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1

Emulsion Chamber Technology Experiment (ECT)  

NASA Technical Reports Server (NTRS)

The experimental objective of Emulsion Chamber Technology (ECT) was to develop space-borne emulsion chamber technology so that cosmic rays and nuclear interactions may subsequently be studied at extremely high energies with long exposures in space. A small emulsion chamber was built and flown on flight STS-62 of the Columbia in March 1994. Analysis of the several hundred layers of radiation-sensitive material has shown excellent post-flight condition and suitability for cosmic ray physics analysis at much longer exposures. Temperature control of the stack was 20 +/-1 C throughout the active control period and no significant deviations of temperature or pressure in the chamber were observed over the entire mission operations period. The unfortunate flight attitude of the orbiter (almost 90% Earth viewing) prevented any significant number of heavy particles (Z greater than or equal to 10) reaching the stack and the inverted flow of shower particles in the calorimeter has not allowed evaluation of absolute primary cosmic ray-detection efficiency nor of the practical time limits of useful exposure of these calorimeters in space to the level of detail originally planned. Nevertheless, analysis of the observed backgrounds and quality of the processed photographic and plastic materials after the flight show that productive exposures of emulsion chambers are feasible in low orbit for periods of up to one year or longer. The engineering approaches taken in the ECT program were proven effective and no major environmental obstacles to prolonged flight are evident.

Gregory, John C.; Takahashi, Yoshiyuki

1996-01-01

2

Emerging Communication Technologies (ECT) Phase 4 Report  

NASA Technical Reports Server (NTRS)

The Emerging Communication Technology (ECT) project investigated three First Mile communication technologies in support of NASA s Crew Exploration Vehicle (CEV), Advanced Range Technology Working Group (ARTWG), and the Advanced Spaceport Technology Working Group (ASTWG). These First Mile technologies have the purpose of interconnecting mobile users with existing Range Communication infrastructures on a 24/7 basis. ECT is a continuation of the Range Information System Management (RISM) task started in 2002. This is the fourth year of the project.

Bastin, Gary L.; Harris, William G.; Marin, Jose A.; Nelson, Richard A.

2005-01-01

3

Emerging Communication Technologies (ECT) Phase 2 Report. Volume 2; Appendices  

NASA Technical Reports Server (NTRS)

The Emerging Communication Technology (ECT) project investigated three First Mile communication technologies in support of NASA s Second Generation Reusable Launch Vehicle (2nd Gen RLV), Orbital Space Plane, Advanced Range Technology Working Group (ARTWG) and the Advanced Spaceport Technology Working Group (ASTWG). These First Mile technologies have the purpose of interconnecting mobile users with existing Range Communication infrastructures. ECT was a continuation of the Range Information System Management (RISM) task started in 2002. RISM identified the three advance communication technologies investigated under ECT. These were Wireless Ethernet (Wi-Fi), Free Space Optics (FSO), and Ultra Wideband (UWB). Due to the report s size, it has been broken into three volumes: 1) Main Report 2) Appendices 3) UWB

Bastin, Gary L.; Harris, William G.; Chiodini, Robert; Nelson, Richard A.; Huang, PoTien; Kruhm, David A.

2003-01-01

4

Emerging Communication Technologies (ECT) Phase 3 Final Report  

NASA Technical Reports Server (NTRS)

The Emerging Communication Technology (ECT) project investigated three First Mile communication technologies in support of NASA s Second Generation Reusable Launch Vehicle (2nd Gen RLV), Orbital Space Plane, Advanced Range Technology Working Group (ARTWG) and the Advanced Spaceport Technology Working Group (ASTWG). These First Mile technologies have the purpose of interconnecting mobile users with existing Range Communication infrastructures. ECT was a continuation of the Range Information System Management (RISM) task started in 2002. RISM identified the three advance communication technologies investigated under ECT. These were Wireless Ethernet (Wi-Fi), Free Space Optics (FSO), and Ultra Wideband (UWB). Due to the report s size, it has been broken into three volumes: 1) Main Report 2) Appendices 3) UWB.

Bastin, Gary L.; Harris, William G.; Bates, Lakesha D.; Nelson, Richard A.

2004-01-01

5

Emerging Communication Technologies (ECT) Phase 2 Report. Volume 3; Ultra Wideband (UWB) Technology  

NASA Technical Reports Server (NTRS)

The Emerging Communication Technology (ECT) project investigated three First Mile communication technologies in support of NASA s Second Generation Reusable Launch Vehicle (2nd Gen RLV), Orbital Space Plane, Advanced Range Technology Working Group (ARTWG) and the Advanced Spaceport Technology Working Group (ASTWG). These First Mile technologies have the purpose of interconnecting mobile users with existing Range Communication infrastructures. ECT was a continuation of the Range Information System Management (RISM) task started in 2002. RISM identified the three advance communication technologies investigated under ECT. These were Wireless Ethernet (Wi-Fi), Free Space Optics (FSO), and Ultra Wideband (UWB). Due to the report s size, it has been broken into three volumes: 1) Main Report 2) Appendices 3) UWB

Bastin, Gary L.; Harris, William G.; Chiodini, Robert; Nelson, Richard A.; Huang, PoTien; Kruhm, David A.

2003-01-01

6

Emerging Communication Technologies (ECT) Phase 2 Report. Volume 1; Main Report  

NASA Technical Reports Server (NTRS)

The Emerging Communication Technology (ECT) project investigated three First Mile communication technologies in support of NASA s Second Generation Reusable Launch Vehicle (2nd Gen RLV), Orbital Space Plane, Advanced Range Technology Working Group (ARTWG) and the Advanced Spaceport Technology Working Group (ASTWG). These First Mile technologies have the purpose of interconnecting mobile users with existing Range Communication infrastructures. ECT was a continuation of the Range Information System Management (RISM) task started in 2002. RISM identified the three advance communication technologies investigated under ECT. These were Wireless Ethernet (Wi-Fi), Free Space Optics (FSO), and Ultra Wideband (UWB). Due to the report s size, it has been broken into three volumes: 1) Main Report 2) Appendices 3) UWB.

Bastin, Gary L.; Harris, William G.; Chiodini, Robert; Nelson, Richard A.; Huang, PoTien; Kruhm, David A.

2003-01-01

7

TOPICAL REVIEW: Microsystem technologies for implantable applications  

NASA Astrophysics Data System (ADS)

Microsystem technologies (MST) have become the basis of a large industry. The advantages of MST compared to other technologies provide opportunities for application in implantable biomedical devices. This paper presents a general and broad literature review of MST for implantable applications focused on the technical domain. A classification scheme is introduced to order the examples, basic technological building blocks relevant for implantable applications are described and finally a case study on the role of microsystems for one clinical condition is presented. We observe that the microfabricated parts span a wide range for implantable applications in various clinical areas. There are 94 active and 67 commercial 'end items' out of a total of 142. End item refers to the total concept, of which the microsystem may only be a part. From the 105 active end items 18 (13% of total number of end items) are classified as products. From these 18 products, there are only two for chronic use. The number of active end items in clinical, animal and proto phase for chronic use is 17, 13 and 20, respectively. The average year of first publication of chronic end items that are still in the animal or clinical phase is 1994 (n = 7) and 1993 (n = 11), respectively. The major technology market combinations are sensors for cardiovascular, drug delivery for drug delivery and electrodes for neurology and ophthalmology. Together these form 51% of all end items. Pressure sensors form the majority of sensors and there is just one product (considered to be an implantable microsystem) in the neurological area. Micro-machined ceramic packages, glass sealed packages and polymer encapsulations are used. Glass to metal seals are used for feedthroughs. Interconnection techniques such as flip chip, wirebonding or conductive epoxy as used in the semiconductor packaging and assembly industry are also used for manufacturing of implantable devices. Coatings are polymers or metal. As an alternative to implantable primary batteries, rechargeable batteries were introduced or concepts in which energy is provided from the outside based on inductive coupling. Long-term developments aiming at autonomous power are, for example, based on electrostatic conversion of mechanical vibrations. Communication with the implantable device is usually done using an inductive link. A large range of materials commonly used in microfabrication are also used for implantable microsystems.

Receveur, Rogier A. M.; Lindemans, Fred W.; de Rooij, Nicolaas F.

2007-05-01

8

WHAT IS ECT? DOES ECT WORK?  

E-print Network

of patients. What are the risks and benefits? ECT treatment has been associated with short-term memory loss with the consequences of ineffectively treated severe psychiatric disorders. For some patients, the risks of ECT may? WHAT ARE THE RISKS AND BENEFITS? RESOURCES Electroconvulsive Therapy (ECT) Although ECT can be very

Oliver, Douglas L.

9

Implanted : technology and connection in the deaf world  

E-print Network

In 1984, the FDA approved a medical device called a cochlear implant for adult use in the United States. Unlike assistive hearing technologies that came before it, such as hearing aids, cochlear implants could offer wider ...

Calamia, Joseph Benjamin

2010-01-01

10

The Economic E?ects of Technological Progress: Evidence from the Banking Industry  

Microsoft Academic Search

Abstract This paper examines technological progress and its effects in the banking industry. Banks are intensive users of both IT and financial technologies, and have a wealth of data available that may be helpful for the general understanding of the effects of technological change. The research suggests improvements,in costs and lending capacity due to improvements in “back-office” technologies, as well

A. N. Berger

2003-01-01

11

Implantable Micropump Technologies for Murine Intracochlear Infusions  

PubMed Central

Due to the very small size of the mouse inner ear, 600 nL volume, developing effective, controlled infusion systems is quite challenging. Key technologies have been created to minimize both size and power for an implantable pump for murine intracochlear infusions. A method for coupling fine capillary tubing to microfluidic channels is presented which provides low volume, biocompatible interconnects withstanding pressures as high as 827 kPa (120 psi) and consuming less than 20 nL of volume exiting in-plane with the pump. Surface micromachined resistive bridges integrated into the flow channel for anemometry based flow rate measurement have been optimized for low power operation in the ultra-low flow rate regime. A process for creation of deformable diaphragms over pump chambers with simultaneous coating of the microfluidic channels has been developed allowing integration of a biocompatible fluid flow path. These advances represent enabling capabilities for a drug delivery system suitable for space constrained applications such as subcutaneous implantation in mice. PMID:21096713

Johnson, D. G.; Waldron, M. J.; Frisina, R. D.; Borkholder, D. A.

2011-01-01

12

Evaluating the Feasibility of Using Remote Technology for Cochlear Implants  

ERIC Educational Resources Information Center

The use of remote technology to provide cochlear implant services has gained popularity in recent years. This article contains a review of research evaluating the feasibility of remote service delivery for recipients of cochlear implants. To date, published studies have determined that speech-processor programming levels and other objective tests…

Goehring, Jenny L.; Hughes, Michelle L.; Baudhuin, Jacquelyn L.

2012-01-01

13

Innovation and regulation in human implant technologies: developing comparative approaches.  

PubMed

Human implant technologies are subject to continual innovation and proliferation, raising important issues for technology testing, healthcare sciences, clinical performance and risk assessment, and regulation. The regulatory environment of medical devices is being shaped by harmonisation of standards in the European Union. The aim of this paper is to compare the histories and current regulatory environment of two technologies, breast implants and artificial hips, and to consider the implications of this comparison for a sociological healthcare research agenda to investigate the issues raised. The main focus is upon developments in the United Kingdom. Major points of contrast between the two technologies include the institutional contexts in which clinical evidence has been marshalled for government attention; the relative importance of strategic alliances between clinicians and manufacturers in the innovation process; the degree of public controversy evident; the varying definitions of an 'adverse incident' within medical device vigilance systems; and in the UK the presence of a national register for breast implants but not for hip implants. Inter-national contrasts in these dimensions are noted. The analysis suggests that improved understanding is required of the institutional, organisational and professional processes involved in implant technology innovation and regulation. A comparative research agenda is proposed, focusing upon: innovativeness and proliferation; safety and technological standards; clinical and social outcomes; and consumer/user information and choice. It is concluded that research in these areas will enhance the 'evidence-base' for the evaluation of human implant technologies in the context of their innovatory and regulatory environments. PMID:11522136

Faulkner, A; Kent, J

2001-10-01

14

A simplified approach to implant restorations using innovative digital technology.  

PubMed

Digital impressions and CAM/CAD systems are currently burgeoning dental technologies. This article presents a case study describing the clinical protocol necessary to produce multiple crown restorations supported by dental implants. PMID:25842466

Brooks, Jeffery H; Wicks, Russell A; Hottel, Timothy L

2014-01-01

15

ECT IN NEUROLOGICAL COUNDITIONS  

PubMed Central

It is a myth that electroconvulsive therapy (ECT) produces greater side effects and worsens the neurological condition when used in neurologically ill patients. With the advancement and sophistication in ECT practice standards and modification procedures, it can be safely administered either to treat selected neurological conditions or the co-morbid psychiatric illnesses without additional risks. However ECT should be administered only after thorough evaluation of risks and benefits in such individuals. PMID:21206577

Girish, K.; Gangadhar, B.N.; Janakiramaiah, N.

2002-01-01

16

Ion sources for ion implantation technology (invited)  

SciTech Connect

Ion sources for ion implantation are introduced. The technique is applied not only to large scale integration (LSI) devices but also to flat panel display. For LSI fabrication, ion source scheduled maintenance cycle is most important. For CMOS image sensor devices, metal contamination at implanted wafer is most important. On the other hand, to fabricate miniaturized devices, cluster ion implantation has been proposed to make shallow PN junction. While for power devices such as silicon carbide, aluminum ion is required. For doping processes of LCD fabrication, a large ion source is required. The extraction area is about 150 cm × 10 cm, and the beam uniformity is important as well as the total target beam current.

Sakai, Shigeki, E-mail: sakai-shigeki@nissin.co.jp; Hamamoto, Nariaki; Inouchi, Yutaka; Umisedo, Sei; Miyamoto, Naoki [Nissin Ion Equipment co., ltd, 575 Kuze-Tonoshiro-cho Minami-ku, Kyoto 601-8205 (Japan)] [Nissin Ion Equipment co., ltd, 575 Kuze-Tonoshiro-cho Minami-ku, Kyoto 601-8205 (Japan)

2014-02-15

17

Ion sources for ion implantation technology (invited).  

PubMed

Ion sources for ion implantation are introduced. The technique is applied not only to large scale integration (LSI) devices but also to flat panel display. For LSI fabrication, ion source scheduled maintenance cycle is most important. For CMOS image sensor devices, metal contamination at implanted wafer is most important. On the other hand, to fabricate miniaturized devices, cluster ion implantation has been proposed to make shallow PN junction. While for power devices such as silicon carbide, aluminum ion is required. For doping processes of LCD fabrication, a large ion source is required. The extraction area is about 150 cm × 10 cm, and the beam uniformity is important as well as the total target beam current. PMID:24593650

Sakai, Shigeki; Hamamoto, Nariaki; Inouchi, Yutaka; Umisedo, Sei; Miyamoto, Naoki

2014-02-01

18

Study on application of aerospace technology to improve surgical implants  

NASA Technical Reports Server (NTRS)

The areas where aerospace technology could be used to improve the reliability and performance of metallic, orthopedic implants was assessed. Specifically, comparisons were made of material controls, design approaches, analytical methods and inspection approaches being used in the implant industry with hardware for the aerospace industries. Several areas for possible improvement were noted such as increased use of finite element stress analysis and fracture control programs on devices where the needs exist for maximum reliability and high structural performance.

Johnson, R. E.; Youngblood, J. L.

1982-01-01

19

Amplification, Technology, and Cochlear Implants for Infants.  

ERIC Educational Resources Information Center

Early amplification is crucial to efficient habilitation and development of oral communication skills in hearing-impaired infants. Initial evaluation and fitting of amplification is a joint effort by the audiologist, therapist, and parents, whether the child uses traditional hearing aids or cochlear implants, and should be supplemented by a…

Adam, Arlie J.

1993-01-01

20

Interactive technology assessment of paediatric cochlear implantation  

Microsoft Academic Search

Interactive technology assessment is a novel approach to evaluating (health) technology, which philosophically draws from the works of Rawls and Habermas. That is, it seeks to organise a practical setting for discursive ethics in order to find a legitimate basis for policy to be pursued when the technology under scrutiny features a moral controversy. Interactive technology assessment involves a cycle

Rob Reuzel

2004-01-01

21

The evolution of cochlear implant technology and its clinical relevance  

PubMed Central

The article presents a brief history of the development of the cochlear implant, from its beginnings to the present day. After a short description of the device, it describes the evolution of the technology for three of the top manufacturing companies, from the first model marketed, to the latest. It presents the technological advancements from one model to the next, taking into account the exterior design, processing capabilities and functionality.

Hainarosie, M; Zainea, V; Hainarosie, R

2014-01-01

22

Measurement of implant damage in sapphire with thermal wave technology  

SciTech Connect

This paper describes the use of thermal wave technology for monitoring implant damage in sapphire substrate wafers. The information obtained is not easily obtainable from other techniques, such as UV reflectance or IR reflectance measurements. In CMOS/SOS device and circuit fabrication it is often desirable to monitor the effects of implant damage in the underlying sapphire substrate and at the edge of the silicon epi islands before and after anneals at various temperatures. This is particularly relevant to radiation-hard devices fabricated on silicon-on-sapphire (SOS).

Wu, C.P.; Kolondra, F. (David Sarnoff Research Center, Princeton, NJ (USA))

1990-06-01

23

Optimal design of composite hip implants using NASA technology  

NASA Technical Reports Server (NTRS)

Using an adaptation of NASA software, we have investigated the use of numerical optimization techniques for the shape and material optimization of fiber composite hip implants. The original NASA inhouse codes, were originally developed for the optimization of aerospace structures. The adapted code, which was called OPORIM, couples numerical optimization algorithms with finite element analysis and composite laminate theory to perform design optimization using both shape and material design variables. The external and internal geometry of the implant and the surrounding bone is described with quintic spline curves. This geometric representation is then used to create an equivalent 2-D finite element model of the structure. Using laminate theory and the 3-D geometric information, equivalent stiffnesses are generated for each element of the 2-D finite element model, so that the 3-D stiffness of the structure can be approximated. The geometric information to construct the model of the femur was obtained from a CT scan. A variety of test cases were examined, incorporating several implant constructions and design variable sets. Typically the code was able to produce optimized shape and/or material parameters which substantially reduced stress concentrations in the bone adjacent of the implant. The results indicate that this technology can provide meaningful insight into the design of fiber composite hip implants.

Blake, T. A.; Saravanos, D. A.; Davy, D. T.; Waters, S. A.; Hopkins, D. A.

1993-01-01

24

Evolution and Acceptability of Medical Applications of RFID Implants Among Early Users of Technology  

Microsoft Academic Search

RFID as a wireless identification technology that may be combined with microchip implants have tremendous potential in today's market. Although these implants have their advantages and disadvantages, recent improvements how allowed for implants designed for humans. Focus was given to the use of RFID tags and its effects on technology and CRM through a case study on VeriChip™, the only

Alan D. Smith

2008-01-01

25

Adaptation of NASA technology for the optimum design of orthopedic knee implants.  

PubMed

NASA technology originally developed for designing aircraft turbine-engine blades has been adapted and applied to orthopedic knee implants. This article describes a method for tailoring an implant for optimal interaction with the environment of the tibia. The implant components are designed to control stresses in the bone for minimizing bone degradation and preventing failures. Engineers expect the tailoring system to improve knee prosthesis design and allow customized implants for individual patients. PMID:10150099

Saravanos, D A; Mraz, P J; Davy, D T; Hopkins, D A

1991-03-01

26

Evolution of Ion Implantation Technology and its Contribution to Semiconductor Industry  

NASA Astrophysics Data System (ADS)

Industrial aspects of the evolution of ion implantation technology will be reviewed, and their impact on the semiconductor industry will be discussed. The main topics will be the technology's application to the most advanced, ultra scaled CMOS, and to power devices, as well as productivity improvements in implantation technology. Technological insights into future developments in ion-related technologies for emerging industries will also be presented.

Tsukamoto, Katsuhiro; Kuroi, Takashi; Kawasaki, Yoji

2011-01-01

27

Maintenance ECT in Parkinson's disease  

Microsoft Academic Search

Summary.   Electroconvulsive therapy (ECT) has an anti-Parkinsonian effect. In two cases repeated single ECT, i.e. maintenance ECT (MECT),\\u000a caused different, hitherto unreported positive effects. One patient had either severe mental side effects from higher L-dopa\\u000a doses or intolerable parkinsonian symptoms on lower doses. MECT entailed a marked improvement in parkinsonian symptoms without\\u000a mental side effects. Another patient with depression as

P.-A. Fall; A.-K. Granérus

1999-01-01

28

Production technology for high efficiency ion implanted solar cells  

NASA Technical Reports Server (NTRS)

Ion implantation is being developed for high volume automated production of silicon solar cells. An implanter designed for solar cell processing and able to properly implant up to 300 4-inch wafers per hour is now operational. A machine to implant 180 sq m/hr of solar cell material has been designed. Implanted silicon solar cells with efficiencies exceeding 16% AM1 are now being produced and higher efficiencies are expected. Ion implantation and transient processing by pulsed electron beams are being integrated with electrostatic bonding to accomplish a simple method for large scale, low cost production of high efficiency solar cell arrays.

Kirkpatrick, A. R.; Minnucci, J. A.; Greenwald, A. C.; Josephs, R. H.

1978-01-01

29

[Manufacturing of mammary implants: a manufacturing of high technology].  

PubMed

The manufacturing of mammary implants is studied at each step: origin of the silicon, manufacturing of the shells, silicon gels and saline implants. All the process of this manufacturing is now normalised with a tracability that offer today to the surgeon high and homogen quality implants. PMID:16183186

Sitbon, E

2005-10-01

30

Adaptation of NASA technology for the optimization of orthopedic knee implants  

NASA Technical Reports Server (NTRS)

The NASA technology originally developed for the optimization of composite structures (engine blades) is adapted and applied to the optimization of orthopedic knee implants. A method is developed enabling the tailoring of the implant for optimal interaction with the environment of the tibia. The shape of the implant components are optimized, such that the stresses in the bone are favorably controlled to minimize bone degradation and prevent failures. A pilot tailoring system is developed and the feasibility of the concept is elevated. The optimization system is expected to provide the means for improving knee prosthesis and individual implant tailoring for each patient.

Saravanos, D. A.; Mraz, P. J.; Hopkins, D. A.

1991-01-01

31

Science and technology of biocompatible thin films for implantable biomedical devices.  

SciTech Connect

This presentation focuses on reviewing research to develop two critical biocompatible film technologies to enable implantable biomedical devices, namely: (1) development of bioinert/biocompatible coatings for encapsulation of Si chips implantable in the human body (e.g., retinal prosthesis implantable in the human eye) - the coating involves a novel ultrananocrystalline diamond (UNCD) film or hybrid biocompatible oxide/UNCD layered films; and (2) development of biocompatible films with high-dielectric constant and microfabrication process to produce energy storage super-capacitors embedded in the microchip to achieve full miniaturization for implantation into the human body.

Li, W.; Kabius, B.; Auciello, O.; Materials Science Division

2010-01-01

32

Implants  

MedlinePLUS

... palate, which can reduce your sense of taste. Self-esteem — Because implants are so much like your natural teeth, you will think about them less. Your self-esteem and confidence will be improved because you will ...

33

Advancing dental implant surface technology – From micron- to nanotopography  

Microsoft Academic Search

Current trends in clinical dental implant therapy include use of endosseous dental implant surfaces embellished with nanoscale topographies. The goal of this review is to consider the role of nanoscale topographic modification of titanium substrates for the purpose of improving osseointegration. Nanotechnology offers engineers and biologists new ways of interacting with relevant biological processes. Moreover, nanotechnology has provided means of

Gustavo Mendonça; Daniela B. S. Mendonça; Francisco J. L. Aragão; Lyndon F. Cooper

2008-01-01

34

IMAGE: A new type of implantable device uses flexible silicon technology.  

E-print Network

IMAGE: A new type of implantable device uses flexible silicon technology. Click here for more of flexible silicon technology for a medical application. "We believe that this technology may herald a new epileptic seizures, providing more precise control over deep brain stimulation, as well as other

Rogers, John A.

35

Nanomaterials and synergistic low-intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices.  

PubMed

Nanomaterials play a significant role in biomedical research and applications because of their unique biological, mechanical, and electrical properties. In recent years, they have been utilized to improve the functionality and reliability of a wide range of implantable medical devices ranging from well-established orthopedic residual hardware devices (e.g., hip implants) that can repair defects in skeletal systems to emerging tissue engineering scaffolds that can repair or replace organ functions. This review summarizes the applications and efficacies of these nanomaterials that include synthetic or naturally occurring metals, polymers, ceramics, and composites in orthopedic implants, the largest market segment of implantable medical devices. The importance of synergistic engineering techniques that can augment or enhance the performance of nanomaterial applications in orthopedic implants is also discussed, the focus being on a low-intensity direct electric current (LIDC) stimulation technology to promote the long-term antibacterial efficacy of oligodynamic metal-based surfaces by ionization, while potentially accelerating tissue growth and osseointegration. While many nanomaterials have clearly demonstrated their ability to provide more effective implantable medical surfaces, further decisive investigations are necessary before they can translate into medically safe and commercially viable clinical applications. The article concludes with a discussion about some of the critical impending issues with the application of nanomaterials-based technologies in implantable medical devices, and potential directions to address these. PMID:23335493

Shirwaiker, Rohan A; Samberg, Meghan E; Cohen, Paul H; Wysk, Richard A; Monteiro-Riviere, Nancy A

2013-01-01

36

Technological, biological, and acoustical constraints to music perception in cochlear implant users.  

PubMed

Despite advances in technology, the ability to perceive music remains limited for many cochlear implant users. This paper reviews the technological, biological, and acoustical constraints that make music an especially challenging stimulus for cochlear implant users, while highlighting recent research efforts to overcome these shortcomings. The limitations of cochlear implant devices, which have been optimized for speech comprehension, become evident when applied to music, particularly with regards to inadequate spectral, fine-temporal, and dynamic range representation. Beyond the impoverished information transmitted by the device itself, both peripheral and central auditory nervous system deficits are seen in the presence of sensorineural hearing loss, such as auditory nerve degeneration and abnormal auditory cortex activation. These technological and biological constraints to effective music perception are further compounded by the complexity of the acoustical features of music itself that require the perceptual integration of varying rhythmic, melodic, harmonic, and timbral elements of sound. Cochlear implant users not only have difficulty perceiving spectral components individually (leading to fundamental disruptions in perception of pitch, melody, and harmony) but also display deficits with higher perceptual integration tasks required for music perception, such as auditory stream segregation. Despite these current limitations, focused musical training programs, new assessment methods, and improvements in the representation and transmission of the complex acoustical features of music through technological innovation offer the potential for significant advancements in cochlear implant-mediated music perception. PMID:23665130

Limb, Charles J; Roy, Alexis T

2014-02-01

37

Surface characterization and biocompatibility of titanium alloys implanted with nitrogen by Hardion+ technology.  

PubMed

In this study, the new Hardion+ micro-implanter technology was used to modify surface properties of biomedical pure titanium (CP-Ti) and Ti-6Al-4V ELI alloy by implantation of nitrogen ions. This process is based on the use of an electron cyclotron resonance ion source to produce a multienergetic ion beam from multicharged ions. After implantation, surface analysis methods revealed the formation of titanium nitride (TiN) on the substrate surfaces. An increase in superficial hardness and a significant reduction of friction coefficient were observed for both materials when compared to non-implanted samples. Better corrosion resistance and a significant decrease in ion release rates were observed for N-implanted biomaterials due to the formation of the protective TiN layer on their surfaces. In vitro tests performed on human fetal osteoblasts indicated that the cytocompatibility of N-implanted CP-Ti and Ti-6Al-4V alloy was enhanced in comparison to that of the corresponding non treated samples. Consequently, Hardion+ implantation technique can provide titanium alloys with better qualities in terms of corrosion resistance, cell proliferation, adhesion and viability. PMID:22918550

Gordin, D M; Gloriant, T; Chane-Pane, V; Busardo, D; Mitran, V; Höche, D; Vasilescu, C; Drob, S I; Cimpean, A

2012-12-01

38

Biofilm Disrupting Technology for Orthopedic Implants: What’s on the Horizon?  

PubMed Central

The use of orthopedic implants in joints has revolutionized the treatment of patients with many debilitating chronic musculoskeletal diseases such as osteoarthritis. However, the introduction of foreign material into the human body predisposes the body to infection. The treatment of these infections has become very complicated since the orthopedic implants serve as a surface for multiple species of bacteria to grow at a time into a resistant biofilm layer. This biofilm layer serves as a protectant for the bacterial colonies on the implant making them more resistant and difficult to eradicate when using standard antibiotic treatment. In some cases, the use of antibiotics alone has even made the bacteria more resistant to treatment. Thus, there has been surge in the creation of non-antibiotic anti-biofilm agents to help disrupt the biofilms on the orthopedic implants to help eliminate the infections. In this study, we discuss infections of orthopedic implants in the shoulder then we review the main categories of anti-biofilm agents that have been used for the treatment of infections on orthopedic implants. Then, we introduce some of the newer biofilm disrupting technology that has been studied in the past few years that may advance the treatment options for orthopedic implants in the future. PMID:25705632

Connaughton, Alexander; Childs, Abby; Dylewski, Stefan; Sabesan, Vani J.

2014-01-01

39

Molecular dynamics study on splitting of hydrogen-implanted silicon in Smart-Cut® technology  

NASA Astrophysics Data System (ADS)

Defect evolution in a single crystal silicon which is implanted with hydrogen atoms and then annealed is investigated in the present paper by means of molecular dynamics simulation. By introducing defect density based on statistical average, this work aims to quantitatively examine defect nucleation and growth at nanoscale during annealing in Smart-Cut® technology. Research focus is put on the effects of the implantation energy, hydrogen implantation dose and annealing temperature on defect density in the statistical region. It is found that most defects nucleate and grow at the annealing stage, and that defect density increases with the increase of the annealing temperature and the decrease of the hydrogen implantation dose. In addition, the enhancement and the impediment effects of stress field on defect density in the annealing process are discussed. Project supported by the National Natural Science Foundation of China (No. 11372261), the Excellent Young Scientists Supporting Project of Science and Technology Department of Sichuan Province (No. 2013JQ0030), the Supporting Project of Department of Education of Sichuan Province (No. 2014zd3132), the Opening Project of Key Laboratory of Testing Technology for Manufacturing Process, Southwest University of Science and Technology-Ministry of Education (No. 12zxzk02), the Fund of Doctoral Research of Southwest University of Science and Technology (No. 12zx7106), and the Postgraduate Innovation Fund Project of Southwest University of Science and Technology (No. 14ycxjj0121).

Bing, Wang; Bin, Gu; Rongying, Pan; Sijia, Zhang; Jianhua, Shen

2015-03-01

40

Enhancement technology and outcomes: what professionals and researchers can learn from those skeptical about cochlear implants.  

PubMed

This text presents an overview of the bioethical debate on pediatric cochlear implants and pays particular attention to the analysis of the Deaf critique of implantation. It dismisses the idea that Deaf concerns are primarily about the upholding of Deaf culture and sign language. Instead it is argued that Deaf skepticism about child rehabilitation after cochlear surgery is well founded. Many Deaf people have lived experiences as subjects undergoing rehabilitation. It is not the cochlear technology in itself they view as problematic, but rather the subsequent rehabilitation process. Because they themselves have experienced what they describe as harmful effects which relate above all to the idea of normalization, they have articulated worries for the new generations of deaf children in need of rehabilitation following cochlear implant surgery. These insights have attracted little attention, but could represent relevant ethical questions of which both practitioners and researchers in the field of implantation might be aware. PMID:22976285

Kermit, Patrick

2012-12-01

41

A triple gate oxide CMOS technology using fluorine implant for system-on-a-chip  

Microsoft Academic Search

We have developed a triple gate oxide CMOS technology that integrates 0.10-?m gate length 1.2-V high-speed CMOS (tox of 1.9 nm), low-power CMOS (tox of 2.5 nm) and 2.5-V I\\/O transistors (tox of 5.0 nm). The key technology is fluorine implantation in order to fabricate 1.9-nm and 2.5-nm gate oxide simultaneously. We selectively implanted fluorine into low-power CMOS area and

Y. Goto; K. Imai; E. Hasegawa; T. Ohashi; N. Kimizuka; T. Toda; N. Hamanaka; T. Horiuchi

2000-01-01

42

Cochlear implants: the head-on collision between medical technology and the right to be deaf  

PubMed Central

The debate over using cochlear implants to help deaf people communicate with those who can hear continues to rage. Some have welcomed the new technology, but others say the deaf have their own culture and do not need to be "cured". PMID:9327803

Swanson, L

1997-01-01

43

A 50 GHz implanted base silicon bipolar technology with 35 GHz static frequency divider  

Microsoft Academic Search

A 0.5 ?m silicon bipolar technology for mixed digital\\/analogue RF applications is presented. Very steep base profiles are realized by ion implantation and subsequent base diffusion. Cut-off frequencies and maximum oscillation frequencies of 50 GHz and ECL gate delay of 16 ps are obtained without increasing the process complexity in comparison to a 0.8 ?m production technology. A static 2:1

J. Bok; A. Felder; T. F. Meister; M. Franosch; K. Aufinger; M. Wurzer; R. Schreiter; S. Boguth; L. Treitinger

1996-01-01

44

Implantable sensor technology: measuring bone and joint biomechanics of daily life in vivo  

PubMed Central

Stresses and strains are major factors influencing growth, remodeling and repair of musculoskeletal tissues. Therefore, knowledge of forces and deformation within bones and joints is critical to gain insight into the complex behavior of these tissues during development, aging, and response to injury and disease. Sensors have been used in vivo to measure strains in bone, intraarticular cartilage contact pressures, and forces in the spine, shoulder, hip, and knee. Implantable sensors have a high impact on several clinical applications, including fracture fixation, spine fixation, and joint arthroplasty. This review summarizes the developments in strain-measurement-based implantable sensor technology for musculoskeletal research. PMID:23369655

2013-01-01

45

Full chip implant correction with wafer topography OPC modeling in 2x nm bulk technologies  

NASA Astrophysics Data System (ADS)

Ionic implantation photolithography step considered to be non critical started to be influenced by unwanted overexposure by wafer topography with technology node downscaling evolution [1], [2]. Starting from 2xnm technology nodes, implant patterns modulated on wafer by classical implant proximity effects are also influenced by wafer topography which can cause drastic pattern degradation [2], [3]. This phenomenon is expected to be attenuated by the use of anti-reflecting coating but it increases process complexity and involves cost and cycle time penalty. As a consequence, computational lithography solutions are currently under development in order to correct wafer topographical effects on mask [3]. For ionic implantation source Drain (SD) on Silicon bulk substrate, wafer topography effects are the consequence of active silicon substrate, poly patterns, STI stack, and transitions between patterned wafer stack. In this paper, wafer topography aware OPC modeling flow taking into account stack effects for bulk technology is presented. Quality check of this full chip stack aware OPC model is shown through comparison of mask computational verification and known systematic defectivity on wafer. Also, the integration of topographical OPC model into OPC flow for chip scale mask correction is presented with quality and run time penalty analysis.

Michel, J.-C.; Le Denmat, J.-C.; Sungauer, E.; Robert, F.; Yesilada, E.; Armeanu, A.-M.; Entradas, J.; Sturtevant, J. L.; Do, T.; Granik, Y.

2013-09-01

46

CAD/CAM and telescopic technology: design options for implant-supported overdentures.  

PubMed

There are many options with respect to materials, construction methods, and design concepts for the technical implementation of implant-supported dental prostheses. Different methods of anchorage can be used to attach removable superstructures to implants. Telescopic crowns make it possible to fabricate inexpensive superstructures with precise and passive fit. Computer-aided design/computer-assisted manufacture (CAD/CAM) technology allows copings to be fabricated from materials such as zirconia or titanium. Moreover, CAD/CAM crown copings can serve as a base for fabricating customized ceramic replacement teeth. Different veneering techniques, such as pressed-on ceramics for zirconia cores, ensure a fast and economic work process. With the use of electroforming it is possible to manufacture highly precise secondary structures that ensure passive seating of the prosthesis in a stable position. This article demonstrates a restorative treatment option using current techniques with the aim of rehabilitation with an esthetic and functional implant-supported removable denture. PMID:19655559

Bergler, Michael; Holst, Stefan; Blatz, Markus B; Eitner, Stephan; Wichmann, Manfred

2008-01-01

47

A low-frequency versatile wireless power transfer technology for biomedical implants.  

PubMed

Implantable biomedical sensors and actuators are highly desired in modern medicine. In many cases, the implant's electrical power source profoundly determines its overall size and performance . The inductively coupled coil pair operating at the radio-frequency (RF) has been the primary method for wirelessly delivering electrical power to implants for the last three decades . Recent designs significantly improve the power delivery efficiency by optimizing the operating frequency, coil size and coil distance . However, RF radiation hazard and tissue absorption are the concerns in the RF wireless power transfer technology (RF-WPTT) , . Also, it requires an accurate impedance matching network that is sensitive to operating environments between the receiving coil and the load for efficient power delivery . In this paper, a novel low-frequency wireless power transfer technology (LF-WPTT) using rotating rare-earth permanent magnets is demonstrated. The LF-WPTT is able to deliver 2.967 W power at  ? 180 Hz to an 117.1 ? resistor over 1 cm distance with 50% overall efficiency. Because of the low operating frequency, RF radiation hazard and tissue absorption are largely avoided, and the power delivery efficiency from the receiving coil to the load is independent of the operating environment. Also, there is little power loss observed in the LF-WPTT when the receiving coil is enclosed by non-magnetic implant-grade stainless steel. PMID:23893211

Jiang, Hao; Zhang, Junmin; Lan, Di; Chao; Liou, Shyshenq; Shahnasser, Hamid; Fechter, Richard; Hirose, Shinjiro; Harrison, Michael; Roy, Shuvo

2013-08-01

48

Efficacy of ECT in Depression: A Meta-Analytic Review  

Microsoft Academic Search

This study analyzed the efficacy of electroconvulsive therapy (ECT) in depression by means a meta-analytic review of ran- domized controlled trials that compared ECT with simulated ECT or placebo or antidepressant drugs and by a complemen- tary meta-analytic review of nonrandomized controlled trials that compared ECT with antidepressants drugs. The review re- vealed a significant superiority of ECT in all

Daniel Pagnin; Stefano Pini; Giovanni Battista Cassano

2004-01-01

49

History of some early developments in ion-implantation technology leading to silicon transistor manufacturing  

Microsoft Academic Search

Ion implantation of dopant impurities to form p-n junctions and other doped regions in silicon transistors has evolved from an experimental curiosity in solid-state physics to become a dominant technology in today's integrated circuit manufacturing. This paper traces the key inventions and early developments in ion beam doping concepts from the early 1950's through the 1970's as they were applied

RICHARD B. FAIR

1998-01-01

50

Plasma-based ion implantation and deposition: A review of physics,technology, and applications  

SciTech Connect

After pioneering work in the 1980s, plasma-based ion implantation (PBII) and plasma-based ion implantation and deposition (PBIID) can now be considered mature technologies for surface modification and thin film deposition. This review starts by looking at the historical development and recalling the basic ideas of PBII. Advantages and disadvantages are compared to conventional ion beam implantation and physical vapor deposition for PBII and PBIID, respectively, followed by a summary of the physics of sheath dynamics, plasma and pulse specifications, plasma diagnostics, and process modeling. The review moves on to technology considerations for plasma sources and process reactors. PBII surface modification and PBIID coatings are applied in a wide range of situations. They include the by-now traditional tribological applications of reducing wear and corrosion through the formation of hard, tough, smooth, low-friction and chemically inert phases and coatings, e.g. for engine components. PBII has become viable for the formation of shallow junctions and other applications in microelectronics. More recently, the rapidly growing field of biomaterial synthesis makes used of PBII&D to produce surgical implants, bio- and blood-compatible surfaces and coatings, etc. With limitations, also non-conducting materials such as plastic sheets can be treated. The major interest in PBII processing originates from its flexibility in ion energy (from a few eV up to about 100 keV), and the capability to efficiently treat, or deposit on, large areas, and (within limits) to process non-flat, three-dimensional workpieces, including forming and modifying metastable phases and nanostructures. We use the acronym PBII&D when referring to both implantation and deposition, while PBIID implies that deposition is part of the process.

Pelletier, Jacques; Anders, Andre

2005-05-16

51

Automatic implantable cardioverter defibrillator in electroconvulsive therapy.  

PubMed

As the number of patients with implantable cardiac devices increases so too does the frequency with which these individuals present for electroconvulsive therapy (ECT). The rationale for deactivating an automatic implantable cardioverter defibrillator before ECT has been made based on the concern that artifacts generated during treatment could be interpreted as a treatable rhythm by the internal device, resulting in a discharge. We believe that the risk of inappropriate discharge during ECT is very low and outweighed by the considerable benefit of an active device being able to more quickly treat a malignant dysrhythmia. PMID:25148111

Bryson, Ethan O; Popeo, Dennis M; Briggs, Mimi C; Pasculli, Rosa M; Kellner, Charles H

2015-03-01

52

Improvement of P-N Junction Leakage and Reduction in Interface State Density in Transistors by Cryo Implantation Technology  

NASA Astrophysics Data System (ADS)

Cryo implantation by a rapid thermal annealing process was applied to achieve defect-free shallow junctions. Boron ions were implanted in (100) Si substrates cooled using liquid nitrogen, with temperature controlled at -160 °C or lower during ion implantation. It was found that an amorphous layer was formed by boron implantation and that the amorphous layer completely recovered to single crystals after annealing at 900 °C for 30 s. No dislocation was observed in the implanted layer. It was also found that the thermal diffusion of boron was suppressed by cryo implantation. Furthermore, cryo implantation was found to be very effective in reducing the density of defects, and P-N junction leakage was reduced by one order of magnitude compared with that in the case of room temperature implantation. These results suggest that the transient enhanced diffusion of boron can be reduced by suppressing vacancy migration toward the surface during implantation. Moreover, the substrate-cooling effect is very effective for improving surface roughness, and it is a very effective technology not only for reducing Si/SiO2 interface state density but also for improving the reliability of gate oxide.

Murakoshi, Atsushi; Iwase, Masao; Niiyama, Hiromi; Tomita, Mitsuhiro; Suguro, Kyoichi

2013-10-01

53

Ion beam technology applications study. [ion impact, implantation, and surface finishing  

NASA Technical Reports Server (NTRS)

Specific perceptions and possible ion beam technology applications were obtained as a result of a literature search and contact interviews with various institutions and individuals which took place over a 5-month period. The use of broad beam electron bombardment ion sources is assessed for materials deposition, removal, and alteration. Special techniques examined include: (1) cleaning, cutting, and texturing for surface treatment; (2) crosslinking of polymers, stress relief in deposited layers, and the creation of defect states in crystalline material by ion impact; and (3) ion implantation during epitaxial growth and the deposition of neutral materials sputtered by the ion beam. The aspects, advantages, and disadvantages of ion beam technology and the competitive role of alternative technologies are discussed.

Sellen, J. M., Jr.; Zafran, S.; Komatsu, G. K.

1978-01-01

54

Utilization of digital technologies for fabrication of definitive implant-supported restorations.  

PubMed

The introduction 7 years ago of specially coded healing abutments dramatically simplified the task of obtaining implant impressions. Such coded abutments eliminated the need for impression copings, instead enabling supragingival impressions to be made and sent to the laboratory for fabrication of patient-specific abutments and restorations. Combining this technology with digital oral scanning has the potential to further simplify the time between impression-making and delivery of a definitive restoration, and it offers additional benefits to both patients and clinicians. This article explains how oral scanners can be used to obtain digital impressions of encoded healing abutments. A case report illustrating this approach is also presented. PMID:23025311

Ramsey, Christopher D; Ritter, Robert G

2012-10-01

55

A programmed release multi-drug implant fabricated by three-dimensional printing technology for bone tuberculosis therapy  

Microsoft Academic Search

In the world, bone tuberculosis is still very difficult to treat and presents a challenge to clinicians. In this study, we utilized 3D printing technology to fabricate a programmed release multi-drug implant for bone tuberculosis therapy. The construction of the drug implant was a multi-layered concentric cylinder divided into four layers from the center to the periphery. Isoniazid and rifampicin

Weigang Wu; Qixin Zheng; Xiaodong Guo; Jianhua Sun; Yudong Liu

2009-01-01

56

Technology Advances and Challenges in Hermetic Packaging for Implantable Medical Devices  

Microsoft Academic Search

\\u000a Many implantable medical devices contain sophisticated electronic circuits. Hermetic packaging is required to provide the\\u000a implant’s electronic circuitry with protection from the harsh environment of the human body. This chapter provides a review\\u000a of available hermetic sealing methods and their applications. General considerations of implantable medical device packaging\\u000a are discussed. Various testing methods applicable to the packaging of implantable medical

Guangqiang Jiang; David D. Zhou

2010-01-01

57

Design of a miniature implantable left ventricular assist device using CAD/CAM technology.  

PubMed

In this study, we developed a new miniature motor-driven pulsatile left ventricular assist device (LVAD) for implantation into a Japanese patient of average build by means of computer-aided design and manufacturing (CAD/CAM) technology. A specially designed miniature ball-screw and a high-performance brushless DC motor were used in an artificial heart actuator to allow miniaturization. A blood pump chamber (stroke volume 55 ml) and an inflow and outflow port were designed by computational fluid dynamics (CFD) analysis. The geometry of the blood pump was evaluated using the value of index of pump geometry (IPG) = (Reynolds shear stress) x (occupied volume) as a quantitative index for optimization. The calculated value of IPG varied from 20.6 Nm to 49.1 Nm, depending on small variations in pump geometry. We determined the optimum pump geometry based on the results of quantitative evaluation using IPG and qualitative evaluation using the flow velocity distribution with blood flow tracking. The geometry of the blood pump that gave lower shear stress had more optimum spiral flow around the diaphragm-housing (D-H) junction. The volume and weight of the new LVAD, made of epoxy resin, is 309 ml and 378 g, but further miniaturization will be possible by improving the geometry of both the blood pump and the back casing. Our results show that our new design method for an implantable LVAD using CAD/CAM promises to improve blood compatibility with greater miniaturization. PMID:14598098

Okamoto, Eiji; Hashimoto, Takuya; Mitamura, Yoshinori

2003-01-01

58

Implantable Microimagers  

PubMed Central

Implantable devices such as cardiac pacemakers, drug-delivery systems, and defibrillators have had a tremendous impact on the quality of live for many disabled people. To date, many devices have been developed for implantation into various parts of the human body. In this paper, we focus on devices implanted in the head. In particular, we describe the technologies necessary to create implantable microimagers. Design, fabrication, and implementation issues are discussed vis-à-vis two examples of implantable microimagers; the retinal prosthesis and in vivo neuro-microimager. Testing of these devices in animals verify the use of the microimagers in the implanted state. We believe that further advancement of these devices will lead to the development of a new method for medical and scientific applications.

Ng, David C.; Tokuda, Takashi; Shiosaka, Sadao; Tano, Yasuo; Ohta, Jun

2008-01-01

59

ECT AND PLATELET 5HT UPTAKE IN MAJOR DEPRESSION  

PubMed Central

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The mechanism of antidepressant action of ECT is not clear. The present work was undertaken with the aim to study the active platelet 5-HT uptake and the effect of ECT on it in patients of major depression. 15 patients of major depression (DSM-lll-R) and equal number of age and sex-matched controls were included in the study. Active platelet 5-HT uptake was determined before ECT, after a course of ECT and 7 days after last ECT. Platelet 5-HT uptake was. significantly lower in der essives than normal controls. After ECT treatment there was significant increase in 5-HT uptake which came down to pretreatment level after 1 week of last ECT. The effect of ECT on serotonergic system is discussed. PMID:21584091

Dalal, P.K.; Lal, Narottam; Trivedi, J.K.; Seth, P.K.; Agarwal, A.K.; Khalid, Abdul

1997-01-01

60

Simultaneous e ects of homogenization and vanishing viscosity  

E-print Network

Simultaneous e#11;ects of homogenization and vanishing viscosity in fully nonlinear elliptic simultaneous e#11;ects of homogenization and vanishing viscosity in uniformly and degenerate elliptic partial possible cases. Key Words: Homogenization, vanishing viscosity, elliptic equations, viscosity solu- tions

Ishii, Hitoshi

61

ECT Box Meals Menu NAME: ROOM: DATE: _______  

E-print Network

7559 BEVERAGES: (Limit 1) 2% Milk Whole Milk Skim Milk Chocolate Milk Lactaid Milk Orange Juice Apple Pineapple Grapes Orange Banana Apple ECT Box Meals Menu NAME: ROOM: DATE: _______ Please circle selections Lactaid Milk Orange Juice Apple Juice Cranberry Juice Prune Juice SIDES (Limit 1) Lorna Doones Graham

Oliver, Douglas L.

62

Sonoluminescence | a QED vacuum e ect?  

E-print Network

Sonoluminescence | a QED vacuum e#11;ect? Matt Visser Physics Department Washington University Sciama (SISSA, Trieste) UMSL/U Maryland November 1999. #12; Abstract: Sonoluminescence occurs when sound wave (about 40 kHz). In stable single-bubble sonoluminescence, every time the bubble goes through

Visser, Matt

63

Low-cost ion implantation and annealing technology for solar cells  

NASA Technical Reports Server (NTRS)

Ion implantation and thermal annealing techniques for processing junctions and back surface layers in solar cells are discussed. Standard 10 keV (31)p(+) junction implants and 25 keV (11)B(+) back surface implants in combination with three-step furnace annealing are used for processing a range of silicon materials and device structures. Cells with efficiencies up to 16.5% AM1 are being produced, and large-area terrestrial cells with implanted junctions and back fields being fabricated in pilot production exhibit average efficiencies in excess of 15% AM1. Thermal annealing methods for removal of the radiation damage caused by implantation should be replaced by transient processing techniques in future production. Design studies have been completed for solar cell processing implanters to support 10 MW/yr and 100 MW/yr production lines, and analyses indicate that implantation costs can be reduced to approximately 1 cent/watt.

Kirkpatrick, A. H.; Minnucci, J. A.; Greenwald, A. C.

1980-01-01

64

Annex A: FAU Grading System ECTS-credits  

E-print Network

Annex A: FAU Grading System ECTS-credits ECTS, the European Credit Transfer and Accumulation System, was developed by the Commission of the European Community in order to provide common procedures to guarantee, and transferring them from one institution to another. In ECTS, 60 credits represent the workload of a full year

Herrmann, Samuel

65

Medical student knowledge and attitudes regarding ECT prior to and after viewing ECT scenes from movies.  

PubMed

We surveyed samples of medical students in the United Kingdom (U.K.) and Australia, prior to their psychiatry placement, to ascertain views about electroconvulsive therapy (ECT) and the effect on those views of watching ECT scenes in movies. A 26-item questionnaire was constructed by the authors and administered to the students. At set times during the questionnaire, students were asked to view five movie clips showing, or making reference to, ECT. The clips were from Return to Oz, The Hudsucker Proxy, Ordinary People, One Flew Over the Cuckoo's Nest, and Beverly Hillbillies. Ninety-four students participated in the study. Levels of knowledge about the indications, side effects, and mode of administration were poor, and attitudes were generally negative. Viewing the ECT scenes influenced attitudes toward the treatment; after viewing, one-third of the students decreased their support for ECT, and the proportion of students who would dissuade a family member or friend from having ECT rose from less than 10% to almost 25%. PMID:11925521

Walter, Garry; McDonald, Andrew; Rey, Joseph M; Rosen, Alan

2002-03-01

66

Racial disparity and technology diffusion: the case of cardioverter defibrillator implants, 1996-2001.  

PubMed Central

BACKGROUND: Although implantable cardioverter defibrillator (ICD) therapy is widely endorsed for preventing sudden cardiac death (SCD), prior research documented a large black-white disparity in ICD therapy among the elderly. No studies have examined this disparity among nonelderly adults or over time as ICD therapy became widely diffused. OBJECTIVE: This study compares disparity in use of ICD therapy for 1996-1998 to 1999-2001 between African Americans and other adults. METHODS: The National Hospital Discharge Survey is used to compare ICD utilization between black and other adults diagnosed with ventricular tachycardia, ventricular fibrillation or cardiac arrest. RESULTS: Adjusting for patient and hospital characteristics, ICD use per 100 at-risk patients rose from 11.0 to 27.3 among African Americans and from 24.0 to 37.5 among other adults between 1996-1998 and 1999-2001. Although the disparity was evident throughout the study period, it declined by 40%. Compared with their nonblack counterparts, black adults at risk for SCD were five years younger on average (p < 0.01) and more likely to be female (p < 0.01). CONCLUSIONS: As ICD therapy became more widely available, use of this technology increased faster for black versus other adults, and the disparity in use declined but was not eliminated. Policymakers and clinicians should focus on increasing access among underserved populations to promising new technologies. Research focusing only on the elderly may miss important racial disparities when there is a race difference in the age distribution of disease risk. Further research should explore the relationship of technology diffusion to disparities in health service use. PMID:17393943

Stanley, Ava; DeLia, Derek; Cantor, Joel C.

2007-01-01

67

Plasma-based ion implantation: a valuable technology for the elaboration of innovative materials and nanostructured thin films  

NASA Astrophysics Data System (ADS)

Plasma-based ion implantation (PBII), invented in 1987, can now be considered as a mature technology for thin film modification. After a brief recapitulation of the principle and physics of PBII, its advantages and disadvantages, as compared to conventional ion beam implantation, are listed and discussed. The elaboration of thin films and the modification of their functional properties by PBII have already been achieved in many fields, such as microelectronics (plasma doping/PLAD), biomaterials (surgical implants, bio- and blood-compatible materials), plastics (grafting, surface adhesion) and metallurgy (hard coatings, tribology), to name a few. The major advantages of PBII processing lie, on the one hand, in its flexibility in terms of ion implantation energy (from 0 to 100 keV) and operating conditions (plasma density, collisional or non-collisional ion sheath), and, on the other hand, in the easy transferrability of processes from the laboratory to industry. The possibility of modifying the composition and physical nature of the films, or of drastically changing their physical properties over several orders of magnitude makes this technology very attractive for the elaboration of innovative materials, including metastable materials, and the realization of micro- or nanostructures. A review of the state of the art in these domains is presented and illustrated through a few selected examples. The perspectives opened up by PBII processing, as well as its limitations, are discussed.

Vempaire, D.; Pelletier, J.; Lacoste, A.; Béchu, S.; Sirou, J.; Miraglia, S.; Fruchart, D.

2005-05-01

68

Highly Reliable Dynamic Random Access Memory Technology for Application Specific Memory with Dual Nitrogen Concentration Gate Oxynitrides Using Selective Nitrogen Implantation  

Microsoft Academic Search

A polymetal dual gate dynamic random access memory (DRAM) for application specific memory (ASM) with dual nitrogen concentrated oxynitrides was developed for the first time. This technology uses selective nitrogen implantation performed just after gate oxidation. The nitrogen concentration of p-type metal oxide semiconductor (PMOS) in gate dielectric combined with nitrogen implantation and NO (nitric oxide) annealing is sufficiently high

Taro Sugizaki; Atsushi Murakoshi; Ryota Katsumata; Manabu Kojima; Tetsu Tanaka; Toshiro Nakanishi; Yasuo Nara

2003-01-01

69

Applied Quantum X Implant System: Technology Enhancements to Enable Production-Worthy Performance at the 45 nm Node  

NASA Astrophysics Data System (ADS)

Mechanical scanning of the wafer in 2 dimensions is one approach that has been used to achieve single wafer processing for high current ion implantation. This approach simplifies the beamline design, compared to scanned beam or ribbon beam architectures, but has required a number of new technologies and methods in the scanner hardware and in dosimetry control. The Applied® Quantum X Implant system was designed to incorporate these new technologies, and has achieved the process performance and low energy productivity required for advanced junction formation at the 65 nm technology node. Since its introduction, extensive qualification and development work has been carried out, to extend its capability to the next technology generation. A number of further innovations and improvements to the beamline and platform have been developed, extending its throughput and process control capability to be production-worthy at 45 nm. This paper will review the process control challenges associated with the 2d mechanical scanning approach and the new methods and hardware that have recently been implemented on the Applied Quantum X Implant system. The theory and design of the enhancements will be described and illustrated with process data in the areas of angle control, dosimetry and energy purity.

Murrell, Adrian; Edwards, Peter; Goldberg, Richard; Banks, Peter; Mitchell, Bob; Collart, Erik; Morley, Sean; Ryding, Geoffrey; Smick, Theodore; Farley, Marvin; Sakase, Takao; Hacker, David; Kindersley, Peter

2006-11-01

70

Rationale for the Use of CAD/CAM Technology in Implant Prosthodontics  

PubMed Central

Despite the predictable longevity of implant prosthesis, there is an ongoing interest to continue to improve implant prosthodontic treatment and outcomes. One of the developments is the application of computer-aided design and computer-aided manufacturing (CAD/CAM) to produce implant abutments and frameworks from metal or ceramic materials. The aim of this narrative review is to critically evaluate the rationale of CAD/CAM utilization for implant prosthodontics. To date, CAD/CAM allows simplified production of precise and durable implant components. The precision of fit has been proven in several laboratory experiments and has been attributed to the design of implants. Milling also facilitates component fabrication from durable and aesthetic materials. With further development, it is expected that the CAD/CAM protocol will be further simplified. Although compelling clinical evidence supporting the superiority of CAD/CAM implant restorations is still lacking, it is envisioned that CAD/CAM may become the main stream for implant component fabrication. PMID:23690778

Abduo, Jaafar; Lyons, Karl

2013-01-01

71

An Ultrasound Assisted Anchoring Technique (BoneWelding Technology) for Fixation of Implants to Bone - A Histological Pilot Study in Sheep.  

PubMed

The BoneWelding((R)) Technology offers new opportunities to anchor implants within bone. The technology melted the surface of biodegradable polymer pins by means of ultrasound energy to mould material into the structures of the predrilled bone. Temperature changes were measured at the sites of implantation in an in vitro experiment. In the in vivo part of the study two types of implants were implanted in the limb of sheep to investigate the biocompatibility of the method. One implant type was made of PL-DL-lactide (PLA), the second one was a titanium core partially covered with PLA. Healing period was 2 and 6 months, with 3 sheep per group. Bone samples were evaluated radiologically, histologically and histomorphometrically for bone remodeling and inflammatory reactions. Results demonstrated mild and short temperature increase during insertion. New bone formed at the implant without evidence of inflammatory reaction. The amount of adjacent bone was increased compared to normal cancellous bone. It was concluded that the BoneWelding((R)) Technology proved to be a biocompatible technology to anchor biodegradable as well as titanium-PLA implants in bone. PMID:19572033

Langhoff, Jens D; Kuemmerle, Jan M; Mayer, Joerg; Weber, Urs; Berra, Milica; Mueller, Jessika M; Kaestner, Sabine B; Zlinszky, Katalin; Auer, Joerg A; von Rechenberg, Brigitte

2009-01-01

72

An Ultrasound Assisted Anchoring Technique (BoneWelding® Technology) for Fixation of Implants to Bone – A Histological Pilot Study in Sheep  

PubMed Central

The BoneWelding® Technology offers new opportunities to anchor implants within bone. The technology melted the surface of biodegradable polymer pins by means of ultrasound energy to mould material into the structures of the predrilled bone. Temperature changes were measured at the sites of implantation in an in vitro experiment. In the in vivo part of the study two types of implants were implanted in the limb of sheep to investigate the biocompatibility of the method. One implant type was made of PL-DL-lactide (PLA), the second one was a titanium core partially covered with PLA. Healing period was 2 and 6 months, with 3 sheep per group. Bone samples were evaluated radiologically, histologically and histomorphometrically for bone remodeling and inflammatory reactions. Results demonstrated mild and short temperature increase during insertion. New bone formed at the implant without evidence of inflammatory reaction. The amount of adjacent bone was increased compared to normal cancellous bone. It was concluded that the BoneWelding® Technology proved to be a biocompatible technology to anchor biodegradable as well as titanium-PLA implants in bone. PMID:19572033

Langhoff, Jens D; Kuemmerle, Jan M; Mayer, Joerg; Weber, Urs; Berra, Milica; Mueller, Jessika M; Kaestner, Sabine B; Zlinszky, Katalin; Auer, Joerg A; von Rechenberg, Brigitte

2009-01-01

73

Cochlear Implants  

MedlinePLUS

... Medical Devices Products and Medical Procedures Implants and Prosthetics Cochlear Implants Cochlear Implants View movie of the ... More in Products and Medical Procedures Implants and Prosthetics Cochlear Implants What is a Cochlear Implant? Benefits ...

74

Glucocorticoid mechanisms may contribute to ECT-induced retrograde amnesia  

Microsoft Academic Search

Rationale  Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia.Objectives  Using mifepristone (a glucocorticoid receptor antagonist) as a chemical probe, we sought to examine steroid mechanisms in an animal model of ECT-induced

Nandakumar Nagaraja; Chittaranjan Andrade; Suresh Sudha; Nagendra Madan Singh; J. Suresh Chandra; B. V. Venkataraman

2007-01-01

75

Flow pattern identification of fluidized beds using ECT  

NASA Astrophysics Data System (ADS)

Electrical capacitance tomography (ECT) was applied in measuring solids distribution in square circulating fluidized beds. The fluidization conditions varied from bubbling fluidized bed to circulating fluidized bed. In the whole range of fluidization conditions, ECT was able to instantaneously provide the solids concentration and voids distributions in the fluidized beds. According to the acquired data from ECT and reconstructed image, different fluidization regimes can also be identified.

Liu, S.; Yang, W. Q.; Wang, H.; Yan, G.; Pan, Z.

2001-04-01

76

Representation of two-dimensional ion implantation rest distributions by Pearson distribution curves for silicon technology  

NASA Astrophysics Data System (ADS)

This is the second of two papers concerned with fitting Pearson curves to Monte Carlo simulations of implants into amorphous targets. In the first paper [ Solid-St. Electron.35, 1151 (1992)] it was shown that accurate Pearson curve fitting to projected range profiles is possible when implant profiles are available for which optimised moments can be generated. In the present paper we extend the fitting to simulations of two-dimensional rest distributions. Comparisons are made between Pearson curve fits and the original high-resolution implant profiles, in two-dimensions, for the ions B and As implanted into amorphous silicon. The profiles were derived from Monte Carlo simulations, each of one million ion trajectories. Fit coefficients are provided that allow the regeneration of the moment surfaces for the depth and implantation energy dependent lateral straggle and lateral kurtosis for the ions B, P, As and Sb implanted, with energies in the range 25-300 keV, into targets of amorphous silicon, silicon dioxide and silicon nitride. The depth-dependent lateral distribution is then constructed using symmetrical Pearson curves driven by analytical formulae for the moment surfaces. The two-dimensional rest distribution is then reconstructed from the product of this depth-dependent lateral distribution and the projected range distribution derived in the first paper.

Bowyer, M. D. J.; Ashworth, D. G.; Oven, R.

1996-01-01

77

SEIZURE DURATION AND RELATED ISSUES IN ECT FOR ENDOGENOUS DEPRESSION  

PubMed Central

SUMMARY In a study comparing sinusoidal wave and brief-pulse ECT in endogenous depression, seizure duration was monitored by the cuff method in 29 patients over 180 treatment sessions. Mean seizure duration across all treatments was 26.5 secs, and the mean for individual patients across their ECT course ranged from a minimum of 15.7 secs to maximum of38.5 secs. Regression analysis found no variable which significantly predicted mean seizure duration. Of the 22 good responders in the study, response to ECT was associated with a mean seizure duration of secs in 1 patient, ando cs in 11 patients; as just 2 of 7poor responders to ECT had a mean seizure duration of <20 secs in 1 patients, <25 secs in 11 patients, of the 22 good responders in the study; as just 2 of 7 poor responders to ECT had a mean seizure duration of <25 secs, it appears that a cuff seizure duration of over 20 secs may suffice for the seizure to be therapeutic in depression. With (constant current) brief pulse ECT, seizure threshold significantly increased with successive ECTs; thresholds did not however differ between the good and poor responders. There was a trend for seizure duration to decrease over time; again, good and poor responders did not differ. These findings provide little support for the anticonvulsant hypothesis for the antidepressant effect of ECT, but support the literature that ECT exerts an anticonvulsant effect. PMID:21776168

Andrade, Chittaranjan

1993-01-01

78

Plasma Implantation Technology for Upcoming Ultra Shallow and Highly Doped Fully Depleted Silicon On Insulator Transistors  

NASA Astrophysics Data System (ADS)

To face the continuous dimensions downscaling for upcoming semiconductor devices, we have investigated a plasma immersion ion implantation way and have compared the results to a conventional one. This new implantation method allows, in particular, high and thin doping concentration to field source and drain requirements for 32 nm node and below. In addition to this key step, a silicon selective epitaxy growth has been performed. Thus, n-type and p-type ion implantations have been carried out on thin blanket SOI substrates in Pulsion® plasma ion implantation tool manufactured by Ion Beam Services, with AsH3, BF3 or B2H6 precursors. Then a recrystallization annealing followed by silicon selective epitaxial growth has been performed in a reduced pressure chemical vapor deposition tool. Regarding n-type implantation we observed a poly-silicon growth in areas where the top silicon has been amorphous down to the buried oxide and a mono-silicon growth for areas where the top silicon has not been completely amorphous. Indeed, in this case recrystallization annealing was not sufficient to allow lengthwise solid phase epitaxy growth whereas there were no difficulties for axial one. Regarding p-type implantations no epitaxial growths have been observed at all. This lack of growth cannot be explained by a complete silicon amorphization which would have led to a growth of poly-silicon like for n-type implantation. According to our first results this growth vacancy could be explained by the very high boron atoms concentration on the substrate surface. The latter being resistant to HF-last cleaning could thus block silicon nucleation. However some rinsing processes, more or less aggressive, have been tested to remove this boron silicon alloy layer. Among these different tests, hydrochloric or plasma etching have provided, in some specific cases, promising results allowing an epitaxial silicon growth.

Gonzatti, Frederic; Milési, Frederic; Delaye, Vincent; Duchaine, Julian; Torregrosa, Frank; Etienne, Hasnaa; Yckache, Karim

2011-01-01

79

Estimation of Nitrogen Ion Energy in Sterilization Technology by Plasma Based Ion Implantation  

NASA Astrophysics Data System (ADS)

Plasma based ion implantation (PBII) with negative voltage pulses to the test specimen has been applied to the sterilization process as a technique suitable for three-dimensional work pieces. Pulsed high negative voltage (5 ?s pulse width, 300 pulses/s, -800 V to -15 kV) was applied to the electrode in this process at a gas pressure of 2.4 Pa of N2. We found that the PBII process, in which N2 gas self-ignitted plasma generated by only pulsed voltages is used, reduces the number of active Bacillus pumilus cell. The number of bacteria survivors was reduced by 10-5 x with 5 min exposure. Since the ion energy is the most important processing parameter, a simple method to estimate the nitrogen ion energy from distribution of nitrogen atoms in Si implanted by PBII was developed. The implanted ion energy is discussed from the SIMS in depth profiles.

Kondou, Youhei; Nakashima, Takeru; Tanaka, Takeshi; Takagi, Toshinori; Watanabe, Satoshi; Ohkura, Kensaku; Shibahara, Kentaro; Yokoyama, Shin

80

Polymeric heart valves for surgical implantation, catheter-based technologies and heart assist devices.  

PubMed

Efficient function and long-term durability without the need for anticoagulation, coupled with the ability to be accommodated in many different types of patient, are the principal requirements of replacement heart valves. Although the clinical use of valves appeared to have remained steady for several decades, the evolving demands for the elderly and frail patients typically encountered in the developed world, and the needs of much younger and poorer rheumatic heart disease patients in the developing world have now necessitated new paradigms for heart valve technologies and associated materials. This includes further consideration of durable elastomeric materials. The use of polymers to produce flexible leaflet valves that have the benefits of current commercial bioprosthetic and mechanical valves without any of their deficiencies has been held desirable since the mid 1950s. Much attention has been focused on thermoplastic polyurethanes in view of their generally good physico-chemical properties and versatility in processing, coupled with the improving biocompatibility and stability of recent formulations. Accelerated in vitro durability of between 600 and 1000 million cycles has been achieved using polycarbonate urethanes, and good resistance to degradation, calcification and thrombosis in vivo has been shown with some polysiloxane-based polyurethanes. Nevertheless, polymeric valves have remained relegated to use in temporary ventricular assist devices for bridging heart failure patients to transplantation. Some recent studies suggest that there is a greater degree of instability in thermoplastic materials than hitherto believed so that significant challenges remain in the search for the combination of durability and biocompatibility that would allow polymeric valves to become a clinical reality for surgical implantation. Perhaps more importantly, they could become candidates for use in situations where minimally invasive transcatheter procedures are used to replace diseased valves. Being amenable to relatively inexpensive mass production techniques, the attainment of this goal could benefit very large numbers of patients in developing and emerging countries who currently have no access to treatment for rheumatic heart disease that is so prevalent in these areas. This review discusses the evolution and current status of polymeric valves in wide-ranging circumstances. PMID:25443788

Bezuidenhout, Deon; Williams, David F; Zilla, Peter

2015-01-01

81

The controlled-releasing drug implant based on the three dimensional printing technology: Fabrication and properties of drug releasing in vivo  

Microsoft Academic Search

Three dimensional (3D) printing technology was utilized to fabricate a new type of drug implant with complicated architectures,\\u000a employing levofloxacin (LVFX) and rifampicine (RFP) as model drugs. The prepared drug implant prototype consists of a double-layer\\u000a structure, of which the upper region is a reservoir system containing RFP and the lower region is a matrix one containing\\u000a LVFX. The release

Weigang Wu; Qixin Zheng; Xiaodong Guo; Weidong Huang

2009-01-01

82

Cochlear Implants  

MedlinePLUS

Cochlear Implants Cochlear Implants Patient Health Information News media interested in covering the latest from AAO-HNS/F can ... only with a cochlear implant. How do cochlear implants work? Cochlear implants bypass damaged hair cells and ...

83

Breast Implants  

MedlinePLUS

... in women with breast implants. Outline the regulatory history of breast implants in the United States. Encourage reporting ... Medical Procedures Implants and Prosthetics Breast Implants Regulatory History of Breast Implants in the U.S. Saline-Filled Breast ...

84

The Effect of Technology and Testing Environment on Speech Perception Using Telehealth with Cochlear Implant Recipients  

ERIC Educational Resources Information Center

Purpose: In this study, the authors evaluated the effect of remote system and acoustic environment on speech perception via telehealth with cochlear implant recipients. Method: Speech perception was measured in quiet and in noise. Systems evaluated were Polycom visual concert (PVC) and a hybrid presentation system (HPS). Each system was evaluated…

Goehring, Jenny L.; Hughes, Michelle L.; Baudhuin, Jacquelyn L.; Valente, Daniel L.; McCreery, Ryan W.; Diaz, Gina R.; Sanford, Todd; Harpster, Roger

2012-01-01

85

Introduction to Special Issue on Implantable Electronics With great advances in electronics and electrode technologies, it has become possible  

E-print Network

in the field of implantable systems is the cardiac pacemaker, which has been implanted in countless patients7 Introduction to Special Issue on Implantable Electronics With great advances in electronics and clinical practices through the development of intelligent pacemaker, cochlear implant, neural prosthesis

Bhunia, Swarup

86

Informed consent and ECT: how much information should be provided?  

PubMed

Obtaining informed consent before providing treatment is a routine part of modern clinical practice. For some treatments, however, there may be disagreement over the requirements for 'informed' consent. Electroconvulsive therapy (ECT) is one such example. Blease argues that patients 'should surely be privy to the matters of fact that: (1) there is continued controversy over the effectiveness of ECT; (2) there is orthodox scientific consensus that there is currently no acknowledged explanation for ECT and (3) there is a serious (mainstream) debate over whether the response to ECT may be a placebo response.' Before embracing these suggestions, two key questions must be asked. Are these claims a reasonable representation of current ECT research? And if so, will this information be of benefit to patients? The evidence-based support for ECT from both National Institute for Health and Care Excellence and the Royal College of Psychiatrists appears to undermine the validity of claims (1) and (3), and therefore the rationale for providing this information. Concerning assertion (2), it is true that the mechanism by which ECT has its therapeutic effect is not yet established, although the importance of conveying this fact to the patient is questionable. Of greater certainty is that the same irresolution surrounds the mechanism of action of pharmaceutical antidepressants, and so a double standard in patient care should be mindfully avoided if provision of this information is deemed a prerequisite for proper 'informed' consent. PMID:24938322

Torrance, Robert

2015-05-01

87

Parents of deaf children with cochlear implants: a study of technology and community.  

PubMed

The cochlear implant (CI) is increasingly used to treat deafness, despite arguments from the deaf community. Deaf children born to hearing parents are the fastest growing group of CI recipients, making parents the primary consumers. Instead of focusing on the controversy over implants, this article examines the clinical structures shaping parental decision-making and how parents integrate clinical practices into family and community. Observations and in-depth interviews were conducted in a CI clinic and at various community sites. The data reveal strong inter-institutional co-operations between the clinic, the state and local school districts. Working together, these institutions anticipate parental needs, foster a CI community and thus increase compliance. I conclude that implantation is an ongoing practice enculturating parents into a new community characterised by the adoption of long-term rehabilitative duties. However, the long-term nature of rehabilitation creates disparities in outcomes, which would be better understood through further research on the social relations in families and across parent networks in the CI community. PMID:22026391

Mauldin, Laura

2012-05-01

88

The combination of digital surface scanners and cone beam computed tomography technology for guided implant surgery using 3Shape implant studio software: a case history report.  

PubMed

The incorporation of virtual engineering into dentistry and the digitization of information are providing new perspectives and innovative alternatives for dental treatment modalities. The use of digital surface scanners with surgical planning software allows for the combination of the radiographic, prosthetic, surgical, and laboratory fields under a common virtual scenario, permitting complete digital treatment planning. In this article, the authors present a clinical case in which a guided implant surgery was performed based on a complete digital surgical plan combining the information from a cone beam computed tomography scan and the virtual simulation obtained from the 3Shape TRIOS intraoral surface scanner. The information was imported to and combined in the 3Shape Implant Studio software for guided implant surgery planning. A surgical guide was obtained by a 3D printer, and the surgical procedure was done using the Biohorizons Guided Surgery Kit and its protocol. PMID:25822304

Lanis, Alejandro; Álvarez Del Canto, Orlando

2015-01-01

89

Implant Chips  

NSDL National Science Digital Library

A group of eight people, including all members of one Florida family, had an implant chip, roughly the size of a grain of rice, injected under their skin on Friday, May 10. Manufactured by Applied Digital Solutions (ADS), the chips store a special identification number that enables the retrieval of personal and medical information. In the event of a medical emergency, a special handheld scanner activates the dormant digital implant, which provides identification data with which medical personnel can query ADS's database, the location of the patient's medical records. Alzheimer's patients seem to be the most promising market for this technology, even though other people, like the Florida family, hope to benefit from it as well. Another product that ADS offers is called Digital Angel, a wearable global positioning system (GPS) device that, among other things, can track in real time the wearer's physical movements. In the future, ADS is planning to release a product that will utilize both of these technologies: an implanted GPS-enabled chip. Unlike VeriChip, though, the GPS-enabled implant would require Food and Drug Administration (FDA) approval, meaning the US market won't see its introduction until after FDA testing. Many organizations, ranging from privacy advocates to religious groups, have already denounced VeriChip and its eventually successors, associated them with "Big Brother" and the biblical "Mark of the Beast."To read about the eight people that received their implants, look at the first and second sites, articles from the Los Angeles Times and Miami Herald respectively. For a non-US perspective, view the news story posted by the British Broadcasting Company (BBC). The fourth site, an extensive analysis of the subject from ABC News, should give readers a broader understanding of implanted chips and their potential uses. Two sites from ADS are next -- VeriChip's product pages and the press release that details a FDA's decision regarding VeriChip in April, 2002. Finally, the last two sites give more information on Digital Angel and a sample of GPS technology already in use.

Schroeder, Ted.

2002-01-01

90

Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function  

NASA Astrophysics Data System (ADS)

Recently, carbon nanotubes together with other types of conductive materials have been used to enhance the viability and function of cardiomyocytes in vitro. Here we demonstrated a paradigm to construct ECTs for cardiac repair using conductive nanomaterials. Single walled carbon nanotubes (SWNTs) were incorporated into gelatin hydrogel scaffolds to construct three-dimensional ECTs. We found that SWNTs could provide cellular microenvironment in vitro favorable for cardiac contraction and the expression of electrochemical associated proteins. Upon implantation into the infarct hearts in rats, ECTs structurally integrated with the host myocardium, with different types of cells observed to mutually invade into implants and host tissues. The functional measurements showed that SWNTs were essential to improve the performance of ECTs in inhibiting pathological deterioration of myocardium. This work suggested that conductive nanomaterials hold therapeutic potential in engineering cardiac tissues to repair myocardial infarction.

Zhou, Jin; Chen, Jun; Sun, Hongyu; Qiu, Xiaozhong; Mou, Yongchao; Liu, Zhiqiang; Zhao, Yuwei; Li, Xia; Han, Yao; Duan, Cuimi; Tang, Rongyu; Wang, Chunlan; Zhong, Wen; Liu, Jie; Luo, Ying; (Mengqiu) Xing, Malcolm; Wang, Changyong

2014-01-01

91

Multichannel implantable telemetry system  

NASA Technical Reports Server (NTRS)

Multiplexed biotelemetry system for animal research combines several power-saving features. Implantable sensor measures up to eight parameters simultaneously, including blood flow. Microamp transistors, switching circuits, and CMOS technology are used to lower power requirements. However, when blood flow is monitored, these measures are insufficient to reduce power enough for long-term operation from implantable primary battery.

Fryer, T. B.; Mccutcheon, E. P.; Sandler, H.; Freund, W.

1977-01-01

92

The Effect of Technology and Testing Environment on Speech Perception using Telehealth with Cochlear Implant Recipients  

PubMed Central

Purpose The current study evaluated the effect of remote system and acoustic environment on speech perception via telehealth with cochlear implant recipients. Method Speech perception was measured in quiet and in noise. Systems evaluated were: Polycom visual concert (PVC) and a hybrid presentation system (HPS). Each system was evaluated in a sound-treated booth and a quiet office. Results For speech in quiet, there was a significant effect of environment with better performance in the booth compared to the office; there was no effect of system (PVC or HPS). Speech in noise revealed a significant interaction between environment and system. Subjects’ performance was poorer for PVC in the office while performance in the sound booth was not significantly different for the two systems. Results from the current study were compared to results for the same group of subjects from an earlier study; results suggested poorer performance at remote sites in the previous study was primarily due to environment, not system. Conclusions Speech perception was best when evaluated in a sound-treated booth. HPS was superior for speech in noise in a reverberant environment. Future research should focus on modifications to non sound-treated environments for telehealth service delivery in rural areas. PMID:22411283

Goehring, Jenny L.; Hughes, Michelle L.; Baudhuin, Jacquelyn L.; Valente, Daniel L.; McCreery, Ryan W.; Diaz, Gina R.; Sanford, Todd; Harpster, Roger

2012-01-01

93

State of the art of IT-based high precision patch/implant system technology development for building/large structure safety management in Korea  

NASA Astrophysics Data System (ADS)

Damage to infrastructure is a real concern at present, caused primarily by worldwide climate anomalies, global warming, and natural disasters. Korea has begun research to develop a high precision patch/implant system using new IT as a basis, as critical element in building/large structure safety management, to adjust to this situation. Technologies which must be developed for this research are those which measure and evaluate the soundness and safety of structures based on the measurements of an attached sensor. During the research period, optical fiber sensor patches and wireless sensor capsule implants along with various sensor technologies, stress sensing and structure condition evaluation technologies, high durability sensors and low-power compact smart structure sensors will be developed effectively for network hardware technologies. Similarly high precision image processing for automatic crack extraction will be developed along with radiation sensor application technologies, combined management/control technologies for development systems, and practical technologies for building/large structure development systems. Through the results, we hope to acquire higher sensor system performance with a measurement scope (for precision, etc.) goal at least 200% better than conventional sensor systems. The goal is to attain safety management planning and commercialization for automatic and high technology buildings/large structures. If such research is successfully developed, groundbreaking developments for maintenance related facilities is expected.

Park, Ki-Tae; Yu, Young-Jun; Lee, Bomi; Lee, Jin-Hyung

2012-04-01

94

Cochlear Implants.  

ERIC Educational Resources Information Center

This brochure explains what a cochlear implant is, lists the types of individuals with deafness who may be helped by a cochlear implant, describes the process of evaluating people for cochlear implants, discusses the surgical process for implanting the aid, traces the path of sound through the cochlear implant to the brain, notes the costs of…

Clark, Catherine; Scott, Larry

95

Semiconductor thin film transfer by wafer bonding and advanced ion implantation layer splitting technologies  

Microsoft Academic Search

Wafer bonding is an attractive technology for modern semiconductor and microelectronic industry due to its variability in allowing combination of materials. Initially, the bonding of wafers of the same material, such as silicon-silicon wafer bonding has been major interest. In the meantime, research interest has shifted to the bonding of dissimilar materials such as silicon to quartz or to sapphire.

Tien-Hsi Lee

1998-01-01

96

A novel root analogue dental implant using CT scan and CAD/CAM: selective laser melting technology.  

PubMed

Direct laser metal forming (DLMF) is a new technique which allows solids with complex geometry to be produced by annealing metal powder microparticles in a focused laser beam, according to a computer-generated three-dimensional (3D) model. For dental implants, the fabrication process involves the laser-induced fusion of titanium microparticles, in order to build, layer by layer, the desired object. Modern computed tomography (CT) acquisition and 3D image conversion, combined with the DLMF process, allows the fabrication of custom-made, root-analogue implants (RAI), perfect copies of the radicular units that need replacing. This report demonstrates the successful clinical use of a custom-made, root-analogue DLMF implant. CT images of the residual non-restorable root of a right maxillary premolar were acquired and modified with specific software into a 3D model. From this model, a custom-made, root-analogue, DLMF implant was fabricated. Immediately after tooth extraction, the root-analogue implant was placed in the extraction socket and restored with a single crown. At the 1-year follow-up examination, the custom-made implant showed almost perfect functional and aesthetic integration. The possibility of fabricating custom-made, root-analogue DLMF implants opens new interesting perspectives for immediate placement of dental implants. PMID:22377004

Figliuzzi, M; Mangano, F; Mangano, C

2012-07-01

97

Science and Technology of Bio-Inert Thin Films as Hermetic-Encapsulating Coatings for Implantable Biomedical Devices: Application to Implantable Microchip in the Eye for the Artificial Retina  

NASA Astrophysics Data System (ADS)

Extensive research has been devoted to the development of neuron prostheses and hybrid bionic systems to establish links between the nervous system and electronic or robotic prostheses with the main focus of restoring motor and sensory functions in blind patients. Artificial retinas, one type of neural prostheses we are currently working on, aim to restore some vision in blind patients caused by retinitis picmentosa or macular degeneration, and in the future to restore vision at the level of face recognition, if not more. Currently there is no hermetic microchip-size coating that provides a reliable, long-term (years) performance as encapsulating coating for the artificial retina Si microchip to be implanted inside the eye. This chapter focuses on the critical topics relevant to the development of a robust, long-term artificial retina device, namely the science and technology of hermetic bio-inert encapsulating coatings to protect a Si microchip implanted in the human eye from being attacked by chemicals existing in the eye's saline environment. The work discussed in this chapter is related to the development of a novel ultrananocrystalline diamond (UNCD) hermetic coating, which exhibited no degradation in rabbit eyes. The material synthesis, characterization, and electrochemical properties of these hermetic coatings are reviewed for application as encapsulating coating for the artificial retinal microchips implantable inside the human eye. Our work has shown that UNCD coatings may provide a reliable hermetic bio-inert coating technology for encapsulation of Si microchips implantable in the eye specifically and in the human body in general. Electrochemical tests of the UNCD films grown under CH4/Ar/H2 (1%) plasma exhibit the lowest leakage currents (˜7 × 10-7 A/cm2) in a saline solution simulating the eye environment. This leakage is incompatible with the functionality of the first-generation artificial retinal microchip. However, the growth of UNCD on top of the Si microchip passivated by a silicon nitride layer or the oxide layers is also under investigation in our group as introduced in this chapter. The electrochemically induced leakage will be reduced by at least one to three orders of magnitude to the range of 10-10 A/cm2, which is compatible with reliable, long-term implants.

Auciello, Orlando; Shi, Bing

98

189188 Master of Science in Informatics, Major in Applied Informatics 189 Basic Courses (30 ECTS)  

E-print Network

; Development Methodologies (Waterfall, Iterative, RUP, XP, Agile vs. Traditional); Software tools (30 ECTS) Algorithms and Complexity 6 Intelligent Systems 6 Software Engineering 6 Programming, Simulation and Optimisation 6 Software Quality 6 Advanced Data Management System 6 Laboratories (6 ECTS

Krause, Rolf

99

Optical absorption spectra and geometric e ects in higher fullerenes  

E-print Network

Optical absorption spectra and geometric e ects in higher fullerenes (Running head: Optical absorption in higher fullerenes) Kikuo Harigaya and Shuji Abe Physical Science Division, Electrotechnical of their amplitudes at the pentagons. The oscillator strengths of projected absorption almost accord with those

Harigaya, Kikuo

100

Microsoft Word - App 9-1 ECT Form.doc  

Cancer.gov

1 Lung Screening Study Version 3.0 Manual of Operations and Procedures 11/15/00 Appendix 9-1 Lung Screening Study RECORD OF EXPERIENCE, CREDENTIALS AND TRAINING (ECT) EXAMINER/TRAINER/QUALITY ASSURANCE EXAMINER/MEDICAL RECORDS ABSTRACTOR/NOSOLOGIST

101

Modulbezeichnung Lineare Algebra I ECTS-Punkte 9  

E-print Network

Modulbezeichnung Lineare Algebra I Modus ECTS-Punkte 9 Lehrform / SWS Vorlesung + Gro�e �bung Diagonalisierung, Euklidische Vektorräume Literatur 1.) G. Fischer: Lineare Algebra 2.) M. Koecher: Lineare Algebra Linearen Algebra, Kenntnis der wesentlichen mathematischen Beweismethoden. Inhalte Gruppen, Ringe, Körper

Mannheim, Universität

102

FIRST SEMESTER (25.5 ECTS) Leveling in Communication 3  

E-print Network

for Communication 3 SECOND SEMESTER (27 ECTS) Event Management 3 Tourism Planning and Development 3 Innovation TOURISM GOALS AND CONTENTS Having developed very rapidly in recent decades, interna- tional tourism has in Tourism Attractions and Events 1.5 Economics and Politics of International Tourism 4.5 International

Krause, Rolf

103

The Waters of Life: Electrostatic Solvation E ects in Proteins  

E-print Network

) Boundary element method 4 Electrostatic E ects in Proteins 4.1 Charge-Charge Interactions 4.2 Charge boundary and image charge (b) Born model (c) Kirkwood-Tanford model 3.3 Numeric Methods (a) Overview (b University To whom correspondence should be addressed 1 #12;1 Introduction 2. Basic Concepts and Elements 2

Weng, Zhiping

104

Dental Implant Systems  

PubMed Central

Among various dental materials and their successful applications, a dental implant is a good example of the integrated system of science and technology involved in multiple disciplines including surface chemistry and physics, biomechanics, from macro-scale to nano-scale manufacturing technologies and surface engineering. As many other dental materials and devices, there are crucial requirements taken upon on dental implants systems, since surface of dental implants is directly in contact with vital hard/soft tissue and is subjected to chemical as well as mechanical bio-environments. Such requirements should, at least, include biological compatibility, mechanical compatibility, and morphological compatibility to surrounding vital tissues. In this review, based on carefully selected about 500 published articles, these requirements plus MRI compatibility are firstly reviewed, followed by surface texturing methods in details. Normally dental implants are placed to lost tooth/teeth location(s) in adult patients whose skeleton and bony growth have already completed. However, there are some controversial issues for placing dental implants in growing patients. This point has been, in most of dental articles, overlooked. This review, therefore, throws a deliberate sight on this point. Concluding this review, we are proposing a novel implant system that integrates materials science and up-dated surface technology to improve dental implant systems exhibiting bio- and mechano-functionalities. PMID:20480036

Oshida, Yoshiki; Tuna, Elif B.; Aktören, Oya; Gençay, Koray

2010-01-01

105

Current trends in dental implants  

PubMed Central

Tooth loss is very a very common problem; therefore, the use of dental implants is also a common practice. Although research on dental implant designs, materials and techniques has increased in the past few years and is expected to expand in the future, there is still a lot of work involved in the use of better biomaterials, implant design, surface modification and functionalization of surfaces to improve the long-term outcomes of the treatment. This paper provides a brief history and evolution of dental implants. It also describes the types of implants that have been developed, and the parameters that are presently used in the design of dental implants. Finally, it describes the trends that are employed to improve dental implant surfaces, and current technologies used for the analysis and design of the implants. PMID:24868501

Gaviria, Laura; Salcido, John Paul; Guda, Teja

2014-01-01

106

The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation  

PubMed Central

Ect2, a Rho guanine nucleotide exchange factor (RhoGEF), is atypical among RhoGEFs in its predominantly nuclear localization in interphase cells. One current model suggests that Ect2 mislocalization drives cellular transformation by promoting aberrant activation of cytoplasmic Rho family GTPase substrates. However, in ovarian cancers, where Ect2 is both amplified and overexpressed at the mRNA level, we observed that the protein is highly expressed and predominantly nuclear and that nuclear but not cytoplasmic Ect2 increases with advanced disease. Knockdown of Ect2 in ovarian cancer cell lines impaired their anchorage-independent growth without affecting their growth on plastic. Restoration of Ect2 expression rescued the anchorage-independent growth defect, but not if either the DH catalytic domain or the nuclear localization sequences of Ect2 were mutated. These results suggested a novel mechanism whereby Ect2 could drive transformation in ovarian cancer cells by acting as a RhoGEF specifically within the nucleus. Interestingly, Ect2 had an intrinsically distinct GTPase specificity profile in the nucleus versus the cytoplasm. Nuclear Ect2 bound preferentially to Rac1, while cytoplasmic Ect2 bound to RhoA but not Rac. Consistent with nuclear activation of endogenous Rac, Ect2 overexpression was sufficient to recruit Rac effectors to the nucleus, a process that required a functional Ect2 catalytic domain. Furthermore, expression of active nuclearly targeted Rac1 rescued the defect in transformed growth caused by Ect2 knockdown. Our work suggests a novel mechanism of Ect2-driven transformation, identifies subcellular localization as a regulator of GEF specificity, and implicates activation of nuclear Rac1 in cellular transformation. PMID:24386507

Huff, Lauren P.; DeCristo, Molly J.; Trembath, Dimitri; Kuan, Pei Fen; Yim, Margaret; Liu, Jinsong; Cook, Danielle R.; Miller, C. Ryan; Der, Channing J.

2013-01-01

107

Water Splitting and Hydrogen Emitting Catalytic Function of Hydrogen-Implanted Oxide Ceramics Studied Using Ion Beam Technology  

SciTech Connect

Temperature dependence of the D-H replacement speed in D-implanted oxide ceramics exposed to H2O vapor has been studied using the ERD technique. It is found that the D-H replacement speed increases when the exposed specimen is heated above the implantation temperature and the amount of H uptaken by the D-H replacement is almost the same as the implantation amount of D, while both D as-implanted and H uptaken in the replacement are released by heating the specimen in the vacuum. No reduction in the amount of H uptaken by exposure to H2O vapor at elevated temperatures is ascribed to enough supply of H from the surface due to splitting of H2O faster than their thermal release. Based on the one way diffusion model of both dipole-induced water splitting at the surface and hydrogen gas emission from the bulk, it is shown that thermal detrapping of D implanted and H replaced in the specimen heated enhances the D-H replacement speed higher than the one extrapolated from the temperature dependence of the D-H replacement speed for the specimens cooled below the implantation temperature, in which the thermal detrapping hardly takes place.

Morita, K. [Department of General Education, Faculty of Science and Technology, Meijo University, 1-501 Shigamaguchi, Tenpaku-ku, Nagoya 468-8502 (Japan); Tsuchiya, B.; Nagata, S. [Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Katahira, K. [Advanced Research Institute for Materials, TYK Co. Ltd., Ohata-cho, Tajimi 507-8607 (Japan); Yoshino, M.; Yuhara, J. [Department of Quantum Science and Energy Engineering, Nagoya University, Furo-cho Chikusa-ku, 464-8603 (Japan); Arita, Y. [Institute for EcoTopia Science, Nagoya University, Furo-cho Chikusa-ku, 464-8603 (Japan); Ishijima, T.; Sugai, H. [Department of Electronic Engineering, Graduate School of Engineering, Nagoya University, Furo-cho Chikusa-ku, 464-8603 (Japan)

2006-11-13

108

New implant designs for fracture fixation in osteoporotic bone  

Microsoft Academic Search

Screws are one of the limiting factors for fixation of implants, particularly in poor bone quality. A class of new implants with an implant–bone–interface optimized regarding load transition by increasing the peripheral area might improve the anchorage of implants in osteoporotic bone. However, the shape of these implants requires new technologies for insertion. The goal of the work presented here

J. Goldhahn; J. Seebeck; R. Frei; B. Frenz; I. Antoniadis; E. Schneider

2005-01-01

109

Electroconvulsive therapy in the presence of deep brain stimulation implants: electric field effects.  

PubMed

The safety of electroconvulsive therapy (ECT) in patients who have deep brain stimulation (DBS) implants represents a significant clinical issue. A major safety concern is the presence of burr holes and electrode anchoring devices in the skull, which may alter the induced electric field distribution in the brain. We simulated the electric field using finite-element method in a five-shell spherical head model. Three DBS electrode anchoring techniques were modeled, including ring/cap, microplate, and burr-hole cover. ECT was modeled with bilateral (BL), right unilateral (RUL), and bifrontal (BF) electrode placements and with clinically-used stimulus current amplitude. We compared electric field strength and focality among the DBS implantation techniques and ECT electrode configurations. The simulation results show an increase in the electric field strength in the brain due to conduction through the burr holes, especially when the burr holes are not fitted with nonconductive caps. For typical burr hole placement for subthalamic nucleus DBS, the effect on the electric field strength and focality is strongest for BF ECT, which runs contrary to the belief that more anterior ECT electrode placements are safer in patients with DBS implants. PMID:21096149

Deng, Zhi-De; Hardesty, David E; Lisanby, Sarah H; Peterchev, Angel V

2010-01-01

110

Cochlear Implants  

MedlinePLUS

A cochlear implant is a small, complex electronic device that can help to provide a sense of sound. People who are ... of-hearing can get help from them. The implant consists of two parts. One part sits on ...

111

Carmustine Implant  

MedlinePLUS

Carmustine implant is used along with surgery and sometimes radiation therapy to treat malignant glioma (a certain type of ... Carmustine implant comes as a small wafer that is placed in the brain by a doctor during surgery to ...

112

Cochlear Implants  

MedlinePLUS

... the process Understand (when able), along with their parents, their role in the successful use of cochlear implants Have (when able), along with their parents, realistic expectations for cochlear implant use Are willing ...

113

Cochlear implant  

MedlinePLUS

... antenna. This part of the implant receives the sound, converts the sound into an electrical signal, and sends it to ... implants allow deaf people to receive and process sounds and speech. However, it is important to understand ...

114

Goserelin Implant  

MedlinePLUS

Goserelin implant is used in combination with radiation therapy and other medications to treat localized prostate cancer ... the treatment of abnormal bleeding of the uterus. Goserelin implant is in a class of medications called ...

115

Oral implants.  

PubMed

Today, more and more evidence suggests that even small changes in hardware for oral implants may jeopardize its biocompatibility. Even the manner in which the hardware is sterilized can influence cellular adhesion. This review discusses the surface characteristics, configuration, and success rates of various oral implants, as well as the complications that can result following implantation. PMID:1777657

van Steenberghe, D

1991-04-01

116

ASIC or PIC? Implantable stimulators based on semi-custom CMOS technology or low-power microcontroller architecture  

Microsoft Academic Search

To gain a better understanding of the effects of chronic stimulation on mammalian muscles we needed to generate patterns of greater variety and complexity than simple constant-frequency or burst patterns. We describe here two approaches to the design of implantable neuromuscular stimulators that can satisfy these requirements. Devices of both types were developed and used in long-term experiments. The first

S Salmons; G. T Gunning; I Taylor; S. R. W Grainger; D. J Hitchings; J Blackhurst; J. C Jarvis

2001-01-01

117

Superelastic Orthopedic Implant Coatings  

NASA Astrophysics Data System (ADS)

The demand for hip and knee replacement surgery is substantial and growing. Unfortunately, most joint replacement surgeries will fail within 10-25 years, thereby requiring an arduous, painful, and expensive revision surgery. To address this issue, a novel orthopedic implant coating material ("eXalt") has been developed. eXalt is comprised of super elastic nitinol wire that is knit into a three-dimensional spacer fabric structure. eXalt expands in vivo to conform to the implantation site and is porous to allow for bone ingrowth. The safety and efficacy of eXalt were evaluated through structural analysis, mechanical testing, and a rabbit implantation model. The results demonstrate that eXalt meets or exceeds the performance of current coating technologies with reduced micromotion, improved osseointegration, and stronger implant fixation in vivo.

Fournier, Eric; Devaney, Robert; Palmer, Matthew; Kramer, Joshua; El Khaja, Ragheb; Fonte, Matthew

2014-07-01

118

Up-regulation of ECT2 is associated with poor prognosisn gastric cancer patients  

PubMed Central

Objectives: The aim of this study was to investigate the expression of ECT2 in gastric cancer and its clinical significance. Methods and results: We investigated the differentially expressed genes between gastric cancer tissues and normal gastric mucosa by cDNA microarray, and then we found ECT2 was up-regulated in gastric cancer. What is more, we verified ECT2 expression level by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) and measured its protein level by immunohistochemistry (IHC). qRT-PCR analysis indicated ECT2 was significantly up-regulated in gastric cancer and Immunohistochemistry confirmed the percentage of ECT2-positive specimens was significantly higher in gastric carcinoma than in non-tumor tissues. Up-regulation of ECT2 is associated with the degree of histological differentiation (P = 0.007), invasion depth (P = 0.047), lymph node metastasis (P = 0.016), distant metastasis (P = 0.021) and TNM stage (P = 0.016), patients with up-regulated ECT2 had a lower overall survival rate (P = 0.000). Cox regression analysis revealed that up-regulation of ECT2 is an independent prognostic factor in gastric cancer patients (P = 0.012). Conclusion: Up-regulation of ECT2 might contribute to the progression of gastric carcinogenesis and may be a useful prognostic indicator in gastric cancer. PMID:25674238

Jin, Yi; Yu, Yuhui; Shao, Qinshu; Ma, Yingyu; Zhang, Ruxuan; Yao, Haibo; Xu, Yuan

2014-01-01

119

Unilateral and bilateral ECT: a study of memory disturbance and relief from depression  

PubMed Central

Fifty-one endogenous and reactive female depressives were given a course of either unilateral non-dominant, unilateral dominant, or bilateral ECT. Visual and verbal memory tests and confusion ratings were administered at frequent intervals during the treatment course. Pre-and post-treatment assessments of depression were made. Comparisons of the therapeutic effect of six and of eight ECTs were studied separately. One month after the last ECT the patients were again assessed on the memory and the depression tests. The results of the memory tests indicate that unilateral non-dominant ECT produced least memory disturbance (particularly of a verbal kind) and also less immediate confusion within 40 minutes of each ECT. This observation applies more to the reactive than the endogenous group. Comparisons of the depression tests reveal that unilateral non-dominant ECT is as effective in relieving depression as bilateral ECT, though progress may be less rapid. The observation holds true only for the reactive depressives. Endogenous depressives benefit more from bilateral ECT. Caution is advised against the administration of unilateral dominant ECT, since this group does not respond to treatment as well as the other two groups. Degree of improvement as a whole does not appear to be related to the degree of confusion experienced. The implications of these findings are discussed. PMID:5478954

Cronin, D.; Bodley, P.; Potts, L.; Mather, Marcia D.; Gardner, R. K.; Tobin, Jean C.

1970-01-01

120

Detection and Sizing of Defects in Structural Components of a Nuclear Power Plant by ECT  

SciTech Connect

In this paper, progress of ECT technique for inspection of stress corrosion cracks in a structural component of a nuclear power plant is reported. Access and scanning vehicle (robot), advanced probes for SG tube inspection, development and evaluation of new probes for welding joint, and ECT based crack sizing technique are described respectively. Based on these new techniques, it is clarified that ECT can play as a supplement of UT for the welding zone inspection. It is also proved in this work that new ECT sensors are efficient even for a stainless plate as thick as 15mm.

Chen Zhenmao; Miya, Kenzo [International Institute of Universality, 2-7-17 Ikenohata, Taito-ku, Tokyo, 110-0008 (Japan)

2005-04-09

121

Endodontic implants.  

PubMed

Endodontic implants were introduced back in 1960. Endodontic implants enjoyed few successes and many failures. Various reasons for failures include improper case selection, improper use of materials and sealers and poor preparation for implants. Proper case selection had given remarkable long-term success. Two different cases are being presented here, which have been treated successfully with endodontic implants and mineral trioxide aggregate Fillapex (Andreaus, Brazil), an MTA based sealer. We suggest that carefully selected cases can give a higher success rate and this method should be considered as one of the treatment modalities. PMID:25298723

Yadav, Rakesh K; Tikku, A P; Chandra, Anil; Wadhwani, K K; Ashutosh Kr; Singh, Mayank

2014-01-01

122

Endodontic implants  

PubMed Central

Endodontic implants were introduced back in 1960. Endodontic implants enjoyed few successes and many failures. Various reasons for failures include improper case selection, improper use of materials and sealers and poor preparation for implants. Proper case selection had given remarkable long-term success. Two different cases are being presented here, which have been treated successfully with endodontic implants and mineral trioxide aggregate Fillapex (Andreaus, Brazil), an MTA based sealer. We suggest that carefully selected cases can give a higher success rate and this method should be considered as one of the treatment modalities. PMID:25298723

Yadav, Rakesh K.; Tikku, A. P.; Chandra, Anil; Wadhwani, K. K.; Ashutosh kr; Singh, Mayank

2014-01-01

123

Preconditioned alternating projection algorithms for maximum a posteriori ECT reconstruction  

NASA Astrophysics Data System (ADS)

We propose a preconditioned alternating projection algorithm (PAPA) for solving the maximum a posteriori (MAP) emission computed tomography (ECT) reconstruction problem. Specifically, we formulate the reconstruction problem as a constrained convex optimization problem with the total variation (TV) regularization. We then characterize the solution of the constrained convex optimization problem and show that it satisfies a system of fixed-point equations defined in terms of two proximity operators raised from the convex functions that define the TV-norm and the constraint involved in the problem. The characterization (of the solution) via the proximity operators that define two projection operators naturally leads to an alternating projection algorithm for finding the solution. For efficient numerical computation, we introduce to the alternating projection algorithm a preconditioning matrix (the EM-preconditioner) for the dense system matrix involved in the optimization problem. We prove theoretically convergence of the PAPA. In numerical experiments, performance of our algorithms, with an appropriately selected preconditioning matrix, is compared with performance of the conventional MAP expectation-maximization (MAP-EM) algorithm with TV regularizer (EM-TV) and that of the recently developed nested EM-TV algorithm for ECT reconstruction. Based on the numerical experiments performed in this work, we observe that the alternating projection algorithm with the EM-preconditioner outperforms significantly the EM-TV in all aspects including the convergence speed, the noise in the reconstructed images and the image quality. It also outperforms the nested EM-TV in the convergence speed while providing comparable image quality.

Krol, Andrzej; Li, Si; Shen, Lixin; Xu, Yuesheng

2012-11-01

124

Ion implantation in semiconductors  

Microsoft Academic Search

Ion implantation is being applied extensively to silicon device technology. Two principle features are utilized- 1) charge control in MOS structures for threshold shift, autoregistration, and complementary wells and 2) distribution control in microwave and bipolar structures. Another feature that has not been extensively exploited is to combine the advantages of the high resolution capabilities of electric beam pattern delineation

James W. Mayer

1973-01-01

125

Histories of cochlear implantation  

Microsoft Academic Search

The cochlear implant, an electronic device by means of which some totally deaf people can be provided with a form of hearing, has been increasingly used since the early 1980s. The mass media have typically presented it as an example of the remarkable success of modern technological medicine. In France and the Netherlands, the countries on which this paper focuses,

Stuart S. Blume

1999-01-01

126

0.5 {mu}m E/D AlGaAs/GaAs heterostructure field effect transistor technology with DFET threshold adjust implant  

SciTech Connect

A doped-channel heterostructure field effect transistor (H-FET) technology has been developed with self-aligned refractory gate processing and using both enhancement- and depletion-mode transistors. D-HFET devices are obtained with a threshold voltage adjust implant into material designed for E-HFET operation. Both E- and D-HFETs utilize W/WSi bilayer gates, sidewall spacers, and rapid thermal annealing for controlling short channel effects. The 0.5 {mu}m E- HFETs (D-HFETs) have been demonstrated with transconductance of 425 mS/mm (265-310 mS/mm) and f{sub t} of 45-50 GHz. Ring oscillator gate delays of 19 ps with a power of 0.6 mW have been demonstrated using direct coupled FET logic. These results are comparable to previous doped-channel HFET devices and circuits fabricated by selective reactive ion etching rather than ion implantation for threshold voltage adjustment.

Baca, A.G.; Sherwin, M.E.; Zolper, J.C.; Shul, R.J.; Briggs, R.D.; Heise, J.A.; Robertson, P.J.; Hafich, M.F.

1997-04-01

127

[Integration of modern technologies in therapy of sarcomas of the pelvis. Computer-assisted hemipelvectomy and implantation of a "custom-made" Bonit gentamycin coated partial pelvic prosthesis].  

PubMed

The resection of primary malignancies in the pelvis is technically demanding as organs and structures are to be preserved and reconstruction of the defect as well as the postoperative function and rehabilitation are dependent on an optimal prosthesis. We present two patients with a sarcoma of the pelvis where for the first time a structured concept of technology integration led to a press-fit implantation of a hemipelvic prosthesis. This concept includes the design and production of a "custom-made" prosthesis as a hemipelvic substitute and the coating of this prosthesis with Bonit, a second-generation calcium phosphate, and gentamycin in watery solution. The tumor resection was done with computer-assisted surgery based on computed tomographies (CT) of the pelvis model done by rapid prototyping rather than on the CT of the patients' pelvis. With this procedure the presurgically simulated resection could be executed precisely with complete resection of the tumors and an accuracy which allowed an exact implantation of the prosthesis. The course was uneventful with primary healing and no sign of an infection or loosening after 6 months. PMID:14634740

Bastian, L; Hüfner, T; Mössinger, E; Geerling, J; Goesling, T; Busche, M; Kendoff, D; Bading, S; Rosenthal, H; Krettek, C

2003-11-01

128

The use of sintered metal filters in the study of ECT in transformer oils  

Microsoft Academic Search

The use of sintered metal filters in the investigation of electrostatic charging tendency (ECT) in transformer oils was examined. Tests were conducted on the recirculating ECT tester. The results of passing two different oils through 60-?m filters are presented. The results obtained with the recirculating tester are sufficiently encouraging to warrant further development

R. G. Heydon; J. Rungis; R. Sheehy

1992-01-01

129

Virtual positioning and shaping of source fields for ECT of tubes  

Microsoft Academic Search

Purpose – The purpose of this paper is to present a new approach to drive the excitation field sources in the eddy current testing (ECT) of tubular conductive structures. Design\\/methodology\\/approach – The magnetic field used for ECT is generated by pairs of counter-series connected coils, driven by AC currents. The phase and amplitude of the currents is electronically controlled in

Fabrizio Ferraioli; Alessandro Formisano; Raffaele Martone; Francesco Iacotucci

2010-01-01

130

Discriminating graviton exchange e ects from other new physics scenarios in e  

E-print Network

Discriminating graviton exchange e#11;ects from other new physics scenarios in e + e collisions P;ects of graviton exchange from other new physics in high energy e + e annihilation into fermion]; anomalous gauge boson couplings (AGC) [9]; virtual Kaluza{Klein (KK) graviton exchange in the context

131

LC-TH-2003-046 Discriminating graviton exchange e ects from other  

E-print Network

LC-TH-2003-046 Discriminating graviton exchange e#11;ects from other new physics scenarios in e + e the e#11;ects of graviton exchange from other new physics in high energy e + e annihilation into fermion]; anomalous gauge boson couplings (AGC) [9]; virtual Kaluza{Klein (KK) graviton exchange in the context

132

DIS[subscript 2]ECT: A Framework for Effective Inclusive Science Instruction  

ERIC Educational Resources Information Center

The purpose of this article is to provide special education and general education teachers a framework (DIS[subscript 2]ECT) for teaching science in inclusive settings. DIS2ECT stands for Design (Backwards); Individualization; Scaffolding and Strategies; Experiential learning; Cooperative Learning; and Teamwork. This framework was derived from our…

Spaulding, Lucinda S.; Flannagan, Jenny Sue

2012-01-01

133

Stuck on You: Chewing Gum Adherent to the Oral Airway in Electroconvulsive Therapy (ECT).  

PubMed

We present a case in which a piece of chewing gum was discovered adhering to the oral airway when it was removed after an ECT procedure. We suggest that careful examination of the patient's mouth for foreign objects be a standard part of the pre-ECT protocol. PMID:25268044

Kellner, Charles H; Bryson, Ethan O; Aloysi, Amy S; Pasculli, Rosa M; Briggs, Mimi C

2014-09-29

134

The E ect of Barriers on The Tidal Range in Yong Ming Tang  

E-print Network

interest in constructing tidal barrages, either to control the tide or to extract power. CorrespondinglyThe E ect of Barriers on The Tidal Range in Estuaries Yong Ming Tang Abstract Numerical simulations of the shallow water equations are used to study the e ect of topographic barriers on the tidal range

135

Modelling the e#ects of air pollution on health using Bayesian Dynamic Generalised Linear Models  

E-print Network

Modelling the e#ects of air pollution on health using Bayesian Dynamic Generalised Linear Models 1 Introduction The potential detrimental e#ects of ambient air pollution is a major issue in public (2004)). Large multi­city studies such as `Air pollution and health: a European approach' (APHEA

Bath, University of

136

Personality, A ect and Emotion Taxonomy for Socially Intelligent Christine L. Lisetti  

E-print Network

Focality: global Focality: discouragement frustration satisfaction happiness Facial Expression: happy/sad/.../neutral Agency: self/other/none Control: yes/no Certainty: probability dist. Facial Expression: happy and time (Mo at, 1997). A ect: A ect varies along two dimensions: (i) va- lence which can be positive

Lisetti, Christine

137

OIL IN THE OPEN WATER Oil in the open water may a ect the health of  

E-print Network

OIL IN THE OPEN WATER Oil in the open water may a ect the health of microscopic plants and animals. Far beneath the surface, corals and other deepwater communities might also be a ected. OIL AND HUMAN AND SEDIMENTS · Water quality surveys · Transect surveys to detect submerged oil · Oil plume modeling · Sediment

138

Using Problem Generators to Explore the E ects of Epistasis Kenneth A. De Jong  

E-print Network

Using Problem Generators to Explore the E ects of Epistasis Kenneth A. De Jong Computer Science generators. We then describe three genera- tors that can be used to study the e ects of epistasis of epistasis on simple GAs. 1 Introduction Although we have made signi cant progress in recent years

139

Detection and Sizing of Defects in Structural Components of a Nuclear Power Plant by ECT  

Microsoft Academic Search

In this paper, progress of ECT technique for inspection of stress corrosion cracks in a structural component of a nuclear power plant is reported. Access and scanning vehicle (robot), advanced probes for SG tube inspection, development and evaluation of new probes for welding joint, and ECT based crack sizing technique are described respectively. Based on these new techniques, it is

Zhenmao Chen; Kenzo Miya

2005-01-01

140

Urogynecologic Surgical Mesh Implants  

MedlinePLUS

... Medical Devices Products and Medical Procedures Implants and Prosthetics Urogynecologic Surgical Mesh Implants Urogynecologic Surgical Mesh Implants ... More in Products and Medical Procedures Implants and Prosthetics Urogynecologic Surgical Mesh Implants Pelvic Organ Prolapse (POP) ...

141

Is electroconvulsive therapy (ECT) ever ethically justified? If so, under what circumstances.  

PubMed

The debate about ECT in Ireland in recent times has been vibrant and often polarised. The uniqueness of the Irish situation is that the psychiatric profession is protected by legislation whereby ECT treatment can be authorized by two consultant psychiatrists without the consent of the patient. This paper will consider if ECT is ever ethically justified, and if so, under what circumstances. The proposal is to investigate ECT from an ethical perspective with reference to the UNESCO Universal Declaration on Bioethics and Human Rights. The enquiry will begin with an historical context to the origin and development of ECT as a treatment for severe mental illness. The application of various ethical principles will be considered in conjunction with the relevant literature before arriving at a conclusion. PMID:22797936

Stefanazzi, Mary

2013-03-01

142

Semiconductor Ion Implanters  

NASA Astrophysics Data System (ADS)

In 1953 the Raytheon CK722 transistor was priced at 7.60. Based upon this, an Intel Xeon Quad Core processor containing 820,000,000 transistors should list at 6.2 billion! Particle accelerator technology plays an important part in the remarkable story of why that Intel product can be purchased today for a few hundred dollars. Most people of the mid twentieth century would be astonished at the ubiquity of semiconductors in the products we now buy and use every day. Though relatively expensive in the nineteen fifties they now exist in a wide range of items from high-end multicore microprocessors like the Intel product to disposable items containing `only' hundreds or thousands like RFID chips and talking greeting cards. This historical development has been fueled by continuous advancement of the several individual technologies involved in the production of semiconductor devices including Ion Implantation and the charged particle beamlines at the heart of implant machines. In the course of its 40 year development, the worldwide implanter industry has reached annual sales levels around 2B, installed thousands of dedicated machines and directly employs thousands of workers. It represents in all these measures, as much and possibly more than any other industrial application of particle accelerator technology. This presentation discusses the history of implanter development. It touches on some of the people involved and on some of the developmental changes and challenges imposed as the requirements of the semiconductor industry evolved.

MacKinnon, Barry A.; Ruffell, John P.

2011-06-01

143

Semiconductor Ion Implanters  

SciTech Connect

In 1953 the Raytheon CK722 transistor was priced at $7.60. Based upon this, an Intel Xeon Quad Core processor containing 820,000,000 transistors should list at $6.2 billion. Particle accelerator technology plays an important part in the remarkable story of why that Intel product can be purchased today for a few hundred dollars. Most people of the mid twentieth century would be astonished at the ubiquity of semiconductors in the products we now buy and use every day. Though relatively expensive in the nineteen fifties they now exist in a wide range of items from high-end multicore microprocessors like the Intel product to disposable items containing 'only' hundreds or thousands like RFID chips and talking greeting cards. This historical development has been fueled by continuous advancement of the several individual technologies involved in the production of semiconductor devices including Ion Implantation and the charged particle beamlines at the heart of implant machines. In the course of its 40 year development, the worldwide implanter industry has reached annual sales levels around $2B, installed thousands of dedicated machines and directly employs thousands of workers. It represents in all these measures, as much and possibly more than any other industrial application of particle accelerator technology. This presentation discusses the history of implanter development. It touches on some of the people involved and on some of the developmental changes and challenges imposed as the requirements of the semiconductor industry evolved.

MacKinnon, Barry A. [Isys, 2727 Walsh Ave., Suite 103, Santa Clara, CA 95051 (United States); Ruffell, John P. [Group 3, LLC, Sunnyvale, CA 94086 (United States)

2011-06-01

144

Preconditioned Alternating Projection Algorithms for Maximum a Posteriori ECT Reconstruction  

PubMed Central

We propose a preconditioned alternating projection algorithm (PAPA) for solving the maximum a posteriori (MAP) emission computed tomography (ECT) reconstruction problem. Specifically, we formulate the reconstruction problem as a constrained convex optimization problem with the total variation (TV) regularization. We then characterize the solution of the constrained convex optimization problem and show that it satisfies a system of fixed-point equations defined in terms of two proximity operators raised from the convex functions that define the TV-norm and the constrain involved in the problem. The characterization (of the solution) via the proximity operators that define two projection operators naturally leads to an alternating projection algorithm for finding the solution. For efficient numerical computation, we introduce to the alternating projection algorithm a preconditioning matrix (the EM-preconditioner) for the dense system matrix involved in the optimization problem. We prove theoretically convergence of the preconditioned alternating projection algorithm. In numerical experiments, performance of our algorithms, with an appropriately selected preconditioning matrix, is compared with performance of the conventional MAP expectation-maximization (MAP-EM) algorithm with TV regularizer (EM-TV) and that of the recently developed nested EM-TV algorithm for ECT reconstruction. Based on the numerical experiments performed in this work, we observe that the alternating projection algorithm with the EM-preconditioner outperforms significantly the EM-TV in all aspects including the convergence speed, the noise in the reconstructed images and the image quality. It also outperforms the nested EM-TV in the convergence speed while providing comparable image quality. PMID:23271835

Krol, Andrzej; Li, Si; Shen, Lixin; Xu, Yuesheng

2012-01-01

145

Monitoreo a distancia de los dispositivos automáticos implantables cardiovasculares (marcapasos, desfibriladores automáticos implantables y resincronizadores cardiacos)  

Microsoft Academic Search

In the era of communication technology, new options are available to monitor patients with Automatic Implantable Cardiovascular Devices (AICD) implanted pacemaker (PM) and Automa- tic Implantable Defibrillators (AID) and Cardiac resynchronization system (CRS). Most compa- nies offer devices with wireless capabilities to communicate automatically with transmitters, allowing remote monitoring device. These systems are being widely used in USA for remote

Milton E Guevara-Valdivia

2010-01-01

146

A 45nm low power bulk technology featuring carbon co-implantation and laser anneal on 45°-rotated substrate  

Microsoft Academic Search

This paper presents a cost-effective low power 45 nm bulk technology platform, primarily designed to serve the wireless multimedia and consumer electronics need. This technology platform features carbon co-IIP in the nMOS halo, laser annealing scheme, stress liner on the 45°-rotated wafer () for process simplicity to achieve high device performance and low leakage together. Drive current as high as

J. Yuan; V. Chan; M. Eller; N. Rovedo; H. K. Lee; Y. Gao; V. Sardesai; N. Kanike; V. Vidya; O. Kwon; J. Yan; S. Fang; W. Wille; H. Wang; Y. T. Chow; R. Booth; T. Kebede; W. Clark; H. Mo; C. Ryou; J. Liang; J. H. Yang; C. W. Lai; S. S. Naragad; O. Gluschenkov; M. R. Visokay; C. Radens; S. Deshpande; H. Shang; Y. Li; N. Cave; J. Sudijono; J. Ku; R. Divakaruni

2008-01-01

147

Speech Understanding with a New Implant Technology: A Comparative Study with a New Nonskin Penetrating Baha System  

PubMed Central

Objective. To compare hearing and speech understanding between a new, nonskin penetrating Baha system (Baha Attract) to the current Baha system using a skin-penetrating abutment. Methods. Hearing and speech understanding were measured in 16 experienced Baha users. The transmission path via the abutment was compared to a simulated Baha Attract transmission path by attaching the implantable magnet to the abutment and then by adding a sample of artificial skin and the external parts of the Baha Attract system. Four different measurements were performed: bone conduction thresholds directly through the sound processor (BC Direct), aided sound field thresholds, aided speech understanding in quiet, and aided speech understanding in noise. Results. The simulated Baha Attract transmission path introduced an attenuation starting from approximately 5?dB at 1000?Hz, increasing to 20–25?dB above 6000?Hz. However, aided sound field threshold shows smaller differences and aided speech understanding in quiet and in noise does not differ significantly between the two transmission paths. Conclusion. The Baha Attract system transmission path introduces predominately high frequency attenuation. This attenuation can be partially compensated by adequate fitting of the speech processor. No significant decrease in speech understanding in either quiet or in noise was found. PMID:25140314

Caversaccio, Marco

2014-01-01

148

Implant-Associated Infection  

Microsoft Academic Search

\\u000a During the last 50 years, medical devices have gained growing importance (Darouiche 2004). On the one side, there is an increasing\\u000a need due to the higher median age of the population suffering from degenerative diseases. On the other side, technology evolved\\u000a and many functions can be replaced by novel medical devices, such as cochlear implants, brain stimulators, and ventricular\\u000a assist

Werner Zimmerli; Andrej Trampuz

149

Bioelectronics and Implanted Devices  

Microsoft Academic Search

The future may well involve the emergence of humans who are fundamentally coupled with bioelectronic devices, science fiction's\\u000a “cyborgs.” Revolutions in semiconductor devices, cognitive science, bioelectronics, nanotechnology and applied neural control\\u000a technologies are facilitating breakthroughs in hybrids of humans and machines. The interactions of increased computing power,\\u000a advances in prosthetic devices, artificial implants, and systems that blend electronic and biological

Ellen M. McGee

150

Innovative Regeneration Technology to Solve Peri-implantitis by Er:YAG Laser Based on the Microbiologic Diagnosis: A Case Series.  

PubMed

Peri-implantitis is an emerging problem, and corrective therapy requires a method for decontaminating the complex surface structure of the implant body and sterilizing the surrounding tissue. The erbium:yttrium-aluminum-garnet (Er:YAG) laser has proven to effectively allow tissue to regenerate when used for peri-implantitis. The power of the Er:YAG laser is absorbed by a water molecule; therefore, its target neither rises in temperature nor carbonizes. An antibacterial remedy based on the bacteriologic diagnosis, followed by debridement and sterilization of the implant surface and peri-implant tissues by Er:YAG laser is efficacious for peri-implantitis treatment. The aim of this report was to present the effectiveness of the Er:YAG laser for peri-implant bone regeneration. This case series of two patients showed that antibiotic therapy reduced the bacterial amount from the peri-implantitis sites significantly and that Er:YAG laser therapy, along with the bone augmentation, enhanced bone regeneration in the peri-implant bony defects. PMID:25734708

Yoshino, Toshiaki; Yamamoto, Atsuhiko; Ono, Yoshihiro

2015-01-01

151

Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT  

PubMed Central

Dementia-related behavioral disturbances are mostly treated with antipsychotics; however, the observed beneficial effects are modest and the risk of serious adverse effects high. We report the case of a 57-year-old woman with severe early-onset Alzheimer’s disease and severe agitation, whom we treated with electroconvulsive therapy (ECT). A significant clinical improvement was achieved over eight ECT sessions, which were tolerated well without cognitive worsening, and lasted approximately 3 months. Our case demonstrates the safe and effective use of ECT in pharmacotherapy-resistant severe agitation in Alzheimer’s disease. The risk–benefit profile of ECT for dementia-related agitation should be further investigated in clinical trials. PMID:25419138

Aksay, Suna Su; Hausner, Lucrezia; Frölich, Lutz; Sartorius, Alexander

2014-01-01

152

Further improving the cognitive effect profile of electroconvulsive therapy (ECT): the case for studying carbamylated erythropoietin.  

PubMed

Electroconvulsive therapy (ECT) remains the most effective acute treatment for severe depression and several other psychiatric illnesses. However, its use has been limited by concerns about cognitive adverse effects. ECT may cause temporary cognitive impairment in some patients, typically anterograde amnesia for 1-2 weeks after a course of treatment, and circumscribed retrograde amnesia. These cognitive effects largely disappear within days to weeks after treatment. Efforts to find a pharmacological agent to reduce the cognitive effects of ECT have largely been unsuccessful, with the possible exception of thyroid hormone. We review the literature on pharmacological attempts to attenuate ECT's cognitive effects, and propose a novel neuroprotective and neurotrophic agent, carbamylated erythropoietin (CEPO), for this indication. PMID:25649853

Kellner, C H; Adams, D A; Benferhat, A

2015-03-01

153

ECT in an Adolescent with Down Syndrome and Treatment-Refractory Major Depressive Disorder  

Microsoft Academic Search

The efficacy of electroconvulsive therapy (ECT) as a treatment for patients with major depressive disorder who are intolerant of or refractory to antidepressant medications is well known. This treatment may be overlooked in children and adolescents, and in those with developmental disabilities. The case report of a 15-year-old male with Down syndrome and treatment-refractory major depressive disorder who received ECT

Paula M. Gensheimer; Karen G. Meighen; Christopher J. McDougle

2002-01-01

154

Ion Implant  

NSDL National Science Digital Library

This website includes an animation which illustrates the ion implant process. Objective: Name the three common dopants used in implantation processes and explain the process of generating an ion beam from source to wafer. You can find this animation under the heading "Process & Equipment III." This simulation is from Module 026 of the Process & Equipment III Cluster of the MATEC Module Library (MML). To view other clusters or for more information about the MML visit http://matec.org/ps/library3/process_I.shtmlKey

155

The Radiation Belt Storm Probes (RBSP) Energetic Particle, Composition, and Thermal Plasma (ECT) Instrument Suite  

NASA Astrophysics Data System (ADS)

The Energetic particle, Composition, and Thermal plasma (ECT) instrument suite was selected recently by NASA as part of the Radiation Belt Storm Probe (RBSP) mission. In this presentation, we summarize the RBSP-ECT science investigation. The ECT suite contains a well-proven complement of particle instruments to ensure the highest quality measurements in the inner magnetosphere. The coordinated ECT particle measurements, analyzed in combination with fields and waves observations and state-of-the-art theory and modeling, are required for understanding the acceleration, global distribution, and variability of radiation belt electrons and ions, key science objectives of NASA's Living With a Star program and the RBSP mission. ECT has four science objectives, which consolidate the eight prioritized RBSP mission objectives. They are: (1) determine the physical processes that produce radiation belt enhancements; (2) determine the dominant mechanisms for relativistic electron loss; (3) determine how the inner magnetospheric plasma environment controls radiation belt acceleration/loss; and, (4) develop empirical and physical models for understanding/predicting radiation belt space weather effects. In this poster, we present an overview of the science and measurements goals of the ECT suite as well as the instruments required to achieve those goals.

Spence, H. E.; Kepko, E.; Reeves, G.; Funsten, H.; Thomsen, M.; Henderson, M.; Friedl, R.; Skoug, R.; Jordanova, V.; Fennell, J.; Blake, J. B.; Clemmons, J.; O'Brien, T.; Green, J.; Onsager, T.; Elkington, S.; Baker, D.; Li, X.; Goldstein, J.; Young, D.; Jahn, J.; Thorne, R.; Hudson, M.; Horne, R.; Bourdarie, S.; Mann, I.

2006-12-01

156

Focus on ECT seizure quality: serum BDNF as a peripheral biomarker in depressed patients.  

PubMed

Electroconvulsive therapy (ECT) is a well-established, safe and effective treatment in severest or drug-resistant affective disorders. The potential relation between any peripheral biological marker and the seizure quality as a surrogate for treatment efficacy has not been investigated so far. We prospectively examined serum brain-derived neurotrophic factor (BDNF) levels in 20 patients with major depression before and after electroconvulsive therapy. A seizure quality sum score for every ECT session was build up on the basis of the seizure duration, seizure amplitude, central inhibition, interhemispheric coherence and sympathetic activation. Serum BDNF levels were significantly higher after ECT (P = 0.036). In the linear regression analysis, a significant correlation of the serum BDNF levels and the time between the last ECT and the blood withdrawal (P = 0.01) was observed. The ANOVA revealed a significant influence of the interval between the last ECT and the blood withdrawal (P = 0.0017) as well as the seizure quality (P = 0.038) on the variance of BDNF serum levels. Our data corroborate the neurotrophin hypothesis suggesting an ECT-induced central BDNF rise leading to a delayed (>6 days) and increased equilibrium of the peripheral BDNF. The association of seizure adequacy with a BDNF rise might underline the importance of monitoring seizure quality markers in daily practice. PMID:25231834

Bumb, Jan Malte; Aksay, Suna Su; Janke, Christoph; Kranaster, Laura; Geisel, Olga; Gass, Peter; Hellweg, Rainer; Sartorius, Alexander

2015-04-01

157

Dealing with moral dilemma raised by adaptive preferences in health technology assessment: the example of growth hormones and bilateral cochlear implants.  

PubMed

The aim of this article is to assess dilemma raised by adaptive preferences in the economic evaluation of growth hormone (GH) treatment for non-GH-deficient short children, and of bilateral cochlear implants for deaf children. Early implementation of both technologies and their irreversible consequences increase the potential conflicts faced by the assessors of health-related quality of life (HRQoL) states (on behalf of patients) who could be interviewed (parents, individuals with an experience of the same disability, or representative samples of the general public). Indeed, assessors' preferences may be influenced by their own situation and they are likely to vary according to age and the experience of disability. Three options are put forward which aim to resolve these moral dilemma and help economists make methodological choices that cannot be avoided in order to carry out this assessment. They are grounded on three specific egalitarian theories of social justice. The main contribution of this article is to show that a dialogue between ethics and economics, prior to an assessment, makes it possible to redefine the choice of effectiveness criteria (subjective well-being, capabilities or social outcomes), the choice of perspective (patients or the able-bodied), as well as the scope of assessment (medical and non-medical care). PMID:24355476

Thébaut, Clémence

2013-12-01

158

Ion implanted devices in silicon on sapphire  

Microsoft Academic Search

The fabrication of high-speed devices with low power dissipation by the use of silicon-on-sapphire and ion implantation technologies is reported. Ion-implanted resistors, diodes, and transistors can be made in silicon on sapphire. Using either implanted resistors or epitaxial resistors in the starting material, resistance values between several hundred ohms to several megaohms for integrated circuits can be obtained by the

S. Peterstrom; G. Holmen

1980-01-01

159

Sub-2y node NAND flash characteristics using spot beam technology for low energy, high tilt implant for n-poly doping  

NASA Astrophysics Data System (ADS)

Reduction of polysilicon sheet resistivity and polysilicon depletion ratio (PDR) are two major challenges for improving the memory cell characteristics of sub-20 nm NAND Flash devices. High phosphorus doses are implanted into in situ doped polysilicon floating gates to improve PDR, but phosphorus concentrations that are too high can degrade cell characteristics by increasing trapped charge in the TNOX(Tunnel Oxide). It is also important to prevent the bending of narrow polysilicon lines during floating gate implantation. We explored various conditions of low energy, high tilt phosphorus implants for floating gate doping using a spot beam high current implanter. The optimal concentration of implant energy, tilt angle, and thermal annealing has been shown to improve PDR and floating gate TOP CD control.

Ryu, Chong-Il; Lee, Sangsun; Jeon, Young-Ho; Cheon, Youngil; Choi, Jin-Kwan; Yang, Young-Ho; Lee, Kyung-Won; Hong, Rympyo; Yoon, Jong-Yoon; Reece, Ron; Rubin, Leonard M.

2012-11-01

160

Cochlear Implants  

MedlinePLUS

... during an optimal period to develop speech and language skills. A growing body of research, much of it funded by the NIDCD, has shown that when these children receive a cochlear implant ... a young age develop language skills at a rate comparable to children with ...

161

Computerized implant-dentistry: Advances toward automation.  

PubMed

Advancements in the field of implantology such as three-dimensional imaging, implant-planning software, computer-aided-design/computer-aided-manufacturing (CAD/CAM) technology, computer-guided, and navigated implant surgery have led to the computerization of implant-dentistry. This three-dimensional computer-generated implant-planning and surgery has not only enabled accurate preoperative evaluation of the anatomic limitations but has also facilitated preoperative planning of implant positions along with virtual implant placement and subsequently transferring the virtual treatment plans onto the surgical phase via static (guided) or dynamic (navigated) systems aided by CAD/CAM technology. Computerized-implant-dentistry being highly predictable and minimally invasive in nature has also allowed implant placement in patients with medical comorbidities (e.g. radiation therapy, blood dyscrasias), in patients with complex problems following a significant alteration of the bony anatomy as a result of benign or malignant pathology of the jaws or trauma and in patients with other physical and emotional problems. With significant achievements accomplished in the field of computerized implant-dentistry, attempts are now been made toward complete automation of implant-dentistry. PMID:25810585

Gulati, Minkle; Anand, Vishal; Salaria, Sanjeev Kumar; Jain, Nikil; Gupta, Shilpi

2015-01-01

162

Computerized implant-dentistry: Advances toward automation  

PubMed Central

Advancements in the field of implantology such as three-dimensional imaging, implant-planning software, computer-aided-design/computer-aided-manufacturing (CAD/CAM) technology, computer-guided, and navigated implant surgery have led to the computerization of implant-dentistry. This three-dimensional computer-generated implant-planning and surgery has not only enabled accurate preoperative evaluation of the anatomic limitations but has also facilitated preoperative planning of implant positions along with virtual implant placement and subsequently transferring the virtual treatment plans onto the surgical phase via static (guided) or dynamic (navigated) systems aided by CAD/CAM technology. Computerized-implant-dentistry being highly predictable and minimally invasive in nature has also allowed implant placement in patients with medical comorbidities (e.g. radiation therapy, blood dyscrasias), in patients with complex problems following a significant alteration of the bony anatomy as a result of benign or malignant pathology of the jaws or trauma and in patients with other physical and emotional problems. With significant achievements accomplished in the field of computerized implant-dentistry, attempts are now been made toward complete automation of implant-dentistry.

Gulati, Minkle; Anand, Vishal; Salaria, Sanjeev Kumar; Jain, Nikil; Gupta, Shilpi

2015-01-01

163

[Maintenance care for dental implant].  

PubMed

Dental implant has tried at the early stage in 19th century recovering an oral function and esthetics. Technological revolutions in biochemical and new materials have developed on the remarkable change in the dental implants, nowadays we call the three generation therapy for dental implantology. There are many kinds of methods and techniques in dental implants, however a lot of troublesome complication on the process of surgical phase, construction of prothodontics and prognosis of maintenance care. In the proceedings of this symposium, I would like to propose you how to manage the maintenance care for various kind of dental implants through the methodology and case presentations. Tendenay and future for dental implants The current outlook of dental implant has increasing supply and demand not only dentists but also patients. According to Japanese Welfare Ministry's report in 1987, average missing teeth over sixty years old generations are approximately 42% in accordance with NIDR (U.S.A.) research. They are missed on ten over teeth in full 28th teeth dentitions owing to dental caries and periodontal diseases. Generally speaking, latent implant patients are occupied on the same possibility of needs for dental implants both Japan and U.S.A. Management of maintenance care The patients hardly recognized the importance of plaque control for the maintenance care in the intraoral condition after implantation. Dentists and dental staffs must be instruct patients for importance of plaque removal and control, because they already had forgotten the habit of teeth cleaning, especially in the edenturous conditions. 1) Concept of establishment in oral hygiene. Motivation and instruction for patients include very important factors in dental implants as well as in periodontal diseases. Patients who could not achieve on good oral hygiene levels obtained no good results in the long term observations. To establish good oral hygiene are how to control supra plaque surrounding tissues with patient himself. Ultimate concept of implantology have supported common concordance with periodontal therapy. 2) Patients consent and co-operation the right of informed consent, agreement to treatment by the patient has been gaining increased importance to implantology. Even the patient has consent, they must co-operate the process of dental implant with co-therapist (Fig. 2). 3) The clinical examination of clinical parameters in dental implants. (1) Plaque Index (Silness & Loe 1964) and Plaque Control Record (0 Leary 1978) (Table 5). (2) Gingival inflammation (Fig. 3). Ordinarlly, Gingival Bleeding Index (GBI Ainamo & Bay 1975) and Papilla Bleeding Index (Saxer & Jühlemann 1975) are used. (3) The depth of peri-implant sulcus with the plastic probe. (NDU style) (Fig. 4).(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2489287

Kamoi, K

1989-10-01

164

An Anillin-Ect2 Complex Stabilizes Central Spindle Microtubules at the Cortex during Cytokinesis  

PubMed Central

Cytokinesis occurs due to the RhoA-dependent ingression of an actomyosin ring. During anaphase, the Rho GEF (guanine nucleotide exchange factor) Ect2 is recruited to the central spindle via its interaction with MgcRacGAP/Cyk-4, and activates RhoA in the central plane of the cell. Ect2 also localizes to the cortex, where it has access to RhoA. The N-terminus of Ect2 binds to Cyk-4, and the C-terminus contains conserved DH (Dbl homologous) and PH (Pleckstrin Homology) domains with GEF activity. The PH domain is required for Ect2's cortical localization, but its molecular function is not known. In cultured human cells, we found that the PH domain interacts with anillin, a contractile ring protein that scaffolds actin and myosin and interacts with RhoA. The anillin-Ect2 interaction may require Ect2's association with lipids, since a novel mutation in the PH domain, which disrupts phospholipid association, weakens their interaction. An anillin-RacGAP50C (homologue of Cyk-4) complex was previously described in Drosophila, which may crosslink the central spindle to the cortex to stabilize the position of the contractile ring. Our data supports an analogous function for the anillin-Ect2 complex in human cells and one hypothesis is that this complex has functionally replaced the Drosophila anillin-RacGAP50C complex. Complexes between central spindle proteins and cortical proteins could regulate the position of the contractile ring by stabilizing microtubule-cortical interactions at the division plane to ensure the generation of active RhoA in a discrete zone. PMID:22514687

Frenette, Paul; Haines, Eric; Loloyan, Michael; Kinal, Mena; Pakarian, Paknoosh; Piekny, Alisa

2012-01-01

165

Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4.  

PubMed

Homo sapiens ECT2 is a cell cycle regulator that plays critical roles in cytokinesis. ECT2 activity is restrained during interphase via intra-molecular interactions that involve its N-terminal triple-BRCT-domain and its C-terminal DH-PH domain. At anaphase, this self-inhibitory mechanism is relieved by Plk1-phosphorylated CYK-4, which directly engages the ECT2 BRCT domain. To provide a structural perspective for this auto-inhibitory property, we solved the crystal structure of the ECT2 triple-BRCT-domain. In addition, we systematically analyzed the interaction between the ECT2 BRCT domains with phospho-peptides derived from its binding partner CYK-4, and have identified Ser164 as the major phospho-residue that links CYK-4 to the second ECT2 BRCT domain. PMID:25068414

Zou, Yang; Shao, Zhenhua; Peng, Junhui; Li, Fudong; Gong, Deshun; Wang, Chongyuan; Zuo, Xiaobing; Zhang, Zhiyong; Wu, Jihui; Shi, Yunyu; Gong, Qingguo

2014-08-25

166

Electronic Communications Technologies and the Transition to College: Links to Parent-Child Attachment and Adjustment  

ERIC Educational Resources Information Center

Electronic communications technologies (ECTs) help college students and parents remain in contact. Because recent reports have emphasized a link between ECTs, helicopter parenting, and autonomy issues, this study focused on the significance of contact patterns for attachment and student adjustment. First-semester college students (199 female, 81…

Sarigiani, Pamela A.; Trumbell, Jill M.; Camarena, Phame M.

2013-01-01

167

Information Technology for Workplace Communication. Workscape 21: The Ecology of New Ways of Working.  

ERIC Educational Resources Information Center

A study was undertaken to understand the role of electronic communication technologies (ECTs) in maintaining work-related communication. The study site was Sun Microsystems, a company at the high end of the curve in terms of its commitment to and employees' experience with ECTs. An electronic focus group (n=40, 4% response) and an e-mail survey…

Becker, Franklin; Tennessen, Carolyn M.; Young, David

168

Letter to the editor: The effect of ECT on sleep--a comment to Winkler et al.  

PubMed

Recent publications in this journal have suggested that successful electroconvulsive therapy (ECT) in depressed patients is associated with a phase advance, similar to what has been reported with antidepressant medications. Herein we review the effects of ECT on polysomnographic (PSG) sleep, and we conclude with the observation that ECT reliably increases PSG total sleep time and probably has a suppressive effect on rapid eye movement (REM) sleep. Remarkably, there is less information available on the topic of the effect of ECT on the patient's perception of their sleep. PMID:25434521

McCall, W Vaughn; Rosenquist, Peter B

2015-02-01

169

Application of the finite element method in dental implant research  

Microsoft Academic Search

This article provides a review of the achievements and advancements in dental technology brought about by computer-aided design and the all powerful finite element method (FEM) of analysis. The scope of the review covers dental implants, jawbone surrounding the implant and the biomechanical implant and jawbone interaction. Prevailing assumptions made in the published finite element analysis (FEA) and their limitations

R. C. Van Staden; H. Guan; Y. C. Loo

2006-01-01

170

Students’ Factors Affecting Undergraduates’ Perceptions of their Teaching and Learning Process within ECTS Experience  

PubMed Central

Introduction: In the present study, we investigated the potential factors that influenced the level of students satisfaction with the teaching–learning process (TLP), from the perspective of students participating in the European Credit Transfer System (ECTS) experience. Method: A total of 1490 students from the Universities of Almería and Granada (Spain) participated in an evaluation of their class discipline area. They completed the new revised protocol for evaluating the ECTS experience. Analyses of variance were carried out, taking the following factors as independent variables: student's grade average, year in school, study discipline, credit load in terms of ECTS credits assigned to a subject, the e-learning approach. Perception of the TLP was used as the dependent variable. Results: The data analyses showed variability of the degree of statistically significance among the factors that influenced students’ perceptions of the TLP. These factors included: Student's grade average (in favor of high performers), year in school (in favor of earlier years), ECTS load (in favor of subjects with a medium load of credits), and e-learning (in favor of its use). These research findings provided evidence to explore the delineation of a potential profile of factors that trigger a favorable perception of the TLP. Discussion and Conclusion: The present findings certainly have implications to deepen our understanding of the core beliefs, commitment, and the experience in shaping the implementation of the European Higher Education Area through the ECTS. PMID:21713171

la Fuente, Jesús De; Cardelle-Elawar, María; Peralta, F. Javier; Sánchez, M. Dolores; Martínez-Vicente, José Manuel; Zapata, Lucía

2010-01-01

171

Photobiomodulation and implants: implications for dentistry  

PubMed Central

The use of dental implants has become a mainstay of rehabilitative and restorative dentistry. With an impressive clinical success rate, there remain a few minor clinical issues with the use of implants such as peri-implant mucositis and peri-implantitis. The use of laser technology with implants has a fascinating breadth of applications, beginning from their precision manufacturing to clinical uses for surgical site preparation, reducing pain and inflammation, and promoting osseointegration and tissue regeneration. This latter aspect is the focus of this review, which outlines various studies of implants and laser therapy in animal models. The use of low level light therapy or photobiomodulation has demonstrated its efficacy in these studies. Besides more research studies to understand its molecular mechanisms, significant efforts are needed to standardize the clinical dosing and delivery protocols for laser therapy to ensure the maximal efficacy and safety of this potent clinical tool for photobiomodulation. PMID:24455438

Tang, Elieza

2013-01-01

172

Photobiomodulation and implants: implications for dentistry.  

PubMed

The use of dental implants has become a mainstay of rehabilitative and restorative dentistry. With an impressive clinical success rate, there remain a few minor clinical issues with the use of implants such as peri-implant mucositis and peri-implantitis. The use of laser technology with implants has a fascinating breadth of applications, beginning from their precision manufacturing to clinical uses for surgical site preparation, reducing pain and inflammation, and promoting osseointegration and tissue regeneration. This latter aspect is the focus of this review, which outlines various studies of implants and laser therapy in animal models. The use of low level light therapy or photobiomodulation has demonstrated its efficacy in these studies. Besides more research studies to understand its molecular mechanisms, significant efforts are needed to standardize the clinical dosing and delivery protocols for laser therapy to ensure the maximal efficacy and safety of this potent clinical tool for photobiomodulation. PMID:24455438

Tang, Elieza; Arany, Praveen

2013-12-01

173

Vanishing Electronic Medical Implants  

NSDL National Science Digital Library

Scientists have developed a new class of electronics capable of degrading into their environment. Unlike todayâ??s electronic devices, which are designed to last forever, the transient circuits developed by Suk-Won Hwang and colleagues disappear after a programmed amount of time. The technology could be useful in biomedical implants to help treat surgical infections or stimulate bone growth. The researchers crafted electronic circuits from cocoon silk, thin sheets of porous silicon and magnesium electrodes -- materials all capable of disappearing or resorbing into their environment.

Nadia Ramlagan (Science; )

2012-09-28

174

Historical development of active middle ear implants.  

PubMed

Active middle ear implants (AMEIs) are sophisticated technologies designed to overcome many of the shortcomings of conventional hearing aids, including feedback, distortion, and occlusion effect. Three AMEIs are currently approved by the US Food and Drug Administration for implantation in patients with sensorineural hearing loss. In this article, the history of AMEI technologies is reviewed, individual component development is outlined, past and current implant systems are described, and design and implementation successes and dead ends are highlighted. Past and ongoing challenges facing AMEI development are reviewed. PMID:25282038

Carlson, Matthew L; Pelosi, Stanley; Haynes, David S

2014-12-01

175

Appraisal of evidence base for introduction of new implants in hip and knee replacement: a systematic review of five widely used device technologies  

PubMed Central

Objective To determine the evidence of effectiveness and safety for introduction of five recent and ostensibly high value implantable devices in major joint replacement to illustrate the need for change and inform guidance on evidence based introduction of new implants into healthcare. Design Systematic review of clinical trials, comparative observational studies, and registries for comparative effectiveness and safety of five implantable device innovations. Data sources PubMed (Medline), Embase, Web of Science, Cochrane, CINAHL, reference lists of articles, annual reports of major registries, summaries of safety and effectiveness for pre-market application and mandated post-market studies at the US Food and Drug Administration. Study selection The five selected innovations comprised three in total hip replacement (ceramic-on-ceramic bearings, modular femoral necks, and uncemented monoblock cups) and two in total knee replacement (high flexion knee replacement and gender specific knee replacement). All clinical studies of primary total hip or knee replacement for symptomatic osteoarthritis in adults that compared at least one of the clinical outcomes of interest (patient centred outcomes or complications, or both) in the new implant group and control implant group were considered. Data searching, abstraction, and analysis were independently performed and confirmed by at least two authors. Quantitative data syntheses were performed when feasible. Results After assessment of 10?557 search hits, 118 studies (94 unique study cohorts) met the inclusion criteria and reported data related to 15?384 implants in 13?164 patients. Comparative evidence per device innovation varied from four low to moderate quality retrospective studies (modular femoral necks) to 56 studies of varying quality including seven high quality (randomised) studies (high flexion knee replacement). None of the five device innovations was found to improve functional or patient reported outcomes. National registries reported two to 12 year follow-up for revision occurrence related to more than 200?000 of these implants. Reported comparative data with well established alternative devices (over 1?200?000 implants) did not show improved device survival. Moreover, we found higher revision occurrence associated with modular femoral necks (hazard ratio 1.9) and ceramic-on-ceramic bearings (hazard ratio 1.0-1.6) in hip replacement and with high flexion knee implants (hazard ratio 1.0-1.8). Conclusion We did not find convincing high quality evidence supporting the use of five substantial, well known, and already implemented device innovations in orthopaedics. Moreover, existing devices may be safer to use in total hip or knee replacement. Improved regulation and professional society oversight are necessary to prevent patients from being further exposed to these and future innovations introduced without proper evidence of improved clinical efficacy and safety. PMID:25208953

Nieuwenhuijse, Marc J; Nelissen, R G H H; Schoones, J W

2014-01-01

176

The role of APOE-?4 and beta amyloid in the differential rate of recovery from ECT: a review.  

PubMed

Individual biological differences may contribute to the variability of outcomes, including cognitive effects, observed following electroconvulsive treatment (ECT). A narrative review of the research literature on carriage of the apolipoprotein E ?4 allele (APOE-?4) and the protein biomarker beta amyloid (A?) with ECT cognitive outcome was undertaken. ECT induces repeated brain seizures and there is debate as to whether this causes brain injury and long-term cognitive disruption. The majority of ECT is administered to the elderly (over age 65 years) with drug-resistant depression. Depression in the elderly may be a symptom of the prodromal stage of Alzheimer's disease (AD). Carriage of the APOE-?4 allele and raised cerebral A? are consistently implicated in AD, but inconsistently implicated in brain injury (and related syndromes) recovery rates. A paucity of brain-related recovery, genetic and biomarker research in ECT responses in the elderly was found: three studies have examined the effect of APOE-?4 allele carriage on cognition in the depressed elderly receiving ECT, and two have examined A? changes after ECT, with contradictory findings. Cognitive changes in all studies of ECT effects were measured by a variety of psychological tests, making comparisons of such changes between studies problematic. Further, psychological test data-validity measures were not routinely administered, counter to current testing recommendations. The methodological issues of the currently available literature as well as the need for well-designed, hypothesis driven, longitudinal studies are discussed. PMID:25826114

Sutton, T A; Sohrabi, H R; Rainey-Smith, S R; Bird, S M; Weinborn, M; Martins, R N

2015-01-01

177

ePUB: Modellierung Molecular Life Sciences Master Major 90 ECTS-Credits with special qualification in Plant Physiology  

E-print Network

Plant Biology: Plant Molecular Biology (lecture) (1.50 ECTS) (Wahlpflichtprüfung) (WS06/07 bis FS10) Advanced Plant Biology: Plant Molecular Biology / Pflanzenbiologie für Fortgeschrittene: Pflanzliche Molekularbiologie (1.50 ECTS) (Wahlpflichtprüfung) (ab HS10) Advanced Plant Biology: Plant Molecular Biology

Richner, Heinz

178

ImplantsHydroxylapatite coated dental implants  

Microsoft Academic Search

Objective To evaluate the clinical effectiveness, common complications and maintenance associated with hydroxylapatite (HA) coated cylindrical implants when used to support single crowns.Design A prospective medium term clinical study of the Calcitek HA-coated implant.Setting Implant placement, crown fabrication and follow-up procedures were carried out at the Leeds Dental Institute, between 1990 and 1998.Subjects and method 26 patients (33 implants) participated

Peter Briggs

1999-01-01

179

Top Ten Reasons a Graduate Student Should Apply to Be an ECT Foundation Intern  

ERIC Educational Resources Information Center

In this article, the author encourages graduate students to apply for the ECT Foundation Internship. She presents a list of the top ten benefits the internship offers a graduate student's career: (1) It could change your life. It changed mine; (2) Networking; (3) Mentoring; (4) Leadership opportunities; (5) Behind the scenes pass; (6) Shadowing;…

York, Cindy S.

2009-01-01

180

The E ect of Correlating Quantum Allocation and Job Size for Gang Scheduling ?  

E-print Network

The E ect of Correlating Quantum Allocation and Job Size for Gang Scheduling ? Gaurav Ghare Scott T,leutg@cs.du.edu Abstract. Gang scheduling is an e ective scheduling policy for multi- processing workloads with signi cant has generalized and re ned the coscheduling (now often called gang scheduling) concept 5,6,8,9,11, 14

Feitelson, Dror

181

E?ect of Soil Physical Factors on Methyl Iodide and Methyl Bromide  

Microsoft Academic Search

Production and importation of methyl bromide is scheduled to be banned by 2001. Methyl iodide was evaluated as a possible replacement soil fumigant. The e†ects of soil moisture, temperature, soil texture and fumigation time on the efficacy of methyl iodide for the control of two common weeds, Abutilon theophrasti and L olium multiÑorum, were characterized and compared with those of

Wenming Zhang; J. Ole Becker; Howard D. Ohr; James J. Sims; Steven D. Campbell

1998-01-01

182

Detecting Pulsatile Hormone Secretions Using Nonlinear Mixed E#ects Partial Spline Models  

E-print Network

Detecting Pulsatile Hormone Secretions Using Nonlinear Mixed E#ects Partial Spline Models Yu signaling. The identification of episodic releases of hormonal pulse signals constitutes a major emphasis hormone concentration measurements is of critical importance in endocrinology. In this paper, we propose

Wang, Yuedong

183

Adaptive modeling of environmental e ects in modal parameters for damage detection in civil structures  

E-print Network

to the structural temperature based on the vibration tests of ve bridges in the United Kingdom. Analyses based, boundary conditions, temperature, and humidity. Data from real bridge structures indicate that the e ects. Data from the Alamosa Canyon Bridge in the state of New Mexico were used to demonstrate the e

Stanford University

184

FIRST SEMESTER (27.5 ECTS) Cultural History of Tourism 3  

E-print Network

Management of Small and Medium Enterprises 3 Tourism Planning and Development 3 THIRD SEMESTER (33 ECTS PROGRAMME Master of Arts in International Tourism INTERNATIONAL TOURISM GOALS AND CONTENTS Having developed SEMESTER Cultural History of Tourism The course will offer an overview concerning the rise and development

Krause, Rolf

185

Multiple Dimensions of Balance are Adversely A ected in Older Adults with Fibromyalgia  

E-print Network

Multiple Dimensions of Balance are Adversely A ected in Older Adults with Fibromyalgia Table 1 Fibromyalgia Age * Body Mass Index Number of Medications Mini-Mental Exam Number of Falls * Total FAB Scale.641 p = 0.894 p = 0.002 p = 0.015 Group Differences Introduction Individuals diagnosed with Fibromyalgia

de Lijser, Peter

186

Microsoft Word - App 9-2 ECT Form Specs.doc  

Cancer.gov

Appendix 9-2 1 Lung Screening Study Version 3.0 Manual of Operations and Procedures 11/15/00 Lung Screening Study Specifications for Completion of the Record of Experience, Credentials and Training (ECT) (Examiner/Quality Assurance Examiner/Abstractor/Nosologist

187

An Assessment of the ECTS in Software Engineering: A Teaching Experience  

Microsoft Academic Search

Spain is currently implementing the regulatory modifications promulgated by the Declaration of Bologna, which should result in the updating of the structure of university degrees, and the inclusion of the European Credit Transfer and Accumulation System (ECTS) methodology. In some Spanish universities, the experimental adoption of this methodology has been encouraged, with the aim of gaining experience which could be

Lorenzo Salas-Morera; Joaquina Berral-Yeron; Inmaculada Serrano-Gomez; Pilar Martinez-Jimenez

2009-01-01

188

Initial Results from a Study of the E ects of Meditation on Multitasking Performance  

E-print Network

Initial Results from a Study of the E ects of Meditation on Multitasking Performance MEDITATION CONTROL MEDITATION RELAXATION 8 weeks 8 weeks memorytask performance/strategy None of the groups showed the meditation group demonstrated a major change in multi- tasking strategy, namely, a marked tendency to spend

Wobbrock, Jacob O.

189

Master's project in biology/immunology, 30 and 45 ECTS Exploring autoreactive B lymphocytes  

E-print Network

of immunological techniques and equipment - Weekly lab meetings, journal clubs and seminars in immunologyMaster's project in biology/immunology, 30 and 45 ECTS Exploring autoreactive B lymphocytes Project have a relevant background with completed courses in immunology and/or infectious biology. -Experience

Uppsala Universitet

190

On the E ect of Compliance in Robotic Contact Tasks Problem  

E-print Network

1 1995 ACC On the E ect of Compliance in Robotic Contact Tasks Problem Shahram Payandeh, Assistant Professor Experimental Robotics Laboratory ERL School of Engineering Science Simon Fraser University Burnaby Introduction Various methodologies have been proposed in the literature for stable control of the robotic

191

The AC Stark E#ect, Time--Dependent Born--Oppenheimer Approximation, and  

E-print Network

The AC Stark E#ect, Time--Dependent Born--Oppenheimer Approximation, and Franck--Condon Factors by a classical oscillatory electric field, and we employ the Born--Oppenheimer approximation for the molecule. We-- Condon factors that we compute explicitly to leading order in the Born--Oppenheimer parameter. We also

Rousse, Vidian

192

The AC Stark E ect, Time{Dependent Born{Oppenheimer Approximation, and  

E-print Network

The AC Stark E#11;ect, Time{Dependent Born{Oppenheimer Approximation, and Franck{Condon Factors the laser pulse by a classical oscillatory electric #12;eld, and we employ the Born{Oppenheimer. These amplitudes contain Franck{ Condon factors that we compute explicitly to leading order in the Born{Oppenheimer

Hagedorn, George A.

193

Analysis of the Type IIn Supernova 1998S: E ects of Circumstellar Interaction on Observed Spectra  

E-print Network

Analysis of the Type IIn Supernova 1998S: E#11;ects of Circumstellar Interaction on Observed of the Type IIn supernova 1998S using the general non-local thermodynamic equiblibrium spectral synthesis code PHOENIX. We model both the underlying supernova spectrum and the overlying circum- stellar interaction

194

Resubmitted to Icarus journal Yarkovsky e ect on small near{Earth asteroids  

E-print Network

Resubmitted to Icarus journal Yarkovsky e#11;ect on small near{Earth asteroids: Mathematical demonstrated in relation to the transport of material from the main asteroid belt (both to explain the origin of near{Earth asteroids and some properties of meteorites) and also in relation to the aging processes

Milani, Andrea

195

Retrograde peri-implantitis  

PubMed Central

Retrograde peri-implantitis constitutes an important cause for implant failure. Retrograde peri-implantitis may sometimes prove difficult to identify and hence institution of early treatment may not be possible. This paper presents a report of four cases of (the implant placed developing to) retrograde peri-implantitis. Three of these implants were successfully restored to their fully functional state while one was lost due to extensive damage. The paper highlights the importance of recognizing the etiopathogenic mechanisms, preoperative assessment, and a strong postoperative maintenance protocol to avoid retrograde peri-implant inflammation. PMID:20922082

Mohamed, Jumshad B.; Shivakumar, B.; Sudarsan, Sabitha; Arun, K. V.; Kumar, T. S. S.

2010-01-01

196

Subcutaneous implantable cardiac defibrillators: indications and limitations.  

PubMed

The implantable cardioverter defibrillator is today an indisputable evidence-based treatment for cardiac sudden death both in primary and secondary prevention. However, trans-venous cardioverter defibrillator implantation still carries a not negligible risk of complications both acutely and during follow-up. Trans-venous endocardial lead is the weak link of implantable cardioverter defibrillator (ICD) technology being the source of most mechanical complications on vessels and heart structures and exposed to infection, malfunction and recalls. A totally subcutaneous defibrillation lead has recently been introduced in clinical practice. With the subcutaneous pulse generator forms a defibrillation system that leaves the vessels and the heart completely "untouched." Subcutaneous ICD has proven to be safe and effective in many clinical trials. Patients without pacing indications and at higher risk of complications from trans-venous lead implantation represent the perfect candidates to S-ICD technology. However, with technical improvement, it is reasonable to expect a further expansion of indications. PMID:25475178

Bongiorni, Maria Grazia; Viani, Stefano; Zucchelli, Giulio; Di Cori, Andrea; Segreti, Luca; Paperini, Luca; Levorato, Dianora; Boem, Adriano; Branchitta, Giulia; Andreini, Diana; Soldati, Ezio

2015-02-01

197

30 GHz monolithic balanced mixers using an ion-implanted FET-compatible 3-inch GaAs wafer process technology  

NASA Technical Reports Server (NTRS)

An all ion-implanted Schottky barrier mixer diode which has a cutoff frequency greater than 1000 GHz has been developed. This new device is planar and FET-compatible and employs a projection lithography 3-inch wafer process. A Ka-band monolithic balanced mixer based on this device has been designed, fabricated and tested. A conversion loss of 8 dB has been measured with a LO drive of 10 dBm at 30 GHz.

Bauhahn, P.; Contolatis, A.; Sokolov, V.; Chao, C.

1986-01-01

198

Science Highlights from the RBSP-ECT Particle Instrument Suite on NASA's Van Allen Probes Mission  

NASA Astrophysics Data System (ADS)

The NASA Van Allen Probes mission includes an instrument suite known as the Radiation Belt Storm Probes (RBSP) - Energetic Particle, Composition, and Thermal Plasma (ECT) suite. RBSP-ECT contains a well-proven complement of particle instruments to ensure the highest quality measurements ever made in the radiation belts and the inner magnetosphere. The coordinated RBSP-ECT particle measurements, analyzed in combination with fields and waves observations and state of-the-art theory and modeling, provide new understanding on the acceleration, global distribution, and variability of radiation belt electrons and ions, key science objectives of NASA's Living With a Star program and the Van Allen Probes mission. The RBSP-ECT suite consists of three highly-coordinated instruments: the Helium Oxygen Proton Electron (HOPE) spectrometer, the Magnetic Electron Ion Spectrometer (MagEIS), and the Relativistic Electron Proton Telescope (REPT). Collectively these three instrument types cover comprehensively the full electron and ion spectra from one eV to 10's of MeV with sufficient energy resolution, pitch angle coverage and resolution, and with composition measurements in the critical energy range up to 50 keV and also from a few to 50 MeV/nucleon. All three instruments are based on measurement techniques proven in the radiation belts, then optimized to provide unambiguous separation of ions and electrons and clean energy responses even in the presence of extreme penetrating background environments. In this presentation, we summarize overall ECT science goals and then show scientific results derived from the ECT suite on the dual Van Allen Probes spacecraft to date. Mission operations began only in late October 2012, and we have now achieved significant results. Results presented here will include substantial progress toward resolving primary Van Allen Probes science targets, such as: the relative role of localized acceleration versus transport-generated particle acceleration; the role of plasma electron temperature anisotropies, whistler waves, and radiation belt electron variability; global characteristics of outer zone electron drift loss to the magnetopause; the role of storms, substorms, and ion composition in radiation belt dynamics, both in terms of sources and sinks; new physical perspectives on inner zone and slot protons and electrons; and, how plasmasphere properties control or influence radiation belt behavior.

Spence, Harlan

2014-05-01

199

Early Science Results From the NASA Van Allen Probes Mission RBSP-ECT Instrument Suite  

NASA Astrophysics Data System (ADS)

The NASA Van Allen Probes mission includes an instrument suite known as the Radiation Belt Storm Probes (RBSP) - Energetic Particle, Composition, and Thermal Plasma (ECT) suite. RBSP-ECT contains a well-proven complement of particle instruments to ensure the highest quality measurements ever made in the radiation belts and the inner magnetosphere. The coordinated RBSP-ECT particle measurements, analyzed in combination with fields and waves observations and state of-the-art theory and modeling, provide new understanding on the acceleration, global distribution, and variability of radiation belt electrons and ions, key science objectives of NASA's Living With a Star program and the Van Allen Probes mission. The RBSP-ECT suite consists of three highly-coordinated instruments: the Helium Oxygen Proton Electron (HOPE) spectrometer, the Magnetic Electron Ion Spectrometer (MagEIS), and the Relativistic Electron Proton Telescope (REPT). Collectively these three instrument types cover comprehensively the full electron and ion spectra from one eV to 10's of MeV with sufficient energy resolution, pitch angle coverage and resolution, and with composition measurements in the critical energy range up to 50 keV and also from a few to 50 MeV/nucleon. All three instruments are based on measurement techniques proven in the radiation belts, then optimized to provide unambiguous separation of ions and electrons and clean energy responses even in the presence of extreme penetrating background environments. In this presentation, we summarize overall ECT science goals and then show early scientific results derived from the ECT suite on the dual Van Allen Probes spacecraft. Mission operations began only in late October 2012, but we have already achieved significant early results. Results presented here will include substantial progress toward resolving primary Van Allen Probes science targets, such as: the relative role of localized acceleration versus transport-generated particle acceleration; the role of plasma electron temperature anisotropies, whistler waves, and radiation belt electron variability; global characteristics of outer zone electron drift loss to the magnetopause; the role of storms, substorms, and ion composition in radiation belt dynamics, both in terms of sources and sinks; new physical perspectives on inner zone and slot protons and electrons; and, how plasmasphere properties control or influence radiation belt behavior.

Spence, Harlan; Reeves, Geoff; Rbspect Team

2013-04-01

200

Remote monitoring for implantable cardiac electronic devices.  

PubMed

Pacemaker and implantable defibrillator implantation rates have increased significantly over the last decade. This, along with increasing complexity of the devices, has placed a large burden on the physicians and technicians that provide the follow up services for these patients. Recently technological advances have allowed remote interrogation of pacemakers and defibrillators with subsequent transmission of this information to a remote location for assessment. The technology behind remote device follow up, the potential advantages and the status of this technology is addressed in this article. PMID:22520207

Young, Glenn D

2012-06-01

201

Improved medical implants comes from nanostructuring  

E-print Network

. A more recent innovation in metals technology--nanostructuring--heralds a new era for metals in medical exclusively licensed the patented nanostructuring technology from Los Alamos National Laboratory to make Dental Inc., has resulted in the development of three new BiotaniumTM dental implants lines, all made

202

Computer-Aided Implant Dentistry  

Microsoft Academic Search

\\u000a Computer-aided implant dentistry (CAID), the direct translation of preoperative prosthetic planning to the operating theater\\u000a by means of image guidance technologies, is a novel application of computer aided surgery (CAS). This work deals with the\\u000a application of a modular software system for computer-aided interventions to CAID. The system is based on AVW-2.5, a software\\u000a library dedicated to biomedical image processing,

Wolfgang Birkfellner; Peter Solar; André Gahleitner; Klaus Huber; Franz Kainberger; Joachim Kettenbach; Peter Homolka; Markus Diemling; Georg Watzek; Helmar Bergmann

203

The Italian regulation on Assisted Reproductive Technologies facing the European Court of Human Rights: the case of Costa and Pavan v. Italy.  

PubMed

This article will describe the current legal framework on Assisted Reproduction Technology (ART) regulation in Italy, taking into account recent case-law derived from the implementation of the Law 40 of 2004 on ART. Special attention will be devoted to the case of Costa and Pavan v. Italy, recently decided by the Tenth Session of the European Court of Human Rights (ECtHR). In that decision, the European Court declared the incompatibility of the ban to pre-implantation genetic diagnosis introduced by the abovementioned Italian law on ART. The case will be analysed from a dual perspective. On the one hand, it will be considered in the light of the ECtHR case-law, in order to derive systematic aspects of continuity or discontinuity between the former and the latter2. On the other hand, the case will be considered in the light of its concrete and prospective impact on the Italian legal approach to ART regulation, considering especially the direct and indirect influence of the case: e.g., its possible utilisation by Italian judges when they are called upon to implement Law 40. PMID:23520918

Penasa, Simone

2012-01-01

204

Scientific Data Processing for the ECT (Energetic Particle, Composition & Thermal Plasma Suite) on NASA's RBSP (Radiation belt Storm Probes) Mission  

NASA Astrophysics Data System (ADS)

Los Alamos is leading the Science Operations Center (SOC) for the Energetic Particle, Composition, and Thermal Plasma Suite (ECT) for NASA's upcoming Radiation Belt Storm Probe Mission (RBSP). Here we present the ECT team's facilities for making data available to both the ECT team and the public. The ECT-SOC will make extensive use of resources such as Autoplot, which will be tightly integrated into a modern version and process control system developed at LANL. In order to support the scientific investigations at the heart of the RBSP mission we make use of existing LANL resources to provide data in PSD format at constant adiabatic invariants, using the LANLGeoMag library and processing pipeline developed for the LANL DREAM (Dynamic Radiation Environment Assimilation Model). We intend to also present here the first runs of DREAM using the RBSP Space Weather Beacon real-time data.

Friedel, R. H.; Henderson, M. G.; Morley, S.; Reeves, G. D.; Niehof, J. T.

2012-12-01

205

Ketofol-Dexmedetomidine combination in ECT: A punch for depression and agitation  

PubMed Central

Background and Aims: The choice of anaesthetic agent for electroconvulsive therapy (ECT) depends on seizure duration, haemodynamic, and recovery parameters. The aim of the study was to assess the effects of ketamine-propofol induction with dexmedetomidine preadministration (ketofol-dex group) and without its preadministration (ketofol group) on haemodynamics, depression, seizure duration, recovery characteristics, and agitation following ECT in patients with depression. Methods: 40 patients aged 18-60 years were scheduled for ECT for treatment of depression. Dexmedetomidine (0.5 ?g/kg) diluted to a volume of 10 ml with 0.9% saline or 10 ml 0.9% saline were infused intravenously over 10 minutes before induction of anaesthesia with ketamine and propofol (ketofol). Statistical analysis was carried out using the Statistical Software for the Social Sciences (SPSS) package. Results: Motor seizure duration in ketofol group was significantly less compared to ketofol-dex group (35.8 ± 6.6s versus 38.9 ± 4.9s). Total ketofol used was significantly less in ketofol-dex group compared to ketofol group (78.5 ± 10.8mg versus 90 ± 13.2mg). The number of patients with agitation score >2 was significantly lower in ketofol-dex group (1.4%) compared to ketofol group (8.6%). There was significant decrease (P = 0.000) in mean arterial pressure (MAP) and heart rate (HR) in ketofol-dex group compared to ketofol group at 20, 30, and 40 minutes for MAP and at 10, 20, 30, and 40 minutes for HR. Conclusions: Ketofol-dex mixture in ECT is associated with longer mean seizure duration, effective anti-depression, less incidence of agitation, more patient satisfaction, and acceptable decreases in blood pressure and HR when compared to ketofol alone. PMID:25024469

Shams, Tarek; El-Masry, Ragaa

2014-01-01

206

USDA Forest Service RMRS-GTR-265. 2011. 27 III. insEcts  

E-print Network

USDA Forest Service RMRS-GTR-265. 2011. 27 III. insEcts By Jose F. Negrón RMRS research on insectCullough 2006). The former has killed numerous maples, elms, and willows in New York and Chicago and the latter in 2003 (Negrón and others 2005). The insect utilizes various species of elms as hosts and tree mortality

207

Test Particle Simulation of Thermal Plasma Distribution Observed by the HOPE Instrument on RBSP-ECT  

NASA Astrophysics Data System (ADS)

We analyze and simulate the `first-light' plasmaspheric thermal plasma measurements from the Helium Oxygen Proton Electron (HOPE) instruments, part of the Energetic Particle, Composition, and Thermal Plasma Suite (ECT) onboard the Radiation Belts Storm Probes (RBSP) mission. A plasmaspheric test particle (PTP) simulation is run to reproduce and provide global contextual information for the dawnside HOPE observations, allowing us to estimate the thermal plasma environment experienced by radiation belt electrons.

Goldstein, J.; Spence, H. E.; Reeves, G. D.; Thomsen, M. F.; Skoug, R. M.; Funsten, H. O.; Livi, R.

2012-12-01

208

Depth sizing of partial-contact stress corrosion cracks from ECT signals  

Microsoft Academic Search

A partial-contact stress corrosion crack (SCC) is electrically modeled as a crack region with non-zero conductivity in eddy current testing (ECT). This partial-contact effect is excluded by an optimally designed crack-conductivity-insensitive depth characterization signal function (DCSF), and consequently the master curves obtained from electric-discharge machining (EDM) notches can be utilized directly in the depth sizing of SCCs. Furthermore, a crack

Weiying Cheng; Shigeru Kanemoto; Ichiro Komura; Mitsuharu Shiwa

2006-01-01

209

Urinary incontinence - injectable implant  

MedlinePLUS

Injectable implants are injections of material into the urethra to help control urine leakage ( urinary incontinence ) caused by a ... into the tissue next to the sphincter. The implant procedure is usually done in the hospital. Or ...

210

Pacemakers and Implantable Defibrillators  

MedlinePLUS

... arrhythmia is serious, you may need a cardiac pacemaker or an implantable cardioverter defibrillator (ICD). They are ... are implanted in your chest or abdomen. A pacemaker helps control abnormal heart rhythms. It uses electrical ...

211

The Ion Implanter  

NSDL National Science Digital Library

This web site displays and describes the major components of a modern high current ion implanter. It uses a series of clickable image maps to help navigate. The site describes the entire process of ion implantation.

212

Implant-Supported Denture  

MedlinePLUS

... implants for support. Bar-retained dentures — A thin metal bar that follows the curve of your jaw ... dentures) — Each implant in the jawbone holds a metal attachment that fits into another attachment on the ...

213

[Anti-NMDA encephalitis in psychiatry; malignant catatonia, atypical psychosis and ECT].  

PubMed

The symptoms of malignant (lethal) catatonia has been reported similar to initial symptoms of anti-NMDAR encephalitis. Subsequently, this autoimmune limbic encephalitis has been noticed in many psychiatrists. We have experienced several cases with malignant catatonia having anti-NMDAR antibody without clinical signs of encephalitis. Thereafter, we have also found anti-NMDAR antibody positive patients of young females with acute florid psychiatric symptoms without clinical signs of encephalitis. The features of these patients mirror-those of "Atypical psychosis" proposed by Mitsuda in Japan, a notion derived from "Cycloid psychosis" conceptualized by German psychiatrist, Leonhard. Both cycloid and atypical psychosis have coinciding features of acute onset, emotional disturbances, psychomotor disturbances, alternations of consciousness, high prevalence in women and oriented premorbid personality. Both malignant catatonia and atypical psychosis have been known to be effectively treated with modified electro convulsion therapy (m-ECT). Our 5 cases with anti-NMDAR antibody, m-ECT treatments were effective. Infectious encephalitis is contra indication of m-ECT, but this autoimmune encephalitis would be careful indication. Schizophrenia is a common, heterogeneous, and complex disorder with unknown etiology. There is established evidence of NMDAR hypofunction as a central component of the functional disconnectivity; this is one of the most accepted models for schizophrenia. Moreover, autoimmune mechanisms have been proposed to be involved, at least in subgroups of schizophrenia patients. Further research of anti-NMDAR antibody and encephalitis would be important clues for the investigation of schizophrenia, catatonia and atypical psychosis. PMID:25672720

Kanbayashi, Takashi; Tsutsui, Ko; Tanaka, Keiko; Omori, Yuki; Takaki, Manabu; Omokawa, Mayu; Mori, Akane; Kusanagi, Hiroaki; Nishino, Seiji; Shimizu, Tetsuo

2014-01-01

214

Space Science Technology Health General Sci-fi & Gaming Oddities International Business Politics Education Entertainment Sports Implant Maps Heart Electrical Activity In  

E-print Network

current devices. The new device represents the first use of flexible silicon technology for a medical of the large animal. "Our hope is to use this technology for many other kinds of medical applicationsSpace Science Technology Health General Sci-fi & Gaming Oddities International Business Politics

Rogers, John A.

215

Rapid Response of Long-Standing, Treatment-Resistant Non-Catatonic Mutism in Paranoid Schizophrenia with Single ECT session  

PubMed Central

Context: Mutism is a common manifestation of catatonia, but mutism due to other forms of psychopathology and neurological disorders have also been described. Although not common, long-standing mutism has also been a feature of non-catatonic schizophrenia and traditionally responds less to conventional therapies. Case Report: We describe a rare case of paranoid schizophrenia presenting with continuous mutism for about 4 years. This 26-year-old male had symptoms of schizophrenia without catatonia. After failed trial of adequate pharmacotherapy and psychological intervention and considering his level of dysfunction, he was started on electroconvulsive therapy (ECT). To our surprise, he improved with a single session of ECT while he was on concurrent pharmacotherapy. We also discuss the possible explanation for this rapid effect of ECT in such clinical presentation. To our knowledge, this is the first case of non-catatonic mutism of schizophrenia of this long duration responding so promptly to ECT, although there are other reports as well in literature, but multiple ECT sessions were applied in those cases. Conclusion: Non-catatonic mutism is perhaps presenting as a cultural variant in this part of the world and whenever encountered, ECT should be an option. Further research should be carried out to validate this idea. PMID:25535609

Dar, Mansoor Ahmad; Rather, Yasir Hassan; Shah, Majid Shafi; Wani, Rayees Ahmad; Hussain, Arshad

2014-01-01

216

Trends in Cochlear Implants  

Microsoft Academic Search

More than 60,000 people worldwide use cochlear implants as a means to restore functional hearing. Although individual performance variability is still high, an average implant user can talk on the phone in a quiet environment. Cochlear-implant research has also matured as a field, as evidenced by the exponential growth in both the patient population and scientific publication. The present report

Fan-Gang Zeng

2004-01-01

217

Cochlear Implantations in Children  

Microsoft Academic Search

Cochlear implant procedures are available for children who are diagnosed with severe hearing loss. Cochlear implants can restore children's perceptions of sound through the use of electronic devices. Perioperative nurses should be knowledgeable about all surgical aspects of cochlear implant procedures and be aware of the months of preparation before surgery and the lengthy rehabilitation afterward. This article discusses the

Athena Stinson

1996-01-01

218

Tricuspid valve incompetence following implantation of ventricular leads.  

PubMed

Most cardiovascular implantable electronic devices (CIEDs) require a ventricular lead to be placed across the tricuspid valve. Tricuspid regurgitation (TR) is an understudied clinical complication of right ventricular lead implantation and its clinical significance is unknown. We review the incidence, predictors, and current management of TR as a complication of ventricular lead implantation. Emerging technologies, including leadless pacing devices and subcutaneous systems, offer the benefit of little or none tricuspid valve disruption. PMID:25488281

Baquero, Giselle A; Luck, Jerry; Naccarelli, Gerald V; Gonzalez, Mario D; Banchs, Javier E

2015-04-01

219

Investigation of the environment of Cr ions implanted into sapphire  

Microsoft Academic Search

MeV ion implantation of transition metals into sapphire (Al2O3), followed by thermal annealing, can produce optically active layers for use in solid state laser technology. We have investigated ion implantation of Cr into sapphire wafers, with co-implantation of O, to encourage formation of optically active Cr3+. The Cr concentration was 0.113 at.%. Annealing temperatures ranged from 600 to 1450 °C.

M. J. Norman; L. D. Morpeth; J. C. McCallum

2002-01-01

220

Investigation of the environment of Cr ions implanted into sapphire  

Microsoft Academic Search

MeV ion implantation of transition metals into sapphire (Al2O3), followed by thermal annealing, can produce optically active layers for use in solid state laser technology. We have investigated ion implantation of Cr into sapphire wafers, with co-implantation of O, to encourage formation of optically active Cr3+. The Cr concentration was 0.113 at.%. Annealing temperatures ranged from 600 to 1450 \\/°C.

M. J. Norman; L. D. Morpeth; J. C. McCallum

2002-01-01

221

Nanotechnology Approaches for Better Dental Implants  

PubMed Central

The combined requirements imposed by the enormous scale and overall complexity of designing new implants or complete organ regeneration are well beyond the reach of present technology in many dimensions, including nanoscale, as we do not yet have the basic knowledge required to achieve these goals. The need for a synthetic implant to address multiple physical and biological factors imposes tremendous constraints on the choice of suitable materials. There is a strong belief that nanoscale materials will produce a new generation of implant materials with high efficiency, low cost, and high volume. The nanoscale in materials processing is truly a new frontier. Metallic dental implants have been successfully used for decades but they have serious shortcomings related to their osseointegration and the fact that their mechanical properties do not match those of bone. This paper reviews recent advances in the fabrication of novel coatings and nanopatterning of dental implants. It also provides a general summary of the state of the art in dental implant science and describes possible advantages of nanotechnology for further improvements. The ultimate goal is to produce materials and therapies that will bring state-of-the-art technology to the bedside and improve quality of life and current standards of care. PMID:21464998

Tomsia, Antoni P.; Launey, Maximilien E.; Lee, Janice S.; Mankani, Mahesh H.; Wegst, Ulrike G.K.; Saiz, Eduardo

2011-01-01

222

Trends in Cochlear Implants  

PubMed Central

More than 60,000 people worldwide use cochlear implants as a means to restore functional hearing. Although individual performance variability is still high, an average implant user can talk on the phone in a quiet environment. Cochlear-implant research has also matured as a field, as evidenced by the exponential growth in both the patient population and scientific publication. The present report examines current issues related to audiologic, clinical, engineering, anatomic, and physiologic aspects of cochlear implants, focusing on their psychophysical, speech, music, and cognitive performance. This report also forecasts clinical and research trends related to presurgical evaluation, fitting protocols, signal processing, and postsurgical rehabilitation in cochlear implants. Finally, a future landscape in amplification is presented that requires a unique, yet complementary, contribution from hearing aids, middle ear implants, and cochlear implants to achieve a total solution to the entire spectrum of hearing loss treatment and management. PMID:15247993

Zeng, Fan-Gang

2004-01-01

223

Miniaturized neural interfaces and implants  

NASA Astrophysics Data System (ADS)

Neural prostheses are technical systems that interface nerves to treat the symptoms of neurological diseases and to restore sensory of motor functions of the body. Success stories have been written with the cochlear implant to restore hearing, with spinal cord stimulators to treat chronic pain as well as urge incontinence, and with deep brain stimulators in patients suffering from Parkinson's disease. Highly complex neural implants for novel medical applications can be miniaturized either by means of precision mechanics technologies using known and established materials for electrodes, cables, and hermetic packages or by applying microsystems technologies. Examples for both approaches will be introduced and discussed. Electrode arrays for recording of electrocorticograms during presurgical epilepsy diagnosis have been manufactured using approved materials and a marking laser to achieve an integration density that is adequate in the context of brain machine interfaces, e.g. on the motor cortex. Microtechnologies have to be used for further miniaturization to develop polymer-based flexible and light weighted electrode arrays to interface the peripheral and central nervous system. Polyimide as substrate and insulation material will be discussed as well as several application examples for nerve interfaces like cuffs, filament like electrodes and large arrays for subdural implantation.

Stieglitz, Thomas; Boretius, Tim; Ordonez, Juan; Hassler, Christina; Henle, Christian; Meier, Wolfgang; Plachta, Dennis T. T.; Schuettler, Martin

2012-03-01

224

UWB for low power, short range, in-body medical implants  

Microsoft Academic Search

Medical implants are battery-powered, and have very stringent power consumption requirements. Devices like pacemakers consume few tens of microamps and last for well over 7-8 years. RF technologies are increasingly enabling communication and configuration of these medical implants. The Federal Communications Commission (FCC) has allocated a dedicated spectrum for operation of medical devices, the Medical Implant Communication System (MICS). This

Ashutosh Ghildiyal; Balwant Godara; Karima Amara; Renzo Dalmolin; Amara Amara

2010-01-01

225

An implantable ZigBee ready telemetric platform for in vivo monitoring of physiological parameters  

Microsoft Academic Search

This paper presents a multiple channel, bidirectional and implantable biotelemetric platform, suitable for real time in vivo monitoring of several physiological parameters. This system consists of an implantable unit, an external host and a user terminal. The ZigBee wireless technology, functioning as telemetric link, enables long battery lifetime and offers the opportunity to build up complex wireless networks of implantable

Pietro Valdastri; Stefano Rossi; Arianna Menciassi; Vincenzo Lionetti; Fabio Bernini; Fabio A. Recchia; Paolo Dario

2008-01-01

226

Resonance ultrasonic vibrations in Cz-Si wafers as a possible diagnostic technique in ion implantation  

Microsoft Academic Search

The semiconductor industry does not have effective metrology for well implants. The ability to measure such deep level implants will become increasingly important as we progress along the technology road map. This work explores the possibility of using the acoustic whistle effect on ion implanted silicon wafers. The technique detects the elastic stress and defects in silicon wafers by measuring

Z. Y. Zhao; S. Ostapenko; R. Anundson; M. Tvinnereim; A. Belyaev; M. Anthony

2001-01-01

227

[Cloning of the ectoine biosynthesis gene ectABC from Halomonas sp. BYS-1 and salt stressed expression in Escherichia coli].  

PubMed

Ectoine was the main compatible solute of moderately halophilic bacteria. In order to clone the ectABC gene which involved in the ectoine biosynthesis pathway from total DNA of moderately halophilic bacteria Halomonas sp. BYS-1, firstly a 750bp fragment of ectABC gene was amplified by PCR using combinations of forward primers and reverse primers designed according to the ectABC genes of Halomonas elongata 2851T and Halomonas elongata DSM3043. Then the upstream and downstream sequences of the 750bp fragment were amplified by SEFA PCR (SElf-Formed Adaptor PCR), a new PCR method amplified relatively long flanking sequences from tagged sequences in a simple way without enzyme excision and ligation. The 3532bp fragment include 2423bp ectABC, 980bp upstream sequences and 129bp downstream sequences were cloned from Halomonas sp. BYS-1 using a pair of conserved primers designed according to acquired sequences by SEFA PCR. The GenBank accession number of the 3532bp fragment is DQ017757. ORF analysis revealed that ectA, ectB, ectC cluster to an operon, the size of ectA, ectB, and ectC were 573bp, 1251bp and 387bp respectively. The predicted molecular masses of the encoded proteins were 21.1kDa (191 amino acids, EctA), 45.7 kDa (417 amino acids, EctB), and 14.5 kDa (129 amino acids, EctC) respectively. The 3532bp fragment was ligated to the MCS site of vector pUC19 and transformed E. coli DH5alpha to construct E. coli (pUC19ECT). Transformant E. coli (pUC19ECT) could synthesis ectoine under salt stress, the intracellular ectoine level were 7.1, 19.4 and 32.3 micromol/(g x dry x wt) when the salinities of the mediums were 0, 0.4 and 0.8mol/L sodium chloride respectively. But the accumulation of ectoine could not promote the growth of E. coli (pUC19ECT)under high salinity. PMID:16579460

He, Jian; Huang, Xing; Gu, Li-feng; Jiang, Jian-dong; Li, Shun-peng

2006-02-01

228

Music Perception with Cochlear Implants: A Review  

PubMed Central

The acceptance of cochlear implantation as an effective and safe treatment for deafness has increased steadily over the past quarter century. The earliest devices were the first implanted prostheses found to be successful in compensating partially for lost sensory function by direct electrical stimulation of nerves. Initially, the main intention was to provide limited auditory sensations to people with profound or total sensorineural hearing impairment in both ears. Although the first cochlear implants aimed to provide patients with little more than awareness of environmental sounds and some cues to assist visual speech-reading, the technology has advanced rapidly. Currently, most people with modern cochlear implant systems can understand speech using the device alone, at least in favorable listening conditions. In recent years, an increasing research effort has been directed towards implant users’ perception of nonspeech sounds, especially music. This paper reviews that research, discusses the published experimental results in terms of both psychophysical observations and device function, and concludes with some practical suggestions about how perception of music might be enhanced for implant recipients in the future. The most significant findings of past research are: (1) On average, implant users perceive rhythm about as well as listeners with normal hearing; (2) Even with technically sophisticated multiple-channel sound processors, recognition of melodies, especially without rhythmic or verbal cues, is poor, with performance at little better than chance levels for many implant users; (3) Perception of timbre, which is usually evaluated by experimental procedures that require subjects to identify musical instrument sounds, is generally unsatisfactory; (4) Implant users tend to rate the quality of musical sounds as less pleasant than listeners with normal hearing; (5) Auditory training programs that have been devised specifically to provide implant users with structured musical listening experience may improve the subjective acceptability of music that is heard through a prosthesis; (6) Pitch perception might be improved by designing innovative sound processors that use both temporal and spatial patterns of electric stimulation more effectively and precisely to overcome the inherent limitations of signal coding in existing implant systems; (7) For the growing population of implant recipients who have usable acoustic hearing, at least for low-frequency sounds, perception of music is likely to be much better with combined acoustic and electric stimulation than is typical for deaf people who rely solely on the hearing provided by their prostheses. PMID:15497033

McDermott, Hugh J.

2004-01-01

229

Differential response to right unilateral ECT in depressed patients: impact of comorbidity and severity of illness [ISRCTN39974945  

PubMed Central

Background Recent electroconvulsive therapy (ECT) efficacy studies of right unilateral (RUL) ECT may not apply to real life clinics with a wide range of patients with major depressive episodes. Methods The study included two groups of patients. In addition to a homogeneous group of patients with major depression according to DSM-IV criteria with severity of the major depressive episode > 16 scores on 17-item Hamilton Rating Scale for Depression (HDRS) (Group 1, n = 16), we included a heterogeneous group of patients with less severe major depressive episodes or with a variety of comorbid conditions (Group 2, n = 24). We randomly assigned the patients to an RUL ECT treatment dosed at 5 or 2.5 times seizure threshold with an intent-to-treat design. The outcomes measured blindly were HDRS, number of treatments, and Mini-Mental State Examination (MMSE). The patients were considered to have responded to treatment if the improvement in HDRS score was at least 60% and they had a total score of less than ten. Results The Group 2 patients responded poorer (8% vs. 63%), and had more often simultaneous worsening in their MMSE scores than Group 1 patients. The differences in the outcomes between the two different doses of RUL ECT treatment were not statistically significant. Conclusions ECT effectiveness seems to be lower in real-life heterogeneous patient groups than in homogeneous patient samples used in experimental efficacy trials. PMID:11846888

Heikman, Pertti; Katila, Heikki; Sarna, Seppo; Wahlbeck, Kristian; Kuoppasalmi, Kimmo

2002-01-01

230

Current status of cochlear implants in Latin America.  

PubMed

In recent years there has been sufficient clinical evidence gathered to show that cochlear implants can benefit a large number of postlingually and prelingually profoundly deaf patients who could not be helped with conventional hearing aids. The number of implanted patients is increasing rapidly around the world in spite of the diverse difficulties in diagnostic, surgical, and rehabilitation procedures involved in this new technology and the controversy among some otologists. Cochlear implant programs started in Latin America more than 10 years ago, and lately the number of cochlear implant teams and implanted patients have increased rapidly. It is the aim of this report to present the results of a recently completed survey regarding the current status of cochlear implant surgery and rehabilitation in Latin America. PMID:8572118

Chiossone, E

1995-03-01

231

Ion implantation method  

SciTech Connect

An ion implantation method is provided which uses an ion implantation apparatus which is capable of focusing an ion beam into a spot having a diameter smaller than the size of a region into which ions are to be implanted. The ion dose is varied in accordance with the gate region, source and drain regions, and the field region of a semiconductor device including a transistor having short gate length and width.

Takigawa, T.; Sasaki, I.

1984-11-06

232

Implantable cardioverter defibrillator during laser transurethral resection of the prostate.  

PubMed

  Implantable cardioverter defibrillators have been instrumental in the health and safety of patients who are at increased risk of sudden death by ventricular tachycardia or fibrillation. Consensus on the perioperative management of cardiovascular implantable electronic devices has suggested that certain surgical interventions (including transurethral resection of the prostate) may interfere with the sensing capability of the device, thereby resulting in unforeseen adverse outcomes. However, improvements in the implantable cardioverter defibrillators have made it less susceptible to surgical interference. In addition, current guidelines recommend deactivation of the implantable cardioverter defibrillators to an asynchronous mode prior to most surgical interventions. We present the first two case reports in which implantable cardioverter defibrillators were not deactivated prior to GreenLight 180-W XPS laser-guided transurethral resection of the prostate. We left the implantable cardioverter defibrillators activated to allow them to detect and treat lethal arrhythmias by direct rather than extrinsic cardioversion. There was no cardiac arrhythmia incident in these two cases. Laser technology is not a documented source of electromagnetic interference in patients with implantable cardioverter defibrillators. There is no current evidence that links lasers to implantable cardioverter defibrillators malfunction. With increasing numbers of patients with implantable cardioverter defibrillators undergoing many different laser surgical procedures, further studies are warranted to analyze in depth the effects of laser therapy on implantable cardioverter defibrillators function and update in current guidelines. PMID:24800199

Deroee, A F; Cohen, B J; O'Hara, J F

2014-01-01

233

Auditory brainstem implantation.  

PubMed

The use of cochlear implants for selected individuals with bilateral severe to profound sensorineural hearing loss who derive limited benefit from conventional hearing aids is well established. There are situations where cochlear implantation is contraindicated. Auditory brainstem implantation (ABI) is the only solution to restore hearing when the cochlear nerve is disrupted together with pathologies where the cochlea does not provide a suitable location for cochlear implant. Labyrinthine and cochlear aplasia and cochlear nerve aplasia constitute the congenital indications for ABI. In the present review article history and development of ABI, indications, side selection criteria, surgery and audiological outcome are presented. PMID:22196501

Sennaroglu, Levent; Ziyal, Ibrahim

2012-10-01

234

Integrated programmable current source for implantable medical devices  

Microsoft Academic Search

In this paper an integrated current source is presented. The source is digitally programmable and can be used on implantable medical devices. It was designed in AMI C5 (0.5 mum) technology, and it is currently under fabrication.

Juan Osta; Julio Suárez; Matías Miguez; Alfredo Arnaud

2009-01-01

235

Planning for immediate loading of implant-supported prostheses: literature review.  

PubMed

The aim of this study was to present the factors that influence planning for immediate loading of implants through a literature review for treatment success. Research was conducted in the PubMed database including the key words immediate implant loading, implant-supported prostheses, and implant planning for studies published from 2000 to 2011. Forty-eight articles were used in this review to describe the indications and counterindications, presurgical planning, and technologies available for planning of this treatment alternative. PMID:21574835

Delben, Juliana Aparecida; Goiato, Marcelo Coelho; Pellizzer, Eduardo Piza; Magro Filho, Osvaldo

2012-09-01

236

Pediatric cochlear implantation: candidacy evaluation, medical and surgical considerations, and expanding criteria.  

PubMed

Since the first cochlear implant approved by the US Food and Drug Administration in the early 1980s, great advances have occurred in cochlear implant technology. With these advances, patient selection, preoperative evaluation, and rehabilitation consideration continue to evolve. This article describes the current practice in pediatric candidacy evaluation, reviews the medical and surgical considerations in pediatric cochlear implantation, and explores the expanding criteria for cochlear implantation within the pediatric population. PMID:22115681

Heman-Ackah, Selena E; Roland, J Thomas; Haynes, David S; Waltzman, Susan B

2012-02-01

237

IDENTIFICATION OF WOODY PLANTS WITH IMPLANTED MICROCHIPS  

Technology Transfer Automated Retrieval System (TEKTRAN)

Secure identification of individual plants by some kind of labels in field plantings is an important part of many types of horticultural, plant, and ecological research. This report describes implanted microchips as one method of plant tagging that is reliable, durable and secure. This technology ...

238

Who Is an Implant Candidate?  

MedlinePLUS

Who Is an Implant Candidate? If you're interested in replacing a missing tooth or teeth, dental implants may be an option for you. Most people are good candidates for implants. A good candidate should have the following: Healthy ...

239

Additively manufactured porous tantalum implants.  

PubMed

The medical device industry's interest in open porous, metallic biomaterials has increased in response to additive manufacturing techniques enabling the production of complex shapes that cannot be produced with conventional techniques. Tantalum is an important metal for medical devices because of its good biocompatibility. In this study selective laser melting technology was used for the first time to manufacture highly porous pure tantalum implants with fully interconnected open pores. The architecture of the porous structure in combination with the material properties of tantalum result in mechanical properties close to those of human bone and allow for bone ingrowth. The bone regeneration performance of the porous tantalum was evaluated in vivo using an orthotopic load-bearing bone defect model in the rat femur. After 12 weeks, substantial bone ingrowth, good quality of the regenerated bone and a strong, functional implant-bone interface connection were observed. Compared to identical porous Ti-6Al-4V structures, laser-melted tantalum shows excellent osteoconductive properties, has a higher normalized fatigue strength and allows for more plastic deformation due to its high ductility. It is therefore concluded that this is a first step towards a new generation of open porous tantalum implants manufactured using selective laser melting. PMID:25500631

Wauthle, Ruben; van der Stok, Johan; Amin Yavari, Saber; Van Humbeeck, Jan; Kruth, Jean-Pierre; Zadpoor, Amir Abbas; Weinans, Harrie; Mulier, Michiel; Schrooten, Jan

2015-03-01

240

A 2-D enlarged cell technique (ECT) for elastic wave modelling on a curved free surface  

NASA Astrophysics Data System (ADS)

The conventional finite-difference time-domain (FDTD) method for elastic waves suffers from the staircasing error when applied to model a curved free surface because of the structured grid. This is similar to the situation for the FDTD method in electromagnetics when it is applied to model a curved perfect conductor surface, where the conformal FDTD methods have been recently developed to avoid this error. In this work a stable and second-order accurate 2-D FDTD method for elastic wave modelling on a curved free surface is presented based on the finite volume method and enlarged cell technique (ECT). To achieve a sufficiently accurate implementation, a finite volume scheme is applied to the curved free surface to remove the staircasing error; in the meantime, to achieve the same stability as the FDTD method without reducing the time step increment, the ECT is introduced to preserve the solution stability even for small irregular cells. This method is verified by several 2-D numerical examples. Results show that the method is second-order accurate and stable at the Courant stability limit for a regular FDTD grid.

Wei, Songlin; Zhuang, Mingwei; Zhou, Jianyang; Liu, Qing Huo

2015-04-01

241

Somatic therapies for treatment-resistant depression: ECT, TMS, VNS, DBS  

PubMed Central

The field of non-pharmacological therapies for treatment resistant depression (TRD) is rapidly evolving and new somatic therapies are valuable options for patients who have failed numerous other treatments. A major challenge for clinicians (and patients alike) is how to integrate the results from published clinical trials in the clinical decision-making process. We reviewed the literature for articles reporting results for clinical trials in particular efficacy data, contraindications and side effects of somatic therapies including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), vagal nerve stimulation (VNS) and deep brain stimulation (DBS). Each of these devices has an indication for patients with different level of treatment resistance, based on acuteness of illness, likelihood of response, costs and associated risks. ECT is widely available and its effects are relatively rapid in severe TRD, but its cognitive adverse effects may be cumbersome. TMS is safe and well tolerated, and it has been approved by FDA for adults who have failed to respond to one antidepressant, but its use in TRD is still controversial as it is not supported by rigorous double-blind randomized clinical trials. The options requiring surgical approach are VNS and DBS. VNS has been FDA-approved for TRD, however it is not indicated for management of acute illness. DBS for TRD is still an experimental area of investigation and double-blind clinical trials are underway. PMID:22901565

2012-01-01

242

Micro- and nano-fabricated implantable drug-delivery systems  

PubMed Central

Implantable drug-delivery systems provide new means for achieving therapeutic drug concentrations over entire treatment durations in order to optimize drug action. This article focuses on new drug administration modalities achieved using implantable drug-delivery systems that are enabled by micro- and nano-fabrication technologies, and microfluidics. Recent advances in drug administration technologies are discussed and remaining challenges are highlighted. PMID:23323562

Meng, Ellis; Hoang, Tuan

2013-01-01

243

Pacemaker implantation after transcatheter aortic valve implantation.  

PubMed

Thirty- to 35% of patients after transcatheter aortic valve implantation undergo implantation of a permanent pacemaker (PPM) because of development of atrioventricular block (AVB) or development of a condition with high risk of progression to AVB. There are insufficient data regarding long-term follow-up on pacing dependency. From February 2009 to July 2011, 191 transcatheter aortic valve implantation procedures were performed at the Rabin Medical Center (125 CoreValve and 66 Edwards SAPIEN). Thirty-two patients (16.7%) received a PPM (30 with CoreValve and 2 with Edwards SAPIEN). Data from the pacemaker clinic follow-up was available in 27 patients. After a mean follow-up of 52 weeks (range, 22 to 103), only 8 (29%) of 27 patients were pacing dependent. The indication of PPM in these 8 patients was complete AVB. In conclusion, in our center, the rate of PPM implantation was 16%, which is lower than that reported in the published works. Only 29% of those patients implanted with PPM were pacemaker dependent. Further studies are necessary to define reliable predictors for long-term pacing. PMID:23998348

Goldenberg, Gustavo; Kusniec, Jairo; Kadmon, Ehud; Golovchiner, Gregory; Zabarsky, Ronit; Nevzorov, Roman; Vaknin, Hana; Assali, Abed; Kornowski, Ran; Haim, Moti; Strasberg, Boris

2013-11-15

244

Current Internet Technology and Statistics | Blessing or Curse? Jurgen Symanzik  

E-print Network

Current Internet Technology and Statistics | Blessing or Curse? Jurgen Symanzik George Mason overview on the history of the Internet and some of its main features. In the second part, we introduce exist- ingInternet technology that e ects todays education and research in Statistics. Examples

Symanzik, Jürgen

245

Implantable ultrasound devices  

NASA Astrophysics Data System (ADS)

Using medical implants to wirelessly report physiological data is a technique that is rapidly growing. Ultrasound is well-suited for implants -- it requires little power and this form of radiated energy has no ill effects on the body. We report here on techniques we have developed in our experience gained in implanting over a dozen Doppler ultrasound flow-measuring implants in dogs. The goal of our implantable device is to measure flow in an arterial graft. To accomplish this, we place a Doppler transducer in the wall of a graft and an implant unit under the skin that energizes the 20 MHz Doppler transducer system, either when started by external command or by internal timetable. The implant records the digitized Doppler real and imaginary channels and transmits the data to a nearby portable computer for storage and evaluation. After outlining the overall operation of the system, we will concentrate on three areas of implant design where special techniques are required: ensuring safety, including biocompatibility to prevent the body from reacting to its invasion; powering the device, including minimizing energy used so that a small battery can provide long-life; and transmitting the data obtained.

Vilkomerson, David; Chilipka, Thomas; Bogan, John; Blebea, John; Choudry, Rashad; Wang, John; Salvatore, Michael; Rotella, Vittorio; Soundararajan, Krishnan

2008-03-01

246

Implantable, Ingestible Electronic Thermometer  

NASA Technical Reports Server (NTRS)

Small quartz-crystal-controlled oscillator swallowed or surgically implanted provides continuous monitoring of patient's internal temperature. Receiver placed near patient measures oscillator frequency, and temperature inferred from previously determined variation of frequency with temperature. Frequency of crystal-controlled oscillator varies with temperature. Circuit made very small and implanted or ingested to measure internal body temperature.

Kleinberg, Leonard

1987-01-01

247

Should surgeons still be implanting pacemakers?  

PubMed

Cardiac pacing has undergone major changes in the areas of manpower, technology, and cost over the past 10 years. Arguments have been made to eliminate cardiac surgical involvement in pacing on the basis of these three areas of change: implantations are increasingly performed by nonsurgeons, surgeons have not kept up with the technologic advances in pacing, and consolidation of bradypacing resources is necessary during a time when reimbursement has declined significantly. This study examined two eras of pacing therapy at an institution where pacemaker implantation has always been performed by cardiothoracic surgeons. The purpose of the study was to critically analyze (1) the current role (if any) of cardiothoracic surgeons in delivery of pacemaker therapy and (2) the current results of cardiothoracic surgical involvement in pacemaker implantation. In 1,562 procedures performed between 1986 and 1992, the infection rate was 0.51% and the overall complication rate (both short-term and long-term) was 5.2%. During era 1 (1/1/86 to 6/30/89), 80% of implants were single-chamber and follow-up was incomplete and dependent in many instances on the referring cardiologist/internist. For the implantations performed in the second era (7/1/89 to 12/31/92) as part of an established Pacemaker Service, complete clinical and transtelephonic follow-up services were provided by this coordinated medical-surgical approach. During era 2, 53.9% of implants were dual-chamber (79% during 1992). Total and infectious complication rates remained low in era 2 despite this change in technology.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8147626

Ferguson, T B; Lindsay, B D; Boineau, J P

1994-03-01

248

Graphene for Biomedical Implants  

NASA Astrophysics Data System (ADS)

In this study, we used graphene, a one-atom thick sheet of carbon atoms, to modify the surfaces of existing implant materials to enhance both bio- and hemo-compatibility. This novel effort meets all functional criteria for a biomedical implant coating as it is chemically inert, atomically smooth and highly durable, with the potential for greatly enhancing the effectiveness of such implants. Specifically, graphene coatings on nitinol, a widely used implant and stent material, showed that graphene coated nitinol (Gr-NiTi) supports excellent smooth muscle and endothelial cell growth leading to better cell proliferation. We further determined that the serum albumin adsorption on Gr-NiTi is greater than that of fibrinogen, an important and well understood criterion for promoting a lower thrombosis rate. These hemo-and biocompatible properties and associated charge transfer mechanisms, along with high strength, chemical inertness and durability give graphene an edge over most antithrombogenic coatings for biomedical implants and devices.

Moore, Thomas; Podila, Ramakrishna; Alexis, Frank; Rao, Apparao

2013-03-01

249

Changes in brain metabolism after ECT–Positron emission tomography in the assessment of changes in glucose metabolism subsequent to electroconvulsive therapy — Lessons, limitations and future applications  

Microsoft Academic Search

BackgroundElectroconvulsive therapy (ECT) has been used as an effective treatment option in severe and treatment resistant cases of depression for decades. However the mode of action of ECT is still not fully understood. Advances in neuroimaging created new possibilities to understand the functional changes of the human brain.

E. Z. Schmidt; B. Reininghaus; C. Enzinger; C. Ebner; P. Hofmann; H. P. Kapfhammer

2008-01-01

250

1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. Module A: Fundamentals of Marine Biology and Ecology (15 ECTS) Modul  

E-print Network

1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. Module A: Fundamentals of Marine Biology and Ecology Biology and Biological Oceanography Principles of Marine Ecophysiology Experimental Design & Data Analysis: Advanced Studies in Marine Biology (18 ECTS) Module G: Project Development & Implementation (9 ECTS

Hoffmeister, Thomas S.

251

Long-Term Modeling of Solar Energy: Analysis of Concentrating Solar Power (CSP) and PV Technologies  

Microsoft Academic Search

This report presents an overview of research conducted on solar energy technologies and their implementation in the ObjECTS framework. The topics covered include financing assumptions and selected issues related to the integration of concentrating thermal solar power (CSP) and photovoltaics PV technologies into the electric grid. A review of methodologies for calculating the levelized energy cost of capital-intensive technologies is

Yabei Zhang; Steven J. Smith

2007-01-01

252

A multiparameter implantable microstimulator SOC  

Microsoft Academic Search

Abstract—Various implantable microstimulators have been proposed for clinical applications in recent years. Most of the no-battery implanted de- vices can be powered by a transcutaneous magnetic coupling, which basi- cally utilizes an external transmitter coil to power and communicate with the implanted device. Small chip area and low power consumption are the keys of the implanted device. Therefore, we propose

Chua-chin Wang; Tzung-je Lee; Yu-tzu Hsiao; U. Fat Chio; Chi-chun Huang; Jia-Jin J. Chin; Ya-hsin Hsueh

2005-01-01

253

Microbiology of the Dental Implant  

Microsoft Academic Search

Longitudinal studies have shown that successful implants are colonized by a predominantly Gram-positive, facultative flora, which is established shortly after implantation. Repeated microbiological sampling in patients with clinically stable implants showed no significant shifts in the composition of this flora over five years. In patients with bone loss and pocket formation around implants, however, a significantly different flora was found:

A. Mombelli

1993-01-01

254

Humiliation and the Inertia E! ect: Implications for Understanding Violence and Compromise in Intractable Intergroup Confl icts  

Microsoft Academic Search

We investigated the infl uence of humiliation on inter-group confl ict in three studies of Palestinians living in the West Bank and Gaza. We demonstrate that experienced humiliation produces an inertia e! ect; a tendency towards inaction that suppresses rebellious or violent action but which paradoxically also suppresses support for acts of inter-group compromise. In Study 1, Palestinians who felt

Jeremy Ginges; Scott Atran

255

Monte Carlo Study of the E ects of Design Parameters on the Sensitivity of a CMB Polarization Experiment  

E-print Network

Monte Carlo Study of the E#11;ects of Design Parameters on the Sensitivity of a CMB Polarization a monte carlo to simulate Cosmic Microwave Background polarization maps on caps around the North Celestial Pole. We used this monte carlo to explore how the sensitivity of a single parameter #12;t depends

256

Department of Computer Science, University of Exeter, U.K. Technical Report No. 389 E ecting a ective communication  

E-print Network

environments is to facilitate communication between entities in that environment, be those entities human users representative of the real world they aim to model, they must both (1) facilitate the communication of a#11;ect#11;ective communication in virtual environments Colin G. Johnson 1 and Gareth J. F. Jones 2 1

Kent, University of

257

Continental Shelf Research 20 (2000) 1}13 Internal tide e!ects on a sewage plume  

E-print Network

Continental Shelf Research 20 (2000) 1}13 Internal tide e!ects on a sewage plume at Sand Island, is described and explained by the forcing from an internal tide. The sewage plume, discharged from the Sand to the di!user, suggested that the presence of an internal tide of 18 km wavelength propagating along

Fabrikant, Sara Irina

258

Coevolution and the Red Queen E#ect Shape Virtual Plants Universitat Wurzburg, Lehrstuhl fur Informatik II  

E-print Network

and rendered with OpenGL. Reproductive success of a plant depends on the amount of virtual light receivedCoevolution and the Red Queen E#ect Shape Virtual Plants Marc Ebner UniversitË?at W though fitness remains constant. We have tested this hypothesis using a population of virtual plants

Ebner, Marc

259

Classi cation of the E ects of F-actin Under Treatment of drugs in Endothelial Cells  

E-print Network

cells with di erent treatment of drugs. These drugs or agonists cause increase in permeabilityClassi cation of the E ects of F-actin Under Treatment of drugs in Endothelial Cells Kamal J and they include -thrombin and histamine. The permeability results in and/or accompanies rearrangement of the F

Farag, Aly A.

260

Antidepressant efficacy of Sudarshan Kriya Yoga (SKY) in melancholia: a randomized comparison with electroconvulsive therapy (ECT) and imipramine  

Microsoft Academic Search

Background: Sudarshan Kriya Yoga (SKY) is a procedure that involves essentially rhythmic hyperventilation at different rates of breathing. The antidepressant efficacy of SKY was demonstrated in dysthymia in a prospective, open clinical trial. This study compared the relative antidepressant efficacy of SKY in melancholia with two of the current standard treatments, electroconvulsive therapy (ECT) and imipramine (IMN). Methods: Consenting, untreated

N. Janakiramaiah; B. N. Gangadhar; P. J. Naga Venkatesha Murthy; M. G. Harish; D. K. Subbakrishna; A. Vedamurthachar

2000-01-01

261

ePUB: Modellierung Molecular Life Sciences Master Major 90 ECTS-Credits with special qualification in Biochemistry/  

E-print Network

in Biochemistry/ Chemical Biology [Reglement 01.10.2005] Seite 1 1. Teil: Struktur des Studiums (Prüfungsfächer) Offizieller Abschluss: Master of Science in Molecular Life Sciences with special qualification in Biochemistry/Chemical Biology, Universität Bern ePUB - interne Bezeichnung: MLS M Major 90 ECTS Biochemistry/Chemical Biology

Richner, Heinz

262

Natural and Engineered Hydroxyectoine Production Based on the Pseudomonas stutzeri ectABCD-ask Gene Cluster? †  

PubMed Central

We report on the presence of a functional hydroxyectoine biosynthesis gene cluster, ectABCD-ask, in Pseudomonas stutzeri DSM5190T and evaluate the suitability of P. stutzeri DSM5190T for hydroxyectoine production. Furthermore, we present information on heterologous de novo production of the compatible solute hydroxyectoine in Escherichia coli. In this host, the P. stutzeri gene cluster remained under the control of its salt-induced native promoters. We also noted the absence of trehalose when hydroxyectoine genes were expressed, as well as a remarkable inhibitory effect of externally applied betaine on hydroxyectoine synthesis. The specific heterologous production rate in E. coli under the conditions employed exceeded that of the natural producer Pseudomonas stutzeri and, for the first time, enabled effective hydroxyectoine production at low salinity (2%), with the added advantage of simple product processing due to the absence of other cosolutes. PMID:21169432

Seip, Britta; Galinski, Erwin A.; Kurz, Matthias

2011-01-01

263

Past and future technologic developments for rhythm and conduction disturbances  

Microsoft Academic Search

Since the first cardiac pacemaker was implanted in 1958,1 continuing technologic innovations have steadily improved the therapeutic power of implantable cardiac device therapy. This evolution has benefited both patients and their physicians, expanding the conditions manageable through pacing and implantable defibrillation while streamlining implant and follow-up procedures. This progress is likely to continue unabated because (1) devices will continue to

Jay Warren

2000-01-01

264

Transcatheter aortic valve implantation  

PubMed Central

Transcatheter aortic valve implantation was developed to offer a therapeutic solution to patients with severe symptomatic aortic stenosis who are not candidates for conventional aortic valve replacement. The improvement in transcatheter aortic valve implantation outcomes is still of concern in the areas of stroke, vascular injury, heart block, paravalvular regurgitation and valve durability. Concomitantly, the progress, both technical and in terms of material advances of transcatheter valve systems, as well as in patient selection, renders transcatheter aortic valve implantation an increasingly viable treatment for more and more patients with structural heart disease. PMID:25374670

Oliemy, Ahmed

2014-01-01

265

DEALING WITH DENTAL IMPLANT FAILURES  

PubMed Central

An implant-supported restoration offers a predictable treatment for tooth replacement. Reported success rates for dental implants are high. Nevertheless, failures that mandate immediate implant removal do occur. The consequences of implant removal jeopardize the clinician's efforts to accomplish satisfactory function and esthetics. For the patient, this usually involves further cost and additional procedures. The aim of this paper is to describe different methods and treatment modalities to deal with dental implant failure. The main topics for discussion include identifying the failing implant, implants replacing failed implants at the exact site, and the use of other restorative options. When an implant fails, a tailor made treatment plan should be provided to each patient according to all relevant variables. Patients should be informed regarding all possible treatment modalities following implant failure and give their consent to the most appropriate treatment option for them. PMID:19089213

Levin, Liran

2008-01-01

266

Ion implantation at elevated temperatures  

SciTech Connect

A kinetic model has been developed to investigate the synergistic effects of radiation-enhanced diffusion, radiation-induced segregation and preferential sputtering on the spatial redistribution of implanted solutes during implantation at elevated temperatures. Sample calculations were performed for Al and Si ions implanted into Ni. With the present model, the influence of various implantation parameters on the evolution of implant concentration profiles could be examined in detail.

Lam, N.Q.; Leaf, G.K.

1985-11-01

267

A touch probe method of operating an implantable RFID tag for orthopedic implant identification.  

PubMed

The major problem in operating an implantable radio-frequency identification (RFID) tag embedded on an orthopedic implant is low efficiency because of metallic interference. To improve the efficiency, this paper proposes a method of operating an implantable passive RFID tag using a touch probe at 13.56 MHz. This technology relies on the electric field interaction between two pairs of electrodes, one being a part of the touch probe placed on the surface of tissue and the other being a part of the tag installed under the tissue. Compared with using a conventional RFID antenna such as a loop antenna, this method has a better performance in the near field operation range to reduce interference with the orthopedic implant. Properly matching the touch probe and the tag to the tissue and the implant reduces signal attenuation and increases the overall system efficiency. The experiments have shown that this method has a great performance in the near field transcutaneous operation and can be used for orthopedic implant identification. PMID:23853323

Liu, Xiaoyu; Berger, J Lee; Ogirala, Ajay; Mickle, Marlin H

2013-06-01

268

Visible Embryo: Implantation begins  

NSDL National Science Digital Library

the page on early implantation and HCG production from a comprehensive resource of information on human development from conception to birth, designed for both medical student and interested lay people.

Carmen Arbona (Mouseworks)

2006-09-08

269

Implant-Supported Bridge  

MedlinePLUS

... made by the dental lab. Porcelain-fused-to-metal bridge The restoration (the part that looks like ... porcelain attached and fused to a framework of metal. The Implant Process The time it takes to ...

270

Technology.  

ERIC Educational Resources Information Center

Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

Online-Offline, 1998

1998-01-01

271

Implantable RFID Chips  

Microsoft Academic Search

Implantable RFID chips are being seen as a potential security device for the very near future with the availability of these\\u000a chips already in the marketplace. The applications are presented in a broadly positive light in their use in contexts that\\u000a range from health monitoring to emergency solutions. But there is a darker side to RFID chips: with their implantation,

Vikas Kumar

272

Optical properties of fluorine implanted ZnMgSe/ZnSe quantum-well nanostructures  

NASA Astrophysics Data System (ADS)

Here we demonstrate the ion-implantation of fluorine as an alternative doping method for ZnMgSe/ZnSe QWs. The photoluminescence measurements of F-implanted ZnSe QWs show the correlation between the number of sharp recombination peaks of F-donor bound-excitons and the implantation dose as well as the saturation of the luminescence intensity related to a donor. When special techniques such as selective implantation through a mask and registration of single ion impacts are applied on micro-, nano-cavities, the ion implantation can be an attractive alternative fluorine doping method for quantum information technology based on fluorine impurities in ZnSe.

Kim, Y. M.; Sleiter, D.; Sanaka, K.; Yamamoto, Y.; Meijer, J.; Lischka, K.; Pawlis, A.

2012-02-01

273

Biomaterials in cochlear implants  

PubMed Central

The cochlear implant (CI) represents, for almost 25 years now, the gold standard in the treatment of children born deaf and for postlingually deafened adults. These devices thus constitute the greatest success story in the field of ‘neurobionic’ prostheses. Their (now routine) fitting in adults, and especially in young children and even babies, places exacting demands on these implants, particularly with regard to the biocompatibility of a CI’s surface components. Furthermore, certain parts of the implant face considerable mechanical challenges, such as the need for the electrode array to be flexible and resistant to breakage, and for the implant casing to be able to withstand external forces. As these implants are in the immediate vicinity of the middle-ear mucosa and of the junction to the perilymph of the cochlea, the risk exists – at least in principle – that bacteria may spread along the electrode array into the cochlea. The wide-ranging requirements made of the CI in terms of biocompatibility and the electrode mechanism mean that there is still further scope – despite the fact that CIs are already technically highly sophisticated – for ongoing improvements to the properties of these implants and their constituent materials, thus enhancing the effectiveness of these devices. This paper will therefore discuss fundamental material aspects of CIs as well as the potential for their future development. PMID:22073103

Stöver, Timo; Lenarz, Thomas

2011-01-01

274

Fully Implantable Blood Pressure System: Implantation Experiences  

Microsoft Academic Search

\\u000a Hypertension is an important risk factor for vascular diseases (arteriosclerosis), renal and heart insufficiency. In Germany,\\u000a approximately 10 million people suffer from hypertension. 10% of the people affected are difficult to medicate. Furthermore,\\u000a 10% of this group are candidates for long term monitoring. Therefore a fully implantable and telemetrically controlled blood\\u000a pressure system is presented to realize a comfortable long

U. Urban; R. Ballan; H. Fassbender; P. Fuerst; T. Goettsche; B. Bender; R. Becker; W. Mokwa; H. K. Trieu; P. Osypka; R. Glocker; U. Steinseifer; T. Schmitz-Rode

275

The use of VIRBO and Autoplot within the automated processing chain for data from the ECT team for the upcoming RBSP mission  

NASA Astrophysics Data System (ADS)

Los Alamos is leading the Science Operations Center (SOC) for the Energetic Particle, Composition, and Thermal Plasma Suite (ECT) for NASA's upcoming Radiation Belt Storm Probe Mission (RBSP). This paper will present the ECT team's plans for making data available to both the ECT team and the public. The ECT-SOC will make extensive use of resources made available through the VIRBO Virtual observatory, and tools such as Autoplot and PaPCo, which will be tightly integrated into a modern version and process control system developed at LANL. ECT data will be available in quicklook and validated format, both as browsable images and ISTP-comliant CDF files. Our process control system will enable us to maintain full control over the version history of all input and output files and individual processes, allowing the re-creation of and specific version of a data product. In the absence of real ECT data we will show examples using existing data from LANL's energetic particle and plasma instruments as "proxies" for the ECT instrumentation HOPE (plasma), MagEIS (high energy) and REPT (very high energies).

Friedel, R. H.; Faden, J.; Weigel, R. S.

2011-12-01

276

Identification and characterization of ectoine biosynthesis genes and heterologous expression of the ectABC gene cluster from Halomonas sp. QHL1, a moderately halophilic bacterium isolated from Qinghai Lake.  

PubMed

The moderately halophilic bacterium Halomonas sp. QHL1 was identified as a member of the genus Halomonas by 16S rRNA gene sequencing. HPLC analysis showed that strain QHL1 synthesizes ectoine in its cytoplasm. The genes involved in the ectoine biosynthesis pathway were identified on the chromosome in the order ectABC. Subsequently, the ectB gene from this strain was amplified by PCR, and the entire ectABC gene cluster (3,580 bp) was cloned using genome walking. Analysis showed that the ectA (579 bp), ectB (1269 bp), and ectC (390 bp) genes were organized in a single transcriptional unit and were predicted to encode three peptides of 21.2 kDa, 46.4 kDa, and 14.7 kDa, respectively. Two putative promoters, a ?(70)-dependent promoter and a ?(38)-controlled promoter, as well as several conserved motifs with unknown function were identified. Individual ectA, ectB, and ectC genes, and the entire ectABC gene cluster were inserted into the expression plasmid pET-28a(+) to generate the recombinant plasmids pET-28a(+)-ectA, pET-28a(+)-ectB, pET-28a(+)-ectC and pET-28a(+)-ectABC, respectively. Heterologous expression of these proteins in Escherichia coli BL21 (DE3) was confirmed by SDS-PAGE. The recombinant E. coli strain BL21 (pET-28a (+)-ectABC) displayed a higher salt tolerance than native E. coli cells but produced far less ectoine than the wild-type QHL1 strain. PMID:24500478

Zhu, Derui; Liu, Jian; Han, Rui; Shen, Guoping; Long, Qifu; Wei, Xiaoxing; Liu, Deli

2014-02-01

277

Maxillary overdentures supported by four splinted direct metal laser sintering implants: a 3-year prospective clinical study.  

PubMed

Purpose. Nowadays, the advancements in direct metal laser sintering (DMLS) technology allow the fabrication of titanium dental implants. The aim of this study was to evaluate implant survival, complications, and peri-implant marginal bone loss of DMLS implants used to support bar-retained maxillary overdentures. Materials and Methods. Over a 2-year period, 120 implants were placed in the maxilla of 30 patients (18 males, 12 females) to support bar-retained maxillary overdentures (ODs). Each OD was supported by 4 implants splinted by a rigid cobalt-chrome bar. At each annual follow-up session, clinical and radiographic parameters were assessed. The outcome measures were implant failure, biological and prosthetic complications, and peri-implant marginal bone loss (distance between the implant shoulder and the first visible bone-to-implant contact, DIB). Results. The 3-year implant survival rate was 97.4% (implant-based) and 92.9% (patient-based). Three implants failed. The incidence of biological complication was 3.5% (implant-based) and 7.1% (patient-based). The incidence of prosthetic complication was 17.8% (patient-based). No detrimental effects on marginal bone level were evidenced. Conclusions. The use of 4 DMLS titanium implants to support bar-retained maxillary ODs seems to represent a safe and successful procedure. Long-term clinical studies on a larger sample of patients are needed to confirm these results. PMID:25580124

Mangano, Francesco; Luongo, Fabrizia; Shibli, Jamil Awad; Anil, Sukumaran; Mangano, Carlo

2014-01-01

278

Maxillary Overdentures Supported by Four Splinted Direct Metal Laser Sintering Implants: A 3-Year Prospective Clinical Study  

PubMed Central

Purpose. Nowadays, the advancements in direct metal laser sintering (DMLS) technology allow the fabrication of titanium dental implants. The aim of this study was to evaluate implant survival, complications, and peri-implant marginal bone loss of DMLS implants used to support bar-retained maxillary overdentures. Materials and Methods. Over a 2-year period, 120 implants were placed in the maxilla of 30 patients (18 males, 12 females) to support bar-retained maxillary overdentures (ODs). Each OD was supported by 4 implants splinted by a rigid cobalt-chrome bar. At each annual follow-up session, clinical and radiographic parameters were assessed. The outcome measures were implant failure, biological and prosthetic complications, and peri-implant marginal bone loss (distance between the implant shoulder and the first visible bone-to-implant contact, DIB). Results. The 3-year implant survival rate was 97.4% (implant-based) and 92.9% (patient-based). Three implants failed. The incidence of biological complication was 3.5% (implant-based) and 7.1% (patient-based). The incidence of prosthetic complication was 17.8% (patient-based). No detrimental effects on marginal bone level were evidenced. Conclusions. The use of 4 DMLS titanium implants to support bar-retained maxillary ODs seems to represent a safe and successful procedure. Long-term clinical studies on a larger sample of patients are needed to confirm these results. PMID:25580124

Mangano, Francesco; Shibli, Jamil Awad; Anil, Sukumaran

2014-01-01

279

Modulation Techniques for Biomedical Implanted Devices and Their Challenges  

PubMed Central

Implanted medical devices are very important electronic devices because of their usefulness in monitoring and diagnosis, safety and comfort for patients. Since 1950s, remarkable efforts have been undertaken for the development of bio-medical implanted and wireless telemetry bio-devices. Issues such as design of suitable modulation methods, use of power and monitoring devices, transfer energy from external to internal parts with high efficiency and high data rates and low power consumption all play an important role in the development of implantable devices. This paper provides a comprehensive survey on various modulation and demodulation techniques such as amplitude shift keying (ASK), frequency shift keying (FSK) and phase shift keying (PSK) of the existing wireless implanted devices. The details of specifications, including carrier frequency, CMOS size, data rate, power consumption and supply, chip area and application of the various modulation schemes of the implanted devices are investigated and summarized in the tables along with the corresponding key references. Current challenges and problems of the typical modulation applications of these technologies are illustrated with a brief suggestions and discussion for the progress of implanted device research in the future. It is observed that the prime requisites for the good quality of the implanted devices and their reliability are the energy transformation, data rate, CMOS size, power consumption and operation frequency. This review will hopefully lead to increasing efforts towards the development of low powered, high efficient, high data rate and reliable implanted devices. PMID:22368470

Hannan, Mahammad A.; Abbas, Saad M.; Samad, Salina A.; Hussain, Aini

2012-01-01

280

Modulation techniques for biomedical implanted devices and their challenges.  

PubMed

Implanted medical devices are very important electronic devices because of their usefulness in monitoring and diagnosis, safety and comfort for patients. Since 1950s, remarkable efforts have been undertaken for the development of bio-medical implanted and wireless telemetry bio-devices. Issues such as design of suitable modulation methods, use of power and monitoring devices, transfer energy from external to internal parts with high efficiency and high data rates and low power consumption all play an important role in the development of implantable devices. This paper provides a comprehensive survey on various modulation and demodulation techniques such as amplitude shift keying (ASK), frequency shift keying (FSK) and phase shift keying (PSK) of the existing wireless implanted devices. The details of specifications, including carrier frequency, CMOS size, data rate, power consumption and supply, chip area and application of the various modulation schemes of the implanted devices are investigated and summarized in the tables along with the corresponding key references. Current challenges and problems of the typical modulation applications of these technologies are illustrated with a brief suggestions and discussion for the progress of implanted device research in the future. It is observed that the prime requisites for the good quality of the implanted devices and their reliability are the energy transformation, data rate, CMOS size, power consumption and operation frequency. This review will hopefully lead to increasing efforts towards the development of low powered, high efficient, high data rate and reliable implanted devices. PMID:22368470

Hannan, Mahammad A; Abbas, Saad M; Samad, Salina A; Hussain, Aini

2012-01-01

281

Mometasone implant for chronic rhinosinusitis  

PubMed Central

The Propel mometasone-eluting stent (Intersect ENT, Palo Alto, CA) is the first Food and Drug Administration-approved device for delivering steroid medication into the ethmoid cavity following surgery. The implant is composed of a biodegradable polymer in a lattice pattern that expands in a spring-like fashion to conform to the walls of a dissected ethmoid cavity and contains a total of 370 ?g of mometasone furoate designed for gradual release over 30 days. The purpose of this article is to review the mode of action and the evidence supporting the efficacy of this novel technology. Three recently published clinical trials have demonstrated that the mometasone-eluting stent produced statistically significant reductions in inflammation, polyp formation, and postoperative adhesions. In addition, the implant has been found to significantly reduce the need for postoperative administration of oral steroids and to decrease the frequency of postoperative lysis of adhesions. Minimal adverse effects were reported in these trials and included infection, crusting, and granulation tissue formation. Although the placement of steroid-impregnated packing, stents, sponges, and gels has previously been used in the postoperative sinus cavities, the Propel mometasone-eluting stent introduces a new mechanism for localized and controlled delivery of topical therapy directly to the nasal mucosa for chronic rhinosinusitis. PMID:23152712

Wei, Calvin C; Kennedy, David W

2012-01-01

282

Laser Additive Manufacturing of Modified Implant Surfaces with Osseointegrative Characteristics  

Microsoft Academic Search

Additive Manufacturing technology, such as Selective Laser Melting, allows fabrication of complex metal parts with freeform surfaces. Using biocompatible metal alloys, e.g. TiAl6V4, medical implants can be produced. To increase osseointegrative behavior the ability to fabricate filigree lattice structures can be utilized to achieve a modified implant surface. In order to increase dimensional accuracy when applying a lattice structure on

C. Emmelmann; P. Scheinemann; M. Munsch; V. Seyda

2011-01-01

283

Some considerations concerning cochlear implantation in IFACF-ORL  

PubMed Central

The article analyzes the patients who have received a cochlear implant at “Prof. Dr. Dorin Hociota” Institute of Phonoaudiology and Functional ENT Surgery, Bucharest, over a period of 13 years, from the beginning of this program in the year 2000. It presents the types of devices used, the particularities of the patients, the surgical techniques and the outcome, critically analyzing the complications encountered. The authors’ comments on the selection of patient protocol, surgical intraoperative challenges and cochlear implant technologies and capabilities are presented.

Hainarosie, M; Zainea, V; Serban, S; Georgescu, MG; Hainarosie, R; Marinescu, A; Georgescu, G

2014-01-01

284

Application of Cluster Boron Implantation to pMOSFETs  

NASA Astrophysics Data System (ADS)

We applied B18HX+ as an alternation of B+ or BF2+ to the implantation for source-drain extension in pMOSFETs corresponding to various technology nodes from 65 nm to 28 nm. We could obtain identical or better characteristics compared to the cases of conventional ions. In addition, we found from blank wafer that larger impact damage to Si atoms in B18HX+ implantation leads to more advantageous Rs-Xj in activation processing with only MSA.

Kawasaki, Y.; Ishibashi, M.; Kitazawa, M.; Maruyama, Y.; Endo, S.; Yamashita, T.; Kuroi, T.

2011-01-01

285

Scuba diving with cochlear implants.  

PubMed

We report on a patient with bilateral cochlear implants (a Med-El Combi40 and a Med-El Combi40+), as well as considerable experience in scuba diving with both of his implants. After having been exposed to 68 and 89 dives, respectively, in depths of up to 43 m, both cochlear implants are in working order and the patient continues to receive excellent speech recognition scores with both cochlear implant systems. The presented data show that scuba diving after cochlear implantation is possible over a considerable number of dives without any major negative impact on the implants. PMID:12784981

Kompis, Martin; Vibert, Dominique; Senn, Pascal; Vischer, Mattheus W; Häusler, Rudolf

2003-05-01

286

Effectiveness of implantation of a subcutaneous implantable cardioverter-defibrillator in a patient with complete heart block and a pacemaker.  

PubMed

The subcutaneous implantable cardioverter-defibrillator (S-ICD) represents an important alternative to traditional ICD therapy. The major limitation of this technology is the inability to provide pacing. Here, we present a case of a patient with complete heart block and a pacemaker who underwent placement of an S-ICD. Special considerations had to be taken with regards to evaluation and implantation of the S-ICD because of the pacemaker. In conclusion, implantation of an S-ICD can be done in patients with pacemaker effectively with appropriate electrocardiographic screening, device testing, and programming. PMID:25465940

Porterfield, Christopher; DiMarco, John P; Mason, Pamela K

2015-01-15

287

Benefits and Risks of Cochlear Implants  

MedlinePLUS

... Procedures Implants and Prosthetics Cochlear Implants Benefits and Risks of Cochlear Implants What are the Benefits of ... enjoy music. [ back to top ] What are the Risks of Cochlear Implants? General Anesthesia Risks General anesthesia ...

288

MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM--anabolic implants and meat quality.  

PubMed

Anabolic implants are routinely used in the finishing phase of beef production to improve animal performance and feed efficiency. Implanting during the feedlot phase on average increases ADG 18%, feed intake 6%, feed efficiency 8%, carcass weight 5%, and ribeye area 4% compared with nonimplanted controls. Implants reduce the cost of beef production, which is important given current high feed costs and beef prices. In a 1996 review of 37 implant trials, the use of a combination (i.e., estrogenic and trenbolone acetate) implant increased returns by US$77/head compared with nonimplanted steers. If calculated using today's prices, a combination implant would increase returns by $163/head. However, concerns about potential negative effects of implants on marbling scores, quality grades, and tenderness exist. Changes in Warner-Bratzler shear force values of steaks from implanted steers are small (<0.5 kg) and appear related to an increase in initial tenderness, possibly due to hypertrophy of muscle fiber, instead of alterations in postmortem proteolysis. The increase in ribeye size observed with implanting may also reduce marbling scores through a dilution effect. The impact of anabolic implants on gene expression has shown that implanting downregulates expression of certain lipogenic genes (e.g., stearoyl-CoA desaturase, fatty acid synthetase, fatty acid elongase-6) in steers with low quality grades (Select-) but not in implanted steers with high quality grades (Choice-). Examination of the adipocyte's transcriptome has shown that 36 genes were differentially expressed due to implant treatment. More research is needed to further determine how anabolic implants alter lipogenic gene expression to address changes in marbling deposition with implant usage. Given our current high feed costs and cattle prices, anabolic implants are one of the most cost-effective technologies that can be used in beef production systems. PMID:24243897

Duckett, S K; Pratt, S L

2014-01-01

289

Very Large Scale Plasma Source Ion Implantation  

NASA Astrophysics Data System (ADS)

Plasma Source Ion Implantation (PSII) is a technology in the process of being commercialized for the surface enhancement of industrial components.( Plasma-Based Processing of Materials for Motor Vehicle Components and Manufacturing Applications, National Institute of Standards and Technology, Advanced Technology Program, Focused Program 95-02) The process is based on the utilization of plasma sheath characteristics to accelerate and implant ions (in pulses ranging from ~ 1 ?sec to a few 10s of ?sec) into target surfaces which can be complex, composed of multiple individual components, and potentially have very large surface areas. The implanted ions (typically nitrogen, carbon, oxygen, or other species readily produced from gaseous precursors) modify the target surface characteristics to depths of ~ 1000 Åthrough the formation of hard nitrides, carbides, etc. which can have significantly better wear and corrosion properties than the base target material. PSII is capable of achieving surface property enhancements which are comparable to those obtained through more conventional beam line implantation, but with significant improvements in process time and cost for large, complex targets.(C.P. Munson, et al., Surface and Coatings Technology 84 (1996) 528-536.) Plasma, plasma sheath, and secondary electron interactions become critically important for applications involving implantation into three dimensional target assemblies composed of large numbers of individual components. In these cases, interaction of the plasma sheaths from different portions of the target assembly and interaction of the energetic secondary electrons with the plasma and background neutral gas can dramatically alter the ambient plasma conditions. The highly energetic (>= 20 keV) secondary electrons can approach densities which are 10% of the background plasma (ne ~ 1-5 × 10^8/cm^3, Te ~ 2-5 eV), leading to highly non-Maxwellian velocity distributions and accompanying plasma instabilities. Langmuir probe measurements from within such an assembly are being compared to particle-in-cell simulations of the plasma behavior during the implantation process. Results of the experimental measurements and comparison to the numerical simulations will be presented.

Munson, Carter P.

1997-11-01

290

An ECT/ERT dual-modality sensor for oil-water two-phase flow measurement  

NASA Astrophysics Data System (ADS)

This paper presents a new sensor for ECT/ERT dual-modality system which can simultaneously obtain the permittivity and conductivity of the materials in the pipeline. Quasi-static electromagnetic fields are produced by the inner electrodes array sensor of electrical capacitance tomography (ECT) system. The results of simulation show that the data of permittivity and conductivity can be simultaneously obtained from the same measurement electrode and the fusion of two kinds of data may improve the quality of the reconstructed images. For uniform oil-water mixtures, the performance of designed dual-modality sensor for measuring the various oil fractions has been tested on representative data and the results of experiments show that the designed sensor broadens the measurement range compared to single modality.

Wang, Pitao; Wang, Huaxiang; Sun, Benyuan; Cui, Ziqiang; Huang, Wenrui

2014-04-01

291

An ECT/ERT dual-modality sensor for oil-water two-phase flow measurement  

SciTech Connect

This paper presents a new sensor for ECT/ERT dual-modality system which can simultaneously obtain the permittivity and conductivity of the materials in the pipeline. Quasi-static electromagnetic fields are produced by the inner electrodes array sensor of electrical capacitance tomography (ECT) system. The results of simulation show that the data of permittivity and conductivity can be simultaneously obtained from the same measurement electrode and the fusion of two kinds of data may improve the quality of the reconstructed images. For uniform oil-water mixtures, the performance of designed dual-modality sensor for measuring the various oil fractions has been tested on representative data and the results of experiments show that the designed sensor broadens the measurement range compared to single modality.

Wang, Pitao [School of Electronic Engineering and Automation, Tianjin University, 300072 and School of Electronic Engineering, University of Jinan (China); Wang, Huaxiang; Sun, Benyuan; Cui, Ziqiang [School of Electronic Engineering and Automation, Tianjin University, 300072 (China); Huang, Wenrui [HuaDian Heavy Industries Co. Ltd, Beijing, 100077 (China)

2014-04-11

292

Application of Encapsulated Cell Technology for Retinal Degenerative Diseases  

Microsoft Academic Search

Encapsulated cell technology (ECT) is essentially a cell-based delivery system that can be used to deliver therapeutic agents\\u000a to the target tissue, including the central nervous system (CNS) and the eye to treat chronic disorders. In this chapter,\\u000a we focus on its application in retinal degenerative diseases.

Weng Tao; Rong Wen

293

Ion implantation in silicate glasses  

SciTech Connect

This review examines the effects of ion implantation on the physical properties of silicate glasses, the compositional modifications that can be brought about, and the use of metal implants to form colloidal nanosize particles for increasing the nonlinear refractive index.

Arnold, G.W.

1993-12-01

294

Characterization of the Edge Crack Torsion (ECT) Test for Mode III Fracture Toughness Measurement of Laminated Composites  

NASA Technical Reports Server (NTRS)

The edge crack torsion (ECT) test is designed to initiate mode III delamination growth in composite laminates. An ECT specimen is a rectangular laminate, containing an edge delamination at the laminate mid-plane. Torsion load is applied to the specimens, resulting in relative transverse shear sliding of the delaminated faces. The test data reduction schemes are intended to yield initiation values of critical mode III strain energy release rate, G(sub IIIc), that are constant with delamination length. The test has undergone several design changes during its development. The objective of this paper was to determine the suitability of the current ECT test design as a mode III fracture test. To this end, ECT tests were conducted on specimens manufactured from IM7/8552 and specimens made from S2/8552 tape laminates. Several specimens, each with different delamination lengths are tested. Detailed, three-dimensional finite element analyses of the specimens were performed. The analysis results were used to calculate the distribution of mode I, mode II, and mode III strain energy release rate along the delamination front. The results indicated that mode III-dominated delamination growth would be initiated from the specimen center. However, in specimens of both material types, the measured values of G(sub IIIc) exhibited significant dependence on delamination length. Furthermore, there was a large amount of scatter in the data. Load-displacement response of the specimens exhibited significant deviation from linearity before specimen failure. X-radiographs of a sample of specimens revealed that damage was initiated in the specimens prior to failure. Further inspection of the failure surfaces is required to identify the damage and determine that mode III delamination is initiated in the specimens.

Ratcliffe, James G.

2004-01-01

295

Rehabilitation using single stage implants  

PubMed Central

Implant related prosthesis has become an integral part of rehabilitation of edentulous areas. Single stage implant placement has become popular because of its ease of use and fairly predictable results. In this paper, we present a series of cases of single stage implants being used to rehabilitate different clinical situations. All the implants placed have been successfully restored and followed up for up to one year. PMID:20376239

Mohamed, Jumshad B.; Sudarsan, Sabitha; Arun, K. V.; Shivakumar, B.

2009-01-01

296

The performance of bone marrow mesenchymal stem cell--implant complexes prepared by cell sheet engineering techniques.  

PubMed

This study investigated the hypothesis that cell sheets composed of multilayered rabbit bone marrow derived mesenchymal stem cells (MSC) could be assembled with two kinds of implants (surface-modified titanium and zirconia) for the construction of a MSC-implant. The MSC sheets were harvested from culture flasks, wrapped around implants to construct the complexes, and then cultured in osteogenic medium. The layered cell sheets integrated well with implants and remained viable, with small mineralized nodules visible on the implant surfaces for up to four weeks after culture. Cells on the implants underwent classical in vitro osteogenic differentiation with an associated elevation of alkaline phosphatase activity and bone- and vascular-related protein expression. In vivo, two kinds of cell sheet-implant complexes were transplanted under the skin of SCID mice and cultured for eight weeks. For the MSC sheet titanium implant complex, histological examination revealed that new bone tissue that formed around implants followed a predominantly endochondral pathway, exhibiting histological markers of native bone; for the MSC sheet zirconia implant complex, however, intramembranous ossification appeared to occur on the surface of the zirconia implant, as observed with typical osteocytes embedded in dense matrix and accompanied by both microvessels and marrow cavities. These findings demonstrate that MSC-implants possessing osteogenic and vascularization abilities can be produced using cell sheet engineering techniques in conjunction with routine implant materials, which provide a novel technology to modify the implant surface. PMID:20132981

Zhou, Wei; Han, Chun; Song, Yingliang; Yan, Xingrong; Li, Dehua; Chai, Zhiguo; Feng, Zhihong; Dong, Yan; Li, Liwen; Xie, Xing; Chen, Fulin; Zhao, Yimin

2010-04-01

297

Characterization of the Edge Crack Torsion (ECT) Test for Mode III Fracture Toughness Measurement of Laminated Composites  

NASA Technical Reports Server (NTRS)

The edge crack torsion (ECT) test is designed to initiate mode III delamination growth in composite laminates. The test has undergone several design changes during its development. The objective of this paper was to determine the suitability of the current ECT test design a mode III fracture test. To this end, ECT tests were conducted on specimens manufactured from IM7/8552 and S2/8552 tape laminates. Three-dimensional finite element analyses were performed. The analysis results were used to calculate the distribution of mode I, mode II, and mode III strain energy release rate along the delamination front. The results indicated that mode IIIdominated delamination growth would be initiated from the specimen center. However, in specimens of both material types, the measured values of GIIIc exhibited significant dependence on delamination length. Load-displacement response of the specimens exhibited significant deviation from linearity before specimen failure. X-radiographs of a sample of specimens revealed that damage was initiated in the specimens prior to failure. Further inspection of the failure surfaces is required to identify the damage and determine that mode III delamination is initiated in the specimens.

Ratcliffe, James G.

2004-01-01

298

Developmental neuroplasticity after cochlear implantation  

E-print Network

Developmental neuroplasticity after cochlear implantation Andrej Kral1,2 and Anu Sharma3 1. Cochlear implants bypass cochlear damage by directly stimulating the auditory nerve and brain, making, and mechanistic constraints on, sensi- tive periods for cochlear implantation and describe the effects

Allen, Jont

299

Prosthetic failure in implant dentistry.  

PubMed

Although osseointegrated dental implants have become a predictable and effective modality for the treatment of single or multiple missing teeth, their use is associated with clinical complications. Such complications can be biologic, technical, mechanical, or esthetic and may compromise implant outcomes to various degrees. This article presents prosthetic complications accompanied with implant-supported single and partial fixed dental prostheses. PMID:25434566

Sadid-Zadeh, Ramtin; Kutkut, Ahmad; Kim, Hyeongil

2015-01-01

300

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation  

PubMed Central

To complete cell division with high fidelity, cytokinesis must be coordinated with chromosome segregation. Mammalian Polo-like kinase 1, Plk1, may function as a critical link because it is required for chromosome segregation and establishment of the cleavage plane following anaphase onset. A central spindle–localized pool of the RhoGEF Ect2 promotes activation of the small GTPase RhoA, which drives contractile ring assembly at the equatorial cortex. Here, we have investigated how Plk1 promotes the central spindle recruitment of Ect2. Plk1 phosphorylates the noncatalytic N terminus of the RhoGAP HsCyk-4 at the central spindle, creating a phospho-epitope recognized by the BRCA1 C-terminal (BRCT) repeats of Ect2. Failure to phosphorylate HsCyk-4 blocks Ect2 recruitment to the central spindle and the subsequent induction of furrowing. Microtubules, as well as the microtubule-associated protein (MAP) Prc1, facilitate Plk1 phosphorylation of HsCyk-4. Characterization of a phosphomimetic version of HsCyk-4 indicates that Plk1 promotes Ect2 recruitment through multiple targets. Collectively, our data reveal that formation of the HsCyk-4-Ect2 complex is subject to multiple layers of regulation to ensure that RhoA activation occurs between the segregated sister chromatids during anaphase. PMID:19468300

Wolfe, Benjamin A.; Takaki, Tohru; Petronczki, Mark; Glotzer, Michael

2009-01-01

301

Investigation of droplet distribution in electrohydrodynamic atomization (EHDA) using an ac-based electrical capacitance tomography (ECT) system with an internal-external electrode sensor  

NASA Astrophysics Data System (ADS)

Electrohydrodynamic atomization (EHDA) has recently been applied to the fabrication of polymeric micro- or nano-particles or fibres for drug encapsulation. For in situ monitoring of pharmaceutical particle fabrication in an EHDA encapsulation chamber, electrical capacitance tomography (ECT) has been used as a non-invasive measurement technique. The key achievements made during this study include the successful monitoring of very dilute droplet and particle trajectories in different regions of the EHDA encapsulation chamber. The results of both a charge/discharge ECT system and an ac-based ECT system are compared. A new type of ECT sensor with internal and external electrodes is used to improve the sensitivity of ECT measurement for detection of the objects in the central area of the EHDA encapsulation chamber. The water-air and dicholoromethane (DCM)-air systems in the dripping and spray modes have been investigated to determine the feasibility of imaging water and DCM droplets of low concentration in the encapsulation chamber using ECT.

Rezvanpour, Alireza; Wang, Chi-Hwa; Liang, Yung C.; Yang, Wuqiang

2012-01-01

302

Application of confocal laser microscopy for monitoring mesh implants in herniology  

SciTech Connect

The state of the surface of mesh implants and their encapsulation region in herniology is investigated by laser confocal microscopy. A correlation between the probability of developing relapses and the size and density of implant microdefects is experimentally shown. The applicability limits of differential reverse scattering for monitoring the post-operation state of implant and adjacent tissues are established based on model numerical experiments. (optical technologies in biophysics and medicine)

Zakharov, V P; Belokonev, V I; Bratchenko, I A; Timchenko, P E; Vavilov, A V; Volova, L T

2011-04-30

303

First Results from the Radiation Belt Storm Probes (RBSP) - Energetic particle, Composition, and Thermal plasma (ECT) Suite Science Investigation  

NASA Astrophysics Data System (ADS)

The Radiation Belt Storm Probes (RBSP) - Energetic Particle, Composition, and Thermal Plasma (ECT) suite contains a well-proven complement of particle instruments to ensure the highest quality measurements ever made in the radiation belts and the inner magnetosphere. The coordinated ECT particle measurements, analyzed in combination with fields and waves observations and state-of-the-art theory and modeling, provide new understanding on the acceleration, global distribution, and variability of radiation belt electrons and ions, key science objectives of NASA's Living With a Star program and the RBSP mission. The RBSP-ECT suite consists of three highly-coordinated instruments: the Helium Oxygen Proton Electron (HOPE) spectrometer, the Magnetic Electron Ion Spectrometer (MagEIS), and the Relativistic Electron Proton Telescope (REPT). Collectively they cover comprehensively the full electron and ion spectra from one eV to 10's of MeV with sufficient energy resolution, pitch angle coverage and resolution, and with composition measurements in the critical energy range up to 50 keV and also from a few to 50 MeV/nucleon. All three instruments are based on measurement techniques proven in the radiation belts, then optimized to provide unambiguous separation of ions and electrons and clean energy responses even in the presence of extreme penetrating background environments. In this presentation, we summarize overall ECT science questions and then show first scientific results derived from the ECT suite on the dual RBSP spacecraft. We anticipate that these results will include progress toward resolving primary RBSP science targets, such as: the relative role of localized acceleration versus transport-generated particle acceleration; the role of plasma electron temperature anisotropies, whistler waves, and radiation belt electron variability; global characteristics of outer zone electron drift loss to the magnetopause; the role of storms, substorms, and ion composition in radiation belt dynamics, both in terms of sources and sinks; new physical perspectives on inner zone and slot protons and electrons; and, how plasmasphere properties control or influence radiation belt behavior.

Spence, H. E.; Reeves, G. D.

2012-12-01

304

Risks of Breast Implants  

MedlinePLUS

... gel-filled breast implants and connective tissue disease, breast cancer, or reproductive problems. In order to rule out these and other rare complications, studies would need to be larger and longer than these ... women who undergo breast augmentation can successfully breastfeed and some cannot. Women ...

305

Implantable Drug Dispenser  

NASA Technical Reports Server (NTRS)

Drugs such as insulin are injected as needed directly into bloodstream by compact implantable dispensing unit. Two vapor cavities produce opposing forces on drug-chamber diaphragm. Heaters in cavities allow control of direction and rate of motion of bellows. Dispensing capsule fitted with coil so batteries can be recharged by induction.

Collins, E. R. J.

1983-01-01

306

Bone cement implantation syndrome  

Microsoft Academic Search

Bone cement implantation syndrome (BCIS) is characterised by hypotension, hypoxaemia, cardiac arrhythmias, cardiac arrest or any combination of these, leading to death in 0.6–1% of patients. One of the mechanisms suggested to explain these complications is diffuse microembolisation of the lungs as a consequence of extrusion of the bone marrow content by the pressurised bone cement. By reducing intramedullary pressure

W. R. Lamadé; W. Friedl; B. Schmid; P. J. Meeder

1995-01-01

307

Elementary Implantable Force Sensor  

PubMed Central

Implementing implantable sensors which are robust enough to maintain long term functionality inside the body remains a significant challenge. The ideal implantable sensing system is one which is simple and robust; free from batteries, telemetry, and complex electronics. We have developed an elementary implantable sensor for orthopaedic smart implants. The sensor requires no telemetry and no batteries to communicate wirelessly. It has no on-board signal conditioning electronics. The sensor itself has no electrical connections and thus does not require a hermetic package. The sensor is an elementary L-C resonator which can function as a simple force transducer by using a solid dielectric material of known stiffness between two parallel Archimedean coils. The operating characteristics of the sensors are predicted using a simplified, lumped circuit model. We have demonstrated sensor functionality both in air and in saline. Our preliminary data indicate that the sensor can be reasonably well modeled as a lumped circuit to predict its response to loading. PMID:24883335

Wachs, Rebecca A.; Ellstein, David; Drazan, John; Healey, Colleen P.; Uhl, Richard L.; Connor, Kenneth A.

2014-01-01

308

[Cochlear implants and tinnitus].  

PubMed

The cochlear implant became a very successful method of hearing rehabilitation for patients with profound sensorineural hearing loss. The benefits of the CI extend beyond the medical success and positively influence social and psychosocial areas, reflected by an improved HRQoL. Furthermore, variety of studies demonstrated that the tinnitus severity improves in 46-95?% of cases following the cochlear implantation. However, the parameters investigated in such studies are not always standardized or addressed by validated questionnaires, which explains the high outcome variation between the studies. The relationships between HRQoL and tinnitus distress before and after cochlear implantation have not been well studied. Nevertheless, it is believed that the improvement in HRQoL following CI affects particularly tinnitus.However, an existing tinnitus can also worsen or occur for the first time after the surgery. Since neither tinnitus frequency nor tinnitus loudness correlate with the tinnitus-induced distress, the measurement of HRQoL, distress factors, stress reactions and psychiatric comorbidities appears to be the meaningful assessment of positive or negative effects of CI on tinnitus.Initial studies demonstrated that also patients with unilateral hearing loss may benefit from CI supply, as shown by an improvement in HRQoL and reduction of tinnitus-induced distress. For those patients, who despite CI implantation experience severe tinnitus, there is an option of tinnitus-specific CI-fitting and tinnitus-specific therapy with psychosomatic and psychological approaches, and- in addition- a treatment of possible mental comorbidities. PMID:25862623

Olze, H

2015-04-01

309

Biodegradable Orthopedic Implants  

Microsoft Academic Search

Over the past 30 years, there have been significant advances in the development of biodegradable materials [79]. In particular, these materials have received attention for use as implants to aid regeneration of orthopedic defects [49,91]. Every year more than 3.1 million orthopedic surgeries are performed in the United States alone [1]. However, although current treatments using nondegradable fixation materials have

Johnna S. Temenoff; Antonios G. Mikos

310

Implantable electrical device  

NASA Technical Reports Server (NTRS)

A fully implantable and self contained device is disclosed composed of a flexible electrode array for surrounding damaged nerves and a signal generator for driving the electrode array with periodic electrical impulses of nanoampere magnitude to induce regeneration of the damaged nerves.

Jhabvala, M. D. (inventor)

1982-01-01

311

Implantable intravenous access device.  

PubMed Central

The use of a fully implantable device for venous access is described in two infants with transfusion dependent haemolytic anaemia. This device is a possible improvement in the treatment of infants needing long term venous access, although doctors should be aware of the infrequent complications. Images p131-a PMID:1739327

Goldsworthy, L L; Daly, H M

1992-01-01

312

The Development of the Nucleus® Freedom™ Cochlear Implant System  

PubMed Central

Cochlear Limited (Cochlear™) released the fourth-generation cochlear implant system, Nucleus® Freedom™, in 2005. Freedom is based on 25 years of experience in cochlear implant research and development and incorporates advances in medicine, implantable materials, electronic technology, and sound coding. This article presents the development of Cochlear's implant systems, with an overview of the first 3 generations, and details of the Freedom system: the CI24RE receiver-stimulator, the Contour Advance™ electrode, the modular Freedom processor, the available speech coding strategies, the input processing options of SmartSound™ to improve the signal before coding as electrical signals, and the programming software. Preliminary results from multicenter studies with the Freedom system are reported, demonstrating better levels of performance compared with the previous systems. The final section presents the most recent implant reliability data, with the early findings at 18 months showing improved reliability of the Freedom implant compared with the earlier Nucleus 3 System. Also reported are some of the findings of Cochlear's collaborative research programs to improve recipient outcomes. Included are studies showing the benefits from bilateral implants, electroacoustic stimulation using an ipsilateral and/or contralateral hearing aid, advanced speech coding, and streamlined speech processor programming. PMID:17172547

Patrick, James F.; Busby, Peter A.; Gibson, Peter J.

2006-01-01

313

A novel strategy for long-term implantable artificial pancreas.  

PubMed

Technology has recently changed type 1 diabetes treatment by introducing several advancements able to improve patients' quality of life. However, despite of several decades of research efforts, the dream of a fully-automated implanted artificial pancreas is quite far from its realization. The need for periodically restoring the implanted battery charge and refilling the implanted insulin reservoir are the main issues, for which invasive surgery, transcutaneous catheters or external portable devices are presently the only solutions. In this paper we propose a novel approach to these issues, describing a totally implanted closed-loop artificial pancreas with a wireless battery charger and a non-invasive strategy for insulin refilling, based on sensorized swallowable "insulin carrier" capsules. Such system has the potential to represent a final solution for diabetes treatment, by fully restoring patients' quality of life. PMID:22254935

Ricotti, Leonardo; Assaf, Tareq; Menciassi, Arianna; Dario, Paolo

2011-01-01

314

Industrial applications of ion implantation into metal surfaces  

SciTech Connect

The modern materials processing technique, ion implantation, has intriguing and attractive features that stimulate the imaginations of scientists and technologists. Success of the technique for introducing dopants into semiconductors has resulted in a stable and growing infrastructure of capital equipment and skills for use of the technique in the economy. Attention has turned to possible use of ion implantation for modification of nearly all surface related properties of materials - optical, chemical and corrosive, tribological, and several others. This presentation provides an introduction to fundamental aspects of equipment, technique, and materials science of ion implantation. Practical and economic factors pertaining to the technology are discussed. Applications and potential applications are surveyed. There are already available a number of ion-implanted products, including ball-and-roller bearings and races, punches-and-dies, injection screws for plastics molding, etc., of potential interest to the machine tool industry.

Williams, J.M.

1987-07-01

315

Engineering single photon emitters by ion implantation in diamond.  

PubMed

Diamond provides unique technological platform for quantum technologies including quantum computing and communication. Controlled fabrication of optically active defects is a key element for such quantum toolkit. Here we report the production of single color centers emitting in the blue spectral region by high energy implantation of carbon ions. We demonstrate that single implanted defects show sub-poissonian statistics of the emitted photons and can be explored as single photon source in quantum cryptography. Strong zero phonon line at 470.5 nm allows unambiguous identification of this defect as interstitial-related TR12 color center. PMID:19956415

Naydenov, B; Kolesov, R; Batalov, A; Meijer, J; Pezzagna, S; Rogalla, D; Jelezko, F; Wrachtrup, J

2009-11-01

316

SEM analysis of ion implanted SiC  

NASA Astrophysics Data System (ADS)

SiC is a material used in two future energy production technologies, firstly as a photovoltaic layer to harness the UV spectrum in high efficient power solar cells, and secondly as a diffusion barrier material for radioactive fission products in the fuel elements of the next generation of nuclear power plants. For both applications, there is an interest in the implantation of reactive and non-reactive ions into SiC and their effects on the properties of the SiC. In this study 360 keV Ag+, I+ and Xe+ ions were separately implanted into 6H-SiC and in polycrystalline SiC at various substrate temperatures. The implanted samples were also annealed in vacuum at temperatures ranging from 900 °C to 1600 °C for various times. In recent years, there had been significant advances in scanning electron microscopy (SEM) with the introduction of an in-lens detector combined with field emission electron guns. This allows defects in solids, such as radiation damage created by the implanted ions, to be detected with SEM. Cross-sectional SEM images of 6H-SiC wafers implanted with 360 keV Ag+ ions at room temperature and at 600 °C and then vacuum annealed at different temperatures revealed the implanted layers and their thicknesses. A similar result is shown of 360 keV I+ ions implanted at 600 °C into 6H-SiC and annealed at 1600 °C. The 6H-SiC is not amorphized but remained crystalline when implanting at 600 °C. There are differences in the microstructure of 6H-SiC implanted with silver at the two temperatures as well as with reactive iodine ions. Voids (bubbles) are created in the implanted layers into which the precipitation of silver and iodine can occur after annealing of the samples. The crystallinity of the substrate via implantation temperature caused differences in the distribution and size of the voids. Implantation of xenon ions in polycrystalline SiC at 350 °C does not amorphize the substrate as is the case with room temperature heavy ion bombardment. Subsequent annealing of the implanted polycrystalline samples leads to increased thermal etching effects such as grain boundary grooving. Damage due to channelling (or non-channelling) in the different crystallites resulted also in differences in thermal etching in the crystallites.

Malherbe, Johan B.; van der Berg, N. G.; Botha, A. J.; Friedland, E.; Hlatshwayo, T. T.; Kuhudzai, R. J.; Wendler, E.; Wesch, W.; Chakraborty, P.; da Silveira, E. F.

2013-11-01

317

iCARDEA: Practical data integration for the follow-up of Cardiovascular Implantable Electronic Device patients in cardiology departments  

Microsoft Academic Search

In cardiology departments supporting implantation and follow-up of Cardiovascular Implantable Electronic Devices (CIED), relevant clinical data reside in autonomous healthcare information systems that support different health information technology (HIT) standards and proprietary data formats. Each organization chooses the Electronic Health Record (EHR) integration solutions, underlying technologies, and HIT standards based on their needs, experience and budget. However, without efficient data

Maohua Yang; Catherine E. Chronaki; Christian Lupkes; Andreas Thiel; Manuela Plosnig; Lynne Hinterbuchner; Elena Arbelo; Asuman Dogac; Marco Eichelberg; Andreas Hein

2011-01-01

318

Biphasic electrical current stimulator for early bone formation in dental implant  

Microsoft Academic Search

Since the discovery of piezoelectric properties of natural bone, electrical stimulation has been widely used in the clinical treatment of orthopedic fracture. Nevertheless, in dental implant technologies, it is the methods of surface modification that has been recently developed to enhance early osteointegration between implant's surface and surrounding tissue. In this paper, in order to accelerate bone formation, we developed

Jong Keun Song; Sung June Kim

319

Entertainment Television and Hearing Students' Attitudes Regarding the Pediatric Cochlear Implant  

Microsoft Academic Search

The cochlear implant, a bionic technology that restores sound sensation in some patients, has become ethically controversial in the 20 years since its introduction. This controversy recently has entered American entertainment culture, with the issue of pediatric implants emerging in episodes of popular TV programs. This pilot study examines the effects of one such TV episode on the attitudes of

Katrina R. Miller; Kathy Wheeler-Scruggs

2002-01-01

320

Bronchoscopic Implantation of a Novel Wireless Electromagnetic Transponder in the Canine Lung: A Feasibility Study  

Microsoft Academic Search

Purpose: The success of targeted radiation therapy for lung cancer treatment is limited by tumor motion during breathing. A real-time, objective, nonionizing, electromagnetic localization system using implanted electromagnetic transponders has been developed (Beacon electromagnetic transponder, Calypso Medical Technologies, Inc., Seattle, WA). We evaluated the feasibility and fixation of electromagnetic transponders bronchoscopically implanted in small airways of canine lungs and compared

Martin L. Mayse; Parag J. Parikh; Kristen M. Lechleiter; Steven Dimmer; Mia Park; Amir Chaudhari; Michael Talcott; Daniel A. Low; Jeffrey D. Bradley

2008-01-01

321

Bored By Non-Glowing Skin? Ultra-Flexible, Waterproof LED Implants Are What You Seek  

E-print Network

Bored By Non-Glowing Skin? Ultra-Flexible, Waterproof LED Implants Are What You Seek By Alasdair Wilkins/io9 Posted 10.19.2010 at 12:15 pm LED Lights Could Be Implanted Under Skin Photo courtesy of iO9 LEDs are, on small scales, the cheapest, most reliable, and most technologically powerful light sources

Rogers, John A.

322

Automatic Frequency Controller for Power Amplifiers Used in Bio-Implanted Applications: Issues and Challenges  

PubMed Central

With the development of communication technologies, the use of wireless systems in biomedical implanted devices has become very useful. Bio-implantable devices are electronic devices which are used for treatment and monitoring brain implants, pacemakers, cochlear implants, retinal implants and so on. The inductive coupling link is used to transmit power and data between the primary and secondary sides of the biomedical implanted system, in which efficient power amplifier is very much needed to ensure the best data transmission rates and low power losses. However, the efficiency of the implanted devices depends on the circuit design, controller, load variation, changes of radio frequency coil's mutual displacement and coupling coefficients. This paper provides a comprehensive survey on various power amplifier classes and their characteristics, efficiency and controller techniques that have been used in bio-implants. The automatic frequency controller used in biomedical implants such as gate drive switching control, closed loop power control, voltage controlled oscillator, capacitor control and microcontroller frequency control have been explained. Most of these techniques keep the resonance frequency stable in transcutaneous power transfer between the external coil and the coil implanted inside the body. Detailed information including carrier frequency, power efficiency, coils displacement, power consumption, supplied voltage and CMOS chip for the controllers techniques are investigated and summarized in the provided tables. From the rigorous review, it is observed that the existing automatic frequency controller technologies are more or less can capable of performing well in the implant devices; however, the systems are still not up to the mark. Accordingly, current challenges and problems of the typical automatic frequency controller techniques for power amplifiers are illustrated, with a brief suggestions and discussion section concerning the progress of implanted device research in the future. This review will hopefully lead to increasing efforts towards the development of low powered, highly efficient, high data rate and reliable automatic frequency controllers for implanted devices. PMID:25615728

Hannan, Mahammad A.; Hussein, Hussein A.; Mutashar, Saad; Samad, Salina A.; Hussain, Aini

2014-01-01

323

Bone Substitutes for Peri-Implant Defects of Postextraction Implants  

PubMed Central

Placement of implants in fresh sockets is an alternative to try to reduce physiological resorption of alveolar ridge after tooth extraction. This surgery can be used to preserve the bone architecture and also accelerate the restorative procedure. However, the diastasis observed between bone and implant may influence osseointegration. So, autogenous bone graft and/or biomaterials have been used to fill this gap. Considering the importance of bone repair for treatment with implants placed immediately after tooth extraction, this study aimed to present a literature review about biomaterials surrounding immediate dental implants. The search included 56 articles published from 1969 to 2012. The results were based on data analysis and discussion. It was observed that implant fixation immediately after extraction is a reliable alternative to reduce the treatment length of prosthetic restoration. In general, the biomaterial should be used to increase bone/implant contact and enhance osseointegration. PMID:24454377

Santos, Pâmela Letícia; Gulinelli, Jéssica Lemos; Telles, Cristino da Silva; Betoni Júnior, Walter; Chiacchio Buchignani, Vivian; Queiroz, Thallita Pereira

2013-01-01

324

The socially constructed breast: breast implants and the medical construction of need.  

PubMed Central

When silicone gel breast implants became the subject of a public health controversy in the early 1990s, the most pressing concern was safety. This paper looks at another, less publicized issue: the need for implants. Using a symbolic interactionist approach, the author explores the social construction of the need for implants by tracing the history of the 3 surgical procedures for which implants were used. Stakeholders in this history constructed need as legitimized individual desire, the form of which shifted with changes in the technological and social context. PMID:9702166

Jacobson, N

1998-01-01

325

Effects of surface preparation on ion implantation in GaAs  

NASA Astrophysics Data System (ADS)

The influence of different polishing methods on the atomic profiles obtained by direct ion implantation in semi-insulating GaAs has been investigated, along with the effects of preimplantation etching. The results indicate that chem-mechanical polishing technologies, contrary to chemical only polishes, produce residual damage that results in shallower and more sharply peaked profiles. Polishing related damage, however, may not be the factor preventing a good electrical activation of implanted species. The acidity of the polishing fluid seems more important in determining the activation. Also, the dose implanted in uncapped, damaged wafers seems to be different, and generally lower, than the dose measured by the implanter.

Dobrilla, P.

1990-03-01

326

The breast implant controversy.  

PubMed

The breast implant issue is a "bad news/good news" story. For many women with implants, the controversy has caused a fair degree of anxiety which may or may not be resolved as further information becomes available. It has also taken its toll on Dow Corning. Whole lines of medical products have been eliminated or are being phase out. The development of new medical applications has been terminated. As a consequence, employees have lost their jobs. What the effect will be on the biomedical industry as a whole remains to be seen (11). While silicones have been an important component in various medical devices, it is likely that other materials can be used as replacements. However, suppliers of non-silicone materials are also reevaluating their role in this market. For example, Du Pont, the nation's largest chemical company, has determined that the unpredictable and excessive costs of doing business with manufacturers of implantable medical devices no longer justifies the unrestricted sale of standard raw materials into this industry. Other companies are quietly following suit. On the up side, it is possible that the research being driven by this controversy will result in a greater understanding of the immunologic implications of xenobiotics, of the importance of nonbiased observations, of the need for ready access to valid data sets, and of the opportunity for valid scientific information to guide legal decisions. Only time will tell. PMID:8129770

Cook, R R; Harrison, M C; LeVier, R R

1994-02-01

327

Validation of implant stability: a measure of implant permanence.  

PubMed

Implant stability is a requisite characteristic of osseointegration. Without it, long-term success cannot be achieved. Continuous monitoring in a quantitative and objective manner is important to determine the status of implant stability. Measurement of implant stability is a valuable tool for making decisions pertaining to treatment protocol and also improves dentist-patient communication. Owing to the invasive nature of histological analysis, various others methods have been proposed like radiographs, cutting torque resistance, reverse torque, modal analysis, resonance frequency analysis and Implatest® . This review focuses on objectives and various methods to evaluate implant stability. PMID:22048589

Mall, Neha; Dhanasekar, B; Aparna, I N

2011-01-01

328

Evaluation of the Edge Crack Torsion (ECT) Test for Mode 3 Interlaminar Fracture Toughness of Laminated Composites  

NASA Technical Reports Server (NTRS)

An analytical and experimental investigation was carried out on G40-800/R6376 graphite epoxy laminates to evaluate the Edge Crack Torsion (ECT) test as a candidate for a standard Mode 3 interlaminar fracture toughness test for laminated composites. The ECT test consists of a (90/(+/- 45)(sub 3)/(+/- 45)(sub 3)/90))(sub s) laminate with a delamination introduced by a non-adhesive film at the mid-plane along one edge and loaded in a special fixture to create torsion along the length of the laminate. Dye penetrate enhanced X-radiograph of failed specimens revealed that the delamination initiated at the middle of the specimen length and propagated in a self similar manner along the laminate mid-plane. A three-dimensional finite element analysis was performed that indicated that a pure Mode 3 delamination exists at the middle of specimen length away from both ends. At the ends near the loading point a small Mode 2 component exists. However, the magnitude of this Mode 2 strain energy release rate at the loading point is small compared to the magnitude of Mode 3 component in the mid-section of the specimen. Hence, the ECT test yielded the desired Mode 3 delamination. The Mode 3 fracture toughness was obtained from a compliance calibration method and was in good agreement with the finite element results. Mode 2 End-Notched Flexure (ENF) tests and Mode 1 Double Cantilever Beam (DCB) tests were also performed for the same composite material. The Mode 1 fracture toughness was much smaller than both the Mode 2 and Mode 3 fracture toughness. The Mode 2 fracture toughness was found to be 75% of the Mode 3 fracture toughness.

Li, Jian; Lee, Edward W.; OBrien, T. Kevin; Lee, Shaw Ming

1996-01-01

329

Chromosomal localization of the human ECT2 proto-oncogene to 3q26.1 {yields} q26.2 by somatic cell analyses and fluorescence in situ hybridization  

SciTech Connect

The mouse ect2 oncogene was identified in a search of mitogenic signal transducers using a novel expression cloning strategy. In this system, the introduction of an appropriate expression-cDNA library prepared from the mRNA of one cell type into another can result in the morphological transformation of the recipient cells. The predicted Ect2 protein has sequence similarity within a central core of 255 amino acids to the products of the breakpoint-cluster gene, bcr, the yeast cell cycle gene, CDC24, the dbl and vav oncogenes, and the RasGrf gene. Baculovirus-expressed Ect2 protein shows specific binding to Rho and Rac proteins, indicating that Ect2 is a new member of transforming proteins that can interact with Rho-like proteins of the Ras superfamily. The ect2 foci exhibit an unusual stellate morphology and are capable of forming tumors when subcutaneously inoculated in nude mice. These results indicate that the ect2 gene acts as an oncogene. To investigate the involvement of the ect2 in human tumors, the authors isolated the human homolog, ECT2, of mouse ect2 and determined its chromosomal localization. 13 refs., 1 fig.

Takai, Setsuo; Yamada, Kiyomi [International Medical Center of Japan, Tokyo (Japan)] [International Medical Center of Japan, Tokyo (Japan); Long, J.E. [National Cancer Institute, Bethesda, MD (United States)] [and others] [National Cancer Institute, Bethesda, MD (United States); and others

1995-05-01

330

Electrical capacitance tomography (ECT) and gamma radiation meter for comparison with and validation and tuning of computational fluid dynamics (CFD) modeling of multiphase flow  

NASA Astrophysics Data System (ADS)

The electrical capacitance tomographic (ECT) approach is increasingly seen as attractive for measurement and control applications in the process industries. Recently, there is increased interest in using the tomographic details from ECT for comparing with and validating and tuning CFD models of multiphase flow. Collaboration with researchers working in the field of computational fluid dynamics (CFD) modeling of multiphase flows gives valuable information for both groups of researchers in the field of ECT and CFD. By studying the ECT tomograms of multiphase flows under carefully monitored inflow conditions of the different media and by obtaining the capacitance values, C(i, j, t) with i = 1…N, j = 1,?2,…N and i ? j obtained from ECT modules with N electrodes, it is shown how the interface heights in a pipe with stratified flow of oil and air can be fruitfully compared to the values of those obtained from ECT and gamma radiation meter (GRM) for improving CFD modeling. Monitored inflow conditions in this study are flow rates of air, water and oil into a pipe which can be positioned at varying inclinations to the horizontal, thus emulating the pipelines laid in subsea installations. It is found that ECT-based tomograms show most of the features seen in the GRM-based visualizations with nearly one-to-one correspondence to interface heights obtained from these two methods, albeit some anomalies at the pipe wall. However, there are some interesting features the ECT manages to capture: features which the GRM or the CFD modeling apparently do not show, possibly due to parameters not defined in the inputs to the CFD model or much slower response of the GRM. Results presented in this paper indicate that a combination of ECT and GRM and preferably with other modalities with enhanced data fusion and analysis combined with CFD modeling can help to improve the modeling, measurement and control of multiphase flow in the oil and gas industries and in the process industries in general. This article was invited for the special feature on Imaging Systems and Techniques 2012, published in July 2013.

Pradeep, Chaminda; Yan, Ru; Vestøl, Sondre; Melaaen, Morten C.; Mylvaganam, Saba

2014-07-01

331

MED-EL Cochlear Implants: State of the Art and a Glimpse Into the Future  

PubMed Central

Cochlear implantation is an accepted treatment method for adults and children with severe to profound hearing loss. Confidence in technology has led to changes in individuals who can receive a cochlear implant and changes in expected benefit with a cochlear implant. This article describes the research and development activities at MED-EL, which make possible the implementation of new speech-coding strategies as well as the application of acoustic and electric stimulation via a combined speech processor in MED-EL devices. Research on benefits from bilateral cochlear implantation and electric-acoustic stimulation are also reviewed. Finally, the potential of drug delivery systems is considered as a way to improve cochlear implant outcomes, and results from preliminary evaluations of a hybrid cochlear implant system with drug delivery capabilities are reported. PMID:17172548

Hochmair, Ingeborg; Nopp, Peter; Jolly, Claude; Schmidt, Marcus; Schößer, Hansjörg; Garnham, Carolyn; Anderson, Ilona

2006-01-01

332

Comparison of models for the calculation of ion implantation moments of implanted boron, phosphorus and arsenic dopants in thin film silicides  

NASA Astrophysics Data System (ADS)

The accurate prediction of dopant ion implantation profiles both before and after thermal processing is becoming increasingly critical in the design of ultra-large scale integration (ULSI) sub-micron devices. In this paper, the ion implantation moments of boron, phosphorus and arsenic dopants implanted into thin film titanium, tungsten and cobalt suicides are calculated using Monte Carlo, Boltzmann transport equation and look-up table approaches. Four ion implantation simulators are evaluated: the TRansport of Ions in Matter (TRIM89) Monte Carlo code, RAMM and SUPREM-3 transport equation codes and PREDICT-1.4 which relies on look-up tables for its calculations. Theoretical results are subsequently compared with experimentally measured boron, phosphorus and arsenic range and straggle parameters in thermally reacted titanium silicide thin films obtained using secondary ion mass spectroscopy (SIMS) and Rutherford backscattering spectrometry (RBS). Ion implantation energies were varied from 20 keV to 160 keV. It is demonstrated that SUPREM-3 and PREDICT-1,4 ion implantation codes do not at the present time accurately calculate the ion implantation moments of dopants implanted into the suicides investigated. However the overall correlation between TRIM, RAMM and the experimental data presented is very good. The ion implantation models in TRIM and RAMM could be employed as preprocessors in a more general ULSI sub-micron process simulator capable of modelling a doped silicide fabrication technology.

Cole, P. D.; Crean, G. M.; Lorenz, J.; Dupas, L.

1991-04-01

333

Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia: A Pilot Study  

PubMed Central

Objective. To evaluate leukocyte gene expression for 9 selected genes (mRNAs) as biological markers in patients with medication refractory depression before and after treatment with ECT or isoflurane anesthesia (ISO). Methods. In a substudy of a nonrandomized open-label trial comparing effects of ECT to ISO therapy, blood samples were obtained before and after treatment from 22 patients with refractory depression, and leukocyte mRNA was assessed by quantitative PCR. Patients' mRNAs were also compared to 17 healthy controls. Results. Relative to controls, patients before treatment showed significantly higher IL10 and DBI and lower ADRA2A and ASIC3 mRNA (P < 0.025). Both ECT and ISO induced significant decreases after treatment in 4 genes: IL10, NR3C1, DRD4, and Sult1A1. After treatment, patients' DBI, ASIC3, and ADRA2A mRNA remained dysregulated. Conclusion. Significant differences from controls and/or significant changes after ECT or ISO treatment were observed for 7 of the 9 mRNAs studied. Decreased expression of 4 genes after effective treatment with either ECT or ISO suggests possible overlap of underlying mechanisms. Three genes showing dysregulation before and after treatment may be trait-like biomarkers of medication refractory depression. Gene expression for these patients has the potential to facilitate diagnosis, clarify pathophysiology, and identify potential biomarkers for treatment effects. PMID:24826212

Iacob, E.; Tadler, S. C.; Light, K. C.; Weeks, H. R.; Smith, K. W.; White, A. T.; Hughen, R. W.; VanHaitsma, T. A.; Bushnell, L. A.; Light, A. R.

2014-01-01

334

Technologies Technologies  

E-print Network

.delbos@univ-bpclermont.fr UFR Sciences et Technologies Université Blaise Pascal 24 avenue des Landais BP 80026 63171 AUBIERE Sciences et Technologies Université Blaise Pascal 24 avenue des Landais BP 80026 63171 AUBIERE Cedex Tel Corpusculaire ­ IN2P3 UFR Sciences et Technologies Université Blaise Pascal 24 avenue des Landais BP 80026 63171

Sart, Remi

335

Implant biomaterials: A comprehensive review  

PubMed Central

Appropriate selection of the implant biomaterial is a key factor for long term success of implants. The biologic environment does not accept completely any material so to optimize biologic performance, implants should be selected to reduce the negative biologic response while maintaining adequate function. Every clinician should always gain a thorough knowledge about the different biomaterials used for the dental implants. This article makes an effort to summarize various dental bio-materials which were used in the past and as well as the latest material used now. PMID:25610850

Saini, Monika; Singh, Yashpal; Arora, Pooja; Arora, Vipin; Jain, Krati

2015-01-01

336

Implant biomaterials: A comprehensive review.  

PubMed

Appropriate selection of the implant biomaterial is a key factor for long term success of implants. The biologic environment does not accept completely any material so to optimize biologic performance, implants should be selected to reduce the negative biologic response while maintaining adequate function. Every clinician should always gain a thorough knowledge about the different biomaterials used for the dental implants. This article makes an effort to summarize various dental bio-materials which were used in the past and as well as the latest material used now. PMID:25610850

Saini, Monika; Singh, Yashpal; Arora, Pooja; Arora, Vipin; Jain, Krati

2015-01-16

337

Graphene synthesis by ion implantation  

PubMed Central

We demonstrate an ion implantation method for large-scale synthesis of high quality graphene films with controllable thickness. Thermally annealing polycrystalline nickel substrates that have been ion implanted with carbon atoms results in the surface growth of graphene films whose average thickness is controlled by implantation dose. The graphene film quality, as probed with Raman and electrical measurements, is comparable to previously reported synthesis methods. The implantation synthesis method can be generalized to a variety of metallic substrates and growth temperatures, since it does not require a decomposition of chemical precursors or a solvation of carbon into the substrate. PMID:21124725

Garaj, Slaven; Hubbard, William; Golovchenko, J. A.

2010-01-01

338

Esthetic failure in implant dentistry.  

PubMed

The definition of failure for dental implants has evolved from lack of osseointegration to increased concern for other aspects, such as esthetics. However, esthetic failure in implant dentistry has not been well defined. Although multiple esthetic indices have been validated for objectively evaluating clinical outcomes, including failure of an implant-supported crown, only one author has determined a failure threshold. On the basis of objective indices, esthetic failures in implant dentistry can be categorized as pink-tissue failures and white-tissue failures. This article discusses esthetic failures, the factors involved in these failures, and their prevention and treatment. PMID:25434568

Fuentealba, Rodrigo; Jofré, Jorge

2015-01-01

339

Implantable medical devices MRI safe.  

PubMed

Pacemakers, ICDs, neurostimulators like deep brain stimulator electrodes, spiral cord stimulators, insulin pumps, cochlear implants, retinal implants, hearing aids, electro cardio gram (ECG) leads, or devices in interventional MRI such as vascular guide wires or catheters are affected by MRI magnetic and electromagnetic fields. Design of MRI Safe medical devices requires computer modeling, bench testing, phantom testing, and animal studies. Implanted medical devices can be MRI unsafe, MRI conditional or MRI safe (see glossary). In the following paragraphs we will investigate how to design implanted medical devices MRI safe. PMID:23739365

Dal Molin, Renzo; Hecker, Bertrand

2013-01-01

340

Dissolved Oxygen Measurements in Aquatic Environments: The Eff ects of Changing Temperature and Pressure on Three Sensor Technologies  

Microsoft Academic Search

Dissolved oxygen (DO) is probably the most important parameter related to water quality and biological habitat in aquatic environments. In situ DO sensors are some of the most valuable tools used by scientists and engineers for the evaluation of water quality in aquatic ecosystems. Presently, we cannot accurately measure DO concentrations under variable temperature and pressure conditions. Pressure and temperature

Corey D. Markfort; Miki Hondzo

2009-01-01

341

Emergency delivery of Vasopressin from an implantable MEMS rapid drug delivery device  

E-print Network

An implantable rapid drug delivery device based on micro-electro-mechanical systems (MEMS) technology was designed, fabricated and validated for the in vivo rapid delivery of vasopressin in a rabbit model. In vitro ...

Ho Duc, Hong Linh, 1978-

2009-01-01

342

An Implantable MEMS Drug Delivery Device for Rapid Delivery in Ambulatory Emergency Care  

E-print Network

We introduce the first implantable drug delivery system based on MEMS (Micro-Electro-Mechanical-Systems) technology specifically designed as a platform for treatment in ambulatory emergency care. The device is named ...

Elman, Noel

343

Implanted p+n-Junctions in Silicon Carbide  

SciTech Connect

Ion implantation is considered a key technology for the realisation of silicon carbide electronic devices. Here we will give an overview of the field and present some recent results of ion implanted 4H SiC epitaxial layers. Mainly Al ions of keV energies have been used at different fluence, flux and target temperature. The samples have been investigated by secondary ion mass spectrometry (SIMS), channeling Rutherford backscattering (RBS-c) and transmission electron microscopy (TEM), both as-implanted and after annealing up to 1900 deg. C. Also the electrical activation of Al-implanted and annealed material has been investigated by scanning spreading resistance microscopy (SSRM). The damage accumulation, monitored by RBS-c, is linear with ion fluence but depends strongly on implantation temperature and ion flux. Annealing at temperatures above 1700 deg. C is needed to remove the damage and to electrically activate implanted Al ions. At these high annealing temperatures, however, dislocation loops are formed that have a negative influence on device performance.

Hallen, A.; Janson, M.S.; Osterman, J.; Zimmermann, U.; Linnarsson, M. [Dept. of Microelectronics and Information Technology, Royal Inst. of Technology, P.O. Box Electrum 229, SE 164 40 Kista (Sweden); Kuznetsov, A.; Svensson, B.G. [Physics Dept., Physical Electronics, University of Oslo, PB 1048, Blindern, N 0316 Oslo (Norway); Zhang, Y. [Div. of Ion Physics, A ring ngstroem Laboratory, Uppsala University, P.O. Box 534, SE 751 21 Uppsala (Sweden); Persson, P.O.A. [Thin Film Physics Div., Dept. of Physics, Linkoeping University, SE 581 83 Linkoeping (Sweden)

2003-08-26

344

Development of Implantable Medical Devices: From an Engineering Perspective  

PubMed Central

From the first pacemaker implant in 1958, numerous engineering and medical activities for implantable medical device development have faced challenges in materials, battery power, functionality, electrical power consumption, size shrinkage, system delivery, and wireless communication. With explosive advances in scientific and engineering technology, many implantable medical devices such as the pacemaker, cochlear implant, and real-time blood pressure sensors have been developed and improved. This trend of progress in medical devices will continue because of the coming super-aged society, which will result in more consumers for the devices. The inner body is a special space filled with electrical, chemical, mechanical, and marine-salted reactions. Therefore, electrical connectivity and communication, corrosion, robustness, and hermeticity are key factors to be considered during the development stage. The main participants in the development stage are the user, the medical staff, and the engineer or technician. Thus, there are three different viewpoints in the development of implantable devices. In this review paper, considerations in the development of implantable medical devices will be presented from the viewpoint of an engineering mind. PMID:24143287

2013-01-01

345

A remotely powered implantable biomedical system with location detector.  

PubMed

An universal remote powering and communication system is presented for the implantable medical devices. The system be interfaced with different sensors or actuators. A mobile external unit controls the operation of the implantable chip and reads the sensor's data. A locator system is proposed to align the mobile unit with the implant unit for the efficient magnetic power transfer. The location of the implant is detected with 6 mm resolution from the rectified voltage level at the implanted side. The rectified voltage level is fedback to the mobile unit to adjust the magnetic field strength and maximize the efficiency of the remote powering system. The sensor's data are transmitted by using a free running oscillator modulated with on-off key scheme. To tolerate large data carrier drifts, a custom designed receiver is implemented for the mobile unit. The circuits have been fabricated in 0.18 um CMOS technology. The remote powering link is optimized to deliver power at 13.56 MHz. On chip voltage regulator creates 1.8 V from a 0.9 V reference voltage to supply the sensor/actuator blocks. The implantable chip dissipates 595 ?W and requires 1.48 V for start up. PMID:24988596

Kilinc, Enver G; Ghanad, Mehrdad A; Maloberti, Franco; Dehollain, Catherine

2015-02-01

346

Bilateral cochlear implantation—9-year results  

Microsoft Academic Search

The topic about the patients benefit of bilateral cochlear implantation still causes a controversial discussion. We report about our experience of bilateral cochlear implantation and the importance of bilateral cochlear implantation in meningitis deafened patients.

W. D. Baumgartner; A. Jappel; K. Frei; M. Stach; J. Eckl-Dorna; J. Hamzavi

2004-01-01

347

Microstructural characterization of iron implanted sapphire nanocomposites  

SciTech Connect

Nanocomposites of iron in sapphire ({alpha}-Al{sub 2}O{sub 3}) prepared by ion implantation have been studied as a model to investigate the potential of such materials for applications in high technology areas. The implantation was performed with 160 keV ions at several doses; the nanocomposites were then annealed at selected temperatures between 700 and 1,400 C in an Ar-4%H{sub 2} atmosphere for 1 hour. Rutherford backscattering spectroscopy and high resolution transmission electron microscopy (TEM) were used to characterize the structure of these nanocomposites. Measurements showed that damage depth extended to about 300 nm and the embedded iron extended to about 200 nm. This region became amorphous when the fluence reaches 2 {times} 10{sup 17} Fe/cm{sup 2} at this energy. Thermal annealing could be used to restore the crystallinity to the damaged near-surface region, to form the metallic colloids, and also to coarsen the precipitates. In the case of high dose implantation, oriented precipitates with diameters of 2 to 3 nm were identified by TEM techniques as {alpha}-Fe which had the following orientation relationship with the sapphire matrix: <111>{sub Fe} {parallel} <310>{sub Sapphire} and {l_brace}01{bar 1}{r_brace}{sub Fe} {parallel} {l_brace}006{r_brace}{sub Sapphire}. The optical density and luminescence spectra were also measured. The predominant defects were oxygen vacancies with two electrons (F center) at the known absorption peak of 200 nm.

Ren, S.X.; McHargue, C.J. [Univ. of Tennessee, Knoxville, TN (United States). Dept. of Materials Science and Engineering; Allard, L.F.; Chen, Y.; Hunn, J.D.; Lucas, B.N.; Williams, R.K. [Oak Ridge National Lab., TN (United States)

1994-12-31

348

[Current status of implantable cardioverter defibrillator].  

PubMed

Clinical trials have established the superiority of the implantable cardioverter defibrillator (ICD) over antiarrhythmic drug therapy in survivors of sudden cardiac arrest and in high risk patients with coronary artery disease. The ICD has evolved to overcome the limitation of earlier devices that required thoracotomy for implantation and inadequate therapies. At present, it is implanted in a similar manner to cardiac pacemakers and incorporates discrimination algorithms to prevent inappropriate therapy. Managing the patients with an ICD requires an understanding of the multiprogrammable features of modern devices. The cost-effectiveness of ICD therapy appears favorable, given the marked survival benefit seen in randomized trials relative to antiarrhythmic drug treatment. A goal of newer-generation ICD devices is to avoid intervention. Such programmable therapies may include pacing to avoid long short coupling, intermittent antiarrhythmic drug infusion, or multisite pacing to improve hemodynamics. Further advances in device technology will undoubtedly expand the role of the ICD in the primary and secondary prevention of sudden cardiac arrest. PMID:12001878

Iturralde Torres, Pedro

2002-01-01

349

Single Color Centers Implanted in Diamond Nanostructures  

E-print Network

The development of materials processing techniques for optical diamond nanostructures containing a single color center is an important problem in quantum science and technology. In this work, we present the combination of ion implantation and top-down diamond nanofabrication in two scenarios: diamond nanopillars and diamond nanowires. The first device consists of a 'shallow' implant (~20nm) to generate Nitrogen-vacancy (NV) color centers near the top surface of the diamond crystal. Individual NV centers are then isolated mechanically by dry etching a regular array of nanopillars in the diamond surface. Photon anti-bunching measurements indicate that a high yield (>10%) of the devices contain a single NV center. The second device demonstrates 'deep' (~1\\mu m) implantation of individual NV centers into pre-fabricated diamond nanowire. The high single photon flux of the nanowire geometry, combined with the low background fluorescence of the ultrapure diamond, allows us to sustain strong photon anti-bunching even at high pump powers.

Birgit J. M. Hausmann; Thomas M. Babinec; Jennifer T. Choy; Jonathan S. Hodges; Sungkun Hong; Irfan Bulu; A. Yacoby; M. D. Lukin; Marko Lon?ar

2010-09-21

350

Chapter 29. The Retinal Implant Project The Retinal Implant Project  

E-print Network

of the animal, demonstrating the operation of the device. We completed our first generation in vivo experiments, a patient would wear a camera mounted on a pair of glasses, which transmits image data to an implant. At the completion of the surgery, the whole implant was covered by the conjunctiva. No complications were observed

351

Microtechnologies in implant and restorative dentistry: a stroll through a digital dental landscape.  

PubMed

This is an explanatory article introducing the combination of various technologies used in implant and restorative dentistry. The aim of the article is to provide an overview of some of the techniques supporting the restorative treatment plan at various stages to provide contemporary, state-of-the-art bridgework based on dental implants. It is a discussion of the way existing technologies used in fields of engineering and medicine are brought together to form a complete process. PMID:20608495

Dawood, A; Purkayastha, S; Patel, S; MacKillop, F; Tanner, S

2010-01-01

352

Additive manufacturing: From implants to organs.  

PubMed

Additive manufacturing (AM) constructs 3D objects layer by layer under computer control from 3D models. 3D printing is one example of this kind of technology. AM offers geometric flexibility in its products and therefore allows customisation to suit individual needs. Clinical success has been shown with models for surgical planning, implants, assistive devices and scaffold-based tissue engineering. The use of AM to print tissues and organs that mimic nature in structure and function remains an elusive goal, but has the potential to transform personalised medicine, drug development and scientific understanding of the mechanisms of disease.  PMID:25214247

Douglas, Tania S

2014-06-01

353

Model-Based Investigation on the Behavior of ECT Signals According to the Changes in Geometry and Material Property of a Steam Generator Tube  

NASA Astrophysics Data System (ADS)

The interpretation of eddy current testing (ECT) signals is known as a truly difficult task since it is influenced by various factors including the variation in geometry and material properties of steam generator tubes. To provide necessary information for the proper signal interpretation, the present study investigates the behavior of bobbin-coil ECT signal according to the changes in diameter, electric conductivity and magnetic permeability of a tube using a 2-dimensional finite element analysis program. It was found that the behaviors of a differential bobbin coil probe were similar to those of an absolute bobbin coil probe for localized variation. However, quite different behaviors were observed for two probes for the cases of smooth variation in geometry. It was also found that the phase angle of ECT signals could be used as an effective feature to identify the kind of abnormalities.

Kim, Young H.; Song, Sung-Jin; Heo, Jin-Soo; Han, Jung-Ho; Choi, Young-Hwan

2004-02-01

354

Bone cement implantation syndrome.  

PubMed

Bone cement implantation syndrome (BCIS) is characterized by hypoxia, hypotension, cardiac arrhythmias, increased pulmonary vascular resistance and cardiac arrest. It is a known cause of morbidity and mortality in patients undergoing cemented orthopaedic surgeries. The rarity of the condition as well as absence of a proper definition has contributed to under-reporting of cases. We report a 59-year-old woman who sustained fracture of the neck of her left femur and underwent an elective hybrid total hip replacement surgery. She collapsed during surgery and was revived only to succumb to death twelve hours later. Post mortem findings showed multiorgan disseminated microembolization of bone marrow and amorphous cement material. PMID:23817399

Razuin, R; Effat, O; Shahidan, M N; Shama, D V; Miswan, M F M

2013-06-01

355

Implantable medical sensor system  

DOEpatents

An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.

Darrow, Christopher B. (Pleasanton, CA); Satcher, Jr., Joe H. (Modesto, CA); Lane, Stephen M. (Oakland, CA); Lee, Abraham P. (Walnut Creek, CA); Wang, Amy W. (Berkeley, CA)

2001-01-01

356

Broad beam ion implanter  

DOEpatents

An ion implantation device for creating a large diameter, homogeneous, ion beam is described, as well as a method for creating same, wherein the device is characterized by extraction of a diverging ion beam and its conversion by ion beam optics to an essentially parallel ion beam. The device comprises a plasma or ion source, an anode and exit aperture, an extraction electrode, a divergence-limiting electrode and an acceleration electrode, as well as the means for connecting a voltage supply to the electrodes.

Leung, Ka-Ngo (Hercules, CA)

1996-01-01

357

Broad beam ion implanter  

DOEpatents

An ion implantation device for creating a large diameter, homogeneous, ion beam is described, as well as a method for creating same, wherein the device is characterized by extraction of a diverging ion beam and its conversion by ion beam optics to an essentially parallel ion beam. The device comprises a plasma or ion source, an anode and exit aperture, an extraction electrode, a divergence-limiting electrode and an acceleration electrode, as well as the means for connecting a voltage supply to the electrodes. 6 figs.

Leung, K.N.

1996-10-08

358

Production of Endohedral Fullerenes by Ion Implantation  

SciTech Connect

The empty interior cavity of fullerenes has long been touted for containment of radionuclides during in vivo transport, during radioimmunotherapy (RIT) and radioimaging for example. As the chemistry required to open a hole in fullerene is complex and exceedingly unlikely to occur in vivo, and conformational stability of the fullerene cage is absolute, atoms trapped within fullerenes can only be released during extremely energetic events. Encapsulating radionuclides in fullerenes could therefore potentially eliminate undesired toxicity resulting from leakage and catabolism of radionuclides administered with other techniques. At the start of this project however, methods for production of transition metal and p-electron metal endohedral fullerenes were completely unknown, and only one method for production of endohedral radiofullerenes was known. They therefore investigated three different methods for the production of therapeutically useful endohedral metallofullerenes: (1) implantation of ions using the high intensity ion beam at the Oak Ridge National Laboratory (ORNL) Surface Modification and Characterization Research Center (SMAC) and fullerenes as the target; (2) implantation of ions using the recoil energy following alpha decay; and (3) implantation of ions using the recoil energy following neutron capture, using ORNL's High Flux Isotope Reactor (HFIR) as a thermal neutron source. While they were unable to obtain evidence of successful implantation using the ion beam at SMAC, recoil following alpha decay and neutron capture were both found to be economically viable methods for the production of therapeutically useful radiofullerenes. In this report, the procedures for preparing fullerenes containing the isotopes {sup 212}Pb, {sup 212}Bi, {sup 213}Bi, and {sup 177}Lu are described. None of these endohedral fullerenes had ever previously been prepared, and all of these radioisotopes are actively under investigation for RIT. Additionally, the chemistry for derivatizing the radiofullerenes for water-solubility and a method for removing exohedral radionuclides are reported. The methods and chemistry developed during this CRADA are the crucial first steps for the development of fullerenes as a method superior to existing technologies for in vivo transport of radionuclides.

Diener, M.D.; Alford, J. M.; Mirzadeh, S.

2007-05-31

359

The optimal design of an implant to improve bone quality of implant surroundings based on stress analysis  

NASA Astrophysics Data System (ADS)

Research on how implant surface shape contributes to long-term stability after implantation is important in the field of orthopaedics. In particular, technology that controls various bone quality parameters and voluntary bone inducement in implant surroundings should be developed for the next generation of implants and this will improve the patient's quality of life (QOL). For this research, we focused on the inducement of the appropriate alignment for biological apatite (BAp) crystallites and related collagen (Col.) fibres as a bone quality parameter. In this study, we predicted that when stress is applied to bone, the BAp/Col. preferential alignment can be formed if osteocytes are in an environment that is aligned with the principle stress vector. We tested this idea by introducing grooves in the principal stress direction on the surface of an implant. This work thus analyzes the effect of stress transmission by a load at the proximal femur on the bone inside and near the grooves by using mechanical simulation in which groove angles can be changed on the implant surface. Coordinate data from the mechanical simulation of the combined bone/implant environment was verified against the coordinate data obtained by CT scans of actual canine bone. Results suggest that the tendency of stress transmission differs depending on the position and angle of the grooves and based on a vector diagram of the maximum and minimum principal stresses. The simulation was able to predict bone dynamics in vivo and enabled a best design of an implant to control the BAp/Col. alignment as an index of bone quality.

Noyama, Yoshihiro; Nagayama, Noriyuki; Kuramoto, Koichi; Nakano, Takayoshi

2009-05-01

360

Porous metal for orthopedics implants  

PubMed Central

Summary Porous metal has been introduced to obtain biological fixation and improve longevity of orthopedic implants. The new generation of porous metal has intriguing characteristics that allows bone healing and high osteointegration of the metallic implants. This article gives an overview about biomaterials properties of the contemporary class of highly porous metals and about the clinical use in orthopaedic surgery. PMID:24133527

Matassi, Fabrizio; Botti, Alessandra; Sirleo, Luigi; Carulli, Christian; Innocenti, Massimo

2013-01-01

361

Normal Ear, Ear with Hearing Loss, and Cochlear Implant Procedure  

MedlinePLUS

... Medical Devices Products and Medical Procedures Implants and Prosthetics Cochlear Implants Section Contents Menu Products and Medical Procedures Implants and Prosthetics Cochlear Implants What is a Cochlear Implant? Benefits ...

362

Modern metal processing for improved load-bearing surgical implants.  

PubMed

A review of modern methods for preparing metallic alloys that could be useful for the fabrication of load-bearing metallic biomaterials is presented. The use of rapid solidification processing and surface modification of metals by ion implantation or surface coatings and variations thereof is used currently for the formation of novel metallic alloys in other high-tech fields, notably the optoelectronics industry. Further studies to explore potential benefits for surgical implant fabrication through the application of these technologies is recommended. PMID:1878463

Pilliar, R M

1991-03-01

363

Alkaline aqueous electrolyte cells for biomedical implantable applications  

SciTech Connect

Technological advances, latest state of the art and ultimate achieved performance of primary mercuric oxide-zinc cells for biomedical, implantable applications are reviewed. The data presented serve as a basis against which long-term performance data of lithium batteries could be compared in the future. The different cell-internal and cell-external self-discharge processes are analyzed as to their relative importance in causing capacity loss. Other aqueous electrolyte, alkaline primary cells, such as the HgO-Cd cell, and secondary NiOOH-Cd batteries are also discussed regarding biomedical implantable applications. 56 refs.

Ruetschi, P.

1980-01-01

364

Tribological properties of nitrogen implanted and boron implanted steels  

SciTech Connect

Samples of a steel with high chrome content was implanted separately with 75 keV nitrogen ions and with 75 keV boron ions. Implanted doses of each ion species were 2-, 4-, and 8 {times} 10{sup 17}/cm{sup 2}. Retained doses were measured using resonant non-Rutherford Backscattering Spectrometry. Tribological properties were determined using a pin-on-disk test with a 6-mm diameter ruby pin with a velocity of 0.94 m/min. Testing was done at 10% humidity with a load of 377 g. Wear rate and coefficient of friction were determined from these tests. While reduction in the wear rate for nitrogen implanted materials was observed, greater reduction (more than an order of magnitude) was observed for boron implanted materials. In addition, reduction in the coefficient of friction for high-dose boron implanted materials was observed. Nano-indentation revealed a hardened layer near the surface of the material. Results from grazing incidence x-ray diffraction suggest the formation of Fe{sub 2}N and Fe{sub 3}N in the nitrogen implanted materials and Fe{sub 3}B in the boron implanted materials. Results from transmission electron microscopy will be presented.

Kern, K.T. [Norfolk State Univ., VA (United States). Center for Materials Research; Walter, K.C.; Griffin, A.J. Jr.; Kung, H.; Lu, Y.; Nastasi, M.; Tesmer, J.R. [Los Alamos National Lab., NM (United States). Materials Science and Technology Div.; Fayeulle, S. [Ecole Centrale De Lyon, Ecully (France)

1996-06-01

365

The Nuclear Energy Advanced Modeling and Simulation Enabling Computational Technologies FY09 Report  

SciTech Connect

In this document we report on the status of the Nuclear Energy Advanced Modeling and Simulation (NEAMS) Enabling Computational Technologies (ECT) effort. In particular, we provide the context for ECT In the broader NEAMS program and describe the three pillars of the ECT effort, namely, (1) tools and libraries, (2) software quality assurance, and (3) computational facility (computers, storage, etc) needs. We report on our FY09 deliverables to determine the needs of the integrated performance and safety codes (IPSCs) in these three areas and lay out the general plan for software quality assurance to meet the requirements of DOE and the DOE Advanced Fuel Cycle Initiative (AFCI). We conclude with a brief description of our interactions with the Idaho National Laboratory computer center to determine what is needed to expand their role as a NEAMS user facility.

Diachin, L F; Garaizar, F X; Henson, V E; Pope, G

2009-10-12

366

A Retrospective Analysis of Ruptured Breast Implants  

PubMed Central

Background Rupture is an important complication of breast implants. Before cohesive gel silicone implants, rupture rates of both saline and silicone breast implants were over 10%. Through an analysis of ruptured implants, we can determine the various factors related to ruptured implants. Methods We performed a retrospective review of 72 implants that were removed for implant rupture between 2005 and 2014 at a single institution. The following data were collected: type of implants (saline or silicone), duration of implantation, type of implant shell, degree of capsular contracture, associated symptoms, cause of rupture, diagnostic tools, and management. Results Forty-five Saline implants and 27 silicone implants were used. Rupture was diagnosed at a mean of 5.6 and 12 years after insertion of saline and silicone implants, respectively. There was no association between shell type and risk of rupture. Spontaneous was the most common reason for the rupture. Rupture management was implant change (39 case), microfat graft (2 case), removal only (14 case), and follow-up loss (17 case). Conclusions Saline implants have a shorter average duration of rupture, but diagnosis is easier and safer, leading to fewer complications. Previous-generation silicone implants required frequent follow-up observation, and it is recommended that they be changed to a cohesive gel implant before hidden rupture occurs. PMID:25396188

Baek, Woo Yeol; Lew, Dae Hyun

2014-01-01

367

Microbiome of peri-implant infections: Lessons from conventional, molecular and metagenomic analyses.  

PubMed

Osseointegrated dental implants are now a well-established treatment option in the armament of restorative dentistry. These technologically advanced devices are designed to functionally and esthetically replace missing teeth. Despite the revolutionary advances that implants have incurred, they have also provided the oral cavity with new artificial surfaces prone to the formation of oral biofilms, similarly to the hard tissue surfaces of natural teeth. Biofilm formation on the implant surface can trigger the inflammatory destruction of the peri-implant tissue, in what is known as peri-implantitis. The mixed microbial flora of peri-implant infections resembles that of periodontal infections, with some notable differences. These are likely to expand with the ever increasing application of metagenomics and metatrascriptomics in the analysis of oral ecology. This review presents the wealth of knowledge we have gained from microbiological methods used in the characterization of peri-implant microflora and sheds light over potential new benefits, as well as limitations, of the new sequencing technology in our understanding of peri-implant disease pathogenesis. PMID:25654499

Charalampakis, Georgios; Belibasakis, Georgios N

2015-04-01

368

Or Th Pr Au Cr Two-Year Master Program (120 ECTS)  

E-print Network

focus in sustainable car technologies Compulsory courses Module 1 : Vehicle dynamics and safety MECA0492-2 Vehicle dynamics (english language) - Pierre DUYSINX Q1 30 20 - 4 MECA0493-2 Vehicle aerodynamics (english

Wolper, Pierre

369

Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants.  

PubMed

Over the past decade, various implantable devices have been developed to treat diseases that were previously difficult to manage such diabetes, chronic pain, and neurodegenerative disorders. However, translation of these novel technologies into clinical practice is often difficult because fibrotic encapsulation and/or rejection impairs device function after body implantation. Ideally, cells of the host tissue should perceive the surface of the implant being similar to the normal extracellular matrix. Here, we developed an innovative approach to provide implant surfaces with adhesive protein micropatterns. The patterns were designed to promote adhesion of fibroblasts and macrophages by simultaneously suppressing fibrogenic activation of both cell types. In a rat model, subcutaneously implanted silicone pads provided with the novel micropatterns caused 6-fold lower formation of inflammatory giant cells compared with clinical grade, uncoated, or collagen-coated silicone implants. We further show that micropatterning of implants resulted in 2-3-fold reduced numbers of pro-fibrotic myofibroblast by inhibiting their mechanical activation. Our novel approach allows controlled cell attachment to implant surfaces, representing a critical advance for enhanced biointegration of implantable medical devices. PMID:25907047

Majd, Hicham; Scherer, Saja S; Boo, Stellar; Ramondetti, Silvio; Cambridge, Elizabeth; Raffoul, Wassim; Friedrich, Michael; Pittet, Brigitte; Pioletti, Dominique; Hinz, Boris; Pietramaggiori, Giorgio

2015-06-01

370

Ion implantation for high performance III-V JFETS and HFETS  

SciTech Connect

Ion implantation has been an enabling technology for realizing many high performance electronic devices in III-V semiconductor materials. We report on advances in ion implantation processing for GaAs JFETs (joint field effect transistors), AlGaAs/GaAs HFETs (heterostructure field effect transistors), and InGaP or InAlP-barrier HFETs. The GaAs JFET has required the development of shallow p-type implants using Zn or Cd with junction depths down to 35 nm after the activation anneal. Implant activation and ionization issues for AlGaAs are reported along with those for InGaP and InAlP. A comprehensive treatment of Si-implant doping of AlGaAs is given based on donor ionization energies and conduction band density-of-states dependence on Al-composition. Si and Si+P implants in InGaP are shown to achieve higher electron concentrations than for similar implants in AlGaAs due to absence of the deep donor level. An optimized P co- implantation scheme in InGaP is shown to increase the implanted donor saturation level by 65%.

Zolper, J.C.; Baca, A.G.; Sherwin, M.E.; Klem, J.F.

1996-06-01

371

The effect of plasma chemical oxidation of titanium alloy on bone-implant contact in rats.  

PubMed

Many different technologies have been used to enhance osseointegration in orthopaedic and dental implant surgery. Hydroxyapatite coatings, pure or in combination with growth factors or bisphosphonates, showed improved osseointegration of titanium alloy implants. We choose a different approach to enhance osseointegration: plasma chemical oxidation was used to modify the surface of titanium alloy implants. This technique converts the nm-thin natural occurring titanium oxide layer on an implant to a 4 ?m thick ceramic coating (TiOB surface). Bioactive TiOB surfaces have a macroporous structure and were loaded with calcium and phosphorus, while bioinert TiOB surfaces are smooth. A rat tibial model with bilateral placement of titanium alloy implants was employed to analyze the bone response to TiOB surfaces in vivo. 64 rats were randomly assigned to four groups of implants: (1) titanium alloy (control), (2) titanium alloy, type III anodization, (3) bioinert TiOB surface and (4) bioactive TiOB surface. Mechanical fixation, peri-implant-bone area and bone contact were evaluated by pull-out tests and histology at three and eight weeks. Shear strength and bone contact at eight weeks were significantly increased in the bioactive TiOB group compared to all other groups. The results of plasma chemical oxidation in a rat model showed that the bioactive TiOB surface has a positive effect on implant anchorage by enhancing the bone-implant contact in normal bone. PMID:21840591

Diefenbeck, Michael; Mückley, Thomas; Schrader, Christian; Schmidt, Jürgen; Zankovych, Sergiy; Bossert, Jörg; Jandt, Klaus D; Faucon, Mathilde; Finger, Ulrich

2011-11-01

372

Implant-supported full-mouth reconstruction Malo Implant Bridge.  

PubMed

This article describes the clinical techniques and laboratory procedures for fabricating a predictable Malo Implant Bridge involving application of an occlusal screw-retained implant superstructure on the basis of the All-on-4 concept. The Malo Implant Bridge features a removable occlusal screw-retained superstructure; fabrication of the framework with a computer-aided design/computer-aided manufacturing system allowing accurate adaptation; and use of the final tooth position model with guide temporary crowns allowing easy porcelain build-up and satisfying the patient's esthetic concerns. PMID:22856035

Kodama, Taishi

2012-06-01

373

The Aula EspaZio Gela and the Master of Space Science and Technology in the Universidad Del País Vasco (University of the Basque Country)  

ERIC Educational Resources Information Center

We present the Aula EspaZio Gela, a facility dedicated to teaching Space Science and Technology at the master and doctorate level at the University of the Basque Country (Spain), and to promoting the development of this field in both public and private sectors. The one-year master's degree in Space Science and Technology (60 ECTS (European…

Sánchez-Lavega, Agustín; Pérez-Hoyos, Santiago; Hueso, Ricardo; del Río-Gaztelurrutia, Teresa; Oleaga, Alberto

2014-01-01

374

Early bone formation adjacent to oxidized and machined implant surfaces: a histologic study.  

PubMed

Various designs of dental implants representing different geometries and surface technologies are commercially available for patient treatment. However, data with regard to the biologic events that occur immediately after implant placement, regardless of the surface characteristic, are scarce. It has become a common procedure to perform immediate/early prosthetic loading rather than delayed loading. The goal of this study was to observe the early biologic events of peri-implant healing to understand the role of surface modifications in relation to the early phases of bone integration. The secondary goal was to observe the possible differences in the healing pattern at two oral implant surfaces differing in morphology and roughness (Ra, with Ra values ranging from 0.5 ?m (machined surface; MS) to 1.5 ?m (oxidized surface; OS). A total of 36 implants were placed in six foxhound dogs, equally divided between machined and oxidized surfaces. Three implants were positioned per hemimandible following a randomization scheme. Each animal was euthanized at a specific time point for histologic observation and histomorphometry: immediately after implant insertion and after 24 hours, 7 days, 15 days, 30 days, and 90 days. The study demonstrated an extremely low bone-implant contact (BIC) for both OS and MS implant surfaces during the first 15 days after implant placement (ranging from 12.9% to 26.9% independent of the implant surface). Increased BIC values were observed only in the 30- and 90-day specimens. The presence and the degradation of residual bone particles acted as centers for new bone formation, with osteoblasts lining osteoid tissue and subsequently woven bone independent of the implant surface characteristics. The bone-forming activity appeared strongly reduced after 30 days of healing and seemed to be complete only in the 90-day specimens, where abundant lamellar bone was evident. There is a continuing effort to develop improved titanium surfaces to achieve more rapid osseointegration and improve BIC, with the ultimate goal of applying occlusal load as early as possible. Since immediate or early implant loading is applied during and not after the first 15 days, the findings in the present study of an extremely low BIC and limited mineralized bone formation for both implant surfaces during the first 15 days after implant placement suggest that the surface roughness may not be a key factor for successful osseointegration of immediately or early loaded implants. Within the limits of this study, it can be stated that osseointegration follows a similar healing pattern with machined and oxidized implant surfaces. PMID:25734702

Simion, Massimo; Benigni, Marco; Al-Hezaimi, Khalid; Kim, David M

2015-01-01

375

Evaluation of synthetic osteochondral implants.  

PubMed

This translational animal model study was designed to assess function, bone ingrowth and integration, and joint pathology associated with two different synthetic, bilayered osteochondral implants over a 3-month period after implantation into the femoral condyles of dogs. SynACart-Titanium (n?=?6) and SynACart-PEEK (n?=?6) (Arthrex, Naples, FL, and Sites Medical, Columbia City, IN) implants were press-fit into the lateral or medial femoral condyle (alternating location) of purpose-bred adult research dogs. Dogs were humanely euthanized 3 months after surgery and the operated knees were assessed radiographically, arthroscopically, grossly, and histologically. Based on all assessments, both types of implants were well tolerated and safe with no evidence for infection, migration, or rejection. Half of the SynACart-PEEK implants showed radiographic and histologic evidence of poor incorporation with all of these being in the lateral femoral condyle. SynACart-Titanium implants were considered effective in terms of integration into bone, lack of damage to surrounding and apposing articular cartilage, and maintenance of implant integrity and architecture for the duration of the study. PMID:24281985

Cook, James L; Kuroki, Keiichi; Bozynski, Chantelle C; Stoker, Aaron M; Pfeiffer, Ferris M; Cook, Cristi R

2014-08-01

376

Ultraviolet photofunctionalization of titanium implants.  

PubMed

In the face of growing demands and challenges in implant therapy, implant surfaces with improved biologic capabilities are required. This review paper summarizes the findings of recent in vitro and in vivo studies related to ultraviolet (UV) photofunctionalization of titanium. UV photofunctionalization is defined as an overall phenomenon of modification of titanium surfaces occuring after UV treatment, including the alteration of physicochemical properties and the enhancement of biologic capabilities. Bone morphogenesis around UV-treated titanium implants is distinctly improved compared with that seen around untreated control implants, leading to rapid and complete establishment of osseointegration with nearly 100% bone-to-implant contact in an animal model, as opposed to less than 55% for untreated implants. A series of in vitro studies demonstrated considerable enhancement of attachment, retention, and subsequent functional cascades of osteogenic cells derived from animals and humans after UV treatment. UV treatment converts titanium surfaces from hydrophobic to superhydrophilic and removes unavoidably contaminated hydrocarbons. UV-treated titanium surfaces also manifest a unique electrostatic status and act as direct cell attractants without the aid of ionic and organic bridges, which imparts a novel physicochemical functionality to titanium, which has long been understood as a bioinert material. UV treatment is simple and low in cost, and it has been proven effective for all types of titanium surfaces tested. These data suggest that UV photofunctionalization can be a novel, effective measure to improve implant therapy in the dental and orthopedic fields. Future research will focus on validating these findings in clinical studies. PMID:24451893

Ogawa, Takahiro

2014-01-01

377

Percutaneous Pulmonary Valve Implantation  

PubMed Central

Pulmonary regurgitation (PR) is a frequent sequelae after repair of tetralogy of Fallot, pulmonary atresia, truncus arteriosus, Rastelli and Ross operation. Due to patient growth and conduit degeneration, these conduits have to be changed frequently due to regurgitation or stenosis. However, morbidity is significant in these repeated operations. To prolong conduit longevity, bare-metal stenting in the right ventricular outflow tract (RVOT) obstruction has been performed. Stenting the RVOT can reduce the right ventricular pressure and symptomatic improvement, but it causes PR with detrimental effects on the right ventricle function and risks of arrhythmia. Percutaneous pulmonary valve implantation has been shown to be a safe and effective treatment for patients with pulmonary valve insufficiency, or stenotic RVOTs. PMID:23170091

Lee, Hyoung-Doo

2012-01-01

378

Implantable Electrical Vesical Stimulator  

PubMed Central

Considerable interest has been shown recently in electrical stimulation of the incompetent urinary bladder. Two types of bladder stimulation have been attempted in dogs and in humans: (a) stimulation of nervi erigentes and (b) direct stimulation of the detrusor urinae muscle. After several years of animal experimentation, a vesical stimulator, built on a new electronic principle, was implanted successfully in a paraplegic patient who has a complete post-traumatic lower motor neuron lesion. The stimulator has been working satisfactorily since November 1965. This stimulator could eventually also be used in purely sensory sacral lesions, in well-selected incomplete lower motor neuron lesions, and in flaccid detrusors of the myogenic type. A review of the literature up to the time of this report shows only a few encouraging but incomplete results in humans. The techniques and the complexities involved in this problem are discussed. ImagesFig. 1Fig. 3Fig. 5 PMID:5923472

Susset, J. G.; Boctor, Z. N.; Rosario, F.; Rabinovitch, H.; Nagler, B.; MacKinnon, K. J.

1966-01-01

379

Soft Cochlear Implantation: Rationale for the Surgical Approach  

PubMed Central

Recent advances in cochlear implant technology have focused renewed attention on the preservation of residual hearing. The focus on preservation of residual hearing is driven by the concept of electroacoustic stimulation. This option depends on the insertion of a short cochlear implant electrode into the basal region of the cochlea while preserving native function in the apical region. The desire to preserve residual hearing has led to the development of the soft-surgery cochlear implantation technique. Here, the authors evaluate its various components. Avoiding entry of blood into the cochlea and the use of hyaluronate seem to be reasonably supported, whereas the use of topical steroids is unlikely to be beneficial. The site of entry into the cochlea, the use of contoured or straight devices, and the depth of insertion are also evaluated. The authors highlight the importance of systematic recording of outcomes and surgical events. PMID:19447766

Friedland, David R.; Runge-Samuelson, Christina

2009-01-01

380

Simplifying the 45nm SDE Process with ClusterBoron® and ClusterCarbon™ Implantation  

NASA Astrophysics Data System (ADS)

The processes used to form an advanced PMOS SDE become increasing complex with each technology generation. Aggressive requirements for junction depth, sheet resistance and abruptness are difficult to satisfy with conventional technologies. The fundamental issues are the low productivity of implant systems at the required low boron implant energies and the diffusion rate of boron in silicon at the temperatures needed for activation. We propose an alternate process sequence with the goal of simplifying the process module by eliminating the Ge PAI implant and using a conventional spike anneal. Our approach is to utilize a ClusterCarbon implant to control boron diffusion, a ClusterBoron® implant for high productivity at low process energy and a conventional spike anneal at moderate temperature. The ClusterCarbon™ implant uses the same ClusterIon® source and related system as the ClusterBoron implant. This process combination provides a solution to the technology requirements using conventional production tools, high productivity and a simple, direct path to optimizing the SDE conditions.

Krull, Wade; Haslam, Brian; Horsky, Tom; Verheyden, Kurt; Funk, Klaus

2006-11-01

381

Introduction to cochlear implants Philipos C. Loizou  

E-print Network

1 Introduction to cochlear implants Philipos C. Loizou For centuries, people believed that only speech. Today, a prosthetic device, called cochlear implant, can be implanted in the inner ear and can to the development of a successful cochlear implant. After all, it is important to know how a normal auditory system

Allen, Jont

382

Cochlear implants for the profoundly deaf  

Microsoft Academic Search

A fairly recent development in treatment for the profoundly deaf is the cochlear implant. A cochlear implant is an electronic device that partially restores hearing via electrical stimulation of the inner ear. The only cochlear implant currently approved by the Federal Drug Administration for use in both children and adults is the Nucleus 2 Multiple Channel Cochlear Implant manufactured by

T. A. Zwolan; P. R. Kileny

1993-01-01

383

Speech and language development following cochlear implantation  

Microsoft Academic Search

Cochlear implants apparently restore the inner ear functions and increase the acoustic consciousness of pre- and postlingually deaf children. However, not all deaf individuals benefit equally from the implantation of this electronic device and several variables appear to critically affect post-implant linguistic performance. We review the scientific literature on particular aspects of speech and language development following cochlear implantation. The

Christine Ouellet; Henri Cohen

1999-01-01

384

Otologics active middle ear implants.  

PubMed

This article describes outcomes for the Otologics active middle ear implant for the semi-implantable and fully implantable (Carina, Otologics LLC, Boulder, CO) devices. Inclusion and exclusion criteria are reported in detail for surgical and audiologic management. Results from the clinical trial demonstrated no change for unaided air and bone conduction thresholds and no significant change in monosyllabic word scores or sentences in noise. Experiments are reported for conductive and mixed types of hearing losses in animal and human cadaveric models. These devices are in their infancy, and further study is needed to better identify candidates and develop appropriate expectations. PMID:25301507

Jenkins, Herman A; Uhler, Kristin

2014-12-01

385

Pediatric cochlear implantation: an update.  

PubMed

Deafness in pediatric age can adversely impact language acquisition as well as educational and social-emotional development. Once diagnosed, hearing loss should be rehabilitated early; the goal is to provide the child with maximum access to the acoustic features of speech within a listening range that is safe and comfortable. In presence of severe to profound deafness, benefit from auditory amplification cannot be enough to allow a proper language development. Cochlear implants are partially implantable electronic devices designed to provide profoundly deafened patients with hearing sensitivity within the speech range. Since their introduction more than 30 years ago, cochlear implants have improved their performance to the extent that are now considered to be standard of care in the treatment of children with severe to profound deafness. Over the years patient candidacy has been expanded and the criteria for implantation continue to evolve within the paediatric population. The minimum age for implantation has progressively reduced; it has been recognized that implantation at a very early age (12-18 months) provides children with the best outcomes, taking advantage of sensitive periods of auditory development. Bilateral implantation offers a better sound localization, as well as a superior ability to understand speech in noisy environments than unilateral cochlear implant. Deafened children with special clinical situations, including inner ear malformation, cochlear nerve deficiency, cochlear ossification, and additional disabilities can be successfully treated, even thogh they require an individualized candidacy evaluation and a complex post-implantation rehabilitation. Benefits from cochlear implantation include not only better abilities to hear and to develop speech and language skills, but also improved academic attainment, improved quality of life, and better employment status. Cochlear implants permit deaf people to hear, but they have a long way to go before their performance being comparable to that of the intact human ear; researchers are looking for more sophisticated speech processing strategies as well as a more efficient coupling between the electrodes and the cochlear nerve with the goal of dramatically improving the quality of sound of the next generation of implants. PMID:25179127

Vincenti, Vincenzo; Bacciu, Andrea; Guida, Maurizio; Marra, Francesca; Bertoldi, Barbara; Bacciu, Salvatore; Pasanisi, Enrico

2014-01-01

386

Hardness of ion implanted ceramics  

SciTech Connect

It has been established that the wear behavior of ceramic materials can be modified through ion implantation. Studies have been done to characterize the effect of implantation on the structure and composition of ceramic surfaces. To understand how these changes affect the wear properties of the ceramic, other mechanical properties must be measured. To accomplish this, a commercially available ultra low load hardness tester has been used to characterize Al/sub 2/O/sub 3/ with different implanted species and doses. The hardness of the base material is compared with the highly damaged crystalline state as well as the amorphous material.

Oliver, W.C.; McHargue, C.J.; Farlow, G.C.; White, C.W.

1985-01-01

387

Fracture behaviour of implant–implant- and implant–tooth-supported all-ceramic fixed dental prostheses utilising zirconium dioxide implant abutments  

Microsoft Academic Search

This in vitro study investigated the fracture behaviour of implant–implant-supported and implant–tooth-supported all-ceramic\\u000a fixed dental prostheses (FDP) using zirconium dioxide implant abutments (FRIADENT® CERCON® abutments, DENTSPLY Friadent).\\u000a Six different test groups (n?=?8) were prepared. Groups 1, 2, 4, and 5 represented an implant–implant-supported FDP condition, whereas groups 3 and 6\\u000a simulated an implant–tooth-supported FDP condition. The second right premolar of

Frank Philipp Nothdurft; Sabine Merker; Peter Reinhard Pospiech

2011-01-01

388

Engineering BSc -180 ECTS programs -emphasis on preparation for further studies at MSc/PhD level Financial Engineering Engineering Management Biomedical Engineering Mechatronics Engineering Mechanical Engineering  

E-print Network

Financial Engineering Engineering Management Biomedical Engineering Mechatronics Engineering Mechanical-HEIL Physics III T-411-MECH Mechatronics I T-536-RENN Fluid Dynamics **Engineering course **EngineeringEngineering BSc - 180 ECTS programs - emphasis on preparation for further studies at MSc/PhD level

Karlsson, Brynjar

389

ReProTool Version 2.0: Re-Engineering Academic Curriculum Using Learning Outcomes, ECTS and Bologna Process Concepts  

ERIC Educational Resources Information Center

Purpose: The purpose of this paper is to present ReProTool Version 2.0, a software tool that is used for the European Credit Transfer System (ECTS) and the Bologna Process re-engineering of academic programmes. The tool is the result of an 18 months project (February 2012-July 2013) project, co-financed by the European Regional Development Fund…

Pouyioutas, Philippos; Gjermundrod, Harald; Dionysiou, Ioanna

2012-01-01

390

Combining Peer-Assessment with Negotiated Learning Activities on a Day-Release Undergraduate-Level Certificate Course (ECTS Level 3)  

ERIC Educational Resources Information Center

Peer-assessment was used within a negotiated curriculum in a module on training and development at ECTS level 3. The students on the programme were exclusively day-release and all had a major responsibility for the management and delivery of work-based training programmes. Analysis of student evaluations, supplemented by those of university…

McMahon, Tim

2010-01-01

391

The Radiation Belt Storm Probes (RBSP) Energetic Particle, Composition, and Thermal plasma (ECT) Suite: Upcoming Opportunties for Testing Radiation Belt Acceleration Mechanisms  

NASA Astrophysics Data System (ADS)

The Radiation Belt Storm Probes (RBSP) mission will launch in late summer 2012 and begin its exploration of acceleration and dynamics of energetic particles in the inner magnetosphere. In this presentation, we discuss opportunities afforded by the RBSP Energetic Particle, Composition, and Thermal plasma (ECT) instrument suite to advance our understanding of acceleration processes in the radiation belts. The RBSP-ECT instrument suite comprehensively measures the electron and major ion populations of the inner magnetosphere, from the lowest thermal plasmas of the plasmasphere, to the hot plasma of the ring current, to the relativistic populations of the radiation belts. Collectively, the ECT measurements will reveal the complex cross-energy coupling of these colocated particle populations, which along with concurrent RBSP wave measurements, will permit various wave-particle acceleration mechanisms to be tested. We review the measurement capabilities of the RBSP-ECT instrument suite, and demonstrate several examples of how these measurements will be used to explore candidate acceleration mechanisms and dynamics of radiation belt particles.

Spence, Harlan; Reeves, Geoffrey

2012-07-01

392

Proc. of the 5 th Int. Conference on Digital Audio E#ects (DAFx02), Hamburg, Germany, September 2628, 2002 DOPPLER SIMULATION AND THE LESLIE  

E-print Network

, followed by a description of a Leslie simulator. 2. THE DOPPLER EFFECT In the real world, a Doppler shift­28, 2002 DOPPLER SIMULATION AND THE LESLIE Julius Smith, Stefania Serafin Center for Computer Research@uaudio.com dpberner@uaudio.com ABSTRACT An e#cient algorithm for simulating the Doppler e#ect us­ ing interpolating

Smith III, Julius Orion

393

Larger ClusterBoronxAE (B36Hx) Implant for USJ Applications  

NASA Astrophysics Data System (ADS)

The continued scaling of CMOS technology requires that junctions also continue to scale. At the 22 nm node, USJ depth is required to be around 10 nm. While achieving shallower junctions is relatively straightforward by lowering the implant energy, the need to create ever shallower junctions without increasing sheet resistance presents significant challenge. In order to maintain resistance, higher levels of activation are required as junction depth is scaled. In this work, two new technologies are investigated which together form a technology suite which will be shown capable of creating 10 nm p-type junctions with very high activation. The implant technology uses the dimer of octadecaborane as the implant species and the anneal technology is sub-microsecond excimer laser anneal.

Sekar, Karuppanan; Krull, Wade; Huet, Karim; Boniface, Celia; Venturini, Julien

2011-01-01

394

Accidental Implant Screwdriver Ingestion: A Rare Complication during Implant Placement  

PubMed Central

One of the complications during a routine dental implant placement is accidental ingestion of the implant instruments, which can happen when proper precautions are not taken. Appropriate radiographs should be taken to locate the correct position of foreign body; usually the foreign body passes asymptomatically from gastrointestinal tract but sometimes it may lead to intestinal obstruction, perforations and impactions. The aim of this article is to report accidental ingestion of 19 mm long screw driver by a senile patient. PMID:25628702

Jain, Anshul; Baliga, Shridhar D

2014-01-01

395

Immediate loading implants: a clinical report of 1301 implants.  

PubMed

The purpose of this study is to suggest 4 immediate load of implants techniques that are alternative and/or complementary to the traditional submersion technique. These techniques meet the criteria for implant immobilization during the entire period of osteointegration, and are based on the principles of splinting and load sharing. One hundred fifty-three maxillary and 309 mandibular arches were treated with 1301 implants. Only implants that satisfied the primary retention were immediately loaded with a provisional crown with wings (94), provisional plastic prosthesis (478), provisional plastic prosthesis with metal frame (293), and intraoral welding (436). Facies morphology, type of occlusion, size and function of the tongue, bone density, number, and length of implants appeared to have an influence on the results. Success rates achieved over 21 years are 99.3% with the intraoral welding machine, 98.3% with the provisional plastic prosthesis with metal frame, 97.9% with metal wings, and 88.02% with provisional plastic prosthesis. This last percentage is reflective of the years 1974 to 1984 when only blade-forms and root-forms with unscrewable abutments were available and a provisional plastic prosthesis was the only immobilization technique known. Guidelines are proposed for a treatment plan indicating when and why immediate loading implants can be suggested. PMID:12498468

Hruska, Arturo; Borelli, Paolo; Bordanaro, Assia Chiaramonte; Marzaduri, Eleonora; Hruska, Kurt-Lorenzo

2002-01-01

396

Fabrication of implantable microshunt using  

E-print Network

Fabrication of implantable microshunt using a novel channel sealing technique Alioune Diouf microelectromechanical systems MEMS fabrication processes. The key features of our mi- croshunt fabrication process fabrication process suitable for mass production. These features were realized using electroplating

397

ANTIARRHYTHMICS VERSUS IMPLANTABLE DEFIBRILLATORS (AVID)  

EPA Science Inventory

Evaluates whether use of an implantable cardiac defibrillator (ICD) results in reduction in total mortality, when compared with conventional pharmacological therapy, in patients resuscitated from sudden cardiac death who are otherwise at very high risk of mortality from arrhythmi...

398

Nanosurface – The Future of Implants  

PubMed Central

Nanotechnology is a relatively newer field of science that is finding enormous scope in the dental & medical science. Use of endosseous dental implant surfaces having nano-scale topography is fast becoming part of modern implantology. The purpose of this review is to discuss and understand the role of nanoscale surface modification of titanium materials for the purpose of improving various phases of implantology including osseointegration. Nanotechnology equips bioengineers with newer ways of interacting with relevant biological processes. On the other hand, the field of nanotechnology provides means of understanding and achieving cell specific functions. An understanding of the role of nano-topography leads to the significant osseointegration modulations by nanoscale modification of the implants surface. Use of nanotechnology to modify the topography of titanium endosseous implant can drastically improve cellular and tissue responses that may benefit osseointegration and dental implant procedures. PMID:24995264

Thakral, Rashmi; Sharma, Neeraj; Seth, Jyotsana; Vashisht, Pallavi

2014-01-01

399

Ceramic-Coated Implant Systems  

Microsoft Academic Search

Practitioners have used hydroxyapatite-coated (HA-coated) endosseous and subperiosteal implants in various forms for many years. These have included root forms in both screw and cylindrical shapes, blades, and subperiosteals. The clinical predictability remains controversial and subject to claims and counterclaims. The early days of dental implantology involving root-form implants recommended their placement in fully edentulous cases only, and anterior to

Roland M. Meffert

1999-01-01

400

Implantable Cardiac Rhythm Device Batteries  

Microsoft Academic Search

Batteries used for implantable cardiac rhythm devices are described herein. Fully implanted cardiac rhythm devices, pacemakers,\\u000a and defibrillators treat patients with various cardiomyopathies. Each of these devices contains a battery that supplies all\\u000a of the energy for device functions. As devices were developed with increased longevity, more features and reduced size, batteries\\u000a were designed with considerably greater energy and power.

Michael J. Root

2008-01-01

401

Why are mini-implants lost: The value of the implantation technique!  

PubMed Central

The use of mini-implants have made a major contribution to orthodontic treatment. Demand has aroused scientific curiosity about implant placement procedures and techniques. However, the reasons for instability have not yet been made totally clear. The aim of this article is to establish a relationship between implant placement technique and mini-implant success rates by means of examining the following hypotheses: 1) Sites of poor alveolar bone and little space between roots lead to inadequate implant placement; 2) Different sites require mini-implants of different sizes! Implant size should respect alveolar bone diameter; 3) Properly determining mini-implant placement site provides ease for implant placement and contributes to stability; 4) The more precise the lancing procedures, the better the implant placement technique; 5) Self-drilling does not mean higher pressures; 6) Knowing where implant placement should end decreases the risk of complications and mini-implant loss. PMID:25741821

Romano, Fabio Lourenço; Consolaro, Alberto

2015-01-01

402

Implantable Cardioverter Defibrillators. Prophylactic Use  

PubMed Central

Executive Summary Objective The use of implantable cardiac defibrillators (ICDs) to prevent sudden cardiac death (SCD) in patients resuscitated from cardiac arrest or documented dangerous ventricular arrhythmias (secondary prevention of SCD) is an insured service. In 2003 (before the establishment of the Ontario Health Technology Advisory Committee), the Medical Advisory Secretariat conducted a health technology policy assessment on the prophylactic use (primary prevention of SCD) of ICDs for patients at high risk of SCD. The Medical Advisory Secretariat concluded that ICDs are effective for the primary prevention of SCD. Moreover, it found that a more clearly defined target population at risk for SCD that would be likely to benefit from ICDs is needed, given that the number needed to treat (NNT) from recent studies is 13 to 18, and given that the per-unit cost of ICDs is $32,000, which means that the projected cost to Ontario is $770 million (Cdn). Accordingly, as part of an annual review and publication of more recent articles, the Medical Advisory Secretariat updated its health technology policy assessment of ICDs. Clinical Need Sudden cardiac death is caused by the sudden onset of fatal arrhythmias, or abnormal heart rhythms: ventricular tachycardia (VT), a rhythm abnormality in which the ventricles cause the heart to beat too fast, and ventricular fibrillation (VF), an abnormal, rapid and erratic heart rhythm. About 80% of fatal arrhythmias are associated with ischemic heart disease, which is caused by insufficient blood flow to the heart. Management of VT and VF with antiarrhythmic drugs is not very effective; for this reason, nonpharmacological treatments have been explored. One such treatment is the ICD. The Technology An ICD is a battery-powered device that, once implanted, monitors heart rhythm and can deliver an electric shock to restore normal rhythm when potentially fatal arrhythmias are detected. The use of ICDs to prevent SCD in patients resuscitated from cardiac arrest or documented dangerous ventricular arrhythmias (secondary prevention) is an insured service in Ontario. Primary prevention of SCD involves identification of and preventive therapy for patients who are at high risk for SCD. Most of the studies in the literature that have examined the prevention of fatal ventricular arrhythmias have focused on patients with ischemic heart disease, in particular, those with heart failure (HF), which has been shown to increase the risk of SCD. The risk of HF is determined by left ventricular ejection fraction (LVEF); most studies have focused on patients with an LVEF under 0.35 or 0.30. While most studies have found ICDs to reduce significantly the risk for SCD in patients with an LVEF less than 0.35, a more recent study (Sudden Cardiac Death in Heart Failure Trial [SCD-HeFT]) reported that patients with HF with nonischemic heart disease could also benefit from this technology. Based on the generalization of the SCD-HeFT study, the Centers for Medicare and Medicaid in the United States recently announced that it would allocate $10 billion (US) annually toward the primary prevention of SCD for patients with ischemic and nonischemic heart disease and an LVEF under 0.35. Review Strategy The aim of this literature review was to assess the effectiveness, safety, and cost effectiveness of ICDs for the primary prevention of SCD. The standard search strategy used by the Medical Advisory Secretariat was used. This included a search of all international health technology assessments as well as a search of the medical literature from January 2003–May 2005. A modification of the GRADE approach (1) was used to make judgments about the quality of evidence and strength of recommendations systematically and explicitly. GRADE provides a framework for structured reflection and can help to ensure that appropriate judgments are made. GRADE takes into account a study’s design, quality, consistency, and directness in judging the quality of evidence for each outcome. The balance between benefits and harms, quality of e

2005-01-01

403

Ion implanted dielectric elastomer circuits  

NASA Astrophysics Data System (ADS)

Starfish and octopuses control their infinite degree-of-freedom arms with panache—capabilities typical of nature where the distribution of reflex-like intelligence throughout soft muscular networks greatly outperforms anything hard, heavy, and man-made. Dielectric elastomer actuators show great promise for soft artificial muscle networks. One way to make them smart is with piezo-resistive Dielectric Elastomer Switches (DES) that can be combined with artificial muscles to create arbitrary digital logic circuits. Unfortunately there are currently no reliable materials or fabrication process. Thus devices typically fail within a few thousand cycles. As a first step in the search for better materials we present a preliminary exploration of piezo-resistors made with filtered cathodic vacuum arc metal ion implantation. DES were formed on polydimethylsiloxane silicone membranes out of ion implanted gold nano-clusters. We propose that there are four distinct regimes (high dose, above percolation, on percolation, low dose) in which gold ion implanted piezo-resistors can operate and present experimental results on implanted piezo-resistors switching high voltages as well as a simple artificial muscle inverter. While gold ion implanted DES are limited by high hysteresis and low sensitivity, they already show promise for a range of applications including hysteretic oscillators and soft generators. With improvements to implanter process control the promise of artificial muscle circuitry for soft smart actuator networks could become a reality.

O'Brien, Benjamin M.; Rosset, Samuel; Anderson, Iain A.; Shea, Herbert R.

2013-06-01

404

Body Implanted Medical Device Communications  

NASA Astrophysics Data System (ADS)

The medical care day by day and more and more is associated with and reliant upon concepts and advances of electronics and electromagnetics. Numerous medical devices are implanted in the body for medical use. Tissue implanted devices are of great interest for wireless medical applications due to the promising of different clinical usage to promote a patient independence. It can be used in hospitals, health care facilities and home to transmit patient measurement data, such as pulse and respiration rates to a nearby receiver, permitting greater patient mobility and increased comfort. As this service permits remote monitoring of several patients simultaneously it could also potentially decrease health care costs. Advancement in radio frequency communications and miniaturization of bioelectronics are supporting medical implant applications. A central component of wireless implanted device is an antenna and there are several issues to consider when designing an in-body antenna, including power consumption, size, frequency, biocompatibility and the unique RF transmission challenges posed by the human body. The radiation characteristics of such devices are important in terms of both safety and performance. The implanted antenna and human body as a medium for wireless communication are discussed over Medical Implant Communications Service (MICS) band in the frequency range of 402-405MHz.

Yazdandoost, Kamya Yekeh; Kohno, Ryuji

405

Auditory Midbrain Implant: A Review  

PubMed Central

The auditory midbrain implant (AMI) is a new hearing prosthesis designed for stimulation of the inferior colliculus in deaf patients who cannot sufficiently benefit from cochlear implants. The authors have begun clinical trials in which five patients have been implanted with a single shank AMI array (20 electrodes). The goal of this review is to summarize the development and research that has led to the translation of the AMI from a concept into the first patients. This study presents the rationale and design concept for the AMI as well a summary of the animal safety and feasibility studies that were required for clinical approval. The authors also present the initial surgical, psychophysical, and speech results from the first three implanted patients. Overall, the results have been encouraging in terms of the safety and functionality of the implant. All patients obtain improvements in hearing capabilities on a daily basis. However, performance varies dramatically across patients depending on the implant location within the midbrain with the best performer still not able to achieve open set speech perception without lip-reading cues. Stimulation of the auditory midbrain provides a wide range of level, spectral, and temporal cues, all of which are important for speech understanding, but they do not appear to sufficiently fuse together to enable open set speech perception with the currently used stimulation strategies. Finally, several issues and hypotheses for why current patients obtain limited speech perception along with several feasible solutions for improving AMI implementation are presented. PMID:19762428

Lim, Hubert H.; Lenarz, Minoo; Lenarz, Thomas

2009-01-01

406

Immediate implant placement and provisionalization using a customized anatomic temporary abutment (CATA) to achieve gingival margin stability.  

PubMed

As advances have progressed in implant dentistry, patient acceptance and long-term success rates have been on the rise. With technology ever improving, clinicians have taken treatment approaches that are aimed at a more immediate timetable as well as esthetics. The immediate implant placement and provisionalization protocol is now being applied to the anterior region. With esthetic concerns being at the forefront of implant dentistry, this case report highlights the importance of five key parameters that are related to the risk of recession following dental implant restoration in maxillary anterior sites. PMID:23991853

Ross, Scott B; Pette, Gregory A

2013-05-01

407

A living thick nanofibrous implant bifunctionalized with active growth factor and stem cells for bone regeneration  

PubMed Central

New-generation implants focus on robust, durable, and rapid tissue regeneration to shorten recovery times and decrease risks of postoperative complications for patients. Herein, we describe a new-generation thick nanofibrous implant functionalized with active containers of growth factors and stem cells for regenerative nanomedicine. A thick electrospun poly(?-caprolactone) nanofibrous implant (from 700 ?m to 1 cm thick) was functionalized with chitosan and bone morphogenetic protein BMP-7 as growth factor using layer-by-layer technology, producing fish scale-like chitosan/BMP-7 nanoreservoirs. This extracellular matrix-mimicking scaffold enabled in vitro colonization and bone regeneration by human primary osteoblasts, as shown by expression of osteocalcin, osteopontin, and bone sialoprotein (BSPII), 21 days after seeding. In vivo implantation in mouse calvaria defects showed significantly more newly mineralized extracellular matrix in the functionalized implant compared to a bare scaffold after 30 days’ implantation, as shown by histological scanning electron microscopy/energy dispersive X-ray microscopy study and calcein injection. We have as well bifunctionalized our BMP-7 therapeutic implant by adding human mesenchymal stem cells (hMSCs). The activity of this BMP-7-functionalized implant was again further enhanced by the addition of hMSCs to the implant (living materials), in vivo, as demonstrated by the analysis of new bone formation and calcification after 30 days’ implantation in mice with calvaria defects. Therefore, implants functionalized with BMP-7 nanocontainers associated with hMSCs can act as an accelerator of in vivo bone mineralization and regeneration. PMID:25709432

Eap, Sandy; Keller, Laetitia; Schiavi, Jessica; Huck, Olivier; Jacomine, Leandro; Fioretti, Florence; Gauthier, Christian; Sebastian, Victor; Schwinté, Pascale; Benkirane-Jessel, Nadia

2015-01-01

408

ects of sitting versus standing and scanner type on cashiers  

Microsoft Academic Search

In the retail supermarket industry where cashiers perform repetitive, light manual material-handling tasks when scanning and handling products, reports of musculoskeletal disorders and discomfort are high. Ergonomics tradeoŒ s exist between sitting and standing postures, which are further confounded by the checkstand design and point-of-sale technology, such as the scanner. A laboratory experiment study was conducted to understand the eŒ

K. R. LEHMAN; R. G. J. M EULENBROEK

409

[Biodeterioration and corrosion of metallic implants and prostheses].  

PubMed

The use of surgical implants and prosthetic devices to replace the original function of different components of the human biological system is a well established tradition in the history of medicine. Currently, one of the most prevalent points of view in dealing with this subject, is that of biocompatibility of materials of construction and methods of fabrication of these devices, in order to avoid negative impacts on the patient due to failure of implants through degradation mechanisms such as corrosion. This article presents a current general review of the relationship between biocompatibility and deterioration of metallic implants and prosthetic devices, emphasizing the specific forms that corrosion adopts in biological media. The historical perspective shows the consolidation of a tendency towards a more systematic study of these phenomena in recent years, as opposed to trial and error practices that used to be common before the third decade of this century. The understanding of interactions between implants and biological tissue, thus led to some of the most promising current techniques, such as the use of powder metallurgy components to optimize skeletal fixation of implants by means of interstitial bone growth into porous metallic surfaces. The review of metals and alloys currently used for the fabrication of implants shows the amplitude of available technological alternatives, as well as the multiple criteria required to make a good selection for each specific case. Applications and pros and cons of stainless steel, Cr, Ni, Co and Ti alloys, and tantalum are briefly discussed. The introduction to basic concepts of corrosion, serves as a basis for the description of the typical forms that these phenomena adopt in biological media, including pitting, crevice corrosion, fatigue-corrosion, stress corrosion, fretting corrosion, galvanic corrosion, and intergranular corrosion. This review shows that the study of interactions between biological media and metallic implants has become a well established and specific field of science. As a result of this conclusion, an interdisciplinary treatment of the subject of biodeterioration of metallic implants and prosthetic devices is proposed. In practical terms, this proposal can be understood as the integration of an expert in materials science and engineering to the medical team. Thus, quality and reliability of the implant, as well as maximization of its useful life, would be achieved through the implementation of technical specifications, accepted standards, and pertinent testing as recommended by the above mentioned expert, who will be the person of the team more able to grasp the novelties that the dynamic field of biomaterials constantly offers. PMID:8114635

López, G D

1993-01-01

410

Effects of oxygen ion implantation in spray-pyrolyzed ZnO thin films  

NASA Astrophysics Data System (ADS)

ZnO thin films, prepared using the chemical spray pyrolysis technique, were implanted using 100 keV O+ ions. Both pristine and ion-implanted samples were characterized using X-ray diffraction, optical absorption, electrical resistivity measurements, thermally stimulated current measurements and photoluminescence. Samples retained their crystallinity even after irradiation at a fluence of 1015 ions/cm2. However, at a still higher fluence of 2 × 1016 ions/cm2, the films became totally amorphous. The optical absorption edge remained unaffected by implantation and optical absorption spectra indicated two levels at 460 and 510 nm. These were attributed to defect levels corresponding to zinc vacancies (VZn) and oxygen antisites (OZn), respectively. Pristine samples had a broad photoluminescence emission centred at 517 nm, which was depleted on implantation. In the case of implanted samples, two additional emissions appeared at 425 and 590 nm. These levels were identified as due to zinc vacancies (VZn) and oxygen vacancies (VO), respectively. The electrical resistivity of implanted samples was much higher than that of pristine, while photosensitivity decreased to a very low value on implantation. This can be utilized in semiconductor device technology for interdevice isolation. Hall measurements showed a marked decrease in mobility due to ion implantation, while carrier concentration slightly increased.

Vijayakumar, K. P.; Ratheesh Kumar, P. M.; Sudha Kartha, C.; Wilson, K. C.; Singh, F.; Nair, K. G. M.; Kashiwaba, Y.

2006-04-01

411

Cyborg Technology  

NSDL National Science Digital Library

Discussions of cyborg technology tend to be relegated to science fiction literature and TV programs like Star Trek. This Topic in Depth looks into current issues and developments in the area of cyborg technology. The first website, from the UC Santa Barbara Department of English, (1) lists a variety of resources on cyborgs, from philosophical articles and literary criticism to current scientific practices. A related area of research is brain-computer interfacing (BCI), which is described on this website from the Helsinki Institute of Technology (2). Research on neural engineering, which combines work in electrical and computer engineering, tissue engineering, materials science, and nanotechnology, is also described on this website from USC (3). The Discovery School (4) suggests this lesson on technology for grades six through eight, in which students explore how the human body uses electric signals to send messages to and from the brain, and then how the nervous system uses those signals, with the option for additional discussions regarding the potential for cyborg technology. The next website from National Public Radio (5) provides a current look at applications of cyber technology, most of which are in the area of healthcare. For example, this program reports on how "scientists make it possible for quadriplegics to control a television, play simple computer games and check e-mail... by just thinking about it." Another interesting experiment--Project Cyborg--involves the neuro-surgical implantation of a device into the median nerves of this researchers' left arm and is described this website (6).

412

Effectiveness of implant therapy analyzed in a Swedish population: early and late implant loss.  

PubMed

Treatment outcomes in implant dentistry have been mainly assessed as implant survival rates in small, selected patient groups of specialist or university clinical settings. This study reports on loss of dental implants assessed in a large and randomly selected patient sample. The results were aimed at representing evaluation of effectiveness of implant dentistry. Using the national data register of the Swedish Social Insurance Agency, 4,716 patients were randomly selected. All had been provided with implant-supported restorative therapy in 2003. Patient files of 2,765 patients (11,311 implants) were collected from more than 800 clinicians. Information on patients, treatment procedures, and outcomes related to the implant-supported restorative therapy was extracted from the files. In total, 596 of the 2,765 subjects, provided with 2,367 implants, attended a clinical examination 9 y after therapy. Implant loss that occurred prior to connection of the supraconstruction was scored as an early implant loss, while later occurring loss was considered late implant loss. Early implant loss occurred in 4.4% of patients (1.4% of implants), while 4.2% of the patients who were examined 9 y after therapy presented with late implant loss (2.0% of implants). Overall, 7.6% of the patients had lost at least 1 implant. Multilevel analysis revealed higher odds ratios for early implant loss among smokers and patients with an initial diagnosis of periodontitis. Implants shorter than 10 mm and representing certain brands also showed higher odds ratios for early implant loss. Implant brand also influenced late implant loss. Implant loss is not an uncommon event, and patient and implant characteristics influence outcomes (ClinicalTrials.gov NCT01825772). PMID:25503901

Derks, J; Håkansson, J; Wennström, J L; Tomasi, C; Larsson, M; Berglundh, T

2015-03-01

413

'Fast-implantable' aortic valve implantation and concomitant mitral procedures.  

PubMed

Concomitant aortic and mitral valve replacement or concomitant aortic valve replacement and mitral repair can be a challenge for the cardiac surgeon: in particular, because of their structure and design, two bioprosthetic heart valves or an aortic valve prosthesis and a rigid mitral ring can interfere at the level of the mitroaortic junction. Therefore, when a mitral bioprosthesis or a rigid mitral ring is already in place and a surgical aortic valve replacement becomes necessary, or when older high-risk patients require concomitant mitral and aortic procedures, the new 'fast-implantable' aortic valve system (Intuity valve, Edwards Lifesciences, Irvine, CA, USA) can represent a smart alternative to standard aortic bioprosthesis. Unfortunately, this is still controversial (risk of interference). However, transcatheter aortic valve replacements have been performed in patients with previously implanted mitral valves or mitral rings. Interestingly, we learned that there is no interference (or not significant interference) among the standard valve and the stent valve. Consequently, we can assume that a fast-implantable valve can also be safely placed next to a biological mitral valve or next to a rigid mitral ring without risks of distortion, malpositioning, high gradient or paravalvular leak. This paper describes two cases: a concomitant Intuity aortic valve and bioprosthetic mitral valve implantation and a concomitant Intuity aortic valve and mitral ring implantation. PMID:25015540

Ferrari, Enrico; Siniscalchi, Giuseppe; Marinakis, Sotirios; Berdajs, Denis; von Segesser, Ludwig

2014-10-01

414

Design features of implants for direct skeletal attachment of limb prostheses  

PubMed Central

In direct skeletal attachment (DSA) of limb prostheses, a construct is implanted into an amputee’s residuum bone and protrudes out of the residuum’s skin. This technology represents an alternative to traditional suspension of prostheses via various socket systems, with clear indications when the sockets cannot be properly fitted. Contemporary DSA was invented in the 1990s, and several implant systems have been introduced since then. The current review is intended to compare the design features of implants for DSA whose use in humans or in animal studies has been reported in the literature. PMID:23554122

Pitkin, M.

2013-01-01

415

Activation of silicon ion-implanted gallium nitride by furnace annealing  

Microsoft Academic Search

Ion implantation into III–V nitride materials is animportant technology for high-power and high-temperature digital and monolithic\\u000a microwave integrated circuits. We report the results of the electrical, optical, and surface morphology of Si ion-implanted\\u000a GaN films using furnace annealing. We demonstrate high sheet-carrier densities for relatively low-dose (natoms=51014 cm?2) Si implants into AlN\\/GaN\\/sapphire heteroepitaxial films. The samples that were annealed at

R. D. Dupuis; C. J. Eiting; P. A. Grudowski; H. Hsia; Z. Tang; D. Becher; H. Kuo; G. E. Stillman; M. Feng

1999-01-01

416

[Risk factors and strategies of dental implants in the maxillary posterior without sufficient bone available].  

PubMed

There are two ways to place dental implants in the maxillary posterior without sufficient bone available, one is the maxillary sinus floor bone augmentation technique, the other is to evade maxillary sinus. The maxillary sinus floor bone augmentation technique may result in a series of complication, and reduce obedience of patients for implant surgery. According to principles of the best bone utilization, the evaded maxillary sinus implant technique is more simple, more economic, more predictable, and more shortage of time, compared with the maxillary sinus floor bone augmentation technique, and has certain technological advantages in some special cases. PMID:22389955

Huang, Jiansheng

2012-02-01

417

Behavior of AISI SAE 1020 Steel Implanted by Titanium and Exposed to Bacteria Sulphate Deoxidizer  

NASA Astrophysics Data System (ADS)

A hybrid technology to treat solid surfaces with the pulse high voltage and electric arc discharges of low pressure with a three-dimensional ion implantation technique (3DII) is applied. This technology is used to protect AISI SAE 1020 steel against a microbiological corrosion. The titanium ion implanted steel samples (coupons) are subjected to a medium of bacteria sulphate deoxidizer (BSD) which are very typical of the hydrocarbon industry and are potentially harmful for structures when are in contact with petroleum and some of its derivatives. The used technology aims to find an effective hybrid procedure to minimize the harmful effects of bacteria on AISI SAE 1020 steel. The hybrid technology efficiency of superficial titanium implantation is estimated through the measurements of the point corrosion characteristics obtained after testing both the treated and non-treated coupons. The three-dimensional surface structures of the samples are reconstructed with help of a confocal microscope.

Niño, Ely Dannier V.; Garnica, Hernán; Dugar-Zhabon, Veleriy; Castillo, Genis

2014-05-01

418

Biostability of an implantable glucose sensor chip  

NASA Astrophysics Data System (ADS)

Surface materials of an implantable microelectronic chip intended for medical applications were evaluated with respect to their long-term stability in bio-environments. The sensor chip shall apply in a glucose monitor by operating as a microviscosimeter according to the principle of affinity viscosimetry. A monolithic integration of a microelectromechanical system (MEMS) into the sensor chip was successfully performed in a combined 0.25 ?m CMOS/BiCMOS technology. In order to study material durability and biostability of the surfaces, sensor chips were exposed to various in vitro and in vivo tests. Corrosional damage of SiON, SiO2 and TiN surfaces was investigated by optical microscopy, ellipsometry and AFM. The results served for optimizing the Back-end-of-Line (BEoL) stack, from which the MEMS was prepared. Corrosion of metal lines could significantly be reduced by improving the topmost passivation layer. The experiments revealed no visible damage of the actuator or other functionally important MEMS elements. Sensor chips were also exposed to human body fluid for three month by implantation into the abdomen of a volunteer. Only small effects were observed for layer thickness and Ra roughness after explantation. In particular, TiN as used for the actuator beam showed no degradation by biocorrosion. The highest degradation rate of about 50 nm per month was revealed for the SiON passivation layer. These results suggest that the sensor chip may safely operate in subcutaneous tissue for a period of several months.

Fröhlich, M.; Birkholz, M.; Ehwald, K. E.; Kulse, P.; Fursenko, O.; Katzer, J.

2012-12-01

419

Characterizations of additive manufactured porous titanium implants.  

PubMed

This article describes physical, chemical, and mechanical characterizations of porous titanium implants made by an additive manufacturing method to gain insight into the correlation of process parameters and final physical properties of implants used in orthopedics. For the manufacturing chain, the powder metallurgy technology was combined with the additive manufacturing to fabricate the porous structure from the pure tanium powder. A 3D printing machine was employed in this study to produce porous bar samples. A number of physical parameters such as titanium powder size, polyvinyl alcohol (PVA) amount, sintering temperature and time were investigated to control the mechanical properties and porosity of the structures. The produced samples were characterized through porosity and shrinkage measurements, mechanical compression test and scanning electron microscopy (SEM). The results showed a level of porosity in the samples in the range of 31-43%, which is within the range of the porosity of the cancelluous bone and approaches the range of the porosity of the cortical bone. The results of the mechanical test showed that the compressive strength is in the wide range of 56-509 MPa implying the effect of the process parameters on the mechanical strengths. This technique of manufacturing of Ti porous structures demonstrated a low level of shrinkage with the shrinkage percentage ranging from 1.5 to 5%. PMID:22865677

Basalah, Ahmad; Shanjani, Yaser; Esmaeili, Shahrzad; Toyserkani, Ehsan

2012-10-01

420

Nanotechnologies for the formation of medical implants based on titanium alloys with bioactive coatings  

Microsoft Academic Search

The main approaches to the formation of modern functional materials for medical implants, including the principles of material\\u000a choice on the criteria of their biochemical and biomechanical compatibility and their technological effectiveness, are represented\\u000a in this review. Titanium alloys are considered the most prospective and extended materials for implants in traumatology, orthopedics,\\u000a and stomatology. The trend over the last decade

Yu. R. Kolobov

2009-01-01

421

State-of-the-art on cone beam CT imaging for preoperative planning of implant placement  

Microsoft Academic Search

Orofacial diagnostic imaging has grown dramatically in recent years. As the use of endosseous implants has revolutionized\\u000a oral rehabilitation, a specialized technique has become available for the preoperative planning of oral implant placement:\\u000a cone beam computed tomography (CT). This imaging technology provides 3D and cross-sectional views of the jaws. It is obvious\\u000a that this hardware is not in the same

Maria Eugenia Guerrero; Reinhilde Jacobs; Miet Loubele; Filip Schutyser; Paul Suetens; Daniel van Steenberghe

2006-01-01

422

Indium channel implant for improved short-channel behavior of submicrometer NMOSFETs  

Microsoft Academic Search

Indium has been used as an alternative channel implant in submicrometer-channel Si MOSFETs in order to obtain highly nonuniform channel doping. Superior device characteristics have been obtained down to 0.17-?m channel length. The device characteristics have been compared to those of uniform boron-implanted short-channel MOSFETs used in a 0.25-?m CMOS technology. Results indicate that NMOSFETs with nonuniform channel doping obtained

G. G. Shahidi; Bijan Davari; Thomas J. Bucelot; P. A. Ronsheim; P. J. Coane; S. Pollack; C. R. Blair; B. Clark; Howard H. Hansen

1993-01-01

423

FABRICATION OF METAL NANOPARTICLES IN SAPPHIRE BY LOW-ENERGY ION IMPLANTATION  

Microsoft Academic Search

The present review concentrates on the fabrication of metal nanoparticles in sapphire matrix by ion implantation and their modification by laser annealing. This approach is promising for the development of optical composite materials in the optoelectronics production technology. Composite layers were fabricated in sapphire by implantation of 40-keV Cu + ions at a dose of 1.0 . 10 17 ion\\/cm

A. L. Stepanov; I. B. Khaibullin

424

Fabrication of metal’s nanoparticles in silicon and sapphire by low energy ion implantation  

Microsoft Academic Search

This work devoted to the fabrication of metal nanoparticles in silicon and sapphire by ion implantation and their modification by laser annealing. This approach is promising for the development of optical composite materials in the optoelectronics production technology. Composite layers were fabricated in silicon by implantation of 40-keV Cu+ ions at a dose of 1017 ion\\/cm2 and an ion beam

D. Kh. Mirkarimov; T. D. Radjabov; A. I. Kamardin; Z. T. Khakimov

2007-01-01

425

Surface biotechnology for refining cochlear implants.  

PubMed

The advent of the cochlear implant is phenomenal because it is the first surgical prosthesis that is capable of restoring one of the senses. The subsequent rapid evolution of cochlear implants through increasing complexity and functionality has been synchronized with the recent advancements in biotechnology. Surface biotechnology has refined cochlear implants by directly influencing the implant–tissue interface. Emerging surface biotechnology strategies are exemplified by nanofibrous polymeric materials, topographical surface modification, conducting polymer coatings, and neurotrophin-eluting implants. Although these novel developments have received individual attention in the recent literature, the time has come to investigate their collective applications to cochlear implants to restore lost hearing. PMID:24404581

Tan, Fei; Walshe, Peter; Viani, Laura; Al-Rubeai, Mohamed

2013-12-01

426

Silicone breast prostheses implantation and explanation.  

PubMed

Breast implants have been used for augmentation and reconstruction for a 30-year period. Standard techniques have been used for the successful placement of mammary prostheses to enhance or replace breast tissue. All breast implants are surrounded by a capsule. The most common complication of breast implant surgery is hardening and contracture of the capsule. Explanation of implants is indicated for implant rupture, infection, extrusion, siliconoma, breast pain, painful capsular contracture, malposition, significant patient fear, and systemic symptoms thought secondary to implants. A number of alternatives are available for postexplant reconstruction, including myocutaneous flaps and free tissue transfers. PMID:7801141

Friedman, R J

1994-08-01

427

Implantable biomedical devices on bioresorbable substrates  

DOEpatents

Provided herein are implantable biomedical devices, methods of administering implantable biomedical devices, methods of making implantable biomedical devices, and methods of using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment. Each implantable biomedical device comprises a bioresorbable substrate, an electronic device having a plurality of inorganic semiconductor components supported by the bioresorbable substrate, and a barrier layer encapsulating at least a portion of the inorganic semiconductor components. Upon contact with a biological environment the bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between the implantable biomedical device and the target tissue in the biological environment.

Rogers, John A; Kim, Dae-Hyeong; Omenetto, Fiorenzo; Kaplan, David L; Litt, Brian; Viventi, Jonathan; Huang, Yonggang; Amsden, Jason

2014-03-04

428

A paradigm for the development and evaluation of novel implant topologies for bone fixation: in vivo evaluation.  

PubMed

While contemporary prosthetic devices restore some function to individuals who have lost a limb, there are efforts to develop bio-integrated prostheses to improve functionality. A critical step in advancing this technology will be to securely attach the device to remnant bone. To investigate mechanisms for establishing robust implant fixation in bone while undergoing loading, we previously used a topology optimization scheme to develop optimized orthopedic implants and then fabricated selected designs from titanium (Ti)-alloy with selective laser sintering (SLS) technology. In the present study, we examined how implant architecture and mechanical stimulation influence osseointegration within an in vivo environment. To do this, we evaluated three implant designs (two optimized and one non-optimized) using a unique in vivo model that applied cyclic, tension/compression loads to the implants. Eighteen (six per implant design) adult male canines had implants surgically placed in their proximal, tibial metaphyses. Experimental duration was 12 weeks; daily loading (peak load of ±22 N for 1000 cycles) was applied to one of each animal's bilateral implants for the latter six weeks. Following harvest, osseointegration was assessed by non-destructive mechanical testing, micro-computed tomography (microCT) and back-scatter scanning electron microscopy (SEM). Data revealed that implant loading enhanced osseointegration by significantly increasing construct stiffness, peri-implant trabecular morphology, and percentages of interface connectivity and bone ingrowth. While this experiment did not demonstrate a clear advantage associated with the optimized implant designs, osseointegration was found to be significantly influenced by aspects of implant architecture. PMID:22951278

Long, Jason P; Hollister, Scott J; Goldstein, Steven A

2012-10-11

429

Science Goals and Overview of the Radiation Belt Storm Probes (RBSP) Energetic Particle, Composition, and Thermal Plasma (ECT) Suite on NASA's Van Allen Probes Mission  

NASA Astrophysics Data System (ADS)

The Radiation Belt Storm Probes (RBSP)-Energetic Particle, Composition, and Thermal Plasma (ECT) suite contains an innovative complement of particle instruments to ensure the highest quality measurements ever made in the inner magnetosphere and radiation belts. The coordinated RBSP-ECT particle measurements, analyzed in combination with fields and waves observations and state-of-the-art theory and modeling, are necessary for understanding the acceleration, global distribution, and variability of radiation belt electrons and ions, key science objectives of NASA's Living With a Star program and the Van Allen Probes mission. The RBSP-ECT suite consists of three highly-coordinated instruments: the Magnetic Electron Ion Spectrometer (MagEIS), the Helium Oxygen Proton Electron (HOPE) sensor, and the Relativistic Electron Proton Telescope (REPT). Collectively they cover, continuously, the full electron and ion spectra from one eV to 10's of MeV with sufficient energy resolution, pitch angle coverage and resolution, and with composition measurements in the critical energy range up to 50 keV and also from a few to 50 MeV/nucleon. All three instruments are based on measurement techniques proven in the radiation belts. The instruments use those proven techniques along with innovative new designs, optimized for operation in the most extreme conditions in order to provide unambiguous separation of ions and electrons and clean energy responses even in the presence of extreme penetrating background environments. The design, fabrication and operation of ECT spaceflight instrumentation in the harsh radiation belt environment ensure that particle measurements have the fidelity needed for closure in answering key mission science questions. ECT instrument details are provided in companion papers in this same issue. In this paper, we describe the science objectives of the RBSP-ECT instrument suite on the Van Allen Probe spacecraft within the context of the overall mission objectives, indicate how the characteristics of the instruments satisfy the requirements to achieve these objectives, provide information about science data collection and dissemination, and conclude with a description of some early mission results.

Spence, H. E.; Reeves, G. D.; Baker, D. N.; Blake, J. B.; Bolton, M.; Bourdarie, S.; Chan, A. A.; Claudepierre, S. G.; Clemmons, J. H.; Cravens, J. P.; Elkington, S. R.; Fennell, J. F.; Friedel, R. H. W.; Funsten, H. O.; Goldstein, J.; Green, J. C.; Guthrie, A.; Henderson, M. G.; Horne, R. B.; Hudson, M. K.; Jahn, J.-M.; Jordanova, V. K.; Kanekal, S. G.; Klatt, B. W.; Larsen, B. A.; Li, X.; MacDonald, E. A.; Mann, I. R.; Niehof, J.; O'Brien, T. P.; Onsager, T. G.; Salvaggio, D.; Skoug, R. M.; Smith, S. S.; Suther, L. L.; Thomsen, M. F.; Thorne, R. M.

2013-11-01

430

Generator and Lead-Related Complications of Implantable Cardioverter Defibrillators  

PubMed Central

Background: Increase in the number of patients treated with Implantable Cardioverter Defibrillator (ICD) requests more attention regarding its complications. Objectives: This study aimed to assess the generator- and lead-related complications at implantation and during follow-up in the patients who were treated with ICD for primary and secondary prevention reasons. Methods: We retrospectively reviewed 255 consecutive patients who underwent transvenous ICD implantation for the first time in a 7-year period and were followed-up for 3 years at Tehran Heart Center. The personal and clinical data of the patients as well as specific data on the ICD implantation were retrieved. The frequency of each of the complications was reported and the study variables were compared between the patients with and without complications using Student’s t-test and chi-square test where appropriate. P values less than 0.05 were considered as statistically significant. Results: Out of a total of 525 implanted leads and 255 implanted devices in 255 patients (mean age = 62.57 ± 13.50 years; male = 196 [76.9%]), complications leading to generator or lead replacement occurred in 32 patients (12.5%). The results revealed no significant difference between the patients with and without complications regarding gender and age (P = 0.206 and P = 0.824, respectively). Also, no significant difference was found between the two groups concerning the ejection fraction (P = 0.271). Lead fracture was the most frequent lead-related complication and was observed in 17 patients (6.6%). Besides, it was mainly observed in the RV leads. Generator-related complications leading to generator replacement were observed in 2 patients (0.7%). Conclusions: Despite considerable improvements in the ICD technology, the rate of the ICD complications leading to device replacement and surgical revision, especially those related to the leads, is still clinically important. PMID:24936484

Yaminisharif, Ahmad; Soofizadeh, Nader; Shafiee, Akbar; Kazemisaeid, Ali; Jalali, Arash; Vasheghani-Farahani, Ali

2014-01-01

431

Critical appraisal of cardiac implantable electronic devices: complications and management  

PubMed Central

Population aging and broader indications for the implant of cardiac implantable electronic devices (CIEDs) are the main reasons for the continuous increase in the use of pacemakers (PMs), implantable cardioverter-defibrillators (ICDs) and devices for cardiac resynchronization therapy (CRT-P, CRT-D). The growing burden of comorbidities in CIED patients, the greater complexity of the devices, and the increased duration of procedures have led to an augmented risk of infections, which is out of proportion to the increase in implantation rate. CIED infections are an ominous condition, which often implies the necessity of hospitalization and carries an augmented risk of in-hospital death. Their clinical presentation may be either at pocket or at endocardial level, but they can also manifest themselves with lone bacteremia. The management of these infections requires the complete removal of the device and subsequent, specific, antibiotic therapy. CIED failures are monitored by competent public authorities, that require physicians to alert them to any failures, and that suggest the opportune strategies for their management. Although the replacement of all potentially affected devices is often suggested, common practice indicates the replacement of only a minority of devices, as close follow-up of the patients involved may be a safer strategy. Implantation of a PM or an ICD may cause problems in the patients’ psychosocial adaptation and quality of life, and may contribute to the development of affective disorders. Clinicians are usually unaware of the psychosocial impact of implanted PMs and ICDs. The main difference between PM and ICD patients is the latter’s dramatic experience of receiving a shock. Technological improvements and new clinical evidences may help reduce the total burden of shocks. A specific supporting team, providing psychosocial help, may contribute to improving patient quality of life. PMID:22915942

Padeletti, Luigi; Mascioli, Giosuè; Perini, Alessandro Paoletti; Grifoni, Gino; Perrotta, Laura; Marchese, Procolo; Bontempi, Luca; Curnis, Antonio

2011-01-01

432

Cochlear Implantation Updates: The Dallas Cochlear Implant Program  

PubMed Central

This report provides an overview of many research projects conducted by the Dallas Cochlear Implant Program, a joint enterprise between The University of Texas at Dallas, The University of Texas Southwestern Medical Center and Children’s Medical Center. The studies extend our knowledge of factors influencing communication outcomes in users of cochlear implants. Multiple designs and statistical techniques are used in the studies described including both cross sectional and longitudinal analyses. Sample sizes vary across the studies and many of the samples represent large populations of children from North America. Multiple statistical techniques are used by the team to analyze outcomes. The team has provided critical information regarding electrode placement, signal processing, and communication outcomes in users of cochlear implants. PMID:22668764

Tobey, Emily A.; Britt, Lana; Geers, Ann; Loizou, Philip; Loy, Betty; Roland, Peter; Warner-Czyz, Andrea; Wright, Charles G.

2013-01-01

433

Multicomponent Implant Releasing Dexamethasone  

NASA Astrophysics Data System (ADS)

Several inflammatory conditions are usually treated with corticosteroids. There are various problems like side effects with traditional applications of steroids, e.g. topical, or systemic routes. Local drug delivery systems have been studied and developed to gain more efficient administration with fewer side effects. Earlier, we reported on developing Dexamethasone (DX) releasing biodegradable fibers. However, their drug release properties were not satisfactory in terms of onset of drug release. Thus, we assessed the development of multicomponent (MC) implant to enhance earlier drug release from such biodegradable fibers. Poly (lactide-co-glycolide) (PLGA) and 2 wt-% and 8 wt-% DX were compounded and extruded with twin-screw extruder to form of fibers. Some of the fibers were sterilized to obtain a change in drug release properties. Four different fiber classes were studied: 2 wt-%, 8 wt-%, sterilized 2 wt-%, and sterilized 8 wt-%. 3×4 different DX-releasing fibers were then heat-pressed to form one multicomponent rod. Half of the rods where sterilized. Drug release was measured from initial fibers and multicomponent rods using a UV/VIS spectrometer. Shear strength and changes in viscosity were also measured. Drug release studies showed that drug release commenced earlier from multicomponent rods than from component fibers. Drug release from multicomponent rods lasted from day 30 to day 70. The release period of sterilized rods extended from day 23 to day 57. When compared to the original component fibers, the drug release from MC rods commenced earlier. The initial shear strength of MC rods was 135 MPa and decreased to 105 MPa during four weeks of immersion in phosphate buffer solution. Accordingly, heat pressing has a positive effect on drug release. After four weeks in hydrolysis, no disintegration was observed.

Nikkola, L.; Vapalahti, K.; Ashammakhi, N.

2008-02-01

434

Implant Systems -Electrode  

E-print Network

. Robustness ­ our fabrication technology allows for long, continuous structures to be formed, incorporating Laboratory Tower A, 7 London Circuit Canberra City ACT 2601 Tel: +61 2 6267 6200 VRL - Victoria Research Innovation House First Avenue Mawson Lakes SA 5095 Tel: +61 8 8302 3928 NICTA is Australia's Information

Heiser, Gernot

435

Ion implanted step recovery diodes - influence of material parameter variations  

E-print Network

investigated. . . 2 3 5 7 11 HYBRID SRD STRUCTURES. 14 First Generation Devices. Device processing. Experimental results. Difficulties and Technology Development. . Starting material. Boron implantation Photolithography and mesa etching..., 4, and 2 mil dots as appear after chromium and gold etches but before mesa etching, 17 175X magnified view of gold-chromium dot, diameter of dot is 12 mils, shadow due to mesa. 19 9. Step recovery diode cross section. 20 10 I-V characteristics...

Mosman, Thomas Michael

1974-01-01

436

21 CFR 872.3980 - Endosseous dental implant accessories.  

Code of Federal Regulations, 2014 CFR

... Endosseous dental implant accessories. 872...DEVICES DENTAL DEVICES Prosthetic Devices § 872.3980 Endosseous dental implant accessories. (a... Endosseous dental implant accessories are manually...of endosseous dental implants and abutments,...

2014-04-01

437

21 CFR 872.3980 - Endosseous dental implant accessories.  

Code of Federal Regulations, 2012 CFR

... Endosseous dental implant accessories. 872...DEVICES DENTAL DEVICES Prosthetic Devices § 872.3980 Endosseous dental implant accessories. (a... Endosseous dental implant accessories are manually...of endosseous dental implants and abutments,...

2012-04-01

438

21 CFR 872.3980 - Endosseous dental implant accessories.  

Code of Federal Regulations, 2010 CFR

... Endosseous dental implant accessories. 872...DEVICES DENTAL DEVICES Prosthetic Devices § 872.3980 Endosseous dental implant accessories. (a... Endosseous dental implant accessories are manually...of endosseous dental implants and abutments,...

2010-04-01

439

Conducting polymers by ion implantation  

NASA Astrophysics Data System (ADS)

An electrically conductive surface can be created by using the ion implantation process on nonconducting polymeric sheet. The resulting conductivity was measured and correlated to ion beam parameters, such as ion species, dose, and energy. Additionally, a reaction model, in both physical and chemical terms, was proposed, which can assist in understanding of the underlying mechanisms during the ion implantation of polymers. The surface microscopic structure of the ion-implanted polymer specimens was evaluated by X-ray photoelectron spectroscopy (XPS), electron spin resonance (ESR), Rutherford backscattering spectroscopy (RBS), and infrared spectroscopy (IR). The experimental results indicated that the ion bombardment process leads to a carbon-enriched material in a manner akin to the carbonization of organic films observed upon pyrolytic processing.

Loh, I. H.; Oliver, R. W.; Sioshansi, P.

1988-09-01

440

Developmental Neuroplasticity After Cochlear Implantation  

PubMed Central

Cortical development is dependent on stimulus-driven learning. The absence of sensory input from birth, as occurs in congenital deafness, affects normal growth and connectivity needed to form a functional sensory system—resulting in deficits in oral language learning. Cochlear implants bypass cochlear damage by directly stimulating the auditory nerve and brain, making it possible to avoid many of the deleterious effects of sensory deprivation. Congenitally deaf animals and children who receive implants provide a platform to examine the characteristics of cortical plasticity in the auditory system. In this review, we discuss the existence of, time limits for, and mechanistic constraints on sensitive periods for cochlear implantation and describe the effects of multimodal and cognitive re-organization that results from long-term auditory deprivation. PMID:22104561

Kral, Andrej; Sharma, Anu

2013-01-01

441

21 CFR 522.1350 - Melatonin implant.  

Code of Federal Regulations, 2014 CFR

...INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.1350 Melatonin implant. (a) Specifications. The drug is a silicone rubber elastomer implant containing 2.7 milligrams of melatonin. (b) Sponsor. See No. 053923 in §...

2014-04-01

442

21 CFR 522.1350 - Melatonin implant.  

Code of Federal Regulations, 2012 CFR

...INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.1350 Melatonin implant. (a) Specifications . The drug is a silicone rubber elastomer implant containing 2.7 milligrams of melatonin. (b) Sponsor . See No. 053923 in §...

2012-04-01

443

21 CFR 522.1350 - Melatonin implant.  

Code of Federal Regulations, 2013 CFR

...INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.1350 Melatonin implant. (a) Specifications . The drug is a silicone rubber elastomer implant containing 2.7 milligrams of melatonin. (b) Sponsor . See No. 053923 in §...

2013-04-01

444

21 CFR 522.1350 - Melatonin implant.  

Code of Federal Regulations, 2011 CFR

...INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.1350 Melatonin implant. (a) Specifications . The drug is a silicone rubber elastomer implant containing 2.7 milligrams of melatonin. (b) Sponsor . See No. 053923 in §...

2011-04-01

445

21 CFR 522.1350 - Melatonin implant.  

Code of Federal Regulations, 2010 CFR

...INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.1350 Melatonin implant. (a) Specifications . The drug is a silicone rubber elastomer implant containing 2.7 milligrams of melatonin. (b) Sponsor . See No. 053923 in §...

2010-04-01

446

Dental implants. 7. Basic restorative techniques.  

PubMed

Some restorative techniques for implant supported restorations will be familiar to dentists used to providing conventional crown and bridgework. The differences and principles involved when using implants are identified. PMID:10729981

Howe, L; Barrett, V; Palmer, P

1999-11-13

447

21 CFR 878.4300 - Implantable clip.  

Code of Federal Regulations, 2010 CFR

...FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4300 Implantable clip. (a) Identification. An implantable clip...

2010-04-01

448

21 CFR 878.4750 - Implantable staple.  

Code of Federal Regulations, 2010 CFR

...FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4750 Implantable staple. (a) Identification. An implantable...

2010-04-01

449

Physiological and molecular determinants of embryo implantation  

PubMed Central

Embryo implantation involves the intimate interaction between an implantation-competent blastocyst and a receptive uterus, which occurs in a limited time period known as the window of implantation. Emerging evidence shows that defects originating during embryo implantation induce ripple effects with adverse consequences on later gestation events, highlighting the significance of this event for pregnancy success. Although a multitude of cellular events and molecular pathways involved in embryo-uterine crosstalk during implantation have been identified through gene expression studies and genetically engineered mouse models, a comprehensive understanding of the nature of embryo implantation is still missing. This review focuses on recent progress with particular attention to physiological and molecular determinants of blastocyst activation, uterine receptivity, blastocyst attachment and uterine decidualization. A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women. PMID:23290997

Zhang, Shuang; Lin, Haiyan; Kong, Shuangbo; Wang, Shumin; Wang, Hongmei; Wang, Haibin; Armant, D. Randall

2014-01-01

450

A low-power cochlear implant system  

E-print Network

Cochlear implants, or bionic ears, restore hearing to the profoundly deaf by bypassing missing inner-ear hair cells in the cochlea and electrically stimulating the auditory nerve. For miniaturized cochlear implants, including ...

Baker, Michael W. (Michael Warren), 1977-

2007-01-01

451

21 CFR 878.4300 - Implantable clip.  

Code of Federal Regulations, 2013 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4300 Implantable clip. (a) Identification. An implantable clip is a...

2013-04-01

452

21 CFR 878.4750 - Implantable staple.  

Code of Federal Regulations, 2014 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4750 Implantable staple. (a) Identification. An implantable staple is a...

2014-04-01

453

21 CFR 878.4300 - Implantable clip.  

Code of Federal Regulations, 2014 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4300 Implantable clip. (a) Identification. An implantable clip is a...

2014-04-01

454

21 CFR 878.4300 - Implantable clip.  

Code of Federal Regulations, 2011 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4300 Implantable clip. (a) Identification. An implantable clip is a...

2011-04-01

455

21 CFR 878.4750 - Implantable staple.  

Code of Federal Regulations, 2012 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4750 Implantable staple. (a) Identification. An implantable staple is a...

2012-04-01

456

21 CFR 878.4300 - Implantable clip.  

Code of Federal Regulations, 2012 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4300 Implantable clip. (a) Identification. An implantable clip is a...

2012-04-01

457

21 CFR 878.4750 - Implantable staple.  

Code of Federal Regulations, 2011 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4750 Implantable staple. (a) Identification. An implantable staple is a...

2011-04-01

458

21 CFR 878.4750 - Implantable staple.  

Code of Federal Regulations, 2013 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4750 Implantable staple. (a) Identification. An implantable staple is a...

2013-04-01

459

Radial 32P ion implantation using a coaxial plasma reactor: Activity imaging and numerical integration  

NASA Astrophysics Data System (ADS)

Beta-emitting biomedical implants are currently employed in angioplasty, in the treatment of certain types of cancers, and in the embolization of aneurysms with platinum coils. Radioisotopes such as 32P can be implanted using plasma-based ion implantation (PBII). In this article, we describe a reactor that was developed to implant radioisotopes into cylindrical metallic objects. The plasma first ionizes radioisotopes sputtered from a target, and then acts as the source of particles to be implanted into the biased biomedical device. The plasma therefore plays a major role in the ionization/implantation process. Following a sequence of implantation tests, the liners protecting the interior walls of the reactor were changed and the radioactivity on them measured. This study demonstrates that the radioactive deposits on these protective liners, adequately imaged by radiography, can indicate the distribution of the radioisotopes that are not implanted. The resulting maps give unique information about the activity distribution, which is influenced by the sputtering of the 32P-containing fragments, their ionization in the plasma, and also by the subsequent ion transport mechanisms. Such information can be interpreted and used to significantly improve the efficiency of the implantation procedure. Using a surface barrier detector, a comparative study established a relationship between the gray scale of radiographs of the liners, and activity measurements. An integration process allows the quantification of the activities on the walls and components of the reactor. Finally, the resulting integral of the 32P activity is correlated to the sum of the radioactivity amounts that were sputtered from radioactive targets inside the implanter before the dismantling procedure. This balance addresses the issue of security regarding PBII technology and confirms the confinement of the radioactivity inside the chamber.

Fortin, M. A.; Dufresne, V.; Paynter, R.; Sarkissian, A.; Stansfield, B.

2004-12-01

460

Radial {sup 32}P ion implantation using a coaxial plasma reactor: Activity imaging and numerical integration  

SciTech Connect

Beta-emitting biomedical implants are currently employed in angioplasty, in the treatment of certain types of cancers, and in the embolization of aneurysms with platinum coils. Radioisotopes such as {sup 32}P can be implanted using plasma-based ion implantation (PBII). In this article, we describe a reactor that was developed to implant radioisotopes into cylindrical metallic objects. The plasma first ionizes radioisotopes sputtered from a target, and then acts as the source of particles to be implanted into the biased biomedical device. The plasma therefore plays a major role in the ionization/implantation process. Following a sequence of implantation tests, the liners protecting the interior walls of the reactor were changed and the radioactivity on them measured. This study demonstrates that the radioactive deposits on these protective liners, adequately imaged by radiography, can indicate the distribution of the radioisotopes that are not implanted. The resulting maps give unique information about the activity distribution, which is influenced by the sputtering of the {sup 32}P-containing fragments, their ionization in the plasma, and also by the subsequent ion transport mechanisms. Such information can be interpreted and used to significantly improve the efficiency of the implantation procedure. Using a surface barrier detector, a comparative study established a relationship between the gray scale of radiographs of the liners, and activity measurements. An integration process allows the quantification of the activities on the walls and components of the reactor. Finally, the resulting integral of the {sup 32}P activity is correlated to the sum of the radioactivity amounts that were sputtered from radioactive targets inside the implanter before the dismantling procedure. This balance addresses the issue of security regarding PBII technology and confirms the confinement of the radioactivity inside the chamber.

Fortin, M.A.; Dufresne, V.; Paynter, R.; Sarkissian, A.; Stansfield, B. [INRS-EMT, 1650 boulevard Lionel Boulet, Varennes, Quebec J3X 1S2 (Canada); Plasmionique Inc., 1650 boulevard Lionel Boulet, Varennes, Quebec J3X 1S2 (Canada); INRS-EMT, 1650 boulevard Lionel Boulet, Varennes, Quebec J3X 1S2 (Canada)

2004-12-01

461

Neurophysiologic Basis for Cochlear and Auditory Brainstem Implants  

E-print Network

Neurophysiologic Basis for Cochlear and Auditory Brainstem Implants Aage R. Møller Callier Center for cochlear and brainstem implants is discussed. It is concluded that the success of cochlear implants may: cochlear implants, brainstem implants, auditory physiology. Cochlear implants were pioneered by Michelson

O'Toole, Alice J.

462

JAY HAN-CHIEH CHANG Postdoctoral Scholar in Electrical Engineering, California Institute of Technology  

E-print Network

Implant; Chip Integration; Packaging M.S. in Electrical Engineering , National Taiwan University, Taiwan directly Integrate chips, coils and discrete components on parylene-based implant device (flexible PCB implant and biomedical microdevices 3 years' experience in display design technology, focusing on organic

Tai, Yu-Chong

463

Mutation breeding by ion implantation  

NASA Astrophysics Data System (ADS)

Ion implantation as a new mutagenic method has been used in the rice breeding program since 1986, and for mutation breeding of other crops later. It has been shown, in principle and in practice, that this method has many outstanding advantages: lower damage rate; higher mutation rate and wider mutational spectrum. Many new lines of rice with higher yield rate; broader disease resistance; shorter growing period but higher quality have been bred from ion beam induced mutants. Some of these lines have been utilized for the intersubspecies hybridization. Several new lines of cotton, wheat and other crops are now in breeding. Some biophysical effects of ion implantation for crop seeds have been studied.

Yu, Zengliang; Deng, Jianguo; He, Jianjun; Huo, Yuping; Wu, Yuejin; Wang, Xuedong; Lui, Guifu

1991-07-01

464

The cochlear implant; basic principles.  

PubMed

In recent years the cochlear implant has been a subject of much discussion and controversy. The clinician has often been confused by the conflicting reports of success and failure. In this paper the development of the cochlear implant is reviewed and its present status summarized. It is hoped that the clinician may thereby gain an understanding of this device so that he can better evaluate its present and future status. Selection of Patients for Cochlear Implantation. The cochlear implant will benefit only those patients with hair cell loss who have remaining viable auditory neurons. In order to determine whether viable neurons remain, an electric current is passed through a small needle which is place into the promontory through the tympanic membrane. If patients experience an auditory sensation as a result of this electrical stimulation, it is felt that they are suitable candidates for a cochlear implant. Feasibility of Long-Term VIIIth Nerve Stimulation. Many questions have been raised regarding the feasibility of long-term stimulation of the auditory nerve. The first question raised was whether the auditory nerve would survive severe hair cell degeneration. Studies have shown that in most cases at least a few auditory neurons remain. The next question was whether the cochlear implant itself would destroy the remaining auditory neurons. Preliminary studies have shown that the nerve will survive the placement of electrodes both into the modiolus and the scala tympani. Several electrode materials and insulation have been found to be well tolerated, and there has been minimal damage from thermal or electrolytic processes; therefore, it appears feasible to stimulate the auditory nerve over a long period. Information Transfer by Electrical Stimulation. Single-channel stimulation produces only periodicity pitch, and information transfer is insufficient for speech discrimination. Experience to date indicates that it will be possible to produce both place and volley pitch by electrical stimulation with multiple electrodes in the scala tympani. These findings give promise for the feasibility of producing a device which will transfer sufficient information to produce speech discrimination. Present Status of the Cochlear Implant. To the present time 15 patients have been implanted with a unipolar electrode under the direction of the Ear Research Institute. These patients have all benefited from their devices. They are able to perceive background sounds and receive a cadence or rhythm to speech which makes the device helpful in lipreading. None of the patients have developed significant speech discrimination. PMID:1256212

Brackmann, D E

1976-03-01

465

Surface studies on titanium IMZ implants.  

PubMed

The aim of this study was to investigate the surface feature of the IMZ implant. Eight non-implanted new samples and four implanted samples removed one year after insertion were prepared. The 8 non-implanted samples were divided into two groups. The first group was sterilized and the second group was manipulated by bare hands. The implanted samples underwent a careful procedure to recover the metal surface. Then, both the non-implanted new samples and implanted samples were subjected to X-ray electron spectroscopy (XPS) and Rutherford back-scattering spectroscopy (KBS) analyses. Subsequently, all the samples were subjected to scanning electron microscopic (SEM) examination, and surface roughness and profilometric measurements. The SEM photomicrograph showed a rough surface composed of fused granular metal separated by gaps. Sometimes the presence of isolated well-shaped granules of 0.8-1.8 microns in diameter was observed. This structure was related to the manufacturing process of the IMZ implant. The implanted surfaces showed no intergranular gaps and appeared less rough (average roughness: Ra = 1.91 +/- 0.1 microns) compared with the new non-implanted surfaces (Ra = 4.93 +/- 0.3). XPS analysis at a maximum resolution depth of 1.5 nm revealed TiO2, C, O compounds on sterilized non-implanted surfaces. The hand-handled non-implanted surfaces on the contrary did not show TiO2 due to contamination. The elements Ca, C, O and N were found on the one-year implanted IMZ surfaces; TiO2, however, was absent. RBS analysis at a maximum resolution depth of 1000 nm, indicated a decrease of the total thickness of TiO2 after one year of IMZ implantation. The TiO2 thickness was 0.5-0.7 microns for the non-implanted new IMZ surfaces and 0.03-0.2 microns for implanted IMZ surfaces. PMID:1939048

Kuliralo, M; Pireaux, J J; Caudano, R; Dourov, E N

1991-09-01

466

Ion implantation of superhard ceramic cutting tools  

Microsoft Academic Search

Despite numerous reports of tool life increase by ion implantation in machining operations, ion implantation applications\\u000a of cutting tools remain limited, especially for ceramic tools. Mechanisms of tool-life improvement by implantation are not\\u000a clearly established due to complexity of both implantation and tool-wear processes. In an attempt to improve performance of\\u000a cubic boron nitride (CBN) tools for hard machining by

Y. Kevin Chou; Jie Liu

2004-01-01

467

Domination game: e#ect of edge and vertexremoval Bostjan Bresar a Paul Dorbec b Sandi Klavzar c,a Gasper Kosmrlj c  

E-print Network

Domination game: e#ect of edge­ and vertex­removal BoŸstjan BreŸsar a Paul Dorbec b Sandi Klav sandi.klavzar@fmf.uni­lj.si gasper.kosmrlj@student.fmf.uni­lj.si Abstract The domination game is played is that the game is finished as soon as possible, while Staller wants the game to last as long as possi