specific carotenoid-associated protein (CHRC) in hp1 fruits at red-ripe stage that is also reflected in its transcript level. Western blotting using CHRC polyclonal antibody from bell pepper (Capsicum annuum) revealed a 2-fold increase in the abundance of CHRC protein in the red-ripe stage of hp1 fruits compared with the wild type. CHRC levels in hp2 were found to be similar to that of hp1, whereas hp3 and Ip showed intermediate levels to those in hp1, hp2, and wild-type fruits. Both CHRC and carotenoids were present in the isolated plastoglobules. Overall, our results suggest that loss of function of DDB1, DET1, Zeaxanthin Epoxidase, and Ip up-regulates CHRC levels. Increase in CHRC levels may contribute to the enhanced carotenoid content in these high-pigment fruits by assisting in the sequestration and stabilization of carotenoids.

Aurora-B/AIM-1 Regulates the Dynamic Behavior of HP1α at the G2–M Transition

PubMed Central

2006-01-01

Heterochromatin protein 1 (HP1) plays an important role in heterochromatin formation and undergoes large-scale, progressive dissociation from heterochromatin in prophase cells. However, the mechanisms regulating the dynamic behavior of HP1 are poorly understood. In this study, the role of Aurora-B was investigated with respect to the dynamic behavior of HP1α. Mammalian Aurora-B, AIM-1, colocalizes with HP1α to the heterochromatin in G2. Depletion of Aurora-B/AIM-1 inhibited dissociation of HP1α from the chromosome arms at the G2–M transition. In addition, depletion of INCENP led to aberrant cellular localization of Aurora-B/AIM-1, but it did not affect heterochromatin targeting of HP1α. It was proposed in the binary switch hypothesis that phosphorylation of histone H3 at Ser-10 negatively regulates the binding of HP1α to the adjacent methylated Lys-9. However, Aurora-B/AIM-1-mediated phosphorylation of H3 induced dissociation of the HP1α chromodomain but not of the intact protein in vitro, indicating that the center and/or C-terminal domain of HP1α interferes with the effect of H3 phosphorylation on HP1α dissociation. Interestingly, Lys-9 methyltransferase SUV39H1 is abnormally localized together along the metaphase chromosome arms in Aurora-B/AIM-1–depleted cells. In conclusion, these results showed that Aurora-B/AIM-1 is necessary for regulated histone modifications involved in binding of HP1α by the N terminus of histone H3 during mitosis. PMID:16687578

75 FR 11937 - EDS, HP Company, Fairfield Township, OH; Notice of Termination of Investigation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,710] EDS, HP Company, Fairfield Township, OH; Notice of Termination of Investigation Pursuant to Section 223 of the Trade Act of... the State on behalf of workers of EDS, HP Company, Fairfield Township, Ohio. The petitioners have...

Molecular dynamics simulation on HP1 protein binding by histone H3 tail methylation and phosphorylation

NASA Astrophysics Data System (ADS)

Jiang, Yan-Ke; Zou, Jian-Wei; Wu, Yu-Qian; Zhang, Na; Yu, Qing-Sen; Jiang, Yong-Jun

Trimethylation of histone H3 lysine 9 is important for recruiting heterochromatin protein 1 (HP1) to discrete regions of the genome, thereby regulating gene expression, chromatin packaging, and heterochromatin formation. Phosphorylation of histone H3 has been linked with mitotic chromatin condensation. During mitosis in vivo, H3 lysine 9 methylation and serine 10 phosphorylation can occur concomitantly on the same histone tail, whereas the influence of phosphorylation to trimethylation H3 tail recruiting HP1 remains controversial. In this work, molecular dynamics simulation of HP1 complexed with both trimethylated and phosphorylated H3 tail were performed and compared with the results from the previous methylated H3-HP1 trajectory. It is clear from the 10-ns dynamics simulation that two adjacent posttranslational modifications directly increase the flexibility of the H3 tail and weaken HP1 binding to chromatin. A combinatorial readout of two adjacent posttranslational modifications-a stable methylation and a dynamic phosphorylation mark-establish a regulatory mechanism of protein-protein interactions.

Community College General Academic Course Guide Manual.

ERIC Educational Resources Information Center

Texas Higher Education Coordinating Board, Austin. Div. of Community and Technical Colleges.

The Community College General Academic Course Guide Manual (ACGM) is the official list of approved numbers for general academic transfer courses that may be offered by public community and technical colleges in Texas for state funding. This edition of the ACGM, effective September 1996, contains the latest information available for academic…

NUSC Technical Publications Guide.

DTIC Science & Technology

1985-05-01

Facility personnel especially that of A. Castelluzzo, E. Deland, J. Gesel , and E. Szlosek (all of Code 4343). Reviewed and Approved: 14 July 1980 D...their technical content and format. Review and approve the manual outline, the review manuscript, and the final camera - reproducible copy. Conduct in

Battery Test Manual For Plug-In Hybrid Electric Vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeffrey R. Belt

2010-09-01

This battery test procedure manual was prepared for the United States Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Vehicle Technologies Program. It is based on technical targets established for energy storage development projects aimed at meeting system level DOE goals for Plug-in Hybrid Electric Vehicles (PHEV). The specific procedures defined in this manual support the performance and life characterization of advanced battery devices under development for PHEV’s. However, it does share some methods described in the previously published battery test manual for power-assist hybrid electric vehicles. Due to the complexity of some of the proceduresmore » and supporting analysis, a revision including some modifications and clarifications of these procedures is expected. As in previous battery and capacitor test manuals, this version of the manual defines testing methods for full-size battery systems, along with provisions for scaling these tests for modules, cells or other subscale level devices.« less

Battery Test Manual For Plug-In Hybrid Electric Vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeffrey R. Belt

2010-12-01

This battery test procedure manual was prepared for the United States Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Vehicle Technologies Program. It is based on technical targets established for energy storage development projects aimed at meeting system level DOE goals for Plug-in Hybrid Electric Vehicles (PHEV). The specific procedures defined in this manual support the performance and life characterization of advanced battery devices under development for PHEV’s. However, it does share some methods described in the previously published battery test manual for power-assist hybrid electric vehicles. Due to the complexity of some of the proceduresmore » and supporting analysis, a revision including some modifications and clarifications of these procedures is expected. As in previous battery and capacitor test manuals, this version of the manual defines testing methods for full-size battery systems, along with provisions for scaling these tests for modules, cells or other subscale level devices.« less

Administrators' Perceptions of Career and Technical Education

ERIC Educational Resources Information Center

Haussman, Charles E.

2012-01-01

Career and technical education was founded on the common practice of apprenticeships integrated into the public schools at the beginning of the 20th century as manual arts, which continued to evolve into a culture and practice of its own as vocational education, and into what is now career and technical education, with an evolving focus on college…

HP1α is highly expressed in glioma cells and facilitates cell proliferation and survival.

PubMed

Lai, Xianliang; Deng, Zhifeng; Guo, Hua; Zhu, Xingen; Tu, Wei

2017-08-19

Epigenetic alteration plays critical roles in gliomagenesis by regulating gene expression through modifications of Histones and DNA. Trimethylation of H3K9, an essential repressed transcription mark, and one of its methyltransferase, SUV39H1, are implicated in glioma pathogenesis and progression. We find that the protein level of HP1α, a reader of H3K9me3 is elevated in cultured glioma cell lines and glioma tissues. H3K9me3 is also upregulated. Depletion of HP1α and SUV39H1 weakens glioma cell proliferation capacity and results in apoptosis of cells. Furthermore, we find that HP1α and H3K9me3 are enriched in the FAS and PUMA promoters, which suggests that upregulated HP1α and H3K9me3 contribute to cell survival by suppressing apoptotic activators. These data suggests that up-regulated HP1α and H3K9me3 in glioma cells are functionally associated with glioma pathogenesis and progression and may serve as novel biomarkers for diagnostic and therapeutic targeting of brain tumors. Copyright © 2017 Elsevier Inc. All rights reserved.

Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery

NASA Astrophysics Data System (ADS)

Wu, Zhi Min; Ling, Li; Zhou, Li Ying; Guo, Xin Dong; Jiang, Wei; Qian, Yu; Luo, Kathy Qian; Zhang, Li Juan

2012-06-01

The aim of the present study was to develop the PLGA/HP55 nanoparticles with improved hypoglycemic effect for oral insulin delivery. The insulin-loaded PLGA/HP55 nanoparticles were produced by a modified multiple emulsion solvent evaporation method. The physicochemical characteristics, in vitro release of insulin, and in vivo efficacy in diabetic rats of the nanoparticles were evaluated. The insulin encapsulation efficiency was up to 94%, and insulin was released in a pH-dependent manner under simulated gastrointestinal conditions. When administered orally (50 IU/kg) to diabetic rats, the nanoparticles can decrease rapidly the blood glucose level with a maximal effect between 1 and 8 h. The relative bioavailability compared with subcutaneous injection (5 IU/kg) in diabetic rats was 11.3% ± 1.05%. This effect may be explained by the fast release of insulin in the upper intestine, where it is better absorbed by the high gradient concentration of insulin than other regions. These results show that the PLGA/HP55 nanoparticles developed in the study might be employed as a potential method for oral insulin delivery.

78 FR 48468 - Hewlett Packard Company, Hewlett Packard Enterprise Business Unit, EG HP Storage, Enterprise...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

..., Hewlett Packard Enterprise Business Unit, EG HP Storage, Enterprise Storage, Servers and Networking Storage, APP Management, Research and Development Group, Andover, Massachusetts; Notice of Investigation... Enterprise Business Unit, EG HP Storage, Enterprise Storage, Servers and Networking Storage Division, APP...

Small Enterprise Development In-Service Training Manual. Training for Development. Peace Corps Information Collection & Exchange Training Manual No. T-43.

ERIC Educational Resources Information Center

Pragma Corp., Falls Church, VA.

This manual is intended to assist Peace Corps trainers in providing inservice technical training in small enterprise development. The following topics are covered: expectations and sharing of resources, problem analysis as a part of project identification, procedures in setting goals and objectives, steps in identifying project resources, the…

dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.

PubMed

Chavez, Joselyn; Murillo-Maldonado, Juan Manuel; Bahena, Vanessa; Cruz, Ana Karina; Castañeda-Sortibrán, América; Rodriguez-Arnaiz, Rosario; Zurita, Mario; Valadez-Graham, Viviana

2017-12-01

Telomeres are important contributors to genome stability, as they prevent linear chromosome end degradation and contribute to the avoidance of telomeric fusions. An important component of the telomeres is the heterochromatin protein 1a (HP1a). Mutations in Su(var)205, the gene encoding HP1a in Drosophila, result in telomeric fusions, retrotransposon regulation loss and larger telomeres, leading to chromosome instability. Previously, it was found that several proteins physically interact with HP1a, including dXNP and dAdd1 (orthologues to the mammalian ATRX gene). In this study, we found that mutations in the genes encoding the dXNP and dAdd1 proteins affect chromosome stability, causing chromosomal aberrations, including telomeric defects, similar to those observed in Su(var)205 mutants. In somatic cells, we observed that dXNP and dAdd1 participate in the silencing of the telomeric HTT array of retrotransposons, preventing anomalous retrotransposon transcription and integration. Furthermore, the lack of dAdd1 results in the loss of HP1a from the telomeric regions without affecting other chromosomal HP1a binding sites; mutations in dxnp also affected HP1a localization but not at all telomeres, suggesting a specialized role for dAdd1 and dXNP proteins in locating HP1a at the tips of the chromosomes. These results place dAdd1 as an essential regulator of HP1a localization and function in the telomere heterochromatic domain.

Electronic polarization stabilizes tertiary structure prediction of HP-36.

PubMed

Duan, Li L; Zhu, Tong; Zhang, Qing G; Tang, Bo; Zhang, John Z H

2014-04-01

Molecular dynamic (MD) simulations with both implicit and explicit solvent models have been carried out to study the folding dynamics of HP-36 protein. Starting from the extended conformation, the secondary structure of all three helices in HP-36 was formed in about 50 ns and remained stable in the remaining simulation. However, the formation of the tertiary structure was difficult. Although some intermediates were close to the native structure, the overall conformation was not stable. Further analysis revealed that the large structure fluctuation of loop and hydrophobic core regions was devoted mostly to the instability of the structure during MD simulation. The backbone root-mean-square deviation (RMSD) of the loop and hydrophobic core regions showed strong correlation with the backbone RMSD of the whole protein. The free energy landscape indicated that the distribution of main chain torsions in loop and turn regions was far away from the native state. Starting from an intermediate structure extracted from the initial AMBER simulation, HP-36 was found to generally fold to the native state under the dynamically adjusted polarized protein-specific charge (DPPC) simulation, while the peptide did not fold into the native structure when AMBER force filed was used. The two best folded structures were extracted and taken into further simulations in water employing AMBER03 charge and DPPC for 25 ns. Result showed that introducing polarization effect into interacting potential could stabilize the near-native protein structure.

75 FR 34169 - Hewlett-Packard Company, Inkjet Consumer Solutions, HP Consumer Hardware Inkjet Lab, Including...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

..., Inkjet Consumer Solutions, HP Consumer Hardware Inkjet Lab, Including Leased Workers From Hightower..., applicable to all workers of Hewlett-Packard Company, Inkjet Consumer Solutions, HP Consumer Hardware Inkjet... the Department's certification is to include all workers employed at Hewlett Packard Company, Inkjet...

77 FR 20520 - Airworthiness Directives; Bombardier, Inc. Model BD-100-1A10 (Challenger 300) Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-05

... Bombardier Challenger 300 BD-100 Time Limits/Maintenance Checks Manual. For this task, the initial compliance..., of Part 2, of the Bombardier Challenger 300 BD-100 Time Limits/Maintenance Checks Manual, the general.../Maintenance Checks Manual, provided that the relevant information in the general revision is identical to that...

Load research manual. Volume 3. Load research for advanced technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandenburg, L.; Clarkson, G.; Grund, Jr., C.

1980-11-01

This three-volume manual presents technical guidelines for electric utility load research. Special attention is given to issues raised by the load data reporting requirements of the Public Utility Regulatory Policies Act of 1978 and to problems faced by smaller utilities that are initiating load research programs. The manual includes guides to load research literature and glossaries of load research and statistical terms. In Volume 3, special load research procedures are presented for solar, wind, and cogeneration technologies.

Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moriyama, Tetsuji; Sangel, Percival; Yamaguchi, Hiroki

2015-07-03

Tripartite motif-containing 28 (TRIM28) is a transcription regulator, which forms a repressor complex containing heterochromatin protein 1 (HP1). Here, we report identification of a nuclear localization signal (NLS) within the 462-494 amino acid region of TRIM28 that overlaps with its HP1 binding site, HP1 box. GST-pulldown experiments revealed the interaction of the arginine-rich TRIM28 NLS with various importin α subtypes (α1, α2 and α4). In vitro transport assay demonstrated that nuclear localization of GFP-TRIM28 NLS is mediated by importin αs, in conjunction with importin β1 and Ran. Further, we demonstrated that HP1 and importin αs compete for binding to TRIM28. Together,more » our findings suggest that importin α has an essential role in the nuclear delivery and preferential HP1 interaction of TRIM28. - Highlights: • TRIM28 contains an NLS within the 462-494 amino acid region. • The nuclear import of TRIM28 is mediated by importin α/importin β1. • TRIM28 NLS overlaps with HP1 Box. • HP1 and importin α compete for binding to TRIM28.« less

High School and Beyond Transcripts Survey (1982). Data File User's Manual. Contractor Report.

ERIC Educational Resources Information Center

Jones, Calvin; And Others

This data file user's manual documents the procedures used to collect and process high school transcripts for a large sample of the younger cohort (1980 sophomores) in the High School and Beyond survey. The manual provides the user with the technical assistance needed to use the computer file and also discusses the following: (1) sample design for…

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells

PubMed Central

Kang, Jungseog; Chaudhary, Jaideep; Dong, Hui; Kim, Soonjoung; Brautigam, Chad A.; Yu, Hongtao

2011-01-01

Human Shugoshin 1 (Sgo1) protects centromeric sister-chromatid cohesion during prophase and prevents premature sister-chromatid separation. Heterochromatin protein 1 (HP1) has been proposed to protect centromeric sister-chromatid cohesion by directly targeting Sgo1 to centromeres in mitosis. Here we show that HP1α is targeted to mitotic centromeres by INCENP, a subunit of the chromosome passenger complex (CPC). Biochemical and structural studies show that both HP1–INCENP and HP1–Sgo1 interactions require the binding of the HP1 chromo shadow domain to PXVXL/I motifs in INCENP or Sgo1, suggesting that the INCENP-bound, centromeric HP1α is incapable of recruiting Sgo1. Consistently, a Sgo1 mutant deficient in HP1 binding is functional in centromeric cohesion protection and localizes normally to centromeres in mitosis. By contrast, INCENP or Sgo1 mutants deficient in HP1 binding fail to localize to centromeres in interphase. Therefore, our results suggest that HP1 binding by INCENP or Sgo1 is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet uncharacterized interphase functions of CPC or Sgo1 at the centromeres. PMID:21346195

Mutations to essential orphan response regulator HP1043 of Helicobacter pylori result in growth-stage regulatory defects.

PubMed

Olekhnovich, Igor N; Vitko, Serhiy; Chertihin, Olga; Hontecillas, Raquel; Viladomiu, Monica; Bassaganya-Riera, Josep; Hoffman, Paul S

2013-05-01

Helicobacter pylori establishes lifelong infections of the gastric mucosa, a niche considered hostile to most microbes. While responses to gastric acidity and local inflammation are understood, little is known as to how they are integrated into homeostatic control of cell division and growth-stage gene expression. Here we investigate the essential orphan response regulator HP1043, a member of the OmpR/PhoB subfamily of transcriptional regulators that is unique to the Epsilonproteobacteria and that lacks phosphorylation domains. To test the hypothesis that conformational changes in the homodimer might lead to defects in gene expression, we sought mutations that might alter DNA-binding efficiency. Two introduced mutations (C215S, C221S) C terminal to the DNA-binding domain of HP1043 (HP1043CC11) resulted in a 2-fold higher affinity for its own promoter by footprinting. Modeling studies with the crystal structure of HP1043 suggested that C215S might affect the helix-turn-helix domain. Genomic replacement of the hp1043 allele with the hp1043CC11 mutant allele resulted in a 2-fold decrease in protein levels, despite a dramatic increase in mRNA. The mutations did not affect in vitro growth rates or colonization efficiency in a mouse model. Proteomic profiling (CC11 mutant strain versus wild type) identified many expression differences, and quantitative PCR further revealed that 11 out of 12 examined genes had lost growth-stage regulation and that 6 of the genes contained HP1043 binding consensus sequences within the promoter regions (fur, cagA, cag23, flhA, flip, and napA). Our studies show that mutations that affect DNA-binding affinity can be used to identify new members of the HP1043 regulon.

Reference Manual for Machine-Readable Bibliographic Descriptions.

ERIC Educational Resources Information Center

Martin, M. D., Comp.

UNESCO, in cooperation with several other organizations, has produced a manual, the scope and purpose of which has been to define, for most types of scientific and technical literature, a set of data elements which will constitute an adequate bibliographic citation, and to define the representation of these data elements as they should appear in a…

The WRKY transcription factor HpWRKY44 regulates CytP450-like1 expression in red pitaya fruit (Hylocereus polyrhizus).

PubMed

Cheng, Mei-Nv; Huang, Zi-Juan; Hua, Qing-Zhu; Shan, Wei; Kuang, Jian-Fei; Lu, Wang-Jin; Qin, Yong-Hua; Chen, Jian-Ye

2017-01-01

Red pitaya ( Hylocereus polyrhizus ) fruit is a high-value, functional food, containing a high level of betalains. Several genes potentially related to betalain biosynthesis, such as cytochrome P450-like ( CytP450-like ), have been identified in pitaya fruit, while their transcriptional regulation remains unclear. In this work, the potential involvement of a WRKY transcription factor, HpWRKY44, in regulating CytP450-like1 expression in pitaya fruit was examined. HpWRKY44, a member of the Group 1 WRKY family, contains two conserved WRKY motifs and is localized in the nucleus. HpWRKY44 also exhibits trans-activation ability. Gene expression analysis showed that the expression of HpCytP450-like1 and HpWRKY44 increased steadily during pitaya fruit coloration, which corresponded with the production of elevated betalain levels in the fruit. HpWRKY44 was also demonstrated to directly bind to and activate the HpCytP450-like1 promoter via the recognition of the W-box element present in the promoter. Collectively, our findings indicate that HpWRKY44 transcriptionally activates HpCytP450-like1 , which perhaps, at least in part, contributes to betalain biosynthesis in pitaya fruit. The information provided in the current study provides novel insights into the regulatory network associated with betalain biosynthesis during pitaya fruit coloration.

NASA Safety Manual. Volume 3: System Safety

NASA Technical Reports Server (NTRS)

1970-01-01

This Volume 3 of the NASA Safety Manual sets forth the basic elements and techniques for managing a system safety program and the technical methods recommended for use in developing a risk evaluation program that is oriented to the identification of hazards in aerospace hardware systems and the development of residual risk management information for the program manager that is based on the hazards identified. The methods and techniques described in this volume are in consonance with the requirements set forth in NHB 1700.1 (VI), Chapter 3. This volume and future volumes of the NASA Safety Manual shall not be rewritten, reprinted, or reproduced in any manner. Installation implementing procedures, if necessary, shall be inserted as page supplements in accordance with the provisions of Appendix A. No portion of this volume or future volumes of the NASA Safety Manual shall be invoked in contracts.

175Hp contrarotating homopolar motor design report

NASA Astrophysics Data System (ADS)

Cannell, Michael J.; Drake, John L.; McConnell, Richard A.; Martino, William R.

1994-06-01

A normally conducting contrarotating homopolar motor has been designed and constructed. The reaction torque, in the outer rotor, from the inner rotor is utilized to produce true contrarotation. The machine utilizes liquid cooled conductors, high performance liquid metal current collectors, and ferrous conductors in the active region. The basic machine output is 175 hp at + or - 1,200 rpm with an input of 4 volts and 35,000 amps.

47 CFR 301.100 - Membership.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Membership. 301.100 Section 301.100 Telecommunication NATIONAL TELECOMMUNICATIONS AND INFORMATION ADMINISTRATION, DEPARTMENT OF COMMERCE RELOCATION OF AND SPECTRUM SHARING BY FEDERAL GOVERNMENT STATIONS Technical Panel § 301.100 Membership. (a...

47 CFR 301.100 - Membership.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Membership. 301.100 Section 301.100 Telecommunication NATIONAL TELECOMMUNICATIONS AND INFORMATION ADMINISTRATION, DEPARTMENT OF COMMERCE RELOCATION OF AND SPECTRUM SHARING BY FEDERAL GOVERNMENT STATIONS Technical Panel § 301.100 Membership. (a...

Construction of a dictionary of laboratory tests mapped to LOINC at AP-HP.

PubMed

Cormont, Sylvie; Buemi, Antoine; Horeau, Thierry; Zweigenbaum, Pierre; Lepage, Eric

2008-11-06

We report on the ongoing process implemented at Assistance Publique-Hôpitaux de Paris (AP-HP), the largest hospital system in Europe, to build a common reference for laboratory tests in French with LOINC mappings. At the time of writing, it contained 24,000 tests, covering all fields of biology, in use in 19 AP-HP hospitals, 30% of which had a mapping to LOINC with a peak of over 60% in biochemistry.

Utilitiesman 3 and 2. Rate Training Manual. Revised 1973.

ERIC Educational Resources Information Center

Naval Training Command, Pensacola, FL.

This Rate Training Manual provides the technical knowledge and skill requirements necessary to prepare Utilitiesmen to perform tasks involved in the installation, maintenance, and repair of plumbing, heating, steam, fuel storage and distribution systems, water treatment and distribution systems, air conditioning and refrigeration equipment, and…

Technical Manual for Batteries, Navy Lithium Safety Program Responsibilities and Procedures

DTIC Science & Technology

2004-08-19

lithium ion batteries and all equipment powered by lithium electrochemical power source(s) through all phases of the life of such systems. The purpose of this manual is to establish safety guidelines for the selection, design, testing, evaluation, use, packaging, storage, transportation and disposal of lithium

Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC), version 4.0: User's manual

NASA Technical Reports Server (NTRS)

Whyte, Wayne A., Jr.; Heyward, Ann O.; Ponchak, Denise S.; Spence, Rodney L.; Zuzek, John E.

1988-01-01

The information in the NASARC (Version 4.0) Technical Manual (NASA-TM-101453) and NASARC (Version 4.0) User's Manual (NASA-TM-101454) relates to the state of Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC) software development through November 1, 1988. The Technical Manual describes the NASARC concept and the algorithms used to implement the concept. The User's Manual provides information on computer system considerations, installation instructions, description of input files, and program operation instructions. Significant revisions were incorporated in the Version 4.0 software over prior versions. These revisions have further enhanced the modeling capabilities of the NASARC procedure and provide improved arrangements of predetermined arcs within the geostationary orbit. Array dimensions within the software were structured to fit within the currently available 12-megabyte memory capacity of the International Frequency Registration Board (IFRB) computer facility. A piecewise approach to predetermined arc generation in NASARC (Version 4.) allows worldwide planning problem scenarios to be accommodated within computer run time and memory constraints with enhanced likelihood and ease of solution.

Numerical Arc Segmentation Algorithm for a Radio Conference-NASARC, Version 2.0: User's Manual

NASA Technical Reports Server (NTRS)

Whyte, Wayne A., Jr.; Heyward, Ann O.; Ponchak, Denise S.; Spence, Rodney L.; Zuzek, John E.

1987-01-01

The information contained in the NASARC (Version 2.0) Technical Manual (NASA TM-100160) and the NASARC (Version 2.0) User's Manual (NASA TM-100161) relates to the state of the Numerical Arc Segmentation Algorithm for a Radio Conference (NASARC) software development through October 16, 1987. The technical manual describes the NASARC concept and the algorithms which are used to implement it. The User's Manual provides information on computer system considerations, installation instructions, description of input files, and program operation instructions. Significant revisions have been incorporated in the Version 2.0 software over prior versions. These revisions have enhanced the modeling capabilities of the NASARC procedure while greatly reducing the computer run time and memory requirements. Array dimensions within the software have been structured to fit into the currently available 6-megabyte memory capacity of the International Frequency Registration Board (IFRB) computer facility. A piecewise approach to predetermined arc generation in NASARC (Version 2.0) allows worldwide scenarios to be accommodated within these memory constraints while at the same time reducing computer run time.

OSMEAN - OSCULATING/MEAN CLASSICAL ORBIT ELEMENTS CONVERSION (HP9000/7XX VERSION)

NASA Technical Reports Server (NTRS)

Guinn, J. R.

1994-01-01

OSMEAN is a sophisticated FORTRAN algorithm that converts between osculating and mean classical orbit elements. Mean orbit elements are advantageous for trajectory design and maneuver planning since they can be propagated very quickly; however, mean elements cannot describe the exact orbit at any given time. Osculating elements will enable the engineer to give an exact description of an orbit; however, computation costs are significantly higher due to the numerical integration procedure required for propagation. By calculating accurate conversions between osculating and mean orbit elements, OSMEAN allows the engineer to exploit the advantages of each approach for the design and planning of orbital trajectories and maneuver planning. OSMEAN is capable of converting mean elements to osculating elements or vice versa. The conversion is based on modelling of all first order aspherical and lunar-solar gravitation perturbations as well as a second-order aspherical term based on the second degree central body zonal perturbation. OSMEAN is written in FORTRAN 77 for HP 9000 series computers running HP-UX (NPO-18796) and DEC VAX series computers running VMS (NPO-18741). The HP version requires 388K of RAM for execution and the DEC VAX version requires 254K of RAM for execution. Sample input and output are listed in the documentation. Sample input is also provided on the distribution medium. The standard distribution medium for the HP 9000 series version is a .25 inch streaming magnetic IOTAMAT tape cartridge in UNIX tar format. It is also available on a .25 inch streaming magnetic tape cartridge in UNIX tar format or on a 3.5 inch diskette in UNIX tar format. The standard distribution medium for the DEC VAX version is a 1600 BPI 9-track magnetic tape in DEC VAX BACKUP format. It is also available on a TK50 tape cartridge in DEC VAX BACKUP format. OSMEAN was developed on a VAX 6410 in 1989, and was ported to the HP 9000 series platform in 1991. It is a copyrighted work with

The influence of supervision on manual adherence and therapeutic processes.

PubMed

Anderson, Timothy; Crowley, Mary Ellen J; Patterson, Candace L; Heckman, Bernadette D

2012-09-01

To identify the effectiveness of psychotherapy supervision on therapists' immediate (next session) and long-term (1 year) adherence to time-limited dynamic psychotherapy (TLDP). Sixteen therapists from the Vanderbilt II psychotherapy project were assigned new cases in pretraining, training, and booster/posttraining year-long cohorts. Technical adherence to the manual, as well as general therapeutic relational processes, were rated for clinical supervisory sessions in which the third therapy session was discussed. The therapy sessions immediately before and after the supervisory sessions were also rated for technical adherence and relational processes. Postsupervision adherence increased from the presupervision session during the training cohort. In supervision, therapists' discussion of techniques and strategies from the manual in supervision was significantly related to technical adherence in the session prior to (but not after) supervision. However, supervisors' discussion of specific techniques predicted therapists' total technical adherence in the therapy session after (but not before) supervision. In terms of the type of techniques, supervisors' influenced postsupervision therapy adherence on TLDP's unique approach to formulation, the cyclical maladaptive pattern, but did not influence technical adherence on the therapeutic relationship. In supervision, therapists tend to focus on how they adhered to techniques from the previous session, whereas supervisors' comments about specific techniques predicted how the therapist would adhere to techniques in the next therapy session. The findings provide support for the immediate effects of supervision in shaping therapist techniques as well as highlighting the challenges of altering common relational processes through technical training. © 2012 Wiley Periodicals, Inc.

LEO to GEO (and Beyond) Transfers Using High Power Solar Electric Propulsion (HP-SEP)

NASA Technical Reports Server (NTRS)

Loghry, Christopher S.; Oleson, Steven R.; Woytach, Jeffrey M.; Martini, Michael C.; Smith, David A.; Fittje, James E.; Gyekenyesi, John Z.; Colozza, Anthony J.; Fincannon, James; Bogner, Aimee;

[Comparison of port needle with safety device between Huber Plus (HP) and Poly PERF Safe (PPS)].

PubMed

Shimono, Chigusa; Tanaka, Atsuko; Fujita, Ai; Ishimoto, Miki; Oura, Shoji; Yamaue, Hiroki; Sato, Morio

2010-05-01

An embedded port is frequently used for outpatients with advanced cancer in central venous chemotherapy or hepatic arterial chemoinfusion. The port needle with a safety device in an ambulatory treatment center is indispensable for medical employees and patient plus family to reduce the risk of a needle puncture accident and to prevent iatrogenic infection. The port needle with safety system has been already introduced in our chemotherapy center. There are two types of port needle with safety device; Huber Plus (HP, Medicon Co., Ltd.) and POLY PERF Safe (PPS, Pyolax Device, Co., Ltd.). The comparison of the feasibility between HP and PPS was conducted by both medical employees and patients plus family using an inquiry score method. HP was highly regarded for its stability plus fixation and PPS for its usefulness in puncture and extraction of the needle. PPS was found to be preferable to HP based on the overall evaluation.

The CompHP core competencies framework for health promotion in Europe.

PubMed

Barry, Margaret M; Battel-Kirk, Barbara; Dempsey, Colette

2012-12-01

The CompHP Project on Developing Competencies and Professional Standards for Health Promotion in Europe was developed in response to the need for new and changing health promotion competencies to address health challenges. This article presents the process of developing the CompHP Core Competencies Framework for Health Promotion across the European Union Member States and Candidate Countries. A phased, multiple-method approach was employed to facilitate a consensus-building process on the development of the core competencies. Key stakeholders in European health promotion were engaged in a layered consultation process using the Delphi technique, online consultations, workshops, and focus groups. Based on an extensive literature review, a mapping process was used to identify the core domains, which informed the first draft of the Framework. A consultation process involving two rounds of a Delphi survey with national experts in health promotion from 30 countries was carried out. In addition, feedback was received from 25 health promotion leaders who participated in two focus groups at a pan-European level and 116 health promotion practitioners who engaged in four country-specific consultations. A further 54 respondents replied to online consultations, and there were a number of followers on various social media platforms. Based on four rounds of redrafting, the final Framework document was produced, consisting of 11 core domains and 68 core competency statements. The CompHP Core Competencies Framework for Health Promotion provides a resource for workforce development in Europe, by articulating the necessary knowledge, skills, and abilities that are required for effective practice. The core domains are based on the multidisciplinary concepts, theories, and research that make health promotion distinctive. It is the combined application of all the domains, the knowledge base, and the ethical values that constitute the CompHP Core Competencies Framework for Health

A study on directional resistivity logging-while-drilling based on self-adaptive hp-FEM

NASA Astrophysics Data System (ADS)

Liu, Dejun; Li, Hui; Zhang, Yingying; Zhu, Gengxue; Ai, Qinghui

2014-12-01

Numerical simulation of resistivity logging-while-drilling (LWD) tool response provides guidance for designing novel logging instruments and interpreting real-time logging data. In this paper, based on self-adaptive hp-finite element method (hp-FEM) algorithm, we analyze LWD tool response against model parameters and briefly illustrate geosteering capabilities of directional resistivity LWD. Numerical simulation results indicate that the change of source spacing is of obvious influence on the investigation depth and detecting precision of resistivity LWD tool; the change of frequency can improve the resolution of low-resistivity formation and high-resistivity formation. The simulation results also indicate that the self-adaptive hp-FEM algorithm has good convergence speed and calculation accuracy to guide the geologic steering drilling and it is suitable to simulate the response of resistivity LWD tools.

Hierarchical folding free energy landscape of HP35 revealed by most probable path clustering.

PubMed

Jain, Abhinav; Stock, Gerhard

2014-07-17

Adopting extensive molecular dynamics simulations of villin headpiece protein (HP35) by Shaw and co-workers, a detailed theoretical analysis of the folding of HP35 is presented. The approach is based on the recently proposed most probable path algorithm which identifies the metastable states of the system, combined with dynamical coring of these states in order to obtain a consistent Markov state model. The method facilitates the construction of a dendrogram associated with the folding free-energy landscape of HP35, which reveals a hierarchical funnel structure and shows that the native state is rather a kinetic trap than a network hub. The energy landscape of HP35 consists of the entropic unfolded basin U, where the prestructuring of the protein takes place, the intermediate basin I, which is connected to U via the rate-limiting U → I transition state reflecting the formation of helix-1, and the native basin N, containing a state close to the NMR structure and a native-like state that exhibits enhanced fluctuations of helix-3. The model is in line with recent experimental observations that the intermediate and native states differ mostly in their dynamics (locked vs unlocked states). Employing dihedral angle principal component analysis, subdiffusive motion on a multidimensional free-energy surface is found.

Morphological study on permeating efficiency and localization of FCLA and HpD through membrane of lung cancer cell

NASA Astrophysics Data System (ADS)

Wu, Yunxia; Xing, Da; Tang, Yonghong

2004-07-01

It is reported that apoptosis of cancer cells in photodynamic therapy (PDT) is caused by 1O2 generated in photosensitization. In order to study the mechanism of this kind of 1O2-induced apoptosis, it is necessary to establish a special technique to dynamically detect intracellular production and localization of 1O2. FCLA, as a chemiluminescence probe to detect singlet oxygen (1O2) and superoxide (O2-.), has been used successfully in photodynamic and sonodynamic diagnosis in tissue level, recently. This paper reported a preliminary result of morphological study on permeating efficiency and localization of FCLA and hematoporphyrin derivative (HpD) through cellular membrane. Human lung cancer cell line (ASTC-a-1) was used in the experiment. The result of this research showed that both HpD and FCLA could permeate through cellular membrane and localize to prinuclear area, when HpD or FCLA was incubated with cells. Although the molecular weight of HpD is close to FCLA's, the permeating efficiency of HpD through membrane was different from that of FCLA. Intracellular FCLA concentration reached a peak after incubation for only 30 - 45 minutes, but amount of HpD in cells approached the equilibrium after incubation for near 22 h. In the experiment, we did not observe the evidence of FCLA or HpD penetrating into nucleolus. This study suggests that it is possibly to use a specific chemiluminescence probe to dynamcially detect the production and localization of 1O2 or 02-. in cell.

Endogenous Retrovirus EAV-HP Linked to Blue Egg Phenotype in Mapuche Fowl

PubMed Central

Alcalde, José A.; Wang, Chen; Han, Jian-Lin; Gongora, Jaime; Gourichon, David; Tixier-Boichard, Michèle; Hanotte, Olivier

2013-01-01

Oocyan or blue/green eggshell colour is an autosomal dominant trait found in native chickens (Mapuche fowl) of Chile and in some of their descendants in European and North American modern breeds. We report here the identification of an endogenous avian retroviral (EAV-HP) insertion in oocyan Mapuche fowl and European breeds. Sequencing data reveals 100% retroviral identity between the Mapuche and European insertions. Quantitative real-time PCR analysis of European oocyan chicken indicates over-expression of the SLCO1B3 gene (P<0.05) in the shell gland and oviduct. Predicted transcription factor binding sites in the long terminal repeats (LTR) indicate AhR/Ar, a modulator of oestrogen, as a possible promoter/enhancer leading to reproductive tissue-specific over-expression of the SLCO1B3 gene. Analysis of all jungle fowl species Gallus sp. supports the retroviral insertion to be a post-domestication event, while identical LTR sequences within domestic chickens are in agreement with a recent de novo mutation. PMID:23990950

Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl.

PubMed

Wragg, David; Mwacharo, Joram M; Alcalde, José A; Wang, Chen; Han, Jian-Lin; Gongora, Jaime; Gourichon, David; Tixier-Boichard, Michèle; Hanotte, Olivier

2013-01-01

Oocyan or blue/green eggshell colour is an autosomal dominant trait found in native chickens (Mapuche fowl) of Chile and in some of their descendants in European and North American modern breeds. We report here the identification of an endogenous avian retroviral (EAV-HP) insertion in oocyan Mapuche fowl and European breeds. Sequencing data reveals 100% retroviral identity between the Mapuche and European insertions. Quantitative real-time PCR analysis of European oocyan chicken indicates over-expression of the SLCO1B3 gene (P<0.05) in the shell gland and oviduct. Predicted transcription factor binding sites in the long terminal repeats (LTR) indicate AhR/Ar, a modulator of oestrogen, as a possible promoter/enhancer leading to reproductive tissue-specific over-expression of the SLCO1B3 gene. Analysis of all jungle fowl species Gallus sp. supports the retroviral insertion to be a post-domestication event, while identical LTR sequences within domestic chickens are in agreement with a recent de novo mutation.

Ethnicity/culture modulates the relationships of the haptoglobin (Hp) 1-1 phenotype with cognitive function in older individuals with type 2 diabetes.

PubMed

Guerrero-Berroa, Elizabeth; Ravona-Springer, Ramit; Heymann, Anthony; Schmeidler, James; Hoffman, Hadas; Preiss, Rachel; Koifmann, Keren; Greenbaum, Lior; Levy, Andrew; Silverman, Jeremy M; Leroith, Derek; Sano, Mary; Schnaider-Beeri, Michal

2016-05-01

The haptoglobin (Hp) genotype has been associated with cognitive function in type 2 diabetes. Because ethnicity/culture has been associated with both cognitive function and Hp genotype frequencies, we examined whether it modulates the association of Hp with cognitive function. This cross-sectional study evaluated 787 cognitively normal older individuals (>65 years of age) with type 2 diabetes participating in the Israel Diabetes and Cognitive Decline study. Interactions in two-way analyses of covariance compared Group (Non-Ashkenazi versus Ashkenazi Jews) on the associations of Hp phenotype (Hp 1-1 versus non- Hp 1-1) with five cognitive outcome measures. The primary control variables were age, gender, and education. Compared with Ashkenazi Jews, non-Ashkenazi Jews with the Hp 1-1 phenotype had significantly poorer cognitive function than non-Hp 1-1 in the domains of Attention/Working Memory (p = 0.035) and Executive Function (p = 0.023), but not in Language/Semantic Categorization (p = 0.432), Episodic Memory (p = 0.268), or Overall Cognition (p = 0.082). After controlling for additional covariates (type 2 diabetes-related characteristics, cardiovascular risk factors, Mini-mental State Examination, and extent of depressive symptoms), Attention/Working Memory (p = 0.038) and Executive Function (p = 0.013) remained significant. Older individuals from specific ethnic/cultural backgrounds with the Hp 1-1 phenotype may benefit more from treatment targeted at decreasing or halting the detrimental effects of Hp 1-1 on the brain. Future studies should examine differential associations of Hp 1-1 and cognitive impairment, especially for groups with high prevalence of both, such as African-Americans and Hispanics. Copyright © 2015 John Wiley & Sons, Ltd.

Simplified Procedures for Eutrophication Assessment and Prediction: User Manual

DTIC Science & Technology

1996-09-01

1975), for use in the Lake Erie Wastewater Management Study and is described by Verhoff, Yaksich, and Melfi (1980) and Westerdahl et al. (1981). This...manual," Technical Re- port E-81-9, U.S. Army Engineer Waterways Experiment Station, Vicksburg, MS. Westerdahl , H. E., Ford, W. B., Harris, J., and

32 CFR 518.21 - Collection of fees and fee rates for technical data.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Fee rates-(1) Costs for a manual search of technical data. Type Grade Hourly rate ($) Clerical E9/GS 8... costs for technical data. Type Cost ($) Aerial photograph, maps, specifications, permits, charts... microfilm indices, each .10 (e) Review time costs of technical data. Type Grade Hourly rate($) Clerical E9...

32 CFR 518.21 - Collection of fees and fee rates for technical data.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Fee rates-(1) Costs for a manual search of technical data. Type Grade Hourly rate ($) Clerical E9/GS 8... costs for technical data. Type Cost ($) Aerial photograph, maps, specifications, permits, charts... microfilm indices, each .10 (e) Review time costs of technical data. Type Grade Hourly rate($) Clerical E9...

32 CFR 518.21 - Collection of fees and fee rates for technical data.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Fee rates-(1) Costs for a manual search of technical data. Type Grade Hourly rate ($) Clerical E9/GS 8... costs for technical data. Type Cost ($) Aerial photograph, maps, specifications, permits, charts... microfilm indices, each .10 (e) Review time costs of technical data. Type Grade Hourly rate($) Clerical E9...

32 CFR 518.21 - Collection of fees and fee rates for technical data.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Fee rates-(1) Costs for a manual search of technical data. Type Grade Hourly rate ($) Clerical E9/GS 8... costs for technical data. Type Cost ($) Aerial photograph, maps, specifications, permits, charts... microfilm indices, each .10 (e) Review time costs of technical data. Type Grade Hourly rate($) Clerical E9...

Helicobacter pylori antigen HP0986 (TieA) interacts with cultured gastric epithelial cells and induces IL8 secretion via NF-κB mediated pathway.

PubMed

Devi, Savita; Ansari, Suhail A; Vadivelu, Jamuna; Mégraud, Francis; Tenguria, Shivendra; Ahmed, Niyaz

2014-02-01

The envisaged roles and partly understood functional properties of Helicobacter pylori protein HP0986 are significant in the context of proinflammatory and or proapoptotic activities, the two important facilitators of pathogen survival and persistence. In addition, sequence analysis of this gene predicts a restriction endonuclease function which remained unknown thus far. To evaluate the role of HP0986 in gastric inflammation, we studied its expression profile using a large number of clinical isolates but a limited number of biopsies and patient sera. Also, we studied antigenic role of HP0986 in altering cytokine responses of human gastric epithelial (AGS) cells including its interaction with and localization within the AGS cells. For in vitro expression study of HP0986, 110 H. pylori clinical isolates were cultured from patients with functional dyspepsia. For expression analysis by qRT PCR of HP0986, 10 gastric biopsy specimens were studied. HP0986 was also used to detect antibodies in patient sera. AGS cells were incubated with recombinant HP0986 to determine cytokine response and NF-κB activation. Transient transfection with HP0986 cloned in pEGFPN1 was used to study its subcellular localization or homing in AGS cells. Out of 110 cultured H. pylori strains, 34 (31%) were positive for HP0986 and this observation was correlated with in vitro expression profiles. HP0986 mRNA was detected in 7 of the 10 biopsy specimens. Further, HP0986 induced IL-8 secretion in gastric epithelial cells in a dose and time-dependent manner via NF-κB pathway. Serum antibodies against HP0986 were positively associated with H. pylori positive patients. Transient transfection of AGS cells revealed both cytoplasmic and nuclear localization of HP0986. HP0986 was moderately prevalent in clinical isolates and its expression profile in cultures and gastric biopsies points to its being naturally expressed. Collective observations including the induction of IL-8 via TNFR1 and NF

Investigating the origins of rhythmic major-element zoning in HP/LT garnets from worldwide subduction mélanges

NASA Astrophysics Data System (ADS)

Viete, D. R.; Hacker, B. R.; Seward, G.; Allen, M. B.

2016-12-01

Rhythmic major-element zoning has been documented in garnets from high pressure/low temperature (HP/LT) lenses within a number of worldwide subduction mélanges (e.g. California, Chinese Tianshan, Cuba, Greek Cyclades, Guatemala, Japan, Venezuela). The origin of these features has implications for the nature of subduction-zone processes. Conditions of rhythmic zoning acquirement in HP/LT garnets of California and Venezuela were investigated by use of Raman and FTIR microspectroscopy, and thermodynamic modelling of phase equilibria. Quartz-in-garnet Raman barometry reveals varying P—on the order of 100­-300 MPa, over radial distances of 10s of µm—in association with the high-Mn (and low-Mg) bands that define the fine-scale rhythmic zoning. Results from FTIR microspectroscopy demonstrate association between the high-Mn bands and locally depressed (structural) OH and elevated (molecular) H2O concentrations. The microspectroscopy results suggest changes in P and fluid activity attended development of the cryptic rhythmic zoning. Perple_X modelling of phase equilibria shows that, for specific rock chemistry and subduction P-T conditions, garnet modal abundance is extremely sensitive to changes in P (e.g. 10-20 vol.% growth/dissolution for ΔP = 200 MPa). Rhythmic major-element zoning may reflect P- and/or fluid-driven cycles of garnet stability-instability and/or varying reaction progress/kinetics during subduction. Steep compositional gradients that define the rhythmic major-element zoning limit time scales at subduction T, requiring that such individual stability-instability and/or accelerated reaction cycles were extremely brief. Seismic cycles or porosity waves represent ephemeral phenomena capable of accounting for development of rhythmic major-element zoning in HP/LT garnet, during subduction, as a result of fluctuations in both P and fluids. Metamorphic rocks may well carry detailed records of the catastrophism that punctuates longer-term tectonometamorphic

Periodic trim solutions with hp-version finite elements in time

NASA Technical Reports Server (NTRS)

Peters, David A.; Hou, Lin-Jun

1990-01-01

Finite elements in time as an alternative strategy for rotorcraft trim problems are studied. The research treats linear flap and linearized flap-lag response both for quasi-trim and trim cases. The connection between Fourier series analysis and hp-finite elements for periodic a problem is also examined. It is proved that Fourier series is a special case of space-time finite elements in which one element is used with a strong displacement formulation. Comparisons are made with respect to accuracy among Fourier analysis, displacement methods, and mixed methods over a variety parameters. The hp trade-off is studied for the periodic trim problem to provide an optimum step size and order of polynomial for a given error criteria. It is found that finite elements in time can outperform Fourier analysis for periodic problems, and for some given error criteria. The mixed method provides better results than does the displacement method.

An hp-adaptivity and error estimation for hyperbolic conservation laws

NASA Technical Reports Server (NTRS)

Bey, Kim S.

1995-01-01

This paper presents an hp-adaptive discontinuous Galerkin method for linear hyperbolic conservation laws. A priori and a posteriori error estimates are derived in mesh-dependent norms which reflect the dependence of the approximate solution on the element size (h) and the degree (p) of the local polynomial approximation. The a posteriori error estimate, based on the element residual method, provides bounds on the actual global error in the approximate solution. The adaptive strategy is designed to deliver an approximate solution with the specified level of error in three steps. The a posteriori estimate is used to assess the accuracy of a given approximate solution and the a priori estimate is used to predict the mesh refinements and polynomial enrichment needed to deliver the desired solution. Numerical examples demonstrate the reliability of the a posteriori error estimates and the effectiveness of the hp-adaptive strategy.

Transportation management center data capture for performance and mobility measures reference manual.

DOT National Transportation Integrated Search

2013-03-01

The Guide to Transportation Management Center (TMC) Data Capture for Performance and Mobility Measures is a two-volume document consisting of a summary Guidebook and this Reference Manual. These documents provide technical guidance and recommended pr...

Strategic Architecture for E-Learning at H.P. University

ERIC Educational Resources Information Center

Sharma, Kunal; Sood, Deepak; Singh, Amarjeet; Pandit, Pallvi

2010-01-01

Purpose: The purpose of the paper is to unravel a strategic architecture for e-learning for a traditional university like Himachal Pradesh University (H.P. University) and provide guidelines as to how to carry the implementation of e-learning for the university of the future. Design/methodology/approach: Getting to the future first is not just…

Chromoplast-Specific Carotenoid-Associated Protein Appears to Be Important for Enhanced Accumulation of Carotenoids in hp1 Tomato Fruits1[C][W][OA

PubMed Central

Kilambi, Himabindu Vasuki; Kumar, Rakesh; Sharma, Rameshwar; Sreelakshmi, Yellamaraju

2013-01-01

Tomato (Solanum lycopersicum) high-pigment mutants with lesions in diverse loci such as DNA Damage-Binding Protein1 (high pigment1 [hp1]), Deetiolated1 (hp2), Zeaxanthin Epoxidase (hp3), and Intense pigment (Ip; gene product unknown) exhibit increased accumulation of fruit carotenoids coupled with an increase in chloroplast number and size. However, little is known about the underlying mechanisms exaggerating the carotenoid accumulation and the chloroplast number in these mutants. A comparison of proteome profiles from the outer pericarp of hp1 mutant and wild-type (cv Ailsa Craig) fruits at different developmental stages revealed at least 72 differentially expressed proteins during ripening. Hierarchical clustering grouped these proteins into three clusters. We found an increased abundance of chromoplast-specific carotenoid-associated protein (CHRC) in hp1 fruits at red-ripe stage that is also reflected in its transcript level. Western blotting using CHRC polyclonal antibody from bell pepper (Capsicum annuum) revealed a 2-fold increase in the abundance of CHRC protein in the red-ripe stage of hp1 fruits compared with the wild type. CHRC levels in hp2 were found to be similar to that of hp1, whereas hp3 and Ip showed intermediate levels to those in hp1, hp2, and wild-type fruits. Both CHRC and carotenoids were present in the isolated plastoglobules. Overall, our results suggest that loss of function of DDB1, DET1, Zeaxanthin Epoxidase, and Ip up-regulates CHRC levels. Increase in CHRC levels may contribute to the enhanced carotenoid content in these high-pigment fruits by assisting in the sequestration and stabilization of carotenoids. PMID:23400702

Microspectroscopic Analysis Of HpD Fluorescence In Bioptic Samples From Human Pre-Malignant And Malignant Lesions Of The Skin

NASA Astrophysics Data System (ADS)

Bottiroli, G.; Dell'Acqua, R.; Jucci, A.; Ricevuti, G.; Sacchi, A. S.

1987-07-01

Microfluorometric analysis was performed on bioptic samples of pre-malignant and malignant cutanous lesions present in the same patients, 48 h after i.v. injection of HpD. Data obtained indicate that actinic keratosis and squamous celle carcinoma show a preferential accumulation if compared to normal skin. The two lesions differ for both intensity and spectral shape of HpD fluorescence. This difference is correlated with a different clinical response to HpD laser phototherapy.

Nektar++: An open-source spectral/ hp element framework

NASA Astrophysics Data System (ADS)

Cantwell, C. D.; Moxey, D.; Comerford, A.; Bolis, A.; Rocco, G.; Mengaldo, G.; De Grazia, D.; Yakovlev, S.; Lombard, J.-E.; Ekelschot, D.; Jordi, B.; Xu, H.; Mohamied, Y.; Eskilsson, C.; Nelson, B.; Vos, P.; Biotto, C.; Kirby, R. M.; Sherwin, S. J.

2015-07-01

Nektar++ is an open-source software framework designed to support the development of high-performance scalable solvers for partial differential equations using the spectral/ hp element method. High-order methods are gaining prominence in several engineering and biomedical applications due to their improved accuracy over low-order techniques at reduced computational cost for a given number of degrees of freedom. However, their proliferation is often limited by their complexity, which makes these methods challenging to implement and use. Nektar++ is an initiative to overcome this limitation by encapsulating the mathematical complexities of the underlying method within an efficient C++ framework, making the techniques more accessible to the broader scientific and industrial communities. The software supports a variety of discretisation techniques and implementation strategies, supporting methods research as well as application-focused computation, and the multi-layered structure of the framework allows the user to embrace as much or as little of the complexity as they need. The libraries capture the mathematical constructs of spectral/ hp element methods, while the associated collection of pre-written PDE solvers provides out-of-the-box application-level functionality and a template for users who wish to develop solutions for addressing questions in their own scientific domains.

Development of an hp-version finite element method for computational optimal control

NASA Technical Reports Server (NTRS)

Hodges, Dewey H.; Warner, Michael S.

1993-01-01

The purpose of this research effort is to develop a means to use, and to ultimately implement, hp-version finite elements in the numerical solution of optimal control problems. The hybrid MACSYMA/FORTRAN code GENCODE was developed which utilized h-version finite elements to successfully approximate solutions to a wide class of optimal control problems. In that code the means for improvement of the solution was the refinement of the time-discretization mesh. With the extension to hp-version finite elements, the degrees of freedom include both nodal values and extra interior values associated with the unknown states, co-states, and controls, the number of which depends on the order of the shape functions in each element.

California Publicly-Owned Utilities (POUs) – LBNL ‘Beyond Widgets’ Project. Task: ambient lighting and occupancy-based plug load control. System Program Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robinson, Alastair; Mathew, Paul A.; Regnier, Cynthia

This program manual contains detailed technical information for implementing an incentive program for task-ambient lighting and occupancy-based plug load control. This manual was developed by Lawrence Berkeley National Laboratory, in collaboration with the California Publicly-Owned Utilities (CA POUs) as a partner in the ‘Beyond Widgets’ program funded by the U.S. Department of Energy Building Technologies Office. The primary audience for this manual is the program staff of the various CA POUs. It may also be used by other utility incentive programs to help develop similar programs. It is anticipated that the content of this manual be utilized by the CAmore » POU staff for developing related documents such as the Technical Resource Manual and other filings pertaining to the rollout of an energy systems-based rebate incentive program.« less

A Technical Assistance Manual on the Employment Provisions (Title 1) of the Americans With Disabilities Act.

ERIC Educational Resources Information Center

Equal Employment Opportunity Commission, Washington, DC.

This manual and resource directory aims to help employers, other entities, and persons with disabilities learn about their obligations and rights under the employment provisions of Title I of the Americans with Disabilities Act (ADA). The manual provides guidance on the application of legal requirements established in the statute and in…

Developing Community-Based Learning Centers for Older Adults. A Technical Assistance Manual.

ERIC Educational Resources Information Center

Sprouse, Betsy M.; Brown, Karen

Designed for community groups and organizations, groups of older adults, senior clubs, and agencies, this manual documents the process of developing community education programs for older adults. The first section introduces the concept of a community learning center, while the second section considers whether a learning center should be…

Solar Simulation Laboratory Description and Manual.

DTIC Science & Technology

1985-06-01

2000 was sent back to Cyborg Corp. three times over a five month period for repairs. The solar lab is presently using a loaner from Cyborg Corp. The IBM...PC/XT is connected to the ISAAC 2000 by a RS232 connection. All programs were written in advanced basic ("BASICA"). BASICA was used because Cyborg ...2067 CH/P Temperature.Control Bath TechnicalManual, November. 1980. A 30. Cyborg Corporation, Version 1.2, IS..AC.....Co..mpiut.er.liz e.d Data

100% Solids Polyurethane Sequestration Coating

DTIC Science & Technology

2014-04-11

Distribution Unlimited 100% Solids Polyurethane Sequestration Coating The views, opinions and/or findings contained in this report are those of the...Papers published in non peer-reviewed journals: 100% Solids Polyurethane Sequestration Coating Report Title Report developed under Topic #CBD13-101...Final Technical Report Contract #: W911NF-13-P-0010 Proposal #: 63958CHSB1 Project: 100% Solids Polyurethane Sequestration Coating

Eudragit RS 100 microparticles containing 2-hydroxypropyl-beta-cyclodextrin and glutathione: physicochemical characterization, drug release and transport studies.

PubMed

Trapani, Adriana; Laquintana, Valentino; Denora, Nunzio; Lopedota, Angela; Cutrignelli, Annalisa; Franco, Massimo; Trapani, Giuseppe; Liso, Gaetano

2007-01-01

The aim of this study was to encapsulate glutathione (GSH) alone or in combination with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in Eudragit RS 100 microparticles (MPs), and to evaluate these novel delivery systems for oral administration of the considered tripeptide. The MPs were prepared by an O/O emulsion-solvent evaporation method according to a multilevel experimental design involving the volume of liquid paraffin, the HP-beta-CD amount, and the drug/polymer ratio as independent variables. The effects of these parameters on particle size, entrapment efficiency, and drug release were investigated. Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) analysis and differential scanning calorimetry (DSC) studies were performed to evaluate possible interactions between GSH and Eudragit RS 100 polymer and to characterize the physical state of drug within the MPs. The release profiles of GSH from MPs were examined in vitro at pH 1.2, 6.8. and 7.4 using the USP III (BioDis) dissolution apparatus. In general, a slow and zero-order release of GSH from MPs at pH 1.2 occurred, while at higher pH values considerable amounts of glutathione disulfide (i.e., GSSG) were observed. The enzymatic stability and the intestinal permeability of some GSH-containing MPs were assessed by using pepsin, alpha-chymotrypsin, gamma-glutamyl-transpeptidase and everted frog intestinal sac methodology, respectively. The results suggest that GSH-loaded Eudragit RS 100 MPs containing HP-beta-CD represent a new sustained GSH delivery system useful for the oral administration of the examined tripeptide.

HpQTL: a geometric morphometric platform to compute the genetic architecture of heterophylly.

PubMed

Sun, Lidan; Wang, Jing; Zhu, Xuli; Jiang, Libo; Gosik, Kirk; Sang, Mengmeng; Sun, Fengsuo; Cheng, Tangren; Zhang, Qixiang; Wu, Rongling

2017-02-15

Heterophylly, i.e. morphological changes in leaves along the axis of an individual plant, is regarded as a strategy used by plants to cope with environmental change. However, little is known of the extent to which heterophylly is controlled by genes and how each underlying gene exerts its effect on heterophyllous variation. We described a geometric morphometric model that can quantify heterophylly in plants and further constructed an R-based computing platform by integrating this model into a genetic mapping and association setting. The platform, named HpQTL, allows specific quantitative trait loci mediating heterophyllous variation to be mapped throughout the genome. The statistical properties of HpQTL were examined and validated via computer simulation. Its biological relevance was demonstrated by results from a real data analysis of heterophylly in a wood plant, mei (Prunus mume). HpQTL provides a powerful tool to analyze heterophylly and its underlying genetic architecture in a quantitative manner. It also contributes a new approach for genome-wide association studies aimed to dissect the programmed regulation of plant development and evolution. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Information Manual: Procedures, Planning Concepts, Subsystems. ABS Publication No. 3.

ERIC Educational Resources Information Center

California Univ., Berkeley.

This report, the third in a series which presents the results of a systems analysis of the problem of providing science and engineering buildings at the university level, is a technical manual for using the Academic Building Systems (ABS) approach in programing, designing, and constructing such facilities. The document presents (1) planning…

Initial development of a device for controlling manually applied forces.

PubMed

Waddington, Gordon S; Adams, Roger D

2007-05-01

In both simulation and manual therapy studies, substantial variability has been shown when therapists attempt to replicate an applied force. Knowledge about the forces employed during treatment could reduce this variability. In the current project, a prototype for a mobilizing device incorporating a dynamometer was constructed. The prototype device was built around a conventional "hand-grip" dynamometer to give dial visibility during application of mobilizing forces and a moulded handle was used to increase the hand contact surface during force application. The variability of the mobilization forces produced was measured, and ratings of comfort during a simulated spinal mobilization technique were obtained from therapists. Thirty physiotherapists were randomly allocated to apply either: (i) their own estimate of a grade III mobilization force using their hands in a pisiform grip or (ii) a 100N force with the manual therapy dynamometer, and to rate comfort during the performance of both techniques on a 100mm visual analogue scale. Variance in dynamometer-dial-guided force application was always significantly less than the variance in therapist-concept-guided force application. Repeated-measures tests showed that the mean force produced at grade III was not significantly different from 100N, but physiotherapist comfort ratings were found to be significantly greater (P<0.01) when the manual therapy dynamometer was used. Manually applied force variability was significantly less and therapist comfort greater when using a device with visual access to a dial giving immediate force readout.

[Preparation of coated tablets of glycyrrhetic acid-HP-beta-cyclodextrin tablets for colon-specific release].

PubMed

Cui, Qi-Hua; Cui, Jing-Hao; Zhang, Jin-Jin

2008-10-01

To prepare coated tablets of glycyrrhetinic acid and hydroxypropyl-beta-cyclodextrin (GTA-HP-beta-CYD) inclusion complex tablets for colon-specific release. In order to improve the solubility of GTA, the GTA-HP-beta-CYD inclusion complex was prepared by ultrasonic-lyophilization technique and its formation were characterized by X-ray powder diffraction profiles and infrared spectrometry. The effects of inclusion condition on the inclusion efficiency and stability coefficient of inclusion complex were investigated, respectively. After prepared GTA-HP-beta-CYD tablets by powder direct compression, the pH dependant polymer Eudragit III and/or mixed with Eudragit II were used for further coating materials in fluid-bed coater. The influences of coating weight on the GTA release in different pH conditions were evaluated to establish the method for prepering colon specific delivery tablets with pulsed release properties. The formation of inclusion complexes were proved by X-ray powder diffraction profile and phase solubility curve. The effect of pH value of solvent was played critical role on the preparation of GTA- HP-beta-CYD inclusion complex. And the inclusion efficiency of GTA was 9. 3% and the solubility was increased to 54. 6 times at optimized method. The Eudragit III coated GTA- HP-beta-CYD tablets with coating weight 10% and 16% were showed pH dependant colon specific release profiles with slow release rate. The release profile of tablets coated with the mixture of Eudragit II and Eudragit III (1:2) were indicated typical pH dependant colon specific and pulsed release properties while the coating weight was 17%. The preliminary method for preparation of colon specific release tablets containing glycyrrhetinic acid with improved solubility was established for further in vivo therapeutic experiment.

Comparison of manual scaled and predicted foE and foF1 critical frequencies. Technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gamache, R.R.; Kersey, W.T.

1990-07-01

The CCIR and Titheridge foE critical frequency prediction routines were tested by comparison with 1875 manually scaled values. The foF1 critical frequency prediction routine of Millman et al was tested by comparison with 1005 manually scaled values. Plots and statistics of the comparisons are presented and discussed. From the results recommendations are made to help improve autoscaling.

Spectrum orbit utilization program technical manual SOUP5 Version 3.8

NASA Technical Reports Server (NTRS)

Davidson, J.; Ottey, H. R.; Sawitz, P.; Zusman, F. S.

1984-01-01

The underlying engineering and mathematical models as well as the computational methods used by the SOUP5 analysis programs, which are part of the R2BCSAT-83 Broadcast Satellite Computational System, are described. Included are the algorithms used to calculate the technical parameters and references to the relevant technical literature. The system provides the following capabilities: requirements file maintenance, data base maintenance, elliptical satellite beam fitting to service areas, plan synthesis from specified requirements, plan analysis, and report generation/query. Each of these functions are briefly described.

Switching the JLab Accelerator Operations Environment from an HP-UX Unix-based to a PC/Linux-based environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mcguckin, Theodore

2008-10-01

The Jefferson Lab Accelerator Controls Environment (ACE) was predominantly based on the HP-UX Unix platform from 1987 through the summer of 2004. During this period the Accelerator Machine Control Center (MCC) underwent a major renovation which included introducing Redhat Enterprise Linux machines, first as specialized process servers and then gradually as general login servers. As computer programs and scripts required to run the accelerator were modified, and inherent problems with the HP-UX platform compounded, more development tools became available for use with Linux and the MCC began to be converted over. In May 2008 the last HP-UX Unix login machinemore » was removed from the MCC, leaving only a few Unix-based remote-login servers still available. This presentation will explore the process of converting an operational Control Room environment from the HP-UX to Linux platform as well as the many hurdles that had to be overcome throughout the transition period (including a discussion of« less

Interplay of Coil–Globule Transition and Surface Adsorption of a Lattice HP Protein Model

PubMed Central

2015-01-01

An end-grafted hydrophobic-polar (HP) model protein chain with alternating H and P monomers is studied to examine interactions between the critical adsorption transition due to surface attraction and the collapse transition due to pairwise attractive H–H interactions. We find that the critical adsorption phenomenon can always be observed; however, the critical adsorption temperature TCAP is influenced by the attractive H–H interactions in some cases. When the collapse temperature Tc is lower than TCAP, the critical adsorption of the HP chain is similar to that of a homopolymer without intrachain attractions and TCAP remains unchanged, whereas the collapse transition is suppressed by the adsorption. In contrast, for cases where Tc is close to or higher than TCAP, TCAP of the HP chain is increased, indicating that a collapsed chain is more easily adsorbed on the surface. The strength of the H–H attraction also influences the statistical size and shape of the polymer, with strong H–H attractions resulting in adsorbed and collapsed chains adopting two-dimensional, circular conformations. PMID:25458556

R&D 100 Awards Demonstrate Clean Energy Legacy - Continuum Magazine |

Science.gov Websites

capable of 1 million billion calculations per second-on Sept. 11, 2013. NREL collaborated with HP and performance and reliability. NREL also won an award in collaboration with HP for the HP Apollo 8000 System, a

Training and Development for Transitional Employment in Mature-Aged Manual Workers

ERIC Educational Resources Information Center

Pillay, Hitendra; Kelly, Kathy; Tones, Megan

2010-01-01

Objectives: The purpose of the current article was to explore perceptions of transitional employment and training and development amongst blue collar workers employed in technical, trade, operations or physical and labour-intensive occupations within the local government system. Methods: The responses of manual workers to two national surveys…

Chromatin Protein HP1α Interacts with the Mitotic Regulator Borealin Protein and Specifies the Centromere Localization of the Chromosomal Passenger Complex*

PubMed Central

Liu, Xing; Song, Zhenwei; Huo, Yuda; Zhang, Jiahai; Zhu, Tongge; Wang, Jianyu; Zhao, Xuannv; Aikhionbare, Felix; Zhang, Jiancun; Duan, Hequan; Wu, Jihui; Dou, Zhen; Shi, Yunyu; Yao, Xuebiao

2014-01-01

Accurate mitosis requires the chromosomal passenger protein complex (CPC) containing Aurora B kinase, borealin, INCENP, and survivin, which orchestrates chromosome dynamics. However, the chromatin factors that specify the CPC to the centromere remain elusive. Here we show that borealin interacts directly with heterochromatin protein 1α (HP1α) and that this interaction is mediated by an evolutionarily conserved PXVXL motif in the C-terminal borealin with the chromo shadow domain of HP1α. This borealin-HP1α interaction recruits the CPC to the centromere and governs an activation of Aurora B kinase judged by phosphorylation of Ser-7 in CENP-A, a substrate of Aurora B. Consistently, modulation of the motif PXVXL leads to defects in CPC centromere targeting and aberrant Aurora B activity. On the other hand, the localization of the CPC in the midzone is independent of the borealin-HP1α interaction, demonstrating the spatial requirement of HP1α in CPC localization to the centromere. These findings reveal a previously unrecognized but direct link between HP1α and CPC localization in the centromere and illustrate the critical role of borealin-HP1α interaction in orchestrating an accurate cell division. PMID:24917673

PULSION® HP: Tunable, High Productivity Plasma Doping

NASA Astrophysics Data System (ADS)

Felch, S. B.; Torregrosa, F.; Etienne, H.; Spiegel, Y.; Roux, L.; Turnbaugh, D.

2011-01-01

Plasma doping has been explored for many implant applications for over two decades and is now being used in semiconductor manufacturing for two applications: DRAM polysilicon counter-doping and contact doping. The PULSION HP is a new plasma doping tool developed by Ion Beam Services for high-volume production that enables customer control of the dominant mechanism—deposition, implant, or etch. The key features of this tool are a proprietary, remote RF plasma source that enables a high density plasma with low chamber pressure, resulting in a wide process space, and special chamber and wafer electrode designs that optimize doping uniformity.

The 300 H.P. Benz Aircraft Engine

NASA Technical Reports Server (NTRS)

Heller, A

1921-01-01

A description is given of the Benz 12-cylinder aircraft engine. The 300 H.P. engine, with the cylinders placed at an angle of 60 degrees not only realizes a long-cherished conception, but has received refinement in detail. It may be described as a perfect example of modern German aircraft engine construction. Here, a detailed description is given of the construction of this engine. Emphasis is placed on the design and construction of the cylinders, pistons, and connecting rods. Also discussed are engine fitting, lubrication, oil pumps, bearings, the oil tank, fuel pump, carburetors, and cooling system.

Detail, unit 4, 3,000 hp synchronous pump motor. Manufactured by ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail, unit 4, 3,000 hp synchronous pump motor. Manufactured by The Electric Products Company, Cleveland, Ohio. Unit 5 is identical to this unit - Wellton-Mohawk Irrigation System, Pumping Plant No. 2, Bounded by Interstate 8 to south, Wellton, Yuma County, AZ

92. DETAIL OF GENERAL ELECTRIC 250HP SYNCHRONOUS MOTOR FROM SLIP ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

92. DETAIL OF GENERAL ELECTRIC 250-HP SYNCHRONOUS MOTOR FROM SLIP RING END. NOTE BOLTS AND SPRINGS OF BRAKE BAND, HEAVY-WIRE ARMATURE WINDINGS, AND TIGHTLY WOUND STATOR (FIELD) COILS. - Shenandoah-Dives Mill, 135 County Road 2, Silverton, San Juan County, CO

Calibration of an eye lens dosemeter in terms of Hp(3) to be used in interventional radiology

NASA Astrophysics Data System (ADS)

Borges, F. L. S.; Guimarães, M. C.; Da Silva, T. A.; Nogueira Tavares, M. S.

2014-11-01

Recently, the International Commission on Radiological Protection has reviewed epidemiological evidences suggesting that there were tissue reaction effects in the eye lens below the previously considered absorbed dose threshold. A new statement related to the eye lens was issued that changed the absorbed dose threshold and reduced the dose limits for occupationally exposed persons. As consequence, some planned exposures require eye lens dosimetry and a debate was raised on the adequacy of the dosimetric quantity and on its method of measurement. The aim of this work was to study the methodology for calibrating the EYE-DTM holder with a TLD-100H Harshaw chip detector and to determine its angular and energy dependences in terms of personal dose equivalent, Hp(3).

Factors increasing the risk of inactivity among administrative, technical, and manual workers in Warszawa public institutions.

PubMed

Biernat, Elżbieta

2015-01-01

The research aims to assess the level of physical activity among administrative, technical, and manual workers employed in Warszawa public institutions and to analyze the factors that increase the risk of failing to meet World Health Organization (WHO) recommendations. The study comprised 373 employees of randomly selected institutions. A short version of International Physical Activity Questionnaire (IPAQ) was applied. The correlation between the mean values of duration, days, MET-min/week of efforts, gender, and type of work was analyzed using the Tukey's honest significant difference (HSD) test, while the correlation between the level of physical activity and the socio-demographic characteristics was assessed with the Chi² test. The strength of the relationship between socio-demographic characteristics and fulfilment of WHO standards was expressed by the odds ratio (OR) and 95% confidence interval (95% CI). The significance level was p = 0.05. High levels of physical activity were declared by 41.8% of the manual workers, 14.7% of the administration staff, and 7.3% of the technicians; 19%, 31.5% and 54.5%, respectively, reported low levels of physical activity. Factors determining the fulfilment of the WHO recommendations include: the nature of work (p = 0.003), education (p = 0.004), and income (p = 0.003). The risk of being inactive nearly doubles in the case of administration staff (31.5%) and increases more than 4 times in the case of technicians (54.5%). Respondents with secondary school education (31.6%) are exposed to a 3-fold higher risk of inactivity, while in respondents with higher education (37.2%), the level of the risk is 4-fold higher. Compared to those in the highest income group (23.4%), people who earn less (34.1%) are inactive almost twice as often. Urgent intervention is necessary in all studied groups: increased energy expenditure for recreation and locomotion, educational offers of employers to promote healthy lifestyle

Whither the White Knight: CDROM in Technical Services.

ERIC Educational Resources Information Center

Campbell, Brian

1987-01-01

Outlines evaluative criteria and compares optical data disk products used in library technical processes, including bibliographic records for cataloging, acquisition databases, and local public access catalogs. An extensive table provides information on specific products, including updates, interfaces, edit screens, installation help, manuals,…

Functional and evolutionary analyses of Helicobacter pylori HP0231 (DsbK) protein with strong oxidative and chaperone activity characterized by a highly diverged dimerization domain

PubMed Central

Bocian-Ostrzycka, Katarzyna M.; Łasica, Anna M.; Dunin-Horkawicz, Stanisław; Grzeszczuk, Magdalena J.; Drabik, Karolina; Dobosz, Aneta M.; Godlewska, Renata; Nowak, Elżbieta; Collet, Jean-Francois; Jagusztyn-Krynicka, Elżbieta K.

2015-01-01

Helicobacter pylori does not encode the classical DsbA/DsbB oxidoreductases that are crucial for oxidative folding of extracytoplasmic proteins. Instead, this microorganism encodes an untypical two proteins playing a role in disulfide bond formation – periplasmic HP0231, which structure resembles that of EcDsbC/DsbG, and its redox partner, a membrane protein HpDsbI (HP0595) with a β-propeller structure. The aim of presented work was to assess relations between HP0231 structure and function. We showed that HP0231 is most closely related evolutionarily to the catalytic domain of DsbG, even though it possesses a catalytic motif typical for canonical DsbA proteins. Similarly, the highly diverged N-terminal dimerization domain is homologous to the dimerization domain of DsbG. To better understand the functioning of this atypical oxidoreductase, we examined its activity using in vivo and in vitro experiments. We found that HP0231 exhibits oxidizing and chaperone activities but no isomerizing activity, even though H. pylori does not contain a classical DsbC. We also show that HP0231 is not involved in the introduction of disulfide bonds into HcpC (Helicobacter cysteine-rich protein C), a protein involved in the modulation of the H. pylori interaction with its host. Additionally, we also constructed a truncated version of HP0231 lacking the dimerization domain, denoted HP0231m, and showed that it acts in Escherichia coli cells in a DsbB-dependent manner. In contrast, HP0231m and classical monomeric EcDsbA (E. coli DsbA protein) were both unable to complement the lack of HP0231 in H. pylori cells, though they exist in oxidized forms. HP0231m is inactive in the insulin reduction assay and possesses high chaperone activity, in contrast to EcDsbA. In conclusion, HP0231 combines oxidative functions characteristic of DsbA proteins and chaperone activity characteristic of DsbC/DsbG, and it lacks isomerization activity. PMID:26500620

Functional and evolutionary analyses of Helicobacter pylori HP0231 (DsbK) protein with strong oxidative and chaperone activity characterized by a highly diverged dimerization domain.

PubMed

Bocian-Ostrzycka, Katarzyna M; Łasica, Anna M; Dunin-Horkawicz, Stanisław; Grzeszczuk, Magdalena J; Drabik, Karolina; Dobosz, Aneta M; Godlewska, Renata; Nowak, Elżbieta; Collet, Jean-Francois; Jagusztyn-Krynicka, Elżbieta K

2015-01-01

Helicobacter pylori does not encode the classical DsbA/DsbB oxidoreductases that are crucial for oxidative folding of extracytoplasmic proteins. Instead, this microorganism encodes an untypical two proteins playing a role in disulfide bond formation - periplasmic HP0231, which structure resembles that of EcDsbC/DsbG, and its redox partner, a membrane protein HpDsbI (HP0595) with a β-propeller structure. The aim of presented work was to assess relations between HP0231 structure and function. We showed that HP0231 is most closely related evolutionarily to the catalytic domain of DsbG, even though it possesses a catalytic motif typical for canonical DsbA proteins. Similarly, the highly diverged N-terminal dimerization domain is homologous to the dimerization domain of DsbG. To better understand the functioning of this atypical oxidoreductase, we examined its activity using in vivo and in vitro experiments. We found that HP0231 exhibits oxidizing and chaperone activities but no isomerizing activity, even though H. pylori does not contain a classical DsbC. We also show that HP0231 is not involved in the introduction of disulfide bonds into HcpC (Helicobacter cysteine-rich protein C), a protein involved in the modulation of the H. pylori interaction with its host. Additionally, we also constructed a truncated version of HP0231 lacking the dimerization domain, denoted HP0231m, and showed that it acts in Escherichia coli cells in a DsbB-dependent manner. In contrast, HP0231m and classical monomeric EcDsbA (E. coli DsbA protein) were both unable to complement the lack of HP0231 in H. pylori cells, though they exist in oxidized forms. HP0231m is inactive in the insulin reduction assay and possesses high chaperone activity, in contrast to EcDsbA. In conclusion, HP0231 combines oxidative functions characteristic of DsbA proteins and chaperone activity characteristic of DsbC/DsbG, and it lacks isomerization activity.

Techniques for predicting high-risk drivers for alcohol countermeasures. Volume 2, User manual

DOT National Transportation Integrated Search

1978-06-01

This user manual, a companion to the Volume I Technical Report by the same name, is designed to aid the alcohol program administrator in his decisions concerning implementation of countermeasures to selected individuals or small groups of drivers. Vo...

22. ASSEMBLY OF 9700 H.P. ALLIS CHALMERS TURBINE, CENTERVILLE P.H. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. ASSEMBLY OF 9700 H.P. ALLIS CHALMERS TURBINE, CENTERVILLE P.H. Drawing no. 50153, traced from Allis Chalmers drawing #699, April 24, 1906. - Centerville Hydroelectric System, Powerhouse, Butte Creek, Centerville, Butte County, CA

SRC-I demonstration plant analytical laboratory methods manual. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klusaritz, M.L.; Tewari, K.C.; Tiedge, W.F.

1983-03-01

This manual is a compilation of analytical procedures required for operation of a Solvent-Refined Coal (SRC-I) demonstration or commercial plant. Each method reproduced in full includes a detailed procedure, a list of equipment and reagents, safety precautions, and, where possible, a precision statement. Procedures for the laboratory's environmental and industrial hygiene modules are not included. Required American Society for Testing and Materials (ASTM) methods are cited, and ICRC's suggested modifications to these methods for handling coal-derived products are provided.

Asphalt Raking. Instructor Manual. Trainee Manual.

ERIC Educational Resources Information Center

Laborers-AGC Education and Training Fund, Pomfret Center, CT.

This packet consists of the instructor and trainee manuals for an asphalt raking course. The instructor manual contains a course schedule for 4 days of instruction, content outline, and instructor outline. The trainee manual is divided into five sections: safety, asphalt basics, placing methods, repair and patching, and clean-up and maintenance.…

Rooftop Unit Comparison Calculator User Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, James D.

This document serves as a user manual for the Packaged rooftop air conditioners and heat pump units comparison calculator (RTUCC) and is an aggregation of the calculator’s website documentation. Content ranges from new-user guide material like the “Quick Start” to the more technical/algorithmic descriptions of the “Methods Pages.” There is also a section listing all the context-help topics that support the features on the “Controls” page. The appendix has a discussion of the EnergyPlus runs that supported the development of the building-response models.

The Weak Link HP-41C hand-held calculator program

Treesearch

Ross A. Phillips; Penn A. Peters; Gary D. Falk

1982-01-01

The Weak Link hand-held calculator program (HP-41C) quickly analyzes a system for logging production and costs. The production equations model conventional chain saw, skidder, loader, and tandemaxle truck operations in eastern mountain areas. Production of each function of the logging system may be determined so that the system may be balanced for minimum cost. The...

Mutation of charged residues to neutral ones accelerates urea denaturation of HP-35.

PubMed

Wei, Haiyan; Yang, Lijiang; Gao, Yi Qin

2010-09-16

Following the studies of urea denaturation of β-hairpins using molecular dynamics, in this paper, molecular dynamics simulations of two peptides, a 35 residue three helix bundle villin headpiece protein HP-35 and its doubly norleucine-substituent mutant (Lys24Nle/Lys29Nle) HP-35 NleNle, were undertaken in urea solutions to understand the molecular mechanism of urea denaturation of α-helices. The mutant HP-35 NleNle was found to denature more easily than the wild type. During the expansion of the small hydrophobic core, water penetration occurs first, followed by that of urea molecules. It was also found that the initial hydration of the peptide backbone is achieved through water hydrogen bonding with the backbone CO groups during the denaturation of both polypeptides. The mutation of the two charged lysine residues to apolar norleucine enhances the accumulation of urea near the hydrophobic core and facilitates the denaturation process. Urea also interacts directly with the peptide backbone as well as side chains, thereby stabilizing nonnative conformations. The mechanism revealed here is consistent with the previous study on secondary structure of β-hairpin polypeptide, GB1, PEPTIDE 1, and TRPZIP4, suggesting that there is a general mechanism in the denaturation of protein backbone hydrogen bonds by urea.

Efficacy, safety and mechanism of HP-β-CD-PEI polymers as absorption enhancers on the intestinal absorption of poorly absorbable drugs in rats.

PubMed

Zhang, Hailong; Huang, Xiaoyan; Zhang, Yongjing; Gao, Yang

2017-03-01

Oral bioavailability of some hydrophilic therapeutic macromolecules was very poor, thus leading to their limited application in clinic. To investigate the efficacy, safety and mechanism of HP-β-CD-PEI polymers on the intestinal absorption of some poorly absorbable drugs in rats. Effects of HP-β-CD-PEI polymers on the intestinal absorptions of drugs were investigated by an in situ closed loop method in rats. The safety of HP-β-CD-PEI polymer was evaluated by measurement of lactate dehydrogenase (LDH) activity and amount of protein released from rat intestinal perfusate. The absorption enhancing mechanisms were explored by the measurement of zeta potential, transepithelial electrical resistance (TEER) and in vitro transport of FD4 (a paracellular marker) across rat intestinal membranes, respectively. HP-β-CD-PEI polymers, especially HP-β-CD-PEI 1800 , demonstrated excellent absorption enhancing effects on drug absorption in a concentration-dependent manner and the enhancing effect was more efficient in the small intestine than that in the large intestine. Five percent (w/v) HP-β-CD-PEI 1800 obviously decreased the TEER, accompanied with increase in the intestinal transport of FD4, indicating that absorption enhancing actions of HP-β-CD-PEI polymers were possibly performed by loosening tight junctions of intestinal epithelium cells, thereby increasing drug permeation via a paracellular pathway. A good liner relationship between absorption enhancing effects of HP-β-CD-PEI polymers and their zeta potentials suggested the contribution of positive charge on the surface of these polymers to their absorption enhancing effects. HP-β-CD-PEI polymers might be potential and safe absorption enhancers for improving oral delivery of poorly absorbable macromolecules including peptides and proteins.

Technical Health Training Manual. Volume 1. Training for Development. Peace Corps Information Collection & Exchange Training Manual No. T-35a.

ERIC Educational Resources Information Center

Clark, Mari; And Others

This manual is designed as a resource for trainers who provide preservice training, either in-country or state-side, to health specialists and generalists assigned to health projects at the community and clinical levels. The training is intended to assist the volunteer in developing knowledge and skill in the areas of primary health care and the…

Technical Health Training Manual. Volume 2. Training for Development. Peace Corps Information Collection & Exchange Training Manual No. T-35a.

ERIC Educational Resources Information Center

Clark, Mari; And Others

This manual is designed as a resource for trainers who provide preservice training, either in-country or state-side, to health specialists and generalists assigned to health projects at the community and clinical levels. The training is intended to assist the volunteer in developing knowledge and skill in the areas of primary health care and the…

Aligning Theme and Information Structure to Improve the Readability of Technical Writing

ERIC Educational Resources Information Center

Moore, N. A. J.

2006-01-01

The readability of technical writing, and technical manuals in particular, especially for second language readers, can be noticeably improved by pairing Theme with Given and Rheme with New. This allows for faster processing of text and easier access to the "method of development" of the text. Typical Theme-Rheme patterns are described, and the…

93. DETAIL OF GENERAL ELECTRIC 250HP SYNCHRONOUS MOTOR FROM DRIVE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

93. DETAIL OF GENERAL ELECTRIC 250-HP SYNCHRONOUS MOTOR FROM DRIVE END. MOTOR BADGE PLATE READS 263 AMP, 400 VOLT, FRAME 6274-D #4940649, 250 HORSEPOWER, TYPE TSR, 3 PHASE, 60 CYCLE, SPEED 300 RPM. - Shenandoah-Dives Mill, 135 County Road 2, Silverton, San Juan County, CO

Analysis of Regolith Properties Using Seismic Signals Generated by InSight's HP3 Penetrator

NASA Astrophysics Data System (ADS)

Kedar, Sharon; Andrade, Jose; Banerdt, Bruce; Delage, Pierre; Golombek, Matt; Grott, Matthias; Hudson, Troy; Kiely, Aaron; Knapmeyer, Martin; Knapmeyer-Endrun, Brigitte; Krause, Christian; Kawamura, Taichi; Lognonne, Philippe; Pike, Tom; Ruan, Youyi; Spohn, Tilman; Teanby, Nick; Tromp, Jeroen; Wookey, James

2017-10-01

InSight's Seismic Experiment for Interior Structure (SEIS) provides a unique and unprecedented opportunity to conduct the first geotechnical survey of the Martian soil by taking advantage of the repeated seismic signals that will be generated by the mole of the Heat Flow and Physical Properties Package (HP3). Knowledge of the elastic properties of the Martian regolith have implications to material strength and can constrain models of water content, and provide context to geological processes and history that have acted on the landing site in western Elysium Planitia. Moreover, it will help to reduce travel-time errors introduced into the analysis of seismic data due to poor knowledge of the shallow subsurface. The challenge faced by the InSight team is to overcome the limited temporal resolution of the sharp hammer signals, which have significantly higher frequency content than the SEIS 100 Hz sampling rate. Fortunately, since the mole propagates at a rate of ˜1 mm per stroke down to 5 m depth, we anticipate thousands of seismic signals, which will vary very gradually as the mole travels. Using a combination of field measurements and modeling we simulate a seismic data set that mimics the InSight HP3-SEIS scenario, and the resolution of the InSight seismometer data. We demonstrate that the direct signal, and more importantly an anticipated reflected signal from the interface between the bottom of the regolith layer and an underlying lava flow, are likely to be observed both by Insight's Very Broad Band (VBB) seismometer and Short Period (SP) seismometer. We have outlined several strategies to increase the signal temporal resolution using the multitude of hammer stroke and internal timing information to stack and interpolate multiple signals, and demonstrated that in spite of the low resolution, the key parameters—seismic velocities and regolith depth—can be retrieved with a high degree of confidence.

Using Functional Flow Diagrams to Enhance Technical Systems Understanding.

ERIC Educational Resources Information Center

Satchwell, Richard E.

1997-01-01

A treatment group of 20 aviation students used training manuals that presented functional flow diagrams before schematic diagrams. Comparison of data from 10 controls on a card-sort task showed that functional flow diagrams enhanced understanding of technical systems. (SK)

Laboratory Manual (For Concrete Instruction Course); Instructor's Guide, Pilot Program Edition.

ERIC Educational Resources Information Center

Portland Cement Association, Cleveland, OH.

This laboratory manual, prepared for a 2-year program in junior colleges and technical institutes, is designed to accompany the instructional materials to train persons for employment as technicians in the cement and concrete industries. Included are 16 laboratory assignments for each of the following: (1) Principles of Concrete, (2) Concrete in…

F100(3) parallel compressor computer code and user's manual

NASA Technical Reports Server (NTRS)

Mazzawy, R. S.; Fulkerson, D. A.; Haddad, D. E.; Clark, T. A.

1978-01-01

The Pratt & Whitney Aircraft multiple segment parallel compressor model has been modified to include the influence of variable compressor vane geometry on the sensitivity to circumferential flow distortion. Further, performance characteristics of the F100 (3) compression system have been incorporated into the model on a blade row basis. In this modified form, the distortion's circumferential location is referenced relative to the variable vane controlling sensors of the F100 (3) engine so that the proper solution can be obtained regardless of distortion orientation. This feature is particularly important for the analysis of inlet temperature distortion. Compatibility with fixed geometry compressor applications has been maintained in the model.

The p and h-p Versions of the Finite Element Method; State of the Art.

DTIC Science & Technology

1986-09-01

the h-p version was first theoretically studied in Babu’ka and Dorr [1981]. For theoretical analy- - sis of the p-version in 3-dimensions, we refer to...1985], Szab6 [1986] and Szab6 [1986a]. The p and h-p versions for two dimensional problems were implemented in the commercial system PROBE by Noetic Tech...approximation for H1 = HI(Q), i.e. we will study the magnitude of Z(K H’(9), S(T,p)). Numerical illustration will be given S., in Section 7. First let

Dynamics simulation on the flexibility and backbone motions of HP1 chromodomain bound to free and lysine 9-methylated histone H3 tails

NASA Astrophysics Data System (ADS)

Jiang, Yanke; Zou, Jianwei; Zeng, Min; Zhang, Na; Yu, Qingsen

Histone methylation has emerged as a central epigenetic modification with both activating and repressive roles in eukaryotic chromatin. Drosophila HP1 (heterochromatin-associated protein 1) is one of the chromodomain proteins that contain the essential aromatic residues as the recognition pocket for lysine methylated histone H3 tail. The aromatic cage indicates that the complex of chromodomain protein binding lysine methylated histone H3 tail can be seen as a typical host-guest system between protein and protein. About 10-ns molecular dynamics simulations have been carried out in this study to examine how the presence of mono-, trimethylated lysine 9 histone H3 tail (Me1K9, Me3K9 H3) influences the motions of HP1 protein receptor. The study shows that the conformation of HP1 protein free of H3 tail easily changes, whereas that of HP1 protein bound to methylated H3 tail does not. But the conformation of inserted Me1K9 H3 changes obviously as the Me1K recognition makes hydrogen-bonded interactions associated with the aromatic cage even more unstable than those in free HP1 protein. The conformational change of Me1K9 H3 is correlated with the motions of HP1 protein. As the recognition factor going from Me1K to Me3K produces a more favorable interaction for aromatic ring, hydrogen-bonded interactions associated with aromatic cage in Me3K9 H3-HP1 complex were observed to be much more stable than those in Me1K9 H3-HP1 complex and free HP1. Because of correlation, the flexibility of Me3K9 H3 decreases. The simulations indicate that both the MeK and the surrounding histone tail sequence are necessary features of recognition which significantly affect the flexibility and backbone motions of HP1 chromodomain. These findings confirm a regulatory mechanism of protein-protein interactions through a trimethylated post-translational modification.

Improved Functional Properties and Efficiencies of Nitinol Wires Under High-Performance Shape Memory Effect (HP-SME)

NASA Astrophysics Data System (ADS)

Casati, R.; Saghafi, F.; Biffi, C. A.; Vedani, M.; Tuissi, A.

2017-10-01

Martensitic Ti-rich NiTi intermetallics are broadly used in various cyclic applications as actuators, which exploit the shape memory effect (SME). Recently, a new approach for exploiting austenitic Ni-rich NiTi shape memory alloys as actuators was proposed and named high-performance shape memory effect (HP-SME). HP-SME is based on thermal recovery of de-twinned martensite produced by mechanical loading of the parent phase. The aim of the manuscript consists in evaluating and comparing the fatigue and actuation properties of austenitic HP-SME wires and conventional martensitic SME wires. The effect of the thermomechanical cycling on the actuation response and the changes in the electrical resistivity of both shape memory materials were studied by performing the actuation tests at different stages of the fatigue life. Finally, the changes in the transition temperatures before and after cycling were also investigated by differential calorimetric tests.

HP LT Variscan metamorphism in the Cubito-Moura schists (Ossa-Morena Zone, southern Iberia)

NASA Astrophysics Data System (ADS)

Booth-Rea, Guillermo; Simancas, José Fernando; Azor, Antonio; Azañón, José Miguel; González-Lodeiro, Francisco; Fonseca, Paulo

2006-12-01

Multi-equilibrium thermobarometry shows that low-grade metapelites (Cubito-Moura schists) from the Ossa-Morena Zone underwent HP-LT metamorphism from 340-370 °C at 1.0-0.9 GPa to 400-450 °C at 0.8-0.7 GPa. These HP-LT equilibriums were reached by parageneses including white K mica, chlorite and chloritoid, which define the earliest schistosity (S 1) in these rocks. The main foliation in the schists is a crenulation cleavage (S 2), which developed during decompression from 0.8-0.7 to 0.4-0.3 GPa at increasing temperatures from 400-450 °C to 440-465 °C. Fe 3+ in chlorite decreased greatly during prograde metamorphism from molar fractions of 0.4 determined in syn-S 1 chlorites down to 0.1 in syn-S 2 chlorites. These new data add to previous findings of eclogites in the Moura schists indicating that a pile of allochtonous rocks situated next to the Beja-Acebuches oceanic amphibolites underwent HP-LT metamorphism during the Variscan orogeny. To cite this article: G. Booth-Rea et al., C. R. Geoscience 338 (2006).

Detail, unit 4, 1,850 horsepower (hp) synchronous pump motor manufactured ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail, unit 4, 1,850 horsepower (hp) synchronous pump motor manufactured by The Electric Products Company, Cleveland , Ohio. Pump units 1, 2, and 3 are identical to this unit. View to the west - Wellton-Mohawk Irrigation System, Pumping Plant No. 3, South of Interstate 8, Wellton, Yuma County, AZ

Measuring Low-PRF Pulsed Signals with a Standard HP 8510B Vector Network Analyzer Within Milliseconds (Het Meten van Lage-PRF Gepulste Signalen met een Standaard HP 8510B Vector Network Analyzer Binnen Enkele Milliseconden)

DTIC Science & Technology

1990-08-01

reference signal 25 5 A METHOD FOR MEASURING LOW-PRF PULSED SIGNALS 28 5.1 Using a NWA with a smaller BPF 28 5.2 Using the HP 8510B external trigger...2nd LO 11Q 3MHz BPF lOkHz BPF Fig. 4: Receiver block diagram The receiver is a double conversion superheterodyne with a 10 kHz wide BandPass Filter... BPF ) in the second IF. This 10 kHz filter is the component that dictates how the HP 8510B responds to pulsed signals. For the pulsed-RF test signal

HP-HMG versus rFSH in treatments combining fresh and frozen IVF cycles: success rates and economic evaluation.

PubMed

Wex-Wechowski, Jaro; Abou-Setta, Ahmed M; Kildegaard Nielsen, Sandy; Kennedy, Richard

2010-08-01

The economic implications of the choice of gonadotrophin influence decision making but their cost-effectiveness in frozen-embryo transfer cycles has not been adequately studied. An economic evaluation was performed comparing highly purified human menopausal gonadotrophin (HP-HMG) and recombinant FSH (rFSH) using individual patient data (n=986) from two large randomized controlled trials using a long agonist IVF protocol. The simulation model incorporated live birth data and published UK costs of IVF-related medical resources. After treatment for up-to-three cycles (one fresh and up to two subsequent fresh or frozen cycles conditional on availability of cryopreserved embryos), the cumulative live birth rate was 53.7% (95% CI 49.3-58.1%) for HP-HMG and 44.6% (40.2-49.0%) for rFSH (OR 1.44, 95% CI 1.12-1.85; P<0.005). The mean costs per IVF treatment for HP-HMG and rFSH were pound5393 ( pound5341-5449) and pound6269 ( pound6210-6324), respectively (number needed to treat to fund one additional treatment was seven; P<0.001). With maternal and neonatal costs applied, the median cost per IVF baby delivered with HP-HMG was pound11,157 ( pound11,089-11,129) and pound14,227 ( pound14,183-14,222) with rFSH (P<0.001). The cost saving using HP-HMG remained after varying model parameters in a probabilistic sensitivity analysis. 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

QRev—Software for computation and quality assurance of acoustic doppler current profiler moving-boat streamflow measurements—Technical manual for version 2.8

USGS Publications Warehouse

Mueller, David S.

2016-06-21

The software program, QRev applies common and consistent computational algorithms combined with automated filtering and quality assessment of the data to improve the quality and efficiency of streamflow measurements and helps ensure that U.S. Geological Survey streamflow measurements are consistent, accurate, and independent of the manufacturer of the instrument used to make the measurement. Software from different manufacturers uses different algorithms for various aspects of the data processing and discharge computation. The algorithms used by QRev to filter data, interpolate data, and compute discharge are documented and compared to the algorithms used in the manufacturers’ software. QRev applies consistent algorithms and creates a data structure that is independent of the data source. QRev saves an extensible markup language (XML) file that can be imported into databases or electronic field notes software. This report is the technical manual for version 2.8 of QRev.

Comparative analysis of the folding dynamics and kinetics of an engineered knotted protein and its variants derived from HP0242 of Helicobacter pylori

NASA Astrophysics Data System (ADS)

Wang, Liang-Wei; Liu, Yu-Nan; Lyu, Ping-Chiang; Jackson, Sophie E.; Hsu, Shang-Te Danny

2015-09-01

Understanding the mechanism by which a polypeptide chain thread itself spontaneously to attain a knotted conformation has been a major challenge in the field of protein folding. HP0242 is a homodimeric protein from Helicobacter pylori with intertwined helices to form a unique pseudo-knotted folding topology. A tandem HP0242 repeat has been constructed to become the first engineered trefoil-knotted protein. Its small size renders it a model system for computational analyses to examine its folding and knotting pathways. Here we report a multi-parametric study on the folding stability and kinetics of a library of HP0242 variants, including the trefoil-knotted tandem HP0242 repeat, using far-UV circular dichroism and fluorescence spectroscopy. Equilibrium chemical denaturation of HP0242 variants shows the presence of highly populated dimeric and structurally heterogeneous folding intermediates. Such equilibrium folding intermediates retain significant amount of helical structures except those at the N- and C-terminal regions in the native structure. Stopped-flow fluorescence measurements of HP0242 variants show that spontaneous refolding into knotted structures can be achieved within seconds, which is several orders of magnitude faster than previously observed for other knotted proteins. Nevertheless, the complex chevron plots indicate that HP0242 variants are prone to misfold into kinetic traps, leading to severely rolled-over refolding arms. The experimental observations are in general agreement with the previously reported molecular dynamics simulations. Based on our results, kinetic folding pathways are proposed to qualitatively describe the complex folding processes of HP0242 variants.

Linking Development Benefits to Neighborhoods: A Manual of Community-Based Strategies. Technical Bulletin.

ERIC Educational Resources Information Center

Casale, Ellen

This manual collects experiences of successful linkage programs to demonstrate the promise of linkage and to show its limits and risks. It is intended to help communities assess the capacity of linkage to meet their needs and evaluate the considerable commitment this strategy requires. (In linkage programs, developers who receive community…

Iowa Bridge Backwater Software : users manual IHRB TR-564, version 2.0, June 2010.

DOT National Transportation Integrated Search

2010-06-01

This manual describes how to use the Iowa Bridge Backwater software. It also documents the methods and equations used for the calculations. The main body describes how to use the software and the appendices cover technical aspects. : The Bridge Backw...

HP-9810A calculator programs for plotting the 2-dimensional motion of cyclindrical payloads relative to the shuttle orbiter

NASA Technical Reports Server (NTRS)

Wilson, S. W.

1976-01-01

The HP-9810A calculator programs described provide the capability to generate HP-9862A plotter displays which depict the apparent motion of a free-flying cyclindrical payload relative to the shuttle orbiter body axes by projecting the payload geometry into the orbiter plane of symmetry at regular time intervals.

Load research manual. Volume 1. Load research procedures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandenburg, L.; Clarkson, G.; Grund, Jr., C.

1980-11-01

This three-volume manual presents technical guidelines for electric utility load research. Special attention is given to issues raised by the load data reporting requirements of the Public Utility Regulatory Policies Act of 1978 and to problems faced by smaller utilities that are initiating load research programs. In Volumes 1 and 2, procedures are suggested for determining data requirements for load research, establishing the size and customer composition of a load survey sample, selecting and using equipment to record customer electricity usage, processing data tapes from the recording equipment, and analyzing the data. Statistical techniques used in customer sampling are discussedmore » in detail. The costs of load research also are estimated, and ongoing load research programs at three utilities are described. The manual includes guides to load research literature and glossaries of load research and statistical terms.« less

Determination of the heat of hydride formation/decomposition by high-pressure differential scanning calorimetry (HP-DSC).

PubMed

Rongeat, Carine; Llamas-Jansa, Isabel; Doppiu, Stefania; Deledda, Stefano; Borgschulte, Andreas; Schultz, Ludwig; Gutfleisch, Oliver

2007-11-22

Among the thermodynamic properties of novel materials for solid-state hydrogen storage, the heat of formation/decomposition of hydrides is the most important parameter to evaluate the stability of the compound and its temperature and pressure of operation. In this work, the desorption and absorption behaviors of three different classes of hydrides are investigated under different hydrogen pressures using high-pressure differential scanning calorimetry (HP-DSC). The HP-DSC technique is used to estimate the equilibrium pressures as a function of temperature, from which the heat of formation is derived. The relevance of this procedure is demonstrated for (i) magnesium-based compounds (Ni-doped MgH2), (ii) Mg-Co-based ternary hydrides (Mg-CoHx) and (iii) Alanate complex hydrides (Ti-doped NaAlH4). From these results, it can be concluded that HP-DSC is a powerful tool to obtain a good approximation of the thermodynamic properties of hydride compounds by a simple and fast study of desorption and absorption properties under different pressures.

Educational Personnel Needs Assessment: CSPD Technical Manual, 1989. Critical Areas of Data Collection.

ERIC Educational Resources Information Center

Lauritzen, Paul

This manual addresses the Comprehensive System of Personnel Development (CSPD) requirement of Public Law 94-142. It presents model procedures for the collection of data necessary to project personnel needs in special education. Implementation of the model will identify: areas of education which show need for additional teachers as well as areas of…

29. INDUCTION MOTOR (6600 VOLTS, 5750 H.P.) DRIVES THE 21INCH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. INDUCTION MOTOR (6600 VOLTS, 5750 H.P.) DRIVES THE 21-INCH AND 18-INCH BILLET MILLS. MOTOR WAS MANUFACTURED BY THE GENERAL ELECTRIC COMPANY, SCHENECTADY, NEW YORK. - Corrigan, McKinney Steel Company, 3100 East Forty-fifth Street, Cleveland, Cuyahoga County, OH

A new computer-based Farnsworth Munsell 100-hue test for evaluation of color vision.

PubMed

Ghose, Supriyo; Parmar, Twinkle; Dada, Tanuj; Vanathi, Murugesan; Sharma, Sourabh

2014-08-01

To evaluate a computer-based Farnsworth-Munsell (FM) 100-hue test and compare it with a manual FM 100-hue test in normal and congenital color-deficient individuals. Fifty color defective subjects and 200 normal subjects with a best-corrected visual acuity ≥ 6/12 were compared using a standard manual FM 100-hue test and a computer-based FM 100-hue test under standard operating conditions as recommended by the manufacturer after initial trial testing. Parameters evaluated were total error scores (TES), type of defect and testing time. Pearson's correlation coefficient was used to determine the relationship between the test scores. Cohen's kappa was used to assess agreement of color defect classification between the two tests. A receiver operating characteristic curve was used to determine the optimal cut-off score for the computer-based FM 100-hue test. The mean time was 16 ± 1.5 (range 6-20) min for the manual FM 100-hue test and 7.4 ± 1.4 (range 5-13) min for the computer-based FM 100-hue test, thus reducing testing time to <50 % (p < 0.05). For grading color discrimination, Pearson's correlation coefficient for TES between the two tests was 0.91 (p < 0.001). For color defect classification, Cohen's agreement coefficient was 0.98 (p < 0.01). The computer-based FM 100-hue is an effective and rapid method for detecting, classifying and grading color vision anomalies.

Flight dynamics analysis and simulation of heavy lift airships. Volume 2: Technical manual

NASA Technical Reports Server (NTRS)

Ringland, R. F.; Tischler, M. B.; Jex, H. R.; Emmen, R. D.; Ashkenas, I. L.

1982-01-01

The mathematical models embodied in the simulation are described in considerable detail and with supporting evidence for the model forms chosen. In addition the trimming and linearization algorithms used in the simulation are described. Appendices to the manual identify reference material for estimating the needed coefficients for the input data and provide example simulation results.

Heat Pipe Reactor Dynamic Response Tests: SAFE-100 Reactor Core Prototype

NASA Technical Reports Server (NTRS)

Bragg-Sitton, Shannon M.

2005-01-01

The SAFE-I00a test article at the NASA Marshall Space Flight Center was used to simulate a variety of potential reactor transients; the SAFEl00a is a resistively heated, stainless-steel heat-pipe (HP)-reactor core segment, coupled to a gas-flow heat exchanger (HX). For these transients the core power was controlled by a point kinetics model with reactivity feedback based on core average temperature; the neutron generation time and the temperature feedback coefficient are provided as model inputs. This type of non-nuclear test is expected to provide reasonable approximation of reactor transient behavior because reactivity feedback is very simple in a compact fast reactor (simple, negative, and relatively monotonic temperature feedback, caused mostly by thermal expansion) and calculations show there are no significant reactivity effects associated with fluid in the HP (the worth of the entire inventory of Na in the core is .100 tests, the point kinetics model was based on core thermal expansion via deflection measurements. It was found that core deflection was a strung function of how the SAFE-100 modules were fabricated and assembled (in terms of straightness, gaps, and other tolerances). To remove the added variable of how this particular core expands as compared to a different concept, it was decided to use a temperature based feedback model (based on several thermocouples placed throughout the core).

Oral Immunization with Recombinant Lactobacillus acidophilus Expressing the Adhesin Hp0410 of Helicobacter pylori Induces Mucosal and Systemic Immune Responses

PubMed Central

Hongying, Fan; Xianbo, Wu; Fang, Yu; Yang, Bai

2014-01-01

Helicobacter pylori infection is relatively common worldwide and is closely related to gastric mucosa-associated lymphoid tissue (MALT) lymphoma, chronic gastritis, and stomach ulcers. Therefore, a safe and effective method for preventing H. pylori infection is urgently needed. Given that developing an effective vaccine against H. pylori is one of the best alternatives, H. pylori adhesin Hp0410 was expressed in the food-grade bacterium Lactobacillus acidophilus. The recombinant live bacterial vaccine was then used to orally vaccinate mice, and the immunoprotective effects of Hp0410-producing strains were investigated. H. pylori colonization in the stomach of mice immunized with the recombinant L. acidophilus was significantly reduced, in comparison with that in control groups. Furthermore, mucosal secretory IgA antibodies were elicited in the mucosal tissue of mice immunized with the recombinant bacteria, and specific anti-Hp0410 IgG responses were also detected in mouse serum. There was a significant increase in the level of protection against gastric Helicobacter infection following a challenge with H. pylori Sydney strain 1 (SS1). Our results collectively indicate that adhesin Hp0410 is a promising candidate vaccine antigen, and recombinant L. acidophilus expressing Hp0410 is likely to constitute an effective, low-cost, live bacterial vaccine against H. pylori. PMID:24285819

Development of an hp-version finite element method for computational optimal control

NASA Technical Reports Server (NTRS)

Hodges, Dewey H.; Warner, Michael S.

1993-01-01

The purpose of this research effort was to begin the study of the application of hp-version finite elements to the numerical solution of optimal control problems. Under NAG-939, the hybrid MACSYMA/FORTRAN code GENCODE was developed which utilized h-version finite elements to successfully approximate solutions to a wide class of optimal control problems. In that code the means for improvement of the solution was the refinement of the time-discretization mesh. With the extension to hp-version finite elements, the degrees of freedom include both nodal values and extra interior values associated with the unknown states, co-states, and controls, the number of which depends on the order of the shape functions in each element. One possible drawback is the increased computational effort within each element required in implementing hp-version finite elements. We are trying to determine whether this computational effort is sufficiently offset by the reduction in the number of time elements used and improved Newton-Raphson convergence so as to be useful in solving optimal control problems in real time. Because certain of the element interior unknowns can be eliminated at the element level by solving a small set of nonlinear algebraic equations in which the nodal values are taken as given, the scheme may turn out to be especially powerful in a parallel computing environment. A different processor could be assigned to each element. The number of processors, strictly speaking, is not required to be any larger than the number of sub-regions which are free of discontinuities of any kind.

Crystallography and Morphology of MC Carbides in Niobium-Titanium Modified As-Cast HP Alloys

NASA Astrophysics Data System (ADS)

Buchanan, Karl G.; Kral, Milo V.; Bishop, Catherine M.

2014-07-01

The microstructures of two as-cast heats of HP alloy stainless steels modified with niobium and titanium were examined with particular attention paid to the interdendritic niobium-titanium-rich carbides formed during solidification of these alloys. Generally, these precipitates obtain a blocky morphology in the as-cast condition. However, the (NbTi)C precipitates may obtain a nodular morphology. To provide further insight to the origin of the two different morphologies obtained by the (NbTi)C precipitates in the HP-NbTi alloy, the microstructure and crystallography of each have been studied in detail using scanning electron microscopy, transmission electron microscopy, various electron diffraction methods (EBSD, SAD, and CBED), and energy-dispersive X-ray spectroscopy.

A nonlinear HP-type complementary resistive switch

NASA Astrophysics Data System (ADS)

Radtke, Paul K.; Schimansky-Geier, Lutz

2016-05-01

Resistive Switching (RS) is the change in resistance of a dielectric under the influence of an external current or electric field. This change is non-volatile, and the basis of both the memristor and resistive random access memory. In the latter, high integration densities favor the anti-serial combination of two RS-elements to a single cell, termed the complementary resistive switch (CRS). Motivated by the irregular shape of the filament protruding into the device, we suggest a nonlinearity in the resistance-interpolation function, characterized by a single parameter p. Thereby the original HP-memristor is expanded upon. We numerically simulate and analytically solve this model. Further, the nonlinearity allows for its application to the CRS.

Modeling of heterogeneous elastic materials by the multiscale hp-adaptive finite element method

NASA Astrophysics Data System (ADS)

Klimczak, Marek; Cecot, Witold

2018-01-01

We present an enhancement of the multiscale finite element method (MsFEM) by combining it with the hp-adaptive FEM. Such a discretization-based homogenization technique is a versatile tool for modeling heterogeneous materials with fast oscillating elasticity coefficients. No assumption on periodicity of the domain is required. In order to avoid direct, so-called overkill mesh computations, a coarse mesh with effective stiffness matrices is used and special shape functions are constructed to account for the local heterogeneities at the micro resolution. The automatic adaptivity (hp-type at the macro resolution and h-type at the micro resolution) increases efficiency of computation. In this paper details of the modified MsFEM are presented and a numerical test performed on a Fichera corner domain is presented in order to validate the proposed approach.

Verification tests of the U. S. Electricar Corporation Lectric Leopard. Technical report 3 Aug-25 Sep 81

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dowgiallo, E.J. Jr; Snellings, I.R.; Chapman, R.D.

1982-04-01

The Lectric Leopard manufactured by U.S. Electricar Corporation was tested at MERADCOM as part of the Department of Energy project to verify conformity to performance standards of electric vehicles. The Leopard is a standard Fiat Strada sedan which has been converted to an electric vehicle. It is powered by 16 6-V batteries through a silicon-controlled rectifier (SCR) Controller to a 23-hp series-wound d.c. motor. It is equipped with a five-speed manual transmission, power-assisted disc brakes in the front and drum brakes in the rear. It is not equipped with regenerative braking.

Cross-Validation of the Spanish HP-Version of the Jefferson Scale of Empathy Confirmed with Some Cross-Cultural Differences.

PubMed

Alcorta-Garza, Adelina; San-Martín, Montserrat; Delgado-Bolton, Roberto; Soler-González, Jorge; Roig, Helena; Vivanco, Luis

2016-01-01

Medical educators agree that empathy is essential for physicians' professionalism. The Health Professional Version of the Jefferson Scale of Empathy (JSE-HP) was developed in response to a need for a psychometrically sound instrument to measure empathy in the context of patient care. Although extensive support for its validity and reliability is available, the authors recognize the necessity to examine psychometrics of the JSE-HP in different socio-cultural contexts to assure the psychometric soundness of this instrument. The first aim of this study was to confirm its psychometric properties in the cross-cultural context of Spain and Latin American countries. The second aim was to measure the influence of social and cultural factors on the development of medical empathy in health practitioners. The original English version of the JSE-HP was translated into International Spanish using back-translation procedures. The Spanish version of the JSE-HP was administered to 896 physicians from Spain and 13 Latin American countries. Data were subjected to exploratory factor analysis using principal component analysis (PCA) with oblique rotation (promax) to allow for correlation among the resulting factors, followed by a second analysis, using confirmatory factor analysis (CFA). Two theoretical models, one based on the English JSE-HP and another on the first Spanish student version of the JSE (JSE-S), were tested. Demographic variables were compared using group comparisons. A total of 715 (80%) surveys were returned fully completed. Cronbach's alpha coefficient of the JSE for the entire sample was 0.84. The psychometric properties of the Spanish JSE-HP matched those of the original English JSE-HP. However, the Spanish JSE-S model proved more appropriate than the original English model for the sample in this study. Group comparisons among physicians classified by gender, medical specialties, cultural and cross-cultural backgrounds yielded statistically significant differences

Scoring the home falls and accidents screening tool for health professionals (HOME FAST-HP): Evidence from one epidemiological study.

PubMed

Mackenzie, Lynette; Byles, Julie

2018-03-30

Falls in older people are a major public health concern. To target falls prevention interventions, screening tools need to be able to identify older people at greater risk of falling. This study aimed to investigate the screening capacity of the Home Falls and Accidents Screening Tool for health professionals (HOME FAST-HP), and to identify the best cut-off score to identify older people at higher risk of falls using the HOME FAST-HP. The study used cross-sectional data from a random sample of 650 women from the 1921 to 1926 cohort of the Australian Longitudinal Study of Women's Health (ALSWH). Selected women were sent a postal survey including the HOME FAST-HP, falls history, and other health factors. Scores on the home fast were calculated and the cut-point for optimal sensitivity and specificity of the HOME FAST-HP in relation to falls was assessed using a Receiver Operating Characteristic curve. A total of 567 older women participated (response rate 87%). The mean age of participants was 77.5 yrs (95% CI 77.31-77.70). A total of 153 participants (27%) reported a fall in the previous six months. The mean number of hazards using the HOME FAST-HP was 9.74 (95% CI 9.48-10.01), range 2-22. Non-fallers had a mean of 9.6 hazards (95% CI 9.32-9.91) and fallers had a mean of 10.63 hazards (95% CI 10.08-11.19) which was a significant difference (t = 3.41, P = 0.001). The area under the receiver operator curve (AUC) was 0.58 (95% CI 0.53-0.64). A HOME FAST-HP cut-off score of 9 was associated with the optimal sensitivity for falls (73.9%), with specificity (37.9%), and positive predictive value was 30.6% and negative predictive value was 79.7%. The HOME FAST-HP can be used as a screening tool to identify fallers with a cut-off score of nine indicating a higher risk of falling. © 2018 Occupational Therapy Australia.

Cross-Validation of the Spanish HP-Version of the Jefferson Scale of Empathy Confirmed with Some Cross-Cultural Differences

PubMed Central

Alcorta-Garza, Adelina; San-Martín, Montserrat; Delgado-Bolton, Roberto; Soler-González, Jorge; Roig, Helena; Vivanco, Luis

2016-01-01

Context: Medical educators agree that empathy is essential for physicians' professionalism. The Health Professional Version of the Jefferson Scale of Empathy (JSE-HP) was developed in response to a need for a psychometrically sound instrument to measure empathy in the context of patient care. Although extensive support for its validity and reliability is available, the authors recognize the necessity to examine psychometrics of the JSE-HP in different socio-cultural contexts to assure the psychometric soundness of this instrument. The first aim of this study was to confirm its psychometric properties in the cross-cultural context of Spain and Latin American countries. The second aim was to measure the influence of social and cultural factors on the development of medical empathy in health practitioners. Methods: The original English version of the JSE-HP was translated into International Spanish using back-translation procedures. The Spanish version of the JSE-HP was administered to 896 physicians from Spain and 13 Latin American countries. Data were subjected to exploratory factor analysis using principal component analysis (PCA) with oblique rotation (promax) to allow for correlation among the resulting factors, followed by a second analysis, using confirmatory factor analysis (CFA). Two theoretical models, one based on the English JSE-HP and another on the first Spanish student version of the JSE (JSE-S), were tested. Demographic variables were compared using group comparisons. Results: A total of 715 (80%) surveys were returned fully completed. Cronbach's alpha coefficient of the JSE for the entire sample was 0.84. The psychometric properties of the Spanish JSE-HP matched those of the original English JSE-HP. However, the Spanish JSE-S model proved more appropriate than the original English model for the sample in this study. Group comparisons among physicians classified by gender, medical specialties, cultural and cross-cultural backgrounds yielded

Mantle wedge exhumation beneath the Dora-Maira (U)HP dome unravelled by local earthquake tomography (Western Alps)

NASA Astrophysics Data System (ADS)

Solarino, Stefano; Malusà, Marco G.; Eva, Elena; Guillot, Stéphane; Paul, Anne; Schwartz, Stéphane; Zhao, Liang; Aubert, Coralie; Dumont, Thierry; Pondrelli, Silvia; Salimbeni, Simone; Wang, Qingchen; Xu, Xiaobing; Zheng, Tianyu; Zhu, Rixiang

2018-01-01

In continental subduction zones, the behaviour of the mantle wedge during exhumation of (ultra)high-pressure [(U)HP] rocks provides a key to distinguish among competing exhumation mechanisms. However, in spite of the relevant implications for understanding orogenic evolution, a high-resolution image of the mantle wedge beneath the Western Alps is still lacking. In order to fill this gap, we perform a detailed analysis of the velocity structure of the Alpine belt beneath the Dora-Maira (U)HP dome, based on local earthquake tomography independently validated by receiver function analysis. Our results point to a composite structure of the mantle wedge above the subducted European lithosphere. We found that the Dora-Maira (U)HP dome lays directly above partly serpentinized peridotites (Vp 7.5 km/s; Vp/Vs = 1.70-1.72), documented from 10 km depth down to the top of the eclogitized lower crust of the European plate. These serpentinized peridotites, possibly formed by fluid release from the subducting European slab to the Alpine mantle wedge, are juxtaposed against dry mantle peridotites of the Adriatic upper plate along an active fault rooted in the lithospheric mantle. We propose that serpentinized mantle-wedge peridotites were exhumed at shallow crustal levels during late Eocene transtensional tectonics, also triggering the rapid exhumation of (U)HP rocks, and were subsequently indented under the Alpine metamorphic wedge in the early Oligocene. Our findings suggest that mantle-wedge exhumation may represent a major feature of the deep structure of exhumed continental subduction zones. The deep orogenic levels here imaged by seismic tomography may be exposed today in older (U)HP belts, where mantle-wedge serpentinites are commonly associated with coesite-bearing continental metamorphic rocks.

Development of iPad application "Postima" for quantitative analysis of the effects of manual therapy

NASA Astrophysics Data System (ADS)

Sugiyama, Naruhisa; Shirakawa, Tomohiro

2017-07-01

The technical difficulty of diagnosing joint misalignment and/or dysfunction by quantitative evaluation is commonly acknowledged among manual therapists. Usually, manual therapists make a diagnosis based on a combination of observing patient symptoms and performing physical examinations, both of which rely on subjective criteria and thus contain some uncertainty. We thus sought to investigate the correlations among posture, skeletal misalignment, and pain severity over the course of manual therapy treatment, and to explore the possibility of establishing objective criteria for diagnosis. For this purpose, we developed an iPad application that realizes the measurement of patients' postures and analyzes them quantitatively. We also discuss the results and effectiveness of the measurement and analysis.

Technical Manual for the SAM Physical Trough Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagner, M. J.; Gilman, P.

2011-06-01

NREL, in conjunction with Sandia National Lab and the U.S Department of Energy, developed the System Advisor Model (SAM) analysis tool for renewable energy system performance and economic analysis. This paper documents the technical background and engineering formulation for one of SAM's two parabolic trough system models in SAM. The Physical Trough model calculates performance relationships based on physical first principles where possible, allowing the modeler to predict electricity production for a wider range of component geometries than is possible in the Empirical Trough model. This document describes the major parabolic trough plant subsystems in detail including the solar field,more » power block, thermal storage, piping, auxiliary heating, and control systems. This model makes use of both existing subsystem performance modeling approaches, and new approaches developed specifically for SAM.« less

Oral Rehydration Therapy and the Control of Diarrheal Diseases. Training for Development. Peace Corps Information Collection & Exchange Training Manual No. T-34.

ERIC Educational Resources Information Center

Clark, Mari; And Others

This manual was developed to train Peace Corps volunteers and other community health workers in oral rehydration therapy (ORT) and the control of diarrheal diseases. Using a competency-based format, the manual contains six training modules (organized in 22 sessions) that focus on interrelated health education and technical content areas. Each…

Assessment of reproductive and developmental effects of DINP, DnHP and DCHP using quantitative weight of evidence.

PubMed

Dekant, Wolfgang; Bridges, James

2016-11-01

Quantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores for quality and observed toxicity. This QWoE-methodology was applied to the reproductive toxicity data on diisononylphthalate (DINP), di-n-hexylphthalate (DnHP), and dicyclohexylphthalate (DCHP) to determine if the scientific evidence for adverse effects meets the requirements for classification as reproductive toxicants. The scores for DINP were compared to those when applying the methodology DCHP and DnHP that have harmonized classifications. Based on the quality/reliability scores, application of the QWoE shows that the three databases are of similar quality; but effect scores differ widely. Application of QWoE to DINP studies resulted in an overall score well below the benchmark required to trigger classification. For DCHP, the QWoE also results in low scores. The high scores from the application of the QWoE methodology to the toxicological data for DnHP represent clear evidence for adverse effects and justify a classification of DnHP as category 1B for both development and fertility. The conclusions on classification based on the QWoE are well supported using a narrative assessment of consistency and biological plausibility. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Comparison of Cobas 6500 and Iris IQ200 fully-automated urine analyzers to manual urine microscopy

PubMed Central

Bakan, Ebubekir; Ozturk, Nurinnisa; Baygutalp, Nurcan Kilic; Polat, Elif; Akpinar, Kadriye; Dorman, Emrullah; Polat, Harun; Bakan, Nuri

2016-01-01

Introduction Urine screening is achieved by either automated or manual microscopic analysis. The aim of the study was to compare Cobas 6500 and Iris IQ200 urine analyzers, and manual urine microscopic analysis. Materials and methods A total of 540 urine samples sent to the laboratory for chemical and sediment analysis were analyzed on Cobas 6500 and Iris IQ200 within 1 hour from sampling. One hundred and fifty three samples were found to have pathological sediment results and were subjected to manual microscopic analysis performed by laboratory staff blinded to the study. Spearman’s and Gamma statistics were used for correlation analyses, and the McNemar test for the comparison of the two automated analyzers. Results The comparison of Cobas u701 to the manual method yielded the following regression equations: y = - 0.12 (95% CI: - 1.09 to 0.67) + 0.78 (95% CI: 0.65 to 0.95) x for WBC and y = 0.06 (95% CI: - 0.09 to 0.25) + 0.66 (95% CI: 0.57 to 0.73) x for RBC. The comparison of IQ200 Elite to manual method the following equations: y = 0.03 (95% CI: - 1.00 to 1.00) + 0.88 (95% CI: 0.66 to 1.00) x for WBC and y = - 0.22 (95% CI: - 0.80 to 0.20) + 0.40 (95% CI: 0.32 to 0.50) x for RBC. IQ200 Elite compared to Cobas u701 yielded the following equations: y = - 0.95 (95% CI: - 2.13 to 0.11) + 1.25 (95% CI: 1.08 to 1.44) x for WBC and y = - 1.20 (95% CI: - 1.80 to -0.30) + 0. 80 (95% CI: 0.55 to 1.00) x for RBC. Conclusions The two analyzers showed similar performances and good compatibility to manual microscopy. However, they are still inadequate in the determination of WBC, RBC, and EC in highly-pathological samples. Thus, confirmation by manual microscopic analysis may be useful. PMID:27812305

Tinker-HP: a massively parallel molecular dynamics package for multiscale simulations of large complex systems with advanced point dipole polarizable force fields.

PubMed

Lagardère, Louis; Jolly, Luc-Henri; Lipparini, Filippo; Aviat, Félix; Stamm, Benjamin; Jing, Zhifeng F; Harger, Matthew; Torabifard, Hedieh; Cisneros, G Andrés; Schnieders, Michael J; Gresh, Nohad; Maday, Yvon; Ren, Pengyu Y; Ponder, Jay W; Piquemal, Jean-Philip

2018-01-28

We present Tinker-HP, a massively MPI parallel package dedicated to classical molecular dynamics (MD) and to multiscale simulations, using advanced polarizable force fields (PFF) encompassing distributed multipoles electrostatics. Tinker-HP is an evolution of the popular Tinker package code that conserves its simplicity of use and its reference double precision implementation for CPUs. Grounded on interdisciplinary efforts with applied mathematics, Tinker-HP allows for long polarizable MD simulations on large systems up to millions of atoms. We detail in the paper the newly developed extension of massively parallel 3D spatial decomposition to point dipole polarizable models as well as their coupling to efficient Krylov iterative and non-iterative polarization solvers. The design of the code allows the use of various computer systems ranging from laboratory workstations to modern petascale supercomputers with thousands of cores. Tinker-HP proposes therefore the first high-performance scalable CPU computing environment for the development of next generation point dipole PFFs and for production simulations. Strategies linking Tinker-HP to Quantum Mechanics (QM) in the framework of multiscale polarizable self-consistent QM/MD simulations are also provided. The possibilities, performances and scalability of the software are demonstrated via benchmarks calculations using the polarizable AMOEBA force field on systems ranging from large water boxes of increasing size and ionic liquids to (very) large biosystems encompassing several proteins as well as the complete satellite tobacco mosaic virus and ribosome structures. For small systems, Tinker-HP appears to be competitive with the Tinker-OpenMM GPU implementation of Tinker. As the system size grows, Tinker-HP remains operational thanks to its access to distributed memory and takes advantage of its new algorithmic enabling for stable long timescale polarizable simulations. Overall, a several thousand-fold acceleration over

Fiscal Year 1986 Technical Objective Document (TOD).

DTIC Science & Technology

1986-03-01

abilties superior to other IR and manual turrets. - START DATE: FY 88 END DATE: FY 90" PROJECT TITLE: COMPOSITE METAL FIRES EE 62:06 JON: 2673XXXX...TECHNOLOGY: FIRE ELEMENT: INTERACTION DESCRIPTION (TECHNICAL OBJECTIVE) Evaluate a new series of agents "BORALONS" capable of extinguishing metal fires and...PROJECT TITLE: COMPOSITE METAL FIRES PE: 63723 JON: 2104XXXX

KIVA-hpFE. Predictive turbulent reactive and multiphase flow in engines - An Overview

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carrington, David Bradley

2016-05-23

Research and development of KIVA-hpFE for turbulent reactive and multiphase flow particularly as related to engine modeling program has relevance to National energy security and climate change. Climate change is a source problem, and energy national security is consumption of petroleum products problem. Accurately predicting engine processes leads to, lower greenhouse gas (GHG) emission, where engines in the transportation sector currently account for 26% of the U.S. GHG emissions. Less dependence on petroleum products leads to greater energy security. By Environmental Protection Agency standards, some vehicles are now reaching 42 to the 50 mpg mark. These are conventional gasoline engines.more » Continued investment and research into new technical innovations, the potential exists to save more than 4 million barrels of oil per day or approximately $200 to $400 million per day. This would be a significant decrease in emission and use of petroleum and a very large economic stimulus too! It is estimated with further advancements in combustion, the current emissions can be reduced up to 40%. Enabling better understanding of fuel injection and fuel-air mixing, thermodynamic combustion losses, and combustion/emission formation processes enhances our ability to help solve both problems. To provide adequate capability for accurately simulating these processes, minimize time and labor for development of engine technology, are the goals of our KIVA development program.« less

Assessment of four calculation methods proposed by the EC for waste hazardous property HP 14 'Ecotoxic'.

PubMed

Hennebert, Pierre; Humez, Nicolas; Conche, Isabelle; Bishop, Ian; Rebischung, Flore

2016-02-01

Legislation published in December 2014 revised both the List of Waste (LoW) and amended Appendix III of the revised Waste Framework Directive 2008/98/EC; the latter redefined hazardous properties HP 1 to HP 13 and HP 15 but left the assessment of HP 14 unchanged to allow time for the Directorate General of the Environment of the European Commission to complete a study that is examining the impacts of four different calculation methods for the assessment of HP 14. This paper is a contribution to the assessment of the four calculation methods. It also includes the results of a fifth calculation method; referred to as "Method 2 with extended M-factors". Two sets of data were utilised in the assessment; the first (Data Set #1) comprised analytical data for 32 different waste streams (16 hazardous (H), 9 non-hazardous (NH) and 7 mirror entries, as classified by the LoW) while the second data set (Data Set #2), supplied by the eco industries, comprised analytical data for 88 waste streams, all classified as hazardous (H) by the LoW. Two approaches were used to assess the five calculation methods. The first approach assessed the relative ranking of the five calculation methods by the frequency of their classification of waste streams as H. The relative ranking of the five methods (from most severe to less severe) is: Method 3>Method 1>Method 2 with extended M-factors>Method 2>Method 4. This reflects the arithmetic ranking of the concentration limits of each method when assuming M=10, and is independent of the waste streams, or the H/NH/Mirror status of the waste streams. A second approach is the absolute matching or concordance with the LoW. The LoW is taken as a reference method and the H wastes are all supposed to be HP 14. This point is discussed in the paper. The concordance for one calculation method is established by the number of wastes with identical classification by the considered calculation method and the LoW (i.e. H to H, NH to NH). The discordance is

Efficacy of a type 2 PRRSV modified live vaccine (PrimePac™ PRRS) against a Thai HP-PRRSV challenge.

PubMed

Sirisereewan, Chaitawat; Woonwong, Yonlayong; Arunorat, Jirapat; Kedkovid, Roongtham; Nedumpun, Teerawut; Kesdangsakonwut, Sawang; Suradhat, Sanipa; Thanawongnuwech, Roongroje; Teankum, Komkrich

2018-04-26

The Chinese highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) has caused a severe threat to the pig population in Southeast Asian countries. The purpose of this study was to investigate the efficacy of a type 2 PRRSV modified live vaccine (PrimePac™ PRRS, lineage 7) against a Thai HP-PRRSV (10PL01, lineage 8). Three-week-old PRRSV-free pigs were randomly assigned into three groups. Vaccinated challenged group (group 1, n = 16) was immunized with PrimePac™ PRRS vaccine at 3 weeks old. The unvaccinated challenged group (group 2, n = 16) was injected with PBS at 3 weeks old, and unvaccinated unchallenged group (group 3, n = 10) was served as a negative control. At 9 weeks old, all groups, except the negative control group, were challenged with the Thai HP-PRRSV. All pigs were monitored daily during 10 days post-infection (dpi) and were necropsied at 10 and 17 dpi. The results revealed that vaccinated challenged pigs showed significantly lower (p < 0.05) mean rectal temperatures, clinical respiratory scores, lung lesion scores, and levels of virus load in serum and lung tissue compared with the unvaccinated challenged pigs. Moreover, vaccinated challenged pigs exhibited PRRSV-specific serum neutralizing antibodies at the end of the experiment. Our findings indicated that the studied type 2 PRRSV vaccine provided partial protection against the Thai HP-PRRSV infection based on the body temperature, levels of viremia, and the severity of lung lesions. These results demonstrated that partial protection of PrimePac™ PRRS vaccine might be useful for controlling HP-PRRSV infection in the endemic area.

Test of ring, eye lens and whole body dosemeters for the dose quantity Hp(3) to be used in interventional radiology

NASA Astrophysics Data System (ADS)

Szumska, A.; Budzanowski, M.; Kopeć, R.

2017-11-01

In its statement on tissue reactions approved on 21st April 2011, the International Commission on Radiological Protection (ICRP, 2012) reviewed its recommendation concerning the equivalent dose limit for the eye lens and reduced the dose limits for occupationally exposed persons to 20 mSv in a year, averaged over defined periods of 5 years, with no single year exceeding 50 mSv. This limit was approved and written down in the new EURATOM (European Atomic Energy Community) directive 2013/59 and in the IAEA (International Atomic Energy Agency) BSS (Basic Safety Standard) of July 2014. For that reason, the necessity to monitor the eye lens may become more important than it was before. However, specially dedicated dosemeters for the dose quantity Hp(3) are using very rarely. Commonly use are only whole body personal dosemeters for the personal dose equivalent quantities Hp(10) worn on the trunk and ring dosemeters worn on finger to measure the quantity Hp(0.07). Therefore, in this work it was investigated whether dosemeters from routine use calibrated in terms of Hp(10) and Hp(0.07) and worn on thyroid collar and protective apron could deliver similar results like dedicated eye lens dosemeter worn close to the eyes. The results show that the best method if dedicated eye lens dosimeters is not used is to measure doses in terms of Hp(0.07) on the thyroid collar (Pearson product, r=0.85). Obtained results shows also importance of proper localization of eye lens dosimeter (close to the eye, from side of the X-ray source).

Polymer Exemption Guidance Manual for premanufacture notices for new chemicals under the Toxic Substances Control Act (TSCA)

EPA Pesticide Factsheets

A technical manual to accompany, but not supersede the Premanufacture Notification Exemptions; Revisions of Exemptions for Polymers; Final Rule found at 40 CFR Part 723, (60) FR 16316-16336, published Wednesday, March 29, 1995.

Load research manual. Volume 3: Load research for advanced technologies

NASA Astrophysics Data System (ADS)

1980-11-01

Technical guidelines for electric utility load research are presented. Special attention is given to issues raised by the load reporting requirements of the Public Utility Regulatory Policies Act of 1978 and to problems faced by smaller utilities that are initiating load research programs. The manual includes guides to load research literature and glossaries of load research and statistical terms. Special load research procedures are presented for solar, wind, and cogeneration technologies.

HP-65 PROGRAMMABLE POCKET CALCULATOR APPLIED TO AIR POLLUTION MEASUREMENT STUDIES: STATIONARY SOURCES

EPA Science Inventory

The handbook is intended for persons concerned with air pollution measurement studies of stationary industrial sources. It gives detailed descriptions of 22 different programs written specifically for the Hewlett Packard Model HP-65 card-programmable pocket calculator. For each p...

Automatically inserted technical details improve radiology report accuracy.

PubMed

Abujudeh, Hani H; Govindan, Siddharth; Narin, Ozden; Johnson, Jamlik Omari; Thrall, James H; Rosenthal, Daniel I

2011-09-01

To assess the effect of automatically inserted technical details on the concordance of a radiology report header with the actual procedure performed. The study was IRB approved and informed consent was waived. We obtained radiology report audit data from the hospital's compliance office from the period of January 2005 through December 2009 spanning a total of 20 financial quarters. A "discordance percentage" was defined as the percentage of total studies in which a procedure code change was made during auditing. Using Chi-square analysis we compared discordance percentages between reports with manually inserted technical details (MITD) and automatically inserted technical details (AITD). The second quarter data of 2007 was not included in the analysis as the switch from MITD to AITD occurred during this quarter. The hospital's compliance office audited 9,110 studies from 2005-2009. Excluding the 564 studies in the second quarter of 2007, we analyzed a total of 8,546 studies, 3,948 with MITD and 4,598 with AITD. The discordance percentage in the MITD group was 3.95% (156/3,948, range per quarter, 1.5- 6.1%). The AITD discordance percentage was 1.37% (63/4,598, range per quarter, 0.0-2.6%). A Chi-square analysis determined a statistically significant difference between the 2 groups (P < 0.001). There was a statistically significant improvement in the concordance of a radiology report header with the performed procedure using automatically inserted technical details compared to manually inserted details. Copyright © 2011 American College of Radiology. Published by Elsevier Inc. All rights reserved.

5. INDUSTRIAL PIPING SYSTEM FOR 500 H.P. LLEWELLYN BOILER, ADDITION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. INDUSTRIAL PIPING SYSTEM FOR 500 H.P. LLEWELLYN BOILER, ADDITION TO POWER HOUSE. United Engineering Company Ltd., Alameda Shipyard. John Hudspeth, architect, foot of Main Street, Alameda, California. Sheet M1. Plan no. 10,551. Scale 1/4 inch to the foot. June 1, 1945. pencil on vellum - United Engineering Company Shipyard, Boiler House, 2900 Main Street, Alameda, Alameda County, CA

9. Photographic copy of blueprint dated 1931; H.P. Henschien, Chicago, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photographic copy of blueprint dated 1931; H.P. Henschien, Chicago, architect; Original in collection of Rath drawings and blueprints owned by Waterloo Community Development Board, Waterloom, Iowa; PLAN OF HOG DRESSING FLOOR ON 4TH LEVEL OF BUILDING 92; SHOWS LAYOUT OF DRESSING EQUIPMENT - Rath Packing Company, Hog Dressing Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

Structure-activity relationship of HP (2-20) analog peptide: enhanced antimicrobial activity by N-terminal random coil region deletion.

PubMed

Park, Yoonkyung; Park, Seong-Cheol; Park, Hae-Kyun; Shin, Song Yub; Kim, Yangmee; Hahm, Kyung-Soo

2007-01-01

HP (2-20) (AKKVFKRLEKLFSKIQNDK) is a 19-aa antimicrobial peptide derived from N-terminus of Helicobacter pylori Ribosomal protein L1 (RpL1). In the previous study, several analogs with amino acid substitutions were designed to increase or decrease only the net hydrophobicity. In particular, substitutions of Gln(16) and Asp(18) with Trp (Anal 3) for hydrophobic amino acid caused a dramatic increase in antibiotic activity without a hemolytic effect. HP-A3 is a potent antimicrobial peptide that forms, in a hydrophobic medium, an amphipathic structure consisting of an N-terminal random coil region (residues 2-5) and extended C-terminal regular alpha-helical region (residues 6-20). To obtain the short and potent alpha-helical antimicrobial peptide, we synthesized a N-terminal random coil deleted HP-A3 (A3-NT) and examined their antimicrobial activity and mechanism of action. The resulting 15mer peptide showed increased antibacterial and antifungal activity to 2- and 4-fold, respectively, without hemolysis. Confocal fluorescence microscopy studies showed that A3-NT was accumulated in the plasma membrane. Flow cytometric analysis revealed that A3-NT acted in salt- and energy-independent manner. Furthermore, A3-NT causes significant morphological alterations of the bacterial surfaces as shown by scanning electron microscopy. Circular dichroism (CD) analysis revealed that A3-NT showed higher alpha-helical contents than the HP-A3 peptide in 50% TFE solution. Therefore, the cell-lytic efficiency of HP-A3, which depended on the alpha-helical content of peptide, correlated linearly with their antimicrobial potency.

Comparing Hp(3) evaluated from the conversion coefficients from air kerma to personal dose equivalent for eye lens dosimetry calibrated on a new cylindrical PMMA phantom

NASA Astrophysics Data System (ADS)

Esor, J.; Sudchai, W.; Monthonwattana, S.; Pungkun, V.; Intang, A.

2017-06-01

Based on a new occupational dose limit recommended by ICRP (2011), the annual dose limit for the lens of the eye for workers should be reduced from 150 mSv/y to 20 mSv/y averaged over 5 consecutive years in which no single year exceeding 50 mSv. This new dose limit directly affects radiologists and cardiologists whose work involves high radiation exposure over 20 mSv/y. Eye lens dosimetry (Hp(3)) has become increasingly important and should be evaluated directly based on dosimeters that are worn closely to the eye. Normally, Hp(3) dose algorithm was carried out by the combination of Hp(0.07) and Hp(10) values while dosimeters were calibrated on slab PMMA phantom. Recently, there were three reports from European Union that have shown the conversion coefficients from air kerma to Hp(3). These conversion coefficients carried out by ORAMED, PTB and CEA Saclay projects were performed by using a new cylindrical head phantom. In this study, various delivered doses were calculated using those three conversion coefficients while nanoDot, small OSL dosimeters, were used for Hp(3) measurement. These calibrations were performed with a standard X-ray generator at Secondary Standard Dosimetry Laboratory (SSDL). Delivered doses (Hp(3)) using those three conversion coefficients were compared with Hp(3) from nanoDot measurements. The results showed that percentage differences between delivered doses evaluated from the conversion coefficient of each project and Hp(3) doses evaluated from the nanoDots were found to be not exceeding -11.48 %, -8.85 % and -8.85 % for ORAMED, PTB and CEA Saclay project, respectively.

Coupled-Flow Simulation of HP-LP Turbines Has Resulted in Significant Fuel Savings

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

2001-01-01

Our objective was to create a high-fidelity Navier-Stokes computer simulation of the flow through the turbines of a modern high-bypass-ratio turbofan engine. The simulation would have to capture the aerodynamic interactions between closely coupled high- and low-pressure turbines. A computer simulation of the flow in the GE90 turbofan engine's high-pressure (HP) and low-pressure (LP) turbines was created at GE Aircraft Engines under contract with the NASA Glenn Research Center. The three-dimensional steady-state computer simulation was performed using Glenn's average-passage approach named APNASA. The areas upstream and downstream of each blade row mutually interact with each other during engine operation. The embedded blade row operating conditions are modeled since the average passage equations in APNASA actively include the effects of the adjacent blade rows. The turbine airfoils, platforms, and casing are actively cooled by compressor bleed air. Hot gas leaks around the tips of rotors through labyrinth seals. The flow exiting the high work HP turbines is partially transonic and, therefore, has a strong shock system in the transition region. The simulation was done using 121 processors of a Silicon Graphics Origin 2000 (NAS 02K) cluster at the NASA Ames Research Center, with a parallel efficiency of 87 percent in 15 hr. The typical average-passage analysis mesh size per blade row was 280 by 45 by 55, or approx.700,000 grid points. The total number of blade rows was 18 for a combined HP and LP turbine system including the struts in the transition duct and exit guide vane, which contain 12.6 million grid points. Design cycle turnaround time requirements ran typically from 24 to 48 hr of wall clock time. The number of iterations for convergence was 10,000 at 8.03x10(exp -5) sec/iteration/grid point (NAS O2K). Parallel processing by up to 40 processors is required to meet the design cycle time constraints. This is the first-ever flow simulation of an HP and LP

Diet manuals to practice manuals: the evolution of nutrition care.

PubMed

Chima, Cinda S

2007-02-01

Although the role of nutrition as a therapy for the sick has been recognized for centuries, the science of nutrition is a relatively young discipline. The first modern attempt to document and standardize appropriate nutrition care was the diet manual. The evolution from "diet manual" to "practice manual" is less a change in purpose than an expansion of scope. This paper reviews the history of diet manuals in the United States, focusing on the evolution of nutrition therapy and the transformation of diet manuals into practice manuals for nutrition care providers. Included is a practice-oriented summary of 7 diet manuals published by Cleveland Metropolitan General Hospital in Cleveland from 1939 to 1984, when the hospital began using nationally distributed practice manuals. These manuals exemplify changes in the practice of medicine and in the role of nutrition providers on the healthcare team. A review of the evolution of clinical decision-making as documented in diet and practice manuals reflects increasing rigor in referencing scientific evidence. Nutrition therapies that seem quaint to us now reflect the traditional origins of many medical practices that persist today. Knowledge of this history should motivate us to critically evaluate the research base that supports all aspects of nutrition therapy, develop protocols to assess practices that remain unexamined, and embrace the discipline of evidence-based practice.

Antifungal mechanism of an antimicrobial peptide, HP (2--20), derived from N-terminus of Helicobacter pylori ribosomal protein L1 against Candida albicans.

PubMed

Lee, Dong Gun; Park, Yoonkyung; Kim, Hee Nam; Kim, Hyung Keun; Kim, Pyoung Il; Choi, Bo Hwa; Hahm, Kyung-Soo

2002-03-08

The antifungal activity and mechanism of HP (2-20), a peptide derived from the N-terminus sequence of Helicobacter pylori Ribosomal Protein L1 were investigated. HP (2--20) displayed a strong antifungal activity against various fungi, and the antifungal activity was inhibited by Ca(2+) and Mg(2+) ions. In order to investigate the antifungal mechanism(s) of HP (2-20), fluorescence activated flow cytometry was performed. As determined by propidium iodide staining, Candida albicans treated with HP (2-20) showed a higher fluorescence intensity than untreated cells and was similar to melittin-treated cells. The effect on fungal cell membranes was examined by investigating the change in membrane dynamics of C. albicans using 1,6-diphenyl-1,3,5-hexatriene as a membrane probe and by testing the membrane disrupting activity using liposome (PC/PS; 3:1, w/w) and by treating protoplasts of C. albicans with the peptide. The action of peptide against fungal cell membrane was further examined by the potassium-release test, and HP (2-20) was able to increase the amount of K(+) released from the cells. The result suggests that HP (2-20) may exert its antifungal activity by disrupting the structure of cell membrane via pore formation or directly interacts with the lipid bilayers in a salt-dependent manner.

Technical Report and Data File User's Manual for the 1992 National Adult Literacy Survey.

ERIC Educational Resources Information Center

Kirsch, Irwin; Yamamoto, Kentaro; Norris, Norma; Rock, Donald; Jungeblut, Ann; O'Reilly, Patricia; Berlin, Martha; Mohadjer, Leyla; Waksberg, Joseph; Goksel, Huseyin; Burke, John; Rieger, Susan; Green, James; Klein, Merle; Campbell, Anne; Jenkins, Lynn; Kolstad, Andrew; Mosenthal, Peter; Baldi, Stephane

Chapter 1 of this report and user's manual describes design and implementation of the 1992 National Adult Literacy Survey (NALS). Chapter 2 reviews stages of sampling for national and state survey components; presents weighted and unweighted response rates for the household component; and describes non-incentive and prison sample designs. Chapter…

A Laboratory Manual for Stepwise Cerebral White Matter Fiber Dissection.

PubMed

Koutsarnakis, Christos; Liakos, Faidon; Kalyvas, Aristotelis V; Sakas, Damianos E; Stranjalis, George

2015-08-01

White matter fiber dissection is an important method in acquiring a thorough neuroanatomic knowledge for surgical practice. Previous studies have definitely improved our understanding of intrinsic brain anatomy and emphasized on the significance of this technique in modern neurosurgery. However, current literature lacks a complete and concentrated laboratory guide about the entire dissection procedure. Hence, our primary objective is to introduce a detailed laboratory manual for cerebral white matter dissection by highlighting consecutive dissection steps, and to stress important technical comments facilitating this complex procedure. Twenty adult, formalin-fixed cerebral hemispheres were included in the study. Ten specimens were dissected in the lateromedial and 10 in the mediolateral direction, respectively, using the fiber dissection technique and the microscope. Eleven and 8 consecutive and distinctive dissection steps are recommended for the lateromedial and mediolateral dissection procedures, respectively. Photographs highlighting various anatomic landmarks accompany every step. Technical recommendations, facilitating the dissection process, are also indicated. The fiber dissection technique, although complex and time consuming, offers a three-dimensional knowledge of intrinsic brain anatomy and architecture, thus improving both the quality of microneurosurgery and the patient's standard of care. The present anatomic study provides a thorough dissection manual to those who study brain anatomy using this technique. Copyright © 2015 Elsevier Inc. All rights reserved.

Bricklayer and Stonemason. U.S.O.E. 46.0102 D.O.T. 861.381, 861.781, 861.884. Student's Manual [and] Instructor's Guide.

ERIC Educational Resources Information Center

Grimes, L. A., Jr.

The student's manual in this two-part instructional kit is designed to help students in individualized courses in bricklaying and stone masonry to tie together classroom learning and on-the-job practice. The manual includes assignments, technical information, objectives that tell what the student is to learn from each assignment, and exercise…

Characterization of welded HP 9-4-30 steel for the advanced solid rocket motor

NASA Technical Reports Server (NTRS)

Watt, George William

1990-01-01

Solid rocket motor case materials must be high-strength, high-toughness, weldable alloys. The Advanced Solid Rocket Motor (ASRM) cases currently being developed will be made from a 9Ni-4Co quench and temper steel called HP 9-4-30. These ultra high-strength steels must be carefully processed to give a very clean material and a fine grained microstructure, which insures excellent ductility and toughness. The HP 9-4-30 steels are vacuum arc remelted and carbon deoxidized to give the cleanliness required. The ASRM case material will be formed into rings and then welded together to form the case segments. Welding is the desired joining technique because it results in a lower weight than other joining techniques. The mechanical and corrosion properties of the weld region material were fully studied.

Corifollitropin alfa compared to daily rFSH or HP-HMG in GnRH antagonist controlled ovarian stimulation protocol for patients undergoing assisted reproduction.

PubMed

Souza, Priscila Morais Galvão; Carvalho, Bruno Ramalho de; Nakagawa, Hitomi Miura; Rassi, Thalita Reis Esselin; Barbosa, Antônio César Paes; Silva, Adelino Amaral

2017-06-01

This study aimed to compare the outcomes of controlled ovarian stimulation (COS) with corifollitropin alfa versus daily recombinant follicle-stimulating hormone (rRFSH) or highly purified human menopausal gonadotropin (HP-HMG) in patients undergoing in vitro fertilization (IVF) cycles based on gonadotropin-releasing hormone (GnRH) antagonist protocols. The primary endpoints were total number of oocytes and mature oocytes. This retrospective study looked into 132 controlled ovarian stimulation cycles from IVF or oocyte cryopreservation performed in a private human reproduction center between January 1 and December 31, 2014. Enrollment criteria: women aged < 40 years submitted to COS with corifollitropin alfa 100µg or 150µg (n = 26) and rFSH or HP-HMG in the first seven days of treatment with daily doses of 150-225 IU (n = 106); all subjects were on GnRH antagonist protocols. The groups had similar mean ages and duration of stimulation. The mean number ± standard deviation of total aspirated oocytes and MII oocytes was 11.9±10 and 10.3±7.9 in the corifollitropin alfa group, and 10.9±7.2 and 8.6±5.7 in the group on rFSH or HMG (p>0.05). There were no significant differences in fertilization (76.9% vs. 76.8%, p=1.0), biochemical pregnancy (66.7% vs. 47.2%, p=0.1561) or embryo implantation rates (68.7% vs. 50%, p=0.2588) between the groups using corifollitropin alfa and rFSH or HMG, respectively. Corifollitropin alfa seems to be as effective as rFSH or HP-HMG when used in the first seven days of ovulation induction for patients undergoing assisted reproduction in GnRH antagonist protocols.

An efficient algorithm for building locally refined hp - adaptive H-PCFE: Application to uncertainty quantification

NASA Astrophysics Data System (ADS)

Chakraborty, Souvik; Chowdhury, Rajib

2017-12-01

Hybrid polynomial correlated function expansion (H-PCFE) is a novel metamodel formulated by coupling polynomial correlated function expansion (PCFE) and Kriging. Unlike commonly available metamodels, H-PCFE performs a bi-level approximation and hence, yields more accurate results. However, till date, it is only applicable to medium scaled problems. In order to address this apparent void, this paper presents an improved H-PCFE, referred to as locally refined hp - adaptive H-PCFE. The proposed framework computes the optimal polynomial order and important component functions of PCFE, which is an integral part of H-PCFE, by using global variance based sensitivity analysis. Optimal number of training points are selected by using distribution adaptive sequential experimental design. Additionally, the formulated model is locally refined by utilizing the prediction error, which is inherently obtained in H-PCFE. Applicability of the proposed approach has been illustrated with two academic and two industrial problems. To illustrate the superior performance of the proposed approach, results obtained have been compared with those obtained using hp - adaptive PCFE. It is observed that the proposed approach yields highly accurate results. Furthermore, as compared to hp - adaptive PCFE, significantly less number of actual function evaluations are required for obtaining results of similar accuracy.

Appendix A: The Impact of the HP 5071A on International Atomic Time

NASA Technical Reports Server (NTRS)

Allan, David W.; Lepek, Alex; Cutler, Len; Giffard, Robin; Kusters, Jack

1996-01-01

The international clock ensemble, which contributes to the generation of International Atomic Time (TAI and UTC) has improved dramatically over the last few years. The main change has been the introduction of a significant number of HP 5071A clocks. Of the 313 clocks contributing to TAI/UTC during 1994, 94 of these were HP 5071As. The environmental insensitivity of the HP 5071A clocks is more than an order of magnitude better than that of previously contributing clocks. This environmental insensitivity translates to outstanding long-term stability - with a typical flicker floor of a few x10(sup -15). in addition, there are now several hydrogen masers with cavity tuning contributing to TAI/UTC. These not only have outstanding short-term stability, but comparatively low frequency drifts and excellent intermediate-type frequency stability. By analyzing data available from the international ensemble, we have obtained two important results. First the frequency stability obtainable with an optimum algorithm is about 10(sup -15) for both the intermediate and long-term regions. It could be as good in the short-term (if time transfer measurement instabilities were reduced sufficiently. Second, with cooperation, this performance can be made available on an international basis in near real time. The recent enhancements in the contributing clocks are already providing a significant improvement in the accuracy with which UTC is made available to the world from several of the national timing centers, such as the National Institute for Standards and Technology (NIST) and the US Naval Observatory (USNO).

An HP Adaptive Discontinuous Galerkin Method for Hyperbolic Conservation Laws. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Bey, Kim S.

1994-01-01

This dissertation addresses various issues for model classes of hyperbolic conservation laws. The basic approach developed in this work employs a new family of adaptive, hp-version, finite element methods based on a special discontinuous Galerkin formulation for hyperbolic problems. The discontinuous Galerkin formulation admits high-order local approximations on domains of quite general geometry, while providing a natural framework for finite element approximations and for theoretical developments. The use of hp-versions of the finite element method makes possible exponentially convergent schemes with very high accuracies in certain cases; the use of adaptive hp-schemes allows h-refinement in regions of low regularity and p-enrichment to deliver high accuracy, while keeping problem sizes manageable and dramatically smaller than many conventional approaches. The use of discontinuous Galerkin methods is uncommon in applications, but the methods rest on a reasonable mathematical basis for low-order cases and has local approximation features that can be exploited to produce very efficient schemes, especially in a parallel, multiprocessor environment. The place of this work is to first and primarily focus on a model class of linear hyperbolic conservation laws for which concrete mathematical results, methodologies, error estimates, convergence criteria, and parallel adaptive strategies can be developed, and to then briefly explore some extensions to more general cases. Next, we provide preliminaries to the study and a review of some aspects of the theory of hyperbolic conservation laws. We also provide a review of relevant literature on this subject and on the numerical analysis of these types of problems.

CSPD Technical Manual: Procedures for Comprehensive Assessment of Educational Personnel Supply/Demand. 1990 Edition.

ERIC Educational Resources Information Center

Lauritzen, Paul; Friedman, Stephen

This manual presents procedures for collecting data to project personnel needs in the field of special education, addressing in part the Comprehensive System of Personnel Development requirements of Public Law 94-142. Implementation of the procedures identifies: areas of education that show need for additional teachers as well as areas of surplus;…

TST from geofinder traverse data on HP41CV programmable calculator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carman, G.J.

Using program subroutines designed for the HP41CV programmable calculator and the geometric data recorded from Geofinder traversing or other pace-and-compass-type methods, the true stratigraphic thickness (TST) of dipping or gently folded strata is calculated at a rate of about 30 seconds per station. TST information is therefore readily available for reviewing stratigraphic and structure data and for post survey graphical plots.

Helping Children Affected by Substance Abuse: A Manual for the Head Start Management Team.

ERIC Educational Resources Information Center

Education Development Center, Washington, DC.

The manual contains technical assistance, information, and suggested strategies for staff who work with children enrolled in Head Start who are affected by substance abuse. The information is intended to bring about change and improvement in the developmental potential of these children. Chapter 1 presents general information on children affected…

General Safety Manual for Vocational-Technical Education and Industrial Arts Programs. Bulletin No. 1674.

ERIC Educational Resources Information Center

Dennis, Bill; Poston, David

This manual is designed to offer suggestions for teaching safety in Louisiana industrial arts and vocational education programs. The suggestions and information presented are intended for use in an ongoing safety program, not a short unit presented at the beginning of the school year. Following an introduction in unit 1, the material has been…

Advanced Gas Turbine (AGT) Technology Project

NASA Technical Reports Server (NTRS)

1984-01-01

Technical work on the design and effort leading to the testing of a 74.5 kW (100 hp) automotive gas turbine engine is reviewed. Development of the engine compressor, gasifier turbine, power turbine, combustor, regenerator, and secondary system is discussed. Ceramic materials development and the application of such materials in the gas turbine engine components is described.

76 FR 57716 - Notice of Availability of a Draft Companion Manual for Executive Order 11988 Floodplain...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

... companion manual to provide agency-wide guidance for executing compliance with Executive Order 11988... procedures and guidance in accordance with specific sections of Executive Order 11988 and Executive Order.... ADDRESSES: Written comments should be sent to Emily Johannes, Senior Environmental Technical Advisor, NOAA...

ENVIRONMENTAL MONITORING AND ASSESSMENT - GREAT RIVER ECOSYSTEMS PROGRAM (EMAP-GRE) GREAT RIVER ECOSYSTEMS FIELD OPERATIONS MANUAL

EPA Science Inventory

This manual describes procedures for collecting samples and field measurements for biotic assemblages and abiotic characteristics of the Great Rivers of the Central Basin of the United States: the Missouri, Upper Mississippi, and Ohio Rivers. In addition to the technical and logi...

TECHNICAL MANUAL: A SURVEY OF EQUIPMENT AND METHODS FOR PARTICULATE SAMPLING IN INDUSTRIAL PROCESS STREAMS

EPA Science Inventory

The manual lists and describes the instruments and techniques that are available for measuring the concentration or size distribution of particles suspended in process streams. The standard, official, well established methods are described as well as some experimental methods and...

Bibliography of Technical Publications, Papers, and List of Patents, October 1985-September 1986

DTIC Science & Technology

1986-11-01

NOTICE For classified documents, follow the procedures in DoD 5200.1-R, Chapter IX or DoD 5220.22-M, " Industrial Security Manual," paragraph 19. For... Industries , Inc. Contract No. DAAK60-83-C-0040. NATICK/TR-85/064L, September 1985 (AD B107 724L). •_ CHEMCAS Volume II: User’s Manual. AMAF Industries ...the food industry . National Food Processors Association Meeting, Washington, DC, May 14, 1986. ... rib FOOD ENGINEERING DIRECTORATE Technical Papers

The exhumation of the (U)HP rocks of the Central and Western Penninic Alps: comparison study between thermo-mechanical models and field data

NASA Astrophysics Data System (ADS)

Schenker, Filippo Luca; Schmalholz, Stefan M.; Baumgartner, Lukas P.; Pleuger, Jan

2015-04-01

The Central and Western Penninic (CWP) Alps form an orogenic wedge of imbricate tectonic nappes. Orogenic wedges form typically at depths < 60 km. Nevertheless, a few nappes and massifs (i.e. Adula/Cima Lunga, Dora-Maira, Monte Rosa, Gran Paradiso, Zermatt-Saas) exhibit High- and Ultra-High-Pressure (U)HP metamorphic rocks suggesting that they were buried by subduction to depths >60 km and subsequently exhumed into the accretionary wedge. Mechanically, the exhumation of the (U)HP rocks from mantle depths can be explained by two contrasting buoyancy-driven models: (1) overall return flow of rocks in a subduction channel and (2) upward flow of individual, lighter rock units within a heavier material (Stokes flow). In this study we compare published numerical exhumation models of (1) and (2) with structural and metamorphic data of the CWP Alps. Model (1) predicts the exhumation of large volumes of (U)HP rocks within a viscous channel (1100-500 km2 in a 2D cross-section through the subduction zone). The moderate volume (e.g. ~7 km2 in a geological cross-section of the UHP unit of the Dora-Maira) and the coherent architecture of the (U)HP nappes suggests that the exhumation through (1) is unlikely for (U)HP nappes of the CWP Alps. Model (2) predicts the exhumation of appropriate volumes of (U)HP rocks, but generally the (U)HP rocks exhume vertically in the overriding plate and are not incorporated into the orogenic wedge. Nevertheless, the exhumation through (2) is feasible either with a vertical or with an extremely viscous and dense subduction channel. Whether these characteristics are applicable to the CWP UHP nappes will be discussed in light of field observations.

Rolling resistance and propulsion efficiency of manual and power-assisted wheelchairs.

PubMed

Pavlidou, Efthymia; Kloosterman, Marieke G M; Buurke, Jaap H; Rietman, Johan S; Janssen, Thomas W J

2015-11-01

Rolling resistance is one of the main forces resisting wheelchair propulsion and thus affecting stress exerted on the upper limbs. The present study investigates the differences in rolling resistance, propulsion efficiency and energy expenditure required by the user during power-assisted and manual propulsion. Different tire pressures (50%, 75%, 100%) and two different levels of motor assistance were tested. Drag force, energy expenditure and propulsion efficiency were measured in 10 able-bodied individuals under different experimental settings on a treadmill. Results showed that drag force levels were significantly higher in the 50%, compared to the 75% and 100% inflation conditions. In terms of wheelchair type, the manual wheelchair displayed significantly lower drag force values than the power-assisted one. The use of extra-power-assisted wheelchair appeared to be significantly superior to conventional power-assisted and manual wheelchairs concerning both propulsion efficiency and energy expenditure required by the user. Overall, the results of the study suggest that the use of power-assisted wheelchair was more efficient and required less energy input by the user, depending on the motor assistance provided. Copyright © 2015 IPEM. Published by Elsevier Ltd. All rights reserved.

Surface characterization of stainless HP-40 steel using laser induced μ-breakdown spectroscopy (μ -LIBS)

NASA Astrophysics Data System (ADS)

Pinto, M.; Calderón, X.; Mejía Ospino, E.; Cabanzo, R.; Poveda, Juan C.

2016-02-01

In the present study, optical microscopy in stereoscopic mode coupled to laser- induced p-breakdown spectroscopy (μ-LIBS) was applied for analysing HP-40 steel samples. microLIBS (μ-LIBS) is a new growing area that employs low energy laser pulses for the generation of plasma emission, which allow the realization of localized microanalysis [1]. This new LIBS instrument was used for the surface characterization of the steel samples in the spectral range from 356 to 401nm. Elements such as Cr, Ni, Fe, Nb, Pb, Mo, C, Mn and Si in the steel samples were investigated. The results allowed the construction of elemental distribution profiles of the samples. Complementary the HP-40 steel samples were superficially characterized by Scanning Electron Microscope (SEM).

Detailed description of the HP-9825A HFRMP trajectory processor (TRAJ)

NASA Technical Reports Server (NTRS)

Kindall, S. M.; Wilson, S. W.

1979-01-01

The computer code for the trajectory processor of the HP-9825A High Fidelity Relative Motion Program is described in detail. The processor is a 12-degrees-of-freedom trajectory integrator which can be used to generate digital and graphical data describing the relative motion of the Space Shuttle Orbiter and a free-flying cylindrical payload. Coding standards and flow charts are given and the computational logic is discussed.

Integrated Noise Model (INM) version 6.0 technical manual

DOT National Transportation Integrated Search

2002-01-31

The Federal Aviation Administration, Office of Environment and Energy (FAA, AEE-100) has : developed Version 6.0 of the Integrated Noise Model (INM) with support from the John A. Volpe : National Transportation Systems Center, Acoustics Facility (Vol...

Developing Consensus on the CompHP Professional Standards for Health Promotion in Europe

ERIC Educational Resources Information Center

Speller, Viv; Parish, Richard; Davison, Heather; Zilnyk, Anna

2012-01-01

Building on the CompHP Core Competencies for health promotion the Professional Standards for Health Promotion have been developed and consulted on across Europe. The standards were formulated to fit within the complexity of professional, occupational and educational standards frameworks in Europe as learning outcome standards with performance…

Air kerma to Hp(3) conversion coefficients for a new cylinder phantom for photon reference radiation qualities.

PubMed

Behrens, R

2012-09-01

The International Organization for Standardization (ISO) has issued a standard series on photon reference radiation qualities (ISO 4037). In this series, no conversion coefficients are contained for the quantity personal dose equivalent at a 3 mm depth, H(p)(3). In the past, for this quantity, a slab phantom was recommended as a calibration phantom; however, a cylinder phantom much better approximates the shape of a human head than a slab phantom. Therefore, in this work, the conversion coefficients from air kerma to H(p)(3) for the cylinder phantom are supplied for X- and gamma radiation qualities defined in ISO 4037.

Defense in Clausewitz’s ’On War’ and in FM (Field Manual) 100-5 and HDv 100/100.

DTIC Science & Technology

1985-06-07

preparation for the upcoming assault against Russia, Clausewitz left Prussia and joined the Russian Army to fight against the French conqueror. 13 Thus, under ...ideas. As iionic as it seems, it is reality: The next war, should it break out in Central Europe, will be fought over his grave under his principles by...detail as its predecessor. Major points--some are changes to HDv 100/1--are as follows: 1. Although one has to anticipate war under nuclear conditions

Integrated noise model (INM) version 7.0 technical manual

DOT National Transportation Integrated Search

2008-01-31

The Federal Aviation Administration, Office of Environment and Energy (FAA, AEE-100) has developed Version 7.0 of the Integrated Noise Model (INM) with support from the John A. Volpe National Transportation Systems Center, Acoustics Facility (Volpe C...

NECAP 4.1: NASA's energy-cost analysis program user's manual

NASA Technical Reports Server (NTRS)

Jensen, R. N.; Henninger, R. H.; Miner, D. L.

1983-01-01

The Enery Cost Analysis Program (NECAP) is a powerful computerized method to determine and to minimize building energy consumption. The program calculates hourly heat gain or losses taking into account the building thermal resistance and mass, using hourly weather and a "response factor' method. Internal temperatures are allowed to vary in accordance with thermostat settings and equipment capacity. A simplified input procedure and numerous other technical improvements are presented. This Users Manual describes the program and provides examples.

40 CFR 243.100 - Scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... agency including technical data and policy considerations used in arriving at this decision. In covering... AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100... Disposal Act, as amended (Pub. L. 89-272). (b) The guidelines apply to the collection of residential...

Microbial synthesis of a novel terpolyester P(LA-co-3HB-co-3HP) from low-cost substrates.

PubMed

Ren, Yilin; Meng, Dechuan; Wu, Linping; Chen, Jinchun; Wu, Qiong; Chen, Guo-Qiang

2017-03-01

Polylactide (PLA) is a bio-based plastic commonly synthesized by chemical catalytic reaction using lactic acid (LA) as a substrate. Here, novel LA-containing terpolyesters, namely, P[LA-co-3-hydroxybutyrate (3HB)-co-3-hydroxypropionate (3HP)], short as PLBP, were successfully synthesized for the first time by a recombinant Escherichia coli harbouring polyhydroxyalkanoate (PHA) synthase from Pseudomonas stutzeri (PhaC1 Ps ) with 4-point mutations at E130D, S325T, S477G and Q481K, and 3-hydroxypropionyl-CoA (3HP-CoA) synthesis pathway from glycerol, 3-hydroxybutyryl-CoA (3HB-CoA) as well as lactyl-CoA (LA-CoA) pathways from glucose. Combining these pathways with the PHA synthase mutant phaC1 Ps (E130D S325T S477G Q481K), the random terpolyester P(LA-co-3HB-co-3HP), or PLBP, was structurally confirmed by nuclear magnetic resonance to consist of 2 mol% LA, 90 mol% 3HB, and 8 mol% 3HP respectively. Remarkably, the PLBP terpolyester was produced from low-cost sustainable glycerol and glucose. Monomer ratios of PLBP could be regulated by ratios of glycerol to glucose. Other terpolyester thermal and mechanical properties can be manipulated by adjusting the monomer ratios. More PLBP applications are to be expected. © 2016 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

Dissociated effects of distractors on saccades and manual aiming.

PubMed

McIntosh, Robert D; Buonocore, Antimo

2012-08-01

The remote distractor effect (RDE) is a robust phenomenon whereby target-directed saccades are delayed by the appearance of a distractor. This effect persists even when the target location is perfectly predictable. The RDE has been studied extensively in the oculomotor domain but it is unknown whether it generalises to other spatially oriented responses. In three experiments, we tested whether the RDE generalises to manual aiming. Experiment 1 required participants to move their hand or eyes to predictable targets presented alone or accompanied by a distractor in the opposite hemifield. The RDE was observed for the eyes but not for the hand. Experiment 2 replicated this dissociation in a more naturalistic task in which eye movements were not constrained during manual aiming. Experiment 3 confirmed the lack of manual RDE across a wider range of distractor delays (0, 50, 100, and 150 ms). Our data imply that the RDE is specific to the oculomotor system, at least for non-foveal distractors. We suggest that the oculomotor RDE reflects competitive interactions between target and distractor representations in the superior colliculus, which are not necessarily shared by manual aiming.

45. 800 H.P. WATER WHEEL UNIT (LEFT HAND) DIRECT CONNECTED ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. 800 H.P. WATER WHEEL UNIT (LEFT HAND) DIRECT CONNECTED TO A 500 K.W. G.E. CO. GENERATOR, SPEED 176 R.P.M., HEAD OF WATER 305 FT EFF., FOR SANTA ANA RIVER NO. 2 PLANT. ABNER DOBLE CO., ENGINEERS, SAN FRANCISCO, AUG. 29, 1904. TRACED FROM DOBLE BLUE PRINT, SEPT. 9, 1911. SCE drawing no. 5698. - Santa Ana River Hydroelectric System, SAR-2 Powerhouse, Redlands, San Bernardino County, CA

An Overview of Addiction Research Center Inventory Scales (ARCI): An Appendix and Manual of Scales.

ERIC Educational Resources Information Center

Haertzen, C.A.

The Addiction Research Center Inventory is a 550 item multipurpose test measuring the broad range of physical, emotive, cognitive, and subjective effects of drugs. This manual provides technical information concerning 38 most valid scales, a quantitative method for characterizing the similarity of a profile of scores for the subject, group, or…

Convergence of an hp-Adaptive Finite Element Strategy in Two and Three Space-Dimensions

NASA Astrophysics Data System (ADS)

Bürg, Markus; Dörfler, Willy

2010-09-01

We show convergence of an automatic hp-adaptive refinement strategy for the finite element method on the elliptic boundary value problem. The strategy is a generalization of a refinement strategy proposed for one-dimensional situations to problems in two and three space-dimensions.

Technical publication transfer test with McDonnell Aircraft Company: MIL-M-28001 (SGML) and MIL-D-28000 Class 1 (IGES)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-06-25

The CALS Test Network (CTN) conducted a CTN Planned Test (CPT) of several CALS standards related to the transfer of technical publication data: MIL-STD-1840A (1840A), MIL-D-28000 Class I (28000), MIL-M-28001 (28001), and MIL-D-28003 (28003). The test was conducted with the McDonnell Aircraft Company (CMAIR) of St. Louis, Missouri in accordance with part one of CTN Test Plan CTN89-TM-06 and using material from an F-15E technical manual. One focus of the test was the transfer of a moderately large volume of technical publication data. There were 9 text files, 74 Initial Graphics Exchange Specification (IGES) files, and 74 Computer Graphics Metafilemore » (CGM) files in the exchange package. A noteworthy feature of the test was its early attempt to exchange CGM data. Part one of CTN89-TM-06 called for technical publication data to be output from MCAIR's Xyvision system on 9-track magnetic tape. The data was to be in accordance with the 28001 subset of the Standard Generalized Mark-up Language (SGML) and the 28001 Document Type Definition (DTD) that conformed to MIL-M-38784B, the general style and format requirements for technical manuals. Technical illustrations in the manual were to be done in accordance with 28000 Class I (IGES) and 28003 (CGM). Part two of the test called for the test tape to be read into another technical publication system where the text would be modified and the vector illustrations would all be converted to raster, in accordance with MIL-R-28002. This part of the test is not covered in this report.« less

Evidence for a Mid-Crustal Continental Suture and Implications for Multistage (U)HP exhumation, Liverpool Land, East Greenland

NASA Astrophysics Data System (ADS)

Johnston, S.; Brueckner, H.; Gehrels, G.; Manthei, C.; Hacker, B.; Kylander-Clark, A.; Hartz, E. H.

2008-12-01

The East Greenland Caledonides consists of a series of west-directed sheets that formed from 460-360 Ma as Baltica subducted westward beneath Laurentia, and offer an opportunity to study high- and ultrahigh- pressure exhumation in orogenic hangingwalls. The Liverpool Land (LL) gneiss complex, 100 km east of the nearest Caledonian gneisses, provides a window into the deepest levels of the Greenland Caledonides. From the bottom up, the LL tectonostratigraphy is comprised of the eclogite-bearing Tvaerdal orthogneiss and the granulite-facies Jaettedal paragneiss structurally below the top-N Hurry Inlet Detachment. We present new thermobarometry and U/Pb zircon and titanite geochronology from the LL gneisses to define the tectonostratigraphy, continental affinity, and exhumation histories of the LL gneiss complex. The Tvaerdal orthogneiss consists of felsic orthogneisses that host rare ultramafic bodies (Fo92) and mafic boudins that yield peak pressures of >25 kbar at 800°C. Host gneiss zircons dated using LA-MC- ICPMS yield 1676 ± 17 Ma (2s) cores with 403 ± 6 Ma (2s) rims that suggest Mesoproterozoic emplacement of the original intrusive body followed by late-Caledonian deformation. The Tvaerdal orthogneiss also includes voluminous decompression melts; one yielded a TIMS U/Pb titanite age of 387.5 ± 2.2 Ma (2s). The structurally higher Jaettedal paragneiss consists of pelitic gneisses interlayered with granodioritic-dioritic orthogneisses. The Jaettedal-Tvaerdal contact is petrologically abrupt and concordant to regional foliation and lacks sub-amphibolite-facies displacement. Aluminum silicate-bearing pelitic assemblages within the Jaettedal paragneiss yield peak metamorphic conditions of 10-11 kbar at 750- 800°C. U/Pb age maps made using LA-MC-ICPMS from three paragneisses reveal Mesoproterozoic- Archean detrital cores with Caledonian rim overgrowths that cluster between 439-434 Ma. An amphibolite restite from the Jaettedal paragneiss yielded a TIMS U

Helicobacter pylori protein HP0986 (TieA) interacts with mouse TNFR1 and triggers proinflammatory and proapoptotic signaling pathways in cultured macrophage cells (RAW 264.7).

PubMed

Ansari, Suhail A; Devi, Savita; Tenguria, Shivendra; Kumar, Ashutosh; Ahmed, Niyaz

2014-08-01

HP0986 protein of Helicobacter pylori has been shown to trigger induction of proinflammatory cytokines (IL-8 and TNF-α) through the activation of NF-κB and also to induce Fas mediated apoptosis of human macrophage cells (THP-1). In this study, we unravel mechanistic details of the biological effects of this protein in a murine macrophage environment. Up regulation of MCP-1 and TNF-α in HP0986-induced RAW 264.7 cells occurred subsequent to the activation and translocation of NF-κB to the cell nucleus. Further, HP0986 induced apoptosis of RAW 264.7 cells through Fas activation and this was in agreement with previous observations made with THP-1 cells. Our studies indicated activation of TNFR1 through interaction with HP0986 and this elicited the aforementioned responses independent of TLR2, TLR4 or TNFR2. We found that mouse TNFR1 activation by HP0986 facilitates formation of a complex comprising of TNFR1, TRADD and TRAF2, and this occurs upstream of NF-κB activation. Furthermore, FADD also forms a second complex, at a later stage, together with TNFR1 and TRADD, resulting in caspase-8 activation and thereby the apoptosis of RAW 264.7 cells. In summary, our observations reveal finer details of the functional activity of HP0986 protein in relation to its behavior in a murine macrophage cell environment. These findings reconfirm the proinflammatory and apoptotic role of HP0986 signifying it to be an important trigger of innate responses. These observations form much needed baseline data entailing future in vivo studies of the functions of HP0986 in a murine model. Copyright © 2014 Elsevier Ltd. All rights reserved.

Research in Automatic Russian-English Scientific and Technical Lexicography. Final Report.

ERIC Educational Resources Information Center

Wayne State Univ., Detroit, MI.

Techniques of reversing English-Russian scientific and technical dictionaries into Russian-English versions through semi-automated compilation are described. Sections on manual and automatic processing discuss pre- and post-editing, the task program, updater (correction of errors and revision by specialist in a given field), the system employed…

Cooperative Education Guidelines for Technical Colleges and Other Associate Degree Programs.

ERIC Educational Resources Information Center

Streb, Thomas C.; Hammen, William C.

Guidelines for cooperative education in two-year technical colleges as well as for other associate degree programs are presented in this 15 chapter manual. Chapter 1 covers cooperative education history, current status, advantages and disadvantages, purposes, and information sources. Chapter 2 on personnel presents an overview and discusses the…

Critical Success Factors in Crafting Strategic Architecture for E-Learning at HP University

ERIC Educational Resources Information Center

Sharma, Kunal; Pandit, Pallvi; Pandit, Parul

2011-01-01

Purpose: The purpose of this paper is to outline the critical success factors for crafting a strategic architecture for e-learning at HP University. Design/methodology/approach: A descriptive survey type of research design was used. An empirical study was conducted on students enrolled with the International Centre for Distance and Open Learning…

Variational Trajectory Optimization Tool Set: Technical description and user's manual

NASA Technical Reports Server (NTRS)

Bless, Robert R.; Queen, Eric M.; Cavanaugh, Michael D.; Wetzel, Todd A.; Moerder, Daniel D.

1993-01-01

The algorithms that comprise the Variational Trajectory Optimization Tool Set (VTOTS) package are briefly described. The VTOTS is a software package for solving nonlinear constrained optimal control problems from a wide range of engineering and scientific disciplines. The VTOTS package was specifically designed to minimize the amount of user programming; in fact, for problems that may be expressed in terms of analytical functions, the user needs only to define the problem in terms of symbolic variables. This version of the VTOTS does not support tabular data; thus, problems must be expressed in terms of analytical functions. The VTOTS package consists of two methods for solving nonlinear optimal control problems: a time-domain finite-element algorithm and a multiple shooting algorithm. These two algorithms, under the VTOTS package, may be run independently or jointly. The finite-element algorithm generates approximate solutions, whereas the shooting algorithm provides a more accurate solution to the optimization problem. A user's manual, some examples with results, and a brief description of the individual subroutines are included.

Recent advances with quiescent power supply current (I(sub DDQ)) testing at Sandia using the HP82000

NASA Astrophysics Data System (ADS)

Righter, A. W.; Leong, D. J.; Cox, L. B.

Last year at the HP82000 Users Group Meeting, Sandia National Laboratories gave a presentation on I(sub DDQ) testing. This year, some advances are presented on this testing including DUT board fixturing, external DC PMU measurement, and automatic IDD-All circuit calibration. Implementation is examined more than theory, with results presented from Sandia tests. After a brief summary I(sub DDQ) theory and testing concepts, how the break (hold state) vector and data formatting present a test vector generation concern for the HP82000 is described. Fixturing of the DUT board for both types of I(sub DDQ) measurement is then discussed, along with how the continuity test and test vector generation must be taken into account. Results of a test including continuity, IDD-All and I(sub DDQ) Value measurements is shown. Next, measurement of low current using an external PMU is discussed, including noise considerations, implementation and some test results showing nA-range measurements. A method is presented for automatic calibration of the IDD-All analog comparator circuit using RM BASIC on the HP82000, with implementation and measurement results. Finally, future directions for research in this area is explored.

2002 Construction manual

DOT National Transportation Integrated Search

2002-01-01

The Illinois Department of Transportation's Highway Construction Manual has been updated from its previous version. All previous editions of this manual are now obsolete and changes in content have been marked. The Construction Manual provides inform...

Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway.

PubMed

Garfinkel, Benjamin P; Arad, Shiri; Le, Phuong T; Bustin, Michael; Rosen, Clifford J; Gabet, Yankel; Orly, Joseph

2015-12-01

Heterochromatin protein 1 binding protein 3 (HP1BP3) is a recently described histone H1-related protein with roles in chromatin structure and transcriptional regulation. To explore the potential physiological role of HP1BP3, we have previously described an Hp1bp3(-/-) mouse model with reduced postnatal viability and growth. We now find that these mice are proportionate dwarfs, with reduction in body weight, body length, and organ weight. In addition to their small size, microcomputed tomography analysis showed that Hp1bp3(-/-) mice present a dramatic impairment of their bone development and structure. By 3 weeks of age, mice of both sexes have severely impaired cortical and trabecular bone, and these defects persist into adulthood and beyond. Primary cultures of both osteoblasts and osteoclasts from Hp1bp3(-/-) bone marrow and splenocytes, respectively, showed normal differentiation and function, strongly suggesting that the impaired bone accrual is due to noncell autonomous systemic cues in vivo. One major endocrine pathway regulating both body growth and bone acquisition is the IGF regulatory system, composed of IGF-1, the IGF receptors, and the IGF-binding proteins (IGFBPs). At 3 weeks of age, Hp1bp3(-/-) mice exhibited a 60% reduction in circulating IGF-1 and a 4-fold increase in the levels of IGFBP-1 and IGFBP-2. These alterations were reflected in similar changes in the hepatic transcripts of the Igf1, Igfbp1, and Igfbp2 genes. Collectively, these results suggest that HP1BP3 plays a key role in normal growth and bone development by regulating transcription of endocrine IGF-1 components.

Caltrans : construction manual

DOT National Transportation Integrated Search

2009-08-01

Caltrans intends this manual as a resource for all personnel engaged in contract administration. The manual establishes policies and procedures for the construction phase of Caltrans projects. However, this manual is not a contract document. It impos...

Techniques for predicting high-risk drivers for alcohol countermeasures. Volume 1, Technical report

DOT National Transportation Integrated Search

1979-05-01

This technical report, a companion to the Volume II User Manual by the same name describes the development and testing of predictive models for identifying individual with a high risk of alcohol/related (A/R) crash involvement. From a literature revi...

Technical Findings, Lessons Learned, and Recommendations Resulting from the Helios Prototype Vehicle Mishap

NASA Technical Reports Server (NTRS)

Noll, Thomas E.; Ishmael, Stephen D.; Henwood, Bart; Perez-Davis, Marla E.; Tiffany, Geary C.; Madura, John; Gaier, Matthew; Brown, John M.; Wierzbanowski, Ted

2007-01-01

The Helios Prototype was originally planned to be two separate vehicles, but because of resource limitations only one vehicle was developed to demonstrate two missions. The vehicle consisted of two configurations, one for each mission. One configuration, designated HP01, was designed to operate at extremely high altitudes using batteries and high-efficiency solar cells spread across the upper surface of its 247-foot wingspan. On August 13, 2001, the HP01 configuration reached an altitude of 96,863 feet, a world record for sustained horizontal flight by a winged aircraft. The other configuration, designated HP03, was designed for long-duration flight. The plan was to use the solar cells to power the vehicle's electric motors and subsystems during the day and to use a modified commercial hydrogen-air fuel cell system for use during the night. The aircraft design used wing dihedral, engine power, elevator control surfaces, and a stability augmentation and control system to provide aerodynamic stability and control. At about 30 minutes into the second flight of HP03, the aircraft encountered a disturbance in the way of turbulence and morphed into an unexpected, persistent, high dihedral configuration. As a result of the persistent high dihedral, the aircraft became unstable in a very divergent pitch mode in which the airspeed excursions from the nominal flight speed about doubled every cycle of the oscillation. The aircraft s design airspeed was subsequently exceeded and the resulting high dynamic pressures caused the wing leading edge secondary structure on the outer wing panels to fail and the solar cells and skin on the upper surface of the wing to rip away. As a result, the vehicle lost its ability to maintain lift, fell into the Pacific Ocean within the confines of the U.S. Navy's Pacific Missile Range Facility, and was destroyed. This paper describes the mishap and its causes, and presents the technical recommendations and lessons learned for improving the design

Stray Light Analyis With The HP-41C/CV Calculator

NASA Astrophysics Data System (ADS)

Bamberg, Jack A.

1983-10-01

A stray radiation analysis program (nicknamed MINI-APART after its namesake: APART) suitable for use on the HP-41C/CV calculator is described. The program is ideally suited for quick estimates of stray light performance in well-baffled optical systems, which are limited by scatter from the first optical element. Critical path models are described, including single scatter, double scatter, diffraction-scatter, and thermal emission-scatter. Program use is illustrated, and several comparisons are made with the results obtained by the large stray radiation programs, GUERAP-3 and APART/PADE.

Word Lists to Simplify Vocabulary of Technical Information. Final Report.

ERIC Educational Resources Information Center

Kincaid, J. Peter; And Others

This report describes eight word lists developed for use as part of the computer readability editing system (CRES), which was developed to serve as an author's aid in improving the ease of comprehending Navy technical manuals and training materials. The system has features which flag uncommon and misspelled words and long sentences, suggest simple…

Groundwater technical procedures of the U.S. Geological Survey

USGS Publications Warehouse

Cunningham, William L.; Schalk, Charles W.

2011-01-01

A series of groundwater technical procedures documents (GWPDs) has been released by the U.S. Geological Survey, Water-Resources Discipline, for general use by the public. These technical procedures were written in response to the need for standardized technical procedures of many aspects of groundwater science, including site and measuring-point establishment, measurement of water levels, and measurement of well discharge. The techniques are described in the GWPDs in concise language and are accompanied by necessary figures and tables derived from cited manuals, reports, and other documents. Because a goal of this series of procedures is to remain current with the state of the science, and because procedures change over time, this report is released in an online format only. As new procedures are developed and released, they will be linked to this document.

Ariel: a UAV designed to fly at 100,000 ft

NASA Astrophysics Data System (ADS)

Papadales, Basil S.; Schoenung, Susan M.

1996-11-01

The Ariel unmanned aerial vehicle (UAV) was designed for NASA Ames Research Center to satisfy emerging civil science needs for subsonic flight at altitudes on the order of 100,000 ft. These include atmospheric monitoring of chemical species and environmental conditions related to global climate change. Ariel may be useful for a variety of civil and military remote sensing applications since, at an altitude of 100,000 ft, the UAV wold fly above all manned aircraft. The Ariel has a gross weight of 6400 lb with a wing span of 105 ft, a little shorter than that of the manned ER-2. Ariel is powered by a new propulsion system called the Bipropellant Expansion Turbine (BET). With a 300 hp BET, Ariel can climb to an altitude of 100,000 ft and loiter at Mach 0.63 for two hours while carrying a 600 lb payload. During this loiter, the UAV travels about 750 nm at 100,000 ft. It is possible to trade payload weight for range or endurance. Further design optimization or use of more advanced technology can result in substantially improved performance. With adequate funding, a proof of concept version of Ariel could be developed for initial flights by the year 2000.

Pattern Recognition of Adsorbing HP Lattice Proteins

NASA Astrophysics Data System (ADS)

Wilson, Matthew S.; Shi, Guangjie; Wüst, Thomas; Landau, David P.; Schmid, Friederike

2015-03-01

Protein adsorption is relevant in fields ranging from medicine to industry, and the qualitative behavior exhibited by course-grained models could shed insight for further research in such fields. Our study on the selective adsorption of lattice proteins utilizes the Wang-Landau algorithm to simulate the Hydrophobic-Polar (H-P) model with an efficient set of Monte Carlo moves. Each substrate is modeled as a square pattern of 9 lattice sites which attract either H or P monomers, and are located on an otherwise neutral surface. The fully enumerated set of 102 unique surfaces is simulated with each protein sequence. A collection of 27-monomer sequences is used- each of which is non-degenerate and protein-like. Thermodynamic quantities such as the specific heat and free energy are calculated from the density of states, and are used to investigate the adsorption of lattice proteins on patterned substrates. Research supported by NSF.

10. BOILER #16 (BUILDING L8) TO LEFT, L.P. AND H.P. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. BOILER #16 (BUILDING L8) TO LEFT, L.P. AND H.P. BOILER ROOMS (BUILDINGS L4 AND L2) TO RIGHT, AND STEPHENS SUBSTATION (BUILDING L6) IN BACKGROUND, FROM THE ROOF OF THE POWERHOUSE EXTENSION (BUILDING L5) - Portland General Electric Company, Station "L", 1841 Southeast Water Street, Portland, Multnomah County, OR

Laplace and Z Transform Solutions of Differential and Difference Equations With the HP-41C.

ERIC Educational Resources Information Center

Harden, Richard C.; Simons, Fred O., Jr.

1983-01-01

A previously developed program for the HP-41C programmable calculator is extended to handle models of differential and difference equations with multiple eigenvalues. How to obtain difference equation solutions via the Z transform is described. (MNS)

Kansas highway LED illumination manual : a guide for the use of LED lighting systems : [technical summary].

DOT National Transportation Integrated Search

2015-12-01

The research project was aimed to assist the Kansas Department of Transportation (KDOT) in the development of a Highway LED Illumination Manual for guiding the upcoming implementation of successful LED roadway lighting systems in Kansas to replace th...

Load research manual. Volume 2. Fundamentals of implementing load research procedures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandenburg, L.; Clarkson, G.; Grund, Jr., C.

This three-volume manual presents technical guidelines for electric utility load research. Special attention is given to issues raised by the load data reporting requirements of the Public Utility Regulatory Policies Act of 1978 and to problems faced by smaller utilities that are initiating load research programs. In Volumes 1 and 2, procedures are suggested for determining data requirements for load research, establishing the size and customer composition of a load survey sample, selecting and using equipment to record customer electricity usage, processing data tapes from the recording equipment, and analyzing the data. Statistical techniques used in customer sampling are discussedmore » in detail. The costs of load research also are estimated, and ongoing load research programs at three utilities are described. The manual includes guides to load research literature and glossaries of load research and statistical terms.« less

Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway

PubMed Central

Arad, Shiri; Le, Phuong T.; Bustin, Michael; Rosen, Clifford J.; Gabet, Yankel

2015-01-01

Heterochromatin protein 1 binding protein 3 (HP1BP3) is a recently described histone H1-related protein with roles in chromatin structure and transcriptional regulation. To explore the potential physiological role of HP1BP3, we have previously described an Hp1bp3−/− mouse model with reduced postnatal viability and growth. We now find that these mice are proportionate dwarfs, with reduction in body weight, body length, and organ weight. In addition to their small size, microcomputed tomography analysis showed that Hp1bp3−/− mice present a dramatic impairment of their bone development and structure. By 3 weeks of age, mice of both sexes have severely impaired cortical and trabecular bone, and these defects persist into adulthood and beyond. Primary cultures of both osteoblasts and osteoclasts from Hp1bp3−/− bone marrow and splenocytes, respectively, showed normal differentiation and function, strongly suggesting that the impaired bone accrual is due to noncell autonomous systemic cues in vivo. One major endocrine pathway regulating both body growth and bone acquisition is the IGF regulatory system, composed of IGF-1, the IGF receptors, and the IGF-binding proteins (IGFBPs). At 3 weeks of age, Hp1bp3−/− mice exhibited a 60% reduction in circulating IGF-1 and a 4-fold increase in the levels of IGFBP-1 and IGFBP-2. These alterations were reflected in similar changes in the hepatic transcripts of the Igf1, Igfbp1, and Igfbp2 genes. Collectively, these results suggest that HP1BP3 plays a key role in normal growth and bone development by regulating transcription of endocrine IGF-1 components. PMID:26402843

Endpoint Accuracy in Manual Control of a Steerable Needle.

PubMed

van de Berg, Nick J; Dankelman, Jenny; van den Dobbelsteen, John J

2017-02-01

To study the ability of a human operator to manually correct for errors in the needle insertion path without partial withdrawal of the needle by means of an active, tip-articulated steerable needle. The needle is composed of a 1.32-mm outer-diameter cannula, with a flexure joint near the tip, and a retractable stylet. The bending stiffness of the needle resembles that of a 20-gauge hypodermic needle. The needle functionality was evaluated in manual insertions by steering to predefined targets and a lateral displacement of 20 mm from the straight insertion line. Steering tasks were conducted in 5 directions and 2 tissue simulants under image guidance from a camera. The repeatability in instrument actuations was assessed during 100 mm deep automated insertions with a linear motor. In addition to tip position, tip angles were tracked during the insertions. The targeting error (mean absolute error ± standard deviation) during manual steering to 5 different targets in stiff tissue was 0.5 mm ± 1.1. This variability in manual tip placement (1.1 mm) was less than the variability among automated insertions (1.4 mm) in the same tissue type. An increased tissue stiffness resulted in an increased lateral tip displacement. The tip angle was directly controlled by the user interface, and remained unaffected by the tissue stiffness. This study demonstrates the ability to manually steer needles to predefined target locations under image guidance. Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.

CSTEM User Manual

NASA Technical Reports Server (NTRS)

Hartle, M.; McKnight, R. L.

2000-01-01

This manual is a combination of a user manual, theory manual, and programmer manual. The reader is assumed to have some previous exposure to the finite element method. This manual is written with the idea that the CSTEM (Coupled Structural Thermal Electromagnetic-Computer Code) user needs to have a basic understanding of what the code is actually doing in order to properly use the code. For that reason, the underlying theory and methods used in the code are described to a basic level of detail. The manual gives an overview of the CSTEM code: how the code came into existence, a basic description of what the code does, and the order in which it happens (a flowchart). Appendices provide a listing and very brief description of every file used by the CSTEM code, including the type of file it is, what routine regularly accesses the file, and what routine opens the file, as well as special features included in CSTEM.

Instruct coders' manual

NASA Technical Reports Server (NTRS)

Friend, J.

1971-01-01

A manual designed both as an instructional manual for beginning coders and as a reference manual for the coding language INSTRUCT, is presented. The manual includes the major programs necessary to implement the teaching system and lists the limitation of current implementation. A detailed description is given of how to code a lesson, what buttons to push, and what utility programs to use. Suggestions for debugging coded lessons and the error messages that may be received during assembly or while running the lesson are given.

Policies and Procedures Governing the Operation of Vocational-Technical Education in Nevada.

ERIC Educational Resources Information Center

Nevada State Dept. of Education, Carson City. Div. of Vocational-Technical and Adult Education.

This manual was prepared to assist local public schools in organizing and conducting a broadened program of vocational education of significant scope. Operating policies and procedures are provided in areas of: (1) Administration of Vocational-Technical Education, (2) Agricultural Education, (3) Vocational Business and Office Occupations, (4)…

Manual therapy and exercise for rotator cuff disease.

PubMed

Page, Matthew J; Green, Sally; McBain, Brodwen; Surace, Stephen J; Deitch, Jessica; Lyttle, Nicolette; Mrocki, Marshall A; Buchbinder, Rachelle

2016-06-10

43 trials. We were unable to perform any meta-analyses because of clinical heterogeneity or incomplete outcome reporting. One trial compared manual therapy and exercise with placebo (inactive ultrasound therapy) in 120 participants with chronic rotator cuff disease (high quality evidence). At 22 weeks, the mean change in overall pain with placebo was 17.3 points on a 100-point scale, and 24.8 points with manual therapy and exercise (adjusted mean difference (MD) 6.8 points, 95% confidence interval (CI) -0.70 to 14.30 points; absolute risk difference 7%, 1% fewer to 14% more). Mean change in function with placebo was 15.6 points on a 100-point scale, and 22.4 points with manual therapy and exercise (adjusted MD 7.1 points, 95% CI 0.30 to 13.90 points; absolute risk difference 7%, 1% to 14% more). Fifty-seven per cent (31/54) of participants reported treatment success with manual therapy and exercise compared with 41% (24/58) of participants receiving placebo (risk ratio (RR) 1.39, 95% CI 0.94 to 2.03; absolute risk difference 16% (2% fewer to 34% more). Thirty-one per cent (17/55) of participants reported adverse events with manual therapy and exercise compared with 8% (5/61) of participants receiving placebo (RR 3.77, 95% CI 1.49 to 9.54; absolute risk difference 23% (9% to 37% more). However adverse events were mild (short-term pain following treatment).Five trials (low quality evidence) found no important differences between manual therapy and exercise compared with glucocorticoid injection with respect to overall pain, function, active shoulder abduction and quality of life from four weeks up to 12 months. However, global treatment success was more common up to 11 weeks in people receiving glucocorticoid injection (low quality evidence). One trial (low quality evidence) showed no important differences between manual therapy and exercise and arthroscopic subacromial decompression with respect to overall pain, function, active range of motion and strength at six and

Relationship between longevity and lifeline: a manual study of 100 patients.

PubMed Central

Newrick, P G; Affie, E; Corrall, R J

1990-01-01

The relationship between length of lifeline and age at death has been evaluated in 100 consecutive autopsies. A highly significant association between the two was discovered which was strengthened further when hand size was controlled for. We feel that a powerful new prognostic sign may thus be within grasp. Images Figure 1. PMID:2231578

The Mt. Ochi melange (South Evvia Island, Greece): a case study for HP metamorphism and syn-convergent exhumation.

NASA Astrophysics Data System (ADS)

Moustaka, Eleni; Soukis, Konstantinos; Huet, Benjamin; Lozios, Stylianos; Magganas, Andreas

2014-05-01

The Attic-Cycladic complex (central Aegean Sea, Greece) experienced profound extension since at least the Oligo-Miocene boundary during which the previously thickened crust was reworked by a series of detachments forming the NE directed North Cycladic Detachment System (NCDS) and the SSW directed West Cycladic Detachment System (WCDS). South Evvia Island is located at the northwestern part of the Attic Cycladic complex linking the highly thinned and polymetamorphosed central part of the complex with mainland Greece. Furthermore, greenschists-facies retrograde metamorphism has only partially overprinted the HP mineral assemblages. Consequently, it is an ideal area to study tectonic processes associated with subduction, HP metamorphism and subsequent exhumation from eclogitic depths to the surface. Geological mapping in 1:2:000 scale revealed that the tectonostratigraphy of Mt. Ochi includes three distinct units all metamorphosed in HP conditions followed by greenschist facies overprint. These units are from top to bottom a) the Ochi Unit, a thick metavolcanosedimentary sequence with some intensely folded cipoline marble intercalations and isolated occurrences of metabasic rocks b) the ophiolitic mélange (metagabbros, metawherlites, peridotites, metabasites within a metasedimentary+serpentinite matrix) and c) the lowermost Styra Unit, a cipoline marble-dominated unit with thin mica schists and rare quartzitic layers often boudinaged. The thrust fault that was responsible for the juxtaposition of these three units acted in an early stage during HP metamorphism and it was isoclinally folded and sheared by the following syn-metamorphic deformation events. Detailed structural study in meso- and microscopic scale combined with petrological and geochemical analyses of the Mt Ochi rocks led to the distinction of at least three syn-metamorphic and two post-metamorphic deformation episodes that affected all units. The oldest structure identified is a relic foliation formed

78 FR 23556 - Supplemental Notice of Technical Conference

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

...] Supplemental Notice of Technical Conference Docket Nos. Filing via the Internet RM07-16-000 Electronic Tariff... hold a technical conference on April 16, 2013 from 10:00 a.m. to 1:00 p.m. (EST) to demonstrate changes... there have been changes affecting the off-site broadcast of the technical conference. \\1\\ Notice of...

Assessing the economics of processing end-of-life vehicles through manual dismantling.

PubMed

Tian, Jin; Chen, Ming

2016-10-01

Most dismantling enterprises in a number of developing countries, such as China, usually adopt the "manual+mechanical" dismantling approach to process end-of-life vehicles. However, the automobile industry does not have a clear indicator to reasonably and effectively determine the manual dismantling degree for end-of-life vehicles. In this study, five different dismantling scenarios and an economic system for end-of-life vehicles were developed based on the actual situation of end-of-life vehicles. The fuzzy analytic hierarchy process was applied to set the weights of direct costs, indirect costs, and sales and to obtain an optimal manual dismantling scenario. Results showed that although the traditional method of "dismantling to the end" can guarantee the highest recycling rate, this method is not the best among all the scenarios. The profit gained in the optimal scenario is 100.6% higher than that in the traditional scenario. The optimal manual dismantling scenario showed that enterprises are required to select suitable parts to process through manual dismantling. Selecting suitable parts maximizes economic profit and improves dismantling speed. Copyright © 2016 Elsevier Ltd. All rights reserved.

pHP-Tethered N-Acyl Carbamate: A Photocage for Nicotinamide.

PubMed

Salahi, Farbod; Purohit, Vatsal; Ferraudi, Guillermo; Stauffacher, Cynthia; Wiest, Olaf; Helquist, Paul

2018-05-04

The synthesis of a new photocaged nicotinamide having an N-acyl carbamate linker and a p-hydroxyphenacyl (pHP) chromophore is described. The photophysical and photochemical studies showed an absorption maximum at λ = 330 nm and a quantum yield for release of 11% that are dependent upon both pH and solvent. While the acyl carbamate releases nicotinamide efficiently, a simpler amide linker was inert to photocleavage. This photocaged nicotinamide has significant advantages with respect to quantum yield, absorbance wavelength, rate of release, and solubility that make it the first practical example of a photocaged amide.

Technical skills requirement of Indonesian construction labors to work in Malaysia

NASA Astrophysics Data System (ADS)

Adi, Henny Pratiwi

2017-03-01

Labors skills is an important part of construction projects implementation. Suitability between the skills possessed by labors with the skills needed by user is required to increase employment opportunities. Malaysia is a country that using construction labors from Indonesia. This study aims to get the kind of technical skills required by users of Indonesian constructian labors in Malaysia and also the importance level of technical skills. Data collecting in this research was conducted through interviews and questionnaires on contractors in Malaysia. The next stage was determine the importance level of technical skills in work field of carpenter, bricklayer, plumber and painters. The importance level of technical skills analyzed using the Relative Importance Index (RII). The results showed that mastering the operation of both instruments either manually or electrically is the most importance in the technical skills. Therefore, an understanding of the types of equipment for work field and the manner of operation is need to had by Indonesian construction labors who will work in Malaysia.

Training Manual for Elements of Interface Definition and Control

NASA Technical Reports Server (NTRS)

Lalli, Vincent R. (Editor); Kastner, Robert E. (Editor); Hartt, Henry N. (Editor)

1997-01-01

The primary thrust of this manual is to ensure that the format and information needed to control interfaces between equipment are clear and understandable. The emphasis is on controlling the engineering design of the interface and not on the functional performance requirements of the system or the internal workings of the interfacing equipment. Interface control should take place, with rare exception, at the interfacing elements and no further. There are two essential sections of the manual. Chapter 2, Principles of Interface Control, discusses how interfaces are defined. It describes different types of interfaces to be considered and recommends a format for the documentation necessary for adequate interface control. Chapter 3, The Process: Through the Design Phases, provides tailored guidance for interface definition and control. This manual can be used to improve planned or existing interface control processes during system design and development. It can also be used to refresh and update the corporate knowledge base. The information presented herein will reduce the amount of paper and data required in interface definition and control processes by as much as 50 percent and will shorten the time required to prepare an interface control document. It also highlights the essential technical parameters that ensure that flight subsystems will indeed fit together and function as intended after assembly and checkout.

40 CFR Table 1b to Subpart Zzzz of... - Operating Limitations for Existing, New, and Reconstructed SI 4SRB Stationary RICE >500 HP...

Code of Federal Regulations, 2013 CFR

2013-07-01

..., New, and Reconstructed SI 4SRB Stationary RICE >500 HP Located at a Major Source of HAP Emissions 1b... Limitations for Existing, New, and Reconstructed SI 4SRB Stationary RICE >500 HP Located at a Major Source of... 15 percent O2 and using NSCR; a. maintain your catalyst so that the pressure drop across the catalyst...

40 CFR Table 1b to Subpart Zzzz of... - Operating Limitations for Existing, New, and Reconstructed SI 4SRB Stationary RICE >500 HP...

Code of Federal Regulations, 2014 CFR

2014-07-01

..., New, and Reconstructed SI 4SRB Stationary RICE >500 HP Located at a Major Source of HAP Emissions 1b... Limitations for Existing, New, and Reconstructed SI 4SRB Stationary RICE >500 HP Located at a Major Source of... 15 percent O2 and using NSCR; a. maintain your catalyst so that the pressure drop across the catalyst...

40 HP Electro-Mechanical Actuator

NASA Technical Reports Server (NTRS)

Fulmer, Chris

1996-01-01

This report summarizes the work performed on the 40 BP electro-mechanical actuator (EMA) system developed on NASA contract NAS3-25799 for the NASA National Launch System and Electrical Actuation (ELA) Technology Bridging Programs. The system was designed to demonstrate the capability of large, high power linear ELA's for applications such as Thrust Vector Control (TVC) on rocket engines. It consists of a motor controller, high frequency power source, drive electronics and a linear actuator. The power source is a 25kVA 20 kHz Mapham inverter. The drive electronics are based on the pulse population modulation concept and operate at a nominal frequency of 40 kHz. The induction motor is a specially designed high speed, low inertia motor capable of a 68 peak HP. The actuator was originally designed by MOOG Aerospace under an internal R & D program to meet Space Shuttle Main Engine (SSME) TVC requirements. The design was modified to meet this programs linear rate specification of 7.4 inches/second. The motor and driver were tested on a dynamometer at the Martin Marietta Space Systems facility. System frequency response and step response tests were conducted at the Marshall Space Flight Center facility. A complete description of the system and all test results can be found in the body of the report.

Improving the quality of child anthropometry: Manual anthropometry in the Body Imaging for Nutritional Assessment Study (BINA).

PubMed

Conkle, Joel; Ramakrishnan, Usha; Flores-Ayala, Rafael; Suchdev, Parminder S; Martorell, Reynaldo

2017-01-01

Anthropometric data collected in clinics and surveys are often inaccurate and unreliable due to measurement error. The Body Imaging for Nutritional Assessment Study (BINA) evaluated the ability of 3D imaging to correctly measure stature, head circumference (HC) and arm circumference (MUAC) for children under five years of age. This paper describes the protocol for and the quality of manual anthropometric measurements in BINA, a study conducted in 2016-17 in Atlanta, USA. Quality was evaluated by examining digit preference, biological plausibility of z-scores, z-score standard deviations, and reliability. We calculated z-scores and analyzed plausibility based on the 2006 WHO Child Growth Standards (CGS). For reliability, we calculated intra- and inter-observer Technical Error of Measurement (TEM) and Intraclass Correlation Coefficient (ICC). We found low digit preference; 99.6% of z-scores were biologically plausible, with z-score standard deviations ranging from 0.92 to 1.07. Total TEM was 0.40 for stature, 0.28 for HC, and 0.25 for MUAC in centimeters. ICC ranged from 0.99 to 1.00. The quality of manual measurements in BINA was high and similar to that of the anthropometric data used to develop the WHO CGS. We attributed high quality to vigorous training, motivated and competent field staff, reduction of non-measurement error through the use of technology, and reduction of measurement error through adequate monitoring and supervision. Our anthropometry measurement protocol, which builds on and improves upon the protocol used for the WHO CGS, can be used to improve anthropometric data quality. The discussion illustrates the need to standardize anthropometric data quality assessment, and we conclude that BINA can provide a valuable evaluation of 3D imaging for child anthropometry because there is comparison to gold-standard, manual measurements.

Improving the quality of child anthropometry: Manual anthropometry in the Body Imaging for Nutritional Assessment Study (BINA)

PubMed Central

2017-01-01

Anthropometric data collected in clinics and surveys are often inaccurate and unreliable due to measurement error. The Body Imaging for Nutritional Assessment Study (BINA) evaluated the ability of 3D imaging to correctly measure stature, head circumference (HC) and arm circumference (MUAC) for children under five years of age. This paper describes the protocol for and the quality of manual anthropometric measurements in BINA, a study conducted in 2016–17 in Atlanta, USA. Quality was evaluated by examining digit preference, biological plausibility of z-scores, z-score standard deviations, and reliability. We calculated z-scores and analyzed plausibility based on the 2006 WHO Child Growth Standards (CGS). For reliability, we calculated intra- and inter-observer Technical Error of Measurement (TEM) and Intraclass Correlation Coefficient (ICC). We found low digit preference; 99.6% of z-scores were biologically plausible, with z-score standard deviations ranging from 0.92 to 1.07. Total TEM was 0.40 for stature, 0.28 for HC, and 0.25 for MUAC in centimeters. ICC ranged from 0.99 to 1.00. The quality of manual measurements in BINA was high and similar to that of the anthropometric data used to develop the WHO CGS. We attributed high quality to vigorous training, motivated and competent field staff, reduction of non-measurement error through the use of technology, and reduction of measurement error through adequate monitoring and supervision. Our anthropometry measurement protocol, which builds on and improves upon the protocol used for the WHO CGS, can be used to improve anthropometric data quality. The discussion illustrates the need to standardize anthropometric data quality assessment, and we conclude that BINA can provide a valuable evaluation of 3D imaging for child anthropometry because there is comparison to gold-standard, manual measurements. PMID:29240796

An h-p Taylor-Galerkin finite element method for compressible Euler equations

NASA Technical Reports Server (NTRS)

Demkowicz, L.; Oden, J. T.; Rachowicz, W.; Hardy, O.

1991-01-01

An extension of the familiar Taylor-Galerkin method to arbitrary h-p spatial approximations is proposed. Boundary conditions are analyzed, and a linear stability result for arbitrary meshes is given, showing the unconditional stability for the parameter of implicitness alpha not less than 0.5. The wedge and blunt body problems are solved with both linear, quadratic, and cubic elements and h-adaptivity, showing the feasibility of higher orders of approximation for problems with shocks.

Acquisition of dental skills in preclinical technique courses: influence of spatial and manual abilities.

PubMed

Schwibbe, Anja; Kothe, Christian; Hampe, Wolfgang; Konradt, Udo

2016-10-01

Sixty years of research have not added up to a concordant evaluation of the influence of spatial and manual abilities on dental skill acquisition. We used Ackerman's theory of ability determinants of skill acquisition to explain the influence of spatial visualization and manual dexterity on the task performance of dental students in two consecutive preclinical technique courses. We measured spatial and manual abilities of applicants to Hamburg Dental School by means of a multiple choice test on Technical Aptitude and a wire-bending test, respectively. Preclinical dental technique tasks were categorized as consistent-simple and inconsistent-complex based on their contents. For analysis, we used robust regression to circumvent typical limitations in dental studies like small sample size and non-normal residual distributions. We found that manual, but not spatial ability exhibited a moderate influence on the performance in consistent-simple tasks during dental skill acquisition in preclinical dentistry. Both abilities revealed a moderate relation with the performance in inconsistent-complex tasks. These findings support the hypotheses which we had postulated on the basis of Ackerman's work. Therefore, spatial as well as manual ability are required for the acquisition of dental skills in preclinical technique courses. These results support the view that both abilities should be addressed in dental admission procedures in addition to cognitive measures.

Evaluating Gaia performances on eclipsing binaries. IV. Orbits and stellar parameters for SV Cam, BS Dra and HP Dra

NASA Astrophysics Data System (ADS)

Milone, E. F.; Munari, U.; Marrese, P. M.; Williams, M. D.; Zwitter, T.; Kallrath, J.; Tomov, T.

2005-10-01

This is the fourth in a series of papers that aim both to provide reasonable orbits for a number of eclipsing binaries and to evaluate the expected performance of Gaia of these objects and the accuracy that is achievable in the determination of such fundamental stellar parameters as mass and radius. In this paper, we attempt to derive the orbits and physical parameters for three eclipsing binaries in the mid-F to mid-G spectral range. As for previous papers, only the H_P, V_T, BT photometry from the Hipparcos/Tycho mission and ground-based radial velocities from spectroscopy in the region 8480-8740 Å are used in the analyses. These data sets simulate the photometric and spectroscopic data that are expected to be obtained by Gaia, the approved ESA Cornerstone mission to be launched in 2011. The systems targeted in this paper are SV Cam, BS Dra and HP Dra. SV Cam and BS Dra have been studied previously, allowing comparisons of the derived parameters with those from full scale and devoted ground-based investigations. HP Dra has no published orbital solution. SV Cam has a β Lyrae type light curve and the others have Algol-like light curves. SV Cam has the complication of light curve anomalies, usually attributed to spots; BS Dra has non-solar metallicity, and HP Dra appears to have a small eccentricity and a sizeable time derivative in the argument of the periastron. Thus all three provide interesting and different test cases.

Structures manual

DOT National Transportation Integrated Search

2001-01-01

This manual was written as a guide for use by design personnel in the Vermont Agency of Transportation Structures Section. This manual covers the design responsibilities of the Section. It does not cover other functions that are a part of the Structu...

Ciencias 2. Manual do Professor (Science Teacher's Manual).

ERIC Educational Resources Information Center

Raposo, Lucilia

This is the teacher's manual for Ciencias 2, the second in a series of elementary science textbooks for Portuguese-speaking students. The student textbook contains 10 chapters and 57 activities. The teacher's manual presents an explanation of the educational goals and the organization of the content, Topics included are environment, the human,…

25 Gbps 850 nm photodiode for emerging 100 Gb ethernet applications

NASA Astrophysics Data System (ADS)

Joshi, Abhay; Rue, Jim; Becker, Don; Datta, Shubhashish; McFaul, Will

2011-06-01

The IEEE Std 802.3ba-2010 for 40 Gb and 100 Gb Ethernet was released in July, 2010. This standard will continue to evolve over the next several years. Two of the challenging transmit/receive architectures contained in this standard are the 100GBASE-LR4 (<10 km range) and 100GBASE-ER4 (<40 km range). Although presently envisioned for 1310 nm optical wavelengths, both of these 4 lane, 25.78 GBaud formats may be adopted for the impending 850 nm short reach optical backplane market, whose range is below 150 m. Driven by major computer server companies, such as IBM, HP and Oracle, the 850 nm Active Optical Cable (AOC) market is presently undergoing an increase of serial rates up to 25 Gbaud to enhance backplane interconnectivity. With AOCs up to 16 channels, the potential for up to 400 Gbps backhaul composite data rates will soon be possible. We report a 25 Gbps photodiode with quantum efficiency ~ 0.6 at 850 nm. This InGaAs/InP device was optimized for high quantum efficiency at 850 nm. When pigtailed with multimode fiber and integrated with an application-specific RF amplifier, the resultant photoreceiver will provide multiple functionalities for these 100 Gb Ethernet markets.

Effects of Retinal Eccentricity on Human Manual Control

NASA Technical Reports Server (NTRS)

Popovici, Alexandru; Zaal, Peter M. T.

2017-01-01

This study investigated the effects of viewing a primary flight display at different retinal eccentricities on human manual control behavior and performance. Ten participants performed a pitch tracking task while looking at a simplified primary flight display at different horizontal and vertical retinal eccentricities, and with two different controlled dynamics. Tracking performance declined at higher eccentricity angles and participants behaved more nonlinearly. The visual error rate gain increased with eccentricity for single-integrator-like controlled dynamics, but decreased for double-integrator-like dynamics. Participants' visual time delay was up to 100 ms higher at the highest horizontal eccentricity compared to foveal viewing. Overall, vertical eccentricity had a larger impact than horizontal eccentricity on most of the human manual control parameters and performance. Results might be useful in the design of displays and procedures for critical flight conditions such as in an aerodynamic stall.

Partial Red Blood Cell Exchange in Children and Young Patients with Sickle Cell Disease: Manual Versus Automated Procedure.

PubMed

Escobar, Carlos; Moniz, Marta; Nunes, Pedro; Abadesso, Clara; Ferreira, Teresa; Barra, António; Lichtner, Anabela; Loureiro, Helena; Dias, Alexandra; Almeida, Helena

2017-10-31

The benefits of manual versus automated red blood cell exchange have rarely been documented and studies in young sickle cell disease patients are scarce. We aim to describe and compare our experience in these two procedures. Young patients (≤ 21 years old) who underwent manual- or automated-red blood cell exchange for prevention or treatment of sickle cell disease complications were included. Clinical, technical and hematological data were prospectively recorded and analyzed. Ninety-four red blood cell exchange sessions were performed over a period of 68 months, including 57 manual and 37 automated, 63 for chronic complications prevention, 30 for acute complications and one in the pre-operative setting. Mean decrease in sickle hemoglobin levels was higher in automated-red blood cell exchange (p < 0.001) and permitted a higher sickle hemoglobin level decrease per volume removed (p < 0.001), while hemoglobin and hematocrit remained stable. Ferritin levels on chronic patients decreased 54%. Most frequent concern was catheter outflow obstruction on manual-red blood cell exchange and access alarm on automated-red blood cell exchange. No major complication or alloimunization was recorded. Automated-red blood cell exchange decreased sickle hemoglobin levels more efficiently than manual procedure in the setting of acute and chronic complications of sickle cell disease, with minor technical concerns mainly due to vascular access. The threshold of sickle hemoglobin should be individualized for clinical and hematological goals. In our cohort of young patients, the need for an acceptable venous access was a limiting factor, but iron-overload was avoided. Automated red blood cell exchange is safe and well tolerated. It permits a higher sickle hemoglobin removal efficacy, better volume status control and iron-overload avoidance.

Preparation of Effective Operating Manuals to Support Waste Management Plant Operator Training

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, S. R.

2003-02-25

Effective plant operating manuals used in a formal training program can make the difference between a successful operation and a failure. Once the plant process design and control strategies have been fixed, equipment has been ordered, and the plant is constructed, the only major variable affecting success is the capability of plant operating personnel. It is essential that the myriad details concerning plant operation are documented in comprehensive operating manuals suitable for training the non-technical personnel that will operate the plant. These manuals must cover the fundamental principles of each unit operation including how each operates, what process variables aremore » important, and the impact of each variable on the overall process. In addition, operators must know the process control strategies, process interlocks, how to respond to alarms, each of the detailed procedures required to start up and optimize the plant, and every control loop-including when it is appropriate to take manual control. More than anything else, operating mistakes during the start-up phase can lead to substantial delays in achieving design processing rates as well as to problems with government authorities if environmental permit limits are exceeded. The only way to assure return on plant investment is to ensure plant operators have the knowledge to properly run the plant from the outset. A comprehensive set of operating manuals specifically targeted toward plant operators and supervisors written by experienced operating personnel is the only effective way to provide the necessary information for formal start-up training.« less

[Stapler versus manual anastomosis in gastrointestinal surgery].

PubMed

Moreno-Gonzalez, E; Vara-Thorbeck, R

1987-01-01

The comparative effectiveness of manual and auto-sutured anastomoses after total gastrectomy (107 cases), low anterior rectal resection (100 cases) and right hemicolectomy (34 cases) is studied. In the stapled series the incidence of anastomotic leakage was somewhat less, although benign stenosis occurred more frequently than with hand-sutured anastomoses. However, this could not be statistically demonstrated. In the authors' view, the main advantages of the use of staplers are the shortening of operating time and the lessening of septic steps.

Irrigation Training Manual. Planning, Design, Operation, and Management of Small-Scale Irrigation Systems [and] Irrigation Reference Manual. A Technical Reference to Be Used with the Peace Corps Irrigation Training Manual T0076 in the Selection, Planning, Design, Operation, and Management of Small-Scale Irrigation Systems.

ERIC Educational Resources Information Center

Salazar, LeRoy; And Others

This resource for trainers involved in irrigated agriculture training for Peace Corps volunteers consists of two parts: irrigation training manual and irrigation reference manual. The complete course should fully prepare volunteers serving as irrigation, specialists to plan, implement, evaluate and manage small-scale irrigation projects in arid,…

Diversification of HP1-like Chromo Domain Proteins in Tetrahymena thermophila.

PubMed

Wiley, Emily A; Horrell, Scott; Yoshino, Alyssa; Schornak, Cara C; Bagnani, Claire; Chalker, Douglas L

2018-01-01

Proteins that possess a chromo domain are well-known for their roles in heterochromatin assembly and maintenance. The Heterochromatin Protein 1 (HP1) family, with a chromo domain and carboxy-terminal chromo shadow domain, targets heterochromatin through interaction with histone H3 methylated on lysine 9 (H3K9me2/3). The structural and functional diversity of these proteins observed in both fission yeast and metazoans correlate with chromatin specialization. To expand these studies, we examined chromo domain proteins in the ciliate Tetrahymena thermophila, which has functionally diverse and developmentally regulated heterochromatin domains. We identified thirteen proteins similar to HP1. Together they possess only a fraction of the possible chromo domain subtypes and most lack a recognizable chromo shadow domain. Using fluorescence microscopy to track chromatin localization of tagged proteins through the life cycle, we show evidence that in T. thermophila this family has diversified with biological roles in RNAi-directed DNA elimination, germline genome structure, and somatic heterochromatin. Those proteins with H3K27me3 binding sequence characteristics localize to chromatin in mature nuclei, whereas those with H3K9me2/3 binding characteristics localize to developing nuclei undergoing DNA elimination. Findings point to an expanded and diversified family of chromo domain proteins that parallels heterochromatin diversity in ciliates. © 2017 The Authors. Journal of Eukaryotic Microbiology published by Wiley Periodicals, Inc. on behalf of International Society of Protistologists.

INDEPENDENT TECHNICAL REVIEW OF THE BUILDING 100 PLUME, FORMER DOE PINELLAS SITE (YOUNG - RAINEY STAR CENTER), LARGO, FLORIDA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eddy-Dilek, C.; Rossabi, J.; Amidon, M.

2010-07-30

Contaminated groundwater associated with Building 100 at the Young-Rainey Science, Technology, and Research Center, formerly the DOE Pinellas plant, is the primary remedial challenge that remains to be addressed at the site. Currently, Building 100 is an active industrial facility that is now owned and operated by the Pinellas county government. Groundwater samples collected from monitoring wells recently installed near the southern boundary of the site suggest that contaminated groundwater has migrated off the plant site. In response to the challenges presented by the Building 100 plume, the Office of Legacy Management (LM) requested assistance from the DOE Office ofmore » Groundwater and Soil Remediation (EM-32) to provide a review team to make technical recommendations so that they can efficiently and effectively address characterization and remediation of the plume. The review team was unanimous in the conclusion that a dynamic strategy that combines a phased implementation of direct push samplers, sensors, and tools can be used to better delineate the extent of contamination, control plume migration, and rapidly remediate the contaminated groundwater at the site. The initial efforts of the team focused on reviewing the site history and data, organizing the information into a conceptual model, identifying appropriate technologies, and recommending an integrated strategy. The current groundwater data from the site indicate a two-lobed plume extending to the east and south. To the east vinyl chloride is the primary contaminant of concern, to the south, vinyl chloride and cis1, 2-DCE are the primary contaminants. The limited data that are available suggest that reductive dechlorination of the TCE is already occurring but is not sufficient to prevent offsite migration of low concentrations of TCE daughter products. The team recommends that DOE pursue a strategy that builds on the natural cleansing capacity of the subsurface with reductive methods including

Manually Classifying User Search Queries on an Academic Library Web Site

ERIC Educational Resources Information Center

Chapman, Suzanne; Desai, Shevon; Hagedorn, Kat; Varnum, Ken; Mishra, Sonali; Piacentine, Julie

2013-01-01

The University of Michigan Library wanted to learn more about the kinds of searches its users were conducting through the "one search" search box on the Library Web site. Library staff conducted two investigations. A preliminary investigation in 2011 involved the manual review of the 100 most frequently occurring queries conducted…

[Manual and mechanic anastomosis. Comparison in oncologic surgery of the colon and rectum].

PubMed

Piccolomini, A; Bruttini, S; Di Cosmo, L; Carli, A F; Guarnieri, A; Mariani, L; Carli, A

1990-03-15

Personal experience in the treatment of 60 cases of cancer of the large bowel with left hemicolon and rectal localisation is reported. 20 manual double layer anastomoses (group I), 20 single layer (group II) and with mechanical stapler (EEA stapler) (group III) were carried out in consecutive series. The results are reported in terms of early local and general complications: specifically 13 cases of anastomotic dehiscence of which 69.2% were observed in group I, 15.4% in group II and 15.4% in group III. Total postoperative mortality was 5%, average hospitalisation was as follows: 19 days group I, 14 days group II, 17 days group III. The value of single layer anastomoses, which is comparable to results with the stapler whose use is essential in cases of real manual technical difficulty, is stressed.

Engineering and Technical Education in Russia, in Numbers

ERIC Educational Resources Information Center

Aref'ev, A. L.; Aref'ev, M. A.

2013-01-01

An analysis of the main tendencies in the development of engineering and technical education in Russia during the last 100 years shows that earlier strengths have been lost, and that currently technical education in Russia is far behind modern world standards.

Fuzzy physical programming for Space Manoeuvre Vehicles trajectory optimization based on hp-adaptive pseudospectral method

NASA Astrophysics Data System (ADS)

Chai, Runqi; Savvaris, Al; Tsourdos, Antonios

2016-06-01

In this paper, a fuzzy physical programming (FPP) method has been introduced for solving multi-objective Space Manoeuvre Vehicles (SMV) skip trajectory optimization problem based on hp-adaptive pseudospectral methods. The dynamic model of SMV is elaborated and then, by employing hp-adaptive pseudospectral methods, the problem has been transformed to nonlinear programming (NLP) problem. According to the mission requirements, the solutions were calculated for each single-objective scenario. To get a compromised solution for each target, the fuzzy physical programming (FPP) model is proposed. The preference function is established with considering the fuzzy factor of the system such that a proper compromised trajectory can be acquired. In addition, the NSGA-II is tested to obtain the Pareto-optimal solution set and verify the Pareto optimality of the FPP solution. Simulation results indicate that the proposed method is effective and feasible in terms of dealing with the multi-objective skip trajectory optimization for the SMV.

Silent decision: HP1 protein escorts heterochromatic RNAs to their destiny

PubMed Central

Ren, Jie; Martienssen, Robert A

2012-01-01

EMBO J advance online publication 06072012; doi:10.1016/j.molcel.2012.05.009 Heterochromatin is classically perceived to be refractory to transcription because of its compact structure. However, Keller et al (2012) now demonstrated that heterochromatic transcripts can accumulate even when heterochromatin is normally packaged. By tracking down the fate of these heterochromatic RNAs, they revealed a new post-transcriptional mechanism of silencing in heterochromatin that involves the dynamic turnover of HP1Swi6 between its free, chromatin-bound and RNA-bound forms. The latter form escorts heterochromatic RNA to degradation. PMID:22705945

Operational and maintenance instruction manual for the Ingham County Geriatric Medical Care Facility solar water-heating system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Ingham County solar system consists of approximately 10,000 square feet of solar collectors connected in a closed configuration loop. The primary loop solution is a 1:12 mixture of water and propylene glycol which flows through the tube side of a heat exchanger connected to the primary storage tank. The heat energy which is supplied to the primary storage tank is subsequently used to preheat the temperature of the laundry water, kitchen water, and domestic potable water. Included in this report are: detailed drawings and flow chart; operational methodology; preventive maintenance instructions; general instructions and safety precautions; and a correctivemore » maintenance and tabulation of failure modes. Appendices include: manufacturers technical manual and component specifications; IBM data sensors and responsibilities; digital county monitor operations manual; and on site monitor operations manual. Reference CAPE-2834. (LS)« less

Creep Laboratory manual

NASA Astrophysics Data System (ADS)

Osgerby, S.; Loveday, M. S.

1992-06-01

A manual for the NPL Creep Laboratory, a collective name given to two testing laboratories, the Uniaxial Creep Laboratory and the Advanced High Temperature Mechanical Testing Laboratory, is presented. The first laboratory is devoted to uniaxial creep testing and houses approximately 50 high sensitivity creep machines including 10 constant stress cam lever machines. The second laboratory houses a low cycle fatigue testing machine of 100 kN capacity driven by a servo-electric actuator, five machines for uniaxial tensile creep testing of engineering ceramics at temperatures up to 1600C, and an electronic creep machine. Details of the operational procedures for carrying out uniaxial creep testing are given. Calibration procedures to be followed in order to comply with the specifications laid down by British standards, and to provide traceability back to the primary standards are described.

Time transfer between the Goddard Optical Research Facility and the U.S. Naval Observatory using 100 picosecond laser pulses

NASA Technical Reports Server (NTRS)

Alley, C. O.; Rayner, J. D.; Steggerda, C. A.; Mullendore, J. V.; Small, L.; Wagner, S.

1983-01-01

A horizontal two-way time comparison link in air between the University of Maryland laser ranging and time transfer equipment at the Goddard Optical Research Facility (GORF) 1.2 m telescope and the Time Services Division of the U.S. Naval Observatory (USNO) was established. Flat mirrors of 25 cm and 30 cm diameter respectively were placed on top of the Washington Cathedral and on a water tower at the Beltsville Agricultural Research Center. Two optical corner reflectors at the USNO reflect the laser pulses back to the GORF. Light pulses of 100 ps duration and an energy of several hundred microjoules are sent at the rate of 10 pulses per second. The detection at the USNO is by means of an RCA C30902E avalanche photodiode and the timing is accomplished by an HP 5370A computing counter and an HP 1000 computer with respect to a 10 pps pulse train from the Master Clock.

Perspectives on Industrial Innovation from Agilent, HP, and Bell Labs

NASA Astrophysics Data System (ADS)

Hollenhorst, James

2014-03-01

Innovation is the life blood of technology companies. I will give perspectives gleaned from a career in research and development at Bell Labs, HP Labs, and Agilent Labs, from the point of view of an individual contributor and a manager. Physicists bring a unique set of skills to the corporate environment, including a desire to understand the fundamentals, a solid foundation in physical principles, expertise in applied mathematics, and most importantly, an attitude: namely, that hard problems can be solved by breaking them into manageable pieces. In my experience, hiring managers in industry seldom explicitly search for physicists, but they want people with those skills.

Technical Guidelines and References: Crops Training Component. From: Agricultural Development Workers Training Manual. Volume III: Crops.

ERIC Educational Resources Information Center

Peace Corps, Washington, DC. Information Collection and Exchange Div.

This reference manual for training Peace Corps agricultural development workers deals with crops. The document begins with common units of area, length, weight, volume, and conversions between them. A practice problem is worked and other conversion problems are given. The second section is intended to show agricultural field workers how to survey…

Patterns of technical error among surgical malpractice claims: an analysis of strategies to prevent injury to surgical patients.

PubMed

Regenbogen, Scott E; Greenberg, Caprice C; Studdert, David M; Lipsitz, Stuart R; Zinner, Michael J; Gawande, Atul A

2007-11-01

To identify the most prevalent patterns of technical errors in surgery, and evaluate commonly recommended interventions in light of these patterns. The majority of surgical adverse events involve technical errors, but little is known about the nature and causes of these events. We examined characteristics of technical errors and common contributing factors among closed surgical malpractice claims. Surgeon reviewers analyzed 444 randomly sampled surgical malpractice claims from four liability insurers. Among 258 claims in which injuries due to error were detected, 52% (n = 133) involved technical errors. These technical errors were further analyzed with a structured review instrument designed by qualitative content analysis. Forty-nine percent of the technical errors caused permanent disability; an additional 16% resulted in death. Two-thirds (65%) of the technical errors were linked to manual error, 9% to errors in judgment, and 26% to both manual and judgment error. A minority of technical errors involved advanced procedures requiring special training ("index operations"; 16%), surgeons inexperienced with the task (14%), or poorly supervised residents (9%). The majority involved experienced surgeons (73%), and occurred in routine, rather than index, operations (84%). Patient-related complexities-including emergencies, difficult or unexpected anatomy, and previous surgery-contributed to 61% of technical errors, and technology or systems failures contributed to 21%. Most technical errors occur in routine operations with experienced surgeons, under conditions of increased patient complexity or systems failure. Commonly recommended interventions, including restricting high-complexity operations to experienced surgeons, additional training for inexperienced surgeons, and stricter supervision of trainees, are likely to address only a minority of technical errors. Surgical safety research should instead focus on improving decision-making and performance in routine

VERU-SOLVE™ MARINE 200 HP

EPA Pesticide Factsheets

Technical product bulletin: this surface washing agent used in oil spill cleanups separates the oil and water from the sand or soiled surface. Suitable for treating shorelines, beaches, rocks, marshes, sensitive environments, and access limited areas.

Air Force Research Laboratory Wright Site Guide to Technical Publishing

DTIC Science & Technology

2005-04-01

Scientific and Technical Reports—Elements, Organization, and Design manual (and a version modified for documents generated for AFRL) • Merriam-Webster’s...notice page --SF 298 --original graphics /halftones Indicate the following on the letter of transmittal sheet: --quantity of copies required for...Elements, Organization and Design ? The WRS CDRL for a final report requires that the standard be followed. The only exception is SBIR Phase 1

Terminology Manual.

ERIC Educational Resources Information Center

Felber, Helmut

A product of the International Information Center for Terminology (Infoterm), this manual is designed to serve as a reference tool for practitioners active in terminology work and documentation. The manual explores the basic ideas of the Vienna School of Terminology and explains developments in the area of applied computer aided terminography…

Mua (HP0868) Is a Nickel-Binding Protein That Modulates Urease Activity in Helicobacter pylori

PubMed Central

Benoit, Stéphane L.; Maier, Robert J.

2011-01-01

A novel mechanism aimed at controlling urease expression in Helicobacter pylori in the presence of ample nickel is described. Higher urease activities were observed in an hp0868 mutant (than in the wild type) in cells supplemented with nickel, suggesting that the HP0868 protein (herein named Mua for modulator of urease activity) represses urease activity when nickel concentrations are ample. The increase in urease activity in the Δmua mutant was linked to an increase in urease transcription and synthesis, as shown by quantitative real-time PCR, SDS-PAGE, and immunoblotting against UreAB. Increased urease synthesis was also detected in a Δmua ΔnikR double mutant strain. The Δmua mutant was more sensitive to nickel toxicity but more resistant to acid challenge than was the wild-type strain. Pure Mua protein binds 2 moles of Ni2+ per mole of dimer. Electrophoretic mobility shift assays did not reveal any binding of Mua to the ureA promoter or other selected promoters (nikR, arsRS, 5′ ureB-sRNAp). Previous yeast two-hybrid studies indicated that Mua and RpoD may interact; however, only a weak interaction was detected via cross-linking with pure components and this could not be verified by another approach. There was no significant difference in the intracellular nickel level between wild-type and mua mutant cells. Taken together, our results suggest the HP0868 gene product represses urease transcription when nickel levels are high through an as-yet-uncharacterized mechanism, thus counterbalancing the well-described NikR-mediated activation. PMID:21505055

High Power Diode Laser-Treated HP-HVOF and Twin Wire Arc-Sprayed Coatings for Fossil Fuel Power Plants

NASA Astrophysics Data System (ADS)

Mann, B. S.

2013-08-01

This article deals with high power diode laser (HPDL) surface modification of twin wire arc-sprayed (TWAS) and high pressure high velocity oxy-fuel (HP-HVOF) coatings to combat solid particle erosion occurring in fossil fuel power plants. To overcome solid particle impact wear above 673 K, Cr3C2-NiCr-, Cr3C2-CoNiCrAlY-, and WC-CrC-Ni-based HVOF coatings are used. WC-CoCr-based HVOF coatings are generally used below 673 K. Twin wire arc (TWA) spraying of Tafa 140 MXC and SHS 7170 cored wires is used for a wide range of applications for a temperature up to 1073 K. Laser surface modification of high chromium stainless steels for steam valve components and LPST blades is carried out regularly. TWA spraying using SHS 7170 cored wire, HP-HVOF coating using WC-CoCr powder, Ti6Al4V alloy, and high chromium stainless steels (X20Cr13, AISI 410, X10CrNiMoV1222, 13Cr4Ni, 17Cr4Ni) were selected in the present study. Using robotically controlled parameters, HPDL surface treatments of TWAS-coated high strength X10CrNiMoV1222 stainless steel and HP-HVOF-coated AISI 410 stainless steel samples were carried out and these were compared with HPDL-treated high chromium stainless steels and titanium alloy for high energy particle impact wear (HEPIW) resistance. The HPDL surface treatment of the coatings has improved the HEPIW resistance manifold. The improvement in HPDL-treated stainless steels and titanium alloys is marginal and it is not comparable with that of HPDL-treated coatings. These coatings were also compared with "as-sprayed" coatings for fracture toughness, microhardness, microstructure, and phase analyses. The HEPIW resistance has a strong relationship with the product of fracture toughness and microhardness of the HPDL-treated HP-HVOF and TWAS SHS 7170 coatings. This development opens up a possibility of using HPDL surface treatments in specialized areas where the problem of HEPIW is very severe. The HEPIW resistance of HPDL-treated high chromium stainless steels and

Gastroenterology-Urology Devices; Manual Gastroenterology-Urology Surgical Instruments and Accessories. Final rule; technical amendment.

PubMed

2017-03-01

The Food and Drug Administration (FDA) is amending the identification of manual gastroenterology-urology surgical instruments and accessories to reflect that the device does not include specialized surgical instrumentation for use with urogyencologic surgical mesh specifically intended for use as an aid in the insertion, placement, fixation, or anchoring of surgical mesh during urogynecologic procedures ("specialized surgical instrumentation for use with urogynecologic surgical mesh"). These amendments are being made to reflect changes made in the recently issued final reclassification order for specialized surgical instrumentation for use with urogynecologic surgical mesh.

Nutrient Control Design Manual

EPA Science Inventory

The purpose of this EPA design manual is to provide updated, state‐of‐the‐technology design guidance on nitrogen and phosphorus control at municipal Wastewater Treatment Plants (WWTPs). Similar to previous EPA manuals, this manual contains extensive information on the principles ...

Hazard House Workbook: A Workbook about Household Chemicals. Leader's Manual. Members Manual.

ERIC Educational Resources Information Center

California State Dept. of Toxic Substance Control, Sacramento.

The two books, the leader's manual and the members' manual address one environmental problem people come into contact with on a daily basis: potentially hazardous household products. The purpose of the books is to educate community groups about hazardous materials. The member's manual shares information about hazardous items and provides facts to…

Camp Health Aide Manual = Manual para trabajadores de salud.

ERIC Educational Resources Information Center

Robinson, June Grube; And Others

This bilingual manual serves as a textbook for migrant Camp Health Aides. Camp Health Aides are members of migrant labor camps enlisted to provide information about health and social services to migrant workers and their families. The manual is divided into 12 tabbed sections representing lessons. Teaching notes printed on contrasting paper…

28 CFR 34.100 - Purpose and applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 262(d)(2) of the Juvenile Justice and Delinquency Prevention Act of 1974, as amended. This provision... 34.100 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES... of the Department of Justice) in fields related to the technical and/or subject matter of the...

28 CFR 34.100 - Purpose and applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 262(d)(2) of the Juvenile Justice and Delinquency Prevention Act of 1974, as amended. This provision... 34.100 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES... of the Department of Justice) in fields related to the technical and/or subject matter of the...

28 CFR 34.100 - Purpose and applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 262(d)(2) of the Juvenile Justice and Delinquency Prevention Act of 1974, as amended. This provision... 34.100 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES... of the Department of Justice) in fields related to the technical and/or subject matter of the...

28 CFR 34.100 - Purpose and applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 262(d)(2) of the Juvenile Justice and Delinquency Prevention Act of 1974, as amended. This provision... 34.100 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES... of the Department of Justice) in fields related to the technical and/or subject matter of the...

Radiographic technical quality of root canal treatment performed ex vivo by dental students at Valencia University Medical and Dental School, Spain

PubMed Central

Faus-Matoses, Vicente; Alegre-Domingo, Teresa; Faus-Llácer, Vicente J.

2014-01-01

Objectives: To evaluate radiographically the quality of root canal fillings and compare manual and rotary preparation performed on extracted teeth by undergraduate dental students. Study Design: A total of 561 premolars and molars extracted teeth were prepared using nickel-titanium rotary files or manual instrumentation and filled with gutta-percha using a cold lateral condensation technique, by 4th grade undergraduate students. Periapical radiographs were used to assess the technical quality of the root canal filling, evaluating three variables: length, density and taper. These data were recorded, scored and used to study the “technical success rate” and the “overall score”. The length of each root canal filling was classified as acceptable, short and overfilled, based on their relationship with the radiographic apex. Density and taper of filling were evaluated based on the presence of voids and the uniform tapering of the filling, respectively. Statistical analysis was used to evaluate the quality of root canal treatment, considering p < 0.05 as a statistical significant level. Results: The percentage of technical success was 44% and the overall score was 7.8 out of 10. Technical success and overall score were greater with rotary instruments (52% against 28% with a manual one, p < 0.001; 8.3 against 6.7 respectively, p < 0.001). Conclusions: It appears that inexperienced operators perform better root canal treatment (RCT) with the use of rotary instrumentation. Key words:Dental education, endodontics, rotary instrumentation, radiographs, root canal treatment, undergraduate students. PMID:24121911

Technical approaches for measurement of human errors

NASA Technical Reports Server (NTRS)

Clement, W. F.; Heffley, R. K.; Jewell, W. F.; Mcruer, D. T.

1980-01-01

Human error is a significant contributing factor in a very high proportion of civil transport, general aviation, and rotorcraft accidents. The technical details of a variety of proven approaches for the measurement of human errors in the context of the national airspace system are presented. Unobtrusive measurements suitable for cockpit operations and procedures in part of full mission simulation are emphasized. Procedure, system performance, and human operator centered measurements are discussed as they apply to the manual control, communication, supervisory, and monitoring tasks which are relevant to aviation operations.

Reader-Centered Technical Writing

NASA Astrophysics Data System (ADS)

Narayanan, M.

2012-12-01

Technical writing is an essential part of professional communication and in recent years it has shifted from a genre-based approach. Formerly, technical writing primarily focused on generating templates of documents and sometimes it was creating or reproducing traditional forms with minor modifications and updates. Now, technical writing looks at the situations surrounding the need to write. This involves deep thinking about the goals and objectives of the project on hand. Furthermore, one observes that it is very important for any participatory process to have the full support of management. This support needs to be well understood and believed by employees. Professional writing may be very persuasive in some cases. When presented in the appropriate context, technical writing can persuade a company to improve work conditions ensuring employee safety and timely production. However, one must recognize that lot of professional writing still continues to make use of reports and instruction manuals. Normally, technical and professional writing addresses four aspects. Objective: The need for generating a given professionally written technical document and the goals the document is expected to achieve and accomplish. Clientele: The clientele who will utilize the technical document. This may include the people in the organization. This may also include "unintended readers." Customers: The population that may be affected by the content of the technical document generated. This includes the stakeholders who will be influenced. Environment: The background in which the document is created. Also, the nature of the situation that warranted the generation of the document. Swiss Psychologist Jean Piaget's view of Learning focuses on three aspects. The author likes to extend Jean Piaget's ideas to students, who are asked to prepare and submit Reader-Centered Technical Writing reports and exercises. Assimilation: Writers may benefit specifically, by assimilating a new object into

Laboratory Training Manual on the Use of Nuclear Techniques in Pesticide Research. Technical Reports Series No. 225.

ERIC Educational Resources Information Center

International Atomic Energy Agency, Vienna (Austria).

Radiolabelled pesticides are used: in studies involving improved formulations of pesticides, to assist in developing standard residue analytical methodology, and in obtaining metabolism data to support registration of pesticides. This manual is designed to give the scientist involved in pesticide research the basic terms and principles for…

Quality Manual

NASA Astrophysics Data System (ADS)

Koch, Michael

The quality manual is the “heart” of every management system related to quality. Quality assurance in analytical laboratories is most frequently linked with ISO/IEC 17025, which lists the standard requirements for a quality manual. In this chapter examples are used to demonstrate, how these requirements can be met. But, certainly, there are many other ways to do this.

Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells

PubMed Central

2013-01-01

Background In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTase) SETDB1/ESET and its binding partner KAP1/TRIM28. In contrast, the H3K9 KMTases G9a and GLP and HP1 proteins are dispensable for this process. Intriguingly, MERVL retroelements are actively transcribed exclusively in the two-cell (2C) embryo, but the molecular basis of silencing of these class III ERVs at later developmental stages has not been systematically addressed. Results Here, we characterized the roles of these chromatin factors in MERVL silencing in mESCs. While MMERVK10C and IAP ERVs are bound by SETDB1 and KAP1 and are induced following their deletion, MERVL ERVs show relatively low levels of SETDB1 and KAP1 binding and are upregulated exclusively following KAP1 depletion, indicating that KAP1 influences MERVL expression independent of SETDB1. In contrast to class I and class II ERVs, MERVL and MERVL LTR-driven genic transcripts are also upregulated following depletion of G9a or GLP, and G9a binds directly to these ERVs. Consistent with a direct role for H3K9me2 in MERVL repression, these elements are highly enriched for G9a-dependent H3K9me2, and catalytically active G9a is required for silencing of MERVL LTR-driven transcripts. MERVL is also derepressed in HP1α and HP1β KO ESCs. However, like KAP1, HP1α and HP1β are only modestly enriched at MERVL relative to IAP LTRs. Intriguingly, as recently shown for KAP1, RYBP, LSD1 and G9a-deficient mESCs, many genes normally expressed in the 2C embryo are also induced in HP1 KO mESCs, revealing that aberrant expression of a subset of 2C-specific genes is a common feature in each of these KO lines. Conclusions Our results indicate that G9a and GLP, which are not required for silencing of class I and II ERVs, are recruited to MERVL elements and play a direct role in silencing of these class

Covered bridge manual

DOT National Transportation Integrated Search

2005-04-01

This manual provides guidance to those involved with all aspects of the work, from initial inspection and evaluation, through the engineering of rehabilitation, to construction issues. Broadly speaking, this manual covers general terminology and hist...

A proposal for a test method for assessment of hazard property HP 12 ("Release of an acute toxic gas") in hazardous waste classification - Experience from 49 waste.

PubMed

Hennebert, Pierre; Samaali, Ismahen; Molina, Pauline

2016-12-01

A stepwise method for assessment of the HP 12 is proposed and tested with 49 waste samples. The hazard property HP 12 is defined as "Release of an acute toxic gas": waste which releases acute toxic gases (Acute Tox. 1, 2 or 3) in contact with water or an acid. When a waste contains a substance assigned to one of the following supplemental hazards EUH029, EUH031 and EUH032, it shall be classified as hazardous by HP 12 according to test methods or guidelines (EC, 2014a, 2014b). When the substances with the cited hazard statement codes react with water or an acid, they can release HCl, Cl 2 , HF, HCN, PH 3 , H 2 S, SO 2 (and two other gases very unlikely to be emitted, hydrazoic acid HN 3 and selenium oxide SeO 2 - a solid with low vapor pressure). Hence, a method is proposed:For a set of 49 waste, water addition did not produce gas. Nearly all the solid waste produced a gas in contact with hydrochloric acid in 5 min in an automated calcimeter with a volume >0.1L of gas per kg of waste. Since a plateau of pressure is reached only for half of the samples in 5 min, 6 h trial with calorimetric bombs or glass flasks were done and confirmed the results. Identification of the gases by portable probes showed that most of the tested samples emit mainly CO 2 . Toxic gases are emitted by four waste: metallic dust from the aluminum industry (CO), two air pollution control residue of industrial waste incinerator (H 2 S) and a halogenated solvent (organic volatile(s) compound(s)). HF has not been measured in these trials started before the present definition of HP 12. According to the definition of HP 12, only the H 2 S emission of substances with hazard statement EUH031 is accounted for. In view of the calcium content of the two air pollution control residue, the presence of calcium sulphide (EUH031) can be assumed. These two waste are therefore classified potentially hazardous for HP 12, from a total of 49 waste. They are also classified as hazardous for other properties (HP 7

Preparation, characterisation and antitumour activity of β-, γ- and HP-β-cyclodextrin inclusion complexes of oxaliplatin

NASA Astrophysics Data System (ADS)

Zhang, Da; Zhang, Jianqiang; Jiang, Kunming; Li, Ke; Cong, Yangwei; Pu, Shaoping; Jin, Yi; Lin, Jun

2016-01-01

Three water-soluble oxaliplatin complexes were prepared by inclusion complexation with β-cyclodextrin (β-CD), γ-CD and HP-β-CD. The structures of oxaliplatin/CDs were confirmed by NMR, FTIR, TGA, XRD as well as SEM analysis. The results show that the water solubility of oxaliplatin was increased in the complex with CDs in 1:1 stoichiometry inclusion modes, and the cyclohexane ring of oxaliplatin molecule was deeply inserted into the cavity of CDs. Moreover, the stoichiometry was established by a Job plot and the water stability constant (Kc) of oxaliplatin/CDs was calculated by phase solubility studies, all results show that the oxaliplatin/β-CD complex is more stable than free oxaliplatin, oxaliplatin/HP-β-CD and oxaliplatin/γ-CD. Meanwhile, the inclusion complexes displayed almost twice as high cytotoxicity compared to free oxaliplatin against HCT116 and MCF-7 cells. This satisfactory water solubility and higher cytotoxic activity of the oxaliplatin/CD complexes will potentially be useful for their application in anti-tumour therapy.

MARZ: Manual and automatic redshifting software

NASA Astrophysics Data System (ADS)

Hinton, S. R.; Davis, Tamara M.; Lidman, C.; Glazebrook, K.; Lewis, G. F.

2016-04-01

The Australian Dark Energy Survey (OzDES) is a 100-night spectroscopic survey underway on the Anglo-Australian Telescope using the fibre-fed 2-degree-field (2dF) spectrograph. We have developed a new redshifting application MARZ with greater usability, flexibility, and the capacity to analyse a wider range of object types than the RUNZ software package previously used for redshifting spectra from 2dF. MARZ is an open-source, client-based, Javascript web-application which provides an intuitive interface and powerful automatic matching capabilities on spectra generated from the AAOmega spectrograph to produce high quality spectroscopic redshift measurements. The software can be run interactively or via the command line, and is easily adaptable to other instruments and pipelines if conforming to the current FITS file standard is not possible. Behind the scenes, a modified version of the AUTOZ cross-correlation algorithm is used to match input spectra against a variety of stellar and galaxy templates, and automatic matching performance for OzDES spectra has increased from 54% (RUNZ) to 91% (MARZ). Spectra not matched correctly by the automatic algorithm can be easily redshifted manually by cycling automatic results, manual template comparison, or marking spectral features.

45 CFR 1182.15 - Institute responsibility for maintaining adequate technical, physical, and security safeguards to...

Code of Federal Regulations, 2010 CFR

2010-10-01

... record systems. These security safeguards shall apply to all systems in which identifiable personal data... data and automated systems shall be adequately trained in the security and privacy of personal data. (4... technical, physical, and security safeguards to prevent unauthorized disclosure or destruction of manual and...

TAE+ 5.2 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.2 (HP9000 SERIES 700/800 VERSION)

NASA Technical Reports Server (NTRS)

TAE SUPPORT OFFICE

1994-01-01

programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides a means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System and the Open Software Foundation's Motif. The HP 9000 Series 700/800 version of TAE 5.2 requires Version 11 Release 5 of the X Window System. All other machine versions of TAE 5.2 require Version 11, Release 4 of the X Window System. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus was developed in 1989 and version 5.2 was released in 1993. TAE Plus 5.2 is available on media suitable for five different machine platforms: (1) IBM RS/6000 series workstations running AIX (.25 inch tape cartridge in UNIX tar format), (2) DEC RISC

Influence of the β-Mg17Al12 Phase Morphology on the Corrosion Properties Of Az91hp Magnesium Alloy

NASA Astrophysics Data System (ADS)

Guo, Lingling; Zhang, Jumei

2017-09-01

The morphology of β-Mg17Al12 phase and corrosion behavior of AZ91HP magnesium alloy after spheroidizing treatment were investigated by optical microcope electrochemical and immersion tests in 3.5% NaCl at 25°C. The results show that the coarse divorced eutectic phase of AZ91HP cast magnesium alloy dissolve into Mg matrix during the isothermal process at 415°C, and the lameller β phase precipitated from magnesium solid solution as perlite-type precipitation during the slowly cooling. Next, the spheroidizing treatment at different temperatures for 20h was carried out, and the lameller β phase were spheroridizing by dissolved themselves. After spheroidizing treatment at 300°C for 20h, many small granular β phase are scattering within the magnesium matrix. The corrosion properties of AZ91HP magnesium alloy in 3.5% NaCl decreased obviously after spheroidizing treatment, the polarization measurement of the alloy can be up to -1.412V from -1.56V of the cast. The β-Mg17Al12 phase act as a corrosion barrier and hinder corrosion propagation, if the second phase is in the form of a spherical morphology.

SHARP User Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Y. Q.; Shemon, E. R.; Thomas, J. W.

SHARP is an advanced modeling and simulation toolkit for the analysis of nuclear reactors. It is comprised of several components including physical modeling tools, tools to integrate the physics codes for multi-physics analyses, and a set of tools to couple the codes within the MOAB framework. Physics modules currently include the neutronics code PROTEUS, the thermal-hydraulics code Nek5000, and the structural mechanics code Diablo. This manual focuses on performing multi-physics calculations with the SHARP ToolKit. Manuals for the three individual physics modules are available with the SHARP distribution to help the user to either carry out the primary multi-physics calculationmore » with basic knowledge or perform further advanced development with in-depth knowledge of these codes. This manual provides step-by-step instructions on employing SHARP, including how to download and install the code, how to build the drivers for a test case, how to perform a calculation and how to visualize the results. Since SHARP has some specific library and environment dependencies, it is highly recommended that the user read this manual prior to installing SHARP. Verification tests cases are included to check proper installation of each module. It is suggested that the new user should first follow the step-by-step instructions provided for a test problem in this manual to understand the basic procedure of using SHARP before using SHARP for his/her own analysis. Both reference output and scripts are provided along with the test cases in order to verify correct installation and execution of the SHARP package. At the end of this manual, detailed instructions are provided on how to create a new test case so that user can perform novel multi-physics calculations with SHARP. Frequently asked questions are listed at the end of this manual to help the user to troubleshoot issues.« less

Workplace Safety Manual

DOT National Transportation Integrated Search

2002-04-10

N.C. Department of Transportation's workplace safety manual for online viewing. : The government of North Carolina feels that all employees are responsible for safety : on the job. This manual describes and sets out the operation of safety program : ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wessol, D.E.; Wheeler, F.J.; Babcock, R.S.

Several improvements have been developed for the BNCT radiation treatment planning environment (BNCT-Rtpe) during 1994. These improvements have been incorporated into Version 1.0 of BNCT-Rtpe which is currently installed at the INEL, BNL, Japanese Research Center (JRC), and Finland`s Technical Research Center. Platforms supported by this software include Hewlett-Packard (HP), SUN, International Business Machines (IBM), and Silicon Graphics Incorporated (SGI). A draft version of the BNCT-Rtpe user manual is available. Version 1.1 of BNCT-Rtpe is scheduled for release in March 1995. It is anticipated that Version 2.x of BNCT-Rtpe, which includes the nonproprietary NURBS library and data structures, will bemore » released in September 1995.« less

44 CFR 18.205 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contract is allowable. However, communications with the intent to influence made by a professional (such as... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Professional and technical... Professional and technical services. (a) The prohibition on the use of appropriated funds, in § 18.100 (a...

Criterion-Referenced Measurement in the Army: Development of a Research- Based, Practical, Test Construction Manual

DTIC Science & Technology

1978-09-01

iE ARI TECHNICAL REPORT S~ TR-78-A31 M CCriterion-Reforencod Loasurement In the Army: Development of a Research-Based, Practical, Test Construction ...conducted to develop a Criterion- 1 Referenced Tests (CRTs) Construction Manual. Major accomplishments were the preparation of a written review of the...survey of the literature on Criterion-Referenced Testing’ conducted in order to provide an information base for development of the CRT Construction

Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer.

PubMed

Dowling, Paul; Clarke, Colin; Hennessy, Kim; Torralbo-Lopez, Beatriz; Ballot, Jo; Crown, John; Kiernan, Ingrid; O'Byrne, Kenneth J; Kennedy, M John; Lynch, Vincent; Clynes, Martin

2012-08-15

Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment in which specific biomarker panels are likely to be very important in each of these key areas. We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C3 (C3), clusterin (CLI), haptoglobin (HP) and serum amyloid A (SAA) are significantly altered in serum from patients with squamous cell carcinoma of the lung. Here, we report the abundance levels for these proteins in serum samples from patients with advanced breast cancer, colorectal cancer (CRC) and lung cancer compared to healthy controls (age and gender matched) using commercially available enzyme-linked immunosorbent assay kits. Logistic regression (LR) models were fitted to the resulting data, and the classification ability of the proteins was evaluated using receiver-operating characteristic curve and leave-one-out cross-validation (LOOCV). The most accurate individual candidate biomarkers were C3 for breast cancer [area under the curve (AUC) = 0.89, LOOCV = 73%], CLI for CRC (AUC = 0.98, LOOCV = 90%), HP for small cell lung carcinoma (AUC = 0.97, LOOCV = 88%), C3 for lung adenocarcinoma (AUC = 0.94, LOOCV = 89%) and HP for squamous cell carcinoma of the lung (AUC = 0.94, LOOCV = 87%). The best dual combination of biomarkers using LR analysis were found to be AHSG + C3 (AUC = 0.91, LOOCV = 83%) for breast cancer, CLI + HP (AUC = 0.98, LOOCV = 92%) for CRC, C3 + SAA (AUC = 0.97, LOOCV = 91%) for small cell lung carcinoma and HP + SAA for both adenocarcinoma (AUC = 0.98, LOOCV = 96%) and squamous cell carcinoma of the lung (AUC = 0.98, LOOCV = 84%). The high AUC values reported here indicated that these candidate biomarkers have the potential to discriminate accurately between control and cancer groups both individually and in combination with other proteins. Copyright © 2011 UICC.

The p- and h-p Versions of the Finite Element Method: An Overview

DTIC Science & Technology

1989-05-01

and h-p versions was studied in detail for 1 dimension in [48] and for 2 dimensions in [491. Let us mention some one dimensional results. We consider...Supercomputing in the Automotive Industry, Oct. 25-28 1988, Seville Spain, Report of Noetic Tech., St. Louis, NO 63117. 70. H. Vogelius, An analysis of the p...collaboration with govern- ment agencies such as the National Bureau of Standards. " To be an international center of study and research for foreign

The fast-folding HP35 double mutant has a substantially reduced primary folding free energy barrier

NASA Astrophysics Data System (ADS)

Lei, Hongxing; Deng, Xiaojian; Wang, Zhixiang; Duan, Yong

2008-10-01

The LYS24/29NLE double mutant of villin headpiece subdomain (HP35) is the fastest folding protein known so far with a folding time constant of 0.6μs. In this work, the folding mechanism of the mutant has been investigated by both conventional and replica exchange molecular dynamics (CMD and REMD) simulations with AMBER FF03 force field and a generalized-Born solvation model. Direct comparison to the ab initio folding of the wild type HP35 enabled a close examination on the mutational effect on the folding process. The mutant folded to the native state, as demonstrated by the 0.50Å Cα-root mean square deviation (RMSD) sampled in both CMD and REMD simulations and the high population of the folded conformation compared with the denatured conformations. Consistent with experiments, the significantly reduced primary folding free energy barrier makes the mutant closer to a downhill folder than the wild type HP35 that directly leads to the faster transition and higher melting temperature. However, unlike the proposed downhill folding which envisages a smooth shift between unfolded and folded states without transition barrier, we observed a well-defined folding transition that was consistent with experiments. Further examination of the secondary structures revealed that the two mutated residues have higher intrinsic helical preference that facilitated the formation of both helix III and the intermediate state which contains the folded segment helix II/III. Other factors contributing to the faster folding include the more favorable electrostatic interactions in the transition state with the removal of the charged NH3+ groups from LYS. In addition, both transition state ensemble and denatured state ensemble are shifted in the mutant.

Period Determination for 5049 Sherlock, 16852 Nuredduna and (16943) 1998 HP42

NASA Astrophysics Data System (ADS)

Marchini, Alessandro; Papini, Riccardo; Salvaggio, Fabio

2018-04-01

Photometric observations of three main-belt asteroids were conducted from the Astronomical Observatory of the University of Siena (Italy) in order to determine their synodic rotation periods. For 5049 Sherlock we found a period of 5.492 ± 0.001 h with an amplitude of 0.79 mag, for 16852 Nuredduna a period of 6.299 ± 0.002 h with an amplitude of 0.30 mag and for (16943) 1998 HP42 a period of 16.764 ± 0.006 h with an amplitude of 0.67 mag.

Reflections on Three Corporate Research Labs: Bell Labs, HP Labs, Agilent Labs

NASA Astrophysics Data System (ADS)

Hollenhorst, James

2008-03-01

This will be a personal reflection on corporate life and physics-based research in three industrial research labs over three decades, Bell Labs during the 1980's, HP Labs during the 1990's, and Agilent Labs during the 2000's. These were times of great change in all three companies. I'll point out some of the similarities and differences in corporate cultures and how this impacted the research and development activities. Along the way I'll mention some of the great products that resulted from physics-based R&D.

Healthy Water Healthy People Field Monitoring Guide

ERIC Educational Resources Information Center

Project WET Foundation, 2003

2003-01-01

This 100-page manual serves as a technical reference for the "Healthy Water, Healthy People Water Quality Educators Guide" and the "Healthy Water Healthy People Testing Kits". Yielding in-depth information about ten water quality parameters, it answers questions about water quality testing using technical overviews, data interpretation guidelines,…

Evaluation of manual and automatic manually triggered ventilation performance and ergonomics using a simulation model.

PubMed

Marjanovic, Nicolas; Le Floch, Soizig; Jaffrelot, Morgan; L'Her, Erwan

2014-05-01

In the absence of endotracheal intubation, the manual bag-valve-mask (BVM) is the most frequently used ventilation technique during resuscitation. The efficiency of other devices has been poorly studied. The bench-test study described here was designed to evaluate the effectiveness of an automatic, manually triggered system, and to compare it with manual BVM ventilation. A respiratory system bench model was assembled using a lung simulator connected to a manikin to simulate a patient with unprotected airways. Fifty health-care providers from different professional groups (emergency physicians, residents, advanced paramedics, nurses, and paramedics; n = 10 per group) evaluated manual BVM ventilation, and compared it with an automatic manually triggered device (EasyCPR). Three pathological situations were simulated (restrictive, obstructive, normal). Standard ventilation parameters were recorded; the ergonomics of the system were assessed by the health-care professionals using a standard numerical scale once the recordings were completed. The tidal volume fell within the standard range (400-600 mL) for 25.6% of breaths (0.6-45 breaths) using manual BVM ventilation, and for 28.6% of breaths (0.3-80 breaths) using the automatic manually triggered device (EasyCPR) (P < .0002). Peak inspiratory airway pressure was lower using the automatic manually triggered device (EasyCPR) (10.6 ± 5 vs 15.9 ± 10 cm H2O, P < .001). The ventilation rate fell consistently within the guidelines, in the case of the automatic manually triggered device (EasyCPR) only (10.3 ± 2 vs 17.6 ± 6, P < .001). Significant pulmonary overdistention was observed when using the manual BVM device during the normal and obstructive sequences. The nurses and paramedics considered the ergonomics of the automatic manually triggered device (EasyCPR) to be better than those of the manual device. The use of an automatic manually triggered device may improve ventilation efficiency and decrease the risk of

45 CFR 1159.15 - Who has the responsibility for maintaining adequate technical, physical, and security safeguards...

Code of Federal Regulations, 2010 CFR

2010-10-01

... disclosure or destruction of manual and automatic record systems. These security safeguards shall apply to... use of records contained in a system of records are adequately trained to protect the security and... adequate technical, physical, and security safeguards to prevent unauthorized disclosure or destruction of...

Writing the Trenches: What Students of Technical Writing and Literature Can Learn Together

ERIC Educational Resources Information Center

Baake, Ken; Shelton, Jen

2017-01-01

We argue for a course in which students analyze writing about a common topic--in this case World War I--from multiple genres (e.g., poetry and technical manuals). We address the divide between instruction in pragmatic and literary writing and calls to bridge that gap. Students working in disparate areas of English learn the strengths and the…

Mua (HP0868) is a nickel-binding protein that modulates urease activity in Helicobacter pylori.

PubMed

Benoit, Stéphane L; Maier, Robert J

2011-01-01

A novel mechanism aimed at controlling urease expression in Helicobacter pylori in the presence of ample nickel is described. Higher urease activities were observed in an hp0868 mutant (than in the wild type) in cells supplemented with nickel, suggesting that the HP0868 protein (herein named Mua for modulator of urease activity) represses urease activity when nickel concentrations are ample. The increase in urease activity in the Δmua mutant was linked to an increase in urease transcription and synthesis, as shown by quantitative real-time PCR, SDS-PAGE, and immunoblotting against UreAB. Increased urease synthesis was also detected in a Δmua ΔnikR double mutant strain. The Δmua mutant was more sensitive to nickel toxicity but more resistant to acid challenge than was the wild-type strain. Pure Mua protein binds 2 moles of Ni(2+) per mole of dimer. Electrophoretic mobility shift assays did not reveal any binding of Mua to the ureA promoter or other selected promoters (nikR, arsRS, 5' ureB-sRNAp). Previous yeast two-hybrid studies indicated that Mua and RpoD may interact; however, only a weak interaction was detected via cross-linking with pure components and this could not be verified by another approach. There was no significant difference in the intracellular nickel level between wild-type and mua mutant cells. Taken together, our results suggest the HP0868 gene product represses urease transcription when nickel levels are high through an as-yet-uncharacterized mechanism, thus counterbalancing the well-described NikR-mediated activation. Urease is a nickel-containing enzyme that buffers both the cytoplasm and the periplasm of Helicobacter pylori by converting urea into ammonia and carbon dioxide. The enzyme is the most abundant protein in H. pylori, accounting for an estimated 10% of the total protein content of the cell, and it is essential for early colonization and virulence. Numerous studies have focused on the transcription of the structural ureAB genes

Clinical efficacy and cost-effectiveness of HP-human FSH (Fostimon®) versus rFSH (Gonal-F®) in IVF-ICSI cycles: a meta-analysis.

PubMed

Gerli, Sandro; Bini, Vittorio; Favilli, Alessandro; Di Renzo, Gian Carlo

2013-06-01

Clinical efficacy of human-derived follicle-stimulating hormone (FSH) versus recombinant FSH (rFSH) in IVF-ICSI cycles has long been compared, but no clear evidence of the superiority of a preparation over the other has been found. Human gonadotropins have been often grouped together, but a different glycosylation may be present in each preparation, therefore influencing the specific bioactivity. To exclude confounding factors, a meta-analysis and a cost-effectiveness analysis were designed to compare effectiveness and cost-effectiveness of a specific highly purified human FSH (HP-hFSH) (Fostimon®) versus rFSH (Gonal-F®) in IVF/ICSI cycles. Research methodology filters were applied in MEDLINE, Current Contents and Web of Science from 1980 to February 2012. Eight randomized trials met selection criteria. The meta-analysis showed no significant differences between rFSH and HP-hFSH treatment in live-birth rate (odds ratio [OR] 0.84, 95% confidence interval [CI] 0.63-1.11), clinical pregnancy rate (OR 0.85, 95% CI 0.68-1.07), number of oocytes retrieved, number of mature oocytes and days of stimulation. The cost-effectiveness ratio was € 7174 in the rFSH group and € 2056 in the HP-hFSH group. HP-hFSH is as effective as rFSH in ovarian stimulation for IVF-ICSI cycles, but the human preparation is more cost-effective.

A Closer Look at Visual Manuals.

ERIC Educational Resources Information Center

van der Meij, Hans

1996-01-01

Examines the visual manual genre, discussing main forms and functions of step-by-step and guided tour manuals in detail. Examines whether a visual manual helps computer users realize tasks faster and more accurately than a non-visual manual. Finds no effects on accuracy, but speedier task execution by 35% for visual manuals. Concludes there is no…

Comparative study of 2 electric and 2 manual toothbrushes in patients with fixed orthodontic appliances.

PubMed

Thienpont, V; Dermaut, L R; Van Maele, G

2001-10-01

The objective of this prospective single-blind crossover clinical trial was to evaluate the efficacy of 4 toothbrushes in 33 children undergoing fixed appliance orthodontic therapy. The toothbrushes included in this study were the Braun Oral-B 3D Plaque Remover (Kronberg, Germany), the Philips-Jordan HP 510 (Philips Domestic Appliances, Groningen, The Netherlands), the Lactona orthodontic toothbrush (Bergen op Zoom, The Netherlands), and the Oral-B Advantage Control Grip (Braun); the first 2 are electric, and the last 2 are manual. Every patient tested each type of toothbrush in a randomly designed sequence. Plaque and gingival scores were recorded at baseline and after every 4-week test period. All patients received professional prophylaxis after each clinical evaluation. The data were analyzed with the Friedman test, which showed no significant differences among the 4 brushes for any of the parameters measured. The Wilcoxon signed rank test, comparing the plaque and the gingival scores between the upper and lower jaw for each brush, indicated that plaque removal was more efficient in the lower jaw than in the upper.

Product Manuals: A Consumer Perspective.

ERIC Educational Resources Information Center

Showers, Linda S.; And Others

1993-01-01

Qualitative analysis of insights from consumer focus groups on product manual usage reveals consumer perceptions and preferences regarding manual and safety message format. Results can be used to improve manual design and content. (JOW)

The effect of experience, simulator-training and biometric feedback on manual ventilation technique.

PubMed

Lewis, Rebecca; Sherfield, Cerrie A; Fellows, Christopher R; Burrow, Rachel; Young, Iain; Dugdale, Alex

2017-05-01

To determine the frequency of provision and main providers (veterinary surgeons, nurses or trainees) of manual ventilation in UK veterinary practices. Furthermore, to determine the variation in peak inspiratory (inflation) pressure (PIP), applied to a lung model during manual ventilation, by three different groups of operators (inexperienced, experienced and specialist), before and after training. Questionnaire survey, lung model simulator development and prospective testing. Postal questionnaires were sent to 100 randomly selected veterinary practices. The lung model simulator was manually ventilated in a staged process over 3 weeks, with and without real-time biometric feedback (PIP display), by three groups of volunteer operators: inexperienced, experienced and specialist. The questionnaires determined that veterinary nurses were responsible for providing the majority of manual ventilation in veterinary practices, mainly drawing on theoretical knowledge rather than any specific training. Thoracic surgery and apnoea were the main reasons for provision of manual ventilation. Specialists performed well when manually ventilating the lung model, regardless of feedback training. Both inexperienced and experienced operators showed significant improvement in technique when using the feedback training tool: variation in PIP decreased significantly until operators provided manual ventilation at PIPs within the defined optimum range. Preferences for different forms of feedback (graphical, numerical or scale display), revealed that the operators' choice was not always the method which gave least variation in PIP. This study highlighted a need for training in manual ventilation at an early stage in veterinary and veterinary nursing careers and demonstrated how feedback is important in the process of experiential learning. A manometer device which can provide immediate feedback during training, or indeed in a real clinical setting, should improve patient safety. Copyright

75 FR 38394 - Airworthiness Directives; The Boeing Company Model 747-100, -200B, and -200F Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-02

... Airworthiness Directives; The Boeing Company Model 747-100, - 200B, and -200F Series Airplanes AGENCY: Federal... inconsistent with the terminology used in the structural repair manual and Boeing Alert Service Bulletin 747... The Boeing Company Model 747-100, 747- 200B, and 747-200F series airplanes, certificated in any...

Nurse Assistant in Acute, Home Health and Long-Term Care Settings. Instructor Manual [and] Student Manual.

ERIC Educational Resources Information Center

Winberg, Pat

This document consists of an instructor's manual and student manual for a nurse assistant curriculum. The instructor's manual provides answers to activity sheets and unit evaluations along with individual unit overviews. Suggested teaching strategies and audiovisual supplements are included for each lesson. The student manual contains eight units:…

The Combination Process for Preparative Separation and Purification of Paclitaxel and 10-Deacetylbaccatin III Using Diaion® Hp-20 Followed by Hydrophilic Interaction Based Solid Phase Extraction.

PubMed

Shirshekanb, Mahsa; Rezadoost, Hassan; Javanbakht, Mehran; Ghassempour, Ali Reza

2017-01-01

There is no other naturally occurring defense agent against cancer that has a stronger effect than paclitaxel, commonly known under the brand name of Taxol ® . The major drawback for the more widespread use of paclitaxel and its precious precursor, 10-deacetylbaccatin III (10-DAB III), is that they require large-scale extraction from different parts of yew trees ( Taxus species), cell cultures, taxane-producing endophytic fungi, and Corylus species. In our previous work, a novel online two-dimensional heart-cut liquid chromatography process using hydrophilic interaction/ reversed-phase chromatography was used to introduce a semi-preparative treatment for the separation of polar (10-deacetylbaccatin III) and non-polar (paclitaxel) taxanes from Taxus baccata L. In this work, a combination of the absorbent (Diaion ®  HP-20) and a silica based solid phase extraction is utilized as a new, efficient, and cost effective method for large-scale production of taxanes. This process avoids the technical problem of two-dimensional preparative liquid chromatography. The first stage of the process involves discarding co-extractive polar compounds including chlorophylls and pigments using a non-polar synthetic hydrophobic absorbent, Diaion ®  HP-20. Extract was then loaded on to a silica based hydrophilic interaction solid phase extraction (silica 40-60 micron). Taxanes was eluted using a mixture of water and methanol at the optimized ratio of 70:30. Finally, the fraction containing taxanes was applied to semi-preparative reversed phase HPLC. The results revealed that using this procedure, paclitaxel and 10-DAB III could be obtained at 8 and 3 times more, respectively than by the traditional method of extraction.

Tip-alpha (hp0596 gene product) is a highly immunogenic Helicobacter pylori protein involved in colonization of mouse gastric mucosa.

PubMed

Godlewska, Renata; Pawlowski, Marcin; Dzwonek, Artur; Mikula, Michal; Ostrowski, Jerzy; Drela, Nadzieja; Jagusztyn-Krynicka, Elzbieta K

2008-03-01

A product of the Helicobacter pylori hp0596 gene (Tip-alpha) is a highly immunogenic homodimeric protein, unique for this bacterium. Cell fractionation experiments indicate that Tip-alpha is anchored to the inner membrane. In contrast, the three-dimensional model of the protein suggests that Tip-alpha is soluble or, at least, largely exposed to the solvent. hp0596 gene knockout resulted in a significant decrease in the level of H. pylori colonization as measured by real-time PCR assay. In addition, the Tip-alpha recombinant protein was determined to stimulate macrophage to produce IL-1alpha and TNF-alpha. Both results imply that Tip-alpha is rather loosely connected to the inner membrane and potentially released during infection.

Comparative evaluation of electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) and high-pH reversed phase (Hp-RP) chromatography in profiling of rat kidney proteome.

PubMed

Hao, Piliang; Ren, Yan; Dutta, Bamaprasad; Sze, Siu Kwan

2013-04-26

ERLIC and high-pH RP (Hp-RP) have been reported to be promising alternatives to strong cation exchange (SCX) in proteome fractionation. Here we compared the performance of ERLIC, concatenated ERLIC and concatenated Hp-RP in proteome profiling. The protein identification is comparable in these three strategies, but significantly more unique peptides are identified by the two concatenation methods, resulting in a significant increase of the average protein sequence coverage. The pooling of fractions from spaced intervals results in more uniform distribution of peptides in each fraction compared with the chromatogram-based pooling of adjacent fractions. ERLIC fractionates peptides according to their pI and GRAVY values. These properties remains but becomes less remarkable in concatenated ERLIC. In contrast, the average pI and GRAVY values of the peptides are comparable in each fraction in concatenated Hp-RP. ERLIC performs the best in identifying peptides with pI>9 among the three strategies, while concatenated Hp-RP is good at identifying peptides with pI<4. These advantages are useful when either basic or acidic peptides/proteins are analytical targets. The power of ERLIC in identification of basic peptides seems to be due to their efficient separation from acidic peptides. This study facilitates the choice of proper fractionation strategies based on specific objectives. For in-depth proteomic analysis of a cell, tissue and plasma, multidimensional liquid chromatography (MDLC) is still necessary to reduce sample complexity for improving analytical dynamic range and proteome coverage. This work conducts a direct comparison of three promising first-dimensional proteome fractionation methods. They are comparable in identifying proteins, but concatenated ERLIC and concatenated Hp-RP identify significantly more unique peptides than ERLIC. ERLIC is good at analyzing basic peptides, while concatenated Hp-RP performs the best in analyzing acidic peptides with pI<4. This

Using 100G Network Technology in Support of Petascale Science

NASA Technical Reports Server (NTRS)

Gary, James P.

2011-01-01

NASA in collaboration with a number of partners conducted a set of individual experiments and demonstrations during SC 10 that collectively were titled "Using 100G Network Technology in Support of Petascale Science". The partners included the iCAIR, Internet2, LAC, MAX, National LambdaRail (NLR), NOAA and SCinet Research Sandbox (SRS) as well as the vendors Ciena, Cisco, ColorChip, cPacket, Extreme Networks, Fusion-io, HP and Panduit who most generously allowed some of their leading edge 40G/100G optical transport, Ethernet switch and Internet Protocol router equipment and file server technologies to be involved. The experiments and demonstrations featured different vendor-provided 40G/100G network technology solutions for full-duplex 40G and 100G LAN data flows across SRS-deployed single-node fiber-pairs among the Exhibit Booths of NASA, the National Center for Data lining, NOAA and the SCinet Network Operations Center, as well as between the NASA Exhibit Booth in New Orleans and the Starlight Communications Exchange facility in Chicago across special SC 10- only 80- and 100-Gbps wide area network links provisioned respectively by the NLR and Internet2, then on to GSFC across a 40-Gbps link. provisioned by the Mid-Atlantic Crossroads. The networks and vendor equipment were load-stressed by sets of NASA/GSFC High End Computer Network Team-built, relatively inexpensive, net-test-workstations that are capable of demonstrating greater than 100Gbps uni-directional nuttcp-enabled memory-to-memory data transfers, greater than 80-Gbps aggregate--bidirectional memory-to-memory data transfers, and near 40-Gbps uni-directional disk-to-disk file copying. This paper will summarize the background context, key accomplishments and some significances of these experiments and demonstrations.

Support for Astronaut's View of Mexican/ Central American Fires and on-Line Earth Observations Training Manual

NASA Technical Reports Server (NTRS)

Kaminski, Charles F., Jr.

1999-01-01

A small project to compile remote sensing and in-site data to review the processes leading to the May 1998 Mexican/Central American fires was undertaken. A web page based on this project was assembled. The second project initiated involved an interactive and on-line program that will replace the paper version of the Earth Observations Preflight Training Manual. Technical support was provided to Prof. Marvin Glasser as needed.

In-Home Respite Care Program Development. Background. Coordinator's Manual. Training Manual.

ERIC Educational Resources Information Center

Parham, J. D.; And Others

This volume consists of a background discussion, coordinator's manual, and training manual dealing with developing programs for the in-home respite care (IHRC) of the developmentally disabled. Addressed in the background information unit are the nature of developmental disabilities; program variables, planning, and funding; and practical…

Technical/commercial feasibility study of the production of fuel-grade ethanol from corn: 100-million-gallon-per-year production facility in Myrtle Grove, Louisiana

NASA Astrophysics Data System (ADS)

1982-05-01

The technical and economic feasibility of producing motor fuel alcohol from corn in a 100 million gallon per year plant to be constructed in Myrtle Grove, Louisiana is evaluated. The evaluation includes a detailed process design using proven technology, a capital cost estimate for the plant, a detailed analysis of the annual operating cost, a market study, a socioeconomic, environmental, health and safety analysis, and a complete financial analysis. Several other considerations for production of ethanol were evaluated including: cogeneration and fuel to be used in firing the boilers; single by-products vs. multiple by-products; and use of boiler flue gas for by-product drying.

Carpentry: Apprentice Related Training. Instructor's Manual. First, Second, Third, Fourth Years of a Four-Year Series in Four Volumes.

ERIC Educational Resources Information Center

Washington State Coordinating Council for Occupational Education, Olympia.

The course of related study in the carpentry trade is designed to meet the need for organized study in the various technical aspects necessary for an apprentice to become a well-trained journeyman. Divided into four one-year programs, the instructor's manual for the first year presents lessons on familiarizing the student with the trade and its…

An Evaluation of the Work and Life Conditions and the Quality of Life in 60 to 65 Year-Old White-Collar Employees, Manual Workers, and Unemployed Controls.

PubMed

Sołtysik, Bartłomiej K; Kroc, Łukasz; Pigłowska, Małgorzata; Guligowska, Agnieszka; Śmigielski, Janusz; Kostka, Tomasz

2017-05-01

Assessment of the work and life conditions of 60 to 65-year-old seniors with regard to type of work and quality of life (QoL). The European Foundation for Improvement of Living and Working Conditions Questionnaire and the EuroQol 5D were used to evaluate work and life conditions and QoL in the three age- and sex-matched 60 to 65-year-old groups (white-collar, manual workers, and unemployed subjects, 100 each group, 50% of women). Manual workers and unemployed subjects had lower QoL score (0 to 100 point scale) than white-collar workers (accordingly 72.2; 71.2; 76.2; P < 0.05). In working subjects (n = 200), QoL was inversely associated with reported health problems (P < 0.01) and directly related to quality of work (P < 0.001). In the group of manual workers (n = 100), QoL indices were influenced by health factors and quality of work, while in the intellectual group (n = 100) mainly by health factors. Quality of work and health assessment are the main domains that influence older workers' QoL and may contribute to the shortening of the work period and accelerated transfer to retirement. Quality of work assessment seems especially important in older manual workers.

Method of Characteristic (MOC) Nozzle Flowfield Solver - User’s Guide and Input Manual Version 2.0

DTIC Science & Technology

2018-01-01

TECHNICAL REPORT RDMR-SS-17-13 METHOD OF CHARACTERISTIC (MOC) NOZZLE FLOWFIELD SOLVER—USER’S GUIDE AND INPUT MANUAL VERSION 2.0 Kevin D. Kennedy...System Simulation and Development Directorate Aviation and Missile Research , Development, and Engineering Center January 2018 Distribution Statement...DOCUMENTS, DESTROY BY ANY METHOD THAT WILL PREVENT DISCLOSURE OF CONTENTS OR RECONSTRUCTION OF THE DOCUMENT. DISCLAIMER THE FINDINGS IN THIS REPORT